Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC30A2	7780	broad.mit.edu	37	1	26371545	26371545	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr1:26371545G>A	uc001blh.1	-	2	431	c.214C>T	c.(214-216)CGC>TGC	p.R72C	SLC30A2_uc001blg.1_Missense_Mutation_p.R72C	NM_032513	NP_115902	Q9BRI3	ZNT2_HUMAN	solute carrier family 30, member 2 isoform 2	72	Cytoplasmic (Potential).				positive regulation of sequestering of zinc ion|zinc ion transport	integral to membrane|late endosome|lysosomal membrane	cation transmembrane transporter activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.09e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00614)|READ - Rectum adenocarcinoma(331;0.0649)		TACAGCTGGCGCTGGGCCTTC	0.532000													91	115					0	0	0.048971	0	0
NOTCH2	4853	broad.mit.edu	37	1	120510154	120510154	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr1:120510154C>T	uc001eik.2	-	8	1611	c.1355G>A	c.(1354-1356)CGT>CAT	p.R452H	NOTCH2_uc001eil.2_Missense_Mutation_p.R452H|NOTCH2_uc001eim.3_Missense_Mutation_p.R369H	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	452	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATCTCACAACGAGGTCCTGC	0.498000			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				10	111					0	0	0.069234	0	0
XCL1	6375	broad.mit.edu	37	1	168550354	168550354	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr1:168550354G>A	uc001gfo.1	+	3	261	c.241G>A	c.(241-243)GTC>ATC	p.V81I		NM_002995	NP_002986	P47992	XCL1_HUMAN	chemokine (C motif) ligand 1	81					CD4-positive, alpha-beta T cell proliferation|CD8-positive, alpha-beta T cell proliferation|cell-cell signaling|cellular response to interleukin-4|cellular response to transforming growth factor beta stimulus|immunoglobulin production in mucosal tissue|lymphocyte chemotaxis|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell cytokine production|negative regulation of T-helper 1 cell activation|negative regulation of transcription, DNA-dependent|neutrophil chemotaxis|positive regulation of activated T cell proliferation|positive regulation of B cell chemotaxis|positive regulation of granzyme A production|positive regulation of granzyme B production|positive regulation of interleukin-10 production|positive regulation of natural killer cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell chemotaxis|positive regulation of T cell cytokine production|positive regulation of T cell mediated cytotoxicity|positive regulation of thymocyte migration|positive regulation of transforming growth factor-beta production|regulation of inflammatory response|release of sequestered calcium ion into cytosol|response to virus|T-helper 1 cell cytokine production|T-helper 2 cell cytokine production	extracellular space	chemokine activity|protein homodimerization activity				0	all_hematologic(923;0.208)					GAGAGACGTGGTCAGGAGCAT	0.483000													21	40					0	0	0.030593	0	0
MIA3	375056	broad.mit.edu	37	1	222828024	222828024	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr1:222828024G>A	uc001hnl.2	+	18	4505	c.4496G>A	c.(4495-4497)CGC>CAC	p.R1499H	MIA3_uc001hnm.2_Missense_Mutation_p.R377H	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1499	Cytoplasmic (Potential).|Potential.				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		GAAGATGACCGCAACTCACTA	0.448000													3	72					0	0	0.004672	0	0
SLIT1	6585	broad.mit.edu	37	10	98819232	98819232	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr10:98819232C>T	uc001kmw.2	-	11	1322	c.1070G>A	c.(1069-1071)CGC>CAC	p.R357H	SLIT1_uc009xvh.1_Missense_Mutation_p.R367H	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	357					axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GTTCAGGGAGCGGAGGCCCTG	0.622000													19	53					0	0	0.018920	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64601218	64601218	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr11:64601218G>A	uc001obs.3	-	22	2557	c.2557C>T	c.(2557-2559)CGC>TGC	p.R853C		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	853					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						ACCCCCATGCGCAGGCTGCGT	0.687000													3	40					0	0	0.009096	0	0
ABCC11	85320	broad.mit.edu	37	16	48211013	48211013	+	Silent	SNP	C	T	T			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr16:48211013C>T	uc002eff.1	-	24	3710	c.3360G>A	c.(3358-3360)TCG>TCA	p.S1120S	ABCC11_uc002efg.1_Silent_p.S1120S|ABCC11_uc002efh.1_Silent_p.S1120S|ABCC11_uc010cbg.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	1120	Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				AAGGAGCTTCCGAGACACACA	0.483000									Cerumen_Type				14	27					0	0	0.033300	0	0
TP53	7157	broad.mit.edu	37	17	7577574	7577574	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr17:7577574T>C	uc002gim.2	-	7	901	c.707A>G	c.(706-708)TAC>TGC	p.Y236C	TP53_uc002gig.1_Missense_Mutation_p.Y236C|TP53_uc002gih.2_Missense_Mutation_p.Y236C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y104C|TP53_uc010cng.1_Missense_Mutation_p.Y104C|TP53_uc002gii.1_Missense_Mutation_p.Y104C|TP53_uc010cnh.1_Missense_Mutation_p.Y236C|TP53_uc010cni.1_Missense_Mutation_p.Y236C|TP53_uc002gij.2_Missense_Mutation_p.Y236C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y143C|TP53_uc002gio.2_Missense_Mutation_p.Y104C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	236	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> S (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y236C(46)|p.Y236N(12)|p.Y236*(9)|p.Y236H(9)|p.0?(7)|p.Y236D(6)|p.Y236del(4)|p.Y236S(3)|p.Y236Y(2)|p.Y236fs*4(2)|p.Y236_M237delYM(1)|p.I232_Y236delIHYNY(1)|p.Y236fs*5(1)|p.H233fs*6(1)|p.Y236_M237insXX(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.N235_Y236delNY(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTACACATGTAGTTGTAGTG	0.572000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			66	17					0	0	0.048971	0	0
EVI2B	2124	broad.mit.edu	37	17	29631309	29631309	+	Missense_Mutation	SNP	A	T	T			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr17:29631309A>T	uc002hgk.2	-	2	1474	c.1319T>A	c.(1318-1320)CTG>CAG	p.L440Q	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.L455Q	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	440	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		TGGAGGTGGCAGGGATTCATT	0.363000													3	64					0	0	0.009096	0	0
RNF43	54894	broad.mit.edu	37	17	56435582	56435582	+	Nonsense_Mutation	SNP	G	A	A			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr17:56435582G>A	uc002iwf.2	-	8	3511	c.1555C>T	c.(1555-1557)CGA>TGA	p.R519*	RNF43_uc010wnv.1_Nonsense_Mutation_p.R478*|RNF43_uc002iwh.3_Nonsense_Mutation_p.R519*|RNF43_uc002iwg.3_Nonsense_Mutation_p.R519*|RNF43_uc010dcw.2_Nonsense_Mutation_p.R392*	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	519	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ATGTCCACTCGCTGGGGATCC	0.592000													62	72					0	0	0.048971	0	0
MARCH10	162333	broad.mit.edu	37	17	60879010	60879010	+	Silent	SNP	A	G	G			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr17:60879010A>G	uc010ddr.2	-	2	325	c.87T>C	c.(85-87)TAT>TAC	p.Y29Y	MARCH10_uc002jag.3_Silent_p.Y29Y|MARCH10_uc010dds.2_Silent_p.Y29Y|MARCH10_uc002jah.2_Silent_p.Y29Y	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	29							ligase activity|zinc ion binding				0						CAATTACCTGATACTCAGAGT	0.428000													19	137					0	0	0.069288	0	0
MOBKL2A	126308	broad.mit.edu	37	19	2076843	2076843	+	Silent	SNP	G	A	A			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr19:2076843G>A	uc002luu.2	-	2	750	c.591C>T	c.(589-591)TTC>TTT	p.F197F	MOBKL2A_uc002luv.2_Silent_p.F197F	NM_130807	NP_570719	Q96BX8	MOL2A_HUMAN	MOB-LAK	197						intracellular	metal ion binding			lung(1)	1		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGATGAGGCCGAACTCCTTGA	0.622000													22	28					0	0	0.041601	0	0
MATK	4145	broad.mit.edu	37	19	3779721	3779721	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr19:3779721A>C	uc002lyt.2	-	9	1217	c.817T>G	c.(817-819)TTC>GTC	p.F273V	MATK_uc002lyv.2_Missense_Mutation_p.F274V|MATK_uc002lyu.2_Missense_Mutation_p.F232V|MATK_uc010dtq.2_Missense_Mutation_p.F273V	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	273	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGTCCAGGAAGGCCTGGGCT	0.687000													43	63					0	0	0.045515	0	0
MPND	84954	broad.mit.edu	37	19	4357346	4357346	+	Missense_Mutation	SNP	G	A	A	rs61730129		TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr19:4357346G>A	uc002mae.2	+	9	1160	c.1093G>A	c.(1093-1095)GCA>ACA	p.A365T	MPND_uc010dtx.2_RNA|MPND_uc002mag.2_Missense_Mutation_p.A315T|MPND_uc002maf.2_Missense_Mutation_p.A365T|MPND_uc002mah.2_Missense_Mutation_p.A253T|MPND_uc002mai.2_Missense_Mutation_p.A224T	NM_032868	NP_116257	Q8N594	MPND_HUMAN	MPN domain containing isoform 1	365	MPN.						peptidase activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACATCGACGCACAGATGGA	0.672000													3	48					0	0	0.009096	0	0
ZNF667	63934	broad.mit.edu	37	19	56953384	56953384	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr19:56953384T>C	uc002qnd.2	-	5	1142	c.980A>G	c.(979-981)GAG>GGG	p.E327G	ZNF667_uc010etl.2_Missense_Mutation_p.E109G|ZNF667_uc002qne.2_Missense_Mutation_p.E327G|ZNF667_uc010etm.2_Missense_Mutation_p.E270G	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	327					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		AAAAGGATTCTCTAAATGGTG	0.373000													8	119					0	0	0.058154	0	0
ZNF749	388567	broad.mit.edu	37	19	57956845	57956845	+	Missense_Mutation	SNP	A	G	G			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr19:57956845A>G	uc002qoq.2	+	3	2583	c.2329A>G	c.(2329-2331)AGG>GGG	p.R777G	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	777					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TACTGGAAAAAGGCCTTAGTG	0.393000													3	97					0	0	0.004672	0	0
AOX1	316	broad.mit.edu	37	2	201524011	201524011	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr2:201524011G>A	uc002uvx.2	+	28	3396	c.3295G>A	c.(3295-3297)GTA>ATA	p.V1099I	AOX1_uc010zhf.1_Missense_Mutation_p.V655I|AOX1_uc010fsu.2_Missense_Mutation_p.V465I	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	1099					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity	p.V1099I(1)		ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CGGTTTGGCAGTAAAGGTAAC	0.498000													4	132					0	0	0.009096	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								34	61					0	0	0.033182	0	0
CD93	22918	broad.mit.edu	37	20	23066171	23066171	+	Missense_Mutation	SNP	G	A	A	rs138932459		TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr20:23066171G>A	uc002wsv.2	-	1	807	c.659C>T	c.(658-660)GCG>GTG	p.A220V		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	220	Extracellular (Potential).		A -> V (in a colorectal cancer sample; somatic mutation).		cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding	p.A220V(1)		large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TACATTGGCCGCAGAGGCAAA	0.617000													4	87					0	0	0.014758	0	0
PI3	5266	broad.mit.edu	37	20	43804672	43804672	+	Missense_Mutation	SNP	G	C	C			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr20:43804672G>C	uc002xng.2	+	2	274	c.250G>C	c.(250-252)GCC>CCC	p.A84P		NM_002638	NP_002629	P19957	ELAF_HUMAN	elafin preproprotein	84	WAP.				copulation	proteinaceous extracellular matrix	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GATCCGGTGCGCCATGTTGAA	0.512000													29	55					0	0	0.069456	0	0
CNOT6L	246175	broad.mit.edu	37	4	78665985	78665985	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr4:78665985C>T	uc011ccd.1	-	7	735	c.604G>A	c.(604-606)GCT>ACT	p.A202T	CNOT6L_uc003hks.2_Missense_Mutation_p.A202T|CNOT6L_uc003hkt.1_Missense_Mutation_p.A45T|CNOT6L_uc011cce.1_Intron	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	202					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						TGCCGGGTAGCGTATTTATCA	0.393000													13	13					0	0	0.024245	0	0
NHEDC1	150159	broad.mit.edu	37	4	103822448	103822448	+	Silent	SNP	G	A	A			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr4:103822448G>A	uc003hww.2	-	12	1496	c.1374C>T	c.(1372-1374)TCC>TCT	p.S458S	NHEDC1_uc003hwu.2_Intron|NHEDC1_uc010ilm.2_Intron|NHEDC1_uc003hwv.2_Intron|NHEDC1_uc011cev.1_Silent_p.S231S	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	458						integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		AGTGGGGTGCGGAGACTCTTG	0.428000													15	216					0	0	0.021523	0	0
ADRA1B	147	broad.mit.edu	37	5	159344767	159344767	+	Missense_Mutation	SNP	G	T	T			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr5:159344767G>T	uc003lxt.1	+	1	1028	c.855G>T	c.(853-855)AAG>AAT	p.K285N		NM_000679	NP_000670	P35368	ADA1B_HUMAN	alpha-1B-adrenergic receptor	285	Cytoplasmic (By similarity).				cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			lung(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	AACTTTTTAAGTTCTCCAGGG	0.498000													43	48					2.61675e-31	2.84764e-31	0.045515	1	0
PKHD1	5314	broad.mit.edu	37	6	51747892	51747892	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr6:51747892T>C	uc003pah.1	-	46	7625	c.7349A>G	c.(7348-7350)AAG>AGG	p.K2450R	PKHD1_uc010jzn.1_Missense_Mutation_p.K433R|PKHD1_uc003pai.2_Missense_Mutation_p.K2450R	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2450	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGCACTTACCTTGTGGGCAAA	0.388000													12	19					0	0	0.024245	0	0
KEL	3792	broad.mit.edu	37	7	142658506	142658506	+	Missense_Mutation	SNP	A	C	C			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr7:142658506A>C	uc003wcb.2	-	3	374	c.164T>G	c.(163-165)TTG>TGG	p.L55W		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	55	Helical; Signal-anchor for type II membrane protein; (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GAGCAGGCCCAAAATCAGGAT	0.567000													14	12					0	0	0.028581	0	0
KCNB2	9312	broad.mit.edu	37	8	73848875	73848875	+	Missense_Mutation	SNP	C	T	T			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr8:73848875C>T	uc003xzb.2	+	3	1873	c.1285C>T	c.(1285-1287)CGC>TGC	p.R429C		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	429	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GGAGCAGAAACGCCAAGAGAA	0.438000													4	56					0	0	0.009096	0	0
EPPK1	83481	broad.mit.edu	37	8	144946590	144946590	+	Missense_Mutation	SNP	G	A	A			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr8:144946590G>A	uc003zaa.1	-	1	845	c.832C>T	c.(832-834)CGG>TGG	p.R278W		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	278	Plectin 6.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGGTAGCGCCGCACCTCGGCA	0.682000													3	20					0	0	0.009096	0	0
ATRX	546	broad.mit.edu	37	X	76849221	76849221	+	Missense_Mutation	SNP	T	C	C			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chrX:76849221T>C	uc004ecp.3	-	26	6287	c.6055A>G	c.(6055-6057)AAA>GAA	p.K2019E	ATRX_uc004ecq.3_Missense_Mutation_p.K1981E|ATRX_uc004eco.3_Missense_Mutation_p.K1804E	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2019					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AGTACCATTTTCCCAGAATGC	0.363000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						44	9					0	0	0.048971	0	0
ATP11C	286410	broad.mit.edu	37	X	138857058	138857058	+	Silent	SNP	T	C	C			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chrX:138857058T>C	uc004faz.2	-	19	2115	c.2016A>G	c.(2014-2016)AAA>AAG	p.K672K	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Silent_p.K672K	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	672	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					GCACCCAGACTTTCAGGCCTG	0.483000													5	46					0	0	0.029380	0	0
CLIP1	6249	broad.mit.edu	37	12	122812690	122812691	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr12:122812690_122812691insT	uc001ucg.1	-	16	3158_3159	c.3052_3053insA	c.(3052-3054)AGCfs	p.S1018fs	CLIP1_uc001uch.1_Frame_Shift_Ins_p.S1007fs|CLIP1_uc001uci.1_Frame_Shift_Ins_p.S972fs|CLIP1_uc001ucj.1_Frame_Shift_Ins_p.S593fs	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1018	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTGGTTGTGGCTTGTTTCCATT	0.505													9	135	---	---	---	---					
ADAM6	8755	broad.mit.edu	37	14	106774086	106774087	+	Splice_Site	INS	-	AGTAATACACGGCA	AGTAATACACGGCA			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr14:106774086_106774087insAGTAATACACGGCA	uc010tyt.1	-	430		c.15674_splice	c.e430+1							Parts of antibodies, mostly variable regions.												0						GCCTCTTGCACGTGTCCTCAGC	0.550													2	4	---	---	---	---					
SLFN11	91607	broad.mit.edu	37	17	33690253	33690273	+	In_Frame_Del	DEL	GGTCAGCAGGATCCGAGTTTG	-	-			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr17:33690253_33690273delGGTCAGCAGGATCCGAGTTTG	uc010ctp.2	-	4	996_1016	c.554_574delCAAACTCGGATCCTGCTGACC	c.(553-576)CCAAACTCGGATCCTGCTGACCTA>CTA	p.PNSDPAD185del	SLFN11_uc010ctq.2_In_Frame_Del_p.PNSDPAD185del|SLFN11_uc002hjh.3_In_Frame_Del_p.PNSDPAD185del|SLFN11_uc002hjg.3_In_Frame_Del_p.PNSDPAD185del|SLFN11_uc010ctr.2_In_Frame_Del_p.PNSDPAD185del	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	185_191						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGGAAAATTAGGTCAGCAGGATCCGAGTTTGGGTCAGCAGG	0.412													20	134	---	---	---	---					
CHERP	10523	broad.mit.edu	37	19	16640581	16640583	+	In_Frame_Del	DEL	TGC	-	-			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr19:16640581_16640583delTGC	uc002nei.1	-	8	1079_1081	c.1005_1007delGCA	c.(1003-1008)CAGCAA>CAA	p.335_336QQ>Q	MED26_uc002nee.2_Intron	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	335_336	Gln-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						ctgctgctgttgctgctgctgct	0.552													7	50	---	---	---	---					
TBC1D17	79735	broad.mit.edu	37	19	50387777	50387777	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr19:50387777delG	uc002pqo.2	+	12	1457	c.1305delG	c.(1303-1305)GTGfs	p.V435fs	TBC1D17_uc010ybg.1_Frame_Shift_Del_p.V402fs|TBC1D17_uc002pqp.2_Frame_Shift_Del_p.V86fs|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_Frame_Shift_Del_p.V86fs|TBC1D17_uc002pqs.2_RNA	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	435	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		AGAACGAGGTGGATGCTTTCT	0.597													40	113	---	---	---	---					
MAPK8IP2	23542	broad.mit.edu	37	22	51044326	51044326	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HT-7690-01A-11D-2253-08	TCGA-HT-7690-10A-01D-2253-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c74b94d-14f8-4e14-a9ec-da0a310c2da0	1edb908b-2481-4655-bdfc-34ebeba029ae	g.chr22:51044326delC	uc003bmx.2	+	9	2205	c.2088delC	c.(2086-2088)CACfs	p.H696fs	MAPK8IP2_uc003bmy.2_Frame_Shift_Del_p.H669fs|MAPK8IP2_uc011asc.1_Frame_Shift_Del_p.H50fs	NM_012324	NP_036456	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting	696	PID.				behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			large_intestine(2)|central_nervous_system(1)	3		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGCCCTGCCACCAGGGCAACG	0.682													2	4	---	---	---	---					
