Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
HTR1D	3352	broad.mit.edu	37	1	23520602	23520602	+	Silent	SNP	G	C	C			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr1:23520602G>C	uc001bgn.2	-	1	621	c.111C>G	c.(109-111)CTC>CTG	p.L37L		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	37	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	GGGAGATCTTGAGCGCCTGGA	0.567000													9	126					0	0	0	0
GPATCH3	63906	broad.mit.edu	37	1	27226896	27226896	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr1:27226896A>G	uc001bne.2	-	1	67	c.38T>C	c.(37-39)GTT>GCT	p.V13A	GPATCH3_uc009vsp.1_5'UTR	NM_022078	NP_071361	Q96I76	GPTC3_HUMAN	G patch domain containing 3	13						intracellular	nucleic acid binding				0		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.97e-51)|OV - Ovarian serous cystadenocarcinoma(117;9.55e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|STAD - Stomach adenocarcinoma(196;0.000595)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|READ - Rectum adenocarcinoma(331;0.0419)		TACCAGGTAAACTGTCGCCTC	0.592000													3	68					0	0	0	0
JAK1	3716	broad.mit.edu	37	1	65307005	65307005	+	Missense_Mutation	SNP	C	G	G	rs67572613		TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr1:65307005C>G	uc001dbu.1	-	19	2821	c.2572G>C	c.(2572-2574)GAA>CAA	p.E858Q	JAK1_uc009wam.1_Missense_Mutation_p.E846Q|JAK1_uc009wal.1_Missense_Mutation_p.E35Q	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	858					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		GGTTTTTTTTCTGAAACAATA	0.473000			Mis		ALL								16	143					0	0	0	0
FCRLB	127943	broad.mit.edu	37	1	161697058	161697058	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr1:161697058C>G	uc001gbh.2	+	8	1121	c.887C>G	c.(886-888)TCC>TGC	p.S296C	FCRLB_uc009wus.2_Missense_Mutation_p.S296C|FCRLB_uc001gbj.2_Missense_Mutation_p.P248A|FCRLB_uc001gbk.2_Silent_p.L261L|FCRLB_uc001gbl.2_Missense_Mutation_p.P241A|FCRLB_uc001gbm.2_Silent_p.L254L|FCRLB_uc001gbi.2_Missense_Mutation_p.S296C|FCRLB_uc001gbn.3_Silent_p.L298L	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	296						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			GACCCGGCCTCCACCACCGCC	0.582000													3	47					0	0	0	0
GLUL	2752	broad.mit.edu	37	1	182355001	182355001	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr1:182355001C>T	uc001gpa.1	-	5	709	c.497G>A	c.(496-498)GGA>GAA	p.G166E	GLUL_uc010pnt.1_5'Flank|GLUL_uc001gpb.1_Missense_Mutation_p.G166E|GLUL_uc001gpc.1_Missense_Mutation_p.G166E|GLUL_uc001gpd.1_Missense_Mutation_p.G166E	NM_001033056	NP_001028228	P15104	GLNA_HUMAN	glutamine synthetase	166					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding				0					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	TCTGTCTGCTCCCACACCACA	0.512000													14	176					0	0	0	0
PAPSS2	9060	broad.mit.edu	37	10	89472868	89472868	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr10:89472868C>T	uc001kex.2	+	3	445	c.182C>T	c.(181-183)GCC>GTC	p.A61V	PAPSS2_uc001kew.2_Missense_Mutation_p.A61V|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	61	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		ATAAGTTTTGCCCTGGAGGAG	0.473000													5	281					0	0	0	0
TNKS2	80351	broad.mit.edu	37	10	93602119	93602119	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr10:93602119G>A	uc001khp.2	+	16	2327	c.2030G>A	c.(2029-2031)GGC>GAC	p.G677D		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	677					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				GATACCCAAGGCAGACATTCA	0.403000													5	104					0	0	0	0
PDCD11	22984	broad.mit.edu	37	10	105176373	105176373	+	Silent	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr10:105176373C>T	uc001kwy.1	+	13	1731	c.1644C>T	c.(1642-1644)TTC>TTT	p.F548F		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	548	S1 motif 6.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CACATGGCTTCATCATCAGGG	0.488000											OREG0020494	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	131					0	0	0	0
PPP2R2D	55844	broad.mit.edu	37	10	133769208	133769208	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr10:133769208A>G	uc001lks.2	+	7	1247	c.1004A>G	c.(1003-1005)TAT>TGT	p.Y335C	PPP2R2D_uc001lkr.2_Missense_Mutation_p.Y141C|PPP2R2D_uc001lkt.2_Missense_Mutation_p.Y141C|PPP2R2D_uc009yay.2_Missense_Mutation_p.Y203C	NM_018461	NP_060931	Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B,	368	WD 6.				cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			skin(1)	1		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		ACCGGGTCCTATAACAACTTC	0.602000													5	39					0	0	0	0
IGSF22	283284	broad.mit.edu	37	11	18743146	18743146	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr11:18743146C>T	uc009yht.2	-	4	504	c.314G>A	c.(313-315)GGC>GAC	p.G105D	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	105	Ig-like 1.									ovary(4)|large_intestine(2)|kidney(1)	7						GATGGGGATGCCGCTCTCCCT	0.592000											OREG0020822	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	201					0	0	0	0
C11orf54	28970	broad.mit.edu	37	11	93488478	93488478	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr11:93488478T>G	uc009ywi.2	+	7	764	c.433T>G	c.(433-435)TAC>GAC	p.Y145D	C11orf54_uc001pee.1_Intron|C11orf54_uc001pef.2_Missense_Mutation_p.Y145D|C11orf54_uc001peg.2_Missense_Mutation_p.Y145D|C11orf54_uc001peh.2_Missense_Mutation_p.Y145D|C11orf54_uc001pei.2_Missense_Mutation_p.Y126D|C11orf54_uc001pej.2_Missense_Mutation_p.Y126D|C11orf54_uc001pek.2_Missense_Mutation_p.Y34D	NM_014039	NP_054758	Q9H0W9	CK054_HUMAN	hypothetical protein LOC28970	145						nucleus	hydrolase activity, acting on ester bonds|protein binding|zinc ion binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ACTGGAGAAATACAGTGAGAA	0.423000													4	105					0	0	0	0
MLL	4297	broad.mit.edu	37	11	118390377	118390377	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr11:118390377G>T	uc001pta.2	+	32	11205	c.11182G>T	c.(11182-11184)GTG>TTG	p.V3728L	MLL_uc001ptb.2_Missense_Mutation_p.V3731L	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3728	FYR C-terminal.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TGATGCAGTTGTGTTCCTCAT	0.502000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								16	151					0.000566183	0.000691185	1	0
OR8D4	338662	broad.mit.edu	37	11	123777472	123777472	+	Missense_Mutation	SNP	T	A	A	rs139359205		TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr11:123777472T>A	uc010saa.1	+	1	334	c.334T>A	c.(334-336)TGC>AGC	p.C112S		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TATTTCTGAATGCTACATGCT	0.478000													11	249					0	0	0	0
ESYT1	23344	broad.mit.edu	37	12	56527377	56527377	+	Silent	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr12:56527377C>T	uc001sjq.2	+	12	1349	c.1299C>T	c.(1297-1299)TTC>TTT	p.F433F	ESYT1_uc001sjr.2_Silent_p.F433F	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	433						integral to membrane				ovary(4)|skin(1)	5						TCTAGTGGTTCCCTCTACAAG	0.458000													6	100					0	0	0	0
PITPNM2	57605	broad.mit.edu	37	12	123498545	123498545	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr12:123498545C>G	uc001uej.1	-	3	262	c.123G>C	c.(121-123)GAG>GAC	p.E41D	PITPNM2_uc001uek.1_Missense_Mutation_p.E41D|PITPNM2_uc009zxu.1_Missense_Mutation_p.E41D	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	41					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TCTCCAGGATCTCCACGCCGC	0.587000													4	108					0	0	0	0
HMGB1	3146	broad.mit.edu	37	13	31037677	31037677	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr13:31037677C>G	uc001usw.2	-	2	325	c.141G>C	c.(139-141)GAG>GAC	p.E47D	HMGB1_uc001usz.2_Missense_Mutation_p.E47D|HMGB1_uc001usv.2_Missense_Mutation_p.E47D|HMGB1_uc001usx.2_Missense_Mutation_p.E47D|HMGB1_uc001usy.2_Intron|HMGB1_uc001uta.1_Missense_Mutation_p.E47D	NM_002128	NP_002119	P09429	HMGB1_HUMAN	high-mobility group box 1	47	HMG box 1.				base-excision repair, DNA ligation|dendritic cell chemotaxis|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|inflammatory response to antigenic stimulus|innate immune response|myeloid dendritic cell activation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|neuron projection development|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	cell surface|condensed chromosome|extracellular space|nucleolus|nucleoplasm	chemoattractant activity|cytokine activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(1)	1		Lung SC(185;0.0257)		all cancers(112;0.072)|OV - Ovarian serous cystadenocarcinoma(117;0.177)|Lung(94;0.216)|GBM - Glioblastoma multiforme(144;0.232)		CCTTCCACCTCTCTGAGCACT	0.408000													5	243					0	0	0	0
HMGB1	3146	broad.mit.edu	37	13	31037728	31037728	+	Silent	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr13:31037728C>T	uc001usw.2	-	2	274	c.90G>A	c.(88-90)AAG>AAA	p.K30K	HMGB1_uc001usz.2_Silent_p.K30K|HMGB1_uc001usv.2_Silent_p.K30K|HMGB1_uc001usx.2_Silent_p.K30K|HMGB1_uc001usy.2_Missense_Mutation_p.S15N|HMGB1_uc001uta.1_Silent_p.K30K	NM_002128	NP_002119	P09429	HMGB1_HUMAN	high-mobility group box 1	30	HMG box 1.				base-excision repair, DNA ligation|dendritic cell chemotaxis|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|inflammatory response to antigenic stimulus|innate immune response|myeloid dendritic cell activation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|neuron projection development|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	cell surface|condensed chromosome|extracellular space|nucleolus|nucleoplasm	chemoattractant activity|cytokine activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(1)	1		Lung SC(185;0.0257)		all cancers(112;0.072)|OV - Ovarian serous cystadenocarcinoma(117;0.177)|Lung(94;0.216)|GBM - Glioblastoma multiforme(144;0.232)		CATCTGGGTGCTTCTTCTTAT	0.408000													6	196					0	0	0	0
RNASE11	122651	broad.mit.edu	37	14	21052160	21052160	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr14:21052160G>T	uc010ahv.2	-	2	659	c.474C>A	c.(472-474)TGC>TGA	p.C158*	RNASE11_uc010ahx.2_Nonsense_Mutation_p.C158*|RNASE11_uc010ahw.2_Nonsense_Mutation_p.C158*|RNASE11_uc001vxs.2_Nonsense_Mutation_p.C158*	NM_145250	NP_660293	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	158						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(3)	3	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		TAGTGAACTGGCACACTGTAT	0.488000													9	85					0.00448238	0.0052668	1	0
PLCB2	5330	broad.mit.edu	37	15	40591135	40591135	+	Silent	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr15:40591135C>T	uc001zld.2	-	9	1015	c.714G>A	c.(712-714)AAG>AAA	p.K238K	PLCB2_uc010bbo.2_Silent_p.K238K|PLCB2_uc010ucm.1_Silent_p.K238K	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	238					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		TCAGGTGCTCCTTCGTCATGT	0.577000													9	164					0	0	0	0
DNAH3	55567	broad.mit.edu	37	16	21136514	21136514	+	Silent	SNP	G	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr16:21136514G>A	uc010vbe.1	-	9	1386	c.1386C>T	c.(1384-1386)TCC>TCT	p.S462S	DNAH3_uc002die.2_Silent_p.S433S	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	462	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCATGAAAAGGGAAACGAGGT	0.453000													8	113					0	0	0	0
FTSJD1	55783	broad.mit.edu	37	16	71319121	71319121	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr16:71319121C>A	uc010cga.2	-	3	1109	c.703G>T	c.(703-705)GAT>TAT	p.D235Y	FTSJD1_uc002ezy.3_Missense_Mutation_p.D235Y|FTSJD1_uc002ezz.3_Missense_Mutation_p.D235Y	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	235		S-adenosyl-L-methionine (By similarity).				integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						AAACTCCCATCTGCAGTGACC	0.428000													19	75					9.7654e-05	0.000120783	1	0
SLFN12L	342615	broad.mit.edu	37	17	33806816	33806816	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr17:33806816G>A	uc002hjn.2	-	3	1379	c.500C>T	c.(499-501)GCC>GTC	p.A167V		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						GCTCAACGTGGCAATCTGCGG	0.433000													3	35					0	0	0	0
OR4D2	124538	broad.mit.edu	37	17	56247483	56247483	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr17:56247483C>A	uc010wnp.1	+	1	467	c.467C>A	c.(466-468)TCT>TAT	p.S156Y		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TTTGTCCACTCTATTGTCCAG	0.567000													12	120					3.07112e-06	3.90115e-06	1	0
MIR924	100126323	broad.mit.edu	37	18	37202131	37202131	+	RNA	SNP	G	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr18:37202131G>A	hsa-mir-924|MI0005716	-			c.9G>A			LOC647946_uc010xcj.1_Intron|LOC647946_uc002lal.1_Intron																	0						gacatcacaagactctattga	0.100000													4	75					0	0	0	0
ZNF676	163223	broad.mit.edu	37	19	22363822	22363822	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:22363822C>T	uc002nqs.1	-	3	1015	c.697G>A	c.(697-699)GCT>ACT	p.A233T		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	233	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CGATTAAAAGCTTTGCCACAT	0.363000													11	179					0	0	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010294	24010294	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:24010294C>G	uc002nrn.2	+	4	754	c.331C>G	c.(331-333)CAG>GAG	p.Q111E		NM_002295	NP_002286			ribosomal protein SA												0						CTTCACTAACCAGATCCAGGC	0.567000													4	39					0	0	0	0
DPY19L3	147991	broad.mit.edu	37	19	32923652	32923652	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:32923652G>C	uc002ntg.2	+	4	444	c.268G>C	c.(268-270)GAG>CAG	p.E90Q	DPY19L3_uc002nth.1_Missense_Mutation_p.E90Q	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	90						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					ATTCAGAACAGAGTGTGGCCT	0.408000													6	86					0	0	0	0
ZFP30	22835	broad.mit.edu	37	19	38126325	38126325	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:38126325G>C	uc002ogv.1	-	6	1633	c.1117C>G	c.(1117-1119)CAG>GAG	p.Q373E	ZFP30_uc002ogw.1_Missense_Mutation_p.Q373E|ZFP30_uc002ogx.1_Missense_Mutation_p.Q373E|ZFP30_uc010xtt.1_Missense_Mutation_p.Q372E	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	373	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTATTCTCTGATGGAGAGTT	0.408000													4	137					0	0	0	0
ACTN4	81	broad.mit.edu	37	19	39200969	39200969	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:39200969C>G	uc002oja.1	+	8	865	c.806C>G	c.(805-807)TCA>TGA	p.S269*	ACTN4_uc010egc.1_Nonsense_Mutation_p.S269*	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	269	Actin-binding.|CH 2.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CATGCCTTTTCAGGAGCGCAG	0.607000													4	218					0	0	0	0
CACNG8	59283	broad.mit.edu	37	19	54466602	54466602	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:54466602G>A	uc002qcs.1	+	1	309	c.203G>A	c.(202-204)GGG>GAG	p.G68E		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	69					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		CCCCACCGCGGGGGCGGCGGC	0.716000													3	14					0	0	0	0
LILRA2	11027	broad.mit.edu	37	19	55085362	55085362	+	Missense_Mutation	SNP	C	T	T	rs145704089	byFrequency	TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr19:55085362C>T	uc002qgg.3	+	1	106	c.17C>T	c.(16-18)ACG>ATG	p.T6M	LILRA2_uc010ern.2_Missense_Mutation_p.T6M|LILRA2_uc002qgf.2_Missense_Mutation_p.T6M|LILRA2_uc010yfe.1_Missense_Mutation_p.T6M|LILRA2_uc010yff.1_Missense_Mutation_p.T6M|LILRA2_uc010ero.2_Missense_Mutation_p.T6M|LILRA2_uc010yfg.1_Missense_Mutation_p.T6M	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	6					defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CCCATCCTCACGGTCCTGATC	0.602000													13	159					0	0	0	0
SULT6B1	391365	broad.mit.edu	37	2	37410658	37410658	+	Splice_Site	SNP	C	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr2:37410658C>G	uc002rpu.2	-	3	220	c.199_splice	c.e3-1	p.R67_splice	SULT6B1_uc010yni.1_Splice_Site	NM_001032377	NP_001027549	Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member							cytoplasm	sulfotransferase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(82;0.248)				CTTTCATTCTCTTAAAAATAT	0.328000													3	105					0	0	0	0
IMMT	10989	broad.mit.edu	37	2	86374882	86374882	+	Silent	SNP	A	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr2:86374882A>G	uc002sqz.3	-	13	1864	c.1476T>C	c.(1474-1476)GAT>GAC	p.D492D	IMMT_uc002sqy.3_Silent_p.D233D|IMMT_uc002srb.3_Silent_p.D481D|IMMT_uc002sra.3_Silent_p.D491D|IMMT_uc010ytd.1_Silent_p.D480D|IMMT_uc010yte.1_Silent_p.D445D|IMMT_uc002src.1_Silent_p.D228D	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	492	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						CTCGCAAGTGATCAGTGTGGG	0.478000													8	128					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179436108	179436108	+	Silent	SNP	G	C	C			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr2:179436108G>C	uc010zfg.1	-	275	67271	c.67047C>G	c.(67045-67047)GTC>GTG	p.V22349V	uc002umo.2_Intron|uc002ump.1_RNA|TTN_uc010zfh.1_Silent_p.V16044V|TTN_uc010zfi.1_Silent_p.V15977V|TTN_uc010zfj.1_Silent_p.V15852V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23276							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGACAGTGTGACAACTGGAG	0.468000													6	157					0	0	0	0
VIL1	7429	broad.mit.edu	37	2	219313973	219313973	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr2:219313973C>G	uc002via.2	+	20	2463	c.2398C>G	c.(2398-2400)CAG>GAG	p.Q800E	VIL1_uc010zke.1_Missense_Mutation_p.Q489E|VIL1_uc002vib.2_Missense_Mutation_p.Q800E	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	800	Headpiece.|HP.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGATTTCACTCAGGCCTTTGG	0.493000													6	353					0	0	0	0
UGT1A8	54576	broad.mit.edu	37	2	234527158	234527158	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr2:234527158A>G	uc002vup.2	+	1	868	c.805A>G	c.(805-807)ATG>GTG	p.M269V	UGT1A8_uc010zmv.1_Missense_Mutation_p.M269V	NM_019076	NP_061949	Q9HAW9	UD18_HUMAN	UDP glycosyltransferase 1 family, polypeptide A8	269					drug metabolic process|fatty acid metabolic process|flavone metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme inhibitor activity|fatty acid binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|steroid binding			ovary(2)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		GATGCCCAATATGATCTTCAT	0.433000													33	408					0	0	0	0
NEURL2	140825	broad.mit.edu	37	20	44519216	44519216	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr20:44519216G>C	uc002xqg.1	-	1	686	c.415C>G	c.(415-417)CCA>GCA	p.P139A	C20orf165_uc002xqf.2_5'Flank|CTSA_uc002xqh.2_5'Flank|CTSA_uc002xqj.3_5'Flank|CTSA_uc002xqi.2_5'Flank|CTSA_uc010zxi.1_5'Flank|CTSA_uc002xqk.3_5'Flank	NM_080749	NP_542787	Q9BR09	NEUL2_HUMAN	neuralized-like protein 2	139	NHR.				intracellular signal transduction						0		Myeloproliferative disorder(115;0.0122)				AGGAGGGTTGGAGGTCGGCTG	0.697000													6	54					0	0	0	0
DHX30	22907	broad.mit.edu	37	3	47882464	47882464	+	Missense_Mutation	SNP	G	A	A	rs139889547		TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr3:47882464G>A	uc003cru.2	+	7	890	c.464G>A	c.(463-465)CGT>CAT	p.R155H	DHX30_uc003crs.2_Missense_Mutation_p.R116H|DHX30_uc003crt.2_Missense_Mutation_p.R116H|DHX30_uc010hjr.1_Missense_Mutation_p.R183H	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	155						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		AGCTGGTGGCGTCCGGAACCC	0.617000													7	53					0	0	0	0
NISCH	11188	broad.mit.edu	37	3	52505975	52505975	+	Missense_Mutation	SNP	T	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr3:52505975T>G	uc011beg.1	+	6	627	c.555T>G	c.(553-555)TGT>TGG	p.C185W	NISCH_uc003ded.3_Missense_Mutation_p.C185W|NISCH_uc003dec.1_Missense_Mutation_p.C185W	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	185	Necessary for homooligomerization and targeting to endosomes.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		ACTTCACCTGTCGCCTTAAGT	0.617000											OREG0015615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	64					0	0	0	0
FXR1	8087	broad.mit.edu	37	3	180666565	180666565	+	Missense_Mutation	SNP	T	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr3:180666565T>A	uc003fkq.2	+	6	498	c.476T>A	c.(475-477)ATT>AAT	p.I159N	FXR1_uc003fkp.2_Missense_Mutation_p.I74N|FXR1_uc003fkr.2_Missense_Mutation_p.I159N|FXR1_uc011bqj.1_Missense_Mutation_p.I73N|FXR1_uc003fks.2_Missense_Mutation_p.I73N|FXR1_uc011bqk.1_Missense_Mutation_p.I110N|FXR1_uc011bql.1_Missense_Mutation_p.I146N	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	159					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GCATGCAGAATTTTTTACCAT	0.303000													6	169					0	0	0	0
CPLX1	10815	broad.mit.edu	37	4	786392	786392	+	Silent	SNP	G	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:786392G>A	uc003gbi.2	-	3	227	c.36C>T	c.(34-36)GCC>GCT	p.A12A	CPLX1_uc003gbj.2_Silent_p.A12A	NM_006651	NP_006642	O14810	CPLX1_HUMAN	complexin 1	12					glutamate secretion	cytosol					0				Colorectal(103;0.187)		TGTCCTTGGTGGCCCCTGGTA	0.662000													11	93					0	0	0	0
TBC1D1	23216	broad.mit.edu	37	4	38138875	38138875	+	Silent	SNP	G	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:38138875G>A	uc003gtb.2	+	20	3769	c.3426G>A	c.(3424-3426)ACG>ACA	p.T1142T	TBC1D1_uc011byd.1_Silent_p.T1133T|TBC1D1_uc010ifd.2_Silent_p.T929T|TBC1D1_uc003gtd.2_Silent_p.T154T	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	1142						nucleus	Rab GTPase activator activity			ovary(1)	1						TGCTGCAGACGGTGGAGGAGC	0.642000													7	60					0	0	0	0
SHROOM3	57619	broad.mit.edu	37	4	77692006	77692006	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:77692006G>C	uc011cbx.1	+	10	6530	c.5577G>C	c.(5575-5577)GAG>GAC	p.E1859D	SHROOM3_uc003hkg.2_Missense_Mutation_p.E1637D	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1859	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CCCGTGTTGAGAATGTCCTTA	0.502000													6	157					0	0	0	0
EGF	1950	broad.mit.edu	37	4	110834553	110834553	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:110834553C>T	uc003hzy.3	+	1	514	c.62C>T	c.(61-63)TCA>TTA	p.S21L	EGF_uc011cfu.1_Missense_Mutation_p.S21L|EGF_uc011cfv.1_Missense_Mutation_p.S21L	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	21					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GTTAGTCTCTCAGCACCGCAG	0.428000													4	75					0	0	0	0
ANK2	287	broad.mit.edu	37	4	114279449	114279449	+	Silent	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:114279449C>T	uc003ibe.3	+	38	9775	c.9675C>T	c.(9673-9675)CTC>CTT	p.L3225L	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Silent_p.L527L|ANK2_uc011cgb.1_Silent_p.L3240L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3192					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCAAGGACCTCCCCACCGTGC	0.478000													10	106					0	0	0	0
ANK2	287	broad.mit.edu	37	4	114279897	114279897	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr4:114279897C>G	uc003ibe.3	+	38	10223	c.10123C>G	c.(10123-10125)CAG>GAG	p.Q3375E	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.Q677E|ANK2_uc011cgb.1_Missense_Mutation_p.Q3390E	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3342					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGTGGCTCCTCAGGGACAGGA	0.468000													9	103					0	0	0	0
RICTOR	253260	broad.mit.edu	37	5	38944564	38944564	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr5:38944564C>A	uc003jlp.2	-	36	4921	c.4897G>T	c.(4897-4899)GAG>TAG	p.E1633*	RICTOR_uc003jlo.2_Nonsense_Mutation_p.E1657*|RICTOR_uc010ivf.2_Nonsense_Mutation_p.E1310*	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1633					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					AGCCCAGTCTCATGACATTTA	0.323000													9	214					2.17888e-05	2.73086e-05	1	0
SPZ1	84654	broad.mit.edu	37	5	79616171	79616171	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr5:79616171C>T	uc003kgn.2	+	1	382	c.137C>T	c.(136-138)TCC>TTC	p.S46F	uc011ctk.1_RNA	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		TCCCCTTCCTCCTGGGGCTCT	0.403000													7	225					0	0	0	0
PITX1	5307	broad.mit.edu	37	5	134364577	134364577	+	Missense_Mutation	SNP	G	C	C			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr5:134364577G>C	uc010jea.2	-	3	1230	c.837C>G	c.(835-837)AAC>AAG	p.N279K	PITX1_uc011cxy.1_Missense_Mutation_p.N279K	NM_002653	NP_002644	P78337	PITX1_HUMAN	paired-like homeodomain transcription factor 1	279	Interacts with PIT-1 (By similarity).					nucleolus	sequence-specific DNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)		CTAGGCTCGAGTTGCACGTGT	0.677000													3	27					0	0	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140740003	140740003	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr5:140740003C>G	uc003ljs.1	+	1	301	c.301C>G	c.(301-303)CTG>GTG	p.L101V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Missense_Mutation_p.L101V	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	101	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGCAGCCTCTGTGTGTTCT	0.418000													9	140					0	0	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140784546	140784546	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr5:140784546G>A	uc003lkh.1	+	1	2027	c.2027G>A	c.(2026-2028)GGC>GAC	p.G676D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.G676D	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	676	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGACCTGGGCAGTCTTCAG	0.592000													9	136					0	0	0	0
KIFC1	3833	broad.mit.edu	37	6	33372879	33372879	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr6:33372879C>T	uc003oef.3	+	7	1457	c.1007C>T	c.(1006-1008)TCT>TTT	p.S336F	KIFC1_uc011drf.1_Missense_Mutation_p.S328F	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	336	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						CTGTTTCCCTCTGGCCCTGGT	0.682000													5	187					0	0	0	0
PHF3	23469	broad.mit.edu	37	6	64421505	64421505	+	Missense_Mutation	SNP	C	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr6:64421505C>G	uc003pep.1	+	15	4047	c.4021C>G	c.(4021-4023)CTA>GTA	p.L1341V	PHF3_uc003pen.2_Missense_Mutation_p.L1253V|PHF3_uc011dxs.1_Missense_Mutation_p.L610V	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1341					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TAGACCTAATCTATTGTTGGG	0.373000													13	197					0	0	0	0
SASH1	23328	broad.mit.edu	37	6	148855896	148855896	+	Missense_Mutation	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr6:148855896C>T	uc003qme.1	+	16	2429	c.1954C>T	c.(1954-1956)CCC>TCC	p.P652S	SASH1_uc011eeb.1_Missense_Mutation_p.P413S|SASH1_uc003qmf.1_Missense_Mutation_p.P62S	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	652	SAM 1.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GGAGCACATGCCCACTTTCCT	0.502000													4	132					0	0	0	0
RAET1G	353091	broad.mit.edu	37	6	150240360	150240360	+	Silent	SNP	G	C	C			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr6:150240360G>C	uc010kii.1	-	3	518	c.450C>G	c.(448-450)CTC>CTG	p.L150L	uc003qni.1_RNA|RAET1G_uc003qnm.2_RNA	NM_001001788	NP_001001788	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G precursor	150	Extracellular (Potential).|MHC class I alpha-2 like.				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		CTGAGTCAAAGAGGAGGAAGA	0.493000													18	183					0	0	0	0
ESR1	2099	broad.mit.edu	37	6	152163869	152163869	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr6:152163869A>G	uc003qom.3	+	4	960	c.590A>G	c.(589-591)TAT>TGT	p.Y197C	ESR1_uc010kin.2_Missense_Mutation_p.Y197C|ESR1_uc010kio.2_Missense_Mutation_p.Y197C|ESR1_uc010kip.2_Missense_Mutation_p.Y197C|ESR1_uc003qon.3_Missense_Mutation_p.Y197C|ESR1_uc003qoo.3_Missense_Mutation_p.Y197C|ESR1_uc010kiq.2_Intron|ESR1_uc010kir.2_Intron|ESR1_uc011eet.1_RNA|ESR1_uc011eeu.1_RNA|ESR1_uc011eev.1_Missense_Mutation_p.Y24C|ESR1_uc011eew.1_Missense_Mutation_p.M29V	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	197	NR C4-type.|Nuclear receptor.|Mediates interaction with DNTTIP2.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	GGCTACCATTATGGAGTCTGG	0.453000													8	99					0	0	0	0
TYW1B	441250	broad.mit.edu	37	7	72040531	72040531	+	Missense_Mutation	SNP	G	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr7:72040531G>T	uc011kej.1	-	17	2118	c.1959C>A	c.(1957-1959)GAC>GAA	p.D653E	TYW1B_uc011keh.1_Intron|TYW1B_uc011kei.1_Missense_Mutation_p.D279E	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	653					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GATGTCTTGTGTCCTTGGGAT	0.408000													5	101					0.00116845	0.0013903	1	0
MAGI2	9863	broad.mit.edu	37	7	77885568	77885568	+	Missense_Mutation	SNP	C	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr7:77885568C>A	uc003ugx.2	-	10	1993	c.1739G>T	c.(1738-1740)GGC>GTC	p.G580V	MAGI2_uc003ugy.2_Missense_Mutation_p.G580V|MAGI2_uc010ldx.1_Missense_Mutation_p.G189V|MAGI2_uc010ldy.1_Missense_Mutation_p.G189V|MAGI2_uc011kgr.1_Missense_Mutation_p.G412V|MAGI2_uc011kgs.1_Missense_Mutation_p.G417V	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	580						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGGATACGTGCCGTCTAGCTG	0.507000													4	60					0.000602214	0.000725746	1	0
ZNF804B	219578	broad.mit.edu	37	7	88964688	88964688	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr7:88964688A>T	uc011khi.1	+	4	2930	c.2392A>T	c.(2392-2394)AAA>TAA	p.K798*		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	798						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AAAATACTCAAAACGTAGATA	0.348000										HNSCC(36;0.09)			9	72					0	0	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761232	92761232	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr7:92761232G>T	uc003umh.1	-	5	5269	c.4053C>A	c.(4051-4053)TAC>TAA	p.Y1351*	SAMD9L_uc003umj.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc003umi.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc010lfb.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc003umk.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc010lfc.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc010lfd.1_Nonsense_Mutation_p.Y1351*|SAMD9L_uc011khx.1_3'UTR	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1351										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TAGCATCTTTGTAGTTTGGAT	0.388000													40	232					5.59293e-11	7.20185e-11	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117432666	117432666	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr7:117432666A>G	uc003vjf.2	-	4	676	c.584T>C	c.(583-585)GTA>GCA	p.V195A		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	195	Potential.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TTTGGCCATTACGTCTTCGAG	0.483000													3	159					0	0	0	0
PTTG3P	26255	broad.mit.edu	37	8	67680002	67680002	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr8:67680002G>A	uc011leu.1	-	1	239	c.239C>T	c.(238-240)CCC>CTC	p.P80L	SGK3_uc003xwp.2_Intron|SGK3_uc003xwr.2_Intron	NR_002734				RecName: Full=Securin-3; AltName: Full=Pituitary tumor transforming gene 3 protein;          Short=hPTTG3; AltName: Full=rcPTTG1;												0						TTGTTTGAGGGGTCCATTGGT	0.433000													6	121					0	0	0	0
GNE	10020	broad.mit.edu	37	9	36227321	36227321	+	Missense_Mutation	SNP	T	C	C			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr9:36227321T>C	uc010mlh.2	-	7	1420	c.1205A>G	c.(1204-1206)CAT>CGT	p.H402R	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Missense_Mutation_p.H402R|GNE_uc011lpl.1_Missense_Mutation_p.H292R|GNE_uc010mli.2_Missense_Mutation_p.H433R|GNE_uc010mlj.2_Missense_Mutation_p.H397R	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	402	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			TTCAAGAATATGGTCAATATC	0.408000													7	102					0	0	0	0
Unknown	0	broad.mit.edu	37	9	43861012	43861012	+	RNA	SNP	C	T	T			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr9:43861012C>T	uc004acz.1	+	11		c.1836C>T								Homo sapiens cDNA FLJ30083 fis, clone BGGI12001097, weakly similar to Homo sapiens contactin associated protein (Caspr) mRNA.																		GCAGACTCCGCGTGGACGGTG	0.647000													3	7					0	0	0	0
USP9X	8239	broad.mit.edu	37	X	41000632	41000632	+	Missense_Mutation	SNP	A	G	G			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chrX:41000632A>G	uc004dfb.2	+	9	1742	c.1109A>G	c.(1108-1110)CAT>CGT	p.H370R	USP9X_uc004dfc.2_Missense_Mutation_p.H370R	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	370					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TACTATACTCATCGACATGGT	0.353000													7	33					0	0	0	0
CACNA1F	778	broad.mit.edu	37	X	49065126	49065126	+	Missense_Mutation	SNP	G	A	A			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chrX:49065126G>A	uc004dnb.2	-	43	5067	c.5005C>T	c.(5005-5007)CCC>TCC	p.P1669S	CACNA1F_uc010nip.2_Missense_Mutation_p.P1658S	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1669	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CGAGCTGAGGGCTGGGAGACC	0.567000													3	55					0	0	0	0
Unknown	0	broad.mit.edu	37	10	42400410	42400410	+	IGR	DEL	C	-	-	rs74186261		TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr10:42400410delC								None (None upstream) : LOC441666 (426905 downstream)																							aacgggatttcttcacataat	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	14	85281016	85281023	+	IGR	DEL	CCTCCCTC	-	-	rs76839618		TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr14:85281016_85281023delCCTCCCTC								None (None upstream) : FLRT2 (715465 downstream)																							tcccttccttcctccctccctccctccc	0.125													---	---	---							
Unknown	0	broad.mit.edu	37	16	15457565	15457566	+	IGR	DEL	AC	-	-			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr16:15457565_15457566delAC								PDXDC1 (224370 upstream) : MPV17L (32045 downstream)																							GAGTGAGCAGACACACTCGGGA	0.446													---	---	---							
TP53	7157	broad.mit.edu	37	17	7578222	7578223	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr17:7578222_7578223delTC	uc002gim.2	-	6	820_821	c.626_627delGA	c.(625-627)AGAfs	p.R209fs	TP53_uc002gig.1_Frame_Shift_Del_p.R209fs|TP53_uc002gih.2_Frame_Shift_Del_p.R209fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.R77fs|TP53_uc010cng.1_Frame_Shift_Del_p.R77fs|TP53_uc002gii.1_Frame_Shift_Del_p.R77fs|TP53_uc010cnh.1_Frame_Shift_Del_p.R209fs|TP53_uc010cni.1_Frame_Shift_Del_p.R209fs|TP53_uc002gij.2_Frame_Shift_Del_p.R209fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.R116fs|TP53_uc002gio.2_Frame_Shift_Del_p.R77fs|TP53_uc010vug.1_Frame_Shift_Del_p.R170fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	209	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> I (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R209fs*6(31)|p.R209*(9)|p.0?(7)|p.R209T(3)|p.R209K(3)|p.R209fs*35(2)|p.D207fs*6(2)|p.R209fs*38(2)|p.K164_P219del(1)|p.E204_N210delEYLDDRN(1)|p.R209fs*36(1)|p.D207_R213delDDRNTFR(1)|p.D208_V216delDRNTFRHSV(1)|p.D208fs*1(1)|p.N210fs*7(1)|p.R209R(1)|p.R209S(1)|p.R209I(1)|p.R209_R213delRNTFR(1)|p.D207_V216del10(1)|p.R209fs*7(1)|p.R209fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAAAGTGTTTCTGTCATCCAA	0.535		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---							
Unknown	0	broad.mit.edu	37	18	57863634	57863635	+	IGR	INS	-	G	G	rs144729393	by1000genomes	TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr18:57863634_57863635insG								PMAIP1 (292096 upstream) : MC4R (174929 downstream)																							GTGAGACCCCCCCCAGTAACAG	0.485													---	---	---							
Unknown	0	broad.mit.edu	37	21	37667354	37667354	+	IGR	DEL	A	-	-	rs71326671		TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr21:37667354delA								DOPEY2 (783 upstream) : MORC3 (25133 downstream)																							TTTCTTCtttaaaaaaaaaaa	0.289													---	---	---							
CELSR1	9620	broad.mit.edu	37	22	46777939	46777939	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chr22:46777939delG	uc003bhw.1	-	21	6892	c.6892delC	c.(6892-6894)CTGfs	p.L2298fs	CELSR1_uc011arc.1_Frame_Shift_Del_p.L619fs	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2298	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GGCCTCAGCAGGGGGCCTTCT	0.667													---	---	---							
Unknown	0	broad.mit.edu	37	X	448557	448560	+	IGR	DEL	GGAA	-	-			TCGA-CN-5358-01A-01D-1512-08	TCGA-CN-5358-10A-01D-1512-08									Somatic	Phase_I	Capture				Illumina GAIIx	498c0b1f-678f-4f70-b0d1-aad89bfa2a23	125882f9-462f-4cc5-935e-4b8b253c1cce	g.chrX:448557_448560delGGAA								PPP2R3B (100930 upstream) : SHOX (136519 downstream)																							GAGACaggatggaaggaaggaagg	0.025													---	---	---							
