Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CAMTA1	23261	broad.mit.edu	37	1	7724942	7724942	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:7724942G>A	uc001aoi.2	+	9	2542	c.2335G>A	c.(2335-2337)GAC>AAC	p.D779N		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CCTGATCAACGACTTCATCTC	0.647000													27	313					0	0	0	0
MASP2	10747	broad.mit.edu	37	1	11090260	11090260	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:11090260C>A	uc001aru.2	-	10	1291	c.1270G>T	c.(1270-1272)GAA>TAA	p.E424*		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	424	Sushi 2.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		AGTGATTTTTCTCCTTTGGAG	0.423000													15	46					1.5739e-10	1.74133e-10	1	0
ARHGEF10L	55160	broad.mit.edu	37	1	17953907	17953907	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:17953907A>G	uc001ban.2	+	15	1652	c.1493A>G	c.(1492-1494)GAG>GGG	p.E498G	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.E459G|ARHGEF10L_uc001bao.2_Missense_Mutation_p.E459G|ARHGEF10L_uc001bap.2_Missense_Mutation_p.E459G|ARHGEF10L_uc010ocr.1_Missense_Mutation_p.E256G|ARHGEF10L_uc001baq.2_Missense_Mutation_p.E264G|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.E276G|ARHGEF10L_uc001bar.2_Missense_Mutation_p.E206G|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	498	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		ACGCTGGCTGAGAAGCTGAAC	0.627000													11	42					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75039018	75039018	+	Silent	SNP	T	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:75039018T>C	uc001dgg.2	-	14	2595	c.2376A>G	c.(2374-2376)AAA>AAG	p.K792K		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	792	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTGCCTCCCCTTTTCCCTGTA	0.522000													3	149					0	0	0	0
USP33	23032	broad.mit.edu	37	1	78183606	78183606	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:78183606G>C	uc001dht.2	-	18	2304	c.1957C>G	c.(1957-1959)CAA>GAA	p.Q653E	USP33_uc001dhs.2_Missense_Mutation_p.Q374E|USP33_uc001dhu.2_Missense_Mutation_p.Q622E|USP33_uc001dhv.2_Missense_Mutation_p.Q458E|USP33_uc001dhw.2_Missense_Mutation_p.Q645E	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	653					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						GTCACAATTTGAGCTGGACTA	0.363000													5	80					0	0	0	0
NEXN	91624	broad.mit.edu	37	1	78383306	78383306	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:78383306A>T	uc001dic.3	+	3	380	c.83A>T	c.(82-84)AAG>ATG	p.K28M	NEXN_uc001dia.3_Missense_Mutation_p.K28M|NEXN_uc009wcb.1_Intron|NEXN_uc001dib.3_Intron|NEXN_uc001did.1_5'Flank|NEXN_uc001dif.1_5'Flank	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	28					regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		AAACTTGGCAAGGGTGATGTA	0.338000													6	61					0	0	0	0
HS2ST1	9653	broad.mit.edu	37	1	87558299	87558299	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:87558299T>C	uc010osk.1	+	4	920	c.535T>C	c.(535-537)TTT>CTT	p.F179L	HS2ST1_uc001dmc.3_Missense_Mutation_p.F179L|LOC339524_uc001dme.1_Missense_Mutation_p.F140L	NM_012262	NP_036394	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1 isoform	179	Lumenal (Potential).					Golgi membrane|integral to membrane				central_nervous_system(1)	1		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		CTTTCTGAGATTTGGAGATGA	0.299000													7	69					0	0	0	0
PKN2	5586	broad.mit.edu	37	1	89271671	89271671	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:89271671G>C	uc001dmn.2	+	12	2116	c.1774G>C	c.(1774-1776)GAA>CAA	p.E592Q	PKN2_uc001dmm.1_3'UTR|PKN2_uc010osp.1_Missense_Mutation_p.E576Q|PKN2_uc010osq.1_Missense_Mutation_p.E435Q|PKN2_uc009wcv.2_Missense_Mutation_p.E544Q|PKN2_uc010osr.1_Missense_Mutation_p.E257Q	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	592					signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		TGAATCTTCTGAATTAAGAGT	0.388000													8	50					0	0	0	0
DPYD	1806	broad.mit.edu	37	1	97981411	97981411	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:97981411C>A	uc001drv.2	-	13	1748	c.1611G>T	c.(1609-1611)ATG>ATT	p.M537I		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	537					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TCAATCCGGCCATTTCTACAC	0.438000													5	51					1.024e-07	1.10933e-07	1	0
TRIM33	51592	broad.mit.edu	37	1	114948369	114948369	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:114948369C>G	uc001eew.2	-	15	2515	c.2431G>C	c.(2431-2433)GAG>CAG	p.E811Q	TRIM33_uc010owr.1_Missense_Mutation_p.E425Q|TRIM33_uc010ows.1_Missense_Mutation_p.E443Q|TRIM33_uc001eex.2_Missense_Mutation_p.E811Q|TRIM33_uc001eey.1_Missense_Mutation_p.E6Q	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	811			E -> K (in a lung adenocarcinoma sample; somatic mutation).		negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding	p.E811K(2)		lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGCTACTCTCAGGACTGCTC	0.373000			T	RET	papillary thyroid								3	92					0	0	0	0
WDR3	10885	broad.mit.edu	37	1	118495242	118495242	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:118495242A>G	uc010oxe.1	+	19	2174	c.2108A>G	c.(2107-2109)GAG>GGG	p.E703G	WDR3_uc001ehi.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	703	WD 13.					nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		AGACTTTGGGAGAGAACAAGG	0.463000													3	122					0	0	0	0
HIST2H3D	653604	broad.mit.edu	37	1	149784913	149784913	+	Silent	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:149784913C>G	uc010pbl.1	-	1	324	c.324G>C	c.(322-324)ACG>ACC	p.T108T	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	108					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						CGCACAGGTTCGTGTCTTCGA	0.627000													9	39					0	0	0	0
FCRL5	83416	broad.mit.edu	37	1	157497570	157497570	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:157497570C>T	uc001fqu.2	-	9	1955	c.1797G>A	c.(1795-1797)TGG>TGA	p.W599*	FCRL5_uc009wsm.2_Nonsense_Mutation_p.W599*|FCRL5_uc010phv.1_Nonsense_Mutation_p.W599*|FCRL5_uc010phw.1_Nonsense_Mutation_p.W514*	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	599	Extracellular (Potential).|Ig-like C2-type 6.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CATGATAAAACCAGTACAGGA	0.582000													21	85					0	0	0	0
CD1D	912	broad.mit.edu	37	1	158151354	158151354	+	Silent	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:158151354C>T	uc001frr.2	+	3	670	c.171C>T	c.(169-171)AGC>AGT	p.S57S	CD1D_uc009wsr.1_Silent_p.S57S|CD1D_uc009wss.2_Silent_p.S57S|CD1D_uc009wst.1_5'UTR	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	57	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					AGACGCACAGCTGGAGCAACG	0.632000													50	145					0	0	0	0
KIFAP3	22920	broad.mit.edu	37	1	170001123	170001123	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr1:170001123C>G	uc001ggv.2	-	8	1016	c.745G>C	c.(745-747)GAT>CAT	p.D249H		NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	249					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGGTCTTCATCAAGTAAACAA	0.333000													10	82					0	0	0	0
MYO3A	53904	broad.mit.edu	37	10	26482144	26482144	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:26482144A>T	uc001isn.2	+	32	4809	c.4449A>T	c.(4447-4449)AAA>AAT	p.K1483N	MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1483					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GTGTCTGTAAAGGAGAGGAGC	0.333000													3	30					0	0	0	0
PARD3	56288	broad.mit.edu	37	10	34671564	34671564	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:34671564G>C	uc010qej.1	-	9	1303	c.1303C>G	c.(1303-1305)CCA>GCA	p.P435A	PARD3_uc010qek.1_Missense_Mutation_p.P435A|PARD3_uc010qel.1_Missense_Mutation_p.P435A|PARD3_uc010qem.1_Missense_Mutation_p.P435A|PARD3_uc010qen.1_Missense_Mutation_p.P435A|PARD3_uc010qeo.1_Missense_Mutation_p.P435A|PARD3_uc010qep.1_Missense_Mutation_p.P391A|PARD3_uc010qeq.1_Missense_Mutation_p.P391A|PARD3_uc001ixo.1_Missense_Mutation_p.P165A|PARD3_uc001ixp.1_Missense_Mutation_p.P300A|PARD3_uc001ixq.1_Missense_Mutation_p.P435A|PARD3_uc001ixr.1_Missense_Mutation_p.P435A|PARD3_uc001ixt.1_Missense_Mutation_p.P256A|PARD3_uc001ixu.1_Missense_Mutation_p.P391A|PARD3_uc001ixs.1_Missense_Mutation_p.P88A	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	435					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				GCCGAGGCTGGAGCGGATGGT	0.502000													3	75					0	0	0	0
ARID5B	84159	broad.mit.edu	37	10	63759919	63759919	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:63759919T>C	uc001jlt.1	+	4	598	c.572T>C	c.(571-573)CTG>CCG	p.L191P	ARID5B_uc010qil.1_Missense_Mutation_p.L191P	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	191					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CGCTCGATGCTGAAACGCATC	0.532000													3	67					0	0	0	0
SFXN4	119559	broad.mit.edu	37	10	120917410	120917410	+	Silent	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:120917410G>A	uc001leb.2	-	8	489	c.444C>T	c.(442-444)TTC>TTT	p.F148F	SFXN4_uc001ldy.2_Silent_p.F32F|SFXN4_uc001ldz.2_Silent_p.F32F|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	148	Helical; (Potential).				iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		TGATGCTGTTGAACGCTGCCA	0.418000													9	60					0	0	0	0
MKI67	4288	broad.mit.edu	37	10	129907526	129907526	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:129907526C>G	uc001lke.2	-	13	2773	c.2578G>C	c.(2578-2580)GAT>CAT	p.D860H	MKI67_uc001lkf.2_Missense_Mutation_p.D500H|MKI67_uc009yav.1_Missense_Mutation_p.D435H|MKI67_uc009yaw.1_Missense_Mutation_p.D10H	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	860					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTCTCAGTATCTGAAGTTTTT	0.433000													18	171					0	0	0	0
EBF3	253738	broad.mit.edu	37	10	131761669	131761669	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:131761669C>A	uc001lki.1	-	2	312	c.253G>T	c.(253-255)GAA>TAA	p.E85*	EBF3_uc010qur.1_Nonsense_Mutation_p.E71*	NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	85					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GCGGTCCTTTCAATCTCCACC	0.557000													26	122					1.39806e-14	1.58041e-14	1	0
MUC6	4588	broad.mit.edu	37	11	1028716	1028716	+	Silent	SNP	G	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr11:1028716G>T	uc001lsw.2	-	13	1572	c.1521C>A	c.(1519-1521)CTC>CTA	p.L507L		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	507	VWFD 2.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCTGGACCACGAGCTCCAGCC	0.642000													4	19					0.00024832	0.000261743	1	0
LRRC4C	57689	broad.mit.edu	37	11	40137506	40137506	+	Silent	SNP	T	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr11:40137506T>G	uc001mxa.1	-	2	2301	c.337A>C	c.(337-339)AGA>CGA	p.R113R	LRRC4C_uc001mxc.1_Silent_p.R109R|LRRC4C_uc001mxd.1_Silent_p.R109R|LRRC4C_uc001mxb.1_Silent_p.R109R	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	113	LRR 2.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TCAATGGTTCTGATATGGTTC	0.438000													16	45					0	0	0	0
OR5M8	219484	broad.mit.edu	37	11	56258421	56258421	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr11:56258421G>T	uc001nix.1	-	1	426	c.426C>A	c.(424-426)TTC>TTA	p.F142L		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					CCGTGATGAGGAAGGAGCACA	0.512000													19	85					5.03518e-11	5.61063e-11	1	0
CPSF7	79869	broad.mit.edu	37	11	61196680	61196680	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr11:61196680T>A	uc001nrq.2	-	2	162	c.28A>T	c.(28-30)ATA>TTA	p.I10L	SDHAF2_uc001nrt.2_5'Flank|CPSF7_uc001nro.2_Missense_Mutation_p.I10L|CPSF7_uc001nrp.2_Missense_Mutation_p.I53L|CPSF7_uc001nrr.2_Missense_Mutation_p.I10L|CPSF7_uc001nrs.1_5'UTR|CPSF7_uc009ynp.2_Missense_Mutation_p.I10L	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	10					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TCAGCATATATATCAATCAAG	0.478000													35	212					0	0	0	0
SLC3A2	6520	broad.mit.edu	37	11	62655847	62655847	+	Silent	SNP	G	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr11:62655847G>T	uc001nwd.2	+	12	1799	c.1575G>T	c.(1573-1575)CGG>CGT	p.R525R	SLC3A2_uc001nwb.2_Silent_p.R556R|SLC3A2_uc001nwc.2_Silent_p.R526R|SLC3A2_uc001nwe.2_Silent_p.R494R|SLC3A2_uc001nwf.2_Silent_p.R463R|SLC3A2_uc001nwg.2_Silent_p.R424R	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	525	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						TGTTCCGGCGGCTGAGTGACC	0.587000													22	69					1.50039e-11	1.68389e-11	1	0
LIMA1	51474	broad.mit.edu	37	12	50571764	50571764	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr12:50571764C>T	uc001rwj.3	-	11	1537	c.1363G>A	c.(1363-1365)GGC>AGC	p.G455S	LIMA1_uc001rwg.3_Missense_Mutation_p.G153S|LIMA1_uc001rwh.3_Missense_Mutation_p.G294S|LIMA1_uc001rwi.3_Missense_Mutation_p.G296S|LIMA1_uc001rwk.3_Missense_Mutation_p.G456S|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	455					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						TGCCCAAAGCCTTCATCATAG	0.418000													8	163					0	0	0	0
CEP290	80184	broad.mit.edu	37	12	88535027	88535027	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr12:88535027G>A	uc001tar.2	-	2	402	c.58C>T	c.(58-60)CGT>TGT	p.R20C	CEP290_uc009zsl.1_5'Flank|TMTC3_uc009zsm.2_5'Flank|TMTC3_uc001tau.2_5'Flank	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	20					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						TCTTCTTGACGGGGCAGGTCA	0.313000													14	27					0	0	0	0
FRY	10129	broad.mit.edu	37	13	32653003	32653003	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr13:32653003C>A	uc001utx.2	+	2	599	c.103C>A	c.(103-105)CCG>ACG	p.P35T	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	35					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CATCAAGCCTCCGGTTCCACC	0.478000													41	229					4.32679e-17	4.92686e-17	1	0
MYH6	4624	broad.mit.edu	37	14	23874010	23874010	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr14:23874010C>A	uc001wjv.2	-	7	619	c.552G>T	c.(550-552)AAG>AAT	p.K184N	MYH6_uc010akp.1_Missense_Mutation_p.K184N	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	184	ATP.|Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TGTTCACAGTCTTCCCCGCCC	0.552000													7	58					1.06961e-07	1.15076e-07	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72152344	72152344	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr14:72152344A>T	uc001xms.2	+	10	3718	c.3370A>T	c.(3370-3372)AGG>TGG	p.R1124W	SIPA1L1_uc001xmt.2_Missense_Mutation_p.R1124W|SIPA1L1_uc001xmu.2_Missense_Mutation_p.R1124W|SIPA1L1_uc001xmv.2_Missense_Mutation_p.R1124W|SIPA1L1_uc010ttm.1_Missense_Mutation_p.R599W	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1124					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CCCACTAGAGAGGCGGTAAGT	0.507000													7	33					0	0	0	0
FMN1	342184	broad.mit.edu	37	15	33358886	33358886	+	Silent	SNP	T	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:33358886T>A	uc001zhf.3	-	1	1200	c.1200A>T	c.(1198-1200)ACA>ACT	p.T400T	FMN1_uc001zhg.2_Silent_p.T400T	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CCTCCAGGGCTGTCTCTGGCG	0.577000													16	58					0	0	0	0
C15orf55	256646	broad.mit.edu	37	15	34648621	34648621	+	Silent	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:34648621A>G	uc001zif.2	+	7	2483	c.2328A>G	c.(2326-2328)CTA>CTG	p.L776L	C15orf55_uc010ucc.1_Silent_p.L804L|C15orf55_uc010ucd.1_Silent_p.L794L	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	776						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GAGAAACCCTAGTACCTGGGG	0.537000			T	BRD3|BRD4	lethal midline carcinoma								15	81					0	0	0	0
THBS1	7057	broad.mit.edu	37	15	39884784	39884784	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:39884784G>A	uc001zkh.2	+	17	2727	c.2548G>A	c.(2548-2550)GAC>AAC	p.D850N	THBS1_uc010bbi.2_Missense_Mutation_p.D322N	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	850	TSP type-3 6.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CTCTGACTCAGACCGCATTGG	0.448000													5	14					0	0	0	0
THBS1	7057	broad.mit.edu	37	15	39884823	39884823	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:39884823G>A	uc001zkh.2	+	17	2766	c.2587G>A	c.(2587-2589)GAT>AAT	p.D863N	THBS1_uc010bbi.2_Missense_Mutation_p.D335N	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	863	TSP type-3 6.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TCAGGATATTGATGAAGATGG	0.468000													7	19					0	0	0	0
LDHAL6B	92483	broad.mit.edu	37	15	59499449	59499449	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:59499449G>A	uc002agb.2	+	1	408	c.310G>A	c.(310-312)GAA>AAA	p.E104K	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	104	NAD (By similarity).				glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	GGATCTTGATGAAGACAAACT	0.438000													18	122					0	0	0	0
MORF4L1	10933	broad.mit.edu	37	15	79172896	79172896	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:79172896A>G	uc002bel.2	+	3	318	c.130A>G	c.(130-132)ATA>GTA	p.I44V	MORF4L1_uc010bli.1_Missense_Mutation_p.I44V|MORF4L1_uc010blj.1_Missense_Mutation_p.I44V|MORF4L1_uc002bem.2_Missense_Mutation_p.I44V|MORF4L1_uc010une.1_5'UTR	NM_206839	NP_996670	Q9UBU8	MO4L1_HUMAN	MORF-related gene 15 isoform 2	44	Interaction with MYST1.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding				0						GAAATACTTCATACATTACAG	0.289000													10	30					0	0	0	0
DET1	55070	broad.mit.edu	37	15	89074302	89074302	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:89074302T>C	uc002bmr.2	-	2	787	c.635A>G	c.(634-636)GAC>GGC	p.D212G	DET1_uc002bmp.3_RNA|DET1_uc010bnk.2_RNA|DET1_uc002bmq.2_Missense_Mutation_p.D223G	NM_001144074	NP_001137546	Q7L5Y6	DET1_HUMAN	de-etiolated 1 isoform 2	212						nucleus				lung(1)|pancreas(1)	2	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			GACCACCTTGTCACACTTGAA	0.502000													13	53					0	0	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652000													3	18					0	0	0	0
KIAA0430	9665	broad.mit.edu	37	16	15694394	15694394	+	Silent	SNP	G	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr16:15694394G>C	uc002ddr.2	-	25	4897	c.4704C>G	c.(4702-4704)CTC>CTG	p.L1568L	KIAA0430_uc002ddq.2_Silent_p.L1402L|KIAA0430_uc010uzv.1_Silent_p.L1564L|KIAA0430_uc010uzw.1_Silent_p.L1567L	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	1567						peroxisome	nucleotide binding|RNA binding				0						GGGAGAGACTGAGTGAACTCA	0.552000													22	74					0	0	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77397755	77397755	+	Missense_Mutation	SNP	T	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr16:77397755T>G	uc002ffc.3	-	6	1419	c.1000A>C	c.(1000-1002)ATT>CTT	p.I334L	ADAMTS18_uc010chc.1_5'UTR|ADAMTS18_uc002ffe.1_Missense_Mutation_p.I30L|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	334	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TCACTTCCAATAGTCCCATCT	0.368000													8	41					0	0	0	0
RNMTL1	55178	broad.mit.edu	37	17	691248	691248	+	Silent	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:691248G>A	uc002frw.2	+	3	709	c.603G>A	c.(601-603)AAG>AAA	p.K201K		NM_018146	NP_060616	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	201					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		CATATCCAAAGACTCAGCTTC	0.483000													14	187					0	0	0	0
MNT	4335	broad.mit.edu	37	17	2298243	2298243	+	Silent	SNP	T	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:2298243T>G	uc002fur.2	-	2	831	c.579A>C	c.(577-579)CCA>CCC	p.P193P		NM_020310	NP_064706	Q99583	MNT_HUMAN	MAX binding protein	193					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			skin(1)	1				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		CCAGCGTGGGTGGGGGCGGCT	0.672000													4	13					0	0	0	0
NEURL4	84461	broad.mit.edu	37	17	7230951	7230951	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:7230951C>A	uc002gga.1	-	2	542	c.535G>T	c.(535-537)GGT>TGT	p.G179C	NEURL4_uc002ggb.1_Missense_Mutation_p.G179C|NEURL4_uc002ggc.1_5'Flank	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	179	NHR 1.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCAGCCACACCGCAATCCCGC	0.652000													32	43					2.20262e-25	2.56424e-25	1	0
TP53	7157	broad.mit.edu	37	17	7577547	7577547	+	Missense_Mutation	SNP	C	A	A	rs121912656		TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:7577547C>A	uc002gim.2	-	7	928	c.734G>T	c.(733-735)GGC>GTC	p.G245V	TP53_uc002gig.1_Missense_Mutation_p.G245V|TP53_uc002gih.2_Missense_Mutation_p.G245V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113V|TP53_uc010cng.1_Missense_Mutation_p.G113V|TP53_uc002gii.1_Missense_Mutation_p.G113V|TP53_uc010cnh.1_Missense_Mutation_p.G245V|TP53_uc010cni.1_Missense_Mutation_p.G245V|TP53_uc002gij.2_Missense_Mutation_p.G245V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152V|TP53_uc002gio.2_Missense_Mutation_p.G113V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245del(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.S241_G245delSCMGG(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			40	42					1.62957e-23	1.88306e-23	1	0
WRAP53	55135	broad.mit.edu	37	17	7592167	7592167	+	Silent	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:7592167A>G	uc010vuh.1	+	2	356	c.201A>G	c.(199-201)CTA>CTG	p.L67L	WRAP53_uc010vui.1_Silent_p.L67L|WRAP53_uc002gip.2_Silent_p.L67L|WRAP53_uc002gir.2_Silent_p.L67L|WRAP53_uc002giq.2_RNA|WRAP53_uc010cnl.2_Silent_p.L67L|TP53_uc010cnh.1_5'Flank|TP53_uc010cni.1_5'Flank|TP53_uc002gim.2_5'Flank|TP53_uc002gij.2_5'Flank|TP53_uc002gin.2_5'Flank|TP53_uc002gio.2_5'Flank|TP53_uc010vug.1_5'Flank|TP53_uc010cnk.1_5'Flank	NM_001143990	NP_001137462	Q9BUR4	WAP53_HUMAN	WD repeat domain 79 isoform 2	67					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding				0						CCCAGGAGCTACGGGAGGGGG	0.577000													29	90					0	0	0	0
PER1	5187	broad.mit.edu	37	17	8047060	8047060	+	Missense_Mutation	SNP	T	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:8047060T>G	uc002gkd.2	-	19	2834	c.2596A>C	c.(2596-2598)ACC>CCC	p.T866P	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_Intron	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	866	Pro-rich.				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						GGCCAGGGGGTGGAGGGTGGC	0.667000			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					4	24					0	0	0	0
MYH8	4626	broad.mit.edu	37	17	10293886	10293886	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:10293886C>G	uc002gmm.2	-	40	5794	c.5699G>C	c.(5698-5700)CGC>CCC	p.R1900P	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1900	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CTGGAGTTTGCGGAATTTAGA	0.453000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				19	143					0	0	0	0
FLII	2314	broad.mit.edu	37	17	18156743	18156743	+	Silent	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:18156743C>T	uc002gsr.1	-	9	936	c.885G>A	c.(883-885)AAG>AAA	p.K295K	FLII_uc002gsq.1_Silent_p.K167K|FLII_uc010cpy.1_Silent_p.K284K|FLII_uc010vxn.1_Silent_p.K264K|FLII_uc010vxo.1_Silent_p.K241K|FLII_uc002gss.1_Silent_p.K295K	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	295	Interaction with LRRFIP1 and LRRFIP2.|LRR 13.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					GGTACAGCTTCTTCAGCTTGC	0.587000													29	61					0	0	0	0
C17orf79	55352	broad.mit.edu	37	17	30179963	30179963	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:30179963C>G	uc002hgp.2	-	3	361	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	C17orf79_uc010css.2_RNA	NM_018405	NP_060875	Q9NQ92	COPR5_HUMAN	chromosome 17 open reading frame 79	85					histone H4-R3 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding				0		all_cancers(10;4.54e-07)|all_hematologic(16;0.0216)|Acute lymphoblastic leukemia(14;0.0255)|Myeloproliferative disorder(56;0.0393)|Ovarian(249;0.1)				TCAGAGTCCTCCTCATCCATG	0.522000													26	243					0	0	0	0
CCL15	6359	broad.mit.edu	37	17	34325338	34325338	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:34325338C>T	uc010wcu.1	-	3	795	c.226G>A	c.(226-228)GAG>AAG	p.E76K	CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA	NM_032965	NP_116741	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15 precursor	76					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTGGAGCACTCGCTGCTCGTT	0.522000													3	41					0	0	0	0
THRA	7067	broad.mit.edu	37	17	38240101	38240101	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:38240101G>A	uc002htw.2	+	5	719	c.236G>A	c.(235-237)CGC>CAC	p.R79H	THRA_uc010cwp.1_Missense_Mutation_p.R79H|THRA_uc002htv.2_Missense_Mutation_p.R79H|THRA_uc002htx.2_Missense_Mutation_p.R79H	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	79	Nuclear receptor.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	TTCTTTCGCCGCACAATCCAG	0.547000													4	105					0	0	0	0
LOC653653	653653	broad.mit.edu	37	17	58179845	58179845	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:58179845C>T	uc010wot.1	-	1	436	c.320G>A	c.(319-321)AGA>AAA	p.R107K		NM_003916	NP_003907			adaptor-related protein complex 1 sigma 2												0						ACTAGCATATCTTTTGTAAAC	0.368000													20	154					0	0	0	0
ABCA10	10349	broad.mit.edu	37	17	67189687	67189687	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr17:67189687C>A	uc010dfa.1	-	15	2467	c.1588G>T	c.(1588-1590)GGT>TGT	p.G530C	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.G131C	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	530	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TTCTGCCCACCACTTAATTTT	0.299000													7	13					0.000274275	0.000287161	1	0
SETBP1	26040	broad.mit.edu	37	18	42530201	42530201	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr18:42530201C>G	uc010dni.2	+	4	1192	c.896C>G	c.(895-897)CCA>CGA	p.P299R		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	299						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CACAGCTCACCAGCCCCACCC	0.572000									Schinzel-Giedion_syndrome				12	59					0	0	0	0
MATK	4145	broad.mit.edu	37	19	3779783	3779783	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:3779783C>T	uc002lyt.2	-	9	1155	c.755G>A	c.(754-756)GGT>GAT	p.G252D	MATK_uc002lyv.2_Missense_Mutation_p.G253D|MATK_uc002lyu.2_Missense_Mutation_p.G211D|MATK_uc010dtq.2_Missense_Mutation_p.G252D	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	252	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGTACTCACCCTGCAGGAC	0.627000													8	64					0	0	0	0
MAP2K2	5605	broad.mit.edu	37	19	4110577	4110577	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:4110577G>A	uc002lzk.2	-	3	634	c.380C>T	c.(379-381)TCG>TTG	p.S127L		NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	127	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GATGTACGGCGAGTTGCATTC	0.612000									Cardiofaciocutaneous_syndrome				8	48					0	0	0	0
ZNF441	126068	broad.mit.edu	37	19	11888528	11888528	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:11888528A>G	uc010dyj.2	+	2	300	c.106A>G	c.(106-108)ACC>GCC	p.T36A	ZNF441_uc002msn.3_5'UTR	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	36	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GATGCAGGAAACCATCAGAAA	0.423000													10	45					0	0	0	0
ABHD8	79575	broad.mit.edu	37	19	17411962	17411962	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:17411962T>C	uc002ngb.3	-	2	704	c.464A>G	c.(463-465)AAG>AGG	p.K155R		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	155							hydrolase activity				0						GATGGTCCTCTTGGGGCGCCT	0.473000													13	45					0	0	0	0
ZNF493	284443	broad.mit.edu	37	19	21606158	21606158	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:21606158A>T	uc002npx.2	+	2	593	c.313A>T	c.(313-315)ACT>TCT	p.T105S	ZNF493_uc002npw.2_Missense_Mutation_p.T233S|ZNF493_uc002npy.2_Missense_Mutation_p.T105S	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAGAGTTCATACTGGAGAGAA	0.368000													17	47					0	0	0	0
ZNF99	7652	broad.mit.edu	37	19	22939994	22939994	+	Silent	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:22939994A>G	uc010xrh.1	-	6	2337	c.2337T>C	c.(2335-2337)TGT>TGC	p.C779C		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAGCTTTGCCACATTCTTCAC	0.373000													8	65					0	0	0	0
CD22	933	broad.mit.edu	37	19	35832025	35832025	+	Silent	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:35832025C>T	uc010edt.2	+	7	1568	c.1491C>T	c.(1489-1491)GTC>GTT	p.V497V	CD22_uc010xst.1_Silent_p.V325V|CD22_uc010edu.2_Silent_p.V409V|CD22_uc010edv.2_Silent_p.V497V|CD22_uc002nzb.3_Silent_p.V320V|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	497	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CCTCCCCTGTCGCCCTGAATG	0.627000													36	64					0	0	0	0
NLRP8	126205	broad.mit.edu	37	19	56473581	56473581	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:56473581C>G	uc002qmh.2	+	4	2262	c.2191C>G	c.(2191-2193)CAG>GAG	p.Q731E	NLRP8_uc010etg.2_Missense_Mutation_p.Q731E	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	731						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGGCACCCTCAGTGCAAACT	0.478000													17	68					0	0	0	0
ZIM3	114026	broad.mit.edu	37	19	57646638	57646638	+	Missense_Mutation	SNP	A	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:57646638A>C	uc002qnz.1	-	5	1453	c.1067T>G	c.(1066-1068)ATT>AGT	p.I356S		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	356	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCAGTGTGAATTTTCTCATG	0.388000													21	133					0	0	0	0
SLC1A4	6509	broad.mit.edu	37	2	65245229	65245229	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:65245229G>A	uc010yqa.1	+	6	1381	c.1059G>A	c.(1057-1059)ATG>ATA	p.M353I	SLC1A4_uc010ypy.1_Missense_Mutation_p.M133I|SLC1A4_uc010ypz.1_Missense_Mutation_p.M55I|SLC1A4_uc010fcv.2_Missense_Mutation_p.M353I|SLC1A4_uc002sdh.2_Missense_Mutation_p.M133I	NM_003038	NP_003029	P43007	SATT_HUMAN	solute carrier family 1, member 4 isoform 1	353					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(1)	1					L-Alanine(DB00160)	CCTCTATGATGAAGTGCATTG	0.517000													36	88					0	0	0	0
AFF3	3899	broad.mit.edu	37	2	100210748	100210748	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:100210748C>A	uc002tag.2	-	14	1611	c.1375G>T	c.(1375-1377)GAA>TAA	p.E459*	AFF3_uc002taf.2_Nonsense_Mutation_p.E484*|AFF3_uc010fiq.1_Nonsense_Mutation_p.E459*|AFF3_uc010yvr.1_Nonsense_Mutation_p.E612*|AFF3_uc002tah.1_Nonsense_Mutation_p.E484*	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	459					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GATGCCGGTTCAGCCTGAAAG	0.433000													33	186					8.53417e-09	9.31001e-09	1	0
ACMSD	130013	broad.mit.edu	37	2	135621074	135621074	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:135621074A>G	uc002ttz.2	+	5	426	c.359A>G	c.(358-360)CAG>CGG	p.Q120R	ACMSD_uc002tua.2_Missense_Mutation_p.Q62R	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	120					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		TTGCCCATGCAGGCCCCTGAG	0.587000													3	73					0	0	0	0
SCN1A	6323	broad.mit.edu	37	2	166897962	166897962	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:166897962G>T	uc010zcz.1	-	13	2179	c.2161C>A	c.(2161-2163)CAG>AAG	p.Q721K	SCN1A_uc002udo.3_Missense_Mutation_p.Q601K|SCN1A_uc010fpk.2_Missense_Mutation_p.Q573K	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	732						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGGCATTTCTGCCTGGATTCT	0.323000													32	56					1.36615e-20	1.56705e-20	1	0
TTN	7273	broad.mit.edu	37	2	179582358	179582358	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:179582358C>T	uc010zfg.1	-	84	21735	c.21511G>A	c.(21511-21513)GCA>ACA	p.A7171T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A3832T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8098							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAGAGTTGCTACATTATGA	0.428000													4	21					0	0	0	0
SPAG16	79582	broad.mit.edu	37	2	215274872	215274872	+	Silent	SNP	T	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:215274872T>C	uc002veq.2	+	16	1821	c.1729T>C	c.(1729-1731)TTA>CTA	p.L577L	SPAG16_uc002ver.2_Silent_p.L523L|SPAG16_uc010zjk.1_Silent_p.L483L|VWC2L_uc002vet.2_5'Flank|VWC2L_uc010zjl.1_5'Flank	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	577	WD 6.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGGTCGAGTTTTAGCTCAGGC	0.408000													21	47					0	0	0	0
DOCK10	55619	broad.mit.edu	37	2	225652094	225652094	+	Silent	SNP	T	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:225652094T>C	uc010fwz.1	-	49	5678	c.5439A>G	c.(5437-5439)CTA>CTG	p.L1813L	DOCK10_uc002vob.2_Silent_p.L1807L|DOCK10_uc002voa.2_Silent_p.L469L|DOCK10_uc002voc.2_Silent_p.L634L	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1813	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CACACATGTATAGCTGCTCCA	0.428000													65	174					0	0	0	0
TRIP12	9320	broad.mit.edu	37	2	230663654	230663654	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:230663654G>A	uc002vpw.1	-	22	3303	c.3194C>T	c.(3193-3195)GCA>GTA	p.A1065V	TRIP12_uc002vpx.1_Missense_Mutation_p.A1113V|TRIP12_uc002vpy.1_Missense_Mutation_p.A795V|TRIP12_uc010zlz.1_RNA	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1065					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CGCAGTCCGTGCTGGCTCAAT	0.478000													19	52					0	0	0	0
TMC2	117532	broad.mit.edu	37	20	2542577	2542577	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:2542577C>T	uc002wgf.1	+	4	490	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	TMC2_uc002wgg.1_Nonsense_Mutation_p.Q143*|TMC2_uc010zpw.1_5'UTR|TMC2_uc010zpx.1_5'UTR	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	159	Arg/Asp/Glu/Lys-rich (highly charged).|Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GATCCTGGAGCAGGTGGAAGA	0.627000													13	70					0	0	0	0
ATRN	8455	broad.mit.edu	37	20	3541513	3541513	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:3541513C>G	uc002wim.2	+	8	1498	c.1408C>G	c.(1408-1410)CTC>GTC	p.L470V	ATRN_uc002wil.2_Missense_Mutation_p.L470V	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	470	Extracellular (Potential).|Kelch 3.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						TCACTGCCCTCTCTATGGATA	0.418000													5	66					0	0	0	0
PLCB1	23236	broad.mit.edu	37	20	8352093	8352093	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:8352093C>G	uc002wnb.2	+	3	245	c.242C>G	c.(241-243)CCC>CGC	p.P81R	PLCB1_uc010zrb.1_5'UTR|PLCB1_uc010gbv.1_Missense_Mutation_p.P81R|PLCB1_uc002wmz.1_Missense_Mutation_p.P81R|PLCB1_uc002wna.2_Missense_Mutation_p.P81R	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	81					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GCCAAAGCTCCCAAGGTAGGA	0.458000													9	51					0	0	0	0
KIF16B	55614	broad.mit.edu	37	20	16359581	16359581	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:16359581G>C	uc002wpg.1	-	19	3224	c.3066C>G	c.(3064-3066)CAC>CAG	p.H1022Q	KIF16B_uc002wpe.1_Missense_Mutation_p.H404Q|KIF16B_uc002wpf.1_Missense_Mutation_p.H404Q|KIF16B_uc010gch.1_Missense_Mutation_p.H1022Q|KIF16B_uc010gci.1_Missense_Mutation_p.H1022Q|KIF16B_uc010gcj.1_Missense_Mutation_p.H1033Q	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	1022	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity	p.H1022Q(1)		skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CCAGGGTGGAGTGCCTCTGCA	0.597000													6	106					0	0	0	0
FRG1B	284802	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	C	C	rs145412486	by1000genomes	TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:29628236G>C	uc010ztl.1	+	3	180	c.148G>C	c.(148-150)GCT>CCT	p.A50P	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.A2P					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GGGGAAAATGGCTTTGTTGGC	0.333000													3	105					0	0	0	0
RBM39	9584	broad.mit.edu	37	20	34317447	34317447	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr20:34317447G>A	uc002xeb.2	-	5	643	c.299C>T	c.(298-300)TCC>TTC	p.S100F	RBM39_uc002xdz.2_Missense_Mutation_p.S76F|RBM39_uc002xea.2_5'UTR|RBM39_uc010gfn.2_5'UTR|RBM39_uc010zvm.1_Intron|RBM39_uc002xeg.2_Intron|RBM39_uc002xec.2_Missense_Mutation_p.S100F|RBM39_uc002xed.2_5'UTR|RBM39_uc002xee.2_5'UTR|RBM39_uc002xef.2_5'UTR|RBM39_uc010zvn.1_5'UTR	NM_184234	NP_909122	Q14498	RBM39_HUMAN	RNA binding motif protein 39 isoform a	100					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					TTTTGGTCCGGAGCTAAAAAG	0.373000													4	53					0	0	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28216933	28216933	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr21:28216933G>A	uc002ymf.2	-	1	796	c.341C>T	c.(340-342)CCG>CTG	p.P114L		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	114					integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		TTCCGGAAGCGGCGTCTCGGA	0.677000											OREG0026151	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	16					0	0	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066855	46066855	+	Silent	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr21:46066855C>T	uc002zfr.3	+	1	525	c.480C>T	c.(478-480)ACC>ACT	p.T160T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	160	25 X 5 AA repeats of C-C-X(3).|15.					keratin filament				ovary(1)	1						GTGTGTCCACCTGCTCTGAGG	0.383000													86	157					0	0	0	0
EFCAB6	64800	broad.mit.edu	37	22	43926760	43926760	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr22:43926760G>A	uc003bdy.1	-	31	4533	c.4318C>T	c.(4318-4320)CGG>TGG	p.R1440W	EFCAB6_uc003bdz.1_Missense_Mutation_p.R1288W|EFCAB6_uc010gzi.1_Missense_Mutation_p.R1288W	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1440	Interaction with AR.|EF-hand 16.|Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				AACGTGCGCCGCATTGGCCTC	0.562000													4	108					0	0	0	0
SAPS2	9701	broad.mit.edu	37	22	50862016	50862016	+	Silent	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr22:50862016C>T	uc003blb.1	+	11	1520	c.1098C>T	c.(1096-1098)TGC>TGT	p.C366C	SAPS2_uc003bky.1_Silent_p.C366C|SAPS2_uc003bkz.1_Silent_p.C366C|SAPS2_uc003blc.2_Silent_p.C366C|SAPS2_uc003bla.1_Silent_p.C367C|uc011arw.1_5'Flank	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	366						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		AGGAGCTCTGCCGGCTCAACA	0.627000													6	49					0	0	0	0
HACL1	26061	broad.mit.edu	37	3	15609397	15609397	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:15609397C>T	uc003caf.2	-	14	1523	c.1363G>A	c.(1363-1365)GAC>AAC	p.D455N	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Missense_Mutation_p.D428N|HACL1_uc011avt.1_Missense_Mutation_p.D395N|HACL1_uc003cag.2_Missense_Mutation_p.D99N|HACL1_uc011avu.1_Missense_Mutation_p.D373N|HACL1_uc010hep.2_Missense_Mutation_p.D214N	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	455	Thiamine pyrophosphate binding.	Magnesium (By similarity).			fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						AATGCACTGTCTCCTTCCACA	0.443000													19	210					0	0	0	0
CELSR3	1951	broad.mit.edu	37	3	48691215	48691215	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:48691215G>A	uc003cul.2	-	9	5566	c.5285C>T	c.(5284-5286)GCC>GTC	p.A1762V	CELSR3_uc003cuf.1_Missense_Mutation_p.A1832V|CELSR3_uc010hkg.2_5'Flank	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1762	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTGGGGATGGGCCATAGCTGA	0.577000													4	71					0	0	0	0
NCKIPSD	51517	broad.mit.edu	37	3	48719836	48719836	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:48719836C>T	uc003cun.2	-	3	525	c.431G>A	c.(430-432)CGG>CAG	p.R144Q	NCKIPSD_uc003cum.2_Missense_Mutation_p.R144Q|NCKIPSD_uc010hkh.1_Missense_Mutation_p.R144Q	NM_016453	NP_057537	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain isoform	144					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTGTGCTGCCGCTCGAACCC	0.597000													14	133					0	0	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54913049	54913049	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:54913049G>C	uc003dhf.2	+	19	1763	c.1715G>C	c.(1714-1716)AGA>ACA	p.R572T	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.R478T|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Missense_Mutation_p.R306T|uc003dhk.1_Intron	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	572	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTTTAGTTGAGAAATGCTATG	0.408000													3	26					0	0	0	0
CADM2	253559	broad.mit.edu	37	3	85961658	85961658	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:85961658C>G	uc003dqj.2	+	5	1264	c.638C>G	c.(637-639)ACC>AGC	p.T213S	CADM2_uc003dqk.2_Missense_Mutation_p.T222S|CADM2_uc003dql.2_Missense_Mutation_p.T215S	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	213	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CTCAATGCCACCCCTCAGGTA	0.488000													13	30					0	0	0	0
KALRN	8997	broad.mit.edu	37	3	124415027	124415027	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:124415027G>C	uc003ehg.2	+	54	7751	c.7624G>C	c.(7624-7626)GAC>CAC	p.D2542H	KALRN_uc003ehk.2_Missense_Mutation_p.D845H	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2541	Ig-like C2-type.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GATGCCCCAAGACAGTGGGAT	0.463000													23	154					0	0	0	0
GATA2	2624	broad.mit.edu	37	3	128199926	128199926	+	Missense_Mutation	SNP	T	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:128199926T>G	uc003ekm.3	-	7	1814	c.1379A>C	c.(1378-1380)CAC>CCC	p.H460P	GATA2_uc003ekn.3_Missense_Mutation_p.H446P|GATA2_uc003eko.2_Missense_Mutation_p.H460P	NM_001145661	NP_001139133	P23769	GATA2_HUMAN	GATA binding protein 2 isoform 1	460					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(13)|lung(1)|skin(1)	15				GBM - Glioblastoma multiforme(114;0.173)		GGAGGAGGGGTGGATGGGCGT	0.687000			Mis		AML(CML blast transformation)								8	56					0	0	0	0
GK5	256356	broad.mit.edu	37	3	141884493	141884493	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:141884493G>A	uc003euq.1	-	16	1692	c.1561C>T	c.(1561-1563)CGC>TGC	p.R521C	GK5_uc003eup.1_Missense_Mutation_p.R242C|GK5_uc010hus.1_RNA	NM_001039547	NP_001034636	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	521					glycerol metabolic process		ATP binding|glycerol kinase activity				0						TTCATGGAGCGTTTCACTGCT	0.393000													19	146					0	0	0	0
KCNAB1	7881	broad.mit.edu	37	3	155838565	155838565	+	Silent	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:155838565C>G	uc003far.2	+	1	229	c.165C>G	c.(163-165)CTC>CTG	p.L55L	KCNAB1_uc011bon.1_Silent_p.L55L	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	55						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AAAGCCAGCTCAGGGCGCGTC	0.557000													10	61					0	0	0	0
SPATA16	83893	broad.mit.edu	37	3	172643242	172643242	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:172643242C>A	uc003fin.3	-	7	1280	c.1122G>T	c.(1120-1122)TGG>TGT	p.W374C		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	374					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GAAAAGATGACCAGTCAACTG	0.368000													16	68					5.35267e-07	5.71929e-07	1	0
ZNF721	170960	broad.mit.edu	37	4	436363	436363	+	Silent	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:436363C>T	uc003gag.2	-	3	2584	c.1893G>A	c.(1891-1893)CAG>CAA	p.Q631Q	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Silent_p.Q663Q|ZNF721_uc010ibe.2_Silent_p.Q619Q	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	631						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AAATTTTCTTCTGTTGATTCA	0.403000													29	285					0	0	0	0
TADA2B	93624	broad.mit.edu	37	4	7056454	7056454	+	Silent	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:7056454G>A	uc003gjw.3	+	2	1087	c.936G>A	c.(934-936)CGG>CGA	p.R312R	TADA2B_uc010idi.2_Silent_p.R237R	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0						AGGCAGCGCGGCATAAACGGG	0.557000													3	44					0	0	0	0
SLIT2	9353	broad.mit.edu	37	4	20482374	20482374	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:20482374A>T	uc003gpr.1	+	6	707	c.503A>T	c.(502-504)GAT>GTT	p.D168V	SLIT2_uc003gps.1_Missense_Mutation_p.D168V	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	168	LRR 5.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TGTATTGAAGATGGGGCATTC	0.458000													15	70					0	0	0	0
BEND4	389206	broad.mit.edu	37	4	42145927	42145927	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:42145927G>T	uc003gwn.2	-	3	1152	c.572C>A	c.(571-573)TCC>TAC	p.S191Y	BEND4_uc003gwm.2_Missense_Mutation_p.S191Y|BEND4_uc011byy.1_Missense_Mutation_p.S191Y	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	191											0						AGAATGGTTGGAGTCCAGGAG	0.468000													3	17					0.004672	0.00485888	1	0
WDFY3	23001	broad.mit.edu	37	4	85748035	85748035	+	Silent	SNP	T	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:85748035T>A	uc003hpd.2	-	10	1464	c.1056A>T	c.(1054-1056)CCA>CCT	p.P352P	WDFY3_uc003hpf.2_Silent_p.P352P	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	352						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TAATACCAGCTGGTTTTAGTT	0.438000													7	50					0	0	0	0
DKK2	27123	broad.mit.edu	37	4	107847051	107847051	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:107847051G>A	uc003hyi.2	-	2	983	c.278C>T	c.(277-279)CCC>CTC	p.P93L	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Missense_Mutation_p.P93L	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	93	DKK-type Cys-1.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		TCCTTGGTGGGGACTGTGGCA	0.512000													3	88					0	0	0	0
NDST4	64579	broad.mit.edu	37	4	115773929	115773929	+	Missense_Mutation	SNP	T	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:115773929T>G	uc003ibu.2	-	8	2447	c.1768A>C	c.(1768-1770)ACT>CCT	p.T590P	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	590	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TGGTCACAAGTTTTCTCTCTG	0.348000													9	28					0	0	0	0
USP53	54532	broad.mit.edu	37	4	120213687	120213687	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:120213687C>G	uc003ics.3	+	18	3609	c.2543C>G	c.(2542-2544)TCT>TGT	p.S848C	USP53_uc003icr.3_Missense_Mutation_p.S848C|USP53_uc003icu.3_Missense_Mutation_p.S471C	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	848					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						GTTGATAACTCTGCTTCTGGG	0.393000													6	43					0	0	0	0
CCNA2	890	broad.mit.edu	37	4	122742139	122742139	+	Missense_Mutation	SNP	T	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr4:122742139T>G	uc003iec.3	-	3	870	c.565A>C	c.(565-567)ATG>CTG	p.M189L		NM_001237	NP_001228	P20248	CCNA2_HUMAN	cyclin A	189					cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			ovary(1)	1						TTTACCTCCATTTCCCTAAGG	0.313000													9	77					0	0	0	0
MYO10	4651	broad.mit.edu	37	5	16761646	16761646	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:16761646C>T	uc003jft.3	-	17	2134	c.1666G>A	c.(1666-1668)GAT>AAT	p.D556N	MYO10_uc010itx.2_Missense_Mutation_p.D179N	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	556	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CCTCGGACATCATATTGCACC	0.383000													18	107					0	0	0	0
EGFLAM	133584	broad.mit.edu	37	5	38464020	38464020	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:38464020G>C	uc003jlc.1	+	23	3310	c.2986G>C	c.(2986-2988)GAT>CAT	p.D996H	EGFLAM_uc003jlb.1_Missense_Mutation_p.D988H|EGFLAM_uc003jle.1_Missense_Mutation_p.D754H|EGFLAM_uc003jlf.1_Missense_Mutation_p.D354H|EGFLAM_uc003jlg.1_Missense_Mutation_p.D131H|EGFLAM_uc003jlh.1_Missense_Mutation_p.D78H	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	996	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					CCTGTCCACCGATTACCACAT	0.512000													11	54					0	0	0	0
FBXO4	26272	broad.mit.edu	37	5	41929884	41929884	+	Silent	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:41929884C>T	uc003jmq.2	+	3	567	c.511C>T	c.(511-513)CTG>TTG	p.L171L	FBXO4_uc003jmp.2_Silent_p.L171L|FBXO4_uc003jmr.2_Silent_p.L171L	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	171					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				TTTACACTCCCTGATCATTCA	0.403000													15	100					0	0	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715528	99715528	+	RNA	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:99715528C>T	uc011cuw.1	-	4		c.382G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AGCGGACAGTCGAAGCCCTTC	0.607000													3	6					0	0	0	0
DDX46	9879	broad.mit.edu	37	5	134121257	134121257	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:134121257G>C	uc003kzw.2	+	11	1613	c.1445G>C	c.(1444-1446)GGA>GCA	p.G482A	DDX46_uc003kzv.1_RNA	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	482	Helicase ATP-binding.				mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTTACGGAGGAACAGGAATC	0.363000													8	68					0	0	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140798773	140798773	+	Silent	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:140798773G>A	uc003lkn.1	+	1	1492	c.1347G>A	c.(1345-1347)GCG>GCA	p.A449A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Silent_p.A449A|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	449	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACAACGCGCCGGTTTTCG	0.572000													4	49					0	0	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148715178	148715178	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:148715178A>T	uc003lqh.2	+	18	2307	c.2176A>T	c.(2176-2178)AAC>TAC	p.N726Y	AFAP1L1_uc010jgy.2_Intron|AFAP1L1_uc003lqi.1_Missense_Mutation_p.N341Y	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	726							protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAAACCCCAGAACAGCGTTCC	0.488000													5	93					0	0	0	0
ATP10B	23120	broad.mit.edu	37	5	160063305	160063305	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr5:160063305A>T	uc003lym.1	-	11	1859	c.1012T>A	c.(1012-1014)TGG>AGG	p.W338R	ATP10B_uc003lyp.2_Missense_Mutation_p.W338R|ATP10B_uc011deg.1_Missense_Mutation_p.W382R|ATP10B_uc003lyn.2_5'Flank|ATP10B_uc003lyo.2_Missense_Mutation_p.W310R	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	338	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCCCATTCCAGATGCTGTGA	0.493000													3	58					0	0	0	0
NRSN1	140767	broad.mit.edu	37	6	24145830	24145830	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:24145830G>T	uc010jpq.1	+	4	481	c.244G>T	c.(244-246)GTG>TTG	p.V82L		NM_080723	NP_542454	Q8IZ57	NRSN1_HUMAN	neurensin 1	82	Helical; (Potential).				nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle					0						TGTTCTGGCAGTGGGCTTTCT	0.478000													14	149					4.36969e-10	4.80051e-10	1	0
HLA-A	3105	broad.mit.edu	37	6	29910693	29910693	+	Missense_Mutation	SNP	A	G	G	rs41559716		TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:29910693A>G	uc003nol.2	+	2	233	c.233A>G	c.(232-234)CAG>CGG	p.Q78R	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Missense_Mutation_p.Q78R|HLA-A_uc003noo.2_Missense_Mutation_p.Q78R|HLA-A_uc010jrr.2_Missense_Mutation_p.Q78R|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_Missense_Mutation_p.Q50R|HLA-A_uc011dmc.1_5'UTR|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	78	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TGGATAGAGCAGGAGGGGCCG	0.657000									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			4	26					0	0	0	0
SLC35B2	347734	broad.mit.edu	37	6	44222789	44222789	+	Missense_Mutation	SNP	A	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:44222789A>T	uc003oxd.2	-	4	1089	c.953T>A	c.(952-954)CTG>CAG	p.L318Q	SLC35B2_uc011dvt.1_Missense_Mutation_p.L221Q|SLC35B2_uc011dvu.1_Missense_Mutation_p.L185Q	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	318	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTGTTCTAGCAGTGAGCCCAC	0.557000													17	37					0	0	0	0
HCRTR2	3062	broad.mit.edu	37	6	55113547	55113547	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:55113547C>A	uc003pcl.2	+	2	649	c.334C>A	c.(334-336)CTG>ATG	p.L112M	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.L47M	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	112	Extracellular (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TCCAGCCACACTGGTCGTGGA	0.443000													18	168					0.000132079	0.000140165	1	0
MDN1	23195	broad.mit.edu	37	6	90425374	90425374	+	Silent	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:90425374G>A	uc003pnn.1	-	45	6974	c.6858C>T	c.(6856-6858)TTC>TTT	p.F2286F		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2286					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACAAATACCTGAAATTGGGAT	0.403000													10	113					0	0	0	0
FAM184A	79632	broad.mit.edu	37	6	119324126	119324126	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:119324126C>G	uc003pyj.2	-	9	2374	c.2026G>C	c.(2026-2028)GAT>CAT	p.D676H	FAM184A_uc003pyk.3_Missense_Mutation_p.D556H|FAM184A_uc003pyl.3_Missense_Mutation_p.D556H	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	676	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TTCTCTCGATCTTTCAACTGC	0.358000													11	89					0	0	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130370430	130370430	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:130370430C>T	uc003qbt.2	+	4	276	c.106C>T	c.(106-108)CGG>TGG	p.R36W	L3MBTL3_uc003qbu.2_Missense_Mutation_p.R36W	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	36					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		TTGCTAGTTTCGGGTAAATGA	0.368000													8	25					0	0	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597106	136597106	+	Silent	SNP	C	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:136597106C>G	uc003qgx.1	-	5	1810	c.1557G>C	c.(1555-1557)CTG>CTC	p.L519L	BCLAF1_uc003qgw.1_Silent_p.L346L|BCLAF1_uc003qgy.1_Silent_p.L517L|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.L517L	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	519					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTCGTGCATCCAGATTCTTGT	0.423000													12	310					0	0	0	0
GRM1	2911	broad.mit.edu	37	6	146480529	146480529	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr6:146480529C>T	uc010khw.1	+	3	1216	c.746C>T	c.(745-747)GCC>GTC	p.A249V	GRM1_uc010khu.1_Missense_Mutation_p.A249V|GRM1_uc010khv.1_Missense_Mutation_p.A249V|GRM1_uc003qll.2_Missense_Mutation_p.A249V|GRM1_uc011edz.1_Missense_Mutation_p.A249V|GRM1_uc011eea.1_Missense_Mutation_p.A249V	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	249	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GAGCTGGCTGCCCAGGAAGGC	0.507000													9	82					0	0	0	0
INTS1	26173	broad.mit.edu	37	7	1528988	1528988	+	Silent	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:1528988C>T	uc003skn.2	-	18	2411	c.2310G>A	c.(2308-2310)GTG>GTA	p.V770V	INTS1_uc003skp.1_Silent_p.V117V	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	770					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		ACTTGGTCATCACCATCTCCA	0.682000													4	17					0	0	0	0
CLIP2	7461	broad.mit.edu	37	7	73790521	73790521	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:73790521A>G	uc003uam.2	+	10	2117	c.1790A>G	c.(1789-1791)GAC>GGC	p.D597G	CLIP2_uc003uan.2_Missense_Mutation_p.D562G|CLIP2_uc003uao.2_5'UTR	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	597	Potential.					microtubule associated complex				skin(3)	3						GGCCTGAAGGACAAGGTTCAG	0.612000													5	21					0	0	0	0
CLIP2	7461	broad.mit.edu	37	7	73795176	73795176	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:73795176C>T	uc003uam.2	+	11	2789	c.2462C>T	c.(2461-2463)ACG>ATG	p.T821M	CLIP2_uc003uan.2_Missense_Mutation_p.T786M|CLIP2_uc003uao.2_Missense_Mutation_p.T215M	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	821	Potential.					microtubule associated complex				skin(3)	3						ACGATCAGGACGAAGGAAACT	0.602000													26	85					0	0	0	0
TRPV5	56302	broad.mit.edu	37	7	142625874	142625874	+	Missense_Mutation	SNP	T	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:142625874T>G	uc003wby.1	-	6	938	c.674A>C	c.(673-675)CAT>CCT	p.H225P	TRPV5_uc003wbz.2_Missense_Mutation_p.H225P	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	225	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GTGGTCCCCATGTCCATCGTA	0.567000													4	92					0	0	0	0
OR2F2	135948	broad.mit.edu	37	7	143632931	143632931	+	Silent	SNP	T	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:143632931T>G	uc011ktv.1	+	1	606	c.606T>G	c.(604-606)TCT>TCG	p.S202S		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					TCATGGTGTCTAGCATTGTTC	0.478000													15	56					0	0	0	0
POTEA	340441	broad.mit.edu	37	8	43147925	43147925	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr8:43147925A>G	uc003xpz.1	+	1	341	c.298A>G	c.(298-300)AGG>GGG	p.R100G	POTEA_uc003xqa.1_Missense_Mutation_p.R100G	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	100	ANK 1.									ovary(1)	1						CAAGAAGAAGAGGTAACCGGG	0.627000													3	56					0	0	0	0
ATP6V1C1	528	broad.mit.edu	37	8	104054601	104054601	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr8:104054601G>A	uc003ykz.3	+	3	411	c.166G>A	c.(166-168)GAT>AAT	p.D56N	ATP6V1C1_uc010mbz.2_5'UTR|ATP6V1C1_uc003yla.2_Missense_Mutation_p.D56N|ATP6V1C1_uc011lhl.1_Intron	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	56					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			TGGCTTGTCAGATGAACTGGC	0.363000													12	128					0	0	0	0
MCART1	92014	broad.mit.edu	37	9	37887716	37887716	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr9:37887716G>A	uc004aau.2	-	3	1576	c.832C>T	c.(832-834)CGG>TGG	p.R278W	MCART1_uc004aar.1_Intron|MCART1_uc004aaq.1_Intron|uc004aat.1_5'Flank|MCART1_uc004aav.2_Missense_Mutation_p.R278W	NM_033412	NP_219480	Q9H1U9	MCAR1_HUMAN	mitochondrial carrier triple repeat 1	278	Helical; Name=6; (Potential).|Solcar 3.				transport	integral to membrane|mitochondrial inner membrane				ovary(2)|breast(1)	3				GBM - Glioblastoma multiforme(29;0.00559)|Lung(182;0.0422)		ATGAGGGACCGATGGTAATTC	0.393000													10	48					0	0	0	0
GPR107	57720	broad.mit.edu	37	9	132887236	132887236	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr9:132887236A>G	uc004bze.2	+	17	1720	c.1493A>G	c.(1492-1494)TAC>TGC	p.Y498C	GPR107_uc004bzb.2_Missense_Mutation_p.Y261C|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.Y469C|GPR107_uc004bzd.2_Missense_Mutation_p.Y450C	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	498						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				AGACATTATTACGTCTTGGTA	0.308000													2	3					0	0	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071110	141071110	+	Silent	SNP	A	G	G			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr9:141071110A>G	uc004com.2	+	4	774	c.513A>G	c.(511-513)CCA>CCG	p.P171P	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TGCGCTTCCCAGGCCAGCTGA	0.597000													3	40					0	0	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83357104	83357104	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chrX:83357104G>A	uc004eej.1	-	18	1794	c.1717C>T	c.(1717-1719)CGA>TGA	p.R573*	RPS6KA6_uc011mqt.1_Nonsense_Mutation_p.R573*|RPS6KA6_uc011mqu.1_Nonsense_Mutation_p.R470*	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	573	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TTTTCTCCTCGAAGTTGTTTT	0.368000													15	7					0	0	0	0
KLHL4	56062	broad.mit.edu	37	X	86890582	86890582	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chrX:86890582C>T	uc004efb.2	+	9	1914	c.1732C>T	c.(1732-1734)CGT>TGT	p.R578C	KLHL4_uc004efa.2_Missense_Mutation_p.R578C	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	578	Kelch 4.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TATTGGTGGACGTGATGGAAG	0.398000													11	12					0	0	0	0
Unknown	0	broad.mit.edu	37	10	86577706	86577708	+	IGR	DEL	CAG	-	-			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr10:86577706_86577708delCAG								FAM190B (299430 upstream) : GRID1 (781604 downstream)																							gcccaggtgccagcagcagcagc	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	12	77054687	77054687	+	IGR	DEL	T	-	-	rs2369296	by1000genomes	TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr12:77054687delT								OSBPL8 (101098 upstream) : ZDHHC17 (103167 downstream)																							aaaaaaaaaataaataaaGGA	0.358													---	---	---							
C12orf12	196477	broad.mit.edu	37	12	91347586	91347587	+	In_Frame_Ins	INS	-	TTG	TTG	rs3832847		TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr12:91347586_91347587insTTG	uc001tbj.2	-	1	1367_1368	c.933_934insCAA	c.(931-936)insCAA	p.311_312insQ		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	311_312	Potential.|Glu-rich.									central_nervous_system(1)|pancreas(1)	2						tcgacctcttcctcctcatctt	0.064													---	---	---							
Unknown	0	broad.mit.edu	37	12	119145925	119145930	+	IGR	DEL	TGGTGA	-	-	rs140066713	by1000genomes	TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr12:119145925_119145930delTGGTGA								SUDS3 (290086 upstream) : SRRM4 (273466 downstream)																							gtgatggtggtggtgatggtgatggt	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	14	35982108	35982108	+	IGR	DEL	C	-	-			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr14:35982108delC								NFKBIA (108148 upstream) : INSM2 (21140 downstream)																							CACAGCCAGGCCCCCAGACCC	0.622													---	---	---							
Unknown	0	broad.mit.edu	37	15	22448191	22448191	+	IGR	DEL	C	-	-			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:22448191delC								OR4N3P (33806 upstream) : MIR1268 (65038 downstream)																							aaaaaaaaaaCACCAAAAAAC	0.114													---	---	---							
Unknown	0	broad.mit.edu	37	15	45902861	45902861	+	IGR	DEL	A	-	-			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr15:45902861delA								PLDN (953 upstream) : SQRDL (20485 downstream)																							Ctattttattaaaaaaaaaaa	0.338													---	---	---							
MYOM1	8736	broad.mit.edu	37	18	3086058	3086059	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr18:3086058_3086059insT	uc002klp.2	-	30	4562_4563	c.4228_4229insA	c.(4228-4230)ATAfs	p.I1410fs	MYOM1_uc002klq.2_Frame_Shift_Ins_p.I1314fs	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1410	Ig-like C2-type 4.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CAGGGTACATATACCATCCTTA	0.366													---	---	---							
Unknown	0	broad.mit.edu	37	19	22646691	22646698	+	IGR	DEL	TATGTGTC	-	-	rs111647491		TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr19:22646691_22646698delTATGTGTC								ZNF98 (41543 upstream) : ZNF492 (170428 downstream)																							tgtgtgtgtgtatgtgtctatgtgtgag	0.250													---	---	---							
Unknown	0	broad.mit.edu	37	2	89399574	89399574	+	RNA	DEL	G	-	-			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:89399574delG	uc010ytr.1	-	46		c.4871delC			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		CCCGACAAGTGATGGTGACTC	0.483													---	---	---							
Unknown	0	broad.mit.edu	37	2	90121911	90121911	+	RNA	DEL	C	-	-			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:90121911delC	uc010fhm.2	+	16		c.1780delC								Parts of antibodies, mostly variable regions.																		GAGTCACCATCACTTGTCGGG	0.478													---	---	---							
PLCL1	5334	broad.mit.edu	37	2	198953700	198953701	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr2:198953700_198953701delTT	uc010fsp.2	+	3	3125_3126	c.2834_2835delTT	c.(2833-2835)CTTfs	p.L945fs	PLCL1_uc002uuv.3_Frame_Shift_Del_p.L866fs	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	945					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TCAGTCTCACTTGTGATGAAAG	0.470													---	---	---							
Unknown	0	broad.mit.edu	37	3	14415403	14415404	+	IGR	DEL	TC	-	-			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:14415403_14415404delTC								LSM3 (175567 upstream) : SLC6A6 (28702 downstream)																							TCTCCTGCCTtctctctctctc	0.460													---	---	---							
PRKCD	5580	broad.mit.edu	37	3	53222779	53222780	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr3:53222779_53222780insT	uc003dgl.2	+	16	1812_1813	c.1459_1460insT	c.(1459-1461)ATCfs	p.I487fs	PRKCD_uc003dgm.2_Frame_Shift_Ins_p.I487fs	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	487	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		GGATGGCCACATCAAGATTGCC	0.564													---	---	---							
Unknown	0	broad.mit.edu	37	7	114368922	114368923	+	IGR	INS	-	T	T			TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr7:114368922_114368923insT								FOXP2 (37830 upstream) : MDFIC (193286 downstream)																							cttccttcctcttttttttttg	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	9	68380404	68380405	+	IGR	INS	-	G	G	rs144187147		TCGA-CR-6474-01A-11D-1870-08	TCGA-CR-6474-10A-01D-1870-08									Somatic	Phase_I	Capture				Illumina GAIIx	6b4369e1-cf03-4a40-9a66-fc67bfb946b3	11f422c3-46e6-47c6-9f85-5708ec25b154	g.chr9:68380404_68380405insG								FAM27B (586215 upstream) : MIR1299 (621834 downstream)																							CTCCTTTGCCAGGGGCTGGGCA	0.728													---	---	---							
