Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
SDF4	51150	broad.mit.edu	37	1	1163936	1163936	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:1163936C>G	uc001adh.3	-	2	567	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	SDF4_uc001adi.3_Missense_Mutation_p.E80Q|SDF4_uc009vjv.2_Intron|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	80					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		AGGAAGACCTCCTGGTGGAAG	0.617000													17	31					0	0	0	0
SDF4	51150	broad.mit.edu	37	1	1164020	1164020	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:1164020C>T	uc001adh.3	-	2	483	c.154G>A	c.(154-156)GAG>AAG	p.E52K	SDF4_uc001adi.3_Missense_Mutation_p.E52K|SDF4_uc009vjv.2_Intron|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	52					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		TCATTCTCCTCCCTGTTGGCT	0.627000													29	44					0	0	0	0
C1orf127	148345	broad.mit.edu	37	1	11007909	11007909	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:11007909C>T	uc010oao.1	-	8	1841	c.1836G>A	c.(1834-1836)CTG>CTA	p.L612L	C1orf127_uc001arr.1_Silent_p.L594L|C1orf127_uc001ars.1_Silent_p.L586L	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	612										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		CCCACAGGCTCAGGGTTTGCG	0.662000													5	29					0	0	0	0
PLOD1	5351	broad.mit.edu	37	1	12024727	12024727	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:12024727C>G	uc001atm.2	+	13	1446	c.1355C>G	c.(1354-1356)TCA>TGA	p.S452*	PLOD1_uc010obb.1_Nonsense_Mutation_p.S499*	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	452					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	CCCTATATTTCAAACATCTAC	0.587000													52	68					0	0	0	0
WDTC1	23038	broad.mit.edu	37	1	27632792	27632792	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:27632792T>A	uc009vst.2	+	16	2487	c.1952T>A	c.(1951-1953)ATC>AAC	p.I651N	WDTC1_uc001bno.2_Missense_Mutation_p.I650N|WDTC1_uc001bnp.1_RNA|WDTC1_uc001bnq.2_Missense_Mutation_p.I329N	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	651							protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		GGCTACCGGATCACGGGCCTG	0.647000													21	38					0	0	0	0
C1orf212	113444	broad.mit.edu	37	1	35321025	35321025	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:35321025T>C	uc001byb.2	-	2	674	c.257A>G	c.(256-258)GAG>GGG	p.E86G		NM_138428	NP_612437			hypothetical protein LOC113444												0		Myeloproliferative disorder(586;0.0393)				AATGTTCATCTCATAACTCTC	0.557000													9	42					0	0	0	0
NT5C1A	84618	broad.mit.edu	37	1	40129051	40129051	+	Silent	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:40129051G>C	uc001cdq.1	-	4	489	c.489C>G	c.(487-489)CTC>CTG	p.L163L		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	163					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GATAGGCCTTGAGGTAGCAGA	0.532000													23	29					0	0	0	0
CYP4A11	1579	broad.mit.edu	37	1	47395807	47395807	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:47395807C>T	uc001cqp.3	-	12	1591	c.1540G>A	c.(1540-1542)GAA>AAA	p.E514K		NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	514			NGIHLRLRRLPNPCEDKDQL -> MESTCVSGGSLTLVKTR TSFEGLHLPSCLPDPRFCPLPVCPYPVFCLPTFPSSHLPAV PQSACPSLSHLSPGLPTCLSTCLLPTCISCWEKS (in CYP4A11V).		long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	TCCTTGTCTTCACAAGGGTTA	0.353000													11	43					0	0	0	0
FOXE3	2301	broad.mit.edu	37	1	47882283	47882283	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:47882283G>A	uc001crk.2	+	1	540	c.296G>A	c.(295-297)CGC>CAC	p.R99H		NM_012186	NP_036318	Q13461	FOXE3_HUMAN	forkhead box E3	99	Fork-head.				cell migration|embryonic organ morphogenesis|enteric nervous system development|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|pattern specification process|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		GCCATCTACCGCTTCATCACC	0.642000													6	45					0	0	0	0
USP24	23358	broad.mit.edu	37	1	55598230	55598230	+	Silent	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:55598230G>C	uc001cyg.3	-	28	3045	c.3045C>G	c.(3043-3045)CTC>CTG	p.L1015L		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1175					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						CTAAGTTGTAGAGCACTCTGA	0.383000													29	41					0	0	0	0
C1orf168	199920	broad.mit.edu	37	1	57216842	57216842	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:57216842T>C	uc001cym.3	-	9	1668	c.1262A>G	c.(1261-1263)CAG>CGG	p.Q421R	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	421										ovary(3)|skin(2)	5						GTTGGTCATCTGAATTTTTTC	0.458000													3	48					0	0	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507588	74507588	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:74507588C>T	uc001dfy.3	-	7	1219	c.1027G>A	c.(1027-1029)GAA>AAA	p.E343K	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	343										ovary(2)	2						TCCAATTTTTCATCCACAATT	0.308000													5	40					0	0	0	0
SYCP1	6847	broad.mit.edu	37	1	115398091	115398091	+	Missense_Mutation	SNP	A	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:115398091A>C	uc001efr.2	+	2	215	c.6A>C	c.(4-6)GAA>GAC	p.E2D	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.E2D|SYCP1_uc009wgw.2_Missense_Mutation_p.E2D	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	2					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGAAAATGGAAAAGCAAAAGC	0.483000													16	44					0	0	0	0
HIST2H3D	653604	broad.mit.edu	37	1	149784921	149784921	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:149784921C>T	uc010pbl.1	-	1	316	c.316G>A	c.(316-318)GAA>AAA	p.E106K	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	106					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						TTCGTGTCTTCGAACAGCCCC	0.652000													11	51					0	0	0	0
MUC1	4582	broad.mit.edu	37	1	155161971	155161971	+	Silent	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:155161971C>G	uc010pft.1	-	2	228	c.162G>C	c.(160-162)GTG>GTC	p.V54V	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_5'Flank|MUC1_uc001fhz.2_5'Flank|MUC1_uc010pfb.1_Intron|MUC1_uc010pfc.1_Intron|MUC1_uc009wph.2_Intron|MUC1_uc010pfd.1_Intron|MUC1_uc010pfe.1_Intron|MUC1_uc010pff.1_Intron|MUC1_uc009wpi.2_Intron|MUC1_uc010pfg.1_Intron|MUC1_uc010pfh.1_Intron|MUC1_uc010pfi.1_Intron|MUC1_uc010pfj.1_Intron|MUC1_uc010pfk.1_Intron|MUC1_uc010pfl.1_Intron|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Intron|MUC1_uc001fip.2_Intron|MUC1_uc009wqg.2_Intron|MUC1_uc009wpo.2_Intron|MUC1_uc009wps.2_Intron|MUC1_uc009wpt.2_Intron|MUC1_uc001fic.2_Intron|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Intron|MUC1_uc009wpv.2_Intron|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Intron|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Intron|MUC1_uc001fid.2_Intron|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Intron|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Intron|MUC1_uc001fiq.2_Intron|MUC1_uc009wpz.2_Intron|MUC1_uc010pfn.1_Intron|MUC1_uc009wqa.2_Intron|MUC1_uc010pfo.1_Intron|MUC1_uc010pfp.1_Intron|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Intron|MUC1_uc009wqc.2_Intron|MUC1_uc009wqd.2_Intron|MUC1_uc009wqb.2_Intron|MUC1_uc010pfq.1_Intron|MUC1_uc010pfr.1_Intron|MUC1_uc001fit.2_Intron|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Intron|MUC1_uc009wpm.2_Intron|MUC1_uc009wpp.2_Intron|MUC1_uc010pfs.1_Intron|MUC1_uc001fik.2_Intron|MUC1_uc001fio.2_Intron|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Intron|MUC1_uc001fis.1_Intron|uc009wqh.2_5'Flank|MUC1_uc001fiv.1_Silent_p.V63V|MUC1_uc001fiw.1_Silent_p.V54V|MIR92B_hsa-mir-92b|MI0003560_5'Flank			P15941	MUC1_HUMAN	SubName: Full=MUC1 isoform M13;	54	Extracellular (Potential).					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGTCATACTCACAGCATTCT	0.577000			T	IGH@	B-NHL								21	115					0	0	0	0
SELE	6401	broad.mit.edu	37	1	169694892	169694892	+	Missense_Mutation	SNP	A	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:169694892A>C	uc001ggm.3	-	13	1983	c.1826T>G	c.(1825-1827)ATC>AGC	p.I609S	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	609	Cytoplasmic (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					AACTTAAAGGATGTAAGAAGG	0.408000													13	26					0	0	0	0
PRDX6	9588	broad.mit.edu	37	1	173456943	173456943	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:173456943G>T	uc001giy.1	+	5	667	c.616G>T	c.(616-618)GTC>TTC	p.V206F		NM_004905	NP_004896	P30041	PRDX6_HUMAN	peroxiredoxin 6	206					cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			central_nervous_system(1)	1						CCCGAAAGGAGTCTTCACCAA	0.478000													38	42					1.07121e-22	1.22859e-22	1	0
TDRD5	163589	broad.mit.edu	37	1	179659915	179659915	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:179659915C>G	uc001gnf.1	+	17	3033	c.2783C>G	c.(2782-2784)TCT>TGT	p.S928C	TDRD5_uc010pnp.1_Missense_Mutation_p.S982C|TDRD5_uc001gnh.1_Missense_Mutation_p.S483C	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	928					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CGTCAAGAATCTGTAGACCAG	0.438000													13	47					0	0	0	0
RGL1	23179	broad.mit.edu	37	1	183816705	183816705	+	Silent	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:183816705A>G	uc001gqo.2	+	3	301	c.144A>G	c.(142-144)GAA>GAG	p.E48E	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Silent_p.E83E|RGL1_uc010pog.1_Silent_p.E46E|RGL1_uc010poh.1_Silent_p.E46E|RGL1_uc010poi.1_Silent_p.E48E	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	48					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						TACAGGTTGAAGGGGACCAGC	0.418000													3	172					0	0	0	0
PPFIA4	8497	broad.mit.edu	37	1	203025593	203025593	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:203025593G>C	uc001gyz.2	+	5	1272	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	PPFIA4_uc009xaj.2_Missense_Mutation_p.E858Q|PPFIA4_uc010pqf.1_Missense_Mutation_p.E440Q|PPFIA4_uc001gza.2_Missense_Mutation_p.E227Q|PPFIA4_uc001gzb.1_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	227					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GCTGCGGCTAGAGAAGCTTGG	0.567000													8	30					0	0	0	0
NSL1	25936	broad.mit.edu	37	1	212965008	212965008	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:212965008C>A	uc001hjn.2	-	1	132	c.98G>T	c.(97-99)CGA>CTA	p.R33L	NSL1_uc001hjm.2_Missense_Mutation_p.R33L|NSL1_uc010pti.1_Missense_Mutation_p.R33L|TATDN3_uc001hjo.2_5'Flank|TATDN3_uc010ptj.1_5'Flank|TATDN3_uc010ptk.1_5'Flank|TATDN3_uc001hjp.2_5'Flank|TATDN3_uc010ptl.1_5'Flank	NM_015471	NP_056286	Q96IY1	NSL1_HUMAN	NSL1, MIND kinetochore complex component isoform	33					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00597)|all cancers(67;0.00893)|GBM - Glioblastoma multiforme(131;0.0514)|Epithelial(68;0.102)		AAAGTCTTCTCGGGGAGTGGC	0.632000													31	58					1.39806e-14	1.56634e-14	1	0
PTPN14	5784	broad.mit.edu	37	1	214549657	214549657	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:214549657G>A	uc001hkk.1	-	15	3083	c.2812C>T	c.(2812-2814)CGA>TGA	p.R938*	PTPN14_uc010pty.1_Nonsense_Mutation_p.R839*	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	938	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TCACGGATTCGGCTGCGCTCG	0.458000													31	55					0	0	0	0
LIN9	286826	broad.mit.edu	37	1	226465500	226465500	+	Silent	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:226465500G>A	uc001hqa.2	-	7	1016	c.706C>T	c.(706-708)CTG>TTG	p.L236L	LIN9_uc001hqb.2_Silent_p.L201L|LIN9_uc001hqc.2_Silent_p.L168L|LIN9_uc009xel.1_Silent_p.L201L	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	220	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		CCAATAACCAGAGGCAAAGGA	0.333000													12	48					0	0	0	0
OR2M5	127059	broad.mit.edu	37	1	248309245	248309245	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:248309245C>T	uc010pze.1	+	1	796	c.796C>T	c.(796-798)CGC>TGC	p.R266C		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CACATCTGATCGCTCCCCTAT	0.522000													65	94					0	0	0	0
OR2T6	254879	broad.mit.edu	37	1	248551737	248551737	+	Silent	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:248551737C>A	uc001iei.1	+	1	828	c.828C>A	c.(826-828)GCC>GCA	p.A276A		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCTTCTCTGCCTTTTATACCA	0.463000													16	69					4.7546e-09	5.11384e-09	1	0
USP6NL	9712	broad.mit.edu	37	10	11505446	11505446	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr10:11505446G>A	uc001ikt.3	-	15	1802	c.1481C>T	c.(1480-1482)TCA>TTA	p.S494L	USP6NL_uc001iks.1_Missense_Mutation_p.S511L	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	494						intracellular	Rab GTPase activator activity				0						CTCTGTAGCTGAGACGTCTGA	0.537000													46	206					0	0	0	0
MYO3A	53904	broad.mit.edu	37	10	26409613	26409613	+	Silent	SNP	T	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr10:26409613T>C	uc001isn.2	+	18	2145	c.1785T>C	c.(1783-1785)GGT>GGC	p.G595G	MYO3A_uc009xko.1_Silent_p.G595G|MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	595	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AGCAACTTGGTAGTATATACA	0.438000													12	70					0	0	0	0
TSPAN14	81619	broad.mit.edu	37	10	82269077	82269077	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr10:82269077C>T	uc001kcj.3	+	5	407	c.300C>T	c.(298-300)CTC>CTT	p.L100L	TSPAN14_uc009xss.2_Intron|TSPAN14_uc001kci.3_Silent_p.L83L	NM_030927	NP_112189	Q8NG11	TSN14_HUMAN	tetraspanin 14 isoform 1	100	Helical; (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)			CCATCGTGCTCATCTTCTTCC	0.612000													23	28					0	0	0	0
CUEDC2	79004	broad.mit.edu	37	10	104184490	104184490	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr10:104184490G>C	uc001kvn.2	-	3	285	c.134C>G	c.(133-135)TCG>TGG	p.S45W	CUEDC2_uc001kvm.2_5'Flank	NM_024040	NP_076945	Q9H467	CUED2_HUMAN	CUE domain containing 2	45						cytoplasm|nucleus	protein binding				0		Colorectal(252;0.122)		Epithelial(162;9.17e-09)|all cancers(201;2.16e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		TGATGGGCCCGAGGGGCCCAG	0.587000													30	43					0	0	0	0
DOCK1	1793	broad.mit.edu	37	10	129141970	129141970	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr10:129141970G>C	uc001ljt.2	+	31	3185	c.3121G>C	c.(3121-3123)GAG>CAG	p.E1041Q	DOCK1_uc010qun.1_Missense_Mutation_p.E1062Q|DOCK1_uc009yaq.2_Missense_Mutation_p.E36Q	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1041					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CCTGCAACTGGAGAATTTTTC	0.433000													2	7					0	0	0	0
HBD	3045	broad.mit.edu	37	11	5255269	5255269	+	Silent	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:5255269C>G	uc001maf.1	-	2	462	c.267G>C	c.(265-267)CTG>CTC	p.L89L		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	89					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAGCTCACTCAGCTGAGAAA	0.493000													30	60					0	0	0	0
ABCC8	6833	broad.mit.edu	37	11	17427072	17427072	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:17427072C>G	uc001mnc.2	-	27	3494	c.3368G>C	c.(3367-3369)AGA>ACA	p.R1123T		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1123	Cytoplasmic (By similarity).|ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGATGAAAATCTGTTCAGGAT	0.512000													46	101					0	0	0	0
SLC6A5	9152	broad.mit.edu	37	11	20622705	20622705	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:20622705C>G	uc001mqd.2	+	2	307	c.34C>G	c.(34-36)CTG>GTG	p.L12V	SLC6A5_uc009yic.2_5'UTR	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	12	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	AATGAATAAACTGCCAGCCAA	0.572000													6	17					0	0	0	0
Unknown	0	broad.mit.edu	37	11	48328704	48328704	+	IGR	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:48328704A>G								OR4S1 (1 upstream) : OR4C3 (17789 downstream)																							GGGAGAAGTGACATTCCAGAG	0.428000													10	33					0	0	0	0
RPLP0P2	113157	broad.mit.edu	37	11	61404539	61404539	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:61404539C>G	uc001nrz.1	+	5	1143	c.388C>G	c.(388-390)CTG>GTG	p.L130V		NR_002775				SubName: Full=cDNA FLJ51469, highly similar to 60S acidic ribosomal protein P0;												0						GAATACTGGTCTGGACCCCGA	0.542000													15	25					0	0	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793518	65793518	+	Silent	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:65793518G>A	uc001ogt.2	-	1	471	c.333C>T	c.(331-333)TAC>TAT	p.Y111Y		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	111	His-rich.|Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						AGTCCTCACCGTAGGAACGGT	0.597000													22	125					0	0	0	0
ARAP1	116985	broad.mit.edu	37	11	72406446	72406446	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:72406446C>G	uc001osu.2	-	26	3751	c.3562G>C	c.(3562-3564)GAG>CAG	p.E1188Q	ARAP1_uc001osv.2_Missense_Mutation_p.E1188Q|ARAP1_uc001osr.2_Missense_Mutation_p.E948Q|ARAP1_uc001oss.2_Missense_Mutation_p.E943Q|ARAP1_uc009yth.2_Missense_Mutation_p.E882Q|ARAP1_uc010rre.1_Missense_Mutation_p.E943Q	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1188	Ras-associating.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						ATATGCTGCTCAGTCTCTGCC	0.577000													14	52					0	0	0	0
ARAP1	116985	broad.mit.edu	37	11	72406880	72406880	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:72406880C>T	uc001osu.2	-	24	3492	c.3303G>A	c.(3301-3303)ATG>ATA	p.M1101I	ARAP1_uc001osv.2_Missense_Mutation_p.M1101I|ARAP1_uc001osr.2_Missense_Mutation_p.M861I|ARAP1_uc001oss.2_Missense_Mutation_p.M856I|ARAP1_uc009yth.2_Missense_Mutation_p.M795I|ARAP1_uc010rre.1_Missense_Mutation_p.M856I	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1101	Rho-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						TGTGCACGTTCATCTGGTTCG	0.537000													14	23					0	0	0	0
C2CD3	26005	broad.mit.edu	37	11	73789689	73789689	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:73789689C>G	uc001ouu.2	-	23	4301	c.4074G>C	c.(4072-4074)AAG>AAC	p.K1358N	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1358						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					CACCCACGATCTTCTGCATGA	0.498000													41	71					0	0	0	0
ODZ4	26011	broad.mit.edu	37	11	78381038	78381038	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:78381038C>T	uc001ozl.3	-	32	6815	c.6352G>A	c.(6352-6354)GAG>AAG	p.E2118K	ODZ4_uc001ozk.3_Missense_Mutation_p.E343K|ODZ4_uc009yvb.1_Missense_Mutation_p.E702K	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2118	YD 14.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CCAAACTGCTCTGTCTTGCCT	0.478000													19	26					0	0	0	0
CASP1	834	broad.mit.edu	37	11	104901918	104901918	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:104901918T>C	uc010rve.1	-	4	444	c.427A>G	c.(427-429)AGG>GGG	p.R143G	CASP1_uc001pig.2_Missense_Mutation_p.R50G|CASP1_uc001pik.2_Missense_Mutation_p.R106G|CASP1_uc010rvf.1_Missense_Mutation_p.R50G|CASP1_uc010rvg.1_Missense_Mutation_p.R122G|CASP1_uc010rvh.1_Missense_Mutation_p.R50G|CASP1_uc010rvi.1_Intron|CASP1_uc001pim.3_Missense_Mutation_p.R143G|CASP1_uc009yxi.2_Missense_Mutation_p.R122G|CASP1_uc010rvj.1_Missense_Mutation_p.R143G|CASP1_uc009yxj.2_Intron|CASP1_uc010rvk.1_Missense_Mutation_p.R104G|CASP1_uc010rvl.1_Missense_Mutation_p.R143G	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	143					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TTCCATATCCTTTGAGCTTCT	0.507000													16	24					0	0	0	0
MLL	4297	broad.mit.edu	37	11	118339526	118339526	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:118339526G>A	uc001pta.2	+	2	492	c.469G>A	c.(469-471)GTC>ATC	p.V157I	MLL_uc001ptb.2_Missense_Mutation_p.V157I|MLL_uc001psz.1_Missense_Mutation_p.V190I|MLL_uc001ptd.1_5'UTR	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	157					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AGATGAAGAAGTCAGAGTGCG	0.408000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								19	28					0	0	0	0
SLC37A4	2542	broad.mit.edu	37	11	118895769	118895769	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:118895769C>T	uc010rys.1	-	11	1898	c.1141G>A	c.(1141-1143)GGG>AGG	p.G381R	SLC37A4_uc009zam.2_RNA|SLC37A4_uc009zan.2_RNA|SLC37A4_uc010ryr.1_Missense_Mutation_p.G403R|SLC37A4_uc010ryt.1_Missense_Mutation_p.G308R|SLC37A4_uc001pus.2_Missense_Mutation_p.G381R	NM_001164277	NP_001157749	O43826	G6PT1_HUMAN	solute carrier family 37 (glucose-6-phosphate	381	Helical; (Potential).				glucose homeostasis|glucose metabolic process	endoplasmic reticulum membrane|integral to endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphate transmembrane transporter activity|glucose-6-phosphate transmembrane transporter activity			large_intestine(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		AAGGGCAGCCCAGCCAGAAAG	0.582000									Glycogen_Storage_Disease_type_Ib				30	53					0	0	0	0
MFRP	83552	broad.mit.edu	37	11	119214569	119214569	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:119214569C>A	uc001pwj.2	-	9	1241	c.1081G>T	c.(1081-1083)GTG>TTG	p.V361L	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Intron	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		GTCTCATACACCTCCACGTAG	0.582000													38	83					4.32679e-17	4.91589e-17	1	0
EI24	9538	broad.mit.edu	37	11	125453532	125453532	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:125453532C>A	uc001qca.2	+	12	1219	c.977C>A	c.(976-978)TCA>TAA	p.S326*	EI24_uc001qcb.2_3'UTR|EI24_uc010sbd.1_RNA|EI24_uc009zbl.2_Nonsense_Mutation_p.S327*|EI24_uc001qcc.2_RNA|EI24_uc010sbe.1_Nonsense_Mutation_p.S313*|EI24_uc010sbf.1_RNA	NM_004879	NP_004870	O14681	EI24_HUMAN	etoposide induced 2.4 isoform 1	326					apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		AAGTTCCCTTCACCGCATCCG	0.552000													15	22					1.3612e-06	1.44479e-06	1	0
SLCO1A2	6579	broad.mit.edu	37	12	21471722	21471722	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:21471722C>G	uc001rer.2	-	2	447	c.196G>C	c.(196-198)GAG>CAG	p.E66Q	SLCO1A2_uc001res.2_Missense_Mutation_p.E66Q|SLCO1A2_uc010siq.1_5'UTR|SLCO1A2_uc010sio.1_5'UTR|SLCO1A2_uc010sip.1_Intron|SLCO1A2_uc001ret.2_Missense_Mutation_p.E64Q|SLCO1A2_uc001reu.2_Missense_Mutation_p.E46Q	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	66	Helical; Name=2; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TTACCAATCTCAAAGCTTCCA	0.328000													23	61					0	0	0	0
IFLTD1	160492	broad.mit.edu	37	12	25672833	25672833	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:25672833G>C	uc001rgs.2	-	6	1062	c.912C>G	c.(910-912)ATC>ATG	p.I304M	IFLTD1_uc001rgt.1_Missense_Mutation_p.I207M|IFLTD1_uc010sji.1_Missense_Mutation_p.I325M|IFLTD1_uc010sjj.1_Missense_Mutation_p.I241M|IFLTD1_uc009zjc.2_Missense_Mutation_p.I285M	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	304						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					GATAATTTGAGATATCTTTCT	0.373000													18	40					0	0	0	0
C12orf41	54934	broad.mit.edu	37	12	49073534	49073534	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:49073534C>T	uc001rrx.2	-	3	409	c.334G>A	c.(334-336)GGT>AGT	p.G112S	C12orf41_uc001rrw.2_5'UTR|C12orf41_uc001rrz.2_Missense_Mutation_p.G295S|C12orf41_uc001rry.2_RNA	NM_017822	NP_060292	Q9H9L4	CL041_HUMAN	hypothetical protein LOC54934	112										ovary(2)	2						AGTGTTTCACCCACAGGCCCT	0.507000													6	17					0	0	0	0
EIF4B	1975	broad.mit.edu	37	12	53410267	53410267	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:53410267G>C	uc001sbh.3	+	2	230	c.24G>C	c.(22-24)AAG>AAC	p.K8N	EIF4B_uc009zmp.1_RNA|EIF4B_uc010snu.1_Missense_Mutation_p.K8N|EIF4B_uc010snv.1_Missense_Mutation_p.K8N|EIF4B_uc001sbi.2_5'UTR	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	8					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						CAAAAAAGAAGAATAAGAAGG	0.393000													10	29					0	0	0	0
TIMELESS	8914	broad.mit.edu	37	12	56816656	56816656	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:56816656C>T	uc001slf.2	-	19	2581	c.2413G>A	c.(2413-2415)GAG>AAG	p.E805K		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	805					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CCATAGCCCTCAGTCATCTCT	0.448000													38	59					0	0	0	0
LGR5	8549	broad.mit.edu	37	12	71965319	71965319	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:71965319G>C	uc001swl.2	+	12	1144	c.1096G>C	c.(1096-1098)GAT>CAT	p.D366H	LGR5_uc001swm.2_Missense_Mutation_p.D342H|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	366	LRR 13.|Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						CCTATTAGAAGATTTACCCAG	0.338000													7	28					0	0	0	0
KSR2	283455	broad.mit.edu	37	12	118105354	118105354	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:118105354G>A	uc001two.2	-	5	1064	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	366					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAGAAGGAGCGGAGGGAGCGC	0.602000													11	19					0	0	0	0
GCN1L1	10985	broad.mit.edu	37	12	120600729	120600729	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:120600729C>T	uc001txo.2	-	20	2098	c.2085G>A	c.(2083-2085)AAG>AAA	p.K695K		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	695					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGGATCGATCTTCATCCTGG	0.557000													38	74					0	0	0	0
KNTC1	9735	broad.mit.edu	37	12	123061462	123061462	+	Silent	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr12:123061462C>G	uc001ucv.2	+	30	2770	c.2607C>G	c.(2605-2607)CTC>CTG	p.L869L	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	869					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GATACATTCTCAAACAAGATG	0.348000													14	21					0	0	0	0
LOC284232	284232	broad.mit.edu	37	13	19413025	19413025	+	RNA	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr13:19413025A>G	uc010tcj.1	-	1		c.33085T>C				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						AATAACCTGCACATCCATGCA	0.299000													5	25					0	0	0	0
LOC284232	284232	broad.mit.edu	37	13	19413033	19413033	+	RNA	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr13:19413033G>A	uc010tcj.1	-	1		c.33077C>T				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						GCACATCCATGCACTAAAAAG	0.294000													5	24					0	0	0	0
LMO7	4008	broad.mit.edu	37	13	76381901	76381901	+	Silent	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr13:76381901A>G	uc001vjv.2	+	7	1543	c.783A>G	c.(781-783)GTA>GTG	p.V261V	LMO7_uc010thv.1_Intron|LMO7_uc001vjt.1_Intron|LMO7_uc010thw.1_Intron|LMO7_uc001vjw.1_Silent_p.V167V	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	546						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		ATGATTCTGTAGAGCGAGATA	0.388000													30	59					0	0	0	0
DOCK9	23348	broad.mit.edu	37	13	99498246	99498246	+	Splice_Site	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr13:99498246C>G	uc001vnt.2	-	38	4120	c.4065_splice	c.e38-1	p.R1355_splice	DOCK9_uc001vnw.2_Splice_Site_p.R1354_splice|DOCK9_uc001vnv.1_Splice_Site|DOCK9_uc010tir.1_Splice_Site_p.R1355_splice|DOCK9_uc001vnq.2_5'UTR|DOCK9_uc001vnr.2_5'UTR|DOCK9_uc010tin.1_5'UTR|DOCK9_uc001vns.2_Intron|DOCK9_uc010tio.1_Missense_Mutation_p.R47T|DOCK9_uc010tip.1_Missense_Mutation_p.R65T|DOCK9_uc001vnu.1_5'UTR|DOCK9_uc010tiq.1_Splice_Site_p.R333_splice	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a						blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CATTCCTGTTCTGTTACGGGA	0.483000													7	16					0	0	0	0
MYH7	4625	broad.mit.edu	37	14	23893298	23893298	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr14:23893298G>T	uc001wjx.2	-	23	2846	c.2740C>A	c.(2740-2742)CAG>AAG	p.Q914K		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	914	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCCTCCAGCTGAATCTTGTTT	0.532000													28	66					2.44723e-14	2.72917e-14	1	0
FSCB	84075	broad.mit.edu	37	14	44975541	44975541	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr14:44975541G>A	uc001wvn.2	-	1	959	c.650C>T	c.(649-651)TCA>TTA	p.S217L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	217						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CTGAGTAAATGAAGTTCTGCT	0.393000													26	64					0	0	0	0
C14orf49	161176	broad.mit.edu	37	14	95906295	95906295	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr14:95906295C>G	uc001yei.3	-	11	2044	c.2029G>C	c.(2029-2031)GAG>CAG	p.E677Q	C14orf49_uc010avi.2_Missense_Mutation_p.E677Q	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	677	Spectrin 2.|Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		GGGCCCGCCTCTCCCCGGTGT	0.637000													75	66					0	0	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102504835	102504835	+	Silent	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr14:102504835G>C	uc001yks.2	+	58	11111	c.10947G>C	c.(10945-10947)CTG>CTC	p.L3649L		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3649	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding	p.L3649V(1)		ovary(7)|central_nervous_system(2)|pancreas(1)	10						ACCCGGTGCTGAACCGTGAAG	0.542000													7	34					0	0	0	0
LOC646214	646214	broad.mit.edu	37	15	21937369	21937369	+	RNA	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:21937369C>T	uc010tzj.1	-	1		c.3371G>A				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						GCCCCTTGTCCAATTTTTTCA	0.368000													15	185					0	0	0	0
ATP10A	57194	broad.mit.edu	37	15	25953381	25953381	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:25953381G>A	uc010ayu.2	-	11	2517	c.2411C>T	c.(2410-2412)GCG>GTG	p.A804V		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	804	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCCTTCCGCCGCATACACGTT	0.567000													4	132					0	0	0	0
EPB42	2038	broad.mit.edu	37	15	43508574	43508574	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:43508574G>A	uc001zra.3	-	2	388	c.88C>T	c.(88-90)CGC>TGC	p.R30C	EPB42_uc010bde.2_5'UTR|EPB42_uc001zrb.3_Missense_Mutation_p.R60C|EPB42_uc010udm.1_Missense_Mutation_p.R30C	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	30					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		ACAAAGAGGCGCCGGGAGCTG	0.582000													27	50					0	0	0	0
CATSPER2	117155	broad.mit.edu	37	15	43924464	43924464	+	Silent	SNP	T	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:43924464T>C	uc001zsh.2	-	12	1709	c.1494A>G	c.(1492-1494)CGA>CGG	p.R498R	STRC_uc010udz.1_RNA|CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Silent_p.R496R|CATSPER2_uc001zsj.2_Silent_p.R496R	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	498	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		ACTCAAAATATCGGAAGAGTG	0.483000													21	53					0	0	0	0
SHC4	399694	broad.mit.edu	37	15	49126974	49126974	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:49126974C>T	uc001zxb.1	-	11	2158	c.1729G>A	c.(1729-1731)GAA>AAA	p.E577K	SHC4_uc010uey.1_Missense_Mutation_p.E334K|SHC4_uc010uez.1_Missense_Mutation_p.E291K	NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	577	SH2.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		ACCTTGCCTTCAGGATCCACC	0.453000													33	85					0	0	0	0
LACTB	114294	broad.mit.edu	37	15	63419597	63419597	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:63419597C>T	uc002alw.2	+	4	700	c.661C>T	c.(661-663)CGT>TGT	p.R221C	LACTB_uc002alv.2_Missense_Mutation_p.R221C	NM_032857	NP_116246	P83111	LACTB_HUMAN	lactamase, beta isoform a	221						mitochondrion	hydrolase activity				0						AAGTGGAATTCGTCATTATGA	0.299000													34	85					0	0	0	0
CSPG4	1464	broad.mit.edu	37	15	75982391	75982391	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:75982391G>A	uc002baw.2	-	3	1108	c.1015C>T	c.(1015-1017)CGC>TGC	p.R339C		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	339	Extracellular (Potential).|Neurite growth inhibition (By similarity).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						AGGCCCAGGCGGTGTTCCTGG	0.642000													5	37					0	0	0	0
C15orf27	123591	broad.mit.edu	37	15	76426621	76426621	+	Missense_Mutation	SNP	C	G	G	rs114291110	by1000genomes	TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:76426621C>G	uc002bbq.2	+	2	172	c.17C>G	c.(16-18)TCT>TGT	p.S6C	C15orf27_uc010bkp.2_Translation_Start_Site	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	6						integral to membrane					0						GTGGCTCCATCTTTCAACATG	0.463000													26	38					0	0	0	0
IL16	3603	broad.mit.edu	37	15	81565513	81565513	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr15:81565513G>T	uc002bgh.3	+	6	1134	c.758G>T	c.(757-759)GGA>GTA	p.G253V	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.G253V|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.G295V|IL16_uc002bgg.2_Missense_Mutation_p.G253V	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	253	Interaction with GRIN2A.|PDZ 1.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						TTTGCAGGGGGAGCAGCAGCA	0.522000													18	42					6.49762e-13	7.14738e-13	1	0
IFT140	9742	broad.mit.edu	37	16	1573848	1573848	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:1573848G>A	uc002cmb.2	-	25	3613	c.3251C>T	c.(3250-3252)GCG>GTG	p.A1084V	IFT140_uc002clz.2_Missense_Mutation_p.A697V	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	1084	TPR 6.									ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				CAGCATGACCGCCCTGTCCAT	0.672000													13	38					0	0	0	0
FAM100A	124402	broad.mit.edu	37	16	4664715	4664715	+	Silent	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:4664715C>G	uc002cwx.2	-	1	213	c.84G>C	c.(82-84)GCG>GCC	p.A28A	FAM100A_uc010btv.1_Silent_p.A28A|FAM100A_uc002cwy.2_Silent_p.A28A	NM_145253	NP_660296	Q8TB05	F100A_HUMAN	hypothetical protein LOC124402	28											0						GCAGTTGCTTCGCCTGGTCGG	0.731000													4	23					0	0	0	0
CORO1A	11151	broad.mit.edu	37	16	30199820	30199820	+	Missense_Mutation	SNP	C	T	T	rs150186033	byFrequency	TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:30199820C>T	uc002dww.2	+	10	1326	c.1204C>T	c.(1204-1206)CGG>TGG	p.R402W	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Missense_Mutation_p.R402W|CORO1A_uc010bzr.2_Intron|CORO1A_uc002dwx.2_Missense_Mutation_p.R296W|CORO1A_uc002dwy.1_3'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	402					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						CCCAAAGAGCCGGGAGCTGAG	0.701000													20	29					0	0	0	0
BBS2	583	broad.mit.edu	37	16	56539947	56539947	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:56539947G>A	uc002ejd.2	-	7	953	c.719C>T	c.(718-720)TCG>TTG	p.S240L	BBS2_uc010ccg.2_Missense_Mutation_p.S240L	NM_031885	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein	240					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1						ATGATTTTTCGACTGAAAAAG	0.343000									Bardet-Biedl_syndrome				10	24					0	0	0	0
PKD1L2	114780	broad.mit.edu	37	16	81219116	81219116	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:81219116C>A	uc002fgh.1	-	11	1978	c.1978G>T	c.(1978-1980)GAA>TAA	p.E660*	PKD1L2_uc002fgj.2_Nonsense_Mutation_p.E660*	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	660	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCCTGAGTTCCCAGGGCGCA	0.542000													9	23					0.000274275	0.000283652	1	0
ZZEF1	23140	broad.mit.edu	37	17	3979948	3979948	+	Missense_Mutation	SNP	C	T	T	rs143736611	byFrequency	TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:3979948C>T	uc002fxe.2	-	21	3281	c.3217G>A	c.(3217-3219)GAA>AAA	p.E1073K	ZZEF1_uc002fxk.1_Missense_Mutation_p.E1074K	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1073							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGTCCTCCTTCGGGGCCACTA	0.552000													10	26					0	0	0	0
ZZEF1	23140	broad.mit.edu	37	17	3981229	3981229	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:3981229C>T	uc002fxe.2	-	19	3001	c.2937G>A	c.(2935-2937)CTG>CTA	p.L979L	ZZEF1_uc002fxk.1_Silent_p.L980L	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	979							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCGTGCTCTTCAGCTGCAGGT	0.512000													24	46					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578203	7578203	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:7578203C>T	uc002gim.2	-	6	840	c.646G>A	c.(646-648)GTG>ATG	p.V216M	TP53_uc002gig.1_Missense_Mutation_p.V216M|TP53_uc002gih.2_Missense_Mutation_p.V216M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V84M|TP53_uc010cng.1_Missense_Mutation_p.V84M|TP53_uc002gii.1_Missense_Mutation_p.V84M|TP53_uc010cnh.1_Missense_Mutation_p.V216M|TP53_uc010cni.1_Missense_Mutation_p.V216M|TP53_uc002gij.2_Missense_Mutation_p.V216M|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.V123M|TP53_uc002gio.2_Missense_Mutation_p.V84M|TP53_uc010vug.1_Missense_Mutation_p.V177M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	216	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> A (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> M (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V216M(49)|p.V216del(8)|p.0?(7)|p.V216L(7)|p.V216E(4)|p.V216G(3)|p.V216A(3)|p.V216fs*6(2)|p.V216fs*31(2)|p.H214fs*5(2)|p.K164_P219del(1)|p.V216fs*32(1)|p.V216fs*33(1)|p.S215fs*27(1)|p.S215fs*29(1)|p.V216fs*5(1)|p.V216_Y220delVVVPY(1)|p.D208_V216delDRNTFRHSV(1)|p.D208fs*1(1)|p.V216fs*28(1)|p.S215fs*31(1)|p.S215_V216insX(1)|p.T211fs*28(1)|p.D207_V216del10(1)|p.S215_V218>R(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACCACCACACTATGTCGA	0.537000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			27	10					0	0	0	0
MYH8	4626	broad.mit.edu	37	17	10322343	10322343	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:10322343A>G	uc002gmm.2	-	4	310	c.215T>C	c.(214-216)CTA>CCA	p.L72P	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	72	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CCTGACAGTTAGAGTCTGGTG	0.313000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				26	45					0	0	0	0
FLII	2314	broad.mit.edu	37	17	18151261	18151261	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:18151261C>T	uc002gsr.1	-	19	2328	c.2277G>A	c.(2275-2277)CTG>CTA	p.L759L	FLII_uc002gsq.1_Silent_p.L630L|FLII_uc010cpy.1_Silent_p.L748L|FLII_uc010vxn.1_Silent_p.L728L|FLII_uc010vxo.1_Silent_p.L704L|FLII_uc002gss.1_Silent_p.L758L	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	759	Interaction with ACTL6A.|Gelsolin-like 3.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					TTCTTGGCATCAGCTCCACCT	0.617000													32	73					0	0	0	0
SOCS7	30837	broad.mit.edu	37	17	36552194	36552194	+	Silent	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:36552194G>A	uc002hqa.2	+	9	1842	c.1719G>A	c.(1717-1719)CAG>CAA	p.Q573Q	SOCS7_uc010cvl.2_Silent_p.Q539Q|SOCS7_uc002hqb.2_Intron	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	573					intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					TTTCCAAACAGAAGCAAGAGG	0.512000													18	31					0	0	0	0
MLLT6	4302	broad.mit.edu	37	17	36872785	36872785	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:36872785C>T	uc002hqi.3	+	10	1215	c.1202C>T	c.(1201-1203)TCT>TTT	p.S401F	MLLT6_uc002hqj.2_Intron|MLLT6_uc002hqk.3_5'Flank	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	401					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					GTGGTCTTCTCTGGCTTTGGG	0.657000			T	MLL	AL								30	42					0	0	0	0
PGAP3	93210	broad.mit.edu	37	17	37840929	37840929	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:37840929C>T	uc002hsj.2	-	3	396	c.353G>A	c.(352-354)AGC>AAC	p.S118N	PGAP3_uc010cvy.2_RNA|PGAP3_uc010wej.1_Missense_Mutation_p.S118N|PGAP3_uc002hsk.2_Intron|PGAP3_uc010cvz.2_Missense_Mutation_p.S118N	NM_033419	NP_219487	Q96FM1	PGAP3_HUMAN	per1-like domain containing 1 precursor	118	Helical; (Potential).				GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			upper_aerodigestive_tract(1)	1						CATCACCAGGCTGGCCAGGCC	0.602000													18	26					0	0	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	C	C	rs141357429	by1000genomes	TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:39274087G>C	uc002hvz.2	-	1	520	c.481C>G	c.(481-483)CTG>GTG	p.L161V		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.323000													4	22					0	0	0	0
NKIRAS2	28511	broad.mit.edu	37	17	40174467	40174467	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:40174467A>G	uc002hyq.2	+	3	210	c.145A>G	c.(145-147)ACA>GCA	p.T49A	NKIRAS2_uc010wgd.1_Missense_Mutation_p.T49A|NKIRAS2_uc002hyr.2_Missense_Mutation_p.T49A|NKIRAS2_uc002hys.2_Missense_Mutation_p.T49A|NKIRAS2_uc010wge.1_Missense_Mutation_p.T49A|NKIRAS2_uc002hyt.2_Missense_Mutation_p.T49A	NM_001001349	NP_001001349	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2 isoform a	49	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			ovary(1)	1		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				CTCCATTGAGACAGACCGGGG	0.557000													27	42					0	0	0	0
GPATCH8	23131	broad.mit.edu	37	17	42483420	42483420	+	Splice_Site	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:42483420C>G	uc002igw.1	-	7	557	c.493_splice	c.e7-1	p.R165_splice	GPATCH8_uc002igv.1_Splice_Site_p.R87_splice|GPATCH8_uc010wiz.1_Splice_Site_p.R87_splice	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8							intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CTTTTAATCTCTGGGTTAAAA	0.433000													18	29					0	0	0	0
AKAP1	8165	broad.mit.edu	37	17	55182885	55182885	+	Silent	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:55182885C>A	uc002iux.2	+	2	291	c.60C>A	c.(58-60)CTC>CTA	p.L20L	AKAP1_uc010wnl.1_Silent_p.L20L|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Silent_p.L20L	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	20					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					TGGCGCTCCTCGGCTGGTGGT	0.577000													22	32					1.87028e-06	1.97646e-06	1	0
MED13	9969	broad.mit.edu	37	17	60042437	60042437	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:60042437G>C	uc002izo.2	-	20	4851	c.4774C>G	c.(4774-4776)CTA>GTA	p.L1592V		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1592					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GCTGTCTGTAGAGCTGATGTC	0.453000													12	41					0	0	0	0
DNAI2	64446	broad.mit.edu	37	17	72308173	72308173	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:72308173T>A	uc002jkf.2	+	12	1625	c.1526T>A	c.(1525-1527)ATC>AAC	p.I509N	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_5'Flank|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	509					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CGAGAGAAGATCCTGGAGGCC	0.652000									Kartagener_syndrome				14	21					0	0	0	0
CDR2L	30850	broad.mit.edu	37	17	72997458	72997458	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr17:72997458C>T	uc002jml.3	+	3	627	c.215C>T	c.(214-216)ACG>ATG	p.T72M		NM_014603	NP_055418	Q86X02	CDR2L_HUMAN	cerebellar degeneration-related protein 2-like	72	Potential.										0	all_lung(278;0.226)					CAGCTGGACACGCTGCGGCAC	0.562000													6	21					0	0	0	0
SMAD4	4089	broad.mit.edu	37	18	48584552	48584552	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr18:48584552C>G	uc010xdp.1	+	6	1263	c.725C>G	c.(724-726)TCA>TGA	p.S242*	SMAD4_uc010xdo.1_RNA|SMAD4_uc002lfb.3_Nonsense_Mutation_p.S87*	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	242					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CAGATAGCATCAGGGCCTCAG	0.433000									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				21	14					0	0	0	0
APBA3	9546	broad.mit.edu	37	19	3759797	3759797	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:3759797C>G	uc002lyp.1	-	2	643	c.466G>C	c.(466-468)GAG>CAG	p.E156Q	MRPL54_uc002lyq.3_5'Flank	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	156					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGCCCCCTCCACCCATTCT	0.642000													10	33					0	0	0	0
GDF1	2657	broad.mit.edu	37	19	18990068	18990068	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:18990068C>T	uc002nki.1	-	5	954	c.882G>A	c.(880-882)ATG>ATA	p.M294I	LASS1_uc002nkj.2_Missense_Mutation_p.M294I|LASS1_uc010ebx.2_Missense_Mutation_p.M196I	NM_021267	NP_067090	P27539	GDF1_HUMAN	LAG1 homolog, ceramide synthase 1 isoform 1	Error:Variant_position_missing_in_P27539_after_alignment					growth	extracellular space	cytokine activity|growth factor activity				0						AGTAGAGGTTCATAAGGGTGA	0.612000													4	27					0	0	0	0
ZNF254	9534	broad.mit.edu	37	19	24309211	24309211	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:24309211G>A	uc002nru.2	+	4	543	c.409G>A	c.(409-411)GAA>AAA	p.E137K	ZNF254_uc010xrk.1_Missense_Mutation_p.E52K	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	137					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				GGTGAACAAAGAAGGTTATAA	0.299000													23	34					0	0	0	0
MAG	4099	broad.mit.edu	37	19	35790470	35790470	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:35790470C>T	uc002nyy.1	+	5	578	c.429C>T	c.(427-429)ATC>ATT	p.I143I	MAG_uc002nyx.1_Silent_p.I143I|MAG_uc010eds.1_Silent_p.I118I|MAG_uc002nyz.1_Silent_p.I143I	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	143	Ig-like C2-type 1.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCCCCAACATCGTGGTGCCCC	0.672000													3	19					0	0	0	0
HSD17B14	51171	broad.mit.edu	37	19	49316972	49316972	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:49316972T>C	uc002pkv.1	-	7	756	c.490A>G	c.(490-492)ATG>GTG	p.M164V	BCAT2_uc002pkq.3_5'Flank|BCAT2_uc002pkr.2_5'Flank|BCAT2_uc002pks.2_5'Flank|BCAT2_uc002pkt.2_5'Flank|BCAT2_uc010emh.1_5'Flank|BCAT2_uc010emi.1_5'Flank|BCAT2_uc010emj.1_5'Flank|HSD17B14_uc010emk.1_Missense_Mutation_p.M164V	NM_016246	NP_057330	Q9BPX1	DHB14_HUMAN	dehydrogenase/reductase (SDR family) member 10	164					steroid catabolic process	centrosome|cytosol	estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity				0		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000341)|all cancers(93;0.000764)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.0346)		GCTTTGGTCATGGCTGTTACT	0.612000													41	58					0	0	0	0
CPT1C	126129	broad.mit.edu	37	19	50204760	50204760	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:50204760G>C	uc002ppj.2	+	6	767	c.562G>C	c.(562-564)GAG>CAG	p.E188Q	CPT1C_uc002ppl.3_Missense_Mutation_p.E154Q|CPT1C_uc002ppi.2_Missense_Mutation_p.E105Q|CPT1C_uc002ppk.2_Missense_Mutation_p.E188Q|CPT1C_uc010eng.2_Missense_Mutation_p.E188Q|CPT1C_uc010enh.2_Missense_Mutation_p.E188Q|CPT1C_uc010ybc.1_Missense_Mutation_p.E26Q	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	188	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTAGTACCTGGAGTCGGTCCG	0.577000													14	32					0	0	0	0
PTOV1	53635	broad.mit.edu	37	19	50361359	50361359	+	Silent	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:50361359G>A	uc002pqf.1	+	9	1094	c.924G>A	c.(922-924)CCG>CCA	p.P308P	PTOV1_uc002ppz.3_RNA|PTOV1_uc002pqb.3_Silent_p.P276P|PTOV1_uc002pqa.2_RNA|PTOV1_uc002pqc.1_RNA|PTOV1_uc002pqd.2_RNA|PTOV1_uc002pqe.1_RNA	NM_017432	NP_059128	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	308	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		AGCTCATCCCGCAGCAGCTGC	0.687000													12	30					0	0	0	0
PNKP	11284	broad.mit.edu	37	19	50368399	50368399	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:50368399C>T	uc002pqh.2	-	3	535	c.483G>A	c.(481-483)GTG>GTA	p.V161V	PNKP_uc002pqg.2_5'UTR|PNKP_uc002pqi.2_Silent_p.V122V|PNKP_uc002pqj.2_Silent_p.V161V|PNKP_uc010enm.2_Silent_p.V161V|PNKP_uc002pqk.2_Silent_p.V161V	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	161					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		CCTGGGGTTTCACCCCAGCTG	0.552000								Other_BER_factors					5	21					0	0	0	0
ZFP28	140612	broad.mit.edu	37	19	57061542	57061542	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:57061542G>T	uc002qnj.2	+	6	865	c.794G>T	c.(793-795)GGA>GTA	p.G265V	ZFP28_uc002qni.2_Missense_Mutation_p.G265V|uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	265	KRAB 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		AGTGACCTGGGATCAGCAGGT	0.478000													5	9					3.59834e-05	3.78608e-05	1	0
ZNF835	90485	broad.mit.edu	37	19	57174961	57174961	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:57174961C>G	uc010ygo.1	-	2	1672	c.1672G>C	c.(1672-1674)GAA>CAA	p.E558Q	ZNF835_uc010ygn.1_Missense_Mutation_p.E536Q	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						TCTTAATCTTCTGCTGGTCCA	0.388000													27	31					0	0	0	0
ZIK1	284307	broad.mit.edu	37	19	58102361	58102361	+	Silent	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:58102361C>A	uc002qpg.2	+	4	1279	c.1182C>A	c.(1180-1182)CTC>CTA	p.L394L	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Silent_p.L339L|ZIK1_uc002qpi.2_Silent_p.L381L|ZIK1_uc002qpj.2_Silent_p.L291L	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	394	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAGCTACCCTCATTAAACACC	0.438000													26	43					1.85244e-09	2.0013e-09	1	0
A1BG	1	broad.mit.edu	37	19	58863922	58863922	+	Splice_Site	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr19:58863922C>T	uc002qsd.3	-	4	403	c.341_splice	c.e4-1	p.K114_splice	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_Splice_Site|NCRNA00181_uc002qsg.2_RNA	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor							extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		GGCAAGGACTCTGTGGGTGGG	0.602000													16	115					0	0	0	0
PRKD3	23683	broad.mit.edu	37	2	37501611	37501611	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:37501611G>A	uc002rqd.2	-	10	2159	c.1604C>T	c.(1603-1605)ACT>ATT	p.T535I	PRKD3_uc002rqe.1_Missense_Mutation_p.T135I|PRKD3_uc002rqf.1_Missense_Mutation_p.T535I	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	535					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				TGCTTGAGGAGTAACAGGCAT	0.453000													18	45					0	0	0	0
PLEK	5341	broad.mit.edu	37	2	68620335	68620335	+	Missense_Mutation	SNP	G	C	C	rs146499837		TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:68620335G>C	uc002sen.3	+	7	966	c.804G>C	c.(802-804)TTG>TTC	p.L268F	PLEK_uc010fde.2_Missense_Mutation_p.L268F	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	268	PH 2.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AGTTCATCTTGAGAGAAGACC	0.423000													45	130					0	0	0	0
BMP10	27302	broad.mit.edu	37	2	69093522	69093522	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:69093522C>T	uc002sez.1	-	2	675	c.516G>A	c.(514-516)GAG>GAA	p.E172E		NM_014482	NP_055297	O95393	BMP10_HUMAN	bone morphogenetic protein 10 preproprotein	172					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			ovary(2)	2						CCCCTTTGCTCTCCAGCACTT	0.448000													25	61					0	0	0	0
NAT8	9027	broad.mit.edu	37	2	73868736	73868737	+	Missense_Mutation	DNP	CG	GA	GA			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:73868736_73868737CG>GA	uc002sji.1	-	2	186_187	c.19_20CG>TC	c.(19-21)CGC>TCC	p.R7S		NM_003960	NP_003951	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8	7					gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			ovary(1)	1						CTGGTATTTGCGGATGTGACAA	0.589000													33	84					0	0	0	0
C2orf65	130951	broad.mit.edu	37	2	74785901	74785901	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:74785901G>A	uc002smy.2	-	11	1652	c.1535C>T	c.(1534-1536)TCT>TTT	p.S512F	C2orf65_uc010ysa.1_Missense_Mutation_p.S508F|C2orf65_uc010ffp.2_Missense_Mutation_p.S161F|C2orf65_uc002smx.2_Missense_Mutation_p.S264F	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	512					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						ATCTGAGGAAGATTTGCTGGC	0.587000													14	85					0	0	0	0
C2orf89	129293	broad.mit.edu	37	2	85097636	85097636	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:85097636C>G	uc010ysl.1	-	2	471	c.382G>C	c.(382-384)GAG>CAG	p.E128Q	C2orf89_uc002sou.3_Missense_Mutation_p.E128Q|C2orf89_uc010fgc.1_Missense_Mutation_p.E128Q	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	128	Extracellular (Potential).					integral to membrane				ovary(1)	1						TTGACATACTCCAGGTGGCGC	0.577000													15	39					0	0	0	0
IL1B	3553	broad.mit.edu	37	2	113591119	113591119	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:113591119C>A	uc002tii.1	-	4	220	c.133G>T	c.(133-135)GAT>TAT	p.D45Y	IL1B_uc002tih.1_Missense_Mutation_p.D14Y	NM_000576	NP_000567	P01584	IL1B_HUMAN	interleukin 1, beta proprotein	45					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			lung(3)|breast(1)	4					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	ATGCCGCCATCCAGAGGGCAG	0.602000													29	55					9.39395e-14	1.03805e-13	1	0
LCT	3938	broad.mit.edu	37	2	136579616	136579616	+	Silent	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:136579616C>A	uc002tuu.1	-	5	971	c.960G>T	c.(958-960)CTG>CTT	p.L320L	uc002tuv.1_RNA	NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	320	Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATGAACAACTCAGAAACTCAT	0.264000													13	31					1.05317e-09	1.1429e-09	1	0
ACVR1	90	broad.mit.edu	37	2	158617419	158617419	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:158617419C>G	uc002tzm.3	-	10	1576	c.1237G>C	c.(1237-1239)GAA>CAA	p.E413Q	ACVR1_uc002tzn.3_Missense_Mutation_p.E413Q|ACVR1_uc010fog.2_Missense_Mutation_p.E413Q	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	413	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	CTGGCCACTTCCCACAAAACA	0.433000													5	34					0	0	0	0
BAZ2B	29994	broad.mit.edu	37	2	160245956	160245956	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:160245956C>G	uc002uao.2	-	21	3468	c.3116G>C	c.(3115-3117)AGA>ACA	p.R1039T	BAZ2B_uc002uap.2_Missense_Mutation_p.R1003T	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1039	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TTTATTTAATCTTTTCTCATC	0.323000													23	56					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179579947	179579947	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:179579947T>C	uc010zfg.1	-	87	22458	c.22234A>G	c.(22234-22236)AAA>GAA	p.K7412E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K4073E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8339							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGCTCCTTTCAGTGTCTCT	0.398000													40	92					0	0	0	0
ANKAR	150709	broad.mit.edu	37	2	190571721	190571721	+	Silent	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:190571721A>G	uc002uqw.1	+	8	1755	c.1755A>G	c.(1753-1755)CAA>CAG	p.Q585Q	ANKAR_uc002uqu.2_RNA	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	656	ANK 4.					integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			ACACTATTCAATACCTGTTTT	0.353000													10	66					0	0	0	0
OSGEPL1	64172	broad.mit.edu	37	2	190617430	190617430	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:190617430C>T	uc002uqz.1	-	7	1649	c.1115G>A	c.(1114-1116)CGT>CAT	p.R372H	OSGEPL1_uc002ura.1_Intron	NM_022353	NP_071748	Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	372					proteolysis|tRNA processing		metalloendopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			CAAGCCAGCACGTAGTCTTTC	0.343000													28	59					0	0	0	0
ALS2CR8	79800	broad.mit.edu	37	2	203834680	203834680	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:203834680G>C	uc002uzo.2	+	10	1272	c.992G>C	c.(991-993)AGA>ACA	p.R331T	ALS2CR8_uc010zhz.1_RNA|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.R255T|ALS2CR8_uc010zib.1_Missense_Mutation_p.R255T|ALS2CR8_uc010zic.1_Missense_Mutation_p.R243T|ALS2CR8_uc002uzp.2_Missense_Mutation_p.R331T	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	331										large_intestine(1)|ovary(1)	2						CCTGAATATAGAGTTCCTACA	0.308000													15	22					0	0	0	0
ABCA12	26154	broad.mit.edu	37	2	215797408	215797408	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:215797408G>C	uc002vew.2	-	53	7958	c.7738C>G	c.(7738-7740)CAA>GAA	p.Q2580E	ABCA12_uc002vev.2_Missense_Mutation_p.Q2262E|ABCA12_uc010zjn.1_Missense_Mutation_p.Q1507E	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2580					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GTGGAACCTTGGCTGCTGGTA	0.423000													14	42					0	0	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32232451	32232451	+	Silent	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:32232451G>A	uc002wzg.1	+	12	2351	c.1814G>A	c.(1813-1815)TGA>TAA	p.*605*	CBFA2T2_uc010zug.1_Silent_p.*379*|CBFA2T2_uc002wze.1_Silent_p.*596*|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Silent_p.*576*|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA|CBFA2T2_uc002wzk.1_Silent_p.*153*	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	605						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						AACGGACTCTGAGCCCCGGAC	0.607000													33	99					0	0	0	0
EPB41L1	2036	broad.mit.edu	37	20	34761727	34761727	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:34761727G>A	uc002xfb.2	+	2	199	c.28G>A	c.(28-30)GAG>AAG	p.E10K	EPB41L1_uc002xeu.2_Intron|EPB41L1_uc010zvo.1_Missense_Mutation_p.E10K|EPB41L1_uc002xev.2_Missense_Mutation_p.E10K|EPB41L1_uc002xew.2_Intron|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Missense_Mutation_p.E10K|EPB41L1_uc002xez.2_Intron	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	10					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					CCCCGACTCTGAGGTGAAGAA	0.627000													20	69					0	0	0	0
RIMS4	140730	broad.mit.edu	37	20	43385614	43385614	+	Silent	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:43385614G>A	uc002xms.2	-	5	516	c.516C>T	c.(514-516)GTC>GTT	p.V172V	RIMS4_uc010ggu.2_Silent_p.V173V	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	172	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				ACTTGCGAGCGACTTTGGTCT	0.562000													117	361					0	0	0	0
ELMO2	63916	broad.mit.edu	37	20	44999107	44999107	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:44999107T>C	uc002xrt.1	-	20	2069	c.1859A>G	c.(1858-1860)GAG>GGG	p.E620G	ELMO2_uc010zxq.1_Missense_Mutation_p.E352G|ELMO2_uc002xrs.1_Missense_Mutation_p.E367G|ELMO2_uc002xru.1_Missense_Mutation_p.E620G|ELMO2_uc010zxr.1_Missense_Mutation_p.E632G|ELMO2_uc010zxs.1_Missense_Mutation_p.E437G|ELMO2_uc002xrv.1_Missense_Mutation_p.E339G	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	620	PH.				apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				AGCACTTTTCTCTTTCATGTG	0.458000													27	107					0	0	0	0
ITSN1	6453	broad.mit.edu	37	21	35208792	35208792	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr21:35208792G>C	uc002yta.1	+	29	3785	c.3517G>C	c.(3517-3519)GAG>CAG	p.E1173Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E1097Q|ITSN1_uc010gmg.2_Missense_Mutation_p.E1060Q|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E1173Q|ITSN1_uc010gmi.2_Missense_Mutation_p.E1136Q|ITSN1_uc010gmj.2_Missense_Mutation_p.E1052Q|ITSN1_uc002ysy.2_Missense_Mutation_p.E1168Q|ITSN1_uc002ysx.2_Missense_Mutation_p.E1131Q|ITSN1_uc002ytb.1_Missense_Mutation_p.E1168Q|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E1065Q|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E1168Q|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E1036Q|ITSN1_uc002yti.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1173	SH3 5.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						GAATGACGATGAGCTGGCCTT	0.572000													19	26					0	0	0	0
LOC96610	96610	broad.mit.edu	37	22	22661474	22661474	+	RNA	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr22:22661474C>T	uc011aim.1	+	28		c.1698C>T			LOC96610_uc011aiq.1_RNA|LOC96610_uc011aip.1_RNA|LOC96610_uc010gto.2_RNA					Parts of antibodies, mostly variable regions.												0						CCCTCAGATGCGTCTGAAGAA	0.493000													11	82					0	0	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659578	24659578	+	RNA	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr22:24659578A>G	uc002zzs.3	+	7		c.3310A>G			uc011ajp.1_5'Flank	NR_003714				Homo sapiens mRNA; cDNA DKFZp434P211 (from clone DKFZp434P211).												0						TGCGCAGGCCAACACTCACTG	0.617000													4	20					0	0	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659591	24659591	+	RNA	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr22:24659591A>G	uc002zzs.3	+	7		c.3323A>G			uc011ajp.1_5'Flank	NR_003714				Homo sapiens mRNA; cDNA DKFZp434P211 (from clone DKFZp434P211).												0						ACTCACTGACATCGAAGGCTG	0.632000													4	24					0	0	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659593	24659593	+	RNA	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr22:24659593C>T	uc002zzs.3	+	7		c.3325C>T			uc011ajp.1_5'Flank	NR_003714				Homo sapiens mRNA; cDNA DKFZp434P211 (from clone DKFZp434P211).												0						TCACTGACATCGAAGGCTGCC	0.632000													4	24					0	0	0	0
NPTXR	23467	broad.mit.edu	37	22	39222541	39222541	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr22:39222541C>T	uc003awk.2	-	3	1216	c.1062G>A	c.(1060-1062)GCG>GCA	p.A354A		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	354	Pentaxin.|Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					GCTCATGGCCCGCCTCTAGCA	0.667000													15	95					0	0	0	0
POLDIP3	84271	broad.mit.edu	37	22	42981957	42981957	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr22:42981957G>T	uc003bcu.2	-	9	1205	c.1106C>A	c.(1105-1107)CCA>CAA	p.P369Q	POLDIP3_uc011app.1_3'UTR|POLDIP3_uc003bcv.2_Missense_Mutation_p.P340Q|POLDIP3_uc011apq.1_Missense_Mutation_p.P386Q|POLDIP3_uc010gza.2_RNA|POLDIP3_uc011apr.1_RNA|POLDIP3_uc010gzb.1_Intron	NM_032311	NP_115687	Q9BY77	PDIP3_HUMAN	DNA polymerase delta interacting protein 3	369					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding				0						TTTCATTGATGGGCTGTCACT	0.488000													7	35					8.12818e-05	8.51524e-05	1	0
C3orf15	89876	broad.mit.edu	37	3	119462951	119462951	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr3:119462951G>A	uc003ede.3	+	14	1887	c.1810G>A	c.(1810-1812)GAG>AAG	p.E604K	C3orf15_uc010hqz.2_Missense_Mutation_p.E542K|C3orf15_uc011bjd.1_Missense_Mutation_p.E478K|C3orf15_uc011bje.1_Missense_Mutation_p.E584K	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	440						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		CATGCTGGCTGAGCGCCAGCG	0.572000													33	78					0	0	0	0
KALRN	8997	broad.mit.edu	37	3	124398320	124398320	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr3:124398320G>A	uc003ehg.2	+	51	7460	c.7333G>A	c.(7333-7335)GAG>AAG	p.E2445K	KALRN_uc003ehk.2_Missense_Mutation_p.E748K	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2444					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GAACAGTTCCGAGGAATCAGA	0.428000													38	122					0	0	0	0
HLTF	6596	broad.mit.edu	37	3	148781271	148781271	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr3:148781271G>C	uc003ewq.1	-	10	1325	c.1107C>G	c.(1105-1107)ATC>ATG	p.I369M	HLTF_uc003ewr.1_Missense_Mutation_p.I369M|HLTF_uc003ews.1_Missense_Mutation_p.I369M|HLTF_uc010hve.1_Missense_Mutation_p.I369M	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	369					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TCTTCTCCTTGATATCTGAAA	0.333000													25	61					0	0	0	0
TNIK	23043	broad.mit.edu	37	3	170786641	170786641	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr3:170786641G>T	uc003fhh.2	-	30	4040	c.3695C>A	c.(3694-3696)TCT>TAT	p.S1232Y	TNIK_uc003fhi.2_Missense_Mutation_p.S1177Y|TNIK_uc003fhj.2_Missense_Mutation_p.S1203Y|TNIK_uc003fhk.2_Missense_Mutation_p.S1224Y|TNIK_uc003fhl.2_Missense_Mutation_p.S1148Y|TNIK_uc003fhm.2_Missense_Mutation_p.S1169Y|TNIK_uc003fhn.2_Missense_Mutation_p.S1195Y|TNIK_uc003fho.2_Missense_Mutation_p.S1140Y|TNIK_uc003fhg.2_Missense_Mutation_p.S410Y|TNIK_uc003fhp.2_Missense_Mutation_p.S164Y	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1232	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			ACTTACATGAGATGGTATGTA	0.363000													8	46					0.000157383	0.000163462	1	0
GRK4	2868	broad.mit.edu	37	4	3021418	3021418	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:3021418C>T	uc003ggn.1	+	9	1247	c.792C>T	c.(790-792)CTC>CTT	p.L264L	GRK4_uc003ggo.1_Silent_p.L264L|GRK4_uc003ggp.1_Silent_p.L232L|GRK4_uc003ggq.1_Silent_p.L232L	NM_182982	NP_892027	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4 isoform	264	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCTTGGTGCTCACCATTATGA	0.433000													44	60					0	0	0	0
STX18	53407	broad.mit.edu	37	4	4458949	4458949	+	Silent	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:4458949G>T	uc003gic.2	-	5	550	c.466C>A	c.(466-468)CGA>AGA	p.R156R		NM_016930	NP_058626	Q9P2W9	STX18_HUMAN	syntaxin 18	156	Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|intracellular protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	SNAP receptor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.0534)		CTTTTAACTCGGATGGCTCTC	0.343000													7	26					3.09899e-07	3.31838e-07	1	0
BOD1L	259282	broad.mit.edu	37	4	13601055	13601055	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:13601055G>T	uc003gmz.1	-	10	7586	c.7469C>A	c.(7468-7470)TCA>TAA	p.S2490*	BOD1L_uc010idr.1_Nonsense_Mutation_p.S1827*	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2490							DNA binding			ovary(5)|breast(1)	6						CCTTCCTGCTGAATAACTTGC	0.507000											OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	49					1.61879e-10	1.77261e-10	1	0
UGT2A1	10941	broad.mit.edu	37	4	70512979	70512979	+	Silent	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:70512979G>A	uc003hem.3	-	1	447	c.384C>T	c.(382-384)GGC>GGT	p.G128G	UGT2A1_uc011caq.1_Silent_p.G128G|UGT2A1_uc010ihu.2_Silent_p.G128G|UGT2A1_uc010iht.2_Silent_p.G128G	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	128	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						TTTTAAGAACGCCATCACAGA	0.418000													19	36					0	0	0	0
CNOT6L	246175	broad.mit.edu	37	4	78641757	78641757	+	Missense_Mutation	SNP	T	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:78641757T>A	uc011ccd.1	-	12	1627	c.1496A>T	c.(1495-1497)AAC>ATC	p.N499I	CNOT6L_uc003hks.2_Missense_Mutation_p.N499I	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	499					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						ACCAAGCACGTTCATATGAGT	0.428000													40	131					0	0	0	0
EGF	1950	broad.mit.edu	37	4	110866313	110866313	+	Silent	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:110866313A>G	uc003hzy.3	+	5	1274	c.822A>G	c.(820-822)AAA>AAG	p.K274K	EGF_uc011cfu.1_Silent_p.K274K|EGF_uc011cfv.1_Silent_p.K274K	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	274	Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TAGCCAACAAACACACTGGAA	0.398000													7	23					0	0	0	0
DCHS2	54798	broad.mit.edu	37	4	155161884	155161884	+	Silent	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:155161884A>G	uc003inw.2	-	23	5799	c.5799T>C	c.(5797-5799)AAT>AAC	p.N1933N		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1933	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGGTTCCAGGATTACTCTCTT	0.383000													16	55					0	0	0	0
AHRR	57491	broad.mit.edu	37	5	422960	422960	+	Silent	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:422960G>A	uc003jav.2	+	6	614	c.570G>A	c.(568-570)CCG>CCA	p.P190P	AHRR_uc003jaw.2_Silent_p.P186P|AHRR_uc010isy.2_Silent_p.P36P|AHRR_uc010isz.2_Silent_p.P186P|AHRR_uc003jax.2_Intron|AHRR_uc003jay.2_Silent_p.P46P	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GGCAGCCCCCGCCCTTGGAGA	0.592000													6	47					0	0	0	0
SPEF2	79925	broad.mit.edu	37	5	35692806	35692806	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:35692806G>A	uc003jjo.2	+	12	1990	c.1879G>A	c.(1879-1881)GAG>AAG	p.E627K	SPEF2_uc003jjq.3_Missense_Mutation_p.E627K|SPEF2_uc003jjp.1_Missense_Mutation_p.E118K	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	627					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTTCTGCAAGAGGAGATTAA	0.393000													21	41					0	0	0	0
VCAN	1462	broad.mit.edu	37	5	82834175	82834175	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:82834175G>T	uc003kii.3	+	8	5709	c.5353G>T	c.(5353-5355)GAA>TAA	p.E1785*	VCAN_uc003kij.3_Nonsense_Mutation_p.E798*|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Nonsense_Mutation_p.E449*	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1785	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GTCTGAAAGGGAAATGACAGA	0.403000													27	24					2.24059e-21	2.55766e-21	1	0
RASA1	5921	broad.mit.edu	37	5	86675622	86675622	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:86675622C>G	uc003kiw.2	+	19	2676	c.2558C>G	c.(2557-2559)TCA>TGA	p.S853*	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Nonsense_Mutation_p.S676*|RASA1_uc011ctv.1_Nonsense_Mutation_p.S686*|RASA1_uc011ctw.1_Nonsense_Mutation_p.S687*|RASA1_uc010jaw.2_Nonsense_Mutation_p.S675*	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	853	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		AACATACTTTCAGAGCTTGTG	0.303000													14	17					0	0	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128984583	128984583	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:128984583G>C	uc003kvb.1	+	13	2078	c.2078G>C	c.(2077-2079)AGA>ACA	p.R693T	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	693	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CCTGGATTCAGAGACTGGCAA	0.448000													48	44					0	0	0	0
PCDHB9	56127	broad.mit.edu	37	5	140568765	140568765	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:140568765G>A	uc003liw.1	+	3	1874	c.1874G>A	c.(1873-1875)CGC>CAC	p.R625H		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	625	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGGAGGTGCGCACCGCCAGG	0.692000													35	36					0	0	0	0
RNF14	9604	broad.mit.edu	37	5	141358012	141358012	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:141358012C>T	uc003lly.2	+	4	490	c.451C>T	c.(451-453)CAG>TAG	p.Q151*	RNF14_uc003llz.2_Nonsense_Mutation_p.Q151*|RNF14_uc003lma.2_Nonsense_Mutation_p.Q151*|RNF14_uc003lmb.2_Nonsense_Mutation_p.Q25*|RNF14_uc003lmc.2_Nonsense_Mutation_p.Q151*|RNF14_uc011dbg.1_Intron|RNF14_uc011dbh.1_Intron|RNF14_uc003lmd.2_Nonsense_Mutation_p.Q151*	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	151					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GATTGGTTCTCAGAAAAAAGT	0.463000													11	11					0	0	0	0
RNF14	9604	broad.mit.edu	37	5	141358039	141358039	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:141358039C>G	uc003lly.2	+	4	517	c.478C>G	c.(478-480)CAA>GAA	p.Q160E	RNF14_uc003llz.2_Missense_Mutation_p.Q160E|RNF14_uc003lma.2_Missense_Mutation_p.Q160E|RNF14_uc003lmb.2_Missense_Mutation_p.Q34E|RNF14_uc003lmc.2_Missense_Mutation_p.Q160E|RNF14_uc011dbg.1_Intron|RNF14_uc011dbh.1_Intron|RNF14_uc003lmd.2_Missense_Mutation_p.Q160E	NM_183399	NP_899646	Q9UBS8	RNF14_HUMAN	ring finger protein 14 isoform 1	160					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding				0		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		AAGGACAGCTCAAGCTTCTCC	0.443000													6	15					0	0	0	0
Unknown	0	broad.mit.edu	37	5	164028158	164028158	+	RNA	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr5:164028158G>A	uc003lzn.2	+	3		c.336G>A								Homo sapiens, clone IMAGE:4479080, mRNA, partial cds.																		TGCCGTTGTAGACGCCCACCC	0.592000													11	6					0	0	0	0
HIST1H2BB	3018	broad.mit.edu	37	6	26043802	26043802	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:26043802C>G	uc003nfu.2	-	1	84	c.84G>C	c.(82-84)AAG>AAC	p.K28N	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	28					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCTTACGCTTCTTACCATCCT	0.507000													38	117					0	0	0	0
HIST1H3D	8351	broad.mit.edu	37	6	26197074	26197074	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:26197074C>A	uc003ngv.2	-	2	802	c.405G>T	c.(403-405)AGG>AGT	p.R135S	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	135				Missing (in Ref. 2; AAA52651).	blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				CAATTTACGCCCTCTCCCCAC	0.502000													28	40					7.26314e-15	8.17526e-15	1	0
DDR1	780	broad.mit.edu	37	6	30859860	30859860	+	Silent	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:30859860C>G	uc003nrr.2	+	8	1006	c.747C>G	c.(745-747)GTC>GTG	p.V249V	DDR1_uc010jse.2_Silent_p.V249V|DDR1_uc003nrq.2_Silent_p.V249V|DDR1_uc003nrs.2_Silent_p.V249V|DDR1_uc003nrt.2_Silent_p.V249V|DDR1_uc011dms.1_Silent_p.V267V|DDR1_uc003nru.2_Silent_p.V249V|DDR1_uc011dmu.1_Missense_Mutation_p.S216C|DDR1_uc003nrv.2_Silent_p.V249V|DDR1_uc003nrw.1_Silent_p.V48V|DDR1_uc003nry.1_5'Flank|DDR1_uc003nrx.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	249	Extracellular (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	AGCTGCGGGTCTGGCCAGGCT	0.577000													54	89					0	0	0	0
DDR1	780	broad.mit.edu	37	6	30860256	30860256	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:30860256C>T	uc003nrr.2	+	9	1295	c.1036C>T	c.(1036-1038)CTG>TTG	p.L346L	DDR1_uc010jse.2_Silent_p.L346L|DDR1_uc003nrq.2_Silent_p.L346L|DDR1_uc003nrs.2_Silent_p.L346L|DDR1_uc003nrt.2_Silent_p.L346L|DDR1_uc011dms.1_Silent_p.L364L|DDR1_uc003nru.2_Silent_p.L346L|DDR1_uc003nrv.2_Silent_p.L346L|DDR1_uc003nrw.1_Silent_p.L145L|DDR1_uc003nry.1_5'Flank|DDR1_uc003nrx.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	346	Extracellular (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	GGCTCGCTTTCTGCAGTGCCG	0.637000													35	33					0	0	0	0
DDR1	780	broad.mit.edu	37	6	30862324	30862324	+	Silent	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:30862324C>G	uc003nrr.2	+	12	1648	c.1389C>G	c.(1387-1389)CTC>CTG	p.L463L	DDR1_uc010jse.2_Silent_p.L463L|DDR1_uc003nrq.2_Silent_p.L463L|DDR1_uc003nrs.2_Silent_p.L463L|DDR1_uc003nrt.2_Silent_p.L463L|DDR1_uc011dms.1_Silent_p.L481L|DDR1_uc003nru.2_Silent_p.L463L|DDR1_uc003nrv.2_Silent_p.L463L|DDR1_uc003nrw.1_Intron|DDR1_uc003nry.1_RNA|DDR1_uc003nrx.1_Intron|DDR1_uc003nrz.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	463	Cytoplasmic (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	CGGTTCACCTCTCTGTCCCTG	0.587000													46	52					0	0	0	0
CCHCR1	54535	broad.mit.edu	37	6	31118878	31118878	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:31118878G>C	uc003nsr.3	-	5	679	c.556C>G	c.(556-558)CAC>GAC	p.H186D	CCHCR1_uc011dne.1_Missense_Mutation_p.H186D|CCHCR1_uc003nsq.3_Missense_Mutation_p.H239D|CCHCR1_uc003nsp.3_Missense_Mutation_p.H275D|CCHCR1_uc010jsk.1_Missense_Mutation_p.H186D	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	186	Potential.				cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						GCCTCCTCGTGAGCCTGTGTC	0.572000													41	146					0	0	0	0
MOCS1	4337	broad.mit.edu	37	6	39874211	39874211	+	Silent	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:39874211G>T	uc003opb.2	-	10	1971	c.1833C>A	c.(1831-1833)GTC>GTA	p.V611V	MOCS1_uc003opa.2_3'UTR|MOCS1_uc003opc.2_Silent_p.V595V|MOCS1_uc003opd.2_3'UTR|MOCS1_uc003ope.2_Silent_p.V508V	NM_005942	NP_005933	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis-step 1 protein	611	Molybdenum cofactor biosynthesis protein C.				Mo-molybdopterin cofactor biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			ovary(1)|liver(1)|central_nervous_system(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					TGTCCCTGCTGACAGCCTTGC	0.627000													72	96					3.61411e-23	4.16483e-23	1	0
CUL7	9820	broad.mit.edu	37	6	43007895	43007895	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:43007895C>G	uc003otq.2	-	22	4596	c.4293G>C	c.(4291-4293)AAG>AAC	p.K1431N	CUL7_uc010jyg.2_Missense_Mutation_p.K710N|CUL7_uc011dvb.1_Missense_Mutation_p.K1515N|CUL7_uc010jyh.2_Missense_Mutation_p.K424N|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1431					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GCTGCTCACTCTTGTTGTAGA	0.592000													23	112					0	0	0	0
CUL7	9820	broad.mit.edu	37	6	43008291	43008291	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:43008291C>T	uc003otq.2	-	21	4303	c.4000G>A	c.(4000-4002)GAG>AAG	p.E1334K	CUL7_uc010jyg.2_Missense_Mutation_p.E613K|CUL7_uc011dvb.1_Missense_Mutation_p.E1418K|CUL7_uc010jyh.2_Missense_Mutation_p.E327K|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1334					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TCTGTATCCTCCAGCTTCAGG	0.567000													57	187					0	0	0	0
SPATS1	221409	broad.mit.edu	37	6	44337822	44337822	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:44337822C>G	uc003oxk.2	+	6	1077	c.730C>G	c.(730-732)CCA>GCA	p.P244A	SPATS1_uc003oxg.2_RNA|SPATS1_uc010jzb.2_Missense_Mutation_p.P129A	NM_145026	NP_659463	Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	244										skin(1)	1	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TACATTTATTCCACTTGAGCC	0.323000													42	54					0	0	0	0
DST	667	broad.mit.edu	37	6	56338733	56338733	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:56338733C>T	uc003pdf.2	-	87	15603	c.15575G>A	c.(15574-15576)AGA>AAA	p.R5192K	DST_uc003pcz.3_Missense_Mutation_p.R5014K|DST_uc011dxj.1_Missense_Mutation_p.R5043K|DST_uc011dxk.1_Missense_Mutation_p.R5054K|DST_uc003pcy.3_Missense_Mutation_p.R4688K	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7100					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATCAGCAGCTCTCCTCTTATA	0.373000													11	5					0	0	0	0
ZUFSP	221302	broad.mit.edu	37	6	116968707	116968707	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:116968707C>G	uc003pxf.1	-	8	1629	c.1383G>C	c.(1381-1383)TGG>TGC	p.W461C	ZUFSP_uc010kef.1_Missense_Mutation_p.W265C	NM_145062	NP_659499	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	461						intracellular	zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		AGTTCAATATCCATTCAAATA	0.353000													21	54					0	0	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151161325	151161325	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:151161325C>T	uc003qny.1	+	17	3763	c.3451C>T	c.(3451-3453)CAG>TAG	p.Q1151*	PLEKHG1_uc011eem.1_Nonsense_Mutation_p.Q1210*	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	1151					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GGTAGTAAGTCAGCCCAACAA	0.522000													25	114					0	0	0	0
SERAC1	84947	broad.mit.edu	37	6	158535902	158535902	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:158535902G>A	uc003qrc.2	-	15	1745	c.1603C>T	c.(1603-1605)CAT>TAT	p.H535Y	SERAC1_uc003qrb.2_Missense_Mutation_p.H263Y	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	535					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		CGTGATCCATGATGAGGGACA	0.383000													62	110					0	0	0	0
TTLL2	83887	broad.mit.edu	37	6	167753771	167753771	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:167753771C>T	uc003qvs.1	+	3	471	c.383C>T	c.(382-384)TCC>TTC	p.S128F	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	128	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TGGAGGACATCCTCTTTCCGA	0.537000													5	24					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21847506	21847506	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:21847506A>G	uc003svc.2	+	64	10223	c.10192A>G	c.(10192-10194)ATT>GTT	p.I3398V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3398	Potential.|Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTCAGAGAAGATTCGCTGGGG	0.443000									Kartagener_syndrome				15	14					0	0	0	0
DFNA5	1687	broad.mit.edu	37	7	24784316	24784316	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:24784316C>A	uc010kus.1	-	3	357	c.269G>T	c.(268-270)GGA>GTA	p.G90V	DFNA5_uc003swz.2_5'UTR|DFNA5_uc003sxa.1_Missense_Mutation_p.G90V|DFNA5_uc010kut.1_5'UTR|DFNA5_uc003sxb.2_Missense_Mutation_p.G90V|DFNA5_uc003sxc.2_Missense_Mutation_p.G90V	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	90					sensory perception of sound					ovary(1)	1						CTCCAGGGTTCCACTCACGTG	0.562000													50	48					7.89702e-26	9.14392e-26	1	0
CYCS	54205	broad.mit.edu	37	7	25163649	25163649	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:25163649C>T	uc003sxl.2	-	2	235	c.90G>A	c.(88-90)GGG>GGA	p.G30G		NM_018947	NP_061820	P99999	CYC_HUMAN	cytochrome c	30					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis by intracellular signals|respiratory electron transport chain|transport	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nucleus|protein phosphatase type 2A complex|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding|protein binding			ovary(1)|lung(1)	2					Melatonin(DB01065)|Minocycline(DB01017)	GGAGATTTGGCCCAGTCTTGT	0.443000													4	86					0	0	0	0
POM121L12	285877	broad.mit.edu	37	7	53103452	53103453	+	Missense_Mutation	DNP	GC	AA	AA			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:53103452_53103453GC>AA	uc003tpz.2	+	1	104_105	c.88_89GC>AA	c.(88-90)GCG>AAG	p.A30K		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	30											0						CGACGCCCTGGCGGCTCCCATG	0.693000													13	42					0	0	0	0
POM121L12	285877	broad.mit.edu	37	7	53103987	53103987	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:53103987G>A	uc003tpz.2	+	1	639	c.623G>A	c.(622-624)CGG>CAG	p.R208Q		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	208											0						GGTGGCAGGCGGAACCTGCAG	0.667000													42	59					0	0	0	0
NCF1B	654816	broad.mit.edu	37	7	72640053	72640053	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:72640053G>A	uc011kes.1	+	3	288	c.284G>A	c.(283-285)CGC>CAC	p.R95H	FKBP6_uc003twz.2_Intron|NCF1B_uc011ker.1_Missense_Mutation_p.R97H	NM_000265	NP_000256			neutrophil cytosolic factor 1												0						TTCAAGGTGCGCCCTGATGAC	0.433000													15	13					0	0	0	0
MAGI2	9863	broad.mit.edu	37	7	78636436	78636436	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:78636436G>T	uc003ugx.2	-	2	642	c.388C>A	c.(388-390)CGT>AGT	p.R130S	MAGI2_uc003ugy.2_Missense_Mutation_p.R130S	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	130	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AGGTTGTCACGAATGATTTGC	0.363000													27	34					4.87955e-14	5.41675e-14	1	0
INTS10	55174	broad.mit.edu	37	8	19681434	19681434	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:19681434A>G	uc003wzj.2	+	7	846	c.715A>G	c.(715-717)AAG>GAG	p.K239E		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	239					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		TAGCTCTCAGAAGTACATAAT	0.398000													24	50					0	0	0	0
TRPA1	8989	broad.mit.edu	37	8	72958791	72958791	+	Missense_Mutation	SNP	G	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:72958791G>T	uc003xza.2	-	17	2193	c.2018C>A	c.(2017-2019)ACA>AAA	p.T673K	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	673	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CTGTGTAGGTGTTTTTTTGGT	0.269000													19	45					3.8784e-16	4.38586e-16	1	0
TRPA1	8989	broad.mit.edu	37	8	72958807	72958807	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:72958807C>G	uc003xza.2	-	17	2177	c.2002G>C	c.(2002-2004)GAA>CAA	p.E668Q	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	668	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TTGGTGAATTCTAATGGACAT	0.294000													11	38					0	0	0	0
FZD6	8323	broad.mit.edu	37	8	104343656	104343656	+	Silent	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:104343656C>G	uc003ylh.2	+	7	2324	c.2040C>G	c.(2038-2040)CTC>CTG	p.L680L	FZD6_uc003ylj.2_Silent_p.L680L|FZD6_uc011lhn.1_Silent_p.L646L|FZD6_uc011lho.1_Silent_p.L375L|FZD6_uc011lhp.1_Silent_p.L625L	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	680	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			CAAGCAGCCTCAAAGGTTCCA	0.448000													34	105					0	0	0	0
TRPS1	7227	broad.mit.edu	37	8	116631735	116631735	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:116631735G>C	uc003ynz.2	-	2	1010	c.551C>G	c.(550-552)TCA>TGA	p.S184*	TRPS1_uc011lhy.1_Nonsense_Mutation_p.S188*|TRPS1_uc003yny.2_Nonsense_Mutation_p.S197*|TRPS1_uc010mcy.2_Nonsense_Mutation_p.S184*	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	184					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TGGGTTTTTTGAGGCCACTGA	0.483000									Langer-Giedion_syndrome				21	139					0	0	0	0
PHF20L1	51105	broad.mit.edu	37	8	133837598	133837598	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:133837598A>G	uc003ytt.2	+	14	2051	c.1726A>G	c.(1726-1728)AAG>GAG	p.K576E	PHF20L1_uc011lja.1_Missense_Mutation_p.K550E|PHF20L1_uc003ytu.1_RNA	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	576	Lys-rich.						nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			aaaaaagaaaaagaaATCTAA	0.199000													7	0					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144995066	144995066	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144995066C>G	uc003zaf.1	-	32	9504	c.9334G>C	c.(9334-9336)GAG>CAG	p.E3112Q	PLEC_uc003zab.1_Missense_Mutation_p.E2975Q|PLEC_uc003zac.1_Missense_Mutation_p.E2979Q|PLEC_uc003zad.2_Missense_Mutation_p.E2975Q|PLEC_uc003zae.1_Missense_Mutation_p.E2943Q|PLEC_uc003zag.1_Missense_Mutation_p.E2953Q|PLEC_uc003zah.2_Missense_Mutation_p.E2961Q|PLEC_uc003zaj.2_Missense_Mutation_p.E3002Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3112	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCAGGCCCTCAAAGCAAAGC	0.647000													13	35					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144995127	144995127	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144995127C>G	uc003zaf.1	-	32	9443	c.9273G>C	c.(9271-9273)AAG>AAC	p.K3091N	PLEC_uc003zab.1_Missense_Mutation_p.K2954N|PLEC_uc003zac.1_Missense_Mutation_p.K2958N|PLEC_uc003zad.2_Missense_Mutation_p.K2954N|PLEC_uc003zae.1_Missense_Mutation_p.K2922N|PLEC_uc003zag.1_Missense_Mutation_p.K2932N|PLEC_uc003zah.2_Missense_Mutation_p.K2940N|PLEC_uc003zaj.2_Missense_Mutation_p.K2981N	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3091	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCTTGATGATCTTCTCCACTG	0.622000													17	53					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144995409	144995409	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144995409C>T	uc003zaf.1	-	32	9161	c.8991G>A	c.(8989-8991)GAG>GAA	p.E2997E	PLEC_uc003zab.1_Silent_p.E2860E|PLEC_uc003zac.1_Silent_p.E2864E|PLEC_uc003zad.2_Silent_p.E2860E|PLEC_uc003zae.1_Silent_p.E2828E|PLEC_uc003zag.1_Silent_p.E2838E|PLEC_uc003zah.2_Silent_p.E2846E|PLEC_uc003zaj.2_Silent_p.E2887E	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2997	Globular 2.|Plectin 5.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						ACGTGAGGTTCTCGTGCGTGT	0.657000													31	128					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144996152	144996152	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144996152C>G	uc003zaf.1	-	32	8418	c.8248G>C	c.(8248-8250)GAG>CAG	p.E2750Q	PLEC_uc003zab.1_Missense_Mutation_p.E2613Q|PLEC_uc003zac.1_Missense_Mutation_p.E2617Q|PLEC_uc003zad.2_Missense_Mutation_p.E2613Q|PLEC_uc003zae.1_Missense_Mutation_p.E2581Q|PLEC_uc003zag.1_Missense_Mutation_p.E2591Q|PLEC_uc003zah.2_Missense_Mutation_p.E2599Q|PLEC_uc003zaj.2_Missense_Mutation_p.E2640Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2750	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTGACCTCCTCTGAGTGCGCC	0.632000													4	45					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144996219	144996219	+	Silent	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144996219C>T	uc003zaf.1	-	32	8351	c.8181G>A	c.(8179-8181)GAG>GAA	p.E2727E	PLEC_uc003zab.1_Silent_p.E2590E|PLEC_uc003zac.1_Silent_p.E2594E|PLEC_uc003zad.2_Silent_p.E2590E|PLEC_uc003zae.1_Silent_p.E2558E|PLEC_uc003zag.1_Silent_p.E2568E|PLEC_uc003zah.2_Silent_p.E2576E|PLEC_uc003zaj.2_Silent_p.E2617E	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2727	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCCTCTGGTTCTCCTCAGCCA	0.547000													4	27					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144996395	144996395	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:144996395C>T	uc003zaf.1	-	32	8175	c.8005G>A	c.(8005-8007)GAG>AAG	p.E2669K	PLEC_uc003zab.1_Missense_Mutation_p.E2532K|PLEC_uc003zac.1_Missense_Mutation_p.E2536K|PLEC_uc003zad.2_Missense_Mutation_p.E2532K|PLEC_uc003zae.1_Missense_Mutation_p.E2500K|PLEC_uc003zag.1_Missense_Mutation_p.E2510K|PLEC_uc003zah.2_Missense_Mutation_p.E2518K|PLEC_uc003zaj.2_Missense_Mutation_p.E2559K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2669	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						tgctgctCCTCACGCAGCTGC	0.517000													9	8					0	0	0	0
SLC39A4	55630	broad.mit.edu	37	8	145638738	145638738	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:145638738C>T	uc003zcq.2	-	10	1610	c.1510G>A	c.(1510-1512)GAC>AAC	p.D504N	SLC39A4_uc003zcm.1_Missense_Mutation_p.D6N|SLC39A4_uc003zcn.2_Missense_Mutation_p.D6N|SLC39A4_uc003zco.2_Missense_Mutation_p.D228N|SLC39A4_uc003zcp.2_Missense_Mutation_p.D479N	NM_130849	NP_570901	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter),	504	Cytoplasmic (Potential).					cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			TGCACGGCGTCGCCCAGAGTG	0.697000													8	27					0	0	0	0
DDX58	23586	broad.mit.edu	37	9	32493813	32493813	+	Silent	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:32493813G>A	uc003zra.2	-	3	527	c.369C>T	c.(367-369)ATC>ATT	p.I123I	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Silent_p.I78I|DDX58_uc011lnr.1_5'UTR|DDX58_uc010mji.2_Silent_p.I52I	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	123	CARD 2.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		GATCAGAAATGATATCGGTTG	0.274000													26	23					0	0	0	0
GRIN3A	116443	broad.mit.edu	37	9	104499666	104499666	+	Missense_Mutation	SNP	A	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:104499666A>G	uc004bbp.1	-	1	1197	c.596T>C	c.(595-597)TTC>TCC	p.F199S	GRIN3A_uc004bbq.1_Missense_Mutation_p.F199S	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	199	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GCTCTGGGGGAAGGCGAGCAG	0.587000													3	100					0	0	0	0
RALGDS	5900	broad.mit.edu	37	9	136030585	136030585	+	Missense_Mutation	SNP	G	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:136030585G>A	uc011mcw.1	-	6	657	c.376C>T	c.(376-378)CAC>TAC	p.H126Y	GBGT1_uc004ccx.2_Silent_p.V66V|GBGT1_uc010nab.2_Missense_Mutation_p.H126Y|GBGT1_uc011mcx.1_Silent_p.V96V|GBGT1_uc004ccw.2_Silent_p.V113V|GBGT1_uc010nac.1_5'UTR|GBGT1_uc004ccy.1_Silent_p.V113V	NM_001042368	NP_001035827	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	Error:Variant_position_missing_in_Q12967_after_alignment					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CAAACACCGTGACCCCAATGG	0.587000			T	CIITA	PMBL|Hodgkin Lymphona|								35	56					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139400138	139400138	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:139400138C>T	uc004chz.2	-	25	4210	c.4210G>A	c.(4210-4212)GAG>AAG	p.E1404K	NOTCH1_uc004cia.1_Missense_Mutation_p.E634K	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1404	Extracellular (Potential).|EGF-like 36.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GATGTGGGCTCACAGGTCCCC	0.677000			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			35	49					0	0	0	0
ABCA2	20	broad.mit.edu	37	9	139910605	139910605	+	Missense_Mutation	SNP	G	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:139910605G>C	uc011mem.1	-	21	3271	c.3123C>G	c.(3121-3123)TTC>TTG	p.F1041L	ABCA2_uc011mel.1_Missense_Mutation_p.F1042L|ABCA2_uc004ckl.1_Missense_Mutation_p.F972L|ABCA2_uc004ckm.1_Missense_Mutation_p.F1072L|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1041	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		ACGTTGGAGGGAACAGGCCGG	0.652000													44	63					0	0	0	0
BEND2	139105	broad.mit.edu	37	X	18183158	18183158	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:18183158C>G	uc004cyj.3	-	14	2525	c.2371G>C	c.(2371-2373)GAT>CAT	p.D791H		NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	791										ovary(3)|kidney(1)|central_nervous_system(1)	5						GCGTCGGGATCTCCTGGCTTT	0.478000													64	43					0	0	0	0
ZNF182	7569	broad.mit.edu	37	X	47837109	47837109	+	Missense_Mutation	SNP	T	C	C			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:47837109T>C	uc004dir.2	-	7	723	c.377A>G	c.(376-378)AAG>AGG	p.K126R	ZNF182_uc004dis.2_Missense_Mutation_p.K107R|ZNF182_uc004dit.2_Missense_Mutation_p.K126R|ZNF182_uc011mlu.1_Missense_Mutation_p.K106R	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						AATTGTTTTCTTGTCAGAAAA	0.383000													14	8					0	0	0	0
HUWE1	10075	broad.mit.edu	37	X	53560308	53560308	+	Missense_Mutation	SNP	C	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:53560308C>A	uc004dsp.2	-	84	13489	c.13087G>T	c.(13087-13089)GCT>TCT	p.A4363S	HUWE1_uc004dsn.2_Missense_Mutation_p.A3171S	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4363	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCCTGGATAGCCAACAGTAGC	0.512000													8	5					0.000157383	0.000163462	1	0
HUWE1	10075	broad.mit.edu	37	X	53589155	53589155	+	Missense_Mutation	SNP	C	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:53589155C>T	uc004dsp.2	-	54	7657	c.7255G>A	c.(7255-7257)GAG>AAG	p.E2419K	HUWE1_uc004dsn.2_Missense_Mutation_p.E1243K	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2419	Glu-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CTGCTGTCCTCTTCCTGAGTG	0.403000													17	12					0	0	0	0
PCDH19	57526	broad.mit.edu	37	X	99657785	99657785	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:99657785C>G	uc010nmz.2	-	3	4029	c.2353G>C	c.(2353-2355)GAC>CAC	p.D785H	PCDH19_uc004efw.3_Missense_Mutation_p.D738H|PCDH19_uc004efx.3_Missense_Mutation_p.D738H	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	785	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						AGGCGGATGTCATTCTTACTG	0.448000													10	14					0	0	0	0
NKAP	79576	broad.mit.edu	37	X	119066103	119066103	+	Missense_Mutation	SNP	C	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:119066103C>G	uc004esh.2	-	6	981	c.814G>C	c.(814-816)GAG>CAG	p.E272Q	NKAP_uc004esg.2_Missense_Mutation_p.E159Q	NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	272	Necessary for interaction with CIR1.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						TCCAGAAACTCTTCTTGGGAT	0.353000													74	51					0	0	0	0
LRRC7	57554	broad.mit.edu	37	1	70504339	70504340	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:70504339_70504340insA	uc001dep.2	+	19	2748_2749	c.2718_2719insA	c.(2716-2721)AGTAATfs	p.S906fs	LRRC7_uc009wbg.2_Frame_Shift_Ins_p.S190fs|LRRC7_uc001deq.2_Frame_Shift_Ins_p.S147fs	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	906_907						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GGAGTCTTAGTAATGTCTTTTC	0.401													---	---	---							
TUFT1	7286	broad.mit.edu	37	1	151542192	151542206	+	In_Frame_Del	DEL	GGCCAAGCTTCAGGA	-	-	rs149655288		TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr1:151542192_151542206delGGCCAAGCTTCAGGA	uc001eyl.2	+	7	602_616	c.540_554delGGCCAAGCTTCAGGA	c.(538-555)CTGGCCAAGCTTCAGGAG>CTG	p.AKLQE181del	TUFT1_uc001eym.2_In_Frame_Del_p.AKLQE156del|TUFT1_uc010pdf.1_In_Frame_Del_p.AKLQE200del|TUFT1_uc010pdg.1_In_Frame_Del_p.AKLQE129del	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1	181_185	Potential.				bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGGACTTGCTGGCCAAGCTTCAGGAGGCCAAGCGG	0.540													---	---	---							
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	-	-	rs3812754	byFrequency	TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr11:12316384_12316389delCTCCTA	uc001mkg.1	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)CCTCCTACA>CCA	p.PT470del		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	470_471					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		cctcctcctcctcctACAGCGGGAGG	0.432													---	---	---							
MTHFD1	4522	broad.mit.edu	37	14	64906869	64906879	+	Frame_Shift_Del	DEL	GTGAAATTATG	-	-			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr14:64906869_64906879delGTGAAATTATG	uc001xhb.2	+	18	2087_2097	c.1700_1710delGTGAAATTATG	c.(1699-1710)AGTGAAATTATGfs	p.S567fs	MTHFD1_uc010aqe.2_Frame_Shift_Del_p.S603fs|MTHFD1_uc010aqf.2_Frame_Shift_Del_p.S623fs	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	567_570	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TCTGTGGCCAGTGAAATTATGGCTGTCCTGG	0.479													---	---	---							
TNRC6A	27327	broad.mit.edu	37	16	24802886	24802887	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:24802886_24802887insT	uc002dmm.2	+	6	3037_3038	c.2923_2924insT	c.(2923-2925)ATAfs	p.I975fs	TNRC6A_uc010bxs.2_Frame_Shift_Ins_p.I722fs|TNRC6A_uc010vcc.1_Frame_Shift_Ins_p.I722fs|TNRC6A_uc002dmn.2_Frame_Shift_Ins_p.I722fs|TNRC6A_uc002dmo.2_Frame_Shift_Ins_p.I722fs	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	975	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GGGGGGACCTATACCAGCCCCA	0.525													---	---	---							
Unknown	0	broad.mit.edu	37	16	86093765	86093766	+	IGR	INS	-	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr16:86093765_86093766insG								IRF8 (137556 upstream) : LOC732275 (271690 downstream)																							GGCCCAGAGCCGGCCTTCCCTC	0.594													---	---	---							
Unknown	0	broad.mit.edu	37	2	81424064	81424065	+	IGR	INS	-	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr2:81424064_81424065insG								CTNNA2 (548160 upstream) : None (None downstream)																							GGAGCCTGGCTGGCGTTTTCCA	0.569													---	---	---							
RALGAPA2	57186	broad.mit.edu	37	20	20621406	20621407	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:20621406_20621407insA	uc002wrz.2	-	6	631_632	c.488_489insT	c.(487-489)ATGfs	p.M163fs	RALGAPA2_uc010zsg.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	163					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						CCCTGGATGACATGACTGCTGG	0.485													---	---	---							
NCOA3	8202	broad.mit.edu	37	20	46279864	46279866	+	In_Frame_Del	DEL	CAA	-	-	rs67218125		TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr20:46279864_46279866delCAA	uc002xtk.2	+	20	3995_3997	c.3790_3792delCAA	c.(3790-3792)CAAdel	p.Q1276del	NCOA3_uc010ght.1_In_Frame_Del_p.Q1267del|NCOA3_uc002xtl.2_In_Frame_Del_p.Q1272del|NCOA3_uc002xtm.2_In_Frame_Del_p.Q1271del|NCOA3_uc002xtn.2_In_Frame_Del_p.Q1275del|NCOA3_uc010zyc.1_In_Frame_Del_p.Q1071del	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1276	Poly-Gln.|Acetyltransferase.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						gcagcagcagcaacagcaacagc	0.310													---	---	---							
NCAPG	64151	broad.mit.edu	37	4	17841312	17841313	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:17841312_17841313insT	uc003gpp.2	+	17	2656_2657	c.2480_2481insT	c.(2479-2481)CATfs	p.H827fs	NCAPG_uc011bxj.1_Frame_Shift_Ins_p.H336fs	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	827					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		TTAACAGTACATGACAATTTGG	0.312													---	---	---							
PET112L	5188	broad.mit.edu	37	4	152593929	152593930	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr4:152593929_152593930insT	uc003iml.2	-	12	1541_1542	c.1529_1530insA	c.(1528-1530)GAGfs	p.E510fs	PET112L_uc003imk.2_RNA	NM_004564	NP_004555	O75879	GATB_HUMAN	PET112-like precursor	510						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding				0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)			L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAGGATGGGCCTCCATCACAGA	0.609													---	---	---							
DDX43	55510	broad.mit.edu	37	6	74114465	74114466	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr6:74114465_74114466insA	uc003pgw.2	+	5	965_966	c.621_622insA	c.(619-624)GCCATGfs	p.A207fs	DDX43_uc011dyn.1_Intron	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	207_208						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						CCACAAGTGCCATGTCAAAAGT	0.361													---	---	---							
Unknown	0	broad.mit.edu	37	7	64975077	64975078	+	IGR	INS	-	AGAT	AGAT			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr7:64975077_64975078insAGAT								ZNF92 (109080 upstream) : INTS4L2 (137699 downstream)																							AGTGCACCCGAAAACAAAGATG	0.455													---	---	---							
PKHD1L1	93035	broad.mit.edu	37	8	110455173	110455174	+	Splice_Site	INS	-	G	G			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr8:110455173_110455174insG	uc003yne.2	+	36	4498	c.4394_splice	c.e36-1	p.G1465_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTTATGGCAGGTTCATTTTC	0.322										HNSCC(38;0.096)			---	---	---							
ACO1	48	broad.mit.edu	37	9	32448900	32448900	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:32448900delA	uc003zqw.3	+	20	2532	c.2377delA	c.(2377-2379)AAAfs	p.K793fs	ACO1_uc003zqx.3_Frame_Shift_Del_p.K793fs|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	793					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TCAGGGAATCAAAGCCGTCCT	0.448													---	---	---							
NOTCH1	4851	broad.mit.edu	37	9	139410477	139410477	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chr9:139410477delT	uc004chz.2	-	10	1625	c.1625delA	c.(1624-1626)AAGfs	p.K542fs	NOTCH1_uc004cia.1_5'Flank	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	542	Extracellular (Potential).|EGF-like 14; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTCCAGGCACTTGGCACCATT	0.667			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---							
FLNA	2316	broad.mit.edu	37	X	153580304	153580305	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-CR-7365-01A-11D-2012-08	TCGA-CR-7365-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	ec114413-a950-4e74-abc8-98857af8b9ad	247b7339-48fe-485b-8266-1e8488d1527d	g.chrX:153580304_153580305delAA	uc004fkk.2	-	42	7103_7104	c.6854_6855delTT	c.(6853-6855)TTTfs	p.F2285fs	FLNA_uc004fki.2_Frame_Shift_Del_p.F328fs|FLNA_uc011mzn.1_Frame_Shift_Del_p.F418fs|FLNA_uc010nuu.1_Frame_Shift_Del_p.F2277fs	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2285	Filamin 21.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGCGGTCCTCAAAAGAGATCTC	0.619													---	---	---							
