Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SCNN1D	6339	broad.mit.edu	37	1	1221451	1221451	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:1221451G>A	uc001adu.1	+	6	836	c.212G>A	c.(211-213)GGC>GAC	p.G71D	SCNN1D_uc001adt.1_Missense_Mutation_p.G235D|SCNN1D_uc001adw.2_Missense_Mutation_p.G137D|SCNN1D_uc001adx.2_5'UTR|SCNN1D_uc001adv.2_Missense_Mutation_p.G71D	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		ACCATCCACGGCGCCATCCGC	0.662000													6	7					0	0	0.001168	0	0
RERE	473	broad.mit.edu	37	1	8420609	8420609	+	Silent	SNP	T	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:8420609T>G	uc001ape.2	-	19	3768	c.2958A>C	c.(2956-2958)CCA>CCC	p.P986P	RERE_uc001apf.2_Silent_p.P986P|RERE_uc010nzx.1_Silent_p.P718P|RERE_uc001apd.2_Silent_p.P432P	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	986	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GTTGCAGGGGTGGGGGGTGAG	0.706000													4	32					0	0	0.001984	0	0
MST1P9	11223	broad.mit.edu	37	1	17084510	17084510	+	Silent	SNP	G	A	A	rs61769731	by1000genomes	TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:17084510G>A	uc010ock.1	-	12	1588	c.1588C>T	c.(1588-1590)CTA>TTA	p.L530L	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_Silent_p.L130L	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						ACCCGCTGTAGGCCTGGCTCT	0.577000													14	88					0	0	0.001855	0	0
CROCC	9696	broad.mit.edu	37	1	17256819	17256819	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:17256819C>T	uc001azt.2	+	6	729	c.660C>T	c.(658-660)ATC>ATT	p.I220I	CROCC_uc009voy.1_5'UTR|CROCC_uc009voz.1_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	220	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCGCCCTCATCCGGCTGGAGG	0.677000													6	15					0	0	0.001984	0	0
PADI4	23569	broad.mit.edu	37	1	17657557	17657557	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:17657557C>T	uc001baj.2	+	2	214	c.186C>T	c.(184-186)TCC>TCT	p.S62S	PADI4_uc009vpc.2_Silent_p.S62S	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	62					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	AGAAGAAATCCACAGGTTCCT	0.602000													27	29					0	0	0.008361	0	0
CATSPER4	378807	broad.mit.edu	37	1	26524784	26524784	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:26524784C>T	uc010oez.1	+	6	686	c.686C>T	c.(685-687)TCC>TTC	p.S229F	CATSPER4_uc010oey.1_Missense_Mutation_p.S51F|CATSPER4_uc009vsf.2_Intron	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	229	Helical; Name=Segment S5; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGTTTTTTCCGTGTTTGGA	0.493000													72	328					0	0	0.003610	0	0
ARID1A	8289	broad.mit.edu	37	1	27100919	27100919	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:27100919C>T	uc001bmv.1	+	18	4574	c.4201C>T	c.(4201-4203)CAG>TAG	p.Q1401*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1400*|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q1018*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q247*|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1401	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Q1401*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGGGCAGCCTCAGCAGCAGCA	0.607000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								10	41					0	0	0.008291	0	0
ARID1A	8289	broad.mit.edu	37	1	27106861	27106861	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:27106861C>T	uc001bmv.1	+	20	6845	c.6472C>T	c.(6472-6474)CGA>TGA	p.R2158*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.R1941*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.R1004*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.R486*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.R400*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2158					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.R2158*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCTCAGTGACCGAAAGAACCC	0.597000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								35	59					0	0	0.003271	0	0
C1orf172	126695	broad.mit.edu	37	1	27278858	27278858	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:27278858C>T	uc001bni.1	-	2	103	c.14G>A	c.(13-15)GGA>GAA	p.G5E		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	5	Pro-rich.									large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GCGGGGGTGTCCAGGGCGGGG	0.617000													39	55					0	0	0.006999	0	0
SESN2	83667	broad.mit.edu	37	1	28605701	28605701	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:28605701C>T	uc001bps.2	+	9	1658	c.1305C>T	c.(1303-1305)ACC>ACT	p.T435T		NM_031459	NP_113647	P58004	SESN2_HUMAN	sestrin 2	435					cell cycle arrest	cytoplasm|nucleus				skin(3)|ovary(2)|pancreas(1)|lung(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		CAGAGAAGACCACCCGAAGAA	0.512000													19	51					0	0	0.008871	0	0
COL9A2	1298	broad.mit.edu	37	1	40777385	40777385	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:40777385C>T	uc001cfh.1	-	9	490	c.420G>A	c.(418-420)GGG>GGA	p.G140G	COL9A2_uc001cfi.1_5'UTR	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	140	Triple-helical region 4 (COL4).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			GTCCAGGGTCCCCCTGGAAGC	0.617000													38	53					0	0	0.004878	0	0
STIL	6491	broad.mit.edu	37	1	47735459	47735459	+	Silent	SNP	G	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:47735459G>T	uc001crc.1	-	14	2618	c.2463C>A	c.(2461-2463)TCC>TCA	p.S821S	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Silent_p.S774S|STIL_uc010omo.1_Silent_p.S821S|STIL_uc001crd.1_Silent_p.S821S|STIL_uc001cre.1_Silent_p.S821S|STIL_uc001crf.1_Silent_p.S434S|STIL_uc001crg.1_Silent_p.S774S	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	821					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TGTCCTCACTGGAAATTTTGG	0.378000													11	55					6.40141e-05	6.84595e-05	0.000978	1	0
FAF1	11124	broad.mit.edu	37	1	51204578	51204578	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:51204578G>A	uc009vyx.1	-	7	571	c.508C>T	c.(508-510)CTT>TTT	p.L170F	FAF1_uc009vyw.1_RNA|FAF1_uc001cse.1_Missense_Mutation_p.L170F	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	170					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(1)		ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		TCTGGTGTAAGGACATAAAGA	0.343000													7	23					0	0	0.004482	0	0
ACOT11	26027	broad.mit.edu	37	1	55062987	55062987	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:55062987G>A	uc001cxm.1	+	7	745	c.663G>A	c.(661-663)GAG>GAA	p.E221E	ACOT11_uc001cxj.1_Silent_p.E99E|ACOT11_uc001cxk.2_Silent_p.E187E|ACOT11_uc001cxl.1_Silent_p.E221E	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	221	Acyl coenzyme A hydrolase 2.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						CCCGTGTGGAGAGTGTGGAGC	0.602000													20	19					0	0	0.008871	0	0
GBP6	163351	broad.mit.edu	37	1	89844118	89844118	+	Missense_Mutation	SNP	G	A	A	rs144008165		TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:89844118G>A	uc001dnf.2	+	5	845	c.571G>A	c.(571-573)GGT>AGT	p.G191S	GBP6_uc010ost.1_Missense_Mutation_p.G61S	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	191							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		GAAGTTGAACGGTCACCCTAT	0.493000													24	79					0	0	0.003954	0	0
DPYD	1806	broad.mit.edu	37	1	97981298	97981298	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:97981298G>A	uc001drv.2	-	13	1861	c.1724C>T	c.(1723-1725)ACT>ATT	p.T575I		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	575					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AAGAGAGAAAGTTTTGGTGAG	0.328000													12	23					0	0	0.001368	0	0
KCNN3	3782	broad.mit.edu	37	1	154698427	154698427	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:154698427G>A	uc001ffp.2	-	5	1980	c.1666C>T	c.(1666-1668)CAT>TAT	p.H556Y	KCNN3_uc001ffo.2_Missense_Mutation_p.H251Y	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	561						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			ATGAAGTTATGAACGTGCTTC	0.567000													17	16					0	0	0.007413	0	0
CCT3	7203	broad.mit.edu	37	1	156303399	156303399	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:156303399G>A	uc001fol.1	-	5	463	c.243C>T	c.(241-243)ATC>ATT	p.I81I	CCT3_uc001fom.1_Silent_p.I81I|CCT3_uc001fon.1_Silent_p.I43I|CCT3_uc010phj.1_Silent_p.I35I|CCT3_uc010phk.1_Silent_p.I35I|CCT3_uc010phl.1_Silent_p.I35I	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	81					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					GGCTAATTTCGATCATGGACT	0.423000													21	78					0	0	0.004656	0	0
FCRL2	79368	broad.mit.edu	37	1	157745580	157745580	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:157745580C>T	uc001fre.2	-	2	96	c.37G>A	c.(37-39)GTC>ATC	p.V13I	FCRL2_uc010phz.1_Missense_Mutation_p.V13I|FCRL2_uc009wsp.2_Missense_Mutation_p.V13I|FCRL2_uc010pia.1_Missense_Mutation_p.V13I	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	13					cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGTTCAGTGACTGCATCTGTG	0.428000													13	27					0	0	0.004007	0	0
OR10J1	26476	broad.mit.edu	37	1	159410425	159410425	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:159410425C>T	uc010piv.1	+	1	877	c.877C>T	c.(877-879)CCC>TCC	p.P293S	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	293	Helical; Name=7; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					TGTCATCACTCCCCTACTGAA	0.507000													15	57					0	0	0.002450	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161019438	161019438	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:161019438C>T	uc001fxl.2	-	11	1808	c.1462G>A	c.(1462-1464)GAC>AAC	p.D488N	ARHGAP30_uc001fxk.2_Missense_Mutation_p.D488N|ARHGAP30_uc001fxm.2_Missense_Mutation_p.D334N|ARHGAP30_uc009wtx.2_Missense_Mutation_p.D161N|ARHGAP30_uc001fxn.1_Missense_Mutation_p.D334N	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	488					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GGGCCTGAGTCTGCCAGGGGA	0.562000													18	75					0	0	0.007413	0	0
FAM5B	57795	broad.mit.edu	37	1	177242650	177242650	+	Silent	SNP	G	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:177242650G>T	uc001glf.2	+	5	1008	c.696G>T	c.(694-696)CTG>CTT	p.L232L	FAM5B_uc010pna.1_5'UTR|FAM5B_uc001glg.2_Silent_p.L127L	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	232						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CCGGTCCTCTGGGCTGCAGCA	0.488000													18	37					1.01871e-10	1.11739e-10	0.008871	1	0
NR5A2	2494	broad.mit.edu	37	1	200089940	200089940	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:200089940A>G	uc001gvb.2	+	7	1441	c.1235A>G	c.(1234-1236)GAC>GGC	p.D412G	NR5A2_uc001gvc.2_Missense_Mutation_p.D366G|NR5A2_uc009wzh.2_Missense_Mutation_p.D372G|NR5A2_uc010pph.1_Missense_Mutation_p.D340G	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	412					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					TTGCAGGTGGACTATTCCATA	0.413000													16	27					0	0	0.004007	0	0
LGR6	59352	broad.mit.edu	37	1	202288196	202288196	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:202288196G>A	uc001gxu.2	+	18	2765	c.2765G>A	c.(2764-2766)GGG>GAG	p.G922E	LGR6_uc001gxv.2_Missense_Mutation_p.G870E|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.G783E	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	922	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						GAGCCAGAGGGGAACCACTTT	0.642000													31	38					0	0	0.009535	0	0
ZNF238	10472	broad.mit.edu	37	1	244218069	244218069	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:244218069C>T	uc001iae.2	+	1	1488	c.966C>T	c.(964-966)GTC>GTT	p.V322V	ZNF238_uc001iad.3_Silent_p.V331V|ZNF238_uc001iaf.1_3'UTR	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	322	Interaction with DNMT3A.				negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			AGGACTCGGTCTTGAGGGAGC	0.557000													30	26					0	0	0.002096	0	0
C1orf150	148823	broad.mit.edu	37	1	247737636	247737636	+	Silent	SNP	T	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:247737636T>C	uc001idf.2	+	5	405	c.360T>C	c.(358-360)CCT>CCC	p.P120P	C1orf150_uc009xgw.2_RNA|C1orf150_uc001ida.3_RNA|C1orf150_uc001idb.3_RNA|C1orf150_uc009xgx.2_RNA	NM_145278	NP_660321	Q5JQS6	CA150_HUMAN	hypothetical protein LOC148823	120											0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TTAGTAGGCCTTGTTCCTGCA	0.428000													12	31					0	0	0.001368	0	0
PLXDC2	84898	broad.mit.edu	37	10	20453447	20453447	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr10:20453447C>T	uc001iqg.1	+	7	1471	c.834C>T	c.(832-834)GTC>GTT	p.V278V	PLXDC2_uc001iqh.1_Silent_p.V229V|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	278	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						CAGTGAAAGTCGGACTGTCCG	0.428000													10	9					0	0	0.001855	0	0
ZNF33B	7582	broad.mit.edu	37	10	43088258	43088258	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr10:43088258C>T	uc001jaf.1	-	5	2255	c.2140G>A	c.(2140-2142)GCT>ACT	p.A714T	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.A602T|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	714	C2H2-type 14.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCTGTGTGAGCCCTGTGATGT	0.403000													40	32					0	0	0.006999	0	0
ZNF365	22891	broad.mit.edu	37	10	64136385	64136385	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr10:64136385G>A	uc001jmc.2	+	2	748	c.433G>A	c.(433-435)GGT>AGT	p.G145S	ZNF365_uc001jly.3_Missense_Mutation_p.G160S|ZNF365_uc001jmb.3_Missense_Mutation_p.G145S|ZNF365_uc001jlz.3_Missense_Mutation_p.G145S|ZNF365_uc001jma.3_Intron	NM_199451	NP_955523	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform C	204										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GACACGGTCGGGTCCTGGACT	0.537000													30	21					0	0	0.008361	0	0
MYOF	26509	broad.mit.edu	37	10	95111307	95111307	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr10:95111307G>A	uc001kin.2	-	34	3808	c.3685C>T	c.(3685-3687)CGA>TGA	p.R1229*	MYOF_uc001kio.2_Nonsense_Mutation_p.R1216*|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1229	Cytoplasmic (Potential).|C2 4.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						AAAATGCTTCGTCCTAAAAAT	0.428000													6	70					0	0	0.001168	0	0
VWA2	340706	broad.mit.edu	37	10	116049010	116049010	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr10:116049010C>T	uc001lbl.1	+	12	2205	c.1884C>T	c.(1882-1884)GCC>GCT	p.A628A	VWA2_uc001lbk.1_Silent_p.A628A|VWA2_uc009xyf.1_Silent_p.A324A	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	628	VWFA 3.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		AGAGGGGTGCCCGGCCTGGTG	0.642000													18	11					0	0	0.007413	0	0
KCNK18	338567	broad.mit.edu	37	10	118969366	118969366	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr10:118969366G>A	uc010qsr.1	+	3	711	c.711G>A	c.(709-711)CAG>CAA	p.Q237Q		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	237	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		TAGAGAAACAGAACACACTGC	0.532000													34	34					0	0	0.002836	0	0
ZNF195	7748	broad.mit.edu	37	11	3381179	3381179	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:3381179G>A	uc001lxt.2	-	6	1237	c.1059C>T	c.(1057-1059)CCC>CCT	p.P353P	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Silent_p.P330P|ZNF195_uc001lxs.2_Silent_p.P281P|ZNF195_uc010qxr.1_Silent_p.P334P|ZNF195_uc009ydz.2_Silent_p.P308P|ZNF195_uc001lxu.2_Silent_p.P285P	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	353				Missing (in Ref. 2; BAD18466).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		CATATTTGCAGGGTTTTTCCT	0.418000													49	99					0	0	0.003610	0	0
OR51B4	79339	broad.mit.edu	37	11	5322610	5322610	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:5322610G>A	uc010qza.1	-	1	567	c.567C>T	c.(565-567)ATC>ATT	p.I189I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033179	NP_149419	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATTAAACGTGATATCAGCAC	0.373000													24	47					0	0	0.005443	0	0
TUB	7275	broad.mit.edu	37	11	8111659	8111659	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:8111659C>T	uc001mga.2	+	3	283	c.134C>T	c.(133-135)CCC>CTC	p.P45L	TUB_uc010rbk.1_Missense_Mutation_p.P51L|TUB_uc001mfy.2_Missense_Mutation_p.P100L	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	45					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		CGCCAGGAGCCCCTGATGGTG	0.542000													13	10					0	0	0.002450	0	0
SPON1	10418	broad.mit.edu	37	11	14284295	14284295	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:14284295G>A	uc001mle.2	+	16	2572	c.2034G>A	c.(2032-2034)TCG>TCA	p.S678S		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	678	TSP type-1 5.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		CCCAGTGGTCGGAATGTAACA	0.522000													18	33					0	0	0.007413	0	0
INSC	387755	broad.mit.edu	37	11	15247312	15247312	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:15247312C>T	uc001mly.2	+	9	1295	c.1249C>T	c.(1249-1251)CGT>TGT	p.R417C	INSC_uc001mlz.2_Missense_Mutation_p.R370C|INSC_uc001mma.2_Missense_Mutation_p.R370C|INSC_uc010rcs.1_Missense_Mutation_p.R405C|INSC_uc001mmb.2_Missense_Mutation_p.R370C|INSC_uc001mmc.2_Missense_Mutation_p.R328C	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	417					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						GAATGCCATCCGTGTTCTCCT	0.572000													7	26					0	0	0.001984	0	0
DBX1	120237	broad.mit.edu	37	11	20177834	20177834	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:20177834C>T	uc001mpw.1	-	4	1075	c.1075G>A	c.(1075-1077)GGG>AGG	p.G359R		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	320					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GAAGGTTTCCCGGGACTGCTC	0.677000													99	85					0	0	0.003610	0	0
GAS2	2620	broad.mit.edu	37	11	22707235	22707235	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:22707235C>G	uc009yie.2	+	3	473	c.167C>G	c.(166-168)ACT>AGT	p.T56S	GAS2_uc001mqm.2_Missense_Mutation_p.T56S|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Missense_Mutation_p.T56S	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	56	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						ACAGCAGAAACTTTTATGGAG	0.363000													28	55					0	0	0.009535	0	0
CCDC73	493860	broad.mit.edu	37	11	32636347	32636347	+	Missense_Mutation	SNP	G	A	A	rs79335956		TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:32636347G>A	uc001mtv.2	-	16	1561	c.1517C>T	c.(1516-1518)ACG>ATG	p.T506M		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	506										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TCTGTTGTCCGTAACATTCGA	0.323000													8	133					0	0	0.003080	0	0
CKAP5	9793	broad.mit.edu	37	11	46801774	46801774	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:46801774G>A	uc001ndi.1	-	20	2513	c.2403C>T	c.(2401-2403)CTC>CTT	p.L801L	CKAP5_uc009ylg.1_Silent_p.L687L|CKAP5_uc001ndj.1_Silent_p.L801L	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	801					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TCTGGGATAGGAGGGCAGGCT	0.433000													18	29					0	0	0.008871	0	0
OR4C15	81309	broad.mit.edu	37	11	55321940	55321940	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:55321940G>A	uc010rig.1	+	1	158	c.158G>A	c.(157-159)GGA>GAA	p.G53E		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	Error:Variant_position_missing_in_Q8NGM1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTTTCCTTGGGAAACATGCAA	0.358000										HNSCC(20;0.049)			41	114					0	0	0.002522	0	0
OR5D13	390142	broad.mit.edu	37	11	55541346	55541346	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:55541346C>T	uc010ril.1	+	1	433	c.433C>T	c.(433-435)CTT>TTT	p.L145F		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				GCTCTGTGCTCTTCTGGTGGC	0.418000													82	186					0	0	0.003610	0	0
OR8H1	219469	broad.mit.edu	37	11	56058493	56058493	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:56058493C>T	uc010rje.1	-	1	46	c.46G>A	c.(46-48)GGA>AGA	p.G16R		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					TCTGACAGTCCCGTAAGGATG	0.378000													36	77					0	0	0.003755	0	0
OR5M1	390168	broad.mit.edu	37	11	56380097	56380097	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:56380097G>C	uc001nja.1	-	1	882	c.882C>G	c.(880-882)AAC>AAG	p.N294K		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TTACATCTGTGTTCCGTAGGC	0.403000													30	225					0	0	0.002836	0	0
ZDHHC5	25921	broad.mit.edu	37	11	57450009	57450009	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:57450009C>T	uc001nkx.1	+	3	1476	c.220C>T	c.(220-222)CCT>TCT	p.P74S	ZDHHC5_uc001nky.1_Missense_Mutation_p.P21S|ZDHHC5_uc001nkz.1_5'UTR	NM_015457	NP_056272	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC domain containing 5	74						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)	1						AGGGATTTTCCCTCGAGGTAA	0.463000													25	42					0	0	0.006320	0	0
OR5B17	219965	broad.mit.edu	37	11	58125658	58125658	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:58125658C>T	uc010rke.1	-	1	885	c.885G>A	c.(883-885)GTG>GTA	p.V295V		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				ATGCATTCTTCACGTCTTTGT	0.373000													52	65					0	0	0.003610	0	0
OR5B21	219968	broad.mit.edu	37	11	58274899	58274899	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:58274899G>A	uc010rki.1	-	1	680	c.680C>T	c.(679-681)TCT>TTT	p.S227F		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CCCTTCAGCAGAATGCATCCT	0.453000													15	79					0	0	0.004007	0	0
OR4D6	219983	broad.mit.edu	37	11	59224654	59224654	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:59224654C>T	uc010rku.1	+	1	221	c.221C>T	c.(220-222)TCA>TTA	p.S74L		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCGTTTTTTCATCTATCACC	0.453000													45	87					0	0	0.009718	0	0
OR4D10	390197	broad.mit.edu	37	11	59244987	59244987	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:59244987C>T	uc001nnz.1	+	1	85	c.85C>T	c.(85-87)CTT>TTT	p.L29F		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						AGTCTTATTTCTTTTCCTACT	0.423000													72	98					0	0	0.003610	0	0
B3GAT3	26229	broad.mit.edu	37	11	62384138	62384138	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:62384138G>A	uc001ntw.2	-	4	778	c.749C>T	c.(748-750)CCT>CTT	p.P250L	B3GAT3_uc009ynz.2_Missense_Mutation_p.P243L|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Missense_Mutation_p.P250L	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	250	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						CATATCCACAGGGAAGGGCCT	0.642000													27	31					0	0	0.006320	0	0
NUMA1	4926	broad.mit.edu	37	11	71730594	71730594	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:71730594C>G	uc001orl.1	-	9	702	c.530G>C	c.(529-531)AGG>ACG	p.R177T	NUMA1_uc001ork.1_Missense_Mutation_p.R177T|NUMA1_uc001orm.1_Missense_Mutation_p.R177T|NUMA1_uc009ysx.1_Missense_Mutation_p.R177T|NUMA1_uc001oro.1_Missense_Mutation_p.R177T|NUMA1_uc009ysy.1_Missense_Mutation_p.R177T|NUMA1_uc001orp.2_Missense_Mutation_p.R177T|NUMA1_uc001orq.2_Missense_Mutation_p.R177T	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	177					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						GCGAATCTCCCTCTTGGCCTG	0.522000			T	RARA	APL								23	184					0	0	0.002299	0	0
NARS2	79731	broad.mit.edu	37	11	78282420	78282420	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:78282420C>T	uc001ozi.2	-	2	587	c.211G>A	c.(211-213)GAA>AAA	p.E71K	NARS2_uc010rsq.1_5'UTR	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	71					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	TGAAGGCTTTCCAAAGATGAC	0.403000													27	45					0	0	0.002445	0	0
DLG2	1740	broad.mit.edu	37	11	83874538	83874538	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:83874538A>C	uc001paj.2	-	4	578	c.275T>G	c.(274-276)ATT>AGT	p.I92S	DLG2_uc001pai.2_Missense_Mutation_p.I41S|DLG2_uc010rsy.1_Missense_Mutation_p.I59S|DLG2_uc010rsz.1_Missense_Mutation_p.I92S|DLG2_uc010rta.1_Missense_Mutation_p.I92S|DLG2_uc001pak.2_Missense_Mutation_p.I197S|DLG2_uc010rtb.1_Missense_Mutation_p.I59S|DLG2_uc001pal.1_Missense_Mutation_p.I92S|DLG2_uc001pam.1_Missense_Mutation_p.I131S	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	92						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TTCATATTCAATTTCTGTCCC	0.323000													3	72					0	0	0.009096	0	0
ANKRD49	54851	broad.mit.edu	37	11	94231258	94231258	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:94231258C>T	uc001pew.2	+	3	419	c.280C>T	c.(280-282)CTT>TTT	p.L94F	ANKRD49_uc001pex.2_3'UTR|ANKRD49_uc001pey.2_RNA	NM_017704	NP_060174	Q8WVL7	ANR49_HUMAN	fetal globin inducing factor	94	ANK 1.				positive regulation of transcription, DNA-dependent					central_nervous_system(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCGGAGACTCCTTTCTGAAAA	0.408000													39	43					0	0	0.007835	0	0
GRIA4	2893	broad.mit.edu	37	11	105774666	105774666	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:105774666C>T	uc001pix.2	+	8	1458	c.1012C>T	c.(1012-1014)CCA>TCA	p.P338S	GRIA4_uc001piu.1_Missense_Mutation_p.P338S|GRIA4_uc001piw.2_Missense_Mutation_p.P338S|GRIA4_uc009yxk.1_Missense_Mutation_p.P338S	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	338	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TCCTGCTGCTCCATGGGGCCA	0.418000													60	77					0	0	0.003610	0	0
MLL	4297	broad.mit.edu	37	11	118362000	118362000	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:118362000C>T	uc001pta.2	+	14	4809	c.4786C>T	c.(4786-4788)CAT>TAT	p.H1596Y	MLL_uc001ptb.2_Missense_Mutation_p.H1596Y|MLL_uc001pte.1_RNA	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1596	PHD-type 3.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TCGCTGGGTCCATTCCAAATG	0.388000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								22	63					0	0	0.004656	0	0
SORL1	6653	broad.mit.edu	37	11	121485591	121485591	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:121485591A>G	uc001pxx.2	+	41	5511	c.5431A>G	c.(5431-5433)ACA>GCA	p.T1811A	SORL1_uc010rzp.1_Missense_Mutation_p.T657A|SORL1_uc010rzq.1_Missense_Mutation_p.T426A	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1811	Extracellular (Potential).|Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGGCAATCTGACAGCTCATAC	0.468000													27	73					0	0	0.007291	0	0
LOC341056	341056	broad.mit.edu	37	11	122888594	122888594	+	RNA	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:122888594C>T	uc010rzt.1	+	1		c.321C>T				NR_027288				full-length cDNA clone CS0DC021YJ17 of Neuroblastoma Cot 25-normalized of Homo sapiens (human).												0						GTTCTTGATTCGTATTGGGTC	0.478000													40	85					0	0	0.004878	0	0
OR10G4	390264	broad.mit.edu	37	11	123886915	123886915	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:123886915C>T	uc010sac.1	+	1	634	c.634C>T	c.(634-636)CTG>TTG	p.L212L		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CTGCTTTGTCCTGATAGTGCT	0.562000													22	159					0	0	0.001882	0	0
VWA5A	4013	broad.mit.edu	37	11	123989325	123989325	+	Silent	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr11:123989325C>G	uc001pzu.2	+	6	764	c.555C>G	c.(553-555)ACC>ACG	p.T185T	VWA5A_uc001pzr.2_Silent_p.T185T|VWA5A_uc001pzs.2_Silent_p.T185T|VWA5A_uc010sae.1_Silent_p.T201T|VWA5A_uc001pzt.2_Silent_p.T185T	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	185										upper_aerodigestive_tract(1)|ovary(1)	2						TGGTCGCCACCATAGATTCCC	0.502000													15	104					0	0	0.002450	0	0
LRP6	4040	broad.mit.edu	37	12	12300476	12300476	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr12:12300476G>A	uc001rah.3	-	15	3363	c.3221C>T	c.(3220-3222)ACC>ATC	p.T1074I	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.T1074I	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1074	Extracellular (Potential).|LDL-receptor class B 18.|Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CTGAAGATTGGTAAAATACAT	0.378000													52	187					0	0	0.003610	0	0
ABCD2	225	broad.mit.edu	37	12	39967592	39967592	+	Silent	SNP	G	A	A	rs56388075		TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr12:39967592G>A	uc001rmb.2	-	9	2355	c.1929C>T	c.(1927-1929)GTC>GTT	p.V643V		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	643	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						TCTTTCCTTCGACATCAATGC	0.358000													41	23					0	0	0.002852	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45458414	45458415	+	RNA	DNP	CA	AT	AT			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr12:45458414_45458415CA>AT	uc001rol.2	-	1		c.780_781TG>AT				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						GCTCCTGGTCCAGTATGGCACA	0.520000													10	10					0	0	0.004672	0	0
KRT5	3852	broad.mit.edu	37	12	52913597	52913597	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr12:52913597G>A	uc001san.2	-	1	647	c.484C>T	c.(484-486)CAG>TAG	p.Q162*	KRT5_uc009zmh.2_Nonsense_Mutation_p.Q162*	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	162	Head.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		CTCACCCTCTGGATGCTGGGG	0.532000													62	39					0	0	0.003610	0	0
TRPV4	59341	broad.mit.edu	37	12	110246249	110246249	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr12:110246249G>A	uc001tpj.1	-	2	506	c.411C>T	c.(409-411)GCC>GCT	p.A137A	TRPV4_uc001tpg.1_Silent_p.A103A|TRPV4_uc001tph.1_Silent_p.A137A|TRPV4_uc001tpi.1_Silent_p.A137A|TRPV4_uc001tpk.1_Silent_p.A137A|TRPV4_uc001tpl.1_Silent_p.A137A	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	137	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GAGGGGCAGGGGCTTTGGGGC	0.657000													49	25					0	0	0.003610	0	0
ALDH2	217	broad.mit.edu	37	12	112219760	112219760	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr12:112219760G>A	uc001tst.2	+	2	594	c.153G>A	c.(151-153)AGG>AGA	p.R51R	ALDH2_uc010syi.1_Silent_p.R51R|ALDH2_uc009zvy.2_Silent_p.R51R	NM_000690	NP_000681	P05091	ALDH2_HUMAN	mitochondrial aldehyde dehydrogenase 2	51					carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase|electron carrier activity	p.R51K(1)		skin(2)|ovary(1)|central_nervous_system(1)	4					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)	CCGTCAGCAGGAAAACATTCC	0.483000			T	HMGA2	leiomyoma								30	20					0	0	0.002445	0	0
DNAH10	196385	broad.mit.edu	37	12	124411202	124411202	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr12:124411202G>A	uc001uft.3	+	68	11611	c.11586G>A	c.(11584-11586)ATG>ATA	p.M3862I	DNAH10_uc001ufu.3_5'UTR	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3862	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGCCCCCAATGATCAGCTTTG	0.517000													25	17					0	0	0.004656	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751421	19751421	+	Silent	SNP	G	A	A	rs142245280		TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr13:19751421G>A	uc009zzj.2	-	4	751	c.702C>T	c.(700-702)ATC>ATT	p.I234I		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	234					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TGGAGGACACGATCTGCCCAA	0.567000													37	84					0	0	0.004878	0	0
MYCBP2	23077	broad.mit.edu	37	13	77844529	77844529	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr13:77844529C>T	uc001vkf.2	-	7	1067	c.976G>A	c.(976-978)GAT>AAT	p.D326N	MYCBP2_uc010aev.2_5'UTR	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CATTGGTCATCTTCATCAACA	0.343000													7	44					0	0	0.001984	0	0
TM9SF2	9375	broad.mit.edu	37	13	100207827	100207827	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr13:100207827C>T	uc001voj.1	+	15	1811	c.1678C>T	c.(1678-1680)CTG>TTG	p.L560L	TM9SF2_uc010afz.1_Silent_p.L395L	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	560	Helical; (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					CTTCCTATTTCTGGTGTTTAT	0.333000													20	39					0	0	0.002780	0	0
F10	2159	broad.mit.edu	37	13	113803759	113803759	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr13:113803759C>T	uc001vsx.2	+	8	1452	c.1395C>T	c.(1393-1395)TCC>TCT	p.S465S	F10_uc001vsy.2_3'UTR|F10_uc001vsz.2_3'UTR	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	465	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCGACAGGTCCATGAAAACCA	0.572000													28	89					0	0	0.004656	0	0
LRRC16B	90668	broad.mit.edu	37	14	24530818	24530818	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr14:24530818C>T	uc001wlj.2	+	27	2574	c.2417C>T	c.(2416-2418)CCC>CTC	p.P806L	LRRC16B_uc001wlk.2_5'Flank	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	806										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		GTCACTGTGCCCCGGAACTTC	0.602000													11	38					0	0	0.002450	0	0
CTSG	1511	broad.mit.edu	37	14	25043691	25043691	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr14:25043691G>A	uc001wpq.2	-	4	391	c.354C>T	c.(352-354)GTC>GTT	p.V118V		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	118	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		GATTCCGTCTGACTCTTCTGC	0.642000													21	94					0	0	0.001882	0	0
SCFD1	23256	broad.mit.edu	37	14	31169460	31169460	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr14:31169460C>T	uc001wqm.1	+	16	1430	c.1406C>T	c.(1405-1407)TCT>TTT	p.S469F	SCFD1_uc001wqn.1_Missense_Mutation_p.S402F|SCFD1_uc010tpg.1_Missense_Mutation_p.S410F|SCFD1_uc010tph.1_Missense_Mutation_p.S284F|SCFD1_uc010amf.1_Missense_Mutation_p.S284F|SCFD1_uc010tpi.1_Missense_Mutation_p.S377F|SCFD1_uc010amd.1_Missense_Mutation_p.S301F|SCFD1_uc010ame.1_Missense_Mutation_p.S402F	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	469					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		CAAGCACCTTCTGAGGTATGT	0.358000													15	60					0	0	0.002450	0	0
PAPLN	89932	broad.mit.edu	37	14	73727416	73727416	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr14:73727416G>A	uc010ttx.1	+	16	2149	c.1986_splice	c.e16-1	p.R662_splice	PAPLN_uc001xnw.3_Splice_Site_p.R635_splice|PAPLN_uc010arl.2_Splice_Site|PAPLN_uc010ttw.1_Splice_Site|PAPLN_uc010tty.1_Splice_Site_p.R662_splice|PAPLN_uc010arm.2_5'Flank|PAPLN_uc010arn.2_5'Flank	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin							proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		TGTCTGCCTAGGTACGGGTGC	0.667000													23	40					0	0	0.002780	0	0
C14orf148	122945	broad.mit.edu	37	14	77861085	77861085	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr14:77861085G>A	uc001xtr.2	-	6	1116	c.969C>T	c.(967-969)CTC>CTT	p.L323L		NM_001113475	NP_001106946	Q6NXP6	CN148_HUMAN	hypothetical protein LOC122945 isoform 1	323					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		GACTACTTGAGAGATGCTGGC	0.443000													38	35					0	0	0.007835	0	0
NRXN3	9369	broad.mit.edu	37	14	79933605	79933605	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr14:79933605C>T	uc001xun.2	+	13	2676	c.2185C>T	c.(2185-2187)CTC>TTC	p.L729F	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.L97F|NRXN3_uc010asw.2_Missense_Mutation_p.L97F|NRXN3_uc001xur.3_Missense_Mutation_p.L97F	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1102	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TGGGCTTATCCTCTACACCTG	0.562000													12	54					0	0	0.000978	0	0
TC2N	123036	broad.mit.edu	37	14	92266635	92266635	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr14:92266635C>T	uc001xzu.3	-	5	742	c.551G>A	c.(550-552)CGA>CAA	p.R184Q	TC2N_uc001xzt.3_Missense_Mutation_p.R184Q|TC2N_uc010auc.2_Missense_Mutation_p.R184Q|TC2N_uc001xzv.3_Missense_Mutation_p.R184Q	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	184						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		CTGGATGAATCGCTGAGATGA	0.323000													3	7					0	0	0.004672	0	0
NDN	4692	broad.mit.edu	37	15	23931457	23931457	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:23931457G>A	uc001ywk.2	-	1	994	c.908C>T	c.(907-909)GCT>GTT	p.A303V		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	303					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CTCCCGCAGAGCTCTGGCCTC	0.567000									Prader-Willi_syndrome				33	48					0	0	0.009535	0	0
ARHGAP11B	89839	broad.mit.edu	37	15	30938316	30938316	+	Splice_Site	SNP	G	A	A	rs112615235	by1000genomes	TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:30938316G>A	uc010azv.1	+	11		c.1127_splice	c.e11-1		ARHGAP11B_uc001zeu.2_Splice_Site			Q3KRB8	RHGBB_HUMAN	Homo sapiens cDNA, FLJ17072.						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		all_lung(180;2.71e-09)|Breast(32;0.00116)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		TTCCTTGGCAGTGGATAAGTT	0.393000													3	20					0	0	0.004672	0	0
ARHGAP11B	89839	broad.mit.edu	37	15	30938440	30938440	+	RNA	SNP	A	G	G	rs115448147	by1000genomes	TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:30938440A>G	uc010azv.1	+	11		c.1250A>G			ARHGAP11B_uc001zeu.2_RNA			Q3KRB8	RHGBB_HUMAN	Homo sapiens cDNA, FLJ17072.						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		all_lung(180;2.71e-09)|Breast(32;0.00116)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		CTCCTTTGCTATTTGTGCATG	0.493000													3	29					0	0	0.004672	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32926163	32926163	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:32926163C>T	uc001zgy.1	+	10	1987	c.1265C>T	c.(1264-1266)TCT>TTT	p.S422F	ARHGAP11A_uc010ubw.1_Missense_Mutation_p.S233F|ARHGAP11A_uc001zgw.2_Missense_Mutation_p.S422F|ARHGAP11A_uc001zgx.2_Missense_Mutation_p.S394F|ARHGAP11A_uc010ubx.1_Missense_Mutation_p.S233F	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	422					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		GGCTGCTTTTCTCCTAAAATC	0.333000													12	9					0	0	0.001855	0	0
C15orf54	400360	broad.mit.edu	37	15	39544531	39544531	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:39544531C>T	uc001zkg.2	+	2	563	c.195C>T	c.(193-195)TTC>TTT	p.F65F		NM_207445	NP_997328	Q8N8G6	CO054_HUMAN	hypothetical protein LOC400360	65											0		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		CTCTCAGGTTCCTTTACATCG	0.438000													47	139					0	0	0.003610	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40259915	40259915	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:40259915G>A	uc001zkm.1	+	9	1438	c.1388G>A	c.(1387-1389)CGA>CAA	p.R463Q	EIF2AK4_uc001zkl.2_Missense_Mutation_p.R463Q|EIF2AK4_uc010bbj.1_Missense_Mutation_p.R192Q	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	463	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GAGCAAACCCGAGTTCGTTTT	0.488000													24	55					0	0	0.003330	0	0
FGF7	2252	broad.mit.edu	37	15	49775436	49775436	+	Silent	SNP	A	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:49775436A>G	uc001zxn.2	+	3	904	c.375A>G	c.(373-375)GGA>GGG	p.G125G	C15orf33_uc001zxl.2_Intron|C15orf33_uc001zxm.2_Intron	NM_002009	NP_002000	P21781	FGF7_HUMAN	fibroblast growth factor 7 precursor	125					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity				0		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	ACAAGGAAGGAAAACTCTATG	0.343000													5	18					0	0	0.001168	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651807	84651807	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:84651807G>A	uc002bjz.3	+	21	3651	c.3427G>A	c.(3427-3429)GAA>AAA	p.E1143K	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.E1143K|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.E1143K	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1143						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGGCATCCAGGAAGAGACACC	0.557000													10	27					0	0	0.000978	0	0
MRPS11	64963	broad.mit.edu	37	15	89015874	89015874	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:89015874C>T	uc002bml.2	+	3	464	c.199C>T	c.(199-201)CCA>TCA	p.P67S	MRPS11_uc002bmm.2_Intron|MRPS11_uc002bmn.2_Missense_Mutation_p.P66S|MRPS11_uc010bnj.2_RNA	NM_022839	NP_073750	P82912	RT11_HUMAN	mitochondrial ribosomal protein S11 isoform a	67					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0	Lung NSC(78;0.203)		BRCA - Breast invasive adenocarcinoma(143;0.188)			CCCTCCCATTCCAGGAGAGGA	0.373000													8	33					0	0	0.008291	0	0
BLM	641	broad.mit.edu	37	15	91298167	91298167	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:91298167C>T	uc002bpr.2	+	5	1183	c.1086C>T	c.(1084-1086)GAC>GAT	p.D362D	BLM_uc010uqh.1_Silent_p.D362D|BLM_uc010uqi.1_Translation_Start_Site|BLM_uc010bnx.2_Silent_p.D362D	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	362					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			CAGACTGTGACGGTACAAGCA	0.363000			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				26	131					0	0	0.003954	0	0
CHD2	1106	broad.mit.edu	37	15	93521462	93521462	+	Splice_Site	SNP	A	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:93521462A>G	uc002bsp.2	+	21	3153	c.2578_splice	c.e21-2	p.D860_splice	CHD2_uc002bso.1_Splice_Site_p.D860_splice|CHD2_uc010bog.1_Missense_Mutation_p.R133G|CHD2_uc010boh.1_Splice_Site_p.D54_splice	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2						regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CATTGTGTACAGGACTTCTGT	0.493000													31	43					0	0	0.002445	0	0
MCTP2	55784	broad.mit.edu	37	15	94841468	94841468	+	Translation_Start_Site	SNP	A	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:94841468A>T	uc002btj.2	+	1	39	c.-26A>T	c.(-28--24)GAAGT>GATGT		MCTP2_uc010urg.1_Translation_Start_Site|MCTP2_uc002bti.2_Translation_Start_Site|MCTP2_uc010boj.2_Translation_Start_Site|MCTP2_uc010bok.2_Translation_Start_Site|MCTP2_uc002btg.3_Translation_Start_Site|MCTP2_uc002bth.3_Translation_Start_Site	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			ACTTCTGAGAAGTGGCTTCTT	0.348000													15	52					0	0	0.002450	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100533320	100533320	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr15:100533320G>A	uc002bvv.1	-	20	2961	c.2882C>T	c.(2881-2883)CCG>CTG	p.P961L		NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	961	TSP type-1 4.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CTCGGCTCTCGGCCTCGTGGA	0.597000													39	55					0	0	0.004878	0	0
CLDN6	9074	broad.mit.edu	37	16	3065515	3065515	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:3065515C>T	uc002csu.3	-	2	568	c.508G>A	c.(508-510)GCC>ACC	p.A170T		NM_021195	NP_067018	P56747	CLD6_HUMAN	claudin 6	170	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						AGGCCTGAGGCCGCCCAGCCC	0.657000													12	8					0	0	0.001368	0	0
MEFV	4210	broad.mit.edu	37	16	3306468	3306468	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:3306468G>A	uc002cun.1	-	1	160	c.120C>T	c.(118-120)ATC>ATT	p.I40I		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	40	DAPIN.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	GGCTCCGGGGGATCCTGGAGT	0.592000													52	73					0	0	0.003610	0	0
CIITA	4261	broad.mit.edu	37	16	10997624	10997624	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:10997624G>A	uc002dai.3	+	9	942	c.809G>A	c.(808-810)AGT>AAT	p.S270N	CIITA_uc002daj.3_Missense_Mutation_p.S271N|CIITA_uc002dak.3_Missense_Mutation_p.S221N|CIITA_uc002dag.2_Missense_Mutation_p.S270N|CIITA_uc002dah.2_Missense_Mutation_p.S222N|CIITA_uc010bup.1_Missense_Mutation_p.S270N	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	270					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CCCCCTCCCAGTGGATTCACT	0.592000			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								40	43					0	0	0.007835	0	0
SNX29	92017	broad.mit.edu	37	16	12662371	12662371	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:12662371C>T	uc002dby.3	+	14	1228	c.1172C>T	c.(1171-1173)ACC>ATC	p.T391I		NM_001080530	NP_001073999	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	391	PX.				cell communication		phosphatidylinositol binding			ovary(1)	1						AGCGACATCACCCCGCCCGGA	0.637000													11	49					0	0	0.001855	0	0
PDXDC1	23042	broad.mit.edu	37	16	15125745	15125745	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:15125745C>G	uc002dda.3	+	17	1777	c.1553C>G	c.(1552-1554)TCT>TGT	p.S518C	PDXDC1_uc010uzl.1_Missense_Mutation_p.S503C|PDXDC1_uc010uzm.1_Missense_Mutation_p.S427C|PDXDC1_uc002ddb.3_Missense_Mutation_p.S491C|PDXDC1_uc010uzn.1_Missense_Mutation_p.S490C|PDXDC1_uc002ddc.2_Intron	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	518					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	CCTAACTGGTCTGGAATAGGG	0.473000													4	10					0	0	0.009096	0	0
PDILT	204474	broad.mit.edu	37	16	20376827	20376827	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:20376827C>T	uc002dhc.1	-	9	1375	c.1152G>A	c.(1150-1152)TGG>TGA	p.W384*		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	384					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						GTCCCTGGTCCCAGTATTTTG	0.448000													28	97					0	0	0.005443	0	0
DNAH3	55567	broad.mit.edu	37	16	21042506	21042506	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:21042506C>T	uc010vbe.1	-	37	5300	c.5300G>A	c.(5299-5301)TGG>TAG	p.W1767*		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1767	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ACCATCCATCCACTCGTGGCT	0.502000													40	51					0	0	0.002522	0	0
MVP	9961	broad.mit.edu	37	16	29859194	29859194	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:29859194C>T	uc002dui.2	+	15	2650	c.2566C>T	c.(2566-2568)CAG>TAG	p.Q856*	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc002duj.2_Nonsense_Mutation_p.Q856*|MVP_uc010vea.1_Nonsense_Mutation_p.Q450*	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	856					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GCCCGAGGGTCAGCCCCTGGG	0.647000													15	106					0	0	0.002450	0	0
SLC5A2	6524	broad.mit.edu	37	16	31498708	31498708	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:31498708C>T	uc002ecf.3	+	6	661	c.642C>T	c.(640-642)ATC>ATT	p.I214I	SLC5A2_uc010car.2_RNA|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	214	Helical; (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						GCGCCTGCATCCTCATGGGTT	0.706000													48	85					0	0	0.003610	0	0
ABCC12	94160	broad.mit.edu	37	16	48138243	48138243	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:48138243G>A	uc002efc.1	-	20	3056	c.2710C>T	c.(2710-2712)CCC>TCC	p.P904S	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_Intron|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	904	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				CTGCCAGTGGGAGTCGTGTCA	0.478000													45	58					0	0	0.003610	0	0
SLC12A3	6559	broad.mit.edu	37	16	56938370	56938370	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:56938370G>A	uc010ccm.2	+	25	2949	c.2920G>A	c.(2920-2922)GTC>ATC	p.V974I	SLC12A3_uc002ekd.3_Missense_Mutation_p.V983I|SLC12A3_uc010ccn.2_Missense_Mutation_p.V982I	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	974	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TGCTCTCATCGTCATGTAAGT	0.602000													5	96					0	0	0.001168	0	0
HTA	283902	broad.mit.edu	37	16	73127399	73127399	+	RNA	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:73127399G>A	uc010vmq.1	+	3		c.805G>A				NR_027756				Homo sapiens cDNA clone IMAGE:4544545, partial cds.												0						AGAAGAGATGGAGTCATAGCT	0.572000													4	9					0	0	0.009096	0	0
HSD17B2	3294	broad.mit.edu	37	16	82101883	82101883	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:82101883G>A	uc002fgv.2	+	2	546	c.374G>A	c.(373-375)CGA>CAA	p.R125Q		NM_002153	NP_002144	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	125					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			ovary(1)|central_nervous_system(1)	2					NADH(DB00157)	GAGGAATTGCGAAGAACCTGC	0.527000													21	22					0	0	0.008871	0	0
KIAA0513	9764	broad.mit.edu	37	16	85100908	85100908	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr16:85100908C>T	uc002fiu.2	+	2	451	c.231C>T	c.(229-231)TCC>TCT	p.S77S	KIAA0513_uc002fis.3_Silent_p.S77S|KIAA0513_uc010voj.1_Silent_p.S77S|KIAA0513_uc002fit.2_Silent_p.S77S	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	77						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		CCAACGAGTCCTTCTCCTCCA	0.592000													12	53					0	0	0.001368	0	0
OR3A3	8392	broad.mit.edu	37	17	3324755	3324755	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:3324755C>T	uc010vrd.1	+	1	894	c.894C>T	c.(892-894)ATC>ATT	p.I298I		NM_012373	NP_036505	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A,	298	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACCCACTTATCTACAGCCTCA	0.498000													33	70					0	0	0.003755	0	0
ATP1B2	482	broad.mit.edu	37	17	7554890	7554890	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:7554890G>A	uc002gif.1	+	1	637	c.54G>A	c.(52-54)AAG>AAA	p.K18K		NM_001678	NP_001669	P14415	AT1B2_HUMAN	Na+/K+ -ATPase beta 2 subunit	18	Cytoplasmic (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		AGGAGTGGAAGGAGTTCGTGT	0.692000													9	8					0	0	0.006214	0	0
PER1	5187	broad.mit.edu	37	17	8049412	8049412	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:8049412C>T	uc002gkd.2	-	17	2320	c.2082G>A	c.(2080-2082)CGG>CGA	p.R694R	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Silent_p.R678R	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	694	CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						CTGGCTCCTTCCGTGGGGTGG	0.647000			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					22	64					0	0	0.002299	0	0
GLP2R	9340	broad.mit.edu	37	17	9783717	9783717	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:9783717C>T	uc002gmd.1	+	11	1168	c.1168C>T	c.(1168-1170)CTC>TTC	p.L390F		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	390	Helical; Name=6; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	AACACTGGTCCTCATTCCTTT	0.413000													69	122					0	0	0.003610	0	0
RICH2	9912	broad.mit.edu	37	17	12883398	12883398	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:12883398C>G	uc002gnr.3	+	19	2114	c.1787C>G	c.(1786-1788)TCT>TGT	p.S596C	RICH2_uc010vvk.1_Missense_Mutation_p.S596C|RICH2_uc010vvl.1_Missense_Mutation_p.S590C|RICH2_uc002gns.3_Missense_Mutation_p.S390C|RICH2_uc010vvm.1_Missense_Mutation_p.S590C|RICH2_uc010vvn.1_Intron	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	596					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						AAGGAACTTTCTCCAGGCTCT	0.582000													10	40					0	0	0.008291	0	0
LLGL1	3996	broad.mit.edu	37	17	18137691	18137691	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:18137691G>A	uc002gsp.2	+	7	880	c.819G>A	c.(817-819)ACG>ACA	p.T273T		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	273					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					GCTTCCCAACGCTGCAGCCCA	0.617000													4	18					0	0	0.000602	0	0
TOP3A	7156	broad.mit.edu	37	17	18178138	18178138	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:18178138G>A	uc002gsx.1	-	19	3213	c.2984C>T	c.(2983-2985)CCC>CTC	p.P995L	TOP3A_uc010cpz.1_Missense_Mutation_p.P447L|TOP3A_uc010vxr.1_Missense_Mutation_p.P525L|TOP3A_uc002gsw.1_Missense_Mutation_p.P447L|TOP3A_uc010vxs.1_Missense_Mutation_p.P893L	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	995					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						AGGACAAAAGGGACGGGTGTG	0.542000													31	78					0	0	0.003271	0	0
MIR144	406936	broad.mit.edu	37	17	27188633	27188633	+	RNA	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:27188633C>T	hsa-mir-144|MI0000460	-			c.4C>T			MIR451_hsa-mir-451|MI0001729_5'Flank|uc010waz.1_RNA																	0						CAGCCAGGGCCCCACTGGGGG	0.562000													5	18					0	0	0.000602	0	0
ACCN1	40	broad.mit.edu	37	17	31355372	31355372	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:31355372G>A	uc002hhu.2	-	4	1147	c.873C>T	c.(871-873)TCC>TCT	p.S291S	ACCN1_uc002hht.2_Silent_p.S342S	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	291	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	CCATCTCTGAGGATCGGCACT	0.542000													24	40					0	0	0.003954	0	0
KRT37	8688	broad.mit.edu	37	17	39578686	39578686	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:39578686C>T	uc002hwp.1	-	4	780	c.733G>A	c.(733-735)GAA>AAA	p.E245K	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	245	Rod.|Coil 1B.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				ATCTTTACTTCCTGCAGAAAT	0.567000													51	91					0	0	0.003610	0	0
TUBG2	27175	broad.mit.edu	37	17	40817713	40817713	+	Silent	SNP	G	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:40817713G>C	uc010wgr.1	+	8	967	c.711G>C	c.(709-711)TCG>TCC	p.S237S	TUBG2_uc002iaq.2_Silent_p.S79S|TUBG2_uc002iar.2_Silent_p.S84S|TUBG2_uc002ias.2_Silent_p.S79S|TUBG2_uc002iap.2_Silent_p.S84S	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	237					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		CCATCATGTCGGCCAGCACCA	0.632000													42	60					0	0	0.003214	0	0
CNTD1	124817	broad.mit.edu	37	17	40956324	40956324	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:40956324G>A	uc002ibm.3	+	3	559	c.327G>A	c.(325-327)TGG>TGA	p.W109*	CNTD1_uc010wha.1_Nonsense_Mutation_p.W26*	NM_173478	NP_775749	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	109	Cyclin N-terminal.									central_nervous_system(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CTCAGAATTGGAGGGCTCTGA	0.473000													40	75					0	0	0.003214	0	0
ITGA2B	3674	broad.mit.edu	37	17	42457127	42457127	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:42457127G>A	uc002igt.1	-	18	1840	c.1808C>T	c.(1807-1809)TCC>TTC	p.S603F	ITGA2B_uc002igu.1_Missense_Mutation_p.S84F	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	603	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGGCGGTAGGGACACATTGAG	0.612000													59	84					0	0	0.003610	0	0
PRR15L	79170	broad.mit.edu	37	17	46030598	46030598	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:46030598C>T	uc002imp.2	-	2	120	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_024320	NP_077296	Q9BU68	PR15L_HUMAN	ATPase family, AAA domain containing 4	1										ovary(1)	1						TTTCAGTCGTCATGGCGCTCC	0.547000													49	82					0	0	0.003610	0	0
TTLL6	284076	broad.mit.edu	37	17	46867331	46867331	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:46867331C>T	uc010wlo.1	-	11	1397	c.1362G>A	c.(1360-1362)CGG>CGA	p.R454R	TTLL6_uc002iob.2_Silent_p.R147R|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Silent_p.R207R|TTLL6_uc002iod.2_Silent_p.R301R	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	406						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						GGAACTGCCCCCGTTGTCTCT	0.522000													22	37					0	0	0.001882	0	0
MYST2	11143	broad.mit.edu	37	17	47904851	47904851	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:47904851C>T	uc002ipm.2	+	15	1949	c.1823C>T	c.(1822-1824)CCC>CTC	p.P608L	MYST2_uc010wma.1_Missense_Mutation_p.P469L|MYST2_uc010wmb.1_Missense_Mutation_p.P498L|MYST2_uc010wmc.1_Missense_Mutation_p.P439L|MYST2_uc010wmd.1_Missense_Mutation_p.P452L|MYST2_uc010wme.1_Missense_Mutation_p.P422L|MYST2_uc010wmf.1_Missense_Mutation_p.P273L|MYST2_uc010wmg.1_Missense_Mutation_p.P163L	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	608					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TGGACCCCTCCCAAGGGCACT	0.507000													16	39					0	0	0.004990	0	0
RAD51C	5889	broad.mit.edu	37	17	56787223	56787223	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:56787223C>T	uc002iwu.2	+	5	751	c.709C>T	c.(709-711)CGA>TGA	p.R237*	RAD51C_uc010woa.1_Nonsense_Mutation_p.R237*|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	237					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TATTTAGGTTCGACTAGTGAT	0.368000								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				34	90					0	0	0.004289	0	0
BRIP1	83990	broad.mit.edu	37	17	59934423	59934423	+	Silent	SNP	A	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:59934423A>G	uc002izk.1	-	4	516	c.375T>C	c.(373-375)TGT>TGC	p.C125C		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	125	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						AATTACCTTGACAAGTTGATG	0.333000			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				3	126					0	0	0.009096	0	0
TANC2	26115	broad.mit.edu	37	17	61498424	61498424	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:61498424A>T	uc002jal.3	+	25	5104	c.5081A>T	c.(5080-5082)AAA>ATA	p.K1694I	TANC2_uc010wpe.1_3'UTR|TANC2_uc002jao.3_Missense_Mutation_p.K805I	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1694							binding			ovary(2)	2						GGATTGACCAAAGAGGATCTT	0.572000													29	160					0	0	0.006320	0	0
OTOP2	92736	broad.mit.edu	37	17	72920943	72920943	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:72920943G>A	uc010wrp.1	+	3	305	c.216G>A	c.(214-216)CTG>CTA	p.L72L	USH1G_uc002jme.1_5'Flank|USH1G_uc010wro.1_5'Flank|OTOP2_uc002jmf.1_Silent_p.L72L	NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	72	Helical; (Potential).					integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					TGATGCTGCTGGCAACGCTCT	0.662000													7	16					0	0	0.001984	0	0
KIAA0195	9772	broad.mit.edu	37	17	73489115	73489115	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:73489115C>T	uc002jnz.3	+	16	2293	c.2018C>T	c.(2017-2019)TCC>TTC	p.S673F	KIAA0195_uc010wsa.1_Missense_Mutation_p.S683F|KIAA0195_uc010wsb.1_Missense_Mutation_p.S313F|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	673					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGGCGGCTCTCCTGTGTCACC	0.612000													37	58					0	0	0.004878	0	0
UBE2O	63893	broad.mit.edu	37	17	74387350	74387350	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:74387350G>A	uc002jrm.3	-	18	3618	c.3553C>T	c.(3553-3555)CCT>TCT	p.P1185S	UBE2O_uc002jrl.3_Missense_Mutation_p.P789S	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	1185							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						CCATCCTCAGGTTCTTGTTGG	0.682000													35	77					0	0	0.003755	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77040134	77040134	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr17:77040134C>T	uc002jwp.2	+	2	424	c.84C>T	c.(82-84)CCC>CCT	p.P28P	C1QTNF1_uc002jwq.2_Intron|C1QTNF1_uc002jwr.3_Silent_p.P38P|C1QTNF1_uc002jws.2_Silent_p.P28P|C1QTNF1_uc002jwt.2_Silent_p.P126P	NM_030968	NP_112230	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	28						collagen				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			GTCGTGTGCCCCATGTCCAGG	0.662000													28	41					0	0	0.006320	0	0
PIK3C3	5289	broad.mit.edu	37	18	39623705	39623705	+	Silent	SNP	T	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr18:39623705T>C	uc002lap.2	+	20	2170	c.2112T>C	c.(2110-2112)TTT>TTC	p.F704F	PIK3C3_uc010xcl.1_Silent_p.F641F|PIK3C3_uc002laq.2_Silent_p.F189F|PIK3C3_uc002lar.1_Silent_p.F88F	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	704	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						AGAACTTTTTTAGAAAATATG	0.338000										TSP Lung(28;0.18)			10	43					0	0	0.001368	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560359	44560359	+	Missense_Mutation	SNP	G	A	A	rs150911848		TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr18:44560359G>A	uc002lcr.1	-	1	1630	c.1277C>T	c.(1276-1278)TCG>TTG	p.S426L	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	426					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TTTCTTAGCCGAATCCCAGGA	0.547000													20	94					0	0	0.007413	0	0
SERPINB7	8710	broad.mit.edu	37	18	61459658	61459658	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr18:61459658G>A	uc002ljl.2	+	3	296	c.200G>A	c.(199-201)GGA>GAA	p.G67E	SERPINB7_uc002ljm.2_Missense_Mutation_p.G67E|SERPINB7_uc010xet.1_Intron|SERPINB7_uc010dqg.2_Missense_Mutation_p.G67E	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	67					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				TCAGGATATGGAAACTCTTCT	0.294000													10	50					0	0	0.006214	0	0
MCOLN1	57192	broad.mit.edu	37	19	7593136	7593136	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:7593136C>T	uc002mgo.2	+	7	995	c.870C>T	c.(868-870)TTC>TTT	p.F290F	MCOLN1_uc002mgp.2_Silent_p.F255F	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	290					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						CCAGTGTCTTCCAGCACGGTG	0.647000													17	22					0	0	0.004990	0	0
MUC16	94025	broad.mit.edu	37	19	9013898	9013898	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:9013898G>A	uc002mkp.2	-	33	38696	c.38492C>T	c.(38491-38493)TCC>TTC	p.S12831F	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12833	Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCCACTGTGGAGGTCCCAGG	0.483000													6	16					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9063802	9063802	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:9063802C>T	uc002mkp.2	-	3	23848	c.23644G>A	c.(23644-23646)GAC>AAC	p.D7882N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7884	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGAGATGTCTGGTGATATT	0.507000													16	75					0	0	0.003163	0	0
SLC44A2	57153	broad.mit.edu	37	19	10747042	10747042	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:10747042G>A	uc002mpf.2	+	15	1416	c.1277G>A	c.(1276-1278)CGT>CAT	p.R426H	SLC44A2_uc002mpe.3_Missense_Mutation_p.R424H|SLC44A2_uc002mpg.1_Missense_Mutation_p.R146H|SLC44A2_uc002mph.2_5'UTR	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	426	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	CCCAATGCCCGTTGCCAGTTC	0.592000													33	52					0	0	0.003271	0	0
PLVAP	83483	broad.mit.edu	37	19	17476249	17476249	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:17476249C>T	uc002ngk.1	-	3	1075	c.1025G>A	c.(1024-1026)CGG>CAG	p.R342Q		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	342	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CTGGGTCTGCCGGGAGCATTC	0.647000													12	48					0	0	0.001855	0	0
SFRS14	10147	broad.mit.edu	37	19	19135734	19135734	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:19135734G>A	uc002nkx.2	-	3	1569	c.1423C>T	c.(1423-1425)CTC>TTC	p.L475F	SFRS14_uc002nkz.1_Missense_Mutation_p.L489F|SFRS14_uc002nla.1_Missense_Mutation_p.L475F|SFRS14_uc002nlb.2_Missense_Mutation_p.L475F|SFRS14_uc010xqk.1_Missense_Mutation_p.L244F	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	475					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			TTCCGGCAGAGAGAGTTGGTG	0.507000													101	125					0	0	0.003610	0	0
ZNF43	7594	broad.mit.edu	37	19	22000695	22000696	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:22000695_22000696GG>AA	uc002nqj.2	-	3	353_354	c.223_224CC>TT	c.(223-225)CCC>TTC	p.P75F	ZNF43_uc010ecv.2_Missense_Mutation_p.P69F|ZNF43_uc002nql.2_Missense_Mutation_p.P69F|ZNF43_uc002nqm.2_Missense_Mutation_p.P69F|ZNF43_uc002nqk.2_Missense_Mutation_p.P5F	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	75	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		CCTACCTGGGGGTTTGGCTACC	0.465000													32	102					0	0	0.004672	0	0
ZNF536	9745	broad.mit.edu	37	19	31039854	31039854	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:31039854G>A	uc002nsu.1	+	4	3466	c.3328G>A	c.(3328-3330)GAC>AAC	p.D1110N	ZNF536_uc010edd.1_Missense_Mutation_p.D1110N	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1110					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CTTCCCATCAGACTTCTACAA	0.557000													31	42					0	0	0.002096	0	0
GRAMD1A	57655	broad.mit.edu	37	19	35510325	35510325	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:35510325G>A	uc010xse.1	+	13	1500	c.1363G>A	c.(1363-1365)GGG>AGG	p.G455R	GRAMD1A_uc002nxk.2_Missense_Mutation_p.G448R|GRAMD1A_uc002nxl.2_Missense_Mutation_p.G221R|GRAMD1A_uc010xsf.1_Missense_Mutation_p.G460R|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Missense_Mutation_p.G70R	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	455						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CCAGGCCGGCGGGTGTGTGGT	0.687000													18	70					0	0	0.007413	0	0
LSR	51599	broad.mit.edu	37	19	35752867	35752867	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:35752867A>G	uc002nyl.2	+	4	981	c.758A>G	c.(757-759)CAG>CGG	p.Q253R	LSR_uc002nym.2_Intron|LSR_uc002nyn.2_Intron|LSR_uc002nyo.2_Intron|LSR_uc010xsr.1_Intron|LSR_uc002nyp.2_Missense_Mutation_p.Q216R	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	253	Extracellular (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCTGGTTTTCAGGCGGGGCCC	0.577000													4	136					0	0	0.001168	0	0
ZNF540	163255	broad.mit.edu	37	19	38103185	38103185	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:38103185C>T	uc002ogq.2	+	5	1336	c.1004C>T	c.(1003-1005)GCT>GTT	p.A335V	ZNF540_uc002ogu.2_Missense_Mutation_p.A335V|ZNF540_uc010efq.2_Missense_Mutation_p.A303V	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	335	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTGGGAAAGCTTTTAGTGTA	0.348000													22	28					0	0	0.003330	0	0
CEACAM1	634	broad.mit.edu	37	19	43031363	43031363	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:43031363C>T	uc002otv.2	-	2	367	c.254G>A	c.(253-255)GGA>GAA	p.G85E	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|CEACAM1_uc002otw.2_Missense_Mutation_p.G85E|CEACAM1_uc010eij.2_Missense_Mutation_p.G85E|CEACAM1_uc002otx.2_Missense_Mutation_p.G85E|CEACAM1_uc002oty.2_Missense_Mutation_p.G85E|CEACAM1_uc002otz.2_Missense_Mutation_p.G85E|CEACAM1_uc010eik.2_Missense_Mutation_p.G85E|CEACAM1_uc002oua.2_Missense_Mutation_p.G85E|CEACAM1_uc002oub.2_Missense_Mutation_p.G85E|CEACAM1_uc002ouc.2_Missense_Mutation_p.G85E	NM_001712	NP_001703	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion	85	Ig-like V-type.|Extracellular (Potential).				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				ovary(1)|central_nervous_system(1)	2		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	TTGTTGAGTTCCTATTGCATA	0.507000													21	213					0	0	0.005443	0	0
ERCC2	2068	broad.mit.edu	37	19	45855574	45855574	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:45855574G>A	uc002pbj.2	-	22	2130	c.2083C>T	c.(2083-2085)CGC>TGC	p.R695C	ERCC2_uc002pbh.2_Missense_Mutation_p.R258C|ERCC2_uc002pbi.2_Missense_Mutation_p.R388C|ERCC2_uc010ejz.2_Missense_Mutation_p.R617C|ERCC2_uc002pbk.2_Missense_Mutation_p.R671C	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	695	Nuclear localization signal (Potential).				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TGGATCCAGCGGGGCAGCTTC	0.652000			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				20	40					0	0	0.002299	0	0
EMP3	2014	broad.mit.edu	37	19	48833692	48833692	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:48833692G>A	uc002piv.2	+	5	711	c.457G>A	c.(457-459)GGC>AGC	p.G153S		NM_001425	NP_001416	P54852	EMP3_HUMAN	epithelial membrane protein 3	153	Helical; (Potential).				cell growth|negative regulation of cell proliferation	integral to membrane					0		all_epithelial(76;6.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.00989)|Prostate(7;0.0143)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		CCTGGTCAGCGGCATCATCTA	0.468000													24	27					0	0	0.006320	0	0
HRC	3270	broad.mit.edu	37	19	49657367	49657367	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:49657367C>T	uc002pmv.2	-	1	1315	c.1128G>A	c.(1126-1128)GAG>GAA	p.E376E		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	376					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CTTCCTCTTCCTCATCTACAA	0.532000													11	85					0	0	0.000978	0	0
ZNF473	25888	broad.mit.edu	37	19	50549410	50549410	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:50549410C>T	uc002prn.2	+	5	1947	c.1710C>T	c.(1708-1710)ACC>ACT	p.T570T	ZNF473_uc002prm.2_Silent_p.T570T|ZNF473_uc010ybo.1_Silent_p.T558T	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	570	C2H2-type 11.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		GTGAGAAAACCTTTAGCTGCA	0.443000													4	23					0	0	0.009096	0	0
ZNF578	147660	broad.mit.edu	37	19	53014785	53014785	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:53014785C>T	uc002pzp.3	+	6	1395	c.1151C>T	c.(1150-1152)TCA>TTA	p.S384L		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	159	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		GGTCAAAATTCAACCCTTGTA	0.378000													22	45					0	0	0.001882	0	0
ZNF83	55769	broad.mit.edu	37	19	53116513	53116513	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:53116513C>T	uc002pzu.3	-	2	2549	c.1305G>A	c.(1303-1305)GGG>GGA	p.G435G	ZNF83_uc002pzv.3_Silent_p.G435G|ZNF83_uc010eps.2_Silent_p.G407G|ZNF83_uc010ept.2_Silent_p.G435G|ZNF83_uc010epu.2_Silent_p.G435G|ZNF83_uc010epv.2_Silent_p.G435G|ZNF83_uc010epw.2_Silent_p.G435G|ZNF83_uc010epx.2_Silent_p.G407G|ZNF83_uc010epy.2_Silent_p.G435G|ZNF83_uc010epz.2_Silent_p.G407G	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	435	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		CGAAGACCTTCCCACATTCAT	0.368000													17	60					0	0	0.004007	0	0
ZNF160	90338	broad.mit.edu	37	19	53572054	53572054	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:53572054G>A	uc010eqk.2	-	7	2149	c.1733C>T	c.(1732-1734)TCA>TTA	p.S578L	ZNF160_uc002qaq.3_Missense_Mutation_p.S578L|ZNF160_uc002qar.3_Missense_Mutation_p.S578L	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	578	C2H2-type 12.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		TGCAAGTTGTGATGTTTGAGC	0.403000													33	53					0	0	0.004878	0	0
LILRA3	11026	broad.mit.edu	37	19	54803141	54803141	+	Missense_Mutation	SNP	C	G	G	rs147561158	byFrequency	TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:54803141C>G	uc002qfd.2	-	4	601	c.536G>C	c.(535-537)CGG>CCG	p.R179P	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	179	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GAAGATGGCCCGGGATGACCC	0.567000													22	13					0	0	0.001882	0	0
LILRA2	11027	broad.mit.edu	37	19	55086786	55086786	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:55086786T>C	uc002qgg.3	+	5	808	c.719T>C	c.(718-720)CTG>CCG	p.L240P	LILRA2_uc010ern.2_Missense_Mutation_p.L240P|LILRA2_uc002qgf.2_Missense_Mutation_p.L240P|LILRA2_uc010yfe.1_Missense_Mutation_p.L240P|LILRA2_uc010yff.1_Missense_Mutation_p.L228P|LILRA2_uc010ero.2_Missense_Mutation_p.L228P|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	240	Ig-like C2-type 3.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		GGGGAGAGCCTGACCCTCCAG	0.577000													3	90					0	0	0.004672	0	0
ZNF264	9422	broad.mit.edu	37	19	57724217	57724217	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:57724217C>T	uc002qob.2	+	4	2165	c.1752C>T	c.(1750-1752)ACC>ACT	p.T584T		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		CCTCAGTTACCCTTCGAGAAC	0.438000													43	48					0	0	0.009718	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58598304	58598304	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr19:58598304G>C	uc002qri.2	-	5	1023	c.714C>G	c.(712-714)AAC>AAG	p.N238K	ZSCAN18_uc002qrj.3_Missense_Mutation_p.N238K|ZSCAN18_uc010yhs.1_Missense_Mutation_p.N103K|ZSCAN18_uc002qrh.2_Missense_Mutation_p.N238K|ZSCAN18_uc010yht.1_Missense_Mutation_p.N294K|ZSCAN18_uc002qrk.1_3'UTR|ZSCAN18_uc002qrl.2_3'UTR	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	238					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGCTCTTCAGGTTCTCCTCGG	0.637000													6	58					0	0	0.001168	0	0
TPO	7173	broad.mit.edu	37	2	1457561	1457561	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:1457561C>T	uc002qww.2	+	6	669	c.578C>T	c.(577-579)CCC>CTC	p.P193L	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.P193L|TPO_uc002qwr.2_Missense_Mutation_p.P193L|TPO_uc002qwx.2_Missense_Mutation_p.P193L|TPO_uc010yio.1_Missense_Mutation_p.P193L|TPO_uc010yip.1_Missense_Mutation_p.P193L	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	193	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGCTGGAACCCCGGCTTCTTG	0.607000													5	54					0	0	0.000602	0	0
TPO	7173	broad.mit.edu	37	2	1507809	1507809	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:1507809G>A	uc002qww.2	+	14	2567	c.2476G>A	c.(2476-2478)GCG>ACG	p.A826T	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.A769T|TPO_uc002qwr.2_Missense_Mutation_p.A826T|TPO_uc002qwx.2_Missense_Mutation_p.A769T|TPO_uc010yio.1_Missense_Mutation_p.A653T|TPO_uc010yip.1_Intron|TPO_uc002qwy.1_Intron|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	826	Extracellular (Potential).|EGF-like; calcium-binding (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GTGTCTCTGCGCGGACCCCTA	0.577000													19	37					0	0	0.008871	0	0
MAP4K3	8491	broad.mit.edu	37	2	39542498	39542498	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:39542498G>A	uc002rro.2	-	13	1041	c.950C>T	c.(949-951)TCA>TTA	p.S317L	MAP4K3_uc002rrp.2_Missense_Mutation_p.S317L|MAP4K3_uc010yns.1_5'UTR	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	317					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TCTACTTGTTGAGTGAATTCT	0.313000													12	23					0	0	0.001855	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48873959	48873959	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:48873959G>A	uc010yol.1	+	5	2774	c.2727G>A	c.(2725-2727)CAG>CAA	p.Q909Q	STON1-GTF2A1L_uc002rwp.1_Silent_p.Q956Q|GTF2A1L_uc002rws.1_Silent_p.Q252Q|GTF2A1L_uc010yom.1_Silent_p.Q218Q|GTF2A1L_uc002rwt.2_Silent_p.Q252Q	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	909					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTTCTCCACAGGTCTCTCAAA	0.448000													9	42					0	0	0.008291	0	0
SPRED2	200734	broad.mit.edu	37	2	65540880	65540881	+	Missense_Mutation	DNP	GG	AT	AT			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:65540880_65540881GG>AT	uc002sdr.3	-	6	1546_1547	c.1011_1012CC>AT	c.(1009-1014)ATCCGC>ATATGC	p.R338C	SPRED2_uc010fcw.2_Missense_Mutation_p.R335C	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	338	SPR.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CTCACCCGGCGGATGCAAGTTC	0.624000													23	95					0	0	0.004672	0	0
NCK2	8440	broad.mit.edu	37	2	106498299	106498299	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:106498299C>T	uc002tdg.2	+	4	1184	c.742C>T	c.(742-744)CCC>TCC	p.P248S	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Missense_Mutation_p.P248S	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	248	SH3 3.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GGGCCTCGTCCCCAAAAACTA	0.637000													21	49					0	0	0.002299	0	0
NPHP1	4867	broad.mit.edu	37	2	110904336	110904336	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:110904336G>A	uc002tfn.3	-	14	1605	c.1511C>T	c.(1510-1512)CCA>CTA	p.P504L	NPHP1_uc002tfm.3_Missense_Mutation_p.P449L|NPHP1_uc002tfl.3_Missense_Mutation_p.P505L|NPHP1_uc002tfo.3_Missense_Mutation_p.P386L|NPHP1_uc010ywx.1_Missense_Mutation_p.P448L|NPHP1_uc010fjv.1_Missense_Mutation_p.P448L	NM_207181	NP_997064	O15259	NPHP1_HUMAN	nephrocystin 1 isoform 2	504					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			ovary(2)	2						TTACTTTGCTGGAATAGGAAC	0.368000													10	54					0	0	0.008291	0	0
GLI2	2736	broad.mit.edu	37	2	121746991	121746991	+	Silent	SNP	T	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:121746991T>A	uc010flp.2	+	13	3531	c.3501T>A	c.(3499-3501)CCT>CCA	p.P1167P	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Silent_p.P839P|GLI2_uc002tmu.3_Silent_p.P822P	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1167					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CACCCTTTCCTCAGGGCAACC	0.627000													14	13					0	0	0.002450	0	0
MYO7B	4648	broad.mit.edu	37	2	128387248	128387249	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:128387248_128387249GG>AA	uc002top.2	+	34	4628_4629	c.4575_4576GG>AA	c.(4573-4578)AAGGGG>AAAAGG	p.G1526R	MYO7B_uc002tor.1_Missense_Mutation_p.G379R	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1526	SH3 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CCTTCAAGAAGGGGGACCTGTT	0.604000													6	17					0	0	0.004672	0	0
THSD7B	80731	broad.mit.edu	37	2	137872745	137872745	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:137872745C>T	uc002tva.1	+	4	1158	c.1158C>T	c.(1156-1158)CTC>CTT	p.L386L	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.L276L	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTCTCCTCCTCGAGCAGCAGG	0.512000													12	32					0	0	0.001855	0	0
LRP1B	53353	broad.mit.edu	37	2	141459374	141459374	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:141459374C>T	uc002tvj.1	-	40	7315	c.6343G>A	c.(6343-6345)GAT>AAT	p.D2115N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2115	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTGTGGCATCATTCTTGTGG	0.428000										TSP Lung(27;0.18)			27	38					0	0	0.009535	0	0
ERMN	57471	broad.mit.edu	37	2	158178151	158178151	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:158178151G>A	uc002tzh.2	-	3	749	c.487C>T	c.(487-489)CGA>TGA	p.R163*	ERMN_uc010zcj.1_Nonsense_Mutation_p.R57*|ERMN_uc010zck.1_Nonsense_Mutation_p.R143*|ERMN_uc002tzi.2_Nonsense_Mutation_p.R176*	NM_020711	NP_065762	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein isoform b	163						cytoplasm|cytoskeleton				ovary(1)|skin(1)	2						CTAGGTTTTCGAAATCCCAGC	0.378000													40	65					0	0	0.007835	0	0
TTN	7273	broad.mit.edu	37	2	179407493	179407493	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:179407493T>A	uc010zfg.1	-	297	89608	c.89384A>T	c.(89383-89385)AAA>ATA	p.K29795I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K23490I|TTN_uc010zfi.1_Missense_Mutation_p.K23423I|TTN_uc010zfj.1_Missense_Mutation_p.K23298I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30722							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATGGTTAATTTAGCTACTTT	0.413000													45	129					0	0	0.009718	0	0
TTN	7273	broad.mit.edu	37	2	179479461	179479461	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:179479461G>A	uc010zfg.1	-	210	41300	c.41076C>T	c.(41074-41076)CTC>CTT	p.L13692L	uc002ump.1_RNA|TTN_uc010zfh.1_Silent_p.L7387L|TTN_uc010zfi.1_Silent_p.L7320L|TTN_uc010zfj.1_Silent_p.L7195L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14619							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCACATCGAGGAAGATTT	0.408000													11	20					0	0	0.001368	0	0
TTN	7273	broad.mit.edu	37	2	179544088	179544088	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:179544088C>T	uc010zfg.1	-	139	30212	c.29988G>A	c.(29986-29988)AAG>AAA	p.K9996K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.K6657K|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10923							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGGCTTCTCCTTTTTAGGAA	0.398000													19	51					0	0	0.008871	0	0
TTN	7273	broad.mit.edu	37	2	179598554	179598554	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:179598554G>T	uc010zfg.1	-	50	12054	c.11830C>A	c.(11830-11832)CAA>AAA	p.Q3944K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.Q605K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4871							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGCAGCTTGCAGGGTAACG	0.413000													21	74					2.89027e-11	3.17929e-11	0.002299	1	0
GLS	2744	broad.mit.edu	37	2	191795258	191795258	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:191795258G>T	uc002usf.2	+	13	1785	c.1521G>T	c.(1519-1521)AAG>AAT	p.K507N	GLS_uc002use.2_Missense_Mutation_p.K507N|GLS_uc002usg.1_Missense_Mutation_p.K168N|GLS_uc002ush.2_Missense_Mutation_p.K168N|GLS_uc010zgi.1_Missense_Mutation_p.K78N|GLS_uc010zgj.1_Missense_Mutation_p.K12N	NM_014905	NP_055720	O94925	GLSK_HUMAN	glutaminase precursor	507					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			ovary(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTCTGGATAAGATGGGCAACA	0.398000													43	43					1.00001e-27	1.11919e-27	0.009718	1	0
SGOL2	151246	broad.mit.edu	37	2	201436531	201436531	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:201436531C>T	uc002uvw.2	+	7	1575	c.1462C>T	c.(1462-1464)CTG>TTG	p.L488L	SGOL2_uc010zhd.1_Silent_p.L488L|SGOL2_uc010zhe.1_Silent_p.L488L	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	488					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						AGAAAATGTACTGTGTAATAA	0.368000													73	92					0	0	0.003610	0	0
CASP8	841	broad.mit.edu	37	2	202131505	202131505	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:202131505C>T	uc002uxr.1	+	3	505	c.296C>T	c.(295-297)TCT>TTT	p.S99F	CASP8_uc010ftc.1_Missense_Mutation_p.S99F|CASP8_uc002uxo.1_Missense_Mutation_p.S99F|CASP8_uc002uxp.1_Missense_Mutation_p.S99F|CASP8_uc002uxq.1_Missense_Mutation_p.S99F|CASP8_uc002uxs.1_Missense_Mutation_p.S99F|CASP8_uc002uxt.1_Missense_Mutation_p.S158F|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.S99F|CASP8_uc002uxw.1_Missense_Mutation_p.S99F|CASP8_uc002uxy.1_Missense_Mutation_p.S99F|CASP8_uc002uxx.1_Missense_Mutation_p.S99F|CASP8_uc010ftf.2_Missense_Mutation_p.S99F	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	99					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GCTCAAATTTCTGCCTACAGG	0.493000										HNSCC(4;0.00038)			14	23					0	0	0.001855	0	0
XRCC5	7520	broad.mit.edu	37	2	217002897	217002897	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:217002897C>T	uc002vfy.2	+	12	1477	c.1337C>T	c.(1336-1338)CCC>CTC	p.P446L	XRCC5_uc002vfz.2_Missense_Mutation_p.P332L	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	446	Ku.				double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		AAATATGCTCCCACCGGTGAG	0.398000								Direct_reversal_of_damage|NHEJ					5	17					0	0	0.000602	0	0
C2orf24	27013	broad.mit.edu	37	2	220039719	220039719	+	Silent	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:220039719C>G	uc002vju.3	-	4	524	c.372G>C	c.(370-372)CTG>CTC	p.L124L	C2orf24_uc002vjv.2_Silent_p.L124L	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	124					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCATGGAGATCAGGAACAAGT	0.547000													13	63					0	0	0.003163	0	0
SPEG	10290	broad.mit.edu	37	2	220333912	220333912	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:220333912G>A	uc010fwg.2	+	13	3526	c.3526G>A	c.(3526-3528)GAG>AAG	p.E1176K		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1176					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CATTCCCGAGGAGCCAGAGCA	0.662000													12	20					0	0	0.001368	0	0
ACCN4	55515	broad.mit.edu	37	2	220379942	220379942	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:220379942C>T	uc002vma.2	+	1	891	c.877C>T	c.(877-879)CTC>TTC	p.L293F	ACCN4_uc010fwi.1_Missense_Mutation_p.L293F|ACCN4_uc010fwj.1_Missense_Mutation_p.L293F|ACCN4_uc002vly.1_Missense_Mutation_p.L293F|ACCN4_uc002vlz.2_Missense_Mutation_p.L293F|ACCN4_uc002vmb.2_5'Flank	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	293	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		GGTAGACATCCTCAACCGCAC	0.612000													11	41					0	0	0.000978	0	0
EPHA4	2043	broad.mit.edu	37	2	222428599	222428599	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:222428599G>A	uc002vmq.2	-	3	717	c.675C>T	c.(673-675)TCC>TCT	p.S225S	EPHA4_uc002vmr.2_Silent_p.S225S|EPHA4_uc010zlm.1_Silent_p.S166S|EPHA4_uc010zln.1_Silent_p.S225S	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	225	Cys-rich.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CTTCCACCAGGGAAGACGTAT	0.512000													25	75					0	0	0.004656	0	0
MFF	56947	broad.mit.edu	37	2	228195474	228195474	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:228195474G>A	uc002vos.2	+	4	589	c.171G>A	c.(169-171)CCG>CCA	p.P57P	MFF_uc002vot.2_Silent_p.P31P|MFF_uc002vou.2_Silent_p.P57P|MFF_uc002vov.2_Silent_p.P31P|MFF_uc002vow.2_Silent_p.P31P|MFF_uc002vox.2_Silent_p.P31P|MFF_uc002voy.2_Silent_p.P57P|MFF_uc002voz.2_Silent_p.P31P	NM_020194	NP_064579	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	57	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane				large_intestine(1)	1						AAGTAGCACCGCCAAACGCTG	0.438000													13	63					0	0	0.001855	0	0
DNER	92737	broad.mit.edu	37	2	230411694	230411694	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:230411694C>T	uc002vpv.2	-	5	1109	c.962G>A	c.(961-963)GGA>GAA	p.G321E	DNER_uc010zly.1_Missense_Mutation_p.G49E	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	321	Extracellular (Potential).|EGF-like 3.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TTTTCCTTTTCCTGAACACTC	0.448000													52	68					0	0	0.003610	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910574	230910574	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:230910574G>A	uc002vqd.1	-	4	1631	c.1268C>T	c.(1267-1269)TCC>TTC	p.S423F	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Missense_Mutation_p.S423F|SLC16A14_uc002vqf.2_Missense_Mutation_p.S423F	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	423	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		GGGCATTAGGGAGAAATAACC	0.502000													23	27					0	0	0.004656	0	0
SP140	11262	broad.mit.edu	37	2	231110646	231110646	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:231110646G>A	uc002vql.2	+	7	848	c.733G>A	c.(733-735)GAT>AAT	p.D245N	SP140_uc010zma.1_Intron|SP140_uc002vqk.2_Missense_Mutation_p.D245N|SP140_uc002vqn.2_Missense_Mutation_p.D242N|SP140_uc002vqm.2_Intron|SP140_uc010fxl.2_Missense_Mutation_p.D245N	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	245					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		ACTGCCTTATGATACAGAAGG	0.343000													6	22					0	0	0.001168	0	0
SP140	11262	broad.mit.edu	37	2	231155249	231155249	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:231155249G>A	uc002vql.2	+	19	1910	c.1795G>A	c.(1795-1797)GGA>AGA	p.G599R	SP140_uc010zma.1_RNA|SP140_uc002vqn.2_Missense_Mutation_p.G485R|SP140_uc002vqm.2_Missense_Mutation_p.G539R|SP140_uc010fxl.2_Missense_Mutation_p.G572R	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	599	SAND.				defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TGGGGTGAAGGGAATTTTACA	0.403000													14	48					0	0	0.003163	0	0
USP40	55230	broad.mit.edu	37	2	234465632	234465632	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:234465632G>A	uc010zmu.1	-	5	533	c.415C>T	c.(415-417)CGA>TGA	p.R139*	USP40_uc010zmr.1_Nonsense_Mutation_p.R151*			Q9NVE5	UBP40_HUMAN	SubName: Full=cDNA FLJ56772, highly similar to Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15);	139					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		AAGAGGATTCGATTCAGTTCC	0.388000													21	27					0	0	0.002299	0	0
UGT1A6	54578	broad.mit.edu	37	2	234602101	234602101	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:234602101C>T	uc002vuv.3	+	1	590	c.451C>T	c.(451-453)CCA>TCA	p.P151S	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Missense_Mutation_p.P151S	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	151					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		TTTCACAGACCCAGCCTTACC	0.512000													20	84					0	0	0.008871	0	0
SIRPB1	10326	broad.mit.edu	37	20	1552525	1552525	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr20:1552525C>T	uc010gai.2	-	3	691	c.592G>A	c.(592-594)GAC>AAC	p.D198N	SIRPB1_uc002wfk.3_Intron	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	198	Ig-like C1-type 1.|Extracellular (Potential).				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						CCTGCGGGGTCCACGTTGGTC	0.557000													45	75					0	0	0.003610	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3682274	3682274	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr20:3682274G>A	uc002wja.2	-	6	1243	c.1243C>T	c.(1243-1245)CCA>TCA	p.P415S	SIGLEC1_uc002wiz.3_Missense_Mutation_p.P415S	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	415	Ig-like C2-type 4.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GTCAGGACTGGAGTGAGAGGC	0.617000													19	21					0	0	0.007413	0	0
PLCB4	5332	broad.mit.edu	37	20	9449296	9449296	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr20:9449296C>G	uc002wnf.2	+	34	3427	c.3291C>G	c.(3289-3291)ATC>ATG	p.I1097M	PLCB4_uc010gbx.2_Missense_Mutation_p.I1109M|PLCB4_uc002wne.2_Missense_Mutation_p.I1097M|PLCB4_uc002wnh.2_Missense_Mutation_p.I944M	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	1097					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						ATAAATCTATCAAGAATAAAG	0.388000													9	87					0	0	0.004482	0	0
KIF16B	55614	broad.mit.edu	37	20	16355048	16355048	+	Silent	SNP	T	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr20:16355048T>C	uc002wpg.1	-	20	3362	c.3204A>G	c.(3202-3204)GAA>GAG	p.E1068E	KIF16B_uc002wpe.1_Silent_p.E450E|KIF16B_uc002wpf.1_Silent_p.E450E|KIF16B_uc010gch.1_Intron|KIF16B_uc010gci.1_Silent_p.E1068E	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	1068	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						GGATTTCATATTCTAACCTAC	0.289000													35	74					0	0	0.005524	0	0
PTPRT	11122	broad.mit.edu	37	20	40827898	40827898	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr20:40827898G>A	uc002xkg.2	-	16	2657	c.2473C>T	c.(2473-2475)CAG>TAG	p.Q825*	PTPRT_uc010ggj.2_Nonsense_Mutation_p.Q844*|PTPRT_uc010ggi.2_Nonsense_Mutation_p.Q28*	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	825	Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TTGACGTCCTGAGAACTAGAA	0.567000													164	333					0	0	0.003610	0	0
CDH4	1002	broad.mit.edu	37	20	60504712	60504712	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr20:60504712G>A	uc002ybn.1	+	13	2065	c.2051G>A	c.(2050-2052)GGG>GAG	p.G684E	CDH4_uc002ybp.1_Missense_Mutation_p.G610E	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	684	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CTGGAGGCCGGGATGTATGAC	0.552000													45	55					0	0	0.003610	0	0
GMEB2	26205	broad.mit.edu	37	20	62221685	62221685	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr20:62221685G>A	uc002yfp.1	-	9	1829	c.1350C>T	c.(1348-1350)GAC>GAT	p.D450D	GMEB2_uc002yfo.1_Silent_p.D372D|GMEB2_uc002yfq.1_Silent_p.D450D	NM_012384	NP_036516	Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding	450					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding				0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			GGCTGGACGCGTCCGGGTGGA	0.697000													5	28					0	0	0.000602	0	0
C21orf99	149992	broad.mit.edu	37	21	14417545	14417545	+	RNA	SNP	T	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr21:14417545T>C	uc002yiy.3	+	3		c.2820T>C			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						GTGGAATTTTTACTGACAAAA	0.299000													3	8					0	0	0.004672	0	0
C21orf81	391267	broad.mit.edu	37	21	15326429	15326429	+	RNA	SNP	A	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr21:15326429A>T	uc002yji.2	-	2		c.786T>A				NR_027270				Homo sapiens C21orf81 protein (C21orf81) mRNA, complete cds.												0						TTTCCATGGGAAGGTCCACGT	0.323000													23	62					0	0	0.007291	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28338578	28338578	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr21:28338578G>A	uc002ymg.2	-	1	862	c.133C>T	c.(133-135)CGG>TGG	p.R45W		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	45					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CCCTGCCGCCGGCGGGGCTGG	0.766000													7	11					0	0	0.001984	0	0
KCNJ6	3763	broad.mit.edu	37	21	39087108	39087108	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr21:39087108G>A	uc011aej.1	-	3	405	c.352C>T	c.(352-354)CGG>TGG	p.R118W	KCNJ6_uc002ywo.2_Missense_Mutation_p.R118W	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	118	Extracellular (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	ATGTCTCCCCGTATGTATGCG	0.453000													19	83					0	0	0.010504	0	0
PCP4	5121	broad.mit.edu	37	21	41300949	41300949	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr21:41300949G>A	uc002yyp.2	+	3	183	c.102G>A	c.(100-102)ATG>ATA	p.M34I		NM_006198	NP_006189	P48539	PCP4_HUMAN	Purkinje cell protein 4	34					central nervous system development	cytosol|nucleus				large_intestine(1)	1		Prostate(19;2.65e-06)|all_epithelial(19;0.138)				ACATTGACATGGATGCACCAG	0.463000													19	48					0	0	0.008871	0	0
DSCAM	1826	broad.mit.edu	37	21	41423967	41423967	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr21:41423967C>T	uc002yyq.1	-	30	5555	c.5103G>A	c.(5101-5103)ACG>ACA	p.T1701T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1701	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGTGAGTGACCGTCAGGGACT	0.547000													40	64					0	0	0.006230	0	0
DSCAM	1826	broad.mit.edu	37	21	42080602	42080602	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr21:42080602G>A	uc002yyq.1	-	2	591	c.139C>T	c.(139-141)CCC>TCC	p.P47S	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	47	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCTGCTGCGGGGCAGGGCACC	0.592000													54	91					0	0	0.003610	0	0
UMODL1	89766	broad.mit.edu	37	21	43547871	43547871	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr21:43547871A>T	uc002zaf.1	+	20	3620	c.3620A>T	c.(3619-3621)AAC>ATC	p.N1207I	UMODL1_uc002zad.1_Missense_Mutation_p.N1135I|UMODL1_uc002zae.1_Missense_Mutation_p.N1263I|UMODL1_uc002zag.1_Missense_Mutation_p.N1335I|UMODL1_uc002zal.1_Missense_Mutation_p.N157I|UMODL1_uc010gpa.1_RNA	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	1207	Extracellular (Potential).|ZP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TCCTTTATCAACGACTCCATC	0.488000													12	61					0	0	0.001855	0	0
ABCG1	9619	broad.mit.edu	37	21	43645804	43645804	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr21:43645804G>A	uc002zaq.2	+	2	172	c.66G>A	c.(64-66)GAG>GAA	p.E22E	ABCG1_uc002zan.2_Silent_p.E24E|ABCG1_uc002zam.2_5'UTR|ABCG1_uc002zao.2_Silent_p.E19E|ABCG1_uc002zap.2_Silent_p.E22E|ABCG1_uc002zar.2_Silent_p.E33E|ABCG1_uc011aev.1_Silent_p.E33E	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	22	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	ACTCTGCAGAGATGACGGAGC	0.483000													31	86					0	0	0.002096	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458067	20458067	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr22:20458067C>A	uc002zsd.3	-	1	3720	c.3235G>T	c.(3235-3237)GAC>TAC	p.D1079Y		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			AAGAGTGTGTCGAAGGTGACG	0.657000													5	47					0.000602214	0.000640477	0.000602	1	0
CCDC116	164592	broad.mit.edu	37	22	21989511	21989511	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr22:21989511C>T	uc002zve.2	+	4	1252	c.1159C>T	c.(1159-1161)CCC>TCC	p.P387S	CCDC116_uc011aih.1_Missense_Mutation_p.P387S	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	387										ovary(1)|skin(1)	2	Colorectal(54;0.105)					AGGAGGCTCCCCCTCCATGTC	0.607000													7	21					0	0	0.003080	0	0
SEC14L3	266629	broad.mit.edu	37	22	30860877	30860877	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr22:30860877G>A	uc003ahy.2	-	8	683	c.594C>T	c.(592-594)TTC>TTT	p.F198F	SEC14L3_uc003ahz.2_Silent_p.F121F|SEC14L3_uc003aia.2_Silent_p.F139F|SEC14L3_uc003aib.2_Silent_p.F139F	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	198	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	AGCCCACAGGGAACAGTTTGG	0.448000													53	59					0	0	0.003610	0	0
MYH9	4627	broad.mit.edu	37	22	36689888	36689888	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr22:36689888C>T	uc003apg.2	-	29	4090	c.3859G>A	c.(3859-3861)GGG>AGG	p.G1287R		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1287	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CTGAGAAGCCCGGTCACGTTG	0.632000			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				7	21					0	0	0.001984	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713657	30713657	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:30713657C>T	uc003ceo.2	+	4	1364	c.982C>T	c.(982-984)CAC>TAC	p.H328Y	TGFBR2_uc003cen.2_Missense_Mutation_p.H353Y	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	328	Protein kinase.|Cytoplasmic (Potential).		H -> Y (in a lung neuroendocrine carcinoma sample; somatic mutation).		activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding	p.H328Y(1)		pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CACCGCCTTCCACGCCAAGGG	0.587000													37	47					0	0	0.004289	0	0
TRANK1	9881	broad.mit.edu	37	3	36873681	36873681	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:36873681C>T	uc003cgj.2	-	12	5913	c.5611G>A	c.(5611-5613)GTG>ATG	p.V1871M		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2421					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GCCAGCACCACCCCACAGTGG	0.512000													26	93					0	0	0.002096	0	0
DLEC1	9940	broad.mit.edu	37	3	38138146	38138146	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:38138146C>T	uc003cho.1	+	15	2279	c.2258C>T	c.(2257-2259)CCT>CTT	p.P753L	DLEC1_uc003chp.1_Missense_Mutation_p.P753L|DLEC1_uc010hgv.1_Missense_Mutation_p.P753L|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	753					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		TCAGTAGAACCTTTCCAGGTT	0.483000													36	89					0	0	0.004289	0	0
SCN10A	6336	broad.mit.edu	37	3	38793930	38793930	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:38793930C>T	uc003ciq.2	-	11	1535	c.1535G>A	c.(1534-1536)CGA>CAA	p.R512Q		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	512					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGAGATATCTCGGCCAGGGGA	0.587000													9	45					0	0	0.000978	0	0
ANO10	55129	broad.mit.edu	37	3	43474171	43474171	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:43474171T>C	uc003cmv.2	-	12	2017	c.1846A>G	c.(1846-1848)AAG>GAG	p.K616E	ANO10_uc011azs.1_Intron|ANO10_uc003cmw.2_Missense_Mutation_p.K550E|ANO10_uc010hil.2_Missense_Mutation_p.K426E|ANO10_uc011azt.1_Missense_Mutation_p.K505E	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	616	Cytoplasmic (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						TGCCGTGGCTTATCAGGTATG	0.423000													17	33					0	0	0.004990	0	0
NBEAL2	23218	broad.mit.edu	37	3	47049364	47049364	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:47049364G>A	uc003cqp.2	+	49	7745	c.7566G>A	c.(7564-7566)CGG>CGA	p.R2522R	NBEAL2_uc010hjm.1_Silent_p.R1899R|NBEAL2_uc010hjn.1_Silent_p.R888R|NBEAL2_uc010hjo.1_Silent_p.R82R	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2522	WD 3.						binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CAGGCTCCCGGGACACCACGT	0.632000													7	21					0	0	0.003080	0	0
STAB1	23166	broad.mit.edu	37	3	52557513	52557513	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:52557513G>A	uc003dej.2	+	65	7285	c.7211G>A	c.(7210-7212)GGG>GAG	p.G2404E	STAB1_uc003dek.1_Missense_Mutation_p.G419E|STAB1_uc003del.2_Missense_Mutation_p.G291E	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2404	Extracellular (Potential).|FAS1 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCCAGCCAGGGGAAGTTGCTT	0.632000													21	26					0	0	0.010504	0	0
VGLL3	389136	broad.mit.edu	37	3	87027686	87027686	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:87027686G>A	uc003dqn.2	-	2	757	c.393C>T	c.(391-393)CCC>CCT	p.P131P		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CTCGCCATAGGGGGGTTAGCC	0.512000													23	78					0	0	0.003954	0	0
RG9MTD1	54931	broad.mit.edu	37	3	101284693	101284693	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:101284693G>A	uc003duz.2	+	2	1216	c.1068G>A	c.(1066-1068)ATG>ATA	p.M356I		NM_017819	NP_060289	Q7L0Y3	MRRP1_HUMAN	RNA (guanine-9-) methyltransferase domain	356					tRNA processing	mitochondrion	methyltransferase activity|protein binding			ovary(1)	1						TAGATCAAATGATACGTATTT	0.378000													8	28					0	0	0.004482	0	0
ZBTB20	26137	broad.mit.edu	37	3	114057948	114057948	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:114057948C>T	uc003ebi.2	-	5	2310	c.2130G>A	c.(2128-2130)ACG>ACA	p.T710T	ZBTB20_uc003ebj.2_Silent_p.T637T|ZBTB20_uc010hqp.2_Silent_p.T637T|ZBTB20_uc003ebk.2_Silent_p.T637T|ZBTB20_uc003ebl.2_Silent_p.T637T|ZBTB20_uc003ebm.2_Silent_p.T637T|ZBTB20_uc003ebn.2_Silent_p.T637T	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	710					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		TGGTCCCCTCCGTGCAGGCCA	0.632000													24	31					0	0	0.002299	0	0
FBXO40	51725	broad.mit.edu	37	3	121340282	121340282	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:121340282G>A	uc003eeg.2	+	3	216	c.6G>A	c.(4-6)GGG>GGA	p.G2G		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	2					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		GTGTCCAGGGGAAAGCCCGCA	0.507000													45	65					0	0	0.003610	0	0
FBXO40	51725	broad.mit.edu	37	3	121341342	121341342	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:121341342T>C	uc003eeg.2	+	3	1276	c.1066T>C	c.(1066-1068)TAC>CAC	p.Y356H		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	356					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		TCCTGTGAGCTACTGTGGAAA	0.478000													38	41					0	0	0.004289	0	0
HEG1	57493	broad.mit.edu	37	3	124720797	124720797	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:124720797G>A	uc003ehs.3	-	11	3484	c.3416C>T	c.(3415-3417)ACG>ATG	p.T1139M	HEG1_uc003ehr.3_Translation_Start_Site|HEG1_uc011bke.1_Missense_Mutation_p.T1239M	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	1139	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GTCAAATAGCGTCACATTGGA	0.498000													11	23					0	0	0.000978	0	0
MED12L	116931	broad.mit.edu	37	3	150840679	150840679	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:150840679T>G	uc003eyp.2	+	3	352	c.314T>G	c.(313-315)GTT>GGT	p.V105G	MED12L_uc011bnz.1_Missense_Mutation_p.V105G|MED12L_uc003eym.1_Missense_Mutation_p.V105G|MED12L_uc003eyn.2_Missense_Mutation_p.V105G|MED12L_uc003eyo.2_Missense_Mutation_p.V105G	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	105					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TATTGGCTGGTTACTGCTCGA	0.363000													8	13					0	0	0.004482	0	0
SERPINI1	5274	broad.mit.edu	37	3	167506979	167506979	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:167506979C>T	uc003ffa.3	+	2	261	c.63C>T	c.(61-63)TTC>TTT	p.F21F	SERPINI1_uc003ffb.3_Silent_p.F21F	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	21					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						GGGCCACTTTCCCTGAGGAAG	0.408000													31	32					0	0	0.002096	0	0
ECE2	9718	broad.mit.edu	37	3	183967668	183967668	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:183967668C>T	uc003fni.3	+	1	224	c.186C>T	c.(184-186)ATC>ATT	p.I62I	ALG3_uc003fne.2_5'Flank|ALG3_uc011brc.1_5'Flank|ALG3_uc011brd.1_5'Flank|ALG3_uc011bre.1_5'Flank|ALG3_uc003fnf.1_5'Flank|ALG3_uc011brf.1_5'Flank|ECE2_uc003fnh.3_Silent_p.I62I	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	62	Cytoplasmic (Potential).|Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGACCGTATCCTTGTGCTAG	0.677000											OREG0015944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	43					0	0	0.007291	0	0
CLCN2	1181	broad.mit.edu	37	3	184070900	184070900	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr3:184070900C>T	uc003foi.2	-	18	2188	c.2064G>A	c.(2062-2064)CGG>CGA	p.R688R	CLCN2_uc003foh.2_Silent_p.R212R|CLCN2_uc010hya.1_Silent_p.R671R|CLCN2_uc011brl.1_Silent_p.R688R|CLCN2_uc011brm.1_Silent_p.R644R	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	688	Cytoplasmic (By similarity).					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	GGGTCTCCCCCCGGGCTGCTG	0.617000													76	107					0	0	0.003610	0	0
EVC2	132884	broad.mit.edu	37	4	5624705	5624705	+	Missense_Mutation	SNP	C	T	T	rs144420242	byFrequency	TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:5624705C>T	uc003gij.2	-	14	2114	c.2060G>A	c.(2059-2061)CGT>CAT	p.R687H	EVC2_uc011bwb.1_Missense_Mutation_p.R127H|EVC2_uc003gik.2_Missense_Mutation_p.R607H	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	687	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						CTGCTCCCTACGCTGCTCCCT	0.592000													19	34					0	0	0.006122	0	0
ACOX3	8310	broad.mit.edu	37	4	8418200	8418200	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:8418200G>A	uc010idk.2	-	2	194	c.49C>T	c.(49-51)CCC>TCC	p.P17S	ACOX3_uc003glc.3_Missense_Mutation_p.P17S|ACOX3_uc003gld.3_Missense_Mutation_p.P17S|ACOX3_uc003gle.1_5'Flank	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	17					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						GGCCCCCTGGGGAATTCTGGG	0.587000													12	41					0	0	0.000978	0	0
KCNIP4	80333	broad.mit.edu	37	4	20734378	20734378	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:20734378C>T	uc003gqe.2	-	6	601	c.517G>A	c.(517-519)GAT>AAT	p.D173N	KCNIP4_uc003gqf.1_Missense_Mutation_p.D169N|KCNIP4_uc003gqg.1_Missense_Mutation_p.D128N|KCNIP4_uc003gqh.1_Missense_Mutation_p.D165N|KCNIP4_uc003gqi.1_Missense_Mutation_p.D128N|PACRGL_uc003gpu.2_Intron|PACRGL_uc003gpx.3_Intron|PACRGL_uc003gpw.2_Intron|KCNIP4_uc010iel.2_Missense_Mutation_p.D170N|KCNIP4_uc003gqd.3_Missense_Mutation_p.D153N	NM_147182	NP_671711	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4 isoform 3	190	EF-hand 3.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)				CCCATCATATCGTATATTGCT	0.378000													7	31					0	0	0.004482	0	0
PI4K2B	55300	broad.mit.edu	37	4	25265404	25265404	+	Silent	SNP	T	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:25265404T>C	uc003grk.2	+	7	1144	c.1011T>C	c.(1009-1011)CTT>CTC	p.L337L	PI4K2B_uc011bxs.1_Silent_p.L241L	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta	337	PI3K/PI4K.					cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			ovary(2)|skin(2)	4		Breast(46;0.173)				AAGAATTCCTTATTAAAATAG	0.289000													19	83					0	0	0.002299	0	0
RBPJ	3516	broad.mit.edu	37	4	26432080	26432080	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:26432080G>A	uc003grx.1	+	11	1359	c.1123G>A	c.(1123-1125)GGA>AGA	p.G375R	RBPJ_uc003gry.1_Missense_Mutation_p.G360R|RBPJ_uc003grz.1_Missense_Mutation_p.G375R|RBPJ_uc003gsa.1_Missense_Mutation_p.G361R|RBPJ_uc003gsb.1_Missense_Mutation_p.G362R|RBPJ_uc003gsc.1_Intron|uc003gsd.2_5'Flank	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	375	IPT/TIG.				DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				TGAACTTACAGGACAGAATTT	0.383000													34	27					0	0	0.004289	0	0
C4orf19	55286	broad.mit.edu	37	4	37592072	37592072	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:37592072C>A	uc003gsw.3	+	4	578	c.395C>A	c.(394-396)CCA>CAA	p.P132Q	C4orf19_uc003gsy.3_Missense_Mutation_p.P132Q	NM_001104629	NP_001098099	Q8IY42	CD019_HUMAN	hypothetical protein LOC55286	132											0						ACTGTTCCCCCAACTCAACCC	0.597000													38	42					1.67305e-13	1.85626e-13	0.006230	1	0
CENPC1	1060	broad.mit.edu	37	4	68374707	68374707	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:68374707G>A	uc003hdd.1	-	10	1912	c.1729C>T	c.(1729-1731)CCA>TCA	p.P577S	CENPC1_uc010ihj.1_RNA|CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihm.1_Missense_Mutation_p.P577S	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	577					mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2						CTTTTAAGTGGAATAGTTTTT	0.338000													16	80					0	0	0.004007	0	0
PROL1	58503	broad.mit.edu	37	4	71275418	71275418	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:71275418C>T	uc003hfi.2	+	3	547	c.373C>T	c.(373-375)CCT>TCT	p.P125S		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	125	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				ACCCCCATTTCCTCCTATTCC	0.413000													15	96					0	0	0.003163	0	0
AFM	173	broad.mit.edu	37	4	74363443	74363443	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:74363443G>T	uc003hhb.2	+	10	1297	c.1266G>T	c.(1264-1266)TTG>TTT	p.L422F		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	422	Albumin 3.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCCAGAATTTGGGGAAGGATG	0.363000													9	13					6.40141e-05	6.84595e-05	0.000978	1	0
PPEF2	5470	broad.mit.edu	37	4	76788487	76788487	+	Nonsense_Mutation	SNP	T	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:76788487T>A	uc003hix.2	-	14	2092	c.1735A>T	c.(1735-1737)AAG>TAG	p.K579*	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Nonsense_Mutation_p.K579*	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	579	EF-hand 1.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GCATCATGCTTCTTAAATTCA	0.428000													6	33					0	0	0.001984	0	0
SDAD1	55153	broad.mit.edu	37	4	76877281	76877281	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:76877281C>A	uc003hje.3	-	21	1982	c.1863G>T	c.(1861-1863)AAG>AAT	p.K621N	SDAD1_uc003hjf.3_Missense_Mutation_p.K524N|SDAD1_uc011cbr.1_Missense_Mutation_p.K584N	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	621					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTCGGTCTGTCTTTCCAGCCT	0.269000													18	74					4.96729e-08	5.40228e-08	0.008871	1	0
HPSE	10855	broad.mit.edu	37	4	84231203	84231203	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:84231203C>T	uc003hoj.3	-	6	970	c.871G>A	c.(871-873)GAT>AAT	p.D291N	HPSE_uc010ika.2_Missense_Mutation_p.D233N|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.D34N|HPSE_uc011cct.1_Missense_Mutation_p.D291N|HPSE_uc003hok.3_Missense_Mutation_p.D291N	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	291				D -> G (in Ref. 9; BAD96706).	carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	GTAACTGAATCAATCACTTCT	0.308000													58	71					0	0	0.003610	0	0
DSPP	1834	broad.mit.edu	37	4	88534261	88534261	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:88534261A>C	uc003hqu.2	+	4	1043	c.923A>C	c.(922-924)GAA>GCA	p.E308A		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	308					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		TATGACCCTGAAGGCAAAGAA	0.428000													15	19					0	0	0.004990	0	0
C4orf37	285555	broad.mit.edu	37	4	99064228	99064228	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:99064228G>A	uc003htt.1	-	1	164	c.74C>T	c.(73-75)TCC>TTC	p.S25F		NM_174952	NP_777612	Q8N412	CD037_HUMAN	hypothetical protein LOC285555	25											0				OV - Ovarian serous cystadenocarcinoma(123;2.27e-08)		TACCTGGTAGGATCCAGGACC	0.597000											OREG0016268	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	18					0	0	0.001368	0	0
GSTCD	79807	broad.mit.edu	37	4	106640672	106640672	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:106640672C>T	uc003hxz.3	+	3	954	c.882C>T	c.(880-882)ATC>ATT	p.I294I	GSTCD_uc003hxx.2_Silent_p.I294I|GSTCD_uc003hxy.3_Silent_p.I207I|GSTCD_uc011cfb.1_Intron|GSTCD_uc010ils.1_Silent_p.I294I	NM_001031720	NP_001026890	Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain	294	GST C-terminal.					cytoplasm	rRNA methyltransferase activity			breast(1)|central_nervous_system(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)		TGCCCTGTATCCATCATTTCT	0.353000													33	30					0	0	0.003271	0	0
DKK2	27123	broad.mit.edu	37	4	107845814	107845814	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:107845814G>A	uc003hyi.2	-	3	1122	c.417C>T	c.(415-417)ATC>ATT	p.I139I	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Silent_p.I139I	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	139					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CCAGAGCCGGGATGTGAGGGG	0.428000													21	78					0	0	0.002780	0	0
ANK2	287	broad.mit.edu	37	4	114277622	114277622	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:114277622A>C	uc003ibe.3	+	38	7948	c.7848A>C	c.(7846-7848)AAA>AAC	p.K2616N	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Intron|ANK2_uc011cgb.1_Missense_Mutation_p.K2631N	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2583					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGAACCCAAACAAGAAGAAT	0.403000													22	66					0	0	0.002780	0	0
FHDC1	85462	broad.mit.edu	37	4	153895901	153895901	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:153895901C>T	uc003inf.2	+	11	1533	c.1458C>T	c.(1456-1458)TCC>TCT	p.S486S		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	486					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					AGCAGCGCTCCTGGGCAACTG	0.632000													13	43					0	0	0.003163	0	0
GRIA2	2891	broad.mit.edu	37	4	158234028	158234028	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:158234028G>A	uc003ipm.3	+	4	1125	c.666_splice	c.e4+1	p.Q222_splice	GRIA2_uc011cit.1_Splice_Site_p.Q175_splice|GRIA2_uc003ipl.3_Splice_Site_p.Q222_splice|GRIA2_uc003ipk.3_Splice_Site_p.Q175_splice|GRIA2_uc010iqh.1_Splice_Site	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2						synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TGTAGACCAGGTTTGCTACTT	0.378000													13	55					0	0	0.001855	0	0
CASP3	836	broad.mit.edu	37	4	185550459	185550459	+	Silent	SNP	G	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr4:185550459G>T	uc003iwh.2	-	8	1064	c.801C>A	c.(799-801)TCC>TCA	p.S267S	CASP3_uc003iwg.2_3'UTR|CASP3_uc003iwi.2_Silent_p.S267S	NM_004346	NP_004337	P42574	CASP3_HUMAN	caspase 3 preproprotein	267					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|negative regulation of apoptosis|nerve growth factor receptor signaling pathway|nuclear fragmentation involved in apoptotic nuclear change|proteolysis|response to tumor necrosis factor	cytosol|mitochondrion|nucleoplasm|plasma membrane	cysteine-type endopeptidase activity|protein binding			kidney(1)	1		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.057)|all_hematologic(60;0.0592)		all cancers(43;2.05e-27)|Epithelial(43;4.27e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.04e-11)|Colorectal(24;2e-05)|STAD - Stomach adenocarcinoma(60;2.35e-05)|GBM - Glioblastoma multiforme(59;4.94e-05)|COAD - Colon adenocarcinoma(29;0.00017)|BRCA - Breast invasive adenocarcinoma(30;0.000218)|LUSC - Lung squamous cell carcinoma(40;0.00904)|READ - Rectum adenocarcinoma(43;0.161)	Melatonin(DB01065)|Minocycline(DB01017)|Simvastatin(DB00641)	TTGTGAGCATGGAAACAATAC	0.368000													21	123					1.9806e-07	2.14797e-07	0.002299	1	0
SDHAP3	728609	broad.mit.edu	37	5	1576305	1576305	+	RNA	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:1576305C>T	uc011cmd.1	-	2		c.424G>A			SDHAP3_uc011cme.1_RNA					Homo sapiens cDNA FLJ58919 complete cds, moderately similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC1.3.5.1).												0						TTGTAGCCTTCCCTGGCGTGC	0.627000													9	21					0	0	0.008291	0	0
DNAH5	1767	broad.mit.edu	37	5	13864629	13864629	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:13864629C>T	uc003jfd.2	-	28	4515	c.4473G>A	c.(4471-4473)ATG>ATA	p.M1491I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1491	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCCGCTCCATCATGGCTTTAC	0.502000									Kartagener_syndrome				8	36					0	0	0.003080	0	0
CDH12	1010	broad.mit.edu	37	5	21752058	21752058	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:21752058C>T	uc010iuc.2	-	12	2631	c.2173G>A	c.(2173-2175)GAT>AAT	p.D725N	CDH12_uc011cno.1_Missense_Mutation_p.D685N|CDH12_uc003jgk.2_Missense_Mutation_p.D725N|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	725	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GGATCCACATCATTTTCCTGT	0.483000										HNSCC(59;0.17)			37	52					0	0	0.003755	0	0
SGTB	54557	broad.mit.edu	37	5	65008804	65008804	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:65008804G>A	uc003jud.2	-	3	408	c.188C>T	c.(187-189)ACC>ATC	p.T63I		NM_019072	NP_061945	Q96EQ0	SGTB_HUMAN	small glutamine-rich tetratricopeptide repeat	63							binding				0		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Breast(144;0.174)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0657)|Lung(70;0.00487)		GAAGGAACTGGTAAACATTTC	0.348000													18	29					0	0	0.008871	0	0
BDP1	55814	broad.mit.edu	37	5	70806692	70806692	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:70806692G>T	uc003kbp.1	+	17	4036	c.3773G>T	c.(3772-3774)GGA>GTA	p.G1258V	BDP1_uc003kbn.1_Missense_Mutation_p.G1258V|BDP1_uc003kbo.2_Missense_Mutation_p.G1258V	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1258	Potential.|9; approximate.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AAAGAAACTGGAAAAAGAGAC	0.358000													27	157					9.8876e-21	1.1034e-20	0.004878	1	0
SPOCK1	6695	broad.mit.edu	37	5	136320844	136320844	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:136320844C>T	uc003lbo.2	-	8	1167	c.976G>A	c.(976-978)GGG>AGG	p.G326R	SPOCK1_uc003lbp.2_Missense_Mutation_p.G326R	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	326	Thyroglobulin type-1.				cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGGCTTTTCCCCTTACTCAGC	0.393000													26	50					0	0	0.004656	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203277	140203277	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:140203277C>T	uc003lhl.2	+	1	1917	c.1917C>T	c.(1915-1917)ACC>ACT	p.T639T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.T639T|PCDHA5_uc003lhj.1_Silent_p.T639T	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	639	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGATGAGACCGAAGCACCGC	0.642000													20	42					0	0	0.010504	0	0
PCDHA8	56140	broad.mit.edu	37	5	140223009	140223009	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:140223009C>T	uc003lhs.2	+	1	2103	c.2103C>T	c.(2101-2103)ATC>ATT	p.I701I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.I701I	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	701	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTACCTGATCATCGCCATCT	0.662000													35	78					0	0	0.004878	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140358562	140358562	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:140358562A>C	uc003lii.2	+	2	2834	c.2594A>C	c.(2593-2595)TAC>TCC	p.Y865S	PCDHA1_uc003lha.2_Missense_Mutation_p.Y544S|PCDHA1_uc003lhb.2_Missense_Mutation_p.Y808S|PCDHA2_uc003lhd.2_Missense_Mutation_p.Y806S|PCDHA3_uc003lhf.2_Missense_Mutation_p.Y808S|PCDHA4_uc003lhi.2_Missense_Mutation_p.Y805S|PCDHA4_uc003lhh.1_Missense_Mutation_p.Y805S|PCDHA5_uc003lhk.1_Missense_Mutation_p.Y794S|PCDHA5_uc003lhl.2_Missense_Mutation_p.Y794S|PCDHA6_uc003lhn.2_Missense_Mutation_p.Y544S|PCDHA6_uc003lho.2_Missense_Mutation_p.Y808S|PCDHA7_uc003lhq.2_Missense_Mutation_p.Y795S|PCDHA8_uc003lhs.2_Missense_Mutation_p.Y808S|PCDHA9_uc003lhu.2_Missense_Mutation_p.Y808S|PCDHA10_uc003lhw.2_Missense_Mutation_p.Y543S|PCDHA10_uc003lhx.2_Missense_Mutation_p.Y806S|PCDHA11_uc003lia.2_Missense_Mutation_p.Y807S|PCDHA12_uc003lic.2_Missense_Mutation_p.Y799S|PCDHA13_uc003lie.1_Missense_Mutation_p.Y808S|PCDHA13_uc003lif.2_Missense_Mutation_p.Y808S|PCDHAC1_uc003lih.2_Missense_Mutation_p.Y821S	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	865	4 X 4 AA repeats of P-X-X-P.|Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACTGGCGTTACTCTGCCTCC	0.458000													16	63					0	0	0.004990	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581472	140581472	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:140581472G>C	uc003liy.2	+	1	2125	c.2125G>C	c.(2125-2127)GTG>CTG	p.V709L	PCDHB11_uc011daj.1_Missense_Mutation_p.V344L	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	709	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCCTGTTCGTGGCGGTGCG	0.687000													20	156					0	0	0.002299	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147040720	147040720	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:147040720C>T	uc003loq.1	-	3	800	c.418G>A	c.(418-420)GAG>AAG	p.E140K	JAKMIP2_uc011dbx.1_Missense_Mutation_p.E98K|JAKMIP2_uc003lor.1_Missense_Mutation_p.E140K|uc003lop.1_3'UTR|JAKMIP2_uc010jgo.1_Missense_Mutation_p.E140K	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	140						Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCGGGCCTCCTCCCGGGCC	0.557000													26	110					0	0	0.005443	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148691727	148691727	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:148691727C>T	uc003lqh.2	+	9	1111	c.980C>T	c.(979-981)CCC>CTC	p.P327L	AFAP1L1_uc003lqg.3_Missense_Mutation_p.P327L|AFAP1L1_uc010jgy.2_Missense_Mutation_p.P327L	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	327							protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGAGGTCCCCAGATCCCCA	0.587000													16	94					0	0	0.006122	0	0
ARSI	340075	broad.mit.edu	37	5	149676950	149676950	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr5:149676950G>A	uc003lrv.2	-	2	2126	c.1537C>T	c.(1537-1539)CCT>TCT	p.P513S		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	513						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTAAAGTCAGGATGAGCCCGG	0.637000													62	84					0	0	0.003610	0	0
PRSS16	10279	broad.mit.edu	37	6	27216906	27216906	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:27216906G>A	uc003nja.2	+	4	377	c.365G>A	c.(364-366)TGG>TAG	p.W122*	PRSS16_uc011dkt.1_Intron|PRSS16_uc003njb.2_Intron|PRSS16_uc010jqq.1_Nonsense_Mutation_p.W12*|PRSS16_uc010jqr.1_Nonsense_Mutation_p.W12*|PRSS16_uc003njc.1_RNA|PRSS16_uc003njd.2_5'Flank	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	122					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						GCCCCAGCCTGGGGCGCCCTG	0.587000													35	45					0	0	0.003271	0	0
OR2H1	26716	broad.mit.edu	37	6	29430220	29430220	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:29430220G>A	uc003nmi.2	+	3	1117	c.674G>A	c.(673-675)AGG>AAG	p.R225K	OR2H1_uc003nmj.1_Missense_Mutation_p.R225K|OR2H1_uc010jri.1_Missense_Mutation_p.R147K	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCAGTGCTGAGGATTAACTCT	0.532000													56	106					0	0	0.003610	0	0
HLA-DMB	3109	broad.mit.edu	37	6	32906605	32906605	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:32906605C>T	uc003ocl.1	-	2	426	c.193G>A	c.(193-195)GAA>AAA	p.E65K	HLA-DMB_uc003ocj.1_Missense_Mutation_p.E65K|HLA-DMB_uc003ock.1_5'Flank|HLA-DMB_uc010jud.1_5'Flank|HLA-DMB_uc010jue.1_5'Flank|HLA-DMB_uc010juf.1_5'Flank|HLA-DMB_uc011dql.1_Missense_Mutation_p.E65K	NM_002118	NP_002109	P28068	DMB_HUMAN	major histocompatibility complex, class II, DM	65	Beta-1.|Lumenal (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						ACCCCAAATTCGCAAGGGGCC	0.512000													41	75					0	0	0.006999	0	0
DNAH8	1769	broad.mit.edu	37	6	38816575	38816575	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:38816575C>G	uc003ooe.1	+	35	5146	c.4546C>G	c.(4546-4548)CAG>GAG	p.Q1516E		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ACAGCTGCCTCAGGTAAATAT	0.378000													6	94					0	0	0.001168	0	0
KCNK5	8645	broad.mit.edu	37	6	39159037	39159037	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:39159037C>G	uc003oon.2	-	5	1493	c.1129G>C	c.(1129-1131)GTG>CTG	p.V377L		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	377					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						GCCCGTGCCACAGCCTCCTCA	0.612000													12	40					0	0	0.001368	0	0
USP49	25862	broad.mit.edu	37	6	41773651	41773651	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:41773651G>A	uc003ori.2	-	4	1293	c.1071C>T	c.(1069-1071)CTC>CTT	p.L357L		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	357					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GTTCACGGCAGAGGGAAATGT	0.602000													32	76					0	0	0.003271	0	0
RIMS1	22999	broad.mit.edu	37	6	72889559	72889559	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:72889559C>T	uc003pga.2	+	5	830	c.753C>T	c.(751-753)GCC>GCT	p.A251A	RIMS1_uc011dyb.1_5'Flank|RIMS1_uc003pgc.2_5'Flank|RIMS1_uc003pgb.3_5'Flank	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	251					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CGCAGCAAGCCTTGGGGCCTG	0.557000													13	10					0	0	0.001855	0	0
EPHA7	2045	broad.mit.edu	37	6	93956618	93956618	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:93956618C>A	uc003poe.2	-	15	2859	c.2618G>T	c.(2617-2619)TGG>TTG	p.W873L	EPHA7_uc003pof.2_Missense_Mutation_p.W868L|EPHA7_uc011eac.1_Missense_Mutation_p.W869L	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	873	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CTCCTTTTGCCAACAATCCAA	0.428000													34	22					1.62565e-12	1.79849e-12	0.002445	1	0
ARG1	383	broad.mit.edu	37	6	131904498	131904498	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:131904498G>A	uc003qcp.1	+	7	727	c.669G>A	c.(667-669)AAG>AAA	p.K223K	ARG1_uc003qco.1_Intron|ARG1_uc010kfm.1_Silent_p.K231K|MED23_uc003qcq.2_Intron	NM_000045	NP_000036	P05089	ARGI1_HUMAN	arginase 1	223					arginine catabolic process|urea cycle	cytosol	arginase activity			ovary(1)	1	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0106)|OV - Ovarian serous cystadenocarcinoma(155;0.0713)	L-Ornithine(DB00129)	TTAAAAGAAAGAAAAGGCCAA	0.393000													14	43					0	0	0.001855	0	0
VNN2	8875	broad.mit.edu	37	6	133072552	133072552	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:133072552G>A	uc003qdt.2	-	5	943	c.932C>T	c.(931-933)TCG>TTG	p.S311L	VNN2_uc003qds.2_Missense_Mutation_p.S20L|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Missense_Mutation_p.S258L	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	311	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		GTAGGCAAGCGAGGATAGGGG	0.438000													40	30					0	0	0.003214	0	0
SLC22A2	6582	broad.mit.edu	37	6	160645756	160645756	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:160645756C>T	uc003qtf.2	-	10	1752	c.1582G>A	c.(1582-1584)GAA>AAA	p.E528K	SLC22A2_uc003qte.1_Missense_Mutation_p.E528K	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	528	Cytoplasmic (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		TTTTCGGCTTCCTCGATGGTC	0.343000													42	46					0	0	0.002852	0	0
PLG	5340	broad.mit.edu	37	6	161143576	161143576	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:161143576G>A	uc003qtm.3	+	10	1296	c.1233G>A	c.(1231-1233)AAG>AAA	p.K411K		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	411	Kringle 4.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGCACCAGAAGACCCCAGAAA	0.478000													24	17					0	0	0.004656	0	0
UNC93A	54346	broad.mit.edu	37	6	167721377	167721377	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr6:167721377G>A	uc003qvq.2	+	7	1262	c.1087G>A	c.(1087-1089)GTC>ATC	p.V363I	UNC93A_uc003qvr.2_Missense_Mutation_p.V321I	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	363	Helical; (Potential).					integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GGCAGATGCCGTCTGGCAGAC	0.607000													20	10					0	0	0.010504	0	0
FTSJ2	29960	broad.mit.edu	37	7	2275012	2275012	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:2275012G>A	uc003slm.2	-	3	515	c.486C>T	c.(484-486)TTC>TTT	p.F162F	MAD1L1_uc003slh.1_5'Flank|MAD1L1_uc003slf.1_5'Flank|MAD1L1_uc003slg.1_5'Flank|MAD1L1_uc010ksh.1_5'Flank|MAD1L1_uc003sli.1_5'Flank|MAD1L1_uc010ksi.1_5'Flank|MAD1L1_uc010ksj.2_5'Flank|FTSJ2_uc003slk.2_Silent_p.F8F|FTSJ2_uc003sll.2_Silent_p.F8F|FTSJ2_uc003sln.2_RNA|FTSJ2_uc003slo.2_Silent_p.F8F	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	FtsJ homolog 2	162					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		CGAGGTCCCGGAACCCTGTGG	0.572000													17	46					0	0	0.004007	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22202161	22202161	+	Splice_Site	SNP	T	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:22202161T>G	uc003svg.2	-	13	1138	c.825_splice	c.e13-1	p.H275_splice	RAPGEF5_uc011jyl.1_Splice_Site	NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5						nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						GCAGAATAGGTGCAAATGGTT	0.333000													12	17					0	0	0.001855	0	0
CCDC129	223075	broad.mit.edu	37	7	31617677	31617677	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:31617677C>T	uc003tcj.1	+	8	1792	c.799C>T	c.(799-801)CGG>TGG	p.R267W	CCDC129_uc011kad.1_Missense_Mutation_p.R277W|CCDC129_uc003tci.1_Intron|CCDC129_uc011kae.1_Missense_Mutation_p.R293W|CCDC129_uc003tck.1_Missense_Mutation_p.R175W	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	267											0						GAACATCAGGCGGGATTGTAA	0.473000													14	13					0	0	0.001855	0	0
TBX20	57057	broad.mit.edu	37	7	35293197	35293197	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:35293197G>C	uc011kas.1	-	1	46	c.35C>G	c.(34-36)TCC>TGC	p.S12C		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	12						nucleus	DNA binding			central_nervous_system(1)	1						GGCCCGAGAGGAGAGTTGGGG	0.642000													13	48					0	0	0.001855	0	0
PKD1L1	168507	broad.mit.edu	37	7	47840343	47840343	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:47840343T>A	uc003tny.1	-	54	8097	c.8097A>T	c.(8095-8097)AAA>AAT	p.K2699N	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2699	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GGAGGCAGTCTTTTTGGCTTC	0.507000													5	119					0	0	0.001168	0	0
MUC17	140453	broad.mit.edu	37	7	100681386	100681386	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:100681386T>A	uc003uxp.1	+	3	6742	c.6689T>A	c.(6688-6690)ATG>AAG	p.M2230K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2230	Extracellular (Potential).|35.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGCACCATGCCGGTAGTT	0.502000													56	329					0	0	0.003610	0	0
COG5	10466	broad.mit.edu	37	7	106871105	106871105	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:106871105C>T	uc003ved.2	-	18	2678	c.2153G>A	c.(2152-2154)CGA>CAA	p.R718Q	COG5_uc003vec.2_Missense_Mutation_p.R739Q|COG5_uc003vee.2_Missense_Mutation_p.R739Q	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	718					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						ATCAGATACTCGTCTACAGAA	0.388000													22	131					0	0	0.002299	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				186	30					0	0	0.003610	0	0
LOC100124692	100124692	broad.mit.edu	37	7	141896582	141896582	+	RNA	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:141896582C>T	uc003vxa.2	+	13		c.1518C>T				NR_003717				Homo sapiens cDNA FLJ16351 fis, clone TESTI2039060, moderately similar to Maltase-glucoamylase, intestinal.												0						GCATTTTATCCATTTTCCAGA	0.458000													5	24					0	0	0.001168	0	0
OR2F1	26211	broad.mit.edu	37	7	143657103	143657103	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:143657103C>T	uc003wds.1	+	1	84	c.40C>T	c.(40-42)CTC>TTC	p.L14F		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					TGAATTTATTCTCCTCGGCCT	0.448000													242	91					0	0	0.003610	0	0
OR2A5	393046	broad.mit.edu	37	7	143748039	143748039	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:143748039T>C	uc011ktw.1	+	1	545	c.545T>C	c.(544-546)CTG>CCG	p.L182P		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TGTGAAATCCTGTCTGTCCTC	0.567000													136	98					0	0	0.003610	0	0
ZNF212	7988	broad.mit.edu	37	7	148951021	148951021	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:148951021C>G	uc003wfp.2	+	5	1099	c.1003C>G	c.(1003-1005)CTG>GTG	p.L335V		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	335	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			GGCCACACATCTGCGCAGCCA	0.577000													18	56					0	0	0.004990	0	0
ZNF212	7988	broad.mit.edu	37	7	148951046	148951046	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:148951046C>G	uc003wfp.2	+	5	1124	c.1028C>G	c.(1027-1029)TCT>TGT	p.S343C		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			GGGTGGGGGTCTTGTACACCT	0.577000													14	45					0	0	0.001855	0	0
MSR1	4481	broad.mit.edu	37	8	16007770	16007770	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr8:16007770G>A	uc003wwz.2	-	7	1147	c.949C>T	c.(949-951)CGA>TGA	p.R317*	MSR1_uc010lsu.2_Nonsense_Mutation_p.R335*|MSR1_uc003wxa.2_Nonsense_Mutation_p.R317*|MSR1_uc003wxb.2_Nonsense_Mutation_p.R317*|MSR1_uc011kxz.1_Nonsense_Mutation_p.R91*	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	317	Collagen-like.|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		GGGAGTCCTCGACTTCCAGGA	0.358000													17	38					0	0	0.007413	0	0
ADAM18	8749	broad.mit.edu	37	8	39467023	39467023	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr8:39467023G>A	uc003xni.2	+	5	287	c.287G>A	c.(286-288)GGA>GAA	p.G96E	ADAM18_uc003xnh.2_Missense_Mutation_p.G96E|ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.G96E	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	96					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CATTACCAAGGATATGCTGCC	0.328000													14	20					0	0	0.004007	0	0
PRDM14	63978	broad.mit.edu	37	8	70981781	70981781	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr8:70981781G>A	uc003xym.2	-	2	517	c.315C>T	c.(313-315)CCC>CCT	p.P105P		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TGGGGACGTGGGGAATTGGGT	0.637000													11	8					0	0	0.008291	0	0
SNX16	64089	broad.mit.edu	37	8	82736160	82736160	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr8:82736160G>A	uc011lft.1	-	5	985	c.478C>T	c.(478-480)CCA>TCA	p.P160S	SNX16_uc003ycn.2_Missense_Mutation_p.P160S|SNX16_uc003yco.2_Missense_Mutation_p.P131S	NM_022133	NP_071416	P57768	SNX16_HUMAN	sorting nexin 16 isoform a	160	PX.				cell communication|early endosome to late endosome transport|endosome to lysosome transport|protein targeting to lysosome	early endosome membrane|extrinsic to endosome membrane|late endosome membrane|lysosome	identical protein binding|phosphatidylinositol binding			ovary(1)|pancreas(1)	2						CGAAAACCTGGAAACATCTCT	0.328000													9	22					0	0	0.008291	0	0
C8orf47	203111	broad.mit.edu	37	8	99102126	99102126	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr8:99102126G>A	uc003yih.1	+	2	1029	c.881G>A	c.(880-882)GGA>GAA	p.G294E		NM_173549	NP_775820	Q6P6B1	CH047_HUMAN	hypothetical protein LOC203111	294	Glu-rich.										0	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			GAAGGTCCAGGAAACATGGAG	0.433000													11	39					0	0	0.000978	0	0
UBR5	51366	broad.mit.edu	37	8	103359151	103359151	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr8:103359151G>A	uc003ykr.1	-	6	589	c.556C>T	c.(556-558)CCA>TCA	p.P186S	UBR5_uc003yks.1_Missense_Mutation_p.P186S	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	186					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AGCTCCTCTGGAATGACAGAT	0.502000													47	40					0	0	0.003610	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814062	106814062	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr8:106814062C>T	uc003ymd.2	+	8	1775	c.1752C>T	c.(1750-1752)TTC>TTT	p.F584F	ZFPM2_uc011lhs.1_Silent_p.F315F	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	584					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CCCCAGAGTTCCCTAGTGTGT	0.443000													34	136					0	0	0.003755	0	0
SLC30A8	169026	broad.mit.edu	37	8	118184863	118184863	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr8:118184863G>A	uc003yoh.2	+	8	1283	c.1053G>A	c.(1051-1053)ATG>ATA	p.M351I	SLC30A8_uc010mcz.2_Missense_Mutation_p.M302I|SLC30A8_uc011lia.1_Missense_Mutation_p.M302I|SLC30A8_uc003yog.2_Missense_Mutation_p.M302I	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	351	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CCATTCAGATGGAATCTCCAG	0.507000													168	246					0	0	0.003610	0	0
ZFAT	57623	broad.mit.edu	37	8	135614396	135614396	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr8:135614396C>T	uc003yup.2	-	6	1741	c.1566G>A	c.(1564-1566)GAG>GAA	p.E522E	ZFAT_uc003yun.2_Silent_p.E510E|ZFAT_uc003yuo.2_Silent_p.E510E|ZFAT_uc010meh.2_Silent_p.E510E|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.E510E|ZFAT_uc010mej.2_Silent_p.E460E|ZFAT_uc003yur.2_Silent_p.E510E	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	522					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GGAGGGCAAACTCCTCTTCCA	0.612000													8	15					0	0	0.006214	0	0
EPPK1	83481	broad.mit.edu	37	8	144940741	144940741	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr8:144940741C>T	uc003zaa.1	-	2	14704	c.14691G>A	c.(14689-14691)GCG>GCA	p.A4897A		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4897	Plectin 61.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCAGGACGCCCGCGATGCAGC	0.677000													4	105					0	0	0.009096	0	0
SMARCA2	6595	broad.mit.edu	37	9	2123808	2123808	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr9:2123808C>T	uc003zhc.2	+	27	3951	c.3852C>T	c.(3850-3852)ATC>ATT	p.I1284I	SMARCA2_uc003zhd.2_Silent_p.I1284I|SMARCA2_uc010mha.2_Silent_p.I1217I	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1284					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CCTCCTGGATCATTAAGGATG	0.567000													15	10					0	0	0.004007	0	0
SLC1A1	6505	broad.mit.edu	37	9	4567670	4567670	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr9:4567670A>G	uc003zij.1	+	6	721	c.485A>G	c.(484-486)TAC>TGC	p.Y162C	C9orf68_uc003zik.2_Intron	NM_004170	NP_004161	P43005	EAA3_HUMAN	solute carrier family 1, member 1	162	Extracellular (Potential).				D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	AACATGCAGTACAAAACTAAG	0.388000													9	10					0	0	0.008291	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39171442	39171442	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr9:39171442G>A	uc004abi.2	-	8	1496	c.1257C>T	c.(1255-1257)TTC>TTT	p.F419F	CNTNAP3_uc004abj.2_Silent_p.F419F|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Silent_p.F419F|CNTNAP3_uc011lqs.1_Silent_p.F419F|CNTNAP3_uc004abl.1_Silent_p.F331F	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	419	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GAAAGAGGACGAAACTCCCTG	0.483000													31	35					0	0	0.007291	0	0
ABL1	25	broad.mit.edu	37	9	133759737	133759737	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr9:133759737G>A	uc004bzw.2	+	11	2063	c.2060G>A	c.(2059-2061)TGG>TAG	p.W687*	ABL1_uc004bzv.2_Nonsense_Mutation_p.W706*	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	687					actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CCCCACCTGTGGAAGAAGTCC	0.692000			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								13	10					0	0	0.002450	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071340	141071340	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr9:141071340G>A	uc004com.2	+	4	1004	c.743G>A	c.(742-744)CGC>CAC	p.R248H	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TTCCAGGGTCGCATGCCCATG	0.542000													5	86					0	0	0.004482	0	0
ARSE	415	broad.mit.edu	37	X	2853151	2853151	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:2853151A>C	uc004crc.3	-	11	1742	c.1492T>G	c.(1492-1494)TGC>GGC	p.C498G	ARSE_uc011mhi.1_Missense_Mutation_p.C444G|ARSE_uc011mhh.1_Missense_Mutation_p.C523G	NM_000047	NP_000038	P51690	ARSE_HUMAN	arylsulfatase E precursor	498					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			ovary(1)|central_nervous_system(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AAGCACGGGCAGACCTTTCTT	0.522000													13	13					0	0	0.004990	0	0
TLR7	51284	broad.mit.edu	37	X	12904189	12904189	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:12904189C>T	uc004cvc.2	+	3	701	c.562C>T	c.(562-564)CCT>TCT	p.P188S		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	188	LRR 6.|Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	TTATCGAAATCCTTGTTATGT	0.388000													11	59					0	0	0.000978	0	0
MOSPD2	158747	broad.mit.edu	37	X	14930383	14930383	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:14930383G>A	uc004cwi.2	+	10	980	c.892G>A	c.(892-894)GAA>AAA	p.E298K	MOSPD2_uc004cwj.2_Missense_Mutation_p.E235K	NM_152581	NP_689794	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	298						integral to membrane	structural molecule activity			lung(1)	1	Hepatocellular(33;0.183)					TAACCCAACCGAATCTACTTC	0.303000													11	59					0	0	0.000978	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212798	26212798	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:26212798G>A	uc004dbr.2	+	2	984	c.835G>A	c.(835-837)GAT>AAT	p.D279N	MAGEB6_uc010ngc.1_Missense_Mutation_p.D59N	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	279	MAGE.									ovary(3)	3						TCTGAGTGGTGATAATGCGCT	0.547000													30	136					0	0	0.002836	0	0
MAGEB2	4113	broad.mit.edu	37	X	30237430	30237430	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:30237430T>A	uc004dbz.2	+	2	836	c.733T>A	c.(733-735)TGG>AGG	p.W245R		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	245	MAGE.						protein binding			ovary(1)	1						TGGGGAACCCTGGAAGCTCAT	0.498000													15	52					0	0	0.004007	0	0
MID1IP1	58526	broad.mit.edu	37	X	38664492	38664492	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:38664492G>A	uc004dei.3	+	3	717	c.293G>A	c.(292-294)CGC>CAC	p.R98H	MID1IP1_uc010ngz.2_Missense_Mutation_p.R98H|MID1IP1_uc004dej.3_Missense_Mutation_p.R98H	NM_001098790	NP_001092260	Q9NPA3	M1IP1_HUMAN	MID1 interacting G12-like protein	98					lipid biosynthetic process|negative regulation of microtubule depolymerization|positive regulation of fatty acid biosynthetic process|positive regulation of ligase activity|protein polymerization	cytosol|microtubule|nucleus					0						AAGTCCATCCGCAACGACATC	0.657000													15	81					0	0	0.004007	0	0
BCOR	54880	broad.mit.edu	37	X	39930225	39930225	+	Splice_Site	SNP	C	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:39930225C>A	uc004den.3	-	6	3530	c.3238_splice	c.e6+1	p.C1080_splice	BCOR_uc004dep.3_Splice_Site_p.C1080_splice|BCOR_uc004deo.3_Splice_Site_p.C1062_splice|BCOR_uc004dem.3_Splice_Site_p.C1080_splice	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c						heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						GGTTTACTTACATCTCTCACT	0.512000													20	76					3.51602e-12	3.8787e-12	0.008871	1	0
MAOA	4128	broad.mit.edu	37	X	43571120	43571120	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:43571120G>A	uc004dfy.2	+	4	489	c.308G>A	c.(307-309)GGG>GAG	p.G103E	MAOA_uc011mkw.1_5'UTR	NM_000240	NP_000231	P21397	AOFA_HUMAN	monoamine oxidase A	103	Cytoplasmic.				behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			breast(2)|ovary(1)	3					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	ATGTTCTAGGGGAAAACATAT	0.363000													17	112					0	0	0.004990	0	0
ZNF630	57232	broad.mit.edu	37	X	47918858	47918858	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:47918858C>T	uc004div.3	-	5	1225	c.973G>A	c.(973-975)GGA>AGA	p.G325R	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.G201R	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	325	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						AATGCTCTTCCATACTTAGTA	0.438000													15	43					0	0	0.004007	0	0
RIBC1	158787	broad.mit.edu	37	X	53457879	53457879	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:53457879C>T	uc004dsk.2	+	8	1236	c.1083C>T	c.(1081-1083)ATC>ATT	p.I361I		NM_001031745	NP_001026915	Q8N443	RIBC1_HUMAN	RIB43A domain with coiled-coils 1 isoform 1	361											0						ATTCAGTAATCTACACCAATC	0.498000													9	104					0	0	0.000978	0	0
HEPH	9843	broad.mit.edu	37	X	65408329	65408329	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:65408329C>T	uc011moz.1	+	5	823	c.763C>T	c.(763-765)CCT>TCT	p.P255S	HEPH_uc004dwn.2_Missense_Mutation_p.P255S|HEPH_uc004dwo.2_5'UTR|HEPH_uc010nkr.2_Missense_Mutation_p.P255S|HEPH_uc011mpa.1_Missense_Mutation_p.P255S	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	252	Extracellular (Potential).|Plastocyanin-like 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						CTGCTCAGATCCTGCTTCAGT	0.473000													11	29					0	0	0.000978	0	0
ITGB1BP2	26548	broad.mit.edu	37	X	70523327	70523327	+	Silent	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:70523327C>T	uc004dzr.1	+	6	458	c.429C>T	c.(427-429)ATC>ATT	p.I143I	BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_Silent_p.I125I	NM_012278	NP_036410	Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein 2	143					muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)					ACAGTCTGATCCGGACTGGTT	0.502000													14	42					0	0	0.004990	0	0
COL4A5	1287	broad.mit.edu	37	X	107858227	107858227	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:107858227G>A	uc004enz.1	+	30	2684	c.2482G>A	c.(2482-2484)GGG>AGG	p.G828R	COL4A5_uc011mso.1_Missense_Mutation_p.G828R|COL4A5_uc004eob.1_Missense_Mutation_p.G436R	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	828	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						AGGACCACCAGGGATTCCTGG	0.433000									Alport_syndrome_with_Diffuse_Leiomyomatosis				17	45					0	0	0.007413	0	0
ALG13	79868	broad.mit.edu	37	X	110951458	110951458	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:110951458C>A	uc011msy.1	+	4	621	c.587C>A	c.(586-588)CCT>CAT	p.P196H	ALG13_uc011msw.1_Missense_Mutation_p.P118H|ALG13_uc011msx.1_Missense_Mutation_p.P92H|ALG13_uc011msz.1_Missense_Mutation_p.P118H|ALG13_uc011mta.1_Missense_Mutation_p.P92H|ALG13_uc011mtb.1_Missense_Mutation_p.P92H			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	196					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						TTTCCTCTCCCTCTTACCCCC	0.473000													17	39					9.16793e-09	9.99902e-09	0.004990	1	0
STAG2	10735	broad.mit.edu	37	X	123205126	123205126	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:123205126T>A	uc004etz.3	+	24	2825	c.2486T>A	c.(2485-2487)ATT>AAT	p.I829N	STAG2_uc004eua.2_Missense_Mutation_p.I829N|STAG2_uc004eub.2_Missense_Mutation_p.I829N|STAG2_uc004euc.2_Missense_Mutation_p.I829N|STAG2_uc004eud.2_Missense_Mutation_p.I829N|STAG2_uc004eue.2_Missense_Mutation_p.I829N	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	829					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CTCAGCTTTATTTTGGATCAT	0.368000													28	103					0	0	0.007291	0	0
ODZ1	10178	broad.mit.edu	37	X	123518237	123518237	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:123518237C>T	uc004euj.2	-	29	6587	c.6523G>A	c.(6523-6525)GAT>AAT	p.D2175N	ODZ1_uc011muj.1_Missense_Mutation_p.D2181N|ODZ1_uc010nqy.2_Missense_Mutation_p.D2182N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2175	Extracellular (Potential).|YD 18.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CCATTCAGATCGTAACTATAA	0.433000													24	62					0	0	0.002780	0	0
USP26	83844	broad.mit.edu	37	X	132160351	132160351	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:132160351G>A	uc010nrm.1	-	6	2368	c.1898C>T	c.(1897-1899)TCT>TTT	p.S633F	USP26_uc011mvf.1_Missense_Mutation_p.S633F	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	633					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					ATTTGGTTTAGAATTTTTTCC	0.398000													6	28					0	0	0.001168	0	0
MTM1	4534	broad.mit.edu	37	X	149809808	149809808	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:149809808C>T	uc004fef.3	+	8	671	c.595C>T	c.(595-597)CCT>TCT	p.P199S	MTM1_uc011mxx.1_RNA|MTM1_uc011mxy.1_Missense_Mutation_p.P162S|MTM1_uc011mxz.1_Missense_Mutation_p.P84S|MTM1_uc010nte.2_Missense_Mutation_p.P67S	NM_000252	NP_000243	Q13496	MTM1_HUMAN	myotubularin	199	Myotubularin phosphatase.		P -> S (in XCNM).		endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGACACTTACCCTGCTCTTTT	0.423000													21	61					0	0	0.001882	0	0
ATP2B3	492	broad.mit.edu	37	X	152815568	152815568	+	Silent	SNP	C	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:152815568C>A	uc004fht.1	+	10	1773	c.1647C>A	c.(1645-1647)GGC>GGA	p.G549G	ATP2B3_uc004fhs.1_Silent_p.G549G	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	549	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCTGCTGGGCTTCGTCTTGG	0.617000													9	24					0.00448238	0.00474098	0.004482	1	0
PDZD4	57595	broad.mit.edu	37	X	153069986	153069986	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:153069986G>A	uc004fiz.1	-	8	1382	c.1132C>T	c.(1132-1134)CCC>TCC	p.P378S	PDZD4_uc004fiy.1_Missense_Mutation_p.P303S|PDZD4_uc004fix.2_Missense_Mutation_p.P282S|PDZD4_uc004fja.1_Missense_Mutation_p.P384S|PDZD4_uc011mze.1_Missense_Mutation_p.P269S	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	378						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GAGGCCCGGGGAAAGAGGAGG	0.642000													7	30					0	0	0.004482	0	0
RENBP	5973	broad.mit.edu	37	X	153206955	153206955	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:153206955A>C	uc004fjo.1	-	8	1091	c.921T>G	c.(919-921)GAT>GAG	p.D307E	RENBP_uc011mzh.1_3'UTR	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	307					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	AGTTATCAGCATCCTGGAAGT	0.582000													28	95					0	0	0.008361	0	0
DNASE1L1	1774	broad.mit.edu	37	X	153633863	153633863	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:153633863G>A	uc004fks.1	-	2	238	c.47C>T	c.(46-48)GCC>GTC	p.A16V	DNASE1L1_uc004fkt.1_Missense_Mutation_p.A16V|DNASE1L1_uc004fku.1_Missense_Mutation_p.A16V|DNASE1L1_uc004fkv.1_Missense_Mutation_p.A16V|DNASE1L1_uc004fkw.1_Missense_Mutation_p.A16V	NM_006730	NP_006721	P49184	DNSL1_HUMAN	deoxyribonuclease I-like 1 precursor	16					DNA catabolic process	endoplasmic reticulum	DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AAAGGCCTGGGCCCCATTGGC	0.617000													4	9					0	0	0.009096	0	0
F8	2157	broad.mit.edu	37	X	154215575	154215575	+	Silent	SNP	G	A	A			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chrX:154215575G>A	uc004fmt.2	-	5	778	c.607C>T	c.(607-609)CTG>TTG	p.L203L		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	203	F5/8 type A 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TCCTTGGCCAGACTCCCTGAA	0.348000													9	26					0	0	0.006214	0	0
C1orf58	148362	broad.mit.edu	37	1	222902985	222902986	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr1:222902985_222902986delTT	uc001hnq.1	+	10	1175_1176	c.780_781delTT	c.(778-783)ACTTTAfs	p.T260fs	C1orf58_uc010put.1_Frame_Shift_Del_p.T228fs|C1orf58_uc010puu.1_Frame_Shift_Del_p.T260fs|C1orf58_uc010puv.1_Frame_Shift_Del_p.T228fs|uc001hnr.1_RNA	NM_144695	NP_653296	Q5VW32	BROX_HUMAN	Bro1-domain-containing protein	260_261	BRO1.					membrane					0				GBM - Glioblastoma multiforme(131;0.0667)		ATGGTGAGACTTTATTGGCTAG	0.351													149	236	---	---	---	---					
NCL	4691	broad.mit.edu	37	2	232325380	232325394	+	In_Frame_Del	DEL	CTTCCTCCTCCTCTT	-	-	rs140018754		TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr2:232325380_232325394delCTTCCTCCTCCTCTT	uc002vru.2	-	4	938_952	c.797_811delAAGAGGAGGAGGAAG	c.(796-813)GAAGAGGAGGAGGAAGAG>GAG	p.266_271EEEEEE>E	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	266_271	Asp/Glu-rich (acidic).				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		ATTTAAGTACCTTCCTCCTCCTCTTCTTCCTCCTC	0.242													12	89	---	---	---	---					
CDC42EP1	11135	broad.mit.edu	37	22	37964409	37964429	+	In_Frame_Del	DEL	CAGCGCCTGCTGCAAACCCCT	-	-	rs66468174	by1000genomes	TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr22:37964409_37964429delCAGCGCCTGCTGCAAACCCCT	uc003asz.3	+	3	1161_1181	c.758_778delCAGCGCCTGCTGCAAACCCCT	c.(757-780)CCAGCGCCTGCTGCAAACCCCTCA>CCA	p.APAANPS254del		NM_152243	NP_689449	Q00587	BORG5_HUMAN	CDC42 effector protein 1	254_260	6.|8 X 7 AA tandem repeats of [PT]-[AT]-A- [ENT]-[PT]-[PTS]-[AG].				positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding				0	Melanoma(58;0.0574)					GCAAACCCCCCAGCGCCTGCTGCAAACCCCTCAGCACCTGC	0.665													5	3	---	---	---	---					
THSD7A	221981	broad.mit.edu	37	7	11871470	11871481	+	In_Frame_Del	DEL	GCAGCGGCAGCG	-	-			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:11871470_11871481delGCAGCGGCAGCG	uc003ssf.3	-	1	344_355	c.92_103delCGCTGCCGCTGC	c.(91-105)CCGCTGCCGCTGCTC>CTC	p.PLPL31del		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	31_34						integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		agcagcaggagcagcggcagcggcagcggcag	0.453										HNSCC(18;0.044)			4	7	---	---	---	---					
EXOC4	60412	broad.mit.edu	37	7	133041262	133041262	+	Frame_Shift_Del	DEL	T	-	-			TCGA-D3-A3C3-06A-12D-A19A-08	TCGA-D3-A3C3-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	473ea20c-b4b1-4471-afaa-26f1edd826fa	37a990a9-2dbd-4fdd-9b35-a651ca488e61	g.chr7:133041262delT	uc003vrk.2	+	6	977	c.942delT	c.(940-942)TCTfs	p.S314fs	EXOC4_uc011kpo.1_Frame_Shift_Del_p.S213fs|EXOC4_uc003vri.2_Frame_Shift_Del_p.S314fs|EXOC4_uc003vrj.2_Frame_Shift_Del_p.S314fs	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	314					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				TGAAGAGGTCTACAACCCAGG	0.478													77	22	---	---	---	---					
