Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLHL17	339451	broad.mit.edu	37	1	898791	898791	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:898791C>T	uc001aca.1	+	8	1369	c.1262C>T	c.(1261-1263)TCC>TTC	p.S421F	KLHL17_uc001acc.1_RNA|KLHL17_uc010nyb.1_3'UTR	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	421	Interaction with F-actin (By similarity).|Kelch 2.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCGGAGGTGTCCATGGGCACA	0.622													27	16					0	0	0.000878237	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887453	12887453	+	Missense_Mutation	SNP	C	T	T	rs2486714	by1000genomes	TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:12887453C>T	uc001auk.2	-	3	600	c.404G>A	c.(403-405)AGA>AAA	p.R135K		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	135											0						TAGTAAATCTCTCCTCTGCTT	0.463													6	82					0	0	0.000442599	0	0
CROCCL1	84809	broad.mit.edu	37	1	16946407	16946407	+	RNA	SNP	T	G	G	rs10796418	by1000genomes	TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:16946407T>G	uc010ocf.1	-	3		c.491A>C			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						AGCAATCTCCTCACTCAGCTG	0.672													3	17					0	0	0.000602214	0	0
IL23R	149233	broad.mit.edu	37	1	67721573	67721573	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:67721573C>T	uc001ddo.2	+	10	1287	c.1202C>T	c.(1201-1203)CCT>CTT	p.P401L	IL23R_uc009waz.2_Missense_Mutation_p.P198L|IL23R_uc001ddp.2_RNA|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_5'UTR|IL23R_uc010opk.1_Intron|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_Missense_Mutation_p.P147L|IL23R_uc010opn.1_Missense_Mutation_p.P246L|IL23R_uc001ddr.2_RNA|IL23R_uc010opo.1_Missense_Mutation_p.P260L|IL23R_uc010opp.1_RNA|IL23R_uc010opq.1_Missense_Mutation_p.P230L|IL23R_uc010opr.1_RNA|IL23R_uc010ops.1_Missense_Mutation_p.P198L|IL23R_uc010opt.1_Missense_Mutation_p.P42L|IL23R_uc010opu.1_Missense_Mutation_p.P97L|IL23R_uc010opv.1_Missense_Mutation_p.P159L|IL23R_uc010opw.1_Missense_Mutation_p.P36L|IL23R_uc010opx.1_Missense_Mutation_p.P42L|IL23R_uc010opy.1_Missense_Mutation_p.P168L|IL23R_uc010opz.1_Missense_Mutation_p.P42L|IL23R_uc010oqa.1_Missense_Mutation_p.P42L|IL23R_uc010oqb.1_Missense_Mutation_p.P230L|IL23R_uc010oqc.1_Missense_Mutation_p.P117L|IL23R_uc010oqd.1_Missense_Mutation_p.P36L|IL23R_uc010oqe.1_5'UTR|IL23R_uc010oqf.1_5'UTR|IL23R_uc010oqg.1_5'UTR|IL23R_uc010oqh.1_Missense_Mutation_p.P42L|IL23R_uc001dds.2_Missense_Mutation_p.P146L|IL23R_uc001ddt.2_5'UTR	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	401	Cytoplasmic (Potential).				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						GAAGATATTCCTAATATGAAA	0.333													28	25					0	0	0.00127121	0	0
FCRL5	83416	broad.mit.edu	37	1	157516848	157516848	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:157516848T>G	uc001fqu.2	-	3	350	c.192A>C	c.(190-192)AAA>AAC	p.K64N	FCRL5_uc009wsm.2_Missense_Mutation_p.K64N|FCRL5_uc010phv.1_Missense_Mutation_p.K64N|FCRL5_uc010phw.1_Intron|FCRL5_uc001fqv.1_Missense_Mutation_p.K64N|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	64	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TTAGTATTTCTTTCCCAAGGT	0.502													5	100					0	0	0.000602214	0	0
COPA	1314	broad.mit.edu	37	1	160260465	160260465	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:160260465G>A	uc009wti.2	-	32	3826	c.3432C>T	c.(3430-3432)ATC>ATT	p.I1144I	COPA_uc001fvv.3_Silent_p.I1153I	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	1144					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGCAGACAGGATTTTTCGGG	0.488													62	175					0	0	0.000781405	0	0
DUSP27	92235	broad.mit.edu	37	1	167095025	167095025	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:167095025G>A	uc001geb.1	+	5	657	c.657G>A	c.(655-657)GGG>GGA	p.G219G		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	219	Tyrosine-protein phosphatase.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						TCATTTCAGGGAAAGTCCTGG	0.453													15	25					0	0	0.00244969	0	0
SELP	6403	broad.mit.edu	37	1	169588454	169588454	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:169588454T>G	uc001ggi.3	-	2	72	c.7A>C	c.(7-9)AAC>CAC	p.N3H	SELP_uc001ggh.2_5'UTR|SELP_uc009wvr.2_Missense_Mutation_p.N3H	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	3					platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	ATTTGGCAGTTGGCCTGAAAC	0.383													6	89					0	0	0.00116845	0	0
FMO1	2326	broad.mit.edu	37	1	171251294	171251294	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:171251294C>T	uc009wvz.2	+	7	1141	c.1005C>T	c.(1003-1005)TTC>TTT	p.F335F	FMO1_uc010pme.1_Silent_p.F272F|FMO1_uc001ghl.2_Silent_p.F335F|FMO1_uc001ghm.2_Silent_p.F335F|FMO1_uc001ghn.2_Silent_p.F335F	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	335					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CATTTGCTTTCCCCTTCCTTG	0.418													39	69					0	0	0.00148497	0	0
SLC9A11	284525	broad.mit.edu	37	1	173526486	173526486	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:173526486G>A	uc001giz.2	-	10	1631	c.1208C>T	c.(1207-1209)CCA>CTA	p.P403L	SLC9A11_uc009wwe.2_5'UTR|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	403					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TACCATTTGTGGTACTTCCAC	0.373													43	130					0	0	0.00195071	0	0
LHX4	89884	broad.mit.edu	37	1	180217561	180217561	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:180217561G>A	uc001goe.1	+	2	441	c.218G>A	c.(217-219)GGG>GAG	p.G73E		NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	73	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TCCAGGGCTGGGAGCGTCTAC	0.587													27	58					0	0	0.000720815	0	0
IL19	29949	broad.mit.edu	37	1	207010336	207010336	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:207010336C>T	uc001hep.2	+	4	1117	c.178C>T	c.(178-180)CTG>TTG	p.L60L	IL19_uc001heo.2_Silent_p.L98L|IL19_uc010prx.1_Silent_p.L60L	NM_013371	NP_037503	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 2 precursor	60					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			TGTCACTATCCTGTCCACATT	0.428													42	79					0	0	0.000781405	0	0
CR2	1380	broad.mit.edu	37	1	207640229	207640229	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:207640229G>A	uc001hfw.2	+	2	511	c.417G>A	c.(415-417)GGG>GGA	p.G139G	CR2_uc001hfv.2_Silent_p.G139G|CR2_uc009xch.2_Silent_p.G139G	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	139	Sushi 2.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						ATATGTGGGGGCCGACACGAC	0.473													23	58					0	0	0.00127121	0	0
COMMD3	23412	broad.mit.edu	37	10	22608919	22608919	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr10:22608919C>T	uc001irf.2	+	8	628	c.580C>T	c.(580-582)CAG>TAG	p.Q194*	COMMD3_uc001irg.2_RNA|BMI1_uc009xkg.2_Intron|BMI1_uc001irh.2_5'Flank	NM_012071	NP_036203	Q9UBI1	COMD3_HUMAN	COMM domain containing 3	194							protein binding				0						AAGAGCAACTCAGTTGTAACT	0.463													48	42					0	0	0.000781405	0	0
Unknown	0	broad.mit.edu	37	10	30998233	30998233	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr10:30998233G>A	uc010qdx.1	+	8	1321	c.779G>A	c.(778-780)GGA>GAA	p.G260E						SubName: Full=cDNA FLJ59642, highly similar to Supervillin;																		AAAGATCCCGGAAGTTTTAAC	0.468													18	13					0	0	0.000958276	0	0
OGDHL	55753	broad.mit.edu	37	10	50966519	50966519	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr10:50966519G>C	uc001jie.2	-	2	262	c.120C>G	c.(118-120)TTC>TTG	p.F40L	OGDHL_uc009xog.2_Missense_Mutation_p.F67L|OGDHL_uc010qgt.1_Missense_Mutation_p.F40L|OGDHL_uc010qgu.1_Intron|OGDHL_uc009xoh.2_Intron	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	40					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						TGCTGCTTGGGAAGGTGGCCG	0.637													39	25					0	0	0.00128727	0	0
GBF1	8729	broad.mit.edu	37	10	104140011	104140011	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr10:104140011C>T	uc001kux.1	+	37	5121	c.4881C>T	c.(4879-4881)TTC>TTT	p.F1627F	GBF1_uc001kuy.1_Silent_p.F1623F|GBF1_uc001kuz.1_Silent_p.F1624F	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1627					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CATAGGTCTTCCTGCAGCACC	0.587													66	47					0	0	0.000781405	0	0
B4GALNT4	338707	broad.mit.edu	37	11	376073	376074	+	Splice_Site	DNP	GG	AA	AA			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:376073_376074GG>AA	uc001lpb.2	+	12	1105	c.1096_splice	c.e12-1	p.V366_splice		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta							Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCACCCCCCAGGTGTACCTGTC	0.668													6	20					0	0	6.4e-05	0	0
OR51M1	390059	broad.mit.edu	37	11	5410796	5410796	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:5410796C>T	uc010qzc.1	+	1	168	c.168C>T	c.(166-168)TTC>TTT	p.F56F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	56						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAATTGTTTCATTCTGATCA	0.453													18	119					0	0	0.000566183	0	0
MICAL2	9645	broad.mit.edu	37	11	12231069	12231070	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:12231069_12231070CC>TT	uc001mjz.2	+	6	903_904	c.615_616CC>TT	c.(613-618)CTCCCT>CTTTCT	p.P206S	MICAL2_uc010rch.1_Missense_Mutation_p.P206S|MICAL2_uc001mka.2_Missense_Mutation_p.P206S|MICAL2_uc010rci.1_Missense_Mutation_p.P206S|MICAL2_uc001mkb.2_Missense_Mutation_p.P206S|MICAL2_uc001mkc.2_Missense_Mutation_p.P206S|MICAL2_uc001mkd.2_Missense_Mutation_p.P35S	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	206						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		CAGAATTTCTCCCTACAGACCA	0.52													57	80					0	0	6.4e-05	0	0
SLC6A5	9152	broad.mit.edu	37	11	20673876	20673876	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:20673876C>T	uc001mqd.2	+	15	2385	c.2112C>T	c.(2110-2112)ACC>ACT	p.T704T	SLC6A5_uc009yic.2_Silent_p.T469T	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	704					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	AGCCCATGACCTATGGCTCTT	0.468													55	65					0	0	0.000781405	0	0
OR5L1	219437	broad.mit.edu	37	11	55579441	55579441	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:55579441C>T	uc001nhw.1	+	1	499	c.499C>T	c.(499-501)CCC>TCC	p.P167S		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TCTTAGGATCCCCTTCTATAG	0.448													21	145					0	0	0.00229938	0	0
OR5R1	219479	broad.mit.edu	37	11	56185523	56185523	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:56185523G>A	uc010rji.1	-	1	186	c.186C>T	c.(184-186)TTC>TTT	p.F62F		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GGTGGCTGAGGAAATAGTACA	0.428													10	38					0	0	0.000978159	0	0
SLC43A1	8501	broad.mit.edu	37	11	57268284	57268284	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:57268284C>T	uc001nkk.2	-	5	551	c.433G>A	c.(433-435)GGT>AGT	p.G145S	SLC43A1_uc001nkl.2_Missense_Mutation_p.G145S	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	145	Helical; (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						CAGATGCCACCAAAGCCATTC	0.592													14	20					0	0	0.00244969	0	0
SERPING1	710	broad.mit.edu	37	11	57373518	57373518	+	Missense_Mutation	SNP	C	T	T	rs145436911		TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:57373518C>T	uc001nkp.1	+	5	912	c.721C>T	c.(721-723)CGG>TGG	p.R241W	SERPING1_uc001nkq.1_Missense_Mutation_p.R241W|SERPING1_uc010rju.1_Missense_Mutation_p.R189W|SERPING1_uc010rjv.1_Missense_Mutation_p.R246W|SERPING1_uc001nkr.1_Missense_Mutation_p.R241W|SERPING1_uc009ymi.1_Missense_Mutation_p.R241W|SERPING1_uc009ymj.1_Missense_Mutation_p.R241W|SERPING1_uc001nks.1_5'UTR	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	241					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						GAATGCCTCTCGGACCCTGTA	0.527									Hereditary_Angioedema				20	100					0	0	0.000958276	0	0
TMEM216	51259	broad.mit.edu	37	11	61161357	61161357	+	Silent	SNP	T	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:61161357T>G	uc010rlj.1	+	3	410	c.117T>G	c.(115-117)GGT>GGG	p.G39G	TMEM216_uc001nrn.1_5'UTR	NM_016499	NP_057583	Q9P0N5	TM216_HUMAN	transmembrane protein 216	39						integral to membrane					0						TATTGGCAGGTGTCCTGCTAC	0.438													17	38					0	0	0.000878237	0	0
C11orf9	745	broad.mit.edu	37	11	61543557	61543557	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:61543557C>T	uc001nsc.1	+	9	1437	c.1341C>T	c.(1339-1341)ATC>ATT	p.I447I	C11orf9_uc001nse.1_Silent_p.I438I|C11orf9_uc010rll.1_5'Flank	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	447	NDT80.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CCATTAACATCGAGCAGTCCC	0.622													12	29					0	0	0.00185496	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64138132	64138132	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:64138132C>T	uc001oae.2	+	16	2138	c.2055C>T	c.(2053-2055)CTC>CTT	p.L685L	RPS6KA4_uc001oad.2_Silent_p.L679L|RPS6KA4_uc010rnl.1_Silent_p.L622L|RPS6KA4_uc001oaf.2_Silent_p.L678L|RPS6KA4_uc009ypp.2_Silent_p.L437L	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	685					axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						CGCCCCCGCTCCGGACGCCCG	0.711													8	8					0	0	0.000157383	0	0
BBS1	582	broad.mit.edu	37	11	66287153	66287153	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:66287153G>A	uc001oij.1	+	8	669	c.657G>A	c.(655-657)CTG>CTA	p.L219L	BBS1_uc001oii.1_Silent_p.L256L|BBS1_uc010rpf.1_RNA|BBS1_uc010rpg.1_Intron|BBS1_uc001oik.1_Silent_p.L143L|BBS1_uc001oil.1_Silent_p.L219L	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	219					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						TGTCTTGCCTGGTGCTGGGCA	0.597									Bardet-Biedl_syndrome				14	56					0	0	0.000422831	0	0
LRP5	4041	broad.mit.edu	37	11	68115510	68115510	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:68115510G>A	uc001ont.2	+	2	362	c.287G>A	c.(286-288)GGG>GAG	p.G96E	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	96	Beta-propeller 1.|LDL-receptor class B 1.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						AACCAGACGGGGGCCGCCGTG	0.637													24	105					0	0	0.000586117	0	0
MYO7A	4647	broad.mit.edu	37	11	76910721	76910721	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:76910721C>T	uc001oyb.2	+	35	4982	c.4710C>T	c.(4708-4710)TTC>TTT	p.F1570F	MYO7A_uc010rsm.1_Silent_p.F1521F|MYO7A_uc001oyc.2_Silent_p.F1532F|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Silent_p.F743F	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1570	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCCCCAGCTTCACGCTGGCCA	0.637													11	19					0	0	0.00136819	0	0
AQP11	282679	broad.mit.edu	37	11	77301464	77301464	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:77301464C>T	uc001oyj.2	+	1	785	c.427C>T	c.(427-429)CTG>TTG	p.L143L	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	143						cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			GAGCTTGGGTCTGACCCAGTA	0.597													23	38					0	0	0.00278032	0	0
MMP27	64066	broad.mit.edu	37	11	102567432	102567432	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:102567432C>T	uc001phd.1	-	5	777	c.754G>A	c.(754-756)GAT>AAT	p.D252N		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	252					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		CCATTGATATCATCCTGAGAA	0.388													9	27					0	0	0.000442599	0	0
RBM7	10179	broad.mit.edu	37	11	114272447	114272447	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr11:114272447C>T	uc001pov.2	+	2	134	c.124C>T	c.(124-126)CCA>TCA	p.P42S	C11orf71_uc001pot.1_5'Flank|C11orf71_uc001pou.3_5'Flank|RBM7_uc001pow.2_Missense_Mutation_p.P42S|RBM7_uc001pox.2_5'UTR	NM_016090	NP_057174	Q9Y580	RBM7_HUMAN	RNA binding motif protein 7	42	RRM.				meiosis		nucleotide binding|protein binding|RNA binding			ovary(2)	2		all_cancers(61;5.06e-12)|all_epithelial(67;5.3e-06)|all_hematologic(158;7.68e-05)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.56e-06)|Epithelial(105;4.17e-05)|all cancers(92;0.000348)		GGTGAAAATTCCAAAAGATAA	0.313													7	17					0	0	0.000157383	0	0
PRR4	11272	broad.mit.edu	37	12	10999770	10999770	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:10999770G>A	uc001qyz.3	-	3	336	c.297C>T	c.(295-297)CAC>CAT	p.H99H	PRR4_uc009zhp.2_Silent_p.H112H|PRH1_uc001qzb.3_RNA|PRR4_uc001qza.3_Intron	NM_007244	NP_009175	Q16378	PROL4_HUMAN	proline rich 4 (lacrimal) isoform 2	99					visual perception	extracellular space					0						AGAGTTGACGGTGTCCTCGTC	0.557													73	139					0	0	0.000781405	0	0
ALG10	84920	broad.mit.edu	37	12	34179674	34179674	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:34179674C>T	uc001rlm.2	+	3	1565	c.1246C>T	c.(1246-1248)CGT>TGT	p.R416C		NM_032834	NP_116223	Q5BKT4	AG10A_HUMAN	asparagine-linked glycosylation 10 homolog	416	Extracellular (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			skin(1)	1	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				GCTGGAATTTCGTTACTTCAT	0.348													69	156					0	0	0.000781405	0	0
FAM113B	91523	broad.mit.edu	37	12	47629822	47629822	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:47629822C>T	uc001rpn.2	+	4	1707	c.976C>T	c.(976-978)CAT>TAT	p.H326Y	FAM113B_uc001rpq.2_Missense_Mutation_p.H326Y	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	326	Pro-rich.						hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					tcccATTCTCCATCACCAGGG	0.269													46	94					0	0	0.000781405	0	0
RND1	27289	broad.mit.edu	37	12	49255804	49255804	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:49255804G>A	uc001rsn.2	-	3	409	c.306C>T	c.(304-306)AGC>AGT	p.S102S		NM_014470	NP_055285	Q92730	RND1_HUMAN	GTP-binding protein RHO6 precursor	102					actin filament organization|axon guidance|negative regulation of cell adhesion|neuron remodeling|small GTPase mediated signal transduction	adherens junction|cytoskeleton|cytosol	GTP binding|GTPase activity|receptor binding			ovary(1)	1						TCTTGAGTGCGCTGTCCACTG	0.438													35	86					0	0	0.000953801	0	0
TFCP2	7024	broad.mit.edu	37	12	51492621	51492621	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:51492621A>G	uc001rxw.2	-	13	1816	c.1357T>C	c.(1357-1359)TGC>CGC	p.C453R	TFCP2_uc001rxv.1_Missense_Mutation_p.C453R|TFCP2_uc009zlx.1_Missense_Mutation_p.C402R|TFCP2_uc001rxx.2_Missense_Mutation_p.C375R|TFCP2_uc009zly.1_Missense_Mutation_p.C355R	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	453					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTGATCTGGCAAGGGGAAATG	0.408													21	46					0	0	0.00278032	0	0
KRT1	3848	broad.mit.edu	37	12	53072333	53072333	+	Silent	SNP	G	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:53072333G>T	uc001sau.1	-	2	858	c.799C>A	c.(799-801)CGG>AGG	p.R267R	KRT1_uc001sav.1_Silent_p.R267R	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	267	Coil 1B.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						TACTTGTTCCGGTAATCCTCC	0.438													5	136					0.00198382	0.00991909	0.00198382	1	0
BEST3	144453	broad.mit.edu	37	12	70049472	70049472	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:70049472G>A	uc001svg.2	-	10	1449	c.1222C>T	c.(1222-1224)CCC>TCC	p.P408S	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.P195S|BEST3_uc010stm.1_Missense_Mutation_p.P302S	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	408	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CTTCTTCTGGGGCTGGAGGGG	0.557													54	109					0	0	0.000781405	0	0
PTPRB	5787	broad.mit.edu	37	12	70981045	70981045	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:70981045G>A	uc001swb.3	-	7	1429	c.1399C>T	c.(1399-1401)CCC>TCC	p.P467S	PTPRB_uc010sto.1_Missense_Mutation_p.P467S|PTPRB_uc010stp.1_Missense_Mutation_p.P377S|PTPRB_uc001swc.3_Missense_Mutation_p.P685S|PTPRB_uc001swa.3_Missense_Mutation_p.P685S|PTPRB_uc001swd.3_Missense_Mutation_p.P684S|PTPRB_uc009zrr.1_Missense_Mutation_p.P564S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	467	Fibronectin type-III 6.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ACAGCCAGGGGGACTGAGGAA	0.458													20	28					0	0	0.00229938	0	0
RASSF9	9182	broad.mit.edu	37	12	86198791	86198791	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:86198791G>A	uc001taf.1	-	2	1336	c.997C>T	c.(997-999)CAC>TAC	p.H333Y		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	333					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						AAATGAGAGTGAATTTTCAAA	0.393													93	225					0	0	0.000781405	0	0
CDK17	5128	broad.mit.edu	37	12	96691070	96691070	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:96691070A>G	uc001tep.1	-	9	1340	c.851T>C	c.(850-852)ATC>ACC	p.I284T	CDK17_uc009ztk.2_Missense_Mutation_p.I284T|CDK17_uc010svb.1_Missense_Mutation_p.I231T	NM_002595	NP_002586	Q00537	CDK17_HUMAN	PCTAIRE protein kinase 2	284	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			ovary(3)|lung(2)|kidney(1)|central_nervous_system(1)	7						CATACTCATGATGTTTCCACA	0.363													6	24					0	0	0.00198382	0	0
IGF1	3479	broad.mit.edu	37	12	102813412	102813412	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:102813412C>T	uc001tjp.3	-	3	496	c.277G>A	c.(277-279)GAT>AAT	p.D93N	IGF1_uc001tjn.2_Missense_Mutation_p.D77N|IGF1_uc001tjm.2_Missense_Mutation_p.D93N|IGF1_uc001tjo.2_Missense_Mutation_p.D93N	NM_001111285	NP_001104755	P05019	IGF1_HUMAN	insulin-like growth factor 1 isoform 3	93	A.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|pancreas(1)	2						CAGCACTCATCCACGATGCCT	0.587													10	46					0	0	0.000978159	0	0
C12orf42	374470	broad.mit.edu	37	12	103699889	103699889	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:103699889G>A	uc001tjt.2	-	5	582	c.494C>T	c.(493-495)TCA>TTA	p.S165L	C12orf42_uc001tjs.2_Intron|C12orf42_uc009zuf.1_Missense_Mutation_p.S165L|C12orf42_uc001tju.2_Missense_Mutation_p.S70L	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	165										ovary(1)|central_nervous_system(1)	2						TTCCAAAAATGAACTGTTCCA	0.488													36	56					0	0	0.00283554	0	0
ALDH1L2	160428	broad.mit.edu	37	12	105420355	105420355	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:105420355C>A	uc001tlc.2	-	22	2811	c.2684G>T	c.(2683-2685)GGA>GTA	p.G895V	ALDH1L2_uc009zuo.2_Missense_Mutation_p.G350V|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	895	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						TTGTTTAACTCCGCCAAATGG	0.393													30	71					1.7881e-09	9.0914e-09	0.001512	1	0
ANAPC7	51434	broad.mit.edu	37	12	110812041	110812041	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:110812041T>A	uc001tqo.2	-	11	1709	c.1708A>T	c.(1708-1710)ATG>TTG	p.M570L		NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	anaphase-promoting complex subunit 7 isoform a	570					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0						CTCCCTTCCATGTCGTCCACA	0.612													5	115					0	0	0.00198382	0	0
B3GNT4	79369	broad.mit.edu	37	12	122691861	122691861	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:122691861G>A	uc001ubx.2	+	3	1281	c.1063G>A	c.(1063-1065)GAG>AAG	p.E355K	B3GNT4_uc001uby.2_Missense_Mutation_p.E330K	NM_030765	NP_110392	Q9C0J1	B3GN4_HUMAN	UDP-GlcNAc:betaGal	355	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000297)|Epithelial(86;0.000497)|BRCA - Breast invasive adenocarcinoma(302;0.222)		CAGCCCCCTCGAGATGTGGAC	0.627													15	39					0	0	0.000566183	0	0
FZD10	11211	broad.mit.edu	37	12	130649206	130649206	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:130649206C>T	uc001uii.2	+	1	2175	c.1719C>T	c.(1717-1719)ATC>ATT	p.I573I	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	573	Cytoplasmic (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		AATATGAGATCCCTGCCCAGT	0.547													17	19					0	0	0.000958276	0	0
RNF17	56163	broad.mit.edu	37	13	25448326	25448326	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr13:25448326C>T	uc001upr.2	+	33	4563	c.4522C>T	c.(4522-4524)CCT>TCT	p.P1508S	RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.P1504S|RNF17_uc001ups.2_Missense_Mutation_p.P1447S|RNF17_uc010aac.2_Missense_Mutation_p.P700S|RNF17_uc010aad.2_Missense_Mutation_p.P518S	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1508	Tudor 4.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AGAATTTAATCCTTTATCTAT	0.328													29	45					0	0	0.00127121	0	0
NUPL1	9818	broad.mit.edu	37	13	25889500	25889500	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr13:25889500G>A	uc001uqi.2	+	6	826	c.580G>A	c.(580-582)GGA>AGA	p.G194R	NUPL1_uc001uqg.1_Missense_Mutation_p.G194R|NUPL1_uc001uqj.2_Missense_Mutation_p.G182R	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	194	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		TATAGGACTTGGACAGAATGC	0.378													94	259					0	0	0.000781405	0	0
ATP8A2	51761	broad.mit.edu	37	13	26154053	26154053	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr13:26154053C>T	uc001uqk.2	+	22	2117	c.1975C>T	c.(1975-1977)CGG>TGG	p.R659W	ATP8A2_uc010tdi.1_Missense_Mutation_p.R619W|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.R169W	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	619	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CAGAGCTCAACGGTTGGAAGA	0.443													15	39					0	0	0.000308642	0	0
BRCA2	675	broad.mit.edu	37	13	32913284	32913284	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr13:32913284C>T	uc001uub.1	+	11	5019	c.4792C>T	c.(4792-4794)CTC>TTC	p.L1598F		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1598					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GCAGAATTCTCTCAATAATGA	0.368			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			33	79					0	0	0.00283554	0	0
TRPC4	7223	broad.mit.edu	37	13	38211377	38211377	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr13:38211377G>A	uc001uws.2	-	11	2832	c.2597C>T	c.(2596-2598)TCT>TTT	p.S866F	TRPC4_uc010abv.2_Missense_Mutation_p.S446F|TRPC4_uc001uwt.2_Intron|TRPC4_uc010tey.1_Intron|TRPC4_uc010abw.2_Missense_Mutation_p.S693F|TRPC4_uc010abx.2_Missense_Mutation_p.S871F|TRPC4_uc010aby.2_Intron	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	866	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTCTGAAACAGAGAAGATTTG	0.408													20	53					0	0	0.00188189	0	0
NEK5	341676	broad.mit.edu	37	13	52646132	52646132	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr13:52646132C>T	uc001vge.2	-	21	2012	c.1872G>A	c.(1870-1872)GAG>GAA	p.E624E		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	624							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		AATCTCCATGCTCCTTTACAC	0.358													16	26					0	0	0.000308642	0	0
GPC5	2262	broad.mit.edu	37	13	92345703	92345703	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr13:92345703G>A	uc010tif.1	+	3	954	c.588G>A	c.(586-588)ATG>ATA	p.M196I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	196						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GCATCCGGATGGCTCGCCGGG	0.498													13	72					0	0	0.00136819	0	0
F7	2155	broad.mit.edu	37	13	113760179	113760179	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr13:113760179C>T	uc001vsv.2	+	1	75	c.24C>T	c.(22-24)CTC>CTT	p.L8L	F7_uc010agp.1_Silent_p.L23L|F7_uc001vsw.2_Silent_p.L8L|F7_uc010tjt.1_Silent_p.L23L	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	8					anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	CCCTCAGGCTCCTCTGCCTTC	0.592													7	15					0	0	0.000157383	0	0
MYH6	4624	broad.mit.edu	37	14	23865948	23865948	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr14:23865948G>A	uc001wjv.2	-	19	2314	c.2247C>T	c.(2245-2247)AGC>AGT	p.S749S		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	749	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TGTCCAGAGAGCTGAGCAGCT	0.557													37	38					0	0	0.000953801	0	0
SAV1	60485	broad.mit.edu	37	14	51132299	51132299	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr14:51132299G>A	uc001wyg.1	-	3	294	c.133C>T	c.(133-135)CCA>TCA	p.P45S	SAV1_uc001wyh.1_Missense_Mutation_p.P45S	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	WW45 protein	45					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)	1	all_epithelial(31;0.000611)|Breast(41;0.0333)					GTTCGTCTTGGAATTGTTGGA	0.358													5	35					0	0	0.000602214	0	0
DICER1	23405	broad.mit.edu	37	14	95556876	95556876	+	Silent	SNP	G	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr14:95556876G>T	uc001ydw.2	-	28	5910	c.5728C>A	c.(5728-5730)CGA>AGA	p.R1910R	DICER1_uc010avh.1_Silent_p.R808R|DICER1_uc001ydv.2_Silent_p.R1900R|DICER1_uc001ydx.2_Silent_p.R1910R	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1910	DRBM.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TTGAGGCTTCGGAGGGCTCTT	0.398			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				5	156					8.12818e-05	0.00040981	0.00198382	1	0
WDR20	91833	broad.mit.edu	37	14	102675478	102675478	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr14:102675478C>T	uc001ykz.2	+	3	1020	c.971C>T	c.(970-972)CCT>CTT	p.P324L	WDR20_uc001yky.1_Missense_Mutation_p.P67L|WDR20_uc001yla.2_Missense_Mutation_p.P200L|WDR20_uc001ylb.2_Missense_Mutation_p.P263L|WDR20_uc010txu.1_Missense_Mutation_p.P355L|WDR20_uc001ylc.2_Intron|WDR20_uc001yld.2_Missense_Mutation_p.P324L|WDR20_uc001yle.2_Missense_Mutation_p.P263L|WDR20_uc001ylf.2_Missense_Mutation_p.P336L	NM_144574	NP_653175	Q8TBZ3	WDR20_HUMAN	WD repeat domain 20 isoform 2	324											0						GAAGGTGACCCTATGGAGTTT	0.493													22	22					0	0	0.00278032	0	0
RASGRP1	10125	broad.mit.edu	37	15	38852056	38852056	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr15:38852056C>T	uc001zke.3	-	2	364	c.186G>A	c.(184-186)CTG>CTA	p.L62L	RASGRP1_uc001zkd.3_Silent_p.L62L	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	62	Ras exchanger motif region; required for transforming activity (By similarity).|N-terminal Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TGAGATCGTCCAGGCTGGCTC	0.498													12	49					0	0	0.00185496	0	0
DMXL2	23312	broad.mit.edu	37	15	51830432	51830432	+	Silent	SNP	A	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr15:51830432A>G	uc002abf.2	-	10	1548	c.1323T>C	c.(1321-1323)GGT>GGC	p.G441G	DMXL2_uc010ufy.1_Silent_p.G441G|DMXL2_uc010bfa.2_Silent_p.G441G	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	441						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TCATATGTAAACCCCGTTCTC	0.358													7	110					0	0	0.000274275	0	0
PRTG	283659	broad.mit.edu	37	15	55919241	55919241	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr15:55919241G>A	uc002adg.2	-	17	2940	c.2892C>T	c.(2890-2892)ATC>ATT	p.I964I		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	964	Helical; (Potential).				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TGAGAACACAGATGAGGATGC	0.408													18	41					0	0	0.00074312	0	0
IQCH	64799	broad.mit.edu	37	15	67713666	67713666	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr15:67713666C>T	uc002aqo.1	+	16	2303	c.2256C>T	c.(2254-2256)GTC>GTT	p.V752V	IQCH_uc002aqq.1_Silent_p.V409V|IQCH_uc002aqp.1_Silent_p.V413V|uc002aqr.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	752										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		CAGACAATGTCACCAACCTCA	0.398													12	45					0	0	0.00136819	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042101	75042102	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr15:75042101_75042102CC>TT	uc002ayr.1	+	2	86_87	c.22_23CC>TT	c.(22-24)CCC>TTC	p.P8F		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	8					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CCAGTCTGTTCCCTTCTCGGCC	0.535													88	214					0	0	6.4e-05	0	0
EFTUD1	79631	broad.mit.edu	37	15	82443893	82443893	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr15:82443893C>T	uc002bgt.1	-	18	3071	c.2902G>A	c.(2902-2904)GCA>ACA	p.A968T	EFTUD1_uc002bgs.1_Missense_Mutation_p.A339T|EFTUD1_uc002bgu.1_Missense_Mutation_p.A917T	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	968					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						TAGCGACATGCTTCTTTCATG	0.483													5	160					0	0	0.00198382	0	0
OR4F6	390648	broad.mit.edu	37	15	102346732	102346732	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr15:102346732C>T	uc010utr.1	+	1	810	c.810C>T	c.(808-810)TTC>TTT	p.F270F		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	270	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TTGATAAATTCCTTGCCATCT	0.383													35	72					0	0	0.0024448	0	0
AXIN1	8312	broad.mit.edu	37	16	354394	354394	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr16:354394G>A	uc002cgp.1	-	5	1341	c.1164C>T	c.(1162-1164)TTC>TTT	p.F388F	AXIN1_uc002cgq.1_Silent_p.F388F	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	388	Interaction with GSK3B (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GCTCCTCCGCGAACTTCTGAG	0.667													11	32					0	0	0.00185496	0	0
TSC2	7249	broad.mit.edu	37	16	2098705	2098705	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr16:2098705C>A	uc002con.2	+	2	195	c.89C>A	c.(88-90)TCT>TAT	p.S30Y	NTHL1_uc002col.1_5'Flank|NTHL1_uc002com.1_5'Flank|TSC2_uc010uvu.1_Missense_Mutation_p.S30Y|TSC2_uc010bsd.2_Missense_Mutation_p.S30Y|TSC2_uc002coo.2_Missense_Mutation_p.S30Y|TSC2_uc010uvv.1_Missense_Mutation_p.S30Y|TSC2_uc010uvw.1_Intron|TSC2_uc002cop.2_Translation_Start_Site	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	30	Required for interaction with TSC1.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				AATCCCAGGTCTGCAGAGGGT	0.498			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				24	68					7.87624e-14	4.03867e-13	0.00278032	1	0
SRRM2	23524	broad.mit.edu	37	16	2816697	2816698	+	Missense_Mutation	DNP	CC	TT	TT	rs144781002		TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr16:2816697_2816698CC>TT	uc002crk.2	+	11	6717_6718	c.6168_6169CC>TT	c.(6166-6171)TCCCGT>TCTTGT	p.R2057C	SRRM2_uc002crj.1_Missense_Mutation_p.R1961C|SRRM2_uc002crl.1_Missense_Mutation_p.R2057C|SRRM2_uc010bsu.1_Missense_Mutation_p.R1961C	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2057	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCTCCAGATCCCGTACTCCACG	0.564													21	41					0	0	6.4e-05	0	0
TXNDC11	51061	broad.mit.edu	37	16	11785738	11785738	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr16:11785738G>A	uc010buu.1	-	9	1451	c.1389C>T	c.(1387-1389)TCC>TCT	p.S463S	TXNDC11_uc002dbg.1_Silent_p.S436S	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	463					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						TGTGGGTCCTGGAGAAGGAGT	0.622													15	54					0	0	0.000308642	0	0
Unknown	0	broad.mit.edu	37	16	21854780	21854780	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr16:21854780G>A	uc002djr.3	-	6	654	c.472C>T	c.(472-474)CGT>TGT	p.R158C	uc002djs.3_RNA|uc002djq.3_Missense_Mutation_p.R139C|uc010vbn.1_Missense_Mutation_p.R158C	NM_130464	NP_569731			nuclear pore complex interacting protein-like 3																		TTCCTCTTACGGATTTTAGCT	0.388													23	145					0	0	0.00178596	0	0
LONP2	83752	broad.mit.edu	37	16	48311272	48311272	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr16:48311272C>G	uc002efi.1	+	8	1354	c.1265C>G	c.(1264-1266)CCT>CGT	p.P422R	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.P378R	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	422					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						GGCAGCATGCCTGGTCGCATC	0.483													24	78					0	0	0.000720815	0	0
TAF1C	9013	broad.mit.edu	37	16	84212771	84212771	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr16:84212771G>A	uc002fhn.2	-	14	2614	c.2386C>T	c.(2386-2388)CAG>TAG	p.Q796*	TAF1C_uc002fhm.2_Nonsense_Mutation_p.Q702*|TAF1C_uc010vnx.1_Nonsense_Mutation_p.Q770*|TAF1C_uc010vny.1_Nonsense_Mutation_p.Q387*|TAF1C_uc010vnz.1_Nonsense_Mutation_p.Q464*|TAF1C_uc002fho.2_Nonsense_Mutation_p.Q319*|TAF1C_uc010voa.1_Nonsense_Mutation_p.Q464*|TAF1C_uc002fhp.1_RNA	NM_005679	NP_005670	Q15572	TAF1C_HUMAN	TBP-associated factor 1C isoform 1	796					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			ovary(1)	1						GTCAACTCCTGGGAGGGCGGG	0.662													9	13					0	0	0.000442599	0	0
GALNS	2588	broad.mit.edu	37	16	88904144	88904144	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr16:88904144G>A	uc002fly.3	-	5	541	c.452C>T	c.(451-453)CCC>CTC	p.P151L	GALNS_uc010cid.2_Missense_Mutation_p.P157L|GALNS_uc002flz.3_Intron	NM_000512	NP_000503	P34059	GALNS_HUMAN	galactosamine (N-acetyl)-6-sulfate sulfatase	151			P -> L (in MPS4A; severe form).|P -> S (in MPS4A; severe form).			lysosome	metal ion binding|N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity			large_intestine(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	GTGCTTCAGGGGGTGGAACTG	0.572													29	53					0	0	0.00283554	0	0
TUBB3	10381	broad.mit.edu	37	16	90001226	90001226	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr16:90001226G>T	uc002fph.1	+	4	432	c.367G>T	c.(367-369)GAG>TAG	p.E123*	TUBB3_uc002fpf.2_Nonsense_Mutation_p.E470*|TUBB3_uc010ciz.1_Nonsense_Mutation_p.E51*|TUBB3_uc002fpg.1_5'UTR|TUBB3_uc002fpi.1_Nonsense_Mutation_p.E51*|TUBB3_uc002fpj.1_Nonsense_Mutation_p.E51*|TUBB3_uc010cjb.1_5'UTR|TUBB3_uc002fpk.1_5'UTR	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	123					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGTGCGGAAGGAGTGTGAAAA	0.652													18	52					2.4624e-09	1.24672e-08	0.00121646	1	0
ZZEF1	23140	broad.mit.edu	37	17	4020382	4020382	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr17:4020382T>C	uc002fxe.2	-	3	642	c.578A>G	c.(577-579)AAT>AGT	p.N193S	ZZEF1_uc002fxk.1_Missense_Mutation_p.N193S	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	193							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGAGAGCCGATTGCGGTGCAG	0.507													51	117					0	0	0.000781405	0	0
MYH8	4626	broad.mit.edu	37	17	10317561	10317561	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr17:10317561C>T	uc002gmm.2	-	11	1051	c.956G>A	c.(955-957)GGG>GAG	p.G319E	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	319	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TGTGATCTCCCCCTGACTGAC	0.393									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				101	239					0	0	0.000781405	0	0
PIGL	9487	broad.mit.edu	37	17	16120579	16120579	+	Silent	SNP	C	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr17:16120579C>G	uc002gpv.2	+	1	71	c.39C>G	c.(37-39)GTC>GTG	p.V13V	NCOR1_uc002gpo.2_5'Flank|PIGL_uc010vwd.1_Silent_p.V13V|NCOR1_uc002gps.1_5'Flank|NCOR1_uc010coz.1_5'Flank|NCOR1_uc010cpb.1_5'Flank|NCOR1_uc010cpa.1_5'Flank|NCOR1_uc002gpu.2_5'Flank	NM_004278	NP_004269	Q9Y2B2	PIGL_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	13	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminylphosphatidylinositol deacetylase activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0934)		CGTTGGCGGTCTTGGCATGGG	0.612													17	59					0	0	0.00121646	0	0
TMEM97	27346	broad.mit.edu	37	17	26652620	26652620	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr17:26652620A>G	uc002hat.2	+	2	363	c.218A>G	c.(217-219)GAG>GGG	p.E73G		NM_014573	NP_055388	Q5BJF2	TMM97_HUMAN	transmembrane protein 97	73	Helical; (Potential).				cholesterol homeostasis|regulation of cell growth	integral to membrane|lysosome|nuclear membrane|plasma membrane|rough endoplasmic reticulum	protein binding				0	all_lung(13;0.000238)|Lung NSC(42;0.000789)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CTGTTTTGCGAGCTTGTGTTT	0.453													43	81					0	0	0.00222228	0	0
UNC45B	146862	broad.mit.edu	37	17	33501269	33501269	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr17:33501269G>A	uc002hja.2	+	14	1942	c.1845G>A	c.(1843-1845)AAG>AAA	p.K615K	UNC45B_uc002hjb.2_Silent_p.K613K|UNC45B_uc002hjc.2_Silent_p.K613K|UNC45B_uc010cto.2_Silent_p.K534K	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	615					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				AGGACAAGAAGGACTTTATAG	0.507													60	137					0	0	0.000781405	0	0
SLFN12L	342615	broad.mit.edu	37	17	33806727	33806727	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr17:33806727C>T	uc002hjn.2	-	3	1468	c.589G>A	c.(589-591)GAA>AAA	p.E197K		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						CCAGTTTTTTCCATGTCTTTG	0.453													6	16					0	0	0.000274275	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183134	39183134	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr17:39183134C>T	uc002hvu.2	-	1	321	c.274G>A	c.(274-276)GGA>AGA	p.G92R		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	92	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			CAGCCAGTTCCGCAGGAGCTG	0.627													4	57					0	0	0.00024832	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47218632	47218632	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr17:47218632A>G	uc002ion.2	+	2	277	c.218A>G	c.(217-219)AAG>AGG	p.K73R	B4GALNT2_uc010wlt.1_5'UTR|B4GALNT2_uc010wlu.1_Missense_Mutation_p.K13R	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	73	Helical; Signal-anchor for type II membrane protein; (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			TGGCTCCTCAAGATATTGGTC	0.393													80	184					0	0	0.000781405	0	0
ENGASE	64772	broad.mit.edu	37	17	77081744	77081744	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr17:77081744C>T	uc002jwv.2	+	13	1751	c.1743C>T	c.(1741-1743)CTC>CTT	p.L581L	ENGASE_uc002jww.2_Silent_p.L286L	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	581						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						TGCTAGACCTCCTCGTTTGCT	0.657													15	47					0	0	0.00152264	0	0
C17orf70	80233	broad.mit.edu	37	17	79517916	79517916	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr17:79517916G>A	uc002kaq.2	-	3	659	c.604C>T	c.(604-606)CCA>TCA	p.P202S	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Missense_Mutation_p.P51S	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	202					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GAGCCTGATGGTGACACAGAG	0.672													9	20					0	0	0.000442599	0	0
C18orf19	125228	broad.mit.edu	37	18	13681927	13681927	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr18:13681927G>A	uc010dlh.2	-	3	582	c.150C>T	c.(148-150)GGC>GGT	p.G50G	C18orf19_uc010dlg.2_Silent_p.G50G|C18orf19_uc010dli.2_Silent_p.G50G|C18orf19_uc002ksj.3_Silent_p.G50G|C18orf19_uc010dlj.2_Intron	NM_001098801	NP_001092271	Q96ND0	CR019_HUMAN	hypothetical protein LOC125228	50						integral to membrane				breast(2)	2						GTTTTTGAGGGCCTTGTACCA	0.453													23	124					0	0	0.00188189	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995558	19995558	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr18:19995558G>A	uc002ktv.1	-	1	2321	c.2217C>T	c.(2215-2217)TTC>TTT	p.F739F		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	739	Pro-rich.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					GGGCTGGGGGGAAAAATGCAG	0.498													11	13					0	0	0.000978159	0	0
PIAS2	9063	broad.mit.edu	37	18	44408073	44408073	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr18:44408073G>A	uc002lck.2	-	11	1515	c.1357C>T	c.(1357-1359)CCT>TCT	p.P453S	PIAS2_uc010dnp.2_Missense_Mutation_p.P151S|PIAS2_uc002lcl.2_Missense_Mutation_p.P453S|PIAS2_uc010xda.1_Missense_Mutation_p.P151S|PIAS2_uc002lcm.2_Missense_Mutation_p.P453S	NM_004671	NP_004662	O75928	PIAS2_HUMAN	protein inhibitor of activated STAT X isoform	453					androgen receptor signaling pathway|negative regulation of androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|PML body	androgen receptor binding|DNA binding|protein binding|SUMO ligase activity|transcription coactivator activity|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						ACTGAACAAGGCTTACTGAGG	0.383													12	48					0	0	0.000308642	0	0
MYO5B	4645	broad.mit.edu	37	18	47511176	47511176	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr18:47511176G>A	uc002leb.2	-	8	1146	c.858C>T	c.(856-858)TTC>TTT	p.F286F	MYO5B_uc002lec.1_Silent_p.F285F	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	286	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GTGATGTATAGAAAAAGTCCT	0.512													7	58					0	0	0.000157383	0	0
ALPK2	115701	broad.mit.edu	37	18	56204595	56204595	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr18:56204595C>T	uc002lhj.3	-	5	3038	c.2824G>A	c.(2824-2826)GAA>AAA	p.E942K	ALPK2_uc002lhk.1_Missense_Mutation_p.E273K	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	942			E -> K (in an ovarian undifferentiated carcinoma sample; somatic mutation).				ATP binding|protein serine/threonine kinase activity	p.E308K(1)		ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						AGCTGTGTTTCATCAAGCCCT	0.527													22	33					0	0	0.00188189	0	0
SERPINB4	6318	broad.mit.edu	37	18	61309074	61309074	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr18:61309074C>T	uc002ljf.2	-	4	357	c.271G>A	c.(271-273)GAA>AAA	p.E91K	SERPINB4_uc002lje.2_Missense_Mutation_p.E91K|SERPINB4_uc002ljg.2_Intron	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	91					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						TTGTTGAATTCAGTCAGAAGC	0.383													19	98					0	0	0.00188189	0	0
CDH7	1005	broad.mit.edu	37	18	63489479	63489479	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr18:63489479C>T	uc002ljz.2	+	5	1113	c.788C>T	c.(787-789)CCT>CTT	p.P263L	CDH7_uc002lka.2_Missense_Mutation_p.P263L|CDH7_uc002lkb.2_Missense_Mutation_p.P263L	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	263	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CCTCGCTTTCCTCGAAGTAAG	0.363													20	21					0	0	0.00188189	0	0
NETO1	81832	broad.mit.edu	37	18	70451055	70451055	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr18:70451055G>A	uc002lkw.2	-	7	1010	c.726C>T	c.(724-726)TCC>TCT	p.S242S	NETO1_uc002lkx.1_Silent_p.S241S|NETO1_uc002lky.1_Silent_p.S242S	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	242	CUB 2.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AATCCTCCACGGAACTGCTTC	0.443													56	77					0	0	0.000781405	0	0
ADNP2	22850	broad.mit.edu	37	18	77895150	77895150	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr18:77895150C>T	uc002lnw.2	+	4	2309	c.1854C>T	c.(1852-1854)GCC>GCT	p.A618A		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	618					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		ACACGCTGGCCCCCGTGTCTG	0.597													13	43					0	0	0.00185496	0	0
C19orf28	126321	broad.mit.edu	37	19	3544870	3544870	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:3544870C>T	uc002lxz.2	-	9	1527	c.1357G>A	c.(1357-1359)GTG>ATG	p.V453M	C19orf28_uc002lxw.2_Missense_Mutation_p.V453M|C19orf28_uc002lxx.2_Missense_Mutation_p.V453M|C19orf28_uc002lxy.2_Missense_Mutation_p.V444M	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	453	Helical; (Potential).				transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCACGCCCACGCCGCCCGTC	0.687											OREG0025153	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	17					0	0	0.000673444	0	0
CLEC4M	10332	broad.mit.edu	37	19	7831649	7831649	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:7831649G>A	uc002mih.2	+	6	941	c.823G>A	c.(823-825)GAA>AAA	p.E275K	CLEC4M_uc010xjv.1_3'UTR|CLEC4M_uc002mhy.2_3'UTR|CLEC4M_uc010xjw.1_Missense_Mutation_p.E231K|CLEC4M_uc010dvt.2_Missense_Mutation_p.E252K|CLEC4M_uc010dvs.2_Missense_Mutation_p.E274K|CLEC4M_uc010xjx.1_Missense_Mutation_p.E247K|CLEC4M_uc002mhz.2_Missense_Mutation_p.E206K|CLEC4M_uc002mic.2_Missense_Mutation_p.E270K|CLEC4M_uc002mia.2_Missense_Mutation_p.E162K	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	298	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						CGCCTGCCAGGAAGTGAGGGC	0.597													24	69					0	0	0.000878237	0	0
MUC16	94025	broad.mit.edu	37	19	9057123	9057123	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:9057123C>T	uc002mkp.2	-	3	30527	c.30323G>A	c.(30322-30324)GGA>GAA	p.G10108E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10110	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACTGGTGGTTCCCACATTGGT	0.478													37	60					0	0	0.000692331	0	0
MUC16	94025	broad.mit.edu	37	19	9077090	9077090	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:9077090G>A	uc002mkp.2	-	3	10560	c.10356C>T	c.(10354-10356)ATC>ATT	p.I3452I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3453	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTGGAGGTGATGTATAATG	0.483													24	52					0	0	0.00278032	0	0
KANK2	25959	broad.mit.edu	37	19	11285168	11285168	+	Silent	SNP	C	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:11285168C>A	uc010dxv.2	-	11	2607	c.2049G>T	c.(2047-2049)GTG>GTT	p.V683V	KANK2_uc002mqm.2_Silent_p.V691V|KANK2_uc002mqo.3_Silent_p.V683V|KANK2_uc002mqp.1_Silent_p.V492V	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	683	ANK 1.										0						GCAGCTGCTGCACCACGGGGA	0.637													4	13					0.00024832	0.00124677	0.00024832	1	0
ZNF490	57474	broad.mit.edu	37	19	12691317	12691317	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:12691317A>C	uc002mtz.2	-	5	1701	c.1572T>G	c.(1570-1572)CAT>CAG	p.H524Q		NM_020714	NP_065765	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	524	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCTGTCTACTATGAGTCCTTT	0.398													50	157					0	0	0.000781405	0	0
CYP4F12	66002	broad.mit.edu	37	19	15784510	15784510	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:15784510G>A	uc002nbl.2	+	2	232	c.171G>A	c.(169-171)CGG>CGA	p.R57R	CYP4F12_uc010xoo.1_Silent_p.R57R|CYP4F12_uc010xop.1_Silent_p.R57R	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					CCCCAAAACGGAACTGGTTTT	0.587													41	91					0	0	0.0025221	0	0
Unknown	0	broad.mit.edu	37	19	15881905	15881905	+	RNA	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:15881905C>T	uc002nbo.2	-	6		c.993G>A			uc010xor.1_Missense_Mutation_p.V158I					Homo sapiens cDNA FLJ60024 complete cds, highly similar to Cytochrome P450 4F12 (EC 1.14.14.1).																		TCCTGGATGACGGCATCTGTG	0.542													24	44					0	0	0.000586117	0	0
NWD1	284434	broad.mit.edu	37	19	16860971	16860971	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:16860971C>T	uc002neu.3	+	6	1940	c.1518C>T	c.(1516-1518)CTC>CTT	p.L506L	NWD1_uc002net.3_Silent_p.L371L|NWD1_uc002nev.3_Silent_p.L300L			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	506	NACHT.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						TGATCCAACTCCTGCTGGCAG	0.642													29	59					0	0	0.00178596	0	0
CILP2	148113	broad.mit.edu	37	19	19656504	19656504	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:19656504C>T	uc002nmv.3	+	8	3235	c.3150C>T	c.(3148-3150)GCC>GCT	p.A1050A	CILP2_uc002nmw.3_Silent_p.A1056A	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1050						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CCATGCTGGCCCCCCTAGACC	0.657													7	18					0	0	0.00198382	0	0
RYR1	6261	broad.mit.edu	37	19	39019618	39019618	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:39019618G>A	uc002oit.2	+	76	11192	c.11062G>A	c.(11062-11064)GAA>AAA	p.E3688K	RYR1_uc002oiu.2_Missense_Mutation_p.E3683K|RYR1_uc002oiv.1_Missense_Mutation_p.E603K|RYR1_uc010xuf.1_Missense_Mutation_p.E608K	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3688					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ggaggaggaggaagaggtgga	0.493													6	16					0	0	0.00116845	0	0
CYP2A13	1553	broad.mit.edu	37	19	41600879	41600879	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:41600879C>T	uc002opt.2	+	8	1186	c.1177C>T	c.(1177-1179)CCT>TCT	p.P393S		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	393					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	TGAAGTGTTCCCTATGCTGGG	0.572													36	79					0	0	0.00111076	0	0
AXL	558	broad.mit.edu	37	19	41754431	41754431	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:41754431G>A	uc010ehj.2	+	13	1740	c.1550G>A	c.(1549-1551)GGC>GAC	p.G517D	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehk.2_Missense_Mutation_p.G508D	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	517	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						AACAGCCTGGGCATCAGTGAA	0.453													24	39					0	0	0.00209593	0	0
LIPE	3991	broad.mit.edu	37	19	42931281	42931281	+	Silent	SNP	T	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:42931281T>G	uc002otr.2	-	1	298	c.21A>C	c.(19-21)TCA>TCC	p.S7S	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	7					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				ACCTAGACACTGACTTAGAAC	0.527													23	50					0	0	0.00278032	0	0
KLC3	147700	broad.mit.edu	37	19	45850770	45850770	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:45850770G>A	uc002pbf.1	+	4	670	c.555G>A	c.(553-555)AGG>AGA	p.R185R	KLC3_uc010ejy.1_Silent_p.R184R|KLC3_uc002pbg.1_Silent_p.R199R	NM_177417	NP_803136	Q6P597	KLC3_HUMAN	kinesin light chain 3	185						cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		AGGAGGAGAGGAAAGGTGGGT	0.657													14	49					0	0	0.00244969	0	0
MYPOP	339344	broad.mit.edu	37	19	46393958	46393958	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:46393958G>A	uc002pdt.2	-	3	1210	c.1123C>T	c.(1123-1125)CCG>TCG	p.P375S		NM_001012643	NP_001012661	Q86VE0	MYPOP_HUMAN	Myb protein P42POP	375	Pro-rich.					nucleus	DNA binding				0						GAGTCGTGCGGAGGGAGCGGG	0.647													10	15					0	0	0.000442599	0	0
KCNC3	3748	broad.mit.edu	37	19	50826917	50826917	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:50826917G>A	uc002pru.1	-	2	1588	c.1293C>T	c.(1291-1293)TTC>TTT	p.F431F	KCNC3_uc002prt.1_Silent_p.F67F	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	431	Helical; Voltage-sensor; Name=Segment S4; (Potential).				cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GCAGCCCCACGAAGTGCCGGG	0.657													21	41					0	0	0.00152264	0	0
ZNF347	84671	broad.mit.edu	37	19	53644084	53644084	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:53644084G>A	uc002qbb.1	-	5	2066	c.1997C>T	c.(1996-1998)TCA>TTA	p.S666L	ZNF347_uc010eql.1_Missense_Mutation_p.S667L|ZNF347_uc002qbc.1_Missense_Mutation_p.S667L	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	666	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TGCAAGGTGTGAATTCTGAGT	0.418													38	88					0	0	0.00195071	0	0
NCR1	9437	broad.mit.edu	37	19	55420643	55420643	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:55420643C>T	uc002qib.2	+	4	433	c.395C>T	c.(394-396)CCC>CTC	p.P132L	NCR1_uc002qic.2_Missense_Mutation_p.P132L|NCR1_uc002qie.2_Missense_Mutation_p.P132L|NCR1_uc002qid.2_Missense_Mutation_p.P37L|NCR1_uc002qif.2_Missense_Mutation_p.P37L|NCR1_uc010esj.2_Missense_Mutation_p.P25L	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	132	Extracellular (Potential).|Ig-like 2.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		CATCCTGGACCCGAAGTGATC	0.512													17	34					0	0	0.000422831	0	0
ZNF582	147948	broad.mit.edu	37	19	56896336	56896336	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr19:56896336G>A	uc002qmz.1	-	5	609	c.450C>T	c.(448-450)CCC>CCT	p.P150P	ZNF582_uc002qmy.2_Silent_p.P181P	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		GGTCAAAAGTGGGCATTTCTT	0.378													44	90					0	0	0.0025221	0	0
MYADML	151325	broad.mit.edu	37	2	33952355	33952355	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:33952355A>G	uc002rpb.2	-	1	930	c.488T>C	c.(487-489)CTG>CCG	p.L163P		NR_003143				RecName: Full=Myeloid-associated differentiation marker-like protein.;												0						CAGCCCCAACAGGAAACTGGG	0.627													17	10					0	0	0.00121646	0	0
SMYD5	10322	broad.mit.edu	37	2	73449886	73449886	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:73449886C>T	uc002siw.2	+	7	675	c.646C>T	c.(646-648)CAA>TAA	p.Q216*	SMYD5_uc010yre.1_Nonsense_Mutation_p.Q100*|SMYD5_uc002six.1_RNA	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	216							metal ion binding				0						AATCCAGGGCCAACTGGAACT	0.577													15	11					0	0	0.000566183	0	0
TTC31	64427	broad.mit.edu	37	2	74718708	74718709	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:74718708_74718709CC>TT	uc002slt.2	+	8	808_809	c.785_786CC>TT	c.(784-786)CCC>CTT	p.P262L	TTC31_uc002sls.2_Missense_Mutation_p.P191L|TTC31_uc010yrv.1_Missense_Mutation_p.P118L|TTC31_uc002slu.2_Missense_Mutation_p.P118L	NM_022492	NP_071937	Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	262							binding				0						AACCAGGAGCCCCAAGGCAGGG	0.589													60	41					0	0	6.4e-05	0	0
RANBP2	5903	broad.mit.edu	37	2	109371692	109371692	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:109371692T>C	uc002tem.3	+	17	2569	c.2443T>C	c.(2443-2445)TGC>CGC	p.C815R		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	815					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						GAAAATGATTTGCCAACAAGT	0.348													8	262					0	0	0.000157383	0	0
GALNT13	114805	broad.mit.edu	37	2	155307048	155307048	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:155307048G>A	uc002tyr.3	+	13	2223	c.1656G>A	c.(1654-1656)ATG>ATA	p.M552I	GALNT13_uc002tyt.3_3'UTR|GALNT13_uc010fod.2_3'UTR|uc002tyu.1_Intron	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	552	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TAAGGAACATGACCTTGGGCA	0.423													11	36					0	0	0.000673444	0	0
SCN7A	6332	broad.mit.edu	37	2	167304175	167304175	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:167304175G>A	uc002udu.1	-	11	1461	c.1334C>T	c.(1333-1335)TCC>TTC	p.S445F	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	445					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TGTGTCTGTGGAAATTGGTGA	0.383													48	62					0	0	0.000781405	0	0
TTN	7273	broad.mit.edu	37	2	179530158	179530158	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:179530158C>T	uc010zfk.1	-	10	975	c.427G>A	c.(427-429)GAA>AAA	p.E143K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTTCATTTCAGGGACAACT	0.368													44	204					0	0	0.000781405	0	0
TTN	7273	broad.mit.edu	37	2	179588785	179588785	+	Silent	SNP	T	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:179588785T>C	uc010zfg.1	-	70	17693	c.17469A>G	c.(17467-17469)GTA>GTG	p.V5823V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.V2484V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6750							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGATCCAGCTACTTTGCATT	0.443													29	27					0	0	0.00106085	0	0
TTN	7273	broad.mit.edu	37	2	179605623	179605623	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:179605623C>T	uc010zfh.1	-	46	12048	c.11824G>A	c.(11824-11826)GAA>AAA	p.E3942K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E3875K|TTN_uc010zfj.1_Missense_Mutation_p.E3750K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTGCAATTCCTGAGCTCCC	0.418													69	66					0	0	0.000781405	0	0
TTN	7273	broad.mit.edu	37	2	179605649	179605649	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:179605649C>T	uc010zfh.1	-	46	12022	c.11798G>A	c.(11797-11799)AGC>AAC	p.S3933N	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.S3866N|TTN_uc010zfj.1_Missense_Mutation_p.S3741N|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGCTGACTGCTCAATTCATT	0.403													20	86					0	0	0.00152264	0	0
TTN	7273	broad.mit.edu	37	2	179647015	179647015	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:179647015C>T	uc010zfg.1	-	20	3528	c.3304G>A	c.(3304-3306)GGA>AGA	p.G1102R	TTN_uc010zfh.1_Missense_Mutation_p.G1056R|TTN_uc010zfi.1_Missense_Mutation_p.G1056R|TTN_uc010zfj.1_Missense_Mutation_p.G1056R|TTN_uc002unb.2_Missense_Mutation_p.G1102R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1102							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTGGCATCCAAACACCACG	0.498													38	50					0	0	0.000953801	0	0
CERKL	375298	broad.mit.edu	37	2	182413290	182413290	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:182413290G>A	uc002unx.2	-	9	1294	c.1193C>T	c.(1192-1194)TCT>TTT	p.S398F	CERKL_uc002uny.2_Missense_Mutation_p.S372F|CERKL_uc010zfm.1_Missense_Mutation_p.S354F|CERKL_uc002unz.2_Missense_Mutation_p.S120F|CERKL_uc002uoa.2_Missense_Mutation_p.S303F|CERKL_uc002uob.2_Missense_Mutation_p.S120F|CERKL_uc002uoc.2_Missense_Mutation_p.S259F|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_Missense_Mutation_p.S167F|CERKL_uc002uoe.2_Missense_Mutation_p.S372F|CERKL_uc002unw.2_5'Flank	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	398					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CACATCATCAGAGCTGTTAAA	0.313													14	20					0	0	0.000422831	0	0
COL3A1	1281	broad.mit.edu	37	2	189864605	189864605	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:189864605G>A	uc002uqj.1	+	32	2384	c.2267G>A	c.(2266-2268)GGG>GAG	p.G756E		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	756	Triple-helical region.		G -> E (in EDS4).		axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGTGTCCCAGGGAAAGATGGC	0.448													4	22					0	0	0.000602214	0	0
DNAH7	56171	broad.mit.edu	37	2	196681592	196681592	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:196681592G>A	uc002utj.3	-	51	9622	c.9521C>T	c.(9520-9522)TCC>TTC	p.S3174F		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3174	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GGCCTTGGAGGAAGATAATAT	0.403													15	84					0	0	0.000308642	0	0
DNAH7	56171	broad.mit.edu	37	2	196822000	196822000	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:196822000C>T	uc002utj.3	-	19	3164	c.3063G>A	c.(3061-3063)ATG>ATA	p.M1021I		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1021	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGACACTTCTCATTATATCTC	0.378													53	50					0	0	0.000781405	0	0
COL4A4	1286	broad.mit.edu	37	2	227919421	227919421	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:227919421G>A	uc010zlt.1	-	31	3403	c.2749C>T	c.(2749-2751)CCC>TCC	p.P917S		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	917	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CTTTCTCCGGGAAAACCTGGG	0.507													23	24					0	0	0.00047179	0	0
AGFG1	3267	broad.mit.edu	37	2	228401685	228401685	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:228401685C>T	uc002vpc.2	+	10	1604	c.1354C>T	c.(1354-1356)CAG>TAG	p.Q452*	AGFG1_uc002vpd.2_Nonsense_Mutation_p.Q476*|AGFG1_uc002vpe.2_Nonsense_Mutation_p.Q452*|AGFG1_uc002vpf.2_Nonsense_Mutation_p.Q412*	NM_004504	NP_004495	P52594	AGFG1_HUMAN	HIV-1 Rev binding protein isoform 2	452					cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4						AAACCCATTTCAGACCAATGC	0.393													16	81					0	0	0.00152264	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910676	230910676	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:230910676T>C	uc002vqd.1	-	4	1529	c.1166A>G	c.(1165-1167)AAC>AGC	p.N389S	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Missense_Mutation_p.N389S|SLC16A14_uc002vqf.2_Missense_Mutation_p.N389S	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	389	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		AAGGGTGAAGTTGGCCAACAG	0.468													16	23					0	0	0.000566183	0	0
UGT1A3	54659	broad.mit.edu	37	2	234637997	234637997	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr2:234637997C>T	uc002vuy.2	+	1	225	c.225C>T	c.(223-225)TTC>TTT	p.F75F	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Silent_p.F75F	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	75					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGAACTTTTTCACCCTGACAA	0.507													26	99					0	0	0.000878237	0	0
SIRPG	55423	broad.mit.edu	37	20	1638337	1638337	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr20:1638337G>A	uc002wfm.1	-	1	89	c.24C>T	c.(22-24)CCC>CCT	p.P8P	SIRPG_uc002wfn.1_Silent_p.P8P|SIRPG_uc002wfo.1_Silent_p.P8P	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	8					blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						CAGGAGGATGGGGCCAGGAGG	0.552													23	63					0	0	0.00047179	0	0
PAK7	57144	broad.mit.edu	37	20	9624913	9624913	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr20:9624913G>A	uc002wnl.2	-	4	609	c.64C>T	c.(64-66)CAT>TAT	p.H22Y	PAK7_uc002wnk.2_Missense_Mutation_p.H22Y|PAK7_uc002wnj.2_Missense_Mutation_p.H22Y|PAK7_uc010gby.1_Missense_Mutation_p.H22Y	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	22	CRIB.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			AACCCAGTATGAACCCTGTGT	0.468													31	47					0	0	0.000692331	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18139841	18139841	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr20:18139841T>C	uc002wqj.2	+	5	1236	c.614T>C	c.(613-615)GTT>GCT	p.V205A	CSRP2BP_uc002wqk.2_Missense_Mutation_p.V77A|CSRP2BP_uc010zru.1_Missense_Mutation_p.V77A	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	205					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						TGGAAACTTGTTCATAACAAG	0.483													21	36					0	0	0.00152264	0	0
EDEM2	55741	broad.mit.edu	37	20	33703408	33703408	+	Missense_Mutation	SNP	G	A	A	rs146309337	byFrequency	TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr20:33703408G>A	uc002xbo.2	-	11	1665	c.1565C>T	c.(1564-1566)TCG>TTG	p.S522L	EDEM2_uc010zus.1_Missense_Mutation_p.S301L|EDEM2_uc002xbq.2_Missense_Mutation_p.S485L|EDEM2_uc010zut.1_Missense_Mutation_p.S481L|EDEM2_uc002xbp.2_Missense_Mutation_p.S370L|EDEM2_uc002xbn.2_Missense_Mutation_p.S370L|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_Missense_Mutation_p.S246L	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	522					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			CCATGGCCCCGAACTAACAGT	0.522													103	189					0	0	0.000781405	0	0
PHF20	51230	broad.mit.edu	37	20	34505530	34505530	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr20:34505530C>T	uc002xek.1	+	13	2061	c.1950C>T	c.(1948-1950)TTC>TTT	p.F650F		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	650					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					GCTATGACTTCGAGGTGGTCC	0.502													27	49					0	0	0.000878237	0	0
KCNB1	3745	broad.mit.edu	37	20	47989844	47989844	+	Silent	SNP	A	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr20:47989844A>C	uc002xur.1	-	2	2417	c.2253T>G	c.(2251-2253)GGT>GGG	p.G751G	KCNB1_uc002xus.1_Silent_p.G751G	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	751	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ACTGGTGGACACCCGCCTCAA	0.572													13	168					0	0	0.00285205	0	0
KCNG1	3755	broad.mit.edu	37	20	49626217	49626217	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr20:49626217G>A	uc002xwa.3	-	2	954	c.659C>T	c.(658-660)CCG>CTG	p.P220L	KCNG1_uc002xwb.2_Missense_Mutation_p.P220L	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	220	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						CCCCGAGTGCGGCCTCTCCAC	0.726													7	19					0	0	0.00198382	0	0
ZFP64	55734	broad.mit.edu	37	20	50705006	50705006	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr20:50705006G>A	uc002xwk.2	-	8	1502	c.1153C>T	c.(1153-1155)CCG>TCG	p.P385S	ZFP64_uc002xwj.2_Missense_Mutation_p.P166S	NM_199427	NP_955459	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform d	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CATTTGTACGGCCGCTCATCA	0.597													44	104					0	0	0.00285205	0	0
SLC5A3	6526	broad.mit.edu	37	21	35467791	35467791	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr21:35467791C>T	uc002yto.2	+	2	806	c.294C>T	c.(292-294)ATC>ATT	p.I98I	MRPS6_uc002ytp.2_Intron	NM_006933	NP_008864	P53794	SC5A3_HUMAN	solute carrier family 5 (inositol transporters),	98	Helical; (Potential).					integral to plasma membrane	myo-inositol:sodium symporter activity			ovary(2)	2						GGGTTTTCATCCCAATTTACA	0.478													279	232					0	0	0.000781405	0	0
XKR3	150165	broad.mit.edu	37	22	17288961	17288961	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr22:17288961C>T	uc002zlv.2	-	2	101	c.3G>A	c.(1-3)ATG>ATA	p.M1I	XKR3_uc011agf.1_Missense_Mutation_p.M1I	NM_175878	NP_787074	Q5GH77	XKR3_HUMAN	X Kell blood group precursor-related family,	1						integral to membrane|plasma membrane				large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ACACTGTCTCCATTCTCAGGG	0.388													37	120					0	0	0.00195071	0	0
MORC2	22880	broad.mit.edu	37	22	31330890	31330890	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr22:31330890G>A	uc003aje.1	-	20	3249	c.1885C>T	c.(1885-1887)CTG>TTG	p.L629L		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	691							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						TGCTGCACCAGAGGGGCAGGT	0.587													65	67					0	0	0.000781405	0	0
LIMK2	3985	broad.mit.edu	37	22	31662019	31662019	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr22:31662019C>T	uc003akh.2	+	8	1087	c.942C>T	c.(940-942)TCC>TCT	p.S314S	LIMK2_uc003akg.2_Silent_p.S231S|LIMK2_uc003aki.2_Silent_p.S68S|LIMK2_uc003akj.2_Silent_p.S293S|LIMK2_uc003akk.2_Silent_p.S293S|LIMK2_uc011aln.1_Silent_p.S231S	NM_005569	NP_005560	P53671	LIMK2_HUMAN	LIM domain kinase 2 isoform 2a	314						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2						GCTCAGAATCCCTTCGTTGTT	0.577													38	105					0	0	0.00111076	0	0
IL5RA	3568	broad.mit.edu	37	3	3137117	3137117	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr3:3137117G>A	uc011ask.1	-	9	1365	c.721C>T	c.(721-723)CCT>TCT	p.P241S	IL5RA_uc010hbq.2_Intron|IL5RA_uc010hbr.2_Intron|IL5RA_uc010hbs.2_Missense_Mutation_p.P241S|IL5RA_uc011asl.1_Missense_Mutation_p.P241S|IL5RA_uc011asm.1_Missense_Mutation_p.P241S|IL5RA_uc010hbt.2_Missense_Mutation_p.P241S|IL5RA_uc011asn.1_Missense_Mutation_p.P241S|IL5RA_uc010hbu.2_Missense_Mutation_p.P241S	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	241	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		TTCAGTGGAGGATTTATTTGA	0.388													18	16					0	0	0.00121646	0	0
CCR3	1232	broad.mit.edu	37	3	46306898	46306898	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr3:46306898C>T	uc003cpg.1	+	4	792	c.249C>T	c.(247-249)TTC>TTT	p.F83F	CCR3_uc003cpi.1_Silent_p.F83F|CCR3_uc003cpj.1_Silent_p.F83F|CCR3_uc003cpk.1_Silent_p.F104F|CCR3_uc010hjb.1_Silent_p.F101F|CCR3_uc003cpl.1_Silent_p.F116F	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	83	Helical; Name=2; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		ACCTGCTCTTCCTCGTCACCC	0.502													80	76					0	0	0.000781405	0	0
NISCH	11188	broad.mit.edu	37	3	52521644	52521644	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr3:52521644G>A	uc011beg.1	+	17	2208	c.2136G>A	c.(2134-2136)TGG>TGA	p.W712*	NISCH_uc003ded.3_Nonsense_Mutation_p.W712*|NISCH_uc003dee.3_Nonsense_Mutation_p.W201*|NISCH_uc003deg.1_RNA	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	712	Interaction with LIMK (By similarity).|Interaction with ITGA5 (By similarity).|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		AGGTGCTGTGGTGCTTCCTGA	0.562													25	15					0	0	0.000586117	0	0
FLNB	2317	broad.mit.edu	37	3	58155360	58155360	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr3:58155360C>T	uc003djj.2	+	45	7626	c.7461C>T	c.(7459-7461)TCC>TCT	p.S2487S	FLNB_uc010hne.2_Silent_p.S2518S|FLNB_uc003djk.2_Silent_p.S2476S|FLNB_uc010hnf.2_Silent_p.S2463S|FLNB_uc003djl.2_Silent_p.S2307S|FLNB_uc003djm.2_Silent_p.S2294S|uc003djn.2_Intron	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2487	Hinge 2 (By similarity).|Interaction with INPPL1.|Self-association site, tail (By similarity).			S -> C (in Ref. 11; AAA35505).	actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		AGACCTCATCCATCCTGGTGG	0.587													57	73					0	0	0.000781405	0	0
BOC	91653	broad.mit.edu	37	3	112968657	112968657	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr3:112968657G>A	uc003dzx.2	+	3	629	c.8G>A	c.(7-9)CGT>CAT	p.R3H	BOC_uc010hqi.2_Missense_Mutation_p.R3H|BOC_uc003dzy.2_Missense_Mutation_p.R3H|BOC_uc003dzz.2_Missense_Mutation_p.R3H|BOC_uc003dzw.1_Missense_Mutation_p.R3H|BOC_uc003eaa.1_Missense_Mutation_p.R3H	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	3					cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			ACCATGCTGCGTGGGACGATG	0.557													24	23					0	0	0.00127121	0	0
PARP14	54625	broad.mit.edu	37	3	122404049	122404049	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr3:122404049G>A	uc003efq.3	+	2	264	c.205G>A	c.(205-207)GAG>AAG	p.E69K		NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	69					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		GAAGGTTCTGGAGAGAAAAAA	0.393													27	22					0	0	0.00106085	0	0
MYLK	4638	broad.mit.edu	37	3	123376213	123376213	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr3:123376213G>T	uc003ego.2	-	24	4330	c.4048C>A	c.(4048-4050)CTG>ATG	p.L1350M	MYLK_uc010hrr.2_Translation_Start_Site|MYLK_uc011bjv.1_Missense_Mutation_p.L150M|MYLK_uc011bjw.1_Missense_Mutation_p.L1350M|MYLK_uc003egp.2_Missense_Mutation_p.L1281M|MYLK_uc003egq.2_Missense_Mutation_p.L1350M|MYLK_uc003egr.2_Missense_Mutation_p.L1281M|MYLK_uc003egs.2_Missense_Mutation_p.L1174M	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1350	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Fibronectin type-III.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TACCAGGACAGGGTCAGTGAG	0.547													20	21					7.45023e-12	3.80403e-11	0.00152264	1	0
KALRN	8997	broad.mit.edu	37	3	124438270	124438270	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr3:124438270C>T	uc003ehg.2	+	60	9041	c.8914C>T	c.(8914-8916)CCC>TCC	p.P2972S	KALRN_uc003ehk.2_Missense_Mutation_p.P1275S	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2971					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GCGGCCTATTCCCAATGTCAA	0.532													21	28					0	0	0.00047179	0	0
HES1	3280	broad.mit.edu	37	3	193854430	193854430	+	Nonsense_Mutation	SNP	A	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr3:193854430A>T	uc003ftq.1	+	2	369	c.133A>T	c.(133-135)AGA>TGA	p.R45*	HES1_uc011bst.1_Nonsense_Mutation_p.R45*	NM_005524	NP_005515	Q14469	HES1_HUMAN	hairy and enhancer of split 1	45	Basic motif.				endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)	2	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		TATGGAGAAAAGACGAAGAGC	0.428													11	16					0	0	0.00185496	0	0
LRRC15	131578	broad.mit.edu	37	3	194081290	194081290	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr3:194081290C>T	uc003ftu.2	-	2	569	c.483G>A	c.(481-483)CTG>CTA	p.L161L	LRRC15_uc003ftt.2_Silent_p.L167L	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	161	Extracellular (Potential).|LRR 5.					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		GGATGTATTCCAGGTGGTTGC	0.572													81	72					0	0	0.000781405	0	0
DOK7	285489	broad.mit.edu	37	4	3495069	3495069	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr4:3495069G>A	uc003ghd.2	+	7	1426	c.1356G>A	c.(1354-1356)CGG>CGA	p.R452R	DOK7_uc003ghe.2_Silent_p.R314R|DOK7_uc003ghf.2_Missense_Mutation_p.G194E|DOK7_uc003ghg.1_Silent_p.R142R	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	452					positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CGAGACGGCGGGGCCTGGTGA	0.776													7	6					0	0	0.000157383	0	0
ATP10D	57205	broad.mit.edu	37	4	47514627	47514627	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr4:47514627G>A	uc003gxk.1	+	2	234	c.70G>A	c.(70-72)GAT>AAT	p.D24N	ATP10D_uc003gxj.3_Missense_Mutation_p.D24N	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	24	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CAGGGATGATGATTCAGGGCC	0.527													11	68					0	0	0.000978159	0	0
C4orf40	401137	broad.mit.edu	37	4	71024103	71024103	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr4:71024103G>A	uc003hfa.3	+	4	207	c.134G>A	c.(133-135)CGG>CAG	p.R45Q	C4orf40_uc003hfb.3_Missense_Mutation_p.R45Q	NM_214711	NP_999876	Q6MZM9	CD040_HUMAN	hypothetical protein LOC401137 precursor	45						extracellular region					0						TATGGCATACGGAATTTACCA	0.433													46	52					0	0	0.000781405	0	0
AFM	173	broad.mit.edu	37	4	74350021	74350021	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr4:74350021G>A	uc003hhb.2	+	3	215	c.184G>A	c.(184-186)GAA>AAA	p.E62K		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	62	Albumin 1.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AACCTTTGAAGAAATGGAAAA	0.403													22	23					0	0	0.00188189	0	0
FSTL5	56884	broad.mit.edu	37	4	162841571	162841571	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr4:162841571C>T	uc003iqh.2	-	4	830	c.394G>A	c.(394-396)GAC>AAC	p.D132N	FSTL5_uc003iqi.2_Missense_Mutation_p.D131N|FSTL5_uc010iqv.2_Missense_Mutation_p.D131N	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	132	Kazal-like.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		AAGAAGCAGTCTTCATTGTGA	0.383													19	17					0	0	0.000958276	0	0
DNAH5	1767	broad.mit.edu	37	5	13727715	13727715	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:13727715C>T	uc003jfd.2	-	70	11976	c.11934G>A	c.(11932-11934)CCG>CCA	p.P3978P	DNAH5_uc003jfc.2_Silent_p.P146P	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3978					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GTTCCTCCTCCGGGTTTTCCT	0.423									Kartagener_syndrome				17	29					0	0	0.00074312	0	0
DNAH5	1767	broad.mit.edu	37	5	13911497	13911497	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:13911497G>A	uc003jfd.2	-	12	1684	c.1642C>T	c.(1642-1644)CAT>TAT	p.H548Y	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	548	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CAACCTACATGAAGGTCATTA	0.363									Kartagener_syndrome				14	49					0	0	0.000308642	0	0
FYB	2533	broad.mit.edu	37	5	39202529	39202529	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:39202529C>T	uc003jls.2	-	1	601	c.534G>A	c.(532-534)GGG>GGA	p.G178G	FYB_uc003jlt.2_Silent_p.G178G|FYB_uc003jlu.2_Silent_p.G178G|FYB_uc011cpl.1_Silent_p.G188G	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	178					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			ACATAAATTTCCCTTTAACCC	0.502													27	80					0	0	0.00127121	0	0
C7	730	broad.mit.edu	37	5	40981538	40981538	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:40981538G>A	uc003jmh.2	+	18	2509	c.2395G>A	c.(2395-2397)GAA>AAA	p.E799K		NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	799	Complement control factor I module 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				GGAGTGCGAGGAAGAAGGGTT	0.522													6	15					0	0	0.00116845	0	0
HCN1	348980	broad.mit.edu	37	5	45262228	45262228	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:45262228G>A	uc003jok.2	-	8	2493	c.2468C>T	c.(2467-2469)CCC>CTC	p.P823L		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	823	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GCCCGTTCCGGGGACCGCCGT	0.672													4	25					0	0	0.000602214	0	0
WNT8A	7478	broad.mit.edu	37	5	137419783	137419783	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:137419783G>A	uc003lcd.1	+	1	10	c.5G>A	c.(4-6)GGG>GAG	p.G2E	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_5'UTR|WNT8A_uc011cyk.1_5'UTR	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	2					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AGGGCGATGGGGAACCTGTTT	0.557													8	22					0	0	0.000274275	0	0
PSD2	84249	broad.mit.edu	37	5	139193814	139193814	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:139193814G>A	uc003leu.1	+	4	1086	c.881G>A	c.(880-882)GGG>GAG	p.G294E		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	294	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTCGGAGGGGTTGGAGCCT	0.632													25	56					0	0	0.00047179	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589663	140589663	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:140589663C>T	uc003liz.2	+	1	1373	c.1184C>T	c.(1183-1185)TCT>TTT	p.S395F	PCDHB12_uc011dak.1_Missense_Mutation_p.S58F	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	395	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGCTAAAATCTTCGGTAAAT	0.488													9	30					0	0	0.000673444	0	0
PCDHB14	56122	broad.mit.edu	37	5	140603964	140603964	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:140603964C>T	uc003ljb.2	+	1	887	c.887C>T	c.(886-888)CCA>CTA	p.P296L	PCDHB14_uc011dal.1_Missense_Mutation_p.P143L	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	296	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAATTAATCCAATATCTGGG	0.368													15	34					0	0	0.00244969	0	0
NMUR2	56923	broad.mit.edu	37	5	151784666	151784667	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:151784666_151784667CC>TT	uc003luv.2	-	1	174_175	c.8_9GG>AA	c.(7-9)GGG>GAA	p.G3E		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	3	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GTTTTTCCATCCCTGACATTAA	0.411													26	89					0	0	6.4e-05	0	0
FABP6	2172	broad.mit.edu	37	5	159661892	159661892	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:159661892G>A	uc003lya.1	+	3	437	c.309G>A	c.(307-309)GAG>GAA	p.E103E	FABP6_uc003lxx.1_Silent_p.E152E|FABP6_uc003lxz.1_Silent_p.E152E	NM_001445	NP_001436	P51161	FABP6_HUMAN	gastrotropin isoform 2	103					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGACCTCAGAGATCGTGGGTG	0.522													12	36					0	0	0.00185496	0	0
GABRB2	2561	broad.mit.edu	37	5	160758087	160758087	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:160758087C>T	uc003lys.1	-	9	1098	c.880G>A	c.(880-882)GAA>AAA	p.E294K	GABRB2_uc011deh.1_Missense_Mutation_p.E133K|GABRB2_uc003lyr.1_Missense_Mutation_p.E294K|GABRB2_uc003lyt.1_Missense_Mutation_p.E294K|GABRB2_uc010jiu.1_Missense_Mutation_p.E231K	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	294					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GGGAGAGTTTCCCGGAGGTGG	0.433													32	81					0	0	0.0024448	0	0
SLIT3	6586	broad.mit.edu	37	5	168123404	168123404	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr5:168123404C>T	uc003mab.2	-	28	3395	c.2975G>A	c.(2974-2976)CGG>CAG	p.R992Q	SLIT3_uc010jjg.2_Missense_Mutation_p.R999Q	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	992	EGF-like 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GATCTCACACCGCTGCCCCTC	0.587													10	43					0	0	0.000673444	0	0
TRIM10	10107	broad.mit.edu	37	6	30126183	30126183	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr6:30126183A>G	uc003npo.3	-	3	825	c.749T>C	c.(748-750)CTC>CCC	p.L250P	TRIM10_uc003npn.2_Missense_Mutation_p.L250P	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	250						cytoplasm	zinc ion binding				0						CACCGTCAGGAGCTCCCTTGC	0.532													61	75					0	0	0.000781405	0	0
PPP1R10	5514	broad.mit.edu	37	6	30576689	30576689	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr6:30576689A>C	uc003nqn.1	-	5	749	c.197T>G	c.(196-198)TTT>TGT	p.F66C	PPP1R10_uc010jsc.1_Translation_Start_Site	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	66	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						AACGTCAATAAATCTGCAGGC	0.473													3	82					0	0	6.4e-05	0	0
TREML2P1	221438	broad.mit.edu	37	6	41217211	41217211	+	RNA	SNP	T	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr6:41217211T>C	uc003oqe.1	+	1		c.97T>C				NR_002794				Homo sapiens TREM-like transcript 5 (TLT5) pseudogene mRNA, partial sequence.												0						TGAGCCTGGTTTCACCCAAGT	0.562													72	45					0	0	0.000781405	0	0
KLHDC3	116138	broad.mit.edu	37	6	42985004	42985004	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr6:42985004G>A	uc003otl.2	+	2	243	c.74G>A	c.(73-75)CGG>CAG	p.R25Q	KLHDC3_uc003otm.2_RNA|KLHDC3_uc010jyf.2_Missense_Mutation_p.R25Q|KLHDC3_uc003otn.2_5'UTR|KLHDC3_uc003oto.2_Missense_Mutation_p.R25Q	NM_057161	NP_476502	Q9BQ90	KLDC3_HUMAN	kelch domain containing 3	25	Kelch 1.				reciprocal meiotic recombination	cytoplasm|nuclear chromatin	chromatin binding|protein binding			upper_aerodigestive_tract(1)	1			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GTCGGGCATCGGGTATACTCC	0.572													11	119					0	0	0.000673444	0	0
PHF3	23469	broad.mit.edu	37	6	64408495	64408495	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr6:64408495T>A	uc003pep.1	+	7	3008	c.2982T>A	c.(2980-2982)AAT>AAA	p.N994K	PHF3_uc010kah.1_Missense_Mutation_p.N808K|PHF3_uc003pen.2_Missense_Mutation_p.N906K|PHF3_uc011dxs.1_Missense_Mutation_p.N263K	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	994	TFIIS central.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CTAAAAACAATGTAAGTATGC	0.289													11	37					0	0	0.000978159	0	0
COL9A1	1297	broad.mit.edu	37	6	70942348	70942348	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr6:70942348C>T	uc003pfg.3	-	36	2600	c.2441G>A	c.(2440-2442)GGA>GAA	p.G814E	COL9A1_uc003pfe.3_Missense_Mutation_p.G363E|COL9A1_uc003pff.3_Missense_Mutation_p.G571E	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	814	Triple-helical region (COL1).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						GCCACGAATTCCCATCTGGCC	0.592													21	102					0	0	0.00152264	0	0
ME1	4199	broad.mit.edu	37	6	83933597	83933597	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr6:83933597C>T	uc003pjy.2	-	12	1437	c.1331G>A	c.(1330-1332)GGA>GAA	p.G444E	ME1_uc011dzb.1_Missense_Mutation_p.G369E|ME1_uc011dzc.1_Missense_Mutation_p.G278E	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	444				NGQTLY -> DGRTLF (in Ref. 2; AAB01380).	carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	TAGGGTCTGTCCATTTGGAAG	0.438													4	23					0	0	0.00024832	0	0
SLC2A12	154091	broad.mit.edu	37	6	134349725	134349725	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr6:134349725G>A	uc003qem.1	-	2	1409	c.1238C>T	c.(1237-1239)TCC>TTC	p.S413F		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	413	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		TCTGCTATGGGAAGAAATCCC	0.453													27	39					0	0	0.000720815	0	0
KIAA1244	57221	broad.mit.edu	37	6	138607931	138607931	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr6:138607931C>T	uc003qhu.2	+	16	2663	c.2663C>T	c.(2662-2664)TCC>TTC	p.S888F		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	888					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GCGGGGAGCTCCAAAGGGCTG	0.567													48	52					0	0	0.000781405	0	0
PDE1C	5137	broad.mit.edu	37	7	31855585	31855585	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr7:31855585C>T	uc003tcm.1	-	15	2235	c.1766G>A	c.(1765-1767)GGG>GAG	p.G589E	PDE1C_uc003tcn.1_Missense_Mutation_p.G589E|PDE1C_uc003tco.1_Missense_Mutation_p.G649E|PDE1C_uc003tcr.2_Missense_Mutation_p.G589E|PDE1C_uc003tcs.2_Missense_Mutation_p.G589E	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	589					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			GGAGTTTTTCCCACGAGGGTT	0.458													70	189					0	0	0.000781405	0	0
VWC2	375567	broad.mit.edu	37	7	49842315	49842315	+	Silent	SNP	A	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr7:49842315A>T	uc003tot.1	+	3	1261	c.705A>T	c.(703-705)CCA>CCT	p.P235P		NM_198570	NP_940972	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	235	VWFC 2.				negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space					0						AGGTGTCTCCATGCGAGAGGT	0.458													49	115					0	0	0.000781405	0	0
ZNF735	730291	broad.mit.edu	37	7	63679742	63679742	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr7:63679742G>A	uc011kdn.1	+	4	313	c.313G>A	c.(313-315)GAT>AAT	p.D105N		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGCATAAAAGATTCACTCCA	0.338													24	111					0	0	0.000720815	0	0
TYW1B	441250	broad.mit.edu	37	7	72178689	72178689	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr7:72178689G>A	uc011kej.1	-	13	1419	c.1260C>T	c.(1258-1260)CTC>CTT	p.L420L	TYW1B_uc011keh.1_Silent_p.L258L|TYW1B_uc011kei.1_Silent_p.L46L	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	420					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GTTCTCCCACGAGGGACAATG	0.473													17	36					0	0	0.000586117	0	0
EMID2	136227	broad.mit.edu	37	7	101063375	101063375	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr7:101063375C>T	uc010lhy.1	+	2	468	c.276C>T	c.(274-276)CTC>CTT	p.L92L	EMID2_uc003uyo.1_Silent_p.L92L	NM_133457	NP_597714	Q96A83	EMID2_HUMAN	EMI domain containing 2	92	EMI.					collagen				ovary(1)	1	Lung NSC(181;0.215)					GCGCCAACCTCGTAAGGTAAA	0.657													21	38					0	0	0.00152264	0	0
CUX1	1523	broad.mit.edu	37	7	101840359	101840359	+	Silent	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr7:101840359C>T	uc003uyx.3	+	15	1706	c.1668C>T	c.(1666-1668)ATC>ATT	p.I556I	CUX1_uc003uys.3_Silent_p.I567I|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	556	CUT 1.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CTGCAGAAATCGCCCGGCAGG	0.537													58	138					0	0	0.000781405	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				26	51					0	0	0.00106085	0	0
OR6V1	346517	broad.mit.edu	37	7	142749478	142749478	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr7:142749478G>A	uc011ksv.1	+	1	41	c.41G>A	c.(40-42)GGC>GAC	p.G14D		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					GTCCTCTTGGGCTTCTCCTCC	0.438													46	129					0	0	0.000781405	0	0
NEIL2	252969	broad.mit.edu	37	8	11629028	11629028	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:11629028G>A	uc003wug.2	+	2	747	c.72G>A	c.(70-72)AAG>AAA	p.K24K	NEIL2_uc003wue.2_Silent_p.K24K|NEIL2_uc003wuf.2_Intron|NEIL2_uc011kxd.1_Silent_p.K24K	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	24					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		AGGTGGTCAAGACAGGGGGCA	0.572								BER_DNA_glycosylases					10	122					0	0	0.000673444	0	0
PEBP4	157310	broad.mit.edu	37	8	22582371	22582371	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:22582371C>T	uc003xcn.1	-	6	594	c.502G>A	c.(502-504)GAA>AAA	p.E168K		NM_144962	NP_659399	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	168						lysosome				ovary(1)|large_intestine(1)|breast(1)|skin(1)	4		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		GTTTTGTTTTCCTTGGGAAGG	0.537													13	57					0	0	0.00244969	0	0
ADAM28	10863	broad.mit.edu	37	8	24208805	24208805	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:24208805G>A	uc003xdy.2	+	20	2243	c.2160G>A	c.(2158-2160)AAG>AAA	p.K720K	ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Silent_p.K407K	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	720	Cytoplasmic (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AGATGGTAAAGGCTGTTCAAC	0.468													35	72					0	0	0.00148497	0	0
ADAM7	8756	broad.mit.edu	37	8	24300024	24300024	+	Missense_Mutation	SNP	C	T	T	rs137990671		TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:24300024C>T	uc003xeb.2	+	2	204	c.91C>T	c.(91-93)CGT>TGT	p.R31C	ADAM7_uc003xea.1_Missense_Mutation_p.R31C	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	31	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.R31C(1)		skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		ACAACTGGTTCGTCCTAAAAA	0.403													72	214					0	0	0.000781405	0	0
ADAM7	8756	broad.mit.edu	37	8	24300054	24300054	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:24300054C>T	uc003xeb.2	+	2	234	c.121C>T	c.(121-123)CGA>TGA	p.R41*	ADAM7_uc003xea.1_Nonsense_Mutation_p.R41*	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	41	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		GATACAGAAGCGAGATACTGG	0.403													53	160					0	0	0.000781405	0	0
ADAM7	8756	broad.mit.edu	37	8	24324332	24324332	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:24324332A>G	uc003xeb.2	+	6	523	c.410A>G	c.(409-411)GAC>GGC	p.D137G	ADAM7_uc003xea.1_Missense_Mutation_p.D137G	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	137	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		AGAATAAACGACCAAAGATAC	0.373													15	79					0	0	0.00244969	0	0
SNTG1	54212	broad.mit.edu	37	8	51571223	51571224	+	Splice_Site	DNP	GG	AA	AA			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:51571223_51571224GG>AA	uc010lxy.1	+	16	1409	c.1038_splice	c.e16+1	p.K346_splice	SNTG1_uc003xqs.1_Splice_Site_p.K346_splice|SNTG1_uc010lxz.1_Splice_Site_p.K346_splice|SNTG1_uc011ldl.1_Splice_Site	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1						cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				AGATCCTCAAGGTATGATCAAT	0.371													18	39					0	0	6.4e-05	0	0
KCNB2	9312	broad.mit.edu	37	8	73849017	73849017	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:73849017C>T	uc003xzb.2	+	3	2015	c.1427C>T	c.(1426-1428)GCC>GTC	p.A476V		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	476	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GGAGAGTCCGCCAACACAAAG	0.522													38	121					0	0	0.00148497	0	0
GDAP1	54332	broad.mit.edu	37	8	75276227	75276228	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:75276227_75276228CC>TT	uc003yah.2	+	6	781_782	c.702_703CC>TT	c.(700-705)GGCCAG>GGTTAG	p.Q235*	GDAP1_uc011lfj.1_Nonsense_Mutation_p.Q120*|GDAP1_uc003yai.2_Nonsense_Mutation_p.Q167*	NM_018972	NP_061845	Q8TB36	GDAP1_HUMAN	ganglioside-induced differentiation-associated	235	GST C-terminal.					cytoplasm					0	Breast(64;0.00769)	Myeloproliferative disorder(644;0.0122)	BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.104)|all cancers(69;0.234)			TAGAAGAGGGCCAGCAACCTTG	0.51													14	32					0	0	6.4e-05	0	0
SLC26A7	115111	broad.mit.edu	37	8	92330577	92330577	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:92330577C>T	uc003yex.2	+	6	889	c.611C>T	c.(610-612)CCA>CTA	p.P204L	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.P204L|SLC26A7_uc003yfa.2_Missense_Mutation_p.P204L	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	204	Helical; (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			ATGAAAATGCCATATATATCC	0.398													31	105					0	0	0.00058488	0	0
ZHX1	11244	broad.mit.edu	37	8	124266335	124266335	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:124266335C>G	uc003yqe.2	-	3	2282	c.1852G>C	c.(1852-1854)GAG>CAG	p.E618Q	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.E618Q|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.E618Q	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	618	Homeobox 3.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TTCTTCTTCTCTGTAAACCAA	0.373													18	75					0	0	0.00152264	0	0
KCNQ3	3786	broad.mit.edu	37	8	133192555	133192555	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:133192555G>A	uc003ytj.2	-	4	851	c.626C>T	c.(625-627)TCT>TTT	p.S209F	KCNQ3_uc010mdt.2_Missense_Mutation_p.S209F	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	209	Helical; Name=Segment S3; (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CACTGGCACAGAGGCAATCAG	0.572													29	82					0	0	0.00106085	0	0
COL22A1	169044	broad.mit.edu	37	8	139611073	139611073	+	Silent	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:139611073G>A	uc003yvd.2	-	61	4701	c.4254C>T	c.(4252-4254)ATC>ATT	p.I1418I	COL22A1_uc011ljo.1_Silent_p.I698I	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1418	Pro-rich.|Gly-rich.|Collagen-like 14.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TGTGGCCTGGGATTCCAGGGT	0.592										HNSCC(7;0.00092)			13	49					0	0	0.000308642	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433233	104433233	+	Silent	SNP	T	C	C			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr9:104433233T>C	uc004bbp.1	-	3	2062	c.1461A>G	c.(1459-1461)GGA>GGG	p.G487G	GRIN3A_uc004bbq.1_Silent_p.G487G	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	487	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TGACAATCTTTCCCCCCTGCC	0.502													7	161					0	0	0.000157383	0	0
TLR7	51284	broad.mit.edu	37	X	12905615	12905615	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chrX:12905615G>A	uc004cvc.2	+	3	2127	c.1988G>A	c.(1987-1989)AGT>AAT	p.S663N		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	663	Extracellular (Potential).|LRR 22.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	AATTCCCTAAGTTTCTTGCCT	0.353													75	32					0	0	0.000781405	0	0
ZNF711	7552	broad.mit.edu	37	X	84526007	84526007	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chrX:84526007G>A	uc004eeo.2	+	9	1806	c.1459G>A	c.(1459-1461)GAA>AAA	p.E487K	ZNF711_uc004eep.2_Missense_Mutation_p.E487K|ZNF711_uc004eeq.2_Missense_Mutation_p.E533K|ZNF711_uc011mqy.1_Missense_Mutation_p.E86K	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	487	C2H2-type 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						TGAAACTGCAGAACAAGGACT	0.418													6	3					0	0	0.00116845	0	0
TAF7L	54457	broad.mit.edu	37	X	100532669	100532669	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chrX:100532669C>T	uc004ehb.2	-	9	886	c.874G>A	c.(874-876)GAA>AAA	p.E292K	TAF7L_uc004eha.2_Missense_Mutation_p.E206K|TAF7L_uc004ehc.1_Missense_Mutation_p.E206K	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	292					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						CCTTGACTTTCTATTTCCTTG	0.463													38	30					0	0	0.00148497	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185816	127185816	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chrX:127185816C>T	uc004eum.2	-	1	567	c.370G>A	c.(370-372)GAA>AAA	p.E124K		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	124						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						AACATCATTTCTGCTAGCTTT	0.507													47	47					0	0	0.000781405	0	0
GPR112	139378	broad.mit.edu	37	X	135426719	135426719	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chrX:135426719C>T	uc004ezu.1	+	6	1145	c.854C>T	c.(853-855)TCA>TTA	p.S285L	GPR112_uc010nsb.1_Missense_Mutation_p.S80L|GPR112_uc010nsc.1_Missense_Mutation_p.S52L	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	285	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACAACCATATCATATTCCAAT	0.368													22	26					0	0	0.00229938	0	0
RYR2	6262	broad.mit.edu	37	1	237872838	237872839	+	Frame_Shift_Ins	INS	-	A	A			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr1:237872838_237872839insA	uc001hyl.1	+	70	10321_10322	c.10201_10202insA	c.(10201-10203)GAAfs	p.E3401fs	RYR2_uc010pxz.1_Frame_Shift_Ins_p.E356fs	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3401					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CATGGTGGCTGAAGTGTTTATC	0.455													13	15	---	---	---	---					
OR6C3	254786	broad.mit.edu	37	12	55726010	55726011	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr12:55726010_55726011delTG	uc010spj.1	+	1	526_527	c.526_527delTG	c.(526-528)TGTfs	p.C176fs		NM_054104	NP_473445	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCACTTTGCATGTGACTATTTT	0.436													10	323	---	---	---	---					
ADAM6	8755	broad.mit.edu	37	14	106774086	106774087	+	Splice_Site	INS	-	AGTAATACACGGCA	AGTAATACACGGCA			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr14:106774086_106774087insAGTAATACACGGCA	uc010tyt.1	-	430		c.15674_splice	c.e430+1							Parts of antibodies, mostly variable regions.												0						GCCTCTTGCACGTGTCCTCAGC	0.550													2	4	---	---	---	---					
AQR	9716	broad.mit.edu	37	15	35233143	35233143	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr15:35233143delT	uc001ziv.2	-	8	779	c.598delA	c.(598-600)ATTfs	p.I200fs		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	200						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TTCTTTTTAATCAAGTTCCAG	0.358													57	148	---	---	---	---					
ZNF395	55893	broad.mit.edu	37	8	28209226	28209228	+	In_Frame_Del	DEL	GCA	-	-	rs142343457	byFrequency	TCGA-EE-A17Y-06A-11D-A196-08	TCGA-EE-A17Y-10B-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	82b28667-3205-4d4b-8c3e-2bde4ccbd2f6	70f95dbd-6497-4bb0-a27f-4676281532d1	g.chr8:28209226_28209228delGCA	uc003xgq.2	-	7	1105_1107	c.1017_1019delTGC	c.(1015-1020)GCTGCC>GCC	p.339_340AA>A	ZNF395_uc003xgt.2_In_Frame_Del_p.339_340AA>A|ZNF395_uc003xgr.2_In_Frame_Del_p.339_340AA>A|ZNF395_uc003xgs.2_In_Frame_Del_p.339_340AA>A	NM_018660	NP_061130	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	339_340					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GGTGCCTgcggcagcagcagcag	0.507													8	156	---	---	---	---					
