Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NOC2L	26155	broad.mit.edu	37	1	881015	881016	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:881015_881016GG>AA	uc001abz.3	-	17	1994_1995	c.1935_1936CC>TT	c.(1933-1938)TTCCCT>TTTTCT	p.P646S	NOC2L_uc001aby.3_Missense_Mutation_p.P443S|NOC2L_uc009vjq.2_Missense_Mutation_p.P646S	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	646	Asp/Glu-rich (acidic).					nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		TTGATCTCAGGGAAGTTCAGGT	0.569													5	74					0	0	0.004672	0	0
AGRN	375790	broad.mit.edu	37	1	981167	981167	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:981167G>T	uc001ack.1	+	15	2641	c.2591G>T	c.(2590-2592)GGG>GTG	p.G864V		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	864	Laminin EGF-like 2.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CAGATGACGGGGCTGTGCTCG	0.667													12	70					3.27435e-08	3.5443e-08	0.002450	1	0
SDF4	51150	broad.mit.edu	37	1	1164002	1164002	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:1164002G>A	uc001adh.3	-	2	501	c.172C>T	c.(172-174)CCC>TCC	p.P58S	SDF4_uc001adi.3_Missense_Mutation_p.P58S|SDF4_uc009vjv.2_Intron|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	58					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		TGGTCTGGGGGCAGGATCTCA	0.617													8	39					0	0	0.004482	0	0
ATAD3C	219293	broad.mit.edu	37	1	1403879	1403879	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:1403879C>T	uc001aft.2	+	12	2200	c.1205C>T	c.(1204-1206)CCT>CTT	p.P402L		NM_001039211	NP_001034300	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	402							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGGGAGAGGCCTGGGCCCGAG	0.672													3	16					0	0	0.004672	0	0
SKI	6497	broad.mit.edu	37	1	2160544	2160544	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:2160544C>T	uc001aja.3	+	1	411	c.339C>T	c.(337-339)TTC>TTT	p.F113F		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	113					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		TCTCGTGCTTCGTGGTGGGAG	0.672													4	24					0	0	0.000602	0	0
RER1	11079	broad.mit.edu	37	1	2330920	2330920	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:2330920C>T	uc001aje.1	+	4	444	c.253C>T	c.(253-255)CCC>TCC	p.P85S	RER1_uc001ajf.1_Missense_Mutation_p.P85S	NM_007033	NP_008964	O15258	RER1_HUMAN	RER1 retention in endoplasmic reticulum 1	85					retrograde vesicle-mediated transport, Golgi to ER	integral to Golgi membrane					0	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.28e-37)|OV - Ovarian serous cystadenocarcinoma(86;8.29e-23)|GBM - Glioblastoma multiforme(42;4.71e-08)|Colorectal(212;4.73e-05)|COAD - Colon adenocarcinoma(227;0.00021)|Kidney(185;0.00116)|BRCA - Breast invasive adenocarcinoma(365;0.00459)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0182)|Lung(427;0.204)		TTTTCTTTCTCCCAAAGTGGA	0.488													5	57					0	0	0.001984	0	0
MMEL1	79258	broad.mit.edu	37	1	2538438	2538438	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:2538438C>T	uc001ajy.2	-	7	820	c.606G>A	c.(604-606)GCG>GCA	p.A202A	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	202	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		ACCTGTCCATCGCCACCGGCC	0.632													5	62					0	0	0.001168	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938862	2938862	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:2938862C>T	uc001ajz.2	+	1	817	c.612C>T	c.(610-612)TTC>TTT	p.F204F		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	204						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GCCACACCTTCCCCTGCCAGC	0.642													8	51					0	0	0.008291	0	0
PRDM16	63976	broad.mit.edu	37	1	3328135	3328135	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:3328135C>T	uc001akf.2	+	9	1454	c.1374C>T	c.(1372-1374)GCC>GCT	p.A458A	PRDM16_uc001akc.2_Silent_p.A458A|PRDM16_uc001akd.2_Silent_p.A458A|PRDM16_uc001ake.2_Silent_p.A458A|PRDM16_uc009vlh.2_Silent_p.A159A	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	458					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCATCTTTGCCCCGGGCCTGC	0.617			T	EVI1	MDS|AML								7	34					0	0	0.003080	0	0
TP73	7161	broad.mit.edu	37	1	3644768	3644768	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:3644768C>T	uc001akp.2	+	9	1171	c.1061C>T	c.(1060-1062)ACG>ATG	p.T354M	TP73_uc001akq.2_Missense_Mutation_p.T354M|TP73_uc010nzj.1_Missense_Mutation_p.T305M|TP73_uc001akr.2_Missense_Mutation_p.T305M|TP73_uc009vlk.1_Missense_Mutation_p.T305M|TP73_uc001aks.2_Missense_Mutation_p.T305M|TP73_uc010nzk.1_Missense_Mutation_p.T283M|TP73_uc010nzl.1_Translation_Start_Site	NM_005427	NP_005418	O15350	P73_HUMAN	tumor protein p73 isoform a	354	Oligomerization (Potential).|Interaction with HIPK2.				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			ovary(1)|lung(1)	2	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		GACGAGGACACGTACTACCTT	0.677													12	58					0	0	0.002450	0	0
KIAA0562	9731	broad.mit.edu	37	1	3732052	3732052	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:3732052G>A	uc001aky.2	-	22	3051	c.2692C>T	c.(2692-2694)CCC>TCC	p.P898S	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	898						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		GACCCCAAGGGGCCTGATGCG	0.652													4	32					0	0	0.000602	0	0
KIAA0562	9731	broad.mit.edu	37	1	3753249	3753249	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:3753249G>A	uc001aky.2	-	10	1486	c.1127C>T	c.(1126-1128)TCC>TTC	p.S376F	KIAA0562_uc010nzm.1_RNA|KIAA0562_uc001akz.2_Missense_Mutation_p.S376F	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	376						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		GTAGGGCAGGGACTCTGCCTG	0.552													6	22					0	0	0.001168	0	0
CHD5	26038	broad.mit.edu	37	1	6169886	6169886	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:6169886C>T	uc001amb.1	-	38	5647	c.5547G>A	c.(5545-5547)GGG>GGA	p.G1849G	CHD5_uc001alz.1_Silent_p.G706G|CHD5_uc001ama.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1849					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CAGGCTTGTTCCCAGCAAGGG	0.682													11	118					0	0	0.010729	0	0
CHD5	26038	broad.mit.edu	37	1	6214775	6214776	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:6214775_6214776GG>AA	uc001amb.1	-	5	789_790	c.689_690CC>TT	c.(688-690)CCC>CTT	p.P230L		NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	230					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GCACCTGCGGGGGGCTGACGGC	0.545													4	35					0	0	0.004672	0	0
DNAJC11	55735	broad.mit.edu	37	1	6705993	6705993	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:6705993G>A	uc001aof.2	-	8	856	c.750C>T	c.(748-750)ATC>ATT	p.I250I	DNAJC11_uc010nzt.1_Silent_p.I212I|DNAJC11_uc001aog.2_Silent_p.I250I|DNAJC11_uc010nzu.1_Silent_p.I160I	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	250					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCGGGTCGGATTCCACGGG	0.542													19	81					0	0	0.010504	0	0
ENO1	2023	broad.mit.edu	37	1	8922989	8922989	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:8922989G>A	uc001apj.1	-	11	1343	c.1192C>T	c.(1192-1194)CCT>TCT	p.P398S	ENO1_uc001api.1_Missense_Mutation_p.P302S|ENO1_uc001apk.1_Missense_Mutation_p.P343S|ENO1_uc001apl.1_Intron|ENO1_uc009vmi.1_Missense_Mutation_p.P355S|ENO1_uc009vmj.1_Intron|ENO1_uc009vmk.1_Missense_Mutation_p.P272S	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	398					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		GATCGGCAAGGGGCACCAGTC	0.562											OREG0013068	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	12					0	0	0.009096	0	0
CA6	765	broad.mit.edu	37	1	9034706	9034706	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:9034706G>A	uc001apm.2	+	8	894	c.870G>A	c.(868-870)CAG>CAA	p.Q290Q	CA6_uc009vmn.2_Silent_p.Q230Q	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	290					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		CTGAATTCCAGTTTTACCTAC	0.388													5	18					0	0	0.003080	0	0
TMEM201	199953	broad.mit.edu	37	1	9661392	9661392	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:9661392C>T	uc001apz.2	+	5	848	c.836C>T	c.(835-837)CCC>CTC	p.P279L	TMEM201_uc001apy.2_Missense_Mutation_p.P279L	NM_001130924	NP_001124396	Q5SNT2	TM201_HUMAN	transmembrane protein 201 isoform 1	279						integral to membrane|nuclear inner membrane					0	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		GGCCTACTCCCCGAGCACATG	0.682													14	78					0	0	0.003163	0	0
KIF1B	23095	broad.mit.edu	37	1	10316344	10316344	+	Missense_Mutation	SNP	C	T	T	rs143654307		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:10316344C>T	uc001aqx.3	+	3	348	c.146C>T	c.(145-147)TCC>TTC	p.S49F	KIF1B_uc001aqv.3_Missense_Mutation_p.S49F|KIF1B_uc001aqw.3_Missense_Mutation_p.S49F|KIF1B_uc001aqy.2_Missense_Mutation_p.S49F|KIF1B_uc001aqz.2_Missense_Mutation_p.S49F|KIF1B_uc001ara.2_Missense_Mutation_p.S49F|KIF1B_uc001arb.2_Missense_Mutation_p.S49F|KIF1B_uc009vmt.2_RNA	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	49	Kinesin-motor.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GCTCCAAAGTCCTTCAGCTTC	0.403													12	47					0	0	0.013537	0	0
C1orf127	148345	broad.mit.edu	37	1	11008428	11008428	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:11008428G>A	uc010oao.1	-	8	1322	c.1317C>T	c.(1315-1317)TTC>TTT	p.F439F	C1orf127_uc001arr.1_Silent_p.F421F|C1orf127_uc001ars.1_Silent_p.F413F	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	439										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		CCAATGGCTGGAACTCCTCAC	0.647													5	33					0	0	0.000602	0	0
PTCHD2	57540	broad.mit.edu	37	1	11589905	11589905	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:11589905G>A	uc001ash.3	+	15	3129	c.2991G>A	c.(2989-2991)GGG>GGA	p.G997G		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	997	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CGGGCTGCGGGAAGCCGGCGG	0.627													6	45					0	0	0.004482	0	0
VPS13D	55187	broad.mit.edu	37	1	12343669	12343669	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:12343669C>T	uc001atv.2	+	21	5651	c.5510C>T	c.(5509-5511)TCC>TTC	p.S1837F	VPS13D_uc001atw.2_Missense_Mutation_p.S1837F|VPS13D_uc001atx.2_Missense_Mutation_p.S1025F	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1837					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GGAATCGGCTCCACTGCAGAC	0.483													10	100					0	0	0.013537	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12853598	12853598	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:12853598T>G	uc001auj.1	+	2	325	c.222T>G	c.(220-222)CAT>CAG	p.H74Q		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	74											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGACGCTTCATTTGGAGACCT	0.557													8	106					0	0	0.013537	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887503	12887503	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:12887503C>T	uc001auk.2	-	3	550	c.354G>A	c.(352-354)AGG>AGA	p.R118R		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	118											0						CATCCAGAGTCCTGTTCTTGA	0.478													59	260					0	0	0.014410	0	0
LOC649330	649330	broad.mit.edu	37	1	12907304	12907304	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:12907304C>T	uc009vno.2	-	1	934	c.839G>A	c.(838-840)GGA>GAA	p.G280E	HNRNPCL1_uc010obf.1_Missense_Mutation_p.G280E	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	280							nucleic acid binding|nucleotide binding				0						GTCATCCTCTCCTTCCTCAGC	0.478													23	169					0	0	0.005443	0	0
LOC649330	649330	broad.mit.edu	37	1	12907509	12907509	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:12907509C>T	uc009vno.2	-	1	729	c.634G>A	c.(634-636)GGA>AGA	p.G212R	HNRNPCL1_uc010obf.1_Missense_Mutation_p.E212K	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	212							nucleic acid binding|nucleotide binding				0						ACCTCTACCTCTTGTTTGCTC	0.448													10	98					0	0	0.013537	0	0
LOC649330	649330	broad.mit.edu	37	1	12907793	12907793	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:12907793C>T	uc009vno.2	-	1	445	c.350G>A	c.(349-351)CGG>CAG	p.R117Q	HNRNPCL1_uc010obf.1_Missense_Mutation_p.R117Q	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	117							nucleic acid binding|nucleotide binding				0						ATAATAATCCCGTTGAAAGCC	0.512													12	58					0	0	0.010729	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921458	12921458	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:12921458G>A	uc001aum.1	+	4	1336	c.1249G>A	c.(1249-1251)GAG>AAG	p.E417K		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	417											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCCCTGAGGAGAGTTTGAA	0.537													18	69					0	0	0.014323	0	0
LOC440563	440563	broad.mit.edu	37	1	13183370	13183370	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:13183370C>T	uc010obg.1	-	1	598	c.503G>A	c.(502-504)GGA>GAA	p.G168E		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	168						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CTTGGAAGATCCCCGCTTTCC	0.493													21	455					0	0	0.004656	0	0
PRDM2	7799	broad.mit.edu	37	1	14059318	14059318	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:14059318C>T	uc001avi.2	+	4	1028	c.172C>T	c.(172-174)CCA>TCA	p.P58S	PRDM2_uc001avg.2_Missense_Mutation_p.P58S|PRDM2_uc001avh.2_Missense_Mutation_p.P58S|PRDM2_uc001avj.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	58	SET.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		AAAATTTGGGCCATTTGTTGG	0.289													4	44					0	0	0.000602	0	0
KAZ	23254	broad.mit.edu	37	1	15392187	15392187	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:15392187C>T	uc001avm.3	+	8	1441	c.1160C>T	c.(1159-1161)TCC>TTC	p.S387F	KAZ_uc009vog.1_Missense_Mutation_p.S387F|KAZ_uc010obj.1_Missense_Mutation_p.S387F|KAZ_uc001avo.2_Missense_Mutation_p.S381F|KAZ_uc001avp.2_Missense_Mutation_p.S293F|KAZ_uc001avq.2_Missense_Mutation_p.S293F|KAZ_uc001avr.2_3'UTR	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	387					keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						GGATTCGGCTCCATCTCCCGC	0.557													7	44					0	0	0.001984	0	0
AGMAT	79814	broad.mit.edu	37	1	15906600	15906600	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:15906600C>T	uc001awv.1	-	3	656	c.513G>A	c.(511-513)GCG>GCA	p.A171A	DNAJC16_uc001awu.2_Intron	NM_024758	NP_079034	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase) precursor	171					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			skin(1)	1		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		TTTTTGCCATCGCTTGCAATA	0.403													8	40					0	0	0.008291	0	0
SPEN	23013	broad.mit.edu	37	1	16202812	16202812	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:16202812C>T	uc001axk.1	+	3	724	c.520C>T	c.(520-522)CGA>TGA	p.R174*	SPEN_uc010obp.1_Nonsense_Mutation_p.R133*	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	174	Arg-rich.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TAGAGATCCTCGAGAGCGGAC	0.502													5	23					0	0	0.000602	0	0
CLCNKB	1188	broad.mit.edu	37	1	16373114	16373114	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:16373114C>T	uc001axw.3	+	4	394	c.314C>T	c.(313-315)TCT>TTT	p.S105F	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.S105F|CLCNKB_uc001axy.3_5'Flank	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	105	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCTCGTCTCTTTCTCTTCA	0.602													8	32					0	0	0.004482	0	0
ATP13A2	23400	broad.mit.edu	37	1	17313448	17313448	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:17313448G>A	uc001baa.2	-	27	3277	c.3087C>T	c.(3085-3087)TTC>TTT	p.F1029F	ATP13A2_uc001azz.1_Silent_p.F176F|ATP13A2_uc001bab.2_Silent_p.F1024F|ATP13A2_uc001bac.2_Silent_p.F985F	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	1029	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		TCAGAGGCACGAACCTGGGGG	0.617													7	45					0	0	0.001984	0	0
ACTL8	81569	broad.mit.edu	37	1	18152362	18152362	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:18152362C>T	uc001bat.2	+	3	665	c.449C>T	c.(448-450)TCT>TTT	p.S150F		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	150						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		GTGGTTGATTCTGGCTATGGC	0.637											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	27					0	0	0.000602	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808829	18808829	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:18808829G>A	uc001bax.2	+	1	1406	c.1354G>A	c.(1354-1356)GAG>AAG	p.E452K	KLHDC7A_uc009vpg.2_Missense_Mutation_p.E234K	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	452						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCCTGAAAGAGGCGGCCTA	0.632													5	81					0	0	0.000602	0	0
TAS1R2	80834	broad.mit.edu	37	1	19181226	19181226	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:19181226G>A	uc001bba.1	-	3	739	c.738C>T	c.(736-738)AAC>AAT	p.N246N		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	246	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TCATGTTCTGGTTGGGCTGCA	0.652													5	18					0	0	0.000602	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19204035	19204035	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:19204035G>A	uc001bbb.2	-	10	1288	c.1012C>T	c.(1012-1014)CGC>TGC	p.R338C	ALDH4A1_uc010ocu.1_Missense_Mutation_p.R278C|ALDH4A1_uc001bbc.2_Missense_Mutation_p.R338C	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	338					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	AAGGCTGAGCGGAGGGTCCCG	0.657													4	17					0	0	0.000602	0	0
UBR4	23352	broad.mit.edu	37	1	19430687	19430687	+	Silent	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:19430687A>G	uc001bbi.2	-	87	12796	c.12792T>C	c.(12790-12792)GGT>GGC	p.G4264G	UBR4_uc010ocw.1_5'Flank|UBR4_uc001bbg.2_5'UTR|UBR4_uc001bbh.2_5'UTR	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	4264					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCAGCACAGTACCCACCAAGC	0.512													11	55					0	0	0.013537	0	0
UBR4	23352	broad.mit.edu	37	1	19442124	19442124	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:19442124G>A	uc001bbi.2	-	74	10835	c.10831C>T	c.(10831-10833)CGC>TGC	p.R3611C	UBR4_uc001bbj.1_Missense_Mutation_p.R26C	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3611					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TTGTGCCAGCGAGCTGGCCTA	0.483													19	95					0	0	0.010504	0	0
AKR7A3	22977	broad.mit.edu	37	1	19611564	19611564	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:19611564G>A	uc001bbv.1	-	4	629	c.552C>T	c.(550-552)TTC>TTT	p.F184F		NM_012067	NP_036199	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3	184					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGAGGCAGGGGAAGAGCTCCG	0.582													7	61					0	0	0.004482	0	0
EIF4G3	8672	broad.mit.edu	37	1	21221991	21221991	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:21221991G>A	uc001bec.2	-	12	2091	c.1835C>T	c.(1834-1836)TCC>TTC	p.S612F	EIF4G3_uc010odi.1_Missense_Mutation_p.S216F|EIF4G3_uc010odj.1_Missense_Mutation_p.S611F|EIF4G3_uc009vpz.2_Missense_Mutation_p.S332F|EIF4G3_uc001bed.2_Missense_Mutation_p.S612F|EIF4G3_uc001bef.2_Missense_Mutation_p.S611F|EIF4G3_uc001bee.2_Missense_Mutation_p.S618F	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	612					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		AGGCTTCCAGGATTCTAGAAA	0.333													11	38					0	0	0.001855	0	0
HSPG2	3339	broad.mit.edu	37	1	22188579	22188579	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:22188579G>A	uc001bfj.2	-	38	4810	c.4770C>T	c.(4768-4770)TTC>TTT	p.F1590F	HSPG2_uc009vqd.2_Silent_p.F1591F	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	1590	Laminin EGF-like 10.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AAAGCTCGCAGAACTCCCCTG	0.502													13	48					0	0	0.001855	0	0
KDM1A	23028	broad.mit.edu	37	1	23398665	23398665	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:23398665C>T	uc001bgi.2	+	12	1674	c.1525C>T	c.(1525-1527)CAG>TAG	p.Q509*	KDM1A_uc001bgj.2_Nonsense_Mutation_p.Q533*	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	509	Potential.|Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						AGAAAAACTTCAGGAGTTGGA	0.388													4	15					0	0	0.009096	0	0
HTR1D	3352	broad.mit.edu	37	1	23520593	23520594	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:23520593_23520594GG>AA	uc001bgn.2	-	1	629_630	c.119_120CC>TT	c.(118-120)TCC>TTT	p.S40F		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	40	Helical; Name=1; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	CCACGGCAAGGGAGATCTTGAG	0.579													6	78					0	0	0.004672	0	0
MYOM3	127294	broad.mit.edu	37	1	24392449	24392449	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:24392449G>A	uc001bin.3	-	29	3629	c.3466C>T	c.(3466-3468)CAG>TAG	p.Q1156*	MYOM3_uc001bil.3_Nonsense_Mutation_p.Q49*|MYOM3_uc001bim.3_Nonsense_Mutation_p.Q813*|MYOM3_uc001bio.2_Nonsense_Mutation_p.Q1156*	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1156	Ig-like C2-type 3.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TCTGCCCTCTGGAAGAACCAC	0.517													19	98					0	0	0.014323	0	0
IL28RA	163702	broad.mit.edu	37	1	24484345	24484345	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:24484345G>A	uc001bis.2	-	7	851	c.838C>T	c.(838-840)CAG>TAG	p.Q280*	IL28RA_uc001bir.2_Intron|IL28RA_uc001bit.2_Missense_Mutation_p.S236L|IL28RA_uc001biu.2_Nonsense_Mutation_p.Q196*	NM_170743	NP_734464	Q8IU57	I28RA_HUMAN	interleukin 28 receptor, alpha isoform 1	280	Cytoplasmic (Potential).				cytokine-mediated signaling pathway|negative regulation of cell proliferation|regulation of defense response to virus by host	interleukin-28 receptor complex	protein binding|receptor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00117)|all_lung(284;0.00151)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.21e-24)|Colorectal(126;6.61e-08)|COAD - Colon adenocarcinoma(152;3.56e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00918)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.185)		CTGCTGGGCTGAAAGGTTGCC	0.512													12	96					0	0	0.001855	0	0
SRRM1	10250	broad.mit.edu	37	1	24979433	24979433	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:24979433C>T	uc001bjm.2	+	8	1174	c.950C>T	c.(949-951)CCA>CTA	p.P317L	SRRM1_uc010oel.1_Missense_Mutation_p.P317L|SRRM1_uc009vrh.1_Missense_Mutation_p.P278L|SRRM1_uc009vri.1_Missense_Mutation_p.P234L|SRRM1_uc010oem.1_RNA	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	317	Pro-rich.|Necessary for speckles and matrix localization.|Arg-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		CGGCCAAGCCCAAGAAGGCGG	0.463													6	40					0	0	0.001984	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28271853	28271853	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:28271853C>T	uc001bpg.2	+	2	363	c.172C>T	c.(172-174)CCC>TCC	p.P58S	SMPDL3B_uc001bpf.2_Missense_Mutation_p.P58S|SMPDL3B_uc010ofq.1_5'UTR|SMPDL3B_uc010ofr.1_Missense_Mutation_p.P58S	NM_014474	NP_055289	Q92485	ASM3B_HUMAN	acid sphingomyelinase-like phosphodiesterase 3B	58					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			ovary(3)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		CGACGCAGGCCCCTGGGGTGA	0.577													12	34					0	0	0.002450	0	0
PTPRU	10076	broad.mit.edu	37	1	29581888	29581889	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:29581888_29581889GG>AA	uc001bru.2	+	2	285_286	c.175_176GG>AA	c.(175-177)GGC>AAC	p.G59N	PTPRU_uc001brv.2_Missense_Mutation_p.G59N|PTPRU_uc001brw.2_Missense_Mutation_p.G59N|PTPRU_uc009vtq.2_Missense_Mutation_p.G59N|PTPRU_uc009vtr.2_Missense_Mutation_p.G59N	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	59	Extracellular (Potential).|MAM.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		AATCCACCCTGGCACCCGGGCA	0.505													11	50					0	0	0.004672	0	0
PUM1	9698	broad.mit.edu	37	1	31467992	31467992	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:31467992G>A	uc001bsi.1	-	6	909	c.796C>T	c.(796-798)CTA>TTA	p.L266L	PUM1_uc001bsf.1_5'Flank|PUM1_uc001bsg.1_Silent_p.L78L|PUM1_uc001bsh.1_Silent_p.L266L|PUM1_uc001bsj.1_Silent_p.L266L|PUM1_uc010oga.1_Silent_p.L170L|PUM1_uc001bsk.1_Silent_p.L302L|PUM1_uc010ogb.1_Silent_p.L206L	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	266					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		AAATCTCCTAGCTTATCTCCA	0.428													23	121					0	0	0.003330	0	0
SPOCD1	90853	broad.mit.edu	37	1	32259353	32259353	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:32259353C>T	uc001bts.1	-	12	2587	c.2529G>A	c.(2527-2529)CAG>CAA	p.Q843Q	SPOCD1_uc001btr.1_5'Flank|SPOCD1_uc001btt.2_Silent_p.Q148Q|SPOCD1_uc001btu.2_Silent_p.Q843Q|SPOCD1_uc001btv.2_Silent_p.Q336Q	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	843					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CACACCTGTCCTGTGGTTCCG	0.557													12	55					0	0	0.001855	0	0
SPOCD1	90853	broad.mit.edu	37	1	32279800	32279800	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:32279800C>T	uc001bts.1	-	2	1193	c.1135G>A	c.(1135-1137)GGA>AGA	p.G379R	SPOCD1_uc001btu.2_Missense_Mutation_p.G379R|SPOCD1_uc001btv.2_Intron	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	379					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		GCAGCGAGTCCTTGCTCCAGC	0.682													3	9					0	0	0.004672	0	0
SPOCD1	90853	broad.mit.edu	37	1	32280501	32280501	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:32280501C>T	uc001bts.1	-	2	492	c.434G>A	c.(433-435)AGA>AAA	p.R145K	SPOCD1_uc001btu.2_Missense_Mutation_p.R145K|SPOCD1_uc001btv.2_Intron	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	145					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		GGCCAGAGCTCTCTCTGGGAG	0.587													9	76					0	0	0.008291	0	0
MARCKSL1	65108	broad.mit.edu	37	1	32800664	32800664	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:32800664G>A	uc001bvd.2	-	2	322	c.122C>T	c.(121-123)TCC>TTC	p.S41F		NM_023009	NP_075385	P49006	MRP_HUMAN	MARCKS-like 1	41						plasma membrane	calmodulin binding			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACCCTTGGGGGATAAGTCTCC	0.637													21	63					0	0	0.003330	0	0
RBBP4	5928	broad.mit.edu	37	1	33134686	33134686	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:33134686C>T	uc001bvr.2	+	6	873	c.714C>T	c.(712-714)CTC>CTT	p.L238L	RBBP4_uc001bvs.2_Silent_p.L237L|RBBP4_uc010ohj.1_5'UTR|RBBP4_uc010ohk.1_Silent_p.L203L	NM_005610	NP_005601	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4 isoform a	238	WD 3.				cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				GGCATCTACTCCATGAGTCTC	0.418													10	54					0	0	0.013537	0	0
HPCA	3208	broad.mit.edu	37	1	33354677	33354677	+	Missense_Mutation	SNP	G	A	A	rs147332564		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:33354677G>A	uc001bwh.2	+	2	218	c.178G>A	c.(178-180)GAC>AAC	p.D60N		NM_002143	NP_002134	P84074	HPCA_HUMAN	hippocalcin	60	EF-hand 2.						actin binding|calcium ion binding	p.D60D(1)		ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				TCCCTATGGTGACGCCTCCAA	0.537													6	66					0	0	0.003080	0	0
ADC	113451	broad.mit.edu	37	1	33562307	33562307	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:33562307G>A	uc001bwr.2	+	9	1341	c.754_splice	c.e9-1	p.I252_splice	ADC_uc001bws.2_Splice_Site_p.I252_splice|ADC_uc009vue.2_Splice_Site_p.I252_splice|ADC_uc001bwt.1_Splice_Site_p.I157_splice|ADC_uc001bwu.2_Splice_Site_p.I157_splice|ADC_uc001bwv.2_Splice_Site_p.I157_splice|ADC_uc001bww.2_Splice_Site_p.I157_splice|ADC_uc001bwx.1_Splice_Site_p.I229_splice|ADC_uc001bwz.1_Splice_Site_p.I252_splice|ADC_uc009vuf.1_Splice_Site_p.I94_splice|ADC_uc001bwy.1_Splice_Site_p.I101_splice|ADC_uc009vug.2_Splice_Site_p.I252_splice	NM_052998	NP_443724	Q96A70	ADC_HUMAN	ODC antizyme inhibitor-2						polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	CCTCCTACCAGATTGCTTCCG	0.502													11	33					0	0	0.010729	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33960692	33960692	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:33960692C>T	uc001bxj.3	+	8	2915	c.2748C>T	c.(2746-2748)TCC>TCT	p.S916S	ZSCAN20_uc009vui.2_Silent_p.S915S	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	916	C2H2-type 6.				viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GTAAGAGCTCCACCCTGGCCA	0.517													10	66					0	0	0.008291	0	0
CSMD2	114784	broad.mit.edu	37	1	33987127	33987127	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:33987127G>A	uc001bxn.1	-	67	10130	c.10101C>T	c.(10099-10101)GCC>GCT	p.A3367A	CSMD2_uc001bxm.1_Silent_p.A3511A	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3367	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGATGAAGGTGGCTCCGGAGG	0.577													7	53					0	0	0.004482	0	0
CSMD2	114784	broad.mit.edu	37	1	34035053	34035053	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:34035053G>A	uc001bxn.1	-	53	8087	c.8058C>T	c.(8056-8058)TCC>TCT	p.S2686S	CSMD2_uc001bxm.1_Silent_p.S2684S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2686	Sushi 17.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGTGTATCCGGAATTGCAGG	0.582													7	28					0	0	0.001984	0	0
CSMD2	114784	broad.mit.edu	37	1	34166236	34166236	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:34166236C>T	uc001bxn.1	-	23	3523	c.3494G>A	c.(3493-3495)GGA>GAA	p.G1165E	CSMD2_uc001bxm.1_Missense_Mutation_p.G1205E|CSMD2_uc001bxo.1_Missense_Mutation_p.G78E	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1165	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCTAAAAACTCCCAGCAAACG	0.502													6	65					0	0	0.001168	0	0
CSMD2	114784	broad.mit.edu	37	1	34189802	34189802	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:34189802C>T	uc001bxn.1	-	19	2905	c.2876G>A	c.(2875-2877)GGC>GAC	p.G959D	CSMD2_uc001bxm.1_Missense_Mutation_p.G999D	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	959	Extracellular (Potential).|CUB 6.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTCACCCTTGCCATGAGATGT	0.527													10	67					0	0	0.006214	0	0
C1orf94	84970	broad.mit.edu	37	1	34677907	34677907	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:34677907C>T	uc001bxs.3	+	6	1450	c.1051C>T	c.(1051-1053)CCC>TCC	p.P351S	C1orf94_uc001bxt.2_Missense_Mutation_p.P541S	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	351							protein binding				0		Myeloproliferative disorder(586;0.0393)				GCCCAATTATCCCTACCCTCA	0.557													9	34					0	0	0.008291	0	0
C1orf94	84970	broad.mit.edu	37	1	34684324	34684324	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:34684324C>T	uc001bxs.3	+	7	1588	c.1189C>T	c.(1189-1191)CCC>TCC	p.P397S	C1orf94_uc001bxt.2_Missense_Mutation_p.P587S	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	397							protein binding				0		Myeloproliferative disorder(586;0.0393)				GATGCACAGCCCCTATTTTTC	0.493													13	53					0	0	0.003163	0	0
GJB3	2707	broad.mit.edu	37	1	35250940	35250940	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:35250940G>A	uc001bxx.2	+	2	1192	c.577G>A	c.(577-579)GGC>AGC	p.G193S	GJB3_uc001bxy.2_Missense_Mutation_p.G193S|GJB3_uc001bxz.3_Missense_Mutation_p.G193S|uc010ohs.1_RNA	NM_024009	NP_076872	O75712	CXB3_HUMAN	connexin 31	193	Helical; (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				CTTCATGGTGGGCGCCTCCGC	0.612													6	47					0	0	0.001168	0	0
TFAP2E	339488	broad.mit.edu	37	1	36054033	36054033	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:36054033C>T	uc010ohy.1	+	4	873	c.665C>T	c.(664-666)CCC>CTC	p.P222L	PSMB2_uc001bzd.1_Intron	NM_178548	NP_848643	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating	222						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				TGCTCCGTGCCCGGCCGGCTT	0.642													12	73					0	0	0.010729	0	0
MAP7D1	55700	broad.mit.edu	37	1	36644905	36644905	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:36644905T>C	uc001bzz.2	+	13	2389	c.2173T>C	c.(2173-2175)TCT>CCT	p.S725P	MAP7D1_uc001caa.2_Missense_Mutation_p.S693P|MAP7D1_uc001cab.2_Missense_Mutation_p.S688P|MAP7D1_uc001cac.2_Missense_Mutation_p.S425P|MAP7D1_uc001cad.2_Missense_Mutation_p.S262P	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	725						cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				GTCAGAAGTTTCTGAAACCAA	0.592													6	33					0	0	0.001168	0	0
INPP5B	3633	broad.mit.edu	37	1	38338742	38338742	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:38338742G>A	uc001ccg.1	-	19	2141	c.2047C>T	c.(2047-2049)CTG>TTG	p.L683L	INPP5B_uc009vvk.1_Silent_p.L624L|INPP5B_uc001ccf.1_Silent_p.L519L	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	763					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TCCAAGTGCAGAACCAGAATG	0.443													22	88					0	0	0.003330	0	0
INPP5B	3633	broad.mit.edu	37	1	38355352	38355352	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:38355352G>A	uc001ccg.1	-	9	768	c.674C>T	c.(673-675)TCC>TTC	p.S225F	INPP5B_uc009vvk.1_Missense_Mutation_p.S166F|INPP5B_uc001ccf.1_Missense_Mutation_p.S61F|INPP5B_uc010oij.1_RNA	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	305					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TGTGATAGTGGAGGAGCGAAC	0.393													17	82					0	0	0.008871	0	0
RHBDL2	54933	broad.mit.edu	37	1	39384781	39384781	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:39384781C>T	uc001ccu.1	-	2	332	c.104G>A	c.(103-105)GGA>GAA	p.G35E	RHBDL2_uc010oin.1_Missense_Mutation_p.G35E|RHBDL2_uc010oio.1_Missense_Mutation_p.G115E|RHBDL2_uc001ccv.2_Missense_Mutation_p.G35E	NM_017821	NP_060291	Q9NX52	RHBL2_HUMAN	rhomboid protease 2	35					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity				0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			ATCTTTACCTCCCCCATCCTC	0.483													10	99					0	0	0.006214	0	0
MACF1	23499	broad.mit.edu	37	1	39763387	39763387	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:39763387C>T	uc010ois.1	+	22	2671	c.2466C>T	c.(2464-2466)TCC>TCT	p.S822S	MACF1_uc001cda.1_Silent_p.S730S|MACF1_uc001cdc.1_5'Flank|MACF1_uc009vvq.1_5'Flank|MACF1_uc001cdb.1_5'Flank	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	822					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding	p.C822Y(1)		ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCAGCTTATCCCGCCTTGAAG	0.468													12	35					0	0	0.001855	0	0
MACF1	23499	broad.mit.edu	37	1	39798726	39798726	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:39798726C>T	uc010oiu.1	+	1	1917	c.1786C>T	c.(1786-1788)CCA>TCA	p.P596S	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2161					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGTTGAAACACCAAAGAAAGA	0.443													7	36					0	0	0.003080	0	0
MACF1	23499	broad.mit.edu	37	1	39812801	39812801	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:39812801G>A	uc010oiu.1	+	5	6185	c.6054G>A	c.(6052-6054)CAG>CAA	p.Q2018Q	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3583					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGTCCTTCCAGGACATTTTGG	0.512													13	54					0	0	0.003163	0	0
MACF1	23499	broad.mit.edu	37	1	39950307	39950307	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:39950307C>T	uc010oiu.1	+	63	17596	c.17465C>T	c.(17464-17466)CCA>CTA	p.P5822L	MACF1_uc010ois.1_Missense_Mutation_p.P5314L|MACF1_uc001cde.1_Missense_Mutation_p.P228L|MACF1_uc001cdf.1_Missense_Mutation_p.P197L|MACF1_uc001cdg.2_Missense_Mutation_p.P142L|MACF1_uc001cdh.2_Missense_Mutation_p.P105L	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	7272	Ser-rich.|C-terminal tail (By similarity).				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTGAAACGACCAACACCAACT	0.403													9	89					0	0	0.008291	0	0
RLF	6018	broad.mit.edu	37	1	40704629	40704629	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:40704629T>C	uc001cfc.3	+	8	4286	c.4255T>C	c.(4255-4257)TAT>CAT	p.Y1419H	RLF_uc001cfd.3_Missense_Mutation_p.Y1110H	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1419	C2H2-type 12.				chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TGCTGTTTTTTATACATTCAA	0.393													3	39					0	0	0.004672	0	0
ZNF684	127396	broad.mit.edu	37	1	41013040	41013040	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:41013040C>T	uc001cft.1	+	5	1296	c.1045C>T	c.(1045-1047)CAT>TAT	p.H349Y		NM_152373	NP_689586	Q5T5D7	ZN684_HUMAN	zinc finger protein 684	349	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			TCAGATAACTCATACAGGAGA	0.373													16	56					0	0	0.004007	0	0
KCNQ4	9132	broad.mit.edu	37	1	41300651	41300652	+	Silent	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:41300651_41300652CC>TT	uc001cgh.1	+	12	1708_1709	c.1626_1627CC>TT	c.(1624-1629)TTCCTG>TTTTTG	p.542_543FL>FL	KCNQ4_uc001cgi.1_Silent_p.488_489FL>FL	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	542_543	Cytoplasmic.				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TTCTCAAGTTCCTGGTGGCCAA	0.554													10	50					0	0	0.004672	0	0
HIVEP3	59269	broad.mit.edu	37	1	42049344	42049344	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:42049344G>A	uc001cgz.3	-	4	2338	c.1125C>T	c.(1123-1125)ATC>ATT	p.I375I	HIVEP3_uc001cha.3_Silent_p.I375I|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	375	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CCTGCTCATCGATCACCTTCT	0.562													11	60					0	0	0.010729	0	0
HIVEP3	59269	broad.mit.edu	37	1	42050174	42050174	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:42050174G>A	uc001cgz.3	-	4	1508	c.295C>T	c.(295-297)CCT>TCT	p.P99S	HIVEP3_uc001cha.3_Missense_Mutation_p.P99S|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	99					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGTGTCAGAGGGTGCTGCGGA	0.597													28	150					0	0	0.003271	0	0
PPCS	79717	broad.mit.edu	37	1	42922612	42922612	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:42922612C>T	uc001chl.2	+	1	440	c.376C>T	c.(376-378)CCG>TCG	p.P126S	ZMYND12_uc001chj.2_5'Flank|ZMYND12_uc010ojt.1_5'Flank|PPCS_uc001chk.2_Intron	NM_024664	NP_078940	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase isoform	126					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAATGCACTTCCGGGTTTTGC	0.622													5	81					0	0	0.000602	0	0
YBX1	4904	broad.mit.edu	37	1	43162381	43162382	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:43162381_43162382CC>TT	uc001chs.2	+	5	594_595	c.423_424CC>TT	c.(421-426)GACCGT>GATTGT	p.R142C		NM_004559	NP_004550	P67809	YBOX1_HUMAN	nuclease sensitive element binding protein 1	142					CRD-mediated mRNA stabilization|negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|positive regulation of cell division|transcription from RNA polymerase II promoter	CRD-mediated mRNA stability complex|extracellular region|histone pre-mRNA 3'end processing complex|nucleoplasm|stress granule|U12-type spliceosomal complex	double-stranded DNA binding|protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(4)|upper_aerodigestive_tract(1)	5	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATGCAGCAGACCGTAACCATTA	0.47													7	76					0	0	0.004672	0	0
TIE1	7075	broad.mit.edu	37	1	43777490	43777490	+	Silent	SNP	G	A	A	rs145245556		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:43777490G>A	uc001ciu.2	+	10	1561	c.1482G>A	c.(1480-1482)TCG>TCA	p.S494S	TIE1_uc010okd.1_Silent_p.S494S|TIE1_uc010oke.1_Silent_p.S449S|TIE1_uc009vwq.2_Silent_p.S450S|TIE1_uc010okf.1_Silent_p.S139S|TIE1_uc010okg.1_Silent_p.S139S	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	494	Extracellular (Potential).|Fibronectin type-III 1.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGGACTGGTCGACCATTGTGG	0.602													8	61					0	0	0.004482	0	0
PTPRF	5792	broad.mit.edu	37	1	44069127	44069127	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:44069127C>T	uc001cjr.2	+	15	2721	c.2381C>T	c.(2380-2382)TCC>TTC	p.S794F	PTPRF_uc001cjs.2_Missense_Mutation_p.S785F|PTPRF_uc001cju.2_Missense_Mutation_p.S365F|PTPRF_uc009vwt.2_Missense_Mutation_p.S356F|PTPRF_uc001cjv.2_Missense_Mutation_p.S254F|PTPRF_uc001cjw.2_Missense_Mutation_p.S20F	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	794	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACCACCTACTCCGTTACTGTT	0.582													10	50					0	0	0.008291	0	0
PTPRF	5792	broad.mit.edu	37	1	44072522	44072522	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:44072522T>G	uc001cjr.2	+	21	4080	c.3740T>G	c.(3739-3741)GTG>GGG	p.V1247G	PTPRF_uc001cjs.2_Missense_Mutation_p.V1238G|PTPRF_uc001cju.2_Missense_Mutation_p.V625G|PTPRF_uc009vwt.2_Missense_Mutation_p.V807G|PTPRF_uc001cjv.2_Missense_Mutation_p.V707G|PTPRF_uc001cjw.2_Missense_Mutation_p.V473G	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1247	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GATGAGATCGTGGTCCAGGTG	0.627													6	56					0	0	0.001168	0	0
B4GALT2	8704	broad.mit.edu	37	1	44451237	44451238	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:44451237_44451238CC>TT	uc001clg.2	+	6	1282_1283	c.912_913CC>TT	c.(910-915)GGCCGC>GGTTGC	p.R305C	B4GALT2_uc001clh.2_Missense_Mutation_p.R239C|B4GALT2_uc010okl.1_Missense_Mutation_p.R334C|B4GALT2_uc001cli.2_Missense_Mutation_p.R305C	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	305	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	TCCGAATCGGCCGCTACCGCAT	0.589													8	54					0	0	0.004672	0	0
KLF17	128209	broad.mit.edu	37	1	44595869	44595869	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:44595869G>A	uc001clp.2	+	2	983	c.925_splice	c.e2+1	p.G309_splice		NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393						regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					AAGCACACAGGTGAAGGAGGT	0.552													7	78					0	0	0.003080	0	0
RNF220	55182	broad.mit.edu	37	1	45092050	45092050	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:45092050C>T	uc001clv.1	+	5	1246	c.886C>T	c.(886-888)CAC>TAC	p.H296Y	RNF220_uc001clw.1_Missense_Mutation_p.H296Y|RNF220_uc010okx.1_Missense_Mutation_p.H57Y|RNF220_uc010oky.1_Missense_Mutation_p.H57Y	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	296					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CGATGACCTCCACCATTCAGA	0.562													4	45					0	0	0.009096	0	0
PLK3	1263	broad.mit.edu	37	1	45267365	45267365	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:45267365C>T	uc001cmn.2	+	4	607	c.507C>T	c.(505-507)ATC>ATT	p.I169I	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	169	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGCGGCAGATCCTTTCTGGCC	0.597													6	63					0	0	0.001168	0	0
PTCH2	8643	broad.mit.edu	37	1	45293110	45293110	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:45293110G>A	uc010olf.1	-	15	2347	c.2335C>T	c.(2335-2337)CGC>TGC	p.R779C	PTCH2_uc010olg.1_Missense_Mutation_p.R477C	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	779	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					AGCCAGGTGCGGGGTGCCTGG	0.662									Basal_Cell_Nevus_syndrome				5	33					0	0	0.001168	0	0
PTCH2	8643	broad.mit.edu	37	1	45293381	45293381	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:45293381G>A	uc010olf.1	-	15	2076	c.2064C>T	c.(2062-2064)ATC>ATT	p.I688I	PTCH2_uc010olg.1_Silent_p.I386I	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	688	Helical; (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					GCACCAGCACGATGGCCTGCG	0.647									Basal_Cell_Nevus_syndrome				6	32					0	0	0.004482	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47365943	47365943	+	RNA	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:47365943T>C	uc001cqo.1	-	1		c.205A>G			CYP4Z2P_uc009vyn.1_RNA	NR_002788				Homo sapiens cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to CYTOCHROME P450 4A1 (EC 1.14.15.3).												0						CTTGTGGCCATAGAACCAGTG	0.413													6	55					0	0	0.001168	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47366085	47366085	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:47366085C>T	uc001cqo.1	-	1		c.63G>A			CYP4Z2P_uc009vyn.1_RNA	NR_002788				Homo sapiens cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to CYTOCHROME P450 4A1 (EC 1.14.15.3).												0						GCCATGAGTTCCTGAAGCCAG	0.537													6	14					0	0	0.001168	0	0
CYP4A11	1579	broad.mit.edu	37	1	47403794	47403794	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:47403794C>T	uc001cqp.3	-	2	262	c.211G>A	c.(211-213)GAG>AAG	p.E71K	CYP4A11_uc001cqq.2_Missense_Mutation_p.E71K|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	71					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	CGTTGTAGCTCCTGGTCCTGT	0.502													6	77					0	0	0.001984	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610048	47610048	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:47610048G>A	uc001cqv.1	+	7	861	c.810G>A	c.(808-810)AGG>AGA	p.R270R	CYP4A22_uc009vyo.2_Silent_p.R270R|CYP4A22_uc009vyp.2_Missense_Mutation_p.E219K	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	270						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						TCCAACTGAGGAAGGCTCAAC	0.542													23	68					0	0	0.014323	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610589	47610589	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:47610589G>A	uc001cqv.1	+	9	1220	c.1169G>A	c.(1168-1170)GGA>GAA	p.G390E	CYP4A22_uc009vyo.2_Missense_Mutation_p.G390E|CYP4A22_uc009vyp.2_Missense_Mutation_p.G292E	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	390						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						CCAGGCATTGGAAGAGAGCTC	0.572													9	44					0	0	0.006214	0	0
ELAVL4	1996	broad.mit.edu	37	1	50661331	50661331	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:50661331G>A	uc001csb.2	+	5	875	c.607G>A	c.(607-609)GAA>AAA	p.E203K	ELAVL4_uc001cry.3_Missense_Mutation_p.E206K|ELAVL4_uc001crz.3_Missense_Mutation_p.E203K|ELAVL4_uc001csa.3_Missense_Mutation_p.E220K|ELAVL4_uc001csc.3_Missense_Mutation_p.E203K|ELAVL4_uc009vyu.2_Missense_Mutation_p.E208K|ELAVL4_uc010omz.1_Missense_Mutation_p.E208K	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	203	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						CGGTGCTACGGAACCGATTAC	0.582													7	68					0	0	0.001984	0	0
LRP8	7804	broad.mit.edu	37	1	53726199	53726199	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:53726199G>A	uc001cvi.1	-	13	2135	c.1993C>T	c.(1993-1995)CTG>TTG	p.L665L	LRP8_uc001cvh.1_Silent_p.L218L|LRP8_uc001cvk.1_Silent_p.L495L|LRP8_uc001cvj.1_Silent_p.L665L|LRP8_uc001cvl.1_Silent_p.L536L|LRP8_uc001cvm.1_Silent_p.L250L	NM_004631	NP_004622	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein	665	LDL-receptor class B 5.|Extracellular (Potential).				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0						TTCTCAGCCAGGATGGAGATT	0.532													6	85					0	0	0.003080	0	0
CDCP2	200008	broad.mit.edu	37	1	54610311	54610311	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:54610311G>A	uc001cwv.1	-	2	1103	c.255C>T	c.(253-255)TTC>TTT	p.F85F		NM_201546	NP_963840	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2 precursor	85	CUB 1.					extracellular region				ovary(1)	1						CCAGAAAGTCGAAGCTGCAGG	0.612													9	26					0	0	0.008291	0	0
FAM151A	338094	broad.mit.edu	37	1	55088965	55088965	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:55088965G>A	uc001cxn.2	-	1	236	c.104C>T	c.(103-105)ACC>ATC	p.T35I	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	35						integral to membrane					0						CCGCCGCAGGGTGATGGCAAG	0.562													8	50					0	0	0.003080	0	0
PARS2	25973	broad.mit.edu	37	1	55224553	55224553	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:55224553G>A	uc001cxy.2	-	2	365	c.282C>T	c.(280-282)ACC>ACT	p.T94T		NM_152268	NP_689481	Q7L3T8	SYPM_HUMAN	prolyl-tRNA synthetase (mitochondrial)(putative)	94					prolyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|proline-tRNA ligase activity			ovary(2)	2					L-Proline(DB00172)	TGGCACGGACGGTATATGGCA	0.443													9	37					0	0	0.006214	0	0
BSND	7809	broad.mit.edu	37	1	55464876	55464876	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:55464876C>T	uc001cye.2	+	1	260	c.17C>T	c.(16-18)ACC>ATC	p.T6I		NM_057176	NP_476517	Q8WZ55	BSND_HUMAN	barttin	6	Helical; (Potential).					basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				ovary(1)|skin(1)	2						GACGAGAAGACCTTCCGGATC	0.617													6	80					0	0	0.003080	0	0
PCSK9	255738	broad.mit.edu	37	1	55521729	55521730	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:55521729_55521730CC>TT	uc001cyf.1	+	6	1154_1155	c.863_864CC>TT	c.(862-864)CCC>CTT	p.P288L	PCSK9_uc010oom.1_RNA	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	288	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GTGCTGCTGCCCCTGGCGGGTG	0.673													14	172					0	0	0.004672	0	0
C1orf168	199920	broad.mit.edu	37	1	57202773	57202773	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:57202773C>T	uc001cym.3	-	15	2186	c.1780G>A	c.(1780-1782)GAA>AAA	p.E594K	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	594										ovary(3)|skin(2)	5						GACTCTTTTTCACTCAGGTCT	0.328													4	32					0	0	0.001168	0	0
C8B	732	broad.mit.edu	37	1	57417813	57417813	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:57417813C>T	uc001cyp.2	-	5	641	c.574G>A	c.(574-576)GAT>AAT	p.D192N	C8B_uc010oon.1_Missense_Mutation_p.D130N|C8B_uc010ooo.1_Missense_Mutation_p.D140N	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	192	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TACCTGTGATCAAGAACTGGG	0.448													17	101					0	0	0.004990	0	0
C1orf87	127795	broad.mit.edu	37	1	60538282	60538282	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:60538282C>T	uc001czs.1	-	2	126	c.34G>A	c.(34-36)GAT>AAT	p.D12N		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	12							calcium ion binding			ovary(1)|breast(1)	2						GGCATTGCATCTGATCCACGG	0.393													7	77					0	0	0.004482	0	0
KANK4	163782	broad.mit.edu	37	1	62739545	62739545	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:62739545C>T	uc001dah.3	-	3	1608	c.1231G>A	c.(1231-1233)GAC>AAC	p.D411N	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	411										ovary(3)|skin(2)|lung(1)	6						ACCATCACGTCCGTCTGGCCC	0.517													14	101					0	0	0.001855	0	0
EFCAB7	84455	broad.mit.edu	37	1	64038177	64038177	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:64038177T>C	uc001dbf.2	+	14	2174	c.1880T>C	c.(1879-1881)CTT>CCT	p.L627P		NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	627							calcium ion binding				0						ATATATTCTCTTATTTCTTAA	0.254													3	12					0	0	0.009096	0	0
ROR1	4919	broad.mit.edu	37	1	64474976	64474976	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:64474976G>A	uc001dbj.2	+	2	491	c.92_splice	c.e2-1	p.E31_splice	ROR1_uc001dbi.3_Splice_Site_p.E31_splice	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1						transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						TTTCTTTTCAGAAACAGAGCT	0.438													9	166					0	0	0.004482	0	0
JAK1	3716	broad.mit.edu	37	1	65332753	65332753	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:65332753G>A	uc001dbu.1	-	7	1035	c.786C>T	c.(784-786)TCC>TCT	p.S262S	JAK1_uc009wam.1_Silent_p.S250S	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	262	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		GGTCATGCGTGGACACGCTGC	0.403			Mis		ALL								22	88					0	0	0.002780	0	0
DIRAS3	9077	broad.mit.edu	37	1	68512782	68512782	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:68512782G>A	uc001ded.2	-	2	494	c.199C>T	c.(199-201)CTG>TTG	p.L67L	uc001deb.1_Intron|uc001dec.1_Intron	NM_004675	NP_004666	O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	67	Effector region (Potential).				regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						ATGGTCGGCAGGTACTCATGA	0.592													10	76					0	0	0.010729	0	0
RPE65	6121	broad.mit.edu	37	1	68910347	68910347	+	Missense_Mutation	SNP	G	A	A	rs121918844		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:68910347G>A	uc001dei.1	-	5	416	c.362C>T	c.(361-363)TCT>TTT	p.S121F		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	121					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						TCGAAAGTAAGAAAAAAACCT	0.368													5	31					0	0	0.001168	0	0
ANKRD13C	81573	broad.mit.edu	37	1	70740419	70740419	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:70740419G>A	uc001dex.3	-	11	1704	c.1378C>T	c.(1378-1380)CCC>TCC	p.P460S	ANKRD13C_uc009wbk.2_Missense_Mutation_p.P425S	NM_030816	NP_110443	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	460					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding				0						ATCCCTAAGGGAAATTCCTGG	0.383													10	141					0	0	0.010729	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74492607	74492607	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:74492607C>T	uc001dfy.3	-	8	1957	c.1765G>A	c.(1765-1767)GAT>AAT	p.D589N	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	589	Potential.									ovary(2)	2						GCAATCATATCCATAACAAAT	0.294													4	28					0	0	0.001168	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507480	74507480	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:74507480G>A	uc001dfy.3	-	7	1327	c.1135C>T	c.(1135-1137)CCT>TCT	p.P379S	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	379										ovary(2)	2						GGATATGCAGGAAAAAAATGT	0.353													11	55					0	0	0.001855	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74648365	74648365	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:74648365G>A	uc001dfy.3	-	3	622	c.430C>T	c.(430-432)CTT>TTT	p.L144F	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	144	LRRCT.									ovary(2)	2						CTGTTAACAAGAACATGTCTA	0.368													5	44					0	0	0.000602	0	0
C1orf173	127254	broad.mit.edu	37	1	75038412	75038412	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:75038412C>T	uc001dgg.2	-	14	3201	c.2982G>A	c.(2980-2982)TTG>TTA	p.L994L		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	994	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TGAAGGGGCTCAAGCGTGTTT	0.532													11	44					0	0	0.008291	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77510236	77510236	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:77510236G>A	uc001dhi.2	+	3	784	c.609G>A	c.(607-609)ATG>ATA	p.M203I	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	203	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						AGGCCTTCATGATTACTCGCC	0.582													24	94					0	0	0.006320	0	0
PTGFR	5737	broad.mit.edu	37	1	78958515	78958515	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:78958515C>T	uc001din.2	+	2	353	c.87C>T	c.(85-87)TCC>TCT	p.S29S	PTGFR_uc001dim.2_Silent_p.S29S	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	29	Extracellular (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity	p.S29F(1)		ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	ACCGGCTTTCCGTATTTTTTT	0.438													6	73					0	0	0.001984	0	0
PTGFR	5737	broad.mit.edu	37	1	79002142	79002142	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:79002142G>A	uc001din.2	+	3	1116	c.850G>A	c.(850-852)GAA>AAA	p.E284K	PTGFR_uc001dim.2_3'UTR	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	284	Extracellular (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GGAAACCTGTGAAACAACACT	0.373													11	53					0	0	0.010729	0	0
ELTD1	64123	broad.mit.edu	37	1	79358832	79358832	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:79358832G>A	uc001diq.3	-	13	1948	c.1792C>T	c.(1792-1794)CGT>TGT	p.R598C		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	598	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GCAGTGTGACGAAAAACTTTG	0.299													5	37					0	0	0.001984	0	0
LPHN2	23266	broad.mit.edu	37	1	82408790	82408790	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:82408790C>T	uc001dit.3	+	6	716	c.535C>T	c.(535-537)CGT>TGT	p.R179C	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.R179C|LPHN2_uc001div.2_Missense_Mutation_p.R179C|LPHN2_uc009wcd.2_Missense_Mutation_p.R179C	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	179	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GACTCCCTATCGTACCGATAC	0.398													13	52					0	0	0.003163	0	0
LPHN2	23266	broad.mit.edu	37	1	82408945	82408945	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:82408945G>A	uc001dit.3	+	6	871	c.690G>A	c.(688-690)GTG>GTA	p.V230V	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.V230V|LPHN2_uc001div.2_Silent_p.V230V|LPHN2_uc009wcd.2_Silent_p.V230V	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	230	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GGAATATTGTGAAATTTGACT	0.383													7	38					0	0	0.003080	0	0
LPHN2	23266	broad.mit.edu	37	1	82431755	82431755	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:82431755C>T	uc001dit.3	+	11	2161	c.1980C>T	c.(1978-1980)GCC>GCT	p.A660A	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.A660A|LPHN2_uc001div.2_Silent_p.A660A|LPHN2_uc009wcd.2_Silent_p.A660A|LPHN2_uc001diw.2_Silent_p.A244A	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	673	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TGGAAGTTGCCGTACTCAGTA	0.433													8	83					0	0	0.003080	0	0
MCOLN2	255231	broad.mit.edu	37	1	85405368	85405368	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:85405368G>A	uc001dkm.2	-	9	1219	c.978C>T	c.(976-978)TTC>TTT	p.F326F	MCOLN2_uc001dkn.2_Intron	NM_153259	NP_694991	Q8IZK6	MCLN2_HUMAN	mucolipin 2	326						integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		ACTTCTCCAGGAAGAAATTTA	0.453													4	42					0	0	0.001168	0	0
CLCA4	22802	broad.mit.edu	37	1	87045120	87045120	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:87045120G>A	uc009wcs.2	+	13	2250	c.2206G>A	c.(2206-2208)GGA>AGA	p.G736R	CLCA4_uc009wct.2_Missense_Mutation_p.G499R|CLCA4_uc009wcu.2_Missense_Mutation_p.G556R	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	736						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AACAGCATCCGGAGGTGCATT	0.478													14	56					0	0	0.003163	0	0
GBP1	2633	broad.mit.edu	37	1	89528828	89528828	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:89528828G>A	uc001dmx.2	-	2	310	c.90C>T	c.(88-90)ATC>ATT	p.I30I		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	30					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TGGCAGAAAGGATCTTCAGAG	0.512													17	79					0	0	0.004990	0	0
GBP6	163351	broad.mit.edu	37	1	89845982	89845982	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:89845982G>A	uc001dnf.2	+	6	937	c.663G>A	c.(661-663)AGG>AGA	p.R221R	GBP6_uc010ost.1_Silent_p.R91R	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	221							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		ATTTTCCCAGGGAGTGCATCA	0.408													15	45					0	0	0.004007	0	0
HFM1	164045	broad.mit.edu	37	1	91727940	91727940	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:91727940G>A	uc001doa.3	-	38	4196	c.4096C>T	c.(4096-4098)CAA>TAA	p.Q1366*	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Nonsense_Mutation_p.Q1045*|HFM1_uc001dob.3_Nonsense_Mutation_p.Q554*	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1366							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TTTCTTTCTTGAAAATGGACC	0.294													14	101					0	0	0.007413	0	0
EVI5	7813	broad.mit.edu	37	1	93101794	93101794	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:93101794T>G	uc001dox.2	-	12	1454	c.1444A>C	c.(1444-1446)AAA>CAA	p.K482Q	EVI5_uc010otf.1_Missense_Mutation_p.K493Q|EVI5_uc001doy.1_RNA	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	482	Dimerization.|Targeting to the centrosomes.|Potential.|Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		TGCATCTCTTTTAATGCACAC	0.398													8	97					0	0	0.004482	0	0
ABCA4	24	broad.mit.edu	37	1	94471041	94471042	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:94471041_94471042GG>AA	uc001dqh.2	-	44	6206_6207	c.6102_6103CC>TT	c.(6100-6105)TACCTT>TATTTT	p.L2035F	ABCA4_uc001dqi.1_Missense_Mutation_p.L154F	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	2035	ABC transporter 2.|Cytoplasmic.		L -> P (in STGD1).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CGGGCATAAAGGTAAAGATGTT	0.416													6	77					0	0	0.004672	0	0
ABCA4	24	broad.mit.edu	37	1	94476400	94476401	+	Missense_Mutation	DNP	GA	AC	AC	rs61750635		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:94476400_94476401GA>AC	uc001dqh.2	-	40	5773_5774	c.5669_5670TC>GT	c.(5668-5670)TTC>TGT	p.F1890C	ABCA4_uc001dqi.1_Missense_Mutation_p.F9C|ABCA4_uc009wdp.1_Missense_Mutation_p.F158C	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1890	Helical; (Potential).		Missing (in STGD1).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GGGTCAGGAGGAAGTACACCAC	0.589													4	32					0	0	0.004672	0	0
ABCA4	24	broad.mit.edu	37	1	94487458	94487458	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:94487458C>T	uc001dqh.2	-	33	4821	c.4717G>A	c.(4717-4719)GGG>AGG	p.G1573R		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1573	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AGTGCTTCCCCCGTGATGGGG	0.498													5	52					0	0	0.001984	0	0
ABCA4	24	broad.mit.edu	37	1	94512566	94512566	+	Missense_Mutation	SNP	G	A	A	rs61749446		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:94512566G>A	uc001dqh.2	-	19	2931	c.2827C>T	c.(2827-2829)CGG>TGG	p.R943W	ABCA4_uc010otn.1_Missense_Mutation_p.R869W	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	943	Cytoplasmic.|ABC transporter 1.		R -> W (in STGD1 and FFM).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		ACAGCTGGCCGGCCACAGGGC	0.512													12	171					0	0	0.010729	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94685905	94685905	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:94685905G>A	uc001dqj.3	-	3	618	c.249C>T	c.(247-249)CTC>CTT	p.L83L	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Silent_p.L83L	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	83					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTAAAACACGGAGCAGTTCCT	0.308													11	38					0	0	0.008291	0	0
DPYD	1806	broad.mit.edu	37	1	97544576	97544576	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:97544576C>T	uc001drv.2	-	23	3171	c.3034G>A	c.(3034-3036)GAA>AAA	p.E1012K		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	1012					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CTCTTTGGTTCATAAGGTGTT	0.453													18	94					0	0	0.010504	0	0
PALMD	54873	broad.mit.edu	37	1	100152287	100152287	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:100152287G>A	uc001dsg.2	+	4	750	c.307G>A	c.(307-309)GAA>AAA	p.E103K	PALMD_uc001dsf.2_Missense_Mutation_p.E103K	NM_017734	NP_060204	Q9NP74	PALMD_HUMAN	palmdelphin	103	Potential.				regulation of cell shape	cytoplasm|membrane				ovary(2)|pancreas(1)	3		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		CTCAACGAAGGAAGAGGCCAT	0.338													11	126					0	0	0.010729	0	0
FRRS1	391059	broad.mit.edu	37	1	100206365	100206365	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:100206365G>A	uc001dsh.1	-	6	1162	c.560C>T	c.(559-561)TCC>TTC	p.S187F		NM_001013660	NP_001013682	Q6ZNA5	FRRS1_HUMAN	stromal cell derived factor receptor 2 homolog	187					electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		GGTTAAGTGGGAAACGGGAGG	0.259													8	96					0	0	0.008291	0	0
AGL	178	broad.mit.edu	37	1	100346653	100346653	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:100346653C>T	uc001dsi.1	+	15	2321	c.1921C>T	c.(1921-1923)CTT>TTT	p.L641F	AGL_uc001dsj.1_Missense_Mutation_p.L641F|AGL_uc001dsk.1_Missense_Mutation_p.L641F|AGL_uc001dsl.1_Missense_Mutation_p.L641F|AGL_uc001dsm.1_Missense_Mutation_p.L625F|AGL_uc001dsn.1_Missense_Mutation_p.L624F	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	641	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GTATGATGCTCTTCCAAGTAC	0.353													9	42					0	0	0.010729	0	0
AMY2B	280	broad.mit.edu	37	1	104121994	104121994	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:104121994G>A	uc001duq.2	+	12	2024	c.1408G>A	c.(1408-1410)GGA>AGA	p.G470R	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.G470R|AMY2B_uc001dus.1_Intron	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	470					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TGTCATTTCTGGAGATAAAAT	0.343													26	447					0	0	0.003271	0	0
AKNAD1	254268	broad.mit.edu	37	1	109380268	109380268	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:109380268C>T	uc001dwa.2	-	7	1709	c.1440G>A	c.(1438-1440)ATG>ATA	p.M480I	AKNAD1_uc010ovb.1_Missense_Mutation_p.M187I|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	480	Potential.									ovary(3)	3						TGCTTTCATCCATTTTCTCTT	0.413													12	63					0	0	0.010729	0	0
GPSM2	29899	broad.mit.edu	37	1	109428193	109428193	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:109428193C>T	uc010ovc.1	+	2	545	c.49C>T	c.(49-51)CGT>TGT	p.R17C	AKNAD1_uc010ovb.1_Intron|GPSM2_uc010ovd.1_Missense_Mutation_p.R17C|GPSM2_uc010ove.1_Missense_Mutation_p.R17C	NM_013296	NP_037428	P81274	GPSM2_HUMAN	LGN protein	17					G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		TTTTCATGTTCGTTACAGGTA	0.294													40	398					0	0	0.014410	0	0
CELSR2	1952	broad.mit.edu	37	1	109794276	109794276	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:109794276C>T	uc001dxa.3	+	1	1636	c.1575C>T	c.(1573-1575)CTC>CTT	p.L525L		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	525	Cadherin 4.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		ACCTGGTTCTCCATGTCCAGG	0.562													63	280					0	0	0.014410	0	0
EPS8L3	79574	broad.mit.edu	37	1	110301246	110301246	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:110301246C>T	uc001dyr.1	-	7	646	c.501G>A	c.(499-501)TGG>TGA	p.W167*	EPS8L3_uc001dys.1_Nonsense_Mutation_p.W167*|EPS8L3_uc001dyq.1_Nonsense_Mutation_p.W168*|EPS8L3_uc009wfm.1_Nonsense_Mutation_p.W134*|EPS8L3_uc009wfn.1_Nonsense_Mutation_p.W134*|EPS8L3_uc009wfo.1_Nonsense_Mutation_p.W114*	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	167						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		CAGGCCCCCTCCATCTGTCCT	0.617													9	38					0	0	0.006214	0	0
KCNA10	3744	broad.mit.edu	37	1	111060470	111060470	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:111060470G>A	uc001dzt.1	-	1	1328	c.940C>T	c.(940-942)CCC>TCC	p.P314S		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	314	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GCAAAGTAGGGGATAATGGAG	0.532													13	70					0	0	0.001855	0	0
C1orf103	55791	broad.mit.edu	37	1	111490995	111490995	+	Silent	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:111490995T>A	uc001eaa.2	-	4	2152	c.1896A>T	c.(1894-1896)GCA>GCT	p.A632A	C1orf103_uc001dzz.2_Silent_p.A96A|C1orf103_uc001eab.2_Silent_p.A96A|C1orf103_uc001eac.1_Silent_p.A95A	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		TATTAGTTTTTGCTTTTCTTT	0.343													5	19					0	0	0.000602	0	0
HIPK1	204851	broad.mit.edu	37	1	114499826	114499826	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:114499826C>T	uc001eem.2	+	7	1834	c.1673C>T	c.(1672-1674)CCC>CTC	p.P558L	HIPK1_uc001eel.2_Missense_Mutation_p.P558L|HIPK1_uc001een.2_Missense_Mutation_p.P558L|HIPK1_uc001eeo.2_Missense_Mutation_p.P184L|HIPK1_uc001eep.2_Missense_Mutation_p.P164L	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCAAGAGTCCCTTCACTACA	0.388													8	29					0	0	0.003080	0	0
AMPD1	270	broad.mit.edu	37	1	115238086	115238086	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:115238086G>A	uc001efe.1	-	1	91	c.7C>T	c.(7-9)CTG>TTG	p.L3L	AMPD1_uc001eff.1_Silent_p.L3L	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	3					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	AGTTTGAACAGAGGCATTGTT	0.398													12	150					0	0	0.002450	0	0
SYCP1	6847	broad.mit.edu	37	1	115454199	115454199	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:115454199G>A	uc001efr.2	+	18	1734	c.1525G>A	c.(1525-1527)GAG>AAG	p.E509K	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.E509K|SYCP1_uc009wgw.2_Missense_Mutation_p.E509K	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	509	Potential.			IQLTAITTSEQYYSKEVKDLKTELENEK -> YSYCHYHKW TVLPKRGQRPKLSSKRE (in Ref. 2; BAA22586).	cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTTGAAAACGAGAAGTATGT	0.244													4	11					0	0	0.009096	0	0
TSPAN2	10100	broad.mit.edu	37	1	115600175	115600175	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:115600175C>T	uc001eft.2	-	6	561	c.499G>A	c.(499-501)GAG>AAG	p.E167K		NM_005725	NP_005716	O60636	TSN2_HUMAN	tetraspan 2	167	Extracellular (Potential).					integral to membrane					0	Lung SC(450;0.211)	all_cancers(81;2.9e-07)|all_epithelial(167;1.42e-06)|all_lung(203;6.72e-06)|Lung NSC(69;1.13e-05)|Acute lymphoblastic leukemia(138;0.191)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		CCTAGAAGCTCCTTTGGGCAT	0.483													15	211					0	0	0.004007	0	0
IGSF3	3321	broad.mit.edu	37	1	117156498	117156498	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:117156498G>A	uc001egr.1	-	4	1426	c.721C>T	c.(721-723)CAG>TAG	p.Q241*	IGSF3_uc001egq.1_Nonsense_Mutation_p.Q241*	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	241	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		AATTCGCCCTGGTCAGAAGGC	0.627													5	29					0	0	0.000602	0	0
CD2	914	broad.mit.edu	37	1	117311214	117311214	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:117311214C>T	uc001egu.3	+	5	894	c.865C>T	c.(865-867)CGT>TGT	p.R289C		NM_001767	NP_001758	P06729	CD2_HUMAN	CD2 molecule precursor	289	Cytoplasmic (Potential).|Pro-rich.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			breast(1)	1	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	ACCTGGTCATCGTTCCCAGGC	0.587													6	33					0	0	0.001984	0	0
CD101	9398	broad.mit.edu	37	1	117552638	117552638	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:117552638C>T	uc010oxb.1	+	2	268	c.210C>T	c.(208-210)GTC>GTT	p.V70V	CD101_uc009whd.2_Silent_p.V70V|CD101_uc010oxc.1_Silent_p.V70V|CD101_uc010oxd.1_Silent_p.V70V	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	70	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CCCAGGAAGTCCAGATCATTA	0.557													4	53					0	0	0.009096	0	0
WDR3	10885	broad.mit.edu	37	1	118485129	118485129	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:118485129C>T	uc010oxe.1	+	10	1125	c.1059C>T	c.(1057-1059)ATC>ATT	p.I353I	WDR3_uc001ehi.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	353						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		AAGATGAAATCCAGCGGGTGA	0.343													4	73					0	0	0.009096	0	0
WDR3	10885	broad.mit.edu	37	1	118499763	118499763	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:118499763C>T	uc010oxe.1	+	25	2592	c.2526C>T	c.(2524-2526)TTC>TTT	p.F842F	WDR3_uc001ehi.2_Intron|SPAG17_uc001ehk.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	842						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TTAACGAATTCATTCAGCTGG	0.378													22	88					0	0	0.014323	0	0
TBX15	6913	broad.mit.edu	37	1	119427931	119427931	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:119427931C>T	uc001ehl.1	-	8	1230	c.915G>A	c.(913-915)CAG>CAA	p.Q305Q	TBX15_uc009whj.1_Silent_p.Q129Q	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	411						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CTGGGTAGCTCTGCAAGGCAG	0.542													4	30					0	0	0.009096	0	0
HMGCS2	3158	broad.mit.edu	37	1	120301832	120301832	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:120301832C>T	uc001eid.2	-	4	810	c.759G>A	c.(757-759)GTG>GTA	p.V253V	HMGCS2_uc010oxj.1_Silent_p.V211V|HMGCS2_uc001eie.2_Silent_p.V161V	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	253					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		GCTTCCCATCCACTATTGGGT	0.458													47	379					0	0	0.014410	0	0
HMGCS2	3158	broad.mit.edu	37	1	120307109	120307109	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:120307109C>T	uc001eid.2	-	2	296	c.245G>A	c.(244-246)GGA>GAA	p.G82E	HMGCS2_uc010oxj.1_Missense_Mutation_p.G82E|HMGCS2_uc001eie.2_5'UTR	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	82					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		TGTATACTTTCCTGCTTCCAC	0.552													42	407					0	0	0.009718	0	0
NBPF7	343505	broad.mit.edu	37	1	120384086	120384086	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:120384086G>A	uc010oxk.1	-	3	1097	c.476C>T	c.(475-477)TCC>TTC	p.S159F		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	159						cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		CTGCCCCTGGGAGTTGTCATG	0.577													68	293					0	0	0.014410	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144865929	144865929	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:144865929C>T	uc001elw.3	-	35	5942	c.5651G>A	c.(5650-5652)GGA>GAA	p.G1884E	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.G1778E|PDE4DIP_uc001elv.3_Missense_Mutation_p.G891E|PDE4DIP_uc001ema.2_Missense_Mutation_p.G71E	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1884	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGAAGTGGATCCTGTCCCAGA	0.468			T	PDGFRB	MPD								24	424					0	0	0.005443	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144879386	144879386	+	Missense_Mutation	SNP	C	T	T	rs151134727	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:144879386C>T	uc001elw.3	-	27	4355	c.4064G>A	c.(4063-4065)CGA>CAA	p.R1355Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.R1311Q|PDE4DIP_uc001elv.3_Missense_Mutation_p.R362Q	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1355	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GATGTCCTTTCGTAGGACCAA	0.493			T	PDGFRB	MPD								19	339					0	0	0.010504	0	0
NBPF10	100132406	broad.mit.edu	37	1	145301742	145301742	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:145301742C>T	uc001end.3	+	7	1046	c.1011C>T	c.(1009-1011)CTC>CTT	p.L337L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Silent_p.L337L|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Silent_p.L66L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	337											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCAAAGACCTCATAAAATTTA	0.522													38	312					0	0	0.014410	0	0
HFE2	148738	broad.mit.edu	37	1	145416641	145416641	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:145416641G>A	uc001eni.2	+	4	1311	c.986G>A	c.(985-987)CGA>CAA	p.R329Q	NBPF10_uc001emp.3_Intron|HFE2_uc001enj.2_Missense_Mutation_p.R103Q|HFE2_uc001enk.2_Missense_Mutation_p.R216Q|HFE2_uc001enl.2_Missense_Mutation_p.R103Q	NM_213653	NP_998818	Q6ZVN8	RGMC_HUMAN	hemojuvelin isoform a precursor	329					axon guidance	anchored to membrane				ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGACTCTCTCGATCAGAGCGC	0.552													6	50					0	0	0.001168	0	0
ITGA10	8515	broad.mit.edu	37	1	145535801	145535801	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:145535801G>A	uc001eoa.2	+	16	2065	c.1989G>A	c.(1987-1989)CAG>CAA	p.Q663Q	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Silent_p.Q532Q|ITGA10_uc009wiw.2_Silent_p.Q520Q|ITGA10_uc010oyw.1_Silent_p.Q608Q	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	663	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GTGTGGTTCAGAGGGACTGTA	0.567													6	72					0	0	0.001984	0	0
ANKRD35	148741	broad.mit.edu	37	1	145561707	145561707	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:145561707G>T	uc001eob.1	+	10	1503	c.1395G>T	c.(1393-1395)AAG>AAT	p.K465N	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.K308N	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	465										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTGGTCAGAAGGAGAGTTCCC	0.567													8	72					1.06961e-07	1.15742e-07	0.003080	1	0
PIAS3	10401	broad.mit.edu	37	1	145585607	145585607	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:145585607C>T	uc001eoc.1	+	14	1963	c.1872C>T	c.(1870-1872)ATC>ATT	p.I624I	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_Silent_p.I293I	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	624					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGTCAGACATCATTTCCCTGG	0.597													29	101					0	0	0.013726	0	0
BCL9	607	broad.mit.edu	37	1	147092820	147092820	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:147092820C>T	uc001epq.2	+	8	3599	c.2859C>T	c.(2857-2859)CCC>CCT	p.P953P	BCL9_uc010ozr.1_Silent_p.P879P	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	953	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					ATAAAGCACCCCTCACCATGG	0.547			T	IGH@|IGL@	B-ALL								9	44					0	0	0.004482	0	0
GJA5	2702	broad.mit.edu	37	1	147230527	147230527	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:147230527C>T	uc001eps.1	-	2	961	c.820G>A	c.(820-822)GGC>AGC	p.G274S	GJA5_uc001ept.1_Missense_Mutation_p.G274S	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	274	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CCCCCAGGGCCATTCTCCAGG	0.552													22	68					0	0	0.003330	0	0
Unknown	0	broad.mit.edu	37	1	148882285	148882285	+	RNA	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:148882285G>C	uc009wkv.1	+	4		c.314G>C								Homo sapiens cDNA, FLJ17483.																		GGAGCAGAAGGAAGATTACTT	0.358													5	165					0	0	0.001168	0	0
MTMR11	10903	broad.mit.edu	37	1	149905553	149905553	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:149905553G>A	uc001etl.3	-	9	1061	c.810C>T	c.(808-810)CTC>CTT	p.L270L	MTMR11_uc001etm.1_Silent_p.L198L|MTMR11_uc010pbm.1_Silent_p.L242L|MTMR11_uc010pbn.1_Silent_p.L112L	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	270	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CTCCACAGCGGAGAAGATCAC	0.552													9	31					0	0	0.006214	0	0
C1orf51	148523	broad.mit.edu	37	1	150256268	150256268	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:150256268G>A	uc001euh.2	+	3	556	c.420G>A	c.(418-420)CTG>CTA	p.L140L	C1orf51_uc001eui.2_Silent_p.L52L|C1orf51_uc001euj.2_Silent_p.L140L	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	140											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCAATGGGCTGAAGATGGGTC	0.403													8	50					0	0	0.006214	0	0
RPRD2	23248	broad.mit.edu	37	1	150445226	150445226	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:150445226C>T	uc009wlr.2	+	11	4003	c.3802C>T	c.(3802-3804)CCT>TCT	p.P1268S	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Missense_Mutation_p.P1242S	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1268	Pro-rich.						protein binding			ovary(1)	1						AATTCCTTTCCCTACCCCACC	0.612													7	68					0	0	0.003080	0	0
TARS2	80222	broad.mit.edu	37	1	150469306	150469306	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:150469306C>T	uc001euq.2	+	9	949	c.942C>T	c.(940-942)TTC>TTT	p.F314F	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Intron|TARS2_uc009wlt.2_Intron|TARS2_uc009wls.2_Intron	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	314					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	TCTTCTTCTTCCATGAACTGA	0.537													8	39					0	0	0.008291	0	0
ECM1	1893	broad.mit.edu	37	1	150483433	150483434	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:150483433_150483434CC>TT	uc001eus.2	+	6	666_667	c.467_468CC>TT	c.(466-468)TCC>TTT	p.S156F	ECM1_uc010pce.1_Missense_Mutation_p.S85F|ECM1_uc010pcf.1_Missense_Mutation_p.S78F|ECM1_uc001eut.2_Missense_Mutation_p.S156F|ECM1_uc001euu.2_Missense_Mutation_p.S185F|ECM1_uc001euv.2_Missense_Mutation_p.S183F|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	156	2 X approximate repeats.|1.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CAGGACCGGTCCCAAGGGGGCT	0.599													17	138					0	0	0.004672	0	0
GOLPH3L	55204	broad.mit.edu	37	1	150621176	150621176	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:150621176C>T	uc001evj.2	-	5	696	c.479G>A	c.(478-480)CGA>CAA	p.R160Q	GOLPH3L_uc010pci.1_Missense_Mutation_p.R116Q	NM_018178	NP_060648	Q9H4A5	GLP3L_HUMAN	Golgi phosphoprotein 3-like	160						Golgi cisterna membrane				ovary(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			GATGCGCTCTCGTACATTTCT	0.398													5	62					0	0	0.001168	0	0
SETDB1	9869	broad.mit.edu	37	1	150913808	150913808	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:150913808C>T	uc001evu.2	+	5	641	c.451C>T	c.(451-453)CGT>TGT	p.R151C	SETDB1_uc009wmf.2_Missense_Mutation_p.R151C|SETDB1_uc001evv.2_Missense_Mutation_p.R151C|SETDB1_uc001evw.3_Missense_Mutation_p.R151C|SETDB1_uc009wmg.1_Missense_Mutation_p.R151C	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTACAGCTCCGTGAAGCTAT	0.388													4	18					0	0	0.009096	0	0
BNIPL	149428	broad.mit.edu	37	1	151018317	151018317	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:151018317G>A	uc001ewl.2	+	8	1069	c.896G>A	c.(895-897)TGG>TAG	p.W299*	BNIPL_uc009wmi.2_Nonsense_Mutation_p.W217*|BNIPL_uc009wmj.2_RNA|C1orf56_uc001ewn.2_5'Flank	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	299	CRAL-TRIO.				apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CATGCTACATGGTATGTGAAA	0.448													9	138					0	0	0.006214	0	0
ZNF687	57592	broad.mit.edu	37	1	151262922	151262922	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:151262922G>A	uc001exq.2	+	8	3190	c.3092G>A	c.(3091-3093)GGA>GAA	p.G1031E	ZNF687_uc009wmo.2_Missense_Mutation_p.G1031E|ZNF687_uc009wmp.2_Silent_p.G1051G	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	1031					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGCACAGAGGGAAAACGCACC	0.637													12	50					0	0	0.010729	0	0
RFX5	5993	broad.mit.edu	37	1	151314893	151314894	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:151314893_151314894GG>AA	uc001exv.1	-	11	1833_1834	c.1619_1620CC>TT	c.(1618-1620)TCC>TTT	p.S540F	RFX5_uc001exw.1_Missense_Mutation_p.S540F|RFX5_uc009wmr.1_Missense_Mutation_p.S540F|RFX5_uc010pcx.1_Missense_Mutation_p.S500F	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	540						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTCCTCCTTTGGAAACAGTACC	0.569													33	102					0	0	0.004672	0	0
TDRKH	11022	broad.mit.edu	37	1	151748309	151748309	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:151748309C>T	uc009wnb.1	-	9	1451	c.1269G>A	c.(1267-1269)CGG>CGA	p.R423R	TDRKH_uc001eyy.2_Silent_p.R199R|TDRKH_uc001ezb.3_Silent_p.R419R|TDRKH_uc001ezc.3_Silent_p.R378R|TDRKH_uc001eza.3_Silent_p.R423R|TDRKH_uc001ezd.3_Silent_p.R423R|TDRKH_uc010pdn.1_Silent_p.R199R	NM_006862	NP_006853	Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing isoform a	423							RNA binding			ovary(1)|pancreas(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGGGAGCAATCCGTGCCAGAC	0.408													37	92					0	0	0.009718	0	0
RPTN	126638	broad.mit.edu	37	1	152127432	152127432	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:152127432C>T	uc001ezs.1	-	3	2208	c.2143G>A	c.(2143-2145)GAT>AAT	p.D715N		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	715	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						CTGTGTCTATCCCAAGTTTGA	0.562													11	171					0	0	0.010729	0	0
RPTN	126638	broad.mit.edu	37	1	152129231	152129231	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:152129231C>T	uc001ezs.1	-	3	409	c.344G>A	c.(343-345)GGA>GAA	p.G115E		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	115	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						GCCTGTGTTTCCTGGGAACTT	0.527													31	193					0	0	0.010818	0	0
FLG	2312	broad.mit.edu	37	1	152281478	152281478	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:152281478C>T	uc001ezu.1	-	3	5920	c.5884G>A	c.(5884-5886)GAA>AAA	p.E1962K		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1962	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTCTGTCTTCGTGATGGGAC	0.567									Ichthyosis				31	323					0	0	0.012213	0	0
FLG	2312	broad.mit.edu	37	1	152282627	152282627	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:152282627C>T	uc001ezu.1	-	3	4771	c.4735G>A	c.(4735-4737)GGA>AGA	p.G1579R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1579	Ser-rich.|Filaggrin 9.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGATTCTCCCTGGCCCACC	0.587									Ichthyosis				13	150					0	0	0.002450	0	0
FLG2	388698	broad.mit.edu	37	1	152323257	152323257	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:152323257C>T	uc001ezw.3	-	3	7078	c.7005G>A	c.(7003-7005)AGG>AGA	p.R2335R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2335							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGCCTTTGCCTTTCACTAC	0.473													19	186					0	0	0.008871	0	0
FLG2	388698	broad.mit.edu	37	1	152326405	152326405	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:152326405T>C	uc001ezw.3	-	3	3930	c.3857A>G	c.(3856-3858)CAC>CGC	p.H1286R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1286	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAATGTCTGTGTGAGACCTT	0.478													20	229					0	0	0.008871	0	0
FLG2	388698	broad.mit.edu	37	1	152329352	152329352	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:152329352C>T	uc001ezw.3	-	3	983	c.910G>A	c.(910-912)GGA>AGA	p.G304R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	304	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTTGCCCTCCAAATCTATGT	0.483													10	131					0	0	0.010729	0	0
CRNN	49860	broad.mit.edu	37	1	152382994	152382994	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:152382994C>T	uc001ezx.2	-	3	638	c.564G>A	c.(562-564)CAG>CAA	p.Q188Q		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	188	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGCTCTGTCTGCCCAGAGA	0.572													22	217					0	0	0.003954	0	0
SPRR3	6707	broad.mit.edu	37	1	152975587	152975587	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:152975587G>A	uc001fax.3	+	3	241	c.91G>A	c.(91-93)GAA>AAA	p.E31K	SPRR3_uc001faz.3_Missense_Mutation_p.E31K|SPRR3_uc001fay.2_Missense_Mutation_p.E31K	NM_005416	NP_005407	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	31					keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			skin(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCCACCTCAGGAAATATTTGT	0.522													6	33					0	0	0.001984	0	0
LELP1	149018	broad.mit.edu	37	1	153177294	153177294	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:153177294G>A	uc001fbl.2	+	2	221	c.111G>A	c.(109-111)AAG>AAA	p.K37K		NM_001010857	NP_001010857	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	37	Cys/Pro-rich.									ovary(1)	1	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCTGTTTAAAGAAGCTGCTGC	0.512													21	56					0	0	0.014323	0	0
S100A7L2	645922	broad.mit.edu	37	1	153409698	153409698	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:153409698C>T	uc010pdx.1	-	3	253	c.175G>A	c.(175-177)GAA>AAA	p.E59K		NM_001045479	NP_001038944			S100 calcium binding protein A7-like 2											ovary(1)	1	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCGCTTTTTTCCTGCATGGAG	0.388													13	36					0	0	0.002450	0	0
INTS3	65123	broad.mit.edu	37	1	153719460	153719460	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:153719460C>T	uc009wom.2	+	5	567	c.346C>T	c.(346-348)CGT>TGT	p.R116C	INTS3_uc001fct.2_Missense_Mutation_p.R116C|INTS3_uc001fcu.2_5'UTR|INTS3_uc001fcv.2_5'UTR	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	116					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TCTGGTGAGTCGTGATGGCAT	0.488													10	115					0	0	0.008291	0	0
INTS3	65123	broad.mit.edu	37	1	153744397	153744398	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:153744397_153744398CC>TT	uc009wom.2	+	27	2899_2900	c.2678_2679CC>TT	c.(2677-2679)TCC>TTT	p.S893F	INTS3_uc001fct.2_Missense_Mutation_p.S893F|INTS3_uc001fcu.2_Missense_Mutation_p.S585F|INTS3_uc001fcv.2_Missense_Mutation_p.S687F|INTS3_uc010peb.1_Missense_Mutation_p.S687F|INTS3_uc001fcw.2_Missense_Mutation_p.S406F|INTS3_uc010pec.1_Missense_Mutation_p.S406F|INTS3_uc001fcy.2_Missense_Mutation_p.S190F|INTS3_uc001fcx.2_Missense_Mutation_p.S190F	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	894					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CACATCAAGTCCCTGCTCATCA	0.599											OREG0013827	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	26					0	0	0.004672	0	0
RAB13	5872	broad.mit.edu	37	1	153957211	153957211	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:153957211G>A	uc001fdt.1	-	2	265	c.171C>T	c.(169-171)ATC>ATT	p.I57I	RAB13_uc001fdu.1_Silent_p.I57I	NM_002870	NP_002861	P51153	RAB13_HUMAN	RAB13, member RAS oncogene family	57					cell adhesion|protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	cytoplasmic vesicle membrane|tight junction	GTP binding|GTPase activity				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTTGTAGTTTGATCTTCTTCC	0.443													13	24					0	0	0.004007	0	0
RPS27	6232	broad.mit.edu	37	1	153964547	153964547	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:153964547C>T	uc001fdv.2	+	4	267	c.233C>T	c.(232-234)TCC>TTC	p.S78F		NM_001030	NP_001021	P42677	RS27_HUMAN	ribosomal protein S27	78					cell proliferation|endocrine pancreas development|mitotic prometaphase|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleus	DNA binding|structural constituent of ribosome|zinc ion binding				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCAGGATGTTCCTTCAGGAGG	0.418													8	95					0	0	0.004482	0	0
UBAP2L	9898	broad.mit.edu	37	1	154218774	154218775	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:154218774_154218775CC>TT	uc001fep.3	+	11	1104_1105	c.937_938CC>TT	c.(937-939)CCT>TTT	p.P313F	UBAP2L_uc009wot.2_Missense_Mutation_p.P313F|UBAP2L_uc010pek.1_Missense_Mutation_p.P305F|UBAP2L_uc010pel.1_Missense_Mutation_p.P323F|UBAP2L_uc010pen.1_Missense_Mutation_p.P227F	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	313					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCTGGCCCAGCCTCTGGTGTTC	0.47													10	107					0	0	0.004672	0	0
ATP8B2	57198	broad.mit.edu	37	1	154315303	154315303	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:154315303C>T	uc001fex.2	+	15	1418	c.1418C>T	c.(1417-1419)CCT>CTT	p.P473L		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	459	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCCTTCAATCCTCTGGCTGAC	0.547													16	76					0	0	0.004007	0	0
KCNN3	3782	broad.mit.edu	37	1	154685942	154685942	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:154685942T>C	uc001ffp.2	-	7	2211	c.1897A>G	c.(1897-1899)AAG>GAG	p.K633E	KCNN3_uc001ffo.2_Missense_Mutation_p.K328E	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	638	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			CCACTCACCTTGGAAAGGTCC	0.562													5	56					0	0	0.001984	0	0
FLAD1	80308	broad.mit.edu	37	1	154962903	154962903	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:154962903C>T	uc001fgf.1	+	5	1807	c.1453C>T	c.(1453-1455)CTT>TTT	p.L485F	FLAD1_uc001fgd.1_3'UTR|FLAD1_uc001fge.1_Missense_Mutation_p.L388F|FLAD1_uc001fgg.1_Missense_Mutation_p.L388F|FLAD1_uc001fgh.1_Intron	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	485	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGAGGCTGTCCTTATGGGCAC	0.602													7	39					0	0	0.001984	0	0
DCST1	149095	broad.mit.edu	37	1	155011906	155011906	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:155011906C>T	uc001fgn.1	+	5	386	c.290C>T	c.(289-291)TCC>TTC	p.S97F	DCST1_uc010per.1_Missense_Mutation_p.S122F|DCST1_uc010pes.1_Missense_Mutation_p.S72F	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	97	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TGGGGGACCTCCCCTCACATC	0.607													26	73					0	0	0.006320	0	0
THBS3	7059	broad.mit.edu	37	1	155175068	155175068	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:155175068G>A	uc001fix.2	-	3	349	c.326C>T	c.(325-327)GCC>GTC	p.A109V	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Missense_Mutation_p.A109V|THBS3_uc001fiz.2_Missense_Mutation_p.A109V|THBS3_uc001fiy.2_5'UTR|THBS3_uc010pfu.1_Intron|THBS3_uc010pfv.1_Intron|THBS3_uc001fja.2_RNA|THBS3_uc009wqj.1_Missense_Mutation_p.A71V	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	109	TSP N-terminal.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TAGGTTCACGGCGTGGACTTT	0.642													4	42					0	0	0.000602	0	0
GON4L	54856	broad.mit.edu	37	1	155774905	155774905	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:155774905G>A	uc001flz.2	-	11	1577	c.1480C>T	c.(1480-1482)CGA>TGA	p.R494*	GON4L_uc001fly.1_Nonsense_Mutation_p.R494*|GON4L_uc009wrh.1_Nonsense_Mutation_p.R494*|GON4L_uc001fma.1_Nonsense_Mutation_p.R494*|GON4L_uc001fmc.2_Nonsense_Mutation_p.R494*|GON4L_uc001fmd.3_Nonsense_Mutation_p.R494*|GON4L_uc009wri.2_Nonsense_Mutation_p.R80*|GON4L_uc009wrj.1_Nonsense_Mutation_p.R9*|GON4L_uc001fme.2_Nonsense_Mutation_p.R322*|GON4L_uc001fmf.2_Nonsense_Mutation_p.R188*	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	494					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GAACGCGTTCGAAATGCAATG	0.468													7	47					0	0	0.003080	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155920222	155920222	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:155920222G>A	uc001fmt.2	-	21	2873	c.2755C>T	c.(2755-2757)CAT>TAT	p.H919Y	ARHGEF2_uc001fmq.2_Missense_Mutation_p.H157Y|ARHGEF2_uc001fmr.2_Missense_Mutation_p.H891Y|ARHGEF2_uc001fms.2_Missense_Mutation_p.H918Y|ARHGEF2_uc001fmu.2_Missense_Mutation_p.H963Y	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2	919					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					AAGTTTCGATGGACAGAGCGA	0.602													10	63					0	0	0.010729	0	0
IQGAP3	128239	broad.mit.edu	37	1	156518436	156518436	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:156518436G>A	uc001fpf.2	-	17	2005	c.1930C>T	c.(1930-1932)CCC>TCC	p.P644S		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	644					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCACAGTCGGGAACTACCCCT	0.607													6	68					0	0	0.001984	0	0
BCAN	63827	broad.mit.edu	37	1	156622516	156622517	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:156622516_156622517CC>TT	uc001fpp.2	+	8	2110_2111	c.1774_1775CC>TT	c.(1774-1776)CCT>TTT	p.P592F	BCAN_uc001fpo.2_Missense_Mutation_p.P592F	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	592					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGAGGGTGCCCCTTCCCTGCTT	0.629													7	28					0	0	0.004672	0	0
ISG20L2	81875	broad.mit.edu	37	1	156694055	156694055	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:156694055G>A	uc001fps.1	-	2	1094	c.833C>T	c.(832-834)TCC>TTC	p.S278F	ISG20L2_uc001fpt.1_Missense_Mutation_p.S278F	NM_030980	NP_112242	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene	278	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ACGGGTGAGGGACTTGGGGTG	0.542													9	62					0	0	0.006214	0	0
INSRR	3645	broad.mit.edu	37	1	156812213	156812213	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:156812213G>A	uc010pht.1	-	18	3468	c.3214C>T	c.(3214-3216)CGA>TGA	p.R1072*	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	1072	Cytoplasmic (Potential).|Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CGCAAAGATCGAAGATGGCTC	0.592													9	66					0	0	0.008291	0	0
ETV3	2117	broad.mit.edu	37	1	157105324	157105325	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:157105324_157105325GG>AA	uc001fqr.2	-	3	511_512	c.222_223CC>TT	c.(220-225)CGCCTC>CGTTTC	p.L75F	ETV3_uc001fqt.2_Missense_Mutation_p.L75F	NM_001145312	NP_001138784	P41162	ETV3_HUMAN	ets variant gene 3 isoform 1	75	ETS.						sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(266;0.158)	Prostate(1639;0.174)				CGGCCCCAGAGGCGGGCCACCT	0.54													7	36					0	0	0.004672	0	0
CD1E	913	broad.mit.edu	37	1	158324390	158324390	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158324390G>A	uc001fse.2	+	2	521	c.282G>A	c.(280-282)CAG>CAA	p.Q94Q	CD1E_uc010pid.1_Silent_p.Q92Q|CD1E_uc010pie.1_Intron|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Silent_p.Q94Q|CD1E_uc001fsk.2_Silent_p.Q94Q|CD1E_uc001fsj.2_Silent_p.Q94Q|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Silent_p.Q94Q|CD1E_uc001fry.2_Silent_p.Q94Q|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Silent_p.Q94Q|CD1E_uc009wsv.2_Intron|CD1E_uc001frz.2_Silent_p.Q94Q|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	94					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					AAAACTTACAGTCACTGTTCC	0.458													8	22					0	0	0.003080	0	0
CD1E	913	broad.mit.edu	37	1	158325230	158325230	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158325230C>T	uc001fse.2	+	3	735	c.496C>T	c.(496-498)CAG>TAG	p.Q166*	CD1E_uc010pid.1_Nonsense_Mutation_p.Q164*|CD1E_uc010pie.1_Nonsense_Mutation_p.Q67*|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Nonsense_Mutation_p.Q166*|CD1E_uc001fsk.2_Intron|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Nonsense_Mutation_p.Q166*|CD1E_uc001fry.2_Nonsense_Mutation_p.Q166*|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Nonsense_Mutation_p.Q166*|CD1E_uc009wsv.2_Nonsense_Mutation_p.Q67*|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	166					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					GATCCGGGCCCAGAACATCTG	0.483													6	59					0	0	0.001168	0	0
OR10K1	391109	broad.mit.edu	37	1	158436071	158436071	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158436071C>T	uc010pij.1	+	1	720	c.720C>T	c.(718-720)ACC>ACT	p.T240T		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CCTTCTCCACCTGTGCCTCCC	0.453													7	72					0	0	0.003080	0	0
OR10X1	128367	broad.mit.edu	37	1	158549373	158549373	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158549373C>T	uc010pin.1	-	1	317	c.317G>A	c.(316-318)AGA>AAA	p.R106K		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	106	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TGAAATGCTTCTGTCCTTGGC	0.478													7	67					0	0	0.001984	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576847	158576847	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158576847C>T	uc010pio.1	+	1	619	c.619C>T	c.(619-621)CTC>TTC	p.L207F		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TCTTTTGGTCCTCTTGGTCTC	0.522													8	101					0	0	0.004482	0	0
SPTA1	6708	broad.mit.edu	37	1	158590058	158590058	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158590058G>A	uc001fst.1	-	44	6518	c.6319C>T	c.(6319-6321)CAG>TAG	p.Q2107*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2107	Spectrin 20.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTAATCTGCTGGTCTAGCTCC	0.507													5	64					0	0	0.001168	0	0
SPTA1	6708	broad.mit.edu	37	1	158624529	158624530	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158624529_158624530CC>TT	uc001fst.1	-	21	3106_3107	c.2907_2908GG>AA	c.(2905-2910)CAGGCT>CAAACT	p.A970T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	970					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ACTGGTGCAGCCTGTTGTTGCT	0.515													6	35					0	0	0.004672	0	0
SPTA1	6708	broad.mit.edu	37	1	158637748	158637748	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158637748C>T	uc001fst.1	-	15	2137	c.1938G>A	c.(1936-1938)GAG>GAA	p.E646E		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	646	Spectrin 7.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCTCAATCATCTCTTGGCCAG	0.468													12	100					0	0	0.013537	0	0
SPTA1	6708	broad.mit.edu	37	1	158639531	158639531	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158639531C>T	uc001fst.1	-	13	1844	c.1645G>A	c.(1645-1647)GAT>AAT	p.D549N		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	549	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTCTCTGAATCATAATGGTCA	0.413													7	174					0	0	0.003080	0	0
SPTA1	6708	broad.mit.edu	37	1	158655074	158655074	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158655074C>T	uc001fst.1	-	2	287	c.88G>A	c.(88-90)GAA>AAA	p.E30K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	30	Spectrin 1.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GTCAACACTTCCTGACGCCTC	0.348													12	113					0	0	0.001855	0	0
OR6K6	128371	broad.mit.edu	37	1	158725174	158725174	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158725174G>A	uc001fsw.1	+	1	569	c.569G>A	c.(568-570)TGG>TAG	p.W190*		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					GAGATTGCATGGATTTCCACC	0.488													6	75					0	0	0.001984	0	0
OR6N1	128372	broad.mit.edu	37	1	158736211	158736211	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158736211C>T	uc010piq.1	-	1	262	c.262G>A	c.(262-264)GAG>AAG	p.E88K		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GTCTTTTTCTCACTGAGCAAG	0.488													14	53					0	0	0.002450	0	0
MNDA	4332	broad.mit.edu	37	1	158813785	158813785	+	Missense_Mutation	SNP	G	A	A	rs147313543		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:158813785G>A	uc001fsz.1	+	4	643	c.443G>A	c.(442-444)AGG>AAG	p.R148K		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	148					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding	p.R148R(1)		ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					GAAGCCAAAAGGAATAAGGTG	0.443													11	92					0	0	0.013537	0	0
DARC	2532	broad.mit.edu	37	1	159175649	159175649	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:159175649C>T	uc001fto.2	+	2	660	c.420C>T	c.(418-420)GCC>GCT	p.A140A	DARC_uc001ftp.3_Silent_p.A142A	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	140	Helical; Name=3; (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					ATGGCTCAGCCTTTGCCCAGG	0.632													3	31					0	0	0.004672	0	0
OR10J3	441911	broad.mit.edu	37	1	159283796	159283796	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:159283796G>A	uc010piu.1	-	1	654	c.654C>T	c.(652-654)TCC>TCT	p.S218S		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	218	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					TGAGGACATAGGAGATAAAGA	0.502													8	64					0	0	0.004482	0	0
OR10J5	127385	broad.mit.edu	37	1	159504990	159504990	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:159504990C>T	uc010piw.1	-	1	808	c.808G>A	c.(808-810)GAC>AAC	p.D270N		NM_001004469	NP_001004469	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_hematologic(112;0.0429)					AGAACAAGGTCTTTTTCTATT	0.483													5	42					0	0	0.001168	0	0
FCRL6	343413	broad.mit.edu	37	1	159778040	159778040	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:159778040G>A	uc001fud.3	+	3	167	c.125G>A	c.(124-126)TGG>TAG	p.W42*	FCRL6_uc010pix.1_Nonsense_Mutation_p.W37*|FCRL6_uc001fuc.2_Nonsense_Mutation_p.W49*|FCRL6_uc009wsz.1_Nonsense_Mutation_p.W42*|FCRL6_uc009wta.2_Nonsense_Mutation_p.W42*	NM_001004310	NP_001004310	Q6DN72	FCRL6_HUMAN	Fc receptor-like 6 precursor	42	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.0597)					TGTCAGGGATGGAAGAATACA	0.512													12	31					0	0	0.010729	0	0
FCRL6	343413	broad.mit.edu	37	1	159778082	159778082	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:159778082G>A	uc001fud.3	+	3	209	c.167G>A	c.(166-168)GGA>GAA	p.G56E	FCRL6_uc010pix.1_Missense_Mutation_p.G51E|FCRL6_uc001fuc.2_Missense_Mutation_p.G63E|FCRL6_uc009wsz.1_Missense_Mutation_p.G56E|FCRL6_uc009wta.2_Missense_Mutation_p.G56E	NM_001004310	NP_001004310	Q6DN72	FCRL6_HUMAN	Fc receptor-like 6 precursor	56	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.0597)					TACAGAGATGGAAAATTCCTT	0.507													4	27					0	0	0.009096	0	0
IGSF9	57549	broad.mit.edu	37	1	159901633	159901633	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:159901633C>T	uc001fur.2	-	11	1529	c.1331G>A	c.(1330-1332)GGG>GAG	p.G444E	IGSF9_uc001fuq.2_Missense_Mutation_p.G428E|IGSF9_uc001fup.2_5'UTR	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	444	Ig-like 5.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGAGGGTCCCCTTGGGCGGA	0.607													6	28					0	0	0.001168	0	0
IGSF9	57549	broad.mit.edu	37	1	159907562	159907562	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:159907562C>T	uc001fur.2	-	4	512	c.314G>A	c.(313-315)TGG>TAG	p.W105*	IGSF9_uc001fuq.2_Nonsense_Mutation_p.W105*	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	105	Ig-like 1.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GCACTCGTACCAGCCCTGGTC	0.592													5	40					0	0	0.001168	0	0
CD48	962	broad.mit.edu	37	1	160654855	160654855	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:160654855C>T	uc001fwn.2	-	2	239	c.207G>A	c.(205-207)TGG>TGA	p.W69*	CD48_uc001fwo.1_Nonsense_Mutation_p.W69*|CD48_uc001fwp.2_Nonsense_Mutation_p.W69*	NM_001778	NP_001769	P09326	CD48_HUMAN	CD48 molecule precursor	69	Ig-like C2-type 1.				blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding				0	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TTCTGGAATCCCATTCTACAA	0.443													15	47					0	0	0.003163	0	0
SLAMF7	57823	broad.mit.edu	37	1	160718154	160718154	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:160718154C>T	uc001fwq.2	+	2	241	c.226C>T	c.(226-228)CGT>TGT	p.R76C	SLAMF7_uc010pjn.1_Intron|SLAMF7_uc001fws.2_Intron|SLAMF7_uc001fwr.2_Missense_Mutation_p.R76C|SLAMF7_uc010pjo.1_Missense_Mutation_p.R76C|SLAMF7_uc010pjp.1_Intron|SLAMF7_uc010pjq.1_Missense_Mutation_p.R76C|SLAMF7_uc010pjr.1_Intron	NM_021181	NP_067004	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	76	Extracellular (Potential).				cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			skin(2)|ovary(1)	3	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GACCCAAAATCGTAATAGGGA	0.468													12	26					0	0	0.010729	0	0
SLAMF7	57823	broad.mit.edu	37	1	160720138	160720138	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:160720138C>T	uc001fwq.2	+	4	709	c.694C>T	c.(694-696)CTG>TTG	p.L232L	SLAMF7_uc010pjn.1_Silent_p.L138L|SLAMF7_uc001fws.2_Silent_p.L125L|SLAMF7_uc001fwr.2_Silent_p.L232L|SLAMF7_uc010pjo.1_Intron|SLAMF7_uc010pjp.1_Intron|SLAMF7_uc010pjq.1_Intron|SLAMF7_uc010pjr.1_Intron	NM_021181	NP_067004	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	232	Helical; (Potential).				cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			skin(2)|ovary(1)	3	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CCTGTGTCTCCTGTTGGTGCC	0.502													16	176					0	0	0.004990	0	0
SLAMF7	57823	broad.mit.edu	37	1	160720183	160720183	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:160720183C>T	uc001fwq.2	+	4	754	c.739C>T	c.(739-741)CTT>TTT	p.L247F	SLAMF7_uc010pjn.1_Missense_Mutation_p.L153F|SLAMF7_uc001fws.2_Missense_Mutation_p.L140F|SLAMF7_uc001fwr.2_Missense_Mutation_p.L247F|SLAMF7_uc010pjo.1_Intron|SLAMF7_uc010pjp.1_Intron|SLAMF7_uc010pjq.1_Intron|SLAMF7_uc010pjr.1_Intron	NM_021181	NP_067004	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	247	Helical; (Potential).				cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			skin(2)|ovary(1)	3	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GGGGCTATTTCTTTGGTTTCT	0.428													18	157					0	0	0.007413	0	0
ITLN1	55600	broad.mit.edu	37	1	160846564	160846564	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:160846564G>A	uc001fxc.2	-	8	948	c.832C>T	c.(832-834)CAG>TAG	p.Q278*		NM_017625	NP_060095	Q8WWA0	ITLN1_HUMAN	intelectin precursor	278					positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)	7	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCACACTGCTGGGGACTGGCC	0.498													5	78					0	0	0.001984	0	0
FCGR2A	2212	broad.mit.edu	37	1	161476213	161476213	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:161476213C>T	uc001gan.2	+	3	249	c.196C>T	c.(196-198)CGC>TGC	p.R66C	FCGR2A_uc001gam.2_Missense_Mutation_p.R65C|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	66	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCAGGGGGCTCGCAGCCCTGA	0.587													13	48					0	0	0.013537	0	0
FCGR3A	2214	broad.mit.edu	37	1	161514572	161514572	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:161514572C>T	uc001gat.3	-	5	633	c.496G>A	c.(496-498)GAC>AAC	p.D166N	FCGR3A_uc001gar.2_Missense_Mutation_p.D202N|FCGR3A_uc001gas.2_Missense_Mutation_p.D201N|FCGR3A_uc009wuh.2_Missense_Mutation_p.D165N|FCGR3A_uc009wui.2_Missense_Mutation_p.D166N	NM_001127595	NP_001121067	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor	166	Extracellular (Potential).|Ig-like C2-type 2.				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GAGCCGCTGTCTTTGAGTGTG	0.443													6	51					0	0	0.001984	0	0
FCRLB	127943	broad.mit.edu	37	1	161697269	161697270	+	Silent	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:161697269_161697270CC>TT	uc001gbh.2	+	8	1332_1333	c.1098_1099CC>TT	c.(1096-1101)GCCCTG>GCTTTG	p.366_367AL>AL	FCRLB_uc009wus.2_Silent_p.366_367AL>AL|FCRLB_uc001gbj.2_Missense_Mutation_p.P318L|FCRLB_uc001gbk.2_3'UTR|FCRLB_uc001gbl.2_Missense_Mutation_p.P311L|FCRLB_uc001gbm.2_3'UTR|FCRLB_uc001gbi.2_Silent_p.366_367AL>AL|FCRLB_uc001gbn.3_3'UTR	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	366_367						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CGGCTGGAGCCCTGAAACCCGA	0.673													6	59					0	0	0.004672	0	0
ATF6	22926	broad.mit.edu	37	1	161928372	161928372	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:161928372C>T	uc001gbr.2	+	16	2008	c.1941C>T	c.(1939-1941)ACC>ACT	p.T647T	ATF6_uc001gbs.2_RNA	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	647	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			AAACCAACACCTTCTTTGGCT	0.517													6	110					0	0	0.003080	0	0
NUF2	83540	broad.mit.edu	37	1	163306561	163306561	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:163306561T>G	uc001gcq.1	+	6	658	c.358T>G	c.(358-360)TTT>GTT	p.F120V	NUF2_uc001gcp.2_Missense_Mutation_p.F120V|NUF2_uc001gcr.1_Missense_Mutation_p.F120V|NUF2_uc009wvc.1_Missense_Mutation_p.F120V	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	120	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					GACAAGTCGGTTTTTAAGTGG	0.313													8	37					0	0	0.010729	0	0
LMX1A	4009	broad.mit.edu	37	1	165173169	165173169	+	Missense_Mutation	SNP	C	T	T	rs145918505		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:165173169C>T	uc001gcy.1	-	8	1318	c.1097G>A	c.(1096-1098)GGA>GAA	p.G366E	LMX1A_uc001gcz.1_Missense_Mutation_p.G366E|LMX1A_uc001gcw.1_Missense_Mutation_p.G84E|LMX1A_uc001gcx.1_Missense_Mutation_p.G117E	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	366						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					AATGGGGTTTCCCACTCTGGA	0.502													6	71					0	0	0.001984	0	0
LMX1A	4009	broad.mit.edu	37	1	165218696	165218696	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:165218696C>T	uc001gcy.1	-	3	666	c.445G>A	c.(445-447)GAG>AAG	p.E149K	LMX1A_uc001gcz.1_Missense_Mutation_p.E149K	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	149	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CGCTCCTTCTCATAGTCCCCT	0.622													13	34					0	0	0.002450	0	0
LRRC52	440699	broad.mit.edu	37	1	165532895	165532895	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:165532895G>A	uc001gde.2	+	2	832	c.776G>A	c.(775-777)GGA>GAA	p.G259E	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	259	Helical; (Potential).					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					TTCGCCGCGGGAACTGTGGCT	0.592													5	34					0	0	0.001984	0	0
ILDR2	387597	broad.mit.edu	37	1	166927185	166927185	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:166927185C>T	uc001gdx.1	-	2	256	c.200G>A	c.(199-201)GGA>GAA	p.G67E		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	67	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1						CAAGGATTCTCCCATGCGATC	0.547													13	105					0	0	0.003163	0	0
MAEL	84944	broad.mit.edu	37	1	166991040	166991040	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:166991040C>T	uc001gdy.1	+	12	1324	c.1253C>T	c.(1252-1254)TCA>TTA	p.S418L	MAEL_uc001gdz.1_Missense_Mutation_p.S387L|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	418					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						ACTTCACTCTCACCTTACATG	0.408													14	49					0	0	0.004007	0	0
DUSP27	92235	broad.mit.edu	37	1	167095239	167095239	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:167095239G>A	uc001geb.1	+	5	871	c.871G>A	c.(871-873)GGA>AGA	p.G291R		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	291					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CCGGGAGGGGGGATCAGCTGA	0.637													4	26					0	0	0.000602	0	0
ADCY10	55811	broad.mit.edu	37	1	167802296	167802296	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:167802296G>A	uc001ger.2	-	25	3820	c.3522C>T	c.(3520-3522)CTC>CTT	p.L1174L	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Silent_p.L1082L|ADCY10_uc010plj.1_Silent_p.L1021L	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1174					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						CATGGATATGGAGAAACAAGG	0.478													19	241					0	0	0.006122	0	0
GPR161	23432	broad.mit.edu	37	1	168054872	168054872	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:168054872C>T	uc001gfc.2	-	8	1801	c.1487G>A	c.(1486-1488)GGG>GAG	p.G496E	GPR161_uc001gfb.2_Missense_Mutation_p.G364E|GPR161_uc010pll.1_Missense_Mutation_p.G406E|GPR161_uc010plm.1_Missense_Mutation_p.G382E|GPR161_uc009wvo.2_Missense_Mutation_p.G513E|GPR161_uc001gfd.2_Missense_Mutation_p.G496E|GPR161_uc010pln.1_Missense_Mutation_p.G516E	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	496	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					GAAGCCGCCCCCCGGGACAGT	0.587													25	130					0	0	0.012213	0	0
DPT	1805	broad.mit.edu	37	1	168698112	168698112	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:168698112C>T	uc001gfp.2	-	1	317	c.301G>A	c.(301-303)GAA>AAA	p.E101K		NM_001937	NP_001928	Q07507	DERM_HUMAN	dermatopontin precursor	101	2 X 53-55 AA tandem repeats.|1-2.|3 X 6 AA repeats of D-R-[EQ]-W-[NQK]- [FY].				cell adhesion	extracellular space|proteinaceous extracellular matrix				ovary(1)	1	all_hematologic(923;0.208)					CCTTACCATTCCATGCCAGCC	0.582													15	50					0	0	0.003163	0	0
C1orf114	57821	broad.mit.edu	37	1	169391537	169391537	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:169391537C>T	uc001gga.1	-	3	300	c.132G>A	c.(130-132)AAG>AAA	p.K44K	C1orf114_uc001gfz.1_Silent_p.K44K|C1orf114_uc009wvq.1_Silent_p.K44K|C1orf114_uc001ggb.2_Silent_p.K44K|C1orf114_uc001ggc.1_Silent_p.K44K	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	44											0	all_hematologic(923;0.208)					TATTCTCTTCCTTCTCACAAG	0.348													3	38					0	0	0.004672	0	0
F5	2153	broad.mit.edu	37	1	169510306	169510306	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:169510306G>A	uc001ggg.1	-	13	4167	c.4022C>T	c.(4021-4023)CCA>CTA	p.P1341L		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1341	2-18.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ACTGAGTTCTGGAGAGAGGTT	0.527													70	196					0	0	0.014410	0	0
F5	2153	broad.mit.edu	37	1	169510946	169510946	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:169510946G>A	uc001ggg.1	-	13	3527	c.3382C>T	c.(3382-3384)CAA>TAA	p.Q1128*		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1128	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GGGAATGTTTGATAGTGTTCC	0.483													11	123					0	0	0.013537	0	0
C1orf129	80133	broad.mit.edu	37	1	170961428	170961428	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:170961428G>A	uc001ghg.2	+	12	1282	c.1152G>A	c.(1150-1152)GGG>GGA	p.G384G	C1orf129_uc009wvy.2_Silent_p.G191G|C1orf129_uc010plz.1_Silent_p.G384G	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	384							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TAACGGAAGGGAAACGTTTCT	0.458													6	82					0	0	0.001168	0	0
FMO1	2326	broad.mit.edu	37	1	171236709	171236709	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:171236709C>T	uc009wvz.2	+	3	296	c.160C>T	c.(160-162)CTC>TTC	p.L54F	FMO1_uc010pme.1_Intron|FMO1_uc001ghl.2_Missense_Mutation_p.L54F|FMO1_uc001ghm.2_Missense_Mutation_p.L54F|FMO1_uc001ghn.2_Missense_Mutation_p.L54F	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	54					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAGAGCCAGTCTCTACAAGTC	0.433													6	80					0	0	0.003080	0	0
FMO1	2326	broad.mit.edu	37	1	171254612	171254612	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:171254612C>T	uc009wvz.2	+	9	1664	c.1528C>T	c.(1528-1530)CCC>TCC	p.P510S	FMO1_uc010pme.1_Missense_Mutation_p.P447S|FMO1_uc001ghl.2_Missense_Mutation_p.P510S|FMO1_uc001ghm.2_Missense_Mutation_p.P510S|FMO1_uc001ghn.2_3'UTR	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	510					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GTCTCCATCTCCCTTTGAAAG	0.423													4	52					0	0	0.009096	0	0
TNR	7143	broad.mit.edu	37	1	175331865	175331865	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:175331865C>T	uc001gkp.1	-	12	2869	c.2788G>A	c.(2788-2790)GAA>AAA	p.E930K	TNR_uc009wwu.1_Missense_Mutation_p.E930K	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	930	Fibronectin type-III 7.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					AGGCTGATTTCGTATTCGGTA	0.532													6	89					0	0	0.001168	0	0
TNR	7143	broad.mit.edu	37	1	175332963	175332963	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:175332963C>T	uc001gkp.1	-	11	2669	c.2588G>A	c.(2587-2589)GGA>GAA	p.G863E	TNR_uc009wwu.1_Missense_Mutation_p.G863E	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	863	Fibronectin type-III 7.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GGGATCAATTCCTACAAGGAC	0.443													4	55					0	0	0.000602	0	0
TNR	7143	broad.mit.edu	37	1	175355315	175355315	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:175355315C>T	uc001gkp.1	-	6	1711	c.1630G>A	c.(1630-1632)GAA>AAA	p.E544K	TNR_uc009wwu.1_Missense_Mutation_p.E544K	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	544	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CTCCCACCTTCCCCGCCCACC	0.597													9	18					0	0	0.004482	0	0
TNR	7143	broad.mit.edu	37	1	175375790	175375790	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:175375790G>A	uc001gkp.1	-	1	142	c.61C>T	c.(61-63)CTT>TTT	p.L21F	TNR_uc009wwu.1_Missense_Mutation_p.L21F|TNR_uc010pmz.1_Missense_Mutation_p.L21F	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	21					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GAGCCCAGAAGGATCAGGTTG	0.552													4	96					0	0	0.000602	0	0
PAPPA2	60676	broad.mit.edu	37	1	176679217	176679217	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:176679217G>A	uc001gkz.2	+	11	4720	c.3556G>A	c.(3556-3558)GGA>AGA	p.G1186R	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1186					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CACTCCCAAAGGATACTTGGA	0.463													11	103					0	0	0.013537	0	0
PAPPA2	60676	broad.mit.edu	37	1	176734809	176734809	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:176734809C>T	uc001gkz.2	+	15	5323	c.4159C>T	c.(4159-4161)CAT>TAT	p.H1387Y	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1387					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CAGCTGTATCCATCGGCCCTG	0.507													10	129					0	0	0.003163	0	0
PAPPA2	60676	broad.mit.edu	37	1	176758951	176758951	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:176758951C>T	uc001gkz.2	+	18	5886	c.4722C>T	c.(4720-4722)CTC>CTT	p.L1574L	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1574	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TCAGCAAGCTCCTGAAGATAC	0.428													8	9					0	0	0.003080	0	0
ASTN1	460	broad.mit.edu	37	1	176903371	176903371	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:176903371C>T	uc001glc.2	-	16	2800	c.2588G>A	c.(2587-2589)GGC>GAC	p.G863D	ASTN1_uc001glb.1_Missense_Mutation_p.G863D|ASTN1_uc001gld.1_Missense_Mutation_p.G863D	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	871					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CTCCTCAAAGCCGTAGATAGC	0.522													6	47					0	0	0.001168	0	0
FAM5B	57795	broad.mit.edu	37	1	177250216	177250216	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:177250216G>A	uc001glf.2	+	8	2216	c.1904G>A	c.(1903-1905)TGG>TAG	p.W635*	FAM5B_uc001glg.2_Nonsense_Mutation_p.W530*	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	635						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GGGAATAGGTGGAAGACTTTC	0.498													4	46					0	0	0.000602	0	0
ABL2	27	broad.mit.edu	37	1	179078078	179078078	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:179078078G>A	uc001gmj.3	-	12	2611	c.2324C>T	c.(2323-2325)TCC>TTC	p.S775F	ABL2_uc010pnf.1_Intron|ABL2_uc010png.1_Intron|ABL2_uc010pnh.1_Missense_Mutation_p.S754F|ABL2_uc001gmg.3_Intron|ABL2_uc001gmi.3_Missense_Mutation_p.S760F|ABL2_uc001gmh.3_Missense_Mutation_p.S739F|ABL2_uc010pne.1_Intron	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	775	F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	AAAAGGCTTGGAAGTGTCATC	0.527			T	ETV6	AML								12	134					0	0	0.002450	0	0
ABL2	27	broad.mit.edu	37	1	179078467	179078468	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:179078467_179078468GG>AA	uc001gmj.3	-	12	2221_2222	c.1934_1935CC>TT	c.(1933-1935)ACC>ATT	p.T645I	ABL2_uc010pnf.1_Missense_Mutation_p.T645I|ABL2_uc010png.1_Missense_Mutation_p.T624I|ABL2_uc010pnh.1_Missense_Mutation_p.T624I|ABL2_uc001gmg.3_Missense_Mutation_p.T630I|ABL2_uc001gmi.3_Missense_Mutation_p.T630I|ABL2_uc001gmh.3_Missense_Mutation_p.T609I|ABL2_uc010pne.1_Missense_Mutation_p.T609I	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	645					axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TCCTATCCCTGGTGAAGCATGT	0.54			T	ETV6	AML								16	130					0	0	0.004672	0	0
TDRD5	163589	broad.mit.edu	37	1	179561865	179561865	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:179561865G>A	uc001gnf.1	+	2	365	c.115G>A	c.(115-117)GTT>ATT	p.V39I	TDRD5_uc010pnp.1_Missense_Mutation_p.V39I|uc010pno.1_5'Flank	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	39	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CCTTTTGATGGTTGGCAACCA	0.507													13	106					0	0	0.013537	0	0
TDRD5	163589	broad.mit.edu	37	1	179609006	179609006	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:179609006G>A	uc001gnf.1	+	10	1803	c.1553G>A	c.(1552-1554)CGA>CAA	p.R518Q	TDRD5_uc010pnp.1_Missense_Mutation_p.R518Q|TDRD5_uc001gnh.1_Missense_Mutation_p.R73Q	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	518					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						GTTTCTGATCGATATGTCATG	0.383													6	100					0	0	0.001168	0	0
TDRD5	163589	broad.mit.edu	37	1	179620077	179620077	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:179620077G>A	uc001gnf.1	+	12	2126	c.1876G>A	c.(1876-1878)GAA>AAA	p.E626K	TDRD5_uc010pnp.1_Missense_Mutation_p.E626K|TDRD5_uc001gnh.1_Missense_Mutation_p.E181K	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	626					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						GGTAGTGGATGAATATGTAGA	0.398													9	77					0	0	0.008291	0	0
CEP350	9857	broad.mit.edu	37	1	179989791	179989791	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:179989791C>T	uc001gnt.2	+	12	3265	c.2882C>T	c.(2881-2883)TCT>TTT	p.S961F	CEP350_uc009wxl.2_Missense_Mutation_p.S960F|CEP350_uc001gnu.2_Missense_Mutation_p.S795F	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	961						centrosome|nucleus|spindle				ovary(4)	4						TCTTCTAGCTCTGATATGCAA	0.473													11	116					0	0	0.008291	0	0
CACNA1E	777	broad.mit.edu	37	1	181686317	181686317	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:181686317C>T	uc001gow.2	+	11	1569	c.1404C>T	c.(1402-1404)TCC>TCT	p.S468S	CACNA1E_uc009wxs.2_Silent_p.S375S	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	468	Cytoplasmic (Potential).|II.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TGCGCATCTCCATTCGCCACA	0.532													11	75					0	0	0.013537	0	0
RNASEL	6041	broad.mit.edu	37	1	182551267	182551267	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:182551267G>A	uc001gpj.1	-	3	1860	c.1693C>T	c.(1693-1695)CGT>TGT	p.R565C	RNASEL_uc009wxz.1_Missense_Mutation_p.R565C|RNASEL_uc001gpk.2_Missense_Mutation_p.R565C|RNASEL_uc009wya.1_3'UTR	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	565	Protein kinase.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						TGGAAGAGACGATGAATGAgg	0.378									Hereditary_Prostate_Cancer				30	84					0	0	0.009535	0	0
RGS8	85397	broad.mit.edu	37	1	182617422	182617422	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:182617422G>A	uc010pnw.1	-	6	468	c.210C>T	c.(208-210)TTC>TTT	p.F70F	RGS8_uc001gpn.1_Silent_p.F70F|RGS8_uc001gpm.1_Silent_p.F88F	NM_001102450	NP_001095920	P57771	RGS8_HUMAN	regulator of G-protein signalling 8 isoform 2	70	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)	1						AGAAGGCACGGAATGCAGCCA	0.463													28	148					0	0	0.007291	0	0
DHX9	1660	broad.mit.edu	37	1	182856252	182856252	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:182856252C>G	uc001gpr.2	+	28	3659	c.3496C>G	c.(3496-3498)CGA>GGA	p.R1166G	DHX9_uc001gps.2_Missense_Mutation_p.R952G|DHX9_uc001gpt.2_Missense_Mutation_p.R445G|DHX9_uc009wyd.2_Missense_Mutation_p.R131G	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	1166	NTD.			R->L: Abolishes nuclear localization.|Missing: Abolishes nuclear localization.	CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						CAAGATGGCCCGATACGACAA	0.483													7	106					0	0	0.001984	0	0
LAMC2	3918	broad.mit.edu	37	1	183177070	183177070	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:183177070G>A	uc001gqa.2	+	2	448	c.134G>A	c.(133-135)AGA>AAA	p.R45K	LAMC2_uc001gpz.3_Missense_Mutation_p.R45K|LAMC2_uc010poa.1_5'UTR	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	45	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						GAACTTCACAGACAAACTGGT	0.448													10	193					0	0	0.006214	0	0
LAMC2	3918	broad.mit.edu	37	1	183212290	183212290	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:183212290C>T	uc001gqa.2	+	23	3651	c.3337C>T	c.(3337-3339)CTC>TTC	p.L1113F		NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	1113	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						AGACCAGCCTCTCAGTGTAGA	0.483													7	62					0	0	0.001984	0	0
SMG7	9887	broad.mit.edu	37	1	183515121	183515121	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:183515121C>T	uc001gqg.2	+	17	2513	c.2391C>T	c.(2389-2391)TCC>TCT	p.S797S	SMG7_uc010pob.1_Silent_p.S780S|SMG7_uc001gqf.2_Silent_p.S751S|SMG7_uc001gqh.2_Silent_p.S751S|SMG7_uc001gqi.2_Silent_p.S709S|SMG7_uc010poc.1_Silent_p.S755S	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	797	Gln/Pro-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CAGATGCCTCCAAACAGCTGT	0.418													6	60					0	0	0.001168	0	0
FAM129A	116496	broad.mit.edu	37	1	184787840	184787840	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:184787840A>G	uc001gra.2	-	9	1299	c.1105T>C	c.(1105-1107)TTT>CTT	p.F369L	FAM129A_uc001grb.1_Missense_Mutation_p.F132L|FAM129A_uc009wyh.1_Missense_Mutation_p.F197L|FAM129A_uc009wyi.1_Missense_Mutation_p.F167L	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	369					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						TCTTTCTCAAAGAGTACACGT	0.512													35	101					0	0	0.003271	0	0
HMCN1	83872	broad.mit.edu	37	1	186099733	186099734	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:186099733_186099734CC>TT	uc001grq.1	+	85	13363_13364	c.13134_13135CC>TT	c.(13132-13137)ACCCCA>ACTTCA	p.P4379S	HMCN1_uc001grs.1_5'UTR	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4379	Ig-like C2-type 43.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAGACCCCACCCCAACCATCCA	0.485													11	72					0	0	0.004672	0	0
PRG4	10216	broad.mit.edu	37	1	186278155	186278155	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:186278155G>A	uc001gru.3	+	7	3355	c.3304G>A	c.(3304-3306)GGA>AGA	p.G1102R	PRG4_uc001grt.3_Missense_Mutation_p.G1061R|PRG4_uc009wyl.2_Missense_Mutation_p.G1009R|PRG4_uc009wym.2_Missense_Mutation_p.G968R|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1102					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						TGGTGCTGAAGGAGAAACACC	0.463													5	32					0	0	0.000602	0	0
FAM5C	339479	broad.mit.edu	37	1	190067291	190067291	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:190067291G>A	uc001gse.1	-	8	2390	c.2158C>T	c.(2158-2160)CGT>TGT	p.R720C	FAM5C_uc010pot.1_Missense_Mutation_p.R618C	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	720						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AGATCTAGACGACGCTGACCA	0.478													14	59					0	0	0.004007	0	0
FAM5C	339479	broad.mit.edu	37	1	190129977	190129977	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:190129977G>A	uc001gse.1	-	7	1237	c.1005C>T	c.(1003-1005)TTC>TTT	p.F335F	FAM5C_uc010pot.1_Silent_p.F233F	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	335						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					ATGTGTTGAGGAAATAATTCA	0.299													14	96					0	0	0.004007	0	0
KCNT2	343450	broad.mit.edu	37	1	196458988	196458988	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:196458988G>A	uc001gtd.1	-	3	315	c.255C>T	c.(253-255)AAC>AAT	p.N85N	KCNT2_uc001gte.1_Silent_p.N85N|KCNT2_uc001gtf.1_Silent_p.N85N|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Silent_p.N85N|KCNT2_uc009wyv.1_Silent_p.N85N	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	85	Extracellular (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CTTGTGAAGGGTTTTCTAGTA	0.294													5	98					0	0	0.001168	0	0
CFH	3075	broad.mit.edu	37	1	196648818	196648818	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:196648818G>A	uc001gtj.3	+	6	925	c.685G>A	c.(685-687)GAG>AAG	p.E229K	CFH_uc001gti.3_Missense_Mutation_p.E229K|CFH_uc009wyw.2_Missense_Mutation_p.E229K|CFH_uc009wyx.2_Missense_Mutation_p.E165K	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	229	Sushi 4.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TATTTATAAGGAGAATGAACG	0.333													8	31					0	0	0.006214	0	0
CFH	3075	broad.mit.edu	37	1	196694341	196694341	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:196694341C>T	uc001gtj.3	+	12	2027	c.1787C>T	c.(1786-1788)TCC>TTC	p.S596F		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	596	Sushi 10.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TTGAAATTCTCCTGCAAACCA	0.393													19	39					0	0	0.010504	0	0
CFH	3075	broad.mit.edu	37	1	196695653	196695653	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:196695653G>A	uc001gtj.3	+	13	2167	c.1927G>A	c.(1927-1929)GAA>AAA	p.E643K		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	643	Sushi 11.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GAATGTTAAGGAAAAAACGAA	0.343													9	26					0	0	0.006214	0	0
CFH	3075	broad.mit.edu	37	1	196715005	196715005	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:196715005C>T	uc001gtj.3	+	21	3609	c.3369C>T	c.(3367-3369)TTC>TTT	p.F1123F		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1123	Sushi 19.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TTACTTCATTCCCGTTGTCAG	0.403													7	76					0	0	0.008291	0	0
CFHR3	10878	broad.mit.edu	37	1	196762609	196762609	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:196762609G>A	uc001gtl.2	+	6	1046	c.959G>A	c.(958-960)CGG>CAG	p.R320Q	CFHR3_uc010poy.1_Missense_Mutation_p.R259Q|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	320	Sushi 5.					extracellular space					0						GCAGTGTGTCGGGAAGGGATA	0.378													6	55					0	0	0.003080	0	0
CFHR1	3078	broad.mit.edu	37	1	196799639	196799639	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:196799639G>A	uc001gtn.2	+	5	731	c.617G>A	c.(616-618)GGA>GAA	p.G206E	CFHR1_uc001gtm.2_Missense_Mutation_p.G110E	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	206	Sushi 4.				complement activation	extracellular space					0						GATTCTACGGGAAAATGTGGG	0.383													14	84					0	0	0.002450	0	0
CFHR2	3080	broad.mit.edu	37	1	196928040	196928040	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:196928040G>A	uc001gtq.1	+	5	720	c.643G>A	c.(643-645)GAA>AAA	p.E215K	CFHR2_uc001gtr.1_Missense_Mutation_p.E91K	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	215	Sushi 4.					extracellular region				skin(2)|ovary(1)	3						AGAAATTATGGAAAAATATAA	0.284													4	28					0	0	0.009096	0	0
F13B	2165	broad.mit.edu	37	1	197009662	197009662	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:197009662G>A	uc001gtt.1	-	11	1986	c.1942C>T	c.(1942-1944)CCA>TCA	p.P648S		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	648					blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CTTTGTCTTGGAATACATCTT	0.299													5	43					0	0	0.001984	0	0
ASPM	259266	broad.mit.edu	37	1	197071057	197071057	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:197071057G>A	uc001gtu.2	-	18	7581	c.7324C>T	c.(7324-7326)CGA>TGA	p.R2442*	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Nonsense_Mutation_p.R290*	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2442					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ATGGTGGCTCGATATTTCCTC	0.373													5	80					0	0	0.000602	0	0
ASPM	259266	broad.mit.edu	37	1	197071456	197071456	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:197071456G>A	uc001gtu.2	-	18	7182	c.6925C>T	c.(6925-6927)CTT>TTT	p.L2309F	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.L157F	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2309					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TGTACCTGAAGGAACTGTAAG	0.383													7	79					0	0	0.001984	0	0
ASPM	259266	broad.mit.edu	37	1	197072844	197072844	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:197072844G>A	uc001gtu.2	-	18	5794	c.5537C>T	c.(5536-5538)TCT>TTT	p.S1846F	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1846	IQ 9.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTGAAGCACAGATTGATATTT	0.348													13	70					0	0	0.002450	0	0
ASPM	259266	broad.mit.edu	37	1	197072848	197072848	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:197072848G>A	uc001gtu.2	-	18	5790	c.5533C>T	c.(5533-5535)CAA>TAA	p.Q1845*	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1845	IQ 9.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						AGCACAGATTGATATTTTACC	0.348													5	79					0	0	0.000602	0	0
CRB1	23418	broad.mit.edu	37	1	197396979	197396979	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:197396979G>A	uc001gtz.2	+	7	2659	c.2524G>A	c.(2524-2526)GAA>AAA	p.E842K	CRB1_uc010poz.1_Missense_Mutation_p.E773K|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.E730K|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.E323K|CRB1_uc001gub.1_Missense_Mutation_p.E491K	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	842	Extracellular (Potential).|Laminin G-like 2.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GCAAGAGACTGAACTTAATGG	0.388													7	32					0	0	0.006214	0	0
PTPRC	5788	broad.mit.edu	37	1	198685878	198685878	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:198685878G>A	uc001gur.1	+	13	1533	c.1353G>A	c.(1351-1353)ACG>ACA	p.T451T	PTPRC_uc001gus.1_Silent_p.T403T|PTPRC_uc001gut.1_Silent_p.T290T|PTPRC_uc009wzf.1_Silent_p.T339T|PTPRC_uc010ppg.1_Silent_p.T387T	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	451	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						AACCTTATACGAAATATGTTT	0.308													7	55					0	0	0.001984	0	0
PTPRC	5788	broad.mit.edu	37	1	198701516	198701516	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:198701516C>T	uc001gur.1	+	19	2236	c.2056C>T	c.(2056-2058)CCT>TCT	p.P686S	PTPRC_uc001gus.1_Missense_Mutation_p.P638S|PTPRC_uc001gut.1_Missense_Mutation_p.P525S|PTPRC_uc009wzf.1_Missense_Mutation_p.P574S|PTPRC_uc010ppg.1_Missense_Mutation_p.P622S	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	686	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TGACATTCTTCCTTGTGAGTA	0.348													4	39					0	0	0.009096	0	0
DDX59	83479	broad.mit.edu	37	1	200618354	200618354	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:200618354C>T	uc009wzk.2	-	6	1558	c.1315G>A	c.(1315-1317)GAT>AAT	p.D439N	DDX59_uc010ppl.1_Missense_Mutation_p.D439N	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	439	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						AGTTTCTTATCCTGaaaaatt	0.294													4	58					0	0	0.009096	0	0
CACNA1S	779	broad.mit.edu	37	1	201008964	201008964	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:201008964G>A	uc001gvv.2	-	44	5844	c.5617C>T	c.(5617-5619)CTG>TTG	p.L1873L		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1873	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GGGCATCACAGCCTTGGAGGA	0.637													5	55					0	0	0.001168	0	0
CACNA1S	779	broad.mit.edu	37	1	201012616	201012616	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:201012616C>T	uc001gvv.2	-	40	5068	c.4841G>A	c.(4840-4842)AGG>AAG	p.R1614K		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1614	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GGAGTTGGTCCTTTCCAGGAA	0.592											OREG0014067	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	50					0	0	0.001984	0	0
IGFN1	91156	broad.mit.edu	37	1	201186547	201186547	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:201186547G>A	uc001gwc.2	+	6	1980	c.1208G>A	c.(1207-1209)GGG>GAG	p.G403E	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CGTAAGAAGGGGAGCAACACC	0.642													7	44					0	0	0.001984	0	0
ELF3	1999	broad.mit.edu	37	1	201982372	201982372	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:201982372C>T	uc001gxg.3	+	6	3943	c.751C>T	c.(751-753)CGA>TGA	p.R251*	ELF3_uc001gxi.3_Nonsense_Mutation_p.R251*|ELF3_uc001gxh.3_Nonsense_Mutation_p.R251*	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	251					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						AGGCCGGCCCCGAAAGCTGAG	0.637													11	41					0	0	0.010729	0	0
LGR6	59352	broad.mit.edu	37	1	202287170	202287170	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:202287170G>A	uc001gxu.2	+	18	1739	c.1739G>A	c.(1738-1740)GGA>GAA	p.G580E	LGR6_uc001gxv.2_Missense_Mutation_p.G528E|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.G441E	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	580	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						CTCTGCAATGGACTGGTGCTG	0.617													24	54					0	0	0.004656	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202391804	202391804	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:202391804C>T	uc001gya.1	+	3	623	c.479C>T	c.(478-480)CCC>CTC	p.P160L	PPP1R12B_uc001gxy.2_Missense_Mutation_p.P160L|PPP1R12B_uc009xad.1_Intron|PPP1R12B_uc009xae.1_Missense_Mutation_p.P160L|PPP1R12B_uc001gxz.1_Missense_Mutation_p.P160L	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	160					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GGTGAAGTTCCCTCTGACCTT	0.443													4	55					0	0	0.001984	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202464720	202464720	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:202464720T>G	uc001gya.1	+	17	2502	c.2358T>G	c.(2356-2358)GAT>GAG	p.D786E	PPP1R12B_uc001gxz.1_Missense_Mutation_p.D786E|PPP1R12B_uc001gyb.1_Missense_Mutation_p.D12E|PPP1R12B_uc001gyc.1_Missense_Mutation_p.D12E	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	786					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			CAGATTTGGATGAGCAGTCCT	0.478													3	32					0	0	0.004672	0	0
KLHL12	59349	broad.mit.edu	37	1	202864694	202864694	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:202864694G>A	uc001gyo.1	-	8	1291	c.1091C>T	c.(1090-1092)CCT>CTT	p.P364L	KLHL12_uc001gym.1_Missense_Mutation_p.P97L|KLHL12_uc001gyn.1_Missense_Mutation_p.P214L|KLHL12_uc010pqc.1_Missense_Mutation_p.P402L|KLHL12_uc009xah.1_Intron	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	364	Kelch 2.				Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			GACATTCATAGGGGCCACAGA	0.532													10	21					0	0	0.008291	0	0
CHIT1	1118	broad.mit.edu	37	1	203194880	203194880	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:203194880G>A	uc001gzn.2	-	3	270	c.174C>T	c.(172-174)TTC>TTT	p.F58F	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_5'Flank|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Silent_p.F68F	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	58					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						TCATGCCAGCGAAGGCGTAGA	0.572													12	68					0	0	0.002450	0	0
LRRN2	10446	broad.mit.edu	37	1	204588781	204588781	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:204588781G>A	uc001hbe.1	-	3	728	c.340C>T	c.(340-342)CAT>TAT	p.H114Y	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.H114Y|LRRN2_uc009xbf.1_Missense_Mutation_p.H114Y|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	114	LRR 2.|Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GGCAGGGCATGGAAATCACAG	0.597													19	92					0	0	0.006122	0	0
NFASC	23114	broad.mit.edu	37	1	204924007	204924007	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:204924007G>A	uc001hbj.2	+	7	791	c.463G>A	c.(463-465)GGC>AGC	p.G155S	NFASC_uc001hbh.2_Missense_Mutation_p.G155S|NFASC_uc010pqz.1_Missense_Mutation_p.G149S|NFASC_uc010pra.1_Missense_Mutation_p.G149S|NFASC_uc001hbi.2_Missense_Mutation_p.G149S|NFASC_uc009xbg.1_Missense_Mutation_p.G222S|NFASC_uc010prb.1_Missense_Mutation_p.G149S|NFASC_uc010prc.1_5'UTR|NFASC_uc001hbk.1_5'Flank	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	155	Extracellular (Potential).|Ig-like C2-type 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGTCCAAGAGGGCGCTCCTTT	0.582													38	101					0	0	0.006999	0	0
NFASC	23114	broad.mit.edu	37	1	204966327	204966327	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:204966327G>A	uc001hbj.2	+	25	3140	c.2812G>A	c.(2812-2814)GGT>AGT	p.G938S	NFASC_uc010pra.1_Intron|NFASC_uc001hbi.2_Intron|NFASC_uc010prb.1_Intron|NFASC_uc010prc.1_Intron|NFASC_uc001hbl.1_Intron|NFASC_uc001hbm.1_Intron|NFASC_uc001hbn.1_Missense_Mutation_p.G84S|NFASC_uc009xbh.1_5'UTR	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GACTACCGTGGGTGCGACGGG	0.592													9	38					0	0	0.010729	0	0
IKBKE	9641	broad.mit.edu	37	1	206651605	206651605	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:206651605C>T	uc001hdz.1	+	9	1283	c.915C>T	c.(913-915)ATC>ATT	p.I305I	IKBKE_uc009xbu.1_3'UTR|IKBKE_uc009xbv.1_Silent_p.I305I|IKBKE_uc001hea.1_Silent_p.I220I	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	305	Protein kinase.				DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					CCAGTGACATCCTGCAGCGAG	0.602													17	124					0	0	0.004990	0	0
IL19	29949	broad.mit.edu	37	1	206972280	206972280	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:206972280C>T	uc001heo.2	+	1	66	c.41C>T	c.(40-42)TCC>TTC	p.S14F		NM_153758	NP_715639	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 1 precursor	Error:Variant_position_missing_in_Q9UHD0_after_alignment					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			TCTGCGTGTTCCTTACCACTC	0.507													28	47					0	0	0.009535	0	0
FAIM3	9214	broad.mit.edu	37	1	207086368	207086368	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:207086368T>C	uc001hey.2	-	3	572	c.393A>G	c.(391-393)GAA>GAG	p.E131E	FAIM3_uc010prz.1_Silent_p.E19E|FAIM3_uc010psa.1_Silent_p.E40E|FAIM3_uc010psb.1_Silent_p.E131E	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	131	Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					TTGGCTGCTCTTCCCATGATG	0.468											OREG0014185	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	246					0	0	0.004990	0	0
CR2	1380	broad.mit.edu	37	1	207644767	207644767	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:207644767G>A	uc001hfw.2	+	9	1588	c.1494_splice	c.e9-1	p.G498_splice	CR2_uc001hfv.2_Splice_Site_p.G498_splice|CR2_uc009xch.2_Splice_Site_p.G498_splice|CR2_uc009xci.1_Intron	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)						complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TCTGTCTCTAGGTACAAGTTA	0.438													7	73					0	0	0.006214	0	0
CR2	1380	broad.mit.edu	37	1	207644832	207644832	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:207644832C>T	uc001hfw.2	+	9	1652	c.1558C>T	c.(1558-1560)CGT>TGT	p.R520C	CR2_uc001hfv.2_Missense_Mutation_p.R520C|CR2_uc009xch.2_Missense_Mutation_p.R520C|CR2_uc009xci.1_Intron	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	520	Sushi 8.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TATGGAGATTCGTCTTTGTAA	0.383													13	61					0	0	0.003163	0	0
CR1	1378	broad.mit.edu	37	1	207789980	207789980	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:207789980G>A	uc001hfy.2	+	33	5512	c.5372G>A	c.(5371-5373)GGA>GAA	p.G1791E	CR1_uc001hfx.2_Missense_Mutation_p.G2241E	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1791	Sushi 28.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						ACTCCCTTTGGAGATATTCCC	0.438													8	102					0	0	0.008291	0	0
LAMB3	3914	broad.mit.edu	37	1	209796444	209796444	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:209796444G>A	uc001hhg.2	-	16	2829	c.2439C>T	c.(2437-2439)GCC>GCT	p.A813A	LAMB3_uc009xco.2_Silent_p.A813A|LAMB3_uc001hhh.2_Silent_p.A813A|LAMB3_uc010psl.1_RNA	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	813	Domain alpha.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGGAGCCACAGGCTGTGCCAT	0.637													12	49					0	0	0.013537	0	0
IRF6	3664	broad.mit.edu	37	1	209961957	209961957	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:209961957C>T	uc001hhq.1	-	9	1475	c.1212G>A	c.(1210-1212)GAG>GAA	p.E404E	IRF6_uc010psm.1_Silent_p.E309E|IRF6_uc009xct.1_Silent_p.E404E	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	404					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CAGAAAACATCTCGTAGATCA	0.468										HNSCC(57;0.16)			10	30					0	0	0.010729	0	0
KCNH1	3756	broad.mit.edu	37	1	210856679	210856679	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:210856679C>T	uc001hib.2	-	11	3084	c.2914G>A	c.(2914-2916)GAA>AAA	p.E972K	KCNH1_uc001hic.2_Missense_Mutation_p.E945K	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	972	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CTCGATATTTCAAACAACTCC	0.433													5	103					0	0	0.001168	0	0
KCNH1	3756	broad.mit.edu	37	1	210948780	210948781	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:210948780_210948781CC>TT	uc001hib.2	-	10	2191_2192	c.2021_2022GG>AA	c.(2020-2022)CGG>CAA	p.R674Q	KCNH1_uc001hic.2_Missense_Mutation_p.R647Q	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	674	Cytoplasmic (Potential).|cNMP.|Calmodulin-binding.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GCAGGGCATCCCGCTTGATCAC	0.525													6	47					0	0	0.004672	0	0
KCNH1	3756	broad.mit.edu	37	1	211280656	211280656	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:211280656C>T	uc001hib.2	-	2	313	c.143G>A	c.(142-144)GGA>GAA	p.G48E	KCNH1_uc001hic.2_Missense_Mutation_p.G48E	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	48	Cytoplasmic (Potential).|PAS.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CTTGCAAAATCCATCATTGCT	0.393													5	119					0	0	0.001168	0	0
INTS7	25896	broad.mit.edu	37	1	212115266	212115266	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:212115266G>A	uc001hiw.1	-	20	2894	c.2789C>T	c.(2788-2790)TCC>TTC	p.S930F	INTS7_uc009xdb.1_Missense_Mutation_p.S910F|INTS7_uc001hix.1_Missense_Mutation_p.S806F|INTS7_uc001hiy.1_Missense_Mutation_p.S916F|INTS7_uc010pta.1_Missense_Mutation_p.S881F	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	930					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		GTCTTCCAGGGATTTTACAAA	0.453													24	85					0	0	0.014323	0	0
INTS7	25896	broad.mit.edu	37	1	212148585	212148585	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:212148585C>T	uc001hiw.1	-	13	1843	c.1738G>A	c.(1738-1740)GAG>AAG	p.E580K	INTS7_uc009xdb.1_Missense_Mutation_p.E580K|INTS7_uc001hix.1_Missense_Mutation_p.E456K|INTS7_uc001hiy.1_Missense_Mutation_p.E580K|INTS7_uc010pta.1_Missense_Mutation_p.E531K	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	580					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TAATTTTCCTCTTGCAACCCA	0.383													14	74					0	0	0.002450	0	0
FAM71A	149647	broad.mit.edu	37	1	212798400	212798400	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:212798400G>A	uc001hjk.2	+	1	585	c.181G>A	c.(181-183)GAT>AAT	p.D61N	uc010pth.1_Intron	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	61										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		AGAAGTGATTGATGTGCACAA	0.527													30	70					0	0	0.012213	0	0
FAM71A	149647	broad.mit.edu	37	1	212799775	212799775	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:212799775C>T	uc001hjk.2	+	1	1960	c.1556C>T	c.(1555-1557)TCC>TTC	p.S519F	uc010pth.1_RNA	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	519										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		AGTTCCGGTTCCAGCAAGGGA	0.542													15	40					0	0	0.003163	0	0
USH2A	7399	broad.mit.edu	37	1	215847770	215847770	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:215847770G>A	uc001hku.1	-	63	13870	c.13483C>T	c.(13483-13485)CGT>TGT	p.R4495C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4495	Fibronectin type-III 30.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTAAAATCACGATAGCGTGTT	0.458										HNSCC(13;0.011)			13	121					0	0	0.004007	0	0
USH2A	7399	broad.mit.edu	37	1	215848419	215848419	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:215848419G>A	uc001hku.1	-	63	13221	c.12834C>T	c.(12832-12834)CCC>CCT	p.P4278P		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4278	Fibronectin type-III 28.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCAGTTTTTGGGgattcatag	0.363										HNSCC(13;0.011)			14	32					0	0	0.002450	0	0
USH2A	7399	broad.mit.edu	37	1	216073511	216073511	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:216073511G>A	uc001hku.1	-	40	7887	c.7500C>T	c.(7498-7500)CTC>CTT	p.L2500L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2500	Extracellular (Potential).|Fibronectin type-III 11.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTACGGTTGGAGATCACTCA	0.398										HNSCC(13;0.011)			13	29					0	0	0.013537	0	0
SPATA17	128153	broad.mit.edu	37	1	217856677	217856677	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:217856677C>T	uc001hlh.1	+	5	395	c.369C>T	c.(367-369)GTC>GTT	p.V123V	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Silent_p.V123V	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	123						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		ACCTGAAAGTCGTTTCAGAGA	0.348													8	124					0	0	0.003080	0	0
SPATA17	128153	broad.mit.edu	37	1	217947835	217947835	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:217947835C>T	uc001hlh.1	+	7	705	c.679C>T	c.(679-681)CCT>TCT	p.P227S	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.P227S	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	227						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		CCGTTCTTTTCCTCGGTCTGA	0.398													7	41					0	0	0.001984	0	0
SLC30A10	55532	broad.mit.edu	37	1	220089206	220089206	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:220089206G>A	uc001hlw.2	-	4	1254	c.1043C>T	c.(1042-1044)ACC>ATC	p.T348I	SLC30A10_uc001hlu.1_Intron|SLC30A10_uc001hlv.2_Missense_Mutation_p.T103I|SLC30A10_uc001hlx.2_Missense_Mutation_p.T123I	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),	348	Cytoplasmic (Potential).				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		GATGTGCAGGGTGGCAATAAT	0.448													13	79					0	0	0.001855	0	0
EPRS	2058	broad.mit.edu	37	1	220170331	220170331	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:220170331G>A	uc001hly.1	-	18	2805	c.2535C>T	c.(2533-2535)TCC>TCT	p.S845S	EPRS_uc010puf.1_Silent_p.S596S|EPRS_uc001hlz.1_Silent_p.S852S	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	845	WHEP-TRS 2.|3 X 57 AA approximate repeats.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	TGACCTTAGGGGATTTTTCAG	0.388													16	136					0	0	0.004990	0	0
HLX	3142	broad.mit.edu	37	1	221057551	221057551	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:221057551C>T	uc001hmv.3	+	4	1429	c.972C>T	c.(970-972)TTC>TTT	p.F324F		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	324	Homeobox.				cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		AGGTGTGGTTCCAGAACCGGC	0.632													8	56					0	0	0.010729	0	0
DUSP10	11221	broad.mit.edu	37	1	221913028	221913028	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:221913028G>A	uc001hmy.1	-	2	241	c.59C>T	c.(58-60)CCT>CTT	p.P20L	DUSP10_uc001hmx.1_5'Flank|DUSP10_uc001hmz.1_Intron	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	20					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		GAGATCCTGAGGTCGGACGGG	0.532													14	80					0	0	0.002450	0	0
HHIPL2	79802	broad.mit.edu	37	1	222713546	222713546	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:222713546C>T	uc001hnh.1	-	4	1314	c.1256G>A	c.(1255-1257)AGG>AAG	p.R419K		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	419					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CCACATGTTCCTGATCCCATA	0.612													48	503					0	0	0.014410	0	0
MIA3	375056	broad.mit.edu	37	1	222838884	222838884	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:222838884G>A	uc001hnl.2	+	28	5656	c.5647G>A	c.(5647-5649)GGC>AGC	p.G1883S	MIA3_uc001hnm.2_Missense_Mutation_p.G761S	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1883	Pro-rich.|Cytoplasmic (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding	p.G1883G(1)		ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		ACTGCCGTCAGGCTCTAGAGA	0.517													25	302					0	0	0.006320	0	0
DISP1	84976	broad.mit.edu	37	1	223177902	223177902	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:223177902C>T	uc001hnu.1	+	8	3310	c.3163C>T	c.(3163-3165)CAT>TAT	p.H1055Y		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1055	Helical; (Potential).				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		CTTTGCCGTCCATTATGGGGT	0.562													43	550					0	0	0.009718	0	0
TLR5	7100	broad.mit.edu	37	1	223285526	223285526	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:223285526G>A	uc001hnv.1	-	4	1294	c.848C>T	c.(847-849)GCT>GTT	p.A283V	TLR5_uc001hnw.1_Missense_Mutation_p.A283V	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	283	Extracellular (Potential).				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		GGCCAGGCCAGCAAATGTGTT	0.483													13	44					0	0	0.013537	0	0
SUSD4	55061	broad.mit.edu	37	1	223465899	223465899	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:223465899G>A	uc001hnx.2	-	2	877	c.243C>T	c.(241-243)GCC>GCT	p.A81A	SUSD4_uc001hny.3_Silent_p.A81A|SUSD4_uc010puw.1_5'UTR|SUSD4_uc001hnz.2_Silent_p.A81A|SUSD4_uc010pux.1_Intron	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	81	Sushi 1.|Extracellular (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)		AGTGAAATCGGGCTACAGAGC	0.507													31	61					0	0	0.010818	0	0
ACBD3	64746	broad.mit.edu	37	1	226334326	226334326	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:226334326G>A	uc001hpy.2	-	8	1619	c.1572C>T	c.(1570-1572)GTC>GTT	p.V524V		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	524	GOLD.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		TAGTATAATAGACTCTGTAGT	0.388													5	47					0	0	0.001168	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227300563	227300563	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:227300563C>T	uc001hqr.2	-	13	2642	c.1699G>A	c.(1699-1701)GAC>AAC	p.D567N	CDC42BPA_uc001hqs.2_Intron|CDC42BPA_uc009xes.2_Missense_Mutation_p.D567N|CDC42BPA_uc010pvs.1_Missense_Mutation_p.D567N	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	567	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				CAGTGTGCGTCTTTCAGCTCT	0.423													9	139					0	0	0.006214	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227387341	227387341	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:227387341G>A	uc001hqr.2	-	4	1310	c.367C>T	c.(367-369)CGT>TGT	p.R123C	CDC42BPA_uc001hqs.2_Missense_Mutation_p.R123C|CDC42BPA_uc009xes.2_Missense_Mutation_p.R123C|CDC42BPA_uc010pvs.1_Missense_Mutation_p.R123C	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	123	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				CTTTCTTCACGAAAACATGCT	0.284													5	58					0	0	0.001168	0	0
GUK1	2987	broad.mit.edu	37	1	228334616	228334616	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:228334616C>T	uc001hsh.2	+	5	531	c.228C>T	c.(226-228)TTC>TTT	p.F76F	GUK1_uc001hsi.2_Silent_p.F97F|GUK1_uc001hsj.2_Silent_p.F16F|GUK1_uc010pvv.1_Silent_p.F76F|GJC2_uc001hsk.2_5'Flank	NM_000858	NP_000849	Q16774	KGUA_HUMAN	guanylate kinase 1 isoform b	76	Guanylate kinase-like.				nucleobase, nucleoside and nucleotide interconversion|purine nucleotide metabolic process	cytosol	ATP binding|guanylate kinase activity				0		Prostate(94;0.0405)				ATGCCGAGTTCTCGGGGAACC	0.607													10	63					0	0	0.010729	0	0
OBSCN	84033	broad.mit.edu	37	1	228434376	228434376	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:228434376C>T	uc009xez.1	+	13	3949	c.3905C>T	c.(3904-3906)TCG>TTG	p.S1302L	OBSCN_uc001hsn.2_Missense_Mutation_p.S1302L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1302	Poly-Ser.|Ig-like 13.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGCTCCAGTTCGAAAGTGCGC	0.647													27	77					0	0	0.003954	0	0
OBSCN	84033	broad.mit.edu	37	1	228444558	228444558	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:228444558C>T	uc009xez.1	+	15	4560	c.4516C>T	c.(4516-4518)CAG>TAG	p.Q1506*	OBSCN_uc001hsn.2_Nonsense_Mutation_p.Q1506*	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1506	Ig-like 15.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCAGGCGGGCCAGGCGGTCGC	0.647													5	37					0	0	0.000602	0	0
TAF5L	27097	broad.mit.edu	37	1	229738452	229738452	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:229738452C>G	uc001htq.2	-	4	628	c.462G>C	c.(460-462)AAG>AAC	p.K154N	TAF5L_uc001htr.2_Missense_Mutation_p.K154N	NM_014409	NP_055224	O75529	TAF5L_HUMAN	PCAF associated factor 65 beta isoform a	154					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				ATGCTCGAAGCTTGAAGTTAG	0.473													14	103					0	0	0.003163	0	0
URB2	9816	broad.mit.edu	37	1	229773807	229773807	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:229773807C>T	uc001hts.1	+	4	3583	c.3447C>T	c.(3445-3447)TCC>TCT	p.S1149S	URB2_uc009xfd.1_Silent_p.S1149S	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1149						nucleolus				central_nervous_system(2)|ovary(1)	3						CGCTGCTCTCCCATGTTGCCC	0.557													4	48					0	0	0.009096	0	0
CAPN9	10753	broad.mit.edu	37	1	230914722	230914722	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:230914722G>A	uc001htz.1	+	9	1070	c.957G>A	c.(955-957)ATG>ATA	p.M319I	CAPN9_uc009xfg.1_Missense_Mutation_p.M256I|CAPN9_uc001hua.1_Missense_Mutation_p.M293I	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	319	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				GCTGCAGGATGGCATTTAAGG	0.428													6	25					0	0	0.001984	0	0
DISC1	27185	broad.mit.edu	37	1	231906697	231906698	+	Missense_Mutation	DNP	CC	TT	TT	rs150294573	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:231906697_231906698CC>TT	uc001huz.2	+	6	1568_1569	c.1515_1516CC>TT	c.(1513-1518)ACCCCA>ACTTCA	p.P506S	TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.P495S|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.P461S|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.P461S|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.P495S|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.P495S|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwq.1_Missense_Mutation_p.P506S|DISC1_uc010pwr.1_Missense_Mutation_p.P506S|DISC1_uc010pws.1_Missense_Mutation_p.P506S|DISC1_uc010pwt.1_Missense_Mutation_p.P506S|DISC1_uc010pwu.1_Missense_Mutation_p.P156S|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.P506S|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.P506S|DISC1_uc010pxb.1_Missense_Mutation_p.P506S|DISC1_uc010pxc.1_Missense_Mutation_p.P506S|DISC1_uc010pxd.1_Missense_Mutation_p.P151S|DISC1_uc010pxe.1_Missense_Mutation_p.P506S|DISC1_uc009xfr.2_Missense_Mutation_p.P461S|DISC1_uc010pxf.1_Missense_Mutation_p.P506S|DISC1_uc010pxg.1_Missense_Mutation_p.P506S|DISC1_uc010pxh.1_Missense_Mutation_p.P538S|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_Missense_Mutation_p.P151S|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Intron|DISC1_uc010pxn.1_Missense_Mutation_p.P151S|DISC1_uc001hva.2_Missense_Mutation_p.P506S	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	506	Necessary and sufficient for interaction with PCNT and localization at the centrosome.|Interaction with TRAF3IP1.|Required for localization to punctate cytoplasmic foci.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				GCGACCTGACCCCACTGGTGGG	0.594													8	24					0	0	0.004672	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394920	233394920	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:233394920C>T	uc001hvl.2	-	5	923	c.688G>A	c.(688-690)GAA>AAA	p.E230K	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	230						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CCTCCTCTTTCCTTTCCTTTA	0.507													7	104					0	0	0.003080	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367368	234367368	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:234367368C>T	uc001hwa.1	+	2	510	c.282C>T	c.(280-282)TTC>TTT	p.F94F	SLC35F3_uc001hvy.1_Silent_p.F163F	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	94					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TCAGGAAGTTCGACGCGCCCT	0.587													10	125					0	0	0.010729	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367481	234367481	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:234367481G>A	uc001hwa.1	+	2	623	c.395G>A	c.(394-396)CGA>CAA	p.R132Q	SLC35F3_uc001hvy.1_Missense_Mutation_p.R201Q	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	132					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			GTGAAGCAGCGATACAGGTAG	0.597													6	68					0	0	0.001168	0	0
SLC35F3	148641	broad.mit.edu	37	1	234454586	234454586	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:234454586C>T	uc001hwa.1	+	5	1065	c.837C>T	c.(835-837)ATC>ATT	p.I279I	SLC35F3_uc001hvy.1_Silent_p.I348I	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	279	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TCCTCTTCATCACCTGCATTC	0.418													12	136					0	0	0.010729	0	0
TARBP1	6894	broad.mit.edu	37	1	234565931	234565932	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:234565931_234565932GG>AA	uc001hwd.2	-	15	2510_2511	c.2510_2511CC>TT	c.(2509-2511)CCC>CTT	p.P837L		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	837					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			AGCTTTCCAGGGGCCCAGCATG	0.569													7	133					0	0	0.004672	0	0
LYST	1130	broad.mit.edu	37	1	235840451	235840451	+	Missense_Mutation	SNP	G	A	A	rs138111566	by1000genomes	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:235840451G>A	uc001hxj.2	-	50	11153	c.10978C>T	c.(10978-10980)CCT>TCT	p.P3660S	LYST_uc001hxi.2_Missense_Mutation_p.P884S	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3660	WD 5.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GCTGTGACAGGGCTTTTGTGT	0.423									Chediak-Higashi_syndrome				11	77					0	0	0.002450	0	0
LYST	1130	broad.mit.edu	37	1	235884159	235884159	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:235884159T>A	uc001hxj.2	-	40	9537	c.9362A>T	c.(9361-9363)AAT>ATT	p.N3121I	LYST_uc001hxi.2_Missense_Mutation_p.N345I	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3121	BEACH.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTCCAGAAGATTAGGGAGGTT	0.343									Chediak-Higashi_syndrome				8	51					0	0	0.006214	0	0
LYST	1130	broad.mit.edu	37	1	235950643	235950643	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:235950643T>C	uc001hxj.2	-	14	4894	c.4719A>G	c.(4717-4719)AAA>AAG	p.K1573K	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1573					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GTAAAACAGCTTTCATGTCAT	0.383									Chediak-Higashi_syndrome				28	117					0	0	0.006320	0	0
NID1	4811	broad.mit.edu	37	1	236143940	236143940	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:236143940T>A	uc001hxo.2	-	17	3343	c.3241A>T	c.(3241-3243)ACA>TCA	p.T1081S	NID1_uc009xgd.2_Missense_Mutation_p.T948S|NID1_uc009xgc.2_Missense_Mutation_p.T162S	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	1081	LDL-receptor class B 3.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TTCCAGTCTGTCCAGTAAAGG	0.443													6	36					0	0	0.001168	0	0
ACTN2	88	broad.mit.edu	37	1	236889272	236889272	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:236889272G>A	uc001hyf.2	+	5	692	c.488G>A	c.(487-489)AGG>AAG	p.R163K	ACTN2_uc001hyg.2_5'UTR|ACTN2_uc009xgi.1_Missense_Mutation_p.R163K	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	163	CH 2.|Actin-binding.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TGGTGTCAGAGGAAAACTGCT	0.478													11	134					0	0	0.013537	0	0
RYR2	6262	broad.mit.edu	37	1	237870314	237870314	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:237870314G>A	uc001hyl.1	+	68	9766	c.9646G>A	c.(9646-9648)GAA>AAA	p.E3216K	RYR2_uc010pxz.1_Missense_Mutation_p.E171K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3216					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAAACTCATGGAAGAAATCGT	0.428													9	114					0	0	0.006214	0	0
RYR2	6262	broad.mit.edu	37	1	237880638	237880638	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:237880638C>T	uc001hyl.1	+	72	10584	c.10464C>T	c.(10462-10464)CTC>CTT	p.L3488L	RYR2_uc010pxz.1_Silent_p.L443L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3488					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACCAGGAGCTCATTGCTCTGG	0.493													4	21					0	0	0.009096	0	0
FMN2	56776	broad.mit.edu	37	1	240255934	240255934	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:240255934C>T	uc010pyd.1	+	1	750	c.525C>T	c.(523-525)ACC>ACT	p.T175T	FMN2_uc010pye.1_Silent_p.T175T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	175					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GACAAAGGACCAGCTCGGGCT	0.607													6	49					0	0	0.001168	0	0
KMO	8564	broad.mit.edu	37	1	241714300	241714300	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:241714300C>T	uc009xgp.2	+	4	333	c.268C>T	c.(268-270)CTT>TTT	p.L90F	KMO_uc001hyy.2_Missense_Mutation_p.L90F|KMO_uc009xgo.1_Missense_Mutation_p.L90F	NM_003679	NP_003670	O15229	KMO_HUMAN	kynurenine 3-monooxygenase	90					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			ovary(2)	2	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			GATCCACTCTCTTTCAGGAAA	0.398													10	138					0	0	0.008291	0	0
EXO1	9156	broad.mit.edu	37	1	242016659	242016659	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:242016659G>A	uc001hzh.2	+	6	822	c.282_splice	c.e6-1	p.E94_splice	EXO1_uc001hzi.2_Splice_Site_p.E94_splice|EXO1_uc001hzj.2_Splice_Site_p.E94_splice|EXO1_uc009xgq.2_Splice_Site_p.E94_splice	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b						meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			TTCCCTTGCAGAAGACGACAA	0.388								Direct_reversal_of_damage|Editing_and_processing_nucleases					17	60					0	0	0.010504	0	0
MAP1LC3C	440738	broad.mit.edu	37	1	242161914	242161914	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:242161914C>T	uc001hzk.2	-	3	198	c.123G>A	c.(121-123)GTG>GTA	p.V41V		NM_001004343	NP_001004343	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3	41					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GGTAGCGCTCCACTACCACCT	0.552											OREG0014354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	77					0	0	0.002450	0	0
PPPDE1	51029	broad.mit.edu	37	1	244852572	244852572	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:244852572C>T	uc001iao.2	+	3	401	c.137C>T	c.(136-138)CCT>CTT	p.P46L	PPPDE1_uc001iap.2_Intron	NM_016076	NP_057160	Q9BSY9	PPDE1_HUMAN	PPPDE peptidase domain containing 1	46	PPPDE peptidase.									breast(3)	3						GGTGGCCATCCTTACCCCTTT	0.303													14	135					0	0	0.007413	0	0
FAM36A	116228	broad.mit.edu	37	1	245006428	245006428	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:245006428G>A	uc001iar.2	+	4	685	c.307G>A	c.(307-309)GGT>AGT	p.G103S	FAM36A_uc001ias.2_RNA|FAM36A_uc001iat.2_RNA|NCRNA00201_uc001iav.2_RNA	NM_198076	NP_932342	Q5RI15	FA36A_HUMAN	hypothetical protein LOC116228	103						integral to membrane					0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			ATTATATGAAGGTACCCACCT	0.353													18	49					0	0	0.007413	0	0
KIF26B	55083	broad.mit.edu	37	1	245766051	245766051	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:245766051C>T	uc001ibf.1	+	6	1963	c.1523C>T	c.(1522-1524)GCC>GTC	p.A508V	KIF26B_uc010pyq.1_Missense_Mutation_p.A508V|KIF26B_uc001ibg.1_Missense_Mutation_p.A126V	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	508	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AAGATGTTTGCCTTCGATGCA	0.502													18	75					0	0	0.012319	0	0
VN1R5	317705	broad.mit.edu	37	1	247419878	247419878	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:247419878C>T	uc010pyu.1	+	2	505	c.505C>T	c.(505-507)CTT>TTT	p.L169F		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	169	Helical; Name=5; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			AGGATTCTTCCTTTTCTCATG	0.512													9	183					0	0	0.004482	0	0
NLRP3	114548	broad.mit.edu	37	1	247587588	247587588	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:247587588C>T	uc001icr.2	+	5	981	c.843C>T	c.(841-843)CCC>CCT	p.P281P	NLRP3_uc001ics.2_Silent_p.P281P|NLRP3_uc001icu.2_Silent_p.P281P|NLRP3_uc001icw.2_Silent_p.P281P|NLRP3_uc001icv.2_Silent_p.P281P|NLRP3_uc010pyw.1_Silent_p.P279P|NLRP3_uc001ict.1_Silent_p.P279P	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	281	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCTGCTGCCCCGACCCAAACC	0.537													13	38					0	0	0.013537	0	0
OR2C3	81472	broad.mit.edu	37	1	247695169	247695169	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:247695169G>A	uc009xgy.2	-	2	1007	c.645C>T	c.(643-645)ATC>ATT	p.I215I	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			AAGAGACCAGGATGAGCCCCA	0.552													14	26					0	0	0.003163	0	0
C1orf150	148823	broad.mit.edu	37	1	247737610	247737610	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:247737610C>T	uc001idf.2	+	5	379	c.334C>T	c.(334-336)CTT>TTT	p.L112F	C1orf150_uc009xgw.2_RNA|C1orf150_uc001ida.3_RNA|C1orf150_uc001idb.3_RNA|C1orf150_uc009xgx.2_RNA	NM_145278	NP_660321	Q5JQS6	CA150_HUMAN	hypothetical protein LOC148823	112											0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0241)			AGAATATGCCCTTCTTAGGAC	0.443													10	26					0	0	0.008291	0	0
OR2G2	81470	broad.mit.edu	37	1	247751793	247751793	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:247751793G>A	uc010pyy.1	+	1	132	c.132G>A	c.(130-132)GGG>GGA	p.G44G		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTATTTTGGGGAATACCACCA	0.408													11	127					0	0	0.013537	0	0
OR2G2	81470	broad.mit.edu	37	1	247752051	247752052	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:247752051_247752052CC>TT	uc010pyy.1	+	1	390_391	c.390_391CC>TT	c.(388-393)TGCCGT>TGTTGT	p.R131C		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGGCTGTCTGCCGTCCTCTCCA	0.545													18	124					0	0	0.004672	0	0
OR13G1	441933	broad.mit.edu	37	1	247836279	247836279	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:247836279C>T	uc001idi.1	-	1	65	c.65G>A	c.(64-66)GGA>GAA	p.G22E		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GAAGATAATTCCCTGGAGTTC	0.428													9	57					0	0	0.010729	0	0
OR2W3	343171	broad.mit.edu	37	1	248059536	248059536	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248059536C>T	uc001idp.1	+	3	917	c.648C>T	c.(646-648)CTC>CTT	p.L216L	OR2W3_uc010pzb.1_Silent_p.L216L	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TTATCCTGCTCTCTTACAGCT	0.582													11	99					0	0	0.001855	0	0
OR2L8	391190	broad.mit.edu	37	1	248112255	248112255	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248112255C>T	uc001idt.1	+	1	96	c.96C>T	c.(94-96)TTC>TTT	p.F32F	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TCATTGTTTTCATTTTCCTGA	0.398													9	146					0	0	0.004482	0	0
OR2L8	391190	broad.mit.edu	37	1	248112291	248112291	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248112291G>A	uc001idt.1	+	1	132	c.132G>A	c.(130-132)ATG>ATA	p.M44I	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ACCTGTCCATGATTCTTCTCA	0.413													50	188					0	0	0.014410	0	0
OR2L1P	26247	broad.mit.edu	37	1	248154005	248154005	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248154005G>A	uc001idv.1	+	1	437	c.193G>A	c.(193-195)GGA>AGA	p.G65R	OR2L13_uc001ids.2_Intron	NR_002145				RecName: Full=Olfactory receptor 2L5; AltName: Full=Olfactory receptor OR1-53;												0						GATGATAACAGGATCTTGGAT	0.443													6	53					0	0	0.001168	0	0
OR2L2	26246	broad.mit.edu	37	1	248201829	248201829	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248201829G>A	uc001idw.2	+	1	356	c.260G>A	c.(259-261)GGA>GAA	p.G87E	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			tttctgtatggaaacaagtct	0.308													11	122					0	0	0.010729	0	0
OR2L3	391192	broad.mit.edu	37	1	248224163	248224163	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248224163C>T	uc001idx.1	+	1	180	c.180C>T	c.(178-180)TTC>TTT	p.F60F	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CCATGTATTTCCTACTTAGTC	0.403													21	300					0	0	0.003330	0	0
OR2L3	391192	broad.mit.edu	37	1	248224607	248224607	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248224607T>G	uc001idx.1	+	1	624	c.624T>G	c.(622-624)TTT>TTG	p.F208L	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TTCTCGTGTTTCCCTTCATTG	0.498													4	104					0	0	0.009096	0	0
OR2M5	127059	broad.mit.edu	37	1	248308533	248308533	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248308533C>T	uc010pze.1	+	1	84	c.84C>T	c.(82-84)TTC>TTT	p.F28F		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CCTTCCTCTTCTTTCTGGTCC	0.493													10	215					0	0	0.008291	0	0
OR2M3	127062	broad.mit.edu	37	1	248366744	248366744	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248366744C>T	uc010pzg.1	+	1	375	c.375C>T	c.(373-375)GCC>GCT	p.A125A		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCTACACTGCCATTTGCCACC	0.443													18	174					0	0	0.007413	0	0
OR2T33	391195	broad.mit.edu	37	1	248436183	248436183	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248436183G>A	uc010pzi.1	-	1	934	c.934C>T	c.(934-936)CAG>TAG	p.Q312*		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCATTTTGCTGGTGTTTTATG	0.423													12	133					0	0	0.001855	0	0
OR2M7	391196	broad.mit.edu	37	1	248487068	248487068	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248487068G>A	uc010pzk.1	-	1	803	c.803C>T	c.(802-804)CCT>CTT	p.P268L		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTCCTGCATAGGAGAATGATG	0.463													9	68					0	0	0.004482	0	0
OR14C36	127066	broad.mit.edu	37	1	248512664	248512664	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248512664G>A	uc010pzl.1	+	1	588	c.588G>A	c.(586-588)ATG>ATA	p.M196I		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	196	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ATGAGGTCATGATTGTTGTCT	0.493													6	65					0	0	0.001168	0	0
OR2T10	127069	broad.mit.edu	37	1	248756259	248756259	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:248756259C>T	uc010pzn.1	-	1	811	c.811G>A	c.(811-813)GAT>AAT	p.D271N		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GACATCATATCTTTCTCAGGA	0.423													11	34					0	0	0.010729	0	0
FBXO18	84893	broad.mit.edu	37	10	5956154	5956154	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:5956154C>T	uc001iis.2	+	8	1413	c.1318C>T	c.(1318-1320)CAA>TAA	p.Q440*	FBXO18_uc001iir.2_Nonsense_Mutation_p.Q366*|FBXO18_uc009xig.2_Nonsense_Mutation_p.Q366*|FBXO18_uc001iit.2_Nonsense_Mutation_p.Q491*	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	440					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						GAAAACCATCCAACTTACACA	0.408													5	72					0	0	0.001168	0	0
PRKCQ	5588	broad.mit.edu	37	10	6472820	6472820	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:6472820C>T	uc001ijj.1	-	17	1992	c.1917G>A	c.(1915-1917)TGG>TGA	p.W639*	PRKCQ_uc009xim.1_Nonsense_Mutation_p.W576*|PRKCQ_uc001iji.1_Nonsense_Mutation_p.W672*|PRKCQ_uc009xin.1_Nonsense_Mutation_p.W603*|PRKCQ_uc010qax.1_Nonsense_Mutation_p.W514*	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	639	AGC-kinase C-terminal.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						CAAGTTCCTCCCAGTTGATCT	0.597													5	26					0	0	0.000602	0	0
ITIH2	3698	broad.mit.edu	37	10	7759688	7759688	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:7759688G>A	uc001ijs.2	+	6	729	c.567G>A	c.(565-567)AGG>AGA	p.R189R		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	189					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TGAAGTGGAGGAAGCTGGGCT	0.527													10	94					0	0	0.008291	0	0
ITIH2	3698	broad.mit.edu	37	10	7763737	7763737	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:7763737G>A	uc001ijs.2	+	8	1026	c.864G>A	c.(862-864)CTG>CTA	p.L288L		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	288					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						CTGGTGAACTGGAGGTGAGTG	0.537													12	72					0	0	0.001855	0	0
ITIH2	3698	broad.mit.edu	37	10	7772024	7772024	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:7772024G>A	uc001ijs.2	+	12	1551	c.1389G>A	c.(1387-1389)AAG>AAA	p.K463K		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	463	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						ATTTTTTGAAGAGACTGTCCA	0.363													6	65					0	0	0.001984	0	0
TAF3	83860	broad.mit.edu	37	10	8007232	8007232	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:8007232C>T	uc010qbd.1	+	3	1759	c.1759C>T	c.(1759-1761)CCC>TCC	p.P587S		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	587	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						AGAGGCAGATCCCTACAAGTT	0.284													8	77					0	0	0.003080	0	0
ECHDC3	79746	broad.mit.edu	37	10	11805377	11805377	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:11805377C>T	uc001ikw.3	+	5	966	c.746C>T	c.(745-747)TCC>TTC	p.S249F	ECHDC3_uc009xix.2_Missense_Mutation_p.S118F	NM_024693	NP_078969	Q96DC8	ECHD3_HUMAN	enoyl Coenzyme A hydratase domain containing 3	249						mitochondrion	catalytic activity				0						CCGGTGGTGTCCCTGGGCAAA	0.647													6	37					0	0	0.001984	0	0
CCDC3	83643	broad.mit.edu	37	10	12940522	12940522	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:12940522C>T	uc001ilq.1	-	3	841	c.707G>A	c.(706-708)CGC>CAC	p.R236H	CCDC3_uc009xjb.1_RNA|CCDC3_uc001ilr.2_RNA|CCDC3_uc009xjc.1_RNA	NM_031455	NP_113643	Q9BQI4	CCDC3_HUMAN	coiled-coil domain containing 3 precursor	236	Potential.					endoplasmic reticulum|extracellular region				ovary(1)	1		Ovarian(717;0.0822)	BRCA - Breast invasive adenocarcinoma(52;0.163)			CTCCAGGTGGCGGCCCTTCTT	0.682													6	78					0	0	0.003080	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255223	15255223	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:15255223G>A	uc001iob.2	-	8	2371	c.2364C>T	c.(2362-2364)CTC>CTT	p.L788L		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	788	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						CCAGGTACACGAGCTGCGTGT	0.607													8	24					0	0	0.004482	0	0
FAM171A1	221061	broad.mit.edu	37	10	15325960	15325960	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:15325960T>C	uc001iob.2	-	2	249	c.242A>G	c.(241-243)AAG>AGG	p.K81R		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	81	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						ACTGCCCAGCTTATACTGGAA	0.562													4	40					0	0	0.009096	0	0
CUBN	8029	broad.mit.edu	37	10	17085901	17085901	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:17085901C>T	uc001ioo.2	-	26	3806	c.3754G>A	c.(3754-3756)GGA>AGA	p.G1252R		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1252	CUB 7.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGCTGTCTCCACTAGAACGA	0.438													7	90					0	0	0.001984	0	0
CUBN	8029	broad.mit.edu	37	10	17157512	17157512	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:17157512G>A	uc001ioo.2	-	7	730	c.678C>T	c.(676-678)GTC>GTT	p.V226V		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	226					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGATGCCATGGACACAGCGTG	0.542													4	37					0	0	0.000602	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17363164	17363164	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:17363164G>A	uc001ipd.2	-	8	910	c.910C>T	c.(910-912)CTG>TTG	p.L304L	ST8SIA6_uc010qce.1_RNA	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	304	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						AGATCTTTCAGGTACTTGGGA	0.443													17	104					0	0	0.007413	0	0
NSUN6	221078	broad.mit.edu	37	10	18834941	18834941	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:18834941C>A	uc010qcp.1	-	11	1749	c.1331G>T	c.(1330-1332)AGA>ATA	p.R444I	NSUN6_uc001iqb.2_5'Flank	NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	444							methyltransferase activity|RNA binding			ovary(2)	2						CATGTCTTCTCTTCTGGCCTC	0.448													15	119					2.32078e-09	2.51619e-09	0.003163	1	0
PLXDC2	84898	broad.mit.edu	37	10	20466004	20466004	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:20466004G>A	uc001iqg.1	+	8	1597	c.960G>A	c.(958-960)GTG>GTA	p.V320V	PLXDC2_uc001iqh.1_Silent_p.V271V|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	320	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						TTTCGGCTGTGGAGATGACCC	0.328													12	98					0	0	0.001855	0	0
ENKUR	219670	broad.mit.edu	37	10	25288372	25288372	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:25288372C>T	uc001isg.1	-	2	346	c.181G>A	c.(181-183)GAT>AAT	p.D61N	ENKUR_uc001ish.1_Intron	NM_145010	NP_659447	Q8TC29	ENKUR_HUMAN	enkurin	61						cilium|flagellum	calmodulin binding|SH3 domain binding				0						TTTAGGAAATCCTTTGGAGAA	0.323													4	19					0	0	0.009096	0	0
THNSL1	79896	broad.mit.edu	37	10	25314037	25314038	+	Missense_Mutation	DNP	AA	CT	CT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:25314037_25314038AA>CT	uc001isi.3	+	3	2214_2215	c.1885_1886AA>CT	c.(1885-1887)AAC>CTC	p.N629L	ENKUR_uc001ish.1_Intron	NM_024838	NP_079114	Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1	629					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			pancreas(1)	1					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	AGCAGCTATTAACTCCACCTAT	0.436													11	50					0	0	0.004672	0	0
ARMC4	55130	broad.mit.edu	37	10	28224025	28224025	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:28224025C>T	uc009xky.2	-	16	2507	c.2409G>A	c.(2407-2409)GTG>GTA	p.V803V	ARMC4_uc010qds.1_Silent_p.V328V|ARMC4_uc010qdt.1_Silent_p.V495V|ARMC4_uc001itz.2_Silent_p.V803V	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	803							binding			ovary(4)|skin(2)	6						CAAGGAGGTTCACAAGTGGTT	0.458													20	75					0	0	0.014323	0	0
ARMC4	55130	broad.mit.edu	37	10	28284008	28284008	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:28284008C>T	uc009xky.2	-	2	162	c.64G>A	c.(64-66)GAA>AAA	p.E22K	ARMC4_uc001itz.2_Missense_Mutation_p.E22K	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	22							binding			ovary(4)|skin(2)	6						GGGGTGATTTCGAGGATTCCA	0.453													5	45					0	0	0.003080	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315234	30315234	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:30315234G>A	uc001iux.2	-	2	3902	c.3843C>T	c.(3841-3843)TCC>TCT	p.S1281S	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.S1143S|KIAA1462_uc009xle.1_Silent_p.S1281S	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1281										ovary(4)	4						CGTCCTCCTGGGAGTCGGCAT	0.632													7	38					0	0	0.001984	0	0
ZEB1	6935	broad.mit.edu	37	10	31815838	31815838	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:31815838G>A	uc001ivs.3	+	9	3084	c.3021G>A	c.(3019-3021)TCG>TCA	p.S1007S	ZEB1_uc001ivr.3_Silent_p.S789S|ZEB1_uc010qee.1_Silent_p.S789S|ZEB1_uc010qef.1_Silent_p.S789S|ZEB1_uc001ivt.3_Silent_p.S789S|ZEB1_uc001ivu.3_Silent_p.S1008S|ZEB1_uc001ivv.3_Silent_p.S987S|ZEB1_uc010qeh.1_Silent_p.S940S|ZEB1_uc009xlp.2_Silent_p.S991S	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	1007	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				AAATCCTCTCGAATGAGCACG	0.498													5	27					0	0	0.000602	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508709	37508709	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:37508709C>T	uc001iza.1	+	34	4000	c.3901C>T	c.(3901-3903)CTT>TTT	p.L1301F		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1357						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TATTCATTTTCTTGAGAGGAA	0.284													4	11					0	0	0.009096	0	0
ZNF33A	7581	broad.mit.edu	37	10	38344753	38344753	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:38344753C>T	uc001izh.2	+	5	1876	c.1698C>T	c.(1696-1698)ACC>ACT	p.T566T	ZNF33A_uc001izg.2_Silent_p.T567T|ZNF33A_uc010qev.1_Silent_p.T573T|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	566	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						ATAAGTCAACCCTCTCTCAAC	0.398													5	68					0	0	0.001168	0	0
BMS1	9790	broad.mit.edu	37	10	43287155	43287155	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:43287155T>C	uc001jaj.2	+	6	1075	c.717T>C	c.(715-717)ATT>ATC	p.I239I		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	239					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GCCGTTTTATTACAGTTATGA	0.398													12	117					0	0	0.003163	0	0
BMS1	9790	broad.mit.edu	37	10	43312814	43312814	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:43312814G>A	uc001jaj.2	+	15	2810	c.2452G>A	c.(2452-2454)GAA>AAA	p.E818K		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	818					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						CCCCGACGAAGAAGAAAGTGC	0.318													6	12					0	0	0.001168	0	0
OR13A1	79290	broad.mit.edu	37	10	45798916	45798916	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:45798916G>A	uc001jcc.1	-	4	1264	c.955C>T	c.(955-957)CTC>TTC	p.L319F	OR13A1_uc001jcd.1_Missense_Mutation_p.L315F	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	319	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCTTCCTGAGGGCTGCTTTG	0.473													9	71					0	0	0.008291	0	0
ANUBL1	93550	broad.mit.edu	37	10	46121878	46121878	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:46121878T>C	uc001jcp.3	-	7	1635	c.1393A>G	c.(1393-1395)AGT>GGT	p.S465G	ANUBL1_uc001jcl.3_5'UTR|ANUBL1_uc001jcm.3_Missense_Mutation_p.S465G|ANUBL1_uc009xmu.2_Missense_Mutation_p.S391G|ANUBL1_uc001jcn.3_Missense_Mutation_p.S391G|ANUBL1_uc001jco.3_Intron	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	465							zinc ion binding				0						TTGTGAGGACTTAATTCCCGG	0.448													17	139					0	0	0.002780	0	0
PPYR1	5540	broad.mit.edu	37	10	47087077	47087077	+	Silent	SNP	C	T	T	rs148299885	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:47087077C>T	uc001jee.2	+	3	713	c.294C>T	c.(292-294)ACC>ACT	p.T98T	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.T98T	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	98	Helical; Name=2; (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						AGCCGCTGACCGCCGTCTACA	0.567													12	92					0	0	0.010729	0	0
RBP3	5949	broad.mit.edu	37	10	48388700	48388700	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:48388700G>A	uc001jez.2	-	1	2292	c.2178C>T	c.(2176-2178)CTC>CTT	p.L726L		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	726	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	TAAGGTAGGTGAGCTCCTCTG	0.622													5	42					0	0	0.000602	0	0
RBP3	5949	broad.mit.edu	37	10	48388840	48388840	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:48388840C>T	uc001jez.2	-	1	2152	c.2038G>A	c.(2038-2040)GAG>AAG	p.E680K		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	680	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GCCAGAGACTCCAAGTCCACA	0.662													4	35					0	0	0.009096	0	0
RBP3	5949	broad.mit.edu	37	10	48390628	48390628	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:48390628C>T	uc001jez.2	-	1	364	c.250G>A	c.(250-252)GAT>AAT	p.D84N		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	84	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	AGGCGAGGATCGTTCAGGGAG	0.617													8	61					0	0	0.006214	0	0
GDF10	2662	broad.mit.edu	37	10	48426663	48426663	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:48426663C>T	uc001jfb.2	-	3	1800	c.1344G>A	c.(1342-1344)ATG>ATA	p.M448I	GDF10_uc009xnp.2_Missense_Mutation_p.M447I	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	448					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						CAAGGGAGTTCATCTTATCGG	0.562											OREG0020165	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	88					0	0	0.006214	0	0
GDF10	2662	broad.mit.edu	37	10	48428707	48428707	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:48428707C>T	uc001jfb.2	-	2	1635	c.1179G>A	c.(1177-1179)TGG>TGA	p.W393*	GDF10_uc009xnp.2_Nonsense_Mutation_p.W392*|GDF10_uc009xnq.1_Nonsense_Mutation_p.W393*	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	393					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						GTGAGATTATCCATTCATTCC	0.522													5	39					0	0	0.001984	0	0
GDF10	2662	broad.mit.edu	37	10	48429372	48429372	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:48429372G>A	uc001jfb.2	-	2	970	c.514C>T	c.(514-516)CTG>TTG	p.L172L	GDF10_uc009xnp.2_Silent_p.L171L|GDF10_uc009xnq.1_Silent_p.L172L	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	172					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						CGGAAGAGCAGGTGCTGGCGT	0.741													6	40					0	0	0.004482	0	0
FRMPD2	143162	broad.mit.edu	37	10	49386156	49386156	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:49386156G>A	uc001jgi.2	-	22	2936	c.2829C>T	c.(2827-2829)ATC>ATT	p.I943I	FRMPD2_uc001jgh.2_Silent_p.I911I|FRMPD2_uc001jgj.2_Silent_p.I921I|FRMPD2L1_uc001jgf.2_5'Flank|FRMPD2_uc001jgg.2_5'Flank|FRMPD2_uc001jgk.2_5'UTR	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	943					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CACCAGCACTGATTTCTGGAG	0.408													5	19					0	0	0.001168	0	0
FRMPD2	143162	broad.mit.edu	37	10	49444536	49444536	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:49444536C>T	uc001jgi.2	-	9	1089	c.982G>A	c.(982-984)GGA>AGA	p.G328R	FRMPD2_uc001jgh.2_Missense_Mutation_p.G297R|FRMPD2_uc001jgj.2_Missense_Mutation_p.G306R	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	328					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		ACAACCGATCCCGGCAGATGT	0.552													4	40					0	0	0.009096	0	0
C10orf71	118461	broad.mit.edu	37	10	50531167	50531167	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:50531167C>T	uc010qgp.1	+	3	916	c.577C>T	c.(577-579)CTG>TTG	p.L193L		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	193											0						TTCTGCCTTTCTGACAGTCAG	0.542													4	25					0	0	0.001168	0	0
OGDHL	55753	broad.mit.edu	37	10	50953439	50953439	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:50953439T>C	uc001jie.2	-	12	1722	c.1580A>G	c.(1579-1581)TAC>TGC	p.Y527C	OGDHL_uc009xog.2_Missense_Mutation_p.Y554C|OGDHL_uc010qgt.1_Missense_Mutation_p.Y470C|OGDHL_uc010qgu.1_Missense_Mutation_p.Y318C|OGDHL_uc009xoh.2_Missense_Mutation_p.Y318C	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	527					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						CTTGTCTGCGTACTTCTTCAG	0.602													4	28					0	0	0.009096	0	0
AGAP7	653268	broad.mit.edu	37	10	51464844	51464844	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:51464844C>T	uc001jio.2	-	7	1738	c.1612G>A	c.(1612-1614)GAA>AAA	p.E538K	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron	NM_001077685	NP_001071153	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	538	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						TCCTTCTCTTCCCTCGTGGAC	0.567													14	206					0	0	0.004990	0	0
ASAH2	56624	broad.mit.edu	37	10	52005073	52005073	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:52005073G>A	uc001jjd.2	-	2	269	c.269C>T	c.(268-270)ACC>ATC	p.T90I	ASAH2_uc009xos.2_Missense_Mutation_p.T90I	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	90	Lumenal (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						AGACTCTGGGGTTAAAGGCAC	0.537													27	114					0	0	0.003954	0	0
A1CF	29974	broad.mit.edu	37	10	52569699	52569699	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:52569699C>T	uc001jjj.2	-	12	1776	c.1588G>A	c.(1588-1590)GAT>AAT	p.D530N	A1CF_uc010qhn.1_Missense_Mutation_p.D530N|A1CF_uc001jji.2_Missense_Mutation_p.D522N|A1CF_uc001jjh.2_Missense_Mutation_p.D530N|A1CF_uc010qho.1_Missense_Mutation_p.D538N|A1CF_uc009xov.2_Missense_Mutation_p.D522N	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	530					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						ATGGTGCCATCGCCTCCATCA	0.468													7	47					0	0	0.003080	0	0
CSTF2T	23283	broad.mit.edu	37	10	53458049	53458049	+	Missense_Mutation	SNP	G	A	A	rs144891671		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:53458049G>A	uc001jjp.2	-	1	1307	c.1261C>T	c.(1261-1263)CGT>TGT	p.R421C	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	421	9 X 5 AA tandem repeats of M-E-T-R-[AG].|Gly-rich.|1-1.				mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		TCCATGGCACGAGTCTCCATC	0.527													13	78					0	0	0.013537	0	0
PRKG1	5592	broad.mit.edu	37	10	54040623	54040623	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:54040623A>T	uc001jjm.2	+	13	1627	c.1433A>T	c.(1432-1434)AAA>ATA	p.K478I	PRKG1_uc001jjo.2_Missense_Mutation_p.K493I|PRKG1_uc009xow.1_Missense_Mutation_p.K196I|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	478	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		CTGCATTCCAAAGGAATCATT	0.433													6	59					0	0	0.001168	0	0
PCDH15	65217	broad.mit.edu	37	10	55698693	55698693	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:55698693G>A	uc001jju.1	-	25	3650	c.3255C>T	c.(3253-3255)ATC>ATT	p.I1085I	PCDH15_uc010qhq.1_Silent_p.I1090I|PCDH15_uc010qhr.1_Silent_p.I1085I|PCDH15_uc010qhs.1_Silent_p.I1097I|PCDH15_uc010qht.1_Silent_p.I1092I|PCDH15_uc010qhu.1_Silent_p.I1085I|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Silent_p.I1085I|PCDH15_uc010qhw.1_Silent_p.I1048I|PCDH15_uc010qhx.1_Silent_p.I1014I|PCDH15_uc010qhy.1_Silent_p.I1090I|PCDH15_uc010qhz.1_Silent_p.I1085I|PCDH15_uc010qia.1_Silent_p.I1063I|PCDH15_uc010qib.1_Silent_p.I1063I	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1085	Cadherin 10.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TAACACCTGTGATGTTATTAA	0.378										HNSCC(58;0.16)			8	37					0	0	0.004482	0	0
PCDH15	65217	broad.mit.edu	37	10	55955517	55955517	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:55955517C>T	uc001jju.1	-	11	1626	c.1231G>A	c.(1231-1233)GGA>AGA	p.G411R	PCDH15_uc010qhq.1_Missense_Mutation_p.G416R|PCDH15_uc010qhr.1_Missense_Mutation_p.G411R|PCDH15_uc010qhs.1_Missense_Mutation_p.G416R|PCDH15_uc010qht.1_Missense_Mutation_p.G411R|PCDH15_uc010qhu.1_Missense_Mutation_p.G411R|PCDH15_uc001jjv.1_Missense_Mutation_p.G389R|PCDH15_uc010qhv.1_Missense_Mutation_p.G411R|PCDH15_uc010qhw.1_Missense_Mutation_p.G374R|PCDH15_uc010qhx.1_Missense_Mutation_p.G411R|PCDH15_uc010qhy.1_Missense_Mutation_p.G416R|PCDH15_uc010qhz.1_Missense_Mutation_p.G411R|PCDH15_uc010qia.1_Missense_Mutation_p.G389R|PCDH15_uc010qib.1_Missense_Mutation_p.G389R|PCDH15_uc001jjw.2_Missense_Mutation_p.G411R	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	411	Cadherin 4.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATGGTTGCTCCCACTGGGGCA	0.388										HNSCC(58;0.16)			6	55					0	0	0.001168	0	0
BICC1	80114	broad.mit.edu	37	10	60380643	60380643	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:60380643G>A	uc001jki.1	+	2	219	c.219G>A	c.(217-219)GGG>GGA	p.G73G		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	73					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						GCAGAAGTGGGGAAGACTTTT	0.363													4	45					0	0	0.000602	0	0
FAM13C	220965	broad.mit.edu	37	10	61112072	61112072	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:61112072G>A	uc001jkn.2	-	4	416	c.282C>T	c.(280-282)TCC>TCT	p.S94S	FAM13C_uc001jko.2_Silent_p.S94S|FAM13C_uc010qid.1_Silent_p.S11S|FAM13C_uc010qie.1_Silent_p.S11S|FAM13C_uc010qif.1_Silent_p.S116S|FAM13C_uc001jkp.2_Silent_p.S11S	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	94										ovary(2)	2						CTTTGAAGATGGACTTGGGCT	0.577													9	66					0	0	0.006214	0	0
ANK3	288	broad.mit.edu	37	10	61828894	61828894	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:61828894C>T	uc001jky.2	-	37	11937	c.11745G>A	c.(11743-11745)GTG>GTA	p.V3915V	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3915					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTGTGTTTTTCACTGGAATTC	0.418													17	139					0	0	0.004007	0	0
ANK3	288	broad.mit.edu	37	10	61831712	61831712	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:61831712G>A	uc001jky.2	-	37	9119	c.8927C>T	c.(8926-8928)CCC>CTC	p.P2976L	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2976					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						AAAACCATCGGGAATATTAGA	0.453													8	48					0	0	0.006214	0	0
ANK3	288	broad.mit.edu	37	10	61847990	61847990	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:61847990C>T	uc001jky.2	-	29	3647	c.3455G>A	c.(3454-3456)GGA>GAA	p.G1152E	ANK3_uc001jkw.2_Missense_Mutation_p.G286E|ANK3_uc009xpa.2_Missense_Mutation_p.G286E|ANK3_uc001jkx.2_Missense_Mutation_p.G330E|ANK3_uc010qih.1_Missense_Mutation_p.G1153E|ANK3_uc001jkz.3_Missense_Mutation_p.G1146E|ANK3_uc001jla.1_Missense_Mutation_p.G218E|ANK3_uc001jlb.1_Missense_Mutation_p.G670E	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1152					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GCTCAGAATTCCACCTTCAGG	0.468													12	75					0	0	0.001855	0	0
ANK3	288	broad.mit.edu	37	10	62039396	62039396	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:62039396G>A	uc001jky.2	-	2	308	c.116C>T	c.(115-117)TCT>TTT	p.S39F	ANK3_uc010qih.1_Missense_Mutation_p.S22F|ANK3_uc001jkz.3_Missense_Mutation_p.S33F|ANK3_uc001jlb.1_5'UTR	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	39					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						ATTGGCATCAGACTAAAATAA	0.343													7	65					0	0	0.001984	0	0
RTKN2	219790	broad.mit.edu	37	10	64022525	64022525	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:64022525C>T	uc001jlw.2	-	2	213	c.116G>A	c.(115-117)TGG>TAG	p.W39*	ZNF365_uc001jly.3_Intron|RTKN2_uc001jlx.2_Nonsense_Mutation_p.W39*	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	39					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					AAGGAGTTTCCATATTCCTTC	0.353													15	27					0	0	0.003163	0	0
RTKN2	219790	broad.mit.edu	37	10	64022544	64022544	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:64022544G>A	uc001jlw.2	-	2	194	c.97C>T	c.(97-99)CGA>TGA	p.R33*	ZNF365_uc001jly.3_Intron|RTKN2_uc001jlx.2_Nonsense_Mutation_p.R33*	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	33					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					TCTCGCATTCGAATTTCTAAG	0.333													4	28					0	0	0.000602	0	0
JMJD1C	221037	broad.mit.edu	37	10	64975342	64975342	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:64975342G>A	uc001jmn.2	-	6	1093	c.793C>T	c.(793-795)CGT>TGT	p.R265C	JMJD1C_uc001jml.2_Missense_Mutation_p.R46C|JMJD1C_uc001jmm.2_5'UTR|JMJD1C_uc010qiq.1_Missense_Mutation_p.R83C|JMJD1C_uc009xpi.2_Missense_Mutation_p.R83C|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_5'UTR	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	265					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					TGATTGGCACGAGACCTGCGT	0.373													5	48					0	0	0.001984	0	0
JMJD1C	221037	broad.mit.edu	37	10	65140166	65140166	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:65140166A>C	uc001jmn.2	-	2	545	c.245T>G	c.(244-246)TTG>TGG	p.L82W	JMJD1C_uc009xpi.2_5'UTR|JMJD1C_uc001jmr.1_Missense_Mutation_p.L82W	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	82					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GTATTCCACCAAGAAAGTTGA	0.378													3	48					0	0	0.004672	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687059	68687059	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:68687059T>C	uc001jmz.1	+	2	935	c.385T>C	c.(385-387)TTC>CTC	p.F129L	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.F129L	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	129	LRR 3.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TAACAATACCTTCAGACCTGT	0.403													23	80					0	0	0.002780	0	0
CTNNA3	29119	broad.mit.edu	37	10	69366628	69366628	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:69366628T>G	uc009xpn.1	-	3	402	c.279A>C	c.(277-279)GAA>GAC	p.E93D	CTNNA3_uc001jmw.2_Missense_Mutation_p.E93D|CTNNA3_uc001jmx.3_Missense_Mutation_p.E93D|CTNNA3_uc009xpo.1_Missense_Mutation_p.K9T|CTNNA3_uc001jna.2_Missense_Mutation_p.E105D	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	93	Potential.				cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CTTTGCGAACTTCCTCAAGTG	0.418													9	83					0	0	0.004482	0	0
TET1	80312	broad.mit.edu	37	10	70332849	70332849	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:70332849T>G	uc001jok.3	+	2	1259	c.754T>G	c.(754-756)TTT>GTT	p.F252V		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	252					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						GTGTGCTCCTTTTCCCCAAAG	0.458													8	41					0	0	0.003080	0	0
DDX50	79009	broad.mit.edu	37	10	70673321	70673321	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:70673321C>T	uc001jou.2	+	6	1039	c.932C>T	c.(931-933)TCC>TTC	p.S311F	DDX50_uc001jot.2_Missense_Mutation_p.S311F|DDX50_uc010qjc.1_Missense_Mutation_p.S311F	NM_024045	NP_076950	Q9BQ39	DDX50_HUMAN	nucleolar protein GU2	311	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1						ATTCATGAATCCTACAAAACT	0.313													5	31					0	0	0.001168	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72468481	72468481	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:72468481C>T	uc001jrh.2	+	4	817	c.817C>T	c.(817-819)CGC>TGC	p.R273C	ADAMTS14_uc001jrg.2_Missense_Mutation_p.R273C	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	273	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						CTCGGTGGTTCGCTTCCATGG	0.617													12	64					0	0	0.001855	0	0
UNC5B	219699	broad.mit.edu	37	10	73044576	73044576	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:73044576C>T	uc001jro.2	+	3	849	c.404C>T	c.(403-405)TCC>TTC	p.S135F	UNC5B_uc001jrp.2_Missense_Mutation_p.S135F	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	135	Ig-like.|Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						GCCTGGAGCTCCGCGGGCACC	0.677													14	34					0	0	0.003163	0	0
UNC5B	219699	broad.mit.edu	37	10	73050839	73050839	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:73050839C>T	uc001jro.2	+	9	1712	c.1267C>T	c.(1267-1269)CCC>TCC	p.P423S	UNC5B_uc001jrp.2_Missense_Mutation_p.P412S	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	423	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						TGGTTTCCACCCCGTCAACTT	0.592													22	145					0	0	0.002780	0	0
UNC5B	219699	broad.mit.edu	37	10	73051308	73051308	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:73051308C>T	uc001jro.2	+	10	1859	c.1414C>T	c.(1414-1416)CCT>TCT	p.P472S	UNC5B_uc001jrp.2_Missense_Mutation_p.P461S	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	472	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						GACCAACTCTCCTCTGCTGGA	0.642													4	57					0	0	0.000602	0	0
OIT3	170392	broad.mit.edu	37	10	74673144	74673144	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:74673144C>T	uc001jte.1	+	6	1087	c.869C>T	c.(868-870)ACC>ATC	p.T290I	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	290	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					CTCTTCCTGACCAACACCTCC	0.542													10	73					0	0	0.006214	0	0
OIT3	170392	broad.mit.edu	37	10	74684185	74684185	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:74684185C>T	uc001jte.1	+	7	1368	c.1150C>T	c.(1150-1152)CAT>TAT	p.H384Y	OIT3_uc009xqs.1_Intron	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	384	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					GAGCCGAAATCATGGGATCTT	0.517													13	54					0	0	0.013537	0	0
ZMYND17	118490	broad.mit.edu	37	10	75187441	75187441	+	Nonsense_Mutation	SNP	G	A	A	rs145089649		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:75187441G>A	uc001jud.2	-	3	373	c.307C>T	c.(307-309)CGA>TGA	p.R103*	ZMYND17_uc001juc.2_Nonsense_Mutation_p.R103*|ZMYND17_uc009xrh.2_Nonsense_Mutation_p.R126*|ZMYND17_uc009xrg.2_Silent_p.F25F	NM_001024593	NP_001019764	Q4VC12	ZMY17_HUMAN	zinc finger, MYND domain containing 17	103							zinc ion binding			ovary(1)	1	Prostate(51;0.0119)					GCACAGAATCGAAATGTGTCT	0.507													11	96					0	0	0.008291	0	0
USP54	159195	broad.mit.edu	37	10	75302567	75302567	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:75302567G>A	uc001juo.2	-	5	583	c.566C>T	c.(565-567)TCC>TTC	p.S189F	USP54_uc001jum.2_5'Flank|USP54_uc001jun.2_RNA|USP54_uc001jup.2_Missense_Mutation_p.S189F|USP54_uc010qkl.1_Missense_Mutation_p.S189F|USP54_uc001juq.1_5'Flank	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	189					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					TCACCAAAGGGAAGTGGTGGA	0.363													4	23					0	0	0.009096	0	0
KIAA0913	23053	broad.mit.edu	37	10	75550009	75550009	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:75550009G>C	uc009xrl.2	+	7	932	c.900G>C	c.(898-900)AAG>AAC	p.K300N	KIAA0913_uc001jve.2_Missense_Mutation_p.K300N|KIAA0913_uc001jvf.2_Missense_Mutation_p.K300N|KIAA0913_uc001jvh.2_5'Flank|KIAA0913_uc001jvi.2_5'Flank|KIAA0913_uc010qkr.1_5'Flank|KIAA0913_uc001jvj.2_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	300							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					ACATCAAAAAGACACTGCACA	0.552													10	89					0	0	0.006214	0	0
ZCCHC24	219654	broad.mit.edu	37	10	81192458	81192458	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:81192458G>A	uc001kak.2	-	2	490	c.303C>T	c.(301-303)ATC>ATT	p.I101I	ZCCHC24_uc010qlr.1_Missense_Mutation_p.R42C|ZCCHC24_uc009xrw.2_RNA	NM_153367	NP_699198	Q8N2G6	ZCH24_HUMAN	zinc finger, CCHC domain containing 24	101							nucleic acid binding|zinc ion binding			breast(1)	1						GGCCATCGGCGATGTTGTTGA	0.617													4	23					0	0	0.009096	0	0
NRG3	10718	broad.mit.edu	37	10	84733607	84733607	+	Missense_Mutation	SNP	G	A	A	rs144817913		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:84733607G>A	uc001kco.2	+	7	1375	c.1348G>A	c.(1348-1350)GGC>AGC	p.G450S	NRG3_uc010qlz.1_Missense_Mutation_p.G449S|NRG3_uc001kcp.2_Missense_Mutation_p.G229S|NRG3_uc001kcq.2_Missense_Mutation_p.G100S|NRG3_uc001kcr.2_Missense_Mutation_p.G100S	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	450	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AAGTTTTGTCGGCCCCCAGTC	0.502													7	48					0	0	0.001984	0	0
GRID1	2894	broad.mit.edu	37	10	87362151	87362151	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:87362151G>A	uc001kdl.1	-	16	3010	c.2909C>T	c.(2908-2910)TCA>TTA	p.S970L	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.S541L|uc001kdk.1_Intron	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	970	Cytoplasmic (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CCCGTTGGGTGACCTGTGTTT	0.667										Multiple Myeloma(13;0.14)			7	54					0	0	0.004482	0	0
LDB3	11155	broad.mit.edu	37	10	88451783	88451783	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:88451783T>C	uc001kdv.2	+	5	843	c.820T>C	c.(820-822)TCC>CCC	p.S274P	LDB3_uc010qml.1_Missense_Mutation_p.S274P|LDB3_uc010qmm.1_Missense_Mutation_p.S342P|LDB3_uc001kdu.2_Missense_Mutation_p.S227P|LDB3_uc009xsz.2_Intron|LDB3_uc001kdr.2_Missense_Mutation_p.S227P|LDB3_uc009xsy.2_Missense_Mutation_p.S342P|LDB3_uc001kds.2_Missense_Mutation_p.S274P|LDB3_uc001kdt.2_RNA	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1	274						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						GCAGTCTCGCTCCTTCCGCAT	0.617													4	29					0	0	0.009096	0	0
MMRN2	79812	broad.mit.edu	37	10	88702993	88702993	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:88702993C>T	uc001kea.2	-	6	1675	c.1548G>A	c.(1546-1548)GAG>GAA	p.E516E	MMRN2_uc010qmn.1_Silent_p.E159E|MMRN2_uc009xtb.2_Silent_p.E473E	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	516						extracellular space				large_intestine(1)	1						CCTGGGTCTCCTCCAGGGCAC	0.667													10	36					0	0	0.010729	0	0
MMRN2	79812	broad.mit.edu	37	10	88703674	88703674	+	Silent	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:88703674A>G	uc001kea.2	-	6	994	c.867T>C	c.(865-867)CTT>CTC	p.L289L	MMRN2_uc010qmn.1_Intron|MMRN2_uc009xtb.2_Silent_p.L246L	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	289						extracellular space				large_intestine(1)	1						ATTTGGCACCAAGCTCCTGGA	0.612													10	28					0	0	0.006214	0	0
LIPF	8513	broad.mit.edu	37	10	90429633	90429633	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:90429633C>T	uc001kfg.1	+	5	628	c.462C>T	c.(460-462)ATC>ATT	p.I154I	LIPF_uc001kfh.1_Silent_p.I131I|LIPF_uc010qmt.1_Silent_p.I164I|LIPF_uc010qmu.1_Silent_p.I121I	NM_004190	NP_004181	P07098	LIPG_HUMAN	lipase, gastric precursor	154					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity				0		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		CAGCCACAATCGACTTCATTG	0.398													12	119					0	0	0.002450	0	0
MYOF	26509	broad.mit.edu	37	10	95147663	95147664	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:95147663_95147664CC>TT	uc001kin.2	-	19	1711_1712	c.1588_1589GG>AA	c.(1588-1590)GGA>AAA	p.G530K	MYOF_uc001kio.2_Missense_Mutation_p.G517K	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	530	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GTAGGCAACTCCTTCCCCCTGA	0.431													7	69					0	0	0.004672	0	0
PDE6C	5146	broad.mit.edu	37	10	95400221	95400221	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:95400221G>A	uc001kiu.3	+	13	1782	c.1644G>A	c.(1642-1644)TGG>TGA	p.W548*		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	548					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				TTACCAGATGGATGTACACTG	0.428													8	74					0	0	0.004482	0	0
PIPSL	266971	broad.mit.edu	37	10	95719960	95719960	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:95719960C>T	uc009xuj.2	-	1	1713	c.1194G>A	c.(1192-1194)AAG>AAA	p.K398K		NR_002319				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						AGGGAATCTTCTTAAATACCG	0.502													9	36					0	0	0.008291	0	0
CYP2C18	1562	broad.mit.edu	37	10	96495040	96495040	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:96495040G>A	uc001kjv.3	+	9	1638	c.1312G>A	c.(1312-1314)GAG>AAG	p.E438K	CYP2C18_uc001kjw.3_Missense_Mutation_p.E379K|CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Intron	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	438					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GTGTATGGGAGAGGGCCTGGC	0.428													5	50					0	0	0.001168	0	0
CYP2C9	1559	broad.mit.edu	37	10	96698474	96698474	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:96698474C>T	uc001kka.3	+	1	60	c.35C>T	c.(34-36)TCA>TTA	p.S12L	CYP2C9_uc009xut.2_Missense_Mutation_p.S12L|CYP2C9_uc001kjz.2_Missense_Mutation_p.S12L	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	12					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	CTCTGTCTCTCATGTTTGCTT	0.473													29	142					0	0	0.008361	0	0
CYP2C9	1559	broad.mit.edu	37	10	96701699	96701699	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:96701699G>A	uc001kka.3	+	2	278	c.253G>A	c.(253-255)GAA>AAA	p.E85K	CYP2C9_uc009xut.2_Missense_Mutation_p.E85K|CYP2C9_uc001kjz.2_Missense_Mutation_p.E85K	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	85					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	AGCAGTGAAGGAAGCCCTGAT	0.473													11	137					0	0	0.010729	0	0
CYP2C9	1559	broad.mit.edu	37	10	96731977	96731977	+	Silent	SNP	C	T	T	rs9332173		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:96731977C>T	uc001kka.3	+	6	961	c.936C>T	c.(934-936)CTC>CTT	p.L312L	CYP2C9_uc009xut.2_Silent_p.L310L	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	312					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	CTCTCCTTCTCCTGCTGAAGC	0.433													12	69					0	0	0.001855	0	0
CYP2C8	1558	broad.mit.edu	37	10	96798741	96798741	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:96798741G>A	uc001kkb.2	-	8	1299	c.1204C>T	c.(1204-1206)CCT>TCT	p.P402S	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.P332S|CYP2C8_uc010qob.1_Missense_Mutation_p.P316S|CYP2C8_uc010qoc.1_Missense_Mutation_p.P300S|CYP2C8_uc010qod.1_3'UTR	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	402					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	TTTGGATTAGGAAATTCTTTG	0.373													6	38					0	0	0.001168	0	0
CYP2C8	1558	broad.mit.edu	37	10	96802823	96802823	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:96802823C>T	uc001kkb.2	-	7	1068	c.973G>A	c.(973-975)GAA>AAA	p.E325K	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.E255K|CYP2C8_uc010qob.1_Missense_Mutation_p.E239K|CYP2C8_uc010qoc.1_Missense_Mutation_p.E223K|CYP2C8_uc010qod.1_Missense_Mutation_p.E239K	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	325					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	TCAATCTCTTCCTGGACTTTA	0.423													5	44					0	0	0.000602	0	0
BLNK	29760	broad.mit.edu	37	10	97983593	97983593	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:97983593G>A	uc001kls.3	-	6	692	c.514C>T	c.(514-516)CTT>TTT	p.L172F	BLNK_uc001kme.3_Missense_Mutation_p.L90F|BLNK_uc001klt.3_Missense_Mutation_p.L86F|BLNK_uc009xvc.2_Intron|BLNK_uc001klu.3_Missense_Mutation_p.L90F|BLNK_uc001klv.3_Intron|BLNK_uc001klw.3_RNA|BLNK_uc001klx.3_Missense_Mutation_p.L172F|BLNK_uc001kly.3_Missense_Mutation_p.L172F|BLNK_uc001klz.3_Intron|BLNK_uc001kma.3_Missense_Mutation_p.L172F|BLNK_uc001kmb.3_Intron|BLNK_uc001kmc.3_RNA|BLNK_uc001kmd.3_Missense_Mutation_p.L90F|BLNK_uc009xvd.2_Intron	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	172	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		TCATCCTCAAGGAGGCCTTTG	0.592													6	76					0	0	0.001168	0	0
SFRP5	6425	broad.mit.edu	37	10	99527511	99527511	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:99527511C>T	uc001kor.3	-	3	880	c.714G>A	c.(712-714)AAG>AAA	p.K238K		NM_003015	NP_003006	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5 precursor	238	NTR.				apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		GCTTGGTGTCCTTGCGCTTCA	0.602													6	53					0	0	0.001984	0	0
LOXL4	84171	broad.mit.edu	37	10	100017476	100017476	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:100017476C>T	uc001kpa.1	-	8	1342	c.1191G>A	c.(1189-1191)CAG>CAA	p.Q397Q		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	397	SRCR 3.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		GGCAACCATTCTGGGACCCTT	0.577													7	70					0	0	0.001984	0	0
HPS1	3257	broad.mit.edu	37	10	100179853	100179853	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:100179853G>A	uc010qpf.1	-	18	2052	c.1806C>T	c.(1804-1806)TTC>TTT	p.F602F	HPS1_uc001kpi.1_Silent_p.F603F|HPS1_uc001kpj.1_Silent_p.F510F|HPS1_uc001kpk.1_Silent_p.F427F	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	602					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		CCCCCTCCTGGAACAGCAGCG	0.592									Hermansky-Pudlak_syndrome				13	109					0	0	0.001855	0	0
HPSE2	60495	broad.mit.edu	37	10	100249954	100249954	+	Splice_Site	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:100249954C>T	uc001kpn.1	-	10	1381	c.1321_splice	c.e10-1	p.D441_splice	HPSE2_uc009xwc.1_Splice_Site_p.D431_splice|HPSE2_uc001kpo.1_Splice_Site_p.D373_splice|HPSE2_uc009xwd.1_Splice_Site_p.D319_splice	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2						carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GCCAGTAGTCCTGAGGAGAAT	0.502													8	50					0	0	0.010729	0	0
SEC31B	25956	broad.mit.edu	37	10	102257867	102257867	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:102257867G>A	uc001krc.1	-	15	1884	c.1782C>T	c.(1780-1782)ATC>ATT	p.I594I	SEC31B_uc010qpo.1_Silent_p.I593I|SEC31B_uc001krd.1_Silent_p.I131I|SEC31B_uc001krf.1_Silent_p.I131I|SEC31B_uc001kre.1_Silent_p.I131I|SEC31B_uc001krg.1_Silent_p.I163I	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	594					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CCTGGGCCAGGATAATGGCAT	0.552													7	52					0	0	0.003080	0	0
HIF1AN	55662	broad.mit.edu	37	10	102304787	102304788	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:102304787_102304788CC>TT	uc001krj.3	+	4	732_733	c.657_658CC>TT	c.(655-660)TTCCCT>TTTTCT	p.P220S		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	220	JmjC.|Interaction with HIF1A.|Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		GCATCTTATTCCCTCCGGATCA	0.455													5	56					0	0	0.004672	0	0
C10orf2	56652	broad.mit.edu	37	10	102748840	102748840	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:102748840C>T	uc001ksf.2	+	1	1548	c.873C>T	c.(871-873)CCC>CCT	p.P291P	MRPL43_uc001kry.1_5'Flank|MRPL43_uc010qpu.1_5'Flank|MRPL43_uc001krz.1_5'Flank|MRPL43_uc001ksa.1_5'Flank|MRPL43_uc001ksb.1_5'Flank|MRPL43_uc001ksd.1_5'Flank|MRPL43_uc001ksc.2_5'Flank|MRPL43_uc001kse.2_5'Flank|C10orf2_uc001ksg.2_Silent_p.P291P|C10orf2_uc001ksi.2_Intron|C10orf2_uc010qpv.1_Intron|C10orf2_uc001ksh.2_Intron	NM_021830	NP_068602	Q96RR1	PEO1_HUMAN	twinkle isoform A	291					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			ovary(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		CCTGCTTACCCCCTGCCTTAC	0.577													11	120					0	0	0.001855	0	0
ELOVL3	83401	broad.mit.edu	37	10	103987396	103987396	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:103987396C>T	uc001kut.2	+	2	278	c.115C>T	c.(115-117)CCC>TCC	p.P39S		NM_152310	NP_689523	Q9HB03	ELOV3_HUMAN	elongation of very long chain fatty acids like	39	Helical; (Potential).				fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			ovary(2)	2		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		AACCTCATTCCCCATAGCCCT	0.542													12	66					0	0	0.013537	0	0
COL17A1	1308	broad.mit.edu	37	10	105800840	105800840	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:105800840G>A	uc001kxr.2	-	39	2853	c.2684C>T	c.(2683-2685)TCG>TTG	p.S895L		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	895	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGACAGGAACGATCCTGGTGG	0.587													11	53					0	0	0.001855	0	0
SORCS3	22986	broad.mit.edu	37	10	106959853	106959853	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:106959853G>A	uc001kyi.1	+	15	2333	c.2106G>A	c.(2104-2106)CAG>CAA	p.Q702Q	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	702	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGGACTATCAGACCTGGCACC	0.527													5	49					0	0	0.000602	0	0
SORCS3	22986	broad.mit.edu	37	10	107012575	107012575	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:107012575C>T	uc001kyi.1	+	23	3375	c.3148C>T	c.(3148-3150)CCT>TCT	p.P1050S	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1050	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TGCCGTGTTTCCTGGTCTCCC	0.512													13	65					0	0	0.002450	0	0
ACSL5	51703	broad.mit.edu	37	10	114169303	114169303	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:114169303G>A	uc001kzs.2	+	7	712	c.571G>A	c.(571-573)GCA>ACA	p.A191T	ACSL5_uc001kzt.2_Missense_Mutation_p.A191T|ACSL5_uc001kzu.2_Missense_Mutation_p.A247T|ACSL5_uc009xxz.2_Missense_Mutation_p.A191T|ACSL5_uc010qrj.1_5'UTR	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	191	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		ACCCCAAAAGGCATTGGTGCT	0.498													15	109					0	0	0.006122	0	0
NRAP	4892	broad.mit.edu	37	10	115370256	115370256	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:115370256T>C	uc001laj.2	-	31	3729	c.3565A>G	c.(3565-3567)ATT>GTT	p.I1189V	NRAP_uc009xyb.2_Intron|NRAP_uc001lak.2_Missense_Mutation_p.I1154V|NRAP_uc001lal.3_Missense_Mutation_p.I1189V	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1189	Nebulin 31.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CTCCCTTCAATCTCTAACGTG	0.418													3	39					0	0	0.006214	0	0
NHLRC2	374354	broad.mit.edu	37	10	115668122	115668122	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:115668122C>T	uc001lax.1	+	11	2220	c.2008C>T	c.(2008-2010)CCT>TCT	p.P670S	NHLRC2_uc001lay.1_RNA	NM_198514	NP_940916	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	670					cell redox homeostasis					ovary(1)	1				Epithelial(162;0.017)|all cancers(201;0.0187)		ACTACAAATTCCTGATGATTG	0.368													6	48					0	0	0.001168	0	0
FAM160B1	57700	broad.mit.edu	37	10	116606378	116606378	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:116606378C>T	uc001lcb.2	+	11	1794	c.1459C>T	c.(1459-1461)CTT>TTT	p.L487F	FAM160B1_uc001lcc.2_Missense_Mutation_p.L487F	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	487										lung(1)	1						TGAGCACATTCTTTACAACTT	0.308													8	38					0	0	0.003080	0	0
ATRNL1	26033	broad.mit.edu	37	10	116930804	116930804	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:116930804T>A	uc001lcg.2	+	8	1488	c.1102T>A	c.(1102-1104)TTT>ATT	p.F368I	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Missense_Mutation_p.F368I|ATRNL1_uc009xyq.2_Silent_p.S338S	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	368	Kelch 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GGAAAACATCTTTATGTATGG	0.199													9	27					0	0	0.004482	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118351308	118351308	+	Silent	SNP	C	T	T	rs142908624	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:118351308C>T	uc001lco.1	+	3	93	c.75C>T	c.(73-75)CTC>CTT	p.L25L	PNLIPRP1_uc001lcp.2_Silent_p.L25L|PNLIPRP1_uc001lcn.2_Silent_p.L25L|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	25					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		ATGAGGACCTCGGGTGCTTTT	0.552													7	80					0	0	0.001984	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122280585	122280585	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:122280585C>T	uc001lev.1	+	5	775	c.423C>T	c.(421-423)AGC>AGT	p.S141S	PPAPDC1A_uc010qtd.1_Silent_p.S141S|PPAPDC1A_uc009xzl.1_Intron|PPAPDC1A_uc001lew.1_Intron|PPAPDC1A_uc001lex.1_Intron|PPAPDC1A_uc001ley.1_Silent_p.S20S	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	141					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		GCCGCAAAAGCTTCCCCAGCA	0.522													5	27					0	0	0.000602	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122280605	122280605	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:122280605C>T	uc001lev.1	+	5	795	c.443C>T	c.(442-444)TCC>TTC	p.S148F	PPAPDC1A_uc010qtd.1_Missense_Mutation_p.S148F|PPAPDC1A_uc009xzl.1_Intron|PPAPDC1A_uc001lew.1_Intron|PPAPDC1A_uc001lex.1_Intron|PPAPDC1A_uc001ley.1_Missense_Mutation_p.S27F	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	148	Helical; (Potential).				phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		ATCCATTCCTCCTGTAAGTTC	0.512													5	28					0	0	0.000602	0	0
TACC2	10579	broad.mit.edu	37	10	123970247	123970247	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:123970247C>T	uc001lfv.2	+	9	6667	c.6307C>T	c.(6307-6309)CCC>TCC	p.P2103S	TACC2_uc001lfw.2_Missense_Mutation_p.P249S|TACC2_uc009xzx.2_Missense_Mutation_p.P2058S|TACC2_uc010qtv.1_Missense_Mutation_p.P2107S|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Missense_Mutation_p.P181S|TACC2_uc001lga.2_Missense_Mutation_p.P181S|TACC2_uc009xzy.2_Missense_Mutation_p.P181S|TACC2_uc001lgb.2_Missense_Mutation_p.P138S|TACC2_uc010qtw.1_Missense_Mutation_p.P198S	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2103						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTCAGGCAATCCCGAGGCCGT	0.552													7	62					0	0	0.003080	0	0
TACC2	10579	broad.mit.edu	37	10	123970533	123970533	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:123970533G>A	uc001lfv.2	+	9	6953	c.6593G>A	c.(6592-6594)GGG>GAG	p.G2198E	TACC2_uc001lfw.2_Missense_Mutation_p.G344E|TACC2_uc009xzx.2_Missense_Mutation_p.G2153E|TACC2_uc010qtv.1_Missense_Mutation_p.G2202E|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Missense_Mutation_p.G276E|TACC2_uc001lga.2_Missense_Mutation_p.G276E|TACC2_uc009xzy.2_Missense_Mutation_p.G276E|TACC2_uc001lgb.2_Missense_Mutation_p.G233E|TACC2_uc010qtw.1_Missense_Mutation_p.G293E	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2198						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCCGCTGTGGGGCCCAAAGCT	0.612													7	39					0	0	0.003080	0	0
DMBT1	1755	broad.mit.edu	37	10	124358543	124358543	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:124358543G>A	uc001lgk.1	+	26	3316	c.3210G>A	c.(3208-3210)TGG>TGA	p.W1070*	DMBT1_uc001lgl.1_Nonsense_Mutation_p.W1060*|DMBT1_uc001lgm.1_Nonsense_Mutation_p.W571*|DMBT1_uc009xzz.1_Nonsense_Mutation_p.W1070*|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Nonsense_Mutation_p.W31*	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1070	SRCR 8.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTTACCTGTGGAGCTGCCCCC	0.587													7	80					0	0	0.001984	0	0
DMBT1	1755	broad.mit.edu	37	10	124380671	124380671	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:124380671G>A	uc001lgk.1	+	41	5102	c.4996G>A	c.(4996-4998)GAT>AAT	p.D1666N	DMBT1_uc001lgl.1_Missense_Mutation_p.D1656N|DMBT1_uc001lgm.1_Missense_Mutation_p.D1038N|DMBT1_uc009xzz.1_Missense_Mutation_p.D1666N|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Missense_Mutation_p.D369N|DMBT1_uc009yac.1_5'UTR	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1666	SRCR 13.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AACCGTGTGTGATGACAGCTG	0.607													39	195					0	0	0.007835	0	0
DMBT1	1755	broad.mit.edu	37	10	124389489	124389489	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:124389489C>T	uc001lgk.1	+	44	5521	c.5415C>T	c.(5413-5415)AAC>AAT	p.N1805N	DMBT1_uc001lgl.1_Silent_p.N1795N|DMBT1_uc001lgm.1_Silent_p.N1177N|DMBT1_uc009xzz.1_Silent_p.N1805N|DMBT1_uc010qtx.1_Silent_p.N525N|DMBT1_uc009yab.1_Silent_p.N508N|DMBT1_uc009yac.1_Silent_p.N99N	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1805	CUB 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATCGCATAAACCTGGGCTTCA	0.498													7	101					0	0	0.004482	0	0
DMBT1	1755	broad.mit.edu	37	10	124402787	124402787	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:124402787C>T	uc001lgk.1	+	53	7221	c.7115C>T	c.(7114-7116)TCC>TTC	p.S2372F	DMBT1_uc001lgl.1_Missense_Mutation_p.S2362F|DMBT1_uc001lgm.1_Missense_Mutation_p.S1744F|DMBT1_uc009xzz.1_Missense_Mutation_p.S2371F|DMBT1_uc010qtx.1_Missense_Mutation_p.S1092F|DMBT1_uc009yab.1_Missense_Mutation_p.S1075F|DMBT1_uc009yac.1_Missense_Mutation_p.S666F	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2372	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GACCCCTCTTCCCGCTGCTAC	0.602													8	59					0	0	0.006214	0	0
C10orf120	399814	broad.mit.edu	37	10	124457458	124457458	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:124457458G>A	uc001lgn.2	-	3	831	c.799C>T	c.(799-801)CTC>TTC	p.L267F		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	267										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				TTTGCGGGGAGGAATGATTTG	0.368													5	59					0	0	0.001168	0	0
C10orf120	399814	broad.mit.edu	37	10	124459229	124459229	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:124459229C>T	uc001lgn.2	-	1	110	c.78G>A	c.(76-78)AAG>AAA	p.K26K		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	26										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				GCTTTTCATTCTTCCTTTCTT	0.448													7	56					0	0	0.001984	0	0
IKZF5	64376	broad.mit.edu	37	10	124753638	124753638	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:124753638C>T	uc001lha.2	-	5	1217	c.918G>A	c.(916-918)CAG>CAA	p.Q306Q	IKZF5_uc001lgz.2_Silent_p.Q144Q	NM_022466	NP_071911	Q9H5V7	IKZF5_HUMAN	zinc finger protein, subfamily 1A, 5	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		GAGAGGAGCTCTGAGGAATAC	0.532													15	69					0	0	0.002450	0	0
CPXM2	119587	broad.mit.edu	37	10	125528156	125528156	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:125528156G>A	uc001lhk.1	-	9	1510	c.1185C>T	c.(1183-1185)TTC>TTT	p.F395F	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	395					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CCTGACACACGAACTGCACCA	0.627													14	83					0	0	0.006122	0	0
CPXM2	119587	broad.mit.edu	37	10	125539706	125539706	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:125539706G>A	uc001lhk.1	-	7	1280	c.955C>T	c.(955-957)CAC>TAC	p.H319Y	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	319					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TTATAATTGTGGTGCTTAAAA	0.403													7	123					0	0	0.004482	0	0
CPXM2	119587	broad.mit.edu	37	10	125539747	125539747	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:125539747C>T	uc001lhk.1	-	7	1239	c.914G>A	c.(913-915)CGG>CAG	p.R305Q	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	305					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CATCTCGTTCCGGCGGTGATA	0.443													21	86					0	0	0.014323	0	0
CHST15	51363	broad.mit.edu	37	10	125805347	125805347	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:125805347G>A	uc001lhl.2	-	1	895	c.382C>T	c.(382-384)CCA>TCA	p.P128S	CHST15_uc001lhm.2_Missense_Mutation_p.P128S|CHST15_uc001lhn.2_Missense_Mutation_p.P128S|CHST15_uc010que.1_Missense_Mutation_p.P128S|CHST15_uc001lho.2_Missense_Mutation_p.P128S	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	128	Lumenal (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						GTGTCACTTGGGTTTTCGCTG	0.438													12	132					0	0	0.002450	0	0
C10orf137	26098	broad.mit.edu	37	10	127426936	127426937	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:127426936_127426937CC>TT	uc001liq.1	+	15	2196_2197	c.1903_1904CC>TT	c.(1903-1905)CCG>TTG	p.P635L	C10orf137_uc001lin.2_Missense_Mutation_p.P601L|C10orf137_uc001lio.1_Missense_Mutation_p.P601L|C10orf137_uc001lip.1_Missense_Mutation_p.P339L|C10orf137_uc001lir.2_Missense_Mutation_p.P129L|C10orf137_uc001lis.1_5'Flank	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	635					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CACTCCAATCCCGTTAAAATAT	0.431													8	55					0	0	0.004672	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133930844	133930844	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:133930844C>T	uc001lkx.3	+	2	399	c.399C>T	c.(397-399)ACC>ACT	p.T133T		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGGTCAAGACCGTGCTGCTGT	0.607													8	74					0	0	0.004482	0	0
LRRC27	80313	broad.mit.edu	37	10	134158054	134158054	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:134158054C>T	uc010quw.1	+	5	648	c.453C>T	c.(451-453)TTC>TTT	p.F151F	LRRC27_uc001llf.2_Silent_p.F151F|LRRC27_uc010quv.1_Silent_p.F151F|LRRC27_uc001llg.2_RNA|LRRC27_uc001lli.2_Silent_p.F151F|LRRC27_uc001llj.2_Silent_p.F89F|LRRC27_uc001llk.3_Silent_p.F24F	NM_030626	NP_085129	Q9C0I9	LRC27_HUMAN	leucine rich repeat containing 27 isoform a	151	LRR 5.									ovary(1)	1		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		CTCTGGAATTCCCTCCTCAGC	0.502													12	55					0	0	0.003163	0	0
Unknown	0	broad.mit.edu	37	10	134646941	134646941	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:134646941G>A	uc010qux.1	-	42	6216	c.6216C>T	c.(6214-6216)TTC>TTT	p.F2072F		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.																		TCCCTTCATCGAACACAGAGA	0.517													11	91					0	0	0.008291	0	0
CYP2E1	1571	broad.mit.edu	37	10	135345137	135345137	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:135345137C>T	uc001lnj.1	+	3	419	c.386C>T	c.(385-387)TCC>TTC	p.S129F	CYP2E1_uc001lnk.1_5'UTR|CYP2E1_uc009ybl.1_Intron|CYP2E1_uc009ybm.1_5'UTR|CYP2E1_uc001lnl.1_5'UTR	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	129					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	CGGCGGTTTTCCCTGACCACC	0.527									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				7	77					0	0	0.003080	0	0
CYP2E1	1571	broad.mit.edu	37	10	135345656	135345656	+	Silent	SNP	C	T	T	rs139133362	by1000genomes	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:135345656C>T	uc001lnj.1	+	4	549	c.516C>T	c.(514-516)ATC>ATT	p.I172I	CYP2E1_uc001lnk.1_Silent_p.I35I|CYP2E1_uc009ybl.1_5'UTR|CYP2E1_uc009ybm.1_Intron|CYP2E1_uc001lnl.1_5'UTR	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	172					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	CCTTCCTCATCGGCTGCGCGC	0.522									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				18	53					0	0	0.008871	0	0
FRG2B	441581	broad.mit.edu	37	10	135440217	135440217	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr10:135440217G>A	uc010qvg.1	-	1	83	c.30C>T	c.(28-30)CTC>CTT	p.L10L		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	10						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		AGGAGCAGTGGAGATCGGGGT	0.498													7	192					0	0	0.003080	0	0
IFITM3	10410	broad.mit.edu	37	11	319853	319853	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:319853G>A	uc001lpa.2	-	2	488	c.387C>T	c.(385-387)TTC>TTT	p.F129F	uc001loz.2_Intron	NM_021034	NP_066362	Q01628	IFM3_HUMAN	interferon-induced transmembrane protein 3	129	Extracellular (Potential).				response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane		p.F129V(1)		central_nervous_system(7)	7		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CATAGGCCTGGAAGATCAGCA	0.587													6	42					0	0	0.004482	0	0
TRPM5	29850	broad.mit.edu	37	11	2438964	2438964	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:2438964C>T	uc001lwm.3	-	7	1011	c.1002G>A	c.(1000-1002)CTG>CTA	p.L334L	TRPM5_uc010qxl.1_Silent_p.L334L|TRPM5_uc009ydn.2_Silent_p.L336L	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	334	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CACCTTTCACCAGCGCCTTCA	0.622													4	41					0	0	0.009096	0	0
C11orf40	143501	broad.mit.edu	37	11	4594648	4594648	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:4594648C>T	uc010qyg.1	-	2	196	c.196G>A	c.(196-198)GAT>AAT	p.D66N		NM_144663	NP_653264	Q8WZ69	CK040_HUMAN	hypothetical protein LOC143501	66										ovary(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;4.28e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		ATGAACACATCCTTATCTAAG	0.433													4	31					0	0	0.009096	0	0
OR52I2	143502	broad.mit.edu	37	11	4608387	4608387	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:4608387C>T	uc010qyh.1	+	1	345	c.345C>T	c.(343-345)TTC>TTT	p.F115F		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	115	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAGCATCTTCTGCTCAGGAG	0.512													10	135					0	0	0.008291	0	0
OR51E1	143503	broad.mit.edu	37	11	4674251	4674251	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:4674251C>T	uc001lzi.3	+	2	639	c.495C>T	c.(493-495)TTC>TTT	p.F165F		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	164	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTCCTGTCTTCATCAAGCAGC	0.552													9	87					0	0	0.008291	0	0
OR52R1	119695	broad.mit.edu	37	11	4825011	4825011	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:4825011C>T	uc010qym.1	-	1	837	c.837G>A	c.(835-837)GGG>GGA	p.G279G		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGAGCCCATTCCCACGACTTA	0.493													4	37					0	0	0.000602	0	0
OR51S1	119692	broad.mit.edu	37	11	4870000	4870000	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:4870000C>T	uc010qyo.1	-	1	439	c.439G>A	c.(439-441)GGT>AGT	p.G147S		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	147	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTAATTACACCATTGGTGAGG	0.552													15	69					0	0	0.002450	0	0
OR51G2	81282	broad.mit.edu	37	11	4936029	4936029	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:4936029G>A	uc001lzr.1	-	1	865	c.865C>T	c.(865-867)CCT>TCT	p.P289S		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCACAGGAGGAAAGAGAAGA	0.493													5	26					0	0	0.000602	0	0
MMP26	56547	broad.mit.edu	37	11	5010967	5010967	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:5010967G>A	uc001lzv.2	+	2	207	c.189G>A	c.(187-189)CGG>CGA	p.R63R		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	63					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		AATTCCATCGGAATGGGACAG	0.522													6	31					0	0	0.001984	0	0
HBD	3045	broad.mit.edu	37	11	5255235	5255235	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:5255235G>A	uc001maf.1	-	2	496	c.301C>T	c.(301-303)CCT>TCT	p.P101S		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	101					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAGTTCTCAGGATCCACGTGC	0.478													13	51					0	0	0.003163	0	0
OR51B4	79339	broad.mit.edu	37	11	5322391	5322391	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:5322391C>T	uc010qza.1	-	1	786	c.786G>A	c.(784-786)GGG>GGA	p.G262G	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033179	NP_149419	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G262G(1)		pancreas(1)|skin(1)	2		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGCATGTTTCCCAAACCTGT	0.423													5	45					0	0	0.001984	0	0
OR51B2	79345	broad.mit.edu	37	11	5345148	5345148	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:5345148G>A	uc001mao.1	-	1	435	c.380C>T	c.(379-381)CCT>CTT	p.P127L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATATCTCAAAGGATTGCGGAT	0.448													3	31					0	0	0.004672	0	0
OR51B2	79345	broad.mit.edu	37	11	5345273	5345273	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:5345273C>T	uc001mao.1	-	1	310	c.255G>A	c.(253-255)GTG>GTA	p.V85V	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCTGTGATTCACCCATAGGA	0.502													13	34					0	0	0.013537	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443584	5443584	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:5443584C>T	uc010qzd.1	+	1	154	c.154C>T	c.(154-156)CGC>TGC	p.R52C	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACTGTCATTCGCACAGAGCC	0.562													28	117					0	0	0.003755	0	0
OR51I1	390063	broad.mit.edu	37	11	5462117	5462117	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:5462117C>T	uc010qze.1	-	1	628	c.628G>A	c.(628-630)GGT>AGT	p.G210S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGTCCATACCATAGGTAAAA	0.463													3	17					0	0	0.004672	0	0
OR52E6	390078	broad.mit.edu	37	11	5862319	5862319	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:5862319G>A	uc010qzq.1	-	1	809	c.809C>T	c.(808-810)CCC>CTC	p.P270L	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATATATTGGGGAATATCATG	0.413													5	57					0	0	0.000602	0	0
OR52B2	255725	broad.mit.edu	37	11	6190761	6190761	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:6190761A>T	uc010qzy.1	-	1	796	c.796T>A	c.(796-798)TTT>ATT	p.F266I		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTACGCCCAAAATGATGGGTC	0.468													6	38					0	0	0.001168	0	0
OR10A5	144124	broad.mit.edu	37	11	6867807	6867807	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:6867807G>A	uc001met.1	+	1	894	c.894G>A	c.(892-894)GTG>GTA	p.V298V		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATAGCGAGGTGAAGAATGCCC	0.418													16	49					0	0	0.004990	0	0
NLRP14	338323	broad.mit.edu	37	11	7059796	7059796	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:7059796G>A	uc001mfb.1	+	2	303	c.-20_splice	c.e2-1			NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14						cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TCCCCCCACAGAGGCCTGAAT	0.333													8	61					0	0	0.003080	0	0
NLRP14	338323	broad.mit.edu	37	11	7063788	7063788	+	Silent	SNP	G	A	A	rs141888194		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:7063788G>A	uc001mfb.1	+	4	854	c.531G>A	c.(529-531)CAG>CAA	p.Q177Q		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	177	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CACAGCCACAGATCGTGGTGC	0.478													7	45					0	0	0.004482	0	0
OR5P2	120065	broad.mit.edu	37	11	7818247	7818247	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:7818247G>A	uc001mfp.1	-	1	243	c.243C>T	c.(241-243)TTC>TTT	p.F81F		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCTCCACCAGGAAGTTTACAA	0.483													17	75					0	0	0.008871	0	0
NLRP10	338322	broad.mit.edu	37	11	7981498	7981498	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:7981498G>A	uc001mfv.1	-	2	1678	c.1661C>T	c.(1660-1662)TCT>TTT	p.S554F		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	554							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTGCTTCATAGATTCCATCTG	0.388													12	35					0	0	0.001855	0	0
STK33	65975	broad.mit.edu	37	11	8496347	8496347	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:8496347G>A	uc001mgi.1	-	1	1025	c.106C>T	c.(106-108)CCA>TCA	p.P36S	STK33_uc001mgj.1_Missense_Mutation_p.P36S|STK33_uc001mgk.1_Missense_Mutation_p.P36S|STK33_uc010rbn.1_5'UTR|STK33_uc001mgl.3_Intron|STK33_uc009yfp.2_Intron	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	36						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		ACCAAAACTGGAGGAACCCTT	0.373													18	78					0	0	0.008871	0	0
SCUBE2	57758	broad.mit.edu	37	11	9052328	9052328	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:9052328G>A	uc001mhh.1	-	17	2311	c.2231C>T	c.(2230-2232)TCC>TTC	p.S744F	SCUBE2_uc001mhi.1_Missense_Mutation_p.S716F|SCUBE2_uc001mhj.1_Missense_Mutation_p.S618F	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	744						extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		GTCCTGAAAGGAAGTAGCTCC	0.542													23	72					0	0	0.003330	0	0
ZNF143	7702	broad.mit.edu	37	11	9522699	9522699	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:9522699C>T	uc001mhr.2	+	11	1147	c.1029C>T	c.(1027-1029)ATC>ATT	p.I343I	ZNF143_uc009yfu.2_Silent_p.I342I|ZNF143_uc010rby.1_Silent_p.I312I	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	343	C2H2-type 4.				regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		CATCAAATATCAGAAAAGTGC	0.428													12	42					0	0	0.013537	0	0
GALNTL4	374378	broad.mit.edu	37	11	11314705	11314705	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:11314705C>T	uc001mjo.2	-	10	1969	c.1548G>A	c.(1546-1548)GTG>GTA	p.V516V		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	516	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		TCAGAATGCCCACATGGATCT	0.582													6	23					0	0	0.001168	0	0
SOX6	55553	broad.mit.edu	37	11	16340164	16340164	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:16340164G>A	uc001mme.2	-	3	345	c.312C>T	c.(310-312)TCC>TCT	p.S104S	SOX6_uc001mmd.2_Silent_p.S94S|SOX6_uc001mmf.2_Silent_p.S91S|SOX6_uc001mmg.2_Silent_p.S91S|SOX6_uc001mmh.1_RNA|SOX6_uc009ygs.2_RNA|SOX6_uc001mmi.3_Silent_p.S91S|SOX6_uc001mmj.2_Silent_p.S91S	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	91					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						TATTTCGGAAGGAATATAGGG	0.393													8	74					0	0	0.004482	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16847974	16847974	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:16847974G>A	uc001mmo.2	-	10	1051	c.1036C>T	c.(1036-1038)CGT>TGT	p.R346C	PLEKHA7_uc010rcu.1_Missense_Mutation_p.R346C|PLEKHA7_uc001mmn.2_Missense_Mutation_p.R54C	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	346					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						CTCTGGGAACGGTACTGCTCT	0.597													10	38					0	0	0.013537	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16876498	16876498	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:16876498C>T	uc001mmo.2	-	6	475	c.460G>A	c.(460-462)GAC>AAC	p.D154N	PLEKHA7_uc010rcu.1_Missense_Mutation_p.D154N	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	154					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						ATGGCCTGGTCTCTCTTCCCA	0.498													19	46					0	0	0.012319	0	0
SLC6A5	9152	broad.mit.edu	37	11	20625943	20625943	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:20625943C>T	uc001mqd.2	+	3	925	c.652C>T	c.(652-654)CCC>TCC	p.P218S	SLC6A5_uc009yic.2_Intron	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	218	Helical; Name=1; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	CTGGAGGTTTCCCTACCTGGC	0.637													9	111					0	0	0.008291	0	0
SLC6A5	9152	broad.mit.edu	37	11	20652291	20652291	+	Silent	SNP	C	T	T	rs143680068	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:20652291C>T	uc001mqd.2	+	10	1827	c.1554C>T	c.(1552-1554)TTC>TTT	p.F518F	SLC6A5_uc009yic.2_Silent_p.F283F	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	518	Helical; Name=7; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	TTGCCGGCTTCGTCATCTTCT	0.493													17	74					0	0	0.010504	0	0
ANO5	203859	broad.mit.edu	37	11	22261116	22261116	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:22261116G>A	uc001mqi.2	+	9	1081	c.764G>A	c.(763-765)GGC>GAC	p.G255D	ANO5_uc001mqj.2_Missense_Mutation_p.G254D	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	255	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TATCTGCAGGGCCAATATTGG	0.408													28	84					0	0	0.007291	0	0
SLC17A6	57084	broad.mit.edu	37	11	22399265	22399265	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:22399265G>A	uc001mqk.2	+	12	2141	c.1728G>A	c.(1726-1728)AAG>AAA	p.K576K		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	576	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						ATAGCTATAAGGACCGAGTTG	0.353													3	9					0	0	0.004672	0	0
ANO3	63982	broad.mit.edu	37	11	26574872	26574872	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:26574872G>A	uc001mqt.3	+	13	1511	c.1366G>A	c.(1366-1368)GAC>AAC	p.D456N	ANO3_uc010rdr.1_Missense_Mutation_p.D440N|ANO3_uc010rds.1_Missense_Mutation_p.D295N|ANO3_uc010rdt.1_Missense_Mutation_p.D310N	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	456	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GAGACTCAACGACAGCTGTAT	0.433													18	99					0	0	0.007413	0	0
Unknown	0	broad.mit.edu	37	11	30938508	30938508	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:30938508C>T	uc001mss.1	-	4		c.464G>A			uc009yjk.1_Missense_Mutation_p.E569K					Homo sapiens mRNA for KIAA1493 protein, partial cds.																		TGTGAAGTTTCCTGCCAGGCA	0.418													6	85					0	0	0.001984	0	0
CCDC73	493860	broad.mit.edu	37	11	32739681	32739681	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:32739681G>A	uc001mtv.2	-	3	192	c.148C>T	c.(148-150)CAT>TAT	p.H50Y	CCDC73_uc001mtw.1_Missense_Mutation_p.H50Y|CCDC73_uc009yjt.2_Missense_Mutation_p.H50Y	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	50										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TCTTCATAATGAATTTCTGCT	0.189													13	86					0	0	0.002450	0	0
QSER1	79832	broad.mit.edu	37	11	32953291	32953291	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:32953291A>G	uc001mty.2	+	4	367	c.100A>G	c.(100-102)ATG>GTG	p.M34V	QSER1_uc001mtz.1_Missense_Mutation_p.M34V|QSER1_uc001mua.2_5'Flank	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	34										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					CTTCATAGGCATGCATTCCTC	0.403													10	53					0	0	0.010729	0	0
LMO2	4005	broad.mit.edu	37	11	33881075	33881075	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:33881075G>A	uc001mve.2	-	3	743	c.304C>T	c.(304-306)CGT>TGT	p.R102C	LMO2_uc001mvc.2_Missense_Mutation_p.R95C|LMO2_uc001mvd.2_Missense_Mutation_p.R95C|LMO2_uc010rel.1_Missense_Mutation_p.R102C|LMO2_uc010rem.1_Missense_Mutation_p.R171C	NM_001142316	NP_001135788	P25791	RBTN2_HUMAN	LIM domain only 2 isoform 2	102	LIM zinc-binding 2.				multicellular organismal development	nucleus	protein binding|zinc ion binding			lung(1)	1						TCATAGGCACGAATCCGCTTG	0.478			T	TRD@	T-ALL								10	25					0	0	0.013537	0	0
RAG2	5897	broad.mit.edu	37	11	36615100	36615100	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:36615100G>A	uc001mwv.3	-	2	807	c.619C>T	c.(619-621)CAT>TAT	p.H207Y	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	207					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				ATAGAGACATGAAAAGATAGC	0.423									Familial_Hemophagocytic_Lymphohistiocytosis				15	49					0	0	0.003163	0	0
TTC17	55761	broad.mit.edu	37	11	43465731	43465732	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:43465731_43465732CC>TT	uc001mxi.2	+	18	2651_2652	c.2637_2638CC>TT	c.(2635-2640)GGCCCC>GGTTCC	p.P880S	TTC17_uc001mxh.2_Missense_Mutation_p.P937S|TTC17_uc010rfj.1_Missense_Mutation_p.P880S|TTC17_uc001mxj.2_Missense_Mutation_p.P707S	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	880							binding			ovary(5)	5						AGATCACTGGCCCCAAGGTGGC	0.396													5	28					0	0	0.004672	0	0
PEX16	9409	broad.mit.edu	37	11	45932504	45932504	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:45932504G>A	uc001nbu.2	-	10	1209	c.897C>T	c.(895-897)ATC>ATT	p.I299I	PEX16_uc001nbt.2_Silent_p.I299I	NM_004813	NP_004804	Q9Y5Y5	PEX16_HUMAN	peroxisomal biogenesis factor 16 isoform 1	299	Interaction with PEX19.|Cytoplasmic (Potential).				ER-dependent peroxisome organization|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein import into peroxisome membrane	endoplasmic reticulum membrane|integral to peroxisomal membrane	protein C-terminus binding			ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.223)		GCAGGAAGAGGATCCTGGCCC	0.632													17	49					0	0	0.008871	0	0
PHF21A	51317	broad.mit.edu	37	11	45955721	45955721	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:45955721G>A	uc001ncc.3	-	18	2465	c.1841C>T	c.(1840-1842)TCC>TTC	p.S614F	PHF21A_uc001ncb.3_Missense_Mutation_p.S568F|PHF21A_uc009ykx.2_Missense_Mutation_p.S568F|PHF21A_uc001nca.1_3'UTR	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	614	Required for transcriptional repression.				blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						CTTCTCCAGGGAGCTGTGCAT	0.562													4	52					0	0	0.000602	0	0
AMBRA1	55626	broad.mit.edu	37	11	46419343	46419343	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:46419343C>T	uc010rgu.1	-	18	3914	c.3554G>A	c.(3553-3555)AGC>AAC	p.S1185N	AMBRA1_uc010rgt.1_3'UTR|AMBRA1_uc009ylc.1_Missense_Mutation_p.S1156N|AMBRA1_uc001ncu.1_Missense_Mutation_p.S1095N|AMBRA1_uc001ncv.2_Missense_Mutation_p.S1188N|AMBRA1_uc001ncw.2_Missense_Mutation_p.S1066N|AMBRA1_uc001ncx.2_Missense_Mutation_p.S1125N	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	1185					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		AATGCGGTGGCTGACGATGAT	0.672													4	28					0	0	0.001168	0	0
ZNF408	79797	broad.mit.edu	37	11	46723068	46723068	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:46723068C>T	uc001nde.1	+	2	402	c.172C>T	c.(172-174)CCC>TCC	p.P58S	ARHGAP1_uc001ndd.2_5'Flank|ARHGAP1_uc009yle.1_5'Flank|ARHGAP1_uc009ylf.1_5'Flank|ZNF408_uc010rgw.1_Missense_Mutation_p.P50S	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	58					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						AAAGAGCCTTCCCCGGGGCTT	0.667													8	44					0	0	0.006214	0	0
CKAP5	9793	broad.mit.edu	37	11	46765780	46765780	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:46765780G>A	uc001ndi.1	-	44	6002	c.5892C>T	c.(5890-5892)TCC>TCT	p.S1964S	CKAP5_uc009ylg.1_Silent_p.S1857S|CKAP5_uc001ndj.1_Silent_p.S1904S|CKAP5_uc001ndh.1_Silent_p.S893S	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1964					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CTGCTGGTTTGGAGAGCAAAG	0.532													6	47					0	0	0.001984	0	0
MADD	8567	broad.mit.edu	37	11	47304127	47304127	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:47304127C>T	uc001ner.1	+	9	1856	c.1665C>T	c.(1663-1665)ATC>ATT	p.I555I	MADD_uc001neq.2_Silent_p.I555I|MADD_uc001nev.1_Silent_p.I555I|MADD_uc001nes.1_Silent_p.I555I|MADD_uc001net.1_Silent_p.I555I|MADD_uc009yln.1_Silent_p.I555I|MADD_uc001neu.1_Silent_p.I555I|MADD_uc001nex.2_Silent_p.I555I|MADD_uc001nez.2_Silent_p.I555I|MADD_uc001new.2_Silent_p.I555I	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	555	dDENN.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		GGGAATGGATCCTTAACCCCA	0.537													5	21					0	0	0.000602	0	0
FNBP4	23360	broad.mit.edu	37	11	47746311	47746312	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:47746311_47746312GG>AA	uc009ylv.2	-	13	2180_2181	c.2027_2028CC>TT	c.(2026-2028)TCC>TTT	p.S676F	FNBP4_uc001ngi.2_5'UTR|FNBP4_uc001ngj.2_Missense_Mutation_p.S583F|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	676										ovary(1)	1						GACCAGAAAAGGATTCTTTACA	0.406													7	34					0	0	0.004672	0	0
OR4B1	119765	broad.mit.edu	37	11	48238598	48238598	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:48238598C>T	uc010rhs.1	+	1	237	c.237C>T	c.(235-237)TTC>TTT	p.F79F		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						CCCCTAAATTCATCATAGACT	0.448													10	110					0	0	0.006214	0	0
OR4X2	119764	broad.mit.edu	37	11	48267270	48267270	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:48267270C>T	uc001ngs.1	+	1	615	c.615C>T	c.(613-615)GTC>GTT	p.V205V		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTTTTGGGGTCCTCTTAGCAT	0.527													13	70					0	0	0.013537	0	0
OR4C3	256144	broad.mit.edu	37	11	48347284	48347284	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:48347284C>T	uc010rhv.1	+	1	792	c.792C>T	c.(790-792)ACC>ACT	p.T264T		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	237	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CCCTCTCCACCTGTGGAGCCC	0.458													7	67					0	0	0.001984	0	0
OR4A15	81328	broad.mit.edu	37	11	55135936	55135936	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:55135936C>T	uc010rif.1	+	1	577	c.577C>T	c.(577-579)CAG>TAG	p.Q193*		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTTTATTTATCAGCTCCCTTT	0.428													8	85					0	0	0.010729	0	0
OR4C15	81309	broad.mit.edu	37	11	55322305	55322305	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:55322305C>T	uc010rig.1	+	1	523	c.523C>T	c.(523-525)CGT>TGT	p.R175C		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGCCTATGATCGTTATGTGGC	0.507										HNSCC(20;0.049)			10	71					0	0	0.013537	0	0
OR4C11	219429	broad.mit.edu	37	11	55371656	55371656	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:55371656G>A	uc010rii.1	-	1	194	c.194C>T	c.(193-195)TCC>TTC	p.S65F		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCTGCAAAGGACAAATAAAA	0.403													17	62					0	0	0.006122	0	0
OR4P4	81300	broad.mit.edu	37	11	55406375	55406375	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:55406375C>T	uc010rij.1	+	1	542	c.542C>T	c.(541-543)CCT>CTT	p.P181L		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GATGTGTATCCTTTGCTGAAA	0.388													9	45					0	0	0.006214	0	0
OR4S2	219431	broad.mit.edu	37	11	55418704	55418704	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:55418704G>A	uc001nhs.1	+	1	325	c.325G>A	c.(325-327)GAG>AAG	p.E109K		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				TGGTTGCACTGAGATCTTCAT	0.418													11	109					0	0	0.008291	0	0
OR4C6	219432	broad.mit.edu	37	11	55432969	55432969	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:55432969G>A	uc001nht.3	+	3	592	c.327G>A	c.(325-327)GGG>GGA	p.G109G	OR4C6_uc010rik.1_Silent_p.G109G	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GTGGTGTGGGGATCATCCTCC	0.547													16	32					0	0	0.004007	0	0
OR5L1	219437	broad.mit.edu	37	11	55579077	55579077	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:55579077G>A	uc001nhw.1	+	1	135	c.135G>A	c.(133-135)ATG>ATA	p.M45I		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				ACCTGGGCATGATTGCACTGA	0.488													12	169					0	0	0.010729	0	0
OR5D18	219438	broad.mit.edu	37	11	55587575	55587575	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:55587575C>T	uc010rin.1	+	1	470	c.470C>T	c.(469-471)TCC>TTC	p.S157F		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GTCTCATGTTCCTTGGAACTG	0.468													26	76					0	0	0.003954	0	0
OR5T2	219464	broad.mit.edu	37	11	55999927	55999927	+	Silent	SNP	G	A	A	rs138680983	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:55999927G>A	uc010rjc.1	-	1	735	c.735C>T	c.(733-735)ATC>ATT	p.I245I		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	245	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGACCAGCTCGATAGAGCCCA	0.428													6	66					0	0	0.001168	0	0
OR8J1	219477	broad.mit.edu	37	11	56128604	56128604	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:56128604G>A	uc010rjh.1	+	1	882	c.882G>A	c.(880-882)AGG>AGA	p.R294R		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ACAGCCTGAGGAATAAGGATG	0.393													6	42					0	0	0.001168	0	0
PRG2	5553	broad.mit.edu	37	11	57156616	57156616	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:57156616G>A	uc001njz.2	-	2	260	c.233C>T	c.(232-234)TCA>TTA	p.S78L	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.S78L|PRG2_uc001nkb.2_Missense_Mutation_p.S78L|PRG2_uc001nkd.2_Missense_Mutation_p.S78L|PRG2_uc001nkc.2_Missense_Mutation_p.S78L|PRG2_uc001nke.2_Missense_Mutation_p.S358L	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	78					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	ATCTGGCACTGAGATAGACTC	0.557													11	87					0	0	0.013537	0	0
SERPING1	710	broad.mit.edu	37	11	57369590	57369590	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:57369590G>A	uc001nkp.1	+	4	824	c.633G>A	c.(631-633)AAG>AAA	p.K211K	SERPING1_uc001nkq.1_Silent_p.K211K|SERPING1_uc010rju.1_Silent_p.K159K|SERPING1_uc010rjv.1_Silent_p.K216K|SERPING1_uc001nkr.1_Silent_p.K211K|SERPING1_uc009ymi.1_Silent_p.K211K|SERPING1_uc009ymj.1_Silent_p.K211K|SERPING1_uc001nks.1_5'UTR	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	211					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						AGGCCCTGAAGGGCTTCACGA	0.577									Hereditary_Angioedema				10	35					0	0	0.008291	0	0
OR9I1	219954	broad.mit.edu	37	11	57886847	57886848	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:57886847_57886848CC>TT	uc001nml.1	-	1	69_70	c.69_70GG>AA	c.(67-72)TTGGAG>TTAAAG	p.E24K	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				AGGGGAATCTCCAATTTGGGGT	0.441													5	35					0	0	0.004672	0	0
OR9Q2	219957	broad.mit.edu	37	11	57958437	57958437	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:57958437C>T	uc010rka.1	+	1	475	c.475C>T	c.(475-477)CGA>TGA	p.R159*		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				TGCCTTTGTTCGAACGGTCAC	0.507													8	29					0	0	0.004482	0	0
LPXN	9404	broad.mit.edu	37	11	58295563	58295563	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:58295563G>A	uc001nmw.2	-	8	989	c.844C>T	c.(844-846)CTT>TTT	p.L282F	LPXN_uc009ymp.2_Missense_Mutation_p.L152F|LPXN_uc010rkj.1_Missense_Mutation_p.L287F|LPXN_uc010rkk.1_Missense_Mutation_p.L262F	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2	282	LIM zinc-binding 3.				cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				ATGGCTGAAAGGTAGTTTTCC	0.473													17	69					0	0	0.010504	0	0
OR5A2	219981	broad.mit.edu	37	11	59189624	59189624	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:59189624G>A	uc010rkt.1	-	1	803	c.803C>T	c.(802-804)TCC>TTC	p.S268F		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTGTTTAGGGAGTAGCTGGA	0.478													7	15					0	0	0.001984	0	0
MS4A5	64232	broad.mit.edu	37	11	60198378	60198378	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:60198378C>T	uc001npo.2	+	2	349	c.263C>T	c.(262-264)CCA>CTA	p.P88L		NM_023945	NP_076434	Q9H3V2	MS4A5_HUMAN	membrane-spanning 4-domains, subfamily A, member	88	Helical; (Potential).					integral to membrane	receptor activity			large_intestine(1)|ovary(1)	2						TCAGGATATCCATTCTGGGGC	0.363													12	52					0	0	0.002450	0	0
DAGLA	747	broad.mit.edu	37	11	61487708	61487708	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:61487708C>T	uc001nsa.2	+	2	192	c.81C>T	c.(79-81)CTC>CTT	p.L27L		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	27	Helical; (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		TCCTCTTTCTCCTGCATACCA	0.627													6	49					0	0	0.003080	0	0
SCGB1D1	10648	broad.mit.edu	37	11	61959585	61959585	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:61959585G>A	uc001nsz.1	+	2	160	c.113G>A	c.(112-114)GGA>GAA	p.G38E		NM_006552	NP_006543	O95968	SG1D1_HUMAN	lipophilin A precursor	38						extracellular space	binding			skin(1)	1						TTATTAGCTGGAAAACCTGTG	0.418													10	34					0	0	0.008291	0	0
AHNAK	79026	broad.mit.edu	37	11	62295588	62295588	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:62295588T>C	uc001ntl.2	-	5	6601	c.6301A>G	c.(6301-6303)AAG>GAG	p.K2101E	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2101					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTGGGGCCCTTCAGCTTCCCT	0.522													18	148					0	0	0.004990	0	0
EML3	256364	broad.mit.edu	37	11	62376026	62376026	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:62376026G>A	uc001ntu.1	-	9	1406	c.1098C>T	c.(1096-1098)GCC>GCT	p.A366A	EML3_uc001ntr.1_Silent_p.A338A|EML3_uc001nts.1_Silent_p.A338A|EML3_uc001ntt.1_Silent_p.A250A|EML3_uc010rly.1_Silent_p.A366A|EML3_uc009yny.1_Silent_p.A149A	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	366	WD 2.					cytoplasm|microtubule	protein binding			ovary(1)	1						CAGCTGAAAAGGCCAGGGCCC	0.602													20	116					0	0	0.010504	0	0
SLC22A9	114571	broad.mit.edu	37	11	63137867	63137867	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:63137867G>A	uc001nww.2	+	1	607	c.339G>A	c.(337-339)ATG>ATA	p.M113I	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	113	Extracellular (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						ACGCAGACATGGAGCCCTGTG	0.522													9	40					0	0	0.006214	0	0
HRASLS5	117245	broad.mit.edu	37	11	63235895	63235895	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:63235895G>A	uc001nwy.2	-	4	592	c.418C>T	c.(418-420)CGA>TGA	p.R140*	HRASLS5_uc001nwz.2_Nonsense_Mutation_p.R130*|HRASLS5_uc010rmq.1_Nonsense_Mutation_p.R140*|HRASLS5_uc009yos.2_Intron	NM_054108	NP_473449	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5 isoform 1	140										ovary(1)	1						TAGCCAATTCGAAAAATCTCA	0.418													10	87					0	0	0.010729	0	0
SLC22A12	116085	broad.mit.edu	37	11	64366372	64366372	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:64366372G>A	uc001oam.1	+	6	1794	c.1047G>A	c.(1045-1047)CGG>CGA	p.R349R	SLC22A12_uc009ypr.1_Silent_p.R374R|SLC22A12_uc001oal.1_Silent_p.R128R|SLC22A12_uc009yps.1_Silent_p.R315R|SLC22A12_uc001oan.1_Silent_p.R241R|SLC22A12_uc009ypt.2_Silent_p.R167R	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	349					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						TGCGCTTCCGGACCTGTATCT	0.667													6	25					0	0	0.001168	0	0
PYGM	5837	broad.mit.edu	37	11	64526175	64526175	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:64526175C>T	uc001oax.3	-	2	1062	c.245G>A	c.(244-246)AGG>AAG	p.R82K	PYGM_uc001oay.3_Intron	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	82					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	GTAGTAGATCCTCTGCCCAGA	0.602													8	32					0	0	0.006214	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64594785	64594785	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:64594785G>A	uc001obs.3	-	33	4236	c.4236C>T	c.(4234-4236)TTC>TTT	p.F1412F		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1412					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						CCGACACGCGGAAAAAGAAGC	0.667													5	48					0	0	0.000602	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64594815	64594815	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:64594815G>A	uc001obs.3	-	33	4206	c.4206C>T	c.(4204-4206)TTC>TTT	p.F1402F		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1402					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						TCTTGGTGCGGAACAGCTGGC	0.652													5	70					0	0	0.001168	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64606563	64606563	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:64606563T>C	uc001obs.3	-	7	818	c.818A>G	c.(817-819)GAG>GGG	p.E273G		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	273	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						GAAGGGCGTCTCCCCAAAGAG	0.607													13	52					0	0	0.002450	0	0
NAALADL1	10004	broad.mit.edu	37	11	64825817	64825817	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:64825817C>T	uc001ocn.2	-	1	193	c.177G>A	c.(175-177)GAG>GAA	p.E59E	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	59	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						ACCTGAGGTTCTCCCGGATCC	0.637													5	27					0	0	0.001168	0	0
ZFPL1	7542	broad.mit.edu	37	11	64853986	64853986	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:64853986T>C	uc001ocq.1	+	4	479	c.314T>C	c.(313-315)TTC>TCC	p.F105S	CDCA5_uc001ocp.2_5'Flank	NM_006782	NP_006773	O95159	ZFPL1_HUMAN	zinc finger protein-like 1	105	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|vesicle-mediated transport	Golgi apparatus|integral to membrane|nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGCCCCATCTTCCCCCCAACC	0.647													20	66					0	0	0.007413	0	0
TIGD3	220359	broad.mit.edu	37	11	65124129	65124129	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:65124129C>T	uc001odo.3	+	2	1013	c.850C>T	c.(850-852)CTC>TTC	p.L284F		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	284	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CCACGTGAAGCTCTTGCCTCT	0.662													13	42					0	0	0.001855	0	0
FIBP	9158	broad.mit.edu	37	11	65653047	65653047	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:65653047G>A	uc001ogd.2	-	5	721	c.600C>T	c.(598-600)GCC>GCT	p.A200A	FIBP_uc009yqu.2_Silent_p.A197A|FIBP_uc001oge.2_Silent_p.A200A	NM_198897	NP_942600	O43427	FIBP_HUMAN	FGF intracellular binding protein isoform a	200					fibroblast growth factor receptor signaling pathway	endomembrane system|membrane|microsome|mitochondrion|nucleus	fibroblast growth factor binding			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.166)		CAGCGCAGAAGGCAAAGTCAC	0.562											OREG0021089	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	77					0	0	0.006122	0	0
NPAS4	266743	broad.mit.edu	37	11	66192534	66192534	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:66192534G>A	uc001ohx.1	+	7	2349	c.2173G>A	c.(2173-2175)GAA>AAA	p.E725K	NPAS4_uc010rpc.1_Missense_Mutation_p.E515K	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	725					transcription, DNA-dependent		DNA binding|signal transducer activity				0						TCCCAGTGAGGAATGGGGCTC	0.602													15	51					0	0	0.003163	0	0
CARNS1	57571	broad.mit.edu	37	11	67191319	67191319	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:67191319G>A	uc009yrp.2	+	9	2183	c.1731G>A	c.(1729-1731)CGG>CGA	p.R577R	PPP1CA_uc001okx.1_5'Flank|CARNS1_uc001olc.3_Silent_p.R716R	NM_020811	NP_065862	A5YM72	CRNS1_HUMAN	ATP-grasp domain containing 1	577	ATP-grasp.|ATP (By similarity).				carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding				0						ACTTTTCCCGGATTACCCGAG	0.632													4	22					0	0	0.000602	0	0
LRP5	4041	broad.mit.edu	37	11	68115394	68115394	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:68115394C>T	uc001ont.2	+	2	246	c.171C>T	c.(169-171)ATC>ATT	p.I57I	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	57	Beta-propeller 1.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						AGTCCACCATCGTGGTCAGCG	0.642													12	39					0	0	0.013537	0	0
LRP5	4041	broad.mit.edu	37	11	68201134	68201134	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:68201134G>A	uc001ont.2	+	18	3903	c.3828G>A	c.(3826-3828)GGG>GGA	p.G1276G	LRP5_uc009ysg.2_Silent_p.G686G	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1276	LDL-receptor class A 1.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GTATCCCCGGGGCCTGGCGCT	0.687													29	88					0	0	0.007291	0	0
PPFIA1	8500	broad.mit.edu	37	11	70189920	70189920	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:70189920C>T	uc001opo.2	+	15	2051	c.1853C>T	c.(1852-1854)TCG>TTG	p.S618L	PPFIA1_uc001opn.1_Missense_Mutation_p.S618L|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	618					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			GACCTGCTATCGCCCAGCGGG	0.547													4	19					0	0	0.009096	0	0
ARAP1	116985	broad.mit.edu	37	11	72404460	72404460	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:72404460G>A	uc001osu.2	-	29	4053	c.3864C>T	c.(3862-3864)AGC>AGT	p.S1288S	ARAP1_uc001osv.2_Silent_p.S1288S|ARAP1_uc001osr.2_Silent_p.S1048S|ARAP1_uc001oss.2_Silent_p.S1043S|ARAP1_uc009yth.2_Silent_p.S982S|ARAP1_uc010rre.1_Silent_p.S1043S|uc009yti.1_RNA	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1288	PH 4.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						GGCCCAGGAGGCTGCGGTCCT	0.637													33	348					0	0	0.006999	0	0
ARAP1	116985	broad.mit.edu	37	11	72423547	72423547	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:72423547C>T	uc001osu.2	-	6	1003	c.814G>A	c.(814-816)GAA>AAA	p.E272K	ARAP1_uc001osv.2_Missense_Mutation_p.E272K|ARAP1_uc001osr.2_Missense_Mutation_p.E32K|ARAP1_uc001oss.2_Missense_Mutation_p.E27K|ARAP1_uc009yth.2_Missense_Mutation_p.E27K|ARAP1_uc010rre.1_Missense_Mutation_p.E27K	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	272					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						CCAGACAGTTCCTCTCCCTCG	0.672													23	210					0	0	0.002780	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73073768	73073768	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:73073768C>T	uc001otu.2	+	14	5006	c.4985C>T	c.(4984-4986)TCC>TTC	p.S1662F		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1662					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						ACCATCTCCTCCAGCTTTGGC	0.642													7	36					0	0	0.006214	0	0
RELT	84957	broad.mit.edu	37	11	73101834	73101835	+	Missense_Mutation	DNP	CC	GT	GT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:73101834_73101835CC>GT	uc001otv.2	+	4	320_321	c.155_156CC>GT	c.(154-156)CCC>CGT	p.P52R	RELT_uc001otw.2_Missense_Mutation_p.P52R|RELT_uc009yto.1_5'UTR|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	52	TNFR-Cys.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						AGGCCCTGCCCCCCAGGCACCT	0.668													7	53					0	0	0.004672	0	0
P4HA3	283208	broad.mit.edu	37	11	74009362	74009362	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:74009362C>T	uc001ouz.2	-	4	655	c.612G>A	c.(610-612)CTG>CTA	p.L204L	P4HA3_uc001ouy.3_RNA|P4HA3_uc010rrj.1_Silent_p.L204L	NM_182904	NP_878907	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha III subunit	204						endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			skin(1)	1	Breast(11;2.31e-05)					CAGCCTCCTCCAGCCATGGAA	0.478													29	100					0	0	0.008361	0	0
MAP6	4135	broad.mit.edu	37	11	75319271	75319271	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:75319271G>A	uc001owu.2	-	2	1067	c.1002C>T	c.(1000-1002)ACC>ACT	p.T334T	MAP6_uc001owv.2_Silent_p.T334T	NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	334						Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					CACTGTAGCTGGTCTCATGAA	0.498													7	45					0	0	0.003080	0	0
LRRC32	2615	broad.mit.edu	37	11	76370947	76370947	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:76370947G>A	uc001oxq.3	-	3	1933	c.1690C>T	c.(1690-1692)CGG>TGG	p.R564W	LRRC32_uc001oxr.3_Missense_Mutation_p.R564W|LRRC32_uc010rsf.1_Missense_Mutation_p.R550W	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	564	Extracellular (Potential).					integral to plasma membrane					0						TAGAGGCGCCGGAGGCTGGTC	0.667													5	21					0	0	0.000602	0	0
MYO7A	4647	broad.mit.edu	37	11	76868005	76868005	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:76868005G>A	uc001oyb.2	+	7	962	c.690G>A	c.(688-690)GCG>GCA	p.A230A	MYO7A_uc010rsl.1_Silent_p.A230A|MYO7A_uc010rsm.1_Silent_p.A219A|MYO7A_uc001oyc.2_Silent_p.A230A	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	230	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						TCGAGGGCGCGAAGATTGAGC	0.582													8	42					0	0	0.004482	0	0
MYO7A	4647	broad.mit.edu	37	11	76924939	76924939	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:76924939C>T	uc001oyb.2	+	48	6745	c.6473C>T	c.(6472-6474)TCC>TTC	p.S2158F	MYO7A_uc001oyc.2_Missense_Mutation_p.S2118F|MYO7A_uc001oye.2_RNA	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	2158	FERM 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						ACCAAGATCTCCAACTGGAGC	0.592													6	72					0	0	0.001984	0	0
CCDC81	60494	broad.mit.edu	37	11	86098632	86098632	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:86098632C>T	uc001pbx.1	+	3	644	c.216C>T	c.(214-216)ATC>ATT	p.I72I	CCDC81_uc001pbw.1_Silent_p.I72I	NM_001156474	NP_001149946	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81 isoform 1	72										skin(1)	1		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				ACAAATTTATCTTAATCCAGA	0.363													20	88					0	0	0.008871	0	0
NAALAD2	10003	broad.mit.edu	37	11	89891364	89891364	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:89891364C>T	uc001pdf.3	+	7	957	c.848C>T	c.(847-849)CCT>CTT	p.P283L	NAALAD2_uc009yvx.2_Missense_Mutation_p.P283L|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pdd.2_Missense_Mutation_p.P283L|NAALAD2_uc001pde.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	283	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CCCCGAATACCTGTACATCCC	0.289													28	83					0	0	0.013726	0	0
AMOTL1	154810	broad.mit.edu	37	11	94599213	94599214	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:94599213_94599214CC>AT	uc001pfb.2	+	11	2538_2539	c.2368_2369CC>AT	c.(2368-2370)CCT>ATT	p.P790I	AMOTL1_uc001pfc.2_Missense_Mutation_p.P740I	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	790						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CAGCCTACGTCCTGCCCGCTCC	0.525													6	21					0	0	0.004672	0	0
FAM76B	143684	broad.mit.edu	37	11	95512104	95512104	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:95512104G>A	uc001pfn.2	-	8	1022	c.710C>T	c.(709-711)TCA>TTA	p.S237L	FAM76B_uc001pfm.2_RNA	NM_144664	NP_653265	Q5HYJ3	FA76B_HUMAN	hypothetical protein LOC143684	237											0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ACTATCTGCTGACTGATTTAT	0.348													6	15					0	0	0.001168	0	0
CNTN5	53942	broad.mit.edu	37	11	100221452	100221452	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:100221452G>A	uc001pga.2	+	24	3389	c.3050G>A	c.(3049-3051)GGT>GAT	p.G1017D	CNTN5_uc001pgb.2_Missense_Mutation_p.G943D|CNTN5_uc010ruk.1_Missense_Mutation_p.G288D	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	1017	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGGCAAGAGGGTCACAGCAAC	0.299													10	12					0	0	0.006214	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101762035	101762035	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:101762035C>T	uc001pgl.2	-	9	1738	c.1142G>A	c.(1141-1143)AGA>AAA	p.R381K		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	381	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		ATTGTACATTCTTCTAATTTT	0.289													11	37					0	0	0.001855	0	0
MMP27	64066	broad.mit.edu	37	11	102575311	102575311	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:102575311C>T	uc001phd.1	-	2	321	c.298G>A	c.(298-300)GGC>AGC	p.G100S		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	100					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		AGGGTGTAGCCATACTGGCCC	0.473													16	50					0	0	0.003163	0	0
MMP12	4321	broad.mit.edu	37	11	102734972	102734972	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:102734972C>T	uc001phk.2	-	10	1262	c.1217G>A	c.(1216-1218)AGG>AAG	p.R406K		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	406	Hemopexin-like 3.				positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	CATCTGTCTCCTTTCATCATA	0.438													5	18					0	0	0.000602	0	0
KBTBD3	143879	broad.mit.edu	37	11	105925012	105925012	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:105925012G>A	uc001pja.2	-	4	1044	c.404C>T	c.(403-405)TCC>TTC	p.S135F	KBTBD3_uc001pjb.2_Missense_Mutation_p.S135F|KBTBD3_uc009yxm.2_Missense_Mutation_p.S56F	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	131										ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		GGATAGGAAGGAAACTTGAAG	0.323													3	13					0	0	0.004672	0	0
ALKBH8	91801	broad.mit.edu	37	11	107403073	107403073	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:107403073C>T	uc010rvr.1	-	8	906	c.831G>A	c.(829-831)CGG>CGA	p.R277R	ALKBH8_uc001pjk.2_Silent_p.R25R|ALKBH8_uc010rvq.1_Silent_p.R140R|ALKBH8_uc009yxp.2_Silent_p.R277R|ALKBH8_uc001pjl.2_RNA	NM_138775	NP_620130	Q96BT7	ALKB8_HUMAN	alkB, alkylation repair homolog 8	277	Fe2OG dioxygenase.				response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)		CCAGCAAACTCCGACGAGGCA	0.383													7	22					0	0	0.001984	0	0
LAYN	143903	broad.mit.edu	37	11	111414911	111414911	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:111414911T>C	uc001plr.1	+	3	709	c.373T>C	c.(373-375)TAT>CAT	p.Y125H	LAYN_uc001plp.1_Missense_Mutation_p.Y117H|LAYN_uc001plq.1_Missense_Mutation_p.Y125H|LAYN_uc001pls.1_Missense_Mutation_p.Y117H|LAYN_uc010rwg.1_Silent_p.F24F|LAYN_uc010rwh.1_5'UTR	NM_178834	NP_849156	Q6UX15	LAYN_HUMAN	layilin	125	C-type lectin.|Extracellular (Potential).					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding				0		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		CCAGGACCTTTATGCTTGGAC	0.473													9	18					0	0	0.006214	0	0
PPP2R1B	5519	broad.mit.edu	37	11	111636043	111636044	+	Missense_Mutation	DNP	TC	GT	GT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:111636043_111636044TC>GT	uc001plx.1	-	2	263_264	c.179_180GA>AC	c.(178-180)CGA>CAC	p.R60H	PPP2R1B_uc001plw.1_Missense_Mutation_p.R60H|PPP2R1B_uc010rwi.1_Intron|PPP2R1B_uc010rwj.1_5'UTR|PPP2R1B_uc010rwk.1_Missense_Mutation_p.R60H|PPP2R1B_uc010rwl.1_Missense_Mutation_p.R60H	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	60	HEAT 2.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		ACAATTCACTTCGGGTCCTTTC	0.366													13	62					0	0	0.004672	0	0
C11orf1	64776	broad.mit.edu	37	11	111754511	111754511	+	Silent	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:111754511T>A	uc001pmd.2	+	4	697	c.360T>A	c.(358-360)CCT>CCA	p.P120P	C11orf1_uc001pme.2_Silent_p.P160P	NM_022761	NP_073598	Q9H5F2	CK001_HUMAN	hypothetical protein LOC64776	120						nucleus					0		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		AGCGAGAGCCTCACTGGTTCC	0.398													19	57					0	0	0.014323	0	0
TEX12	56158	broad.mit.edu	37	11	112041209	112041210	+	Missense_Mutation	DNP	CC	TT	TT	rs12294058	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:112041209_112041210CC>TT	uc001pnc.2	+	3	263_264	c.131_132CC>TT	c.(130-132)TCC>TTT	p.S44F	TEX12_uc001pnd.2_Missense_Mutation_p.S44F	NM_031275	NP_112565	Q9BXU0	TEX12_HUMAN	testis expressed sequence 12	44											0		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.2e-06)|BRCA - Breast invasive adenocarcinoma(274;1.4e-06)|all cancers(92;1.97e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0512)		TCTGAAATTTCCGGACTATTTT	0.342													11	37					0	0	0.004672	0	0
BUD13	84811	broad.mit.edu	37	11	116633693	116633693	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:116633693C>A	uc001ppn.2	-	4	646	c.612G>T	c.(610-612)AGG>AGT	p.R204S	BUD13_uc001ppo.2_Missense_Mutation_p.R204S|BUD13_uc009yzc.2_Missense_Mutation_p.R204S	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	204	Arg-rich.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GCTGAGGCCTCCTTGGGGGAG	0.552													53	229					1.83081e-24	1.98818e-24	0.014410	1	0
IL10RA	3587	broad.mit.edu	37	11	117859150	117859150	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:117859150C>T	uc001prv.2	+	2	198	c.121C>T	c.(121-123)CAC>TAC	p.H41Y	IL10RA_uc010rxl.1_Missense_Mutation_p.H21Y|IL10RA_uc010rxm.1_Missense_Mutation_p.H21Y|IL10RA_uc010rxn.1_5'UTR|IL10RA_uc001prw.2_5'UTR	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	41	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		ATTTTTCCACCACATCCTCCA	0.537													11	50					0	0	0.001855	0	0
SCN2B	6327	broad.mit.edu	37	11	118038887	118038887	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:118038887C>T	uc001psf.2	-	3	552	c.361G>A	c.(361-363)GAT>AAT	p.D121N		NM_004588	NP_004579	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta	121	Ig-like C2-type.|Extracellular (Potential).				synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity				0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		ATCCCCTCATCCTCCGGCTGC	0.567													7	14					0	0	0.003080	0	0
AMICA1	120425	broad.mit.edu	37	11	118083240	118083241	+	Missense_Mutation	DNP	GG	AA	AA	rs150593418		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:118083240_118083241GG>AA	uc001psk.2	-	3	253_254	c.79_80CC>TT	c.(79-81)CCG>TTG	p.P27L	AMICA1_uc001psh.2_5'UTR|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.P17L|AMICA1_uc001psj.2_Missense_Mutation_p.P27L|AMICA1_uc010rxw.1_5'UTR|AMICA1_uc010rxx.1_Missense_Mutation_p.P27L|AMICA1_uc001psl.1_Intron	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	27	Ig-like V-type 1.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TAGCTCAGGCGGGGAAACATTC	0.406													5	25					0	0	0.004672	0	0
TREH	11181	broad.mit.edu	37	11	118533871	118533871	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:118533871C>T	uc001pty.1	-	3	270	c.225G>A	c.(223-225)AGG>AGA	p.R75R	TREH_uc009zaj.1_Silent_p.R75R|TREH_uc001ptz.1_5'UTR|TREH_uc009zak.2_Silent_p.R75R	NM_007180	NP_009111	O43280	TREA_HUMAN	trehalase precursor	75					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			pancreas(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		GATTGTGGTCCCTGGACAGCT	0.617													4	15					0	0	0.009096	0	0
NLRX1	79671	broad.mit.edu	37	11	119053011	119053011	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:119053011C>T	uc001pvu.2	+	9	2778	c.2563C>T	c.(2563-2565)CTG>TTG	p.L855L	NLRX1_uc001pvv.2_Silent_p.L855L|NLRX1_uc001pvw.2_Silent_p.L855L|NLRX1_uc001pvx.2_Silent_p.L855L	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	855	LRR 6.|Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGCCCTGGCCCTGGCCAGAGC	0.657													13	41					0	0	0.002450	0	0
TECTA	7007	broad.mit.edu	37	11	120979943	120979943	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:120979943C>T	uc010rzo.1	+	3	222	c.222C>T	c.(220-222)TCC>TCT	p.S74S		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	74					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GAGTTGTTTCCTTCAATGTGC	0.458													6	15					0	0	0.001168	0	0
UBASH3B	84959	broad.mit.edu	37	11	122647802	122647802	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:122647802C>T	uc001pyi.3	+	3	646	c.286C>T	c.(286-288)CCC>TCC	p.P96S		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	96						cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		CTACCTCCGTCCCACCGGCCC	0.557													7	27					0	0	0.003080	0	0
SCN3B	55800	broad.mit.edu	37	11	123516315	123516315	+	Missense_Mutation	SNP	C	T	T	rs140381249		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:123516315C>T	uc001pza.1	-	3	606	c.199G>A	c.(199-201)GAG>AAG	p.E67K	SCN3B_uc001pzb.1_Missense_Mutation_p.E67K	NM_001040151	NP_001035241	Q9NY72	SCN3B_HUMAN	voltage-gated sodium channel beta-3 subunit	67	Ig-like C2-type.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		TTACCGCCCTCGGGCCTGTAG	0.597													18	70					0	0	0.007413	0	0
OR6M1	390261	broad.mit.edu	37	11	123676604	123676604	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:123676604G>A	uc010rzz.1	-	1	454	c.454C>T	c.(454-456)CTG>TTG	p.L152L		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		AACACAGACAGGAAGGCTCCC	0.507													11	21					0	0	0.010729	0	0
OR6M1	390261	broad.mit.edu	37	11	123676792	123676792	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:123676792G>A	uc010rzz.1	-	1	266	c.266C>T	c.(265-267)ACC>ATC	p.T89I		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		AAAAGATATGGTTTTCTCTTC	0.438													8	28					0	0	0.003080	0	0
VWA5A	4013	broad.mit.edu	37	11	124007759	124007759	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:124007759C>T	uc001pzu.2	+	15	1872	c.1663C>T	c.(1663-1665)CAG>TAG	p.Q555*	VWA5A_uc001pzt.2_Nonsense_Mutation_p.Q555*	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	555										upper_aerodigestive_tract(1)|ovary(1)	2						GTCCTTGCTCCAGACCAAGGA	0.453													8	44					0	0	0.006214	0	0
VWA5A	4013	broad.mit.edu	37	11	124012337	124012337	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:124012337C>T	uc001pzu.2	+	16	2121	c.1912C>T	c.(1912-1914)CCT>TCT	p.P638S	VWA5A_uc001pzt.2_Missense_Mutation_p.P638S	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	638										upper_aerodigestive_tract(1)|ovary(1)	2						TGACCGTCCTCCTTCTGCATC	0.478													11	52					0	0	0.013537	0	0
OR8D2	283160	broad.mit.edu	37	11	124189446	124189446	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:124189446G>A	uc010sah.1	-	1	648	c.648C>T	c.(646-648)ATC>ATT	p.I216I		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		AAGCATAAGAGATAAGGACCG	0.453													9	38					0	0	0.006214	0	0
OR8B2	26595	broad.mit.edu	37	11	124252337	124252337	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:124252337C>T	uc010sai.1	-	1	903	c.903G>A	c.(901-903)AGG>AGA	p.R301R		NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TCAGAGCTTTCCTCAGTGCAA	0.348													9	43					0	0	0.006214	0	0
OR8B4	283162	broad.mit.edu	37	11	124294000	124294000	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:124294000G>A	uc010sak.1	-	1	768	c.768C>T	c.(766-768)TTC>TTT	p.F256F		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TTAAGTAGGTGAATGTCCCTG	0.458													5	11					0	0	0.001168	0	0
ROBO4	54538	broad.mit.edu	37	11	124767092	124767092	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:124767092G>A	uc001qbg.2	-	2	276	c.136C>T	c.(136-138)CCT>TCT	p.P46S	ROBO4_uc010sas.1_Intron|ROBO4_uc001qbh.2_Intron|ROBO4_uc010sat.1_5'Flank	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	46	Ig-like C2-type 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GCAGGGCCAGGGCCCTGGAAC	0.667													3	13					0	0	0.004672	0	0
CDON	50937	broad.mit.edu	37	11	125888225	125888225	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:125888225G>A	uc009zbw.2	-	5	768	c.640C>T	c.(640-642)CGT>TGT	p.R214C	CDON_uc001qdc.3_Missense_Mutation_p.R214C|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.R214C	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	214	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		AAATACTTACGACTCACAAGG	0.368													12	34					0	0	0.013537	0	0
ST14	6768	broad.mit.edu	37	11	130068470	130068470	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:130068470G>A	uc001qfw.2	+	14	1831	c.1638G>A	c.(1636-1638)GGG>GGA	p.G546G		NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	546	Extracellular (Potential).|LDL-receptor class A 3.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	AGTGCAATGGGAAGGACGACT	0.657													4	22					0	0	0.000602	0	0
GLB1L2	89944	broad.mit.edu	37	11	134244587	134244587	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:134244587C>T	uc001qhp.2	+	18	1987	c.1799C>T	c.(1798-1800)CCC>CTC	p.P600L	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	600					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CTCCCAGGTCCCTGGTTGAGC	0.592													17	64					0	0	0.007413	0	0
KDM5A	5927	broad.mit.edu	37	12	432786	432786	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:432786G>A	uc001qif.1	-	15	2493	c.2130C>T	c.(2128-2130)CCC>CCT	p.P710P	KDM5A_uc001qie.1_Silent_p.P710P|KDM5A_uc010sdn.1_Silent_p.P669P|KDM5A_uc010sdo.1_Silent_p.P329P	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	710					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						TCTTCTGCATGGGGCAGGGGC	0.388			T 	NUP98	AML								15	73					0	0	0.008871	0	0
KDM5A	5927	broad.mit.edu	37	12	493221	493221	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:493221G>A	uc001qif.1	-	3	705	c.342C>T	c.(340-342)ATC>ATT	p.I114I	KDM5A_uc001qie.1_Silent_p.I114I|KDM5A_uc010sdn.1_Intron|KDM5A_uc010sdo.1_Intron	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	114	ARID.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						ACAGATCCAGGATTTTTCTCT	0.398			T 	NUP98	AML								16	133					0	0	0.004990	0	0
WNK1	65125	broad.mit.edu	37	12	989990	989990	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:989990C>T	uc001qio.3	+	12	3443	c.2936C>T	c.(2935-2937)CCC>CTC	p.P979L	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	979					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CTATCCCCTCCCATGCCGACA	0.502													16	224					0	0	0.007413	0	0
FBXL14	144699	broad.mit.edu	37	12	1675932	1675932	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:1675932C>T	uc001qjh.2	-	2	1338	c.1239G>A	c.(1237-1239)CGG>CGA	p.R413R		NM_152441	NP_689654	Q8N1E6	FXL14_HUMAN	F-box and leucine-rich repeat protein 14	413						cytoplasm				ovary(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00115)			tggagcttccccgagttctca	0													5	67					0	0	0.001168	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1969363	1969363	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:1969363G>A	uc001qjp.2	-	19	2119	c.1888C>T	c.(1888-1890)CTT>TTT	p.L630F	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.L494F	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	630	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GTCAGGAAAAGAACTCGCTTC	0.547													3	16					0	0	0.000602	0	0
CACNA1C	775	broad.mit.edu	37	12	2706436	2706436	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:2706436C>T	uc009zdu.1	+	21	3147	c.2834C>T	c.(2833-2835)ACC>ATC	p.T945I	CACNA1C_uc009zdv.1_Missense_Mutation_p.T942I|CACNA1C_uc001qkb.2_Intron|CACNA1C_uc001qkc.2_Intron|CACNA1C_uc001qke.2_Intron|CACNA1C_uc001qkf.2_Intron|CACNA1C_uc001qjz.2_Missense_Mutation_p.T945I|CACNA1C_uc001qkd.2_Missense_Mutation_p.T945I|CACNA1C_uc001qkg.2_Missense_Mutation_p.T945I|CACNA1C_uc009zdw.1_Missense_Mutation_p.T945I|CACNA1C_uc001qkh.2_Missense_Mutation_p.T945I|CACNA1C_uc001qkl.2_Missense_Mutation_p.T945I|CACNA1C_uc001qkn.2_Intron|CACNA1C_uc001qko.2_Missense_Mutation_p.T945I|CACNA1C_uc001qkp.2_Intron|CACNA1C_uc001qkr.2_Intron|CACNA1C_uc001qku.2_Intron|CACNA1C_uc001qkq.2_Missense_Mutation_p.T945I|CACNA1C_uc001qks.2_Missense_Mutation_p.T945I|CACNA1C_uc001qkt.2_Missense_Mutation_p.T945I|CACNA1C_uc001qka.1_Intron|CACNA1C_uc001qki.1_Missense_Mutation_p.T681I|CACNA1C_uc001qkj.1_Missense_Mutation_p.T681I|CACNA1C_uc001qkk.1_Missense_Mutation_p.T681I|CACNA1C_uc001qkm.1_Missense_Mutation_p.T681I	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	945	III.|Helical; Name=S2 of repeat III; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACCATTTTCACCATTGAAATT	0.498													9	128					0	0	0.006214	0	0
CACNA1C	775	broad.mit.edu	37	12	2714934	2714934	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:2714934C>T	uc009zdu.1	+	25	3511	c.3198C>T	c.(3196-3198)ATC>ATT	p.I1066I	CACNA1C_uc009zdv.1_Silent_p.I1043I|CACNA1C_uc001qkb.2_Silent_p.I1046I|CACNA1C_uc001qkc.2_Silent_p.I1046I|CACNA1C_uc001qke.2_Silent_p.I1046I|CACNA1C_uc001qkf.2_Silent_p.I1046I|CACNA1C_uc001qjz.2_Silent_p.I1046I|CACNA1C_uc001qkd.2_Silent_p.I1046I|CACNA1C_uc001qkg.2_Silent_p.I1046I|CACNA1C_uc009zdw.1_Silent_p.I1046I|CACNA1C_uc001qkh.2_Silent_p.I1046I|CACNA1C_uc001qkl.2_Silent_p.I1066I|CACNA1C_uc001qkn.2_Silent_p.I1046I|CACNA1C_uc001qko.2_Silent_p.I1066I|CACNA1C_uc001qkp.2_Silent_p.I1046I|CACNA1C_uc001qkr.2_Silent_p.I1046I|CACNA1C_uc001qku.2_Silent_p.I1046I|CACNA1C_uc001qkq.2_Silent_p.I1046I|CACNA1C_uc001qks.2_Silent_p.I1046I|CACNA1C_uc001qkt.2_Silent_p.I1046I|CACNA1C_uc001qka.1_Silent_p.I581I|CACNA1C_uc001qki.1_Silent_p.I782I|CACNA1C_uc001qkj.1_Silent_p.I782I|CACNA1C_uc001qkk.1_Silent_p.I782I|CACNA1C_uc001qkm.1_Silent_p.I782I	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1066	III.|Helical; Name=S5 of repeat III; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TTGCCTGCATCGGGGTCCAGC	0.552													5	39					0	0	0.001168	0	0
TEAD4	7004	broad.mit.edu	37	12	3120219	3120219	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:3120219C>T	uc010sej.1	+	4	550	c.273C>T	c.(271-273)ACC>ACT	p.T91T	TEAD4_uc010sek.1_Silent_p.T91T|TEAD4_uc001qln.2_5'UTR	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	92	TEA.				hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CAGGGAAGACCCGCACCAGGA	0.637													7	64					0	0	0.001984	0	0
GALNT8	26290	broad.mit.edu	37	12	4829879	4829879	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:4829879C>T	uc001qne.1	+	1	128	c.36C>T	c.(34-36)TTC>TTT	p.F12F		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	12	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						AAGCCCTCTTCATTGGGCTGA	0.512													8	51					0	0	0.008291	0	0
KCNA1	3736	broad.mit.edu	37	12	5021486	5021486	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:5021486C>T	uc001qnh.2	+	2	2047	c.942C>T	c.(940-942)ATC>ATT	p.I314I		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	314					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GCCTCCAGATCCTGGGCCAGA	0.547													5	45					0	0	0.000602	0	0
ANO2	57101	broad.mit.edu	37	12	5756932	5756932	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:5756932G>A	uc001qnm.2	-	16	1653	c.1581C>T	c.(1579-1581)TTC>TTT	p.F527F		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	532	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						GGTAACCTGGGAAACGATCCT	0.438													3	16					0	0	0.009096	0	0
ANO2	57101	broad.mit.edu	37	12	5915235	5915235	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:5915235C>T	uc001qnm.2	-	9	1033	c.961G>A	c.(961-963)GAT>AAT	p.D321N		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	326	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						TCATTCATATCGTCCTCTGGA	0.478													6	40					0	0	0.001984	0	0
VWF	7450	broad.mit.edu	37	12	6122716	6122716	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:6122716G>A	uc001qnn.1	-	32	5801	c.5551C>T	c.(5551-5553)CTC>TTC	p.L1851F	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1851	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	ATTCGCTGGAGCTTCACCACG	0.522													4	70					0	0	0.009096	0	0
NOP2	4839	broad.mit.edu	37	12	6675733	6675733	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:6675733G>A	uc001qpk.1	-	3	244	c.200C>T	c.(199-201)TCT>TTT	p.S67F	NOP2_uc001qph.1_Missense_Mutation_p.S67F|NOP2_uc001qpi.1_Missense_Mutation_p.S67F|NOP2_uc001qpj.1_Intron|NOP2_uc001qpl.1_Missense_Mutation_p.S67F|NOP2_uc001qpm.1_Missense_Mutation_p.S67F			P46087	NOP2_HUMAN	Homo sapiens cDNA FLJ31646 fis, clone NT2RI2003921, highly similar to PROLIFERATING-CELL NUCLEOLAR ANTIGEN P120.	67					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						GGCCTCAGGAGACTTATTTGT	0.488													9	65					0	0	0.008291	0	0
GNB3	2784	broad.mit.edu	37	12	6953089	6953089	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:6953089G>A	uc001qrd.2	+	9	1051	c.646G>A	c.(646-648)GGG>AGG	p.G216R	GNB3_uc001qrc.2_Missense_Mutation_p.G172R|GNB3_uc009zfe.2_Missense_Mutation_p.G215R	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	216					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						TGTGCGAGAGGGGACCTGCCG	0.592													5	47					0	0	0.000602	0	0
PTPN6	5777	broad.mit.edu	37	12	7067172	7067172	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:7067172C>T	uc001qsb.2	+	11	1539	c.1297C>T	c.(1297-1299)CTG>TTG	p.L433L	PTPN6_uc001qsa.1_Silent_p.L435L|PTPN6_uc010sfr.1_Silent_p.L394L|PTPN6_uc009zfl.1_Silent_p.L433L|PTPN6_uc010sfs.1_Silent_p.L421L	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	433	Tyrosine-protein phosphatase.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						CCTCAGCTTCCTGGACCAGAT	0.587													4	40					0	0	0.000602	0	0
C1RL	51279	broad.mit.edu	37	12	7249576	7249576	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:7249576G>A	uc001qsn.2	-	6	892	c.875C>T	c.(874-876)TCT>TTT	p.S292F	C1RL_uc009zft.2_Missense_Mutation_p.L308F	NM_016546	NP_057630	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	292	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			pancreas(1)	1						CTTCCTGAGAGAAACACTGTC	0.582													9	34					0	0	0.004482	0	0
CD163L1	283316	broad.mit.edu	37	12	7527908	7527908	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:7527908G>A	uc001qsy.2	-	11	2996	c.2970C>T	c.(2968-2970)ATC>ATT	p.I990I	CD163L1_uc010sge.1_Silent_p.I1000I	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	990	SRCR 9.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TATTTCCATGGATACAGGGAG	0.438													7	28					0	0	0.004482	0	0
CD163L1	283316	broad.mit.edu	37	12	7531617	7531617	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:7531617C>T	uc001qsy.2	-	9	2354	c.2328G>A	c.(2326-2328)CAG>CAA	p.Q776Q	CD163L1_uc010sge.1_Silent_p.Q786Q	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	776	SRCR 7.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GACACGCAGTCTGTTTCCACT	0.358													5	77					0	0	0.001168	0	0
CD163	9332	broad.mit.edu	37	12	7640503	7640503	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:7640503C>T	uc001qsz.3	-	7	1729	c.1601G>A	c.(1600-1602)GGA>GAA	p.G534E	CD163_uc001qta.3_Missense_Mutation_p.G534E|CD163_uc009zfw.2_Missense_Mutation_p.G534E	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	534	SRCR 5.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						ATTTCCCTCTCCAAAGTGAGC	0.527													6	40					0	0	0.001984	0	0
DPPA3	359787	broad.mit.edu	37	12	7867976	7867976	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:7867976G>A	uc001qtf.2	+	2	358	c.280G>A	c.(280-282)GAA>AAA	p.E94K		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	94						cytoplasm|nucleus					0				Kidney(36;0.0887)		TGTGCAGAGAGAAAAGATGGC	0.502													6	29					0	0	0.001984	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374826	8374826	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:8374826C>T	uc001qui.2	-	7	1546	c.987G>A	c.(985-987)GAG>GAA	p.E329E	FAM90A1_uc001quh.2_Silent_p.E329E	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	329							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		GTTGGAGATTCTCCGGGGCCC	0.647													4	11					0	0	0.009096	0	0
CLEC4E	26253	broad.mit.edu	37	12	8687247	8687247	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:8687247C>T	uc001quo.1	-	6	812	c.647G>A	c.(646-648)GGA>GAA	p.G216E		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	216	Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					AAGAGATTTTCCTTTGTTCAA	0.408													7	34					0	0	0.003080	0	0
A2M	2	broad.mit.edu	37	12	9243046	9243046	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:9243046G>A	uc001qvk.1	-	20	2615	c.2502C>T	c.(2500-2502)TTC>TTT	p.F834F	A2M_uc009zgk.1_Silent_p.F684F	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	834					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GGACAGCTAGGAAGGCGGGAG	0.532													7	84					0	0	0.001984	0	0
A2M	2	broad.mit.edu	37	12	9264775	9264775	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:9264775A>T	uc001qvk.1	-	4	576	c.463T>A	c.(463-465)TTT>ATT	p.F155I	A2M_uc009zgk.1_Missense_Mutation_p.F5I	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	155					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	AGGGGGTGAAAGTTTTCATCC	0.408													12	39					0	0	0.001855	0	0
C12orf59	120939	broad.mit.edu	37	12	10339110	10339110	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:10339110G>A	uc001qxr.2	+	4	846	c.229G>A	c.(229-231)GAA>AAA	p.E77K	C12orf59_uc001qxq.2_Missense_Mutation_p.E57K			Q4KMG9	CL059_HUMAN	RecName: Full=Uncharacterized protein C12orf59; Flags: Precursor;	77						integral to membrane				ovary(1)	1						GCAAAATGGGGAAGATGGGGG	0.547													8	72					0	0	0.004482	0	0
PRH1	5554	broad.mit.edu	37	12	11034873	11034873	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:11034873G>A	uc001qzc.2	-	8	1050	c.462C>T	c.(460-462)GGC>GGT	p.G154G	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_RNA|PRB4_uc001qzf.1_Intron	NM_006250	NP_006241	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 1	154						extracellular space	protein binding				0				BRCA - Breast invasive adenocarcinoma(232;0.245)		CTTGTGGGCGGCCCCCTTGGG	0.582													11	112					0	0	0.003163	0	0
PRB3	5544	broad.mit.edu	37	12	11420548	11420548	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:11420548C>T	uc001qzs.2	-	3	673	c.635G>A	c.(634-636)GGA>GAA	p.G212E	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	212	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|8.|Pro-rich.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGACTGGTTTCCTCCTTGTGG	0.622													27	244					0	0	0.014410	0	0
PRB3	5544	broad.mit.edu	37	12	11420611	11420611	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:11420611C>T	uc001qzs.2	-	3	610	c.572G>A	c.(571-573)GGA>GAA	p.G191E	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	191	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|7.|Pro-rich.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGACTGGTTTCCTCCTTGTGG	0.637													7	232					0	0	0.001855	0	0
PRB3	5544	broad.mit.edu	37	12	11420937	11420937	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:11420937G>A	uc001qzs.2	-	3	284	c.246C>T	c.(244-246)CCC>CCT	p.P82P	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	82	2.|10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			CTCCTTGTGGGGGTGGTCCTT	0.627													41	206					0	0	0.014410	0	0
PRB1	5542	broad.mit.edu	37	12	11506846	11506846	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:11506846C>T	uc001qzw.1	-	3	228	c.191G>A	c.(190-192)GGA>GAA	p.G64E	PRB1_uc001qzu.1_Missense_Mutation_p.G64E|PRB1_uc001qzv.1_Missense_Mutation_p.G64E	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	125	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].|4.		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele M).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTGTTGCCTCCTTGTGGGGG	0.607													13	201					0	0	0.001855	0	0
GRIN2B	2904	broad.mit.edu	37	12	13828691	13828691	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:13828691C>T	uc001rbt.2	-	4	1292	c.1113G>A	c.(1111-1113)AGG>AGA	p.R371R		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	371	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTTCCCACTTCCTCTCCTTGT	0.408													16	62					0	0	0.004990	0	0
GRIN2B	2904	broad.mit.edu	37	12	14018773	14018773	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:14018773G>A	uc001rbt.2	-	2	549	c.370C>T	c.(370-372)CTG>TTG	p.L124L		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	124	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGATGCCCAGGATGGGGGTG	0.547													16	133					0	0	0.004007	0	0
WBP11	51729	broad.mit.edu	37	12	14947951	14947951	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:14947951G>A	uc001rci.2	-	6	636	c.475C>T	c.(475-477)CCT>TCT	p.P159S		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	159	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						TGGGCACCAGGAAGTGGAATG	0.463													12	100					0	0	0.004007	0	0
RERG	85004	broad.mit.edu	37	12	15262375	15262375	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:15262375C>T	uc001rcs.2	-	4	409	c.269G>A	c.(268-270)GGA>GAA	p.G90E	RERG_uc001rct.2_Missense_Mutation_p.G90E|RERG_uc010shu.1_Missense_Mutation_p.G71E	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	90					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						CTCAAAACTTCCTCGGTCAGT	0.478													73	256					0	0	0.014410	0	0
PTPRO	5800	broad.mit.edu	37	12	15742453	15742453	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:15742453C>T	uc001rcv.1	+	25	3649	c.3475C>T	c.(3475-3477)CAT>TAT	p.H1159Y	PTPRO_uc001rcw.1_Missense_Mutation_p.H1131Y|PTPRO_uc001rcx.1_Missense_Mutation_p.H348Y|PTPRO_uc001rcy.1_Missense_Mutation_p.H348Y|PTPRO_uc001rcz.1_Missense_Mutation_p.H320Y|PTPRO_uc001rda.1_Missense_Mutation_p.H320Y	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	1159	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				CATTCGGGATCATGAGTTTGT	0.443													15	77					0	0	0.003163	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18443928	18443928	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:18443928C>T	uc001rdt.2	+	4	1017	c.901C>T	c.(901-903)CTT>TTT	p.L301F	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.L301F|PIK3C2G_uc010sic.1_Missense_Mutation_p.L79F	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	301					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				AACACAACCTCTTCATTTTAT	0.363													6	21					0	0	0.001168	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19512471	19512471	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:19512471C>T	uc001reb.2	+	22	3062	c.2976C>T	c.(2974-2976)TTC>TTT	p.F992F	PLEKHA5_uc010sie.1_Silent_p.F1153F|PLEKHA5_uc001rea.2_Silent_p.F1050F|PLEKHA5_uc009zin.2_Silent_p.F750F|PLEKHA5_uc010sif.1_Silent_p.F981F|PLEKHA5_uc010sig.1_Silent_p.F974F|PLEKHA5_uc010sih.1_Silent_p.F947F|PLEKHA5_uc001rec.1_Silent_p.F801F|PLEKHA5_uc009zio.2_Silent_p.F258F	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	992							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					ATGTGGACTTCAGCAAAGAGG	0.358													7	11					0	0	0.003080	0	0
PDE3A	5139	broad.mit.edu	37	12	20803529	20803529	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:20803529G>A	uc001reh.1	+	14	2942	c.2920G>A	c.(2920-2922)GAA>AAA	p.E974K		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	974	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TGAATTTTATGAACAGGTAAC	0.363													5	39					0	0	0.001168	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21242929	21242929	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:21242929C>T	uc010sil.1	+	16	2201	c.2136C>T	c.(2134-2136)TCC>TCT	p.S712S	LST-3TM12_uc010sim.1_Silent_p.S651S|LST-3TM12_uc010sin.1_Silent_p.S604S			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					GGAAAAAATCCCATGGAAAGG	0.343													4	19					0	0	0.009096	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21370151	21370151	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:21370151G>A	uc001req.3	+	12	1700	c.1596G>A	c.(1594-1596)AGG>AGA	p.R532R		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	532	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CTTGTACAAGGAAATTTTACT	0.378													9	52					0	0	0.006214	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21457425	21457425	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:21457425G>A	uc001rer.2	-	5	776	c.525C>T	c.(523-525)ATC>ATT	p.I175I	SLCO1A2_uc001res.2_Silent_p.I175I|SLCO1A2_uc010siq.1_Silent_p.I43I|SLCO1A2_uc010sio.1_Silent_p.I43I|SLCO1A2_uc010sip.1_Silent_p.I43I|SLCO1A2_uc001ret.2_Silent_p.I173I|SLCO1A2_uc001reu.2_Silent_p.I155I	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	175	Helical; Name=4; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						CCAAAGGCAGGATGGGAGTTT	0.353													9	33					0	0	0.008291	0	0
C12orf39	80763	broad.mit.edu	37	12	21679878	21679878	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:21679878G>A	uc001rfa.1	+	2	216	c.65G>A	c.(64-66)GGA>GAA	p.G22E	C12orf39_uc009ziv.1_5'Flank|C12orf39_uc009ziw.1_5'Flank	NM_030572	NP_085049	Q9BT56	SPXN_HUMAN	spexin precursor	22						extracellular region|nucleus|transport vesicle					0						GTTTTCCTGGGAAACTCCAGC	0.438													13	100					0	0	0.002450	0	0
GYS2	2998	broad.mit.edu	37	12	21727182	21727182	+	Nonsense_Mutation	SNP	G	A	A	rs150382575		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:21727182G>A	uc001rfb.2	-	4	829	c.574C>T	c.(574-576)CGA>TGA	p.R192*		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	192					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						TTCCTGGCTCGAGAAAGGATC	0.418													5	35					0	0	0.000602	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919242	21919242	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:21919242G>A	uc001rff.2	-	3	1028	c.690C>T	c.(688-690)GTC>GTT	p.V230V		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	230	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	TTGTTTTCTTGACCACCTGGA	0.493													14	72					0	0	0.003163	0	0
ABCC9	10060	broad.mit.edu	37	12	21970121	21970122	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:21970121_21970122CC>TT	uc001rfi.1	-	31	3911_3912	c.3891_3892GG>AA	c.(3889-3894)ATGGAT>ATAAAT	p.1297_1298MD>IN	ABCC9_uc001rfh.2_Missense_Mutation_p.1297_1298MD>IN|ABCC9_uc001rfj.1_Missense_Mutation_p.1261_1262MD>IN	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1297_1298	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGAGCAATACCCATTGTGCCTT	0.401													12	131					0	0	0.004672	0	0
ABCC9	10060	broad.mit.edu	37	12	22005418	22005418	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:22005418C>T	uc001rfi.1	-	21	2547	c.2527G>A	c.(2527-2529)GAC>AAC	p.D843N	ABCC9_uc001rfh.2_Missense_Mutation_p.D843N|ABCC9_uc001rfj.1_Missense_Mutation_p.D807N	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	843	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AAGTGAATGTCCAGGGCTGAG	0.378													4	32					0	0	0.000602	0	0
ABCC9	10060	broad.mit.edu	37	12	22048214	22048214	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:22048214G>A	uc001rfi.1	-	11	1674	c.1654C>T	c.(1654-1656)CTT>TTT	p.L552F	ABCC9_uc001rfh.2_Missense_Mutation_p.L552F|ABCC9_uc001rfj.1_Missense_Mutation_p.L552F	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	552	Helical; Name=10; (Potential).|ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTTACAGCAAGAACAGCTGCT	0.318													4	39					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	12	24736623	24736623	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:24736623C>T	uc001rgb.1	-	1		c.480G>A								Homo sapiens cDNA FLJ32894 fis, clone TESTI2004994.																		TCTGCGAGGTCGGGGATGCTG	0.557													10	65					0	0	0.006214	0	0
IFLTD1	160492	broad.mit.edu	37	12	25699357	25699357	+	Silent	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:25699357A>G	uc001rgs.2	-	3	529	c.379T>C	c.(379-381)TTA>CTA	p.L127L	IFLTD1_uc001rgt.1_Silent_p.L30L|IFLTD1_uc010sji.1_Silent_p.L148L|IFLTD1_uc010sjj.1_Silent_p.L64L|IFLTD1_uc009zjc.2_Silent_p.L148L	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	127						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					AAGTATTTTAAAGTTTTCTGA	0.358													3	57					0	0	0.009096	0	0
ARNTL2	56938	broad.mit.edu	37	12	27553489	27553489	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:27553489C>T	uc001rht.1	+	10	960	c.942C>T	c.(940-942)ATC>ATT	p.I314I	ARNTL2_uc001rhw.2_Silent_p.I277I|ARNTL2_uc010sjp.1_Silent_p.I277I|ARNTL2_uc001rhu.1_Silent_p.I300I|ARNTL2_uc009zji.1_Silent_p.I280I|ARNTL2_uc001rhv.1_Silent_p.I266I|uc001rhx.2_Intron	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	314					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					TCTATACTATCCATTGCACTG	0.313													4	38					0	0	0.000602	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27841341	27841341	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:27841341C>T	uc001ric.1	+	25	2876	c.2499C>T	c.(2497-2499)GTC>GTT	p.V833V	PPFIBP1_uc010sjr.1_Silent_p.V664V|PPFIBP1_uc001rib.1_Silent_p.V827V|PPFIBP1_uc001ria.2_Silent_p.V802V|PPFIBP1_uc001rid.1_Silent_p.V680V|PPFIBP1_uc001rif.1_Silent_p.V340V	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	833	SAM 3.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					GCAGTGGTGTCCATGGTGGGC	0.438													37	182					0	0	0.009718	0	0
OVCH1	341350	broad.mit.edu	37	12	29630406	29630406	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:29630406C>T	uc001rix.1	-	11	1114	c.1114G>A	c.(1114-1116)GTC>ATC	p.V372I		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	372	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TTTCCACAGACCTTACCTTAA	0.403													8	50					0	0	0.003080	0	0
Unknown	0	broad.mit.edu	37	12	31311984	31311984	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:31311984G>A	uc010sjy.1	-	5	446	c.446C>T	c.(445-447)CCT>CTT	p.P149L						RecName: Full=Ovostatin homolog 1; Flags: Precursor;																		ATTGTTTTGAGGATCCTAGAA	0.338													10	34					0	0	0.006214	0	0
SYT10	341359	broad.mit.edu	37	12	33579224	33579224	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:33579224C>T	uc001rll.1	-	2	655	c.358G>A	c.(358-360)GAA>AAA	p.E120K	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	120	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GCTGGCTTTTCATTTTCCTTA	0.398													19	87					0	0	0.010504	0	0
SYT10	341359	broad.mit.edu	37	12	33592367	33592367	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:33592367A>T	uc001rll.1	-	1	388	c.91T>A	c.(91-93)TGG>AGG	p.W31R	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	31	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CACTTCTCCCACTCCACCTGG	0.642													6	115					0	0	0.001168	0	0
KIF21A	55605	broad.mit.edu	37	12	39763563	39763563	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:39763563G>A	uc001rly.2	-	3	564	c.418C>T	c.(418-420)CCA>TCA	p.P140S	KIF21A_uc001rlx.2_Missense_Mutation_p.P140S|KIF21A_uc001rlz.2_Missense_Mutation_p.P140S|KIF21A_uc010skl.1_Missense_Mutation_p.P140S|KIF21A_uc001rma.1_Missense_Mutation_p.P140S	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	140	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TTAAAATCTGGAGCAGGAAGC	0.299													4	48					0	0	0.001168	0	0
C12orf40	283461	broad.mit.edu	37	12	40044066	40044066	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:40044066C>T	uc001rmc.2	+	7	763	c.596C>T	c.(595-597)TCC>TTC	p.S199F	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	199										ovary(6)	6						TGTTCTGATTCCTTGCTTTCC	0.279													7	36					0	0	0.001984	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45457352	45457352	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:45457352G>A	uc001rol.2	-	1		c.1843C>T				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						TCTTTGTGAGGGTGGAACAGA	0.473													11	24					0	0	0.008291	0	0
SLC38A1	81539	broad.mit.edu	37	12	46601349	46601349	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:46601349G>A	uc001rpa.2	-	7	702	c.444C>T	c.(442-444)TTC>TTT	p.F148F	SLC38A1_uc001rpb.2_Silent_p.F148F|SLC38A1_uc001rpc.2_Silent_p.F148F|SLC38A1_uc001rpd.2_Silent_p.F148F|SLC38A1_uc001rpe.2_Silent_p.F148F|SLC38A1_uc010slh.1_Silent_p.F121F|SLC38A1_uc009zkj.1_Silent_p.F148F	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	148	Helical; (Potential).				cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			CAAAGATTACGAACTTCCCTG	0.413													13	75					0	0	0.004990	0	0
SLC38A4	55089	broad.mit.edu	37	12	47181749	47181749	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:47181749C>T	uc001rpi.2	-	5	675	c.276G>A	c.(274-276)GGG>GGA	p.G92G	SLC38A4_uc001rpj.2_Silent_p.G92G|SLC38A4_uc009zkl.2_Silent_p.G92G	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	92	Helical; (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					AGCCCAGGATCCCACTGCCCA	0.418													10	44					0	0	0.001855	0	0
SLC38A4	55089	broad.mit.edu	37	12	47186763	47186763	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:47186763C>T	uc001rpi.2	-	3	491	c.92G>A	c.(91-93)GGA>GAA	p.G31E	SLC38A4_uc001rpj.2_Missense_Mutation_p.G31E|SLC38A4_uc009zkl.2_Missense_Mutation_p.G31E	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	31	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					TTCTGAATTTCCTATCCCGAT	0.428													23	89					0	0	0.004656	0	0
FAM113B	91523	broad.mit.edu	37	12	47629084	47629084	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:47629084C>T	uc001rpn.2	+	4	969	c.238C>T	c.(238-240)CGC>TGC	p.R80C	FAM113B_uc010slj.1_Intron|FAM113B_uc001rpq.2_Missense_Mutation_p.R80C	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	80							hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					CCGTGAGGTCCGCGAGTTCCG	0.582													5	58					0	0	0.000602	0	0
TMEM106C	79022	broad.mit.edu	37	12	48359877	48359877	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:48359877C>T	uc001rqp.2	+	5	532	c.417C>T	c.(415-417)ACC>ACT	p.T139T	TMEM106C_uc001rqo.2_Silent_p.T139T|TMEM106C_uc001rqr.2_Silent_p.T139T|TMEM106C_uc001rqq.2_Silent_p.T139T	NM_024056	NP_076961	Q9BVX2	T106C_HUMAN	transmembrane protein 106C isoform a	139						endoplasmic reticulum membrane|integral to membrane					0		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		TGTAGGCCACCCTGAAAATCA	0.512													8	39					0	0	0.004482	0	0
COL2A1	1280	broad.mit.edu	37	12	48391405	48391405	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:48391405G>A	uc001rqu.2	-	7	696	c.515C>T	c.(514-516)CCC>CTC	p.P172L	COL2A1_uc001rqv.2_Missense_Mutation_p.P103L	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	172					axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	AAgaccagggggaccaggggg	0.408													5	26					0	0	0.000602	0	0
LALBA	3906	broad.mit.edu	37	12	48962326	48962326	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:48962326G>A	uc001rrt.2	-	3	368	c.342C>T	c.(340-342)ATC>ATT	p.I114I		NM_002289	NP_002280	P00709	LALBA_HUMAN	lactalbumin, alpha- precursor	114					cell-cell signaling|defense response to bacterium|induction of apoptosis|lactose biosynthetic process|signal transduction	extracellular space	calcium ion binding|lactose synthase activity				0						TAATATCCAGGATCTTCTTGG	0.438													4	48					0	0	0.000602	0	0
MLL2	8085	broad.mit.edu	37	12	49444864	49444864	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:49444864G>C	uc001rta.3	-	10	2602	c.2602C>G	c.(2602-2604)CCT>GCT	p.P868A		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	868	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCTCCTCAGGGGGCTTTTCA	0.647			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			11	72					0	0	0.008291	0	0
MLL2	8085	broad.mit.edu	37	12	49445952	49445952	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:49445952G>A	uc001rta.3	-	10	1514	c.1514C>T	c.(1513-1515)CCC>CTC	p.P505L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	505	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.|5.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTCAGGTGGGGGAGACAGAGG	0.612			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			16	45					0	0	0.003163	0	0
GALNT6	11226	broad.mit.edu	37	12	51748276	51748276	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:51748276C>T	uc001ryk.2	-	11	1981	c.1756G>A	c.(1756-1758)GAT>AAT	p.D586N	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Missense_Mutation_p.D586N|GALNT6_uc001ryj.1_Missense_Mutation_p.D151N	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	586	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						ATGAGCTGATCCTAAAAGATG	0.527													4	33					0	0	0.000602	0	0
KRT6B	3854	broad.mit.edu	37	12	52841600	52841600	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:52841600G>A	uc001sak.2	-	7	1434	c.1386C>T	c.(1384-1386)ATC>ATT	p.I462I		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	462	Rod.|Coil 2.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		GGTAGGTGGCGATCTCCACAT	0.612													22	65					0	0	0.002780	0	0
KRT71	112802	broad.mit.edu	37	12	52940248	52940248	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:52940248C>T	uc001sao.2	-	7	1217	c.1147G>A	c.(1147-1149)GGA>AGA	p.G383R		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	383	Coil 2.|Rod.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		GCGTTGTCTCCCCGCTGCTCA	0.607													9	15					0	0	0.006214	0	0
KRT71	112802	broad.mit.edu	37	12	52943997	52943997	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:52943997G>A	uc001sao.2	-	2	542	c.472C>T	c.(472-474)CTG>TTG	p.L158L		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	158	Coil 1A.|Rod.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		TTGGTCTCCAGTACCTGGTTC	0.542													11	52					0	0	0.010729	0	0
KRT2	3849	broad.mit.edu	37	12	53045717	53045717	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:53045717C>T	uc001sat.2	-	1	243	c.210G>A	c.(208-210)AAG>AAA	p.K70K		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	70	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		TGGAGATGCTCTTGGTCCCTC	0.353													5	32					0	0	0.001168	0	0
KRT76	51350	broad.mit.edu	37	12	53170973	53170973	+	Missense_Mutation	SNP	G	A	A	rs145777357	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:53170973G>A	uc001sax.2	-	1	157	c.103C>T	c.(103-105)CGC>TGC	p.R35C		NM_015848	NP_056932	Q01546	K22O_HUMAN	keratin 76	35	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|skin(1)	2						CCCCCAGAGCGGGCCACACAG	0.612													5	46					0	0	0.001168	0	0
COPZ1	22818	broad.mit.edu	37	12	54743418	54743418	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:54743418C>T	uc001sfs.1	+	8	499	c.462C>T	c.(460-462)CCC>CCT	p.P154P	COPZ1_uc001sft.2_Silent_p.P103P|COPZ1_uc009znm.1_Silent_p.P162P|COPZ1_uc010sot.1_Silent_p.P131P	NM_016057	NP_057141	P61923	COPZ1_HUMAN	coatomer protein complex, subunit zeta 1	154					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol					0						AAGATGTCCCCCTTACGGAGC	0.478													32	228					0	0	0.005524	0	0
ZNF385A	25946	broad.mit.edu	37	12	54764811	54764812	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:54764811_54764812CC>TT	uc001sfw.1	-	5	856_857	c.673_674GG>AA	c.(673-675)GGG>AAG	p.G225K	ZNF385A_uc001sfv.1_Missense_Mutation_p.G206K|ZNF385A_uc009zno.1_RNA|ZNF385A_uc010sov.1_Missense_Mutation_p.G144K|ZNF385A_uc001sfx.1_Missense_Mutation_p.G225K|ZNF385A_uc001sfy.3_Missense_Mutation_p.G245K|ZNF385A_uc001sfz.3_Missense_Mutation_p.G164K	NM_015481	NP_056296	Q96PM9	Z385A_HUMAN	zinc finger protein 385A isoform c	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1						GGTGGGAGGCCCCAGCCGAGGG	0.599													7	95					0	0	0.004672	0	0
ITGA5	3678	broad.mit.edu	37	12	54797424	54797424	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:54797424C>T	uc001sga.2	-	17	1829	c.1761G>A	c.(1759-1761)ATG>ATA	p.M587I		NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	587	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						GGTAGATCTTCATCTCTCTGC	0.622													5	53					0	0	0.001168	0	0
ITGA5	3678	broad.mit.edu	37	12	54798523	54798523	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:54798523G>A	uc001sga.2	-	13	1449	c.1381C>T	c.(1381-1383)CGA>TGA	p.R461*	ITGA5_uc010sow.1_RNA	NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	461	Extracellular (Potential).|FG-GAP 7.				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						CGGCCTCCTCGAAGGGCAGAG	0.592											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	51					0	0	0.002450	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54901688	54901688	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:54901688G>A	uc001sgc.3	+	4	437	c.358G>A	c.(358-360)GAT>AAT	p.D120N	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.D70N	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	120					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GTGCCATTTTGATATCGTAAG	0.428													5	74					0	0	0.001168	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54917219	54917219	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:54917219G>A	uc001sgc.3	+	19	1999	c.1920G>A	c.(1918-1920)AAG>AAA	p.K640K	NCKAP1L_uc010sox.1_Silent_p.K182K|NCKAP1L_uc010soy.1_Silent_p.K590K	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	640					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GCAAAGCCAAGAACAAGAAAA	0.498													20	118					0	0	0.002780	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925124	54925124	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:54925124C>T	uc001sgc.3	+	23	2666	c.2587C>T	c.(2587-2589)CAG>TAG	p.Q863*	NCKAP1L_uc010sox.1_Nonsense_Mutation_p.Q405*|NCKAP1L_uc010soy.1_Nonsense_Mutation_p.Q813*	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	863					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TGTGACCTCTCAGATTGTGGA	0.512													15	177					0	0	0.004990	0	0
OR6C70	390327	broad.mit.edu	37	12	55863266	55863266	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:55863266G>A	uc010spn.1	-	1	657	c.657C>T	c.(655-657)ATC>ATT	p.I219I		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	219	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTGTCTTGATGATGTAAGAGT	0.373													20	79					0	0	0.002780	0	0
OR6C68	403284	broad.mit.edu	37	12	55887086	55887086	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:55887086C>T	uc010spo.1	+	1	940	c.940C>T	c.(940-942)CGT>TGT	p.R314C		NM_001005519	NP_001005519	A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AATTGCATTTCGTTTAAAAAA	0.279													7	29					0	0	0.001984	0	0
DGKA	1606	broad.mit.edu	37	12	56346939	56346939	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:56346939C>T	uc001sij.2	+	22	2322	c.2058C>T	c.(2056-2058)ACC>ACT	p.T686T	DGKA_uc001sik.2_Silent_p.T686T|DGKA_uc001sil.2_Silent_p.T686T|DGKA_uc001sim.2_Silent_p.T686T|DGKA_uc001sin.2_Silent_p.T686T|DGKA_uc009zof.2_Silent_p.T332T|DGKA_uc001sio.2_Silent_p.T428T	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	686					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	CTGAGATCACCTTCCAGTAAG	0.567													5	53					0	0	0.000602	0	0
SILV	6490	broad.mit.edu	37	12	56351382	56351382	+	Silent	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:56351382A>G	uc001sip.2	-	6	736	c.705T>C	c.(703-705)AAT>AAC	p.N235N	SILV_uc001siq.2_Silent_p.N235N|SILV_uc010spx.1_Silent_p.N149N|SILV_uc001sir.2_Silent_p.N235N	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	235					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						TCAGAGGCTGATTTCTCAGGA	0.567													8	97					0	0	0.004482	0	0
RAB5B	5869	broad.mit.edu	37	12	56385228	56385228	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:56385228C>T	uc001siv.2	+	5	640	c.523C>T	c.(523-525)CTG>TTG	p.L175L	RAB5B_uc001siw.2_Silent_p.L175L|RAB5B_uc009zog.2_Silent_p.L115L|RAB5B_uc010spz.1_Silent_p.L134L	NM_002868	NP_002859	P61020	RAB5B_HUMAN	RAB5B, member RAS oncogene family	175					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|membrane fraction|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			TGATCTCTTCCTGGCAATAGG	0.458													7	56					0	0	0.006214	0	0
STAT6	6778	broad.mit.edu	37	12	57492326	57492326	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:57492326G>A	uc009zpe.2	-	19	2372	c.2121C>T	c.(2119-2121)TCC>TCT	p.S707S	STAT6_uc009zpf.2_Silent_p.S707S|STAT6_uc001sna.2_Silent_p.S707S|STAT6_uc010srb.1_Silent_p.S597S|STAT6_uc010src.1_Silent_p.S597S|STAT6_uc010srd.1_Silent_p.S597S|STAT6_uc009zpg.2_Silent_p.S756S	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	707					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						ATTCTTCTGGGGAGAGGCCTT	0.542													4	71					0	0	0.000602	0	0
MBD6	114785	broad.mit.edu	37	12	57919277	57919277	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:57919277C>T	uc001soj.1	+	6	750	c.526C>T	c.(526-528)CCC>TCC	p.P176S	MBD6_uc001sok.1_Missense_Mutation_p.P43S|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	176	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCAGGCCTTTCCCACTCTAGC	0.642													5	58					0	0	0.000602	0	0
XRCC6BP1	91419	broad.mit.edu	37	12	58340857	58340857	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:58340857C>T	uc001sqp.2	+	3	353	c.313C>T	c.(313-315)CAG>TAG	p.Q105*		NM_033276	NP_150592	Q9Y6H3	ATP23_HUMAN	XRCC6 binding protein 1	105					double-strand break repair via nonhomologous end joining	DNA-dependent protein kinase-DNA ligase 4 complex	DNA-dependent protein kinase activity|metal ion binding|metalloendopeptidase activity			ovary(1)	1						TTCAACATCTCAGGTAGGCAT	0.383													9	48					0	0	0.006214	0	0
MON2	23041	broad.mit.edu	37	12	62938768	62938768	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:62938768C>T	uc001sre.2	+	21	2948	c.2557C>T	c.(2557-2559)CCT>TCT	p.P853S	MON2_uc009zqj.2_Missense_Mutation_p.P853S|MON2_uc010ssl.1_Missense_Mutation_p.P781S|MON2_uc010ssm.1_Missense_Mutation_p.P830S|MON2_uc010ssn.1_Missense_Mutation_p.P853S|MON2_uc001srf.2_Missense_Mutation_p.P616S	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	854					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TAACCATGATCCTCCACTCTC	0.348													5	32					0	0	0.001168	0	0
TMEM5	10329	broad.mit.edu	37	12	64202716	64202716	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:64202716C>T	uc001srq.1	+	6	1280	c.1176C>T	c.(1174-1176)CTC>CTT	p.L392L	TMEM5_uc001srr.1_Silent_p.L289L|TMEM5_uc001srs.1_Silent_p.L132L	NM_014254	NP_055069	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	392	Extracellular (Potential).					integral to plasma membrane					0		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		GGAAGGAACTCCCTGCTGTTT	0.398													4	42					0	0	0.001168	0	0
RPSAP52	204010	broad.mit.edu	37	12	66151955	66151955	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:66151955G>A	uc001sso.2	-	2	989	c.568C>T	c.(568-570)CCA>TCA	p.P190S		NR_026825				SubName: Full=Putative uncharacterized protein RPSAP52;												0						TGGAGCTGTGGACCAGTCTTC	0.507													3	7					0	0	0.004672	0	0
IL26	55801	broad.mit.edu	37	12	68595632	68595632	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:68595632C>G	uc001stx.1	-	5	544	c.509G>C	c.(508-510)AGT>ACT	p.S170T		NM_018402	NP_060872	Q9NPH9	IL26_HUMAN	interleukin 26 precursor	170					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		GGTTTACTGACTGCTTTCCAA	0.294													4	40					0	0	0.000602	0	0
PTPRB	5787	broad.mit.edu	37	12	70953333	70953333	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:70953333G>A	uc001swb.3	-	16	3880	c.3850C>T	c.(3850-3852)CCC>TCC	p.P1284S	PTPRB_uc010sto.1_Missense_Mutation_p.P1194S|PTPRB_uc010stp.1_Missense_Mutation_p.P1194S|PTPRB_uc001swc.3_Missense_Mutation_p.P1502S|PTPRB_uc001swa.3_Missense_Mutation_p.P1414S|PTPRB_uc001swd.3_Missense_Mutation_p.P1501S|PTPRB_uc009zrr.1_Missense_Mutation_p.P1381S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1284	Fibronectin type-III 15.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CAGTCTGGGGGCCCTTTCCAC	0.478													23	86					0	0	0.014323	0	0
PTPRB	5787	broad.mit.edu	37	12	70954521	70954521	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:70954521C>T	uc001swb.3	-	15	3738	c.3708G>A	c.(3706-3708)AGG>AGA	p.R1236R	PTPRB_uc010sto.1_Silent_p.R1146R|PTPRB_uc010stp.1_Silent_p.R1146R|PTPRB_uc001swc.3_Silent_p.R1454R|PTPRB_uc001swa.3_Silent_p.R1366R|PTPRB_uc001swd.3_Silent_p.R1453R|PTPRB_uc009zrr.1_Silent_p.R1333R	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1236	Fibronectin type-III 14.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GCACGTACTTCCTTCCAGGAA	0.502													4	29					0	0	0.009096	0	0
PTPRB	5787	broad.mit.edu	37	12	70975043	70975044	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:70975043_70975044CC>TT	uc001swb.3	-	8	1726_1727	c.1696_1697GG>AA	c.(1696-1698)GGA>AAA	p.G566K	PTPRB_uc010sto.1_Missense_Mutation_p.G566K|PTPRB_uc010stp.1_Missense_Mutation_p.G476K|PTPRB_uc001swc.3_Missense_Mutation_p.G784K|PTPRB_uc001swa.3_Missense_Mutation_p.G784K|PTPRB_uc001swd.3_Missense_Mutation_p.G783K|PTPRB_uc009zrr.1_Missense_Mutation_p.G663K	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	566	Fibronectin type-III 7.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ACTGGTCATTCCTTGGTTGGCC	0.396													5	39					0	0	0.004672	0	0
TRHDE	29953	broad.mit.edu	37	12	73046898	73046898	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:73046898G>A	uc001sxa.2	+	17	2841	c.2811G>A	c.(2809-2811)TGG>TGA	p.W937*		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	937	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						ACCTTGCCTGGAAGTTTTTCA	0.383													6	35					0	0	0.001984	0	0
GLIPR1L1	256710	broad.mit.edu	37	12	75741450	75741450	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:75741450C>T	uc001sxo.2	+	3	515	c.469C>T	c.(469-471)CCT>TCT	p.P157S	CAPS2_uc001sxm.3_Intron|CAPS2_uc009zsa.2_Intron|GLIPR1L1_uc001sxn.2_Missense_Mutation_p.P157S	NM_152779	NP_689992	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	157						extracellular region					0						TGCAATGTGTCCTAACCTTGG	0.333													6	84					0	0	0.001984	0	0
RASSF9	9182	broad.mit.edu	37	12	86198920	86198920	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:86198920C>T	uc001taf.1	-	2	1207	c.868G>A	c.(868-870)GAG>AAG	p.E290K		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	290	Potential.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						CTTTTTACCTCTTTTTCTATT	0.393													16	107					0	0	0.003163	0	0
TMTC3	160418	broad.mit.edu	37	12	88588803	88588803	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:88588803C>T	uc001tau.2	+	14	2342	c.2122C>T	c.(2122-2124)CTG>TTG	p.L708L		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	709	TPR 8.					integral to membrane	binding			skin(1)	1						TTTGTTTAATCTGGCTCTCCT	0.423													8	24					0	0	0.003080	0	0
ATP2B1	490	broad.mit.edu	37	12	89985051	89985051	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:89985051G>A	uc001tbh.2	-	20	3554	c.3373C>T	c.(3373-3375)CGT>TGT	p.R1125C	ATP2B1_uc001tbg.2_Missense_Mutation_p.S1176L|ATP2B1_uc009zsr.2_RNA|ATP2B1_uc001tbf.2_Missense_Mutation_p.R759C	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	1163	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						AAAGAACTACGAAATGCATTC	0.333													4	18					0	0	0.009096	0	0
C12orf12	196477	broad.mit.edu	37	12	91348334	91348334	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:91348334G>A	uc001tbj.2	-	1	620	c.186C>T	c.(184-186)CCC>CCT	p.P62P		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	62										central_nervous_system(1)|pancreas(1)	2						GCTTCCTTGGGGGCCCATACT	0.662													6	16					0	0	0.001984	0	0
KERA	11081	broad.mit.edu	37	12	91449442	91449442	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:91449442T>A	uc001tbl.2	-	2	1236	c.617A>T	c.(616-618)AAT>ATT	p.N206I		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	206	LRR 6.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						TGGAGGCATATTCCTCAGGGC	0.368													10	85					0	0	0.008291	0	0
KERA	11081	broad.mit.edu	37	12	91449715	91449715	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:91449715C>T	uc001tbl.2	-	2	963	c.344G>A	c.(343-345)GGA>GAA	p.G115E		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	115	LRR 2.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						GCTTAGGGCTCCTTTTTCAAT	0.388													8	65					0	0	0.004482	0	0
KERA	11081	broad.mit.edu	37	12	91449728	91449728	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:91449728C>T	uc001tbl.2	-	2	950	c.331G>A	c.(331-333)GGA>AGA	p.G111R		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	111	LRR 2.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						TTTTCAATTCCGTAGTTGGTT	0.393													8	62					0	0	0.003080	0	0
LUM	4060	broad.mit.edu	37	12	91497959	91497959	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:91497959C>T	uc001tbm.2	-	3	1389	c.1000G>A	c.(1000-1002)GAA>AAA	p.E334K	LUM_uc001tbn.2_RNA	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	334					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						AGAGTGACTTCGTTAGCAACA	0.348													8	39					0	0	0.006214	0	0
PLXNC1	10154	broad.mit.edu	37	12	94673247	94673247	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:94673247G>A	uc001tdc.2	+	22	3847	c.3598_splice	c.e22-1	p.A1200_splice	PLXNC1_uc010sut.1_Splice_Site_p.A247_splice|PLXNC1_uc009zsv.2_Splice_Site	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor						axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						TACTCTTGCAGGCATTAAACG	0.408													4	24					0	0	0.009096	0	0
FGD6	55785	broad.mit.edu	37	12	95604123	95604123	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:95604123G>A	uc001tdp.3	-	2	1161	c.937C>T	c.(937-939)CCA>TCA	p.P313S	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	313					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						TTGGGAGTTGGAAATTTTGGG	0.413													12	93					0	0	0.002450	0	0
USP44	84101	broad.mit.edu	37	12	95927347	95927347	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:95927347G>A	uc001teg.2	-	2	830	c.686C>T	c.(685-687)TCT>TTT	p.S229F	USP44_uc001teh.2_Missense_Mutation_p.S229F|USP44_uc009zte.2_Missense_Mutation_p.S226F	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	229					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						CACCTGAACAGAAACTATTTC	0.403													7	43					0	0	0.003080	0	0
C12orf63	374467	broad.mit.edu	37	12	97133775	97133775	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:97133775C>T	uc001tet.1	+	18	2360	c.2282C>T	c.(2281-2283)TCA>TTA	p.S761L		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	761										skin(6)|ovary(1)	7						CTCCAGGATTCAAAACTTTTT	0.313													4	32					0	0	0.000602	0	0
STAB2	55576	broad.mit.edu	37	12	104042530	104042530	+	Missense_Mutation	SNP	G	A	A	rs139925581	by1000genomes	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:104042530G>A	uc001tjw.2	+	10	1289	c.1103G>A	c.(1102-1104)CGA>CAA	p.R368Q		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	368	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ATTATGGAGCGACTCAGAGAA	0.453													13	73					0	0	0.001855	0	0
STAB2	55576	broad.mit.edu	37	12	104049233	104049233	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:104049233G>A	uc001tjw.2	+	15	1795	c.1609_splice	c.e15-1	p.E537_splice		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor						angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCCAAATGCAGGAAACCAATT	0.373													3	34					0	0	0.000602	0	0
STAB2	55576	broad.mit.edu	37	12	104122639	104122639	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:104122639G>A	uc001tjw.2	+	48	5134	c.4948G>A	c.(4948-4950)GAC>AAC	p.D1650N	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1650	Extracellular (Potential).|FAS1 5.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TAAAGACTGGGACAAATACGG	0.488													5	80					0	0	0.001168	0	0
NUAK1	9891	broad.mit.edu	37	12	106460825	106460825	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:106460825C>T	uc001tlj.1	-	7	3121	c.1741G>A	c.(1741-1743)GAC>AAC	p.D581N		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	581							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						TCAAAAGAGTCGCTGGACAGC	0.597													5	26					0	0	0.000602	0	0
NUAK1	9891	broad.mit.edu	37	12	106461652	106461652	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:106461652C>T	uc001tlj.1	-	7	2294	c.914G>A	c.(913-915)TGG>TAG	p.W305*		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	305	Protein kinase.						ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						CCAGTTCACCCACCAGTGGTT	0.567													7	25					0	0	0.001984	0	0
POLR3B	55703	broad.mit.edu	37	12	106824228	106824229	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:106824228_106824229CC>TT	uc001tlp.2	+	14	1663_1664	c.1441_1442CC>TT	c.(1441-1443)CCT>TTT	p.P481F	POLR3B_uc001tlq.2_Missense_Mutation_p.P423F	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	481					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						AATGCTGTGTCCTTCGGACACT	0.53													6	41					0	0	0.004672	0	0
BTBD11	121551	broad.mit.edu	37	12	108011173	108011173	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:108011173G>A	uc001tmk.1	+	9	2712	c.2191G>A	c.(2191-2193)GAT>AAT	p.D731N	BTBD11_uc009zut.1_Intron|BTBD11_uc001tmj.2_Missense_Mutation_p.D731N|BTBD11_uc001tml.1_Missense_Mutation_p.D268N	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	731	ANK 4.					integral to membrane	DNA binding			skin(2)|ovary(1)	3						CCCCCAGGGTGATATGAACTC	0.473													11	50					0	0	0.010729	0	0
WSCD2	9671	broad.mit.edu	37	12	108589902	108589902	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:108589902G>A	uc001tms.2	+	2	1037	c.293G>A	c.(292-294)GGG>GAG	p.G98E	WSCD2_uc001tmt.2_Missense_Mutation_p.G98E	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	98						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GGCAAGGATGGGAATGAGAGA	0.597													11	52					0	0	0.010729	0	0
DAO	1610	broad.mit.edu	37	12	109292540	109292540	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:109292540G>A	uc001tnr.3	+	9	934	c.781G>A	c.(781-783)GAA>AAA	p.E261K	DAO_uc001tnq.3_Missense_Mutation_p.E195K|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_RNA	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	261					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2						CACCATTTGGGAAGGCTGCTG	0.502													6	35					0	0	0.001168	0	0
ACACB	32	broad.mit.edu	37	12	109625967	109625967	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:109625967C>T	uc001tob.2	+	13	2263	c.2144C>T	c.(2143-2145)TCG>TTG	p.S715L	ACACB_uc001toc.2_Missense_Mutation_p.S715L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	715	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GAGGCCATTTCGTCAGTATCt	0.313													5	37					0	0	0.001168	0	0
MVK	4598	broad.mit.edu	37	12	110032977	110032977	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:110032977C>T	uc001toy.3	+	10	1214	c.1030C>T	c.(1030-1032)CTC>TTC	p.L344F	MVK_uc009zvk.2_Missense_Mutation_p.L344F|MVK_uc010sxr.1_Missense_Mutation_p.L292F|MVK_uc001toz.3_Missense_Mutation_p.L150F|MVK_uc001tpc.3_RNA	NM_001114185	NP_001107657	Q03426	KIME_HUMAN	mevalonate kinase	344					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity				0						CATCACACTCCTCAAGCCAGG	0.617													16	36					0	0	0.004990	0	0
TCTN1	79600	broad.mit.edu	37	12	111085020	111085020	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:111085020C>T	uc009zvs.2	+	13	1607	c.1499C>T	c.(1498-1500)TCC>TTC	p.S500F	TCTN1_uc001trp.3_Missense_Mutation_p.S486F|TCTN1_uc001trn.3_Missense_Mutation_p.S505F|TCTN1_uc001trk.3_RNA|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	500					multicellular organismal development	extracellular region					0						TTGCAGGATTCCTGCCAGCTC	0.388													6	42					0	0	0.004482	0	0
HVCN1	84329	broad.mit.edu	37	12	111099116	111099116	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:111099116C>T	uc001trs.1	-	4	324	c.159G>A	c.(157-159)GAG>GAA	p.E53E	HVCN1_uc001trq.1_Silent_p.E53E|HVCN1_uc001trt.1_Silent_p.E53E|HVCN1_uc010syd.1_Silent_p.E33E	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	53	Cytoplasmic (Potential).|Poly-Glu.				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						GCTGctcctcctcctcctcct	0.522													4	28					0	0	0.009096	0	0
CCDC63	160762	broad.mit.edu	37	12	111317850	111317850	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:111317850G>A	uc001trv.1	+	6	825	c.630G>A	c.(628-630)ATG>ATA	p.M210I	CCDC63_uc009zvt.1_Intron|CCDC63_uc010sye.1_Missense_Mutation_p.M170I|CCDC63_uc001trw.1_Missense_Mutation_p.M125I	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	210										skin(6)|ovary(1)|pancreas(1)	8						AGAAAACCATGAACTTGGCCA	0.527													9	112					0	0	0.008291	0	0
CCDC63	160762	broad.mit.edu	37	12	111336895	111336895	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:111336895G>A	uc001trv.1	+	10	1503	c.1308G>A	c.(1306-1308)GGG>GGA	p.G436G	CCDC63_uc010sye.1_Silent_p.G396G|CCDC63_uc001trw.1_Silent_p.G351G	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	436										skin(6)|ovary(1)|pancreas(1)	8						GGGAGACGGGGAAAGTCACTG	0.473													4	21					0	0	0.000602	0	0
CUX2	23316	broad.mit.edu	37	12	111786100	111786100	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:111786100C>T	uc001tsa.1	+	22	4585	c.4432C>T	c.(4432-4434)CGG>TGG	p.R1478W		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1478						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GGCTGCCAATCGGGAGGAGGC	0.572													8	60					0	0	0.006214	0	0
ACAD10	80724	broad.mit.edu	37	12	112150336	112150336	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:112150336A>G	uc001tsq.2	+	6	925	c.725A>G	c.(724-726)GAA>GGA	p.E242G	ACAD10_uc001tso.3_Missense_Mutation_p.E242G|ACAD10_uc001tsp.2_Missense_Mutation_p.E242G|ACAD10_uc009zvx.2_Missense_Mutation_p.E273G|ACAD10_uc001tsr.2_5'UTR|ACAD10_uc001tss.1_5'Flank	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	242							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						AAGGAATTAGAAGCTCTCTTG	0.388													28	81					0	0	0.009535	0	0
C12orf51	283450	broad.mit.edu	37	12	112686220	112686220	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:112686220G>A	uc009zwc.2	-	19	2799	c.2781C>T	c.(2779-2781)TTC>TTT	p.F927F		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CTTGATATTGGAAATTTATTA	0.378													7	16					0	0	0.001984	0	0
RPH3A	22895	broad.mit.edu	37	12	113307833	113307833	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:113307833G>A	uc010syl.1	+	10	1147	c.785G>A	c.(784-786)CGG>CAG	p.R262Q	RPH3A_uc001ttz.2_Missense_Mutation_p.R262Q|RPH3A_uc001tty.2_Missense_Mutation_p.R258Q|RPH3A_uc009zwe.1_Missense_Mutation_p.R258Q|RPH3A_uc010sym.1_Missense_Mutation_p.R213Q|RPH3A_uc001tua.2_Missense_Mutation_p.R22Q	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	262	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GACTCCAGCCGGAGCCCAGCA	0.532													3	18					0	0	0.009096	0	0
RPH3A	22895	broad.mit.edu	37	12	113314656	113314656	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:113314656G>A	uc010syl.1	+	13	1518	c.1156G>A	c.(1156-1158)GAT>AAT	p.D386N	RPH3A_uc001ttz.2_Missense_Mutation_p.D386N|RPH3A_uc001tty.2_Missense_Mutation_p.D382N|RPH3A_uc009zwe.1_Missense_Mutation_p.D382N|RPH3A_uc010sym.1_Missense_Mutation_p.D337N|RPH3A_uc001tua.2_Missense_Mutation_p.D146N	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	386					intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		CAACAGCTACGATTCGGATGA	0.587													5	26					0	0	0.001168	0	0
MED13L	23389	broad.mit.edu	37	12	116445228	116445228	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:116445228C>T	uc001tvw.2	-	11	2281	c.2226G>A	c.(2224-2226)CTG>CTA	p.L742L		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	742					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TATTCTTTTTCAGGGAATCTT	0.413													6	65					0	0	0.001168	0	0
NOS1	4842	broad.mit.edu	37	12	117660597	117660597	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:117660597C>T	uc001twm.1	-	26	4584	c.3898G>A	c.(3898-3900)GAG>AAG	p.E1300K		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1300					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGCAGGGTCTCTTCCCTGTAG	0.582													10	78					0	0	0.008291	0	0
NOS1	4842	broad.mit.edu	37	12	117768363	117768363	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:117768363G>A	uc001twm.1	-	2	1198	c.512C>T	c.(511-513)TCA>TTA	p.S171L		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	171	Interaction with NOSIP (By similarity).|PIN (nNOS-inhibiting protein) binding.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	ATGGGGGAGTGAGCCAGCCTC	0.667													10	67					0	0	0.006214	0	0
CCDC60	160777	broad.mit.edu	37	12	119978455	119978455	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:119978455G>A	uc001txe.2	+	14	2053	c.1588G>A	c.(1588-1590)GAT>AAT	p.D530N	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	530										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GCCTCAAGAGGATTACATCAG	0.532													5	85					0	0	0.000602	0	0
CIT	11113	broad.mit.edu	37	12	120241180	120241180	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:120241180G>A	uc001txi.1	-	10	1178	c.1125C>T	c.(1123-1125)TTC>TTT	p.F375F	CIT_uc001txh.1_5'UTR|CIT_uc001txj.1_Silent_p.F375F	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	375	AGC-kinase C-terminal.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GGGTGGGAACGAAGGGGGGAG	0.502													7	66					0	0	0.001984	0	0
CABP1	9478	broad.mit.edu	37	12	121098586	121098586	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:121098586C>T	uc001tyu.2	+	4	949	c.882C>T	c.(880-882)CTC>CTT	p.L294L	CABP1_uc001tyv.2_Silent_p.L151L|CABP1_uc001tyw.2_Silent_p.L91L|CABP1_uc001tyx.2_Silent_p.L136L	NM_001033677	NP_001028849	Q9NZU7	CABP1_HUMAN	calcium binding protein 1 isoform 3	294	EF-hand 2.					cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGCCTAAACTCCTGGCAGAGA	0.527													26	253					0	0	0.010818	0	0
UNC119B	84747	broad.mit.edu	37	12	121154822	121154822	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:121154822T>G	uc001tyz.2	+	4	1067	c.620T>G	c.(619-621)TTT>TGT	p.F207C		NM_001080533	NP_001074002	A6NIH7	U119B_HUMAN	unc-119 homolog B	207										haematopoietic_and_lymphoid_tissue(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATCTATGAGTTTCCCCAGCTT	0.463													47	364					0	0	0.014410	0	0
HNF1A	6927	broad.mit.edu	37	12	121426657	121426657	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:121426657G>A	uc001tzg.2	+	2	371	c.348G>A	c.(346-348)GCG>GCA	p.A116A	HNF1A_uc001tze.1_Silent_p.A116A|HNF1A_uc001tzf.2_Silent_p.A116A|HNF1A_uc010szn.1_Silent_p.A116A	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	116					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGCGTGTGGCGAAGATGGTCA	0.627									Hepatic_Adenoma_Familial_Clustering_of				22	171					0	0	0.002780	0	0
C12orf43	64897	broad.mit.edu	37	12	121442889	121442889	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:121442889G>A	uc001tzh.1	-	5	392	c.369C>T	c.(367-369)CGC>CGT	p.R123R	C12orf43_uc009zxa.1_Silent_p.R154R|C12orf43_uc010szo.1_Silent_p.R81R|C12orf43_uc010szp.1_Intron|C12orf43_uc001tzi.1_Silent_p.R123R	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	123											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					tgaagaaaaggcggaaaccta	0.274													15	186					0	0	0.004007	0	0
OASL	8638	broad.mit.edu	37	12	121458587	121458587	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:121458587G>A	uc001tzj.1	-	6	1328	c.1322C>T	c.(1321-1323)CCT>CTT	p.P441L	OASL_uc001tzk.1_3'UTR	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	441	Ubiquitin-like 2.				interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCCACCATCAGGATTCTTCAC	0.532													5	123					0	0	0.001168	0	0
OASL	8638	broad.mit.edu	37	12	121465506	121465506	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:121465506C>T	uc001tzj.1	-	4	778	c.772G>A	c.(772-774)GAA>AAA	p.E258K	OASL_uc001tzk.1_Intron	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	258					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GTGAAGCCTTCGTCCAACATG	0.478													58	369					0	0	0.014410	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481277	123481277	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:123481277G>A	uc001uej.1	-	11	1792	c.1653C>T	c.(1651-1653)TTC>TTT	p.F551F	PITPNM2_uc001uek.1_Silent_p.F551F	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	551					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CCTGCCCATTGAAGGTCATGC	0.637													7	65					0	0	0.003080	0	0
TMED2	10959	broad.mit.edu	37	12	124081261	124081262	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:124081261_124081262CC>TT	uc001ufg.2	+	4	699_700	c.591_592CC>TT	c.(589-594)GTCCGG>GTTTGG	p.R198W		NM_006815	NP_006806	Q15363	TMED2_HUMAN	coated vesicle membrane protein precursor	198	Cytoplasmic (Potential).				protein transport|vesicle-mediated transport	COPI coated vesicle membrane|ER-Golgi intermediate compartment|integral to membrane|microsome|zymogen granule membrane	protein binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000138)|Epithelial(86;0.000613)|all cancers(50;0.00745)		TTTTTGAAGTCCGGAGAGTTGT	0.396													9	48					0	0	0.004672	0	0
DNAH10	196385	broad.mit.edu	37	12	124298348	124298348	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:124298348C>T	uc001uft.3	+	20	3340	c.3315C>T	c.(3313-3315)CTC>CTT	p.L1105L	DNAH10_uc010tav.1_3'UTR|DNAH10_uc010taw.1_3'UTR	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1105	Stem (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTGAAGATCTCAAGTTTGTCC	0.408													4	19					0	0	0.009096	0	0
NCOR2	9612	broad.mit.edu	37	12	124848313	124848314	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:124848313_124848314GG>AA	uc010tba.1	-	21	2956_2957	c.2839_2840CC>TT	c.(2839-2841)CCG>TTG	p.P947L	NCOR2_uc010tay.1_Missense_Mutation_p.P947L|NCOR2_uc010taz.1_Missense_Mutation_p.P930L|NCOR2_uc010tbb.1_Missense_Mutation_p.P947L|NCOR2_uc010tbc.1_Missense_Mutation_p.P929L|NCOR2_uc001ugj.1_Missense_Mutation_p.P947L	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	947					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GTCGCCAGTCGGGGTGAGGAGG	0.713													6	67					0	0	0.004672	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138574	126138574	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:126138574C>T	uc001uhe.1	+	9	2563	c.2555C>T	c.(2554-2556)TCT>TTT	p.S852F	TMEM132B_uc001uhf.1_Missense_Mutation_p.S364F	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	852	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		ACCCCCCAGTCTCCCATGGAA	0.522													5	22					0	0	0.000602	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138647	126138647	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:126138647G>A	uc001uhe.1	+	9	2636	c.2628G>A	c.(2626-2628)GGG>GGA	p.G876G	TMEM132B_uc001uhf.1_Silent_p.G388G	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	876	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCACTCAAGGGAAGTCACCGG	0.512													6	30					0	0	0.001168	0	0
TMEM132D	121256	broad.mit.edu	37	12	129558439	129558439	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:129558439C>T	uc009zyl.1	-	9	3609	c.3281G>A	c.(3280-3282)AGG>AAG	p.R1094K	TMEM132D_uc001uia.2_Missense_Mutation_p.R632K	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	1094	Cytoplasmic (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTCATGTAACCTCTCCATGTA	0.502													7	75					0	0	0.004482	0	0
TMEM132D	121256	broad.mit.edu	37	12	129822269	129822269	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:129822269G>A	uc009zyl.1	-	4	1537	c.1209C>T	c.(1207-1209)GTC>GTT	p.V403V		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	403	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CGGGGTACTCGACCTGCCACG	0.577													14	103					0	0	0.002450	0	0
RIMBP2	23504	broad.mit.edu	37	12	130926844	130926844	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:130926844G>A	uc001uil.2	-	8	1166	c.1002C>T	c.(1000-1002)GTC>GTT	p.V334V	RIMBP2_uc001uim.2_Silent_p.V242V|RIMBP2_uc001uin.1_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	334	Fibronectin type-III 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGTCCACCAGGACGTTGTAGC	0.572													16	59					0	0	0.006122	0	0
GPR133	283383	broad.mit.edu	37	12	131451070	131451070	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:131451070G>A	uc001uit.3	+	3	725	c.166G>A	c.(166-168)GAA>AAA	p.E56K	GPR133_uc010tbm.1_Missense_Mutation_p.E56K	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	56	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGGGATCCATGAACTTCAGGA	0.517													14	46					0	0	0.008871	0	0
NOC4L	79050	broad.mit.edu	37	12	132636059	132636059	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:132636059C>T	uc001ujz.1	+	12	1145	c.1104C>T	c.(1102-1104)TTC>TTT	p.F368F		NM_024078	NP_076983	Q9BVI4	NOC4L_HUMAN	nucleolar complex associated 4 homolog	368					rRNA processing	integral to membrane|nuclear membrane|nucleolus	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.2e-08)|Epithelial(86;3.34e-07)|all cancers(50;1.97e-05)		TGGCCGCCTTCGCCAAGCGGC	0.721													4	19					0	0	0.000602	0	0
POLE	5426	broad.mit.edu	37	12	133233813	133233813	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:133233813G>A	uc001uks.1	-	29	3535	c.3491C>T	c.(3490-3492)CCC>CTC	p.P1164L	POLE_uc001ukr.1_5'UTR|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.P1137L	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1164					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CAGCCAGTCGGGGTGTTTGAC	0.532								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					15	58					0	0	0.004007	0	0
ANKLE2	23141	broad.mit.edu	37	12	133306418	133306418	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:133306418G>A	uc001ukx.2	-	11	2397	c.2330C>T	c.(2329-2331)CCT>CTT	p.P777L	ANKLE2_uc009zyw.1_Missense_Mutation_p.P132L	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	777						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TGCGGGAGAAGGCTCTAACAA	0.478													5	52					0	0	0.000602	0	0
ZNF10	7556	broad.mit.edu	37	12	133732822	133732822	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr12:133732822C>T	uc009zzb.2	+	5	1437	c.990C>T	c.(988-990)TTC>TTT	p.F330F	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Silent_p.F330F	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	330	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GAAAATCCTTCAGCTGGTTCT	0.423													16	45					0	0	0.004990	0	0
LOC284232	284232	broad.mit.edu	37	13	19409578	19409578	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:19409578C>T	uc010tcj.1	-	1		c.36532G>A				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						TGATCATATTCATTCATTAGC	0.289													6	20					0	0	0.001984	0	0
IFT88	8100	broad.mit.edu	37	13	21237654	21237654	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:21237654C>T	uc001unh.2	+	25	2509	c.2113C>T	c.(2113-2115)CGT>TGT	p.R705C	IFT88_uc001uni.2_Missense_Mutation_p.R696C|IFT88_uc001unj.2_Missense_Mutation_p.R695C|IFT88_uc010tcq.1_Missense_Mutation_p.R676C	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	705					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TTTCTTAGTTCGTCTCTGCAC	0.328													4	27					0	0	0.000602	0	0
N6AMT2	221143	broad.mit.edu	37	13	21306032	21306032	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:21306032T>G	uc001uno.1	-	4	537	c.456A>C	c.(454-456)AAA>AAC	p.K152N	N6AMT2_uc009zzr.1_Missense_Mutation_p.K152N|N6AMT2_uc001unp.2_RNA	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	152							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		TTTCCGATGTTTTTCTGAGAC	0.438													5	58					0	0	0.001168	0	0
SAP18	10284	broad.mit.edu	37	13	21715073	21715073	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:21715073C>T	uc001uns.2	+	2	217	c.178C>T	c.(178-180)CAC>TAC	p.H60Y		NM_005870	NP_005861	O00422	SAP18_HUMAN	Sin3A-associated protein, 18kDa	41					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|plasma membrane	protein binding|transcription corepressor activity				0		all_cancers(29;2.16e-20)|all_epithelial(30;2.97e-18)|all_lung(29;4.58e-16)|Lung SC(185;0.0262)|Breast(139;0.147)		all cancers(112;9.79e-05)|Epithelial(112;0.000292)|OV - Ovarian serous cystadenocarcinoma(117;0.00276)|Lung(94;0.0941)		CGGCCGCCACCACCGAATGGA	0.592													13	96					0	0	0.006122	0	0
SGCG	6445	broad.mit.edu	37	13	23869566	23869566	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:23869566C>T	uc001uom.2	+	6	673	c.518C>T	c.(517-519)GCT>GTT	p.A173V	SGCG_uc009zzv.2_Missense_Mutation_p.A173V|SGCG_uc009zzw.2_Missense_Mutation_p.A173V	NM_000231	NP_000222	Q13326	SGCG_HUMAN	gamma sarcoglycan	173	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0		all_cancers(29;4.34e-23)|all_epithelial(30;4.4e-19)|all_lung(29;2.45e-18)|Lung SC(185;0.0228)|Breast(139;0.188)		all cancers(112;0.00255)|Epithelial(112;0.0129)|OV - Ovarian serous cystadenocarcinoma(117;0.0365)|Lung(94;0.205)		CCTGAAGGGGCTCTTTTTGAA	0.378													11	99					0	0	0.013537	0	0
SGCG	6445	broad.mit.edu	37	13	23869617	23869617	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:23869617A>C	uc001uom.2	+	6	724	c.569A>C	c.(568-570)CAA>CCA	p.Q190P	SGCG_uc009zzv.2_Missense_Mutation_p.Q190P|SGCG_uc009zzw.2_Missense_Mutation_p.Q190P	NM_000231	NP_000222	Q13326	SGCG_HUMAN	gamma sarcoglycan	190	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0		all_cancers(29;4.34e-23)|all_epithelial(30;4.4e-19)|all_lung(29;2.45e-18)|Lung SC(185;0.0228)|Breast(139;0.188)		all cancers(112;0.00255)|Epithelial(112;0.0129)|OV - Ovarian serous cystadenocarcinoma(117;0.0365)|Lung(94;0.205)		GACCCGTTTCAAGACCTTAGG	0.423													14	69					0	0	0.004007	0	0
SACS	26278	broad.mit.edu	37	13	23912636	23912636	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:23912636A>C	uc001uon.2	-	10	5968	c.5379T>G	c.(5377-5379)TTT>TTG	p.F1793L	SACS_uc001uoo.2_Missense_Mutation_p.F1646L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1793					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TAGCCATTTCAAAGAGAGCAG	0.443													10	66					0	0	0.008291	0	0
ATP12A	479	broad.mit.edu	37	13	25274926	25274926	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:25274926A>T	uc001upp.2	+	13	1934	c.1747A>T	c.(1747-1749)ACC>TCC	p.T583S	ATP12A_uc010aaa.2_Missense_Mutation_p.T589S	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	583	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GTTTCCAGAAACCTACTCATT	0.438													8	48					0	0	0.008291	0	0
ATP12A	479	broad.mit.edu	37	13	25281459	25281459	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:25281459C>T	uc001upp.2	+	17	2568	c.2381C>T	c.(2380-2382)TCC>TTC	p.S794F	ATP12A_uc010aaa.2_Missense_Mutation_p.S800F	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	794	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ATTGCTTATTCCCTGACCAAG	0.512													10	113					0	0	0.008291	0	0
FAM123A	219287	broad.mit.edu	37	13	25743771	25743772	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:25743771_25743772CC>TT	uc001uqb.2	-	1	2086_2087	c.1986_1987GG>AA	c.(1984-1989)ACGGCC>ACAACC	p.A663T	FAM123A_uc001uqa.2_Missense_Mutation_p.A544T|FAM123A_uc001uqc.2_Missense_Mutation_p.A544T	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	663										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TCGTGGCAGGCCGTTGCTCTGA	0.55													5	51					0	0	0.004672	0	0
FLT1	2321	broad.mit.edu	37	13	29001962	29001962	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:29001962C>T	uc001usb.3	-	9	1488	c.1203G>A	c.(1201-1203)GGG>GGA	p.G401G	FLT1_uc010aar.1_Silent_p.G401G|FLT1_uc001usc.3_Silent_p.G401G|FLT1_uc010tdp.1_Silent_p.G401G	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	401	Ig-like C2-type 4.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TTGTATAATTCCCTGCATCCT	0.393													11	41					0	0	0.010729	0	0
MTUS2	23281	broad.mit.edu	37	13	29600796	29600796	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:29600796C>T	uc001usl.3	+	1	2049	c.1991C>T	c.(1990-1992)GCC>GTC	p.A664V		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	654	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						AATCCCCAGGCCCTGGGCCAG	0.572													4	25					0	0	0.009096	0	0
KL	9365	broad.mit.edu	37	13	33629412	33629412	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:33629412C>T	uc001uus.2	+	3	1567	c.1559C>T	c.(1558-1560)CCC>CTC	p.P520L	KL_uc001uur.1_Missense_Mutation_p.P213L	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	520	Glycosyl hydrolase-1 2.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GGGACATTTCCCTGTGACTTT	0.438													9	50					0	0	0.004482	0	0
KL	9365	broad.mit.edu	37	13	33635004	33635004	+	Silent	SNP	C	T	T	rs141133607		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:33635004C>T	uc001uus.2	+	4	1796	c.1788C>T	c.(1786-1788)TCC>TCT	p.S596S	KL_uc001uur.1_3'UTR	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	596	Glycosyl hydrolase-1 2.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TTCGCTTCTCCCTGGACTGGG	0.532													11	63					0	0	0.010729	0	0
SOHLH2	54937	broad.mit.edu	37	13	36748878	36748878	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:36748878G>A	uc001uvj.2	-	7	859	c.770C>T	c.(769-771)TCT>TTT	p.S257F	SOHLH2_uc010tei.1_Missense_Mutation_p.S334F	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	257					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		AACGGCTGGAGAGATTTTCTC	0.373													5	41					0	0	0.000602	0	0
TRPC4	7223	broad.mit.edu	37	13	38320170	38320170	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:38320170G>A	uc001uws.2	-	3	1036	c.801C>T	c.(799-801)ATC>ATT	p.I267I	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Silent_p.I267I|TRPC4_uc010tey.1_Silent_p.I267I|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Silent_p.I267I|TRPC4_uc010aby.2_Silent_p.I267I	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	267	Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AATTAAGAATGATTTCCAGTT	0.393													14	104					0	0	0.001855	0	0
KBTBD7	84078	broad.mit.edu	37	13	41767060	41767060	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:41767060G>A	uc001uxw.1	-	1	1643	c.1334C>T	c.(1333-1335)CCT>CTT	p.P445L	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	445	Kelch 2.						protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		TCCAGTAATAGGGTCTCGTCC	0.478													18	74					0	0	0.008871	0	0
KIAA0564	23078	broad.mit.edu	37	13	42295550	42295550	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:42295550G>A	uc001uyj.2	-	25	2990	c.2920C>T	c.(2920-2922)CCT>TCT	p.P974S	KIAA0564_uc001uyk.2_Missense_Mutation_p.P974S	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	974						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		GTAGAATAAGGATAGTTAATA	0.433													6	116					0	0	0.001984	0	0
KIAA0564	23078	broad.mit.edu	37	13	42465620	42465620	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:42465620C>T	uc001uyj.2	-	5	657	c.587G>A	c.(586-588)AGA>AAA	p.R196K	KIAA0564_uc001uyk.2_Missense_Mutation_p.R196K	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	196						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		CTGCATCTCTCTGTTTTCCAG	0.453													8	85					0	0	0.003080	0	0
EPSTI1	94240	broad.mit.edu	37	13	43462408	43462408	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:43462408C>T	uc001uyw.1	-	13	1287	c.1211G>A	c.(1210-1212)GGA>GAA	p.G404E	EPSTI1_uc001uyx.1_3'UTR	NM_001002264	NP_001002264	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 isoform 1	Error:Variant_position_missing_in_Q96J88_after_alignment										ovary(1)	1		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		TGTAGCATTTCCCTGGCAGTA	0.408													8	42					0	0	0.003080	0	0
LCP1	3936	broad.mit.edu	37	13	46717441	46717441	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:46717441C>T	uc001vaz.3	-	12	1478	c.1352G>A	c.(1351-1353)GGA>GAA	p.G451E	LCP1_uc010ack.2_5'Flank|LCP1_uc001vay.3_Missense_Mutation_p.G48E|LCP1_uc001vba.3_Missense_Mutation_p.G451E	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	451	Actin-binding 2.|CH 3.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		CATATTGCCTCCCAGTTTGGG	0.438			T	BCL6	NHL 								6	46					0	0	0.006214	0	0
LRCH1	23143	broad.mit.edu	37	13	47315886	47315886	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:47315886C>G	uc001vbj.2	+	19	2326	c.2090C>G	c.(2089-2091)GCC>GGC	p.A697G	LRCH1_uc001vbk.2_Missense_Mutation_p.A732G|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	697										ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		CCAACTTCTGCCCTCCGCTCC	0.498													19	259					0	0	0.007413	0	0
LRCH1	23143	broad.mit.edu	37	13	47315891	47315891	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:47315891C>T	uc001vbj.2	+	19	2331	c.2095C>T	c.(2095-2097)CGC>TGC	p.R699C	LRCH1_uc001vbk.2_Missense_Mutation_p.R734C|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	699										ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TTCTGCCCTCCGCTCCAGGGA	0.498													22	251					0	0	0.014323	0	0
KPNA3	3839	broad.mit.edu	37	13	50307143	50307143	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:50307143G>A	uc001vdj.2	-	3	569	c.154C>T	c.(154-156)CCC>TCC	p.P52S		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3	52	IBB.|Nuclear localization signal (By similarity).				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		TCTTCTTGGGGAACATTTCTC	0.289													4	63					0	0	0.009096	0	0
WDFY2	115825	broad.mit.edu	37	13	52313270	52313270	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:52313270C>T	uc001vfp.2	+	7	1024	c.684C>T	c.(682-684)ATC>ATT	p.I228I	WDFY2_uc010ads.1_Silent_p.I228I|WDFY2_uc010adt.1_RNA	NM_052950	NP_443182	Q96P53	WDFY2_HUMAN	WD repeat and FYVE domain containing 2	228	WD 5.						metal ion binding				0		Breast(56;0.000208)|Lung NSC(96;0.000517)|Prostate(109;0.0041)|Hepatocellular(98;0.0652)|Myeloproliferative disorder(33;0.164)|all_neural(104;0.191)		GBM - Glioblastoma multiforme(99;9e-08)		TGTGGGACATCGGTGGGAGAA	0.517													7	49					0	0	0.001984	0	0
CCDC70	83446	broad.mit.edu	37	13	52439628	52439628	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:52439628G>A	uc001vfu.3	+	2	410	c.114G>A	c.(112-114)CAG>CAA	p.Q38Q	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	38						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		GTATTCGCCAGAAGAAACTAA	0.483													4	48					0	0	0.000602	0	0
ATP7B	540	broad.mit.edu	37	13	52524464	52524464	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:52524464G>A	uc001vfw.2	-	10	2676	c.2519C>T	c.(2518-2520)CCA>CTA	p.P840L	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Missense_Mutation_p.P678L|ATP7B_uc001vfy.2_Missense_Mutation_p.P729L|ATP7B_uc010tgt.1_Missense_Mutation_p.P840L|ATP7B_uc010tgu.1_Missense_Mutation_p.P792L|ATP7B_uc010tgv.1_Missense_Mutation_p.P762L|ATP7B_uc001vfv.2_Missense_Mutation_p.P112L|ATP7B_uc010tgs.1_Missense_Mutation_p.P112L	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	840	Cytoplasmic (Potential).		P -> L (in WD).		ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CCCATCCACTGGAAACTTTCC	0.532									Wilson_disease				10	33					0	0	0.006214	0	0
NEK5	341676	broad.mit.edu	37	13	52676350	52676350	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:52676350G>A	uc001vge.2	-	10	828	c.688C>T	c.(688-690)CGT>TGT	p.R230C	NEK5_uc001vgf.2_Missense_Mutation_p.R230C	NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	230	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		TGGAGCTCACGAGAAAACCCC	0.418													19	145					0	0	0.012319	0	0
THSD1	55901	broad.mit.edu	37	13	52960230	52960230	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:52960230G>C	uc001vgo.2	-	4	1658	c.1113C>G	c.(1111-1113)TTC>TTG	p.F371L	THSD1_uc001vgp.2_Intron|THSD1_uc010tgz.1_5'UTR|THSD1_uc010aea.2_Intron	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	371	Extracellular (Potential).|TSP type-1.					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		GACTGGAGGGGAAGGAAGTGA	0.582													8	68					0	0	0.004482	0	0
PCDH20	64881	broad.mit.edu	37	13	61986932	61986932	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:61986932C>T	uc001vid.3	-	2	1664	c.1300G>A	c.(1300-1302)GAG>AAG	p.E434K	PCDH20_uc010thj.1_Missense_Mutation_p.E434K	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	407	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		CCATCTATCTCGTTTGCTATG	0.418													6	73					0	0	0.001168	0	0
DACH1	1602	broad.mit.edu	37	13	72147041	72147041	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:72147041G>A	uc010thn.1	-	5	1653	c.1230C>T	c.(1228-1230)ACC>ACT	p.T410T	DACH1_uc010tho.1_Intron|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	462					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TATTTGCAATGGTGCTGAGGT	0.443													7	51					0	0	0.006214	0	0
MYCBP2	23077	broad.mit.edu	37	13	77672695	77672695	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:77672695G>A	uc001vkf.2	-	57	8571	c.8480C>T	c.(8479-8481)CCT>CTT	p.P2827L	MYCBP2_uc010aev.2_Missense_Mutation_p.P2231L|MYCBP2_uc001vkg.1_Missense_Mutation_p.P350L|MYCBP2_uc010aew.2_Missense_Mutation_p.P213L	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2827					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACGTTCCCGAGGAGGATCAAG	0.473													6	62					0	0	0.001984	0	0
MYCBP2	23077	broad.mit.edu	37	13	77673139	77673139	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:77673139C>T	uc001vkf.2	-	57	8127	c.8036G>A	c.(8035-8037)GGA>GAA	p.G2679E	MYCBP2_uc010aev.2_Missense_Mutation_p.G2083E|MYCBP2_uc001vkg.1_Missense_Mutation_p.G202E|MYCBP2_uc010aew.2_Missense_Mutation_p.G65E	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2679					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGAGATGTTTCCTCGATCACC	0.368													11	90					0	0	0.010729	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455190	84455190	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:84455190C>T	uc001vlk.2	-	1	1339	c.453G>A	c.(451-453)CAG>CAA	p.Q151Q		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	151	LRR 4.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TGTTCAAGTCCTGGAAGGCCC	0.483													13	54					0	0	0.002450	0	0
GPC5	2262	broad.mit.edu	37	13	92345508	92345508	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:92345508G>A	uc010tif.1	+	3	759	c.393G>A	c.(391-393)AGG>AGA	p.R131R		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	131						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GTACCTACAGGAACATGGCCT	0.418													6	55					0	0	0.001168	0	0
GPC5	2262	broad.mit.edu	37	13	92797201	92797201	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:92797201C>T	uc010tif.1	+	7	1886	c.1520C>T	c.(1519-1521)TCA>TTA	p.S507L		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	507						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TGCGGGGGATCAGGAAGTGGA	0.433													4	15					0	0	0.000602	0	0
NALCN	259232	broad.mit.edu	37	13	101742248	101742248	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:101742248G>A	uc001vox.1	-	29	3528	c.3339C>T	c.(3337-3339)TCC>TCT	p.S1113S		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1113	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGCCTTTCAAGGAGAGAACTT	0.458													24	238					0	0	0.006320	0	0
ITGBL1	9358	broad.mit.edu	37	13	102366796	102366796	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:102366796C>T	uc001vpb.2	+	10	1507	c.1288C>T	c.(1288-1290)CAT>TAT	p.H430Y	ITGBL1_uc010agb.2_Missense_Mutation_p.H381Y|ITGBL1_uc001vpc.3_Missense_Mutation_p.H289Y	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	430	IX.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGGTTCTTGTCATTGTGGGAA	0.413													15	100					0	0	0.006122	0	0
FGF14	2259	broad.mit.edu	37	13	102527575	102527575	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:102527575C>T	uc001vpe.2	-	2	265	c.265G>A	c.(265-267)GGA>AGA	p.G89R	FGF14_uc001vpf.2_Missense_Mutation_p.G94R	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	89					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCGAGAGCTCCATCGGGGTGC	0.448													11	48					0	0	0.013537	0	0
COL4A1	1282	broad.mit.edu	37	13	110829287	110829287	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:110829287C>T	uc001vqw.3	-	34	2936	c.2814G>A	c.(2812-2814)ATG>ATA	p.M938I	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	938	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCACCTTATCCATGGAGCCAG	0.587													11	65					0	0	0.010729	0	0
COL4A1	1282	broad.mit.edu	37	13	110864929	110864929	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:110864929C>T	uc001vqw.3	-	5	438	c.316G>A	c.(316-318)GGA>AGA	p.G106R	COL4A1_uc010agl.2_Missense_Mutation_p.G106R	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	106					angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			ACGGGAAGTCCTGGGTTTCCA	0.493													7	60					0	0	0.003080	0	0
COL4A2	1284	broad.mit.edu	37	13	111138038	111138038	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:111138038G>A	uc001vqx.2	+	34	3351	c.3062G>A	c.(3061-3063)GGA>GAA	p.G1021E		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	1021	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGGCTGTCAGGAATCCCTGGG	0.617													12	45					0	0	0.010729	0	0
ATP11A	23250	broad.mit.edu	37	13	113478715	113478715	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:113478715C>T	uc001vsi.3	+	10	936	c.848C>T	c.(847-849)TCT>TTT	p.S283F	ATP11A_uc001vsj.3_Missense_Mutation_p.S283F|ATP11A_uc001vsm.1_Missense_Mutation_p.S159F	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	283	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CAATCAAAATCTCAGAAGCGA	0.458													9	58					0	0	0.004482	0	0
PROZ	8858	broad.mit.edu	37	13	113814380	113814380	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:113814380G>A	uc001vta.1	+	2	130	c.123G>A	c.(121-123)GCG>GCA	p.A41A	PROZ_uc010agr.1_Silent_p.A63A	NM_003891	NP_003882	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma	41	Gla.				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	GGAAGCGTGCGGGCTCCTATC	0.488													11	123					0	0	0.008291	0	0
PROZ	8858	broad.mit.edu	37	13	113826022	113826022	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:113826022G>A	uc001vta.1	+	8	813	c.806G>A	c.(805-807)TGG>TAG	p.W269*	PROZ_uc010agr.1_Nonsense_Mutation_p.W291*	NM_003891	NP_003882	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma	269	Peptidase S1.				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	GAGCTGGAGTGGCCCATCCAG	0.637													7	58					0	0	0.006214	0	0
GRK1	6011	broad.mit.edu	37	13	114324052	114324052	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr13:114324052C>T	uc010tkf.1	+	2	858	c.750C>T	c.(748-750)ATC>ATT	p.I250I		NM_002929	NP_002920	Q15835	RK_HUMAN	rhodopsin kinase precursor	250	Protein kinase.				regulation of G-protein coupled receptor protein signaling pathway|rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|rhodopsin kinase activity|signal transducer activity			ovary(2)	2	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.234)			GCAGGTTCATCGTGTCTCTGG	0.512													11	145					0	0	0.008291	0	0
POTEG	404785	broad.mit.edu	37	14	19553804	19553804	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:19553804G>A	uc001vuz.1	+	1	440	c.388G>A	c.(388-390)GAG>AAG	p.E130K	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	130										ovary(1)	1						CGCTTTCATGGAGCCGAGGTA	0.592													18	162					0	0	0.004656	0	0
OR4M1	441670	broad.mit.edu	37	14	20249186	20249186	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:20249186C>T	uc010tku.1	+	1	705	c.705C>T	c.(703-705)ACC>ACT	p.T235T		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGAGAATACCAACAGGGCCA	0.468													25	166					0	0	0.003330	0	0
OR4M1	441670	broad.mit.edu	37	14	20249284	20249284	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:20249284C>T	uc010tku.1	+	1	803	c.803C>T	c.(802-804)TCC>TTC	p.S268F		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GACTCATTTTCCCTAGATAAA	0.418													7	117					0	0	0.001984	0	0
OR4N2	390429	broad.mit.edu	37	14	20295961	20295961	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:20295961G>A	uc010tkv.1	+	1	354	c.354G>A	c.(352-354)ATG>ATA	p.M118I		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTGTTGTGATGGCCTTTGACC	0.517													19	163					0	0	0.006122	0	0
OR4K2	390431	broad.mit.edu	37	14	20345023	20345023	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:20345023G>A	uc001vwh.1	+	1	597	c.597G>A	c.(595-597)ATG>ATA	p.M199I		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCCTCTTTATGATCTCAACAA	0.403													29	290					0	0	0.005443	0	0
OR4K5	79317	broad.mit.edu	37	14	20389069	20389069	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:20389069T>A	uc010tkw.1	+	1	304	c.304T>A	c.(304-306)TTC>ATC	p.F102I		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGCCCAAATTTTCTTTATTCA	0.418													8	213					0	0	0.003080	0	0
OR4K1	79544	broad.mit.edu	37	14	20404557	20404557	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:20404557C>T	uc001vwj.1	+	1	732	c.732C>T	c.(730-732)ATC>ATT	p.I244I		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CTGCCCACATCACAGTGGTCA	0.418													7	77					0	0	0.001984	0	0
OR11G2	390439	broad.mit.edu	37	14	20666407	20666407	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:20666407G>A	uc010tlb.1	+	1	913	c.913G>A	c.(913-915)GAA>AAA	p.E305K		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	305	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		atctaagaatgaagctggaaa	0.264													14	83					0	0	0.001855	0	0
OR11H6	122748	broad.mit.edu	37	14	20691973	20691973	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:20691973C>T	uc010tlc.1	+	1	105	c.105C>T	c.(103-105)TTC>TTT	p.F35F		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	35	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TCCTGGGTTTCCATGGTCAAA	0.423													34	114					0	0	0.006230	0	0
OR11H6	122748	broad.mit.edu	37	14	20692800	20692800	+	Missense_Mutation	SNP	G	A	A	rs143225754	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:20692800G>A	uc010tlc.1	+	1	932	c.932G>A	c.(931-933)CGA>CAA	p.R311Q		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TATAGTCTTCGAAACAAAGAC	0.423													6	75					0	0	0.003080	0	0
OR11H4	390442	broad.mit.edu	37	14	20711877	20711877	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:20711877C>T	uc010tld.1	+	1	927	c.927C>T	c.(925-927)CTC>CTT	p.L309L		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		ACATGAAACTCGCTCTGAGAA	0.393													5	57					0	0	0.001168	0	0
RNASE9	390443	broad.mit.edu	37	14	21024712	21024712	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:21024712C>T	uc010aho.2	-	4	676	c.517G>A	c.(517-519)GAA>AAA	p.E173K	RNASE9_uc001vxq.3_Missense_Mutation_p.E178K|RNASE9_uc010ahp.2_Missense_Mutation_p.E178K|RNASE9_uc010ahq.2_Missense_Mutation_p.E178K|RNASE9_uc010ahr.2_Missense_Mutation_p.E178K|RNASE9_uc010ahs.2_Missense_Mutation_p.E173K|RNASE9_uc010aht.2_Missense_Mutation_p.E173K|RNASE9_uc010ahu.2_Missense_Mutation_p.E173K	NM_001110357	NP_001103827	P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	173						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(2)	2	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		TTTTGCATTTCATTTTGCCAT	0.388													4	20					0	0	0.009096	0	0
OR5AU1	390445	broad.mit.edu	37	14	21623357	21623357	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:21623357G>A	uc010tlp.1	-	1	828	c.828C>T	c.(826-828)ATC>ATT	p.I276I		NM_001004731	NP_001004731	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU,	276	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		TCATTTTCAGGATGGTGTTGA	0.473													6	17					0	0	0.001984	0	0
SALL2	6297	broad.mit.edu	37	14	21991685	21991685	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:21991685G>A	uc001wbe.2	-	2	2459	c.2177C>T	c.(2176-2178)CCT>CTT	p.P726L	SALL2_uc010tly.1_Missense_Mutation_p.P724L|SALL2_uc010tlz.1_Missense_Mutation_p.P589L|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Missense_Mutation_p.P591L|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	726							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		TCCACCTTCAGGGAGTGCAGT	0.607													3	43					0	0	0.004672	0	0
OR10G3	26533	broad.mit.edu	37	14	22038555	22038555	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:22038555G>A	uc010tmb.1	-	1	321	c.321C>T	c.(319-321)TTC>TTT	p.F107F		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		TGCTGCCCAGGAAGTGATAGA	0.512													5	24					0	0	0.000602	0	0
OR10G2	26534	broad.mit.edu	37	14	22102706	22102706	+	Missense_Mutation	SNP	G	A	A	rs112202933	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:22102706G>A	uc010tmc.1	-	1	293	c.293C>T	c.(292-294)CCG>CTG	p.P98L		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		GCCACCAAACGGGATAGCCTT	0.493													6	38					0	0	0.001984	0	0
OR4E2	26686	broad.mit.edu	37	14	22133973	22133973	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:22133973G>A	uc010tmd.1	+	1	677	c.677G>A	c.(676-678)CGA>CAA	p.R226Q		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		GTTTCTCTTCGAAAACACTCA	0.502													15	40					0	0	0.004007	0	0
HAUS4	54930	broad.mit.edu	37	14	23416932	23416932	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:23416932G>A	uc001whp.2	-	7	748	c.717C>T	c.(715-717)CTC>CTT	p.L239L	HAUS4_uc001who.2_RNA|HAUS4_uc001whq.2_Silent_p.L113L|HAUS4_uc001whr.2_Silent_p.L239L|HAUS4_uc001whs.2_Silent_p.L194L|HAUS4_uc001wht.2_Silent_p.L239L|HAUS4_uc001whu.2_Silent_p.L194L|HAUS4_uc001whv.2_Silent_p.L115L|HAUS4_uc001whw.2_Silent_p.L239L|HAUS4_uc001whx.2_Silent_p.L194L	NM_017815	NP_060285	Q9H6D7	HAUS4_HUMAN	HAUS augmin-like complex, subunit 4	239					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				ovary(1)	1						TGAGGCAGCGGAGAAGCACCT	0.502													6	57					0	0	0.001984	0	0
PSMB11	122706	broad.mit.edu	37	14	23511855	23511855	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:23511855G>A	uc010ake.1	+	1	480	c.421G>A	c.(421-423)GGA>AGA	p.G141R		NM_001099780	NP_001093250	A5LHX3	PSB11_HUMAN	proteasome beta 11 subunit precursor	141					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)		TCAATACCGGGGACTGGATCT	0.627													7	59					0	0	0.006214	0	0
CDH24	64403	broad.mit.edu	37	14	23522741	23522741	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:23522741G>A	uc001wil.2	-	7	1450	c.1190C>T	c.(1189-1191)TCC>TTC	p.S397F	CDH24_uc010akf.2_Missense_Mutation_p.S397F|CDH24_uc001win.3_Missense_Mutation_p.S397F	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	397	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GTCAGCCGCGGAGATCTGGCC	0.642													4	31					0	0	0.009096	0	0
EFS	10278	broad.mit.edu	37	14	23829435	23829435	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:23829435C>T	uc001wjo.2	-	3	961	c.353G>A	c.(352-354)GGA>GAA	p.G118E	EFS_uc001wjp.2_Missense_Mutation_p.G25E|EFS_uc010tnm.1_Missense_Mutation_p.G25E	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	118	Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		TGGGCAAGGTCCAGCTGGAGG	0.622													8	67					0	0	0.004482	0	0
MYH6	4624	broad.mit.edu	37	14	23855235	23855235	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:23855235C>T	uc001wjv.2	-	34	5132	c.5065G>A	c.(5065-5067)GAG>AAG	p.E1689K		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1689	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCACGCAGCTCCTCCAGCTCA	0.647													10	30					0	0	0.008291	0	0
MYH6	4624	broad.mit.edu	37	14	23866823	23866823	+	Splice_Site	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:23866823C>T	uc001wjv.2	-	16	1959	c.1892_splice	c.e16-1	p.G631_splice		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6						adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCACTGTCCCCTAAACAGCGA	0.343													8	52					0	0	0.006214	0	0
MYH6	4624	broad.mit.edu	37	14	23874910	23874910	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:23874910C>T	uc001wjv.2	-	4	338	c.271G>A	c.(271-273)GCC>ACC	p.A91T	MYH6_uc010akp.1_Missense_Mutation_p.A91T	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	91	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GTCAGCATGGCCATGTCCTCA	0.577													7	53					0	0	0.003080	0	0
MYH7	4625	broad.mit.edu	37	14	23899822	23899822	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:23899822C>T	uc001wjx.2	-	11	1052	c.946G>A	c.(946-948)GGA>AGA	p.G316R		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	316	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GTGGTCTCTCCTTGGGAGATG	0.562													6	32					0	0	0.003080	0	0
DHRS2	10202	broad.mit.edu	37	14	24108413	24108413	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:24108413C>T	uc001wkt.3	+	3	613	c.166C>T	c.(166-168)CTG>TTG	p.L56L	DHRS2_uc010aku.1_Silent_p.L56L|DHRS2_uc001wku.3_Silent_p.L56L|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Silent_p.L56L	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	34	NAD or NADP (By similarity).				C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		CGCCCGACGTCTGGCCCGGGA	0.642													9	118					0	0	0.013537	0	0
RNF31	55072	broad.mit.edu	37	14	24620496	24620496	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:24620496T>C	uc001wmn.1	+	9	1894	c.1645T>C	c.(1645-1647)TTT>CTT	p.F549L	RNF31_uc001wml.1_Missense_Mutation_p.F398L|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Intron|RNF31_uc001wmo.1_Missense_Mutation_p.F16L|RNF31_uc001wmp.2_RNA	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	549					CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GCTGGGTGCCTTTTCCTGTCA	0.617													3	46					0	0	0.004672	0	0
TGM1	7051	broad.mit.edu	37	14	24723876	24723876	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:24723876G>A	uc001wod.2	-	13	2206	c.2082C>T	c.(2080-2082)TCC>TCT	p.S694S	TGM1_uc010tog.1_Silent_p.S252S	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	694					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TCACCGTGAGGGAGAGGTCTG	0.627													14	54					0	0	0.004007	0	0
RIPK3	11035	broad.mit.edu	37	14	24808479	24808479	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:24808479G>A	uc001wpb.2	-	3	423	c.213C>T	c.(211-213)TTC>TTT	p.F71F	RIPK3_uc001wpa.2_5'Flank|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_5'UTR|RIPK3_uc010toj.1_Silent_p.F71F	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	71	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		GGCGCAGCACGAATTCGTTAT	0.567													9	77					0	0	0.008291	0	0
CBLN3	643866	broad.mit.edu	37	14	24897149	24897149	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:24897149G>A	uc001wpg.3	-	3	935	c.464C>T	c.(463-465)GCC>GTC	p.A155V	KHNYN_uc010tpc.1_5'Flank|KHNYN_uc001wph.3_5'Flank|KHNYN_uc010alw.2_5'Flank	NM_001039771	NP_001034860	Q6UW01	CBLN3_HUMAN	cerebellin 3 precursor	155	Necessary for interaction with CBLN3, and homotrimerization (By similarity).|C1q.					cell junction|extracellular region|synapse				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(265;0.00159)		AGGATCATTGGCAAAGGCTGA	0.637													6	36					0	0	0.001168	0	0
NOVA1	4857	broad.mit.edu	37	14	26917315	26917315	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:26917315G>A	uc001wpy.2	-	5	1692	c.1374C>T	c.(1372-1374)TCC>TCT	p.S458S	NOVA1_uc001wpz.2_Silent_p.S434S|NOVA1_uc001wqa.2_Silent_p.S336S	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	461	KH 3.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		CTCCTTTTTTGGAGATCTGTA	0.428													6	27					0	0	0.001168	0	0
SCFD1	23256	broad.mit.edu	37	14	31191711	31191711	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:31191711T>G	uc001wqm.1	+	23	1806	c.1782T>G	c.(1780-1782)TTT>TTG	p.F594L	SCFD1_uc001wqn.1_Missense_Mutation_p.F527L|SCFD1_uc010tpg.1_Missense_Mutation_p.F535L|SCFD1_uc010tph.1_Missense_Mutation_p.F409L|SCFD1_uc010amf.1_Missense_Mutation_p.F409L|SCFD1_uc010tpi.1_Missense_Mutation_p.F502L|SCFD1_uc010ame.1_Missense_Mutation_p.L516W	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	594					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		CCATTGTTTTTGTGGTGGGAG	0.303													4	66					0	0	0.009096	0	0
AKAP6	9472	broad.mit.edu	37	14	33293203	33293203	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:33293203G>A	uc001wrq.2	+	13	6354	c.6184G>A	c.(6184-6186)GAA>AAA	p.E2062K		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2062					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CTTTGTTAAGGAAATCATTGA	0.398													5	38					0	0	0.001168	0	0
MBIP	51562	broad.mit.edu	37	14	36784011	36784011	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:36784011G>A	uc001wtm.2	-	3	448	c.360C>T	c.(358-360)TCC>TCT	p.S120S	MBIP_uc001wto.2_Silent_p.S120S|MBIP_uc010tpy.1_Missense_Mutation_p.P5L|MBIP_uc001wtn.2_Silent_p.S120S	NM_016586	NP_057670	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1 isoform 1	120					histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		GGTCGCCAATGGAAAATTTGT	0.363													8	79					0	0	0.003080	0	0
CLEC14A	161198	broad.mit.edu	37	14	38723952	38723952	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:38723952G>A	uc001wum.1	-	1	1623	c.1276C>T	c.(1276-1278)CAC>TAC	p.H426Y		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	426	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GGGCTTTCGTGAAAGCAGAGC	0.562													5	33					0	0	0.001168	0	0
PNN	5411	broad.mit.edu	37	14	39650383	39650383	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:39650383C>T	uc001wuw.3	+	9	1567	c.1470C>T	c.(1468-1470)TCC>TCT	p.S490S		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	490	Gln-rich.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		aatcccagtcccaaccAGTAC	0.363													7	50					0	0	0.001984	0	0
RPL10L	140801	broad.mit.edu	37	14	47120418	47120418	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:47120418C>T	uc001wwg.2	-	1	611	c.522G>A	c.(520-522)ACG>ACA	p.T174T		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	174					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						CATTAAACTTCGTGAAGCCCC	0.507													13	69					0	0	0.003163	0	0
SAV1	60485	broad.mit.edu	37	14	51132059	51132059	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:51132059C>T	uc001wyg.1	-	3	534	c.373G>A	c.(373-375)GAA>AAA	p.E125K	SAV1_uc001wyh.1_Missense_Mutation_p.E125K	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	WW45 protein	125					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)	1	all_epithelial(31;0.000611)|Breast(41;0.0333)					TCTCCATTTTCAACAGCAAAA	0.408													5	25					0	0	0.001168	0	0
PYGL	5836	broad.mit.edu	37	14	51378726	51378726	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:51378726G>A	uc001wyu.2	-	15	1924	c.1797C>T	c.(1795-1797)TTC>TTT	p.F599F	PYGL_uc010tqq.1_Silent_p.F565F|PYGL_uc001wyv.2_Silent_p.F273F	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	599					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TCCTTGGCACGAATAACTTCT	0.433													10	51					0	0	0.008291	0	0
NID2	22795	broad.mit.edu	37	14	52478331	52478331	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:52478331C>T	uc001wzo.2	-	17	3725	c.3491G>A	c.(3490-3492)CGG>CAG	p.R1164Q	NID2_uc010tqs.1_Missense_Mutation_p.R1116Q|NID2_uc010tqt.1_Missense_Mutation_p.R1164Q	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1164	LDL-receptor class B 1.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GCTGATTGTCCGTCCAGCAAC	0.488													12	65					0	0	0.010729	0	0
TXNDC16	57544	broad.mit.edu	37	14	52985926	52985926	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:52985926T>A	uc001wzs.2	-	7	927	c.478A>T	c.(478-480)ATT>TTT	p.I160F	TXNDC16_uc010tqu.1_Missense_Mutation_p.I155F|TXNDC16_uc010aoe.2_RNA	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1	160					cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					GAGAATATAATATTTGCTTTT	0.323													6	54					0	0	0.001984	0	0
ERO1L	30001	broad.mit.edu	37	14	53149100	53149100	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:53149100G>A	uc001wzv.2	-	3	487	c.261C>T	c.(259-261)TTC>TTT	p.F87F	ERO1L_uc001wzw.2_RNA|ERO1L_uc010aof.2_RNA	NM_014584	NP_055399	Q96HE7	ERO1A_HUMAN	ERO1-like precursor	87					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor				0	Breast(41;0.226)					TGTCATTCCAGAAAGGACACG	0.323													13	50					0	0	0.004007	0	0
FERMT2	10979	broad.mit.edu	37	14	53340905	53340905	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:53340905T>C	uc001xad.2	-	9	1193	c.1138A>G	c.(1138-1140)AAA>GAA	p.K380E	FERMT2_uc001xac.2_Missense_Mutation_p.K380E|FERMT2_uc001xae.2_Missense_Mutation_p.K380E|FERMT2_uc001xaf.2_Missense_Mutation_p.K380E	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	380	FERM.|PH.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					TTGAAAACTTTAATGTAGTCA	0.299													6	32					0	0	0.001984	0	0
ARID4A	5926	broad.mit.edu	37	14	58825899	58825899	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:58825899G>A	uc001xdp.2	+	18	2157	c.1903G>A	c.(1903-1905)GGT>AGT	p.G635S	ARID4A_uc001xdo.2_Missense_Mutation_p.G635S|ARID4A_uc001xdq.2_Missense_Mutation_p.G635S|ARID4A_uc010apg.1_Missense_Mutation_p.G313S	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	635					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						TTTGGACAAAGGTGGACCAAA	0.289													12	41					0	0	0.004007	0	0
DACT1	51339	broad.mit.edu	37	14	59113692	59113693	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:59113692_59113693GG>AA	uc001xdw.2	+	4	2515_2516	c.2351_2352GG>AA	c.(2350-2352)TGG>TAA	p.W784*	DACT1_uc010trv.1_Nonsense_Mutation_p.W503*|DACT1_uc001xdx.2_Nonsense_Mutation_p.W747*|DACT1_uc010trw.1_Nonsense_Mutation_p.W503*	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	784					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						GGCTTAATTTGGTCCCAGTTTG	0.55													5	65					0	0	0.004672	0	0
C14orf39	317761	broad.mit.edu	37	14	60903741	60903741	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:60903741C>T	uc001xez.3	-	18	1696	c.1586G>A	c.(1585-1587)GGA>GAA	p.G529E	C14orf39_uc010apo.2_Missense_Mutation_p.G240E	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	529										ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		GCCATCTTCTCCTTCTGGCTT	0.313													17	103					0	0	0.007413	0	0
SIX4	51804	broad.mit.edu	37	14	61180413	61180413	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:61180413C>T	uc001xfc.2	-	3	2058	c.2058G>A	c.(2056-2058)GGG>GGA	p.G686G		NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	sine oculis homeobox homolog 4	686						nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		GAACTATTTCCCCAAGGGCAG	0.473													6	35					0	0	0.001984	0	0
PRKCH	5583	broad.mit.edu	37	14	62016441	62016441	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:62016441C>T	uc001xfn.2	+	14	2249	c.1944C>T	c.(1942-1944)TTC>TTT	p.F648F	PRKCH_uc010tsa.1_Silent_p.F487F|PRKCH_uc010tsb.1_Silent_p.F216F|PRKCH_uc001xfo.2_RNA	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	648	AGC-kinase C-terminal.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		ACCCTGACTTCATAAAGGAAG	0.398													18	83					0	0	0.010504	0	0
KCNH5	27133	broad.mit.edu	37	14	63453887	63453887	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:63453887C>T	uc001xfx.2	-	5	503	c.452G>A	c.(451-453)CGA>CAA	p.R151Q	KCNH5_uc001xfy.2_Missense_Mutation_p.R151Q|KCNH5_uc001xfz.1_Missense_Mutation_p.R93Q|KCNH5_uc001xga.2_Missense_Mutation_p.R93Q	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	151	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CCGTGTCAATCGGGCAAATTT	0.378													9	64					0	0	0.004482	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65208571	65208571	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:65208571C>T	uc001xho.1	+	16	2605	c.2336C>T	c.(2335-2337)TCC>TTC	p.S779F	PLEKHG3_uc001xhn.1_Missense_Mutation_p.S723F|PLEKHG3_uc001xhp.2_Missense_Mutation_p.S900F|PLEKHG3_uc010aqh.1_Missense_Mutation_p.S321F|PLEKHG3_uc001xhq.1_Missense_Mutation_p.S284F	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	779					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CAGGTGGGCTCCCGGCCGACT	0.607													6	63					0	0	0.001984	0	0
SPTB	6710	broad.mit.edu	37	14	65239436	65239436	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:65239436C>T	uc001xht.2	-	25	5469	c.5415G>A	c.(5413-5415)ACG>ACA	p.T1805T	SPTB_uc001xhr.2_Silent_p.T1805T|SPTB_uc001xhs.2_Silent_p.T1805T|SPTB_uc001xhu.2_Silent_p.T1805T|SPTB_uc010aqi.2_Silent_p.T466T	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1805	Spectrin 15.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TCTCGGCACCCGTGTAGAAGT	0.657													11	55					0	0	0.008291	0	0
EXD2	55218	broad.mit.edu	37	14	69697274	69697274	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:69697274C>T	uc001xkt.2	+	6	960	c.301C>T	c.(301-303)CGT>TGT	p.R101C	EXD2_uc001xku.2_5'UTR|EXD2_uc001xkv.2_Missense_Mutation_p.R226C|EXD2_uc001xkw.2_Missense_Mutation_p.R101C|EXD2_uc001xkx.2_RNA|EXD2_uc010aqt.2_Missense_Mutation_p.R226C|EXD2_uc010tte.1_Missense_Mutation_p.R226C|EXD2_uc001xky.2_Missense_Mutation_p.R101C	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	101	3'-5' exonuclease.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						CCTTCTACTTCGTTGCAGCAA	0.408													9	71					0	0	0.006214	0	0
EXD2	55218	broad.mit.edu	37	14	69701570	69701570	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:69701570C>T	uc001xkt.2	+	7	1155	c.496C>T	c.(496-498)CCA>TCA	p.P166S	EXD2_uc001xku.2_Missense_Mutation_p.P36S|EXD2_uc001xkv.2_Missense_Mutation_p.P291S|EXD2_uc001xkw.2_Missense_Mutation_p.P166S|EXD2_uc010aqt.2_Missense_Mutation_p.P291S|EXD2_uc010tte.1_Missense_Mutation_p.P291S|EXD2_uc001xky.2_Missense_Mutation_p.P166S	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	166					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						GGTCGACATCCCATTTCGAAG	0.443													7	38					0	0	0.003080	0	0
SLC8A3	6547	broad.mit.edu	37	14	70633878	70633878	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:70633878T>A	uc001xly.2	-	2	2016	c.1262A>T	c.(1261-1263)AAA>ATA	p.K421I	SLC8A3_uc001xlw.2_Missense_Mutation_p.K421I|SLC8A3_uc001xlx.2_Missense_Mutation_p.K421I|SLC8A3_uc001xlz.2_Missense_Mutation_p.K421I|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	421	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GTCTCCCCCTTTCCTCACCAC	0.507													5	63					0	0	0.001984	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713723	70713723	+	Missense_Mutation	SNP	C	T	T	rs72159324		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:70713723C>T	uc010ttg.1	-	1	796	c.145G>A	c.(145-147)GAT>AAT	p.D49N		NR_003951				SubName: Full=ADAM21-like protein;												0						ATGAAGAAATCATGGTTCACC	0.423													6	59					0	0	0.001984	0	0
PCNX	22990	broad.mit.edu	37	14	71428979	71428979	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:71428979C>T	uc001xmo.2	+	3	845	c.399C>T	c.(397-399)ATC>ATT	p.I133I	PCNX_uc001xmn.3_Silent_p.I133I|PCNX_uc010are.1_Silent_p.I133I	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	133						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CTGAGTTCATCCGAGAGGCCA	0.443													23	105					0	0	0.003954	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72190486	72190486	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:72190486C>T	uc001xms.2	+	16	4742	c.4394C>T	c.(4393-4395)TCC>TTC	p.S1465F	SIPA1L1_uc001xmt.2_Missense_Mutation_p.S1444F|SIPA1L1_uc001xmu.2_Missense_Mutation_p.S1444F|SIPA1L1_uc001xmv.2_Missense_Mutation_p.S1465F|SIPA1L1_uc010ttm.1_Missense_Mutation_p.S919F|SIPA1L1_uc001xmw.2_Missense_Mutation_p.S230F	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1465	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		tcctcttcctcctcctcctcT	0.468													6	65					0	0	0.001168	0	0
RGS6	9628	broad.mit.edu	37	14	72939610	72939610	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:72939610G>A	uc001xna.3	+	9	1090	c.567G>A	c.(565-567)AGG>AGA	p.R189R	RGS6_uc010ttn.1_Silent_p.R189R|RGS6_uc001xmx.3_Silent_p.R189R|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Silent_p.R189R|RGS6_uc010ttp.1_Silent_p.R120R|RGS6_uc001xmz.1_Silent_p.R50R|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	189					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		AGACAGAAAGGAAAATTTTGG	0.398													39	111					0	0	0.014410	0	0
HEATR4	399671	broad.mit.edu	37	14	73985814	73985814	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:73985814C>T	uc010tub.1	-	5	1445	c.1123G>A	c.(1123-1125)GAA>AAA	p.E375K	HEATR4_uc010tua.1_Missense_Mutation_p.E328K	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TTTAGGTTTTCCAGGACAATC	0.453													11	52					0	0	0.013537	0	0
ACOT2	10965	broad.mit.edu	37	14	74036061	74036061	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:74036061G>A	uc001xon.3	+	1	290	c.117G>A	c.(115-117)AAG>AAA	p.K39K	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_Missense_Mutation_p.E5K	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	39					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		GGAGCCTGAAGAGTTCGGCGC	0.582													15	89					0	0	0.003163	0	0
FAM161B	145483	broad.mit.edu	37	14	74411155	74411155	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:74411155C>T	uc001xpd.1	-	3	914	c.808G>A	c.(808-810)GAA>AAA	p.E270K		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						CGAGCAGCTTCCTTTAGCTGC	0.567													7	43					0	0	0.001984	0	0
TMEM90A	646658	broad.mit.edu	37	14	74874331	74874331	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:74874331G>A	uc001xpx.2	-	4	872	c.624C>T	c.(622-624)TTC>TTT	p.F208F		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	208	Helical; (Potential).				response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		GTGTGGCTAGGAAGAGGGCCC	0.627													13	59					0	0	0.003163	0	0
LTBP2	4053	broad.mit.edu	37	14	75016635	75016635	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:75016635C>T	uc001xqa.2	-	8	2107	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	574	TB 1.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CAGCAGTCCTCCTGGGTAGTC	0.617													11	47					0	0	0.010729	0	0
YLPM1	56252	broad.mit.edu	37	14	75247204	75247204	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:75247204C>T	uc001xqj.3	+	3	1331	c.1207C>T	c.(1207-1209)CAG>TAG	p.Q403*	YLPM1_uc001xql.3_5'Flank	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		TTTCCAGTATCAGGGAATAAT	0.493													15	79					0	0	0.004007	0	0
YLPM1	56252	broad.mit.edu	37	14	75283748	75283748	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:75283748A>T	uc001xqj.3	+	14	5924	c.5800A>T	c.(5800-5802)ATC>TTC	p.I1934F	YLPM1_uc001xql.3_RNA|YLPM1_uc001xqm.1_Missense_Mutation_p.I417F	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1739					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCTGGATGCCATCAATGACAG	0.408													6	17					0	0	0.004482	0	0
ESRRB	2103	broad.mit.edu	37	14	76928939	76928939	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:76928939G>A	uc001xsq.1	+	3	516	c.449G>A	c.(448-450)CGG>CAG	p.R150Q	ESRRB_uc001xsr.2_Missense_Mutation_p.R150Q|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	150						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		ATCACCAAACGGAGGCGCAAG	0.617													7	82					0	0	0.001984	0	0
ESRRB	2103	broad.mit.edu	37	14	76967055	76967055	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:76967055C>T	uc001xsr.2	+	11	1889	c.1518C>T	c.(1516-1518)CTC>CTT	p.L506L	ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	Error:Variant_position_missing_in_A2VDJ2_after_alignment						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		ATCTCTGGCTCACCATGTAAC	0.567													11	72					0	0	0.013537	0	0
KIAA1737	85457	broad.mit.edu	37	14	77580245	77580245	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:77580245C>T	uc001xtd.2	+	4	963	c.784C>T	c.(784-786)CCC>TCC	p.P262S	KIAA1737_uc001xtc.1_Missense_Mutation_p.P164S	NM_033426	NP_219494	Q9C0C6	K1737_HUMAN	KIAA1737 protein	262											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0284)		CTTCGCTTCCCCCGCCAGTCC	0.572													14	41					0	0	0.001855	0	0
DIO2	1734	broad.mit.edu	37	14	80669237	80669237	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:80669237G>A	uc010tvq.1	-	4	1019	c.617C>T	c.(616-618)CCC>CTC	p.P206L	DIO2_uc010tvp.1_Missense_Mutation_p.P242L|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_3'UTR|DIO2_uc010tvr.1_Missense_Mutation_p.P206L|DIO2_uc010asy.2_3'UTR	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	206					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		TCGGCACTGGGGCGGCAAGGA	0.542											OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	56					0	0	0.013537	0	0
STON2	85439	broad.mit.edu	37	14	81744852	81744852	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:81744852T>A	uc010tvu.1	-	4	1004	c.803A>T	c.(802-804)AAT>ATT	p.N268I	STON2_uc001xvk.1_Missense_Mutation_p.N268I|STON2_uc010tvt.1_Missense_Mutation_p.N65I	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	268					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TCCCATTGAATTATAAGGTAC	0.448													18	79					0	0	0.007413	0	0
KCNK10	54207	broad.mit.edu	37	14	88651909	88651909	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:88651909C>T	uc001xwo.2	-	7	2044	c.1587G>A	c.(1585-1587)GAG>GAA	p.E529E	KCNK10_uc001xwm.2_Silent_p.E534E|KCNK10_uc001xwn.2_Silent_p.E534E	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	529	Cytoplasmic (Potential).			E -> G (in Ref. 2; AAL95705/AAL95706).	signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						ATGAGTTGTTCTCCGGCTCCC	0.433													4	65					0	0	0.000602	0	0
SPATA7	55812	broad.mit.edu	37	14	88904668	88904668	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:88904668C>T	uc001xwq.2	+	12	1853	c.1702C>T	c.(1702-1704)CAG>TAG	p.Q568*	SPATA7_uc001xwr.2_Nonsense_Mutation_p.Q536*|SPATA7_uc001xws.2_Nonsense_Mutation_p.Q504*|SPATA7_uc001xwt.2_Nonsense_Mutation_p.Q462*|SPATA7_uc001xwu.2_Intron	NM_018418	NP_060888	Q9P0W8	SPAT7_HUMAN	spermatogenesis-associated protein 7 isoform a	568					response to stimulus|visual perception					ovary(1)	1						CCAATCTGTTCAGTTCTCCAG	0.398													7	43					0	0	0.003080	0	0
C14orf102	55051	broad.mit.edu	37	14	90754980	90754980	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:90754980G>A	uc001xyi.1	-	11	2770	c.2739C>T	c.(2737-2739)TTC>TTT	p.F913F	C14orf102_uc010atp.1_Silent_p.F418F|C14orf102_uc001xyj.1_Silent_p.F682F|C14orf102_uc001xyk.1_Silent_p.F105F	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	913							protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		TCAAATACTGGAAGAGCATGA	0.507													4	34					0	0	0.001168	0	0
CATSPERB	79820	broad.mit.edu	37	14	92055929	92055929	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:92055929G>A	uc001xzs.1	-	24	3045	c.2905C>T	c.(2905-2907)CCA>TCA	p.P969S	CATSPERB_uc010aub.1_Missense_Mutation_p.P491S	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	969					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				ACCAGATATGGAGATTGCAAT	0.363													7	49					0	0	0.008291	0	0
CATSPERB	79820	broad.mit.edu	37	14	92083984	92083984	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:92083984C>T	uc001xzs.1	-	20	2497	c.2357G>A	c.(2356-2358)AGT>AAT	p.S786N	CATSPERB_uc010aub.1_Missense_Mutation_p.S308N	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	786					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TATTACATAACTGTCAGTATC	0.313													6	33					0	0	0.001168	0	0
RIN3	79890	broad.mit.edu	37	14	93118037	93118037	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:93118037C>T	uc001yap.2	+	6	795	c.643C>T	c.(643-645)CAT>TAT	p.H215Y	RIN3_uc010auk.2_5'UTR|RIN3_uc001yaq.2_Missense_Mutation_p.H140Y|RIN3_uc001yar.1_5'UTR|RIN3_uc001yas.1_5'UTR	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	215					endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				GCCCACAGCCCATGACGCAAA	0.592													6	42					0	0	0.001168	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756700	94756700	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:94756700C>T	uc001yct.2	-	2	697	c.231G>A	c.(229-231)AAG>AAA	p.K77K	SERPINA10_uc001ycu.3_Silent_p.K77K	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	77					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TTGAAGTCTCCTTGGCAAGCT	0.557													4	33					0	0	0.000602	0	0
SERPINA11	256394	broad.mit.edu	37	14	94914781	94914781	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:94914781G>A	uc001ydd.1	-	2	391	c.331C>T	c.(331-333)CCT>TCT	p.P111S		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	111					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		TCGGCTTCAGGGGTTTCTGTG	0.587													15	89					0	0	0.003163	0	0
SERPINA3	12	broad.mit.edu	37	14	95080919	95080919	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:95080919C>T	uc001ydp.2	+	2	220	c.141C>T	c.(139-141)CTC>CTT	p.L47L	SERPINA3_uc001ydo.3_Silent_p.L72L|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Silent_p.L47L|SERPINA3_uc001yds.2_Silent_p.L47L|SERPINA3_uc010avg.2_Silent_p.L47L	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	47					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		ACGTGGACCTCGGATTAGCCT	0.567													6	73					0	0	0.001984	0	0
SERPINA3	12	broad.mit.edu	37	14	95085577	95085577	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:95085577G>A	uc001ydp.2	+	3	768	c.689G>A	c.(688-690)AGG>AAG	p.R230K	SERPINA3_uc001ydo.3_Missense_Mutation_p.R255K|SERPINA3_uc001ydr.2_Intron|SERPINA3_uc001ydq.2_Missense_Mutation_p.R230K|SERPINA3_uc001yds.2_Missense_Mutation_p.R230K|SERPINA3_uc010avg.2_Missense_Mutation_p.R230K	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	230					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		CATCAGTCAAGGTTCTACTTG	0.527													5	52					0	0	0.000602	0	0
DICER1	23405	broad.mit.edu	37	14	95590606	95590606	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:95590606G>A	uc001ydw.2	-	9	1485	c.1303C>T	c.(1303-1305)CCT>TCT	p.P435S	DICER1_uc001ydv.2_Missense_Mutation_p.P425S|DICER1_uc001ydx.2_Missense_Mutation_p.P435S	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	435	Helicase C-terminal.|Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AAAGGAGAAGGAAAATTTGTC	0.343			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				11	39					0	0	0.008291	0	0
CLMN	79789	broad.mit.edu	37	14	95669759	95669759	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:95669759G>A	uc001yef.2	-	9	2043	c.1927C>T	c.(1927-1929)CCT>TCT	p.P643S		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	643						integral to membrane	actin binding				0				Epithelial(152;0.193)		GGGGCTGAAGGACAGCCTTCA	0.473													11	70					0	0	0.010729	0	0
SETD3	84193	broad.mit.edu	37	14	99866594	99866594	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:99866594C>T	uc001ygc.2	-	12	1350	c.1180G>A	c.(1180-1182)GAA>AAA	p.E394K		NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	394					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				TCTTTCAGTTCTTCTACAAGA	0.388													5	48					0	0	0.000602	0	0
CYP46A1	10858	broad.mit.edu	37	14	100182517	100182517	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:100182517C>T	uc001ygo.2	+	9	888	c.888C>T	c.(886-888)TTC>TTT	p.F296F	CYP46A1_uc001ygp.2_Silent_p.F143F	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	296					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				TGGACAACTTCGTCACCTTCT	0.542													5	54					0	0	0.000602	0	0
DLK1	8788	broad.mit.edu	37	14	101200880	101200880	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:101200880C>T	uc001yhs.3	+	5	952	c.799C>T	c.(799-801)CGC>TGC	p.R267C	DLK1_uc001yhu.3_Intron	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	267	Extracellular (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				GCTGGCCTACCGCCTGACCCC	0.637													5	33					0	0	0.000602	0	0
RTL1	388015	broad.mit.edu	37	14	101350867	101350867	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:101350867C>T	uc010txj.1	-	1	318	c.259G>A	c.(259-261)GAA>AAA	p.E87K	MIR432_hsa-mir-432|MI0003133_RNA|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	87										pancreas(1)	1						TCCTCTATTTCCTTACGTGGG	0.557													4	54					0	0	0.000602	0	0
MIR300	100126297	broad.mit.edu	37	14	101507748	101507748	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:101507748G>A	hsa-mir-300|MI0005525	+			c.49G>A			MIR1185-1_hsa-mir-1185-1|MI0003844_5'Flank|MIR1185-2_hsa-mir-1185-2|MI0003821_5'Flank																	0						TACTTGCAATGATTATACAAG	0.493													15	52					0	0	0.004007	0	0
MIR485	574436	broad.mit.edu	37	14	101521802	101521802	+	RNA	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:101521802T>G	hsa-mir-485|MI0002469	+			c.47T>G			hsa-mir-323b|MI0014206_5'Flank																	0						TCAAAGCGAGTCATACACGGC	0.532													5	61					0	0	0.000602	0	0
TECPR2	9895	broad.mit.edu	37	14	102916011	102916011	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:102916011C>T	uc001ylw.1	+	14	3269	c.3121C>T	c.(3121-3123)CAG>TAG	p.Q1041*	TECPR2_uc010awl.2_Nonsense_Mutation_p.Q1041*|TECPR2_uc010txx.1_Nonsense_Mutation_p.Q204*	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1041							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						CAGCTTATTTCAGACGATAAT	0.537													22	110					0	0	0.004656	0	0
TDRD9	122402	broad.mit.edu	37	14	104490932	104490932	+	Missense_Mutation	SNP	C	A	A	rs139118201	by1000genomes	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:104490932C>A	uc001yom.3	+	25	2663	c.2633C>A	c.(2632-2634)ACG>AAG	p.T878K	TDRD9_uc001yon.3_Missense_Mutation_p.T616K	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	878					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				CAGAAGCAGACGGTAGATCCT	0.343													12	53					2.94398e-08	3.18773e-08	0.007413	1	0
AHNAK2	113146	broad.mit.edu	37	14	105418955	105418955	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:105418955G>A	uc010axc.1	-	7	2953	c.2833C>T	c.(2833-2835)CTG>TTG	p.L945L	AHNAK2_uc001ypx.2_Silent_p.L845L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	945						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGCCTTTCAGGTCCAGCTTG	0.607													37	159					0	0	0.008740	0	0
ADAM6	8755	broad.mit.edu	37	14	106091302	106091303	+	RNA	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:106091302_106091303CC>TT	uc010tyt.1	-	3647		c.62205_62206GG>AA			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron					Parts of antibodies, mostly variable regions.												0						CACTTGTACTCCTTGCCGTTCA	0.589													17	326					0	0	0.004672	0	0
ADAM6	8755	broad.mit.edu	37	14	106236253	106236253	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:106236253G>A	uc010tyt.1	-	3616		c.57691C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Intron|uc001ysf.2_Intron|uc001ysh.1_RNA|uc001ysi.1_RNA					Parts of antibodies, mostly variable regions.												0						CAGGGGTCCGGGAAATCATAA	0.582													25	47					0	0	0.003330	0	0
ADAM6	8755	broad.mit.edu	37	14	106405666	106405666	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:106405666G>A	uc010tyt.1	-	2358		c.42398C>T								Parts of antibodies, mostly variable regions.												0						CAGCTGCAGGGAGAACTGGTT	0.493													12	64					0	0	0.001855	0	0
ADAM6	8755	broad.mit.edu	37	14	106539233	106539233	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:106539233C>T	uc010tyt.1	-	1519		c.31460G>A								Parts of antibodies, mostly variable regions.												0						CCATCCCATCCACTCAAGCCC	0.537													21	94					0	0	0.012319	0	0
ADAM6	8755	broad.mit.edu	37	14	106725454	106725454	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:106725454G>A	uc010tyt.1	-	588		c.18093C>T								Parts of antibodies, mostly variable regions.												0						GGACCCCCCAGGCTGTACCAA	0.587													9	96					0	0	0.006214	0	0
ADAM6	8755	broad.mit.edu	37	14	106829751	106829751	+	RNA	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:106829751A>C	uc010tyt.1	-	323		c.12754T>G			uc001ysx.1_RNA					Parts of antibodies, mostly variable regions.												0						AATCCACTCCAGCCCCTTCCC	0.552													6	68					0	0	0.001984	0	0
ADAM6	8755	broad.mit.edu	37	14	106845496	106845496	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:106845496G>A	uc010tyt.1	-	305		c.12218C>T								Parts of antibodies, mostly variable regions.												0						CCCTTTCCTGGAGCCTGATGG	0.552													23	108					0	0	0.003954	0	0
ADAM6	8755	broad.mit.edu	37	14	106866491	106866491	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:106866491G>A	uc010tyt.1	-	281		c.11740C>T								Parts of antibodies, mostly variable regions.												0						ATTGTCTCTGGAGATGGTGAA	0.527													7	95					0	0	0.003080	0	0
ADAM6	8755	broad.mit.edu	37	14	106866503	106866503	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:106866503C>T	uc010tyt.1	-	281		c.11728G>A								Parts of antibodies, mostly variable regions.												0						GATGGTGAATCTGCCCTTCCT	0.517													7	89					0	0	0.001984	0	0
ADAM6	8755	broad.mit.edu	37	14	107078658	107078658	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:107078658C>T	uc010tyt.1	-	117		c.5632G>A								Parts of antibodies, mostly variable regions.												0						ACTGCACCAGCTGCATTTGGG	0.557													10	29					0	0	0.010729	0	0
ADAM6	8755	broad.mit.edu	37	14	107083350	107083350	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:107083350C>T	uc010tyt.1	-	113		c.5443G>A								Parts of antibodies, mostly variable regions.												0						TATGGTGACTCGACTCTTGAG	0.552													7	75					0	0	0.006214	0	0
ADAM6	8755	broad.mit.edu	37	14	107178989	107178989	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:107178989C>T	uc010tyt.1	-	32		c.2249G>A								Parts of antibodies, mostly variable regions.												0						CAGGGCCTTCCCTGGGGGCTG	0.532													6	65					0	0	0.001984	0	0
ADAM6	8755	broad.mit.edu	37	14	107210977	107210977	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr14:107210977C>T	uc010tyt.1	-	18		c.1364G>A								Parts of antibodies, mostly variable regions.												0						TCAGGCTGTTCATTTGCAGAT	0.532													6	53					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	15	20193130	20193130	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:20193130G>A	uc010tyv.1	-	2		c.140C>T								Homo sapiens immunoglobulin heavy chain leader and variable region mRNA, partial cds.																		CACTGAAGGTGAATCCAGAGG	0.537													6	14					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	15	20643903	20643903	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:20643903G>A	uc001ytg.2	-	23	3576	c.2867C>T	c.(2866-2868)ACC>ATC	p.T956I	uc010tyx.1_RNA|uc001yth.3_Missense_Mutation_p.T956I					RecName: Full=Putative HERC2-like protein 3;																		GAACTGCACGGTGATTTTGCC	0.512													14	100					0	0	0.004007	0	0
Unknown	0	broad.mit.edu	37	15	20649574	20649574	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:20649574C>T	uc001ytg.2	-	18	2644	c.1935G>A	c.(1933-1935)AGG>AGA	p.R645R	uc010tyx.1_RNA|uc001yth.3_Silent_p.R645R|uc010tyy.1_Silent_p.R645R					RecName: Full=Putative HERC2-like protein 3;																		CTTTCCCCATCCTGTAGGAGT	0.592													10	173					0	0	0.008291	0	0
Unknown	0	broad.mit.edu	37	15	20649655	20649655	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:20649655G>A	uc001ytg.2	-	18	2563	c.1854C>T	c.(1852-1854)GGC>GGT	p.G618G	uc010tyx.1_RNA|uc001yth.3_Silent_p.G618G|uc010tyy.1_Silent_p.G618G					RecName: Full=Putative HERC2-like protein 3;																		CTCGGCCTAGGCCTGGAGGAG	0.557													11	102					0	0	0.001855	0	0
MKRN3	7681	broad.mit.edu	37	15	23811410	23811410	+	Missense_Mutation	SNP	C	T	T	rs146108146		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:23811410C>T	uc001ywh.3	+	1	957	c.481C>T	c.(481-483)CCG>TCG	p.P161S	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.P161S	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	161						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GGAAGCCCCCCCGGCTGCATC	0.647													5	28					0	0	0.001984	0	0
NDN	4692	broad.mit.edu	37	15	23931706	23931706	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:23931706C>G	uc001ywk.2	-	1	745	c.659G>C	c.(658-660)CGG>CCG	p.R220P		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	220	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CTTCCAGGGCCGCAGCCCCAG	0.607									Prader-Willi_syndrome				15	20					0	0	0.004990	0	0
C15orf2	23742	broad.mit.edu	37	15	24921298	24921298	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:24921298G>A	uc001ywo.2	+	1	758	c.284G>A	c.(283-285)AGG>AAG	p.R95K		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	95					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CTGGCCATCAGGAAGACACCC	0.672													5	30					0	0	0.000602	0	0
C15orf2	23742	broad.mit.edu	37	15	24921643	24921643	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:24921643G>A	uc001ywo.2	+	1	1103	c.629G>A	c.(628-630)GGA>GAA	p.G210E		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	210					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTCTGGAGGGAAATGTCTAC	0.612													4	18					0	0	0.009096	0	0
SNURF	8926	broad.mit.edu	37	15	25213133	25213133	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:25213133C>T	uc001ywu.2	+	3	291	c.165C>T	c.(163-165)TTC>TTT	p.F55F	SNRPN_uc001ywp.1_5'UTR|SNRPN_uc001ywq.1_5'UTR|SNRPN_uc001ywr.1_5'UTR|SNRPN_uc001yws.1_Intron|SNRPN_uc001ywt.1_5'UTR|SNRPN_uc001ywv.1_5'UTR|SNRPN_uc001yww.1_5'UTR|SNRPN_uc001ywx.1_5'UTR|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_RNA|SNRPN_uc001ywy.1_Silent_p.F55F	NM_022804	NP_073715	Q9Y675	SNURF_HUMAN	SNRPN upstream reading frame protein	55						nucleus					0		all_cancers(20;1.4e-21)|Breast(32;0.000625)		all cancers(64;3.48e-07)|Epithelial(43;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0142)		TGGTGGATTTCCAGGCTGAAC	0.438													5	89					0	0	0.001984	0	0
GABRB3	2562	broad.mit.edu	37	15	26825523	26825523	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:26825523G>A	uc001zaz.2	-	6	767	c.625C>T	c.(625-627)CCG>TCG	p.P209S	GABRB3_uc010uae.1_Missense_Mutation_p.P124S|GABRB3_uc001zba.2_Missense_Mutation_p.P209S|GABRB3_uc001zbb.2_Missense_Mutation_p.P265S	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	209	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GAGAACTGCGGGAGCTCAATC	0.562													10	61					0	0	0.006214	0	0
RYR3	6263	broad.mit.edu	37	15	33858947	33858947	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:33858947C>T	uc001zhi.2	+	12	1285	c.1215C>T	c.(1213-1215)TCC>TCT	p.S405S	RYR3_uc010bar.2_Silent_p.S405S	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	405	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTGAGGAGTCCCAGGCTGCTC	0.532													5	87					0	0	0.001168	0	0
C15orf24	56851	broad.mit.edu	37	15	34382602	34382602	+	Silent	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:34382602A>C	uc001zhm.2	-	3	424	c.411T>G	c.(409-411)CCT>CCG	p.P137P	C15orf24_uc001zhn.2_Silent_p.P20P	NM_020154	NP_064539	Q9NPA0	CO024_HUMAN	chromosome 15 open reading frame 24 precursor	137	Extracellular (Potential).					cytoplasm|integral to membrane	carbohydrate binding|carboxypeptidase activity|purine nucleotide binding				0		all_lung(180;1.76e-08)		all cancers(64;2.02e-17)|GBM - Glioblastoma multiforme(113;2.15e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)		TCATTTGGAGAGGATAGGGCA	0.393													3	44					0	0	0.004672	0	0
C15orf55	256646	broad.mit.edu	37	15	34640322	34640322	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:34640322C>T	uc001zif.2	+	2	324	c.169C>T	c.(169-171)CCA>TCA	p.P57S	C15orf55_uc010ucc.1_Missense_Mutation_p.P85S|C15orf55_uc010ucd.1_Missense_Mutation_p.P75S	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	57	Pro-rich.					cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		AGTATTCTCTCCAGACAACCC	0.597			T	BRD3|BRD4	lethal midline carcinoma								20	74					0	0	0.002780	0	0
C15orf55	256646	broad.mit.edu	37	15	34647863	34647863	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:34647863G>A	uc001zif.2	+	7	1725	c.1570G>A	c.(1570-1572)GGA>AGA	p.G524R	C15orf55_uc010ucc.1_Missense_Mutation_p.G552R|C15orf55_uc010ucd.1_Missense_Mutation_p.G542R	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	524						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CGCTTGCCTTGGAAAGGTTTC	0.587			T	BRD3|BRD4	lethal midline carcinoma								8	81					0	0	0.003080	0	0
C15orf55	256646	broad.mit.edu	37	15	34648432	34648432	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:34648432G>A	uc001zif.2	+	7	2294	c.2139G>A	c.(2137-2139)AGG>AGA	p.R713R	C15orf55_uc010ucc.1_Silent_p.R741R|C15orf55_uc010ucd.1_Silent_p.R731R	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	713						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CTGGGGAGAGGGACGATGTCT	0.552			T	BRD3|BRD4	lethal midline carcinoma								7	48					0	0	0.004482	0	0
ATPBD4	89978	broad.mit.edu	37	15	35703089	35703089	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:35703089G>A	uc001zja.2	-	6	576	c.514C>T	c.(514-516)CCT>TCT	p.P172S	ATPBD4_uc001ziz.2_Missense_Mutation_p.P156S	NM_080650	NP_542381	Q7L8W6	ATBD4_HUMAN	ATP binding domain 4 isoform 1	172											0		all_epithelial(112;2.11e-09)|Lung NSC(122;2.38e-08)|all_lung(180;3.65e-07)		all cancers(64;9.9e-19)|GBM - Glioblastoma multiforme(113;2.01e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)		TGCTTATCAGGATCTAAACCT	0.383													14	160					0	0	0.007413	0	0
CSNK1A1P	161635	broad.mit.edu	37	15	37110216	37110216	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:37110216C>T	uc001zjg.3	-	1		c.492G>A				NR_027320				Homo sapiens casein kinase 1, alpha 1 pseudogene, mRNA (cDNA clone IMAGE:5166482).												0						ACTACCACTTCTTCACCGTTG	0.502													7	30					0	0	0.001984	0	0
FAM98B	283742	broad.mit.edu	37	15	38757492	38757492	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:38757492C>T	uc001zkb.1	+	3	275	c.240C>T	c.(238-240)TTC>TTT	p.F80F	FAM98B_uc001zkc.2_Silent_p.F80F	NM_001042429	NP_001035894	Q52LJ0	FA98B_HUMAN	family with sequence similarity 98, member B	80						tRNA-splicing ligase complex	protein binding			ovary(1)	1		all_cancers(109;3.11e-17)|all_epithelial(112;2.64e-15)|Lung NSC(122;2.11e-11)|all_lung(180;5.61e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;9e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0209)		TAGAGAGCTTCCAGCTTGAGA	0.303													5	41					0	0	0.000602	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40282489	40282489	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:40282489G>A	uc001zkm.1	+	16	2592	c.2542G>A	c.(2542-2544)GAT>AAT	p.D848N	EIF2AK4_uc010bbj.1_Missense_Mutation_p.D549N|EIF2AK4_uc001zkn.1_5'Flank	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	848	Protein kinase 2.	Proton acceptor (By similarity).			translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GATTCACCGGGATTTGAAGCC	0.378													8	138					0	0	0.006214	0	0
INO80	54617	broad.mit.edu	37	15	41275114	41275114	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:41275114C>T	uc001zni.2	-	35	4612	c.4399G>A	c.(4399-4401)GCT>ACT	p.A1467T	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1467	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						GCCGCTGCAGCCCCGGCTTTG	0.607													5	85					0	0	0.000602	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42282377	42282377	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:42282377G>A	uc001zow.1	-	13	1440	c.1440C>T	c.(1438-1440)CCC>CCT	p.P480P	PLA2G4E_uc010udc.1_5'UTR|PLA2G4E_uc001zov.1_Silent_p.P133P	NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	497	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		AGATGGGCAGGGGGTTCTGGC	0.517													31	146					0	0	0.013726	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42298262	42298262	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:42298262G>A	uc001zow.1	-	3	364	c.364C>T	c.(364-366)CTG>TTG	p.L122L		NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	133	C2.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		AGAACTGTCAGGAGATGGTCA	0.522													6	54					0	0	0.001168	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42375969	42375969	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:42375969C>T	uc001zox.2	-	7	575	c.480G>A	c.(478-480)GAG>GAA	p.E160E		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	160					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		GGCATGACAGCTCTCGGGCCT	0.602													11	54					0	0	0.013537	0	0
ZFP106	64397	broad.mit.edu	37	15	42743035	42743035	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:42743035G>A	uc001zpw.2	-	2	1701	c.1366C>T	c.(1366-1368)CCA>TCA	p.P456S	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Missense_Mutation_p.P239S|ZFP106_uc001zpy.1_Missense_Mutation_p.P479S	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	456						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		GCTGGACATGGAAGGAGTGGG	0.423													15	148					0	0	0.004007	0	0
CDAN1	146059	broad.mit.edu	37	15	43019896	43019897	+	Missense_Mutation	DNP	GG	AA	AA	rs142276684		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:43019896_43019897GG>AA	uc001zql.2	-	23	3135_3136	c.3018_3019CC>TT	c.(3016-3021)GCCCGG>GCTTGG	p.R1007W	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Missense_Mutation_p.R333W	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	1007						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CGCTCCCCCCGGGCAGCAGGTT	0.624													6	23					0	0	0.004672	0	0
MAP1A	4130	broad.mit.edu	37	15	43820735	43820735	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:43820735A>C	uc001zrt.2	+	4	7531	c.7064A>C	c.(7063-7065)GAG>GCG	p.E2355A		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2355						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GTTCCCTCTGAGGATTGTGCA	0.632													5	32					0	0	0.001168	0	0
MAP1A	4130	broad.mit.edu	37	15	43821450	43821450	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:43821450G>A	uc001zrt.2	+	4	8246	c.7779G>A	c.(7777-7779)GAG>GAA	p.E2593E		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2593						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGAGAGTAGAGAGGCTACGGG	0.667													5	35					0	0	0.000602	0	0
CATSPER2P1	440278	broad.mit.edu	37	15	44028388	44028388	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:44028388G>A	uc001zss.2	-	4		c.1393C>T				NR_002318				Homo sapiens cation channel, sperm associated 2 pseudogene 1, mRNA (cDNA clone IMAGE:5294645).												0						ATAATAACTCGAATTTGACGG	0.488													43	179					0	0	0.014410	0	0
MFAP1	4236	broad.mit.edu	37	15	44105298	44105298	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:44105298G>A	uc001zth.1	-	6	958	c.774C>T	c.(772-774)TCC>TCT	p.S258S		NM_005926	NP_005917	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	258						microfibril				skin(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		ATGCAGCCAGGGATCGCTTGT	0.443													29	155					0	0	0.006320	0	0
SPG11	80208	broad.mit.edu	37	15	44867233	44867233	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:44867233C>T	uc001ztx.2	-	31	5904	c.5873G>A	c.(5872-5874)AGT>AAT	p.S1958N	SPG11_uc010bdw.2_Intron|SPG11_uc010ueh.1_Intron|SPG11_uc010uei.1_Missense_Mutation_p.S1958N|SPG11_uc001zty.1_Missense_Mutation_p.S687N	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1958	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		ACTATCCAGACTTGAAGCTGG	0.498													8	44					0	0	0.010729	0	0
TRIM69	140691	broad.mit.edu	37	15	45059798	45059798	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:45059798G>A	uc001zuf.2	+	8	2226	c.1331G>A	c.(1330-1332)GGC>GAC	p.G444D	TRIM69_uc001zui.1_Missense_Mutation_p.G240D|TRIM69_uc010bdy.1_Missense_Mutation_p.G223D|TRIM69_uc001zug.1_Missense_Mutation_p.G444D|TRIM69_uc001zuh.1_Missense_Mutation_p.G285D	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	444	B30.2/SPRY.				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		GACAAGGTGGGCATATACCTG	0.408													7	47					0	0	0.003080	0	0
DUOX1	53905	broad.mit.edu	37	15	45431636	45431636	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:45431636G>A	uc001zus.1	+	13	1574	c.1228G>A	c.(1228-1230)GGG>AGG	p.G410R	DUOX1_uc001zut.1_Missense_Mutation_p.G410R|DUOX1_uc010bee.1_Intron	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	410	Peroxidase-like; mediates peroxidase activity.|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TTTCTGGCCTGGGCCACTGAA	0.642													17	92					0	0	0.004990	0	0
SPATA5L1	79029	broad.mit.edu	37	15	45702582	45702582	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:45702582C>G	uc001zve.2	+	3	1397	c.1288C>G	c.(1288-1290)CCT>GCT	p.P430A	SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	430						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		CCAGGACAATCCTGTGATTGA	0.333													6	41					0	0	0.001168	0	0
SLC12A1	6557	broad.mit.edu	37	15	48500135	48500135	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:48500135C>T	uc001zwn.3	+	2	435	c.219C>T	c.(217-219)TTC>TTT	p.F73F	SLC12A1_uc010uew.1_Intron|SLC12A1_uc010bem.2_Silent_p.F73F|SLC12A1_uc010uex.1_Silent_p.F73F	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	73	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	ATGACAATTTCCTCCAAAGTG	0.428													10	47					0	0	0.010729	0	0
C15orf33	196951	broad.mit.edu	37	15	49867222	49867222	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:49867222G>A	uc001zxl.2	-	8	925	c.631C>T	c.(631-633)CTC>TTC	p.L211F	C15orf33_uc001zxm.2_Missense_Mutation_p.L211F	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	211										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		AATTTATGGAGAAACCACCAC	0.289													10	49					0	0	0.008291	0	0
ATP8B4	79895	broad.mit.edu	37	15	50366334	50366334	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:50366334A>C	uc001zxu.2	-	3	219	c.77T>G	c.(76-78)TTC>TGC	p.F26C	ATP8B4_uc010ber.2_5'UTR|ATP8B4_uc010ufd.1_5'UTR|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	26	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CGCATACTGGAACTTTTCATT	0.378													5	52					0	0	0.001168	0	0
HDC	3067	broad.mit.edu	37	15	50534753	50534753	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:50534753G>A	uc001zxz.2	-	12	1799	c.1693C>T	c.(1693-1695)CTG>TTG	p.L565L	HDC_uc001zxy.2_Silent_p.L308L|HDC_uc010uff.1_Silent_p.L532L	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	565					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	AAGGAGGACAGCTTGTGCTTG	0.527													6	107					0	0	0.001168	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350300	51350300	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:51350300C>T	uc001zyy.2	-	3	757	c.657G>A	c.(655-657)AGG>AGA	p.R219R		NM_207381	NP_997264	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein	219											0				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		AGAGCACGTTCCTATCGAAGG	0.557													9	30					0	0	0.004482	0	0
CYP19A1	1588	broad.mit.edu	37	15	51503147	51503147	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:51503147C>T	uc001zyz.3	-	11	1621	c.1370G>A	c.(1369-1371)CGA>CAA	p.R457Q	CYP19A1_uc001zza.3_Missense_Mutation_p.R457Q	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	457					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	CACGTGGAATCGTCTCAGAAG	0.473													9	46					0	0	0.010729	0	0
DMXL2	23312	broad.mit.edu	37	15	51830440	51830440	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:51830440C>A	uc002abf.2	-	10	1540	c.1315G>T	c.(1315-1317)GAA>TAA	p.E439*	DMXL2_uc010ufy.1_Nonsense_Mutation_p.E439*|DMXL2_uc010bfa.2_Nonsense_Mutation_p.E439*	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	439						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		AAACCCCGTTCTCTATCCTCC	0.353													6	65					8.12818e-05	8.76148e-05	0.001984	1	0
LYSMD2	256586	broad.mit.edu	37	15	52017164	52017164	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:52017164A>C	uc002abi.2	-	2	929	c.428T>G	c.(427-429)TTT>TGT	p.F143C	LYSMD2_uc002abj.2_Missense_Mutation_p.F52C	NM_153374	NP_699205	Q8IV50	LYSM2_HUMAN	LysM, putative peptidoglycan-binding, domain	143					cell wall macromolecule catabolic process						0				all cancers(107;0.00258)		TTCCTGAGAAAAACTGTTATC	0.463													10	112					0	0	0.006214	0	0
LEO1	123169	broad.mit.edu	37	15	52245340	52245340	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:52245340C>T	uc002abo.2	-	8	1477	c.1461G>A	c.(1459-1461)ACG>ACA	p.T487T	LEO1_uc010bfd.2_Silent_p.T427T	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	487					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		AGGTGAGTTTCGTTTTAAAGA	0.378													4	23					0	0	0.000602	0	0
GNB5	10681	broad.mit.edu	37	15	52418213	52418213	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:52418213C>T	uc002abt.1	-	11	1006	c.941G>A	c.(940-942)AGG>AAG	p.R314K	GNB5_uc002abr.1_Missense_Mutation_p.R272K|GNB5_uc002abs.1_Missense_Mutation_p.R202K	NM_016194	NP_057278	O14775	GBB5_HUMAN	guanine nucleotide-binding protein, beta-5	314	WD 5.					heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)	1				all cancers(107;0.0163)		GGCAACCTCCCTATCTGCCCG	0.458													5	13					0	0	0.001984	0	0
MYO5C	55930	broad.mit.edu	37	15	52487585	52487585	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:52487585G>A	uc010bff.2	-	40	5202	c.5065C>T	c.(5065-5067)CGC>TGC	p.R1689C	MYO5C_uc010uga.1_RNA|uc002abv.2_Intron	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	1689	Dilute.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		TGTACTTTGCGAACAAAGGAT	0.348													11	34					0	0	0.001855	0	0
MYO5C	55930	broad.mit.edu	37	15	52534250	52534250	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:52534250G>A	uc010bff.2	-	20	2688	c.2551C>T	c.(2551-2553)CGA>TGA	p.R851*	MYO5C_uc010uga.1_Intron|MYO5C_uc010ugb.1_Intron	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	851	IQ 4.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		CTCACCTTTCGATACCTCCTC	0.552													16	129					0	0	0.004007	0	0
WDR72	256764	broad.mit.edu	37	15	53889321	53889321	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:53889321C>T	uc002acj.2	-	18	3145	c.3103G>A	c.(3103-3105)GAA>AAA	p.E1035K		NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	1035										lung(1)|skin(1)	2				all cancers(107;0.0511)		TCTAGTTCTTCTGTCCATTCC	0.388													16	135					0	0	0.004990	0	0
UNC13C	440279	broad.mit.edu	37	15	54307588	54307588	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:54307588A>T	uc002ack.2	+	1	2488	c.2488A>T	c.(2488-2490)ATG>TTG	p.M830L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	830					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CTCTTCATTAATGGGGAGATT	0.438													11	29					0	0	0.013537	0	0
CGNL1	84952	broad.mit.edu	37	15	57730340	57730340	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:57730340G>A	uc002aeg.2	+	2	219	c.143G>A	c.(142-144)GGA>GAA	p.G48E	CGNL1_uc010bfw.2_Missense_Mutation_p.G48E	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	48	Head.|ZIM (By similarity).					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		CGGGTCCAGGGAATTGATGGT	0.498													9	84					0	0	0.004482	0	0
CGNL1	84952	broad.mit.edu	37	15	57730408	57730408	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:57730408G>A	uc002aeg.2	+	2	287	c.211G>A	c.(211-213)GAA>AAA	p.E71K	CGNL1_uc010bfw.2_Missense_Mutation_p.E71K	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	71	Head.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		ATCGTTTTCTGAAAATGGGCC	0.488													17	49					0	0	0.008871	0	0
GCOM1	145781	broad.mit.edu	37	15	57913875	57913875	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:57913875C>T	uc002aei.2	+	4	507	c.388C>T	c.(388-390)CGA>TGA	p.R130*	GCOM1_uc002aej.2_Nonsense_Mutation_p.R130*|GCOM1_uc002aek.2_Intron|GCOM1_uc002ael.2_Intron|GCOM1_uc002aem.2_Nonsense_Mutation_p.R130*|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Nonsense_Mutation_p.R130*|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	130	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						ACAGAAGATTCGACAGCTCAC	0.473													7	114					0	0	0.003080	0	0
GCOM1	145781	broad.mit.edu	37	15	57925876	57925876	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:57925876C>T	uc002aei.2	+	8	989	c.870C>T	c.(868-870)ATC>ATT	p.I290I	GCOM1_uc002aej.2_Silent_p.I290I|GCOM1_uc002aek.2_RNA|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Silent_p.I290I|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Silent_p.I290I|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	290	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						CAGCAGAGATCAGCCTAGAGG	0.478													9	64					0	0	0.006214	0	0
VPS13C	54832	broad.mit.edu	37	15	62204146	62204146	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:62204146G>A	uc002agz.2	-	63	8682	c.8608C>T	c.(8608-8610)CCC>TCC	p.P2870S	VPS13C_uc002aha.2_Missense_Mutation_p.P2827S|VPS13C_uc002ahb.1_Missense_Mutation_p.P2870S|VPS13C_uc002ahc.1_Missense_Mutation_p.P2827S|VPS13C_uc002ahd.1_Missense_Mutation_p.P247S	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2870					protein localization					ovary(2)	2						GTACAAAAGGGAGTCAGGGTA	0.378													5	38					0	0	0.000602	0	0
ZNF609	23060	broad.mit.edu	37	15	64791938	64791938	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:64791938C>T	uc002ann.2	+	1	320	c.320C>T	c.(319-321)TCC>TTC	p.S107F	ZNF609_uc010bgy.2_Missense_Mutation_p.S107F	NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	107						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCAGGGACTTCCCTGTTCACT	0.547													8	29					0	0	0.003080	0	0
ZNF609	23060	broad.mit.edu	37	15	64968435	64968436	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:64968435_64968436CC>TT	uc002ann.2	+	4	3382_3383	c.3382_3383CC>TT	c.(3382-3384)CCA>TTA	p.P1128L		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	1128						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						AGAGATGGATCCAATACTCTGG	0.505													7	59					0	0	0.004672	0	0
RBPMS2	348093	broad.mit.edu	37	15	65043767	65043767	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:65043767G>A	uc002anq.2	-	2	410	c.158C>T	c.(157-159)CCG>CTG	p.P53L		NM_194272	NP_919248	Q6ZRY4	RBPS2_HUMAN	RNA binding protein with multiple splicing 2	53	RRM.						nucleic acid binding|nucleotide binding				0						CACCTTGAACGGCCGGAAGAG	0.612													7	82					0	0	0.003080	0	0
MIR1272	100302184	broad.mit.edu	37	15	65054603	65054603	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:65054603G>A	hsa-mir-1272|MI0006408	-			c.112G>A			RBPMS2_uc002anq.2_Intron																	0						CCAGACCACAGAGCACACGAG	0.552													3	26					0	0	0.000602	0	0
CILP	8483	broad.mit.edu	37	15	65494342	65494342	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:65494342G>A	uc002aon.2	-	8	1235	c.1054C>T	c.(1054-1056)CCT>TCT	p.P352S		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	352	Ig-like C2-type.				negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TAGAGGGAAGGATCCAGCAAT	0.542													23	95					0	0	0.007291	0	0
CILP	8483	broad.mit.edu	37	15	65495726	65495726	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:65495726C>T	uc002aon.2	-	7	1183	c.1002G>A	c.(1000-1002)GGG>GGA	p.G334G		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	334	Ig-like C2-type.				negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						GCCTGGGCTTCCCTGTGGCCT	0.517													8	48					0	0	0.004482	0	0
IGDCC3	9543	broad.mit.edu	37	15	65667550	65667550	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:65667550G>A	uc002aos.2	-	2	546	c.294C>T	c.(292-294)ATC>ATT	p.I98I		NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	98	Extracellular (Potential).|Ig-like C2-type 1.									ovary(3)	3						TGAAGTGACGGATCATCAAGG	0.607													5	32					0	0	0.001168	0	0
C15orf44	81556	broad.mit.edu	37	15	65891312	65891312	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:65891312G>A	uc002apd.2	-	5	839	c.503C>T	c.(502-504)TCC>TTC	p.S168F	C15orf44_uc010uix.1_Missense_Mutation_p.S204F|C15orf44_uc010uiz.1_Missense_Mutation_p.S132F|C15orf44_uc010uja.1_Missense_Mutation_p.S119F|C15orf44_uc010ujb.1_Missense_Mutation_p.S89F|C15orf44_uc002ape.3_Missense_Mutation_p.S168F|C15orf44_uc010uiy.1_Missense_Mutation_p.S89F	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2	168	VWFA.									ovary(1)	1						GCATTCCAAGGAATCGGTGCT	0.428													11	47					0	0	0.010729	0	0
IQCH	64799	broad.mit.edu	37	15	67713790	67713790	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:67713790G>A	uc002aqo.1	+	16	2427	c.2380G>A	c.(2380-2382)GTG>ATG	p.V794M	IQCH_uc002aqq.1_Missense_Mutation_p.V451M|IQCH_uc002aqp.1_Missense_Mutation_p.V455M|uc002aqr.1_RNA	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	794										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		TCAGACCTCAGTGGATCCCCA	0.493													6	53					0	0	0.001984	0	0
UACA	55075	broad.mit.edu	37	15	70969480	70969480	+	Splice_Site	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:70969480C>T	uc002asr.2	-	12	1104	c.1000_splice	c.e12-1	p.E334_splice	UACA_uc010uke.1_Splice_Site_p.E225_splice|UACA_uc002asq.2_Splice_Site_p.E321_splice|UACA_uc010bin.1_Intron	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and							cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						CCATAACTTCCTAAATTTAAA	0.274													12	51					0	0	0.002450	0	0
LRRC49	54839	broad.mit.edu	37	15	71203926	71203926	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:71203926C>T	uc002asw.2	+	6	803	c.556C>T	c.(556-558)CAT>TAT	p.H186Y	LRRC49_uc002asu.2_Missense_Mutation_p.H176Y|LRRC49_uc002asx.2_Missense_Mutation_p.H142Y|LRRC49_uc010ukf.1_Missense_Mutation_p.H191Y|LRRC49_uc002asy.2_5'UTR|LRRC49_uc002asz.2_Missense_Mutation_p.H158Y	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	186	LRR 4.					cytoplasm|microtubule				ovary(1)	1						CTTGGATCTTCATGGAAATCA	0.308													8	89					0	0	0.004482	0	0
LRRC49	54839	broad.mit.edu	37	15	71341895	71341895	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:71341895C>T	uc002asw.2	+	16	2252	c.2005C>T	c.(2005-2007)CGC>TGC	p.R669C	LRRC49_uc002asu.2_Missense_Mutation_p.R659C|LRRC49_uc002asx.2_Missense_Mutation_p.R625C|LRRC49_uc010ukf.1_Missense_Mutation_p.R674C|LRRC49_uc002asy.2_Missense_Mutation_p.R375C|LRRC49_uc002asz.2_Missense_Mutation_p.R641C	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	669						cytoplasm|microtubule				ovary(1)	1						CATAGAAATTCGCAATAAAAA	0.368													20	102					0	0	0.010504	0	0
THSD4	79875	broad.mit.edu	37	15	71535002	71535002	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:71535002G>A	uc002atb.1	+	4	558	c.479G>A	c.(478-480)GGT>GAT	p.G160D	THSD4_uc002atd.1_5'UTR	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	160	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						AGGACCCGTGGTACCATTGGC	0.512													18	194					0	0	0.008871	0	0
MYO9A	4649	broad.mit.edu	37	15	72189838	72189838	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:72189838A>G	uc002atl.3	-	25	5479	c.5006T>C	c.(5005-5007)ATT>ACT	p.I1669T	MYO9A_uc010biq.2_Missense_Mutation_p.I1289T|MYO9A_uc002atn.1_Missense_Mutation_p.I1650T|MYO9A_uc002atk.2_Missense_Mutation_p.I393T|MYO9A_uc002atm.1_Missense_Mutation_p.I393T	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1669	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						AGTGAAGAAAATGGGCCTAGC	0.373													10	61					0	0	0.006214	0	0
MYO9A	4649	broad.mit.edu	37	15	72190946	72190946	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:72190946G>A	uc002atl.3	-	25	4371	c.3898C>T	c.(3898-3900)CCT>TCT	p.P1300S	MYO9A_uc010biq.2_Missense_Mutation_p.P920S|MYO9A_uc002atn.1_Missense_Mutation_p.P1281S|MYO9A_uc002atk.2_Missense_Mutation_p.P24S|MYO9A_uc002atm.1_Missense_Mutation_p.P24S	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1300	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TCCTCTGAAGGAGAAATACCA	0.468													5	65					0	0	0.000602	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72954753	72954753	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:72954753G>A	uc010uks.1	+	11	1049	c.1008G>A	c.(1006-1008)AAG>AAA	p.K336K		NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	336	Potential.										0						AGGAACAAAAGCAGAGACTCC	0.562													23	294					0	0	0.002780	0	0
SEMA7A	8482	broad.mit.edu	37	15	74709735	74709735	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:74709735G>A	uc002axv.2	-	6	642	c.602C>T	c.(601-603)CCT>CTT	p.P201L	SEMA7A_uc010ulk.1_Missense_Mutation_p.P36L|SEMA7A_uc010ull.1_Missense_Mutation_p.P187L	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	201	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						GCGGAACCGAGGGATCTTCCC	0.602													14	61					0	0	0.001855	0	0
CYP1A2	1544	broad.mit.edu	37	15	75047276	75047276	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:75047276G>A	uc002ayr.1	+	7	1462	c.1398G>A	c.(1396-1398)TGG>TGA	p.W466*		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	466					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	TGGCCAAGTGGGAGATCTTCC	0.587													7	52					0	0	0.003080	0	0
C15orf39	56905	broad.mit.edu	37	15	75498907	75498907	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:75498907C>T	uc002azp.3	+	2	838	c.518C>T	c.(517-519)CCC>CTC	p.P173L	C15orf39_uc002azq.3_Missense_Mutation_p.P173L|C15orf39_uc002azr.3_5'Flank	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	173											0						GCTGACCCACCCTGCTCTCTG	0.622													7	60					0	0	0.004482	0	0
C15orf39	56905	broad.mit.edu	37	15	75499420	75499420	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:75499420C>T	uc002azp.3	+	2	1351	c.1031C>T	c.(1030-1032)CCC>CTC	p.P344L	C15orf39_uc002azq.3_Missense_Mutation_p.P344L|C15orf39_uc002azr.3_5'Flank	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	344											0						GACGCTTACCCCTACCCCTCT	0.667													6	69					0	0	0.001984	0	0
CHRNA5	1138	broad.mit.edu	37	15	78882342	78882342	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:78882342G>A	uc002bdy.2	+	5	771	c.609G>A	c.(607-609)GAG>GAA	p.E203E	CHRNA5_uc002bdz.2_Intron	NM_000745	NP_000736	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5	203	Extracellular (Potential).				behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TAATTCTAGAGGACCAAGATG	0.408													6	68					0	0	0.001984	0	0
C15orf26	161502	broad.mit.edu	37	15	81428989	81428989	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:81428989G>A	uc002bgb.2	+	3	319	c.292G>A	c.(292-294)GAA>AAA	p.E98K	C15orf26_uc010blp.1_Missense_Mutation_p.E73K	NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	98											0						GACTCCAGATGAAATTCAGTC	0.468													7	63					0	0	0.001984	0	0
TMC3	342125	broad.mit.edu	37	15	81625006	81625006	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:81625006G>A	uc002bgo.1	-	22	3057	c.3057C>T	c.(3055-3057)TTC>TTT	p.F1019F	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	1019	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						GTGGGTATTGGAAATTCCGGG	0.582													7	31					0	0	0.006214	0	0
TMC3	342125	broad.mit.edu	37	15	81625076	81625076	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:81625076C>T	uc002bgo.1	-	22	2987	c.2987G>A	c.(2986-2988)TGG>TAG	p.W996*	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	996	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						ATCTTCATTCCACGACTTGTA	0.557													3	8					0	0	0.004672	0	0
TMC3	342125	broad.mit.edu	37	15	81644161	81644161	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:81644161C>T	uc002bgo.1	-	10	957	c.957G>A	c.(955-957)AGG>AGA	p.R319R	TMC3_uc010blr.1_RNA|TMC3_uc002bgp.2_Silent_p.R319R	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	319	Extracellular (Potential).					integral to membrane				ovary(1)|liver(1)	2						TGGCAATAATCCTCAGGCAGA	0.537													4	8					0	0	0.009096	0	0
FAM154B	283726	broad.mit.edu	37	15	82575038	82575038	+	Missense_Mutation	SNP	C	T	T	rs149603065		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:82575038C>T	uc002bgv.2	+	3	901	c.832C>T	c.(832-834)CCT>TCT	p.P278S	FAM154B_uc010unr.1_Missense_Mutation_p.P263S|FAM154B_uc010uns.1_RNA	NM_001008226	NP_001008227	Q658L1	F154B_HUMAN	hypothetical protein LOC283726	278								p.P278S(1)		skin(2)	2						TAACAATTTTCCTTTCCAAGG	0.418													11	52					0	0	0.010729	0	0
GOLGA6L5	374650	broad.mit.edu	37	15	85053142	85053142	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:85053142C>T	uc002bkm.2	-	9		c.1905G>A			uc002bkl.1_5'Flank	NR_003246				Homo sapiens cDNA FLJ33459 fis, clone BRAMY2000585.												0						TTTTTCAATTCCTTGACCCGC	0.393													3	9					0	0	0.001168	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85164849	85164849	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:85164849G>A	uc002bkr.2	+	3	1649	c.1423G>A	c.(1423-1425)GAG>AAG	p.E475K	ZSCAN2_uc010bmz.1_Missense_Mutation_p.E473K|ZSCAN2_uc010bna.2_Missense_Mutation_p.E325K|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	475	C2H2-type 10.				cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		GAAACCCTACGAGTGCCTGAC	0.572													4	23					0	0	0.000602	0	0
SLC28A1	9154	broad.mit.edu	37	15	85478748	85478748	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:85478748C>T	uc002blg.2	+	15	1782	c.1580C>T	c.(1579-1581)TCC>TTC	p.S527F	SLC28A1_uc010bnb.2_Missense_Mutation_p.S527F|SLC28A1_uc010upe.1_Intron|SLC28A1_uc010upf.1_Missense_Mutation_p.S527F|SLC28A1_uc010upg.1_Missense_Mutation_p.S527F	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	527					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGTGGATCTCCGTGAGTGTC	0.642													8	89					0	0	0.004482	0	0
AKAP13	11214	broad.mit.edu	37	15	86076872	86076872	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:86076872C>T	uc002blv.1	+	4	409	c.239C>T	c.(238-240)CCC>CTC	p.P80L	AKAP13_uc002bls.2_Missense_Mutation_p.P80L|AKAP13_uc002blt.1_Missense_Mutation_p.P80L|AKAP13_uc002blu.1_Missense_Mutation_p.P80L	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	80					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GAGGGCCTTCCCGTGTTTGTG	0.468													10	72					0	0	0.008291	0	0
AKAP13	11214	broad.mit.edu	37	15	86259039	86259039	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:86259039C>T	uc002blv.1	+	20	5790	c.5620C>T	c.(5620-5622)CCT>TCT	p.P1874S	AKAP13_uc002blu.1_Missense_Mutation_p.P1878S|AKAP13_uc010bnf.1_Missense_Mutation_p.P495S|AKAP13_uc002blw.1_Missense_Mutation_p.P341S|AKAP13_uc002blx.1_Missense_Mutation_p.P119S	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1874					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						CAAGGAGCGTCCTCGGTCCGC	0.532													9	40					0	0	0.006214	0	0
AGBL1	123624	broad.mit.edu	37	15	86822964	86822964	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:86822964G>A	uc002blz.1	+	15	2112	c.2032G>A	c.(2032-2034)GAT>AAT	p.D678N	AGBL1_uc002bma.1_Missense_Mutation_p.D409N|AGBL1_uc002bmb.1_Missense_Mutation_p.D372N	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	678					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ACACAGTGAGGATGTCTGCTA	0.502													16	180					0	0	0.006122	0	0
AGBL1	123624	broad.mit.edu	37	15	86940638	86940638	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:86940638G>A	uc002blz.1	+	17	2358	c.2278G>A	c.(2278-2280)GGA>AGA	p.G760R		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	760					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						AGTTCATCCAGGAGAGAGCAA	0.433													4	30					0	0	0.009096	0	0
DET1	55070	broad.mit.edu	37	15	89074761	89074761	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:89074761G>A	uc002bmr.2	-	2	328	c.176C>T	c.(175-177)CCT>CTT	p.P59L	DET1_uc002bmp.3_Intron|DET1_uc010bnk.2_Intron|DET1_uc002bmq.2_Missense_Mutation_p.P70L	NM_001144074	NP_001137546	Q7L5Y6	DET1_HUMAN	de-etiolated 1 isoform 2	59						nucleus				lung(1)|pancreas(1)	2	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			CAAGAAACAAGGAGGCTTTTC	0.478													20	100					0	0	0.010504	0	0
ABHD2	11057	broad.mit.edu	37	15	89738513	89738513	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:89738513C>T	uc002bnj.2	+	16	2054	c.1137C>T	c.(1135-1137)TTC>TTT	p.F379F	ABHD2_uc002bnk.2_Silent_p.F379F	NM_007011	NP_008942	P08910	ABHD2_HUMAN	alpha/beta hydrolase domain containing protein	379						integral to membrane	carboxylesterase activity			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					ACTTGGGCTTCTTTGAGGGCT	0.547													4	40					0	0	0.009096	0	0
ANPEP	290	broad.mit.edu	37	15	90335696	90335696	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:90335696G>A	uc002bop.3	-	17	2639	c.2347C>T	c.(2347-2349)CCC>TCC	p.P783S		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	783	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TTATTATTGGGGTTCTCCATC	0.592													4	33					0	0	0.009096	0	0
ANPEP	290	broad.mit.edu	37	15	90342782	90342782	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:90342782C>T	uc002bop.3	-	13	2120	c.1828G>A	c.(1828-1830)GAT>AAT	p.D610N		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	610	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CTGAAGAGATCGTTCTGGGCT	0.592													5	61					0	0	0.001168	0	0
IQGAP1	8826	broad.mit.edu	37	15	91037962	91037962	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:91037962G>A	uc002bpl.1	+	36	4747	c.4646G>A	c.(4645-4647)AGG>AAG	p.R1549K	IQGAP1_uc010uqg.1_Missense_Mutation_p.R170K	NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1549	C2.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AAAAAGCCTAGGGAAATGAAA	0.363													7	88					0	0	0.003080	0	0
BLM	641	broad.mit.edu	37	15	91308554	91308554	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:91308554C>T	uc002bpr.2	+	9	2200	c.2103C>T	c.(2101-2103)CTC>CTT	p.L701L	BLM_uc010uqh.1_Silent_p.L701L|BLM_uc010uqi.1_Silent_p.L326L|BLM_uc010bnx.2_Silent_p.L701L|BLM_uc002bps.1_Silent_p.L263L	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	701	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			GTTACCAGCTCCCTGCCTGTG	0.403			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				30	395					0	0	0.010818	0	0
FURIN	5045	broad.mit.edu	37	15	91419063	91419063	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:91419063C>T	uc002bpu.1	+	2	309	c.93C>T	c.(91-93)ACC>ACT	p.T31T		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	31					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AGGTCTTCACCAACACGTGGG	0.627													20	139					0	0	0.012319	0	0
SV2B	9899	broad.mit.edu	37	15	91769537	91769537	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:91769537C>T	uc002bqv.2	+	1	435	c.44C>T	c.(43-45)CCC>CTC	p.P15L	SV2B_uc002bqt.2_Missense_Mutation_p.P15L|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	15	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GGCTATGCTCCCAGTGATGGC	0.517													36	265					0	0	0.005524	0	0
SV2B	9899	broad.mit.edu	37	15	91795653	91795653	+	Silent	SNP	G	A	A	rs140898181		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:91795653G>A	uc002bqv.2	+	3	1078	c.687G>A	c.(685-687)CGG>CGA	p.R229R	SV2B_uc002bqt.2_Silent_p.R229R|SV2B_uc010uqv.1_Silent_p.R78R|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	229	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity	p.R229R(1)		ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TCTTGTCTCGGGAGAAGCGAG	0.488													40	394					0	0	0.014410	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92669355	92669355	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:92669355C>T	uc002bqx.2	+	6	1440	c.1239C>T	c.(1237-1239)CTC>CTT	p.L413L	SLCO3A1_uc002bqy.2_Silent_p.L413L|SLCO3A1_uc010boc.1_RNA|SLCO3A1_uc002bqz.1_Silent_p.L355L	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	413	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			TGAAGAAGCTCAGCCTGTCTG	0.587													9	62					0	0	0.004482	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92694235	92694235	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:92694235C>T	uc002bqx.2	+	9	1945	c.1744C>T	c.(1744-1746)CGT>TGT	p.R582C	SLCO3A1_uc002bqy.2_Missense_Mutation_p.R582C|SLCO3A1_uc010boc.1_RNA|SLCO3A1_uc002bqz.1_Missense_Mutation_p.R524C	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	582	Helical; Name=11; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			TCTCCTCCTTCGTTTGTTGGG	0.373													5	44					0	0	0.000602	0	0
CHD2	1106	broad.mit.edu	37	15	93482840	93482840	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:93482840C>T	uc002bsp.2	+	7	1159	c.584C>T	c.(583-585)CCG>CTG	p.P195L	CHD2_uc002bsm.1_Missense_Mutation_p.P195L|CHD2_uc002bsn.2_Missense_Mutation_p.P195L|CHD2_uc002bso.1_Missense_Mutation_p.P195L|CHD2_uc010urb.1_Missense_Mutation_p.P208L	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	195					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AAAAAGCAGCCGAAGACTCAG	0.413													14	78					0	0	0.004007	0	0
MCTP2	55784	broad.mit.edu	37	15	94899422	94899422	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:94899422G>A	uc002btj.2	+	8	1127	c.1062G>A	c.(1060-1062)TGG>TGA	p.W354*	MCTP2_uc010urg.1_Nonsense_Mutation_p.W354*|MCTP2_uc002bti.2_Nonsense_Mutation_p.W354*|MCTP2_uc010boj.2_Nonsense_Mutation_p.W83*|MCTP2_uc010bok.2_Nonsense_Mutation_p.W354*|MCTP2_uc002btk.3_5'UTR|MCTP2_uc002btl.2_5'UTR	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	354	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			ACCAACTCTGGAACGGGATTA	0.393													11	90					0	0	0.013537	0	0
ARRDC4	91947	broad.mit.edu	37	15	98514404	98514404	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:98514404C>T	uc010bom.2	+	8	1403	c.1244C>T	c.(1243-1245)TCC>TTC	p.S415F	ARRDC4_uc002bui.3_Missense_Mutation_p.S328F	NM_183376	NP_899232	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	415					signal transduction						0	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			CAGCCTGTTTCCTTCATTCTC	0.398													7	104					0	0	0.008291	0	0
IGF1R	3480	broad.mit.edu	37	15	99442803	99442803	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:99442803C>T	uc002bul.2	+	5	1250	c.1200C>T	c.(1198-1200)TCC>TCT	p.S400S	IGF1R_uc010urq.1_Silent_p.S400S|IGF1R_uc010bon.2_Silent_p.S400S	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	400					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TCTCCTTGTCCTTCCTAAAAA	0.488													5	81					0	0	0.001984	0	0
CHSY1	22856	broad.mit.edu	37	15	101718347	101718347	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:101718347C>T	uc002bwt.1	-	4	2138	c.1655G>A	c.(1654-1656)GGA>GAA	p.G552E	CHSY1_uc010usd.1_Missense_Mutation_p.G280E	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	552	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTCAAAGTTTCCCATAAATCT	0.433													7	38					0	0	0.003080	0	0
CHSY1	22856	broad.mit.edu	37	15	101718790	101718791	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:101718790_101718791GG>AA	uc002bwt.1	-	4	1694_1695	c.1211_1212CC>TT	c.(1210-1212)GCC>GTT	p.A404V	CHSY1_uc010usd.1_Missense_Mutation_p.A132V	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	404	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTCGTCCAAGGCTTCCCTCTG	0.535													4	66					0	0	0.004672	0	0
PCSK6	5046	broad.mit.edu	37	15	101972284	101972284	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:101972284C>T	uc002bwy.2	-	4	738	c.424G>A	c.(424-426)GAA>AAA	p.E142K	PCSK6_uc010bpd.2_Missense_Mutation_p.E12K|PCSK6_uc010bpe.2_Missense_Mutation_p.E142K|PCSK6_uc002bxa.2_Missense_Mutation_p.E142K|PCSK6_uc002bxb.2_Missense_Mutation_p.E142K|PCSK6_uc002bxc.1_Missense_Mutation_p.E142K|PCSK6_uc002bxd.1_Missense_Mutation_p.E142K|PCSK6_uc002bxe.2_Missense_Mutation_p.E142K|PCSK6_uc002bxg.1_Missense_Mutation_p.E142K	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	142					glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CGTTTCACTTCCTGTTGCTGG	0.458													4	20					0	0	0.000602	0	0
OR4F6	390648	broad.mit.edu	37	15	102346165	102346165	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr15:102346165G>A	uc010utr.1	+	1	243	c.243G>A	c.(241-243)ATG>ATA	p.M81I		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CTCCCAAGATGATTTATGACC	0.478													19	149					0	0	0.007413	0	0
DECR2	26063	broad.mit.edu	37	16	461398	461398	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:461398C>T	uc002chb.2	+	8	805	c.699C>T	c.(697-699)GCC>GCT	p.A233A	DECR2_uc002chc.2_Silent_p.A149A|DECR2_uc010bqv.2_Silent_p.A149A|DECR2_uc002chd.2_Silent_p.A149A|DECR2_uc002che.1_RNA	NM_020664	NP_065715	Q9NUI1	DECR2_HUMAN	2,4-dienoyl CoA reductase 2	233						peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity|binding				0		Hepatocellular(16;0.00015)				AGGTCACTGCCAGCCCGCTGC	0.692													5	50					0	0	0.001168	0	0
PIGQ	9091	broad.mit.edu	37	16	632924	632924	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:632924C>G	uc002cho.2	+	10	1675	c.1573C>G	c.(1573-1575)CCT>GCT	p.P525A	PIGQ_uc010bqw.2_Silent_p.R545R|PIGQ_uc002chn.2_Silent_p.R545R|PIGQ_uc010uui.1_3'UTR|PIGQ_uc002chp.2_Missense_Mutation_p.P95A|uc010uuj.1_3'UTR	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	525	Leu-rich.				C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				ACACCTACCGCCTCCCCAGCT	0.652													3	100					0	0	0.009096	0	0
CACNA1H	8912	broad.mit.edu	37	16	1260921	1260921	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:1260921C>T	uc002cks.2	+	21	4421	c.4173C>T	c.(4171-4173)ATC>ATT	p.I1391I	CACNA1H_uc002ckt.2_Silent_p.I1391I|CACNA1H_uc002cku.2_Silent_p.I97I|CACNA1H_uc010brj.2_Silent_p.I97I|CACNA1H_uc002ckv.2_Silent_p.I97I	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1391	Extracellular (Potential).|III.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GCGCCAAGATCCTGGGTGTTC	0.682													8	150					0	0	0.010729	0	0
IFT140	9742	broad.mit.edu	37	16	1570249	1570249	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:1570249G>T	uc002cmb.2	-	28	4118	c.3756C>A	c.(3754-3756)AAC>AAA	p.N1252K	IFT140_uc002clz.2_Missense_Mutation_p.N865K	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	1252										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				ACTGCAGGTAGTTAGCAGCCA	0.572													32	81					2.05212e-20	2.22706e-20	0.005524	1	0
TMEM204	79652	broad.mit.edu	37	16	1604801	1604801	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:1604801G>A	uc002cmc.2	+	4	853	c.455G>A	c.(454-456)GGG>GAG	p.G152E	IFT140_uc002clz.2_Intron|IFT140_uc002cmb.2_Intron|TMEM204_uc002cmd.2_Missense_Mutation_p.G152E|TMEM204_uc010brr.1_Missense_Mutation_p.G152E|uc010brs.1_5'Flank	NM_024600	NP_078876	Q9BSN7	TM204_HUMAN	transmembrane protein 204	152	Helical; (Potential).				response to stress	adherens junction|integral to membrane					0		Hepatocellular(780;0.219)				CTGGTCATCGGGCTCGTGACT	0.582													6	76					0	0	0.001168	0	0
RPL3L	6123	broad.mit.edu	37	16	1996721	1996721	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:1996721G>A	uc002cnh.2	-	7	903	c.856C>T	c.(856-858)CGC>TGC	p.R286C		NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	286					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						CTGCCGATGCGGAAGATCTGC	0.627													6	15					0	0	0.001984	0	0
TBL3	10607	broad.mit.edu	37	16	2028358	2028358	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:2028358C>T	uc002cnu.1	+	21	2281	c.2179C>T	c.(2179-2181)CAC>TAC	p.H727Y	TBL3_uc002cnv.1_Missense_Mutation_p.H613Y|TBL3_uc010bsb.1_3'UTR|TBL3_uc010bsc.1_Missense_Mutation_p.H594Y|TBL3_uc010uvt.1_Missense_Mutation_p.H196Y|TBL3_uc002cnw.1_RNA	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	727					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0						CAACTCGCGGCACTGCCACGA	0.672													21	78					0	0	0.010504	0	0
TSC2	7249	broad.mit.edu	37	16	2130177	2130177	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:2130177C>T	uc002con.2	+	30	3515	c.3409C>T	c.(3409-3411)CTT>TTT	p.L1137F	TSC2_uc010bsd.2_Missense_Mutation_p.L1137F|TSC2_uc002coo.2_Missense_Mutation_p.L1093F|TSC2_uc010uvv.1_Missense_Mutation_p.L1057F|TSC2_uc010uvw.1_Missense_Mutation_p.L1045F|TSC2_uc002cop.2_Missense_Mutation_p.L893F|TSC2_uc002coq.2_5'Flank	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1137					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				GGGCCATGGTCTTCGAGTTGG	0.627			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				34	91					0	0	0.006230	0	0
SRRM2	23524	broad.mit.edu	37	16	2812796	2812796	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:2812796C>T	uc002crk.2	+	11	2816	c.2267C>T	c.(2266-2268)TCA>TTA	p.S756L	SRRM2_uc002crj.1_Missense_Mutation_p.S660L|SRRM2_uc002crl.1_Missense_Mutation_p.S756L|SRRM2_uc010bsu.1_Missense_Mutation_p.S660L	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	756	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CGCATTTCTTCAAGGCGGAGC	0.473													27	79					0	0	0.004656	0	0
PRSS22	64063	broad.mit.edu	37	16	2903974	2903974	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:2903974G>A	uc002cry.1	-	5	675	c.609C>T	c.(607-609)ATC>ATT	p.I203I	PRSS22_uc002crz.1_Silent_p.I93I	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	203	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						CTTCCGAGTCGATGATAGGAA	0.602													15	87					0	0	0.003163	0	0
CLDN9	9080	broad.mit.edu	37	16	3063921	3063921	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:3063921C>T	uc010uwo.1	+	1	1465	c.558C>T	c.(556-558)CCC>CCT	p.P186P		NM_020982	NP_066192	O95484	CLD9_HUMAN	claudin 9	186	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GCACGTGCCCCCCGCCCCAGG	0.721													6	47					0	0	0.001168	0	0
OR1F2P	26184	broad.mit.edu	37	16	3265954	3265954	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:3265954C>T	uc010uwv.1	+	1	393	c.245C>T	c.(244-246)GCT>GTT	p.A82V		NR_002169				RecName: Full=Olfactory receptor 1F2; AltName: Full=OLFmf2;												0						TTCCTCCTGGCTGTGATGGCC	0.512													4	40					0	0	0.000602	0	0
MEFV	4210	broad.mit.edu	37	16	3304166	3304166	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:3304166G>A	uc002cun.1	-	2	942	c.902C>T	c.(901-903)TCG>TTG	p.S301L		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	301					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	accggtgacCGAATGTTCTGG	0.313													5	53					0	0	0.000602	0	0
SRL	6345	broad.mit.edu	37	16	4242550	4242550	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:4242550G>A	uc002cvz.3	-	6	1039	c.1026C>T	c.(1024-1026)ATC>ATT	p.I342I	SRL_uc002cvy.3_RNA	NM_001098814	NP_001092284	Q86TD4	SRCA_HUMAN	sarcalumenin	801						sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5						GGAGGGCGTGGATGCGGACCC	0.517													15	133					0	0	0.004990	0	0
SRL	6345	broad.mit.edu	37	16	4242775	4242775	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:4242775C>T	uc002cvz.3	-	6	814	c.801G>A	c.(799-801)CGG>CGA	p.R267R	SRL_uc002cvy.3_RNA	NM_001098814	NP_001092284	Q86TD4	SRCA_HUMAN	sarcalumenin	726						sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5						CCCCGTAAACCCGCATGAGCA	0.552													5	60					0	0	0.000602	0	0
GLIS2	84662	broad.mit.edu	37	16	4384919	4384919	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:4384919G>A	uc002cwc.1	+	3	520	c.463G>A	c.(463-465)GAC>AAC	p.D155N		NM_032575	NP_115964	Q9BZE0	GLIS2_HUMAN	GLIS family zinc finger 2	155	Transcription repression (By similarity).|Interaction with CTNND1 (By similarity).				cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development	cytoplasm|nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|transcription regulatory region DNA binding|zinc ion binding				0						CCCTCCCAAGGACAAGTGCCT	0.652													4	52					0	0	0.000602	0	0
C16orf71	146562	broad.mit.edu	37	16	4793059	4793059	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:4793059G>A	uc002cxn.2	+	5	1261	c.799G>A	c.(799-801)GAT>AAT	p.D267N		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	267										central_nervous_system(1)	1						TGAAGCGTGGGATTTGGATGA	0.522													9	112					0	0	0.006214	0	0
UBN1	29855	broad.mit.edu	37	16	4924582	4924582	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:4924582C>T	uc002cyb.2	+	15	2510	c.2171C>T	c.(2170-2172)TCT>TTT	p.S724F	UBN1_uc010uxw.1_Missense_Mutation_p.S724F|UBN1_uc002cyc.2_Missense_Mutation_p.S724F	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	724					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						CCTAGTCCTTCTGCTCCACCA	0.498													20	214					0	0	0.003954	0	0
PPL	5493	broad.mit.edu	37	16	4945268	4945268	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:4945268C>T	uc002cyd.1	-	11	1326	c.1236G>A	c.(1234-1236)GGG>GGA	p.G412G		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	412	Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						GCACCTGCTCCCCCTCAAAGT	0.483													4	47					0	0	0.009096	0	0
A2BP1	54715	broad.mit.edu	37	16	7760716	7760716	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:7760716G>A	uc002cys.2	+	16	2151	c.1163G>A	c.(1162-1164)CGA>CAA	p.R388Q	A2BP1_uc002cyt.2_Missense_Mutation_p.R361Q|A2BP1_uc010uyb.1_Missense_Mutation_p.R388Q|A2BP1_uc002cyw.2_3'UTR|A2BP1_uc002cyy.2_Missense_Mutation_p.R409Q|A2BP1_uc002cyx.2_Missense_Mutation_p.R383Q|A2BP1_uc010uyc.1_Missense_Mutation_p.R382Q	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	388					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		AGTATATACCGAGGGGGATAC	0.438													15	43					0	0	0.004990	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857343	9857343	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:9857343C>T	uc002czo.3	-	13	4606	c.4058G>A	c.(4057-4059)AGG>AAG	p.R1353K	GRIN2A_uc010uym.1_Missense_Mutation_p.R1353K|GRIN2A_uc010uyn.1_Intron|GRIN2A_uc002czr.3_Intron	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1353	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGACTTGCTCCTCTTGCTGTC	0.542													11	35					0	0	0.008291	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858331	9858331	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:9858331C>T	uc002czo.3	-	13	3618	c.3070G>A	c.(3070-3072)GAT>AAT	p.D1024N	GRIN2A_uc010uym.1_Missense_Mutation_p.D1024N|GRIN2A_uc010uyn.1_Missense_Mutation_p.D867N|GRIN2A_uc002czr.3_Missense_Mutation_p.D1024N	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1024	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GATAGTGAATCCTGGCGTATG	0.542													12	112					0	0	0.010729	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858356	9858356	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:9858356C>T	uc002czo.3	-	13	3593	c.3045G>A	c.(3043-3045)AAG>AAA	p.K1015K	GRIN2A_uc010uym.1_Silent_p.K1015K|GRIN2A_uc010uyn.1_Silent_p.K858K|GRIN2A_uc002czr.3_Silent_p.K1015K	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1015	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCACGGATTTCTTCCACAGCT	0.532													5	83					0	0	0.000602	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858375	9858375	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:9858375C>T	uc002czo.3	-	13	3574	c.3026G>A	c.(3025-3027)AGA>AAA	p.R1009K	GRIN2A_uc010uym.1_Missense_Mutation_p.R1009K|GRIN2A_uc010uyn.1_Missense_Mutation_p.R852K|GRIN2A_uc002czr.3_Missense_Mutation_p.R1009K	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1009	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTGCCGGGGTCTAGAGTTCGC	0.507													23	50					0	0	0.014323	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858592	9858592	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:9858592C>T	uc002czo.3	-	13	3357	c.2809G>A	c.(2809-2811)GAT>AAT	p.D937N	GRIN2A_uc010uym.1_Missense_Mutation_p.D937N|GRIN2A_uc010uyn.1_Missense_Mutation_p.D780N|GRIN2A_uc002czr.3_Missense_Mutation_p.D937N	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	937	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTCCCCTTATCTGAAACCATG	0.453													16	116					0	0	0.004990	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858626	9858626	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:9858626G>A	uc002czo.3	-	13	3323	c.2775C>T	c.(2773-2775)ATC>ATT	p.I925I	GRIN2A_uc010uym.1_Silent_p.I925I|GRIN2A_uc010uyn.1_Silent_p.I768I|GRIN2A_uc002czr.3_Silent_p.I925I	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	925	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AACCTCTTTGGATGAAGTCAG	0.448													17	146					0	0	0.004990	0	0
GRIN2A	2903	broad.mit.edu	37	16	10032274	10032274	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:10032274G>A	uc002czo.3	-	3	1097	c.549C>T	c.(547-549)TTC>TTT	p.F183F	GRIN2A_uc010uym.1_Silent_p.F183F|GRIN2A_uc010uyn.1_Silent_p.F26F|GRIN2A_uc002czr.3_Silent_p.F183F	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	183	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.F183I(1)		skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGAAGCTGATGAATTCCCTGT	0.507													6	79					0	0	0.001984	0	0
TEKT5	146279	broad.mit.edu	37	16	10721508	10721508	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:10721508C>T	uc002czz.1	-	7	1462	c.1390G>A	c.(1390-1392)GAC>AAC	p.D464N		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	464					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						TTCTCCTTGTCGATGCAGAGG	0.667													7	56					0	0	0.004482	0	0
CIITA	4261	broad.mit.edu	37	16	10996552	10996552	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:10996552C>T	uc002dai.3	+	8	799	c.666C>T	c.(664-666)CTC>CTT	p.L222L	CIITA_uc002daj.3_Silent_p.L223L|CIITA_uc002dak.3_Silent_p.L173L|CIITA_uc002dag.2_Silent_p.L222L|CIITA_uc002dah.2_Silent_p.L174L|CIITA_uc010bup.1_Silent_p.L222L	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	222					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						GCCTGAATCTCCCTGAGGGAC	0.517			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								5	52					0	0	0.001168	0	0
CIITA	4261	broad.mit.edu	37	16	10996560	10996560	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:10996560G>A	uc002dai.3	+	8	807	c.674G>A	c.(673-675)GGA>GAA	p.G225E	CIITA_uc002daj.3_Missense_Mutation_p.G226E|CIITA_uc002dak.3_Missense_Mutation_p.G176E|CIITA_uc002dag.2_Missense_Mutation_p.G225E|CIITA_uc002dah.2_Missense_Mutation_p.G177E|CIITA_uc010bup.1_Missense_Mutation_p.G225E	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	225					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CTCCCTGAGGGACCCATCCAG	0.537			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								7	51					0	0	0.001984	0	0
CLEC16A	23274	broad.mit.edu	37	16	11063119	11063119	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:11063119C>A	uc002dao.2	+	4	675	c.445C>A	c.(445-447)CTT>ATT	p.L149I	CLEC16A_uc002dan.3_Missense_Mutation_p.L149I	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	149										ovary(1)|central_nervous_system(1)	2						CCTGAAAACACTTTCGTTAAA	0.363													3	18					0.004672	0.00502469	0.004672	1	0
KIAA0430	9665	broad.mit.edu	37	16	15730019	15730019	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:15730019G>A	uc002ddr.2	-	3	518	c.325C>T	c.(325-327)CCC>TCC	p.P109S	KIAA0430_uc002ddq.2_Missense_Mutation_p.P108S|KIAA0430_uc010uzv.1_Missense_Mutation_p.P108S|KIAA0430_uc010uzw.1_Missense_Mutation_p.P108S|KIAA0430_uc010uzx.1_Missense_Mutation_p.P108S	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	108						peroxisome	nucleotide binding|RNA binding				0						GAAGTGGAGGGTTCATTAGGG	0.527													15	59					0	0	0.006122	0	0
MYH11	4629	broad.mit.edu	37	16	15847301	15847301	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:15847301G>A	uc002ddy.2	-	15	1921	c.1814C>T	c.(1813-1815)TCC>TTC	p.S605F	MYH11_uc002ddv.2_Missense_Mutation_p.S612F|MYH11_uc002ddw.2_Missense_Mutation_p.S605F|MYH11_uc002ddx.2_Missense_Mutation_p.S612F|MYH11_uc010bvg.2_Missense_Mutation_p.S437F|MYH11_uc002dea.1_Missense_Mutation_p.S311F	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	605	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						ATTGAGCAGGGAAGTCACGTT	0.557			T	CBFB	AML								7	69					0	0	0.003080	0	0
ABCC6	368	broad.mit.edu	37	16	16302666	16302666	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:16302666G>A	uc002den.3	-	7	750	c.713C>T	c.(712-714)TCG>TTG	p.S238L	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Missense_Mutation_p.S250L	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	238	Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TCTCCCAAGCGACCAGAGGTC	0.557													4	30					0	0	0.001168	0	0
CP110	9738	broad.mit.edu	37	16	19548407	19548407	+	Silent	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:19548407A>G	uc002dgl.3	+	4	1663	c.1416A>G	c.(1414-1416)AAA>AAG	p.K472K	CP110_uc002dgk.3_Silent_p.K472K			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	472	Interaction with CEP76.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						TAGAAAATAAAGTTACTCATG	0.393													4	34					0	0	0.009096	0	0
C16orf88	400506	broad.mit.edu	37	16	19725860	19725860	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:19725860G>A	uc002dgq.2	-	2	513	c.498C>T	c.(496-498)GTC>GTT	p.V166V	IQCK_uc002dgr.2_5'Flank|IQCK_uc002dgs.2_5'Flank	NM_001012991	NP_001013009	Q1ED39	CP088_HUMAN	hypothetical protein LOC400506	166	Lys-rich.					nucleolus					0						AAGGGTCCTGGACCGAGAAGG	0.567													5	46					0	0	0.001984	0	0
GPR139	124274	broad.mit.edu	37	16	20043735	20043735	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:20043735G>A	uc002dgu.1	-	2	546	c.384C>T	c.(382-384)ATC>ATT	p.I128I	GPR139_uc010vaw.1_Silent_p.I35I	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	128	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						GGCAGACAGCGATATACCTGT	0.507													12	88					0	0	0.010729	0	0
GP2	2813	broad.mit.edu	37	16	20335565	20335565	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:20335565G>A	uc002dgv.2	-	3	191	c.108C>T	c.(106-108)CCC>CCT	p.P36P	GP2_uc002dgw.2_Silent_p.P36P|GP2_uc002dgx.2_Intron|GP2_uc002dgy.2_Intron	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	36						anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						TGGCTTCAATGGGGTTTCCAT	0.522													5	32					0	0	0.001168	0	0
ACSM2A	123876	broad.mit.edu	37	16	20489907	20489907	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:20489907G>A	uc010bwe.2	+	11	1428	c.1189G>A	c.(1189-1191)GAT>AAT	p.D397N	ACSM2A_uc010vax.1_Missense_Mutation_p.D318N|ACSM2A_uc002dhf.3_Missense_Mutation_p.D397N|ACSM2A_uc002dhg.3_Missense_Mutation_p.D397N|ACSM2A_uc010vay.1_Missense_Mutation_p.D318N|ACSM2A_uc002dhh.3_Missense_Mutation_p.D27N	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	397					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GATCATAGATGATAAGGGCAA	0.478													6	46					0	0	0.001168	0	0
ACSM2B	348158	broad.mit.edu	37	16	20548602	20548602	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:20548602G>A	uc002dhj.3	-	15	1922	c.1712C>T	c.(1711-1713)TCC>TTC	p.S571F	ACSM2B_uc002dhk.3_Missense_Mutation_p.S571F	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	571					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GGCTTTTCCGGACATCTTCCA	0.458													17	179					0	0	0.006122	0	0
ACSM2B	348158	broad.mit.edu	37	16	20551980	20551980	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:20551980C>T	uc002dhj.3	-	14	1835	c.1625G>A	c.(1624-1626)AGA>AAA	p.R542K	ACSM2B_uc002dhk.3_Missense_Mutation_p.R542K	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	542	Coenzyme A binding (By similarity).				fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CCTTACCTTTCTTGGGTACTT	0.468													28	56					0	0	0.012213	0	0
DNAH3	55567	broad.mit.edu	37	16	20975047	20975047	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:20975047C>T	uc010vbe.1	-	53	10159	c.10159G>A	c.(10159-10161)GAA>AAA	p.E3387K	DNAH3_uc010vbd.1_Missense_Mutation_p.E822K	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3387					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCCGTAATTTCCTTCTTCTGT	0.517													4	39					0	0	0.000602	0	0
DNAH3	55567	broad.mit.edu	37	16	20999290	20999290	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:20999290C>T	uc010vbe.1	-	45	6699	c.6699G>A	c.(6697-6699)GGG>GGA	p.G2233G	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2233	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CAAACCCTTTCCCGAAGTGCC	0.453													8	35					0	0	0.004482	0	0
DNAH3	55567	broad.mit.edu	37	16	21053493	21053493	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:21053493G>A	uc010vbe.1	-	32	4494	c.4494C>T	c.(4492-4494)ATC>ATT	p.I1498I		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1498	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GGATGCTGAGGATCTGCTGAG	0.517													7	70					0	0	0.001984	0	0
DNAH3	55567	broad.mit.edu	37	16	21139089	21139089	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:21139089C>T	uc010vbe.1	-	8	1127	c.1127G>A	c.(1126-1128)GGA>GAA	p.G376E	DNAH3_uc002die.2_Missense_Mutation_p.G347E	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	376	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGGCAATTTTCCCGCTAGTAT	0.458													10	107					0	0	0.010729	0	0
TMEM159	57146	broad.mit.edu	37	16	21181780	21181780	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:21181780C>T	uc002dif.3	+	3	480	c.119C>T	c.(118-120)CCA>CTA	p.P40L	TMEM159_uc002dig.3_RNA|TMEM159_uc010vbf.1_Missense_Mutation_p.P64L|TMEM159_uc002dih.3_Missense_Mutation_p.P40L	NM_020422	NP_065155	Q96B96	TM159_HUMAN	transmembrane protein 159	40						integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0972)		ATGAAGTCTCCAGTGGGTCAG	0.522													17	142					0	0	0.014323	0	0
OTOA	146183	broad.mit.edu	37	16	21689852	21689852	+	Missense_Mutation	SNP	C	T	T	rs144912852		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:21689852C>T	uc002djh.2	+	1	18	c.17C>T	c.(16-18)ACG>ATG	p.T6M	uc002diq.3_Intron	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	6					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		CAGGAACCTACGACATACTCC	0.333													6	57					0	0	0.004482	0	0
USP31	57478	broad.mit.edu	37	16	23096193	23096193	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:23096193G>A	uc002dll.2	-	11	1818	c.1818C>T	c.(1816-1818)ACC>ACT	p.T606T	USP31_uc010bxm.2_5'UTR	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	606					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		GCTCCTCTTTGGTGTACAGTT	0.512													22	196					0	0	0.012319	0	0
SCNN1G	6340	broad.mit.edu	37	16	23208648	23208648	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:23208648G>A	uc002dlm.1	+	6	1116	c.977G>A	c.(976-978)GGA>GAA	p.G326E		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	326	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TCCTCCACTGGAGCTAAGGTG	0.488													4	53					0	0	0.000602	0	0
PRKCB	5579	broad.mit.edu	37	16	24166021	24166021	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:24166021G>A	uc002dmd.2	+	10	1279	c.1082G>A	c.(1081-1083)CGA>CAA	p.R361Q	PRKCB_uc002dme.2_Missense_Mutation_p.R361Q	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	361	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CTTTCAGAACGAAAAGGCACA	0.507													10	27					0	0	0.010729	0	0
CACNG3	10368	broad.mit.edu	37	16	24372779	24372779	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:24372779C>T	uc002dmf.2	+	4	1743	c.543C>T	c.(541-543)TTC>TTT	p.F181F		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	181	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		CCTTTTATTTCGGAGCCTTCT	0.458													11	124					0	0	0.008291	0	0
RBBP6	5930	broad.mit.edu	37	16	24582700	24582700	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:24582700G>A	uc002dmh.2	+	18	5353	c.4313G>A	c.(4312-4314)GGA>GAA	p.G1438E	RBBP6_uc002dmi.2_Missense_Mutation_p.G1404E|RBBP6_uc010bxr.2_Missense_Mutation_p.G598E|RBBP6_uc002dmk.2_Missense_Mutation_p.G1271E	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1438	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		AATGAACAAGGAAATTTTAAA	0.403													10	40					0	0	0.006214	0	0
RBBP6	5930	broad.mit.edu	37	16	24582793	24582793	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:24582793C>T	uc002dmh.2	+	18	5446	c.4406C>T	c.(4405-4407)CCC>CTC	p.P1469L	RBBP6_uc002dmi.2_Missense_Mutation_p.P1435L|RBBP6_uc010bxr.2_Missense_Mutation_p.P629L|RBBP6_uc002dmk.2_Missense_Mutation_p.P1302L	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1469	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GACTTCACTCCCAATAGAGAC	0.368													5	33					0	0	0.001984	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147239	26147239	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:26147239C>T	uc002dof.2	+	2	1433	c.1041C>T	c.(1039-1041)TTC>TTT	p.F347F		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	347	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		TCCAGTATTTCCCCCTCTCCC	0.537													11	92					0	0	0.008291	0	0
GTF3C1	2975	broad.mit.edu	37	16	27556757	27556757	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:27556757G>A	uc002dov.1	-	2	349	c.309C>T	c.(307-309)ATC>ATT	p.I103I	GTF3C1_uc002dou.2_Silent_p.I103I	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	103						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TATTCTCTAAGATCATATGAA	0.443													14	33					0	0	0.002450	0	0
GTF3C1	2975	broad.mit.edu	37	16	27561109	27561109	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:27561109A>G	uc002dov.1	-	1	143	c.103T>C	c.(103-105)TTC>CTC	p.F35L	GTF3C1_uc002dou.2_Missense_Mutation_p.F35L|KIAA0556_uc002dow.2_5'Flank	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	35						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GGCAGCGGGAAGGGCGGCACT	0.677													6	23					0	0	0.001984	0	0
TAOK2	9344	broad.mit.edu	37	16	29998403	29998403	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:29998403C>T	uc002dva.1	+	16	3593	c.2810C>T	c.(2809-2811)CCC>CTC	p.P937L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_Missense_Mutation_p.P944L|TAOK2_uc002dvd.1_Missense_Mutation_p.P764L	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	937					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CACCTGAGGCCCTGCCCTGCC	0.662													11	109					0	0	0.010729	0	0
ITGAL	3683	broad.mit.edu	37	16	30529171	30529171	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:30529171C>T	uc002dyi.3	+	28	3263	c.3087C>T	c.(3085-3087)ATC>ATT	p.I1029I	ITGAL_uc002dyj.3_Silent_p.I945I|ITGAL_uc010vev.1_Silent_p.I263I	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	1029	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GGCAGGAGATCCTCGTCCAAG	0.627													9	64					0	0	0.004482	0	0
ITGAL	3683	broad.mit.edu	37	16	30532878	30532878	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:30532878C>T	uc002dyi.3	+	31	3581	c.3405C>T	c.(3403-3405)ATC>ATT	p.I1135I	ITGAL_uc002dyj.3_Silent_p.I1051I|ITGAL_uc010vev.1_Silent_p.I369I	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	1135	Cytoplasmic (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	CGAATGGAATCCCTGCAGAAG	0.532													8	48					0	0	0.004482	0	0
ZNF768	79724	broad.mit.edu	37	16	30536709	30536709	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:30536709C>T	uc002dyk.3	-	2	928	c.752G>A	c.(751-753)CGG>CAG	p.R251Q	ZNF768_uc010vex.1_Missense_Mutation_p.R220Q|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.R220Q	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	251					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						ACCCCTGGCCCGGCCACCCCG	0.667													6	29					0	0	0.001984	0	0
VPS35	55737	broad.mit.edu	37	16	46696963	46696963	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:46696963C>T	uc002eef.3	-	14	1858	c.1759G>A	c.(1759-1761)GGA>AGA	p.G587R	VPS35_uc002eed.2_Missense_Mutation_p.G408R|VPS35_uc002eee.2_Missense_Mutation_p.G548R	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	587					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GCTAGTGCTCCTTGAAGAAAA	0.423													4	28					0	0	0.009096	0	0
NETO2	81831	broad.mit.edu	37	16	47143563	47143563	+	Silent	SNP	G	A	A	rs139454743		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:47143563G>A	uc002eer.1	-	7	1099	c.714C>T	c.(712-714)TTC>TTT	p.F238F	NETO2_uc002eeq.1_Silent_p.F11F|NETO2_uc010vgf.1_Silent_p.F95F|NETO2_uc002ees.1_Silent_p.F231F	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	238	Extracellular (Potential).|CUB 2.					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				AGACTGCAACGAAGTTTCTCT	0.353										HNSCC(25;0.065)			6	53					0	0	0.006214	0	0
ABCC12	94160	broad.mit.edu	37	16	48162523	48162523	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:48162523C>T	uc002efc.1	-	9	1708	c.1362G>A	c.(1360-1362)AAG>AAA	p.K454K	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Silent_p.K454K	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	454						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TCTGCAATTTCTTTGGGGTAC	0.498													7	36					0	0	0.001984	0	0
HEATR3	55027	broad.mit.edu	37	16	50136230	50136230	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:50136230G>A	uc002efw.2	+	14	1966	c.1804G>A	c.(1804-1806)GAA>AAA	p.E602K	HEATR3_uc002efx.2_Missense_Mutation_p.E516K	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	602							binding			ovary(1)|skin(1)	2						GGTAGCAGGAGAAGCTTTGGA	0.408													12	71					0	0	0.001855	0	0
CYLD	1540	broad.mit.edu	37	16	50811837	50811837	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:50811837T>G	uc002egp.1	+	8	1538	c.1123T>G	c.(1123-1125)TGG>GGG	p.W375G	CYLD_uc002egn.1_Missense_Mutation_p.W372G|CYLD_uc002ego.2_Missense_Mutation_p.W372G|CYLD_uc010cbs.1_Missense_Mutation_p.W372G|CYLD_uc002egq.1_Missense_Mutation_p.W372G|CYLD_uc002egr.1_Missense_Mutation_p.W372G|CYLD_uc002egs.1_Missense_Mutation_p.W372G	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	375	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				AAAAAATACATGGTACATTGA	0.299			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				5	43					0	0	0.000602	0	0
SALL1	6299	broad.mit.edu	37	16	51171260	51171260	+	Silent	SNP	C	T	T	rs145953478		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:51171260C>T	uc010vgs.1	-	3	3769	c.3738G>A	c.(3736-3738)GCG>GCA	p.A1246A	SALL1_uc010vgr.1_Silent_p.A1149A|SALL1_uc010cbv.2_Silent_p.A98A	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1246					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGCCTTCATCGCCAGCCCGT	0.562													6	32					0	0	0.001168	0	0
CHD9	80205	broad.mit.edu	37	16	53190396	53190396	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:53190396C>T	uc002ehb.2	+	1	559	c.395C>T	c.(394-396)ACC>ATC	p.T132I	CHD9_uc002egy.2_Missense_Mutation_p.T132I|CHD9_uc002egz.1_Missense_Mutation_p.T132I|CHD9_uc002eha.1_Missense_Mutation_p.T132I|CHD9_uc002ehc.2_Missense_Mutation_p.T132I	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	132					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				ACAGCTACTACCATTTCAAAT	0.408													12	114					0	0	0.001855	0	0
CHD9	80205	broad.mit.edu	37	16	53191228	53191228	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:53191228C>T	uc002ehb.2	+	1	1391	c.1227C>T	c.(1225-1227)CTC>CTT	p.L409L	CHD9_uc002egy.2_Silent_p.L409L|CHD9_uc002egz.1_Silent_p.L409L|CHD9_uc002eha.1_Silent_p.L409L|CHD9_uc002ehc.2_Silent_p.L409L	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	409					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CCGAGGACCTCCTTCAGGAGG	0.413													4	13					0	0	0.009096	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53675298	53675298	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:53675298C>T	uc002ehp.2	-	18	2837	c.2773G>A	c.(2773-2775)GGA>AGA	p.G925R	RPGRIP1L_uc002eho.3_Missense_Mutation_p.G925R|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.G925R|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.G925R|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.G925R	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	925					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				GTTATTGATCCACTTGGTGGA	0.393													48	388					0	0	0.014410	0	0
RSPRY1	89970	broad.mit.edu	37	16	57238655	57238655	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:57238655C>T	uc002elb.2	+	2	363	c.85C>T	c.(85-87)CAC>TAC	p.H29Y	RSPRY1_uc002elc.2_Missense_Mutation_p.H29Y|RSPRY1_uc002eld.2_Missense_Mutation_p.H29Y|RSPRY1_uc002ele.1_Missense_Mutation_p.H29Y	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	29						extracellular region	zinc ion binding			ovary(1)	1						GCACATAGCCCACTTCCTAGG	0.507													24	108					0	0	0.003330	0	0
CNGB1	1258	broad.mit.edu	37	16	58001095	58001095	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:58001095C>T	uc002emt.2	-	2	161	c.96G>A	c.(94-96)GAG>GAA	p.E32E	CNGB1_uc010cdh.2_Silent_p.E32E|CNGB1_uc002emu.2_Silent_p.E32E	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	32	Glu-rich.				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						CCGCCTCCATCTCTGGCTCTG	0.637													4	32					0	0	0.001168	0	0
CES8	283848	broad.mit.edu	37	16	67039179	67039179	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:67039179G>A	uc002eqv.2	+	10	1160	c.1117G>A	c.(1117-1119)GAG>AAG	p.E373K	CES8_uc010vix.1_Missense_Mutation_p.E400K|CES8_uc002eqw.2_Missense_Mutation_p.E373K|CES8_uc002eqy.2_Missense_Mutation_p.E302K|CES8_uc002eqx.2_Missense_Mutation_p.E206K|CES8_uc010viy.1_Missense_Mutation_p.E306K|CES8_uc010viz.1_Missense_Mutation_p.E302K|CES8_uc002eqz.2_5'Flank	NM_173815	NP_776176	Q5XG92	EST4A_HUMAN	carboxylesterase 8 (putative)	400						extracellular region	carboxylesterase activity				0						TGTGGTGGAGGAGTACCTGGA	0.537													5	65					0	0	0.001984	0	0
PDPR	55066	broad.mit.edu	37	16	70176283	70176283	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:70176283C>T	uc002eyf.1	+	12	2419	c.1462C>T	c.(1462-1464)CCC>TCC	p.P488S	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.P388S|PDPR_uc002eyg.1_Missense_Mutation_p.P216S	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	488					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		CTTTGTTCCCCCCGACAAGGG	0.428													4	66					0	0	0.000602	0	0
DDX19B	11269	broad.mit.edu	37	16	70363946	70363946	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:70363946T>A	uc002eyo.2	+	9	1127	c.998T>A	c.(997-999)ATT>AAT	p.I333N	DDX19B_uc010vly.1_Missense_Mutation_p.I333N|DDX19A_uc002eys.2_Intron|DDX19B_uc010vlv.1_Missense_Mutation_p.I307N|DDX19B_uc010vlw.1_Missense_Mutation_p.I224N|DDX19B_uc002eyp.2_Missense_Mutation_p.I302N|DDX19B_uc002eyq.2_Missense_Mutation_p.I224N|DDX19B_uc002eyr.2_Missense_Mutation_p.I182N|DDX19B_uc010vlx.1_Missense_Mutation_p.I182N|uc002eyt.2_Intron	NM_007242	NP_009173	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform	333	Helicase C-terminal.				mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			kidney(1)	1		Ovarian(137;0.0694)				GCCATCACCATTGCTCAAGCC	0.577													9	71					0	0	0.004482	0	0
DDX19B	11269	broad.mit.edu	37	16	70363949	70363949	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:70363949C>T	uc002eyo.2	+	9	1130	c.1001C>T	c.(1000-1002)GCT>GTT	p.A334V	DDX19B_uc010vly.1_Missense_Mutation_p.A334V|DDX19A_uc002eys.2_Intron|DDX19B_uc010vlv.1_Missense_Mutation_p.A308V|DDX19B_uc010vlw.1_Missense_Mutation_p.A225V|DDX19B_uc002eyp.2_Missense_Mutation_p.A303V|DDX19B_uc002eyq.2_Missense_Mutation_p.A225V|DDX19B_uc002eyr.2_Missense_Mutation_p.A183V|DDX19B_uc010vlx.1_Missense_Mutation_p.A183V|uc002eyt.2_Intron	NM_007242	NP_009173	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform	334	Helicase C-terminal.				mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			kidney(1)	1		Ovarian(137;0.0694)				ATCACCATTGCTCAAGCCATG	0.582													8	66					0	0	0.004482	0	0
HYDIN	54768	broad.mit.edu	37	16	71212846	71212846	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:71212846C>T	uc002ezr.2	-	4	494	c.366G>A	c.(364-366)TTG>TTA	p.L122L	HYDIN_uc010cfz.1_5'UTR|HYDIN_uc002ezv.2_Silent_p.L122L|HYDIN_uc010vmc.1_Silent_p.L139L|HYDIN_uc010vmd.1_Silent_p.L149L|HYDIN_uc002ezw.3_Silent_p.L139L	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	122										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CATTGTTCCTCAAAATCAGTG	0.403													8	90					0	0	0.004482	0	0
CHST4	10164	broad.mit.edu	37	16	71571297	71571297	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:71571297G>A	uc002fan.2	+	2	898	c.717G>A	c.(715-717)GAG>GAA	p.E239E	CHST4_uc002fao.2_Silent_p.E239E	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	239	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						TCAAGAAGGAGGACCAACCCT	0.552											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	22					0	0	0.004672	0	0
CHST4	10164	broad.mit.edu	37	16	71571469	71571469	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:71571469G>A	uc002fan.2	+	2	1070	c.889G>A	c.(889-891)GAA>AAA	p.E297K	CHST4_uc002fao.2_Missense_Mutation_p.E297K	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	297	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						CGTGGGATTGGAATTCTTGCC	0.567											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	16					0	0	0.000602	0	0
PMFBP1	83449	broad.mit.edu	37	16	72163055	72163055	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:72163055C>T	uc002fcc.3	-	13	2047	c.1875G>A	c.(1873-1875)CGG>CGA	p.R625R	PMFBP1_uc002fcd.2_Silent_p.R620R|PMFBP1_uc002fce.2_Intron|PMFBP1_uc002fcf.2_Silent_p.R475R|PMFBP1_uc010cgo.1_5'Flank	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	625	Potential.									ovary(2)	2		Ovarian(137;0.179)				TCAACTGCTCCCGTTTGTCCT	0.463													28	241					0	0	0.005443	0	0
MLKL	197259	broad.mit.edu	37	16	74729605	74729605	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:74729605C>T	uc002fdb.2	-	2	492	c.51G>A	c.(49-51)CGG>CGA	p.R17R	MLKL_uc002fdc.2_Silent_p.R17R	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	17							ATP binding|protein binding|protein kinase activity			stomach(2)	2						TCTCTTCACACCGTTTGTGGA	0.498													4	35					0	0	0.009096	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76461444	76461444	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:76461444G>A	uc002feu.1	+	6	871	c.486G>A	c.(484-486)TGG>TGA	p.W162*	CNTNAP4_uc002fev.1_Nonsense_Mutation_p.W74*|CNTNAP4_uc010chb.1_Nonsense_Mutation_p.W137*|CNTNAP4_uc002fex.1_Nonsense_Mutation_p.W165*|CNTNAP4_uc002few.2_Nonsense_Mutation_p.W137*	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	162	Extracellular (Potential).|F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CTTTGGAATGGAACCCCAAGG	0.413													6	75					0	0	0.001168	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401457	77401457	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:77401457G>A	uc002ffc.3	-	4	1078	c.659C>T	c.(658-660)TCT>TTT	p.S220F	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	220					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						ATTCCGGCCAGAGCCGGGGTA	0.532													6	36					0	0	0.001168	0	0
CDYL2	124359	broad.mit.edu	37	16	80646658	80646658	+	Silent	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:80646658A>C	uc002ffs.2	-	5	1188	c.1083T>G	c.(1081-1083)GGT>GGG	p.G361G		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	361						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						GGATGGAGGCACCCAGGCCCA	0.602													5	47					0	0	0.001168	0	0
PKD1L2	114780	broad.mit.edu	37	16	81249950	81249950	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:81249950G>A	uc002fgh.1	-	2	363	c.363C>T	c.(361-363)GCC>GCT	p.A121A	PKD1L2_uc002fgj.2_Silent_p.A121A	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	121	Extracellular (Potential).|C-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGGCAGCGGCGGCCTGCCCTC	0.637													4	49					0	0	0.000602	0	0
ADAD2	161931	broad.mit.edu	37	16	84229791	84229791	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:84229791G>A	uc002fhr.2	+	8	1455	c.1341G>A	c.(1339-1341)CTG>CTA	p.L447L	ADAD2_uc002fhq.2_Silent_p.L529L|uc002fhs.1_Intron	NM_001145400	NP_001138872	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2 isoform	447	A to I editase.				RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding				0						GGCCCTGCCTGGACAGTGTCC	0.677													4	70					0	0	0.000602	0	0
ATP2C2	9914	broad.mit.edu	37	16	84459400	84459400	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:84459400G>A	uc002fhx.2	+	11	1068	c.979G>A	c.(979-981)GGG>AGG	p.G327R	ATP2C2_uc010chj.2_Missense_Mutation_p.G327R|ATP2C2_uc002fhy.2_Missense_Mutation_p.G344R|ATP2C2_uc002fhz.2_Missense_Mutation_p.G176R	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	327	Cytoplasmic (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						GTTCACGATCGGGGTCAGGTA	0.547													23	144					0	0	0.003954	0	0
FOXL1	2300	broad.mit.edu	37	16	86613328	86613328	+	Silent	SNP	C	T	T	rs138392858	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:86613328C>T	uc002fjr.2	+	1	1214	c.999C>T	c.(997-999)TTC>TTT	p.F333F		NM_005250	NP_005241	Q12952	FOXL1_HUMAN	forkhead box L1	333					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1						TCTCTTATTTCCCCCTGCAGG	0.607													5	26					0	0	0.001168	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351875	89351875	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:89351875G>A	uc002fmx.1	-	9	1536	c.1075C>T	c.(1075-1077)CCT>TCT	p.P359S	ANKRD11_uc002fmy.1_Missense_Mutation_p.P359S|ANKRD11_uc002fnc.1_Missense_Mutation_p.P359S|ANKRD11_uc002fnb.1_Missense_Mutation_p.P316S	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	359						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCCACCGGAGGAACCCTGTCC	0.488													11	96					0	0	0.010729	0	0
TUBB3	10381	broad.mit.edu	37	16	90002125	90002125	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr16:90002125C>T	uc002fph.1	+	4	1331	c.1266C>T	c.(1264-1266)TAC>TAT	p.Y422Y	TUBB3_uc002fpf.2_Silent_p.Y769Y|TUBB3_uc010ciz.1_Silent_p.Y350Y|TUBB3_uc002fpg.1_Silent_p.Y276Y|TUBB3_uc002fpi.1_Silent_p.Y350Y|TUBB3_uc002fpj.1_Silent_p.Y350Y|TUBB3_uc010cjb.1_Silent_p.Y276Y|TUBB3_uc002fpk.1_Silent_p.Y276Y	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	422					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		TGTCCGAGTACCAGCAGTACC	0.642													6	31					0	0	0.001168	0	0
C17orf97	400566	broad.mit.edu	37	17	263309	263309	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:263309C>T	uc002frh.2	+	3	721	c.705C>T	c.(703-705)TTC>TTT	p.F235F	C17orf97_uc010vpz.1_RNA	NM_001013672	NP_001013694	Q6ZQX7	CQ097_HUMAN	hypothetical protein LOC400566	235	4.|20 X 10 AA approximative tandem repeat of A-L-K-G-F-H-P-D-P-E.									ovary(1)	1						TCAAGGGCTTCCACCCCGACC	0.701													5	27					0	0	0.000602	0	0
CRK	1398	broad.mit.edu	37	17	1340197	1340197	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:1340197G>A	uc002fsl.2	-	2	627	c.494C>T	c.(493-495)CCT>CTT	p.P165L	CRK_uc002fsm.2_Missense_Mutation_p.P165L	NM_016823	NP_058431	P46108	CRK_HUMAN	v-crk sarcoma virus CT10 oncogene homolog	165	SH3 1.				actin cytoskeleton organization|activation of MAPKK activity|blood coagulation|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of transcription from RNA polymerase II promoter	cytosol|endosome|nucleus|plasma membrane	protein binding|SH2 domain binding			lung(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (25;0.083)		CTGCTCTTCAGGCTTGTCCCG	0.517													24	58					0	0	0.006320	0	0
SCARF1	8578	broad.mit.edu	37	17	1538059	1538059	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:1538059T>C	uc002fsz.1	-	11	2536	c.2486A>G	c.(2485-2487)GAA>GGA	p.E829G	SCARF1_uc002fsy.1_3'UTR|SCARF1_uc002fta.1_RNA|SCARF1_uc010cjv.1_Missense_Mutation_p.E743G	NM_003693	NP_003684	Q14162	SREC_HUMAN	scavenger receptor class F, member 1 isoform 1	829	Cytoplasmic (Potential).				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TCATCAGGGTTCTGGTGGCCT	0.557													32	92					0	0	0.003755	0	0
OR1D2	4991	broad.mit.edu	37	17	2996055	2996055	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:2996055G>A	uc010vrb.1	-	1	236	c.236C>T	c.(235-237)CCC>CTC	p.P79L		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	79	Helical; Name=2; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CAGCATCTTGGGGATTGTGTT	0.547													16	126					0	0	0.006122	0	0
OR1D2	4991	broad.mit.edu	37	17	2996057	2996057	+	Silent	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:2996057G>T	uc010vrb.1	-	1	234	c.234C>A	c.(232-234)ATC>ATA	p.I78I		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	78	Helical; Name=2; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GCATCTTGGGGATTGTGTTGG	0.547													17	126					2.94398e-08	3.18773e-08	0.007413	1	0
OR1D2	4991	broad.mit.edu	37	17	2996212	2996212	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:2996212G>A	uc010vrb.1	-	1	79	c.79C>T	c.(79-81)CTG>TTG	p.L27L		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	27	Helical; Name=1; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						ATCCAAAACAGGATCCGCTGC	0.532													6	79					0	0	0.001168	0	0
OR3A2	4995	broad.mit.edu	37	17	3181660	3181660	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:3181660G>A	uc002fvg.2	-	1	609	c.570C>T	c.(568-570)CTC>CTT	p.L190L		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	190	Extracellular (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						AGAGCTGTGGGAGGTCACAGT	0.547													10	49					0	0	0.008291	0	0
OR3A1	4994	broad.mit.edu	37	17	3195080	3195080	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:3195080C>T	uc002fvh.1	-	1	797	c.797G>A	c.(796-798)GGT>GAT	p.G266D		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						CTTGGTTGAACCCAGTCGCAT	0.448													7	65					0	0	0.001984	0	0
OR1E1	8387	broad.mit.edu	37	17	3301098	3301098	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:3301098C>T	uc002fvj.1	-	1	607	c.607G>A	c.(607-609)GGA>AGA	p.G203R		NM_003553	NP_003544	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATGAGCCCTCCCATGATAAAT	0.463													4	15					0	0	0.001168	0	0
P2RX5	5026	broad.mit.edu	37	17	3585200	3585200	+	Missense_Mutation	SNP	C	T	T	rs1131057	by1000genomes	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:3585200C>T	uc002fwi.2	-	10	1338	c.1054G>A	c.(1054-1056)GAG>AAG	p.E352K	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Missense_Mutation_p.E351K|P2RX5_uc010vrx.1_Missense_Mutation_p.E292K|P2RX5_uc002fwj.2_Missense_Mutation_p.E327K|P2RX5_uc002fwk.2_Missense_Mutation_p.E351K|P2RX5_uc002fwl.2_Missense_Mutation_p.E328K	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	352	Cytoplasmic (Potential).			E -> Q (in Ref. 1; AAB08576/AAB08577).	nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						CTCACTTCCTCGTACTTCTTG	0.547													4	17					0	0	0.009096	0	0
ITGAE	3682	broad.mit.edu	37	17	3662736	3662736	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:3662736C>T	uc002fwo.3	-	8	925	c.826G>A	c.(826-828)GGG>AGG	p.G276R		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	276	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GTGACACTCCCCACTTGAGTG	0.557													6	54					0	0	0.003080	0	0
P2RX1	5023	broad.mit.edu	37	17	3802950	3802950	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:3802950G>A	uc002fww.2	-	8	1294	c.853C>T	c.(853-855)CTC>TTC	p.L285F		NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	285	Extracellular (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		CCTGGGGAGAGATTTTTCTCT	0.552													4	28					0	0	0.009096	0	0
PELP1	27043	broad.mit.edu	37	17	4607321	4607321	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:4607321G>A	uc002fyi.3	-	1	312	c.86C>T	c.(85-87)TCG>TTG	p.S29L	PELP1_uc010vsf.1_5'UTR	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	29					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						CCGCGGGCCCGAGCTCACTGC	0.701													10	20					0	0	0.010729	0	0
ZMYND15	84225	broad.mit.edu	37	17	4647762	4647762	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:4647762G>A	uc002fyt.2	+	9	1605	c.1566G>A	c.(1564-1566)AGG>AGA	p.R522R	ZMYND15_uc002fyv.2_Silent_p.R561R|ZMYND15_uc002fyu.2_Silent_p.R561R	NM_032265	NP_115641	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15 isoform 2	522							zinc ion binding				0						CCCTGCAGAGGGTGAGGGCTG	0.637													12	29					0	0	0.010729	0	0
FBXO39	162517	broad.mit.edu	37	17	6690203	6690203	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:6690203C>T	uc010vtg.1	+	3	1248	c.1128C>T	c.(1126-1128)TTC>TTT	p.F376F	FBXO39_uc010cls.1_RNA	NM_153230	NP_694962	Q8N4B4	FBX39_HUMAN	F-box protein 39	376										ovary(1)|skin(1)	2						TCTGGGCTTTCCTTGATGTTA	0.483													6	37					0	0	0.001984	0	0
MPDU1	9526	broad.mit.edu	37	17	7487252	7487253	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:7487252_7487253CC>TT	uc002ghw.2	+	1	288_289	c.72_73CC>TT	c.(70-75)GACCAA>GATTAA	p.Q25*	MPDU1_uc010vub.1_5'UTR|MPDU1_uc002ghx.2_Nonsense_Mutation_p.Q25*|MPDU1_uc010vuc.1_Nonsense_Mutation_p.Q25*	NM_004870	NP_004861	O75352	MPU1_HUMAN	mannose-P-dolichol utilization defect 1	25					dolichol-linked oligosaccharide biosynthetic process|protein folding	endoplasmic reticulum membrane|integral to membrane|mitochondrion	protein binding			central_nervous_system(1)	1						AATGCTACGACCAACTTTTCGT	0.535													19	112					0	0	0.004672	0	0
DNAH2	146754	broad.mit.edu	37	17	7662354	7662354	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:7662354C>T	uc002giu.1	+	14	2374	c.2360C>T	c.(2359-2361)GCT>GTT	p.A787V		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	787	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CATCGGGCAGCTGTACAGCAG	0.507													4	21					0	0	0.009096	0	0
DNAH2	146754	broad.mit.edu	37	17	7733619	7733619	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:7733619G>A	uc002giu.1	+	77	11869	c.11855G>A	c.(11854-11856)GGC>GAC	p.G3952D	DNAH2_uc010cnm.1_Missense_Mutation_p.G890D	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3952	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGTCCCCAGGGCCTAAAGGCC	0.383													5	35					0	0	0.000602	0	0
ALOX15B	247	broad.mit.edu	37	17	7948190	7948190	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:7948190C>T	uc002gju.2	+	6	836	c.720C>T	c.(718-720)TCC>TCT	p.S240S	ALOX15B_uc002gjv.2_Silent_p.S240S|ALOX15B_uc002gjw.2_Silent_p.S240S|ALOX15B_uc010vun.1_Silent_p.S240S|ALOX15B_uc010cnp.2_Silent_p.S46S	NM_001141	NP_001132	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, second type	240	Lipoxygenase.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			ovary(1)	1						TCTTCGCCTCCCAGTTCCTGA	0.607													4	30					0	0	0.009096	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8219387	8219387	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:8219387C>T	uc002glc.2	+	9	1746	c.1625C>T	c.(1624-1626)CCT>CTT	p.P542L	ARHGEF15_uc002gld.2_Missense_Mutation_p.P542L|ARHGEF15_uc010vuw.1_Missense_Mutation_p.P431L	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	542	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CAGAGCCTCCCTAAGTGTGAG	0.687													5	10					0	0	0.000602	0	0
RPL26	6154	broad.mit.edu	37	17	8283225	8283225	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:8283225T>A	uc002glh.1	-	3	294	c.198A>T	c.(196-198)CAA>CAT	p.Q66H		NM_000987	NP_000978	P61254	RL26_HUMAN	ribosomal protein L26	66					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						CTTTGCCAATTTGCTGACCTT	0.373													10	33					0	0	0.013537	0	0
MYH10	4628	broad.mit.edu	37	17	8473084	8473084	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:8473084G>A	uc002gll.2	-	6	776	c.680C>T	c.(679-681)TCA>TTA	p.S227L	MYH10_uc002glm.2_Missense_Mutation_p.S237L|MYH10_uc010cnx.2_Missense_Mutation_p.S236L|MYH10_uc010cny.1_RNA	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	227	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						ATTTCCAAATGATTCCAGAAT	0.348													5	24					0	0	0.000602	0	0
MFSD6L	162387	broad.mit.edu	37	17	8701992	8701992	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:8701992T>A	uc002glp.1	-	1	595	c.447A>T	c.(445-447)GAA>GAT	p.E149D		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	149						integral to membrane				central_nervous_system(1)	1						AGCCAGGCATTTCCACCTCTG	0.582													8	72					0	0	0.004482	0	0
MFSD6L	162387	broad.mit.edu	37	17	8702212	8702212	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:8702212C>T	uc002glp.1	-	1	375	c.227G>A	c.(226-228)AGG>AAG	p.R76K		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	76						integral to membrane				central_nervous_system(1)	1						AAGCGCTCTCCTTTTCCGGTA	0.622													7	39					0	0	0.001984	0	0
WDR16	146845	broad.mit.edu	37	17	9497522	9497522	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:9497522G>A	uc002gly.2	+	4	489	c.420G>A	c.(418-420)TGG>TGA	p.W140*	WDR16_uc002glz.2_Nonsense_Mutation_p.W72*|WDR16_uc010coc.2_Nonsense_Mutation_p.W150*	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	140	WD 2.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TGGTGGTGTGGAGCATAGCCA	0.458													10	65					0	0	0.008291	0	0
GAS7	8522	broad.mit.edu	37	17	9820631	9820631	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:9820631G>A	uc002gmg.1	-	14	1506	c.1345C>T	c.(1345-1347)CGA>TGA	p.R449*	GAS7_uc010vvc.1_Nonsense_Mutation_p.R263*|GAS7_uc002gmh.1_Nonsense_Mutation_p.R309*|GAS7_uc010vvd.1_Nonsense_Mutation_p.R401*|GAS7_uc002gmi.2_Nonsense_Mutation_p.R385*|GAS7_uc002gmj.1_Nonsense_Mutation_p.R389*|GAS7_uc010coh.1_Nonsense_Mutation_p.R389*	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	449					cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						TCCACTTTTCGAAGCAGCTGA	0.582			T	MLL	AML*								7	44					0	0	0.006214	0	0
MYH13	8735	broad.mit.edu	37	17	10215934	10215934	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10215934G>A	uc002gmk.1	-	31	4412	c.4322C>T	c.(4321-4323)ACC>ATC	p.T1441I		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1441	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GGCACAGGCGGTGTGGGAGCG	0.562													6	19					0	0	0.001168	0	0
MYH8	4626	broad.mit.edu	37	17	10300303	10300303	+	Silent	SNP	C	T	T	rs143515663		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10300303C>T	uc002gmm.2	-	31	4274	c.4179G>A	c.(4177-4179)AAG>AAA	p.K1393K	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1393	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CCAACTTTTTCCTGAAAAGTT	0.463									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				4	30					0	0	0.009096	0	0
MYH8	4626	broad.mit.edu	37	17	10322008	10322009	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10322008_10322009GG>AA	uc002gmm.2	-	5	559_560	c.464_465CC>TT	c.(463-465)CCC>CTT	p.P155L	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	155	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						AGAAGATGTGGGGCGGGGCCTC	0.52									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				9	125					0	0	0.004672	0	0
MYH4	4622	broad.mit.edu	37	17	10348210	10348210	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10348210C>T	uc002gmn.2	-	38	5584	c.5473G>A	c.(5473-5475)GAG>AAG	p.E1825K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1825	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CTTTCAAGCTCTCTCACCTGG	0.483													7	77					0	0	0.001984	0	0
MYH4	4622	broad.mit.edu	37	17	10351229	10351229	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10351229C>T	uc002gmn.2	-	34	4982	c.4871G>A	c.(4870-4872)GGA>GAA	p.G1624E	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1624	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						ATTAAGATCTCCCTCCATCTT	0.463													22	123					0	0	0.014323	0	0
MYH4	4622	broad.mit.edu	37	17	10355546	10355546	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10355546G>A	uc002gmn.2	-	27	3561	c.3450C>T	c.(3448-3450)ATC>ATT	p.I1150I	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1150	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GCCTCTCACTGATCTCCTCCA	0.612													21	103					0	0	0.003330	0	0
MYH4	4622	broad.mit.edu	37	17	10363379	10363379	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10363379C>T	uc002gmn.2	-	14	1417	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	436	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AACATCTTCTCGTAGATGGCT	0.483													10	94					0	0	0.008291	0	0
MYH4	4622	broad.mit.edu	37	17	10366925	10366926	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10366925_10366926GG>AA	uc002gmn.2	-	8	794_795	c.683_684CC>TT	c.(682-684)CCC>CTT	p.P228L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	228	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CTTCCAGTAGGGGGTTAGCACT	0.416													10	43					0	0	0.004672	0	0
MYH4	4622	broad.mit.edu	37	17	10369992	10369992	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10369992C>T	uc002gmn.2	-	3	182	c.71G>A	c.(70-72)CGA>CAA	p.R24Q	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	24	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AGCTTCAATTCGCTCCTTTTC	0.498													9	93					0	0	0.004482	0	0
MYH1	4619	broad.mit.edu	37	17	10395847	10395847	+	Silent	SNP	C	T	T	rs138386754		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10395847C>T	uc002gmo.2	-	40	5800	c.5706G>A	c.(5704-5706)AGG>AGA	p.R1902R	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1902	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.R1902R(1)		ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CGTGCTGGATCCTGCGGAATT	0.488													9	55					0	0	0.006214	0	0
MYH1	4619	broad.mit.edu	37	17	10399641	10399641	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10399641C>T	uc002gmo.2	-	34	4976	c.4882G>A	c.(4882-4884)GAA>AAA	p.E1628K	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1628	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						ATTTCCATTTCATTGAGGTCT	0.498													11	88					0	0	0.008291	0	0
MYH1	4619	broad.mit.edu	37	17	10400471	10400471	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10400471C>T	uc002gmo.2	-	33	4665	c.4571G>A	c.(4570-4572)GGA>GAA	p.G1524E	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1524	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GATGCGCTTTCCTCCTTCTGC	0.368													4	30					0	0	0.000602	0	0
MYH2	4620	broad.mit.edu	37	17	10432229	10432229	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10432229C>T	uc010coi.2	-	27	3650	c.3522G>A	c.(3520-3522)GAG>GAA	p.E1174E	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.E1174E|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1174	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GGAACTCAGCCTCCCGCTTCT	0.607													12	93					0	0	0.003163	0	0
MYH2	4620	broad.mit.edu	37	17	10433037	10433037	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10433037C>T	uc010coi.2	-	24	3089	c.2961G>A	c.(2959-2961)GAG>GAA	p.E987E	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.E987E|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	987	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GACCTGCCATCTCTTCTGTGA	0.493													18	121					0	0	0.014323	0	0
MYH2	4620	broad.mit.edu	37	17	10444001	10444001	+	Silent	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:10444001A>T	uc010coi.2	-	11	1046	c.918T>A	c.(916-918)ATT>ATA	p.I306I	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.I306I|MYH2_uc010coj.2_Silent_p.I306I	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	306	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GGTTCGTGGTAATCAGAAGCA	0.378													5	46					0	0	0.000602	0	0
DNAH9	1770	broad.mit.edu	37	17	11593689	11593689	+	Missense_Mutation	SNP	G	A	A	rs139715944		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:11593689G>A	uc002gne.2	+	20	4618	c.4550G>A	c.(4549-4551)CGA>CAA	p.R1517Q	DNAH9_uc010coo.2_Missense_Mutation_p.R811Q	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1517	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAAGTGCAGCGAACATGGACT	0.483													10	50					0	0	0.008291	0	0
DNAH9	1770	broad.mit.edu	37	17	11666774	11666774	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:11666774C>T	uc002gne.2	+	36	7081	c.7013C>T	c.(7012-7014)CCC>CTC	p.P2338L	DNAH9_uc010coo.2_Missense_Mutation_p.P1632L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2338					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AAGATCATTCCCATCCCAGAG	0.498													11	95					0	0	0.001855	0	0
DNAH9	1770	broad.mit.edu	37	17	11666784	11666784	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:11666784G>A	uc002gne.2	+	36	7091	c.7023G>A	c.(7021-7023)GAG>GAA	p.E2341E	DNAH9_uc010coo.2_Silent_p.E1635E	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2341					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCATCCCAGAGCAGAGCATGG	0.483													12	100					0	0	0.004007	0	0
DNAH9	1770	broad.mit.edu	37	17	11671843	11671843	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:11671843G>A	uc002gne.2	+	37	7312	c.7244G>A	c.(7243-7245)GGA>GAA	p.G2415E	DNAH9_uc010coo.2_Missense_Mutation_p.G1709E	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2415					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCTTCCCAAGGAACCATCTTT	0.502													15	41					0	0	0.002450	0	0
DNAH9	1770	broad.mit.edu	37	17	11757612	11757612	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:11757612C>A	uc002gne.2	+	50	9868	c.9800C>A	c.(9799-9801)TCC>TAC	p.S3267Y	DNAH9_uc010coo.2_Missense_Mutation_p.S2561Y	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3267	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGCCTCTGCTCCTGGGTCATC	0.547													7	136					0.00307968	0.00331323	0.003080	1	0
DNAH9	1770	broad.mit.edu	37	17	11872808	11872808	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:11872808G>A	uc002gne.2	+	69	13493	c.13425G>A	c.(13423-13425)TGG>TGA	p.W4475*	DNAH9_uc010coo.2_Nonsense_Mutation_p.W3693*|DNAH9_uc002gnf.2_Nonsense_Mutation_p.W787*	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	4475					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CATCCAAGTGGGTTCTGGCTG	0.527													3	19					0	0	0.009096	0	0
MYOCD	93649	broad.mit.edu	37	17	12647610	12647610	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:12647610G>A	uc002gnn.2	+	8	1127	c.828G>A	c.(826-828)GAG>GAA	p.E276E	MYOCD_uc002gno.2_Silent_p.E276E|MYOCD_uc002gnp.1_Silent_p.E180E|MYOCD_uc002gnq.2_5'UTR	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	276					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGAAGGCAGAGAAGTCCCCTC	0.493													4	31					0	0	0.000602	0	0
MYOCD	93649	broad.mit.edu	37	17	12656434	12656434	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:12656434G>A	uc002gnn.2	+	10	2128	c.1829G>A	c.(1828-1830)GGA>GAA	p.G610E	MYOCD_uc002gno.2_Missense_Mutation_p.G610E|MYOCD_uc002gnp.1_Missense_Mutation_p.G514E|MYOCD_uc002gnq.2_Missense_Mutation_p.G329E	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	610					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding	p.G610R(1)		central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CAGCCTCTTGGAAATGCTCAT	0.522													8	92					0	0	0.006214	0	0
RICH2	9912	broad.mit.edu	37	17	12823142	12823142	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:12823142G>A	uc002gnr.3	+	6	785	c.458G>A	c.(457-459)CGA>CAA	p.R153Q	RICH2_uc010vvk.1_Missense_Mutation_p.R153Q|RICH2_uc010vvl.1_Missense_Mutation_p.R153Q|RICH2_uc002gns.3_5'UTR|RICH2_uc010vvm.1_Missense_Mutation_p.R153Q|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	153	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						GATTCCTCACGAACCAGGTAG	0.383													5	12					0	0	0.000602	0	0
ELAC2	60528	broad.mit.edu	37	17	12901800	12901800	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:12901800G>A	uc002gnz.3	-	16	1544	c.1449C>T	c.(1447-1449)ATC>ATT	p.I483I	ELAC2_uc002gnu.3_5'UTR|ELAC2_uc002gnv.3_Silent_p.I111I|ELAC2_uc002gnw.3_Silent_p.I141I|ELAC2_uc002gnx.3_Silent_p.I243I|ELAC2_uc010vvo.1_Silent_p.I281I|ELAC2_uc010vvp.1_Silent_p.I464I|ELAC2_uc010vvq.1_Silent_p.I482I|ELAC2_uc010vvr.1_Silent_p.I443I	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	elaC homolog 2 isoform 1	483					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding				0						CAAGGAAGATGATTTCTGGGT	0.448									Hereditary_Prostate_Cancer				7	30					0	0	0.004482	0	0
NCOR1	9611	broad.mit.edu	37	17	15989718	15989718	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:15989718G>A	uc002gpo.2	-	23	3295	c.3055C>T	c.(3055-3057)CCT>TCT	p.P1019S	NCOR1_uc002gpn.2_Missense_Mutation_p.P1035S|NCOR1_uc002gpp.1_Missense_Mutation_p.P926S|NCOR1_uc002gpq.1_Missense_Mutation_p.P111S	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1019	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ACGCCTTCAGGGAGATTAGTT	0.443													6	50					0	0	0.001168	0	0
ZNF287	57336	broad.mit.edu	37	17	16455190	16455190	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:16455190C>T	uc002gqi.2	-	6	2719	c.2266G>A	c.(2266-2268)GGT>AGT	p.G756S		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	749					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TGTTTGGCACCTGTATGAACA	0.378													9	90					0	0	0.006214	0	0
MED9	55090	broad.mit.edu	37	17	17394689	17394690	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:17394689_17394690CC>TT	uc002grh.1	+	2	377_378	c.321_322CC>TT	c.(319-324)ATCCAC>ATTTAC	p.H108Y		NM_018019	NP_060489	Q9NWA0	MED9_HUMAN	mediator complex subunit 9	108					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		protein binding				0						TGCCCGGCATCCACCTGAGCCC	0.579													6	46					0	0	0.004672	0	0
MYO15A	51168	broad.mit.edu	37	17	18052889	18052889	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:18052889G>A	uc010vxh.1	+	34	7545	c.7207G>A	c.(7207-7209)GAT>AAT	p.D2403N		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2403	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GTCCTACGGGGATGCGGTAGG	0.577													6	35					0	0	0.003080	0	0
SMCR8	140775	broad.mit.edu	37	17	18219178	18219178	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:18219178C>T	uc002gsy.3	+	1	585	c.75C>T	c.(73-75)GCC>GCT	p.A25A		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	25										central_nervous_system(1)	1						ATGAGCCGGCCCTGCCTGAGG	0.522													5	45					0	0	0.000602	0	0
FBXW10	10517	broad.mit.edu	37	17	18675803	18675803	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:18675803G>A	uc002guk.2	+	12	2317	c.2085G>A	c.(2083-2085)ACG>ACA	p.T695T	FBXW10_uc002guj.2_Silent_p.T695T|FBXW10_uc002gul.2_Silent_p.T724T|FBXW10_uc010cqh.1_Silent_p.T642T	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	695	Potential.									ovary(1)	1						Tggaaaaaacgaaacaaaaga	0.323													21	107					0	0	0.012319	0	0
SLC47A1	55244	broad.mit.edu	37	17	19470507	19470507	+	Silent	SNP	C	T	T	rs34576017	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:19470507C>T	uc002gvy.1	+	14	1361	c.1275C>T	c.(1273-1275)ATC>ATT	p.I425I	SLC47A1_uc002gvx.2_Silent_p.I425I|SLC47A1_uc010vyz.1_Silent_p.I402I|SLC47A1_uc010cqp.1_Intron|SLC47A1_uc010cqq.1_Silent_p.I230I|SLC47A1_uc010vza.1_Silent_p.I137I|SLC47A1_uc010vzb.1_Silent_p.I159I|SLC47A1_uc010vzc.1_Silent_p.I97I	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	425	Helical; (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					CCATCGGGATCGCGCTGATGT	0.552													11	85					0	0	0.008291	0	0
CCDC144C	348254	broad.mit.edu	37	17	20242862	20242863	+	RNA	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:20242862_20242863CC>TT	uc010cqy.1	+	5		c.951_952CC>TT				NR_023380				Homo sapiens cDNA FLJ59693 complete cds, moderately similar to Ankyrin repeat domain-containing protein 26.												0						TCCAGTACTTCCTCATGTGCAA	0.371													6	53					0	0	0.004672	0	0
LGALS9	3965	broad.mit.edu	37	17	25967724	25967724	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:25967724G>A	uc002gzp.2	+	3	376	c.258G>A	c.(256-258)GAG>GAA	p.E86E	LGALS9_uc002gzq.2_Silent_p.E86E|LGALS9_uc002gzr.2_Silent_p.E29E|LGALS9_uc010waa.1_Silent_p.E29E|LGALS9_uc002gzs.2_Silent_p.E86E	NM_009587	NP_033665	O00182	LEG9_HUMAN	galectin-9 isoform long	86	Galectin 1.|Beta-galactoside binding 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity				0	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		GGCCCGAGGAGAGGAAGACAC	0.552													13	99					0	0	0.007413	0	0
SLC13A2	9058	broad.mit.edu	37	17	26816316	26816316	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:26816316C>T	uc002hbh.2	+	2	254	c.187C>T	c.(187-189)CCC>TCC	p.P63S	SLC13A2_uc010wal.1_Intron|SLC13A2_uc010wam.1_Missense_Mutation_p.P19S|SLC13A2_uc010wan.1_Missense_Mutation_p.P63S|SLC13A2_uc010wao.1_Intron|SLC13A2_uc002hbi.2_5'UTR	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	63	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	TGCCCTCTTCCCCTTAATCCT	0.622													9	27					0	0	0.006214	0	0
MYO18A	399687	broad.mit.edu	37	17	27419372	27419372	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:27419372C>T	uc002hdt.1	-	34	5334	c.5176G>A	c.(5176-5178)GCC>ACC	p.A1726T	MYO18A_uc010wbc.1_Missense_Mutation_p.A1259T|MYO18A_uc002hds.2_Missense_Mutation_p.A1268T|MYO18A_uc010csa.1_Missense_Mutation_p.A1689T|MYO18A_uc002hdu.1_Missense_Mutation_p.A1726T	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1726	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GCTGTCTTGGCTTTGGCGATG	0.612													5	20					0	0	0.001168	0	0
TAOK1	57551	broad.mit.edu	37	17	27844579	27844579	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:27844579C>T	uc002hdz.1	+	16	2007	c.1813C>T	c.(1813-1815)CGA>TGA	p.R605*	TAOK1_uc010wbe.1_Intron|TAOK1_uc010wbf.1_Nonsense_Mutation_p.R605*	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	605	Potential.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			TAACCTTCTTCGACGTCAAAG	0.443													9	97					0	0	0.006214	0	0
SSH2	85464	broad.mit.edu	37	17	27958624	27958625	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:27958624_27958625GG>AA	uc002heo.1	-	15	3506_3507	c.3506_3507CC>TT	c.(3505-3507)TCC>TTT	p.S1169F	SSH2_uc010wbh.1_Missense_Mutation_p.S1196F	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	1169					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						CACTGCCACTGGAGAGAGGGCT	0.505													9	47					0	0	0.004672	0	0
EFCAB5	374786	broad.mit.edu	37	17	28378158	28378158	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:28378158G>A	uc002het.2	+	9	1415	c.1223G>A	c.(1222-1224)AGG>AAG	p.R408K	EFCAB5_uc010wbi.1_Missense_Mutation_p.R151K|EFCAB5_uc010wbj.1_Missense_Mutation_p.R352K|EFCAB5_uc010wbk.1_Missense_Mutation_p.R65K|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Missense_Mutation_p.R287K|EFCAB5_uc010csf.2_Missense_Mutation_p.R287K	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	408							calcium ion binding			ovary(1)|skin(1)	2						GATCGGCAGAGGACATTGGCC	0.418													6	49					0	0	0.006214	0	0
EFCAB5	374786	broad.mit.edu	37	17	28384850	28384850	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:28384850C>T	uc002het.2	+	13	2714	c.2522C>T	c.(2521-2523)TCC>TTC	p.S841F	EFCAB5_uc010wbj.1_Missense_Mutation_p.S785F|EFCAB5_uc010wbk.1_Missense_Mutation_p.S498F|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Intron|EFCAB5_uc010csf.2_Missense_Mutation_p.S720F	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	841							calcium ion binding			ovary(1)|skin(1)	2						ACTCTCACCTCCTTTTTTAAG	0.413													18	69					0	0	0.010504	0	0
NF1	4763	broad.mit.edu	37	17	29562641	29562641	+	Nonsense_Mutation	SNP	C	T	T	rs137854562		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:29562641C>T	uc002hgg.2	+	28	4054	c.3721C>T	c.(3721-3723)CGA>TGA	p.R1241*	NF1_uc002hgh.2_Nonsense_Mutation_p.R1241*|NF1_uc010csn.1_Nonsense_Mutation_p.R1101*|NF1_uc002hgi.1_Nonsense_Mutation_p.R274*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1241	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)|p.R1241*(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGAACTAGCTCGAGTTCTGGT	0.388			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			26	131					0	0	0.006320	0	0
NF1	4763	broad.mit.edu	37	17	29684035	29684035	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:29684035C>T	uc002hgg.2	+	53	8129	c.7796C>T	c.(7795-7797)TCT>TTT	p.S2599F	NF1_uc002hgh.2_Missense_Mutation_p.S2578F|NF1_uc010cso.2_Missense_Mutation_p.S787F|NF1_uc010wbt.1_Missense_Mutation_p.S77F|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2599					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GTTTCAGTGTCTGAATCAAAT	0.423			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			12	92					0	0	0.001855	0	0
MYO1D	4642	broad.mit.edu	37	17	30932226	30932226	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:30932226G>A	uc002hho.1	-	21	2755	c.2743C>T	c.(2743-2745)CAA>TAA	p.Q915*	MYO1D_uc002hhp.1_Nonsense_Mutation_p.Q915*	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	915						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			ACTACAAGTTGGTCCTTTCCA	0.393													5	23					0	0	0.000602	0	0
TMEM132E	124842	broad.mit.edu	37	17	32964615	32964615	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:32964615C>T	uc002hif.2	+	10	2647	c.2319C>T	c.(2317-2319)GTC>GTT	p.V773V		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	773	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCAGCCCCGTCGTGCCACCCA	0.751													4	15					0	0	0.009096	0	0
SLFN12	55106	broad.mit.edu	37	17	33749180	33749180	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:33749180G>A	uc002hji.3	-	2	1245	c.868C>T	c.(868-870)CTT>TTT	p.L290F	SLFN12_uc002hjj.3_Missense_Mutation_p.L290F|SLFN12_uc010cts.2_Missense_Mutation_p.L290F	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	290							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TATACTCCAAGGAATTTGCAT	0.418													4	35					0	0	0.000602	0	0
AP2B1	163	broad.mit.edu	37	17	33951501	33951501	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:33951501T>A	uc002hjr.2	+	6	800	c.611T>A	c.(610-612)ATT>AAT	p.I204N	AP2B1_uc002hjq.2_Missense_Mutation_p.I204N|AP2B1_uc010wci.1_Missense_Mutation_p.I166N|AP2B1_uc002hjs.2_Missense_Mutation_p.I147N|AP2B1_uc002hjt.2_Missense_Mutation_p.I204N|AP2B1_uc010ctv.2_Missense_Mutation_p.I204N|AP2B1_uc010wcj.1_5'UTR	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	204					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CCACAGAACATTAATAAGCTG	0.473													19	71					0	0	0.010504	0	0
TADA2A	6871	broad.mit.edu	37	17	35783643	35783643	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:35783643C>T	uc002hnt.2	+	3	217	c.60C>T	c.(58-60)TGC>TGT	p.C20C	TADA2A_uc002hnu.1_Silent_p.C20C|TADA2A_uc002hnv.2_Silent_p.C20C|TADA2A_uc010wdd.1_Silent_p.C20C|TADA2A_uc002hnw.2_5'UTR	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	20	Cys-rich.				histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						GCCGAGGCTGCTCCTCCTACC	0.463													13	105					0	0	0.004007	0	0
GPR179	440435	broad.mit.edu	37	17	36485159	36485159	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:36485159C>T	uc002hpz.2	-	11	4314	c.4293G>A	c.(4291-4293)GAG>GAA	p.E1431E		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1431	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AATCTGTACTCTCCCATGGAC	0.517													13	45					0	0	0.013537	0	0
GPR179	440435	broad.mit.edu	37	17	36485191	36485191	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:36485191C>T	uc002hpz.2	-	11	4282	c.4261G>A	c.(4261-4263)GGA>AGA	p.G1421R		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1421	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AAGTCTCCTCCCGGTTTCTGT	0.537													11	54					0	0	0.013537	0	0
SOCS7	30837	broad.mit.edu	37	17	36520712	36520712	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:36520712C>T	uc002hqa.2	+	3	1054	c.931C>T	c.(931-933)CCT>TCT	p.P311S	SOCS7_uc010cvl.2_Missense_Mutation_p.P311S|SOCS7_uc002hqb.2_RNA	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	311	Mediates interaction with SORBS3.|Poly-Pro.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					TCCCCCTCCTCCTCCGAGAAG	0.567													10	60					0	0	0.010729	0	0
Unknown	0	broad.mit.edu	37	17	37188446	37188446	+	RNA	SNP	G	A	A	rs148983654		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:37188446G>A	uc002hrd.1	+	1		c.2288G>A								Homo sapiens cDNA FLJ43826 fis, clone TESTI4002703.																		AAACCTGACTGAAGTCACAGG	0.478													15	95					0	0	0.004007	0	0
ERBB2	2064	broad.mit.edu	37	17	37866370	37866370	+	Silent	SNP	C	T	T	rs140636713		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:37866370C>T	uc002hso.2	+	6	913	c.675C>T	c.(673-675)GCC>GCT	p.A225A	ERBB2_uc002hsm.2_Silent_p.A195A|ERBB2_uc010cwa.2_Silent_p.A210A|ERBB2_uc002hsp.2_Silent_p.A28A|ERBB2_uc010cwb.2_Silent_p.A225A|ERBB2_uc010wek.1_Intron|ERBB2_uc002hsl.2_Silent_p.A195A|ERBB2_uc002hsn.1_Silent_p.A225A	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	225	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GTGGCTGTGCCCGCTGCAAGG	0.647		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			4	63					0	0	0.009096	0	0
GRB7	2886	broad.mit.edu	37	17	37902204	37902204	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:37902204T>C	uc002hsr.2	+	13	1559	c.1309T>C	c.(1309-1311)TCC>CCC	p.S437P	GRB7_uc002hss.2_Missense_Mutation_p.S437P|GRB7_uc010cwc.2_Missense_Mutation_p.S437P|GRB7_uc002hst.2_Intron	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	437	SH2.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CGGGCGCATTTCCCGTGAGGA	0.627													11	100					0	0	0.003163	0	0
KRT12	3859	broad.mit.edu	37	17	39019844	39019844	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:39019844C>T	uc002hvk.2	-	5	1012	c.988G>A	c.(988-990)GAG>AAG	p.E330K		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	330	Rod.|Coil 2.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GTGCTAATCTCCTTACGGAGC	0.577													4	28					0	0	0.000602	0	0
KRT33A	3883	broad.mit.edu	37	17	39503171	39503171	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:39503171G>A	uc002hwk.1	-	5	838	c.801C>T	c.(799-801)TCC>TCT	p.S267S		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	267	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				CCGCCTGGTAGGACTGCAGCT	0.602													11	40					0	0	0.002450	0	0
KRT31	3881	broad.mit.edu	37	17	39551875	39551875	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:39551875C>T	uc002hwn.2	-	4	642	c.589G>A	c.(589-591)GAG>AAG	p.E197K	KRT31_uc010cxn.2_Missense_Mutation_p.E197K	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	197	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				GTATTGACCTCCTATGGATGC	0.493													7	18					0	0	0.001984	0	0
KRT37	8688	broad.mit.edu	37	17	39577662	39577662	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:39577662C>T	uc002hwp.1	-	6	1245	c.1198G>A	c.(1198-1200)GAG>AAG	p.E400K	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	400	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GTGGCAATCTCGTTCTCCAAC	0.557													4	34					0	0	0.000602	0	0
KRT37	8688	broad.mit.edu	37	17	39580692	39580692	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:39580692G>A	uc002hwp.1	-	1	131	c.84C>T	c.(82-84)ATC>ATT	p.I28I	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	28	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				ACCCAACATCGATAGGAGAGA	0.592													7	50					0	0	0.001984	0	0
KRT38	8687	broad.mit.edu	37	17	39594533	39594533	+	Silent	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:39594533G>C	uc002hwq.1	-	6	1476	c.1053C>G	c.(1051-1053)GCC>GCG	p.A351A		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	351	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				AGCGGTCCTCGGCTTCACACA	0.552													7	26					0	0	0.001984	0	0
KRT17	3872	broad.mit.edu	37	17	39777961	39777961	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:39777961C>T	uc002hxh.2	-	4	839	c.718G>A	c.(718-720)GAG>AAG	p.E240K	JUP_uc010wfs.1_Intron	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	240	Linker 12.|Rod.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				GCGTCCATCTCCACATTGATC	0.577									Steatocystoma_Multiplex				9	32					0	0	0.010729	0	0
GHDC	84514	broad.mit.edu	37	17	40344388	40344388	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:40344388G>A	uc002hzd.2	-	4	1244	c.760C>T	c.(760-762)CGG>TGG	p.R254W	GHDC_uc002hzg.1_Missense_Mutation_p.R254W|GHDC_uc010wgg.1_Missense_Mutation_p.R215W|GHDC_uc002hze.3_Missense_Mutation_p.R254W|GHDC_uc002hzf.3_Missense_Mutation_p.R254W|GHDC_uc010cxz.2_RNA	NM_032484	NP_115873	Q8N2G8	GHDC_HUMAN	LGP1 homolog isoform 1	254						endoplasmic reticulum|nuclear envelope					0		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GGCCAGAGCCGAAGGGCCAGT	0.687													7	69					0	0	0.001984	0	0
DHX8	1659	broad.mit.edu	37	17	41584468	41584468	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:41584468C>T	uc002idu.1	+	13	1899	c.1826C>T	c.(1825-1827)TCC>TTC	p.S609F	DHX8_uc010wif.1_Missense_Mutation_p.S518F|DHX8_uc010wig.1_Missense_Mutation_p.S609F	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	609	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		GGCTACACTTCCAGGGGCAAG	0.532													16	69					0	0	0.008871	0	0
ETV4	2118	broad.mit.edu	37	17	41610701	41610701	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:41610701G>A	uc002idw.2	-	7	527	c.399C>T	c.(397-399)CCC>CCT	p.P133P	ETV4_uc002idv.2_5'Flank|ETV4_uc010wih.1_Intron|ETV4_uc010czh.2_Silent_p.P132P|ETV4_uc010wii.1_Silent_p.P94P|ETV4_uc002idx.2_Silent_p.P133P|ETV4_uc010wij.1_Silent_p.P94P|ETV4_uc002idy.1_Silent_p.P94P	NM_001986	NP_001977	P43268	ETV4_HUMAN	ets variant gene 4 (E1A enhancer binding	133					positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/ETV4(6)	bone(4)|soft_tissue(2)|ovary(1)	7		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)		CGATTTGTCTGGGGGGGTCAT	0.577			T	EWSR1|TMPRSS2|DDX5|KLK2|CANT1	Ewing sarcoma|Prostate carcinoma								4	31					0	0	0.000602	0	0
MAP3K14	9020	broad.mit.edu	37	17	43348577	43348577	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:43348577G>A	uc002iiw.1	-	11	1778	c.1669C>T	c.(1669-1671)CCT>TCT	p.P557S	MAP3K14_uc002iiu.1_Missense_Mutation_p.P87S|MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_Missense_Mutation_p.P141S	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	557	Interaction with ZFP91.|Protein kinase.				cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						TCTGTGCCAGGGATGTAGTCC	0.582													6	39					0	0	0.001984	0	0
KIAA1267	284058	broad.mit.edu	37	17	44109634	44109635	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:44109634_44109635GG>AA	uc002ikb.2	-	13	2953_2954	c.2868_2869CC>TT	c.(2866-2871)ACCCCC>ACTTCC	p.P957S	KIAA1267_uc002ikc.2_Missense_Mutation_p.P957S|KIAA1267_uc002ikd.2_Missense_Mutation_p.P957S|KIAA1267_uc010dav.2_Missense_Mutation_p.P956S|KIAA1267_uc010wkb.1_Missense_Mutation_p.P288S|KIAA1267_uc010wkc.1_Missense_Mutation_p.P225S	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	957						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				CCCAGCTGGGGGGTTGTCCGGC	0.564													7	77					0	0	0.004672	0	0
HOXB8	3218	broad.mit.edu	37	17	46690569	46690569	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:46690569T>G	uc002inw.2	-	2	962	c.727A>C	c.(727-729)AAG>CAG	p.K243Q	HOXB7_uc002inv.2_5'Flank	NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	243						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GAAGCCTACTTCTTGTCGCCC	0.473													6	70					0	0	0.001168	0	0
ZNF652	22834	broad.mit.edu	37	17	47389359	47389359	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:47389359G>A	uc002iov.3	-	4	1558	c.1094C>T	c.(1093-1095)TCA>TTA	p.S365L	ZNF652_uc002iow.2_Missense_Mutation_p.S365L|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	365	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			GCGTTTGAATGATTTTCCACA	0.448													9	66					0	0	0.010729	0	0
NXPH3	11248	broad.mit.edu	37	17	47656183	47656183	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:47656183G>A	uc002ipa.2	+	2	564	c.280G>A	c.(280-282)GCC>ACC	p.A94T	NXPH3_uc010wlw.1_Missense_Mutation_p.A94T	NM_007225	NP_009156	O95157	NXPH3_HUMAN	neurexophilin 3 precursor	94	III.				neuropeptide signaling pathway	extracellular region				pancreas(1)|skin(1)	2	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					CCCACCCTCAGCCAAGGTGAA	0.617													4	27					0	0	0.009096	0	0
MYST2	11143	broad.mit.edu	37	17	47900574	47900574	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:47900574C>T	uc002ipm.2	+	12	1523	c.1397C>T	c.(1396-1398)TCA>TTA	p.S466L	MYST2_uc010wma.1_Missense_Mutation_p.S327L|MYST2_uc010wmb.1_Missense_Mutation_p.S356L|MYST2_uc010wmc.1_Missense_Mutation_p.S297L|MYST2_uc010wmd.1_Missense_Mutation_p.S310L|MYST2_uc010wme.1_Missense_Mutation_p.S280L|MYST2_uc010wmf.1_Missense_Mutation_p.S131L|MYST2_uc010wmg.1_Missense_Mutation_p.S21L	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	466					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GAAAAGAATTCATTCCTCAAC	0.388													6	46					0	0	0.001984	0	0
ITGA3	3675	broad.mit.edu	37	17	48148254	48148254	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:48148254T>C	uc010dbl.2	+	5	1175	c.711T>C	c.(709-711)TAT>TAC	p.Y237Y	ITGA3_uc010dbm.2_Silent_p.Y237Y	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	237	FG-GAP 4.|Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						TATCTGAGTATAGTTACAAGG	0.502													23	228					0	0	0.003954	0	0
ITGA3	3675	broad.mit.edu	37	17	48155608	48155608	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:48155608A>T	uc010dbl.2	+	18	2721	c.2257A>T	c.(2257-2259)ACT>TCT	p.T753S	ITGA3_uc010dbm.2_Missense_Mutation_p.T753S	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	753	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						CATGATCCTCACTCTGCTGGT	0.582													9	69					0	0	0.001855	0	0
COL1A1	1277	broad.mit.edu	37	17	48271376	48271376	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:48271376G>A	uc002iqm.2	-	25	1821	c.1695C>T	c.(1693-1695)CCC>CCT	p.P565P		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	565	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	CTGGGGGTCCGGGGCGACCAT	0.612			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						6	59					0	0	0.001168	0	0
COL1A1	1277	broad.mit.edu	37	17	48271742	48271742	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:48271742G>A	uc002iqm.2	-	23	1708	c.1582C>T	c.(1582-1584)CGT>TGT	p.R528C		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	528	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	TCACCGGGACGACCAGCTTCA	0.637			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						11	53					0	0	0.008291	0	0
ANKRD40	91369	broad.mit.edu	37	17	48773374	48773374	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:48773374G>A	uc002iso.2	-	5	1346	c.1091C>T	c.(1090-1092)TCA>TTA	p.S364L		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	364											0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			AGTCAGTTTTGAAGCTCTCCT	0.428													13	54					0	0	0.002450	0	0
KIF2B	84643	broad.mit.edu	37	17	51900847	51900847	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:51900847G>A	uc002iua.2	+	1	609	c.453G>A	c.(451-453)TGG>TGA	p.W151*	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	151	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CCTGCCTCTGGGAAATCCAGA	0.562													6	69					0	0	0.001168	0	0
TOM1L1	10040	broad.mit.edu	37	17	52990072	52990072	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:52990072C>T	uc002iud.2	+	4	443	c.268C>T	c.(268-270)CTG>TTG	p.L90L	TOM1L1_uc002iub.2_Silent_p.L55L|TOM1L1_uc002iuc.2_Silent_p.L90L|TOM1L1_uc010dca.1_Silent_p.L90L|TOM1L1_uc010wnb.1_Silent_p.L83L|TOM1L1_uc010wnc.1_Silent_p.L13L|TOM1L1_uc010dbz.2_Silent_p.L13L|TOM1L1_uc010wnd.1_Silent_p.L13L|TOM1L1_uc010dcb.1_5'Flank	NM_005486	NP_005477	O75674	TM1L1_HUMAN	target of myb1-like 1	90	VHS.				intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			ovary(1)	1						TTTCCAGTCTCTGATTGTGAA	0.323													8	47					0	0	0.010729	0	0
TOM1L1	10040	broad.mit.edu	37	17	53014581	53014582	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:53014581_53014582GG>AA	uc002iud.2	+	10	1202_1203	c.1027_1028GG>AA	c.(1027-1029)GGC>AAC	p.G343N	TOM1L1_uc002iuc.2_Missense_Mutation_p.G343N|TOM1L1_uc010dca.1_Missense_Mutation_p.G343N|TOM1L1_uc010wnb.1_Missense_Mutation_p.G336N|TOM1L1_uc010wnc.1_Missense_Mutation_p.G266N|TOM1L1_uc010dbz.2_Missense_Mutation_p.G266N|TOM1L1_uc010wnd.1_Missense_Mutation_p.G231N|TOM1L1_uc010dcb.1_RNA	NM_005486	NP_005477	O75674	TM1L1_HUMAN	target of myb1-like 1	343					intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			ovary(1)	1						TCAACTTTCAGGCTTAAGTAAA	0.45													6	70					0	0	0.004672	0	0
VEZF1	7716	broad.mit.edu	37	17	56051965	56051966	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:56051965_56051966GG>AA	uc002ivf.1	-	6	1577_1578	c.1434_1435CC>TT	c.(1432-1437)CACCCT>CATTCT	p.P479S		NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	479	4.|4 X 7 AA repeats of P-[LV]-T-[IL]-T-[ST]- P.				cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ATGGTGACAGGGTGTGCTATAT	0.495													6	53					0	0	0.004672	0	0
BZRAP1	9256	broad.mit.edu	37	17	56382511	56382511	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:56382511C>T	uc002ivx.3	-	30	6326	c.5455G>A	c.(5455-5457)GGC>AGC	p.G1819S	BZRAP1_uc002ivv.2_Missense_Mutation_p.G49S|BZRAP1_uc002ivw.2_Missense_Mutation_p.G51S|BZRAP1_uc010dcs.2_Missense_Mutation_p.G1759S|BZRAP1_uc010wnt.1_Missense_Mutation_p.G1810S	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1819	SH3 3.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGAACCAGGCCCCTTTGTCCA	0.622													4	34					0	0	0.000602	0	0
BZRAP1	9256	broad.mit.edu	37	17	56382513	56382513	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:56382513C>T	uc002ivx.3	-	30	6324	c.5453G>A	c.(5452-5454)AGG>AAG	p.R1818K	BZRAP1_uc002ivv.2_Missense_Mutation_p.R48K|BZRAP1_uc002ivw.2_Missense_Mutation_p.R50K|BZRAP1_uc010dcs.2_Missense_Mutation_p.R1758K|BZRAP1_uc010wnt.1_Missense_Mutation_p.R1809K	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1818	SH3 3.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AACCAGGCCCCTTTGTCCATT	0.622													4	31					0	0	0.000602	0	0
RNF43	54894	broad.mit.edu	37	17	56435504	56435504	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:56435504A>G	uc002iwf.2	-	8	3589	c.1633T>C	c.(1633-1635)TCC>CCC	p.S545P	RNF43_uc010wnv.1_Missense_Mutation_p.S504P|RNF43_uc002iwh.3_Missense_Mutation_p.S545P|RNF43_uc002iwg.3_Missense_Mutation_p.S545P|RNF43_uc010dcw.2_Missense_Mutation_p.S418P	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	545	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACATGGCTGGAAACCTGGGTT	0.622													9	57					0	0	0.006214	0	0
TEX14	56155	broad.mit.edu	37	17	56693624	56693624	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:56693624G>A	uc010dcz.1	-	7	815	c.697C>T	c.(697-699)CTT>TTT	p.L233F	TEX14_uc002iwr.1_Missense_Mutation_p.L227F|TEX14_uc002iws.1_Missense_Mutation_p.L227F|TEX14_uc010dda.1_Missense_Mutation_p.L7F	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	233	ATP (By similarity).|Protein kinase.					cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ATGACCGGAAGAGATCCTAGA	0.488													17	50					0	0	0.007413	0	0
TEX14	56155	broad.mit.edu	37	17	56694920	56694920	+	Silent	SNP	G	A	A	rs62081268		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:56694920G>A	uc010dcz.1	-	6	733	c.615C>T	c.(613-615)ATC>ATT	p.I205I	TEX14_uc002iwr.1_Silent_p.I205I|TEX14_uc002iws.1_Silent_p.I205I|TEX14_uc010dda.1_Intron	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	205						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CAAAGCTGTAGATATTTTGAG	0.433													10	104					0	0	0.001855	0	0
TEX14	56155	broad.mit.edu	37	17	56699130	56699130	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:56699130C>G	uc010dcz.1	-	5	553	c.435G>C	c.(433-435)CAG>CAC	p.Q145H	TEX14_uc002iwr.1_Missense_Mutation_p.Q145H|TEX14_uc002iws.1_Missense_Mutation_p.Q145H|TEX14_uc010dda.1_5'UTR	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	145						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGGCACAGCGCTGCATGAACT	0.552													14	32					0	0	0.001855	0	0
HEATR6	63897	broad.mit.edu	37	17	58144948	58144948	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:58144948G>A	uc002iyk.1	-	8	1102	c.1085C>T	c.(1084-1086)TCC>TTC	p.S362F	HEATR6_uc010ddk.1_5'Flank|HEATR6_uc010wos.1_Missense_Mutation_p.S194F	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	362				SS -> FF (in Ref. 1; BAB15229).			binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			ACCCAGGGAGGAGGGACACCA	0.527													8	21					0	0	0.003080	0	0
BRIP1	83990	broad.mit.edu	37	17	59763235	59763235	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:59763235G>A	uc002izk.1	-	19	3008	c.2867C>T	c.(2866-2868)TCA>TTA	p.S956L	BRIP1_uc002izl.1_Missense_Mutation_p.S337L	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	956	Interaction with BRCA1.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						TGGTAGAGGTGAATTTTTGGT	0.348			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				11	102					0	0	0.004007	0	0
MARCH10	162333	broad.mit.edu	37	17	60788599	60788599	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:60788599C>T	uc010ddr.2	-	9	2559	c.2321G>A	c.(2320-2322)AGA>AAA	p.R774K	MARCH10_uc002jag.3_Missense_Mutation_p.R774K|MARCH10_uc010dds.2_Missense_Mutation_p.R812K|MARCH10_uc002jah.2_Missense_Mutation_p.R773K|uc002jaj.1_Intron|uc002jak.2_Intron	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	774							ligase activity|zinc ion binding				0						TACCCTCTCTCTTTCCACCTG	0.527													5	71					0	0	0.001984	0	0
ACE	1636	broad.mit.edu	37	17	61557816	61557816	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:61557816C>T	uc002jau.1	+	5	796	c.774C>T	c.(772-774)GTC>GTT	p.V258V	ACE_uc010wpi.1_Silent_p.V258V|ACE_uc010ddu.1_Silent_p.V75V	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	258	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	ATGCCTTCGTCCGCCGCGCAC	0.602													8	58					0	0	0.004482	0	0
ACE	1636	broad.mit.edu	37	17	61558931	61558931	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:61558931G>A	uc002jau.1	+	7	972	c.950G>A	c.(949-951)TGG>TAG	p.W317*	ACE_uc010wpi.1_Nonsense_Mutation_p.W317*|ACE_uc010ddu.1_Nonsense_Mutation_p.W134*	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	317	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CTCCAGGGCTGGAACGCCACG	0.657													5	21					0	0	0.000602	0	0
MAP3K3	4215	broad.mit.edu	37	17	61770952	61770952	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:61770952C>T	uc002jbg.2	+	16	2015	c.1696C>T	c.(1696-1698)CCG>TCG	p.P566S	MAP3K3_uc002jbe.2_Missense_Mutation_p.P597S|MAP3K3_uc002jbf.2_Missense_Mutation_p.P597S|MAP3K3_uc002jbh.2_Missense_Mutation_p.P593S|MAP3K3_uc010wpo.1_Missense_Mutation_p.P481S|MAP3K3_uc010wpp.1_Missense_Mutation_p.P562S	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	566	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6						AGAGAAACCACCGTGGGCAGA	0.597													27	64					0	0	0.008361	0	0
CCDC47	57003	broad.mit.edu	37	17	61829717	61829717	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:61829717G>A	uc002jbs.3	-	11	1502	c.1166C>T	c.(1165-1167)TCT>TTT	p.S389F	CCDC47_uc010ddx.2_Missense_Mutation_p.S389F|CCDC47_uc002jbt.2_Missense_Mutation_p.S389F	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	389						integral to membrane	protein binding				0						TTTATCAATAGAATAAATCAC	0.418													14	90					0	0	0.004990	0	0
GH2	2689	broad.mit.edu	37	17	61958427	61958427	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:61958427G>A	uc002jco.1	-	3	315	c.253C>T	c.(253-255)CCA>TCA	p.P85S	GH2_uc002jcj.2_Missense_Mutation_p.P85S|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_Missense_Mutation_p.P85S|GH2_uc002jcm.1_Missense_Mutation_p.P85S|GH2_uc002jcn.1_Missense_Mutation_p.P70S	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	85						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						GAAGGTGTTGGAATAGACTCT	0.552													52	147					0	0	0.014410	0	0
SCN4A	6329	broad.mit.edu	37	17	62018440	62018440	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:62018440G>A	uc002jds.1	-	24	5279	c.5202C>T	c.(5200-5202)ATC>ATT	p.I1734I		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1734	IQ.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	AGGCCCTCTGGATCTTGATGG	0.622													9	65					0	0	0.006214	0	0
RGS9	8787	broad.mit.edu	37	17	63198127	63198127	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:63198127C>G	uc002jfe.2	+	14	1103	c.993C>G	c.(991-993)TTC>TTG	p.F331L	RGS9_uc010dem.2_Missense_Mutation_p.F328L|RGS9_uc002jfd.2_Missense_Mutation_p.F328L|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.F102L	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	331	RGS.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						ATCTGGGATTCTGGGAAGCCT	0.483													6	54					0	0	0.006214	0	0
AXIN2	8313	broad.mit.edu	37	17	63554133	63554134	+	Missense_Mutation	DNP	AC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:63554133_63554134AC>TT	uc002jfi.2	-	2	894_895	c.605_606GT>AA	c.(604-606)AGT>AAA	p.S202K	AXIN2_uc010den.1_Missense_Mutation_p.S202K|AXIN2_uc002jfh.2_Missense_Mutation_p.S202K|AXIN2_uc002jfj.1_Missense_Mutation_p.S202K	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	202					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						TTTCTCCCCCACTCCTCACATA	0.485									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				11	60					0	0	0.004672	0	0
CCDC46	201134	broad.mit.edu	37	17	64026062	64026062	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:64026062T>A	uc002jfl.2	-	13	1517	c.1298A>T	c.(1297-1299)AAA>ATA	p.K433I	CCDC46_uc010deo.2_Missense_Mutation_p.K175I|CCDC46_uc002jfm.2_Missense_Mutation_p.K433I|CCDC46_uc010dep.2_Missense_Mutation_p.K391I	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	433	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			TTGAATTAATTTCTGCCTCTG	0.383													16	57					0	0	0.004007	0	0
ABCA9	10350	broad.mit.edu	37	17	67014721	67014721	+	Splice_Site	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:67014721C>T	uc002jhu.2	-	20	2744	c.2601_splice	c.e20-1	p.I867_splice	ABCA9_uc010dez.2_Splice_Site_p.I867_splice	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9						transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					AAGCAATAATCTATGCAGAGG	0.289													27	159					0	0	0.003954	0	0
ABCA6	23460	broad.mit.edu	37	17	67084376	67084376	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:67084376G>A	uc002jhw.1	-	28	3805	c.3630C>T	c.(3628-3630)TTC>TTT	p.F1210F		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1210	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					GAACAAAAACGAATAGCAAAG	0.299													5	18					0	0	0.001984	0	0
ABCA5	23461	broad.mit.edu	37	17	67247981	67247981	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:67247981T>C	uc002jif.2	-	34	5660	c.4442A>G	c.(4441-4443)AAC>AGC	p.N1481S	ABCA5_uc002jib.2_Missense_Mutation_p.N447S|ABCA5_uc002jic.2_Missense_Mutation_p.N704S|ABCA5_uc002jid.2_Missense_Mutation_p.N398S|ABCA5_uc002jie.2_Intron|ABCA5_uc002jig.2_Missense_Mutation_p.N1481S	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	1481	ABC transporter 2.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					CCGCTTTCTGTTTTTAAATGC	0.388													3	36					0	0	0.004672	0	0
MAP2K6	5608	broad.mit.edu	37	17	67537885	67537885	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:67537885T>C	uc002jij.2	+	12	1284	c.996T>C	c.(994-996)CTT>CTC	p.L332L		NM_002758	NP_002749	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	332					activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|pancreas(1)	5	Breast(10;6.05e-10)					AACTGATTCTTGGAGACTAAA	0.388													3	45					0	0	0.009096	0	0
OTOP3	347741	broad.mit.edu	37	17	72943324	72943324	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:72943324C>T	uc010wrr.1	+	6	1374	c.1374C>T	c.(1372-1374)ATC>ATT	p.I458I	OTOP3_uc010wrq.1_Silent_p.I440I	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	458	Helical; (Potential).					integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					TGCTGCTCATCCTGCAGCACA	0.627													4	16					0	0	0.009096	0	0
OTOP3	347741	broad.mit.edu	37	17	72945374	72945374	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:72945374G>A	uc010wrr.1	+	7	1654	c.1654G>A	c.(1654-1656)GAG>AAG	p.E552K	OTOP3_uc010wrq.1_Missense_Mutation_p.E534K	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	552						integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					CATACACCCGGAGTTTGAGAA	0.557													11	76					0	0	0.010729	0	0
C17orf28	283987	broad.mit.edu	37	17	72951961	72951961	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:72951961G>A	uc002jmj.3	-	13	1711	c.1562C>T	c.(1561-1563)TCT>TTT	p.S521F	C17orf28_uc002jmi.2_5'Flank|C17orf28_uc010wrs.1_Missense_Mutation_p.S320F	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	521						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					CTGGGCGGCAGAGAAGAGGAA	0.572													4	75					0	0	0.001168	0	0
RECQL5	9400	broad.mit.edu	37	17	73625422	73625423	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:73625422_73625423GG>AA	uc010dgl.2	-	16	2236_2237	c.2080_2081CC>TT	c.(2080-2082)CCG>TTG	p.P694L	RECQL5_uc010dgk.2_Missense_Mutation_p.P667L|RECQL5_uc002jot.3_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	694					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			GGGCCGGCTCGGGGGCTCGTGC	0.703								Other_identified_genes_with_known_or_suspected_DNA_repair_function					8	28					0	0	0.004672	0	0
ITGB4	3691	broad.mit.edu	37	17	73727424	73727424	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:73727424C>T	uc002jpg.2	+	10	1377	c.1190C>T	c.(1189-1191)TCC>TTC	p.S397F	ITGB4_uc002jph.2_Missense_Mutation_p.S397F|ITGB4_uc010dgo.2_Missense_Mutation_p.S397F|ITGB4_uc002jpi.3_Missense_Mutation_p.S397F|ITGB4_uc010dgp.1_Missense_Mutation_p.S397F|ITGB4_uc002jpj.2_Missense_Mutation_p.S397F|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	397	Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGGACTGGGTCCTTTCACATC	0.607													4	88					0	0	0.001984	0	0
EVPL	2125	broad.mit.edu	37	17	74003351	74003351	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:74003351C>T	uc002jqi.2	-	22	6163	c.5935G>A	c.(5935-5937)GAG>AAG	p.E1979K	EVPL_uc010wss.1_Missense_Mutation_p.E2001K|EVPL_uc010wst.1_Missense_Mutation_p.E1449K	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1979	Globular 2.|Plectin 7.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						AAATCCTTCTCGTAGCTGGAC	0.642													11	91					0	0	0.001855	0	0
EVPL	2125	broad.mit.edu	37	17	74004797	74004797	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:74004797G>A	uc002jqi.2	-	22	4717	c.4489C>T	c.(4489-4491)CGG>TGG	p.R1497W	EVPL_uc010wss.1_Missense_Mutation_p.R1519W|EVPL_uc010wst.1_Missense_Mutation_p.R967W	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1497	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TTGCACTCCCGATTCAGCTCG	0.582													27	81					0	0	0.008361	0	0
EVPL	2125	broad.mit.edu	37	17	74005812	74005812	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:74005812G>A	uc002jqi.2	-	22	3702	c.3474C>T	c.(3472-3474)CTC>CTT	p.L1158L	EVPL_uc010wss.1_Silent_p.L1180L|EVPL_uc010wst.1_Silent_p.L628L	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1158	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						CCTCCTCGAGGAGGCTCCTCA	0.632													4	30					0	0	0.000602	0	0
FOXJ1	2302	broad.mit.edu	37	17	74133827	74133827	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:74133827G>A	uc002jqw.2	-	2	963	c.873C>T	c.(871-873)ACC>ACT	p.T291T	FOXJ1_uc002jqx.2_Silent_p.T291T|uc002jqy.1_5'Flank	NM_001454	NP_001445	Q92949	FOXJ1_HUMAN	forkhead box J1	291					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			pancreas(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			TGGGCAGCAGGGTGCTGGGGG	0.716													5	32					0	0	0.001984	0	0
QRICH2	84074	broad.mit.edu	37	17	74283970	74283970	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:74283970C>T	uc002jrd.1	-	6	3489	c.3309G>A	c.(3307-3309)AGG>AGA	p.R1103R	QRICH2_uc010wsz.1_Silent_p.R1029R|QRICH2_uc010dgw.1_5'UTR	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1103	Potential.						protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						TCCTCTGCAGCCTTTCCACCT	0.577													5	46					0	0	0.000602	0	0
PGS1	9489	broad.mit.edu	37	17	76395592	76395592	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:76395592C>T	uc002jvm.2	+	5	687	c.675C>T	c.(673-675)CTC>CTT	p.L225L	PGS1_uc010wtt.1_RNA|PGS1_uc010dho.2_RNA|PGS1_uc002jvn.2_5'UTR|PGS1_uc002jvo.2_RNA|PGS1_uc002jvp.1_5'Flank	NM_024419	NP_077733	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	225	PLD phosphodiesterase 1.				phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			AGGTGTACCTCTTCGACAACA	0.592													6	37					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	17	76498043	76498043	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:76498043G>A	uc002jvt.1	+	2		c.3502G>A								Homo sapiens cDNA FLJ45552 fis, clone BRTHA2038279.																		GCTGCATAGGGAACACCACCA	0.592													7	32					0	0	0.001984	0	0
SLC26A11	284129	broad.mit.edu	37	17	78220411	78220411	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:78220411C>T	uc002jyb.1	+	13	1526	c.1257C>T	c.(1255-1257)TTC>TTT	p.F419F	SLC26A11_uc002jyc.1_Silent_p.F419F|SLC26A11_uc002jyd.1_Silent_p.F419F|SLC26A11_uc010dhv.1_Silent_p.F419F	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	419	Helical; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CCCCGCTGTTCGACACCAAGA	0.577													6	15					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	17	78268715	78268715	+	Silent	SNP	C	T	T	rs146798784	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:78268715C>T	uc002jyf.2	+	9	1811	c.1668C>T	c.(1666-1668)TTC>TTT	p.F556F	uc002jyg.1_Silent_p.F287F	NM_020954	NP_066005			hypothetical protein LOC57714																		TCACCCAGTTCGAGCAGTTTT	0.527													10	43					0	0	0.010729	0	0
BAIAP2	10458	broad.mit.edu	37	17	79078372	79078372	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:79078372C>T	uc002jzg.2	+	10	1233	c.1125C>T	c.(1123-1125)GGC>GGT	p.G375G	BAIAP2_uc002jyz.3_Silent_p.G375G|BAIAP2_uc002jza.2_Silent_p.G375G|BAIAP2_uc002jzc.2_Silent_p.G376G|BAIAP2_uc002jzb.2_Silent_p.G132G|BAIAP2_uc002jzd.2_Silent_p.G375G|BAIAP2_uc002jzf.2_Silent_p.G375G|BAIAP2_uc002jze.2_Silent_p.G408G|BAIAP2_uc010wuh.1_Silent_p.G297G|BAIAP2_uc002jzh.2_Silent_p.G376G|BAIAP2_uc010wui.1_Silent_p.G238G	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	375	SH3.				axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			AGCGCAATGGCCGTATGCGGG	0.637													9	46					0	0	0.001855	0	0
SECTM1	6398	broad.mit.edu	37	17	80280073	80280073	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:80280073G>A	uc002keo.2	-	5	1109	c.711C>T	c.(709-711)TCC>TCT	p.S237S	SECTM1_uc002ken.2_Silent_p.S235S|SECTM1_uc002kep.2_3'UTR	NM_003004	NP_002995	Q8WVN6	SCTM1_HUMAN	secreted and transmembrane 1 precursor	237	Cytoplasmic (Potential).				immune response|mesoderm development|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular space|Golgi apparatus|integral to membrane|plasma membrane	cytokine activity|signal transducer activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			AGGGTTGGGGGGACAGCAGCT	0.652													8	81					0	0	0.006214	0	0
ZNF750	79755	broad.mit.edu	37	17	80789372	80789372	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:80789372C>T	uc002kga.2	-	2	1270	c.959G>A	c.(958-960)GGA>GAA	p.G320E	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	320						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CCTGTAAAATCCGTAAGGAAT	0.542													16	183					0	0	0.004990	0	0
METRNL	284207	broad.mit.edu	37	17	81043044	81043044	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr17:81043044G>A	uc002kgh.2	+	2	526	c.401G>A	c.(400-402)GGG>GAG	p.G134E	METRNL_uc002kgi.2_Missense_Mutation_p.G52E	NM_001004431	NP_001004431	Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation	134						extracellular region					0	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			GTACCAGACGGGGACGGCAGG	0.637													4	54					0	0	0.009096	0	0
COLEC12	81035	broad.mit.edu	37	18	335158	335158	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:335158C>T	uc002kkm.2	-	6	1615	c.1400G>A	c.(1399-1401)GGA>GAA	p.G467E		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	467	Collagen-like 1.|Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				TCCTTTCTGTCCCTTGTTGCC	0.622													17	60					0	0	0.004990	0	0
EMILIN2	84034	broad.mit.edu	37	18	2885068	2885069	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:2885068_2885069CC>TT	uc002kln.2	+	3	523_524	c.364_365CC>TT	c.(364-366)CCC>TTC	p.P122F		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	122					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CCAAGAAGGTCCCAAAGACCCC	0.51													5	40					0	0	0.004672	0	0
LPIN2	9663	broad.mit.edu	37	18	2934435	2934435	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:2934435T>G	uc002klo.2	-	8	1421	c.1182A>C	c.(1180-1182)AGA>AGC	p.R394S		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	394					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GGTGTTGGCTTCTTTTGTGAA	0.378													3	24					0	0	0.009096	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6093488	6093488	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:6093488C>T	uc002kmz.3	-	15	1399	c.1239G>A	c.(1237-1239)AAG>AAA	p.K413K	L3MBTL4_uc010dkt.2_Silent_p.K413K|L3MBTL4_uc002kmy.3_Silent_p.K251K	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	413					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				GTGTTGCCTCCTTTTTCAAGT	0.388													6	74					0	0	0.001168	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6243311	6243311	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:6243311C>T	uc002kmz.3	-	7	602	c.442G>A	c.(442-444)GAA>AAA	p.E148K	L3MBTL4_uc010dkt.2_Missense_Mutation_p.E148K|L3MBTL4_uc002kmy.3_5'Flank	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	148	MBT 1.				chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				ATGTGCAGTTCATGTTTGGTC	0.358													7	67					0	0	0.001984	0	0
LAMA1	284217	broad.mit.edu	37	18	6942202	6942202	+	Missense_Mutation	SNP	G	A	A	rs147708500		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:6942202G>A	uc002knm.2	-	63	9198	c.9104C>T	c.(9103-9105)TCG>TTG	p.S3035L	LAMA1_uc002knk.2_Missense_Mutation_p.S365L|LAMA1_uc002knl.2_Missense_Mutation_p.S488L|LAMA1_uc010wzj.1_Missense_Mutation_p.S2511L	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	3035	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCGCGGAACGAGGTCTGGCT	0.483													6	29					0	0	0.001984	0	0
LRRC30	339291	broad.mit.edu	37	18	7231694	7231694	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:7231694G>A	uc010wzk.1	+	1	558	c.558G>A	c.(556-558)AAG>AAA	p.K186K		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	186										ovary(1)|liver(1)	2						TCTCCCTGAAGGAACTGATTT	0.552													5	64					0	0	0.001168	0	0
TWSG1	57045	broad.mit.edu	37	18	9396351	9396351	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:9396351G>A	uc002knz.2	+	4	488	c.297G>A	c.(295-297)CCG>CCA	p.P99P	TWSG1_uc002koa.2_Silent_p.P24P	NM_020648	NP_065699	Q9GZX9	TWSG1_HUMAN	twisted gastrulation precursor	99										ovary(1)|pancreas(1)	2						TGCATGAACCGATCCCTTCTC	0.443													6	54					0	0	0.001168	0	0
FAM38B	63895	broad.mit.edu	37	18	10696185	10696185	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:10696185C>T	uc002kor.3	-	5	749	c.609G>A	c.(607-609)GTG>GTA	p.V203V	FAM38B_uc002koq.2_Silent_p.V101V	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2246	Helical; (Potential).					integral to membrane	ion channel activity			ovary(1)	1						GGGCTCGGTCCACCACCATGG	0.512													9	28					0	0	0.004482	0	0
GNAL	2774	broad.mit.edu	37	18	11872339	11872339	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:11872339G>A	uc010dkz.2	+	11	1119	c.873G>A	c.(871-873)GGG>GGA	p.G291G	GNAL_uc002kqc.2_Silent_p.G368G|GNAL_uc002kqd.2_Silent_p.G291G|GNAL_uc010wzt.1_Silent_p.G84G	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	291					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						TCTTGGCAGGGAAATCAAAAA	0.323													6	71					0	0	0.001168	0	0
AFG3L2	10939	broad.mit.edu	37	18	12353120	12353120	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:12353120G>A	uc002kqz.1	-	10	1315	c.1202C>T	c.(1201-1203)CCT>CTT	p.P401L		NM_006796	NP_006787	Q9Y4W6	AFG32_HUMAN	AFG3 ATPase family gene 3-like 2	401					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)	GAGGATGCAAGGGGCATTCTT	0.473													4	65					0	0	0.000602	0	0
CEP192	55125	broad.mit.edu	37	18	13040926	13040926	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:13040926T>G	uc010xac.1	+	14	1987	c.1907T>G	c.(1906-1908)ATG>AGG	p.M636R	CEP192_uc010dlf.1_Intron|CEP192_uc010xad.1_Missense_Mutation_p.M161R|CEP192_uc002kru.2_RNA|CEP192_uc002krs.1_Missense_Mutation_p.M377R	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	636								p.T636R(1)		ovary(4)|pancreas(1)	5						GAAAAAGAAATGGCTCATCTT	0.338													11	64					0	0	0.001855	0	0
CEP192	55125	broad.mit.edu	37	18	13055828	13055828	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:13055828C>T	uc010xac.1	+	19	3319	c.3239C>T	c.(3238-3240)GCC>GTC	p.A1080V	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.A605V|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Missense_Mutation_p.A821V	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1080										ovary(4)|pancreas(1)	5						GGCAGTCCAGCCGCATTGGAG	0.353													7	35					0	0	0.004482	0	0
CTAGE1	64693	broad.mit.edu	37	18	19996364	19996364	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:19996364G>A	uc002ktv.1	-	1	1515	c.1411C>T	c.(1411-1413)CCT>TCT	p.P471S		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	471						integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AGTCCATAAGGATCTTTTTCT	0.373													5	61					0	0	0.000602	0	0
LAMA3	3909	broad.mit.edu	37	18	21469984	21469985	+	Missense_Mutation	DNP	GG	AA	AA	rs141738236		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:21469984_21469985GG>AA	uc002kuq.2	+	42	5399_5400	c.5313_5314GG>AA	c.(5311-5316)CCGGGA>CCAAGA	p.G1772R	LAMA3_uc002kur.2_Missense_Mutation_p.G1772R|LAMA3_uc002kus.3_Missense_Mutation_p.G163R|LAMA3_uc002kut.3_Missense_Mutation_p.G163R	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1772	Laminin EGF-like 14.|Domain III A.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGTGCACCGGGATATTTCGG	0.47													6	89					0	0	0.004672	0	0
LAMA3	3909	broad.mit.edu	37	18	21495273	21495273	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:21495273C>T	uc002kuq.2	+	59	7751	c.7665C>T	c.(7663-7665)TTC>TTT	p.F2555F	LAMA3_uc002kur.2_Silent_p.F2499F|LAMA3_uc002kus.3_Silent_p.F946F|LAMA3_uc002kut.3_Silent_p.F890F	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2555	Laminin G-like 1.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GACTAAGTTTCCCTCCATACA	0.328													4	34					0	0	0.001168	0	0
ZNF521	25925	broad.mit.edu	37	18	22806712	22806712	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:22806712G>A	uc002kvk.2	-	4	1417	c.1170C>T	c.(1168-1170)ACC>ACT	p.T390T	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.T390T|ZNF521_uc002kvl.2_Silent_p.T170T	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	390					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCATGTCAGGGGTTTGTTGAG	0.493			T	PAX5	ALL								5	56					0	0	0.001984	0	0
DSC3	1825	broad.mit.edu	37	18	28598661	28598661	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:28598661C>T	uc002kwj.3	-	8	1203	c.1048G>A	c.(1048-1050)GAT>AAT	p.D350N	DSC3_uc002kwi.3_Missense_Mutation_p.D350N	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	350	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GGTGCATTATCATTTGAATCT	0.308													8	38					0	0	0.003080	0	0
DSC1	1823	broad.mit.edu	37	18	28737462	28737462	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:28737462C>T	uc002kwn.2	-	3	485	c.223G>A	c.(223-225)GGC>AGC	p.G75S	DSC1_uc002kwm.2_Missense_Mutation_p.G75S	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	75					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TAAATTGAGCCATCTTCTAGA	0.438													4	66					0	0	0.009096	0	0
DSG1	1828	broad.mit.edu	37	18	28934476	28934476	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:28934476C>T	uc002kwp.2	+	15	2529	c.2317C>T	c.(2317-2319)CCT>TCT	p.P773S	DSG1_uc010xbp.1_Missense_Mutation_p.P132S	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	773	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AGACCTTGATCCTTCTTGGCC	0.488													7	71					0	0	0.003080	0	0
DSG4	147409	broad.mit.edu	37	18	28972242	28972242	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:28972242G>A	uc002kwq.2	+	8	1079	c.944G>A	c.(943-945)GGG>GAG	p.G315E	DSG4_uc002kwr.2_Missense_Mutation_p.G315E	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	315	Cadherin 3.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGAAATGATGGGAATTGGTTC	0.348													8	23					0	0	0.004482	0	0
DSG3	1830	broad.mit.edu	37	18	29056125	29056125	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:29056125C>T	uc002kws.2	+	16	3011	c.2902C>T	c.(2902-2904)CCC>TCC	p.P968S	DSG3_uc002kwt.2_Missense_Mutation_p.P250S	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	968	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGTGATCTGTCCCATTTCCAG	0.512													5	76					0	0	0.000602	0	0
FAM59A	64762	broad.mit.edu	37	18	29867099	29867099	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:29867099G>A	uc002kxl.2	-	4	1517	c.1461C>T	c.(1459-1461)TCC>TCT	p.S487S	FAM59A_uc002kxk.1_Silent_p.S487S	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	487										ovary(1)|skin(1)	2						TCGCACATTTGGATCGGACAG	0.547													10	83					0	0	0.013537	0	0
C18orf34	374864	broad.mit.edu	37	18	30672850	30672850	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:30672850C>T	uc002kxn.2	-	20	2405	c.2263G>A	c.(2263-2265)GAA>AAA	p.E755K	C18orf34_uc010xbq.1_Intron|C18orf34_uc010dme.1_Intron|C18orf34_uc010xbr.1_Missense_Mutation_p.E755K|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.E717K|C18orf34_uc002kxp.2_Missense_Mutation_p.E755K	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	755										ovary(1)	1						CGCAGATTTTCTTCAAGTGAA	0.259													4	35					0	0	0.009096	0	0
NOL4	8715	broad.mit.edu	37	18	31685048	31685048	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:31685048C>T	uc010dmi.2	-	3	720	c.491G>A	c.(490-492)AGA>AAA	p.R164K	NOL4_uc002kxr.3_5'UTR|NOL4_uc010xbt.1_Missense_Mutation_p.R90K|NOL4_uc010dmh.2_Missense_Mutation_p.R90K|NOL4_uc010xbu.1_Missense_Mutation_p.R164K|NOL4_uc002kxt.3_Missense_Mutation_p.R164K|NOL4_uc010xbw.1_Missense_Mutation_p.R50K	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	164						nucleolus	RNA binding			ovary(3)	3						TAAATGCATTCTTTTCTGGCA	0.383													5	53					0	0	0.001168	0	0
ZNF24	7572	broad.mit.edu	37	18	32920427	32920427	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:32920427G>A	uc002kyt.2	-	2	345	c.188C>T	c.(187-189)TCA>TTA	p.S63L	ZNF24_uc002kys.2_Missense_Mutation_p.S63L|ZNF24_uc002kyu.1_Missense_Mutation_p.S63L	NM_006965	NP_008896	P17028	ZNF24_HUMAN	zinc finger protein 24	63	SCAN box.				myelination|negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGGCCCAGGTGAATCCTGGTA	0.552													12	59					0	0	0.013537	0	0
PIAS2	9063	broad.mit.edu	37	18	44426698	44426698	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:44426698G>A	uc002lck.2	-	6	991	c.833C>T	c.(832-834)TCC>TTC	p.S278F	PIAS2_uc010dnp.2_5'UTR|PIAS2_uc002lcl.2_Missense_Mutation_p.S278F|PIAS2_uc010xda.1_5'UTR|PIAS2_uc002lcm.2_Missense_Mutation_p.S278F|PIAS2_uc002lcn.1_Missense_Mutation_p.S282F	NM_004671	NP_004662	O75928	PIAS2_HUMAN	protein inhibitor of activated STAT X isoform	278	PINIT.				androgen receptor signaling pathway|negative regulation of androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|PML body	androgen receptor binding|DNA binding|protein binding|SUMO ligase activity|transcription coactivator activity|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						CCAAGAAATGGAAATTTGGTT	0.453													5	51					0	0	0.001984	0	0
LIPG	9388	broad.mit.edu	37	18	47101747	47101748	+	Missense_Mutation	DNP	CC	TA	TA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:47101747_47101748CC>TA	uc002ldv.2	+	5	832_833	c.580_581CC>TA	c.(580-582)CCT>TAT	p.P194Y	LIPG_uc002ldu.1_Missense_Mutation_p.P194Y|LIPG_uc010xdh.1_Intron	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	194					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						AGGTTTGGATCCTGCCGGGCCC	0.554													5	20					0	0	0.004672	0	0
MYO5B	4645	broad.mit.edu	37	18	47488732	47488732	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:47488732G>A	uc002leb.2	-	12	1737	c.1449C>T	c.(1447-1449)ATC>ATT	p.I483I	MYO5B_uc002lec.1_Silent_p.I482I	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	483	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GGGTCCAAGGGATCTGTTCCT	0.428													4	28					0	0	0.009096	0	0
MYO5B	4645	broad.mit.edu	37	18	47563245	47563245	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:47563245C>T	uc002leb.2	-	4	718	c.430G>A	c.(430-432)GAA>AAA	p.E144K	MYO5B_uc002lec.1_Missense_Mutation_p.E143K	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	144	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TAGGCTTCTTCTGCCACAGCA	0.493													5	44					0	0	0.001984	0	0
CCDC11	220136	broad.mit.edu	37	18	47788366	47788366	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:47788366C>T	uc002lee.2	-	2	384	c.293G>A	c.(292-294)CGA>CAA	p.R98Q		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	98	Potential.									ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		TTACTTATTTCGTCTTTCTTC	0.393													6	60					0	0	0.001168	0	0
ONECUT2	9480	broad.mit.edu	37	18	55103799	55103799	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:55103799C>T	uc002lgo.2	+	1	883	c.851C>T	c.(850-852)CCA>CTA	p.P284L		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	284					organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		CTGGGCACCCCACCTGCGGCC	0.701													5	58					0	0	0.003080	0	0
ALPK2	115701	broad.mit.edu	37	18	56203775	56203775	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:56203775G>A	uc002lhj.3	-	5	3858	c.3644C>T	c.(3643-3645)TCT>TTT	p.S1215F	ALPK2_uc002lhk.1_Missense_Mutation_p.S546F	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1215							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						AAGGATATCAGAGAGAGATGG	0.512													12	92					0	0	0.010729	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60241435	60241435	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:60241435C>T	uc002lip.3	+	13	2121	c.2121C>T	c.(2119-2121)CCC>CCT	p.P707P	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Silent_p.P177P	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	707					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						TAGAAGATCCCTTAAACTCAC	0.438													19	94					0	0	0.014323	0	0
SERPINB5	5268	broad.mit.edu	37	18	61160312	61160312	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:61160312C>T	uc002liz.3	+	5	693	c.551C>T	c.(550-552)CCT>CTT	p.P184L	SERPINB5_uc002liy.2_Missense_Mutation_p.P184L	NM_002639	NP_002630	P36952	SPB5_HUMAN	serine (or cysteine) proteinase inhibitor, clade	184					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1						AAAGAATGTCCTTTCAGAGTC	0.408													5	49					0	0	0.000602	0	0
SERPINB11	89778	broad.mit.edu	37	18	61379812	61379812	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:61379812G>A	uc002ljk.3	+	4	304	c.242G>A	c.(241-243)GGA>GAA	p.G81E	SERPINB11_uc010xes.1_5'UTR|SERPINB11_uc010dqd.2_5'UTR|SERPINB11_uc002ljj.3_5'UTR|SERPINB11_uc010dqe.2_5'UTR|SERPINB11_uc010dqf.2_Intron	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	81					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				AGCCAAGCTGGAAGAATTCAT	0.418													11	56					0	0	0.008291	0	0
SERPINB11	89778	broad.mit.edu	37	18	61390410	61390410	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:61390410G>A	uc002ljk.3	+	9	1018	c.956G>A	c.(955-957)GGA>GAA	p.G319E	SERPINB11_uc010xes.1_Missense_Mutation_p.G144E|SERPINB11_uc010dqd.2_Intron|SERPINB11_uc002ljj.3_Missense_Mutation_p.G205E|SERPINB11_uc010dqe.2_Missense_Mutation_p.G118E|SERPINB11_uc010dqf.2_Missense_Mutation_p.G117E	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	319					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				GATCTTTCTGGAATGTCACCA	0.478													5	13					0	0	0.000602	0	0
SERPINB8	5271	broad.mit.edu	37	18	61649006	61649006	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:61649006T>A	uc002ljv.2	+	4	527	c.358T>A	c.(358-360)TCC>ACC	p.S120T	SERPINB8_uc002ljs.1_Missense_Mutation_p.S120T|SERPINB8_uc002ljt.2_Missense_Mutation_p.S120T|SERPINB8_uc002lju.2_Missense_Mutation_p.S120T|SERPINB8_uc010xex.1_5'UTR	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	120					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				GGAGGAGTTGTCCTTTGCTGA	0.418													9	79					0	0	0.004482	0	0
CDH7	1005	broad.mit.edu	37	18	63477217	63477217	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:63477217C>T	uc002ljz.2	+	3	813	c.488C>T	c.(487-489)CCC>CTC	p.P163L	CDH7_uc002lka.2_Missense_Mutation_p.P163L|CDH7_uc002lkb.2_Missense_Mutation_p.P163L	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	163	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GCAGGAGTTCCCGAAATGTCT	0.428													9	109					0	0	0.008291	0	0
CDH7	1005	broad.mit.edu	37	18	63477230	63477230	+	Silent	SNP	C	T	T	rs140800301		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:63477230C>T	uc002ljz.2	+	3	826	c.501C>T	c.(499-501)CCC>CCT	p.P167P	CDH7_uc002lka.2_Silent_p.P167P|CDH7_uc002lkb.2_Silent_p.P167P	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	167	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				AAATGTCTCCCGTGGGTAAGT	0.393													6	101					0	0	0.001168	0	0
SOCS6	9306	broad.mit.edu	37	18	67993118	67993118	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:67993118C>T	uc002lkr.1	+	2	1530	c.1214C>T	c.(1213-1215)TCT>TTT	p.S405F	SOCS6_uc010dqq.2_Missense_Mutation_p.S405F	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	405	SH2.				defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				CCAGATGGTTCTTTTCTTGTT	0.468													7	49					0	0	0.001984	0	0
SALL3	27164	broad.mit.edu	37	18	76757135	76757135	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:76757135C>T	uc002lmt.2	+	3	3716	c.3716C>T	c.(3715-3717)CCC>CTC	p.P1239L	SALL3_uc010dra.2_Missense_Mutation_p.P774L	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGCGGCATCCCCCAGCTCCCC	0.617													4	83					0	0	0.001168	0	0
NFATC1	4772	broad.mit.edu	37	18	77170533	77170533	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:77170533C>T	uc010xfg.1	+	2	711	c.258C>T	c.(256-258)CCC>CCT	p.P86P	NFATC1_uc002lnc.1_Silent_p.P86P|NFATC1_uc010xff.1_Silent_p.P86P|NFATC1_uc002lnd.2_Silent_p.P86P|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Silent_p.P86P|NFATC1_uc010xfi.1_Silent_p.P73P|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Silent_p.P73P|NFATC1_uc002lng.2_Silent_p.P73P|NFATC1_uc010xfk.1_Silent_p.P73P	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	86					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CGGATCACCCCTCGGGGTACG	0.726													6	43					0	0	0.001984	0	0
OR4F17	81099	broad.mit.edu	37	19	110767	110767	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:110767G>A	uc002loc.1	+	1	89	c.89G>A	c.(88-90)GGA>GAA	p.G30E	OR4F17_uc002lob.1_Missense_Mutation_p.G30E	NM_001005240	NP_001005240	Q8NGA8	O4F17_HUMAN	olfactory receptor, family 4, subfamily F,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTATGGAGGAATCGTGTTT	0.413													12	384					0	0	0.004990	0	0
PPAP2C	8612	broad.mit.edu	37	19	288022	288023	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:288022_288023GG>AA	uc002loi.2	-	2	300_301	c.201_202CC>TT	c.(199-204)ATCCTT>ATTTTT	p.L68F	PPAP2C_uc002loh.2_Missense_Mutation_p.L89F|PPAP2C_uc002loj.2_Missense_Mutation_p.L12F	NM_003712	NP_003703	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C isoform 1	68	Helical; (Potential).				sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCCTTACAAGGATGACGGTGG	0.649													5	56					0	0	0.004672	0	0
MIER2	54531	broad.mit.edu	37	19	313599	313599	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:313599G>A	uc002lok.1	-	8	709	c.700C>T	c.(700-702)CCT>TCT	p.P234S		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	234	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCTCTCAGGGAGGACGCTG	0.617													11	50					0	0	0.010729	0	0
MIER2	54531	broad.mit.edu	37	19	313632	313632	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:313632C>T	uc002lok.1	-	8	676	c.667G>A	c.(667-669)GAA>AAA	p.E223K		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	223	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTGGTCTTCGTTCTCGTAG	0.622													10	42					0	0	0.010729	0	0
C19orf21	126353	broad.mit.edu	37	19	758707	758707	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:758707G>A	uc002lpo.2	+	2	1844	c.1761G>A	c.(1759-1761)AGG>AGA	p.R587R		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	587										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAACTCCAGGAGCTCCTCCC	0.622													4	24					0	0	0.001168	0	0
PTBP1	5725	broad.mit.edu	37	19	804074	804074	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:804074C>G	uc002lpr.2	+	4	260	c.154C>G	c.(154-156)CGA>GGA	p.R52G	PTBP1_uc002lpp.2_Missense_Mutation_p.R52G|PTBP1_uc002lpq.2_Missense_Mutation_p.R52G|PTBP1_uc002lps.2_Intron|PTBP1_uc002lpt.2_RNA|PTBP1_uc002lpu.1_Missense_Mutation_p.R22G	NM_031991	NP_114368	P26599	PTBP1_HUMAN	polypyrimidine tract-binding protein 1 isoform	52					negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			kidney(1)|skin(1)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTGACAGCCGAAGTGCAGG	0.587													7	37					0	0	0.003080	0	0
AZU1	566	broad.mit.edu	37	19	828240	828240	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:828240C>T	uc002lpz.1	+	2	85	c.69C>T	c.(67-69)CCC>CCT	p.P23P		NM_001700	NP_001691	P20160	CAP7_HUMAN	azurocidin 1 preproprotein	23					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			pancreas(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCCAGCCCCCTTTTGGACA	0.647													6	86					0	0	0.001168	0	0
JSRP1	126306	broad.mit.edu	37	19	2252649	2252649	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:2252649C>T	uc002lvi.1	-	6	710	c.675G>A	c.(673-675)GAG>GAA	p.E225E	JSRP1_uc002lvj.1_Silent_p.E225E	NM_144616	NP_653217	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	225	Arg-rich.					sarcoplasmic reticulum membrane				pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCACACGGTCCTCCCGGACGG	0.677													29	71					0	0	0.008361	0	0
C19orf35	374872	broad.mit.edu	37	19	2276335	2276335	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:2276335C>T	uc002lvn.2	-	4	866	c.766G>A	c.(766-768)GAG>AAG	p.E256K	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	256										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGGAACCTCGGCTGCCAGC	0.701													3	8					0	0	0.004672	0	0
ZNF554	115196	broad.mit.edu	37	19	2832352	2832352	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:2832352C>T	uc002lwm.2	+	4	503	c.305C>T	c.(304-306)TCC>TTC	p.S102F	ZNF554_uc002lwl.2_Missense_Mutation_p.S51F	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	102	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCCACTTTCCCCAGCACAA	0.438													19	83					0	0	0.012319	0	0
ZNF77	58492	broad.mit.edu	37	19	2934073	2934073	+	Missense_Mutation	SNP	G	A	A	rs142377561		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:2934073G>A	uc002lws.3	-	4	1183	c.1052C>T	c.(1051-1053)CCC>CTC	p.P351L		NM_021217	NP_067040	Q15935	ZNF77_HUMAN	zinc finger protein 77	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		ACATTCATAGGGTTTCTCTCC	0.507													5	45					0	0	0.001168	0	0
TJP3	27134	broad.mit.edu	37	19	3730061	3730061	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:3730061C>T	uc010xhv.1	+	3	251	c.251C>T	c.(250-252)TCC>TTC	p.S84F	TJP3_uc010xhs.1_Missense_Mutation_p.S65F|TJP3_uc010xht.1_Missense_Mutation_p.S29F|TJP3_uc010xhu.1_Missense_Mutation_p.S74F|TJP3_uc010xhw.1_Missense_Mutation_p.S84F	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	65	PDZ 1.					tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		AACGGGGTTTCCATGGAGAAT	0.587													14	69					0	0	0.003163	0	0
TJP3	27134	broad.mit.edu	37	19	3736275	3736275	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:3736275C>G	uc010xhv.1	+	10	1339	c.1339C>G	c.(1339-1341)CCG>GCG	p.P447A	TJP3_uc010xhs.1_Missense_Mutation_p.P414A|TJP3_uc010xht.1_Missense_Mutation_p.P378A|TJP3_uc010xhu.1_Missense_Mutation_p.P423A|TJP3_uc010xhw.1_Missense_Mutation_p.P433A	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	428	PDZ 3.					tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGGGCAGCCCGGCCGACGG	0.687													4	26					0	0	0.009096	0	0
EEF2	1938	broad.mit.edu	37	19	3976654	3976654	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:3976654G>A	uc002lze.2	-	15	2558	c.2475C>T	c.(2473-2475)TTC>TTT	p.F825F		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	825						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCTGTTGTCGAAGGGGTCTC	0.637													5	6					0	0	0.000602	0	0
PLIN4	729359	broad.mit.edu	37	19	4511880	4511880	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:4511880C>T	uc002mar.1	-	3	2050	c.2050G>A	c.(2050-2052)GAC>AAC	p.D684N	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	684	18.|27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane					0						GTGACTGTGTCCTTGGTGCCG	0.582													8	196					0	0	0.003080	0	0
SAFB	6294	broad.mit.edu	37	19	5668187	5668187	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:5668187C>T	uc002mcf.2	+	21	2686	c.2633C>T	c.(2632-2634)GCC>GTC	p.A878V	SAFB_uc002mcg.2_Missense_Mutation_p.A880V|SAFB_uc002mce.3_Missense_Mutation_p.A879V|SAFB_uc010xir.1_Missense_Mutation_p.A877V|SAFB_uc010xis.1_Missense_Mutation_p.A811V|SAFB_uc010xit.1_Missense_Mutation_p.A722V|SAFB_uc010xiu.1_Missense_Mutation_p.A679V	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	878	Interaction with SAFB2.|Gly-rich.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		GGCAGCTTTGCCCCAGGCGGG	0.677													6	84					0	0	0.001168	0	0
FUT5	2527	broad.mit.edu	37	19	5867295	5867295	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:5867295A>G	uc002mdo.3	-	2	530	c.442T>C	c.(442-444)TTC>CTC	p.F148L	FUT5_uc010duo.2_Missense_Mutation_p.F148L	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	148	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						TCCATGCTGAACCAGATCCAG	0.627													11	45					0	0	0.008291	0	0
VAV1	7409	broad.mit.edu	37	19	6828176	6828176	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:6828176T>C	uc002mfu.1	+	10	1114	c.1017T>C	c.(1015-1017)CTT>CTC	p.L339L	VAV1_uc010xjh.1_Silent_p.L307L|VAV1_uc010dva.1_Silent_p.L339L|VAV1_uc002mfv.1_Silent_p.L284L	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	339	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity	p.L339L(1)		lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						ATCACCTCCTTCTCCAGGTGC	0.567													4	31					0	0	0.009096	0	0
VAV1	7409	broad.mit.edu	37	19	6854093	6854093	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:6854093G>A	uc002mfu.1	+	26	2565	c.2468G>A	c.(2467-2469)GGG>GAG	p.G823E	VAV1_uc010xjh.1_Missense_Mutation_p.G791E|VAV1_uc010dva.1_Missense_Mutation_p.G801E|VAV1_uc002mfv.1_Missense_Mutation_p.G768E	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	823	SH3 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						TGGTGGCGAGGGGAGATCTAT	0.612													12	36					0	0	0.001855	0	0
STXBP2	6813	broad.mit.edu	37	19	7703652	7703652	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:7703652G>A	uc002mha.3	+	2	123	c.78G>A	c.(76-78)GGG>GGA	p.G26G	STXBP2_uc002mhb.3_Silent_p.G26G|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Silent_p.G26G|STXBP2_uc010dvk.2_Intron|STXBP2_uc002mhc.3_5'UTR|STXBP2_uc010dvl.1_5'Flank	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	26					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						AGAAGGATGGGGAGTGGAAGG	0.582													8	51					0	0	0.004482	0	0
FBN3	84467	broad.mit.edu	37	19	8155007	8155007	+	Missense_Mutation	SNP	C	T	T	rs149936210		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:8155007C>T	uc002mjf.2	-	48	6181	c.6160G>A	c.(6160-6162)GAA>AAA	p.E2054K	FBN3_uc002mje.2_5'Flank	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2054	TB 8.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGACACAGTTCGCAGGGGTCT	0.612													7	21					0	0	0.001984	0	0
ANGPTL4	51129	broad.mit.edu	37	19	8436235	8436235	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:8436235T>C	uc002mjq.1	+	6	1063	c.868T>C	c.(868-870)TCC>CCC	p.S290P	ANGPTL4_uc002mjr.1_Missense_Mutation_p.S252P|ANGPTL4_uc010xkc.1_Missense_Mutation_p.S123P	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	290	Fibrinogen C-terminal.				angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						GCTGCAGTTCTCCGTGCACCT	0.692													7	22					0	0	0.001984	0	0
ANGPTL4	51129	broad.mit.edu	37	19	8436237	8436237	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:8436237C>T	uc002mjq.1	+	6	1065	c.870C>T	c.(868-870)TCC>TCT	p.S290S	ANGPTL4_uc002mjr.1_Silent_p.S252S|ANGPTL4_uc010xkc.1_Silent_p.S123S	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	290	Fibrinogen C-terminal.				angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						TGCAGTTCTCCGTGCACCTGG	0.692													8	22					0	0	0.003080	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8665875	8665875	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:8665875C>T	uc002mkj.1	-	6	1021	c.747G>A	c.(745-747)AAG>AAA	p.K249K	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	249	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						CCACCATCATCTTGTCAGCCA	0.627													11	74					0	0	0.001855	0	0
MUC16	94025	broad.mit.edu	37	19	9056559	9056559	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9056559C>A	uc002mkp.2	-	3	31091	c.30887G>T	c.(30886-30888)CGA>CTA	p.R10296L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10298	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGAGATGGCTCGTGGAACTCC	0.522													4	64					0.00116845	0.00125786	0.001168	1	0
MUC16	94025	broad.mit.edu	37	19	9057542	9057542	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9057542C>T	uc002mkp.2	-	3	30108	c.29904G>A	c.(29902-29904)CAG>CAA	p.Q9968Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9970	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAAGAGTACTCTGTGCTGTAG	0.468													27	200					0	0	0.010818	0	0
MUC16	94025	broad.mit.edu	37	19	9060102	9060102	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9060102G>A	uc002mkp.2	-	3	27548	c.27344C>T	c.(27343-27345)TCA>TTA	p.S9115L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9117	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTGAGTGTGAAAATCCTTG	0.498													5	38					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9065577	9065577	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9065577G>A	uc002mkp.2	-	3	22073	c.21869C>T	c.(21868-21870)TCC>TTC	p.S7290F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7292	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACCAGAGATGGATGTTCTGCT	0.463													12	47					0	0	0.013537	0	0
MUC16	94025	broad.mit.edu	37	19	9066477	9066477	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9066477G>A	uc002mkp.2	-	3	21173	c.20969C>T	c.(20968-20970)TCC>TTC	p.S6990F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6992	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTACCAGAGGAGGTGACTTC	0.488													12	142					0	0	0.010729	0	0
MUC16	94025	broad.mit.edu	37	19	9072101	9072101	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9072101C>T	uc002mkp.2	-	3	15549	c.15345G>A	c.(15343-15345)AAG>AAA	p.K5115K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5117	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAAAATTTCCTTTGTGTCTT	0.443													13	56					0	0	0.013537	0	0
MUC16	94025	broad.mit.edu	37	19	9083586	9083586	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9083586C>T	uc002mkp.2	-	1	8433	c.8229G>A	c.(8227-8229)TCG>TCA	p.S2743S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2743	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCACTGTGATCGAACCTTCAT	0.463													6	76					0	0	0.001168	0	0
MUC16	94025	broad.mit.edu	37	19	9084607	9084607	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9084607G>A	uc002mkp.2	-	1	7412	c.7208C>T	c.(7207-7209)TCC>TTC	p.S2403F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2403	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGATGGGGAGGAACTTGCTGT	0.458													8	20					0	0	0.003080	0	0
MUC16	94025	broad.mit.edu	37	19	9088521	9088521	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9088521C>T	uc002mkp.2	-	1	3498	c.3294G>A	c.(3292-3294)AGG>AGA	p.R1098R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1098	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATTGGCTTGTCCTTCCTGGAG	0.433													5	53					0	0	0.003080	0	0
OR7D2	162998	broad.mit.edu	37	19	9296893	9296893	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9296893T>A	uc002mkz.1	+	1	624	c.436T>A	c.(436-438)TTT>ATT	p.F146I		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	146	Helical; Name=4; (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						CCTCCTGGTTTTTGTCACCTG	0.468													30	88					0	0	0.013726	0	0
ZNF560	147741	broad.mit.edu	37	19	9577806	9577806	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9577806C>T	uc002mlp.1	-	10	2027	c.1817G>A	c.(1816-1818)GGA>GAA	p.G606E	ZNF560_uc010dwr.1_Missense_Mutation_p.G500E	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	606	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						GAAGGCTTTTCCACATTTCTT	0.408													17	71					0	0	0.007413	0	0
ZNF560	147741	broad.mit.edu	37	19	9578802	9578802	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:9578802A>G	uc002mlp.1	-	10	1031	c.821T>C	c.(820-822)TTC>TCC	p.F274S	ZNF560_uc010dwr.1_Missense_Mutation_p.F168S	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						AATCAGGCGGAAAGATTTTCC	0.373													3	52					0	0	0.004672	0	0
COL5A3	50509	broad.mit.edu	37	19	10112453	10112453	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:10112453C>T	uc002mmq.1	-	7	1040	c.954G>A	c.(952-954)ACG>ACA	p.T318T		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	318	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CCTCTAGGATCGTGGCATTGA	0.552											OREG0025228	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	80					0	0	0.010729	0	0
COL5A3	50509	broad.mit.edu	37	19	10114307	10114307	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:10114307C>T	uc002mmq.1	-	6	869	c.783G>A	c.(781-783)GGG>GGA	p.G261G		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	261	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TCCTGCCCTTCCCCTTGCGAC	0.577													5	40					0	0	0.001168	0	0
DNMT1	1786	broad.mit.edu	37	19	10270547	10270547	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:10270547G>A	uc002mng.2	-	15	1273	c.1093C>T	c.(1093-1095)CTC>TTC	p.L365F	DNMT1_uc010xlc.1_Missense_Mutation_p.L381F|DNMT1_uc002mnh.2_Missense_Mutation_p.L260F|DNMT1_uc010xld.1_Missense_Mutation_p.L365F	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	365	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CCATATTTGAGGTCAGGGTCG	0.607													13	92					0	0	0.002450	0	0
DNMT1	1786	broad.mit.edu	37	19	10270588	10270588	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:10270588G>A	uc002mng.2	-	15	1232	c.1052C>T	c.(1051-1053)CCC>CTC	p.P351L	DNMT1_uc010xlc.1_Missense_Mutation_p.P367L|DNMT1_uc002mnh.2_Missense_Mutation_p.P246L|DNMT1_uc010xld.1_Missense_Mutation_p.P351L	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	351	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	AATGCACTTGGGAGGGTGGGT	0.617													6	74					0	0	0.001984	0	0
S1PR2	9294	broad.mit.edu	37	19	10335343	10335343	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:10335343A>G	uc002mnl.2	-	2	350	c.239T>C	c.(238-240)CTA>CCA	p.L80P		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	80	Helical; Name=2; (By similarity).				activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2						GCCTGCCAGTAGATCGGAGGC	0.592													10	25					0	0	0.006214	0	0
ZGLP1	100125288	broad.mit.edu	37	19	10418878	10418878	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:10418878C>T	uc002mnw.3	-	1	1356	c.480G>A	c.(478-480)CAG>CAA	p.Q160Q	FDX1L_uc002mnx.1_RNA	NM_001103167	NP_001096637	P0C6A0	ZGLP1_HUMAN	GATA like protein-1	160					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TGGGGATGATCTGCAGGCTGG	0.632													12	68					0	0	0.002450	0	0
AP1M2	10053	broad.mit.edu	37	19	10694304	10694304	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:10694304G>A	uc002mpc.2	-	3	329	c.245C>T	c.(244-246)TCC>TTC	p.S82F	AP1M2_uc002mpd.2_Missense_Mutation_p.S82F	NM_005498	NP_005489	Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	82					cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(2)	2			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			ATACAGGAAGGAGTACACCAG	0.483													10	78					0	0	0.008291	0	0
ELAVL3	1995	broad.mit.edu	37	19	11569322	11569322	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:11569322G>A	uc002mry.1	-	4	818	c.438C>T	c.(436-438)TCC>TCT	p.S146S	ELAVL3_uc002mrx.1_Silent_p.S146S	NM_001420	NP_001411	Q14576	ELAV3_HUMAN	ELAV-like protein 3 isoform 1	146	RRM 2.				cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			ovary(1)|breast(1)|skin(1)	3						GGCCGTACTGGGAGAAGAGCT	0.622													9	63					0	0	0.006214	0	0
FBXW9	84261	broad.mit.edu	37	19	12800361	12800361	+	Silent	SNP	G	A	A	rs139718306		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:12800361G>A	uc010dyx.2	-	8	1290	c.1290C>T	c.(1288-1290)ACC>ACT	p.T430T	FBXW9_uc010xmp.1_RNA|uc002mul.1_3'UTR|FBXW9_uc002mum.1_Silent_p.T410T|FBXW9_uc002mun.1_Silent_p.T247T	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	440	WD 6.						protein binding			ovary(1)	1						TCACCCGGATGGTCTTGTCAG	0.617													10	44					0	0	0.013537	0	0
ASNA1	439	broad.mit.edu	37	19	12856529	12856529	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:12856529C>T	uc002muv.2	+	4	579	c.565C>T	c.(565-567)CGG>TGG	p.R189W	ASNA1_uc002muw.2_Missense_Mutation_p.R188W	NM_004317	NP_004308	O43681	ASNA_HUMAN	arsA arsenite transporter, ATP-binding, homolog	189					response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding	p.R189W(1)		ovary(2)	2					Adenosine triphosphate(DB00171)	GGGCCTGGGCCGGCTTATGCA	0.642													5	34					0	0	0.000602	0	0
MAST1	22983	broad.mit.edu	37	19	12976231	12976231	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:12976231C>T	uc002mvm.2	+	15	1868	c.1740C>T	c.(1738-1740)TTC>TTT	p.F580F		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	580	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						TCTACGAGTTCCTGGTGGGCT	0.592													19	71					0	0	0.007413	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13928098	13928098	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:13928098A>T	uc002mxh.1	+	7	1438	c.1249A>T	c.(1249-1251)ATT>TTT	p.I417F	ZSWIM4_uc010xng.1_Missense_Mutation_p.I340F	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	417							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CCTGGACCCCATTGGCTGCCT	0.622													7	52					0	0	0.001984	0	0
IL27RA	9466	broad.mit.edu	37	19	14157400	14157400	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:14157400C>T	uc002mxx.2	+	8	1534	c.1111C>T	c.(1111-1113)CCC>TCC	p.P371S		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	371	Extracellular (Potential).|Fibronectin type-III 2.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						GGTCCGGCTTCCCCCTGGGAA	0.622													5	52					0	0	0.000602	0	0
IL27RA	9466	broad.mit.edu	37	19	14162442	14162442	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:14162442C>T	uc002mxx.2	+	12	1975	c.1552C>T	c.(1552-1554)CTG>TTG	p.L518L		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	518	Helical; (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						GTGGAAAGTTCTGCCGGGCAT	0.413													4	44					0	0	0.001168	0	0
EMR3	84658	broad.mit.edu	37	19	14769331	14769331	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:14769331C>T	uc002mzi.3	-	5	535	c.387G>A	c.(385-387)AGG>AGA	p.R129R	EMR3_uc010dzp.2_Silent_p.R77R|EMR3_uc010xnv.1_Intron	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	129	Extracellular (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						TCACCTCTTTCCTGCCCTCGG	0.493													5	56					0	0	0.001168	0	0
SLC1A6	6511	broad.mit.edu	37	19	15061145	15061145	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:15061145G>A	uc002naa.1	-	9	1565	c.1557C>T	c.(1555-1557)ATC>ATT	p.I519I	SLC1A6_uc010dzu.1_Silent_p.I441I|SLC1A6_uc010xod.1_Silent_p.I455I	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	519					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	ACAAGTGCTCGATGACGGCCG	0.582													6	39					0	0	0.001168	0	0
CASP14	23581	broad.mit.edu	37	19	15164443	15164443	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:15164443G>A	uc010dzv.1	+	3	485	c.177_splice	c.e3+1	p.E59_splice	CASP14_uc002naf.2_Splice_Site_p.E59_splice	NM_012114	NP_036246	P31944	CASPE_HUMAN	caspase 14 precursor						apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity			skin(2)|ovary(1)|lung(1)	4						CACTGCCGAGGTATTGGGGTG	0.547													13	42					0	0	0.003163	0	0
OR10H1	26539	broad.mit.edu	37	19	15918161	15918161	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:15918161G>A	uc002nbq.2	-	1	776	c.687C>T	c.(685-687)ATC>ATT	p.I229I		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAGCAGAAGGGATCTTCAAGA	0.567													4	37					0	0	0.003080	0	0
CYP4F2	8529	broad.mit.edu	37	19	15990645	15990645	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:15990645G>A	uc002nbs.1	-	10	1228	c.1178C>T	c.(1177-1179)CCC>CTC	p.P393L	CYP4F2_uc010xot.1_Missense_Mutation_p.P244L	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	393					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CGGGACTGGGGGATGCAGCCG	0.617													4	77					0	0	0.009096	0	0
EPS15L1	58513	broad.mit.edu	37	19	16545262	16545263	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:16545262_16545263GG>AA	uc002ndz.1	-	7	417_418	c.411_412CC>TT	c.(409-414)AGCCTC>AGTTTC	p.L138F	EPS15L1_uc002ndx.2_Missense_Mutation_p.L138F|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.L28F|EPS15L1_uc010xpf.1_Missense_Mutation_p.L41F|EPS15L1_uc002nea.1_Missense_Mutation_p.L138F|EPS15L1_uc010eah.1_Missense_Mutation_p.L138F|EPS15L1_uc002neb.1_5'UTR|EPS15L1_uc002nec.1_Missense_Mutation_p.L138F	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	138	EH 2.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						ATGGGCAAGAGGCTTTCAAAAA	0.49													10	107					0	0	0.004672	0	0
NWD1	284434	broad.mit.edu	37	19	16884103	16884103	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:16884103C>T	uc002neu.3	+	11	2999	c.2577C>T	c.(2575-2577)CCC>CCT	p.P859P	NWD1_uc002net.3_Silent_p.P724P|NWD1_uc002nev.3_Silent_p.P653P			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	859							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CGGGAGGACCCCTCCGGGCAA	0.637													5	13					0	0	0.001168	0	0
SIN3B	23309	broad.mit.edu	37	19	16974544	16974544	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:16974544C>T	uc002ney.1	+	11	1430	c.1416C>T	c.(1414-1416)TTC>TTT	p.F472F	SIN3B_uc002nez.1_Silent_p.F440F|SIN3B_uc010xpi.1_Silent_p.F30F	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	472	Interaction with SDS3 and HDAC1 (By similarity).|Interaction with NCOR1 (By similarity).				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						ACTCCACGTTCGTCAGCTCCA	0.612													7	39					0	0	0.001984	0	0
SIN3B	23309	broad.mit.edu	37	19	16980351	16980352	+	Silent	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:16980351_16980352CC>TT	uc002ney.1	+	14	1997_1998	c.1983_1984CC>TT	c.(1981-1986)ATCCTG>ATTTTG	p.661_662IL>IL	SIN3B_uc002nez.1_Silent_p.629_630IL>IL|SIN3B_uc010xpi.1_Silent_p.219_220IL>IL	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	661_662					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						ACCGGCAGATCCTGGAGGACGC	0.658													6	21					0	0	0.004672	0	0
CPAMD8	27151	broad.mit.edu	37	19	17014415	17014415	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:17014415C>T	uc002nfb.2	-	34	4599	c.4567G>A	c.(4567-4569)GGG>AGG	p.G1523R	CPAMD8_uc002nfd.1_5'UTR	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1476						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						ACAAACAGCCCCGTGGGGAGG	0.627													7	46					0	0	0.003080	0	0
HAUS8	93323	broad.mit.edu	37	19	17186219	17186219	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:17186219G>A	uc002nfe.2	-	1	125	c.14C>T	c.(13-15)TCG>TTG	p.S5L	HAUS8_uc002nff.2_Missense_Mutation_p.S5L|HAUS8_uc002nfg.1_5'UTR|HAUS8_uc002nfh.1_Missense_Mutation_p.S5L|MYO9B_uc002nfi.2_5'Flank|MYO9B_uc010eak.2_5'Flank	NM_033417	NP_219485	Q9BT25	HAUS8_HUMAN	sarcoma antigen NY-SAR-48 isoform a	5					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0						GCCTCGCCCCGAGGAATCCGC	0.647													4	27					0	0	0.000602	0	0
MYO9B	4650	broad.mit.edu	37	19	17308652	17308652	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:17308652C>T	uc010eak.2	+	23	4250	c.4098C>T	c.(4096-4098)TCC>TCT	p.S1366S	MYO9B_uc002nfi.2_Silent_p.S1366S|MYO9B_uc002nfj.1_Silent_p.S1366S|MYO9B_uc002nfl.1_5'Flank	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1366	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						TCCTCCCGTCCCTGGCCAAGG	0.348													8	53					0	0	0.013537	0	0
ABHD8	79575	broad.mit.edu	37	19	17412092	17412093	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:17412092_17412093CC>TT	uc002ngb.3	-	2	573_574	c.333_334GG>AA	c.(331-336)GGGGAG>GGAAAG	p.E112K		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	112							hydrolase activity				0						GCCGGCGGCTCCCCAGAGCCAT	0.584													8	25					0	0	0.004672	0	0
NDUFA13	51079	broad.mit.edu	37	19	19627014	19627014	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:19627014C>T	uc010xqy.1	+	1	475	c.216C>T	c.(214-216)TTC>TTT	p.F72F	TSSK6_uc002nmq.2_5'Flank|TSSK6_uc002nmr.2_5'Flank|NDUFA13_uc002nms.2_Silent_p.F72F|NDUFA13_uc010xqx.1_Silent_p.F72F	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	Error:Variant_position_missing_in_Q9P0J0_after_alignment					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	TAAGTCACTTCCGCCCGGGAC	0.607													6	29					0	0	0.001168	0	0
LOC284441	284441	broad.mit.edu	37	19	20369820	20369820	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:20369820G>A	uc002nov.2	+	1	1364	c.613G>A	c.(613-615)GAA>AAA	p.E205K		NR_003128				SubName: Full=cDNA FLJ51655, highly similar to Actin-like protein 2;												0						AGAGAGATTTGAAACACCAGA	0.408													5	17					0	0	0.001168	0	0
ZNF676	163223	broad.mit.edu	37	19	22363765	22363765	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:22363765G>A	uc002nqs.1	-	3	1072	c.754C>T	c.(754-756)CCC>TCC	p.P252S		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CATTTGTAGGGTTTCTCTCCA	0.378													6	46					0	0	0.001168	0	0
ZNF99	7652	broad.mit.edu	37	19	22941498	22941498	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:22941498C>T	uc010xrh.1	-	5	940	c.940G>A	c.(940-942)GCT>ACT	p.A314T		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CACTTAAAAGCTTTACCACAT	0.378													5	33					0	0	0.001168	0	0
ZNF536	9745	broad.mit.edu	37	19	31038970	31038970	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:31038970A>G	uc002nsu.1	+	4	2582	c.2444A>G	c.(2443-2445)CAA>CGA	p.Q815R	ZNF536_uc010edd.1_Missense_Mutation_p.Q815R	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	815					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CTGTCTGGGCAACCCCCAAAT	0.572													9	84					0	0	0.006214	0	0
ZNF30	90075	broad.mit.edu	37	19	35434309	35434309	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:35434309C>T	uc010edp.1	+	5	817	c.439C>T	c.(439-441)CCC>TCC	p.P147S	ZNF30_uc002nxf.2_Missense_Mutation_p.P66S|ZNF30_uc010edq.1_Missense_Mutation_p.P148S|ZNF30_uc010edr.1_Missense_Mutation_p.P148S	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		TAGTGAAAAACCCAACAGATG	0.363													7	48					0	0	0.001984	0	0
MAG	4099	broad.mit.edu	37	19	35791122	35791122	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:35791122G>A	uc002nyy.1	+	6	934	c.785G>A	c.(784-786)GGG>GAG	p.G262E	MAG_uc002nyx.1_Missense_Mutation_p.G262E|MAG_uc010eds.1_Missense_Mutation_p.G237E|MAG_uc002nyz.1_Missense_Mutation_p.G262E	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	262	Ig-like C2-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CTGCTCTGTGGGGCTGACAGC	0.677													3	5					0	0	0.004672	0	0
LRFN3	79414	broad.mit.edu	37	19	36430513	36430513	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:36430513C>T	uc002oco.2	+	2	638	c.186C>T	c.(184-186)GCC>GCT	p.A62A		NM_024509	NP_078785	Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III	62	LRR 1.|Extracellular (Potential).				cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCCGGGCAGCCGAGCTGCGGC	0.701													3	13					0	0	0.004672	0	0
ZFP14	57677	broad.mit.edu	37	19	36831496	36831496	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:36831496A>G	uc002odx.1	-	4	1325	c.1232T>C	c.(1231-1233)CTT>CCT	p.L411P	ZFP14_uc010xtd.1_Missense_Mutation_p.L412P|ZFP14_uc010eex.1_Missense_Mutation_p.L411P	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	411	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					GTGTGAAATAAGCTGTGAGTA	0.403													8	49					0	0	0.003080	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643927	37643927	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:37643927G>A	uc002ofo.1	-	5	1105	c.874C>T	c.(874-876)CAT>TAT	p.H292Y	ZNF585A_uc002ofm.1_Missense_Mutation_p.H237Y|ZNF585A_uc002ofn.1_Missense_Mutation_p.H237Y	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	292	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTCCAGTATGAATTCTTCGG	0.438													23	143					0	0	0.002780	0	0
ZNF585A	199704	broad.mit.edu	37	19	37644244	37644244	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:37644244A>T	uc002ofo.1	-	5	788	c.557T>A	c.(556-558)TTT>TAT	p.F186Y	ZNF585A_uc002ofm.1_Missense_Mutation_p.F131Y|ZNF585A_uc002ofn.1_Missense_Mutation_p.F131Y	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	186	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTGCATTTAAAGGGTTTCTC	0.403													11	45					0	0	0.001855	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677345	37677345	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:37677345T>C	uc002ofq.2	-	5	1348	c.1094A>G	c.(1093-1095)TAC>TGC	p.Y365C	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.Y179C	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	365	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTCTGACCTGTAGGTAAAGGC	0.428													4	49					0	0	0.004482	0	0
ZNF607	84775	broad.mit.edu	37	19	38189016	38189017	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:38189016_38189017GG>AA	uc002ohc.1	-	5	2611_2612	c.2015_2016CC>TT	c.(2014-2016)CCC>CTT	p.P672L	ZNF607_uc002ohb.1_Missense_Mutation_p.P671L	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	672					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			TACATTTAAAGGGTTTCTCACC	0.366													7	69					0	0	0.004672	0	0
ZNF607	84775	broad.mit.edu	37	19	38190382	38190382	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:38190382C>T	uc002ohc.1	-	5	1246	c.650G>A	c.(649-651)AGA>AAA	p.R217K	ZNF607_uc002ohb.1_Missense_Mutation_p.R216K	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	217	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			ATAATGAAATCTATGATGTAC	0.423													8	48					0	0	0.003080	0	0
ZNF607	84775	broad.mit.edu	37	19	38200709	38200709	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:38200709G>A	uc002ohc.1	-	3	620	c.24C>T	c.(22-24)TTC>TTT	p.F8F	ZNF607_uc002ohb.1_Silent_p.F8F	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	8	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			CCACATCCCCGAATGTTATTG	0.383													4	43					0	0	0.000602	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38610071	38610071	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:38610071C>T	uc002ohk.2	+	9	2926	c.2417C>T	c.(2416-2418)GCC>GTC	p.A806V		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	806	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCTGAGAACGCCGCGCACAAG	0.587													5	50					0	0	0.001168	0	0
RASGRP4	115727	broad.mit.edu	37	19	38900718	38900718	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:38900718C>T	uc002oir.2	-	17	2198	c.1984G>A	c.(1984-1986)GAC>AAC	p.D662N	RASGRP4_uc010efz.1_RNA|RASGRP4_uc010ega.1_RNA|RASGRP4_uc010xua.1_Missense_Mutation_p.D593N|RASGRP4_uc010xub.1_Missense_Mutation_p.D628N|RASGRP4_uc010xuc.1_Missense_Mutation_p.D570N|RASGRP4_uc010xud.1_Missense_Mutation_p.D565N|RASGRP4_uc010xue.1_Missense_Mutation_p.D473N|RASGRP4_uc010egb.2_Missense_Mutation_p.D648N	NM_170604	NP_733749	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4 isoform a	662					activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			pancreas(1)|lung(1)|skin(1)	3	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GATGGTGGGTCCATCACCGGG	0.557													8	34					0	0	0.008291	0	0
RASGRP4	115727	broad.mit.edu	37	19	38911592	38911592	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:38911592C>T	uc002oir.2	-	4	547	c.333G>A	c.(331-333)GGG>GGA	p.G111G	RASGRP4_uc010efz.1_RNA|RASGRP4_uc010ega.1_RNA|RASGRP4_uc010xua.1_Silent_p.G111G|RASGRP4_uc010xub.1_Silent_p.G111G|RASGRP4_uc010xuc.1_Silent_p.G111G|RASGRP4_uc010xud.1_Silent_p.G111G|RASGRP4_uc010xue.1_Silent_p.G111G|RASGRP4_uc010egb.2_Silent_p.G111G	NM_170604	NP_733749	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4 isoform a	111	N-terminal Ras-GEF.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			pancreas(1)|lung(1)|skin(1)	3	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCTGGGTGTCCCCTGTGGCCT	0.587													5	37					0	0	0.001984	0	0
RYR1	6261	broad.mit.edu	37	19	38976641	38976641	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:38976641C>T	uc002oit.2	+	34	5476	c.5346C>T	c.(5344-5346)TTC>TTT	p.F1782F	RYR1_uc002oiu.2_Silent_p.F1782F	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1782	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCCCTGTTTCGTGGCCGCTC	0.682													4	25					0	0	0.009096	0	0
RYR1	6261	broad.mit.edu	37	19	38980039	38980039	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:38980039G>A	uc002oit.2	+	35	5900	c.5770G>A	c.(5770-5772)GAA>AAA	p.E1924K	RYR1_uc002oiu.2_Missense_Mutation_p.E1924K	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1924	Glu-rich (acidic).|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGGCTTGGAGGAAGGGCTGCT	0.373													5	53					0	0	0.001984	0	0
LGALS4	3960	broad.mit.edu	37	19	39297114	39297114	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:39297114G>A	uc002ojg.2	-	4	675	c.461C>T	c.(460-462)CCC>CTC	p.P154L	LGALS4_uc010xuj.1_Missense_Mutation_p.P154L	NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	154					cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GGGCCGGAGGGGCTGGCCTCC	0.463													12	105					0	0	0.013537	0	0
HNRNPL	3191	broad.mit.edu	37	19	39338074	39338075	+	Splice_Site	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:39338074_39338075CC>TT	uc010xul.1	-	2	279	c.268_splice	c.e2-1	p.E90_splice	HNRNPL_uc010xum.1_Splice_Site	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L						nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			TCGTAGTTCTCCTGAGAAAGGA	0.505													8	38					0	0	0.004672	0	0
LRFN1	57622	broad.mit.edu	37	19	39804579	39804579	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:39804579G>A	uc002okw.2	-	1	1398	c.1398C>T	c.(1396-1398)CTC>CTT	p.L466L		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	466	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			ACCTGTAGACGAGGGAGTCAT	0.632													7	16					0	0	0.004482	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39913600	39913601	+	Missense_Mutation	DNP	CC	TT	TT	rs147664004		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:39913600_39913601CC>TT	uc010xuz.1	+	18	2231_2232	c.1906_1907CC>TT	c.(1906-1908)CCT>TTT	p.P636F	PLEKHG2_uc010xuy.1_Missense_Mutation_p.P577F|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.P414F	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	636					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TACCAAAATTCCTGACGTGCCC	0.535													4	50					0	0	0.004672	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39915567	39915567	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:39915567C>T	uc010xuz.1	+	19	4119	c.3794C>T	c.(3793-3795)TCC>TTC	p.S1265F	PLEKHG2_uc010xuy.1_Intron|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.S1043F	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	1265					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCCCCACCTTCCAGCCGTCAG	0.612													16	62					0	0	0.004007	0	0
DYRK1B	9149	broad.mit.edu	37	19	40318979	40318979	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:40318979G>A	uc002omj.2	-	6	1045	c.765C>T	c.(763-765)ATC>ATT	p.I255I	DYRK1B_uc002omi.2_Silent_p.I255I|DYRK1B_uc002omk.2_Silent_p.I255I	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	255	Protein kinase.				positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CCACAATCTTGATGGCGCTGC	0.622													12	20					0	0	0.001855	0	0
MAP3K10	4294	broad.mit.edu	37	19	40719487	40719487	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:40719487C>T	uc002ona.2	+	9	2189	c.1901C>T	c.(1900-1902)TCC>TTC	p.S634F	MAP3K10_uc002onb.2_Missense_Mutation_p.S23F	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	634					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						TCGACCCCGTCCTACCTCTCA	0.522													4	16					0	0	0.009096	0	0
HIPK4	147746	broad.mit.edu	37	19	40886322	40886322	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:40886322C>T	uc002onp.2	-	3	1861	c.1576G>A	c.(1576-1578)GGA>AGA	p.G526R		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	526						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			AGATGCTCTCCTTCCTCCCAG	0.617													8	50					0	0	0.004482	0	0
CYP2B7P1	1556	broad.mit.edu	37	19	41442339	41442339	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:41442339G>A	uc010ehg.1	+	3	385	c.377G>A	c.(376-378)CGA>CAA	p.R126Q	CYP2A7_uc002opo.2_Intron|CYP2B7P1_uc010ehh.1_Missense_Mutation_p.R126Q|CYP2B7P1_uc002opq.2_RNA					SubName: Full=Cytochrome P450 2B7 short isoform; SubName: Full=CYP2B protein;											ovary(1)|skin(1)	2						GTGCTTCGGCGATTCTCTGTG	0.547													5	13					0	0	0.000602	0	0
CYP2B6	1555	broad.mit.edu	37	19	41510263	41510263	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:41510263G>A	uc002opr.1	+	3	403	c.396G>A	c.(394-396)ATG>ATA	p.M132I	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.M92I	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	132					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	TGACCACTATGAGGGACTTCG	0.562													9	17					0	0	0.008291	0	0
CEACAM6	4680	broad.mit.edu	37	19	42260627	42260627	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:42260627C>T	uc002orm.2	+	2	333	c.184C>T	c.(184-186)CGT>TGT	p.R62C		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	62	Ig-like V-type.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		GCCCCAGAATCGTATTGGTTA	0.512													8	87					0	0	0.003080	0	0
ARHGEF1	9138	broad.mit.edu	37	19	42396791	42396791	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:42396791T>C	uc002orx.2	+	7	594	c.485T>C	c.(484-486)CTC>CCC	p.L162P	ARHGEF1_uc002orw.1_Missense_Mutation_p.L162P|ARHGEF1_uc002ory.2_Missense_Mutation_p.L129P|ARHGEF1_uc002orz.2_5'UTR|ARHGEF1_uc002osa.2_Missense_Mutation_p.L177P|ARHGEF1_uc002osb.2_Missense_Mutation_p.L144P|ARHGEF1_uc002osc.2_5'Flank	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	162	RGSL.				cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		TCCAAGCGGCTCATGGGCATG	0.692													7	24					0	0	0.003080	0	0
TMEM145	284339	broad.mit.edu	37	19	42818673	42818673	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:42818673G>T	uc002otk.1	+	3	318	c.266G>T	c.(265-267)GGG>GTG	p.G89V		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	89						integral to membrane					0		Prostate(69;0.00682)				TACAAGGCAGGGGACAAGGTG	0.617													23	70					7.33628e-21	7.96429e-21	0.014323	1	0
PSG1	5669	broad.mit.edu	37	19	43382178	43382178	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:43382178G>A	uc002ovb.2	-	2	455	c.317C>T	c.(316-318)TCC>TTC	p.S106F	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.S106F|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.S106F|PSG1_uc010eio.1_Missense_Mutation_p.S106F|PSG1_uc002oux.1_Missense_Mutation_p.S35F|PSG1_uc002ouy.1_Missense_Mutation_p.S106F|PSG1_uc002ouz.1_Missense_Mutation_p.S106F|PSG1_uc002ova.1_Missense_Mutation_p.S106F|PSG1_uc002ovc.2_Missense_Mutation_p.S106F|PSG1_uc002ovd.1_Missense_Mutation_p.S106F	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	106	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GATCAGCAGGGATGCATTGGA	0.453													28	273					0	0	0.009535	0	0
PSG7	5676	broad.mit.edu	37	19	43433835	43433835	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:43433835G>A	uc002ovl.3	-	4	570	c.468C>T	c.(466-468)TTC>TTT	p.F156F	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_5'Flank|PSG7_uc002out.1_5'UTR|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Silent_p.F34F	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	156	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				CCCTGGGGTTGAAATTGCTGC	0.522													24	98					0	0	0.003954	0	0
PSG2	5670	broad.mit.edu	37	19	43579707	43579707	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:43579707C>T	uc002ovr.2	-	3	601	c.508G>A	c.(508-510)GAT>AAT	p.D170N	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Missense_Mutation_p.D170N|PSG2_uc010eiq.1_Missense_Mutation_p.D170N|PSG2_uc002ovs.3_Missense_Mutation_p.D170N|PSG2_uc002ovt.3_Missense_Mutation_p.D170N	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	170	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				GTCTCAGGATCACAGGTTAAG	0.517													15	126					0	0	0.004990	0	0
PSG5	5673	broad.mit.edu	37	19	43689184	43689184	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:43689184C>T	uc002ovu.2	-	2	311	c.180G>A	c.(178-180)CAG>CAA	p.Q60Q	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_5'UTR|PSG5_uc002ovx.2_Silent_p.Q60Q|PSG5_uc002ovv.2_Silent_p.Q60Q|PSG5_uc002ovw.2_Silent_p.Q60Q	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	60	Ig-like V-type.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				CAGCAAGATTCTGAGGCAAAT	0.448													49	71					0	0	0.014410	0	0
PSG4	5672	broad.mit.edu	37	19	43702411	43702411	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:43702411G>A	uc002ovy.2	-	3	549	c.447C>T	c.(445-447)CCC>CCT	p.P149P	PSG6_uc010xwk.1_5'UTR|PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Intron|PSG4_uc002ovz.2_Silent_p.P149P	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	149	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				TGGAGATGGAGGGCTTGGGAG	0.512													13	46					0	0	0.002450	0	0
ZNF428	126299	broad.mit.edu	37	19	44112185	44112185	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:44112185C>T	uc002oxa.2	-	3	586	c.151G>A	c.(151-153)GAG>AAG	p.E51K	SRRM5_uc002oxb.2_Intron	NM_182498	NP_872304	Q96B54	ZN428_HUMAN	zinc finger protein 428	51	Glu-rich.					intracellular	zinc ion binding				0		Prostate(69;0.0153)				tcctcttcctcctcctcctca	0.522													4	20					0	0	0.009096	0	0
ZNF285	26974	broad.mit.edu	37	19	44891169	44891169	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:44891169G>A	uc002ozd.3	-	4	1325	c.1238C>T	c.(1237-1239)TCC>TTC	p.S413F	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.S420F	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	413	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						TTGAAGAACGGAGCTTGAACT	0.493													9	34					0	0	0.008291	0	0
ZNF285	26974	broad.mit.edu	37	19	44891757	44891757	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:44891757G>A	uc002ozd.3	-	4	737	c.650C>T	c.(649-651)TCA>TTA	p.S217L	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.S224L	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						TTCAACCGTTGATTTCATACC	0.463													17	50					0	0	0.008871	0	0
RELB	5971	broad.mit.edu	37	19	45506214	45506214	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:45506214C>T	uc002paj.1	+	2	240	c.114C>T	c.(112-114)CCC>CCT	p.P38P		NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	38						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		CAGGGTCCCCCGACCTCTCCT	0.612													25	74					0	0	0.005443	0	0
FOSB	2354	broad.mit.edu	37	19	45976161	45976161	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:45976161C>T	uc002pbx.3	+	4	1500	c.908C>T	c.(907-909)TCG>TTG	p.S303L	ERCC1_uc002pbu.1_Intron|FOSB_uc010eke.2_Missense_Mutation_p.S228L|FOSB_uc002pby.3_Missense_Mutation_p.S267L|FOSB_uc010eka.1_3'UTR|FOSB_uc010ekb.1_3'UTR|FOSB_uc010ekc.1_3'UTR|FOSB_uc010ekf.2_Missense_Mutation_p.S264L|FOSB_uc010ekd.1_3'UTR|FOSB_uc010ekg.2_Missense_Mutation_p.S160L|FOSB_uc002pca.3_Missense_Mutation_p.S254L	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	303					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		TACACTTCTTCGTTTGTCCTC	0.617													20	49					0	0	0.012319	0	0
PNMAL2	57469	broad.mit.edu	37	19	46998336	46998336	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:46998336G>A	uc002pes.2	-	1	834	c.387C>T	c.(385-387)ACC>ACT	p.T129T	uc002peu.1_Silent_p.G149G	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	129										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		AAGCGGGAGGGGTGGGTGCCT	0.711													5	62					0	0	0.000602	0	0
PRKD2	25865	broad.mit.edu	37	19	47177968	47177969	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:47177968_47177969GG>AA	uc002pfh.2	-	19	2790_2791	c.2448_2449CC>TT	c.(2446-2451)CTCCGA>CTTTGA	p.R817*	PRKD2_uc002pfd.2_Nonsense_Mutation_p.R191*|PRKD2_uc010eks.2_Nonsense_Mutation_p.R220*|PRKD2_uc010ekt.2_Nonsense_Mutation_p.R84*|PRKD2_uc002pfe.2_Nonsense_Mutation_p.R347*|PRKD2_uc002pff.2_Nonsense_Mutation_p.R337*|PRKD2_uc002pfg.2_Nonsense_Mutation_p.R660*|PRKD2_uc002pfi.2_Nonsense_Mutation_p.R817*|PRKD2_uc002pfj.2_Nonsense_Mutation_p.R817*|PRKD2_uc010xye.1_Nonsense_Mutation_p.R827*|PRKD2_uc002pfk.2_Nonsense_Mutation_p.R660*	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	817					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		TCCAGCTCTCGGAGGTCCAGCC	0.604													5	18					0	0	0.004672	0	0
NPAS1	4861	broad.mit.edu	37	19	47543709	47543709	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:47543709G>A	uc002pfw.2	+	9	1166	c.970G>A	c.(970-972)GAC>AAC	p.D324N	NPAS1_uc002pfx.2_Missense_Mutation_p.D149N|NPAS1_uc002pfy.2_Missense_Mutation_p.D324N|NPAS1_uc010xyj.1_Missense_Mutation_p.D148N	NM_002517	NP_002508	Q99742	NPAS1_HUMAN	neuronal PAS domain protein 1	324	PAS 2.				central nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity				0		all_cancers(25;4.31e-08)|all_epithelial(76;2.96e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.102)		all cancers(93;6.02e-05)|OV - Ovarian serous cystadenocarcinoma(262;7.35e-05)|Epithelial(262;0.00389)|GBM - Glioblastoma multiforme(486;0.0252)		CAGAGTCAGCGACCACATGGA	0.652													3	5					0	0	0.004672	0	0
DHX34	9704	broad.mit.edu	37	19	47856294	47856294	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:47856294C>T	uc010xyn.1	+	2	348	c.7C>T	c.(7-9)CCT>TCT	p.P3S	DHX34_uc010elc.1_Missense_Mutation_p.P3S	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	3						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TAACATGCCTCCTCCTAGAAC	0.527													9	13					0	0	0.006214	0	0
FTL	2512	broad.mit.edu	37	19	49469913	49469913	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:49469913C>T	uc002plo.2	+	4	648	c.449C>T	c.(448-450)ACC>ATC	p.T150I	FTL_uc002pln.1_3'UTR	NM_000146	NP_000137	P02792	FRIL_HUMAN	ferritin, light polypeptide	150	Ferritin-like diiron.				cell death|cellular iron ion homeostasis|cellular membrane organization|iron ion transport|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|identical protein binding|oxidoreductase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000152)|all cancers(93;0.000435)|GBM - Glioblastoma multiforme(486;0.0171)|Epithelial(262;0.0267)	Iron Dextran(DB00893)	GACCACCTGACCAACCTCCAC	0.542													21	92					0	0	0.012319	0	0
KLK5	25818	broad.mit.edu	37	19	51446984	51446985	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:51446984_51446985CC>TT	uc002pue.2	-	7	1002_1003	c.784_785GG>AA	c.(784-786)GGA>AAA	p.G262K	KLK5_uc002puf.2_Missense_Mutation_p.G262K|KLK5_uc002pug.2_Missense_Mutation_p.G262K	NM_001077491	NP_001070959	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5 preproprotein	262	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		AGGGTAATCTCCCCAGGACACG	0.49													7	25					0	0	0.004672	0	0
KLK5	25818	broad.mit.edu	37	19	51452207	51452207	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:51452207T>A	uc002pue.2	-	5	718	c.500A>T	c.(499-501)AAA>ATA	p.K167I	KLK5_uc002puf.2_Missense_Mutation_p.K167I|KLK5_uc002pug.2_Missense_Mutation_p.K167I	NM_001077491	NP_001070959	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5 preproprotein	167	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		TCTGACATCTTTAGTGGGACG	0.542													9	41					0	0	0.006214	0	0
KLK7	5650	broad.mit.edu	37	19	51480880	51480880	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:51480880G>A	uc002puo.2	-	6	776	c.674C>T	c.(673-675)CCT>CTT	p.P225L	KLK7_uc002pup.2_Missense_Mutation_p.P225L|KLK7_uc010yco.1_Missense_Mutation_p.P99L|KLK7_uc010eok.2_Missense_Mutation_p.P153L	NM_139277	NP_644806	P49862	KLK7_HUMAN	stratum corneum chymotryptic enzyme	225	Peptidase S1.				epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		TTGGCCGCAAGGGAAAGTTCC	0.532													8	46					0	0	0.004482	0	0
CD33	945	broad.mit.edu	37	19	51729197	51729197	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:51729197C>T	uc002pwa.2	+	3	597	c.557C>T	c.(556-558)TCC>TTC	p.S186F	CD33_uc010eos.1_Missense_Mutation_p.S186F|CD33_uc010eot.1_Missense_Mutation_p.S59F|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	186	Extracellular (Potential).|Ig-like C2-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	GCCCCCACCTCCCTGGGCCCC	0.622													8	38					0	0	0.006214	0	0
CD33	945	broad.mit.edu	37	19	51738413	51738413	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:51738413G>A	uc002pwa.2	+	5	787	c.747G>A	c.(745-747)GGG>GGA	p.G249G	CD33_uc010eos.1_Silent_p.G249G|CD33_uc010eot.1_Silent_p.G122G|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	249	Extracellular (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	TGTCTGCAGGGAAACAAGAGA	0.483													6	51					0	0	0.003080	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51957508	51957508	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:51957508C>T	uc002pwt.2	-	6	1277	c.1210G>A	c.(1210-1212)GAA>AAA	p.E404K	SIGLEC8_uc010yda.1_Missense_Mutation_p.E295K|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Missense_Mutation_p.E311K	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	404	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TTTGCATCTTCCATGCCTGTA	0.597													11	70					0	0	0.010729	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986373	51986373	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:51986373C>T	uc002pwv.1	+	5	959	c.959C>T	c.(958-960)TCC>TTC	p.S320F		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	320	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		ATCTGCTATTCCTTCCTGGAT	0.522													36	91					0	0	0.008740	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52003401	52003401	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:52003401C>T	uc002pwx.1	-	2	637	c.581G>A	c.(580-582)GGG>GAG	p.G194E	SIGLEC12_uc002pww.1_Missense_Mutation_p.G76E|SIGLEC12_uc010eoy.1_Intron	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	194	Ig-like V-type 2.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TATATCGGCCCCTTCCTTGAA	0.547													13	81					0	0	0.002450	0	0
FPR3	2359	broad.mit.edu	37	19	52327053	52327053	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:52327053G>A	uc002pxt.1	+	2	236	c.52G>A	c.(52-54)GAG>AAG	p.E18K		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	18	Extracellular (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						GGTGCTCCCTGAGCCTGCTGG	0.527													11	36					0	0	0.013537	0	0
FPR3	2359	broad.mit.edu	37	19	52327944	52327944	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:52327944C>T	uc002pxt.1	+	2	1127	c.943C>T	c.(943-945)CGC>TGC	p.R315C		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	315	Cytoplasmic (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						AAGACTGATTCGCTCTTTGCC	0.507													7	58					0	0	0.003080	0	0
ZNF610	162963	broad.mit.edu	37	19	52857608	52857608	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:52857608G>A	uc002pyx.3	+	5	701	c.295G>A	c.(295-297)GAA>AAA	p.E99K	ZNF610_uc002pyy.3_Missense_Mutation_p.E99K|ZNF610_uc002pyz.3_Intron|ZNF610_uc002pza.2_Missense_Mutation_p.E99K	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		AGATGGAAGGGAATGTGTCAG	0.338													5	17					0	0	0.001168	0	0
ZNF808	388558	broad.mit.edu	37	19	53067586	53067586	+	RNA	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:53067586T>G	uc002pzq.2	+	4		c.4098T>G						Q8N4W9	ZN808_HUMAN	Homo sapiens zinc finger protein 808, mRNA (cDNA clone IMAGE:3542548), complete cds.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TTGGACATGTTTTATTGGGAA	0.358													4	12					0	0	0.009096	0	0
ZNF600	162966	broad.mit.edu	37	19	53268876	53268876	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:53268876G>A	uc002qab.3	-	3	2419	c.2133C>T	c.(2131-2133)CAC>CAT	p.H711H		NM_198457	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	711	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		CTGCCTGATGGTGAATAAGTG	0.398													7	61					0	0	0.003080	0	0
ZNF160	90338	broad.mit.edu	37	19	53573069	53573069	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:53573069G>A	uc010eqk.2	-	7	1134	c.718C>T	c.(718-720)CAT>TAT	p.H240Y	ZNF160_uc002qaq.3_Missense_Mutation_p.H240Y|ZNF160_uc002qar.3_Missense_Mutation_p.H240Y	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	240					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		AATGAAAAATGGTTAAGTTCA	0.378													26	53					0	0	0.004656	0	0
VN1R4	317703	broad.mit.edu	37	19	53770583	53770583	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:53770583C>T	uc010ydu.1	-	1	336	c.336G>A	c.(334-336)AGG>AGA	p.R112R		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	112	Cytoplasmic (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.00294)		ACCTGGATTTCCTGGAGCTGA	0.498										HNSCC(26;0.072)			4	17					0	0	0.000602	0	0
ZNF761	388561	broad.mit.edu	37	19	53958887	53958887	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:53958887C>T	uc010eqp.2	+	7	1584	c.1126C>T	c.(1126-1128)CAT>TAT	p.H376Y	ZNF761_uc010ydy.1_Missense_Mutation_p.H322Y|ZNF761_uc002qbt.1_Missense_Mutation_p.H322Y	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	376	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TCATAGACTTCATACTGGAGA	0.433													21	68					0	0	0.014323	0	0
MIR498	574460	broad.mit.edu	37	19	54177496	54177496	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:54177496G>A	hsa-mir-498|MI0003142	+			c.46G>A			MIR520E_hsa-mir-520e|MI0003143_5'Flank																	0						TCAAGCCAGGGGGCGTTTTTC	0.453													16	44					0	0	0.004007	0	0
MIR518F	574472	broad.mit.edu	37	19	54203293	54203293	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:54203293G>A	hsa-mir-518f|MI0003154	+			c.25G>A			MIR520B_hsa-mir-520b|MI0003155_5'Flank|MIR518B_hsa-mir-518b|MI0003156_5'Flank																	0						CCTCTAGAGGGAAGCACTTTC	0.383													5	51					0	0	0.001168	0	0
NLRP12	91662	broad.mit.edu	37	19	54310786	54310786	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:54310786C>T	uc002qch.3	-	4	2426	c.2206G>A	c.(2206-2208)GGA>AGA	p.G736R	NLRP12_uc010eqw.2_5'UTR|NLRP12_uc002qci.3_Missense_Mutation_p.G736R|NLRP12_uc002qcj.3_Missense_Mutation_p.G737R|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.G737R	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	736					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TGTCTGAGTCCTTGACAGAGC	0.587													4	10					0	0	0.009096	0	0
CACNG6	59285	broad.mit.edu	37	19	54515331	54515331	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:54515331G>A	uc002qct.2	+	4	1261	c.671G>A	c.(670-672)GGC>GAC	p.G224D	CACNG6_uc002qcu.2_Missense_Mutation_p.G178D|CACNG6_uc002qcv.2_Missense_Mutation_p.G153D	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	224	Helical; (Potential).					voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		CTGGGCTGCGGCGTGGGGGCC	0.706													14	28					0	0	0.001855	0	0
PRPF31	26121	broad.mit.edu	37	19	54627880	54627880	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:54627880G>T	uc002qdh.2	+	8	1096	c.700G>T	c.(700-702)GTG>TTG	p.V234L	PRPF31_uc010yek.1_Missense_Mutation_p.V234L	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	234	Nop.				assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CACCGCAGGTGTGGCCGGCGG	0.657													8	41					3.86212e-05	4.16571e-05	0.008291	1	0
LAIR2	3904	broad.mit.edu	37	19	55019160	55019160	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55019160G>A	uc002qgc.2	+	3	247	c.125G>A	c.(124-126)GGG>GAG	p.G42E	LAIR2_uc002qga.1_RNA|LAIR2_uc002qgb.1_RNA|LAIR2_uc002qgd.2_Missense_Mutation_p.G42E|LAIR2_uc010erl.2_Missense_Mutation_p.G42E	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like	42	Ig-like C2-type.					extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		ATCTCCCCGGGGAGCCATGTG	0.542													13	86					0	0	0.002450	0	0
LILRA2	11027	broad.mit.edu	37	19	55086440	55086440	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55086440G>A	uc002qgg.3	+	4	684	c.595G>A	c.(595-597)GAC>AAC	p.D199N	LILRA2_uc010ern.2_Missense_Mutation_p.D199N|LILRA2_uc002qgf.2_Missense_Mutation_p.D199N|LILRA2_uc010yfe.1_Missense_Mutation_p.D199N|LILRA2_uc010yff.1_Missense_Mutation_p.D187N|LILRA2_uc010ero.2_Missense_Mutation_p.D187N|LILRA2_uc010yfg.1_Missense_Mutation_p.D199N	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	199	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CTATGCTTATGACTCGAACTC	0.577													8	87					0	0	0.006214	0	0
LILRA1	11024	broad.mit.edu	37	19	55110717	55110717	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55110717C>T	uc002qgh.1	+	8	1460	c.1278C>T	c.(1276-1278)CTC>CTT	p.L426L	LILRA1_uc010yfh.1_Silent_p.L426L	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	426	Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CTGAGACCCTCAGCCCACCAC	0.453													4	27					0	0	0.009096	0	0
LILRB1	10859	broad.mit.edu	37	19	55142543	55142543	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55142543G>A	uc002qgj.2	+	3	359	c.19G>A	c.(19-21)GTC>ATC	p.V7I	LILRB1_uc010erp.1_Missense_Mutation_p.V24I|LILRB1_uc002qgl.2_Missense_Mutation_p.V7I|LILRB1_uc002qgk.2_Missense_Mutation_p.V7I|LILRB1_uc002qgm.2_Missense_Mutation_p.V7I|LILRB1_uc010erq.2_Missense_Mutation_p.V7I|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	7					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CATCCTCACGGTCCTGATCTG	0.587										HNSCC(37;0.09)			17	40					0	0	0.012319	0	0
LILRB1	10859	broad.mit.edu	37	19	55144767	55144767	+	Missense_Mutation	SNP	C	T	T	rs148543880		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55144767C>T	uc002qgj.2	+	8	1599	c.1259C>T	c.(1258-1260)TCA>TTA	p.S420L	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.S420L|LILRB1_uc002qgk.2_Missense_Mutation_p.S420L|LILRB1_uc002qgm.2_Missense_Mutation_p.S420L|LILRB1_uc010erq.2_Missense_Mutation_p.S420L|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	420	Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity	p.S420L(1)		large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CTCGTGGTCTCAGGTGGGGGC	0.637										HNSCC(37;0.09)			16	40					0	0	0.006122	0	0
LILRP2	79166	broad.mit.edu	37	19	55221625	55221625	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55221625C>T	uc002qgs.1	+	1		c.2025C>T			LILRP2_uc002qgt.1_RNA	NR_003061				Homo sapiens leukocyte immunoglobulin-like receptor pseudogene 2 (LILRP2), non-coding RNA.												0						CCCTGAGCATCCTGATCGCAG	0.677													4	21					0	0	0.001168	0	0
KIR2DL3	3804	broad.mit.edu	37	19	55263938	55263938	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55263938C>T	uc002qgv.2	+	8	1011	c.993C>T	c.(991-993)ATC>ATT	p.I331I	KIR2DS4_uc010yfj.1_5'Flank|KIR2DL3_uc002qgx.2_Silent_p.I331I|KIR2DL3_uc002qgy.2_Silent_p.I233I|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron|KIR3DP1_uc010yfi.1_5'Flank	NM_015868	NP_056952	P43628	KI2L3_HUMAN	killer cell immunoglobulin-like receptor, two	331	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	antigen binding|protein binding|receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		CAGATATCATCGTGTACACGG	0.507													67	166					0	0	0.014410	0	0
FCAR	2204	broad.mit.edu	37	19	55399440	55399440	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55399440C>T	uc002qhr.1	+	4	625	c.428C>T	c.(427-429)TCC>TTC	p.S143F	FCAR_uc002qhq.2_Missense_Mutation_p.S143F|FCAR_uc002qhs.1_Intron|FCAR_uc002qht.1_Missense_Mutation_p.S116F|FCAR_uc010esi.1_Intron|FCAR_uc002qhu.1_Intron|FCAR_uc002qhv.1_Missense_Mutation_p.S143F|FCAR_uc002qhw.1_Missense_Mutation_p.S131F|FCAR_uc002qhx.1_Intron|FCAR_uc002qhy.1_Missense_Mutation_p.S131F|FCAR_uc002qhz.1_Missense_Mutation_p.S131F|FCAR_uc002qia.1_Missense_Mutation_p.S34F	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	143	Ig-like C2-type 2.|Extracellular (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		GAGAATATTTCCCTCACGTGC	0.507													13	32					0	0	0.003163	0	0
NLRP2	55655	broad.mit.edu	37	19	55494640	55494640	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55494640G>A	uc002qij.2	+	6	1660	c.1574G>A	c.(1573-1575)AGG>AAG	p.R525K	NLRP2_uc010yfp.1_Missense_Mutation_p.R502K|NLRP2_uc010esn.2_Missense_Mutation_p.R501K|NLRP2_uc010eso.2_Missense_Mutation_p.R522K|NLRP2_uc010esp.2_Missense_Mutation_p.R503K	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	525	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GAAGAGGATAGGGACGGCCAC	0.547													8	57					0	0	0.004482	0	0
NLRP2	55655	broad.mit.edu	37	19	55501907	55501907	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55501907G>A	uc002qij.2	+	10	2661	c.2575G>A	c.(2575-2577)GAC>AAC	p.D859N	NLRP2_uc010yfp.1_Missense_Mutation_p.D836N|NLRP2_uc010esn.2_Missense_Mutation_p.D835N|NLRP2_uc010eso.2_Missense_Mutation_p.D856N|NLRP2_uc010esp.2_Missense_Mutation_p.D837N	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	859	LRR 2.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CAATTGCAAGGACCTTGCTGC	0.507													4	45					0	0	0.009096	0	0
BRSK1	84446	broad.mit.edu	37	19	55820096	55820097	+	Splice_Site	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:55820096_55820097GG>AA	uc002qkg.2	+	18	2456	c.2179_splice	c.e18+1	p.D727_splice	BRSK1_uc002qkf.2_Splice_Site_p.D743_splice|BRSK1_uc002qkh.2_Splice_Site_p.D422_splice	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1						establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GGCCCTggcaggtgggtggtgg	0.302													4	7					0	0	0.004672	0	0
EPN1	29924	broad.mit.edu	37	19	56206615	56206615	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:56206615C>T	uc002qlw.2	+	11	1966	c.1624C>T	c.(1624-1626)CCT>TCT	p.P542S	EPN1_uc002qlv.2_Missense_Mutation_p.P516S|EPN1_uc010etd.2_Missense_Mutation_p.P541S|EPN1_uc002qlx.2_Missense_Mutation_p.P628S	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	542	Ala/Gly/Pro-rich.|3 X 3 AA repeats of N-P-F.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		GCCTCCCGTCCCTGGAGCGCC	0.602													3	9					0	0	0.009096	0	0
NLRP4	147945	broad.mit.edu	37	19	56369483	56369483	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:56369483G>A	uc002qmd.3	+	3	1146	c.724G>A	c.(724-726)GAA>AAA	p.E242K	NLRP4_uc002qmf.2_Missense_Mutation_p.E167K|NLRP4_uc010etf.2_Missense_Mutation_p.E73K	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	242	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CGGCTTGAACGAACCCGATTC	0.572													10	60					0	0	0.006214	0	0
NLRP4	147945	broad.mit.edu	37	19	56370434	56370434	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:56370434G>A	uc002qmd.3	+	3	2097	c.1675G>A	c.(1675-1677)GAA>AAA	p.E559K	NLRP4_uc002qmf.2_Missense_Mutation_p.E484K|NLRP4_uc010etf.2_Missense_Mutation_p.E390K	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	559							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CTGTCTCTTTGAAATGCAGGA	0.473													18	38					0	0	0.006122	0	0
NLRP13	126204	broad.mit.edu	37	19	56410206	56410206	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:56410206C>T	uc010ygg.1	-	10	2912	c.2887G>A	c.(2887-2889)GAT>AAT	p.D963N		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	963	LRR 6.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TCCTGAAGATCATTTTCTCCC	0.463													24	54					0	0	0.002780	0	0
NLRP8	126205	broad.mit.edu	37	19	56487502	56487502	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:56487502G>A	uc002qmh.2	+	8	2780	c.2709G>A	c.(2707-2709)CTG>CTA	p.L903L	NLRP8_uc010etg.2_Silent_p.L884L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	903						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TTTGCAGACTGAGAAAGTGTG	0.274													22	32					0	0	0.003330	0	0
GALP	85569	broad.mit.edu	37	19	56694533	56694533	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:56694533C>T	uc002qmo.1	+	5	329	c.247C>T	c.(247-249)CCC>TCC	p.P83S	GALP_uc010eti.2_3'UTR	NM_033106	NP_149097	Q9UBC7	GALP_HUMAN	galanin-like peptide isoform 1 precursor	83					neuropeptide signaling pathway	extracellular region	hormone activity				0		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		CCCTCCACAGCCCTCCAAGAG	0.368													9	30					0	0	0.010729	0	0
ZNF667	63934	broad.mit.edu	37	19	56973722	56973722	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:56973722C>T	uc002qnd.2	-	2	180	c.18G>A	c.(16-18)GGG>GGA	p.G6G	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_Silent_p.G6G|ZNF667_uc010etm.2_5'UTR	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	6					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		ATTTGGATTTCCCCCGTGCAG	0.532													25	93					0	0	0.004656	0	0
ZNF470	388566	broad.mit.edu	37	19	57086037	57086037	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:57086037C>T	uc002qnl.3	+	5	894	c.218C>T	c.(217-219)TCC>TTC	p.S73F	ZNF470_uc010etn.2_RNA	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	73	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		GATGTGATCTCCTTACTGGAG	0.413													15	22					0	0	0.004990	0	0
PEG3	5178	broad.mit.edu	37	19	57326320	57326320	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:57326320C>T	uc002qnu.2	-	7	3841	c.3490G>A	c.(3490-3492)GAA>AAA	p.E1164K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E1135K|PEG3_uc002qnv.2_Missense_Mutation_p.E1164K|PEG3_uc002qnw.2_Missense_Mutation_p.E1040K|PEG3_uc002qnx.2_Missense_Mutation_p.E1038K|PEG3_uc010etr.2_Missense_Mutation_p.E1164K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1164	C2H2-type 7.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTTGGACATTCATACAGCTGC	0.448													17	82					0	0	0.004990	0	0
PEG3	5178	broad.mit.edu	37	19	57326512	57326512	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:57326512C>T	uc002qnu.2	-	7	3649	c.3298G>A	c.(3298-3300)GAT>AAT	p.D1100N	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.D1071N|PEG3_uc002qnv.2_Missense_Mutation_p.D1100N|PEG3_uc002qnw.2_Missense_Mutation_p.D976N|PEG3_uc002qnx.2_Missense_Mutation_p.D974N|PEG3_uc010etr.2_Missense_Mutation_p.D1100N	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1100					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCAGGGTCATCCTTCTGAGGG	0.512													17	64					0	0	0.006122	0	0
DUXA	503835	broad.mit.edu	37	19	57672125	57672125	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:57672125G>A	uc002qoa.1	-	2	111	c.66C>T	c.(64-66)TTC>TTT	p.F22F		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	22	Homeobox 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		GTTCTTCTGTGAATTTTGTGC	0.338													25	56					0	0	0.003330	0	0
AURKC	6795	broad.mit.edu	37	19	57743922	57743922	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:57743922C>T	uc002qoe.2	+	4	498	c.309C>T	c.(307-309)ATC>ATT	p.I103I	AURKC_uc002qoc.2_Silent_p.I84I|AURKC_uc002qod.2_Silent_p.I69I|AURKC_uc010etv.2_Silent_p.I100I	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	103	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		ACCCCAATATCCTGCGCCTGT	0.493													7	62					0	0	0.001984	0	0
ZNF419	79744	broad.mit.edu	37	19	58003528	58003528	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:58003528G>A	uc002qov.2	+	4	487	c.247G>A	c.(247-249)GAG>AAG	p.E83K	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Missense_Mutation_p.E84K|ZNF419_uc010etz.1_Missense_Mutation_p.E71K|ZNF419_uc010eua.1_Missense_Mutation_p.E70K|ZNF419_uc002qow.2_Intron|ZNF419_uc010eub.1_Intron|ZNF419_uc010euc.1_Intron	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	83	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		GGAGTCATGGGAGGAGCCCTT	0.512													4	44					0	0	0.003080	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58190186	58190186	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:58190186C>T	uc002qpu.2	+	5	1912	c.1215C>T	c.(1213-1215)TAC>TAT	p.Y405Y		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	405	C2H2-type 4.				telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGACAAGCTACCGCCAGTCAT	0.478													21	75					0	0	0.012319	0	0
ZNF418	147686	broad.mit.edu	37	19	58441905	58441905	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:58441905T>A	uc002qqs.1	-	3	316	c.24A>T	c.(22-24)GAA>GAT	p.E8D	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Intron	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	8	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CAGCCACATCTTCAAATGCCA	0.507													7	60					0	0	0.004482	0	0
ZNF606	80095	broad.mit.edu	37	19	58490285	58490285	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:58490285C>T	uc002qqw.2	-	7	2381	c.1763G>A	c.(1762-1764)AGA>AAA	p.R588K	ZNF606_uc010yhp.1_Missense_Mutation_p.R498K	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	588	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		CGTGTGAGTTCTCTGATGGGC	0.408													5	68					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	2	905523	905523	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:905523C>T	uc010ewg.2	-	1		c.60G>A			uc010ewh.1_Missense_Mutation_p.M141I					Homo sapiens cDNA FLJ46162 fis, clone TESTI4002520.																		TCTGGTGTTTCATTTCCTCCC	0.607													6	152					0	0	0.006214	0	0
TPO	7173	broad.mit.edu	37	2	1488624	1488624	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:1488624G>A	uc002qww.2	+	9	1686	c.1595G>A	c.(1594-1596)GGA>GAA	p.G532E	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.G532E|TPO_uc002qwr.2_Missense_Mutation_p.G532E|TPO_uc002qwx.2_Missense_Mutation_p.G532E|TPO_uc010yio.1_Missense_Mutation_p.G359E|TPO_uc010yip.1_Missense_Mutation_p.G532E|TPO_uc002qwy.1_5'UTR|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	532	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TTACTCCGTGGAGGTGAGTGA	0.478													4	28					0	0	0.000602	0	0
KIDINS220	57498	broad.mit.edu	37	2	8872048	8872048	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:8872048G>A	uc002qzc.2	-	30	4300	c.4118C>T	c.(4117-4119)TCA>TTA	p.S1373L	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Missense_Mutation_p.S1274L|KIDINS220_uc002qzb.2_Missense_Mutation_p.S227L	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1373	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AGTAAGCTTTGAAATTTCAAT	0.413													6	66					0	0	0.001984	0	0
KCNF1	3754	broad.mit.edu	37	2	11053632	11053632	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:11053632C>T	uc002rax.2	+	1	1570	c.1080C>T	c.(1078-1080)TCC>TCT	p.S360S		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	360						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		TCCCCCAGTCCTTCTGGTGGG	0.582													4	29					0	0	0.009096	0	0
NT5C1B	93034	broad.mit.edu	37	2	18770707	18770707	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:18770707T>C	uc002rcz.2	-	1	132	c.28A>G	c.(28-30)AAG>GAG	p.K10E	NT5C1B_uc002rcy.2_Missense_Mutation_p.K10E|NT5C1B_uc010exr.2_Missense_Mutation_p.K10E|NT5C1B_uc010yju.1_Intron|NT5C1B_uc002rda.2_Missense_Mutation_p.K10E|NT5C1B_uc010yjv.1_Missense_Mutation_p.K10E|NT5C1B_uc010yjw.1_Missense_Mutation_p.K10E|NT5C1B_uc010exs.2_Missense_Mutation_p.K10E	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	10					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TCACTCACCTTTTTCTGTTTG	0.408													3	47					0	0	0.009096	0	0
DNMT3A	1788	broad.mit.edu	37	2	25467048	25467048	+	Silent	SNP	G	A	A	rs147260180		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:25467048G>A	uc002rgc.2	-	15	2084	c.1827C>T	c.(1825-1827)TTC>TTT	p.F609F	DNMT3A_uc002rgd.2_Silent_p.F609F|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.F420F	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	609	ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTTATTAGCGAAGAACATCT	0.627			Mis|F|N|S		AML								9	42					0	0	0.008291	0	0
HADHB	3032	broad.mit.edu	37	2	26501645	26501645	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:26501645C>T	uc002rgz.2	+	8	857	c.606C>T	c.(604-606)TTC>TTT	p.F202F	HADHB_uc010ykv.1_Silent_p.F180F|HADHB_uc010ykw.1_Silent_p.F187F|HADHB_uc002rha.2_Intron|HADHB_uc010ykx.1_Silent_p.F128F	NM_000183	NP_000174	P55084	ECHB_HUMAN	mitochondrial trifunctional protein, beta	202					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTCTAAATTCCGATTTAATT	0.443													8	56					0	0	0.004482	0	0
OTOF	9381	broad.mit.edu	37	2	26691294	26691294	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:26691294C>T	uc002rhk.2	-	33	4199	c.4072G>A	c.(4072-4074)GAA>AAA	p.E1358K	OTOF_uc010yla.1_Missense_Mutation_p.E88K|OTOF_uc002rhh.2_Missense_Mutation_p.E591K|OTOF_uc002rhi.2_Missense_Mutation_p.E668K|OTOF_uc002rhj.2_Missense_Mutation_p.E591K	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1358	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGTCCACTTCCTCCTTCTCC	0.567													6	46					0	0	0.004482	0	0
C2orf53	339779	broad.mit.edu	37	2	27360809	27360809	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:27360809G>A	uc002rjb.2	-	3	969	c.389C>T	c.(388-390)CCC>CTC	p.P130L		NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	130	Pro-rich.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					aggctgggagggagaaaagga	0.159													5	14					0	0	0.000602	0	0
SLC5A6	8884	broad.mit.edu	37	2	27427456	27427456	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:27427456G>A	uc002rjd.2	-	9	1269	c.878C>T	c.(877-879)TCC>TTC	p.S293F	SLC5A6_uc010eyv.1_Missense_Mutation_p.S293F	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	293					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	TGCATAACAGGAGCTGCAAAA	0.572													5	36					0	0	0.000602	0	0
C2orf16	84226	broad.mit.edu	37	2	27799475	27799475	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:27799475A>G	uc002rkz.3	+	1	87	c.36A>G	c.(34-36)ATA>ATG	p.I12M		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	12										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					AGCAAGGTATAAATTATCAAG	0.453													8	18					0	0	0.008291	0	0
C2orf16	84226	broad.mit.edu	37	2	27799493	27799493	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:27799493T>C	uc002rkz.3	+	1	105	c.54T>C	c.(52-54)ACT>ACC	p.T18T		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	18										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					AAGAGTTGACTTCAGGATGGC	0.433													8	19					0	0	0.004482	0	0
PLB1	151056	broad.mit.edu	37	2	28828750	28828750	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:28828750C>T	uc002rmb.1	+	42	2992	c.2992C>T	c.(2992-2994)CCA>TCA	p.P998S	PLB1_uc010ezj.1_Missense_Mutation_p.P987S|PLB1_uc002rme.1_Intron|PLB1_uc002rmf.1_RNA	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	998	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|3.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CTTCTTTGCCCCAGACTGCAT	0.527													12	150					0	0	0.001855	0	0
CLIP4	79745	broad.mit.edu	37	2	29356672	29356672	+	Silent	SNP	G	A	A	rs150045383		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:29356672G>A	uc002rmv.2	+	5	758	c.519G>A	c.(517-519)TCG>TCA	p.S173S	CLIP4_uc002rmu.2_Silent_p.S173S|CLIP4_uc010ezm.1_Silent_p.S173S|CLIP4_uc002rmw.2_RNA|CLIP4_uc010ymn.1_Silent_p.S155S	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	173	ANK 2.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					TGAAAACATCGAAACCAAAAG	0.328													5	36					0	0	0.001168	0	0
ALK	238	broad.mit.edu	37	2	29543651	29543651	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:29543651C>T	uc002rmy.2	-	7	2419	c.1512G>A	c.(1510-1512)AGG>AGA	p.R504R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	504	MAM 2.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCTTTAGGGTCCTGACCTGCC	0.542			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				16	69					0	0	0.008871	0	0
EHD3	30845	broad.mit.edu	37	2	31467274	31467274	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:31467274C>T	uc002rnu.2	+	2	970	c.362C>T	c.(361-363)CCC>CTC	p.P121L	EHD3_uc010ymt.1_Missense_Mutation_p.P121L	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	121					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					CCCAAGAAACCCTTCAGGAAA	0.547													6	32					0	0	0.001984	0	0
EHD3	30845	broad.mit.edu	37	2	31489123	31489123	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:31489123C>T	uc002rnu.2	+	6	1769	c.1161C>T	c.(1159-1161)GCC>GCT	p.A387A	EHD3_uc010ymt.1_3'UTR	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	387					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					ACATGCTGGCCCATGACATTG	0.627													5	38					0	0	0.000602	0	0
YIPF4	84272	broad.mit.edu	37	2	32523369	32523369	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:32523369C>T	uc002rok.2	+	4	739	c.472C>T	c.(472-474)CTT>TTT	p.L158F		NM_032312	NP_115688	Q9BSR8	YIPF4_HUMAN	Yip1 domain family, member 4	158	Helical; (Potential).					endoplasmic reticulum|integral to membrane	protein binding				0	Acute lymphoblastic leukemia(172;0.155)					GGCCAGAGTTCTTGGTGGAGA	0.313													3	38					0	0	0.004672	0	0
CRIM1	51232	broad.mit.edu	37	2	36740748	36740748	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:36740748C>T	uc002rpd.2	+	11	1869	c.1830C>T	c.(1828-1830)ACC>ACT	p.T610T		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	610	VWFC 3.|Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				CTTGTCTCACCGTGGATGGTC	0.552													6	79					0	0	0.003080	0	0
SULT6B1	391365	broad.mit.edu	37	2	37414600	37414600	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:37414600C>T	uc002rpu.2	-	2	117	c.96G>A	c.(94-96)TGG>TGA	p.W32*	SULT6B1_uc010yni.1_RNA	NM_001032377	NP_001027549	Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member	70	PAPS (By similarity).					cytoplasm	sulfotransferase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(82;0.248)				TGTGGAGAATCCAGTTTGAAC	0.294													4	17					0	0	0.009096	0	0
C2orf56	55471	broad.mit.edu	37	2	37468928	37468929	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:37468928_37468929CC>TT	uc002rqa.3	+	5	691_692	c.616_617CC>TT	c.(616-618)CCA>TTA	p.P206L	C2orf56_uc010ynj.1_RNA|C2orf56_uc002rqc.3_Intron|C2orf56_uc010ynk.1_Intron|C2orf56_uc010ynl.1_Missense_Mutation_p.P179L|C2orf56_uc010fah.2_Intron	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	206					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				GCACGATGTTCCAAAAGGTAAT	0.396													6	31					0	0	0.004672	0	0
PRKD3	23683	broad.mit.edu	37	2	37507065	37507065	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:37507065G>A	uc002rqd.2	-	7	1551	c.996C>T	c.(994-996)TCC>TCT	p.S332S	PRKD3_uc002rqe.1_5'Flank|PRKD3_uc002rqf.1_Silent_p.S332S	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	332					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				TTCCCAGACTGGAAGGTTCTG	0.294													5	20					0	0	0.000602	0	0
Unknown	0	broad.mit.edu	37	2	38709723	38709723	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:38709723G>A	uc002rqu.1	+	2	613	c.546G>A	c.(544-546)CGG>CGA	p.R182R						SubName: Full=RPLP0 protein;																		ATCATCAACGGGTACAAACGA	0.483													4	42					0	0	0.009096	0	0
TMEM178	130733	broad.mit.edu	37	2	39944332	39944332	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:39944332C>T	uc002rrt.2	+	4	860	c.835C>T	c.(835-837)CCG>TCG	p.P279S	TMEM178_uc010fam.1_Missense_Mutation_p.P233S	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	279	Cytoplasmic (Potential).					integral to membrane					0		all_hematologic(82;0.248)				CATCGCTTATCCGTTTATTAG	0.537													10	66					0	0	0.006214	0	0
SLC8A1	6546	broad.mit.edu	37	2	40387911	40387911	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:40387911T>C	uc002rrx.2	-	8	2287	c.2263A>G	c.(2263-2265)AGT>GGT	p.S755G	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Missense_Mutation_p.S750G|SLC8A1_uc002rrz.2_Missense_Mutation_p.S742G|SLC8A1_uc002rsa.2_Missense_Mutation_p.S719G|SLC8A1_uc002rsd.3_Missense_Mutation_p.S719G	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	755	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCACCAGCACTGACAGTGATA	0.428													9	69					0	0	0.008291	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43927739	43927739	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:43927739C>T	uc010yny.1	+	8	1725	c.1642C>T	c.(1642-1644)CCT>TCT	p.P548S	PLEKHH2_uc002rte.3_Missense_Mutation_p.P548S|PLEKHH2_uc002rtf.3_Missense_Mutation_p.P547S	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	548						cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCACCGTTTTCCTTCTTGGGT	0.363													23	225					0	0	0.003330	0	0
EFEMP1	2202	broad.mit.edu	37	2	56149495	56149495	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:56149495C>T	uc002rzh.2	-	2	411	c.81G>A	c.(79-81)ACG>ACA	p.T27T	EFEMP1_uc002rzi.2_Silent_p.T27T|EFEMP1_uc002rzj.2_Silent_p.T27T|EFEMP1_uc010ypc.1_5'UTR	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	27	EGF-like 1; atypical.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CACCCCTTACCGTGTACGTGA	0.443													9	71					0	0	0.006214	0	0
EHBP1	23301	broad.mit.edu	37	2	63101536	63101536	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:63101536C>T	uc002sby.2	+	11	1641	c.1159C>T	c.(1159-1161)CCT>TCT	p.P387S	EHBP1_uc010fcp.2_Missense_Mutation_p.P352S|EHBP1_uc002sbz.2_Missense_Mutation_p.P352S|EHBP1_uc002scb.2_Missense_Mutation_p.P352S	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	387						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TTTGGTAAATCCTGTTCAAGA	0.363									Hereditary_Prostate_Cancer				8	60					0	0	0.003080	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043970	71043970	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:71043970C>T	uc002shf.2	-	4	620	c.543G>A	c.(541-543)CAG>CAA	p.Q181Q	CLEC4F_uc010yqv.1_Silent_p.Q181Q	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	181	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						CCTTGAGCCTCTGGATCTCAG	0.443													7	31					0	0	0.003080	0	0
ZNF638	27332	broad.mit.edu	37	2	71576268	71576268	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:71576268C>T	uc002shx.2	+	2	503	c.184C>T	c.(184-186)CAG>TAG	p.Q62*	ZNF638_uc010fec.2_Nonsense_Mutation_p.Q168*|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Nonsense_Mutation_p.Q62*|ZNF638_uc002shy.2_Nonsense_Mutation_p.Q62*|ZNF638_uc002shz.2_Nonsense_Mutation_p.Q62*|ZNF638_uc002sia.2_Nonsense_Mutation_p.Q62*|ZNF638_uc002sib.1_Nonsense_Mutation_p.Q62*	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	62					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TGAATCTTATCAGAACATGGG	0.443													8	41					0	0	0.004482	0	0
DCTN1	1639	broad.mit.edu	37	2	74594007	74594007	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:74594007G>A	uc002skx.2	-	21	2680	c.2369C>T	c.(2368-2370)TCA>TTA	p.S790L	DCTN1_uc002skt.1_5'Flank|DCTN1_uc002skv.2_Missense_Mutation_p.S656L|DCTN1_uc002sku.2_Missense_Mutation_p.S656L|DCTN1_uc002skw.1_Missense_Mutation_p.S766L|DCTN1_uc010ffd.2_Missense_Mutation_p.S770L|DCTN1_uc002sky.2_Missense_Mutation_p.S753L	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	790					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						GTCACTGCATGAAGTTTCCAG	0.532													6	46					0	0	0.001984	0	0
DQX1	165545	broad.mit.edu	37	2	74751156	74751156	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:74751156C>T	uc010yrw.1	-	4	875	c.710G>A	c.(709-711)TGG>TAG	p.W237*	DQX1_uc002smc.2_5'Flank	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	237						nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						GATGGTGTCCCAGTAGATGGG	0.557													9	37					0	0	0.010729	0	0
SEMA4F	10505	broad.mit.edu	37	2	74883760	74883761	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:74883760_74883761GG>AA	uc002sna.1	+	2	356_357	c.245_246GG>AA	c.(244-246)CGG>CAA	p.R82Q	SEMA4F_uc010ysb.1_Missense_Mutation_p.R82Q|SEMA4F_uc010ffq.1_Missense_Mutation_p.R82Q|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Missense_Mutation_p.R82Q	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	82	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GTTGGCGCCCGGGACACCATCT	0.559													5	57					0	0	0.004672	0	0
SEMA4F	10505	broad.mit.edu	37	2	74885033	74885033	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:74885033C>T	uc002sna.1	+	4	522	c.411C>T	c.(409-411)CTC>CTT	p.L137L	SEMA4F_uc010ysb.1_Intron|SEMA4F_uc010ffq.1_Intron|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_Intron|SEMA4F_uc002snc.1_Intron	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	137	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CCTCTCACCTCCTCACTTGTG	0.532													13	75					0	0	0.002450	0	0
SEMA4F	10505	broad.mit.edu	37	2	74901796	74901796	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:74901796T>G	uc002sna.1	+	8	1105	c.994T>G	c.(994-996)TCC>GCC	p.S332A	SEMA4F_uc010ffq.1_Missense_Mutation_p.S299A|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Missense_Mutation_p.S177A	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	332	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CATCTTTTCTTCCCAGTGGTG	0.577													7	82					0	0	0.001984	0	0
SFTPB	6439	broad.mit.edu	37	2	85894825	85894825	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:85894825C>T	uc002sqh.2	-	2	178	c.172G>A	c.(172-174)GAA>AAA	p.E58K	SFTPB_uc002sqi.2_Missense_Mutation_p.E70K|SFTPB_uc002sqj.2_Missense_Mutation_p.E58K	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	58	Saposin A-type.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						CCCCAGACTTCCTGTAGGCAA	0.607													13	118					0	0	0.003163	0	0
POLR1A	25885	broad.mit.edu	37	2	86292422	86292422	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:86292422G>A	uc002sqs.2	-	14	2412	c.2033C>T	c.(2032-2034)CCC>CTC	p.P678L	POLR1A_uc010ytb.1_Missense_Mutation_p.P44L	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	678					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						CAGCGGAAAGGGCTTCAGGAT	0.488													6	62					0	0	0.001168	0	0
LOC285074	285074	broad.mit.edu	37	2	87276797	87276797	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:87276797G>A	uc002ssg.1	-	1	893	c.193C>T	c.(193-195)CTT>TTT	p.L65F	RMND5A_uc002srs.3_Intron|LOC285074_uc010fgw.2_Missense_Mutation_p.L26F|LOC285074_uc002ssf.3_Missense_Mutation_p.L26F					SubName: Full=cDNA FLJ10361 fis, clone NT2RM2001256, highly similar to Anaphase-promoting complex subunit 1;												0						GCACTCTGAAGAAGCCTTCGC	0.468													13	39					0	0	0.003163	0	0
FABP1	2168	broad.mit.edu	37	2	88425812	88425812	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:88425812G>A	uc002sst.1	-	2	165	c.123C>T	c.(121-123)ATC>ATT	p.I41I	FABP1_uc002ssu.2_Silent_p.I41I	NM_001443	NP_001434	P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	41					organ morphogenesis						0						CATTCTGCACGATTTCCGACA	0.527													9	175					0	0	0.004482	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88874650	88874650	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:88874650G>A	uc002stc.3	-	13	2553	c.2351C>T	c.(2350-2352)TCC>TTC	p.S784F		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	784	Cytoplasmic (Potential).|Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						AAGTTCAAAGGAGTGCCCCTC	0.458													39	435					0	0	0.004289	0	0
PROM2	150696	broad.mit.edu	37	2	95943131	95943131	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:95943131C>T	uc002suh.1	+	7	925	c.792C>T	c.(790-792)CAC>CAT	p.H264H	PROM2_uc002sui.2_Silent_p.H264H|PROM2_uc002suj.2_5'UTR|PROM2_uc002suk.2_Silent_p.H264H|PROM2_uc002sul.2_5'UTR	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	264	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						TCTCCGTGCACCACCTGCAAA	0.642													5	31					0	0	0.000602	0	0
KCNIP3	30818	broad.mit.edu	37	2	96040071	96040071	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:96040071C>T	uc002sup.2	+	3	324	c.209C>T	c.(208-210)TCC>TTC	p.S70F	KCNIP3_uc002suq.2_Missense_Mutation_p.S44F	NM_013434	NP_038462	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3 isoform 1	70	EF-hand 1; degenerate.				apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			breast(2)|ovary(1)	3				READ - Rectum adenocarcinoma(193;0.13)		CTGGAGCTGTCCACGGTGCGC	0.597													4	37					0	0	0.009096	0	0
VWA3B	200403	broad.mit.edu	37	2	98736213	98736213	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:98736213T>C	uc002syo.2	+	4	793	c.529T>C	c.(529-531)TTC>CTC	p.F177L	VWA3B_uc010yvh.1_Intron|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_5'UTR|VWA3B_uc002sym.2_Missense_Mutation_p.F177L|VWA3B_uc002syn.1_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	177										ovary(3)|large_intestine(2)|skin(1)	6						CATAACCGAGTTCAATATCAT	0.448													7	82					0	0	0.003080	0	0
MGAT4A	11320	broad.mit.edu	37	2	99256428	99256428	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:99256428G>A	uc002sze.2	-	12	1479	c.1165C>T	c.(1165-1167)CAT>TAT	p.H389Y	C2orf64_uc002sza.2_Intron|MGAT4A_uc010yvm.1_Missense_Mutation_p.H261Y|MGAT4A_uc010fil.2_Missense_Mutation_p.H143Y	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	389	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						GGGTTTACATGGATTTTAAGA	0.368													6	31					0	0	0.001168	0	0
REV1	51455	broad.mit.edu	37	2	100055763	100055763	+	Silent	SNP	G	A	A	rs28382881	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:100055763G>A	uc002tad.2	-	6	725	c.513C>T	c.(511-513)ATC>ATT	p.I171I	REV1_uc002tac.2_Silent_p.I171I|REV1_uc002tae.1_Silent_p.I150I	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	171					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						TCTTCTTAACGATGTGATTTC	0.299								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					4	29					0	0	0.009096	0	0
NPAS2	4862	broad.mit.edu	37	2	101611915	101611915	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:101611915C>T	uc002tap.1	+	21	2632	c.2346C>T	c.(2344-2346)TCC>TCT	p.S782S	NPAS2_uc010yvt.1_Silent_p.S847S|NPAS2_uc010fit.1_3'UTR	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	782					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						TACTTCTCTCCACCTACTCAC	0.577													6	92					0	0	0.001168	0	0
MAP4K4	9448	broad.mit.edu	37	2	102441817	102441817	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:102441817G>A	uc002tbg.2	+	5	398	c.343G>A	c.(343-345)GAC>AAC	p.D115N	MAP4K4_uc002tbc.2_Missense_Mutation_p.D115N|MAP4K4_uc002tbd.2_Missense_Mutation_p.D115N|MAP4K4_uc002tbe.2_Missense_Mutation_p.D115N|MAP4K4_uc002tbf.2_Missense_Mutation_p.D115N|MAP4K4_uc010yvy.1_Missense_Mutation_p.D115N|MAP4K4_uc002tbh.2_Missense_Mutation_p.D115N|MAP4K4_uc002tbi.2_Missense_Mutation_p.D115N|MAP4K4_uc010yvz.1_Missense_Mutation_p.D95N|MAP4K4_uc010fiw.1_Intron|MAP4K4_uc002tbj.1_Missense_Mutation_p.D11N	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	115	Protein kinase.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GTCCATTACAGACCTTGTGAA	0.463													4	19					0	0	0.009096	0	0
IL1R2	7850	broad.mit.edu	37	2	102626047	102626047	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:102626047C>T	uc002tbm.2	+	3	320	c.91C>T	c.(91-93)CGT>TGT	p.R31C	IL1R2_uc002tbn.2_Missense_Mutation_p.R31C|IL1R2_uc002tbo.1_Missense_Mutation_p.R31C	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	31	Extracellular (Potential).|Ig-like C2-type 1.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	CTGCCGGTTTCGTGGGAGGCA	0.612													10	95					0	0	0.006214	0	0
IL1R2	7850	broad.mit.edu	37	2	102638677	102638677	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:102638677C>T	uc002tbm.2	+	6	946	c.717C>T	c.(715-717)ATC>ATT	p.I239I	IL1R2_uc002tbn.2_Silent_p.I239I|IL1R2_uc002tbo.1_Silent_p.I239I	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	239	Extracellular (Potential).|Ig-like C2-type 3.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	TTCCTGTGATCATTTCCCCCC	0.483													20	178					0	0	0.014323	0	0
IL1RL1	9173	broad.mit.edu	37	2	102956711	102956711	+	Silent	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:102956711A>C	uc002tbu.1	+	4	697	c.426A>C	c.(424-426)ACA>ACC	p.T142T	IL1RL1_uc010ywa.1_Silent_p.T25T|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Silent_p.T142T	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	142	Ig-like C2-type 2.|Extracellular (Potential).				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						ACAACTGGACAGCACCTCTTG	0.294													5	25					0	0	0.001984	0	0
IL1RL1	9173	broad.mit.edu	37	2	102959823	102959823	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:102959823G>A	uc002tbu.1	+	8	1189	c.918G>A	c.(916-918)CTG>CTA	p.L306L	IL1RL1_uc010ywa.1_Silent_p.L189L|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Silent_p.L306L	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	306	Extracellular (Potential).|Ig-like C2-type 3.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GTCTGGCCCTGAATTTGCATG	0.433													10	74					0	0	0.008291	0	0
IL18RAP	8807	broad.mit.edu	37	2	103063616	103063616	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:103063616G>A	uc002tbx.2	+	10	1643	c.1159G>A	c.(1159-1161)GAA>AAA	p.E387K	IL18RAP_uc010fiz.2_Missense_Mutation_p.E245K	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	387	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						GCACTGGATTGAAATAGTGCT	0.577													8	113					0	0	0.006214	0	0
NCK2	8440	broad.mit.edu	37	2	106471561	106471561	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:106471561C>T	uc002tdg.2	+	3	484	c.42C>T	c.(40-42)ACC>ACT	p.T14T	NCK2_uc002tdh.2_Silent_p.T14T|NCK2_uc002tdi.2_Silent_p.T14T	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	14	SH3 1.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GGGACTACACCGCCCAGCAGG	0.537													4	47					0	0	0.000602	0	0
NCK2	8440	broad.mit.edu	37	2	106498441	106498441	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:106498441C>T	uc002tdg.2	+	4	1326	c.884C>T	c.(883-885)GCC>GTC	p.A295V	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Missense_Mutation_p.A295V	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	295	SH2.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						CGGCACCAGGCCGAGTGCGCC	0.687													4	19					0	0	0.009096	0	0
RGPD3	653489	broad.mit.edu	37	2	107041458	107041458	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:107041458T>C	uc010ywi.1	-	20	3022	c.2965A>G	c.(2965-2967)AAA>GAA	p.K989E		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	989					intracellular transport		binding			ovary(1)	1						TTGAGGTCTTTTTTGCCAAAC	0.393													12	141					0	0	0.001855	0	0
RGPD3	653489	broad.mit.edu	37	2	107041599	107041599	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:107041599C>T	uc010ywi.1	-	20	2881	c.2824G>A	c.(2824-2826)GAA>AAA	p.E942K		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	942					intracellular transport		binding			ovary(1)	1						GTATCATTTTCAAGAGGCTTT	0.418													51	211					0	0	0.014410	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626859	108626859	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:108626859G>A	uc002tdv.2	+	9	1561	c.1285G>A	c.(1285-1287)GGA>AGA	p.G429R	SLC5A7_uc010ywm.1_Missense_Mutation_p.G182R|SLC5A7_uc010fjj.2_Missense_Mutation_p.G429R|SLC5A7_uc010ywn.1_Missense_Mutation_p.G316R	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	429	Extracellular (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CTTTGTTAAGGGAACCAACAC	0.488													7	41					0	0	0.001984	0	0
SULT1C2	6819	broad.mit.edu	37	2	108917375	108917375	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:108917375G>A	uc002tdy.2	+	4	812	c.359G>A	c.(358-360)TGG>TAG	p.W120*	SULT1C2_uc010ywp.1_Nonsense_Mutation_p.W35*|SULT1C2_uc002tdx.2_Nonsense_Mutation_p.W131*|SULT1C2_uc010ywq.1_Nonsense_Mutation_p.W134*	NM_001056	NP_001047	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 1	120					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			ovary(1)	1						CCGTCTTTCTGGGAAAACAAC	0.493													18	86					0	0	0.007413	0	0
PSD4	23550	broad.mit.edu	37	2	113951444	113951444	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:113951444G>A	uc002tjc.2	+	10	2283	c.2100G>A	c.(2098-2100)GGG>GGA	p.G700G	PSD4_uc002tjd.2_Silent_p.G321G|PSD4_uc002tje.2_Silent_p.G671G|PSD4_uc002tjf.2_Silent_p.G321G	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	700	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						AGAACATTGGGAAGAGCATGA	0.547													6	50					0	0	0.004482	0	0
CCDC93	54520	broad.mit.edu	37	2	118766131	118766131	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:118766131G>A	uc002tlj.2	-	2	272	c.146C>T	c.(145-147)CCC>CTC	p.P49L	CCDC93_uc010fld.1_Missense_Mutation_p.P49L	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	49										large_intestine(1)|ovary(1)	2						CTTGTCAAAGGGTGATAAGCC	0.378													9	63					0	0	0.008291	0	0
CNTNAP5	129684	broad.mit.edu	37	2	124783231	124783231	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:124783231G>A	uc002tno.2	+	1	368	c.4G>A	c.(4-6)GAT>AAT	p.D2N	CNTNAP5_uc010flu.2_Missense_Mutation_p.D2N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	2					cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGGGGAAATGGATTCTTTACC	0.552													4	45					0	0	0.001168	0	0
MYO7B	4648	broad.mit.edu	37	2	128335722	128335722	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:128335722C>T	uc002top.2	+	9	917	c.864C>T	c.(862-864)TCC>TCT	p.S288S		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	288	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ACTGCACTTCCTGTGAGGGGC	0.627													3	18					0	0	0.004672	0	0
POTEF	728378	broad.mit.edu	37	2	130869621	130869621	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:130869621C>T	uc010fmh.2	-	6	1264	c.864G>A	c.(862-864)GTG>GTA	p.V288V		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	288	ANK 4.					cell cortex	ATP binding			skin(3)|ovary(2)	5						TTAAAAATTTCACGACTTGCT	0.333													7	26					0	0	0.003080	0	0
FAM123C	205147	broad.mit.edu	37	2	131520094	131520094	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:131520094G>A	uc002trw.2	+	2	639	c.449G>A	c.(448-450)AGG>AAG	p.R150K	FAM123C_uc010fmv.2_Missense_Mutation_p.R150K|FAM123C_uc010fms.1_Missense_Mutation_p.R150K|FAM123C_uc010fmt.1_Missense_Mutation_p.R150K|FAM123C_uc010fmu.1_Missense_Mutation_p.R150K	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	150										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CCGAGGAAGAGGATTTCCCTG	0.602													6	41					0	0	0.001984	0	0
FAM123C	205147	broad.mit.edu	37	2	131520837	131520837	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:131520837G>A	uc002trw.2	+	2	1382	c.1192G>A	c.(1192-1194)GAC>AAC	p.D398N	FAM123C_uc010fmv.2_Missense_Mutation_p.D398N|FAM123C_uc010fms.1_Missense_Mutation_p.D398N|FAM123C_uc010fmt.1_Missense_Mutation_p.D398N|FAM123C_uc010fmu.1_Missense_Mutation_p.D398N	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	398										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		ACTTGAGGAGGACAAGAAGGA	0.617													6	29					0	0	0.001168	0	0
FAM168B	130074	broad.mit.edu	37	2	131812892	131812892	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:131812892C>T	uc002tsd.2	-	5	657	c.428G>A	c.(427-429)GGG>GAG	p.G143E		NM_001009993	NP_001009993	A1KXE4	F168B_HUMAN	hypothetical protein LOC130074	143											0						CATGGTGACCCCGTTGCCTCT	0.632													8	79					0	0	0.006214	0	0
GPR39	2863	broad.mit.edu	37	2	133174903	133174903	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:133174903G>A	uc002ttl.2	+	1	757	c.288G>A	c.(286-288)TGG>TGA	p.W96*		NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	96	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						GCATCATCTGGAATCCCCTGA	0.557													6	59					0	0	0.003080	0	0
THSD7B	80731	broad.mit.edu	37	2	137814260	137814260	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:137814260G>A	uc002tva.1	+	2	317	c.317G>A	c.(316-318)GGA>GAA	p.G106E	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_5'UTR	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCTCAGCATGGACTGCAGCAC	0.537													6	26					0	0	0.001168	0	0
THSD7B	80731	broad.mit.edu	37	2	137814413	137814413	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:137814413G>A	uc002tva.1	+	2	470	c.470G>A	c.(469-471)TGG>TAG	p.W157*	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Nonsense_Mutation_p.W47*	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTCTTACCATGGTCCAACTGT	0.488													19	133					0	0	0.008871	0	0
LRP1B	53353	broad.mit.edu	37	2	141215150	141215150	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:141215150C>T	uc002tvj.1	-	61	10668	c.9696G>A	c.(9694-9696)GGG>GGA	p.G3232G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3232	Extracellular (Potential).|LDL-receptor class B 32.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACTTGGTTTTCCCATCAGTCC	0.428										TSP Lung(27;0.18)			12	36					0	0	0.002450	0	0
EPC2	26122	broad.mit.edu	37	2	149542258	149542258	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:149542258C>T	uc010zbt.1	+	13	2066	c.2039C>T	c.(2038-2040)TCC>TTC	p.S680F		NM_015630	NP_056445	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2	680					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)		ACATTATACTCCACCAATATG	0.373													8	48					0	0	0.006214	0	0
NEB	4703	broad.mit.edu	37	2	152484210	152484210	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:152484210T>A	uc010fnx.2	-	65	9432	c.9241A>T	c.(9241-9243)AAG>TAG	p.K3081*		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3081	Nebulin 83.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTCTTCCACTTCTCAAAGTCC	0.507													37	238					0	0	0.008740	0	0
LY75	4065	broad.mit.edu	37	2	160721408	160721408	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:160721408C>T	uc002ubc.3	-	14	2210	c.2141G>A	c.(2140-2142)GGT>GAT	p.G714D	LY75_uc002ubb.3_Missense_Mutation_p.G714D|LY75_uc010fos.2_Missense_Mutation_p.G714D	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	714	Extracellular (Potential).|C-type lectin 4.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TTTATTCAAACCAATCCACAG	0.383													4	47					0	0	0.000602	0	0
IFIH1	64135	broad.mit.edu	37	2	163124040	163124040	+	Silent	SNP	C	T	T	rs77041372		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:163124040C>T	uc002uce.2	-	15	3069	c.2847G>A	c.(2845-2847)AAG>AAA	p.K949K		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	949					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						CGGCACACTTCTTTTGCAGTG	0.383													5	41					0	0	0.001168	0	0
KCNH7	90134	broad.mit.edu	37	2	163241236	163241236	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:163241236C>T	uc002uch.1	-	13	3136	c.2924G>A	c.(2923-2925)GGA>GAA	p.G975E		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	975	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	GTGCATTCTTCCTGAGGTGGG	0.428													9	60					0	0	0.004482	0	0
SCN9A	6335	broad.mit.edu	37	2	167056193	167056193	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:167056193G>A	uc010fpl.2	-	27	5264	c.4923C>T	c.(4921-4923)TTC>TTT	p.F1641F	uc002udp.2_RNA	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1652	Helical; Name=S5 of repeat IV; (Potential).|IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	ACATGACCAGGAAGAGCAGGA	0.448													7	57					0	0	0.004482	0	0
XIRP2	129446	broad.mit.edu	37	2	168107274	168107274	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:168107274C>T	uc002udx.2	+	8	9390	c.9372C>T	c.(9370-9372)ATC>ATT	p.I3124I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.I2949I|XIRP2_uc010fpq.2_Silent_p.I2902I|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2949					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAACTTTTATCACAATAGAAT	0.443													7	42					0	0	0.004482	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169684963	169684963	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:169684963A>G	uc002ueg.2	+	5	298	c.294A>G	c.(292-294)ATA>ATG	p.I98M	NOSTRIN_uc002uef.2_Missense_Mutation_p.I98M|NOSTRIN_uc002uei.2_Translation_Start_Site|NOSTRIN_uc010fpu.2_Missense_Mutation_p.I70M|NOSTRIN_uc002ueh.2_Missense_Mutation_p.I20M|NOSTRIN_uc002uej.2_Translation_Start_Site	NM_001039724	NP_001034813	Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficker isoform 2	98					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0						TGGAAGCAATAAAACCGACTT	0.328													9	67					0	0	0.008291	0	0
ABCB11	8647	broad.mit.edu	37	2	169874613	169874613	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:169874613C>T	uc002ueo.1	-	2	149	c.23G>A	c.(22-24)CGA>CAA	p.R8Q		NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	8	Cytoplasmic (Potential).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTTTATACTTCGAAGAATTAC	0.363													6	47					0	0	0.001168	0	0
LRP2	4036	broad.mit.edu	37	2	170044544	170044544	+	Silent	SNP	G	A	A	rs143637076		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:170044544G>A	uc002ues.2	-	49	9477	c.9264C>T	c.(9262-9264)ATC>ATT	p.I3088I		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3088	Extracellular (Potential).|LDL-receptor class A 25.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCATCATCTCGATGCAGCGCC	0.512													11	56					0	0	0.013537	0	0
LRP2	4036	broad.mit.edu	37	2	170058237	170058237	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:170058237C>T	uc002ues.2	-	44	8566	c.8353G>A	c.(8353-8355)GAG>AAG	p.E2785K		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2785	LDL-receptor class A 18.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CACATAAACTCCGTGGTGGCA	0.463													4	46					0	0	0.009096	0	0
LRP2	4036	broad.mit.edu	37	2	170115567	170115567	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:170115567G>A	uc002ues.2	-	17	2694	c.2481C>T	c.(2479-2481)AAC>AAT	p.N827N	LRP2_uc010zdf.1_Silent_p.N690N	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	827	LDL-receptor class B 7.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCGACCGTGGGTTATTTAAAT	0.398													12	45					0	0	0.010729	0	0
LRP2	4036	broad.mit.edu	37	2	170136033	170136033	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:170136033G>A	uc002ues.2	-	12	1627	c.1414C>T	c.(1414-1416)CTG>TTG	p.L472L	LRP2_uc010zdf.1_Silent_p.L472L	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	472	LDL-receptor class B 1.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCCACAGCCAGGTTCTCTGGG	0.353													11	60					0	0	0.001855	0	0
UBR3	130507	broad.mit.edu	37	2	170806490	170806490	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:170806490G>A	uc010zdi.1	+	23	3460	c.3460G>A	c.(3460-3462)GAA>AAA	p.E1154K	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_5'UTR|UBR3_uc002uft.3_Missense_Mutation_p.E7K	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1154					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0						ACGCATCATTGAAGAGATATG	0.363													7	65					0	0	0.003080	0	0
PDK1	5163	broad.mit.edu	37	2	173451030	173451030	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:173451030C>T	uc002uhr.2	+	9	1070	c.970C>T	c.(970-972)CCT>TCT	p.P324S	PDK1_uc010zdz.1_Missense_Mutation_p.P169S|PDK1_uc010zea.1_RNA|PDK1_uc002uhq.1_Missense_Mutation_p.P344S|PDK1_uc002uhs.2_Missense_Mutation_p.P324S|PDK1_uc010zeb.1_Missense_Mutation_p.P344S	NM_002610	NP_002601	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase 1 precursor	324	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity	p.P324S(1)		lung(3)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.12)			AGGTGGCGTTCCTTTGAGGAA	0.443									Autosomal_Dominant_Polycystic_Kidney_Disease				7	28					0	0	0.003080	0	0
ATP5G3	518	broad.mit.edu	37	2	176043862	176043862	+	Silent	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:176043862A>C	uc002ujz.3	-	3	507	c.237T>G	c.(235-237)GGT>GGG	p.G79G	ATP5G3_uc002uka.3_Silent_p.G79G|ATP5G3_uc002ukb.1_Silent_p.G79G	NM_001002258	NP_001002258	P48201	AT5G3_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	79					ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.147)			CTGTTGCAGCACCTGCACCAA	0.463													5	43					0	0	0.000602	0	0
MIR1246	100302142	broad.mit.edu	37	2	177465721	177465721	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:177465721G>A	hsa-mir-1246|MI0006381	-			c.60G>A																				0						gctagcctatggattgatttc	0.159													11	116					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179408644	179408644	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179408644T>A	uc010zfg.1	-	295	88747	c.88523A>T	c.(88522-88524)AAT>ATT	p.N29508I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N23203I|TTN_uc010zfi.1_Missense_Mutation_p.N23136I|TTN_uc010zfj.1_Missense_Mutation_p.N23011I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30435							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCGTACCGATTAACTTTGTC	0.423													18	64					0	0	0.004990	0	0
TTN	7273	broad.mit.edu	37	2	179431214	179431214	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179431214C>T	uc010zfg.1	-	275	72165	c.71941G>A	c.(71941-71943)GAA>AAA	p.E23981K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E17676K|TTN_uc010zfi.1_Missense_Mutation_p.E17609K|TTN_uc010zfj.1_Missense_Mutation_p.E17484K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24908							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGAAATTTCAAATCGAGTG	0.418													28	93					0	0	0.007291	0	0
TTN	7273	broad.mit.edu	37	2	179474925	179474925	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179474925C>T	uc010zfg.1	-	220	43848	c.43624G>A	c.(43624-43626)GAT>AAT	p.D14542N	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D8237N|TTN_uc010zfi.1_Missense_Mutation_p.D8170N|TTN_uc010zfj.1_Missense_Mutation_p.D8045N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15469							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTATGAGATCCTTCACAGTC	0.423													12	140					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179480053	179480053	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179480053C>T	uc010zfg.1	-	208	41139	c.40915G>A	c.(40915-40917)GAA>AAA	p.E13639K	uc002ump.1_RNA|TTN_uc010zfh.1_Missense_Mutation_p.E7334K|TTN_uc010zfi.1_Missense_Mutation_p.E7267K|TTN_uc010zfj.1_Missense_Mutation_p.E7142K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14566							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAACAGGTTCTCCACAGGCA	0.383													5	71					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179528012	179528012	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179528012C>T	uc010zfk.1	-	18	1667	c.1119G>A	c.(1117-1119)CCG>CCA	p.P373P	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	11585							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGGACTTTCCGGTTTGGGAG	0.373													4	28					0	0	0.001168	0	0
TTN	7273	broad.mit.edu	37	2	179544115	179544115	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179544115C>T	uc010zfg.1	-	139	30185	c.29961G>A	c.(29959-29961)GAG>GAA	p.E9987E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.E6648E|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10914							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGGAACTTTCTCCTCTGGCT	0.383													9	58					0	0	0.013537	0	0
TTN	7273	broad.mit.edu	37	2	179569978	179569978	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179569978C>T	uc010zfg.1	-	100	26019	c.25795G>A	c.(25795-25797)GGA>AGA	p.G8599R	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G5260R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9526							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGTGATTCCATACATGCGG	0.378													14	53					0	0	0.002450	0	0
TTN	7273	broad.mit.edu	37	2	179584942	179584942	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179584942C>T	uc010zfg.1	-	78	19919	c.19695G>A	c.(19693-19695)GGG>GGA	p.G6565G	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.G3226G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7492							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAACAGCATCCCCAATAAGGG	0.443													4	41					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179585867	179585867	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179585867G>A	uc010zfg.1	-	76	19371	c.19147C>T	c.(19147-19149)CAA>TAA	p.Q6383*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.Q3044*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7310							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTCCAGTTGAATGGATTCT	0.358													13	29					0	0	0.013537	0	0
TTN	7273	broad.mit.edu	37	2	179594268	179594268	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179594268C>T	uc010zfg.1	-	61	15107	c.14883G>A	c.(14881-14883)CTG>CTA	p.L4961L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.L1622L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5888							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACAGGCTTCAGCTCTCTGA	0.463													10	61					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179594516	179594516	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179594516G>A	uc010zfg.1	-	60	14956	c.14732C>T	c.(14731-14733)TCC>TTC	p.S4911F	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S1572F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5838							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCAATGAAGGAAATGCCATG	0.443													9	58					0	0	0.006214	0	0
TTN	7273	broad.mit.edu	37	2	179604990	179604990	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179604990C>T	uc010zfh.1	-	46	12681	c.12457G>A	c.(12457-12459)GAA>AAA	p.E4153K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E4086K|TTN_uc010zfj.1_Missense_Mutation_p.E3961K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTTGCCTTCCTCAATTCTG	0.443													7	70					0	0	0.003080	0	0
TTN	7273	broad.mit.edu	37	2	179605694	179605694	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179605694T>G	uc010zfh.1	-	46	11977	c.11753A>C	c.(11752-11754)AAC>ACC	p.N3918T	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.N3851T|TTN_uc010zfj.1_Missense_Mutation_p.N3726T|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGTTGCTGGTTTTCTTCTGT	0.418													9	68					0	0	0.006214	0	0
TTN	7273	broad.mit.edu	37	2	179606133	179606133	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179606133C>T	uc010zfh.1	-	46	11538	c.11314G>A	c.(11314-11316)GAG>AAG	p.E3772K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E3705K|TTN_uc010zfj.1_Missense_Mutation_p.E3580K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	3730							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTTTTAACTCCTTAAGGAAG	0.463													17	119					0	0	0.006122	0	0
TTN	7273	broad.mit.edu	37	2	179610943	179610943	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179610943G>A	uc002unb.2	-	46	16408	c.16184C>T	c.(16183-16185)TCA>TTA	p.S5395L	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACAGCATCTGAATTTTCTGG	0.338													12	30					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179640441	179640441	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179640441C>T	uc010zfg.1	-	28	6374	c.6150G>A	c.(6148-6150)AAG>AAA	p.K2050K	TTN_uc010zfh.1_Silent_p.K2004K|TTN_uc010zfi.1_Silent_p.K2004K|TTN_uc010zfj.1_Silent_p.K2004K|TTN_uc002unb.2_Silent_p.K2050K|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2050							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGAGCTTTCTTTTCCTCTT	0.408													14	70					0	0	0.004990	0	0
TTN	7273	broad.mit.edu	37	2	179640842	179640842	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179640842G>A	uc010zfg.1	-	28	5973	c.5749C>T	c.(5749-5751)CCT>TCT	p.P1917S	TTN_uc010zfh.1_Missense_Mutation_p.P1871S|TTN_uc010zfi.1_Missense_Mutation_p.P1871S|TTN_uc010zfj.1_Missense_Mutation_p.P1871S|TTN_uc002unb.2_Missense_Mutation_p.P1917S|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1917							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACCTTCAGGATTTTCCGCG	0.453													25	136					0	0	0.003954	0	0
TTN	7273	broad.mit.edu	37	2	179658217	179658217	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179658217C>T	uc010zfg.1	-	9	1674	c.1450G>A	c.(1450-1452)GAT>AAT	p.D484N	TTN_uc010zfh.1_Missense_Mutation_p.D484N|TTN_uc010zfi.1_Missense_Mutation_p.D484N|TTN_uc010zfj.1_Missense_Mutation_p.D484N|TTN_uc002unb.2_Missense_Mutation_p.D484N|TTN_uc010frg.1_Missense_Mutation_p.D158N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	484							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGCTTTATCGGCGGCCACT	0.398													18	40					0	0	0.007413	0	0
CCDC141	285025	broad.mit.edu	37	2	179702427	179702427	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:179702427C>T	uc002unf.1	-	13	1851	c.1794G>A	c.(1792-1794)GGG>GGA	p.G598G	CCDC141_uc002une.1_Silent_p.G48G	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	598							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GTCGCTCTTCCCCTGTTCCAT	0.483													4	81					0	0	0.000602	0	0
ZNF385B	151126	broad.mit.edu	37	2	180309666	180309666	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:180309666C>T	uc002unn.3	-	9	1738	c.1134G>A	c.(1132-1134)GGG>GGA	p.G378G	ZNF385B_uc002unj.2_Silent_p.G276G|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Silent_p.G275G|ZNF385B_uc002unm.2_Silent_p.G302G	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	378	Matrin-type 4.					nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TCAGTGGTTTCCCTGCAACTC	0.443													27	104					0	0	0.009535	0	0
ITGA4	3676	broad.mit.edu	37	2	182339977	182339977	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:182339977G>A	uc002unu.2	+	4	1281	c.518G>A	c.(517-519)CGA>CAA	p.R173Q	ITGA4_uc010zfl.1_Missense_Mutation_p.R173Q	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	173	FG-GAP 2.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CCTGATTTACGAACAGAACTG	0.348													8	63					0	0	0.008291	0	0
ITGA4	3676	broad.mit.edu	37	2	182399546	182399546	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:182399546C>T	uc002unu.2	+	27	3650	c.2887C>T	c.(2887-2889)CTA>TTA	p.L963L	ITGA4_uc002unv.2_Silent_p.L208L	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	963	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CACGTAGGTTCTACTGGAAGG	0.338													6	29					0	0	0.001984	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543404	182543404	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:182543404C>T	uc002uof.2	-	2	420	c.184G>A	c.(184-186)GAA>AAA	p.E62K	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	62	Glu-rich (acidic).				amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			tcctcatcttcgtcctcctcc	0.398													76	230					0	0	0.014410	0	0
DNAJC10	54431	broad.mit.edu	37	2	183601062	183601062	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:183601062T>C	uc002uow.1	+	11	1351	c.936T>C	c.(934-936)GCT>GCC	p.A312A	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Intron|DNAJC10_uc010fro.1_Intron	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	312					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GTACTACTGCTTATTTTCCTC	0.338													6	26					0	0	0.001168	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800528	185800528	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:185800528C>T	uc002uph.2	+	4	999	c.405C>T	c.(403-405)CCC>CCT	p.P135P		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	135						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAAGTGGCCCCATGTTCAAAT	0.333													4	30					0	0	0.000602	0	0
CALCRL	10203	broad.mit.edu	37	2	188216844	188216844	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:188216844G>A	uc002upv.3	-	13	1673	c.1125C>T	c.(1123-1125)TTC>TTT	p.F375F	CALCRL_uc010frt.2_Silent_p.F375F	NM_005795	NP_005786	Q16602	CALRL_HUMAN	calcitonin receptor-like precursor	375	Helical; Name=7; (Potential).					integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			GCCATACCTGGAAGTGCATAA	0.398													6	45					0	0	0.001168	0	0
TFPI	7035	broad.mit.edu	37	2	188332622	188332622	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:188332622G>C	uc002upx.2	-	7	699	c.666C>G	c.(664-666)GAC>GAG	p.D222E	TFPI_uc002upy.2_Missense_Mutation_p.D222E|TFPI_uc002upz.2_Missense_Mutation_p.D218E	NM_006287	NP_006278	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor isoform a	222	BPTI/Kunitz inhibitor 3.				blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	ACAATCCTCTGTCTGCTGGAG	0.423													5	32					0	0	0.001168	0	0
COL3A1	1281	broad.mit.edu	37	2	189859818	189859818	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:189859818G>A	uc002uqj.1	+	21	1619	c.1502G>A	c.(1501-1503)GGA>GAA	p.G501E		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	501	Triple-helical region.		G -> R (in EDS4).		axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGCATCCCAGGAGAAAAGGTA	0.388													5	50					0	0	0.000602	0	0
STAT4	6775	broad.mit.edu	37	2	192012813	192012813	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:192012813T>A	uc002usm.1	-	2	371	c.117A>T	c.(115-117)GAA>GAT	p.E39D	STAT4_uc010zgm.1_RNA|STAT4_uc010zgn.1_RNA|STAT4_uc010zgo.1_RNA|STAT4_uc002usn.1_Missense_Mutation_p.E39D|STAT4_uc002uso.2_Missense_Mutation_p.E39D|STAT4_uc002usp.3_Missense_Mutation_p.E39D|STAT4_uc010zgl.1_Missense_Mutation_p.E39D	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	39					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			AGTCTTGATTTTCAATCCATT	0.373													8	39					0	0	0.004482	0	0
MYO1B	4430	broad.mit.edu	37	2	192252042	192252042	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:192252042C>T	uc010fsg.2	+	17	1902	c.1647C>T	c.(1645-1647)CTC>CTT	p.L549L	MYO1B_uc002usq.2_Silent_p.L549L|MYO1B_uc002usr.2_Silent_p.L549L|MYO1B_uc002ust.1_Silent_p.L187L	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	549	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GCCATGCCCTCATCAAGTCTT	0.522													6	65					0	0	0.001168	0	0
MYO1B	4430	broad.mit.edu	37	2	192272864	192272864	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:192272864C>T	uc010fsg.2	+	25	2835	c.2580C>T	c.(2578-2580)TTC>TTT	p.F860F	MYO1B_uc002usq.2_Silent_p.F802F|MYO1B_uc002usr.2_Silent_p.F860F|MYO1B_uc002usu.2_Silent_p.F105F|MYO1B_uc002usv.2_5'UTR	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	860	IQ 6.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			ACAGGAAATTCTTCAGAGCCA	0.363													4	30					0	0	0.000602	0	0
DNAH7	56171	broad.mit.edu	37	2	196605556	196605556	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:196605556G>A	uc002utj.3	-	64	11903	c.11802C>T	c.(11800-11802)TCC>TCT	p.S3934S	DNAH7_uc002uti.3_Silent_p.S417S	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3934					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTCTATTCCAGGAAGCTCCAT	0.308													5	98					0	0	0.001984	0	0
DNAH7	56171	broad.mit.edu	37	2	196620936	196620936	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:196620936C>T	uc002utj.3	-	62	11608	c.11507G>A	c.(11506-11508)TGG>TAG	p.W3836*	DNAH7_uc002uti.3_Nonsense_Mutation_p.W319*	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3836					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTTACCCATCCACATTTCTGG	0.398													5	37					0	0	0.000602	0	0
DNAH7	56171	broad.mit.edu	37	2	196729123	196729123	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:196729123C>T	uc002utj.3	-	41	7357	c.7256G>A	c.(7255-7257)GGG>GAG	p.G2419E		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2419	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGGAATCTCCCCAGCATTTAG	0.418													5	31					0	0	0.000602	0	0
DNAH7	56171	broad.mit.edu	37	2	196753607	196753607	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:196753607C>T	uc002utj.3	-	32	5246	c.5145G>A	c.(5143-5145)CTG>CTA	p.L1715L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1715	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CCCCACTCATCAGACATAGCT	0.403													12	59					0	0	0.010729	0	0
DNAH7	56171	broad.mit.edu	37	2	196791250	196791250	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:196791250C>T	uc002utj.3	-	22	3613	c.3512G>A	c.(3511-3513)CGA>CAA	p.R1171Q		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1171	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CCAGTTAATTCGTTCATATTT	0.353													8	43					0	0	0.010729	0	0
SF3B1	23451	broad.mit.edu	37	2	198285164	198285164	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:198285164G>A	uc002uue.2	-	4	451	c.403C>T	c.(403-405)CCT>TCT	p.P135S	SF3B1_uc010fsk.1_RNA|SF3B1_uc002uuf.2_Missense_Mutation_p.P135S|SF3B1_uc002uug.2_Missense_Mutation_p.P135S	NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	135					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCTGCAAAAGGATCAAGACGC	0.383													5	57					0	0	0.001168	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202400826	202400826	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:202400826A>G	uc002uye.2	-	13	1472	c.1424T>C	c.(1423-1425)ATG>ACG	p.M475T	ALS2CR11_uc002uyf.2_Missense_Mutation_p.M475T|ALS2CR11_uc010fti.2_Intron	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	475										large_intestine(1)|ovary(1)|skin(1)	3						TACATTTTTCATTTTTCTGTC	0.343													10	70					0	0	0.006214	0	0
ALS2	57679	broad.mit.edu	37	2	202598155	202598155	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:202598155G>A	uc002uyo.2	-	13	2780	c.2424C>T	c.(2422-2424)TTC>TTT	p.F808F	ALS2_uc002uyp.3_Silent_p.F808F|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	808	DH.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TTTTATTTAGGAAATCACTAG	0.303													4	29					0	0	0.000602	0	0
NBEAL1	65065	broad.mit.edu	37	2	203980710	203980710	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:203980710C>T	uc002uzt.3	+	17	2755	c.2422C>T	c.(2422-2424)CCA>TCA	p.P808S		NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	808							binding			ovary(1)|skin(1)	2						ATTTTCAGGTCCAAATTGTTT	0.373													21	270					0	0	0.002780	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170420	207170420	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:207170420G>A	uc002vbp.2	+	5	1418	c.1168G>A	c.(1168-1170)GAG>AAG	p.E390K		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	390							nucleic acid binding|zinc ion binding			ovary(3)	3						TCTTTGGAAGGAGGAGCAAAT	0.403													7	22					0	0	0.001984	0	0
MDH1B	130752	broad.mit.edu	37	2	207613758	207613758	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:207613758C>T	uc002vbs.2	-	7	1257	c.1202G>A	c.(1201-1203)GGA>GAA	p.G401E	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.G401E|MDH1B_uc010fuj.2_Missense_Mutation_p.G303E|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	401					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		ACTCAATATTCCTAAAGATAC	0.413													8	34					0	0	0.006214	0	0
MDH1B	130752	broad.mit.edu	37	2	207615786	207615786	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:207615786C>T	uc002vbs.2	-	6	979	c.924G>A	c.(922-924)GTG>GTA	p.V308V	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Silent_p.V308V|MDH1B_uc010fuj.2_Silent_p.V210V|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	308					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		CCCAAATGATCACGTCTTTAA	0.313													13	49					0	0	0.001855	0	0
PTH2R	5746	broad.mit.edu	37	2	209308228	209308228	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:209308228C>T	uc002vdb.2	+	6	878	c.665C>T	c.(664-666)TCC>TTC	p.S222F	PTH2R_uc010zjb.1_Missense_Mutation_p.S233F	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	222	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		CCACAAAATTCCATTGAGGCA	0.373													7	31					0	0	0.006214	0	0
MAP2	4133	broad.mit.edu	37	2	210557907	210557907	+	Missense_Mutation	SNP	C	T	T	rs144486691		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:210557907C>T	uc002vde.1	+	7	1261	c.1013C>T	c.(1012-1014)TCG>TTG	p.S338L	MAP2_uc002vdc.1_Missense_Mutation_p.S338L|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.S334L	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	338					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	ACAGAAACATCGCCCTTTGCC	0.438													5	36					0	0	0.001168	0	0
ACADL	33	broad.mit.edu	37	2	211082805	211082805	+	Silent	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:211082805T>A	uc002vdz.3	-	3	483	c.255A>T	c.(253-255)GTA>GTT	p.V85V	ACADL_uc010zjg.1_Silent_p.V85V	NM_001608	NP_001599	P28330	ACADL_HUMAN	long-chain acyl-CoA dehydrogenase precursor	85					carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity				0		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		CCTCCCTACTTACTTCTCCAG	0.358													6	25					0	0	0.001168	0	0
ERBB4	2066	broad.mit.edu	37	2	212488669	212488669	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:212488669C>T	uc002veg.1	-	18	2278	c.2180G>A	c.(2179-2181)GGT>GAT	p.G727D	ERBB4_uc002veh.1_Missense_Mutation_p.G727D|ERBB4_uc010zji.1_Missense_Mutation_p.G717D|ERBB4_uc010zjj.1_Missense_Mutation_p.G717D|ERBB4_uc010fut.1_Missense_Mutation_p.G727D	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	727	ATP (By similarity).|Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCCAAAAGCACCTGAGCCAAG	0.373										TSP Lung(8;0.080)			5	41					0	0	0.001168	0	0
ABCA12	26154	broad.mit.edu	37	2	215843724	215843724	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:215843724G>A	uc002vew.2	-	32	5001	c.4781C>T	c.(4780-4782)GCC>GTC	p.A1594V	ABCA12_uc002vev.2_Missense_Mutation_p.A1276V|ABCA12_uc010zjn.1_Missense_Mutation_p.A521V	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1594					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGCTGTCACGGCCATGGTGTC	0.443													10	20					0	0	0.013537	0	0
ABCA12	26154	broad.mit.edu	37	2	215851397	215851397	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:215851397G>A	uc002vew.2	-	28	4252	c.4032C>T	c.(4030-4032)GTC>GTT	p.V1344V	ABCA12_uc002vev.2_Silent_p.V1026V|ABCA12_uc010zjn.1_Silent_p.V271V	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1344					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GGGCAACCCCGACTGTGAGAT	0.428													13	42					0	0	0.001855	0	0
CXCR2	3579	broad.mit.edu	37	2	219000408	219000408	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:219000408C>T	uc002vgz.1	+	4	1109	c.884C>T	c.(883-885)GCT>GTT	p.A295V	CXCR2_uc002vha.1_Missense_Mutation_p.A295V|CXCR2_uc002vhb.1_Missense_Mutation_p.A295V	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	295	Helical; Name=7; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						ATCGACCGGGCTCTGGATGCC	0.587													9	67					0	0	0.006214	0	0
AAMP	14	broad.mit.edu	37	2	219134173	219134173	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:219134173G>A	uc002vhk.2	-	2	290	c.206C>T	c.(205-207)CCC>CTC	p.P69L	PNKD_uc002vhn.2_5'Flank|AAMP_uc002vhj.2_Missense_Mutation_p.P50L|AAMP_uc010fvo.2_Missense_Mutation_p.P69L|AAMP_uc002vhl.2_Missense_Mutation_p.P70L|PNKD_uc002vhm.1_5'Flank	NM_001087	NP_001078	Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	69					angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCTTCCTGGGGTTCTAGAAC	0.572													6	47					0	0	0.001168	0	0
VIL1	7429	broad.mit.edu	37	2	219292991	219292991	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:219292991C>T	uc002via.2	+	6	563	c.498C>T	c.(496-498)TTC>TTT	p.F166F	VIL1_uc010zke.1_Intron|VIL1_uc002vib.2_Silent_p.F166F|VIL1_uc002vic.1_Silent_p.F166F	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	166	Gelsolin-like 2.|Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGATGTTTTCCTCCTGGACC	0.547													7	48					0	0	0.001984	0	0
CCDC108	255101	broad.mit.edu	37	2	219870235	219870235	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:219870235C>T	uc002vjl.1	-	32	5056	c.4972G>A	c.(4972-4974)GAA>AAA	p.E1658K		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	1658						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGATTTTTCCTCAGAAGTC	0.562													4	47					0	0	0.000602	0	0
CCDC108	255101	broad.mit.edu	37	2	219895422	219895422	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:219895422T>G	uc002vjl.1	-	9	1234	c.1150A>C	c.(1150-1152)AAC>CAC	p.N384H	CCDC108_uc010fwa.1_5'Flank|CCDC108_uc010zkp.1_Missense_Mutation_p.N373H|CCDC108_uc010zkq.1_Missense_Mutation_p.N319H	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	384						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCGACGGGTTGTGTAGCCTG	0.612													3	55					0	0	0.004672	0	0
CCDC108	255101	broad.mit.edu	37	2	219895424	219895424	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:219895424T>G	uc002vjl.1	-	9	1232	c.1148A>C	c.(1147-1149)CAC>CCC	p.H383P	CCDC108_uc010fwa.1_5'Flank|CCDC108_uc010zkp.1_Missense_Mutation_p.H372P|CCDC108_uc010zkq.1_Missense_Mutation_p.H318P	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	383						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGACGGGTTGTGTAGCCTGAT	0.612													3	55					0	0	0.004672	0	0
FAM134A	79137	broad.mit.edu	37	2	220043652	220043652	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:220043652C>T	uc002vjw.3	+	2	426	c.290C>T	c.(289-291)TCT>TTT	p.S97F	C2orf24_uc002vju.3_5'Flank|C2orf24_uc002vjv.2_5'Flank|FAM134A_uc010fwc.2_5'UTR|FAM134A_uc002vjx.2_5'Flank	NM_024293	NP_077269	Q8NC44	F134A_HUMAN	hypothetical protein LOC79137	97	Poly-Ser.					endoplasmic reticulum|integral to membrane				ovary(1)|central_nervous_system(1)	2		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGTTGCTGTCTTCCTCGTCC	0.552													12	121					0	0	0.001855	0	0
DNPEP	23549	broad.mit.edu	37	2	220246064	220246064	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:220246064G>A	uc010zlg.1	-	13	1338	c.1256C>T	c.(1255-1257)CCC>CTC	p.P419L	DNPEP_uc010zlf.1_RNA|DNPEP_uc002vle.2_Missense_Mutation_p.P411L|DNPEP_uc002vlf.1_Missense_Mutation_p.P397L|DNPEP_uc002vlh.2_Missense_Mutation_p.P358L|DNPEP_uc002vli.1_Missense_Mutation_p.P358L	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	401					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	CACCTGCAGGGGGACCTTGAC	0.612													22	167					0	0	0.010818	0	0
DNPEP	23549	broad.mit.edu	37	2	220250763	220250763	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:220250763G>A	uc010zlg.1	-	6	623	c.541C>T	c.(541-543)CGC>TGC	p.R181C	DNPEP_uc010zlf.1_5'Flank|DNPEP_uc002vle.2_Missense_Mutation_p.R173C|DNPEP_uc002vlf.1_Missense_Mutation_p.R159C|DNPEP_uc002vlh.2_Missense_Mutation_p.R120C|DNPEP_uc002vli.1_Missense_Mutation_p.R120C|DNPEP_uc002vlj.2_Missense_Mutation_p.R163C|uc002vlk.1_5'Flank	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	163					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	TGTGGGATGCGAAGAATGGGC	0.632													12	58					0	0	0.003163	0	0
OBSL1	23363	broad.mit.edu	37	2	220428326	220428326	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:220428326G>A	uc010fwk.2	-	7	2488	c.2431C>T	c.(2431-2433)CCC>TCC	p.P811S	OBSL1_uc010zli.1_5'Flank|OBSL1_uc010fwl.1_Missense_Mutation_p.P286S|OBSL1_uc002vmi.2_Missense_Mutation_p.P811S|OBSL1_uc002vmj.2_Missense_Mutation_p.P398S	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	811	Ig-like 6.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		TGTTCTCGGGGGTCCACGATG	0.587													6	52					0	0	0.003080	0	0
OBSL1	23363	broad.mit.edu	37	2	220430018	220430018	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:220430018C>T	uc010fwk.2	-	6	2410	c.2353G>A	c.(2353-2355)GAG>AAG	p.E785K	OBSL1_uc010zli.1_5'Flank|OBSL1_uc010fwl.1_Missense_Mutation_p.E260K|OBSL1_uc002vmi.2_Missense_Mutation_p.E785K|OBSL1_uc002vmj.2_Missense_Mutation_p.E372K	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	785	Ig-like 5.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CACTCAAACTCGCCACTGTCC	0.597											OREG0003987	type=REGULATORY REGION|Gene=BC061909|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	5	17					0	0	0.000602	0	0
INHA	3623	broad.mit.edu	37	2	220439824	220439824	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:220439824G>A	uc002vmk.1	+	2	821	c.677G>A	c.(676-678)GGA>GAA	p.G226E		NM_002191	NP_002182	P05111	INHA_HUMAN	inhibin alpha subunit precursor	226					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CCACCCAGTGGAGGGGAGAGA	0.682													11	24					0	0	0.008291	0	0
EPHA4	2043	broad.mit.edu	37	2	222365857	222365857	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:222365857C>T	uc002vmq.2	-	4	901	c.859G>A	c.(859-861)GAT>AAT	p.D287N	EPHA4_uc002vmr.2_Missense_Mutation_p.D287N|EPHA4_uc010zlm.1_Missense_Mutation_p.D228N|EPHA4_uc010zln.1_Missense_Mutation_p.D287N	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	287	Cys-rich.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CAGGTGGCATCCGTGGAGAGA	0.488													6	22					0	0	0.001984	0	0
DOCK10	55619	broad.mit.edu	37	2	225657756	225657756	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:225657756G>A	uc010fwz.1	-	47	5485	c.5246C>T	c.(5245-5247)TCC>TTC	p.S1749F	DOCK10_uc002vob.2_Missense_Mutation_p.S1743F|DOCK10_uc002voa.2_Missense_Mutation_p.S405F|DOCK10_uc002voc.2_Intron	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1749	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CGAGAGCAGGGATGCTGTGCA	0.438													31	145					0	0	0.004289	0	0
KIAA1486	57624	broad.mit.edu	37	2	226446813	226446813	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:226446813C>T	uc002voe.2	+	4	855	c.680C>T	c.(679-681)TCC>TTC	p.S227F	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_5'UTR	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	227										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		CGGGACTCCTCCTTGTCCCAG	0.582													14	118					0	0	0.004007	0	0
COL4A4	1286	broad.mit.edu	37	2	227945198	227945198	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:227945198C>T	uc010zlt.1	-	24	2418	c.1764G>A	c.(1762-1764)CGG>CGA	p.R588R		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	588	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CATGTCCATCCCGACCATGTG	0.458													6	83					0	0	0.001984	0	0
COL4A3	1285	broad.mit.edu	37	2	228159250	228159250	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:228159250G>A	uc002vom.1	+	39	3544	c.3382G>A	c.(3382-3384)GGC>AGC	p.G1128S	COL4A3_uc002von.1_Missense_Mutation_p.G1128S|COL4A3_uc002voo.1_Missense_Mutation_p.G1128S|COL4A3_uc002vop.1_Missense_Mutation_p.G1128S|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1128	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AGGAATCAAAGGCCTCCTGGG	0.433													24	95					0	0	0.004656	0	0
C2orf83	56918	broad.mit.edu	37	2	228476287	228476287	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:228476287G>A	uc002vph.2	-	3	511	c.276C>T	c.(274-276)CAC>CAT	p.H92H	C2orf83_uc010zlu.1_3'UTR	NM_020161	NP_064546	Q53S99	CB083_HUMAN	hypothetical protein LOC56918 isoform 1	92						membrane	folic acid binding|reduced folate carrier activity				0						GGCCCGCAGGGTGAATGAAGG	0.517													7	54					0	0	0.001984	0	0
SLC19A3	80704	broad.mit.edu	37	2	228564158	228564158	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:228564158G>A	uc002vpi.2	-	3	362	c.273C>T	c.(271-273)ATC>ATT	p.I91I	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Silent_p.I87I	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	91	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	GCCAGGTAATGATGAAACTGA	0.517													21	98					0	0	0.012319	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884047	228884047	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:228884047C>T	uc002vpq.2	-	7	1570	c.1523G>A	c.(1522-1524)GGA>GAA	p.G508E	SPHKAP_uc002vpp.2_Missense_Mutation_p.G508E|SPHKAP_uc010zlx.1_Missense_Mutation_p.G508E	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	508						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGAAATAGTTCCAATCACAGT	0.522													5	18					0	0	0.000602	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884669	228884669	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:228884669G>A	uc002vpq.2	-	7	948	c.901C>T	c.(901-903)CCC>TCC	p.P301S	SPHKAP_uc002vpp.2_Missense_Mutation_p.P301S|SPHKAP_uc010zlx.1_Missense_Mutation_p.P301S	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	301						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTGGCTGAGGGATCTAGACTC	0.403													38	110					0	0	0.004878	0	0
SPHKAP	80309	broad.mit.edu	37	2	229046312	229046312	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:229046312C>T	uc002vpq.2	-	1	50	c.3G>A	c.(1-3)ATG>ATA	p.M1I	SPHKAP_uc002vpp.2_Missense_Mutation_p.M1I|SPHKAP_uc010zlx.1_Missense_Mutation_p.M1I	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AGTTGCCATCCATTGTTGGTG	0.572													16	80					0	0	0.006122	0	0
DNER	92737	broad.mit.edu	37	2	230377608	230377608	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:230377608G>A	uc002vpv.2	-	6	1185	c.1038C>T	c.(1036-1038)TTC>TTT	p.F346F	DNER_uc010zly.1_Silent_p.F74F	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	346	Extracellular (Potential).|EGF-like 3.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		ATTCTTCACAGAAAGTACCCA	0.438													6	23					0	0	0.001168	0	0
DNER	92737	broad.mit.edu	37	2	230411772	230411772	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:230411772G>A	uc002vpv.2	-	5	1031	c.884C>T	c.(883-885)GCT>GTT	p.A295V	DNER_uc010zly.1_Missense_Mutation_p.A23V	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	295	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TAAGCGCAAAGCCACAATAGA	0.443													18	54					0	0	0.004990	0	0
SP140	11262	broad.mit.edu	37	2	231177307	231177307	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:231177307G>A	uc002vql.2	+	27	2627	c.2512G>A	c.(2512-2514)GAT>AAT	p.D838N	SP140_uc010zma.1_Intron|SP140_uc002vqn.2_Missense_Mutation_p.D724N|SP140_uc002vqm.2_Missense_Mutation_p.D778N|SP140_uc010fxl.2_Missense_Mutation_p.D811N	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	838				D -> G (in Ref. 1; AAB18617).	defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TCAGTACAAGGATTTTGGCCA	0.363													10	47					0	0	0.008291	0	0
UGT1A6	54578	broad.mit.edu	37	2	234602351	234602351	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:234602351C>T	uc002vuv.3	+	1	840	c.701C>T	c.(700-702)TCA>TTA	p.S234L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Missense_Mutation_p.S234L	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	234					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		GAACTCGCATCAGCTGTCCTC	0.408													23	129					0	0	0.014323	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638622	234638622	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:234638622A>G	uc002vuy.2	+	1	850	c.850A>G	c.(850-852)AGG>GGG	p.R284G	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.R284G	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	284					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTGTGCCAACAGGAAGCCACT	0.433													4	99					0	0	0.009096	0	0
DNAJB3	414061	broad.mit.edu	37	2	234652431	234652431	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:234652431C>T	uc002vuz.2	-	1	231	c.132G>A	c.(130-132)AGG>AGA	p.R44R	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron	NM_001001394	NP_001001394	Q8WWF6	DNJB3_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 3	44	J.				protein folding		heat shock protein binding|unfolded protein binding				0						GCTTGAATCTCCTCTCCGCTT	0.627													16	152					0	0	0.004990	0	0
TRPM8	79054	broad.mit.edu	37	2	234839327	234839327	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:234839327T>C	uc002vvh.2	+	3	172	c.132T>C	c.(130-132)TTT>TTC	p.F44F	TRPM8_uc010fyj.2_5'UTR|TRPM8_uc002vvi.3_5'UTR|TRPM8_uc002vvj.3_5'UTR	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	44	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TGGTGAATTTTATTCAAGCAA	0.348													3	44					0	0	0.001168	0	0
CXCR7	57007	broad.mit.edu	37	2	237489756	237489756	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:237489756C>T	uc010fyq.2	+	3	878	c.648C>T	c.(646-648)TCC>TCT	p.S216S	CXCR7_uc002vwd.2_Silent_p.S216S	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	216	Helical; Name=5; (Potential).				interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)		AGCTGGTCTCCGTTGTCTTGG	0.572													10	62					0	0	0.006214	0	0
UBE2F	140739	broad.mit.edu	37	2	238881789	238881789	+	Missense_Mutation	SNP	C	T	T	rs139940522		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:238881789C>T	uc002vxk.2	+	2	131	c.40C>T	c.(40-42)CTC>TTC	p.L14F	UBE2F_uc010znn.1_Missense_Mutation_p.L14F|UBE2F_uc002vxl.2_RNA|UBE2F_uc010zno.1_RNA|UBE2F_uc010znp.1_Missense_Mutation_p.L14F|SCLY_uc002vxm.3_5'UTR	NM_080678	NP_542409	Q969M7	UBE2F_HUMAN	NEDD8-conjugating enzyme	14	Interaction with UBA3.				protein neddylation		ATP binding|NEDD8 ligase activity|protein binding				0		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;6.7e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|Kidney(56;3.53e-09)|KIRC - Kidney renal clear cell carcinoma(57;9.79e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000136)|Lung(119;0.0126)|LUSC - Lung squamous cell carcinoma(224;0.0301)		TGACGATGGTCTCAAAGGGTC	0.498													6	49					0	0	0.001168	0	0
C20orf54	113278	broad.mit.edu	37	20	744543	744543	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:744543G>A	uc002wed.3	-	3	1011	c.672C>T	c.(670-672)TTC>TTT	p.F224F	C20orf54_uc002wee.2_Silent_p.F224F	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	224	Helical; (Potential).		F -> L (in BVVLS).		sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						ATAGGAGGAGGAAGAAGACCA	0.607													4	20					0	0	0.000602	0	0
ANGPT4	51378	broad.mit.edu	37	20	896686	896687	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:896686_896687CC>TT	uc002wei.2	-	1	274_275	c.171_172GG>AA	c.(169-174)CCGGGG>CCAAGG	p.G58R	ANGPT4_uc010zpn.1_Missense_Mutation_p.G52R	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	58					anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						ACCTCAGGCCCCGGAGGGCAGG	0.614													15	66					0	0	0.004672	0	0
SIRPB1	10326	broad.mit.edu	37	20	1559323	1559323	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:1559323C>T	uc010gai.2	-	2	193	c.94G>A	c.(94-96)GAG>AAG	p.E32K	SIRPB1_uc002wfk.3_Missense_Mutation_p.E32K	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	32	Extracellular (Potential).|Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						ACCTGTAGCTCGTCCTCACCT	0.507													4	18					0	0	0.009096	0	0
SIRPG	55423	broad.mit.edu	37	20	1616074	1616074	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:1616074G>A	uc002wfm.1	-	4	985	c.920C>T	c.(919-921)ACC>ATC	p.T307I	SIRPG_uc002wfn.1_Intron|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	307	Extracellular (Potential).|Ig-like C1-type 2.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						CCAGTTGTAGGTACCATCCTT	0.542													7	102					0	0	0.003080	0	0
TGM3	7053	broad.mit.edu	37	20	2308780	2308781	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:2308780_2308781GG>AA	uc002wfx.3	+	9	1199_1200	c.1102_1103GG>AA	c.(1102-1104)GGC>AAC	p.G368N		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	368					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	GTTCCAGTGCGGCCCCGCTTCG	0.594													5	56					0	0	0.004672	0	0
TGM6	343641	broad.mit.edu	37	20	2397950	2397950	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:2397950G>A	uc002wfy.1	+	10	1470	c.1409G>A	c.(1408-1410)AGA>AAA	p.R470K	TGM6_uc010gal.1_Missense_Mutation_p.R470K	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	470					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	TCTGGAAGGAGAATCTGGATC	0.627													5	18					0	0	0.001168	0	0
C20orf194	25943	broad.mit.edu	37	20	3278795	3278795	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:3278795G>A	uc002wii.2	-	22	1861	c.1810C>T	c.(1810-1812)CTC>TTC	p.L604F	C20orf194_uc002wij.3_Missense_Mutation_p.L343F|C20orf194_uc002wik.2_Missense_Mutation_p.L278F	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	604											0						AAGTCTATGAGAAGAGCAGCA	0.438													4	35					0	0	0.009096	0	0
HSPA12B	116835	broad.mit.edu	37	20	3728884	3728884	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:3728884G>A	uc002wjd.2	+	8	799	c.696G>A	c.(694-696)GAG>GAA	p.E232E	HSPA12B_uc010zqi.1_Silent_p.E231E|HSPA12B_uc002wje.2_Silent_p.E145E|HSPA12B_uc010zqj.1_Silent_p.E66E	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	232							ATP binding				0						TGTCCCGAGAGAATGCAGAGC	0.662													17	48					0	0	0.007413	0	0
PROKR2	128674	broad.mit.edu	37	20	5282926	5282926	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:5282926G>A	uc010zqw.1	-	2	915	c.915C>T	c.(913-915)TTC>TTT	p.F305F	PROKR2_uc010zqx.1_Silent_p.F305F|PROKR2_uc010zqy.1_Silent_p.F305F	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	305	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TTTCCTTCACGAACACAGTGG	0.537										HNSCC(71;0.22)			9	47					0	0	0.004482	0	0
FERMT1	55612	broad.mit.edu	37	20	6069691	6069691	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:6069691G>A	uc002wmr.2	-	10	1974	c.1185C>T	c.(1183-1185)ATC>ATT	p.I395I	FERMT1_uc002wmq.2_5'UTR|FERMT1_uc010gbt.2_Silent_p.I138I|FERMT1_uc002wms.2_Silent_p.I395I	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	395	PH.|FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3						TGTCTTTAAAGATAAACCAAT	0.348													6	34					0	0	0.001984	0	0
FERMT1	55612	broad.mit.edu	37	20	6077568	6077568	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:6077568C>T	uc002wmr.2	-	8	1859	c.1070G>A	c.(1069-1071)GGA>GAA	p.G357E	FERMT1_uc002wmq.2_5'Flank|FERMT1_uc010gbt.2_Missense_Mutation_p.G100E|FERMT1_uc002wms.2_Missense_Mutation_p.G357E|FERMT1_uc002wmt.2_Missense_Mutation_p.G100E	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	357	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3						GTCCGCTTTTCCACCTTCTAG	0.413													9	150					0	0	0.006214	0	0
FERMT1	55612	broad.mit.edu	37	20	6093246	6093246	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:6093246G>A	uc002wmr.2	-	4	1199	c.410C>T	c.(409-411)TCC>TTC	p.S137F	FERMT1_uc010gbt.2_5'UTR|FERMT1_uc002wms.2_Missense_Mutation_p.S137F	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	137	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3						CTTTAACAAGGAAAGCTCTTC	0.299													9	46					0	0	0.006214	0	0
PLCB1	23236	broad.mit.edu	37	20	8698442	8698442	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:8698442C>T	uc002wnb.2	+	14	1463	c.1460C>T	c.(1459-1461)TCC>TTC	p.S487F	PLCB1_uc010zrb.1_Missense_Mutation_p.S386F|PLCB1_uc002wna.2_Missense_Mutation_p.S487F|PLCB1_uc002wnc.1_Missense_Mutation_p.S386F|PLCB1_uc002wnd.1_Missense_Mutation_p.S64F	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	487					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GAACAAGCCTCCAACACCTAC	0.473													6	22					0	0	0.001984	0	0
PLCB1	23236	broad.mit.edu	37	20	8862357	8862357	+	Missense_Mutation	SNP	G	A	A	rs145966488		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:8862357G>A	uc002wnb.2	+	32	3515	c.3512G>A	c.(3511-3513)GGA>GAA	p.G1171E	PLCB1_uc002wna.2_3'UTR	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	1171					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GCCATGAAAGGAAAGATCAGT	0.512													11	111					0	0	0.008291	0	0
PLCB4	5332	broad.mit.edu	37	20	9417787	9417787	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:9417787G>A	uc002wnf.2	+	28	2852	c.2716G>A	c.(2716-2718)GAA>AAA	p.E906K	PLCB4_uc010gbw.1_Missense_Mutation_p.E906K|PLCB4_uc010gbx.2_Missense_Mutation_p.E918K|PLCB4_uc002wne.2_Missense_Mutation_p.E906K|PLCB4_uc002wnh.2_Missense_Mutation_p.E753K	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	906					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CTCTGGTGTGGAAGCCAAGAA	0.478													10	31					0	0	0.001855	0	0
MKKS	8195	broad.mit.edu	37	20	10394146	10394146	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:10394146G>A	uc002wnt.1	-	3	904	c.17C>T	c.(16-18)GCT>GTT	p.A6V	MKKS_uc002wnu.1_Missense_Mutation_p.A6V|MKKS_uc010zrd.1_Intron	NM_018848	NP_061336	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome protein	6					brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding				0						TGGCTTCTTAGCTTCCAAACG	0.378									Bardet-Biedl_syndrome				10	67					0	0	0.013537	0	0
JAG1	182	broad.mit.edu	37	20	10621793	10621793	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:10621793G>A	uc002wnw.2	-	24	3532	c.3016C>T	c.(3016-3018)CCT>TCT	p.P1006S		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	1006	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						TTCGCTGAAGGGGAAGGCTCG	0.418									Alagille_Syndrome				4	48					0	0	0.009096	0	0
SPTLC3	55304	broad.mit.edu	37	20	13029734	13029734	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:13029734G>A	uc002wod.1	+	2	548	c.259G>A	c.(259-261)GGA>AGA	p.G87R	SPTLC3_uc002woc.2_Missense_Mutation_p.G87R	NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	87					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	AAGAAACTGGGGAATAGAAAA	0.418													4	61					0	0	0.009096	0	0
FLRT3	23767	broad.mit.edu	37	20	14306803	14306803	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:14306803T>C	uc002wov.1	-	3	1817	c.1350A>G	c.(1348-1350)GGA>GGG	p.G450G	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Silent_p.G450G	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	450	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		CTGTTATAGATCCAAATGCCG	0.463													5	50					0	0	0.000602	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665767	19665767	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:19665767G>A	uc002wrl.2	+	12	1283	c.1086G>A	c.(1084-1086)AGG>AGA	p.R362R		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	362	Cytoplasmic (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						TAAACAGCAGGGCTTATACCA	0.517													10	57					0	0	0.002450	0	0
CRNKL1	51340	broad.mit.edu	37	20	20033086	20033086	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:20033086G>A	uc002wrs.2	-	2	416	c.384C>T	c.(382-384)TCC>TCT	p.S128S	C20orf26_uc010gcw.1_5'Flank|C20orf26_uc010zse.1_5'Flank|C20orf26_uc002wru.2_5'Flank|CRNKL1_uc002wrt.1_Silent_p.S116S	NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	128					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						AAAACAAACAGGATCTCGGAA	0.582													7	45					0	0	0.004482	0	0
CD93	22918	broad.mit.edu	37	20	23065369	23065369	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:23065369T>C	uc002wsv.2	-	1	1609	c.1461A>G	c.(1459-1461)GGA>GGG	p.G487G		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	487	Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CTTCTTTCTCTCCTTTGTCCT	0.652													5	38					0	0	0.003080	0	0
CST4	1472	broad.mit.edu	37	20	23669436	23669436	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:23669436C>T	uc002wto.1	-	1	227	c.171G>A	c.(169-171)AAG>AAA	p.K57K		NM_001899	NP_001890	P01036	CYTS_HUMAN	cystatin S precursor	57						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					CTTCGGTGGCCTTGTTGTACT	0.592													10	43					0	0	0.008291	0	0
CST5	1473	broad.mit.edu	37	20	23856866	23856866	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:23856866C>T	uc002wtr.1	-	3	455	c.388G>A	c.(388-390)GAT>AAT	p.D130N		NM_001900	NP_001891	P28325	CYTD_HUMAN	cystatin D precursor	130						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding				0						GAAATTTTATCCTCCCAGGGA	0.478													7	77					0	0	0.006214	0	0
TMEM90B	79953	broad.mit.edu	37	20	24565552	24565552	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:24565552C>T	uc002wtw.1	+	3	1174	c.541C>T	c.(541-543)CAC>TAC	p.H181Y		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	181	Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						CCCGCGGGACCACCTGGGCCT	0.572													10	78					0	0	0.006214	0	0
ACSS1	84532	broad.mit.edu	37	20	24993469	24993469	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:24993469G>A	uc002wub.2	-	11	2564	c.1686C>T	c.(1684-1686)ACC>ACT	p.T562T	ACSS1_uc002wuc.2_Silent_p.T560T|ACSS1_uc010gdc.2_Silent_p.T357T|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Silent_p.T479T	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	562					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CAATCTCTGCGGTCCCCAGCC	0.597													5	54					0	0	0.000602	0	0
PYGB	5834	broad.mit.edu	37	20	25257899	25257899	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:25257899C>T	uc002wup.2	+	7	901	c.792C>T	c.(790-792)ATC>ATT	p.I264I		NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	264					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	GAGACTACATCGAGGCGGTCC	0.562													8	48					0	0	0.006214	0	0
HM13	81502	broad.mit.edu	37	20	30126064	30126064	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:30126064G>A	uc002wwe.2	+	3	479	c.365G>A	c.(364-366)AGC>AAC	p.S122N	HM13_uc002wwc.2_Missense_Mutation_p.S122N|HM13_uc002wwd.2_Missense_Mutation_p.S122N|HM13_uc002wwb.1_Missense_Mutation_p.R122K	NM_030789	NP_110416	Q8TCT9	HM13_HUMAN	minor histocompatibility antigen 13 isoform 1	122	Cytoplasmic (Potential).				membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)	1	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			CACACCATCAGGTCAGAAGGC	0.353													10	49					0	0	0.008291	0	0
TPX2	22974	broad.mit.edu	37	20	30347932	30347932	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:30347932C>T	uc002wwp.1	+	4	877	c.179C>T	c.(178-180)CCT>CTT	p.P60L	TPX2_uc010gdv.1_Missense_Mutation_p.P60L	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	60					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			GGCAAAACTCCTTTGAGAAAG	0.418													22	51					0	0	0.014323	0	0
HCK	3055	broad.mit.edu	37	20	30681801	30681801	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:30681801G>A	uc002wxh.2	+	11	1399	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	HCK_uc010gdy.2_Missense_Mutation_p.E389K|HCK_uc002wxi.2_Missense_Mutation_p.E388K	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	410	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.E389K(1)		lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TGAGGACAACGAGTACACGGC	0.552													6	80					0	0	0.001984	0	0
PLAGL2	5326	broad.mit.edu	37	20	30784883	30784883	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:30784883G>A	uc002wxn.2	-	3	1080	c.863C>T	c.(862-864)GCC>GTC	p.A288V		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	288						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCCAGGGAAGGCCTTGGTCCC	0.607													8	84					0	0	0.003080	0	0
SNTA1	6640	broad.mit.edu	37	20	32005578	32005578	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:32005578G>A	uc002wzd.1	-	3	920	c.648C>T	c.(646-648)TCC>TCT	p.S216S	SNTA1_uc010zuf.1_Silent_p.S216S	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	216	PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						CCATCTTCAAGGACATGTGTT	0.627													6	50					0	0	0.001984	0	0
E2F1	1869	broad.mit.edu	37	20	32268192	32268192	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:32268192G>A	uc002wzu.3	-	2	432	c.292C>T	c.(292-294)CAT>TAT	p.H98Y		NM_005225	NP_005216	Q01094	E2F1_HUMAN	E2F transcription factor 1	98	Cyclin A/CDK2 binding.			KRRLDLETDHQYLAESSGPARGR -> RTPGTPRRQRRLCP PRRPGRAPC (in Ref. 8; AAD14150).	apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding				0						AGGTACTGATGGTCAGTTTCC	0.617													6	41					0	0	0.003080	0	0
NCOA6	23054	broad.mit.edu	37	20	33364247	33364247	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:33364247G>A	uc002xav.2	-	5	2811	c.240C>T	c.(238-240)TCC>TCT	p.S80S	NCOA6_uc002xaw.2_Silent_p.S80S|NCOA6_uc010gew.1_Silent_p.S80S	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	80	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						TTAGCTTGCTGGACTCTTGAT	0.438													8	28					0	0	0.006214	0	0
CEP250	11190	broad.mit.edu	37	20	34095871	34095871	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:34095871G>A	uc002xcm.2	+	33	7429	c.6758G>A	c.(6757-6759)GGA>GAA	p.G2253E	CEP250_uc010zve.1_Missense_Mutation_p.G1621E	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	2253					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CAGGTCTCAGGAGTGGAGGCT	0.552													28	117					0	0	0.010818	0	0
EPB41L1	2036	broad.mit.edu	37	20	34785879	34785879	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:34785879G>A	uc002xfb.2	+	14	1755	c.1584G>A	c.(1582-1584)CGG>CGA	p.R528R	EPB41L1_uc002xeu.2_Silent_p.R454R|EPB41L1_uc010zvo.1_Silent_p.R528R|EPB41L1_uc002xev.2_Silent_p.R528R|EPB41L1_uc002xew.2_Silent_p.R419R|EPB41L1_uc002xex.2_Silent_p.R485R|EPB41L1_uc002xey.2_Silent_p.R443R|EPB41L1_uc002xez.2_Silent_p.R454R|EPB41L1_uc010gfq.2_5'UTR	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	528	Spectrin--actin-binding.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					TCATCCACCGGGATCGAGACT	0.597													4	39					0	0	0.009096	0	0
SAMHD1	25939	broad.mit.edu	37	20	35547860	35547860	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:35547860G>A	uc002xgh.1	-	7	889	c.759C>T	c.(757-759)GTC>GTT	p.V253V		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	253	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				ATTGTTCCATGACAGGCTTAA	0.353													6	37					0	0	0.001168	0	0
KIAA0406	9675	broad.mit.edu	37	20	36631066	36631066	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:36631066G>A	uc002xhl.2	-	5	2825	c.2616C>T	c.(2614-2616)CAC>CAT	p.H872H	KIAA0406_uc002xhm.2_Silent_p.H872H	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	872							binding				0		Myeloproliferative disorder(115;0.00874)				CTGACAACAAGTGGATGCAGC	0.527													15	65					0	0	0.003163	0	0
KIAA0406	9675	broad.mit.edu	37	20	36641063	36641063	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:36641063G>A	uc002xhl.2	-	3	1365	c.1156C>T	c.(1156-1158)CCT>TCT	p.P386S	KIAA0406_uc002xhm.2_Missense_Mutation_p.P386S	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	386							binding				0		Myeloproliferative disorder(115;0.00874)				ATTAGGCGAGGAAGAGATGTG	0.438													14	125					0	0	0.002450	0	0
TGM2	7052	broad.mit.edu	37	20	36776477	36776477	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:36776477G>A	uc002xhr.2	-	5	667	c.567C>T	c.(565-567)ATC>ATT	p.I189I	TGM2_uc010zvx.1_Silent_p.I108I|TGM2_uc010zvy.1_Silent_p.I129I|TGM2_uc002xhs.1_Silent_p.I165I|TGM2_uc002xht.2_Silent_p.I189I|TGM2_uc002xhu.3_Silent_p.I189I	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	189					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	AGATGTCTAGGATCCCATCTT	0.423													7	75					0	0	0.001984	0	0
LBP	3929	broad.mit.edu	37	20	36997702	36997702	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:36997702C>T	uc002xic.1	+	10	1080	c.1045C>T	c.(1045-1047)CTG>TTG	p.L349L		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	349					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding	p.L349M(1)		ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				TGCTCCGCTCCTGAACTTCAG	0.537													20	68					0	0	0.014323	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37536824	37536824	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:37536824G>A	uc002xje.2	+	10	1371	c.1182G>A	c.(1180-1182)GAG>GAA	p.E394E	PPP1R16B_uc010ggc.2_Silent_p.E352E	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	394					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CAGACCAAGAGAATAAGGACC	0.602													4	22					0	0	0.009096	0	0
CHD6	84181	broad.mit.edu	37	20	40118549	40118549	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:40118549G>A	uc002xka.1	-	12	1727	c.1549C>T	c.(1549-1551)CCT>TCT	p.P517S	CHD6_uc002xkd.2_Missense_Mutation_p.P495S	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	517	Helicase ATP-binding.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GTGGAGAGAGGGGCGATAATG	0.507													6	71					0	0	0.001168	0	0
PTPRT	11122	broad.mit.edu	37	20	40770594	40770594	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:40770594C>T	uc002xkg.2	-	18	2915	c.2731G>A	c.(2731-2733)GAA>AAA	p.E911K	PTPRT_uc010ggj.2_Missense_Mutation_p.E930K|PTPRT_uc010ggi.2_Missense_Mutation_p.E114K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	911	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TTGCGGTTTTCATCCTCCTTG	0.507													10	138					0	0	0.013537	0	0
L3MBTL	26013	broad.mit.edu	37	20	42161479	42161479	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:42161479C>T	uc010zwh.1	+	12	1331	c.1285C>T	c.(1285-1287)CTT>TTT	p.L429F	L3MBTL_uc002xkl.2_Missense_Mutation_p.L361F|L3MBTL_uc002xkm.2_Missense_Mutation_p.L361F|L3MBTL_uc010ggl.2_Missense_Mutation_p.L361F|L3MBTL_uc002xkn.1_Missense_Mutation_p.L120F|L3MBTL_uc002xko.2_Missense_Mutation_p.L13F	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	361	MBT 2.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GAACCCGTCCCTTGTCTGCGT	0.597													22	102					0	0	0.002780	0	0
TOX2	84969	broad.mit.edu	37	20	42635225	42635225	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:42635225G>A	uc002xlf.3	+	3	248	c.231G>A	c.(229-231)GAG>GAA	p.E77E	TOX2_uc010ggo.2_Silent_p.E68E|TOX2_uc002xle.3_Silent_p.E26E|TOX2_uc010ggp.2_Silent_p.E26E|TOX2_uc002xlg.2_Silent_p.E26E	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	77	Required for transcriptional activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AAGACTATGAGATCCCCCCGA	0.572													14	50					0	0	0.002450	0	0
WFDC8	90199	broad.mit.edu	37	20	44180689	44180689	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:44180689C>T	uc002xow.2	-	6	781	c.702G>A	c.(700-702)CTG>CTA	p.L234L	WFDC8_uc002xox.2_Silent_p.L234L	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	234	WAP 3.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CCATACATTTCAGTCCACAAT	0.413													8	90					0	0	0.010729	0	0
UBE2C	11065	broad.mit.edu	37	20	44444315	44444315	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:44444315C>T	uc002xpm.2	+	4	432	c.352C>T	c.(352-354)CTG>TTG	p.L118L	UBE2C_uc002xpl.2_Intron|UBE2C_uc002xpn.2_Silent_p.L79L|UBE2C_uc002xpo.2_Silent_p.L89L|UBE2C_uc002xpp.2_Intron|UBE2C_uc002xpq.2_Silent_p.L79L	NM_007019	NP_008950	O00762	UBE2C_HUMAN	ubiquitin-conjugating enzyme E2C isoform 1	118					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|exit from mitosis|free ubiquitin chain polymerization|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|positive regulation of exit from mitosis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|protein K48-linked ubiquitination|spindle organization	anaphase-promoting complex|cytosol|nucleoplasm	ATP binding|protein binding|ubiquitin-protein ligase activity				0		Myeloproliferative disorder(115;0.0122)				CCTGGACATCCTGAAGGAAAA	0.552													6	53					0	0	0.001168	0	0
MMP9	4318	broad.mit.edu	37	20	44637642	44637642	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:44637642C>T	uc002xqz.2	+	1	96	c.77C>T	c.(76-78)TCC>TTC	p.S26F		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	26					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CAGCGCCAGTCCACCCTTGTG	0.627													4	17					0	0	0.000602	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354085	45354085	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:45354085C>T	uc002xsl.2	+	2	507	c.410C>T	c.(409-411)TCC>TTC	p.S137F		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	137	Helical; Name=5; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GTGCTGGTGTCCCTCTATGAG	0.627													10	88					0	0	0.006214	0	0
SULF2	55959	broad.mit.edu	37	20	46294001	46294001	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:46294001C>T	uc002xto.2	-	14	2269	c.1939G>A	c.(1939-1941)GAA>AAA	p.E647K	SULF2_uc002xtr.2_Missense_Mutation_p.E647K|SULF2_uc002xtq.2_Missense_Mutation_p.E647K|SULF2_uc010zyd.1_5'UTR	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	647					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCTCGGACTTCCCTCAGGTTC	0.512													11	133					0	0	0.013537	0	0
PREX1	57580	broad.mit.edu	37	20	47274764	47274764	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:47274764G>A	uc002xtw.1	-	17	1907	c.1884C>T	c.(1882-1884)ATC>ATT	p.I628I	PREX1_uc002xtv.1_5'Flank	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	628	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCTGGGGCAGGATCTGGGGGC	0.662											OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	121					0	0	0.010729	0	0
CSE1L	1434	broad.mit.edu	37	20	47688928	47688928	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:47688928C>T	uc002xty.2	+	9	1008	c.874C>T	c.(874-876)CGT>TGT	p.R292C	CSE1L_uc010zyg.1_Missense_Mutation_p.R75C|CSE1L_uc010ghx.2_Intron|CSE1L_uc010ghy.2_5'UTR|CSE1L_uc010zyh.1_5'Flank	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	292					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			ATACCTGCCTCGTTTTGTTAC	0.398													7	51					0	0	0.003080	0	0
ZNFX1	57169	broad.mit.edu	37	20	47886753	47886753	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:47886753G>A	uc002xui.2	-	3	1843	c.1596C>T	c.(1594-1596)TTC>TTT	p.F532F		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	532							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TATTCCTCTGGAAGGGAACAT	0.502													16	91					0	0	0.007413	0	0
KCNB1	3745	broad.mit.edu	37	20	47990438	47990438	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:47990438C>T	uc002xur.1	-	2	1823	c.1659G>A	c.(1657-1659)CAG>CAA	p.Q553Q	KCNB1_uc002xus.1_Silent_p.Q553Q	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	553	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TTGGTTTGCTCTGTGCTGCTG	0.512													12	121					0	0	0.013537	0	0
KCNB1	3745	broad.mit.edu	37	20	47990999	47990999	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:47990999G>A	uc002xur.1	-	2	1262	c.1098C>T	c.(1096-1098)GCC>GCT	p.A366A	KCNB1_uc002xus.1_Silent_p.A366A	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	366					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ACCAGAAAGAGGCTGGGATGC	0.507													5	57					0	0	0.000602	0	0
KCNB1	3745	broad.mit.edu	37	20	47991332	47991332	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:47991332C>T	uc002xur.1	-	2	929	c.765G>A	c.(763-765)TGG>TGA	p.W255*	KCNB1_uc002xus.1_Nonsense_Mutation_p.W255*	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	255	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGAAGAACTTCCACTTCTTGG	0.542													5	28					0	0	0.001168	0	0
PTGIS	5740	broad.mit.edu	37	20	48130782	48130782	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:48130782C>T	uc002xut.2	-	7	1060	c.1006G>A	c.(1006-1008)GAC>AAC	p.D336N	PTGIS_uc010zyi.1_Missense_Mutation_p.D197N	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	336					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	GGTGTGCTGTCTAGAACCTTC	0.587													5	50					0	0	0.000602	0	0
ATP9A	10079	broad.mit.edu	37	20	50305663	50305663	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:50305663G>A	uc002xwg.1	-	9	739	c.739C>T	c.(739-741)CCG>TCG	p.P247S	ATP9A_uc010gih.1_Intron|ATP9A_uc002xwf.1_5'UTR	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	247	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TCGCTGATCGGGGGGTCGCTG	0.557													32	96					0	0	0.013726	0	0
SALL4	57167	broad.mit.edu	37	20	50418921	50418921	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:50418921G>A	uc002xwh.3	-	1	128	c.27C>T	c.(25-27)CCC>CCT	p.P9P	SALL4_uc010gii.2_Silent_p.P9P|SALL4_uc002xwi.3_Silent_p.P9P	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	9					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGATGTGCTGGGGTTTCGCCT	0.537													5	49					0	0	0.001984	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870774	51870774	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:51870774G>A	uc002xwo.2	+	2	1733	c.777G>A	c.(775-777)AGG>AGA	p.R259R		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	259					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CAAAGCCCAGGAAAAGGGCTT	0.478													5	28					0	0	0.000602	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871503	51871503	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:51871503G>A	uc002xwo.2	+	2	2462	c.1506G>A	c.(1504-1506)AGG>AGA	p.R502R		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	502					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AATACCTAAGGGAGGAAGACT	0.448													6	43					0	0	0.003080	0	0
CYP24A1	1591	broad.mit.edu	37	20	52774093	52774093	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:52774093C>T	uc002xwv.2	-	10	1666	c.1268G>A	c.(1267-1269)GGA>GAA	p.G423E	CYP24A1_uc002xwu.1_Missense_Mutation_p.G281E|CYP24A1_uc002xww.2_Intron	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	423					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	TTCACTGGATCCCAACACCTG	0.393													6	62					0	0	0.001984	0	0
DOK5	55816	broad.mit.edu	37	20	53171574	53171574	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:53171574C>T	uc002xwy.2	+	2	389	c.169C>T	c.(169-171)CAT>TAT	p.H57Y	DOK5_uc010gin.2_5'UTR|DOK5_uc002xwz.2_5'UTR	NM_018431	NP_060901	Q9P104	DOK5_HUMAN	docking protein 5	57	PH.						insulin receptor binding			ovary(1)	1			Colorectal(105;0.202)			CAGGTGTTATCATAAGGTAAG	0.373													7	21					0	0	0.004482	0	0
MC3R	4159	broad.mit.edu	37	20	54824538	54824538	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:54824538T>G	uc002xxb.2	+	1	751	c.639T>G	c.(637-639)TTT>TTG	p.F213L		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	250	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			TGTTCCTCTTTGCGCGGCTGC	0.572													4	42					0	0	0.009096	0	0
CASS4	57091	broad.mit.edu	37	20	55033445	55033445	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:55033445G>A	uc002xxp.2	+	7	2228	c.2003G>A	c.(2002-2004)AGG>AAG	p.R668K	CASS4_uc002xxr.2_Missense_Mutation_p.R668K|CASS4_uc010zze.1_Missense_Mutation_p.R614K|CASS4_uc010gio.2_Missense_Mutation_p.R231K	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	668					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						ACTCCTGAGAGGAAACCCCGC	0.532													6	44					0	0	0.001984	0	0
PCK1	5105	broad.mit.edu	37	20	56137864	56137864	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:56137864G>A	uc002xyn.3	+	4	682	c.519G>A	c.(517-519)ATG>ATA	p.M173I	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	173					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TGCGGATCATGACGCGGATGG	0.587													5	26					0	0	0.001984	0	0
PCK1	5105	broad.mit.edu	37	20	56139563	56139563	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:56139563G>A	uc002xyn.3	+	8	1375	c.1212G>A	c.(1210-1212)TCG>TCA	p.S404S	PCK1_uc010zzm.1_Silent_p.S87S	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	404	Substrate binding.				gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			ACCCCAACTCGAGGTTCTGCA	0.587													15	66					0	0	0.004990	0	0
GNAS	2778	broad.mit.edu	37	20	57474005	57474005	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:57474005A>T	uc002xzw.2	+	3	2436	c.2151A>T	c.(2149-2151)GAA>GAT	p.E717D	GNAS_uc002xzt.2_3'UTR|GNAS_uc002xzu.3_RNA|GNAS_uc010gjq.2_Missense_Mutation_p.E15D|GNAS_uc002xzv.2_RNA|GNAS_uc002xzx.2_Missense_Mutation_p.E15D|GNAS_uc010gjr.2_Intron|GNAS_uc002xzy.2_Intron|GNAS_uc002yaa.2_Intron|GNAS_uc010zzt.1_Missense_Mutation_p.E74D|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Translation_Start_Site	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	74					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GGGGCGGCGAAGAGGACCCGC	0.473			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			17	86					0	0	0.006122	0	0
CTSZ	1522	broad.mit.edu	37	20	57581453	57581453	+	Silent	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:57581453G>C	uc002yai.2	-	2	357	c.231C>G	c.(229-231)GCC>GCG	p.A77A	CTSZ_uc002yaj.3_Silent_p.A77A	NM_001336	NP_001327	Q9UBR2	CATZ_HUMAN	cathepsin Z preproprotein	77					proteolysis	endoplasmic reticulum|extracellular space|lysosome	cysteine-type endopeptidase activity			kidney(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)			GGGTGATGCTGGCATAGTTGA	0.622													4	43					0	0	0.009096	0	0
CDH26	60437	broad.mit.edu	37	20	58567522	58567522	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:58567522C>T	uc002ybe.2	+	10	1673	c.1373C>T	c.(1372-1374)TCC>TTC	p.S458F	CDH26_uc002ybf.1_Missense_Mutation_p.S38F|CDH26_uc010zzy.1_RNA|CDH26_uc002ybg.2_5'Flank	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	458	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GACCGAGAATCCCCTCATGTA	0.413													6	25					0	0	0.001984	0	0
CDH4	1002	broad.mit.edu	37	20	60448930	60448930	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:60448930A>C	uc002ybn.1	+	7	1038	c.1024A>C	c.(1024-1026)ACA>CCA	p.T342P	CDH4_uc002ybp.1_Missense_Mutation_p.T268P	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	342	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			AGATATCGTCACAGTGGCGGC	0.662													5	52					0	0	0.000602	0	0
CDH4	1002	broad.mit.edu	37	20	60504876	60504876	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:60504876C>T	uc002ybn.1	+	13	2229	c.2215C>T	c.(2215-2217)CTC>TTC	p.L739F	CDH4_uc002ybp.1_Missense_Mutation_p.L665F	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	739	Helical; (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CGTGGCCATCCTCATCTGCAT	0.617													7	40					0	0	0.003080	0	0
TAF4	6874	broad.mit.edu	37	20	60582625	60582625	+	Missense_Mutation	SNP	G	A	A	rs6089604		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:60582625G>A	uc002ybs.2	-	6	1952	c.1952C>T	c.(1951-1953)CCT>CTT	p.P651L		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	651	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			CACAAGGTAAGGTTGAGGTGA	0.478													10	106					0	0	0.008291	0	0
DIDO1	11083	broad.mit.edu	37	20	61525227	61525227	+	Silent	SNP	G	A	A	rs111520535	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:61525227G>A	uc002ydr.1	-	12	3156	c.2892C>T	c.(2890-2892)TCC>TCT	p.S964S	DIDO1_uc002yds.1_Silent_p.S964S|DIDO1_uc002ydt.1_Silent_p.S964S|DIDO1_uc002ydu.1_Silent_p.S964S	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	964					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GGTCCCGGCCGGACACTGTGA	0.687													5	48					0	0	0.001168	0	0
DIDO1	11083	broad.mit.edu	37	20	61528327	61528327	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:61528327G>A	uc002ydr.1	-	7	1874	c.1610C>T	c.(1609-1611)TCC>TTC	p.S537F	DIDO1_uc002yds.1_Missense_Mutation_p.S537F|DIDO1_uc002ydt.1_Missense_Mutation_p.S537F|DIDO1_uc002ydu.1_Missense_Mutation_p.S537F	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	537					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TTTCTCCTCGGACCTCCTGTC	0.567													4	27					0	0	0.000602	0	0
COL20A1	57642	broad.mit.edu	37	20	61957467	61957467	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr20:61957467G>A	uc011aau.1	+	30	3522	c.3422G>A	c.(3421-3423)GGA>GAA	p.G1141E	COL20A1_uc011aav.1_Missense_Mutation_p.G962E	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1141	Collagen-like 2.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					GGCCTGGAGGGAACTGCTGGC	0.662													6	52					0	0	0.003080	0	0
TPTE	7179	broad.mit.edu	37	21	10920131	10920131	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:10920131C>T	uc002yip.1	-	19	1491	c.1123G>A	c.(1123-1125)GAT>AAT	p.D375N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.D357N|TPTE_uc002yir.1_Missense_Mutation_p.D337N|TPTE_uc010gkv.1_Missense_Mutation_p.D237N	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	375	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGGGTTTTATCTGTTCGCCTT	0.383													4	42					0	0	0.000602	0	0
TPTE	7179	broad.mit.edu	37	21	10951266	10951266	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:10951266C>T	uc002yip.1	-	10	814	c.446G>A	c.(445-447)AGG>AAG	p.R149K	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.R131K|TPTE_uc002yir.1_Missense_Mutation_p.R111K|TPTE_uc010gkv.1_Missense_Mutation_p.R11K	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	149					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCAAACTTACCTTTCTACAAA	0.224													5	49					0	0	0.001168	0	0
TPTE	7179	broad.mit.edu	37	21	10951294	10951294	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:10951294C>T	uc002yip.1	-	10	786	c.418G>A	c.(418-420)GAT>AAT	p.D140N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.D122N|TPTE_uc002yir.1_Missense_Mutation_p.D102N|TPTE_uc010gkv.1_Missense_Mutation_p.D2N	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	140	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGAAGAACATCCATGAGAAAA	0.289													6	76					0	0	0.001984	0	0
TPTE	7179	broad.mit.edu	37	21	10970043	10970043	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:10970043T>A	uc002yip.1	-	6	453	c.85A>T	c.(85-87)AAA>TAA	p.K29*	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Nonsense_Mutation_p.K29*|TPTE_uc002yir.1_Nonsense_Mutation_p.K29*|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	29					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTTGCTCCTTTAAATTCACTT	0.388													12	157					0	0	0.002450	0	0
LIPI	149998	broad.mit.edu	37	21	15524928	15524928	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:15524928G>A	uc002yjm.2	-	8	1157	c.1147C>T	c.(1147-1149)CAG>TAG	p.Q383*		NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	362					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		ATTCCAAGCTGATTTAATAAT	0.284													4	28					0	0	0.000602	0	0
BTG3	10950	broad.mit.edu	37	21	18966470	18966470	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:18966470G>A	uc002ykk.2	-	5	960	c.700C>T	c.(700-702)CCT>TCT	p.P234S	BTG3_uc002ykl.2_Missense_Mutation_p.P278S	NM_006806	NP_006797	Q14201	BTG3_HUMAN	B-cell translocation gene 3 isoform b	234					negative regulation of cell proliferation|negative regulation of mitotic cell cycle	cytoplasm					0				Epithelial(23;0.000283)|all cancers(11;0.0012)|Lung(58;0.0191)|OV - Ovarian serous cystadenocarcinoma(11;0.0206)|COAD - Colon adenocarcinoma(22;0.0315)|LUSC - Lung squamous cell carcinoma(23;0.0703)|Colorectal(24;0.0971)		TGCATTCCAGGAGGAGGTACC	0.423													8	38					0	0	0.003080	0	0
CHODL	140578	broad.mit.edu	37	21	19629030	19629030	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:19629030C>T	uc002ykv.2	+	2	675	c.284C>T	c.(283-285)TCT>TTT	p.S95F	CHODL_uc002ykr.2_Missense_Mutation_p.S54F|CHODL_uc002yks.2_Missense_Mutation_p.S54F|CHODL_uc002ykt.2_Missense_Mutation_p.S54F|CHODL_uc002yku.2_Missense_Mutation_p.S54F	NM_024944	NP_079220	Q9H9P2	CHODL_HUMAN	chondrolectin precursor	95	Extracellular (Potential).|C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			upper_aerodigestive_tract(1)	1		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		ACAGGGATTTCTGATGGTGAT	0.498													13	81					0	0	0.002450	0	0
JAM2	58494	broad.mit.edu	37	21	27071133	27071133	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:27071133G>A	uc002ylp.1	+	5	1084	c.539G>A	c.(538-540)AGA>AAA	p.R180K	JAM2_uc011ace.1_Missense_Mutation_p.R180K|JAM2_uc002ylq.1_RNA|JAM2_uc011acf.1_Missense_Mutation_p.R144K|JAM2_uc010glh.1_RNA|JAM2_uc002ylr.1_Missense_Mutation_p.R180K|JAM2_uc010gli.1_Missense_Mutation_p.R180K	NM_021219	NP_067042	P57087	JAM2_HUMAN	junctional adhesion molecule 2 precursor	180	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction					0						GAAAATCCCAGACTTGGCTCC	0.423													5	30					0	0	0.001168	0	0
RNF160	26046	broad.mit.edu	37	21	30339281	30339281	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:30339281G>A	uc002ymr.2	-	10	1683	c.1670C>T	c.(1669-1671)TCC>TTC	p.S557F	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	511							ligase activity|zinc ion binding				0						ACCCAAAACGGACTCAACATC	0.408													5	85					0	0	0.000602	0	0
BACH1	571	broad.mit.edu	37	21	30698863	30698863	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:30698863C>T	uc002ynj.2	+	3	833	c.718C>T	c.(718-720)CGT>TGT	p.R240C	BACH1_uc002ynk.2_Missense_Mutation_p.R240C|BACH1_uc002ynl.2_RNA	NM_001186	NP_001177	O14867	BACH1_HUMAN	BTB and CNC homology 1 transcription factor	240						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|liver(1)	2						TGACAGAGTCCGTACTGGGGA	0.443													10	42					0	0	0.006214	0	0
KRTAP13-3	337960	broad.mit.edu	37	21	31798068	31798068	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:31798068C>T	uc002yob.1	-	1	163	c.163G>A	c.(163-165)GGC>AGC	p.G55S		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	55	1.|5 X 10 AA approximate repeats.					intermediate filament				ovary(1)|lung(1)	2						TCCTGACAGCCCCTATAGAGA	0.602													6	42					0	0	0.001168	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812806	31812806	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:31812806C>T	uc002yod.2	+	1	161	c.161C>T	c.(160-162)ACC>ATC	p.T54I		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	54						intermediate filament					0						TGTCAGGAGACCTACTGTGAG	0.498													8	81					0	0	0.003080	0	0
KRTAP19-5	337972	broad.mit.edu	37	21	31874269	31874269	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:31874269C>T	uc011ada.1	-	1	140	c.140G>A	c.(139-141)GGC>GAC	p.G47D		NM_181611	NP_853642	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	47						intermediate filament	protein binding				0						GAAGCCAGAGCCGTATCCGTA	0.552													7	70					0	0	0.003080	0	0
SFRS15	57466	broad.mit.edu	37	21	33060763	33060763	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:33060763G>A	uc002ypd.2	-	16	2326	c.1900C>T	c.(1900-1902)CCT>TCT	p.P634S	SFRS15_uc002ype.2_Missense_Mutation_p.P634S|SFRS15_uc010glu.2_Missense_Mutation_p.P619S|SFRS15_uc002ypf.1_Missense_Mutation_p.P308S	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	634						nucleus	nucleotide binding|RNA binding				0						GGCTTCTTAGGAATTCCTTTC	0.363													6	81					0	0	0.003080	0	0
SFRS15	57466	broad.mit.edu	37	21	33067281	33067281	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:33067281G>A	uc002ypd.2	-	10	1507	c.1081C>T	c.(1081-1083)CCT>TCT	p.P361S	SFRS15_uc002ype.2_Missense_Mutation_p.P361S|SFRS15_uc010glu.2_Missense_Mutation_p.P346S|SFRS15_uc002ypf.1_Missense_Mutation_p.P35S	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	361						nucleus	nucleotide binding|RNA binding				0						TGTCCATTAGGAGGAAGTGGA	0.383													4	38					0	0	0.009096	0	0
HUNK	30811	broad.mit.edu	37	21	33371035	33371035	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:33371035C>T	uc002yph.2	+	11	2043	c.1683C>T	c.(1681-1683)TCC>TCT	p.S561S		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	561					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						TGGTGCGCTCCTTCGAGTCTG	0.592													4	25					0	0	0.009096	0	0
C21orf59	56683	broad.mit.edu	37	21	33954539	33954539	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:33954539G>A	uc002ypy.1	-	7	1062	c.949C>T	c.(949-951)CCA>TCA	p.P317S	TCP10L_uc002ypw.3_Missense_Mutation_p.P111S|C21orf59_uc002ypx.1_Missense_Mutation_p.P134S|C21orf59_uc002ypz.1_Missense_Mutation_p.P285S	NM_021254	NP_067077	P57076	CU059_HUMAN	hypothetical protein LOC56683	Error:Variant_position_missing_in_P57076_after_alignment						cytosol|nucleus					0						CCCGCGTGTGGGGACGCTGCA	0.498													9	104					0	0	0.010729	0	0
GART	2618	broad.mit.edu	37	21	34889714	34889714	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:34889714G>A	uc002yrx.2	-	15	2039	c.1904C>T	c.(1903-1905)TCC>TTC	p.S635F	GART_uc002yrz.2_Missense_Mutation_p.S635F|GART_uc010gmd.2_Missense_Mutation_p.S297F|GART_uc002yry.2_Missense_Mutation_p.S635F	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	635	AIRS.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	GTACTGGAGGGAAGATTTTGC	0.458													9	71					0	0	0.006214	0	0
ITSN1	6453	broad.mit.edu	37	21	35138184	35138184	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:35138184T>C	uc002yta.1	+	10	1062	c.794T>C	c.(793-795)CTT>CCT	p.L265P	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.L265P|ITSN1_uc010gmg.2_Missense_Mutation_p.L228P|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.L265P|ITSN1_uc010gmi.2_Missense_Mutation_p.L228P|ITSN1_uc010gmj.2_Missense_Mutation_p.L149P|ITSN1_uc002ysy.2_Missense_Mutation_p.L265P|ITSN1_uc002ysx.2_Missense_Mutation_p.L228P|ITSN1_uc002ytb.1_Missense_Mutation_p.L265P|ITSN1_uc002ytc.1_Missense_Mutation_p.L265P|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.L228P|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.L265P|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.L199P	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	265	EF-hand 2.|EH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						AATAGGAATCTTTCTGACATT	0.358													4	39					0	0	0.009096	0	0
DOPEY2	9980	broad.mit.edu	37	21	37605195	37605196	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:37605195_37605196CC>TT	uc002yvg.2	+	15	2523_2524	c.2444_2445CC>TT	c.(2443-2445)TCC>TTT	p.S815F	DOPEY2_uc011aeb.1_Missense_Mutation_p.S815F	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	815					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						GTGGCCATTTCCACTCTGCTGG	0.485													10	77					0	0	0.004672	0	0
MORC3	23515	broad.mit.edu	37	21	37717257	37717257	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:37717257T>C	uc002yvi.2	+	8	1009	c.933T>C	c.(931-933)GAT>GAC	p.D311D		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	311					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						GAAATAAAGATCATTATGGGA	0.294													5	37					0	0	0.001168	0	0
ERG	2078	broad.mit.edu	37	21	39755711	39755711	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:39755711C>T	uc010gnw.2	-	12	1370	c.1075G>A	c.(1075-1077)GGA>AGA	p.G359R	ERG_uc002yxa.2_Missense_Mutation_p.G352R|ERG_uc011aek.1_Missense_Mutation_p.G260R|ERG_uc010gnv.2_Missense_Mutation_p.G236R|ERG_uc010gnx.2_Missense_Mutation_p.G335R|ERG_uc011ael.1_Missense_Mutation_p.G359R|ERG_uc002yxb.2_Missense_Mutation_p.G335R	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	359	ETS.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				TTCCGCTCTCCCCAGCGCCGG	0.587													8	49					0	0	0.004482	0	0
PCP4	5121	broad.mit.edu	37	21	41300986	41300986	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:41300986C>T	uc002yyp.2	+	3	220	c.139C>T	c.(139-141)CAG>TAG	p.Q47*		NM_006198	NP_006189	P48539	PCP4_HUMAN	Purkinje cell protein 4	47	IQ.				central nervous system development	cytosol|nucleus				large_intestine(1)	1		Prostate(19;2.65e-06)|all_epithelial(19;0.138)				GGTGGCCATTCAGTCTCAGTT	0.458													6	29					0	0	0.001168	0	0
DSCAM	1826	broad.mit.edu	37	21	41459205	41459205	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:41459205C>T	uc002yyq.1	-	22	4312	c.3860G>A	c.(3859-3861)CGA>CAA	p.R1287Q	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1287	Extracellular (Potential).|Ig-like C2-type 10.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGTCAGGATTCGTGCAGGAGC	0.483													6	79					0	0	0.001984	0	0
RIPK4	54101	broad.mit.edu	37	21	43161260	43161260	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:43161260G>A	uc002yzn.1	-	8	2141	c.2093C>T	c.(2092-2094)GCC>GTC	p.A698V		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	698						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GGGTCCCCGGGCCAGCACATC	0.662													15	54					0	0	0.004007	0	0
UMODL1	89766	broad.mit.edu	37	21	43504230	43504230	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:43504230G>A	uc002zaf.1	+	3	356	c.356G>A	c.(355-357)GGG>GAG	p.G119E	UMODL1_uc002zad.1_Missense_Mutation_p.G47E|UMODL1_uc002zae.1_Missense_Mutation_p.G47E|UMODL1_uc002zag.1_Missense_Mutation_p.G119E|UMODL1_uc010gow.1_5'Flank|UMODL1_uc002zai.1_5'Flank|UMODL1_uc010gox.1_5'Flank|UMODL1_uc010goy.1_5'Flank|UMODL1_uc002zaj.1_5'Flank|UMODL1_uc010goz.1_5'Flank	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	119	Extracellular (Potential).|WAP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TCAAGACCTGGGGCCTGCCCC	0.577													13	109					0	0	0.002450	0	0
UBASH3A	53347	broad.mit.edu	37	21	43838637	43838637	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:43838637C>T	uc002zbe.2	+	7	1001	c.965C>T	c.(964-966)TCA>TTA	p.S322L	UBASH3A_uc002zbf.2_Missense_Mutation_p.S284L|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.S284L	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	322	SH3.					cytosol|nucleus				ovary(3)	3						ATTGGGATCTCACAGCGGACG	0.612													9	33					0	0	0.006214	0	0
PDE9A	5152	broad.mit.edu	37	21	44171236	44171237	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:44171236_44171237CC>TT	uc002zbm.2	+	9	727_728	c.664_665CC>TT	c.(664-666)CCC>TTC	p.P222F	PDE9A_uc002zbn.2_Missense_Mutation_p.P95F|PDE9A_uc002zbo.2_Missense_Mutation_p.P169F|PDE9A_uc002zbp.2_Missense_Mutation_p.P15F|PDE9A_uc002zbq.2_Missense_Mutation_p.P120F|PDE9A_uc002zbs.2_Missense_Mutation_p.P15F|PDE9A_uc002zbr.2_Missense_Mutation_p.P15F|PDE9A_uc002zbt.2_Missense_Mutation_p.P94F|PDE9A_uc002zbu.2_Missense_Mutation_p.P88F|PDE9A_uc002zbv.2_Missense_Mutation_p.P62F|PDE9A_uc002zbw.2_Missense_Mutation_p.P5F|PDE9A_uc002zbx.2_Missense_Mutation_p.P162F|PDE9A_uc002zby.2_Missense_Mutation_p.P5F|PDE9A_uc002zbz.2_Missense_Mutation_p.P114F|PDE9A_uc002zca.2_Missense_Mutation_p.P181F|PDE9A_uc002zcb.2_Missense_Mutation_p.P196F|PDE9A_uc002zcc.2_Missense_Mutation_p.P121F|PDE9A_uc002zcd.2_Missense_Mutation_p.P136F|PDE9A_uc002zce.2_Missense_Mutation_p.P155F|PDE9A_uc002zcf.2_Missense_Mutation_p.P15F|PDE9A_uc002zcg.2_Missense_Mutation_p.P15F|PDE9A_uc002zch.2_Missense_Mutation_p.P5F|PDE9A_uc010gpf.1_Missense_Mutation_p.P15F	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	222					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						GACCAACTGCCCCTGTAAGTAC	0.51													10	206					0	0	0.004672	0	0
PKNOX1	5316	broad.mit.edu	37	21	44441539	44441540	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:44441539_44441540GG>AA	uc002zcq.1	+	8	1035_1036	c.847_848GG>AA	c.(847-849)GGG>AAG	p.G283K	PKNOX1_uc002zcp.1_Missense_Mutation_p.G283K|PKNOX1_uc011aex.1_Missense_Mutation_p.G166K	NM_004571	NP_004562	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1	283	Homeobox; TALE-type.						sequence-specific DNA binding			large_intestine(2)	2						CCAGCACATCGGGGTAAGGACG	0.554													9	48					0	0	0.004672	0	0
SIK1	150094	broad.mit.edu	37	21	44837515	44837515	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:44837515G>A	uc002zdf.2	-	13	2011	c.1884C>T	c.(1882-1884)TTC>TTT	p.F628F		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	628					anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						CAGGGGCGTGGAAGGGGCTCA	0.711													4	10					0	0	0.009096	0	0
HSF2BP	11077	broad.mit.edu	37	21	44949752	44949752	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:44949752A>T	uc002zdi.2	-	9	1219	c.887T>A	c.(886-888)TTC>TAC	p.F296Y	HSF2BP_uc011aey.1_Missense_Mutation_p.F221Y	NM_007031	NP_008962	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding	296					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.18)		GGAGCTCCGGAACTCAGAGGC	0.582													5	61					0	0	0.001984	0	0
TRPM2	7226	broad.mit.edu	37	21	45799023	45799023	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:45799023C>T	uc002zet.1	+	9	1371	c.1158C>T	c.(1156-1158)TTC>TTT	p.F386F	TRPM2_uc002zeu.1_Silent_p.F386F|TRPM2_uc002zew.1_Silent_p.F386F|TRPM2_uc010gpt.1_Silent_p.F386F|TRPM2_uc002zex.1_Silent_p.F172F	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	386	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGAGCGTGTTCTTCCAGGAGA	0.582													5	63					0	0	0.001168	0	0
TRPM2	7226	broad.mit.edu	37	21	45810858	45810858	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:45810858C>T	uc002zet.1	+	11	1603	c.1390C>T	c.(1390-1392)CGC>TGC	p.R464C	TRPM2_uc002zeu.1_Missense_Mutation_p.R464C|TRPM2_uc002zew.1_Missense_Mutation_p.R464C|TRPM2_uc010gpt.1_Missense_Mutation_p.R464C|TRPM2_uc002zex.1_Missense_Mutation_p.R250C|TRPM2_uc002zey.1_5'Flank	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	464	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCATGGAATCGCGTGGACAT	0.577													10	61					0	0	0.010729	0	0
TRPM2	7226	broad.mit.edu	37	21	45833940	45833940	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:45833940C>T	uc002zet.1	+	21	3342	c.3129C>T	c.(3127-3129)CTC>CTT	p.L1043L	TRPM2_uc002zeu.1_Silent_p.L1043L|TRPM2_uc002zew.1_Silent_p.L1043L|TRPM2_uc010gpt.1_Silent_p.L1043L|TRPM2_uc002zex.1_Silent_p.L829L|TRPM2_uc002zey.1_Silent_p.L556L	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1043	Helical; (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGCTCAACCTCCTCATCGCCA	0.657													14	165					0	0	0.004007	0	0
C21orf29	54084	broad.mit.edu	37	21	45950943	45950943	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:45950943C>G	uc002zfe.1	-	4	682	c.616G>C	c.(616-618)GCC>CCC	p.A206P	C21orf29_uc010gpv.1_Missense_Mutation_p.A138P	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	206	TSP N-terminal.				cell adhesion	extracellular region	structural molecule activity				0						AGGCCTTTGGCTCTCCTCCGG	0.577													3	32					0	0	0.004672	0	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032776	46032776	+	Silent	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:46032776G>C	uc002zfo.1	+	1	781	c.759G>C	c.(757-759)GCG>GCC	p.A253A	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198695	NP_941968	P60410	KR108_HUMAN	keratin associated protein 10-8	253						keratin filament				large_intestine(1)|breast(1)	2						gccgccccgcgtgctcccgcc	0.284													4	15					0	0	0.009096	0	0
KRTAP12-4	386684	broad.mit.edu	37	21	46074299	46074299	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:46074299G>A	uc002zfs.1	-	1	278	c.233C>T	c.(232-234)CCT>CTT	p.P78L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198698	NP_941971	P60329	KR124_HUMAN	keratin associated protein 12-4	78	15 X 5 AA approximate repeats.|11.					keratin filament				ovary(1)	1						ACACAAAACAGGCTTGCAGCT	0.652													4	30					0	0	0.009096	0	0
ADARB1	104	broad.mit.edu	37	21	46624512	46624512	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr21:46624512C>T	uc002zgy.2	+	10	2163	c.1728C>T	c.(1726-1728)TTC>TTT	p.F576F	ADARB1_uc002zgr.2_Silent_p.F576F|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Silent_p.F536F|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Silent_p.F536F|ADARB1_uc010gpx.2_RNA|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	576	A to I editase.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		TCAGCATTTTCGTGGAGCCCA	0.582													19	45					0	0	0.012319	0	0
POTEH	23784	broad.mit.edu	37	22	16287402	16287402	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:16287402C>T	uc010gqp.2	-	1	536	c.484G>A	c.(484-486)GAC>AAC	p.D162N	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_5'UTR|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	162										skin(1)	1						AAAGCGCTGTCGTCGTAGTCT	0.587													9	126					0	0	0.008291	0	0
XKR3	150165	broad.mit.edu	37	22	17280726	17280726	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:17280726G>A	uc002zlv.2	-	3	622	c.524C>T	c.(523-525)TCT>TTT	p.S175F	XKR3_uc011agf.1_Missense_Mutation_p.S175F	NM_175878	NP_787074	Q5GH77	XKR3_HUMAN	X Kell blood group precursor-related family,	175	Helical; (Potential).					integral to membrane|plasma membrane				large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TTGTGGAACAGAACCGAGAAA	0.403													34	90					0	0	0.012213	0	0
CECR6	27439	broad.mit.edu	37	22	17601081	17601081	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:17601081A>C	uc002zmb.2	-	1	1133	c.937T>G	c.(937-939)TTC>GTC	p.F313V	CECR6_uc002zma.2_Intron|uc002zmc.2_5'Flank	NM_031890	NP_114096	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	313	Ala-rich.										0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		AGGTAGGCGAAGGCGAACTCG	0.453													6	51					0	0	0.001168	0	0
SLC25A18	83733	broad.mit.edu	37	22	18066228	18066228	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:18066228G>A	uc002zmp.1	+	7	831	c.337G>A	c.(337-339)GGG>AGG	p.G113R	SLC25A18_uc010gqx.2_Missense_Mutation_p.G113R|SLC25A18_uc002zmq.1_Missense_Mutation_p.G113R	NM_031481	NP_113669	Q9H1K4	GHC2_HUMAN	solute carrier	113	Helical; Name=3; (Potential).|Solcar 2.					integral to membrane|mitochondrial inner membrane	binding|symporter activity				0				Lung(27;0.124)	L-Glutamic Acid(DB00142)	GTGTGGGGCTGGGATGTGCCA	0.622													8	74					0	0	0.003080	0	0
Unknown	0	broad.mit.edu	37	22	18844973	18844973	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:18844973G>A	uc002zoe.2	+	4		c.2227G>A			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		AAAGAGCACGGAAATGCAGCG	0.577													11	47					0	0	0.013537	0	0
CLTCL1	8218	broad.mit.edu	37	22	19197869	19197869	+	Silent	SNP	G	A	A	rs36059037		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:19197869G>A	uc002zpb.2	-	20	3291	c.3216C>T	c.(3214-3216)TTC>TTT	p.F1072F	CLTCL1_uc011agv.1_Silent_p.F1072F|CLTCL1_uc011agw.1_Silent_p.F1072F|CLTCL1_uc011agt.1_5'Flank|CLTCL1_uc011agu.1_5'Flank|CLTCL1_uc010grm.1_5'Flank|CLTCL1_uc002zpe.2_Silent_p.F32F|CLTCL1_uc002zpd.1_Silent_p.F32F	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1072	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					CAAACTTGTGGAAAACGGTGA	0.552			T	?	ALCL								16	57					0	0	0.006122	0	0
SEPT5	5413	broad.mit.edu	37	22	19707342	19707342	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:19707342G>A	uc002zpv.1	+	4	290	c.165G>A	c.(163-165)CTG>CTA	p.L55L	SEPT5_uc002zpw.1_RNA|SEPT5_uc002zpx.1_RNA|SEPT5_uc002zpy.1_5'Flank	NM_002688	NP_002679	Q99719	SEPT5_HUMAN	septin 5	55	GTP (By similarity).				cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)	1	Colorectal(54;0.0993)					AGTCAGGCCTGGGGAAGTCCA	0.627													14	93					0	0	0.007413	0	0
SCARF2	91179	broad.mit.edu	37	22	20783888	20783888	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:20783888G>A	uc002zsj.1	-	8	1464	c.1359C>T	c.(1357-1359)CTC>CTT	p.L453L	SCARF2_uc002zsk.1_Silent_p.L453L	NM_153334	NP_699165	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2 isoform 1	453	Helical; (Potential).				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCAGGCAGACGAGCAGGACGA	0.677													9	47					0	0	0.010729	0	0
LZTR1	8216	broad.mit.edu	37	22	21340177	21340178	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:21340177_21340178CC>TT	uc002zto.2	+	3	414_415	c.311_312CC>TT	c.(310-312)TCC>TTT	p.S104F	LZTR1_uc002ztn.2_Missense_Mutation_p.S63F|LZTR1_uc011ahy.1_Intron|LZTR1_uc010gsr.1_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	104	Kelch 1.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			AAAGACTGCTCCTGGTGCAGGT	0.584													12	23					0	0	0.004672	0	0
LOC96610	96610	broad.mit.edu	37	22	22681955	22681955	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:22681955C>T	uc011aim.1	+	37		c.3446C>T								Parts of antibodies, mostly variable regions.												0						GGGAGCAGCTCCAACATTGGG	0.612													57	111					0	0	0.014410	0	0
LOC96610	96610	broad.mit.edu	37	22	23011004	23011004	+	RNA	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:23011004C>G	uc011aim.1	+	121		c.7690C>G								Parts of antibodies, mostly variable regions.												0						CTCCTATGAGCTGACACAGCC	0.562													9	115					0	0	0.013537	0	0
LOC96610	96610	broad.mit.edu	37	22	23090297	23090297	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:23090297G>A	uc011aim.1	+	203		c.10591G>A								Parts of antibodies, mostly variable regions.												0						ATCCCTGAGCGATTCTCTGGC	0.502													8	29					0	0	0.004482	0	0
BCR	613	broad.mit.edu	37	22	23523650	23523650	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:23523650C>T	uc002zww.2	+	1	1099	c.503C>T	c.(502-504)CCC>CTC	p.P168L	BCR_uc002zwx.2_Missense_Mutation_p.P168L	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	168	Kinase.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12						CATGGCCAGCCCGGGGCGGAC	0.697			T	ABL1| FGFR1|JAK2 	CML|ALL|AML								30	56					0	0	0.004289	0	0
GSTT2	2953	broad.mit.edu	37	22	24323179	24323179	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:24323179G>A	uc002zzb.3	+	2	228	c.153G>A	c.(151-153)CTG>CTA	p.L51L	DDT_uc002zza.3_5'Flank|GSTT2_uc002zzc.3_Silent_p.L51L	NM_000854	NP_000845	P0CG30	GSTT2_HUMAN	glutathione S-transferase theta 2	51	GST N-terminal.					cytoplasm	glutathione transferase activity				0						TCAACAGCCTGGGGAAACTGC	0.542													36	90					0	0	0.014410	0	0
CABIN1	23523	broad.mit.edu	37	22	24451467	24451468	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:24451467_24451468CC>TT	uc002zzi.1	+	9	1065_1066	c.938_939CC>TT	c.(937-939)TCC>TTT	p.S313F	CABIN1_uc002zzj.1_Missense_Mutation_p.S263F|CABIN1_uc002zzl.1_Missense_Mutation_p.S313F|CABIN1_uc010guk.1_Missense_Mutation_p.S268F|CABIN1_uc002zzk.1_Missense_Mutation_p.S268F	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	313					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CTTGAGTCCTCCATGGTGGTGA	0.574													8	60					0	0	0.004672	0	0
ADORA2A	135	broad.mit.edu	37	22	24836822	24836822	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:24836822C>T	uc002zzx.2	+	5	1367	c.604C>T	c.(604-606)CTG>TTG	p.L202L	ADORA2A_uc002zzy.3_Silent_p.L202L|ADORA2A_uc011ajs.1_Silent_p.L63L|ADORA2A_uc010gup.2_Silent_p.L202L|ADORA2A_uc010guq.2_Silent_p.L202L|ADORA2A_uc003aab.2_Silent_p.L202L|ADORA2A_uc003aac.2_Silent_p.L63L|C22orf45_uc003aad.1_Intron	NM_000675	NP_000666	P29274	AA2AR_HUMAN	adenosine A2a receptor	202	Cytoplasmic.				apoptosis|blood coagulation|cAMP biosynthetic process|cellular defense response|inflammatory response|nerve growth factor receptor signaling pathway|phagocytosis|sensory perception	integral to plasma membrane|membrane fraction	enzyme binding				0	Colorectal(2;0.196)				Caffeine(DB00201)|Defibrotide(DB04932)|Pegademase bovine(DB00061)|Theophylline(DB00277)	GCGGATCTTCCTGGCGGCGCG	0.592													14	164					0	0	0.004007	0	0
MYO18B	84700	broad.mit.edu	37	22	26423114	26423114	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:26423114G>A	uc003abz.1	+	43	7424	c.7174G>A	c.(7174-7176)GAC>AAC	p.D2392N	MYO18B_uc003aca.1_Missense_Mutation_p.D2273N|MYO18B_uc010guy.1_Missense_Mutation_p.D2274N|MYO18B_uc010guz.1_Missense_Mutation_p.D2272N|MYO18B_uc011aka.1_Missense_Mutation_p.D1546N|MYO18B_uc011akb.1_Missense_Mutation_p.D1905N|MYO18B_uc010gva.1_Missense_Mutation_p.D375N|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2392						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GTCCTCTGTGGACGATGCGGG	0.597													9	78					0	0	0.004482	0	0
SEZ6L	23544	broad.mit.edu	37	22	26706643	26706643	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:26706643G>A	uc003acb.2	+	7	1678	c.1522G>A	c.(1522-1524)GTT>ATT	p.V508I	SEZ6L_uc003acc.2_Missense_Mutation_p.V508I|SEZ6L_uc011akc.1_Missense_Mutation_p.V508I|SEZ6L_uc003acd.2_Missense_Mutation_p.V508I|SEZ6L_uc011akd.1_Missense_Mutation_p.V508I|SEZ6L_uc003ace.2_Missense_Mutation_p.V508I|SEZ6L_uc003acf.1_Missense_Mutation_p.V281I|SEZ6L_uc010gvc.1_Missense_Mutation_p.V281I	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	508	CUB 2.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CAGGATGACGGTTCACAGCGG	0.532													6	54					0	0	0.004482	0	0
TFIP11	24144	broad.mit.edu	37	22	26902376	26902376	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:26902376G>A	uc003acr.2	-	5	787	c.413C>T	c.(412-414)TCT>TTT	p.S138F	TFIP11_uc003acs.2_Missense_Mutation_p.S138F|TFIP11_uc003act.2_Missense_Mutation_p.S138F	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	138					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						GTCCATGAAAGATTTGGTTCC	0.443													14	59					0	0	0.003163	0	0
KREMEN1	83999	broad.mit.edu	37	22	29533538	29533538	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:29533538C>T	uc011akm.1	+	6	853	c.840C>T	c.(838-840)GTC>GTT	p.V280V	KREMEN1_uc003ael.2_Silent_p.V280V|KREMEN1_uc011akn.1_Silent_p.V163V	NM_032045	NP_114434	Q96MU8	KREM1_HUMAN	kringle-containing transmembrane protein 1	278	Extracellular (Potential).|CUB.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding			ovary(3)|lung(2)	5						CCCACCGTGTCCTAGCCCGCT	0.587													14	27					0	0	0.002450	0	0
EWSR1	2130	broad.mit.edu	37	22	29684598	29684598	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:29684598C>T	uc003aet.2	+	8	1125	c.797C>T	c.(796-798)TCA>TTA	p.S266L	EWSR1_uc003aes.3_Missense_Mutation_p.S266L|EWSR1_uc003aev.2_Missense_Mutation_p.S272L|EWSR1_uc003aew.2_Missense_Mutation_p.S210L|EWSR1_uc003aex.2_Missense_Mutation_p.S266L|EWSR1_uc003aey.2_Missense_Mutation_p.S61L|EWSR1_uc003aez.2_5'Flank	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	266	30.|31 X approximate tandem repeats.|EAD (Gln/Pro/Thr-rich).|IQ.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						TCCTCAGGTTCATTCCGACAG	0.507			T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								6	58					0	0	0.001984	0	0
RFPL1	5988	broad.mit.edu	37	22	29837868	29837868	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:29837868C>T	uc003afn.2	+	2	920	c.711C>T	c.(709-711)TTC>TTT	p.F237F	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	237	B30.2/SPRY.						zinc ion binding				0						CTTTCCTCTTCGTAGACCGCA	0.512													22	71					0	0	0.002780	0	0
RFPL1	5988	broad.mit.edu	37	22	29838060	29838060	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:29838060G>A	uc003afn.2	+	2	1112	c.903G>A	c.(901-903)GTG>GTA	p.V301V	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	301	B30.2/SPRY.						zinc ion binding				0						TCTGTCCTGTGATAAACCCGG	0.463													6	61					0	0	0.001984	0	0
SEC14L3	266629	broad.mit.edu	37	22	30866041	30866041	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:30866041C>T	uc003ahy.2	-	4	288	c.199G>A	c.(199-201)GAT>AAT	p.D67N	SEC14L3_uc003ahz.2_5'UTR|SEC14L3_uc003aia.2_Missense_Mutation_p.D8N|SEC14L3_uc003aib.2_Missense_Mutation_p.D8N	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	67						integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	TGGTCAATATCCATGGTCTTC	0.547													22	139					0	0	0.002780	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30950957	30950957	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:30950957C>T	uc003aig.1	-	4	1395	c.1255G>A	c.(1255-1257)GAT>AAT	p.D419N	GAL3ST1_uc003aih.1_Missense_Mutation_p.D419N|GAL3ST1_uc003aii.1_Missense_Mutation_p.D419N|GAL3ST1_uc010gvz.1_Missense_Mutation_p.D419N	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	419	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CGCAGGAAATCGCGAATGAAC	0.682													7	20					0	0	0.003080	0	0
OSBP2	23762	broad.mit.edu	37	22	31091213	31091213	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:31091213C>T	uc003aiy.1	+	1	421	c.317C>T	c.(316-318)CCG>CTG	p.P106L	OSBP2_uc011ala.1_Intron|OSBP2_uc010gwc.1_Intron|OSBP2_uc003aix.1_Missense_Mutation_p.P106L|OSBP2_uc011alb.1_Missense_Mutation_p.P106L|OSBP2_uc003aiz.1_Missense_Mutation_p.P106L	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	106					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						GGGTCGCGGCCGGGGTCAGAG	0.677													11	49					0	0	0.001855	0	0
SMTN	6525	broad.mit.edu	37	22	31493304	31493304	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:31493304C>T	uc003ajl.1	+	16	2357	c.2139C>T	c.(2137-2139)TCC>TCT	p.S713S	SMTN_uc003ajk.1_Silent_p.S713S|SMTN_uc003ajm.1_Silent_p.S713S|SMTN_uc011ale.1_Silent_p.S798S|SMTN_uc011alf.1_Silent_p.S769S|SMTN_uc003ajn.1_Silent_p.S736S|SMTN_uc011alg.1_Silent_p.S169S|SMTN_uc003ajo.1_Silent_p.S236S|SMTN_uc010gwe.1_Silent_p.S93S	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	713	Poly-Ser.				muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						CCTCTTCCTCCTCATCCAAGA	0.567													6	70					0	0	0.001168	0	0
PISD	23761	broad.mit.edu	37	22	32017036	32017037	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:32017036_32017037GG>AA	uc003alm.3	-	6	796_797	c.789_790CC>TT	c.(787-792)TACCAC>TATTAC	p.H264Y	PISD_uc003alk.2_Missense_Mutation_p.H230Y|PISD_uc003all.2_Missense_Mutation_p.H229Y|PISD_uc011alr.1_Missense_Mutation_p.H229Y|PISD_uc003aln.3_Missense_Mutation_p.H264Y	NM_014338	NP_055153	Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	264					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)	TGGAAGCAGTGGTAGTCCCCAG	0.639											OREG0003530	type=REGULATORY REGION|Gene=PISD|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	37					0	0	0.004672	0	0
DEPDC5	9681	broad.mit.edu	37	22	32218690	32218690	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:32218690C>T	uc003als.2	+	24	2160	c.2018C>T	c.(2017-2019)TCC>TTC	p.S673F	DEPDC5_uc011als.1_Intron|DEPDC5_uc011alu.1_Missense_Mutation_p.S673F|DEPDC5_uc011alv.1_Intron|DEPDC5_uc003alt.2_Missense_Mutation_p.S673F|DEPDC5_uc003alu.2_Missense_Mutation_p.S113F|DEPDC5_uc003alv.2_Intron|DEPDC5_uc011alw.1_5'UTR|DEPDC5_uc011alt.1_Intron	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	673					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						CACAGCAATTCCCGCCAGCCT	0.542													4	39					0	0	0.009096	0	0
C22orf42	150297	broad.mit.edu	37	22	32547006	32547006	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:32547006C>T	uc003amd.2	-	6	507	c.466G>A	c.(466-468)GAA>AAA	p.E156K		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	156										ovary(1)|skin(1)	2						TCAGATATTTCCTGCAGTAAG	0.294													4	57					0	0	0.009096	0	0
SYN3	8224	broad.mit.edu	37	22	32929853	32929853	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:32929853C>T	uc003amx.2	-	9	1180	c.1021G>A	c.(1021-1023)GAA>AAA	p.E341K	SYN3_uc003amy.2_Missense_Mutation_p.E341K|SYN3_uc003amz.2_Missense_Mutation_p.E340K	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	341	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						CCAAACATTTCCGAGCAGCTG	0.577													4	36					0	0	0.000602	0	0
RASD2	23551	broad.mit.edu	37	22	35947550	35947550	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:35947550G>A	uc003anx.2	+	3	477	c.272G>A	c.(271-273)GGG>GAG	p.G91E	RASD2_uc003any.2_Missense_Mutation_p.G91E	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	91					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						CTCCCTGCAGGGGATGTCTTC	0.587													8	107					0	0	0.004482	0	0
APOL6	80830	broad.mit.edu	37	22	36055545	36055545	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:36055545G>A	uc003aoe.2	+	3	1228	c.934G>A	c.(934-936)GAA>AAA	p.E312K	APOL6_uc003aod.2_RNA	NM_030641	NP_085144	Q9BWW8	APOL6_HUMAN	apolipoprotein L6	312					lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity				0						TGGGACCTGCGAAACCGAGGC	0.443													13	44					0	0	0.002450	0	0
MYH9	4627	broad.mit.edu	37	22	36710238	36710238	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:36710238G>A	uc003apg.2	-	13	1737	c.1506C>T	c.(1504-1506)ATC>ATT	p.I502I	MYH9_uc003aph.1_Silent_p.I366I	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	502	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GGCCAAAGTCGATGAAGTTCC	0.547			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				8	44					0	0	0.003080	0	0
C22orf33	339669	broad.mit.edu	37	22	37397951	37397951	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:37397951C>T	uc003aqf.2	-	3	562	c.416G>A	c.(415-417)GGC>GAC	p.G139D	C22orf33_uc003aqe.2_Missense_Mutation_p.G54D	NM_001163857	NP_001157329	O43247	EAN57_HUMAN	hypothetical protein LOC339669 isoform 1	139											0						AATGATGCTGCCCTTCTGGTT	0.627													3	17					0	0	0.009096	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37499389	37499389	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:37499389C>T	uc003aqs.1	-	2	210	c.96G>A	c.(94-96)GAG>GAA	p.E32E	TMPRSS6_uc003aqt.1_Silent_p.E23E|TMPRSS6_uc003aqu.2_Silent_p.E23E	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	32	Cytoplasmic (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						TCCCCTCCGGCTCCGCTTCCT	0.662													15	120					0	0	0.003163	0	0
TRIOBP	11078	broad.mit.edu	37	22	38119807	38119807	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:38119807C>T	uc003atr.2	+	7	1515	c.1244C>T	c.(1243-1245)TCC>TTC	p.S415F	TRIOBP_uc003atu.2_Missense_Mutation_p.S243F|TRIOBP_uc003atq.1_Missense_Mutation_p.S415F|TRIOBP_uc003ats.1_Missense_Mutation_p.S243F	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	415					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCCAAAGCCTCCAGAACCTCC	0.577													9	49					0	0	0.004482	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120449	38120449	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:38120449C>T	uc003atr.2	+	7	2157	c.1886C>T	c.(1885-1887)GCC>GTC	p.A629V	TRIOBP_uc003atu.2_Missense_Mutation_p.A457V|TRIOBP_uc003atq.1_Missense_Mutation_p.A629V|TRIOBP_uc003ats.1_Missense_Mutation_p.A457V	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	629					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					ACATCCTGTGCCCAGCGGGAC	0.597													11	52					0	0	0.013537	0	0
BAIAP2L2	80115	broad.mit.edu	37	22	38483257	38483257	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:38483257G>A	uc003auw.2	-	11	1277	c.1133C>T	c.(1132-1134)CCC>CTC	p.P378L	BAIAP2L2_uc003auv.2_5'Flank	NM_025045	NP_079321	Q6UXY1	BI2L2_HUMAN	BAI1-associated protein 2-like 2	378	SH3.				filopodium assembly|signal transduction		cytoskeletal adaptor activity|SH3 domain binding			pancreas(1)	1	Melanoma(58;0.045)					GTACGCCTCGGGGAACCAACC	0.413													8	33					0	0	0.008291	0	0
SYNGR1	9145	broad.mit.edu	37	22	39770347	39770347	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:39770347C>T	uc003axq.3	+	2	188	c.126C>T	c.(124-126)TCC>TCT	p.S42S	SYNGR1_uc003axo.3_Silent_p.S42S|SYNGR1_uc003axp.3_5'UTR|TAB1_uc003axr.2_5'UTR|SYNGR1_uc003axs.3_Silent_p.S43S	NM_004711	NP_004702	O43759	SNG1_HUMAN	synaptogyrin 1 isoform 1a	42	Helical; (Potential).|MARVEL.				regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity	cell junction|integral to plasma membrane|melanosome					0	Melanoma(58;0.04)					TGTTCGGCTCCATCGTGAACG	0.657													8	38					0	0	0.004482	0	0
ATF4	468	broad.mit.edu	37	22	39917503	39917503	+	Missense_Mutation	SNP	C	T	T	rs34854854		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:39917503C>T	uc003axz.2	+	2	333	c.53C>T	c.(52-54)TCC>TTC	p.S18F	ATF4_uc011aol.1_5'UTR|ATF4_uc003aya.2_Missense_Mutation_p.S18F	NM_182810	NP_877962	P18848	ATF4_HUMAN	activating transcription factor 4	18					cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Melanoma(58;0.04)					GACTTGATGTCCCCCTTCGAC	0.532													18	79					0	0	0.008871	0	0
MEI1	150365	broad.mit.edu	37	22	42120046	42120046	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:42120046G>A	uc003baz.1	+	7	858	c.833G>A	c.(832-834)GGA>GAA	p.G278E	WBP2NL_uc011ape.1_5'Flank|LOC339674_uc003bba.1_5'Flank|MEI1_uc003bay.3_Missense_Mutation_p.G278E|MEI1_uc011apd.1_RNA	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	278							binding			central_nervous_system(1)|skin(1)	2						GGGTCATCAGGAAATACCTCA	0.463													6	26					0	0	0.001168	0	0
SREBF2	6721	broad.mit.edu	37	22	42263110	42263110	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:42263110C>T	uc003bbi.2	+	2	533	c.364C>T	c.(364-366)CCC>TCC	p.P122S	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	122	Gly/Pro/Ser-rich.|Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						CACCTCAGTTCCCACCACACC	0.428													18	72					0	0	0.004990	0	0
WBP2NL	164684	broad.mit.edu	37	22	42422778	42422778	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:42422778T>C	uc011ape.1	+	7	539	c.523T>C	c.(523-525)TAT>CAT	p.Y175H	WBP2NL_uc003bbt.2_Missense_Mutation_p.Y175H|WBP2NL_uc011apk.1_Missense_Mutation_p.Y47H|WBP2NL_uc003bbu.2_RNA|WBP2NL_uc003bbv.1_RNA	NM_152613	NP_689826	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	175	10 X 7 AA tandem repeat of Y-G-X-P-P-X-G.|1.				egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			ovary(2)	2						AGTTATTGTCTATGGAGCCCC	0.463													4	120					0	0	0.000602	0	0
PACSIN2	11252	broad.mit.edu	37	22	43280453	43280453	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:43280453G>A	uc010gzg.2	-	6	946	c.724C>T	c.(724-726)CGC>TGC	p.R242C	PACSIN2_uc003bdg.3_Missense_Mutation_p.R242C|PACSIN2_uc003bde.3_Missense_Mutation_p.R242C|PACSIN2_uc003bdf.3_Missense_Mutation_p.R242C	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	242					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				CGGAAGAAGCGAAGGCGTTTC	0.527													30	56					0	0	0.012213	0	0
PNPLA5	150379	broad.mit.edu	37	22	44276713	44276713	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:44276713G>A	uc003beg.2	-	9	1349	c.1252C>T	c.(1252-1254)CCT>TCT	p.P418S	PNPLA5_uc011aqc.1_Missense_Mutation_p.P278S|PNPLA5_uc003beh.2_Missense_Mutation_p.P304S	NM_138814	NP_620169	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	418					lipid catabolic process		hydrolase activity				0		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				TCTCTATGAGGAGCTATCTGG	0.657													6	22					0	0	0.001168	0	0
PARVG	64098	broad.mit.edu	37	22	44585031	44585031	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:44585031C>T	uc011aqe.1	+	6	709	c.285C>T	c.(283-285)ATC>ATT	p.I95I	PARVG_uc003bep.2_Silent_p.I95I|PARVG_uc011aqf.1_Silent_p.I95I|PARVG_uc003beq.2_RNA|PARVG_uc003ber.2_RNA	NM_001137605	NP_001131077	Q9HBI0	PARVG_HUMAN	parvin, gamma	95	CH 1.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding				0		Ovarian(80;0.024)|all_neural(38;0.0299)				CAGAGGACATCGCCCTGACAG	0.652													9	61					0	0	0.006214	0	0
PRR5-ARHGAP8	553158	broad.mit.edu	37	22	45110520	45110520	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:45110520C>T	uc003bfd.2	+	2	456	c.184C>T	c.(184-186)CAG>TAG	p.Q62*	PRR5_uc003bew.1_Nonsense_Mutation_p.Q53*|PRR5_uc003bex.1_5'UTR|PRR5_uc010gzt.1_Nonsense_Mutation_p.Q85*|PRR5_uc010gzu.1_Intron|PRR5_uc003bey.1_Nonsense_Mutation_p.Q53*|PRR5_uc003bez.1_5'UTR|PRR5-ARHGAP8_uc003bfc.2_Nonsense_Mutation_p.Q62*|PRR5-ARHGAP8_uc011aqi.1_Nonsense_Mutation_p.Q53*|PRR5_uc003bfa.1_5'UTR|PRR5_uc003bfb.1_Nonsense_Mutation_p.Q62*|PRR5_uc003bfe.1_RNA	NM_181335	NP_851852			Rho GTPase activating protein 8 isoform 2											skin(2)	2						GCTGCCCGACCAGGAGCTCTT	0.647													6	77					0	0	0.001984	0	0
CELSR1	9620	broad.mit.edu	37	22	46765661	46765661	+	Silent	SNP	G	A	A	rs142317772		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:46765661G>A	uc003bhw.1	-	26	7800	c.7800C>T	c.(7798-7800)CCC>CCT	p.P2600P	CELSR1_uc011arc.1_Nonsense_Mutation_p.R1066*	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2600	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGCAGAAGTCGGGGTTCCCGT	0.647													5	56					0	0	0.000602	0	0
FAM116B	414918	broad.mit.edu	37	22	50750572	50750573	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:50750572_50750573GG>AA	uc011aru.1	-	21	1825_1826	c.1753_1754CC>TT	c.(1753-1755)CCC>TTC	p.P585F	FAM116B_uc011arv.1_Missense_Mutation_p.P585F	NM_001001794	NP_001001794	Q8NEG7	F116B_HUMAN	family with sequence similarity 116, member B	585											0		all_cancers(38;4.34e-09)|all_epithelial(38;3.03e-08)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TTTGTTCTAGGGAGGGCACAAG	0.653													6	38					0	0	0.004672	0	0
FAM116B	414918	broad.mit.edu	37	22	50754507	50754507	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:50754507G>A	uc011aru.1	-	9	721	c.649C>T	c.(649-651)CCA>TCA	p.P217S	FAM116B_uc011arv.1_Missense_Mutation_p.P217S	NM_001001794	NP_001001794	Q8NEG7	F116B_HUMAN	family with sequence similarity 116, member B	217											0		all_cancers(38;4.34e-09)|all_epithelial(38;3.03e-08)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ACCCTGGATGGGATGCGCACC	0.632													15	82					0	0	0.004007	0	0
CPT1B	1375	broad.mit.edu	37	22	51011344	51011344	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:51011344G>A	uc003bmk.3	-	10	1474	c.1312C>T	c.(1312-1314)CTC>TTC	p.L438F	CPT1B_uc003bml.2_Missense_Mutation_p.L438F|CPT1B_uc003bmm.2_Missense_Mutation_p.L438F|CPT1B_uc003bmo.2_Missense_Mutation_p.L438F|CPT1B_uc011asa.1_Missense_Mutation_p.L404F|CPT1B_uc003bmn.2_Missense_Mutation_p.L438F|CPT1B_uc011asb.1_Missense_Mutation_p.L357F|CHKB-CPT1B_uc003bmp.2_Missense_Mutation_p.L235F	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	438	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		TTGCCATAGAGGCTGAGGCTG	0.507													5	159					0	0	0.001168	0	0
SHANK3	85358	broad.mit.edu	37	22	51160692	51160692	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr22:51160692C>T	uc003bne.1	+	22	4479	c.4479C>T	c.(4477-4479)CCC>CCT	p.P1493P	SHANK3_uc003bnf.1_Silent_p.P940P|SHANK3_uc010hbg.1_Silent_p.P675P	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1493										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		GGGGGGACCCCGTGGAGAGCC	0.682													7	31					0	0	0.003080	0	0
CNTN6	27255	broad.mit.edu	37	3	1394070	1394070	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:1394070C>T	uc003boz.2	+	12	1694	c.1427C>T	c.(1426-1428)TCA>TTA	p.S476L	CNTN6_uc011asj.1_Missense_Mutation_p.S404L|CNTN6_uc003bpa.2_Missense_Mutation_p.S476L	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	476	Ig-like C2-type 5.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GATGCTGGATCATATACATGC	0.358													9	27					0	0	0.006214	0	0
IL5RA	3568	broad.mit.edu	37	3	3139668	3139668	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:3139668G>A	uc011ask.1	-	8	1239	c.595C>T	c.(595-597)CCC>TCC	p.P199S	IL5RA_uc010hbq.2_Missense_Mutation_p.P199S|IL5RA_uc010hbr.2_Intron|IL5RA_uc010hbs.2_Missense_Mutation_p.P199S|IL5RA_uc011asl.1_Missense_Mutation_p.P199S|IL5RA_uc011asm.1_Missense_Mutation_p.P199S|IL5RA_uc010hbt.2_Missense_Mutation_p.P199S|IL5RA_uc011asn.1_Missense_Mutation_p.P199S|IL5RA_uc010hbu.2_Missense_Mutation_p.P199S	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	199	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		AAAGTCCTGGGAAACCAGCAT	0.478													4	43					0	0	0.009096	0	0
LRRN1	57633	broad.mit.edu	37	3	3887163	3887163	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:3887163G>A	uc003bpt.3	+	2	1599	c.838G>A	c.(838-840)GAA>AAA	p.E280K	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	280	LRR 9.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CAAAATCCAAGAAGGGGACTT	0.408													12	66					0	0	0.001855	0	0
GRM7	2917	broad.mit.edu	37	3	7620850	7620850	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:7620850G>A	uc003bqm.2	+	8	2531	c.2257G>A	c.(2257-2259)GAT>AAT	p.D753N	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.D753N|GRM7_uc003bql.2_Missense_Mutation_p.D753N|GRM7_uc003bqn.1_Missense_Mutation_p.D336N|GRM7_uc010hch.1_Missense_Mutation_p.D264N	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	753	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TGACATTACAGATCTCCAAAT	0.438													5	67					0	0	0.000602	0	0
SRGAP3	9901	broad.mit.edu	37	3	9027564	9027564	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:9027564C>T	uc003brf.1	-	22	3615	c.2939G>A	c.(2938-2940)AGG>AAG	p.R980K	SRGAP3_uc003brg.1_Missense_Mutation_p.R956K	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	980	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CGTGTTCTGCCTCTCGAGTTC	0.647			T	RAF1	pilocytic astrocytoma								4	31					0	0	0.000602	0	0
RPUSD3	285367	broad.mit.edu	37	3	9879874	9879874	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:9879874G>A	uc011atk.1	-	9	886	c.882C>T	c.(880-882)CTC>CTT	p.L294L	ARPC4_uc003btc.1_Intron|RPUSD3_uc011atl.1_Silent_p.L279L	NM_173659	NP_775930	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	294					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(1)	1	Medulloblastoma(99;0.227)					GGCGTCTGAGGAGGGCTTCAT	0.622													8	72					0	0	0.006214	0	0
FANCD2	2177	broad.mit.edu	37	3	10106108	10106108	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:10106108G>A	uc003buw.2	+	22	2094	c.2016G>A	c.(2014-2016)CCG>CCA	p.P672P	FANCD2_uc003bux.1_Silent_p.P672P|FANCD2_uc003buy.1_Silent_p.P672P|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	672					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GTGTTGTTCCGGAAGGGTAGG	0.458			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				8	166					0	0	0.001855	0	0
VHL	7428	broad.mit.edu	37	3	10188288	10188288	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:10188288G>A	uc003bvc.2	+	2	644	c.431G>A	c.(430-432)GGA>GAA	p.G144E	VHL_uc003bvd.2_Intron	NM_000551	NP_000542	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor isoform 1	144	Involved in binding to CCT complex.				anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.G144fs*14(5)|p.G144fs*15(4)|p.G144*(3)|p.G144A(1)|p.G144fs*19(1)		kidney(1273)|soft_tissue(24)|adrenal_gland(15)|large_intestine(13)|pancreas(5)|endometrium(4)|thyroid(3)|upper_aerodigestive_tract(3)|central_nervous_system(2)|lung(2)|pleura(1)|paratesticular_tissues(1)	1346				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		AATGTTGACGGACAGCCTATT	0.423		1	D|Mis|N|F|S		renal|hemangioma|pheochromocytoma	renal|hemangioma|pheochromocytoma			von_Hippel-Lindau_disease|Chuvash_Polycythemia_|Pheochromocytoma_(Adrenal)_Familial				11	107					0	0	0.010729	0	0
ATP2B2	491	broad.mit.edu	37	3	10391825	10391825	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:10391825G>A	uc003bvt.2	-	16	2814	c.2375C>T	c.(2374-2376)TCC>TTC	p.S792F	ATP2B2_uc003bvv.2_Missense_Mutation_p.S747F|ATP2B2_uc003bvw.2_Missense_Mutation_p.S747F|ATP2B2_uc010hdo.2_Missense_Mutation_p.S497F	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	792	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GTCCGTTGGGGAGGAGCGAGC	0.637													4	33					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	3	12299655	12299655	+	RNA	SNP	G	A	A	rs112489134	by1000genomes	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:12299655G>A	uc003bwp.1	-	1		c.298C>T				NR_003112				NR_003112																		CTGGTTCTCCGAAATGTCCAC	0.517													10	28					0	0	0.008291	0	0
NUP210	23225	broad.mit.edu	37	3	13364826	13364826	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:13364826C>T	uc003bxv.1	-	34	4834	c.4751G>A	c.(4750-4752)AGA>AAA	p.R1584K		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1584	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GTTAGAGCTTCTGTCTCCCAC	0.572													11	124					0	0	0.010729	0	0
WNT7A	7476	broad.mit.edu	37	3	13860784	13860784	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:13860784A>G	uc003bye.1	-	4	1012	c.707T>C	c.(706-708)GTT>GCT	p.V236A		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	236					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						CTCCACGTGAACGGCCTCGTT	0.617													6	50					0	0	0.001168	0	0
SLC6A6	6533	broad.mit.edu	37	3	14485316	14485316	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:14485316C>T	uc010heg.2	+	10	465	c.174C>T	c.(172-174)TTC>TTT	p.F58F	SLC6A6_uc010hee.1_Silent_p.F58F|SLC6A6_uc003byp.2_Silent_p.F58F|SLC6A6_uc010hef.1_RNA|SLC6A6_uc003byq.2_Silent_p.F58F|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	58	Helical; Name=1; (Potential).				cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						CTGGCGGCTTCGTGGGCTTGG	0.627													10	60					0	0	0.013537	0	0
C3orf20	84077	broad.mit.edu	37	3	14724407	14724407	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:14724407C>T	uc003byy.2	+	3	591	c.187C>T	c.(187-189)CCG>TCG	p.P63S	C3orf20_uc003byz.2_Intron|C3orf20_uc003bza.2_Intron|C3orf20_uc003byx.1_Missense_Mutation_p.P63S	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	63						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						AGTGCCTACCCCGTCCGACAT	0.517													16	78					0	0	0.006122	0	0
GALNTL2	117248	broad.mit.edu	37	3	16268889	16268889	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:16268889G>A	uc003car.3	+	10	2277	c.1802G>A	c.(1801-1803)GGG>GAG	p.G601E	GALNTL2_uc003caq.3_Missense_Mutation_p.G334E|GALNTL2_uc003cas.3_Missense_Mutation_p.G131E	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	601	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						ATTCTTTCTGGGAAATGCATG	0.403													6	70					0	0	0.001984	0	0
PLCL2	23228	broad.mit.edu	37	3	17052006	17052006	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:17052006C>T	uc011awc.1	+	5	1249	c.1144C>T	c.(1144-1146)CCA>TCA	p.P382S	PLCL2_uc010het.1_Intron|PLCL2_uc011awd.1_Missense_Mutation_p.P264S	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	390					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						CAAATATGAACCATCCAAAGA	0.398													8	42					0	0	0.004482	0	0
TBC1D5	9779	broad.mit.edu	37	3	17425431	17425431	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:17425431C>T	uc003cbf.2	-	9	2251	c.586G>A	c.(586-588)GAA>AAA	p.E196K	TBC1D5_uc010hev.2_Missense_Mutation_p.E196K|TBC1D5_uc003cbe.2_Missense_Mutation_p.E196K|TBC1D5_uc010hew.1_Missense_Mutation_p.E148K	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	196	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						TGCTCGTTTTCTCTGGCATAA	0.333													11	53					0	0	0.010729	0	0
EOMES	8320	broad.mit.edu	37	3	27761750	27761750	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:27761750G>A	uc003cdx.2	-	2	948	c.948C>T	c.(946-948)TTC>TTT	p.F316F	EOMES_uc003cdy.3_Silent_p.F316F|EOMES_uc010hfn.2_Silent_p.F316F|EOMES_uc011axc.1_Silent_p.F21F	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	316	T-box.				CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						CCACCTCTACGAACACATTGT	0.512													16	84					0	0	0.004007	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713418	30713419	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:30713418_30713419CC>TT	uc003ceo.2	+	4	1125_1126	c.743_744CC>TT	c.(742-744)ACC>ATT	p.T248I	TGFBR2_uc003cen.2_Missense_Mutation_p.T273I	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	248	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						GAGCTGGACACCCTGGTGGGGA	0.525													5	34					0	0	0.004672	0	0
TRANK1	9881	broad.mit.edu	37	3	36872577	36872578	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:36872577_36872578CC>TT	uc003cgj.2	-	12	7016_7017	c.6714_6715GG>AA	c.(6712-6717)GTGGCC>GTAACC	p.A2239T		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2789					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TTCTGGTAGGCCACTTGCTGCC	0.525													14	103					0	0	0.004672	0	0
TRANK1	9881	broad.mit.edu	37	3	36876394	36876394	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:36876394C>G	uc003cgj.2	-	11	4042	c.3740G>C	c.(3739-3741)AGA>ACA	p.R1247T		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1797	TPR 4.				DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GGCAGCATCTCTTATCTAGGA	0.348													4	16					0	0	0.009096	0	0
TRANK1	9881	broad.mit.edu	37	3	36896923	36896923	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:36896923G>A	uc003cgj.2	-	3	2810	c.2508C>T	c.(2506-2508)TCC>TCT	p.S836S		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1386					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GCTCGTGGATGGACCATGGGA	0.498													14	95					0	0	0.003163	0	0
TRANK1	9881	broad.mit.edu	37	3	36898681	36898681	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:36898681C>T	uc003cgj.2	-	3	1052	c.750G>A	c.(748-750)AAG>AAA	p.K250K		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	800					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TAGACAGCTTCTTCAGCATTT	0.507													12	176					0	0	0.003163	0	0
TRANK1	9881	broad.mit.edu	37	3	36898710	36898710	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:36898710C>T	uc003cgj.2	-	3	1023	c.721G>A	c.(721-723)GAG>AAG	p.E241K		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	791					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CACTCGATCTCCCAGGTCATG	0.493													26	160					0	0	0.009535	0	0
VILL	50853	broad.mit.edu	37	3	38044690	38044690	+	Missense_Mutation	SNP	G	A	A	rs144181954		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:38044690G>A	uc003chj.2	+	15	1977	c.1691G>A	c.(1690-1692)CGG>CAG	p.R564Q	VILL_uc003chl.2_Missense_Mutation_p.R564Q	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	564					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		GAGATGGCACGGGTGGTGGTC	0.632													4	39					0	0	0.009096	0	0
DLEC1	9940	broad.mit.edu	37	3	38139081	38139081	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:38139081G>A	uc003cho.1	+	17	2539	c.2518G>A	c.(2518-2520)GAA>AAA	p.E840K	DLEC1_uc003chp.1_Missense_Mutation_p.E840K|DLEC1_uc010hgv.1_Missense_Mutation_p.E840K|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	840					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GTGTGAAATCGAAGACTCGCC	0.587													5	36					0	0	0.001168	0	0
SCN5A	6331	broad.mit.edu	37	3	38622611	38622611	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:38622611G>A	uc003cio.2	-	17	3233	c.3039C>T	c.(3037-3039)CCC>CCT	p.P1013P	SCN5A_uc003cin.2_Silent_p.P1013P|SCN5A_uc003cil.3_Silent_p.P1013P|SCN5A_uc010hhi.2_Silent_p.P1013P|SCN5A_uc010hhk.2_Silent_p.P1013P|SCN5A_uc011ayr.1_Silent_p.P1013P|SCN5A_uc010hhj.1_Silent_p.P624P	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1013					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CCGTCTCTGGGGGTGGCGGGG	0.692													5	17					0	0	0.000602	0	0
SCN10A	6336	broad.mit.edu	37	3	38753813	38753813	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:38753813A>C	uc003ciq.2	-	22	3928	c.3928T>G	c.(3928-3930)TGC>GGC	p.C1310G		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1310	III.|Helical; Name=S5 of repeat III; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TAGTTGATGCACCTCCAAAAC	0.478													6	63					0	0	0.001984	0	0
SCN10A	6336	broad.mit.edu	37	3	38768112	38768112	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:38768112C>T	uc003ciq.2	-	16	3072	c.3072G>A	c.(3070-3072)GTG>GTA	p.V1024V		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1024					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CTTTGGGGATCACTTCCTGCT	0.542													4	30					0	0	0.000602	0	0
SCN10A	6336	broad.mit.edu	37	3	38812823	38812823	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:38812823G>A	uc003ciq.2	-	4	546	c.546C>T	c.(544-546)TTC>TTT	p.F182F		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	182	I.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCAGGTACGTGAACTCATTTA	0.443													16	62					0	0	0.003163	0	0
SCN11A	11280	broad.mit.edu	37	3	38888526	38888526	+	Missense_Mutation	SNP	G	A	A	rs143537709		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:38888526G>A	uc011ays.1	-	26	5234	c.5035C>T	c.(5035-5037)CGC>TGC	p.R1679C		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1679					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R1679C(1)		skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CAGTGGAGGCGATCTTCACTC	0.463													5	52					0	0	0.000602	0	0
TTC21A	199223	broad.mit.edu	37	3	39174603	39174603	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:39174603C>T	uc003cjc.2	+	20	2821	c.2644C>T	c.(2644-2646)CCC>TCC	p.P882S	TTC21A_uc003cje.2_Missense_Mutation_p.P883S|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.P834S|TTC21A_uc011ayy.1_Missense_Mutation_p.P3S|TTC21A_uc003cjf.2_Missense_Mutation_p.P3S	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	882							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		AGAAATGATTCCCTCCCAGAA	0.502													8	43					0	0	0.003080	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307287	39307287	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:39307287G>A	uc003cjl.2	-	2	806	c.714C>T	c.(712-714)ATC>ATT	p.I238I		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	238	Helical; Name=6; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		GGAAAAACACGATGACCACCA	0.428													21	59					0	0	0.008871	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307958	39307958	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:39307958C>T	uc003cjl.2	-	2	135	c.43G>A	c.(43-45)GAT>AAT	p.D15N		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	15	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		GCCAAATCATCGTACTCAAAG	0.448													11	20					0	0	0.010729	0	0
CCDC13	152206	broad.mit.edu	37	3	42784515	42784515	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:42784515C>T	uc003cly.3	-	8	944	c.860G>A	c.(859-861)CGG>CAG	p.R287Q		NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	287	Potential.									ovary(1)	1						AGACTGGCTCCGGGCCTGGCC	0.547													38	110					0	0	0.009718	0	0
CCBP2	1238	broad.mit.edu	37	3	42906138	42906138	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:42906138C>T	uc003cme.2	+	3	323	c.144C>T	c.(142-144)TTC>TTT	p.F48F	CCBP2_uc003cmd.1_Silent_p.F48F|CCBP2_uc003cmf.2_Silent_p.F48F|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	48	Extracellular (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		GCAAAGTCTTCCTCCCAGTCT	0.512													14	102					0	0	0.003163	0	0
CCBP2	1238	broad.mit.edu	37	3	42906201	42906201	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:42906201G>A	uc003cme.2	+	3	386	c.207G>A	c.(205-207)ATG>ATA	p.M69I	CCBP2_uc003cmd.1_Missense_Mutation_p.M69I|CCBP2_uc003cmf.2_Missense_Mutation_p.M69I|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	69	Helical; Name=1; (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		TTCTTCTCATGGTCTTGCTCC	0.532													8	99					0	0	0.003080	0	0
ZNF197	10168	broad.mit.edu	37	3	44684905	44684905	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:44684905C>T	uc003cnm.2	+	6	2489	c.2283C>T	c.(2281-2283)CCC>CCT	p.P761P	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	761					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		GAGAAAAACCCTTTGAATGCA	0.433													12	63					0	0	0.010729	0	0
ZNF501	115560	broad.mit.edu	37	3	44776524	44776524	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:44776524C>T	uc003cnu.1	+	3	1012	c.611C>T	c.(610-612)TCC>TTC	p.S204F	ZNF501_uc003cnv.1_Missense_Mutation_p.P148S	NM_145044	NP_659481	Q96CX3	ZN501_HUMAN	zinc finger protein 501	204	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		CAGAACTCTTCCCTTGTTGAA	0.418													4	26					0	0	0.009096	0	0
FYCO1	79443	broad.mit.edu	37	3	46009314	46009314	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:46009314C>T	uc003cpb.3	-	8	1718	c.1512G>A	c.(1510-1512)CTG>CTA	p.L504L	FYCO1_uc011bal.1_Silent_p.L504L	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	504	Potential.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CCTCCTGCTCCAGCAGCTCCT	0.607													9	78					0	0	0.010729	0	0
CCR5	1234	broad.mit.edu	37	3	46414630	46414630	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:46414630C>T	uc003cpo.3	+	3	359	c.237C>T	c.(235-237)TTC>TTT	p.F79F	CCR5_uc010hjd.2_Silent_p.F79F	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	79	Helical; Name=2; (Potential).				cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	ACCTGTTTTTCCTTCTTACTG	0.483													8	109					0	0	0.006214	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713399	46713399	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:46713399G>A	uc003cqa.1	-	24	2849	c.2659C>T	c.(2659-2661)CTC>TTC	p.L887F	ALS2CL_uc003cpx.1_Missense_Mutation_p.L234F|ALS2CL_uc003cpy.1_RNA|ALS2CL_uc003cpz.1_Missense_Mutation_p.L402F|ALS2CL_uc003cqb.1_Missense_Mutation_p.L887F|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	887	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		ACGTAGATGAGAAGTGGCAGC	0.632													4	26					0	0	0.009096	0	0
CELSR3	1951	broad.mit.edu	37	3	48685349	48685349	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:48685349G>A	uc003cul.2	-	20	7335	c.7054C>T	c.(7054-7056)CGA>TGA	p.R2352*	CELSR3_uc003cuf.1_Nonsense_Mutation_p.R2422*|CELSR3_uc010hkg.2_Nonsense_Mutation_p.R335*	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2352	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCCTGGCCTCGAAAGAGGTTG	0.632													14	113					0	0	0.004007	0	0
LAMB2	3913	broad.mit.edu	37	3	49159721	49159721	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:49159721G>A	uc003cwe.2	-	28	4955	c.4656C>T	c.(4654-4656)ATC>ATT	p.I1552I	USP19_uc003cvz.3_5'Flank|USP19_uc011bcg.1_5'Flank|USP19_uc003cwb.2_5'Flank|USP19_uc003cwd.1_5'Flank|USP19_uc011bch.1_5'Flank|USP19_uc011bci.1_5'Flank	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1552	Domain I.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCAGGTGCTGGATCTGCTCAG	0.597													4	53					0	0	0.009096	0	0
LAMB2	3913	broad.mit.edu	37	3	49161226	49161226	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:49161226G>A	uc003cwe.2	-	24	4031	c.3732C>T	c.(3730-3732)ATC>ATT	p.I1244I		NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1244	Domain II.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGGCACCTACGATGCCCTGCA	0.617													6	34					0	0	0.001168	0	0
C3orf62	375341	broad.mit.edu	37	3	49308822	49308822	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:49308822C>T	uc003cwn.2	-	3	798	c.595G>A	c.(595-597)GAA>AAA	p.E199K	C3orf62_uc003cwm.2_Missense_Mutation_p.E48K|hsa-mir-4271|MI0015879_5'Flank	NM_198562	NP_940964	Q6ZUJ4	CC062_HUMAN	hypothetical protein LOC375341	199											0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGGTTCAATTCGTTTTCAAAT	0.428													8	51					0	0	0.003080	0	0
GPX1	2876	broad.mit.edu	37	3	49395482	49395482	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:49395482G>C	uc011bcl.1	-	2	310	c.230C>G	c.(229-231)CCG>CGG	p.P77R	GPX1_uc011bcm.1_Missense_Mutation_p.P77R	NM_000581	NP_000572	P07203	GPX1_HUMAN	glutathione peroxidase 1 isoform 1	77					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CTGGTTGCACGGGAAGCCGAG	0.617													3	27					0	0	0.004672	0	0
BSN	8927	broad.mit.edu	37	3	49688110	49688110	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:49688110G>A	uc003cxe.3	+	4	1698	c.1584G>A	c.(1582-1584)CCG>CCA	p.P528P		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	528					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TAGGAGAGCCGACCCCCCTGC	0.612													13	110					0	0	0.001855	0	0
BSN	8927	broad.mit.edu	37	3	49692777	49692777	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:49692777G>A	uc003cxe.3	+	5	5902	c.5788G>A	c.(5788-5790)GAT>AAT	p.D1930N		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1930					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GAGCATGGCAGATGCTGCCCC	0.662													5	42					0	0	0.000602	0	0
MST1R	4486	broad.mit.edu	37	3	49939880	49939880	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:49939880G>A	uc003cxy.3	-	1	1427	c.1163C>T	c.(1162-1164)TCC>TTC	p.S388F	MST1R_uc011bdd.1_Missense_Mutation_p.S388F|MST1R_uc011bde.1_Missense_Mutation_p.S388F|MST1R_uc011bdf.1_Missense_Mutation_p.S388F|MST1R_uc011bdg.1_Missense_Mutation_p.S388F	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	388	Extracellular (Potential).|Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		ATGGACTGGGGATTCACAACA	0.592													14	78					0	0	0.001855	0	0
RBM6	10180	broad.mit.edu	37	3	50102554	50102554	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:50102554C>T	uc003cyc.2	+	16	2810	c.2677C>T	c.(2677-2679)CCT>TCT	p.P893S	RBM6_uc010hlc.1_Missense_Mutation_p.P412S|RBM6_uc003cyd.2_Missense_Mutation_p.P371S|RBM6_uc003cye.2_Missense_Mutation_p.P371S|RBM6_uc011bdi.1_Missense_Mutation_p.P235S|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	893	Poly-Pro.				RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		AGAGAGTCCCCCTCCAGTAAG	0.542													7	44					0	0	0.001984	0	0
DOCK3	1795	broad.mit.edu	37	3	51274929	51274929	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:51274929C>T	uc011bds.1	+	21	2033	c.2010C>T	c.(2008-2010)ATC>ATT	p.I670I		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	670						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AGGTGTTCATCATCAACCTGC	0.473													5	21					0	0	0.001168	0	0
DOCK3	1795	broad.mit.edu	37	3	51308341	51308341	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:51308341G>A	uc011bds.1	+	24	2474	c.2451G>A	c.(2449-2451)GGG>GGA	p.G817G		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	817						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GGACACTGGGGAGCATGCCCA	0.527													13	55					0	0	0.013537	0	0
RRP9	9136	broad.mit.edu	37	3	51967753	51967753	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:51967753G>A	uc003dbw.1	-	14	1344	c.1305C>T	c.(1303-1305)TTC>TTT	p.F435F		NM_004704	NP_004695	O43818	U3IP2_HUMAN	RNA, U3 small nucleolar interacting protein 2	435	WD 7.				rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		CAGCCACCAGGAAGTCCCCAG	0.587													24	100					0	0	0.005443	0	0
RRP9	9136	broad.mit.edu	37	3	51968490	51968490	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:51968490G>A	uc003dbw.1	-	13	1297	c.1258C>T	c.(1258-1260)CTG>TTG	p.L420L		NM_004704	NP_004695	O43818	U3IP2_HUMAN	RNA, U3 small nucleolar interacting protein 2	420	WD 7.				rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		TCACTCACCAGGGGGATGTCA	0.582													3	14					0	0	0.000602	0	0
DUSP7	1849	broad.mit.edu	37	3	52088040	52088040	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:52088040C>T	uc003dct.2	-	2	947	c.868G>A	c.(868-870)GAG>AAG	p.E290K	DUSP7_uc010hma.2_Missense_Mutation_p.E290K	NM_001947	NP_001938	Q16829	DUS7_HUMAN	dual specificity phosphatase 7	290					inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TAGGTGAACTCGCCGCCGTGC	0.562													7	65					0	0	0.003080	0	0
TLR9	54106	broad.mit.edu	37	3	52257214	52257214	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:52257214C>T	uc003dda.1	-	2	1752	c.1118G>A	c.(1117-1119)GGC>GAC	p.G373D	TLR9_uc003ddb.2_Missense_Mutation_p.G470D	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	373	LRR 12.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	GAAGAAGATGCCGTGCATGTC	0.597													10	61					0	0	0.008291	0	0
NEK4	6787	broad.mit.edu	37	3	52794827	52794827	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:52794827G>A	uc003dfq.3	-	6	1136	c.947C>T	c.(946-948)TCC>TTC	p.S316F	NEK4_uc011bej.1_Missense_Mutation_p.S227F|NEK4_uc003dfr.2_Missense_Mutation_p.S316F	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	316					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		ATATGTCTGGGAGCCCTCAGA	0.398													5	57					0	0	0.001984	0	0
ITIH1	3697	broad.mit.edu	37	3	52813605	52813605	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:52813605T>A	uc003dfs.2	+	5	592	c.568T>A	c.(568-570)TTT>ATT	p.F190I	ITIH1_uc010hmn.1_RNA	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	190					hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GGTGCATCATTTTGAGGTAGA	0.532													5	60					0	0	0.001168	0	0
CACNA1D	776	broad.mit.edu	37	3	53736765	53736765	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:53736765G>A	uc003dgv.3	+	9	1481	c.1318G>A	c.(1318-1320)GAT>AAT	p.D440N	CACNA1D_uc003dgu.3_Missense_Mutation_p.D440N|CACNA1D_uc003dgy.3_Missense_Mutation_p.D440N|CACNA1D_uc003dgw.3_Missense_Mutation_p.D87N	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	440	Cytoplasmic (Potential).|Binding to the beta subunit (By similarity).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGGCTACTTGGATTGGATCAC	0.517													4	21					0	0	0.009096	0	0
CACNA1D	776	broad.mit.edu	37	3	53757872	53757872	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:53757872C>T	uc003dgv.3	+	14	2109	c.1946C>T	c.(1945-1947)TCC>TTC	p.S649F	CACNA1D_uc003dgu.3_Missense_Mutation_p.S669F|CACNA1D_uc003dgy.3_Missense_Mutation_p.S649F|CACNA1D_uc003dgw.3_Missense_Mutation_p.S316F	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	649	Cytoplasmic (Potential).|II.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TCCATGAAGTCCATCGCTTCG	0.448													6	82					0	0	0.001168	0	0
LRTM1	57408	broad.mit.edu	37	3	54959050	54959050	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:54959050G>A	uc003dhl.2	-	2	334	c.200C>T	c.(199-201)GCT>GTT	p.A67V	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	67	LRR 1.|Extracellular (Potential).					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		AAATGCAAAAGCAGGAAGATG	0.488													4	26					0	0	0.009096	0	0
ERC2	26059	broad.mit.edu	37	3	55733446	55733446	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:55733446C>T	uc003dhr.1	-	16	3063	c.2807G>A	c.(2806-2808)GGG>GAG	p.G936E	ERC2_uc003dhq.1_RNA	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	936						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TTGCGACCTCCCAGGAGATCg	0.373													13	184					0	0	0.001855	0	0
ERC2	26059	broad.mit.edu	37	3	56330403	56330403	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:56330403G>A	uc003dhr.1	-	3	974	c.718C>T	c.(718-720)CAC>TAC	p.H240Y		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	240	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TGGAGGAGGTGGTTGAGGTCT	0.562													9	52					0	0	0.006214	0	0
KCTD6	200845	broad.mit.edu	37	3	58486841	58486841	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:58486841C>T	uc003dkj.3	+	3	313	c.196C>T	c.(196-198)CGA>TGA	p.R66*	KCTD6_uc003dki.3_Nonsense_Mutation_p.R66*|KCTD6_uc003dkk.3_Nonsense_Mutation_p.R66*	NM_001128214	NP_001121686	Q8NC69	KCTD6_HUMAN	potassium channel tetramerisation domain	66	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)		ACCTCTTTTCCGATATGTCCT	0.433													7	42					0	0	0.003080	0	0
ACOX2	8309	broad.mit.edu	37	3	58508322	58508322	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:58508322T>C	uc003dkl.2	-	12	1708	c.1533A>G	c.(1531-1533)ATA>ATG	p.I511M		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	acyl-Coenzyme A oxidase 2	511					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		CTGAGTCCTTTATGAGCCTGA	0.493													3	48					0	0	0.009096	0	0
C3orf67	200844	broad.mit.edu	37	3	58792139	58792139	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:58792139G>A	uc003dkt.1	-	14	1875	c.1466C>T	c.(1465-1467)CCT>CTT	p.P489L	C3orf67_uc003dkr.1_RNA|C3orf67_uc003dks.1_Missense_Mutation_p.P430L	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	494											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		AGAAGGAGAAGGTGGGTTCAT	0.343													3	35					0	0	0.009096	0	0
CADPS	8618	broad.mit.edu	37	3	62518605	62518605	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:62518605G>A	uc003dll.2	-	13	2592	c.2232C>T	c.(2230-2232)ATC>ATT	p.I744I	CADPS_uc003dlk.1_Silent_p.I248I|CADPS_uc003dlm.2_Silent_p.I744I|CADPS_uc003dln.2_Silent_p.I727I	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	744					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GGGTGGGGTCGATCATGGCGC	0.517													6	49					0	0	0.001168	0	0
CADPS	8618	broad.mit.edu	37	3	62636752	62636752	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:62636752G>A	uc003dll.2	-	5	1333	c.973C>T	c.(973-975)CGC>TGC	p.R325C	CADPS_uc003dlm.2_Missense_Mutation_p.R325C|CADPS_uc003dln.2_Missense_Mutation_p.R325C	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	325					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GGAAATTTGCGTTCCTTGGGA	0.413													9	54					0	0	0.004482	0	0
THOC7	80145	broad.mit.edu	37	3	63823658	63823658	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:63823658G>A	uc003dlt.3	-	4	477	c.346C>T	c.(346-348)CGC>TGC	p.R116C	C3orf49_uc003dls.3_Intron|THOC7_uc003dlu.3_Missense_Mutation_p.R53C	NM_025075	NP_079351	Q6I9Y2	THOC7_HUMAN	Ngg1 interacting factor 3 like 1 binding protein	116	Potential.|Interaction with THOC5.|Interaction with NIF3L1.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	cytoplasm|THO complex part of transcription export complex	protein binding|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.000439)|Kidney(15;0.00194)|KIRC - Kidney renal clear cell carcinoma(15;0.00218)		TTACCTTGGCGATTTTTTCGT	0.348													11	53					0	0	0.010729	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64601692	64601692	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:64601692C>T	uc003dmg.2	-	20	3000	c.2968G>A	c.(2968-2970)GAA>AAA	p.E990K	ADAMTS9_uc011bfo.1_Missense_Mutation_p.E962K|ADAMTS9_uc003dmh.1_Missense_Mutation_p.E819K|ADAMTS9_uc003dmk.1_Missense_Mutation_p.E990K|ADAMTS9_uc011bfp.1_5'UTR	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	990	TSP type-1 3.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GAGCATTTTTCACGGTTGCTT	0.488													33	381					0	0	0.003755	0	0
MAGI1	9223	broad.mit.edu	37	3	65361455	65361455	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:65361455C>T	uc003dmn.2	-	18	3687	c.3161G>A	c.(3160-3162)GGA>GAA	p.G1054E	MAGI1_uc003dmm.2_Missense_Mutation_p.G1082E|MAGI1_uc003dmo.2_Missense_Mutation_p.G1083E|MAGI1_uc003dmp.2_Intron	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1083					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		AACTGTGTTTCCCGCTTCCTT	0.343													10	91					0	0	0.001855	0	0
GBE1	2632	broad.mit.edu	37	3	81635304	81635304	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:81635304G>A	uc003dqg.2	-	11	1557	c.1274C>T	c.(1273-1275)TCC>TTC	p.S425F	GBE1_uc011bgm.1_Missense_Mutation_p.S384F	NM_000158	NP_000149	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	425					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(3)	3		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		CCCTCCCTGGGAAATTGGAGA	0.403									Glycogen_Storage_Disease_type_IV				14	52					0	0	0.003163	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806032	97806032	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:97806032G>A	uc011bgs.1	+	1	16	c.16G>A	c.(16-18)GGA>AGA	p.G6R		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TATATCAGAGGGAAATAAGAC	0.368													8	63					0	0	0.004482	0	0
OR5H14	403273	broad.mit.edu	37	3	97868560	97868560	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:97868560G>A	uc003dsg.1	+	1	331	c.331G>A	c.(331-333)GAA>AAA	p.E111K		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGTAACCACGGAATGTTTTCT	0.413													14	132					0	0	0.004007	0	0
OR5K2	402135	broad.mit.edu	37	3	98216810	98216810	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:98216810G>A	uc011bgx.1	+	1	286	c.286G>A	c.(286-288)GAA>AAA	p.E96K		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TTCCCTCTATGAATGTGCAGT	0.463													8	92					0	0	0.004482	0	0
FAM55C	91775	broad.mit.edu	37	3	101535694	101535694	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:101535694T>A	uc003dvn.2	+	7	1615	c.978T>A	c.(976-978)TAT>TAA	p.Y326*	FAM55C_uc010hpn.2_Nonsense_Mutation_p.Y326*	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	326						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						CTGGGTATTATTATAAAGACC	0.353													4	43					0	0	0.009096	0	0
ZBED2	79413	broad.mit.edu	37	3	111312451	111312451	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:111312451C>T	uc003dxy.2	-	2	1483	c.598G>A	c.(598-600)GAG>AAG	p.E200K	CD96_uc003dxv.2_Intron|CD96_uc003dxw.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_024508	NP_078784	Q9BTP6	ZBED2_HUMAN	zinc finger, BED domain containing 2	200							DNA binding|metal ion binding			skin(1)	1						TGGCATGCCTCCTTCTCAGCC	0.522													4	35					0	0	0.009096	0	0
ZBED2	79413	broad.mit.edu	37	3	111312974	111312974	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:111312974C>T	uc003dxy.2	-	2	960	c.75G>A	c.(73-75)GAG>GAA	p.E25E	CD96_uc003dxv.2_Intron|CD96_uc003dxw.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_024508	NP_078784	Q9BTP6	ZBED2_HUMAN	zinc finger, BED domain containing 2	25							DNA binding|metal ion binding			skin(1)	1						TAATCTCTTCCTCCTCCTTCA	0.517													6	44					0	0	0.001168	0	0
SLC9A10	285335	broad.mit.edu	37	3	111988903	111988903	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:111988903A>T	uc003dyu.2	-	7	857	c.635T>A	c.(634-636)ATT>AAT	p.I212N	SLC9A10_uc011bhu.1_Intron|SLC9A10_uc010hqc.2_Missense_Mutation_p.I212N	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	212	Helical; (Potential).				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						ATATGAACAAATTCCACCCAC	0.308													4	80					0	0	0.000602	0	0
CCDC80	151887	broad.mit.edu	37	3	112358494	112358494	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:112358494G>A	uc003dzf.2	-	2	477	c.259C>T	c.(259-261)CGC>TGC	p.R87C	CCDC80_uc011bhv.1_Missense_Mutation_p.R87C|CCDC80_uc003dzg.2_Missense_Mutation_p.R87C|CCDC80_uc003dzh.1_Missense_Mutation_p.R87C	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	87										ovary(2)	2						TCTGTTGGGCGAGCTAGTCTC	0.607													7	64					0	0	0.001984	0	0
ZBTB20	26137	broad.mit.edu	37	3	114069913	114069913	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:114069913C>T	uc003ebi.2	-	4	1192	c.1012G>A	c.(1012-1014)GAC>AAC	p.D338N	ZBTB20_uc003ebj.2_Missense_Mutation_p.D265N|ZBTB20_uc010hqp.2_Missense_Mutation_p.D265N|ZBTB20_uc003ebk.2_Missense_Mutation_p.D265N|ZBTB20_uc003ebl.2_Missense_Mutation_p.D265N|ZBTB20_uc003ebm.2_Missense_Mutation_p.D265N|ZBTB20_uc003ebn.2_Missense_Mutation_p.D265N|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CCGTAGTAGTCGTAATCGTCC	0.617													16	91					0	0	0.004990	0	0
STXBP5L	9515	broad.mit.edu	37	3	120673799	120673799	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:120673799G>A	uc003eec.3	+	3	342	c.202G>A	c.(202-204)GGT>AGT	p.G68S	STXBP5L_uc011bji.1_Missense_Mutation_p.G68S	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	68					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AGTTCGGCATGGTTTTCCTCA	0.279													6	45					0	0	0.003080	0	0
STXBP5L	9515	broad.mit.edu	37	3	121001148	121001148	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:121001148C>T	uc003eec.3	+	20	2286	c.2146C>T	c.(2146-2148)CCT>TCT	p.P716S	STXBP5L_uc011bji.1_Intron	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	716					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		TAACTTTTATCCTGATTTAAC	0.388													6	42					0	0	0.003080	0	0
ARGFX	503582	broad.mit.edu	37	3	121303897	121303897	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:121303897G>A	uc003eef.2	+	4	449	c.354G>A	c.(352-354)CCG>CCA	p.P118P		NM_001012659	NP_001012677	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	118	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(114;0.152)		TCGACCTACCGGAGTCAACAG	0.512													8	52					0	0	0.003080	0	0
ILDR1	286676	broad.mit.edu	37	3	121712387	121712387	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:121712387G>A	uc003ees.2	-	7	1315	c.1209C>T	c.(1207-1209)CAC>CAT	p.H403H	ILDR1_uc003eeq.2_Silent_p.H371H|ILDR1_uc003eer.2_Silent_p.H359H|ILDR1_uc010hrg.2_Silent_p.H314H	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	403	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		TAGAGCTACGGTGCCTTCCAC	0.597													5	28					0	0	0.000602	0	0
ILDR1	286676	broad.mit.edu	37	3	121712643	121712643	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:121712643G>A	uc003ees.2	-	7	1059	c.953C>T	c.(952-954)TCC>TTC	p.S318F	ILDR1_uc003eeq.2_Missense_Mutation_p.S286F|ILDR1_uc003eer.2_Missense_Mutation_p.S274F|ILDR1_uc010hrg.2_Missense_Mutation_p.S229F	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	318	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		GCCCAGGGAGGACAGCATGCT	0.587													8	34					0	0	0.003080	0	0
CD86	942	broad.mit.edu	37	3	121825277	121825277	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:121825277G>A	uc003eet.2	+	4	749	c.633G>A	c.(631-633)ACG>ACA	p.T211T	CD86_uc011bjo.1_Silent_p.T129T|CD86_uc011bjp.1_Silent_p.T99T|CD86_uc003eeu.2_Silent_p.T205T	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	211	Ig-like C2-type.|Extracellular (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	CTGATGTTACGAGCAATATGA	0.393													12	106					0	0	0.001855	0	0
CASR	846	broad.mit.edu	37	3	121980930	121980930	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:121980930G>A	uc003eev.3	+	4	1420	c.1048G>A	c.(1048-1050)GAG>AAG	p.E350K	CASR_uc003eew.3_Missense_Mutation_p.E350K	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	350	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TTTTGCCAAGGAGTTTTGGGA	0.507													6	33					0	0	0.001984	0	0
CASR	846	broad.mit.edu	37	3	122002643	122002643	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:122002643C>T	uc003eev.3	+	7	2214	c.1842C>T	c.(1840-1842)ATC>ATT	p.I614I	CASR_uc003eew.3_Silent_p.I624I	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	614	Helical; Name=1; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCTTTGGGATCGCACTCACCC	0.537													8	49					0	0	0.006214	0	0
ADCY5	111	broad.mit.edu	37	3	123044289	123044289	+	Silent	SNP	G	A	A	rs138891983		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:123044289G>A	uc003egh.1	-	8	1968	c.1968C>T	c.(1966-1968)ATC>ATT	p.I656I	ADCY5_uc003egg.1_Silent_p.I289I|ADCY5_uc003egi.1_Silent_p.I215I	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	656	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TCATCTTGGCGATCATGGCCT	0.587													12	102					0	0	0.003163	0	0
KALRN	8997	broad.mit.edu	37	3	124390733	124390733	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:124390733C>T	uc003ehg.2	+	48	7054	c.6927C>T	c.(6925-6927)TTC>TTT	p.F2309F	KALRN_uc003ehi.2_Silent_p.F650F|KALRN_uc003ehk.2_Silent_p.F612F|KALRN_uc011bjz.1_Silent_p.F401F	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2308					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GGGACAAGTTCGAAGCCAGCA	0.473													8	89					0	0	0.006214	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125824611	125824611	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:125824611G>A	uc003eim.1	-	22	2801	c.2611C>T	c.(2611-2613)CCC>TCC	p.P871S	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.P770S|ALDH1L1_uc003ein.1_Missense_Mutation_p.P406S	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	871	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CCTCCGAAGGGAGCGGCCACG	0.453													12	96					0	0	0.003163	0	0
PLXNA1	5361	broad.mit.edu	37	3	126708364	126708364	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:126708364C>T	uc003ejg.2	+	1	863	c.859C>T	c.(859-861)CGC>TGC	p.R287C		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	310	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		TGTGGAGTACCGCCTGGTGCA	0.637													14	133					0	0	0.004007	0	0
GATA2	2624	broad.mit.edu	37	3	128204917	128204917	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:128204917G>A	uc003ekm.3	-	4	959	c.524C>T	c.(523-525)CCC>CTC	p.P175L	GATA2_uc003ekn.3_Missense_Mutation_p.P175L|GATA2_uc003eko.2_Missense_Mutation_p.P175L	NM_001145661	NP_001139133	P23769	GATA2_HUMAN	GATA binding protein 2 isoform 1	175					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(13)|lung(1)|skin(1)	15				GBM - Glioblastoma multiforme(114;0.173)		GGGTGGCGTGGGTGGGAAGCC	0.682			Mis		AML(CML blast transformation)								4	29					0	0	0.009096	0	0
KIAA1257	57501	broad.mit.edu	37	3	128696930	128696930	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:128696930C>T	uc003elj.3	-	5	962	c.766G>A	c.(766-768)GGA>AGA	p.G256R	KIAA1257_uc003elg.1_Missense_Mutation_p.G256R|KIAA1257_uc003eli.3_Missense_Mutation_p.G144R	NM_020741	NP_065792	Q9ULG3	K1257_HUMAN	hypothetical protein LOC57501	256											0						TCTTGTTTTCCTGGCGGATGT	0.448													5	50					0	0	0.000602	0	0
COPG	22820	broad.mit.edu	37	3	128979213	128979213	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:128979213C>T	uc003els.2	+	11	1009	c.909C>T	c.(907-909)CTC>CTT	p.L303L	COPG_uc010htb.2_Silent_p.L209L	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	303	HEAT 2.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						AGGCTGCTCTCCGCTATGCTG	0.567													5	77					0	0	0.003080	0	0
IFT122	55764	broad.mit.edu	37	3	129183591	129183591	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:129183591C>T	uc003emm.2	+	7	736	c.530C>T	c.(529-531)TCG>TTG	p.S177L	IFT122_uc003eml.2_Missense_Mutation_p.S228L|IFT122_uc003emn.2_Missense_Mutation_p.S177L|IFT122_uc003emo.2_Missense_Mutation_p.S125L|IFT122_uc003emp.2_Missense_Mutation_p.S27L|IFT122_uc010htc.2_Missense_Mutation_p.S228L|IFT122_uc011bky.1_Missense_Mutation_p.S27L|IFT122_uc003emq.2_Intron|IFT122_uc003emr.2_Missense_Mutation_p.S27L|IFT122_uc011bla.1_Missense_Mutation_p.S27L|IFT122_uc011bkx.1_Intron|IFT122_uc011bkz.1_RNA	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	177					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						GGCTCCCTCTCGCCAATATGG	0.502													10	80					0	0	0.008291	0	0
RHO	6010	broad.mit.edu	37	3	129247885	129247885	+	Silent	SNP	C	T	T	rs149615742	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:129247885C>T	uc003emt.2	+	1	404	c.309C>T	c.(307-309)TTC>TTT	p.F103F		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	103	Extracellular.				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	ATGGATACTTCGTCTTCGGGC	0.602													10	78					0	0	0.010729	0	0
COL6A6	131873	broad.mit.edu	37	3	130311933	130311933	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:130311933G>A	uc010htl.2	+	15	4431	c.4400G>A	c.(4399-4401)GGA>GAA	p.G1467E	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1467	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GGAATTGACGGATTAAACGGA	0.378													23	191					0	0	0.006320	0	0
PIK3R4	30849	broad.mit.edu	37	3	130449249	130449249	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:130449249G>A	uc003enj.2	-	5	2069	c.1488C>T	c.(1486-1488)TTC>TTT	p.F496F		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	496					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						CTAATTCCAGGAATCTCAGAG	0.303													8	40					0	0	0.006214	0	0
TMEM108	66000	broad.mit.edu	37	3	133098932	133098932	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:133098932C>T	uc003eph.2	+	4	651	c.377C>T	c.(376-378)TCC>TTC	p.S126F	TMEM108_uc003epi.2_Missense_Mutation_p.S126F|TMEM108_uc003epj.1_Missense_Mutation_p.S126F|TMEM108_uc003epk.2_Intron|TMEM108_uc003epm.2_Missense_Mutation_p.S77F	NM_023943	NP_076432	Q6UXF1	TM108_HUMAN	transmembrane protein 108 precursor	126	Pro-rich.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)	4						GCAACCACATCCTCCAAGCCA	0.692													5	29					0	0	0.001984	0	0
EPHB1	2047	broad.mit.edu	37	3	134670780	134670780	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:134670780G>A	uc003eqt.2	+	3	911	c.691G>A	c.(691-693)GAA>AAA	p.E231K	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Intron	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	231	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CAACGCAGAGGAAGTGGACGT	0.542													12	122					0	0	0.013537	0	0
EPHB1	2047	broad.mit.edu	37	3	134960079	134960079	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:134960079C>T	uc003eqt.2	+	13	2656	c.2436C>T	c.(2434-2436)ATC>ATT	p.I812I	EPHB1_uc003equ.2_Silent_p.I373I	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	812	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GCTATGGGATCGTCATGTGGG	0.527													13	139					0	0	0.003163	0	0
ARMC8	25852	broad.mit.edu	37	3	137963936	137963936	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:137963936C>T	uc003esa.1	+	13	1370	c.1003C>T	c.(1003-1005)CAT>TAT	p.H335Y	ARMC8_uc003erw.2_Missense_Mutation_p.H335Y|ARMC8_uc003erx.2_Missense_Mutation_p.H335Y|ARMC8_uc003ery.2_Missense_Mutation_p.H307Y|ARMC8_uc003erz.2_Missense_Mutation_p.H307Y|ARMC8_uc011bmf.1_Missense_Mutation_p.H318Y|ARMC8_uc011bmg.1_Missense_Mutation_p.H282Y|ARMC8_uc011bmh.1_Missense_Mutation_p.H276Y|ARMC8_uc003esb.1_Missense_Mutation_p.H307Y|ARMC8_uc003esc.1_Missense_Mutation_p.H107Y	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	349	ARM 7.						binding				0						ATAGCTTGATCATGATTTAAA	0.388													25	119					0	0	0.004656	0	0
CEP70	80321	broad.mit.edu	37	3	138219580	138219580	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:138219580T>C	uc003esl.2	-	14	1563	c.1365A>G	c.(1363-1365)GAA>GAG	p.E455E	CEP70_uc011bmk.1_Silent_p.E435E|CEP70_uc011bml.1_Silent_p.E437E|CEP70_uc011bmm.1_Silent_p.E303E|CEP70_uc003esm.2_Silent_p.E455E	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	455					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						GTATTACCTTTTCCTTATTTT	0.313													17	188					0	0	0.006122	0	0
C3orf72	401089	broad.mit.edu	37	3	138668410	138668410	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:138668410G>A	uc003esx.1	+	2	280	c.149G>A	c.(148-150)GGA>GAA	p.G50E	FOXL2_uc003esw.2_5'Flank|C3orf72_uc011bmr.1_5'UTR	NM_001040061	NP_001035150	Q6ZUU3	CC072_HUMAN	chromosome 3 open reading frame 72	50											0						TGCACCCTGGGAAGGGCTGGA	0.542													9	20					0	0	0.004482	0	0
ATR	545	broad.mit.edu	37	3	142188360	142188360	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:142188360T>C	uc003eux.3	-	38	6493	c.6371A>G	c.(6370-6372)AAG>AGG	p.K2124R	ATR_uc003euy.1_Missense_Mutation_p.K10R	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2124	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TGTGATAACCTTGTTTATTTT	0.343								Other_conserved_DNA_damage_response_genes					8	48					0	0	0.006214	0	0
SLC9A9	285195	broad.mit.edu	37	3	143550880	143550880	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:143550880C>T	uc003evn.2	-	2	541	c.359G>A	c.(358-360)GGA>GAA	p.G120E	SLC9A9_uc011bnk.1_Intron	NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	120					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						TATAGCATTTCCTTGATGAGG	0.294													6	39					0	0	0.001168	0	0
PLOD2	5352	broad.mit.edu	37	3	145803060	145803060	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:145803060C>T	uc003evs.1	-	11	1634	c.1128G>A	c.(1126-1128)ATG>ATA	p.M376I	PLOD2_uc003evq.1_Silent_p.R36R|PLOD2_uc011bnm.1_Missense_Mutation_p.M321I|PLOD2_uc003evr.1_Missense_Mutation_p.M376I	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	376					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	GGCAAAAGTCCCTAACAGTGA	0.289													5	25					0	0	0.000602	0	0
WWTR1	25937	broad.mit.edu	37	3	149290687	149290687	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:149290687G>A	uc003exe.2	-	2	548	c.532C>T	c.(532-534)CCT>TCT	p.P178S	WWTR1_uc003exf.2_Missense_Mutation_p.P178S|WWTR1_uc011bns.1_Missense_Mutation_p.P178S|WWTR1_uc003exh.2_Missense_Mutation_p.P178S	NM_015472	NP_056287	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	178					hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GACCTCTGAGGCACTGGTGTG	0.388													9	55					0	0	0.008291	0	0
CLRN1	7401	broad.mit.edu	37	3	150690300	150690300	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:150690300A>T	uc003eyk.1	-	1	487	c.196T>A	c.(196-198)TTC>ATC	p.F66I	CLRN1OS_uc011bny.1_Intron|CLRN1OS_uc003eyl.2_5'Flank	NM_174878	NP_777367	P58418	CLRN1_HUMAN	clarin 1 isoform a	66					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			TCTCCGTGGAAAAGCCCGTAC	0.507													6	70					0	0	0.001168	0	0
IGSF10	285313	broad.mit.edu	37	3	151161445	151161445	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:151161445C>T	uc011bod.1	-	5	5290	c.5290G>A	c.(5290-5292)GAA>AAA	p.E1764K	IGSF10_uc011bob.1_5'Flank|IGSF10_uc011boc.1_5'Flank	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1764	Ig-like C2-type 4.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CACTTCAGTTCCACAGTGCTT	0.507													5	48					0	0	0.001168	0	0
AADACL2	344752	broad.mit.edu	37	3	151475347	151475347	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:151475347G>A	uc003ezc.2	+	5	1291	c.1171G>A	c.(1171-1173)GAT>AAT	p.D391N	AADACL2_uc010hvn.2_Missense_Mutation_p.D178N	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	391						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TAGGATAAGAGATATGTATGT	0.333													6	60					0	0	0.001984	0	0
MME	4311	broad.mit.edu	37	3	154802065	154802065	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:154802065C>T	uc010hvr.1	+	2	320	c.109C>T	c.(109-111)CTC>TTC	p.L37F	MME_uc003fab.1_Missense_Mutation_p.L37F|MME_uc003fac.1_Missense_Mutation_p.L37F|MME_uc003fad.1_Missense_Mutation_p.L37F|MME_uc003fae.1_Missense_Mutation_p.L37F	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	37	Helical; Signal-anchor for type II membrane protein; (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CCTTGTCCTGCTCCTCACCAT	0.468													7	84					0	0	0.003080	0	0
MME	4311	broad.mit.edu	37	3	154834733	154834733	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:154834733T>C	uc010hvr.1	+	7	823	c.612T>C	c.(610-612)TTT>TTC	p.F204F	MME_uc003fab.1_Silent_p.F204F|MME_uc003fac.1_Silent_p.F204F|MME_uc003fad.1_Silent_p.F204F|MME_uc003fae.1_Silent_p.F204F	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	204	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TTAATTTGTTTGTTGGCACTG	0.289													7	30					0	0	0.001984	0	0
CCNL1	57018	broad.mit.edu	37	3	156866200	156866200	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:156866200G>A	uc003fbf.2	-	11	2010	c.1411C>T	c.(1411-1413)CGT>TGT	p.R471C	CCNL1_uc003fbd.1_Intron|CCNL1_uc003fbe.2_Missense_Mutation_p.R265C|CCNL1_uc003fbg.2_RNA|CCNL1_uc011bor.1_RNA	NM_020307	NP_064703	Q9UK58	CCNL1_HUMAN	cyclin L1	471					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			lung(3)|breast(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			GATCGAGAACGAGATTTTTTC	0.448													8	98					0	0	0.003080	0	0
SI	6476	broad.mit.edu	37	3	164755722	164755723	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:164755722_164755723GG>AA	uc003fei.2	-	21	2453_2454	c.2391_2392CC>TT	c.(2389-2394)ATCCCC>ATTTCC	p.P798S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	798	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCTTGAATGGGGATGATATAAC	0.327										HNSCC(35;0.089)			4	23					0	0	0.004672	0	0
SI	6476	broad.mit.edu	37	3	164767590	164767590	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:164767590G>A	uc003fei.2	-	14	1648	c.1586C>T	c.(1585-1587)CCG>CTG	p.P529L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	529	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AGGAGTAAACGGTGGATAATT	0.279										HNSCC(35;0.089)			9	45					0	0	0.006214	0	0
SI	6476	broad.mit.edu	37	3	164792437	164792437	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:164792437G>A	uc003fei.2	-	3	199	c.137C>T	c.(136-138)TCA>TTA	p.S46L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	46	Ser/Thr-rich.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AGCTGGAGTTGAAGTAGAATC	0.318										HNSCC(35;0.089)			5	67					0	0	0.001168	0	0
ZBBX	79740	broad.mit.edu	37	3	167045777	167045777	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:167045777C>T	uc003fep.2	-	11	1138	c.815G>A	c.(814-816)GGA>GAA	p.G272E	ZBBX_uc011bpc.1_Missense_Mutation_p.G272E|ZBBX_uc003feq.2_Missense_Mutation_p.G243E	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	272						intracellular	zinc ion binding			ovary(2)	2						ATCATGATTTCCGGTTCTCCA	0.318													12	65					0	0	0.002450	0	0
MECOM	2122	broad.mit.edu	37	3	168833626	168833626	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:168833626C>T	uc003ffi.3	-	7	1739	c.1470G>A	c.(1468-1470)CTG>CTA	p.L490L	MECOM_uc010hwk.1_Silent_p.L513L|MECOM_uc003ffj.3_Silent_p.L555L|MECOM_uc011bpi.1_Silent_p.L491L|MECOM_uc003ffn.3_Silent_p.L490L|MECOM_uc003ffk.2_Silent_p.L490L|MECOM_uc003ffl.2_Silent_p.L650L|MECOM_uc011bpj.1_Silent_p.L678L|MECOM_uc011bpk.1_Silent_p.L480L|MECOM_uc010hwn.2_Silent_p.L678L	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	490					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GCAGCCCCACCAGTCCTGTTG	0.438													9	81					0	0	0.004482	0	0
MECOM	2122	broad.mit.edu	37	3	168834404	168834404	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:168834404G>A	uc003ffi.3	-	7	961	c.692C>T	c.(691-693)TCC>TTC	p.S231F	MECOM_uc010hwk.1_Missense_Mutation_p.S254F|MECOM_uc003ffj.3_Missense_Mutation_p.S296F|MECOM_uc011bpi.1_Missense_Mutation_p.S232F|MECOM_uc003ffn.3_Missense_Mutation_p.S231F|MECOM_uc003ffk.2_Missense_Mutation_p.S231F|MECOM_uc003ffl.2_Missense_Mutation_p.S391F|MECOM_uc011bpj.1_Missense_Mutation_p.S419F|MECOM_uc011bpk.1_Missense_Mutation_p.S221F|MECOM_uc010hwn.2_Missense_Mutation_p.S419F	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	231	Interaction with MAPK9, SMAD3 and probably SUV39H1.|C2H2-type 7.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TTTATTTAAGGAAGACGTAGT	0.453													9	65					0	0	0.010729	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540285	169540285	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:169540285C>T	uc003fgb.2	+	1	576	c.576C>T	c.(574-576)ATC>ATT	p.I192I		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	192	LRR 8.										0						CCCTGGAAATCATTGACCTGG	0.493													8	51					0	0	0.003080	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540380	169540380	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:169540380C>T	uc003fgb.2	+	1	671	c.671C>T	c.(670-672)CCC>CTC	p.P224L		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	224	LRR 9.										0						AACAACCTTCCCGTTCTGCCC	0.542													17	46					0	0	0.004990	0	0
SAMD7	344658	broad.mit.edu	37	3	169644351	169644351	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:169644351G>A	uc003fgd.2	+	6	568	c.301G>A	c.(301-303)GAA>AAA	p.E101K	SAMD7_uc003fge.2_Missense_Mutation_p.E101K|SAMD7_uc011bpo.1_Missense_Mutation_p.E2K	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	101										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GACAGAAATGGAAATGTATGC	0.388													5	26					0	0	0.000602	0	0
TNIK	23043	broad.mit.edu	37	3	170912416	170912416	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:170912416C>T	uc003fhh.2	-	5	660	c.315G>A	c.(313-315)ATG>ATA	p.M105I	TNIK_uc003fhi.2_Missense_Mutation_p.M105I|TNIK_uc003fhj.2_Missense_Mutation_p.M105I|TNIK_uc003fhk.2_Missense_Mutation_p.M105I|TNIK_uc003fhl.2_Missense_Mutation_p.M105I|TNIK_uc003fhm.2_Missense_Mutation_p.M105I|TNIK_uc003fhn.2_Missense_Mutation_p.M105I|TNIK_uc003fho.2_Missense_Mutation_p.M105I	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	105	Protein kinase.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CACAAAACTCCATCACCAACT	0.438													9	81					0	0	0.006214	0	0
TNIK	23043	broad.mit.edu	37	3	170945975	170945975	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:170945975G>A	uc003fhh.2	-	3	504	c.159C>T	c.(157-159)ATC>ATT	p.I53I	TNIK_uc003fhi.2_Silent_p.I53I|TNIK_uc003fhj.2_Silent_p.I53I|TNIK_uc003fhk.2_Silent_p.I53I|TNIK_uc003fhl.2_Silent_p.I53I|TNIK_uc003fhm.2_Silent_p.I53I|TNIK_uc003fhn.2_Silent_p.I53I|TNIK_uc003fho.2_Silent_p.I53I	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	53	Protein kinase.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CCATAACCTTGATGGCTGCAA	0.308													11	63					0	0	0.003163	0	0
ACTL6A	86	broad.mit.edu	37	3	179287619	179287619	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:179287619T>C	uc003fjw.2	+	2	206	c.33T>C	c.(31-33)GTT>GTC	p.V11V	ACTL6A_uc003fjx.2_5'UTR|ACTL6A_uc003fjy.2_5'UTR	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	11					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			CAGATGAAGTTGGAGCCCTTG	0.299													14	48					0	0	0.002450	0	0
LAMP3	27074	broad.mit.edu	37	3	182871915	182871915	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:182871915A>C	uc003flh.3	-	2	538	c.314T>G	c.(313-315)GTC>GGC	p.V105G		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	105	Lumenal (Potential).|Thr-rich.				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			CTGGGTTGTGACCAGGGTGTA	0.507													4	52					0	0	0.009096	0	0
MCF2L2	23101	broad.mit.edu	37	3	183014923	183014923	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:183014923G>A	uc003fli.1	-	12	1428	c.1338C>T	c.(1336-1338)CTC>CTT	p.L446L	MCF2L2_uc003flj.1_Silent_p.L446L|MCF2L2_uc011bqr.1_Intron|uc003fln.1_RNA|uc003flo.2_5'Flank	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	446					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GGGAAGCCAAGAGGTAGATTC	0.532													5	51					0	0	0.001984	0	0
MCF2L2	23101	broad.mit.edu	37	3	183041031	183041031	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:183041031G>A	uc003fli.1	-	6	685	c.595C>T	c.(595-597)CAC>TAC	p.H199Y	MCF2L2_uc003flj.1_Missense_Mutation_p.H199Y|MCF2L2_uc003flp.1_Missense_Mutation_p.H234Y	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	199					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ACAGTGCGGTGATTTACCCAC	0.512													11	58					0	0	0.002450	0	0
ABCC5	10057	broad.mit.edu	37	3	183689601	183689601	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:183689601G>A	uc003fmg.2	-	11	1676	c.1511C>T	c.(1510-1512)TCC>TTC	p.S504F	ABCC5_uc011bqt.1_Missense_Mutation_p.S32F|ABCC5_uc010hxl.2_Missense_Mutation_p.S504F	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	504						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CTGGATACTGGAGTGGGAGGA	0.493													8	32					0	0	0.006214	0	0
HTR3E	285242	broad.mit.edu	37	3	183823957	183823957	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:183823957C>T	uc010hxq.2	+	8	1433	c.967C>T	c.(967-969)CTG>TTG	p.L323L	HTR3E_uc003fml.3_Silent_p.L308L|HTR3E_uc003fmm.2_Silent_p.L338L|HTR3E_uc010hxr.2_Silent_p.L349L|HTR3E_uc003fmn.2_Silent_p.L323L	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	323	Helical; Name=3; (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GGTGGGCAGCCTGCTGGAGAC	0.637													6	47					0	0	0.001984	0	0
PSMD2	5708	broad.mit.edu	37	3	184026546	184026546	+	Silent	SNP	C	T	T	rs11545171		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:184026546C>T	uc003fnn.1	+	21	2628	c.2595C>T	c.(2593-2595)TTC>TTT	p.F865F	PSMD2_uc011brj.1_Silent_p.F706F|PSMD2_uc011brk.1_Silent_p.F735F	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	865					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	TCACAGGGTTCCAGACGCATA	0.517											OREG0015948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	83					0	0	0.006214	0	0
FETUB	26998	broad.mit.edu	37	3	186370352	186370352	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:186370352G>A	uc010hyq.2	+	8	1342	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K	FETUB_uc011brz.1_Missense_Mutation_p.E213K|FETUB_uc003fqn.2_Missense_Mutation_p.E361K|FETUB_uc003fqo.2_Missense_Mutation_p.E256K|FETUB_uc010hyr.2_Missense_Mutation_p.E324K|FETUB_uc010hys.2_Missense_Mutation_p.E213K|FETUB_uc003fqp.3_Missense_Mutation_p.E296K	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	361						extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		TTTCCCCAAAGAAAAAGCACG	0.552													4	56					0	0	0.009096	0	0
RFC4	5984	broad.mit.edu	37	3	186509532	186509532	+	Silent	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:186509532C>G	uc003fqz.2	-	8	1006	c.783G>C	c.(781-783)GTG>GTC	p.V261V	RFC4_uc011bsc.1_Silent_p.V261V|RFC4_uc011bsd.1_Silent_p.V261V	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	261					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TGTCTGTAATCACTTTCTCTG	0.333													14	47					0	0	0.001855	0	0
TP63	8626	broad.mit.edu	37	3	189587118	189587118	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:189587118C>T	uc003fry.2	+	9	1224	c.1135C>T	c.(1135-1137)CGT>TGT	p.R379C	TP63_uc003frx.2_Missense_Mutation_p.R379C|TP63_uc003frz.2_Missense_Mutation_p.R379C|TP63_uc010hzc.1_Missense_Mutation_p.R379C|TP63_uc003fsa.2_Missense_Mutation_p.R285C|TP63_uc003fsb.2_Missense_Mutation_p.R285C|TP63_uc003fsc.2_Missense_Mutation_p.R285C|TP63_uc003fsd.2_Missense_Mutation_p.R285C|TP63_uc010hzd.1_Missense_Mutation_p.R200C|TP63_uc003fse.1_Missense_Mutation_p.R256C	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	379	Interaction with HIPK2.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACCAGCGTTTCGTCAGAACAC	0.348									Hay-Wells_syndrome	HNSCC(45;0.13)			4	32					0	0	0.001168	0	0
LEPREL1	55214	broad.mit.edu	37	3	189713176	189713176	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:189713176G>A	uc011bsk.1	-	2	924	c.536C>T	c.(535-537)CCT>CTT	p.P179L	LEPREL1_uc003fsg.2_5'UTR	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	179	TPR 2.				collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CATGTGCTCAGGGTTAGCCAC	0.433													4	40					0	0	0.000602	0	0
FGF12	2257	broad.mit.edu	37	3	191888276	191888276	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:191888276G>A	uc003fsx.2	-	4	1410	c.584C>T	c.(583-585)TCA>TTA	p.S195L	FGF12_uc003fsy.2_Missense_Mutation_p.S133L	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	195					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		AAAATGTGATGAGGGCTTGGT	0.438													14	72					0	0	0.001855	0	0
LRRC15	131578	broad.mit.edu	37	3	194080084	194080084	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:194080084G>A	uc003ftu.2	-	2	1775	c.1689C>T	c.(1687-1689)TGC>TGT	p.C563C	LRRC15_uc003ftt.2_Silent_p.C569C	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	563	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TCTTCTTGCAGCAGCAACAGC	0.617													10	61					0	0	0.010729	0	0
LRRC15	131578	broad.mit.edu	37	3	194081252	194081252	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:194081252C>T	uc003ftu.2	-	2	607	c.521G>A	c.(520-522)GGA>GAA	p.G174E	LRRC15_uc003ftt.2_Missense_Mutation_p.G180E	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	174	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		CTTCGTGAGTCCTACCAGGTG	0.592													18	138					0	0	0.012319	0	0
MUC4	4585	broad.mit.edu	37	3	195486082	195486082	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:195486082C>T	uc011bto.1	-	18	14975	c.14515G>A	c.(14515-14517)GGG>AGG	p.G4839R	MUC4_uc003fuz.2_Missense_Mutation_p.G565R|MUC4_uc003fva.2_Missense_Mutation_p.G447R|MUC4_uc003fvb.2_Missense_Mutation_p.G483R|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Missense_Mutation_p.G483R|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Missense_Mutation_p.G447R|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Missense_Mutation_p.G531R|MUC4_uc011bti.1_Missense_Mutation_p.G531R|MUC4_uc011btj.1_Missense_Mutation_p.G708R|MUC4_uc011btk.1_Missense_Mutation_p.G447R|MUC4_uc011btl.1_Missense_Mutation_p.G476R|MUC4_uc011btm.1_Missense_Mutation_p.G656R|MUC4_uc011btn.1_Missense_Mutation_p.G447R|MUC4_uc003fvo.2_Missense_Mutation_p.G731R|MUC4_uc003fvp.2_Missense_Mutation_p.G680R	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1724					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTGGTCTGCCCCTTGTAGGCT	0.537													12	186					0	0	0.013537	0	0
MUC4	4585	broad.mit.edu	37	3	195515992	195515992	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:195515992C>T	uc011bto.1	-	2	2919	c.2459G>A	c.(2458-2460)GGA>GAA	p.G820E	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.G702E	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	825	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGTGGATATTCCTTCGCTTCC	0.582													8	63					0	0	0.004482	0	0
RNF168	165918	broad.mit.edu	37	3	196198767	196198767	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:196198767A>G	uc003fwq.2	-	6	2177	c.1639T>C	c.(1639-1641)TCC>CCC	p.S547P	RNF168_uc010iah.2_Missense_Mutation_p.S380P|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	547					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		GCACTTTTGGATACCTTACAG	0.403													9	98					0	0	0.006214	0	0
LRRC33	375387	broad.mit.edu	37	3	196387757	196387757	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:196387757C>T	uc003fwv.2	+	3	1347	c.1243C>T	c.(1243-1245)CTG>TTG	p.L415L		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	415	Extracellular (Potential).|LRR 14.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CAACCAGCTCCTGGGCGTCCC	0.622													17	88					0	0	0.006122	0	0
PIGX	54965	broad.mit.edu	37	3	196454969	196454969	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:196454969T>G	uc010iaj.2	+	4	652	c.371T>G	c.(370-372)GTG>GGG	p.V124G	PIGX_uc003fwx.3_Missense_Mutation_p.V124G|PIGX_uc011btx.1_RNA	NM_017861	NP_060331	Q8TBF5	PIGX_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	165	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00322)		GCCTCGATTGTGGTCAATAAC	0.473													4	30					0	0	0.001168	0	0
PAK2	5062	broad.mit.edu	37	3	196554117	196554117	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr3:196554117G>T	uc003fwy.3	+	14	1723	c.1401G>T	c.(1399-1401)GAG>GAT	p.E467D		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	467	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		AGAATCCAGAGAAACTTTCCC	0.363													6	53					2.0095e-06	2.17236e-06	0.001984	1	0
PIGG	54872	broad.mit.edu	37	4	524291	524291	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:524291C>T	uc003gak.3	+	11	2464	c.2328C>T	c.(2326-2328)GAC>GAT	p.D776D	PIGG_uc003gaj.3_Silent_p.D768D|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Silent_p.D643D|PIGG_uc003gal.3_Silent_p.D687D	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	776					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						GCACCAAAGACTTACTTAAAT	0.383													20	81					0	0	0.008871	0	0
ATP5I	521	broad.mit.edu	37	4	667114	667114	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:667114C>T	uc003gas.2	-	3	254	c.168G>A	c.(166-168)CGG>CGA	p.R56R	ATP5I_uc003gar.2_RNA|MYL5_uc003gat.2_5'Flank|MYL5_uc003gau.2_5'Flank	NM_007100	NP_009031	P56385	ATP5I_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	56					ATP catabolic process|respiratory electron transport chain		hydrogen ion transmembrane transporter activity				0						CTCTGGCAATCCGTTTCAGTT	0.473													8	44					0	0	0.006214	0	0
TMEM175	84286	broad.mit.edu	37	4	947123	947123	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:947123C>T	uc003gbq.2	+	8	706	c.608C>T	c.(607-609)TCT>TTT	p.S203F	TMEM175_uc010ibl.1_Missense_Mutation_p.S203F|TMEM175_uc003gbp.1_Missense_Mutation_p.S121F|TMEM175_uc003gbr.2_Missense_Mutation_p.S121F|TMEM175_uc003gbu.2_Missense_Mutation_p.S121F|TMEM175_uc003gbs.2_Missense_Mutation_p.S86F|TMEM175_uc003gbt.2_Missense_Mutation_p.S86F|TMEM175_uc003gbv.2_Missense_Mutation_p.S86F|TMEM175_uc010ibm.2_Intron	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	203	Helical; (Potential).					integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GCCATCTTCTCTCTCTTCTTT	0.642													6	28					0	0	0.001168	0	0
POLN	353497	broad.mit.edu	37	4	2083370	2083370	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:2083370G>A	uc003ger.2	-	20	2298	c.2298C>T	c.(2296-2298)TTC>TTT	p.F766F	POLN_uc010icg.1_Silent_p.F214F|POLN_uc010ich.1_Silent_p.F298F	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	766					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			CTTGCACCACGAAGTTCACTG	0.567								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					5	26					0	0	0.000602	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2273462	2273462	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:2273462A>G	uc003gex.1	-	11	2687	c.2368T>C	c.(2368-2370)TGC>CGC	p.C790R	ZFYVE28_uc011bvk.1_Missense_Mutation_p.C720R|ZFYVE28_uc011bvl.1_Missense_Mutation_p.C760R|ZFYVE28_uc003gew.1_Missense_Mutation_p.C676R	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	790					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						GTCTCCTGGCACAGTGCACAG	0.617													12	87					0	0	0.001855	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306678	2306678	+	Silent	SNP	G	A	A	rs61910680	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:2306678G>A	uc003gex.1	-	8	1708	c.1389C>T	c.(1387-1389)CTC>CTT	p.L463L	ZFYVE28_uc011bvk.1_Silent_p.L393L|ZFYVE28_uc011bvl.1_Silent_p.L433L|ZFYVE28_uc003gew.1_Silent_p.L349L	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	463					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						CCTCGGCCTCGAGATTGTTGT	0.697													19	58					0	0	0.007413	0	0
FAM193A	8603	broad.mit.edu	37	4	2701828	2701828	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:2701828C>T	uc010icl.2	+	17	3407	c.3056C>T	c.(3055-3057)CCC>CTC	p.P1019L	FAM193A_uc010ick.2_Missense_Mutation_p.P1219L|FAM193A_uc003gfd.2_Missense_Mutation_p.P1019L|FAM193A_uc011bvm.1_Missense_Mutation_p.P1041L|FAM193A_uc011bvn.1_Missense_Mutation_p.P1019L|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.P873L	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	1019										ovary(3)	3						TTTCTCCTCCCCAAGGAGGTG	0.547													14	71					0	0	0.001855	0	0
HTT	3064	broad.mit.edu	37	4	3221983	3221983	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:3221983C>T	uc011bvq.1	+	54	7468	c.7323C>T	c.(7321-7323)TTC>TTT	p.F2441F		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2439					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CCGTGGAGTTCCTCCAGGAAA	0.512													18	71					0	0	0.010504	0	0
OTOP1	133060	broad.mit.edu	37	4	4198981	4198981	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:4198981G>A	uc003ghp.1	-	5	1610	c.1580C>T	c.(1579-1581)CCA>CTA	p.P527L		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	527					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AAGGCGGACTGGGCTTGGGCT	0.537													7	53					0	0	0.003080	0	0
PPP2R2C	5522	broad.mit.edu	37	4	6374377	6374377	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:6374377C>T	uc003gjc.2	-	5	868	c.498G>A	c.(496-498)AGG>AGA	p.R166R	PPP2R2C_uc003gjb.2_Silent_p.R149R|PPP2R2C_uc011bwd.1_Silent_p.R159R|PPP2R2C_uc011bwe.1_Silent_p.R159R|PPP2R2C_uc003gja.2_Silent_p.R166R|PPP2R2C_uc003gjd.1_Silent_p.R254R	NM_020416	NP_065149	Q9Y2T4	2ABG_HUMAN	gamma isoform of regulatory subunit B55, protein	166					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						TGGCAAAGATCCTCCGAGGGC	0.587													9	83					0	0	0.006214	0	0
MRFAP1	93621	broad.mit.edu	37	4	6642900	6642901	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:6642900_6642901CC>TT	uc003gjg.1	+	2	964_965	c.311_312CC>TT	c.(310-312)GCC>GTT	p.A104V	MRFAP1_uc003gjh.1_Missense_Mutation_p.A104V	NM_033296	NP_150638	Q9Y605	MOFA1_HUMAN	Mof4 family associated protein 1	104	Potential.					nucleus|perinuclear region of cytoplasm	protein binding				0						GAGGAGAAGGCCAAGGAGATTG	0.683													6	53					0	0	0.004672	0	0
TADA2B	93624	broad.mit.edu	37	4	7056555	7056555	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:7056555C>T	uc003gjw.3	+	2	1188	c.1037C>T	c.(1036-1038)CCA>CTA	p.P346L	TADA2B_uc010idi.2_Missense_Mutation_p.P271L	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0						GAGAACCTTCCAGGCTTCGAG	0.512													18	55					0	0	0.007413	0	0
RAB28	9364	broad.mit.edu	37	4	13476015	13476015	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:13476015G>A	uc003gmu.2	-	3	403	c.188C>T	c.(187-189)ACC>ATC	p.T63I	RAB28_uc003gmt.2_Missense_Mutation_p.T63I|RAB28_uc011bwz.1_Missense_Mutation_p.T63I|RAB28_uc003gmv.2_RNA	NM_001017979	NP_001017979	P51157	RAB28_HUMAN	RAB28, member RAS oncogene family isoform 1	63					small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity			ovary(1)|skin(1)	2						AATTTGAAGGGTAACATTCAA	0.303													17	91					0	0	0.004990	0	0
CC2D2A	57545	broad.mit.edu	37	4	15591241	15591241	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:15591241A>T	uc010idv.2	+	34	4498	c.4253A>T	c.(4252-4254)TAT>TTT	p.Y1418F	CC2D2A_uc003gnx.2_Missense_Mutation_p.Y1310F|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	1418					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						GGACATTTTTATGGACAATTT	0.378													14	54					0	0	0.002450	0	0
LDB2	9079	broad.mit.edu	37	4	16510278	16510278	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:16510278C>T	uc003goz.2	-	7	1087	c.771G>A	c.(769-771)CGG>CGA	p.R257R	LDB2_uc003gpa.2_Silent_p.R257R|LDB2_uc003gpb.2_Silent_p.R257R|LDB2_uc011bxh.1_Silent_p.R229R|LDB2_uc010iee.2_Silent_p.R257R|LDB2_uc003goy.2_Silent_p.R132R|LDB2_uc011bxi.1_Silent_p.R133R	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	257							LIM domain binding|transcription cofactor activity				0						TCCTTTTTCTCCGTTTGGTTG	0.478													4	64					0	0	0.000602	0	0
KCNIP4	80333	broad.mit.edu	37	4	20852243	20852243	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:20852243C>T	uc003gqe.2	-	2	244	c.160G>A	c.(160-162)GAA>AAA	p.E54K	KCNIP4_uc003gqf.1_Missense_Mutation_p.E50K|KCNIP4_uc003gqg.1_Missense_Mutation_p.E9K|KCNIP4_uc003gqh.1_Missense_Mutation_p.E46K|KCNIP4_uc003gqi.1_Missense_Mutation_p.E9K|KCNIP4_uc010iel.2_Missense_Mutation_p.E51K|KCNIP4_uc003gqd.3_Missense_Mutation_p.E34K	NM_147182	NP_671711	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4 isoform 3	71	EF-hand 1; degenerate.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)				TCAAGGGCTTCAGGCCGATGC	0.468													16	31					0	0	0.004990	0	0
LGI2	55203	broad.mit.edu	37	4	25005516	25005516	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:25005516G>A	uc003grf.2	-	8	1294	c.1195C>T	c.(1195-1197)CTC>TTC	p.L399F		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	399	EAR 4.					extracellular region					0		Breast(46;0.173)				TTCCACTGGAGGATGATGGGG	0.517													38	111					0	0	0.005524	0	0
PI4K2B	55300	broad.mit.edu	37	4	25256861	25256861	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:25256861C>T	uc003grk.2	+	3	731	c.598C>T	c.(598-600)CAT>TAT	p.H200Y	PI4K2B_uc011bxs.1_Missense_Mutation_p.H104Y	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta	200	PI3K/PI4K.					cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			ovary(2)|skin(2)	4		Breast(46;0.173)				CAACAAGCTTCATCTGAGCAT	0.423													26	46					0	0	0.008361	0	0
RBM47	54502	broad.mit.edu	37	4	40428109	40428109	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:40428109G>A	uc003gvc.2	-	7	2304	c.1594C>T	c.(1594-1596)CCT>TCT	p.P532S	RBM47_uc003gvd.2_Missense_Mutation_p.P463S|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.P494S	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	532	Ala-rich.					nucleus	nucleotide binding|RNA binding			breast(3)	3						CCGGCAGTAGGAATTCTCTGA	0.562													5	37					0	0	0.001168	0	0
NSUN7	79730	broad.mit.edu	37	4	40763290	40763290	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:40763290G>A	uc003gvj.3	+	4	955	c.460G>A	c.(460-462)GTT>ATT	p.V154I	NSUN7_uc003gvh.2_Missense_Mutation_p.V154I|NSUN7_uc003gvi.3_Missense_Mutation_p.V154I	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						CATATCAGAAGTTCAAGAAGT	0.308													13	104					0	0	0.002450	0	0
NSUN7	79730	broad.mit.edu	37	4	40778076	40778076	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:40778076G>A	uc003gvj.3	+	7	1331	c.836G>A	c.(835-837)CGA>CAA	p.R279Q	NSUN7_uc003gvi.3_Missense_Mutation_p.R279Q	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						GACAAATCTCGAAGTCTTGCT	0.348													7	21					0	0	0.003080	0	0
LIMCH1	22998	broad.mit.edu	37	4	41652476	41652476	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:41652476C>A	uc003gvu.3	+	13	1786	c.1732C>A	c.(1732-1734)CCC>ACC	p.P578T	LIMCH1_uc003gvv.3_Missense_Mutation_p.P578T|LIMCH1_uc003gvw.3_Missense_Mutation_p.P578T|LIMCH1_uc003gvx.3_Missense_Mutation_p.P566T|LIMCH1_uc003gwe.3_Missense_Mutation_p.P578T|LIMCH1_uc003gvy.3_Missense_Mutation_p.P407T|LIMCH1_uc003gwa.3_Missense_Mutation_p.P419T|LIMCH1_uc003gvz.3_Missense_Mutation_p.P963T|LIMCH1_uc011byu.1_Missense_Mutation_p.P412T|LIMCH1_uc003gwc.3_Missense_Mutation_p.P424T|LIMCH1_uc003gwd.3_Missense_Mutation_p.P412T|LIMCH1_uc011byv.1_Missense_Mutation_p.P329T	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	578					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						AAGAGAGTGTCCCACGGTGGC	0.493													10	20					1.58986e-06	1.71927e-06	0.008291	1	0
LIMCH1	22998	broad.mit.edu	37	4	41691626	41691626	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:41691626C>T	uc003gvu.3	+	25	3151	c.3097C>T	c.(3097-3099)CTC>TTC	p.L1033F	LIMCH1_uc003gvv.3_Missense_Mutation_p.L1007F|LIMCH1_uc003gvw.3_Missense_Mutation_p.L1006F|LIMCH1_uc003gvx.3_Missense_Mutation_p.L1019F|LIMCH1_uc003gwe.3_Missense_Mutation_p.L930F|LIMCH1_uc003gvy.3_Missense_Mutation_p.L835F|LIMCH1_uc003gwa.3_Missense_Mutation_p.L847F|LIMCH1_uc003gvz.3_Missense_Mutation_p.L1417F|LIMCH1_uc011byu.1_Missense_Mutation_p.L866F|LIMCH1_uc003gwc.3_Missense_Mutation_p.L852F|LIMCH1_uc003gwd.3_Missense_Mutation_p.L840F|LIMCH1_uc011byv.1_Missense_Mutation_p.L783F|LIMCH1_uc011byw.1_Missense_Mutation_p.L306F	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	1033	LIM zinc-binding.				actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						GACCCTCAATCTCTATTTTCA	0.433													5	53					0	0	0.001984	0	0
SHISA3	152573	broad.mit.edu	37	4	42403154	42403154	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:42403154C>T	uc003gwp.2	+	2	621	c.403C>T	c.(403-405)CGC>TGC	p.R135C		NM_001080505	NP_001073974	A0PJX4	SHSA3_HUMAN	shisa homolog 3 precursor	135	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|skin(1)	2						GCAGCCAATCCGCTTCTCACT	0.592													16	198					0	0	0.008871	0	0
ATP8A1	10396	broad.mit.edu	37	4	42466951	42466951	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:42466951C>T	uc003gwr.2	-	26	2699	c.2467G>A	c.(2467-2469)GGC>AGC	p.G823S	ATP8A1_uc003gwq.2_Missense_Mutation_p.G49S|ATP8A1_uc003gws.2_Missense_Mutation_p.G808S	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	823	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	GCCTGCAGGCCTTCATTGCCA	0.458													7	24					0	0	0.003080	0	0
GRXCR1	389207	broad.mit.edu	37	4	42895295	42895295	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:42895295G>A	uc003gwt.2	+	1	12	c.12G>A	c.(10-12)AGG>AGA	p.R4R		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	4					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						TGCTTAAAAGGGAGATGAAGC	0.502													8	49					0	0	0.003080	0	0
GRXCR1	389207	broad.mit.edu	37	4	43032513	43032513	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:43032513T>C	uc003gwt.2	+	4	829	c.829T>C	c.(829-831)TGC>CGC	p.C277R		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	277					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						GTGTACGGCTTGCAATGAAAA	0.438													12	116					0	0	0.010729	0	0
ATP10D	57205	broad.mit.edu	37	4	47548757	47548757	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:47548757C>T	uc003gxk.1	+	10	1677	c.1513C>T	c.(1513-1515)CAT>TAT	p.H505Y	ATP10D_uc003gxl.1_5'UTR|ATP10D_uc003gxj.3_Missense_Mutation_p.H490Y	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	505	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CAGGACAGTTCATAATGGGCC	0.478													24	65					0	0	0.004656	0	0
ATP10D	57205	broad.mit.edu	37	4	47563038	47563038	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:47563038G>A	uc003gxk.1	+	14	2778	c.2614G>A	c.(2614-2616)GAA>AAA	p.E872K	ATP10D_uc003gxl.1_Missense_Mutation_p.E120K	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	872	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						TGACAACAGGGAAGAATTACT	0.383													10	69					0	0	0.006214	0	0
ATP10D	57205	broad.mit.edu	37	4	47571048	47571048	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:47571048C>T	uc003gxk.1	+	16	3212	c.3048C>T	c.(3046-3048)TTC>TTT	p.F1016F	ATP10D_uc003gxl.1_Silent_p.F264F	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1016	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						AAAAGCAGTTCCTGGAACTGA	0.547													6	44					0	0	0.001984	0	0
ATP10D	57205	broad.mit.edu	37	4	47593145	47593145	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:47593145G>A	uc003gxk.1	+	23	4192	c.4028G>A	c.(4027-4029)AGG>AAG	p.R1343K	ATP10D_uc003gxl.1_Missense_Mutation_p.R591K	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1343	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CCAGAGGAGAGGACTAAAGCT	0.458													9	69					0	0	0.004482	0	0
CORIN	10699	broad.mit.edu	37	4	47605486	47605486	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:47605486G>A	uc003gxm.2	-	20	2833	c.2740C>T	c.(2740-2742)CCC>TCC	p.P914S	CORIN_uc011bzf.1_Missense_Mutation_p.P775S|CORIN_uc011bzg.1_Missense_Mutation_p.P847S	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	914	Extracellular (Potential).|Peptidase S1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						TCCGGGTTGGGCAAGCAGACA	0.507													4	46					0	0	0.009096	0	0
FRYL	285527	broad.mit.edu	37	4	48555248	48555248	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:48555248G>A	uc003gyh.1	-	36	5024	c.4419C>T	c.(4417-4419)ATC>ATT	p.I1473I	FRYL_uc003gyk.2_Silent_p.I1473I|FRYL_uc003gyg.1_Silent_p.I169I|FRYL_uc003gyi.1_Silent_p.I362I	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1473					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TGACAGAAGGGATTTTATAGC	0.328													5	50					0	0	0.001168	0	0
OCIAD2	132299	broad.mit.edu	37	4	48894821	48894821	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:48894821G>A	uc003gyt.2	-	6	554	c.351C>T	c.(349-351)CTC>CTT	p.L117L	OCIAD2_uc003gyu.2_Intron	NM_001014446	NP_001014446	Q56VL3	OCAD2_HUMAN	OCIA domain containing 2 isoform 1	117	OCIA.					endosome					0						CAGCCCCACGGAGCTGATCTT	0.383													15	144					0	0	0.007413	0	0
CWH43	80157	broad.mit.edu	37	4	48994092	48994092	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:48994092G>A	uc003gyv.2	+	4	678	c.496G>A	c.(496-498)GAT>AAT	p.D166N	CWH43_uc011bzl.1_Missense_Mutation_p.D139N	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	166					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						AGCCACACTTGATCGTATTGG	0.373													10	29					0	0	0.008291	0	0
LRRC66	339977	broad.mit.edu	37	4	52861180	52861180	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:52861180G>A	uc003gzi.2	-	4	2021	c.2008C>T	c.(2008-2010)CCT>TCT	p.P670S		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	670						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CATCTTGGAGGAAAGACTGAT	0.562													19	37					0	0	0.008871	0	0
LRRC66	339977	broad.mit.edu	37	4	52861909	52861909	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:52861909C>T	uc003gzi.2	-	4	1292	c.1279G>A	c.(1279-1281)GAT>AAT	p.D427N		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	427						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						TCCATGTCATCGTAGAAGCCC	0.537													7	99					0	0	0.003080	0	0
LNX1	84708	broad.mit.edu	37	4	54342990	54342990	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:54342990C>T	uc003hag.3	-	9	2078	c.1822G>A	c.(1822-1824)GAC>AAC	p.D608N	PDGFRA_uc003haa.2_Intron|LNX1_uc003haf.3_Missense_Mutation_p.D512N|LNX1_uc003hah.3_RNA	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a	608						cytoplasm	zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TGGTTGGAGTCCAGGGCTGCT	0.522													14	81					0	0	0.004990	0	0
NMU	10874	broad.mit.edu	37	4	56471515	56471515	+	Missense_Mutation	SNP	G	A	A	rs138342873		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:56471515G>A	uc003hbc.2	-	7	468	c.362C>T	c.(361-363)TCG>TTG	p.S121L	NMU_uc003hbd.1_Intron|NMU_uc010igv.1_RNA|NMU_uc010igw.1_Missense_Mutation_p.S36L|NMU_uc010igx.1_Intron	NM_006681	NP_006672	P48645	NMU_HUMAN	neuromedin U precursor	121					neuropeptide signaling pathway	extracellular region					0	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		CACAACTGACGACTGAGAGGA	0.453													6	32					0	0	0.001168	0	0
AASDH	132949	broad.mit.edu	37	4	57216119	57216119	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:57216119C>T	uc003hbn.2	-	11	1951	c.1798G>A	c.(1798-1800)GAA>AAA	p.E600K	AASDH_uc010ihb.2_Missense_Mutation_p.E115K|AASDH_uc011caa.1_Missense_Mutation_p.E447K|AASDH_uc003hbo.2_Missense_Mutation_p.E500K|AASDH_uc011cab.1_Missense_Mutation_p.E115K|AASDH_uc010ihc.2_Missense_Mutation_p.E600K|AASDH_uc003hbp.2_Missense_Mutation_p.E600K	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	600	Acyl carrier.				fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				ACAAGTTTTTCAATCTCACTG	0.408													4	28					0	0	0.000602	0	0
SPINK2	6691	broad.mit.edu	37	4	57686735	57686735	+	Silent	SNP	G	A	A	rs114989645	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:57686735G>A	uc003hcg.1	-	2	131	c.66C>T	c.(64-66)ATC>ATT	p.I22I		NM_021114	NP_066937	P20155	ISK2_HUMAN	serine protease inhibitor, Kazal type 2	22						extracellular region	serine-type endopeptidase inhibitor activity				0	Glioma(25;0.08)|all_neural(26;0.181)					CAAATTGAGGGATCAGAGAGG	0.338													4	41					0	0	0.009096	0	0
REST	5978	broad.mit.edu	37	4	57777225	57777225	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:57777225C>T	uc003hch.2	+	2	768	c.421C>T	c.(421-423)CCC>TCC	p.P141S	REST_uc003hci.2_Missense_Mutation_p.P141S|REST_uc003hcj.1_Missense_Mutation_p.P141S|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	141					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					TAAAGATCTTCCCCCTGAAAC	0.458													12	52					0	0	0.013537	0	0
IGFBP7	3490	broad.mit.edu	37	4	57898610	57898610	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:57898610C>T	uc003hcn.2	-	4	833	c.811G>A	c.(811-813)GAA>AAA	p.E271K	IGFBP7_uc011cag.1_Missense_Mutation_p.E271K	NM_001553	NP_001544	Q16270	IBP7_HUMAN	insulin-like growth factor binding protein 7	271					cell adhesion|negative regulation of cell proliferation|regulation of cell growth	extracellular space	insulin-like growth factor binding			lung(2)|central_nervous_system(1)	3	Glioma(25;0.08)|all_neural(26;0.181)				Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACTGGTATTTCATGTAAGGCA	0.363													6	47					0	0	0.001168	0	0
EPHA5	2044	broad.mit.edu	37	4	66509130	66509130	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:66509130G>A	uc003hcy.2	-	2	390	c.197C>T	c.(196-198)TCA>TTA	p.S66L	EPHA5_uc003hcx.2_5'UTR|EPHA5_uc003hcz.2_Missense_Mutation_p.S66L|EPHA5_uc011cah.1_Missense_Mutation_p.S66L|EPHA5_uc011cai.1_Missense_Mutation_p.S66L|EPHA5_uc003hda.2_Missense_Mutation_p.S66L	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	66	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GACAGTGCGTGAATCCAATAA	0.313										TSP Lung(17;0.13)			16	28					0	0	0.007413	0	0
Unknown	0	broad.mit.edu	37	4	69343263	69343263	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:69343263G>C	uc003hdz.3	+	8	948	c.884G>C	c.(883-885)AGA>ACA	p.R295T		NM_014058	NP_054777			transmembrane protease, serine 11E																		GCAGTACATAGAGTTTGTCTC	0.413													17	202					0	0	0.004007	0	0
UGT2B15	7366	broad.mit.edu	37	4	69512998	69512998	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:69512998C>T	uc011cal.1	-	6	1455	c.1417G>A	c.(1417-1419)GGA>AGA	p.G473R		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	473					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						TGCTTGGCTCCTTTGTGGCGC	0.483													20	89					0	0	0.012319	0	0
UGT2B10	7365	broad.mit.edu	37	4	69696584	69696584	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:69696584G>A	uc003hee.2	+	6	1599	c.1574G>A	c.(1573-1575)GGA>GAA	p.G525E	UGT2B10_uc011cam.1_Missense_Mutation_p.G441E	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	525					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GGAAAGAAGGGAAAAAGGGAT	0.378													7	47					0	0	0.001984	0	0
UGT2B7	7364	broad.mit.edu	37	4	69962779	69962779	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:69962779G>A	uc003heg.3	+	1	587	c.541G>A	c.(541-543)GAA>AAA	p.E181K	UGT2B7_uc010ihq.2_Missense_Mutation_p.E181K	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	181					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						CTACACTTTTGAAAAGCATAG	0.393													9	75					0	0	0.004482	0	0
UGT2B11	10720	broad.mit.edu	37	4	70066279	70066279	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:70066279G>T	uc003heh.2	-	6	1478	c.1469C>A	c.(1468-1470)TCT>TAT	p.S490Y	uc003hei.1_RNA	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	490					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						CACATCCAAAGAGTGGTACTG	0.463													10	97					0.00136819	0.00147242	0.013537	1	0
HTN1	3346	broad.mit.edu	37	4	70920059	70920059	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:70920059G>A	uc003hex.2	+	3	139	c.72G>A	c.(70-72)AAG>AAA	p.K24K		NM_002159	NP_002150	P15515	HIS1_HUMAN	histatin 1 precursor	24					biomineral tissue development|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			skin(1)	1						CACATGAAAAGGTAAGACATT	0.239													6	11					0	0	0.003080	0	0
SMR3A	26952	broad.mit.edu	37	4	71232569	71232569	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:71232569G>A	uc003hfg.1	+	3	344	c.263G>A	c.(262-264)AGA>AAA	p.R88K	SMR3B_uc011cas.1_Intron	NM_012390	NP_036522	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3	88	Pro-rich.					extracellular region					0		all_hematologic(202;0.196)				GGTCCAGGGAGAATTCAATCA	0.552													32	63					0	0	0.013726	0	0
PROL1	58503	broad.mit.edu	37	4	71275270	71275270	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:71275270C>T	uc003hfi.2	+	3	399	c.225C>T	c.(223-225)TTC>TTT	p.F75F		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	75	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				CATCTTCTTTCTCTCGATTTA	0.463													21	132					0	0	0.002780	0	0
ALB	213	broad.mit.edu	37	4	74283949	74283949	+	Missense_Mutation	SNP	G	A	A	rs75523493		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:74283949G>A	uc003hgs.3	+	12	1646	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K	ALB_uc003hgw.3_Missense_Mutation_p.E333K|ALB_uc011cbe.1_Missense_Mutation_p.E204K|ALB_uc003hgt.3_Missense_Mutation_p.E525K|ALB_uc010iii.2_Missense_Mutation_p.E410K|ALB_uc003hgu.3_Missense_Mutation_p.E375K|ALB_uc003hgv.3_Missense_Mutation_p.E204K|ALB_uc011cbf.1_Missense_Mutation_p.E415K|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Missense_Mutation_p.E204K	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	525	Albumin 3.		E -> K (in Manaus-1/Adana/Lambadi/ Vancouver).	E -> Q (in Ref. 18; AA sequence).	bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CGTTCCCAAAGAGTTTAATGC	0.428													4	54					0	0	0.009096	0	0
AFM	173	broad.mit.edu	37	4	74354448	74354448	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:74354448G>A	uc003hhb.2	+	7	846	c.815G>A	c.(814-816)GGG>GAG	p.G272E		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	272	Albumin 2.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGCTGTGAAGGGGATGTTGTG	0.358													9	80					0	0	0.006214	0	0
RASSF6	166824	broad.mit.edu	37	4	74453617	74453617	+	Missense_Mutation	SNP	G	A	A	rs142555062		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:74453617G>A	uc003hhd.1	-	5	541	c.418C>T	c.(418-420)CGT>TGT	p.R140C	RASSF6_uc003hhc.1_Missense_Mutation_p.R108C|RASSF6_uc010iik.1_Missense_Mutation_p.R108C|RASSF6_uc010iil.1_Missense_Mutation_p.R96C	NM_201431	NP_958834	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family 6	140					apoptosis|signal transduction		protein binding	p.R140C(1)		pancreas(2)	2	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			TCACTAATACGATAGAGATCG	0.383													5	55					0	0	0.003080	0	0
CXCL9	4283	broad.mit.edu	37	4	76928579	76928579	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:76928579G>A	uc003hjh.1	-	1	63	c.24C>T	c.(22-24)TTC>TTT	p.F8F		NM_002416	NP_002407	Q07325	CXCL9_HUMAN	small inducible cytokine B9 precursor	8					cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGCCCAAGAGGAAAAGAACAC	0.398													8	87					0	0	0.004482	0	0
ART3	419	broad.mit.edu	37	4	77003000	77003000	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:77003000G>A	uc003hjo.2	+	3	212	c.93G>A	c.(91-93)ATG>ATA	p.M31I	ART3_uc003hji.2_Missense_Mutation_p.M31I|ART3_uc003hjj.2_Missense_Mutation_p.M31I|ART3_uc003hjk.2_Missense_Mutation_p.M31I|ART3_uc010ija.1_Missense_Mutation_p.M31I|ART3_uc003hjn.2_Missense_Mutation_p.M31I|ART3_uc003hjp.2_Intron|ART3_uc010ijb.2_Intron|ART3_uc003hjq.2_Intron|ART3_uc003hjr.2_Missense_Mutation_p.M1I|ART3_uc010ijc.2_Missense_Mutation_p.M1I|ART3_uc010ijd.2_Missense_Mutation_p.M1I	NM_001130016	NP_001123488	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3 isoform a	31					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			ovary(2)	2			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGTTAGACATGGCAGATAATG	0.373													24	79					0	0	0.007291	0	0
FRAS1	80144	broad.mit.edu	37	4	79369304	79369304	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:79369304G>A	uc003hlb.2	+	44	6548	c.6108G>A	c.(6106-6108)GGG>GGA	p.G2036G		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2035	CSPG 8.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TCCTAGCTGGGCTGGTTGGGT	0.542													5	45					0	0	0.001168	0	0
TMEM150C	441027	broad.mit.edu	37	4	83417287	83417287	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:83417287C>T	uc003hmy.1	-	6	375	c.297G>A	c.(295-297)CTG>CTA	p.L99L	TMEM150C_uc011ccj.1_Silent_p.L129L	NM_001080506	NP_001073975	B9EJG8	T150C_HUMAN	transmembrane protein 150C	99	Helical; (Potential).					integral to membrane				ovary(1)	1						CACTAATATTCAGCCACGGGT	0.423													5	44					0	0	0.000602	0	0
SEC31A	22872	broad.mit.edu	37	4	83748524	83748524	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:83748524G>A	uc003hnf.2	-	24	3453	c.3289C>T	c.(3289-3291)CAG>TAG	p.Q1097*	SEC31A_uc003hnd.2_Nonsense_Mutation_p.Q266*|SEC31A_uc003hne.2_Nonsense_Mutation_p.Q846*|SEC31A_uc011ccl.1_Nonsense_Mutation_p.Q1043*|SEC31A_uc003hnl.2_Nonsense_Mutation_p.Q944*|SEC31A_uc003hng.2_Nonsense_Mutation_p.Q1082*|SEC31A_uc003hnh.2_Nonsense_Mutation_p.Q1097*|SEC31A_uc003hni.2_Nonsense_Mutation_p.Q983*|SEC31A_uc003hnj.2_Nonsense_Mutation_p.Q1058*|SEC31A_uc011ccm.1_Nonsense_Mutation_p.Q1077*|SEC31A_uc011ccn.1_Nonsense_Mutation_p.Q1082*|SEC31A_uc003hnk.2_Nonsense_Mutation_p.Q1058*|SEC31A_uc003hnm.2_Nonsense_Mutation_p.Q1097*	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	1097	Interaction with PDCD6.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				ACTGTTACCTGGAAGGTATTT	0.398													27	134					0	0	0.003271	0	0
WDFY3	23001	broad.mit.edu	37	4	85623601	85623601	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:85623601G>A	uc003hpd.2	-	56	8909	c.8501C>T	c.(8500-8502)TCA>TTA	p.S2834L	WDFY3_uc003hpe.1_Missense_Mutation_p.S445L	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2834	BEACH.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CTTTGACGCTGAATACCAGGC	0.458													8	32					0	0	0.004482	0	0
IBSP	3381	broad.mit.edu	37	4	88733012	88733012	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:88733012G>A	uc003hqx.3	+	7	1002	c.904G>A	c.(904-906)GGA>AGA	p.G302R		NM_004967	NP_004958	P21815	SIAL_HUMAN	integrin-binding sialoprotein precursor	302					biomineral tissue development|cell adhesion|ossification						0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		CTACTTTAAAGGACAAGGCTA	0.463													6	83					0	0	0.004482	0	0
ABCG2	9429	broad.mit.edu	37	4	89018718	89018718	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:89018718T>G	uc003hrg.2	-	13	2027	c.1534A>C	c.(1534-1536)ACC>CCC	p.T512P	ABCG2_uc003hrh.2_Missense_Mutation_p.T512P|ABCG2_uc003hrf.2_Missense_Mutation_p.T380P	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	512	ABC transmembrane type-2.|Helical; (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	ATCATAAGGGTAAACATCATA	0.458													8	28					0	0	0.004482	0	0
ABCG2	9429	broad.mit.edu	37	4	89042886	89042886	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:89042886C>T	uc003hrg.2	-	6	1083	c.590G>A	c.(589-591)GGA>GAA	p.G197E	ABCG2_uc003hrh.2_Missense_Mutation_p.G197E|ABCG2_uc003hrf.2_Missense_Mutation_p.G67E	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	197	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	AAGCTCCATTCCTATACTAGT	0.408													11	35					0	0	0.010729	0	0
GRID2	2895	broad.mit.edu	37	4	94137934	94137934	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:94137934G>A	uc011cdt.1	+	6	1093	c.835G>A	c.(835-837)GGA>AGA	p.G279R	GRID2_uc010ikx.2_Missense_Mutation_p.G279R|GRID2_uc011cdu.1_Missense_Mutation_p.G184R|GRID2_uc010ikz.1_5'UTR	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	279	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AAGGTCAATTGGAAGGTTAAC	0.398													7	81					0	0	0.003080	0	0
ADH4	127	broad.mit.edu	37	4	100052836	100052836	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:100052836C>T	uc003hun.2	-	6	738	c.662G>A	c.(661-663)GGA>GAA	p.G221E	uc003hum.1_Intron|ADH4_uc011ced.1_Missense_Mutation_p.G240E	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	221					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	TCTGGAAGCTCCTGCTGCTTT	0.468													4	44					0	0	0.009096	0	0
ADH6	130	broad.mit.edu	37	4	100134803	100134803	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:100134803G>A	uc003hup.3	-	3	316	c.222C>T	c.(220-222)ATC>ATT	p.I74I	uc003hum.1_Intron|ADH6_uc003huo.2_Silent_p.I74I|ADH6_uc011cef.1_Intron|ADH6_uc010ile.2_Silent_p.I74I	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	74					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	TACTCTCAACGATTCCAGCCC	0.478													18	42					0	0	0.006122	0	0
ADH1A	124	broad.mit.edu	37	4	100203562	100203562	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:100203562C>T	uc003hur.1	-	6	840	c.769G>A	c.(769-771)GAA>AAA	p.E257K	uc003hum.1_Intron|ADH1A_uc011ceg.1_Missense_Mutation_p.E257K|ADH1A_uc010ilf.1_Missense_Mutation_p.E48K	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit	257					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	TCAGTCATTTCCTTTAGCACC	0.463													67	253					0	0	0.014410	0	0
ADH1C	126	broad.mit.edu	37	4	100268961	100268961	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:100268961G>A	uc003huu.2	-	2	146	c.61C>T	c.(61-63)CCC>TCC	p.P21S		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	21					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	ATGGAAAAGGGTTTCTTTAAC	0.358									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				5	46					0	0	0.001984	0	0
MTTP	4547	broad.mit.edu	37	4	100512405	100512405	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:100512405G>A	uc003hvc.3	+	6	771	c.515G>A	c.(514-516)GGA>GAA	p.G172E	MTTP_uc011cej.1_Missense_Mutation_p.G199E	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	172	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	GATATCTCTGGAAATTGTAAA	0.413													16	42					0	0	0.004990	0	0
DNAJB14	79982	broad.mit.edu	37	4	100822258	100822258	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:100822258C>T	uc003hvl.2	-	8	1218	c.1067G>A	c.(1066-1068)AGG>AAG	p.R356K	DNAJB14_uc003hvk.2_Missense_Mutation_p.R271K|DNAJB14_uc010ili.2_Missense_Mutation_p.R289K	NM_001031723	NP_001026893	Q8TBM8	DJB14_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 14	356					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding				0				OV - Ovarian serous cystadenocarcinoma(123;4.59e-09)		ATCTGCCTTCCTTCGGAGTCG	0.348													6	65					0	0	0.001168	0	0
BDH2	56898	broad.mit.edu	37	4	104012420	104012420	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:104012420G>A	uc003hwz.2	-	5	376	c.271C>T	c.(271-273)CTG>TTG	p.L91L	BDH2_uc003hxa.2_RNA	NM_020139	NP_064524	Q9BUT1	BDH2_HUMAN	3-hydroxybutyrate dehydrogenase, type 2	91					fatty acid beta-oxidation|heme metabolic process|iron ion homeostasis|siderophore biosynthetic process	cytoplasm	3-hydroxybutyrate dehydrogenase activity|NAD binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.02e-08)		TCACAATCCAGGACAGTTCCA	0.393													11	27					0	0	0.008291	0	0
CENPE	1062	broad.mit.edu	37	4	104066729	104066729	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:104066729G>A	uc003hxb.1	-	31	4613	c.4523C>T	c.(4522-4524)TCA>TTA	p.S1508L	CENPE_uc003hxc.1_Missense_Mutation_p.S1483L	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1508	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTGAATGGTTGATATTTCAGT	0.368													12	62					0	0	0.001855	0	0
CENPE	1062	broad.mit.edu	37	4	104080030	104080030	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:104080030G>A	uc003hxb.1	-	23	2705	c.2615C>T	c.(2614-2616)ACC>ATC	p.T872I	CENPE_uc003hxc.1_Missense_Mutation_p.T847I	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	872	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		AAGTTCTTGGGTCTTGTAAGA	0.373													10	28					0	0	0.006214	0	0
TACR3	6870	broad.mit.edu	37	4	104510988	104510988	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:104510988C>T	uc003hxe.1	-	5	1392	c.1249G>A	c.(1249-1251)GAT>AAT	p.D417N		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	417	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GTGTCTGCATCGTTGGGGTCA	0.527													38	104					0	0	0.010771	0	0
CFI	3426	broad.mit.edu	37	4	110663747	110663747	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:110663747G>A	uc003hzr.3	-	12	1642	c.1434C>T	c.(1432-1434)AAC>AAT	p.N478N	CFI_uc003hzq.2_Silent_p.N275N|CFI_uc011cft.1_Silent_p.N486N|CFI_uc003hzs.3_Silent_p.N471N	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	478	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		AGACTCTTTCGTTATCTAAAC	0.333													5	49					0	0	0.001168	0	0
EGF	1950	broad.mit.edu	37	4	110909851	110909851	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:110909851G>A	uc003hzy.3	+	18	3172	c.2720G>A	c.(2719-2721)GGG>GAG	p.G907E	EGF_uc011cfu.1_Missense_Mutation_p.G865E|EGF_uc011cfv.1_Missense_Mutation_p.G907E|EGF_uc010imk.2_Intron	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	907	EGF-like 7; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CAAGGAGATGGGATTCACTGT	0.567													8	73					0	0	0.006214	0	0
ENPEP	2028	broad.mit.edu	37	4	111470973	111470973	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:111470973C>T	uc003iab.3	+	17	2774	c.2432C>T	c.(2431-2433)TCA>TTA	p.S811L		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	811	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CAGAAAACTTCATTAGCTCAA	0.383													8	32					0	0	0.004482	0	0
ALPK1	80216	broad.mit.edu	37	4	113303585	113303585	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:113303585C>T	uc003iap.3	+	4	432	c.153C>T	c.(151-153)ATC>ATT	p.I51I	ALPK1_uc003iam.2_Silent_p.I51I|ALPK1_uc011cfw.1_RNA|ALPK1_uc003ian.3_Silent_p.I51I|ALPK1_uc011cfx.1_Intron|ALPK1_uc003iao.3_RNA|ALPK1_uc003iaq.2_5'UTR|ALPK1_uc010imo.2_5'UTR	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	51							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		GGACCCTGATCCAGGAGGCAA	0.478													10	17					0	0	0.006214	0	0
ALPK1	80216	broad.mit.edu	37	4	113352924	113352924	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:113352924G>A	uc003iap.3	+	11	2500	c.2221G>A	c.(2221-2223)GAA>AAA	p.E741K	ALPK1_uc003ian.3_Missense_Mutation_p.E741K|ALPK1_uc011cfx.1_Missense_Mutation_p.E663K|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Missense_Mutation_p.E569K	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	741							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AGTCCAAAAAGAAGAAGCCTT	0.448													4	58					0	0	0.009096	0	0
CAMK2D	817	broad.mit.edu	37	4	114381320	114381320	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:114381320C>T	uc003ibi.2	-	16	2046	c.1187G>A	c.(1186-1188)CGA>CAA	p.R396Q	CAMK2D_uc003ibj.2_Missense_Mutation_p.R396Q|CAMK2D_uc003ibk.2_Missense_Mutation_p.R396Q|CAMK2D_uc003ibo.3_Missense_Mutation_p.R430Q|CAMK2D_uc003ibm.2_Missense_Mutation_p.R410Q|CAMK2D_uc003ibn.2_Missense_Mutation_p.R407Q|CAMK2D_uc003ibl.2_Missense_Mutation_p.R396Q	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	396					interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		AAAGTAGAATCGGTGAAAATC	0.328													27	73					0	0	0.010818	0	0
CAMK2D	817	broad.mit.edu	37	4	114452437	114452437	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:114452437C>T	uc003ibi.2	-	8	1395	c.536G>A	c.(535-537)GGA>GAA	p.G179E	CAMK2D_uc003ibj.2_Missense_Mutation_p.G179E|CAMK2D_uc003ibk.2_Missense_Mutation_p.G179E|CAMK2D_uc003ibo.3_Missense_Mutation_p.G179E|CAMK2D_uc003ibm.2_Missense_Mutation_p.G179E|CAMK2D_uc003ibn.2_Missense_Mutation_p.G179E|CAMK2D_uc003ibl.2_Missense_Mutation_p.G179E	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	179	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		AGAAAGATATCCAGGTGTGCC	0.358													6	15					0	0	0.001984	0	0
NDST4	64579	broad.mit.edu	37	4	115760697	115760697	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:115760697C>T	uc003ibu.2	-	11	2802	c.2123G>A	c.(2122-2124)CGA>CAA	p.R708Q	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	708	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TTCATGTGATCGTTGGTGCTT	0.279													5	40					0	0	0.001984	0	0
NDST4	64579	broad.mit.edu	37	4	115767065	115767065	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:115767065G>A	uc003ibu.2	-	10	2708	c.2029C>T	c.(2029-2031)CCA>TCA	p.P677S	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	677	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GCTCGTCTTGGAGCTTCTTCC	0.458													19	53					0	0	0.008871	0	0
NDST4	64579	broad.mit.edu	37	4	115891729	115891729	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:115891729C>T	uc003ibu.2	-	4	1757	c.1078G>A	c.(1078-1080)GAA>AAA	p.E360K	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	360	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CCTTCATCTTCCTCTTCAGTC	0.373													5	22					0	0	0.000602	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951608	119951608	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:119951608G>A	uc003icm.3	+	4	1874	c.1678G>A	c.(1678-1680)GGT>AGT	p.G560S	SYNPO2_uc010ina.2_Missense_Mutation_p.G560S|SYNPO2_uc010inb.2_Missense_Mutation_p.G560S|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.G488S	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	560						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						GGTGAGTCATGGTCTTGGCCA	0.517													14	25					0	0	0.007413	0	0
USP53	54532	broad.mit.edu	37	4	120192649	120192649	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:120192649A>T	uc003ics.3	+	15	2700	c.1634A>T	c.(1633-1635)AAA>ATA	p.K545I	USP53_uc003icr.3_Missense_Mutation_p.K545I|USP53_uc003icu.3_Missense_Mutation_p.K168I|USP53_uc003ict.2_Missense_Mutation_p.K168I	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	545					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						CCAGGAGAGAAAATAACTGGC	0.418													6	56					0	0	0.001984	0	0
TNIP3	79931	broad.mit.edu	37	4	122068287	122068287	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:122068287G>A	uc010ing.2	-	7	848	c.652C>T	c.(652-654)CGA>TGA	p.R218*	TNIP3_uc010inh.2_Nonsense_Mutation_p.R218*|TNIP3_uc011cgj.1_Nonsense_Mutation_p.R276*	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	218	Potential.									ovary(1)	1						AGTCTCTCTCGATCCGATCGT	0.373													24	71					0	0	0.002780	0	0
ADAD1	132612	broad.mit.edu	37	4	123333892	123333892	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:123333892G>A	uc003ieo.2	+	10	1409	c.1177G>A	c.(1177-1179)GAA>AAA	p.E393K	ADAD1_uc003iep.2_Missense_Mutation_p.E382K|ADAD1_uc003ieq.2_Missense_Mutation_p.E375K	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	393	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						GACCAGATGGGAAGTGCTTGG	0.423													11	109					0	0	0.013537	0	0
FAT4	79633	broad.mit.edu	37	4	126336808	126336808	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:126336808G>A	uc003ifj.3	+	5	6690	c.6690G>A	c.(6688-6690)CAG>CAA	p.Q2230Q	FAT4_uc011cgp.1_Silent_p.Q528Q	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2230	Cadherin 21.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TAACTGTTCAGGCAACAGATC	0.443													5	74					0	0	0.001984	0	0
FAT4	79633	broad.mit.edu	37	4	126373926	126373926	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:126373926C>T	uc003ifj.3	+	9	11755	c.11755C>T	c.(11755-11757)CCA>TCA	p.P3919S	FAT4_uc011cgp.1_Missense_Mutation_p.P2217S|FAT4_uc003ifi.1_Missense_Mutation_p.P1397S	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3919	EGF-like 3; calcium-binding (Potential).|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCAGAATTTTCCAGGAAGCTT	0.448													9	58					0	0	0.010729	0	0
FAT4	79633	broad.mit.edu	37	4	126411233	126411233	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:126411233G>A	uc003ifj.3	+	17	13256	c.13256G>A	c.(13255-13257)TGG>TAG	p.W4419*	FAT4_uc011cgp.1_Nonsense_Mutation_p.W2660*|FAT4_uc003ifi.1_Nonsense_Mutation_p.W1896*	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4419	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ATTAATCAGTGGTATGCCTAC	0.577													33	88					0	0	0.010818	0	0
FAT4	79633	broad.mit.edu	37	4	126411537	126411537	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:126411537C>T	uc003ifj.3	+	17	13560	c.13560C>T	c.(13558-13560)GTC>GTT	p.V4520V	FAT4_uc011cgp.1_Silent_p.V2761V|FAT4_uc003ifi.1_Silent_p.V1997V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4520	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCCTCCTGGTCCTTAGCCTGA	0.542													8	30					0	0	0.006214	0	0
FAT4	79633	broad.mit.edu	37	4	126411707	126411707	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:126411707G>A	uc003ifj.3	+	17	13730	c.13730G>A	c.(13729-13731)GGG>GAG	p.G4577E	FAT4_uc011cgp.1_Missense_Mutation_p.G2818E|FAT4_uc003ifi.1_Missense_Mutation_p.G2054E	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4577	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CAGCCTGAAGGGAACCCAAAA	0.458													4	48					0	0	0.009096	0	0
SLC25A31	83447	broad.mit.edu	37	4	128688264	128688264	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:128688264G>A	uc003ifl.2	+	4	668	c.522G>A	c.(520-522)ATG>ATA	p.M174I		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	174	Solcar 2.				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						ACTGTATTATGAAAATAGCAA	0.358													15	44					0	0	0.002450	0	0
PLK4	10733	broad.mit.edu	37	4	128814691	128814691	+	Silent	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:128814691G>C	uc003ifo.2	+	12	2591	c.2346G>C	c.(2344-2346)CTG>CTC	p.L782L	PLK4_uc011cgs.1_Silent_p.L750L|PLK4_uc011cgt.1_Silent_p.L741L	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	782					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GTTTAGCACTGGAATCCATAA	0.338													4	51					0	0	0.001168	0	0
PCDH18	54510	broad.mit.edu	37	4	138451522	138451522	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:138451522G>A	uc003ihe.3	-	1	2108	c.1721C>T	c.(1720-1722)CCT>CTT	p.P574L	PCDH18_uc003ihf.3_Missense_Mutation_p.P567L|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.P354L|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	574	Extracellular (Potential).|Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TATAACCACAGGAACGTTGTC	0.453													14	121					0	0	0.004007	0	0
RNF150	57484	broad.mit.edu	37	4	141888920	141888920	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:141888920G>A	uc003iio.1	-	2	1246	c.592C>T	c.(592-594)CGG>TGG	p.R198W	RNF150_uc010iok.1_Missense_Mutation_p.R198W|RNF150_uc003iip.1_Missense_Mutation_p.R198W	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	198	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					TGCAAGTTCCGGGTTCCGATG	0.463													13	167					0	0	0.004990	0	0
OTUD4	54726	broad.mit.edu	37	4	146092826	146092826	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:146092826G>A	uc003ika.3	-	3	233	c.95C>T	c.(94-96)CCA>CTA	p.P32L	OTUD4_uc003ijz.3_Missense_Mutation_p.P32L|OTUD4_uc003ikb.3_Missense_Mutation_p.P32L	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	97	OTU.						protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					ACATACCTGTGGATTTTCCAA	0.244													4	46					0	0	0.000602	0	0
C4orf51	646603	broad.mit.edu	37	4	146651099	146651099	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:146651099G>A	uc003ikk.2	+	5	483	c.483G>A	c.(481-483)GGG>GGA	p.G161G		NM_001080531	NP_001074000	C9J302	CD051_HUMAN	chromosome 4 open reading frame 51	161											0						GTCGACGAGGGAAAGGTGTCC	0.483													7	61					0	0	0.001984	0	0
ZNF827	152485	broad.mit.edu	37	4	146806916	146806916	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:146806916G>A	uc003ikn.2	-	4	1709	c.1661C>T	c.(1660-1662)TCC>TTC	p.S554F	ZNF827_uc003ikm.2_Missense_Mutation_p.S554F|ZNF827_uc010iox.2_Missense_Mutation_p.S204F	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					CACATACTCGGAGGGGTCTTT	0.522													6	59					0	0	0.003080	0	0
EDNRA	1909	broad.mit.edu	37	4	148453722	148453722	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:148453722G>A	uc003iky.2	+	4	1305	c.613G>A	c.(613-615)GAA>AAA	p.E205K	EDNRA_uc011cid.1_5'UTR|EDNRA_uc010ipe.1_Silent_p.*162*|EDNRA_uc010ipf.1_Intron|EDNRA_uc010ipg.1_Intron	NM_001957	NP_001948	P25101	EDNRA_HUMAN	endothelin receptor type A isoform a precursor	205	Cytoplasmic (Potential).				activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|breast(1)	2	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	AACTGCCATTGAAATTGTCTC	0.453													17	98					0	0	0.004007	0	0
LRBA	987	broad.mit.edu	37	4	151223869	151223869	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:151223869C>T	uc010ipj.2	-	54	8432	c.7958G>A	c.(7957-7959)GGA>GAA	p.G2653E	LRBA_uc010ipi.2_Missense_Mutation_p.G175E|LRBA_uc003ils.3_Missense_Mutation_p.G548E|LRBA_uc003ilt.3_Missense_Mutation_p.G1301E|LRBA_uc003ilu.3_Missense_Mutation_p.G2642E|LRBA_uc003ilr.3_Missense_Mutation_p.G73E	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2653	WD 3.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					GTAGCAATTTCCCCCAATATA	0.428													5	41					0	0	0.000602	0	0
DCHS2	54798	broad.mit.edu	37	4	155157247	155157247	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:155157247G>A	uc003inw.2	-	25	7192	c.7192C>T	c.(7192-7194)CAA>TAA	p.Q2398*		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2398	Cadherin 21.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCTTTGGCTTGGACTGTGAGG	0.408													8	67					0	0	0.004482	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156711039	156711039	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:156711039C>T	uc003ipc.2	+	5	638	c.471C>T	c.(469-471)ATC>ATT	p.I157I	GUCY1B3_uc011cio.1_Silent_p.I179I|GUCY1B3_uc011cip.1_Silent_p.I137I|GUCY1B3_uc003ipd.2_Silent_p.I85I|GUCY1B3_uc010iqf.2_Silent_p.I157I|GUCY1B3_uc010iqg.2_Silent_p.I85I|GUCY1B3_uc011ciq.1_Silent_p.I85I	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	157					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		CACAACAAATCCATGGCACTG	0.373													18	72					0	0	0.008871	0	0
PDGFC	56034	broad.mit.edu	37	4	157771463	157771463	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:157771463C>T	uc003iph.1	-	2	715	c.224G>A	c.(223-225)TGG>TAG	p.W75*	PDGFC_uc003ipi.1_5'UTR|PDGFC_uc011cis.1_Intron|PDGFC_uc011cir.1_5'UTR	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	75	CUB.				central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		TACTAATCTCCATACCAAGAC	0.388													5	47					0	0	0.000602	0	0
TLL1	7092	broad.mit.edu	37	4	166946578	166946578	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:166946578G>A	uc003irh.1	+	9	1800	c.1153G>A	c.(1153-1155)GAG>AAG	p.E385K	TLL1_uc011cjn.1_Missense_Mutation_p.E385K|TLL1_uc011cjo.1_Missense_Mutation_p.E209K	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	385	CUB 1.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GACCCCAGGGGAGAAGGTAGT	0.388													5	44					0	0	0.000602	0	0
ANXA10	11199	broad.mit.edu	37	4	169105801	169105801	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:169105801G>A	uc003irm.2	+	11	1020	c.875G>A	c.(874-876)CGA>CAA	p.R292Q	ANXA10_uc003irn.2_Missense_Mutation_p.R164Q	NM_007193	NP_009124	Q9UJ72	ANX10_HUMAN	annexin A10	292	Annexin 4.						calcium ion binding|calcium-dependent phospholipid binding				0		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		TACAAAGAGCGATATGGAAAA	0.353													22	66					0	0	0.002780	0	0
DDX60L	91351	broad.mit.edu	37	4	169300899	169300899	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:169300899G>A	uc003irq.3	-	31	4420	c.4199C>T	c.(4198-4200)TCC>TTC	p.S1400F		NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1400							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		GAGCTGCAAGGAAAACAAAAA	0.368													11	23					0	0	0.008291	0	0
GALNTL6	442117	broad.mit.edu	37	4	173730543	173730544	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:173730543_173730544GG>AA	uc003isv.2	+	6	1321_1322	c.585_586GG>AA	c.(583-588)ATGGCC>ATAACC	p.195_196MA>IT		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	195_196	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						AAGAATACATGGCCCGATTTTC	0.455													16	46					0	0	0.004672	0	0
VEGFC	7424	broad.mit.edu	37	4	177608423	177608423	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:177608423G>A	uc003ius.1	-	6	1493	c.1063C>T	c.(1063-1065)CCT>TCT	p.P355S		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	355	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.|4.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		CATTTTCCAGGATTTAGGGGT	0.438													11	124					0	0	0.010729	0	0
ODZ3	55714	broad.mit.edu	37	4	183664394	183664394	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:183664394G>A	uc003ivd.1	+	18	3488	c.3451G>A	c.(3451-3453)GGC>AGC	p.G1151S	ODZ3_uc003ive.1_Missense_Mutation_p.G557S	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1151	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TAGCATCATGGGCAATGGGCG	0.507													13	21					0	0	0.002450	0	0
ODZ3	55714	broad.mit.edu	37	4	183675993	183675993	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:183675993G>A	uc003ivd.1	+	21	4510	c.4473G>A	c.(4471-4473)GGG>GGA	p.G1491G	ODZ3_uc003ive.1_Silent_p.G904G	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1491	Extracellular (Potential).|NHL 5.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CAGATCTAGGGAATATCCGGA	0.468													4	72					0	0	0.009096	0	0
PDLIM3	27295	broad.mit.edu	37	4	186435444	186435444	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:186435444G>A	uc003ixw.3	-	4	502	c.378C>T	c.(376-378)TTC>TTT	p.F126F	PDLIM3_uc003ixx.3_Intron|PDLIM3_uc010isi.2_Intron|PDLIM3_uc003ixy.2_Missense_Mutation_p.S189L|PDLIM3_uc003ixz.2_Missense_Mutation_p.S189L	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	126						sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		CCGGGATCACGAAAGGTTTGG	0.463													21	66					0	0	0.003330	0	0
TLR3	7098	broad.mit.edu	37	4	187004511	187004511	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:187004511C>T	uc003iyq.2	+	4	1772	c.1671C>T	c.(1669-1671)TTC>TTT	p.F557F	TLR3_uc011ckz.1_Silent_p.F280F|TLR3_uc003iyr.2_Silent_p.F280F	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	557	Lumenal (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		CCATTTATTTCCTAAAGGGTC	0.443													16	41					0	0	0.004007	0	0
FAT1	2195	broad.mit.edu	37	4	187521125	187521125	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:187521125G>A	uc003izf.2	-	22	12218	c.12030C>T	c.(12028-12030)TTC>TTT	p.F4010F	FAT1_uc003ize.2_5'Flank	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4010	Extracellular (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGGCCGTCAGGAAGCAGCCTG	0.532										HNSCC(5;0.00058)			6	58					0	0	0.001168	0	0
TRIML1	339976	broad.mit.edu	37	4	189061722	189061722	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:189061722G>A	uc003izm.1	+	2	564	c.449G>A	c.(448-450)AGA>AAA	p.R150K		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	150	Potential.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CGTGTAAGGAGAAAGGAAGCT	0.473													4	65					0	0	0.001168	0	0
TRIML1	339976	broad.mit.edu	37	4	189068052	189068052	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr4:189068052G>A	uc003izm.1	+	6	1048	c.933G>A	c.(931-933)GGG>GGA	p.G311G	TRIML1_uc003izn.1_Silent_p.G35G	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	311	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TGAAATATGGGGGAAGCAGAC	0.532													5	106					0	0	0.001984	0	0
SDHA	6389	broad.mit.edu	37	5	225537	225538	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:225537_225538GG>AA	uc003jao.3	+	4	431_432	c.316_317GG>AA	c.(316-318)GGA>AAA	p.G106K	SDHA_uc003jan.2_Missense_Mutation_p.G106K|SDHA_uc011clv.1_Missense_Mutation_p.G106K|SDHA_uc011clw.1_Intron|SDHA_uc003jap.3_Missense_Mutation_p.G106K|SDHA_uc003jaq.3_5'Flank	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	106	FAD (By similarity).				nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	TTTCCAGGGAGGAATCAATGCT	0.569									Familial_Paragangliomas				7	38					0	0	0.004672	0	0
AHRR	57491	broad.mit.edu	37	5	427983	427983	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:427983G>A	uc003jav.2	+	9	880	c.836G>A	c.(835-837)GGA>GAA	p.G279E	AHRR_uc003jaw.2_Missense_Mutation_p.G257E|AHRR_uc010isy.2_Missense_Mutation_p.G107E|AHRR_uc010isz.2_Missense_Mutation_p.G257E|AHRR_uc003jax.2_Missense_Mutation_p.G20E|AHRR_uc003jay.2_Missense_Mutation_p.G117E	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GCGCCGTCAGGAGCCATGCTC	0.557													4	24					0	0	0.009096	0	0
AHRR	57491	broad.mit.edu	37	5	427986	427986	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:427986C>T	uc003jav.2	+	9	883	c.839C>T	c.(838-840)GCC>GTC	p.A280V	AHRR_uc003jaw.2_Missense_Mutation_p.A258V|AHRR_uc010isy.2_Missense_Mutation_p.A108V|AHRR_uc010isz.2_Missense_Mutation_p.A258V|AHRR_uc003jax.2_Missense_Mutation_p.A21V|AHRR_uc003jay.2_Missense_Mutation_p.A118V	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			CCGTCAGGAGCCATGCTCCCG	0.552													4	24					0	0	0.009096	0	0
SLC6A18	348932	broad.mit.edu	37	5	1235756	1235756	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:1235756G>A	uc003jby.1	+	4	723	c.600G>A	c.(598-600)AGG>AGA	p.R200R		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	200	Helical; Name=4; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GTGTCATCAGGGGCATTGAGA	0.577													9	93					0	0	0.006214	0	0
TERT	7015	broad.mit.edu	37	5	1255502	1255502	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:1255502G>A	uc003jcb.1	-	14	3115	c.3057C>T	c.(3055-3057)CTC>CTT	p.L1019L	TERT_uc003jbz.1_Silent_p.L215L|TERT_uc003jca.1_Silent_p.L1007L|TERT_uc003jcc.1_Silent_p.L956L|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	1019	CTE.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GATGAAATGGGAGCTGCAGCA	0.483									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				8	25					0	0	0.006214	0	0
MTRR	4552	broad.mit.edu	37	5	7878144	7878144	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:7878144A>G	uc003jed.2	+	5	600	c.570A>G	c.(568-570)ATA>ATG	p.I190M	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.I163M|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	190					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	AAGAGGAGATAAGTGGCGCAC	0.507													3	22					0	0	0.004672	0	0
SEMA5A	9037	broad.mit.edu	37	5	9190535	9190535	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:9190535G>A	uc003jek.2	-	11	1829	c.1117C>T	c.(1117-1119)CTG>TTG	p.L373L		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	373	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GCATCCTGCAGATTTCTCTCG	0.577													5	24					0	0	0.001168	0	0
CTNND2	1501	broad.mit.edu	37	5	11159743	11159743	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:11159743G>A	uc003jfa.1	-	12	2249	c.2104C>T	c.(2104-2106)CGG>TGG	p.R702W	CTNND2_uc010itt.2_Missense_Mutation_p.R611W|CTNND2_uc011cmy.1_Missense_Mutation_p.R365W|CTNND2_uc011cmz.1_Missense_Mutation_p.R269W|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.R269W	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	702	ARM 5.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGTATTTTCCGATCATCCTGA	0.547													8	60					0	0	0.006214	0	0
CTNND2	1501	broad.mit.edu	37	5	11732304	11732304	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:11732304C>T	uc003jfa.1	-	2	263	c.118G>A	c.(118-120)GGG>AGG	p.G40R	CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	40					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GAGCCATCCCCGTTGGAGGTG	0.512													16	53					0	0	0.003163	0	0
DNAH5	1767	broad.mit.edu	37	5	13776782	13776782	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:13776782C>T	uc003jfd.2	-	55	9181	c.9139G>A	c.(9139-9141)GAA>AAA	p.E3047K		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3047	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTATTAATTTCATCAATTTCA	0.408									Kartagener_syndrome				13	43					0	0	0.001855	0	0
DNAH5	1767	broad.mit.edu	37	5	13923469	13923469	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:13923469C>T	uc003jfd.2	-	4	400	c.358G>A	c.(358-360)GAT>AAT	p.D120N	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	120	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGAGCCACATCGTTTCCCTCG	0.458									Kartagener_syndrome				18	84					0	0	0.004990	0	0
MARCH11	441061	broad.mit.edu	37	5	16177850	16177850	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:16177850C>T	uc003jfo.2	-	2	891	c.678G>A	c.(676-678)ATG>ATA	p.M226I	uc003jfp.2_5'Flank	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	226						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						AAGGTTGTTTCATTTTAATGG	0.353													12	37					0	0	0.002450	0	0
PRDM9	56979	broad.mit.edu	37	5	23526486	23526486	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:23526486C>T	uc003jgo.2	+	11	1471	c.1289C>T	c.(1288-1290)CCC>CTC	p.P430L		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	430					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CCAGAGAATCCCTGCCCAGGG	0.453										HNSCC(3;0.000094)			10	45					0	0	0.001855	0	0
PRDM9	56979	broad.mit.edu	37	5	23527702	23527702	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:23527702G>A	uc003jgo.2	+	11	2687	c.2505G>A	c.(2503-2505)AGG>AGA	p.R835R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	835	C2H2-type 13.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATGTCTGCAGGGAGTGTGGGC	0.597										HNSCC(3;0.000094)			10	55					0	0	0.006214	0	0
CDH6	1004	broad.mit.edu	37	5	31299680	31299680	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:31299680C>T	uc003jhe.1	+	5	1079	c.753C>T	c.(751-753)ACC>ACT	p.T251T	CDH6_uc003jhd.1_Silent_p.T251T	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	251	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TATCTGGGACCACCACCGTGA	0.478													6	71					0	0	0.001984	0	0
RNASEN	29102	broad.mit.edu	37	5	31401632	31401632	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:31401632G>A	uc003jhg.2	-	35	4391	c.4032C>T	c.(4030-4032)ATC>ATT	p.I1344I	RNASEN_uc003jhh.2_Silent_p.I1307I	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	1344	Necessary for interaction with DGCR8 and pri-miRNA processing activity.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						ACTTCCGTTCGATGAACCGCT	0.358													9	56					0	0	0.004482	0	0
PDZD2	23037	broad.mit.edu	37	5	32087283	32087283	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:32087283G>A	uc003jhl.2	+	20	4117	c.3729G>A	c.(3727-3729)GGG>GGA	p.G1243G	PDZD2_uc003jhm.2_Silent_p.G1243G	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1243					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GGAAGAAGGGGGCCGCTCATC	0.577													8	119					0	0	0.004482	0	0
PDZD2	23037	broad.mit.edu	37	5	32090662	32090662	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:32090662G>A	uc003jhl.2	+	20	7496	c.7108G>A	c.(7108-7110)GGG>AGG	p.G2370R	PDZD2_uc003jhm.2_Missense_Mutation_p.G2370R	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2370					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GCCTCCCATTGGGAGGCGGTC	0.592													15	14					0	0	0.002450	0	0
MTMR12	54545	broad.mit.edu	37	5	32248166	32248166	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:32248166G>A	uc003jhq.2	-	10	1133	c.963C>T	c.(961-963)TTC>TTT	p.F321F	MTMR12_uc010iuk.2_Silent_p.F321F|MTMR12_uc010iul.2_Silent_p.F321F	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	321	Myotubularin phosphatase.					cytoplasm	phosphatase activity			ovary(1)	1						GCAGGGACAGGAAGTTGCTTG	0.383													8	64					0	0	0.003080	0	0
ZFR	51663	broad.mit.edu	37	5	32387754	32387754	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:32387754G>A	uc003jhr.1	-	14	2480	c.2400C>T	c.(2398-2400)CTC>CTT	p.L800L	ZFR_uc011cny.1_RNA	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	800	DZF.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		TATCTCCTCGGAGAAGTAATC	0.383													8	61					0	0	0.006214	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33616044	33616044	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:33616044G>A	uc003jia.1	-	15	2440	c.2277C>T	c.(2275-2277)ATC>ATT	p.I759I	ADAMTS12_uc010iuq.1_Silent_p.I674I	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	759	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CGTTCCACTGGATAATAAACC	0.473										HNSCC(64;0.19)			5	63					0	0	0.000602	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33658334	33658334	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:33658334G>A	uc003jia.1	-	7	1308	c.1145C>T	c.(1144-1146)TCG>TTG	p.S382L	ADAMTS12_uc010iuq.1_Missense_Mutation_p.S382L	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	382	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGGGAGTCCCGAATCTTCATT	0.507										HNSCC(64;0.19)			17	78					0	0	0.004990	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33683134	33683134	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:33683134C>T	uc003jia.1	-	5	1067	c.904G>A	c.(904-906)GAA>AAA	p.E302K	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E302K	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	302	Poly-Glu.|Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCTTCTTCTTCGAGTAGAATG	0.423										HNSCC(64;0.19)			11	25					0	0	0.008291	0	0
SLC45A2	51151	broad.mit.edu	37	5	33947288	33947288	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:33947288G>A	uc003jid.2	-	6	1440	c.1348C>T	c.(1348-1350)CAC>TAC	p.H450Y	SLC45A2_uc003jie.2_Missense_Mutation_p.H450Y	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	450	Cytoplasmic (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TCCTCGCGGTGGTACTCAGTA	0.517													33	117					0	0	0.004289	0	0
PRLR	5618	broad.mit.edu	37	5	35072682	35072682	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:35072682A>C	uc003jjm.2	-	6	1068	c.538T>G	c.(538-540)TGG>GGG	p.W180G	PRLR_uc003jjg.1_Missense_Mutation_p.W180G|PRLR_uc003jjh.1_Missense_Mutation_p.W180G|PRLR_uc003jji.1_Missense_Mutation_p.W109G|PRLR_uc003jjj.1_Missense_Mutation_p.W180G|PRLR_uc003jjk.1_Missense_Mutation_p.W109G|PRLR_uc003jjl.3_Missense_Mutation_p.W79G|PRLR_uc010iuw.1_Missense_Mutation_p.W109G	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	180	Fibronectin type-III 2.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CTCACCTCCCACTCAGCTGCT	0.443													3	50					0	0	0.004672	0	0
UGT3A1	133688	broad.mit.edu	37	5	35957318	35957318	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:35957318C>T	uc003jjv.1	-	5	1204	c.1047G>A	c.(1045-1047)GTG>GTA	p.V349V	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Silent_p.V349V|UGT3A1_uc011cor.1_Silent_p.V315V	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	349	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAAGCCAGTCCACAATTTTCA	0.498													10	43					0	0	0.013537	0	0
C5orf42	65250	broad.mit.edu	37	5	37183083	37183083	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:37183083G>A	uc011cpa.1	-	26	5431	c.5200C>T	c.(5200-5202)CCT>TCT	p.P1734S	C5orf42_uc011coy.1_Missense_Mutation_p.P235S|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.P809S|C5orf42_uc011cpb.1_Missense_Mutation_p.P615S	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1734										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			AGTGCTAAAGGAAGATCTTCT	0.373													9	57					0	0	0.008291	0	0
EGFLAM	133584	broad.mit.edu	37	5	38463998	38463998	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:38463998C>T	uc003jlc.1	+	23	3288	c.2964C>T	c.(2962-2964)ATC>ATT	p.I988I	EGFLAM_uc003jlb.1_Silent_p.I980I|EGFLAM_uc003jle.1_Silent_p.I746I|EGFLAM_uc003jlf.1_Silent_p.I346I|EGFLAM_uc003jlg.1_Silent_p.I123I|EGFLAM_uc003jlh.1_Silent_p.I70I	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	988	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TGGGCTGTATCTCTCACTTCA	0.507													8	31					0	0	0.006214	0	0
LIFR	3977	broad.mit.edu	37	5	38496631	38496631	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:38496631C>T	uc010ive.1	-	13	2070	c.1738G>A	c.(1738-1740)GAA>AAA	p.E580K	LIFR_uc003jli.2_Missense_Mutation_p.E580K	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	580	Extracellular (Potential).|Fibronectin type-III 4.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					GACTGTGTTTCCTCATCTGAT	0.373			T	PLAG1	salivary adenoma								10	38					0	0	0.010729	0	0
OSMR	9180	broad.mit.edu	37	5	38884075	38884075	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:38884075G>A	uc003jln.1	+	5	932	c.565G>A	c.(565-567)GAA>AAA	p.E189K	OSMR_uc003jlm.1_Missense_Mutation_p.E189K	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	189	Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					GATTCATGGAGAACAACTTGA	0.368													6	67					0	0	0.001984	0	0
OSMR	9180	broad.mit.edu	37	5	38925388	38925388	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:38925388C>T	uc003jln.1	+	15	2494	c.2127C>T	c.(2125-2127)TTC>TTT	p.F709F	OSMR_uc011cpj.1_5'UTR	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	709	Fibronectin type-III 4.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					CAGAATCCTTCTATGAGTTTT	0.428													8	74					0	0	0.008291	0	0
PRKAA1	5562	broad.mit.edu	37	5	40764857	40764857	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:40764857C>T	uc003jmc.2	-	7	1311	c.1305G>A	c.(1303-1305)TGG>TGA	p.W435*	PRKAA1_uc003jmb.2_Nonsense_Mutation_p.W450*	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	435					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	TTCTTACCTTCCATTCATAAT	0.294													6	21					0	0	0.001168	0	0
CARD6	84674	broad.mit.edu	37	5	40841643	40841643	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:40841643C>T	uc003jmg.2	+	1	234	c.159C>T	c.(157-159)CTC>CTT	p.L53L		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	53	CARD.				apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						TTACAGATCTCCTGAAGAAAA	0.403													4	27					0	0	0.009096	0	0
CARD6	84674	broad.mit.edu	37	5	40853853	40853853	+	Missense_Mutation	SNP	C	T	T	rs34452222		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:40853853C>T	uc003jmg.2	+	3	2494	c.2419C>T	c.(2419-2421)CGG>TGG	p.R807W		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	807					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						CAGAGTTGCTCGGGGATGTCA	0.473													17	248					0	0	0.010504	0	0
C6	729	broad.mit.edu	37	5	41176728	41176728	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:41176728C>T	uc003jmk.2	-	8	1227	c.1017G>A	c.(1015-1017)TTG>TTA	p.L339L	C6_uc003jml.1_Silent_p.L339L	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	339	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TAAGTGCTTTCAAAAAGACAT	0.398													7	42					0	0	0.004482	0	0
C6	729	broad.mit.edu	37	5	41203264	41203264	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:41203264G>A	uc003jmk.2	-	2	279	c.69C>T	c.(67-69)TTC>TTT	p.F23F	C6_uc003jml.1_Silent_p.F23F	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	23	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AGTGATCACAGAAGCAGGCTT	0.507													9	87					0	0	0.004482	0	0
MGC42105	167359	broad.mit.edu	37	5	43246149	43246149	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:43246149G>A	uc003jno.2	+	2	1153	c.272G>A	c.(271-273)GGG>GAG	p.G91E		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	91	Protein kinase.						ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						GTGAAGCTTGGGATTCACTCC	0.537													6	32					0	0	0.003080	0	0
HCN1	348980	broad.mit.edu	37	5	45645578	45645578	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:45645578G>A	uc003jok.2	-	2	583	c.558C>T	c.(556-558)TTC>TTT	p.F186F		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	186	Helical; Name=Segment S2; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GGTCCAATAGGAAAACTGTAT	0.368													17	54					0	0	0.007413	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54649091	54649092	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:54649091_54649092CC>TT	uc003jpy.3	+	14	1793_1794	c.1527_1528CC>TT	c.(1525-1530)TTCCGA>TTTTGA	p.R510*	SKIV2L2_uc011cqi.1_Nonsense_Mutation_p.R409*	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	510	Helicase C-terminal.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				GGAAGGATTTCCGATGGGTAAG	0.356													6	49					0	0	0.004672	0	0
PLK2	10769	broad.mit.edu	37	5	57755646	57755646	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:57755646G>A	uc003jrn.2	-	1	268	c.141C>T	c.(139-141)TCC>TCT	p.S47S	PLK2_uc011cql.1_5'Flank	NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	47					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		CTTGCGCCTGGGACTGAGGTG	0.677													4	33					0	0	0.001168	0	0
IPO11	51194	broad.mit.edu	37	5	61802166	61802166	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:61802166C>T	uc003jtc.2	+	19	1954	c.1764C>T	c.(1762-1764)ATC>ATT	p.I588I	IPO11_uc011cqr.1_Silent_p.I628I|IPO11_uc003jtd.1_RNA	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	588	HEAT 7.					cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		CTTGTGTGATCGAAAGAGTCA	0.348													5	32					0	0	0.000602	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64748012	64748012	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:64748012C>T	uc003jtp.2	-	6	1689	c.875G>A	c.(874-876)GGA>GAA	p.G292E	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_5'UTR	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	292	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CACAACGTTTCCTAGGCTGGA	0.353													6	35					0	0	0.006214	0	0
NAIP	4671	broad.mit.edu	37	5	70308397	70308397	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:70308397C>T	uc003kar.1	-	4	1064	c.346G>A	c.(346-348)GAC>AAC	p.D116N	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Missense_Mutation_p.D116N|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein isoform	116	BIR 1.				anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CTCTTGTGGTCTTCTATGGGG	0.488													5	77					0	0	0.001168	0	0
ENC1	8507	broad.mit.edu	37	5	73931021	73931021	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:73931021G>A	uc003kdc.3	-	2	2421	c.1290C>T	c.(1288-1290)CTC>CTT	p.L430L	ENC1_uc011css.1_Silent_p.L357L	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	430	Kelch 3.			LREGVSNAA -> RPRRRYNCAQ (in Ref. 1).	nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		CGCCTTCTCGGAGTGGGGCCA	0.537													13	44					0	0	0.001855	0	0
ENC1	8507	broad.mit.edu	37	5	73931360	73931360	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:73931360G>A	uc003kdc.3	-	2	2082	c.951C>T	c.(949-951)GCC>GCT	p.A317A	ENC1_uc011css.1_Silent_p.A244A	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	317	Kelch 1.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		TGATTTCTTTGGCCTTCTGGT	0.527													21	52					0	0	0.012319	0	0
LOC441089	441089	broad.mit.edu	37	5	79647056	79647056	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:79647056C>T	uc010jaj.1	-	1		c.730G>A				NR_003665				Homo sapiens CRSP8 pseudogene (LOC441089), non-coding RNA.												0						CTGTCACCTTCTGGAATACTT	0.463													9	16					0	0	0.006214	0	0
RASGRF2	5924	broad.mit.edu	37	5	80409618	80409618	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:80409618G>A	uc003kha.1	+	15	2349	c.2349G>A	c.(2347-2349)CAG>CAA	p.Q783Q	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	783					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		ACACTGGTCAGATACCACTGG	0.552													4	22					0	0	0.009096	0	0
GPR98	84059	broad.mit.edu	37	5	89924621	89924621	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:89924621G>A	uc003kju.2	+	8	1577	c.1481G>A	c.(1480-1482)GGA>GAA	p.G494E	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	494	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACAATACGAGGAGGTGCAGAA	0.428													7	16					0	0	0.003080	0	0
GPR98	84059	broad.mit.edu	37	5	90040908	90040908	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:90040908G>A	uc003kju.2	+	51	10691	c.10595G>A	c.(10594-10596)TGG>TAG	p.W3532*	GPR98_uc003kjt.2_Nonsense_Mutation_p.W1238*|GPR98_uc003kjv.2_Nonsense_Mutation_p.W1132*	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3532	EAR 6.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTTACTGCTGGAATTCGGAG	0.398													27	230					0	0	0.012213	0	0
NR2F1	7025	broad.mit.edu	37	5	92929319	92929319	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:92929319C>T	uc003kkj.2	+	3	2730	c.1043C>T	c.(1042-1044)TCG>TTG	p.S348L		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	348					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		CAGGAGAAGTCGCAGTGCGCA	0.647													9	47					0	0	0.006214	0	0
PCSK1	5122	broad.mit.edu	37	5	95746664	95746664	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:95746664G>A	uc003kls.1	-	8	1115	c.909C>T	c.(907-909)TTC>TTT	p.F303F	PCSK1_uc010jbi.1_Intron	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	303	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAGCCCAGACGAAGATGGACC	0.498													9	69					0	0	0.004482	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100147811	100147811	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:100147811G>A	uc003knk.2	-	5	1148	c.820C>T	c.(820-822)CCT>TCT	p.P274S		NM_005668	NP_005659	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide	274	Lumenal (Potential).				axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			large_intestine(1)|central_nervous_system(1)	2		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		CTTTTGATAGGAACTTTGTTG	0.378													4	47					0	0	0.000602	0	0
NUDT12	83594	broad.mit.edu	37	5	102894904	102894904	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:102894904G>A	uc003koi.2	-	3	565	c.472C>T	c.(472-474)CCC>TCC	p.P158S	NUDT12_uc011cvb.1_Missense_Mutation_p.P140S	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	158						nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		GTAACCAAGGGATTTAAATCT	0.403													4	40					0	0	0.009096	0	0
TRIM36	55521	broad.mit.edu	37	5	114482954	114482954	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:114482954G>A	uc003kqs.2	-	3	945	c.436C>T	c.(436-438)CGT>TGT	p.R146C	TRIM36_uc011cwc.1_Missense_Mutation_p.R134C|TRIM36_uc003kqt.2_5'UTR	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	146						acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		GCTGCTTGACGATATCTTTCC	0.458													22	81					0	0	0.014323	0	0
SNCAIP	9627	broad.mit.edu	37	5	121739511	121739511	+	Silent	SNP	G	A	A	rs149915358	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:121739511G>A	uc003ksw.1	+	3	287	c.81G>A	c.(79-81)ACG>ACA	p.T27T	SNCAIP_uc011cwl.1_5'UTR|SNCAIP_uc010jct.2_Silent_p.T27T|SNCAIP_uc003ksx.1_Silent_p.T74T|SNCAIP_uc003ksy.1_Missense_Mutation_p.R12Q|SNCAIP_uc003ksz.1_Missense_Mutation_p.R12Q|SNCAIP_uc010jcu.2_Missense_Mutation_p.R12Q|SNCAIP_uc011cwm.1_Missense_Mutation_p.R12Q|SNCAIP_uc003kta.1_Missense_Mutation_p.R10Q|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.R12Q|SNCAIP_uc010jcx.1_Silent_p.T27T	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	27					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CACTCAAGACGATCCCAGAAC	0.453													26	68					0	0	0.006320	0	0
FBN2	2201	broad.mit.edu	37	5	127674658	127674658	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:127674658C>T	uc003kuu.2	-	26	3878	c.3439G>A	c.(3439-3441)GAA>AAA	p.E1147K	FBN2_uc003kuv.2_Missense_Mutation_p.E1114K	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1147	EGF-like 16; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AAGCCACTTTCATAGCCTTCG	0.507													6	36					0	0	0.001168	0	0
FBN2	2201	broad.mit.edu	37	5	127728828	127728828	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:127728828T>G	uc003kuu.2	-	10	1904	c.1465A>C	c.(1465-1467)ACA>CCA	p.T489P	FBN2_uc003kuv.2_Missense_Mutation_p.T456P	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	489					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GACCACTTACTTAGTCCAGTG	0.478													8	55					0	0	0.008291	0	0
SLC27A6	28965	broad.mit.edu	37	5	128351617	128351617	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:128351617G>A	uc003kuy.2	+	6	1405	c.1009G>A	c.(1009-1011)GGA>AGA	p.G337R	SLC27A6_uc003kuz.2_Missense_Mutation_p.G337R	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	337					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TTTGGCAATTGGAAATGGCAT	0.333													13	32					0	0	0.004007	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128984509	128984509	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:128984509G>A	uc003kvb.1	+	13	2004	c.2004G>A	c.(2002-2004)AGG>AGA	p.R668R	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	668	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CTGAAGCAAGGGATTGTAATG	0.343													5	44					0	0	0.000602	0	0
SHROOM1	134549	broad.mit.edu	37	5	132160479	132160479	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:132160479G>A	uc003kxx.2	-	6	1874	c.1069C>T	c.(1069-1071)CCT>TCT	p.P357S	SHROOM1_uc003kxy.1_Missense_Mutation_p.P357S	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	357					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AACTCTGCAGGATACATCACC	0.567													8	30					0	0	0.003080	0	0
DDX46	9879	broad.mit.edu	37	5	134147456	134147456	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:134147456C>T	uc003kzw.2	+	18	2525	c.2357C>T	c.(2356-2358)GCT>GTT	p.A786V	DDX46_uc003kzv.1_RNA	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	786					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACAGAACAAGCTTTGGCTAAT	0.363													11	51					0	0	0.008291	0	0
FBXL21	26223	broad.mit.edu	37	5	135277292	135277292	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:135277292G>A	uc010jec.1	+	5	1258	c.1237G>A	c.(1237-1239)GAA>AAA	p.E413K	FBXL21_uc003lbc.2_Intron	NM_012159	NP_036291	Q9UKT6	FXL21_HUMAN	F-box and leucine-rich repeat protein 21	413					rhythmic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TAGCCTAGATGAAATTCACAC	0.433													4	24					0	0	0.000602	0	0
TRPC7	57113	broad.mit.edu	37	5	135692539	135692539	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:135692539G>A	uc003lbn.1	-	1	537	c.534C>T	c.(532-534)ATC>ATT	p.I178I	TRPC7_uc010jef.1_Silent_p.I170I|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Silent_p.I170I|TRPC7_uc010jei.1_Silent_p.I170I|TRPC7_uc010jej.1_5'UTR	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	179	Cytoplasmic (Potential).|ANK 4.				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGATGTGCACGATCTCATACT	0.607													6	100					0	0	0.004482	0	0
EGR1	1958	broad.mit.edu	37	5	137803494	137803494	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:137803494C>T	uc003ldb.1	+	2	1626	c.1356C>T	c.(1354-1356)TCC>TCT	p.S452S	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	452					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			cttacccgtccccggttacta	0.129													3	10					0	0	0.004672	0	0
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139889306	139889306	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:139889306A>C	uc003lfs.1	+	21	3974	c.3850A>C	c.(3850-3852)AAT>CAT	p.N1284H	ANKHD1_uc003lfq.1_Missense_Mutation_p.N1303H|ANKHD1_uc003lfr.2_Missense_Mutation_p.N1284H|ANKHD1_uc003lft.1_Missense_Mutation_p.N495H|ANKHD1_uc003lfu.1_Missense_Mutation_p.N764H|ANKHD1_uc003lfv.1_Missense_Mutation_p.N361H|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.N23H|ANKHD1_uc003lfw.2_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1284						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAGATGTTAATGCTCCCCC	0.438													13	23					0	0	0.002450	0	0
PCDHA1	56147	broad.mit.edu	37	5	140165987	140165987	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140165987G>A	uc003lhb.2	+	1	112	c.112G>A	c.(112-114)GAA>AAA	p.E38K	PCDHA1_uc003lha.2_Missense_Mutation_p.E38K|PCDHA1_uc003lgz.2_Missense_Mutation_p.E38K	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	38	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATCCCGGAGGAAGCCAAACA	0.657													4	49					0	0	0.009096	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166152	140166152	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140166152G>A	uc003lhb.2	+	1	277	c.277G>A	c.(277-279)GAG>AAG	p.E93K	PCDHA1_uc003lha.2_Missense_Mutation_p.E93K|PCDHA1_uc003lgz.2_Missense_Mutation_p.E93K	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	93	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATCGATCGCGAGGAGCTGTG	0.562													7	53					0	0	0.004482	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175879	140175879	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140175879G>A	uc003lhd.2	+	1	1436	c.1330G>A	c.(1330-1332)GAG>AAG	p.E444K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.E444K|PCDHA2_uc011czy.1_Missense_Mutation_p.E444K	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	444	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGTCCATCGAGGTGGCCGA	0.652													12	49					0	0	0.013537	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175944	140175945	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140175944_140175945GG>AA	uc003lhd.2	+	1	1501_1502	c.1395_1396GG>AA	c.(1393-1398)AAGGAG>AAAAAG	p.E466K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.E466K|PCDHA2_uc011czy.1_Missense_Mutation_p.E466K	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	466	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATTCGTGAAGGAGAACAACCC	0.649													4	48					0	0	0.004672	0	0
PCDHA6	56142	broad.mit.edu	37	5	140207725	140207726	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140207725_140207726CC>TT	uc003lho.2	+	1	76_77	c.49_50CC>TT	c.(49-51)CCG>TTG	p.P17L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.P17L|PCDHA6_uc011dab.1_Missense_Mutation_p.P17L	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	17					homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGCTCCTCCCGCTTCTGCTC	0.55													8	76					0	0	0.004672	0	0
PCDHA6	56142	broad.mit.edu	37	5	140207946	140207946	+	Silent	SNP	C	T	T	rs140846988	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140207946C>T	uc003lho.2	+	1	297	c.270C>T	c.(268-270)ATC>ATT	p.I90I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.I90I|PCDHA6_uc011dab.1_Silent_p.I90I	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	90	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATCGACCGCGAGG	0.602													23	146					0	0	0.006320	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214426	140214426	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140214426C>T	uc003lhq.2	+	1	458	c.458C>T	c.(457-459)CCA>CTA	p.P153L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.P153L	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	153	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTCGGTTTCCACTAGAGGGC	0.557													5	30					0	0	0.004482	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215316	140215316	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140215316G>A	uc003lhq.2	+	1	1348	c.1348G>A	c.(1348-1350)GAC>AAC	p.D450N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.D450N	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	450	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACGTGAACGACAACGCCCC	0.667													8	50					0	0	0.003080	0	0
PCDHA11	56138	broad.mit.edu	37	5	140248978	140248978	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140248978G>A	uc003lia.2	+	1	1148	c.290G>A	c.(289-291)GGG>GAG	p.G97E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.G97E	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	97	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTGTGCGGGCAGAGCGCG	0.562													21	172					0	0	0.010504	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255890	140255890	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140255890C>T	uc003lic.2	+	1	960	c.833C>T	c.(832-834)TCC>TTC	p.S278F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.S278F	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	278	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGAAATTTCCTATGGGATC	0.368													6	88					0	0	0.003080	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433423	140433423	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140433423G>A	uc003lik.1	+	1	2445	c.2368G>A	c.(2368-2370)GAG>AAG	p.E790K		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	790	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GATAAAAATGGAGGCTGGCTC	0.453													25	69					0	0	0.003954	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474611	140474611	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140474611C>T	uc003lil.2	+	1	375	c.237C>T	c.(235-237)TTC>TTT	p.F79F	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	79	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATTTGCAGTTCGATAGGCAGA	0.507													18	62					0	0	0.010504	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474698	140474698	+	Silent	SNP	C	T	T	rs11956826		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140474698C>T	uc003lil.2	+	1	462	c.324C>T	c.(322-324)TTC>TTT	p.F108F	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	108	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTACCTTTCCAGGTGTTAC	0.473													7	40					0	0	0.001984	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503681	140503681	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140503681C>T	uc003lip.1	+	1	2101	c.2101C>T	c.(2101-2103)CTC>TTC	p.L701F		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	701	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTCGCTCTTCCTCTTCTCGGT	0.711													14	125					0	0	0.003163	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516679	140516679	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140516679G>A	uc003liq.2	+	1	1880	c.1663G>A	c.(1663-1665)GAC>AAC	p.D555N		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	555	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACGCCAACGACAACTCGCC	0.716													10	36					0	0	0.010729	0	0
PCDHB6	56130	broad.mit.edu	37	5	140532188	140532188	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140532188A>C	uc003lir.2	+	1	2350	c.2350A>C	c.(2350-2352)ACC>CCC	p.T784P	PCDHB6_uc011dah.1_Missense_Mutation_p.T648P	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	784	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.T784T(1)		skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATGGAAGAAACCCCCACCTC	0.438													3	28					0	0	0.009096	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553474	140553474	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140553474C>G	uc003lit.2	+	1	1232	c.1058C>G	c.(1057-1059)ACT>AGT	p.T353S		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	353	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTTCACTTACTAGCCCAATT	0.488													3	15					0	0	0.004672	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554534	140554534	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140554534C>T	uc003lit.2	+	1	2292	c.2118C>T	c.(2116-2118)TTC>TTT	p.F706F	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	706	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTCCTGTTCGTGGCGGTGC	0.692													18	214					0	0	0.012319	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554647	140554647	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140554647C>T	uc003lit.2	+	1	2405	c.2231C>T	c.(2230-2232)TCC>TTC	p.S744F	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	744	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGACCCTATCCCAGAGCTAC	0.607													10	129					0	0	0.010729	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558555	140558555	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140558555C>T	uc011dai.1	+	1	1126	c.940C>T	c.(940-942)CAG>TAG	p.Q314*	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	314	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGAAAAATTTCAGTCCTATGA	0.398													10	149					0	0	0.006214	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558804	140558804	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140558804T>G	uc011dai.1	+	1	1375	c.1189T>G	c.(1189-1191)TCT>GCT	p.S397A	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	397	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGAAATCTTCTGTGGGGAA	0.458													9	88					0	0	0.004482	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558863	140558863	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140558863C>T	uc011dai.1	+	1	1434	c.1248C>T	c.(1246-1248)GCC>GCT	p.A416A	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	416	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAGCAGAGCCGAGTACAACG	0.507													8	79					0	0	0.003080	0	0
PCDHB18	54660	broad.mit.edu	37	5	140616324	140616324	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140616324C>T	uc003ljc.1	+	1	2387	c.2039C>T	c.(2038-2040)CCA>CTA	p.P680L		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						TGTCCCTTTCCAGGGCATCTG	0.627													23	52					0	0	0.014323	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710787	140710787	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140710787C>T	uc003lji.1	+	1	536	c.536C>T	c.(535-537)TCC>TTC	p.S179F	PCDHGA1_uc011dan.1_Missense_Mutation_p.S179F	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	179	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCATTTCTCCCTGGATGTG	0.527													8	56					0	0	0.004482	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720191	140720191	+	Silent	SNP	C	T	T	rs139317352		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140720191C>T	uc003ljk.1	+	1	1838	c.1653C>T	c.(1651-1653)TTC>TTT	p.F551F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.F551F	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	551	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAAGCCTGTTCGTGCTGGACC	0.602													22	73					0	0	0.003330	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725214	140725214	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140725214G>A	uc003ljm.1	+	1	1614	c.1614G>A	c.(1612-1614)GGG>GGA	p.G538G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Silent_p.G298G|PCDHGA3_uc011dap.1_Silent_p.G538G	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	538	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGACAGCGGGAACCCTCCAC	0.567													18	81					0	0	0.008871	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731997	140731997	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140731997C>T	uc003ljo.1	+	1	2170	c.2170C>T	c.(2170-2172)CAA>TAA	p.Q724*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA4_uc003ljq.1_5'Flank|PCDHGB1_uc011daq.1_Nonsense_Mutation_p.Q724*|PCDHGA4_uc003ljp.1_5'Flank	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	724	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCTGCTTTCAAACCGGTCT	0.582													17	51					0	0	0.008871	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755443	140755443	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140755443C>T	uc003ljy.1	+	1	1793	c.1793C>T	c.(1792-1794)TCG>TTG	p.S598L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.S598L	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	598	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAGAGACTCGGGCCAGAAC	0.711													14	43					0	0	0.001855	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140778252	140778252	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:140778252G>A	uc003lkf.1	+	1	558	c.558G>A	c.(556-558)CAG>CAA	p.Q186Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.Q186Q	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	186	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAGAAACAGGATGGTAGTA	0.423													7	53					0	0	0.004482	0	0
KCTD16	57528	broad.mit.edu	37	5	143853417	143853417	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:143853417G>A	uc003lnm.1	+	4	1656	c.1027G>A	c.(1027-1029)GAC>AAC	p.D343N	KCTD16_uc003lnn.1_Missense_Mutation_p.D343N	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	343						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			CCAGACTCTGGACCGTCCCAT	0.592													5	34					0	0	0.001168	0	0
SH3RF2	153769	broad.mit.edu	37	5	145393604	145393604	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:145393604C>T	uc003lnt.2	+	5	1277	c.1039C>T	c.(1039-1041)CCT>TCT	p.P347S	SH3RF2_uc011dbl.1_Missense_Mutation_p.P347S	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	347							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCAGACGTTCCTTCCAGCTG	0.527													8	56					0	0	0.004482	0	0
PLAC8L1	153770	broad.mit.edu	37	5	145464086	145464086	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:145464086G>A	uc003lnv.2	-	4	515	c.443C>T	c.(442-444)TCC>TTC	p.S148F	PLAC8L1_uc011dbp.1_RNA	NM_001029869	NP_001025040	A1L4L8	PL8L1_HUMAN	PLAC8-like 1	148											0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGGCAGATGGAAAAAGCCCA	0.517													5	50					0	0	0.000602	0	0
SPINK13	153218	broad.mit.edu	37	5	147665576	147665576	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:147665576C>T	uc003lpc.2	+	5	312	c.250C>T	c.(250-252)CGT>TGT	p.R84C	uc003lpb.1_Intron|SPINK13_uc010jgt.2_RNA	NM_001040129	NP_001035218	Q1W4C9	ISK13_HUMAN	serine PI Kazal type 5-like 3 precursor	84	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity				0						ATTTCATTATCGTATAAAATT	0.269													5	44					0	0	0.000602	0	0
PDE6A	5145	broad.mit.edu	37	5	149276290	149276290	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:149276290T>G	uc003lrg.3	-	11	1577	c.1457A>C	c.(1456-1458)GAG>GCG	p.E486A		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	486					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CTCAGCCAGCTCCTCTTCCTC	0.532													15	107					0	0	0.004007	0	0
CSF1R	1436	broad.mit.edu	37	5	149457738	149457738	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:149457738G>A	uc003lrl.2	-	4	861	c.666C>T	c.(664-666)ATC>ATT	p.I222I	CSF1R_uc011dcd.1_Silent_p.I74I|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Silent_p.I222I|CSF1R_uc011dce.1_Silent_p.I222I|CSF1R_uc011dcf.1_Silent_p.I222I	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	222	Extracellular (Potential).|Ig-like C2-type 3.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CTGAGCACACGATCTGGGCAG	0.582													8	52					0	0	0.004482	0	0
CCDC69	26112	broad.mit.edu	37	5	150578573	150578573	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:150578573C>T	uc003ltq.2	-	4	427	c.304G>A	c.(304-306)GAA>AAA	p.E102K	CCDC69_uc010jhu.2_5'UTR|CCDC69_uc011dcq.1_RNA	NM_015621	NP_056436	A6NI79	CCD69_HUMAN	coiled-coil domain containing 69	102	Potential.									ovary(2)	2		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGGCCTCTTCATTCTTTCCT	0.597													9	59					0	0	0.006214	0	0
C5orf40	408263	broad.mit.edu	37	5	156770011	156770011	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:156770011G>A	uc003lwu.2	-	2	722	c.534C>T	c.(532-534)CTC>CTT	p.L178L	CYFIP2_uc003lwq.2_Intron|CYFIP2_uc011ddn.1_Intron|CYFIP2_uc011ddo.1_Intron|CYFIP2_uc003lwr.2_Intron|CYFIP2_uc003lws.2_Intron|CYFIP2_uc003lwt.2_Intron|CYFIP2_uc011ddp.1_Intron	NM_001001343	NP_001001343	Q8TBE3	FNDC9_HUMAN	hypothetical protein LOC408263	178						integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCACCAGGGGGAGCCCCTGCA	0.622											OREG0016977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	79					0	0	0.006214	0	0
ATP10B	23120	broad.mit.edu	37	5	160047949	160047949	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:160047949G>A	uc003lym.1	-	15	2668	c.1821C>T	c.(1819-1821)ATC>ATT	p.I607I	ATP10B_uc010jit.1_5'UTR|ATP10B_uc003lyn.2_Silent_p.I165I	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	607	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGAGGGTTTGATGGTGACCT	0.448													36	135					0	0	0.006230	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171773190	171773190	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:171773190G>A	uc003mbr.2	-	12	1309	c.1138C>T	c.(1138-1140)CAG>TAG	p.Q380*		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	380	SH3 3.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATGGTTGTCTGGAATTCGGCG	0.577													27	77					0	0	0.008361	0	0
FAM153B	202134	broad.mit.edu	37	5	175528581	175528581	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:175528581G>A	uc003mdk.2	+	12	718	c.661G>A	c.(661-663)GAA>AAA	p.E221K		NM_001079529	NP_001072997	P0C7A2	F153B_HUMAN	hypothetical protein LOC202134	221										ovary(1)	1	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		CACACTGGCCGAACGTACGTA	0.463													11	59					0	0	0.002450	0	0
C5orf25	375484	broad.mit.edu	37	5	175740750	175740750	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:175740750A>T	uc003mds.3	+	7	2141	c.1734A>T	c.(1732-1734)GAA>GAT	p.E578D	C5orf25_uc003mdt.3_Missense_Mutation_p.E163D|C5orf25_uc003mdr.3_RNA|C5orf25_uc003mdv.2_Missense_Mutation_p.E39D			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	578											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		AGACCCTAGAAGATGACTTTC	0.507													22	139					0	0	0.014323	0	0
C5orf25	375484	broad.mit.edu	37	5	175763726	175763726	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:175763726A>T	uc003mds.3	+	10	2525	c.2118A>T	c.(2116-2118)GAA>GAT	p.E706D	C5orf25_uc003mdt.3_Missense_Mutation_p.E291D|C5orf25_uc003mdr.3_RNA|C5orf25_uc003mdv.2_Missense_Mutation_p.E167D			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	706											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		CACACAGAGAAATGTTCTTTA	0.448													7	98					0	0	0.004482	0	0
KIAA1191	57179	broad.mit.edu	37	5	175774688	175774689	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:175774688_175774689GG>AA	uc003mdw.2	-	9	1204_1205	c.832_833CC>TT	c.(832-834)CCA>TTA	p.P278L	KIAA1191_uc003mdx.2_Missense_Mutation_p.P259L|KIAA1191_uc003mdy.2_Missense_Mutation_p.P278L|KIAA1191_uc003mea.2_Missense_Mutation_p.P71L|KIAA1191_uc003mdz.2_RNA	NM_020444	NP_065177	Q96A73	K1191_HUMAN	hypothetical protein LOC57179 isoform a	278							protein binding			ovary(1)	1	all_cancers(89;0.00575)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.101)		TTCCATCACTGGGATGTCCATC	0.574													12	86					0	0	0.004672	0	0
FAF2	23197	broad.mit.edu	37	5	175921237	175921237	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:175921237T>A	uc003mej.3	+	7	675	c.622T>A	c.(622-624)TTC>ATC	p.F208I		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	208					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						TAGGATGCTCTTCTGGGCATG	0.398													5	49					0	0	0.003080	0	0
GPRIN1	114787	broad.mit.edu	37	5	176024766	176024766	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:176024766G>A	uc003meo.1	-	2	2245	c.2070C>T	c.(2068-2070)TCC>TCT	p.S690S		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	690						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTTTCCCCAGGGACACAGGCT	0.577													6	28					0	0	0.001984	0	0
DBN1	1627	broad.mit.edu	37	5	176894001	176894001	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:176894001G>A	uc003mgy.2	-	7	790	c.618C>T	c.(616-618)TTC>TTT	p.F206F	DBN1_uc003mgx.2_Silent_p.F208F|DBN1_uc010jkn.1_Silent_p.F156F|DBN1_uc003mgz.1_Silent_p.F143F	NM_004395	NP_004386	Q16643	DREB_HUMAN	drebrin 1 isoform a	206					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTCCTGCTCGAACCTGAGCC	0.667													10	35					0	0	0.008291	0	0
ZNF354B	117608	broad.mit.edu	37	5	178310847	178310847	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:178310847C>T	uc003mjl.2	+	5	1620	c.1394C>T	c.(1393-1395)CCA>CTA	p.P465L	ZNF354B_uc003mjm.2_Missense_Mutation_p.P465L	NM_058230	NP_478137	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGAGAAAAACCATGTAAATGT	0.373													8	39					0	0	0.006214	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178541047	178541047	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:178541047C>T	uc003mjw.2	-	22	3457	c.3457G>A	c.(3457-3459)GAG>AAG	p.E1153K	uc003mjv.3_5'Flank	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1153					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GGGTGATCCTCTGTGGCATTG	0.587													10	92					0	0	0.006214	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179302075	179302075	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:179302075G>A	uc003mlh.2	-	12	2050	c.2013C>T	c.(2011-2013)TTC>TTT	p.F671F	TBC1D9B_uc003mli.2_Silent_p.F671F|TBC1D9B_uc003mlj.2_Silent_p.F671F|TBC1D9B_uc011dgv.1_5'Flank	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	671	Helical; (Potential).|Rab-GAP TBC.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAGGGTCAGGAACCAGGACA	0.587													5	40					0	0	0.001168	0	0
FLT4	2324	broad.mit.edu	37	5	180055958	180055958	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:180055958G>A	uc003mma.3	-	8	1106	c.1027C>T	c.(1027-1029)CTG>TTG	p.L343L	FLT4_uc003mlz.3_Silent_p.L343L|FLT4_uc003mmb.1_5'UTR|FLT4_uc011dgy.1_Silent_p.L343L|FLT4_uc011dgz.1_Silent_p.S286S	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	343	Ig-like C2-type 4.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GTGGCCTCCAGGATGGGTCCT	0.622									Congenital_Hereditary_Lymphedema				6	27					0	0	0.001984	0	0
SERPINB9	5272	broad.mit.edu	37	6	2893707	2893707	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:2893707C>T	uc003mug.2	-	5	626	c.505G>A	c.(505-507)GGA>AGA	p.G169R	uc003mue.2_Intron|SERPINB9_uc003muf.2_5'Flank	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	169					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TTCCACTTTCCTTTGAAGTAG	0.403													11	114					0	0	0.008291	0	0
SLC22A23	63027	broad.mit.edu	37	6	3410537	3410537	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:3410537G>A	uc003mvm.3	-	3	798	c.798C>T	c.(796-798)TTC>TTT	p.F266F	SLC22A23_uc003mvn.3_5'UTR|SLC22A23_uc003mvo.3_5'UTR|SLC22A23_uc003mvp.1_RNA|SLC22A23_uc010jnn.2_Silent_p.F266F|SLC22A23_uc010jno.2_Silent_p.F266F	NM_015482	NP_056297	A1A5C7	S22AN_HUMAN	solute carrier family 22, member 23 isoform a	266	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			ovary(1)	1	Ovarian(93;0.0493)	all_hematologic(90;0.0905)				AGATCAGAATGAAGATGATGG	0.468													5	26					0	0	0.000602	0	0
FAM50B	26240	broad.mit.edu	37	6	3850990	3850990	+	Silent	SNP	C	T	T	rs149589937		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:3850990C>T	uc003mvu.2	+	2	1057	c.945C>T	c.(943-945)CCC>CCT	p.P315P		NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	315						nucleus				pancreas(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				CCTATGACCCCGAGAAGAAGT	0.622													12	38					0	0	0.002450	0	0
DSP	1832	broad.mit.edu	37	6	7569424	7569424	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:7569424C>T	uc003mxp.1	+	12	1704	c.1425C>T	c.(1423-1425)ATC>ATT	p.I475I	DSP_uc003mxq.1_Silent_p.I475I	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	475	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TACAGAAAATCGTGCATAAGG	0.468													8	93					0	0	0.004482	0	0
DSP	1832	broad.mit.edu	37	6	7580518	7580518	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:7580518G>A	uc003mxp.1	+	23	4374	c.4095G>A	c.(4093-4095)CAG>CAA	p.Q1365Q	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1365	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TAAAAAATCAGTTTGAGACCG	0.458													4	29					0	0	0.009096	0	0
DSP	1832	broad.mit.edu	37	6	7580796	7580796	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:7580796G>A	uc003mxp.1	+	23	4652	c.4373G>A	c.(4372-4374)CGA>CAA	p.R1458Q	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1458	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACTCAGATGCGAACAGAGGAG	0.463													5	60					0	0	0.000602	0	0
DSP	1832	broad.mit.edu	37	6	7585673	7585673	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:7585673C>T	uc003mxp.1	+	24	8457	c.8178C>T	c.(8176-8178)TTC>TTT	p.F2726F	DSP_uc003mxq.1_Silent_p.F2127F	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2726	Plectin 16.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCCAGCGCTTCCTGGAGTTCC	0.552													6	83					0	0	0.001168	0	0
SYCP2L	221711	broad.mit.edu	37	6	10926589	10926589	+	Silent	SNP	G	A	A	rs147164289		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:10926589G>A	uc003mzo.2	+	16	1532	c.1236G>A	c.(1234-1236)ACG>ACA	p.T412T	SYCP2L_uc011din.1_Silent_p.T253T|SYCP2L_uc010jow.2_Silent_p.T32T	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	412						nucleus		p.T412T(1)		ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			CTGACCAGACGAAAATCTCCT	0.348													35	132					0	0	0.009718	0	0
ELOVL2	54898	broad.mit.edu	37	6	11000335	11000335	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:11000335C>T	uc003mzp.3	-	4	479	c.318G>A	c.(316-318)GGG>GGA	p.G106G		NM_017770	NP_060240	Q9NXB9	ELOV2_HUMAN	elongation of very long chain fatty acids-like	106					fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Breast(50;0.0418)|Ovarian(93;0.0919)	all_hematologic(90;0.117)	Epithelial(50;0.176)			TGTCAGCTTCCCCTGCGCTGG	0.468													6	57					0	0	0.001984	0	0
JARID2	3720	broad.mit.edu	37	6	15517407	15517407	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:15517407G>A	uc003nbj.2	+	17	3710	c.3466G>A	c.(3466-3468)GAA>AAA	p.E1156K	JARID2_uc011div.1_Missense_Mutation_p.E984K	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	1156					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				ACAAGAGAACGAAAACGTCGT	0.602													12	34					0	0	0.010729	0	0
NUP153	9972	broad.mit.edu	37	6	17637557	17637557	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:17637557G>A	uc003ncd.1	-	16	2491	c.2291C>T	c.(2290-2292)TCG>TTG	p.S764L	NUP153_uc011dje.1_Missense_Mutation_p.S795L|NUP153_uc010jpl.1_Missense_Mutation_p.S722L	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	764					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			AGCACTTTCCGAAACCACTGT	0.433													8	69					0	0	0.003080	0	0
E2F3	1871	broad.mit.edu	37	6	20490568	20490568	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:20490568C>T	uc003nda.2	+	7	1632	c.1305C>T	c.(1303-1305)CTC>CTT	p.L435L		NM_001949	NP_001940	O00716	E2F3_HUMAN	E2F transcription factor 3	435	Transactivation (Potential).|Retinoblastoma protein binding (Potential).				G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1	all_cancers(95;0.154)|all_epithelial(95;0.0585)|Breast(50;0.146)|Ovarian(93;0.148)		OV - Ovarian serous cystadenocarcinoma(7;0.0068)|all cancers(50;0.0148)|Epithelial(50;0.0562)			AGGACTATCTCCTGAGCCTCG	0.512													39	404					0	0	0.008740	0	0
NRSN1	140767	broad.mit.edu	37	6	24146025	24146025	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:24146025G>A	uc010jpq.1	+	4	676	c.439G>A	c.(439-441)GAA>AAA	p.E147K		NM_080723	NP_542454	Q8IZ57	NRSN1_HUMAN	neurensin 1	147					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle					0						CTCCAAAGAAGAAAAATTCCT	0.502													8	59					0	0	0.006214	0	0
GPLD1	2822	broad.mit.edu	37	6	24456865	24456865	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:24456865C>T	uc003ned.1	-	13	1120	c.1009G>A	c.(1009-1011)GAT>AAT	p.D337N	GPLD1_uc010jpr.1_Missense_Mutation_p.D174N|GPLD1_uc010jps.1_Missense_Mutation_p.D337N	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	337						extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						GACATGGAATCCTGAAATAAA	0.398													7	96					0	0	0.001984	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24533816	24533816	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:24533816G>A	uc003neg.2	+	10	1512	c.1484G>A	c.(1483-1485)GGA>GAA	p.G495E	ALDH5A1_uc003nef.2_Missense_Mutation_p.G508E	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	495					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	GTCAACGAAGGATTAATTTCC	0.512													10	85					0	0	0.008291	0	0
KIAA0319	9856	broad.mit.edu	37	6	24581231	24581231	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:24581231C>T	uc011djo.1	-	7	1439	c.1202G>A	c.(1201-1203)GGA>GAA	p.G401E	KIAA0319_uc011djp.1_Missense_Mutation_p.G356E|KIAA0319_uc003neh.1_Missense_Mutation_p.G401E|KIAA0319_uc011djq.1_Missense_Mutation_p.G392E|KIAA0319_uc011djr.1_Missense_Mutation_p.G401E|KIAA0319_uc010jpt.1_5'UTR	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	401	PKD 1.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						GACATAAAGTCCGACGGACAA	0.428											OREG0017229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	68					0	0	0.003954	0	0
SLC17A4	10050	broad.mit.edu	37	6	25777040	25777040	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:25777040G>A	uc003nfe.2	+	10	1240	c.1121G>A	c.(1120-1122)GGG>GAG	p.G374E	SLC17A4_uc011djx.1_Missense_Mutation_p.G144E|SLC17A4_uc003nff.1_Missense_Mutation_p.G163E|SLC17A4_uc003nfg.2_Missense_Mutation_p.G311E|SLC17A4_uc010jqa.2_Intron	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	374	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						CCTACCCCAGGGGTTCTCTTC	0.562													9	93					0	0	0.010729	0	0
SLC17A2	10246	broad.mit.edu	37	6	25917050	25917050	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:25917050G>A	uc011dkb.1	-	7	876	c.793C>T	c.(793-795)CCC>TCC	p.P265S	SLC17A2_uc011dkc.1_Missense_Mutation_p.P265S|SLC17A2_uc003nfl.2_Missense_Mutation_p.P265S			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	265					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						GCCTTTATGGGGACAGCTCGT	0.493													4	35					0	0	0.009096	0	0
BTN1A1	696	broad.mit.edu	37	6	26505269	26505269	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:26505269G>A	uc003nif.3	+	3	564	c.544G>A	c.(544-546)GGA>AGA	p.G182R		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	182	Extracellular (Potential).|Ig-like V-type 2.					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						AACTTCCAAGGGAGAGAAGTT	0.478													4	37					0	0	0.000602	0	0
ZNF184	7738	broad.mit.edu	37	6	27419180	27419180	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:27419180G>A	uc003njj.2	-	5	2969	c.2158C>T	c.(2158-2160)CAT>TAT	p.H720Y	ZNF184_uc010jqv.2_Missense_Mutation_p.H720Y|ZNF184_uc003nji.2_Missense_Mutation_p.H720Y	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	720	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTCCTGAATGAATTCTCTGG	0.398													12	114					0	0	0.013537	0	0
OR2B2	81697	broad.mit.edu	37	6	27879938	27879938	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:27879938T>G	uc011dkw.1	-	1	160	c.160A>C	c.(160-162)AAA>CAA	p.K54Q		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTGTGGAGTTTGAAATCCACA	0.393													3	37					0	0	0.004672	0	0
OR2B6	26212	broad.mit.edu	37	6	27925818	27925818	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:27925818C>T	uc011dkx.1	+	1	800	c.800C>T	c.(799-801)TCC>TTC	p.S267F		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCGCCCAGCTCCAAGGACCAA	0.453													7	86					0	0	0.003080	0	0
SCAND3	114821	broad.mit.edu	37	6	28541181	28541181	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:28541181G>A	uc003nlo.2	-	4	3103	c.2485C>T	c.(2485-2487)CCG>TCG	p.P829S		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	829					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ttggcaaccggaagtgctact	0													22	106					0	0	0.014323	0	0
SCAND3	114821	broad.mit.edu	37	6	28543585	28543585	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:28543585C>T	uc003nlo.2	-	3	1515	c.897G>A	c.(895-897)CGG>CGA	p.R299R		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	299					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTAAGTAATACCGTATTTTAT	0.403													9	111					0	0	0.006214	0	0
OR2J2	26707	broad.mit.edu	37	6	29142132	29142132	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:29142132G>A	uc011dlm.1	+	1	822	c.720G>A	c.(718-720)AGG>AGA	p.R240R		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAGTGTTTAGGACATGTGGAG	0.458													9	136					0	0	0.004482	0	0
OR2J2	26707	broad.mit.edu	37	6	29142318	29142318	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:29142318G>A	uc011dlm.1	+	1	1008	c.906G>A	c.(904-906)GCG>GCA	p.A302A		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAGGGGCAGCGAAGAGACTAT	0.453													8	84					0	0	0.003080	0	0
OR14J1	442191	broad.mit.edu	37	6	29274662	29274662	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:29274662C>T	uc011dln.1	+	1	196	c.196C>T	c.(196-198)CTT>TTT	p.L66F		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GCACCTCTCTCTTCTGGACCT	0.473													13	271					0	0	0.001855	0	0
OR10C1	442194	broad.mit.edu	37	6	29408542	29408542	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:29408542C>T	uc011dlp.1	+	1	750	c.750C>T	c.(748-750)TTC>TTT	p.F250F	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTCCCTCTTCTATGGCACCG	0.587													21	221					0	0	0.003330	0	0
GABBR1	2550	broad.mit.edu	37	6	29591248	29591248	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:29591248G>A	uc003nmt.3	-	8	1133	c.797C>T	c.(796-798)TCC>TTC	p.S266F	GABBR1_uc003nmp.3_Missense_Mutation_p.S149F|GABBR1_uc003nms.3_Missense_Mutation_p.S149F|GABBR1_uc003nmu.3_Missense_Mutation_p.S204F|GABBR1_uc011dlr.1_Missense_Mutation_p.S89F|GABBR1_uc011dls.1_Missense_Mutation_p.S266F	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	266	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	GGAGCCATAGGAAAGCTGTGG	0.562													3	15					0	0	0.004672	0	0
TRIM31	11074	broad.mit.edu	37	6	30078327	30078327	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:30078327C>T	uc003npg.1	-	4	752	c.642G>A	c.(640-642)GGG>GGA	p.G214G	TRIM31_uc003npi.3_RNA	NM_007028	NP_008959	Q9BZY9	TRI31_HUMAN	tripartite motif protein 31	214						mitochondrion	ligase activity|zinc ion binding			lung(1)	1						CATAGTGTTTCCCCGCTTCCG	0.512													22	78					0	0	0.014323	0	0
DDR1	780	broad.mit.edu	37	6	30864868	30864868	+	Silent	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:30864868T>A	uc003nrr.2	+	15	2206	c.1947T>A	c.(1945-1947)CCT>CCA	p.P649P	DDR1_uc010jse.2_Silent_p.P612P|DDR1_uc003nrq.2_Silent_p.P612P|DDR1_uc003nrs.2_Silent_p.P649P|DDR1_uc003nrt.2_Silent_p.P612P|DDR1_uc011dms.1_Silent_p.P630P|DDR1_uc003nru.2_Silent_p.P612P|DDR1_uc003nrv.2_Silent_p.P649P|DDR1_uc003nrw.1_Silent_p.P384P|DDR1_uc003nry.1_RNA|DDR1_uc003nrx.1_RNA|DDR1_uc003nrz.1_5'UTR	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	649	Cytoplasmic (Potential).|Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	AGGGACACCCTTTGCTGGTAG	0.537													7	76					0	0	0.003080	0	0
DPCR1	135656	broad.mit.edu	37	6	30920802	30920802	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:30920802G>A	uc003nsg.2	+	3	4090	c.4090G>A	c.(4090-4092)GAT>AAT	p.D1364N		NM_080870	NP_543146	Q3MIW9	DPCR1_HUMAN	diffuse panbronchiolitis critical region 1	488	Cytoplasmic (Potential).					integral to membrane					0						CCAGTACAATGATGCAGAGGA	0.537													5	24					0	0	0.000602	0	0
BAT2	7916	broad.mit.edu	37	6	31597589	31597589	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:31597589C>A	uc003nvb.3	+	14	2470	c.2221C>A	c.(2221-2223)CTA>ATA	p.L741I	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.L741I	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	741	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						TCGTCCCCCTCTAGACTTCTA	0.577													9	69					0.000673444	0.000725214	0.008291	1	0
LY6G5B	58496	broad.mit.edu	37	6	31639771	31639771	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:31639771C>T	uc003nvt.1	+	3	318	c.318C>T	c.(316-318)TCC>TCT	p.S106S	CSNK2B_uc003nvs.1_3'UTR	NM_021221	NP_067044	Q8NDX9	LY65B_HUMAN	lymphocyte antigen 6 complex G5B precursor	106	UPAR/Ly6.					extracellular region					0						ATTGCAACTCCTGGTCAAGCC	0.562													36	324					0	0	0.006230	0	0
LY6G6D	58530	broad.mit.edu	37	6	31683147	31683147	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:31683147T>G	uc003nwf.1	+	1	15	c.15T>G	c.(13-15)TTT>TTG	p.F5L	BAT5_uc011dnz.1_5'Flank|LY6G6F_uc003nwb.1_Intron|LY6G6E_uc011dob.1_5'Flank|LY6G6E_uc003nwc.2_5'Flank|LY6G6E_uc003nwd.2_5'Flank|LY6G6E_uc003nwe.2_5'Flank|LY6G6D_uc003nwg.1_5'UTR	NM_021246	NP_067069	O95868	LY66D_HUMAN	lymphocyte antigen 6 complex G6D precursor	5						anchored to membrane|filopodium|plasma membrane				lung(1)	1						AACCCCAGTTTGTTGGGATCT	0.657													23	271					0	0	0.005443	0	0
C6orf25	80739	broad.mit.edu	37	6	31691464	31691464	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:31691464G>A	uc011doc.1	+	2	110	c.110G>A	c.(109-111)GGA>GAA	p.G37E	LY6G6C_uc003nwh.2_5'Flank|LY6G6C_uc010jtd.2_5'Flank|C6orf25_uc003nwk.2_Missense_Mutation_p.G37E|C6orf25_uc011dod.1_Missense_Mutation_p.G37E|C6orf25_uc011doe.1_Missense_Mutation_p.G37E|C6orf25_uc003nwo.2_Missense_Mutation_p.G37E|C6orf25_uc003nwn.2_Missense_Mutation_p.G37E	NM_138272	NP_612116	O95866	G6B_HUMAN	G6B protein isoform G6b-B precursor	37	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity				0						TCCTGCGGAGGAGTCTCTCAT	0.672													7	157					0	0	0.004482	0	0
SLC44A4	80736	broad.mit.edu	37	6	31833142	31833142	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:31833142G>A	uc010jti.2	-	17	1776	c.1710C>T	c.(1708-1710)TTC>TTT	p.F570F	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	570	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	CTGAGACACAGAAATTCTTCC	0.557													47	405					0	0	0.014410	0	0
PRRT1	80863	broad.mit.edu	37	6	32118437	32118437	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:32118437G>A	uc003nzt.2	-	2	382	c.266C>T	c.(265-267)CCT>CTT	p.P89L	PRRT1_uc003nzs.2_Missense_Mutation_p.P130L|PRRT1_uc003nzu.2_Intron|PPT2_uc003nzw.2_5'Flank	NM_030651	NP_085154	Q99946	PRRT1_HUMAN	NG5 protein	89					response to biotic stimulus	integral to membrane				breast(1)	1						AGGGCCGGGAGGGGCGTGGTG	0.751													4	27					0	0	0.000602	0	0
NOTCH4	4855	broad.mit.edu	37	6	32170246	32170246	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:32170246C>T	uc003obb.2	-	21	3501	c.3362G>A	c.(3361-3363)GGG>GAG	p.G1121E	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_Intron|NOTCH4_uc011dpv.1_Intron	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1121	EGF-like 28.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GTCAGGACCCCCATAGCCACT	0.657													34	274					0	0	0.003271	0	0
NOTCH4	4855	broad.mit.edu	37	6	32185774	32185774	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:32185774G>A	uc003obb.2	-	9	1761	c.1622C>T	c.(1621-1623)CCT>CTT	p.P541L	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.P541L	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	541	EGF-like 13; calcium-binding (Potential).|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GTACTCACCAGGCAGGCAGAT	0.597													14	206					0	0	0.004007	0	0
HLA-DQB1	3119	broad.mit.edu	37	6	32629807	32629807	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:32629807C>T	uc003obw.2	-	3	680	c.598G>A	c.(598-600)GGA>AGA	p.G200R	HLA-DQB1_uc010juc.1_Missense_Mutation_p.G155R|HLA-DQB1_uc003obv.2_Missense_Mutation_p.G200R|HLA-DQB1_uc011dqd.1_Missense_Mutation_p.G200R|HLA-DQB1_uc011dqe.1_3'UTR	NM_002123	NP_002114	P01920	DQB1_HUMAN	major histocompatibility complex, class II, DQ	200	Extracellular (Potential).|Beta-2.|Ig-like C1-type.		GD -> A (in allele DQB1*03:09).		antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TAGACATCTCCACGCTGGGGA	0.567									Melanoma_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia|T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Sj_gren_syndrome				8	67					0	0	0.003080	0	0
RGL2	5863	broad.mit.edu	37	6	33263311	33263311	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:33263311G>A	uc003odv.2	-	7	1127	c.994C>T	c.(994-996)CTG>TTG	p.L332L	RGL2_uc003odu.2_5'UTR|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_Silent_p.L250L|RGL2_uc011drb.1_Silent_p.L250L	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	332	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						CACTTCTCCAGGAGCCGGGCC	0.602													6	25					0	0	0.001168	0	0
DAXX	1616	broad.mit.edu	37	6	33289562	33289563	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:33289562_33289563GG>AA	uc003oec.2	-	2	344_345	c.140_141CC>TT	c.(139-141)GCC>GTT	p.A47V	DAXX_uc011drd.1_Intron|DAXX_uc011dre.1_Missense_Mutation_p.A59V|DAXX_uc003oed.2_Missense_Mutation_p.A47V|DAXX_uc010juw.2_5'UTR	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	47	Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						TGCTTCCTCTGGCCCCATGAGG	0.589			Mis|F|N		Pancreatic neuroendocrine tumors								37	197					0	0	0.004672	0	0
PHF1	5252	broad.mit.edu	37	6	33383017	33383017	+	Silent	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:33383017A>G	uc003oeh.2	+	13	1481	c.1245A>G	c.(1243-1245)TCA>TCG	p.S415S	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Intron|PHF1_uc010jux.2_Silent_p.S215S	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	415					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				TCTAGGCCTCAGTGTCTCCAC	0.607													7	108					0	0	0.004482	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33405666	33405667	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:33405666_33405667CC>TT	uc011dri.1	+	8	1179_1180	c.984_985CC>TT	c.(982-987)TACCGT>TATTGT	p.R329C	SYNGAP1_uc003oeo.1_Missense_Mutation_p.R314C|SYNGAP1_uc010juy.2_Missense_Mutation_p.R314C|SYNGAP1_uc010juz.2_Missense_Mutation_p.R41C	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	329	C2.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						TGCATCTGTACCGTGACTCAGA	0.624													6	60					0	0	0.004672	0	0
ITPR3	3710	broad.mit.edu	37	6	33641370	33641370	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:33641370C>T	uc011drk.1	+	23	3150	c.2931C>T	c.(2929-2931)TTC>TTT	p.F977F		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	977	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TTCTCCAGTTCATCCTCAATG	0.557													30	161					0	0	0.013726	0	0
SCUBE3	222663	broad.mit.edu	37	6	35213058	35213058	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:35213058A>T	uc003okf.1	+	19	2461	c.2455A>T	c.(2455-2457)AAC>TAC	p.N819Y	SCUBE3_uc003okg.1_Missense_Mutation_p.N818Y|SCUBE3_uc003okh.1_Missense_Mutation_p.N706Y	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	819	CUB.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						TGAGTCCCCCAACTACCCGGG	0.547													10	82					0	0	0.008291	0	0
FANCE	2178	broad.mit.edu	37	6	35428335	35428335	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:35428335C>T	uc003oko.1	+	8	1508	c.1323C>T	c.(1321-1323)ATC>ATT	p.I441I	FANCE_uc010jvw.1_Silent_p.I434I	NM_021922	NP_068741	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	441					DNA repair	nucleoplasm	protein binding			ovary(1)|lung(1)|skin(1)	3						GCAGACAGATCTTGGAGCTGC	0.572			N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				5	42					0	0	0.001168	0	0
FKBP5	2289	broad.mit.edu	37	6	35543668	35543668	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:35543668C>T	uc011dte.1	-	11	1521	c.1318G>A	c.(1318-1320)GAA>AAA	p.E440K	FKBP5_uc003okx.2_Missense_Mutation_p.E440K|FKBP5_uc011dtf.1_Missense_Mutation_p.E261K|FKBP5_uc003oky.2_Missense_Mutation_p.E440K	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	440					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						GTTCCTTTTTCATTAGTGACC	0.468													39	196					0	0	0.011902	0	0
FKBP5	2289	broad.mit.edu	37	6	35543679	35543679	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:35543679C>G	uc011dte.1	-	11	1510	c.1307G>C	c.(1306-1308)GGG>GCG	p.G436A	FKBP5_uc003okx.2_Missense_Mutation_p.G436A|FKBP5_uc011dtf.1_Missense_Mutation_p.G257A|FKBP5_uc003oky.2_Missense_Mutation_p.G436A	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	436					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						ATTAGTGACCCCTTCTGAAGT	0.448													39	195					0	0	0.009718	0	0
SLC26A8	116369	broad.mit.edu	37	6	35927554	35927554	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:35927554G>A	uc003olm.2	-	15	1779	c.1668C>T	c.(1666-1668)TTC>TTT	p.F556F	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Silent_p.F138F|SLC26A8_uc003oln.2_Silent_p.F556F|SLC26A8_uc003oll.2_Silent_p.F451F	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	556	STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						TGCAGCACTGGAAGATTTTCA	0.393													18	79					0	0	0.006122	0	0
MAPK14	1432	broad.mit.edu	37	6	36020501	36020501	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:36020501T>A	uc003olp.2	+	2	623	c.142T>A	c.(142-144)TTA>ATA	p.L48I	MAPK14_uc011dth.1_Missense_Mutation_p.L48I|MAPK14_uc003olo.2_Missense_Mutation_p.L48I|MAPK14_uc003olq.2_Missense_Mutation_p.L48I|MAPK14_uc003olr.2_Missense_Mutation_p.L48I|MAPK14_uc011dti.1_5'UTR	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1	48	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						AAAAACGGGGTTACGTGTGGC	0.383													7	73					0	0	0.006214	0	0
BRPF3	27154	broad.mit.edu	37	6	36172537	36172537	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:36172537C>T	uc003olv.3	+	3	1775	c.1551C>T	c.(1549-1551)GTC>GTT	p.V517V	BRPF3_uc010jwb.2_Silent_p.V517V|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Silent_p.V517V	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	517					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GGAATGGTGTCCCTCTTATCC	0.522													11	117					0	0	0.010729	0	0
BRPF3	27154	broad.mit.edu	37	6	36178189	36178189	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:36178189C>T	uc003olv.3	+	6	2287	c.2063C>T	c.(2062-2064)GCC>GTC	p.A688V	BRPF3_uc010jwb.2_Missense_Mutation_p.A688V|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Missense_Mutation_p.A688V	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	688					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CTGGGAGGGGCCATCCTACGG	0.483													9	71					0	0	0.010729	0	0
C6orf222	389384	broad.mit.edu	37	6	36293117	36293117	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:36293117G>A	uc003oly.2	-	6	1289	c.1111C>T	c.(1111-1113)CCA>TCA	p.P371S		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	371										skin(2)|ovary(1)|breast(1)	4						CTCTCTGATGGGGTGGGAAGC	0.537													10	53					0	0	0.006214	0	0
MDGA1	266727	broad.mit.edu	37	6	37622271	37622271	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:37622271G>A	uc003onu.1	-	6	1940	c.761C>T	c.(760-762)CCT>CTT	p.P254L	MDGA1_uc003onw.3_5'Flank	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	254	Ig-like 3.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						ATTCTCCCCAGGGTTCACCAC	0.627													25	77					0	0	0.003954	0	0
ZFAND3	60685	broad.mit.edu	37	6	38029438	38029439	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:38029438_38029439CC>TT	uc003onx.2	+	3	597_598	c.182_183CC>TT	c.(181-183)TCC>TTT	p.S61F		NM_021943	NP_068762	Q9H8U3	ZFAN3_HUMAN	zinc finger, AN1-type domain 3	61							DNA binding|zinc ion binding			ovary(1)	1						GATTTGTTTTCCGAAGAGACCA	0.431													5	45					0	0	0.004672	0	0
GLP1R	2740	broad.mit.edu	37	6	39046896	39046896	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:39046896C>T	uc003ooj.3	+	10	1023	c.963C>T	c.(961-963)TTC>TTT	p.F321F	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	321	Helical; Name=5; (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	AGGTGAACTTCCTCATCTTTG	0.557													15	116					0	0	0.004007	0	0
KCNK5	8645	broad.mit.edu	37	6	39159209	39159209	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:39159209C>T	uc003oon.2	-	5	1321	c.957G>A	c.(955-957)GGG>GGA	p.G319G		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	319	Cytoplasmic (Potential).				excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						GGCCCGTCTCCCCACCCCCGC	0.617													9	83					0	0	0.010729	0	0
KCNK5	8645	broad.mit.edu	37	6	39162519	39162519	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:39162519G>A	uc003oon.2	-	3	680	c.316C>T	c.(316-318)CCC>TCC	p.P106S		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	106					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						GGGGTCTTGGGAGCCACATTG	0.597													5	61					0	0	0.001984	0	0
KCNK5	8645	broad.mit.edu	37	6	39162536	39162536	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:39162536C>T	uc003oon.2	-	3	663	c.299G>A	c.(298-300)GGA>GAA	p.G100E		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	100					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						ATTGCCATATCCTGAGGAAGG	0.557													7	60					0	0	0.001984	0	0
KCNK16	83795	broad.mit.edu	37	6	39285722	39285722	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:39285722C>T	uc003ooq.2	-	3	349	c.335G>A	c.(334-336)GGG>GAG	p.G112E	KCNK16_uc003oor.3_Missense_Mutation_p.G112E|KCNK16_uc010jwy.2_Missense_Mutation_p.G112E|KCNK16_uc011dtz.1_Missense_Mutation_p.G112E	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	112						integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						TGCCAGGTTCCCATATCCTGC	0.562													7	34					0	0	0.003080	0	0
TREM2	54209	broad.mit.edu	37	6	41129230	41129230	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:41129230C>T	uc003opy.2	-	2	264	c.162G>A	c.(160-162)CTG>CTA	p.L54L	TREM2_uc003opz.2_Silent_p.L84L|TREM2_uc010jxl.1_Silent_p.L84L	NM_018965	NP_061838	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	54	Ig-like V-type.|Extracellular (Potential).				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCTTCTCTCCCAGCTGGCGGC	0.632													5	38					0	0	0.000602	0	0
TREML3	340206	broad.mit.edu	37	6	41185544	41185544	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:41185544G>A	uc003oqb.2	-	1		c.142C>T				NR_027256				Homo sapiens TREM-like transcript 3 (TLT3) mRNA, partial cds.												0						ATTGTGTAATGAGACTTCTGA	0.493													11	28					0	0	0.013537	0	0
TREML4	285852	broad.mit.edu	37	6	41204223	41204223	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:41204223G>A	uc003oqc.2	+	5	611	c.507_splice	c.e5-1	p.R169_splice	TREML4_uc003oqd.2_Splice_Site	NM_198153	NP_937796	Q6UXN2	TRML4_HUMAN	triggering receptor expressed on myeloid							extracellular region				breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CTTCCCTGCAGGAAATCAAGA	0.592													4	34					0	0	0.000602	0	0
TREML4	285852	broad.mit.edu	37	6	41204226	41204226	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:41204226A>C	uc003oqc.2	+	5	613	c.509A>C	c.(508-510)AAA>ACA	p.K170T	TREML4_uc003oqd.2_RNA	NM_198153	NP_937796	Q6UXN2	TRML4_HUMAN	triggering receptor expressed on myeloid	170						extracellular region				breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CCCTGCAGGAAATCAAGAGCC	0.602													4	34					0	0	0.000602	0	0
TREM1	54210	broad.mit.edu	37	6	41250362	41250362	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:41250362C>T	uc003oqf.1	-	2	241	c.177G>A	c.(175-177)AGG>AGA	p.R59R	TREM1_uc003oqg.1_Silent_p.R59R	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	59	Extracellular (Potential).|Ig-like V-type.				blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	TCTCTCCGTCCCTTATTATCT	0.493													6	91					0	0	0.003080	0	0
TFEB	7942	broad.mit.edu	37	6	41654901	41654901	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:41654901C>T	uc003oqs.1	-	8	1036	c.734G>A	c.(733-735)AGG>AAG	p.R245K	TFEB_uc003oqt.1_Missense_Mutation_p.R245K|TFEB_uc003oqu.1_Missense_Mutation_p.R259K|TFEB_uc003oqv.1_Missense_Mutation_p.R245K|TFEB_uc003oqr.1_Missense_Mutation_p.R160K	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	245	Basic motif.				embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			CCTTCGTCTCCTTTCAACTAA	0.552			T	ALPHA	renal (childhood epithelioid)								9	39					0	0	0.006214	0	0
TFEB	7942	broad.mit.edu	37	6	41655724	41655724	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:41655724G>A	uc003oqs.1	-	6	894	c.592C>T	c.(592-594)CCC>TCC	p.P198S	TFEB_uc003oqt.1_Missense_Mutation_p.P198S|TFEB_uc003oqu.1_Missense_Mutation_p.P212S|TFEB_uc003oqv.1_Missense_Mutation_p.P198S|TFEB_uc010jxo.1_Missense_Mutation_p.P198S|TFEB_uc003oqr.1_Missense_Mutation_p.P113S	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	198					embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GTGACCTGGGGGTCGCTGCTG	0.662			T	ALPHA	renal (childhood epithelioid)								12	63					0	0	0.013537	0	0
TRERF1	55809	broad.mit.edu	37	6	42227387	42227387	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:42227387C>T	uc003osd.2	-	9	2522	c.1959G>A	c.(1957-1959)AAG>AAA	p.K653K	TRERF1_uc011duq.1_Silent_p.K570K|TRERF1_uc003osb.2_Silent_p.K409K|TRERF1_uc003osc.2_Silent_p.K409K|TRERF1_uc003ose.2_Silent_p.K673K	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	653	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGTGCCGGAACTTTTTCTTCT	0.617													14	65					0	0	0.003163	0	0
TRERF1	55809	broad.mit.edu	37	6	42236220	42236220	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:42236220G>A	uc003osd.2	-	5	1672	c.1109C>T	c.(1108-1110)CCC>CTC	p.P370L	TRERF1_uc011duq.1_Missense_Mutation_p.P370L|TRERF1_uc003osb.2_Missense_Mutation_p.P209L|TRERF1_uc003osc.2_Missense_Mutation_p.P209L|TRERF1_uc003ose.2_Missense_Mutation_p.P370L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	370	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGAGCCCAGGGGAATCAGCTG	0.607													5	113					0	0	0.001984	0	0
UBR2	23304	broad.mit.edu	37	6	42637833	42637833	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:42637833C>T	uc011dur.1	+	35	3885	c.3885C>T	c.(3883-3885)ATC>ATT	p.I1295I	UBR2_uc011dus.1_Silent_p.I940I|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1295					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			ACTTCAGGATCCCTTATTCTG	0.378													5	34					0	0	0.000602	0	0
PEX6	5190	broad.mit.edu	37	6	42942623	42942623	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:42942623G>A	uc003otf.2	-	2	1129	c.1036C>T	c.(1036-1038)CAG>TAG	p.Q346*	PEX6_uc010jya.2_RNA	NM_000287	NP_000278	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	346					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)	1			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			CTGGGTATCTGAAAGTGCCGG	0.478													23	86					0	0	0.002780	0	0
CUL7	9820	broad.mit.edu	37	6	43018889	43018889	+	Silent	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:43018889G>T	uc003otq.2	-	4	1353	c.1050C>A	c.(1048-1050)TCC>TCA	p.S350S	CUL7_uc011dvb.1_Silent_p.S434S|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	350					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			ACCTCCTGAAGGAGGGCTGAG	0.612													10	85					2.27111e-07	2.45676e-07	0.013537	1	0
ZNF318	24149	broad.mit.edu	37	6	43308624	43308624	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:43308624G>A	uc003oux.2	-	9	3477	c.3399C>T	c.(3397-3399)ATC>ATT	p.I1133I	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1133					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			AAAATCCACTGATGGGAACCA	0.448													7	59					0	0	0.001984	0	0
ZNF318	24149	broad.mit.edu	37	6	43323411	43323411	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:43323411G>A	uc003oux.2	-	4	1739	c.1661C>T	c.(1660-1662)CCC>CTC	p.P554L	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	554					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GCTCCCAAGGGGCTTTGGTAC	0.478													15	168					0	0	0.003163	0	0
CAPN11	11131	broad.mit.edu	37	6	44141081	44141081	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:44141081G>A	uc003owt.1	+	7	827	c.789G>A	c.(787-789)AGG>AGA	p.R263R		NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	263	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGCTCCTTAGGAAGGCCGTGG	0.408													5	25					0	0	0.000602	0	0
CDC5L	988	broad.mit.edu	37	6	44387332	44387332	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:44387332C>T	uc003oxl.2	+	9	1498	c.1239C>T	c.(1237-1239)TTC>TTT	p.F413F		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	413	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTACTCCATTCAGGTATTGTA	0.368													7	60					0	0	0.001984	0	0
ENPP5	59084	broad.mit.edu	37	6	46129414	46129414	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:46129414C>T	uc003oxz.1	-	4	1291	c.1083G>A	c.(1081-1083)AAG>AAA	p.K361K	ENPP5_uc003oya.1_Silent_p.K361K|ENPP5_uc011dvz.1_Silent_p.K267K|ENPP5_uc010jzc.1_3'UTR	NM_021572	NP_067547	Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	361						extracellular region|integral to membrane	hydrolase activity				0						TTGAGAAATTCTTTCTGAAGG	0.418													30	311					0	0	0.003755	0	0
GPR116	221395	broad.mit.edu	37	6	46826169	46826169	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:46826169C>T	uc003oyo.3	-	17	3760	c.3471G>A	c.(3469-3471)ACG>ACA	p.T1157T	GPR116_uc011dwj.1_Silent_p.T712T|GPR116_uc011dwk.1_Silent_p.T586T|GPR116_uc003oyp.3_Silent_p.T1015T|GPR116_uc003oyq.3_Silent_p.T1157T|GPR116_uc010jzi.1_Silent_p.T829T	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	1157	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CATTCTTCCTCGTATAGACTT	0.557													8	20					0	0	0.004482	0	0
GPR110	266977	broad.mit.edu	37	6	46979809	46979809	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:46979809C>T	uc003oyt.2	-	10	1249	c.1050G>A	c.(1048-1050)TCG>TCA	p.S350S	GPR110_uc011dwl.1_Silent_p.S38S	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	350	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TGCTCAGAATCGACACCACCG	0.488													22	33					0	0	0.012319	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47200576	47200576	+	Silent	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:47200576A>T	uc003oyv.2	-	6	2326	c.1893T>A	c.(1891-1893)ATT>ATA	p.I631I		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	631	Cytoplasmic (Potential).				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			TGACTCCAATAATTTCGAATA	0.483													27	118					0	0	0.010818	0	0
GPR111	222611	broad.mit.edu	37	6	47646785	47646785	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:47646785G>A	uc010jzj.1	+	4	387	c.386G>A	c.(385-387)GGA>GAA	p.G129E	GPR111_uc010jzk.1_Missense_Mutation_p.G61E|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	129	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GACACTCAGGGAAATATGGGG	0.458													10	30					0	0	0.008291	0	0
GPR111	222611	broad.mit.edu	37	6	47649491	47649491	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:47649491C>T	uc010jzj.1	+	6	1197	c.1196C>T	c.(1195-1197)TCT>TTT	p.S399F	GPR111_uc010jzk.1_Missense_Mutation_p.S331F|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	399	Extracellular (Potential).|GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GGCTGGCACTCTGTGGAGAAC	0.453													8	61					0	0	0.004482	0	0
GPR115	221393	broad.mit.edu	37	6	47682166	47682166	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:47682166G>A	uc003oza.1	+	6	1443	c.1185G>A	c.(1183-1185)TCG>TCA	p.S395S	GPR115_uc003oyz.1_Silent_p.S452S|GPR115_uc003ozb.1_Silent_p.S393S	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	395	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						CCTCCAAATCGATGACCGACA	0.473													4	23					0	0	0.009096	0	0
C6orf138	442213	broad.mit.edu	37	6	47846657	47846657	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:47846657G>A	uc011dwm.1	-	3	1957	c.1872C>T	c.(1870-1872)ATC>ATT	p.I624I	C6orf138_uc011dwn.1_Silent_p.I388I	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	641						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						GGTTGAACACGATGAATCGGA	0.483													22	108					0	0	0.003330	0	0
PKHD1	5314	broad.mit.edu	37	6	51907788	51907788	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:51907788G>A	uc003pah.1	-	27	3242	c.2966C>T	c.(2965-2967)CCT>CTT	p.P989L	PKHD1_uc003pai.2_Missense_Mutation_p.P989L	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	989	IPT/TIG 4.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CATTCCAACAGGTAGCAAATC	0.453													4	38					0	0	0.000602	0	0
GSTA5	221357	broad.mit.edu	37	6	52696655	52696655	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:52696655G>A	uc003pba.1	-	7	730	c.660C>T	c.(658-660)TTC>TTT	p.F220F		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	220					glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	ATTAAAACCTGAAAATCTTCC	0.448													12	67					0	0	0.013537	0	0
GCM1	8521	broad.mit.edu	37	6	52993321	52993321	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:52993321T>G	uc003pbp.2	-	6	1203	c.994A>C	c.(994-996)AAC>CAC	p.N332H		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	332						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					TCTGAAGAGTTTTGGGAAGGA	0.468													4	61					0	0	0.009096	0	0
C6orf142	90523	broad.mit.edu	37	6	53989457	53989457	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:53989457G>A	uc003pcg.3	+	3	519	c.406G>A	c.(406-408)GAA>AAA	p.E136K	C6orf142_uc003pcf.2_Missense_Mutation_p.E136K|C6orf142_uc003pch.3_Missense_Mutation_p.E74K|C6orf142_uc011dwz.1_Missense_Mutation_p.E95K|C6orf142_uc011dxa.1_Missense_Mutation_p.E147K	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	136						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					TGTGGACTCCGAAGGGGAAGA	0.502													10	74					0	0	0.008291	0	0
DST	667	broad.mit.edu	37	6	56374636	56374636	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:56374636C>T	uc003pdf.2	-	68	12487	c.12459G>A	c.(12457-12459)CTG>CTA	p.L4153L	DST_uc003pcz.3_Silent_p.L3975L|DST_uc011dxj.1_Silent_p.L4004L|DST_uc011dxk.1_Silent_p.L4015L|DST_uc003pcy.3_Silent_p.L3649L	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6061	Spectrin 12.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CGATGCGTTCCAGGCTCTCAA	0.413													7	40					0	0	0.004482	0	0
LGSN	51557	broad.mit.edu	37	6	64004938	64004938	+	Missense_Mutation	SNP	C	T	T	rs144073733		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:64004938C>T	uc003peh.2	-	2	77	c.43G>A	c.(43-45)GAT>AAT	p.D15N	LGSN_uc003pei.2_Missense_Mutation_p.D15N|LGSN_uc003pej.1_Missense_Mutation_p.D15N	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	15					glutamine biosynthetic process		glutamate-ammonia ligase activity	p.D15N(1)		skin(2)	2					L-Glutamic Acid(DB00142)	TTGCCTTCATCTCTTGTTGAG	0.343													10	40					0	0	0.010729	0	0
PHF3	23469	broad.mit.edu	37	6	64395139	64395139	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:64395139C>T	uc003pep.1	+	3	1542	c.1516C>T	c.(1516-1518)CCG>TCG	p.P506S	PHF3_uc010kaf.1_Missense_Mutation_p.P506S|PHF3_uc003pem.2_Missense_Mutation_p.P459S|PHF3_uc010kag.1_Missense_Mutation_p.P418S|PHF3_uc010kah.1_Missense_Mutation_p.P320S|PHF3_uc003pen.2_Missense_Mutation_p.P418S|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.2_Missense_Mutation_p.P506S	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	506					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CACAGATGCTCCGAAGAAAAT	0.348													4	38					0	0	0.000602	0	0
PHF3	23469	broad.mit.edu	37	6	64422952	64422952	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:64422952T>G	uc003pep.1	+	15	5494	c.5468T>G	c.(5467-5469)TTT>TGT	p.F1823C	PHF3_uc003pen.2_Missense_Mutation_p.F1735C|PHF3_uc011dxs.1_Missense_Mutation_p.F1092C	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1823	Pro-rich.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CCTCCTAATTTTCCCCCACAA	0.502													14	111					0	0	0.004007	0	0
COL9A1	1297	broad.mit.edu	37	6	70926710	70926710	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:70926710G>A	uc003pfg.3	-	38	2815	c.2656C>T	c.(2656-2658)CCT>TCT	p.P886S	COL9A1_uc003pfe.3_Missense_Mutation_p.P435S|COL9A1_uc003pff.3_Missense_Mutation_p.P643S	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	886	Triple-helical region (COL1).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						GGCACTCCAGGAATTCCTGCC	0.622													8	27					0	0	0.004482	0	0
RIMS1	22999	broad.mit.edu	37	6	72596847	72596847	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:72596847G>A	uc003pga.2	+	1	198	c.121G>A	c.(121-123)GAC>AAC	p.D41N		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	41	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GGCAGTGATGGACCGGCAGAA	0.617													4	7					0	0	0.009096	0	0
FILIP1	27145	broad.mit.edu	37	6	76022611	76022611	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:76022611G>A	uc003pia.2	-	5	3310	c.2937C>T	c.(2935-2937)TCC>TCT	p.S979S	FILIP1_uc003phy.1_Silent_p.S979S|FILIP1_uc003phz.2_Silent_p.S880S|FILIP1_uc010kbe.2_Silent_p.S982S|FILIP1_uc003pib.1_Silent_p.S731S	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	979										skin(3)|ovary(1)	4						TTGTGACTGGGGACATGGCTC	0.443													9	53					0	0	0.013537	0	0
IBTK	25998	broad.mit.edu	37	6	82891638	82891638	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:82891638G>A	uc003pjl.1	-	26	4210	c.3683C>T	c.(3682-3684)TCT>TTT	p.S1228F	IBTK_uc011dyu.1_Missense_Mutation_p.S179F|IBTK_uc011dyv.1_Missense_Mutation_p.S1213F|IBTK_uc011dyw.1_Missense_Mutation_p.S1027F|IBTK_uc010kbi.1_Missense_Mutation_p.S922F	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	1228					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TCCTTTAAAAGAAACTTTTTT	0.323													7	16					0	0	0.001984	0	0
DOPEY1	23033	broad.mit.edu	37	6	83847269	83847269	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:83847269T>A	uc003pjs.1	+	21	3768	c.3508T>A	c.(3508-3510)TCA>ACA	p.S1170T	DOPEY1_uc011dyy.1_Missense_Mutation_p.S1161T|DOPEY1_uc010kbl.1_Missense_Mutation_p.S1161T|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1170					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		GGAATCTGCATCAGTTACATC	0.398													9	28					0	0	0.013537	0	0
DOPEY1	23033	broad.mit.edu	37	6	83872624	83872624	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:83872624C>T	uc003pjs.1	+	38	7338	c.7078C>T	c.(7078-7080)CGG>TGG	p.R2360W	DOPEY1_uc011dyy.1_Missense_Mutation_p.R2351W|DOPEY1_uc010kbl.1_Missense_Mutation_p.R2351W|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	2360					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAAACTTCTTCGGAAAAGAGC	0.378													17	62					0	0	0.007413	0	0
NT5E	4907	broad.mit.edu	37	6	86201773	86201773	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:86201773G>A	uc003pko.3	+	8	1995	c.1439G>A	c.(1438-1440)CGA>CAA	p.R480Q	NT5E_uc010kbr.2_Missense_Mutation_p.R430Q	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	480					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	ACCAAGTGTCGAGTGCCCAGT	0.428													22	74					0	0	0.014323	0	0
C6orf162	57150	broad.mit.edu	37	6	88046852	88046852	+	Missense_Mutation	SNP	C	T	T	rs138742161		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:88046852C>T	uc003plp.1	+	3	192	c.103C>T	c.(103-105)CGT>TGT	p.R35C	C6orf164_uc003plr.2_RNA|C6orf162_uc003plq.1_Missense_Mutation_p.R35C	NM_001042493	NP_001035958	Q96KF7	CF162_HUMAN	hypothetical protein LOC57150	35						integral to membrane					0		all_cancers(76;3.81e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.3e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0164)		AACCTTATTTCGTGCTGTGAA	0.433													11	48					0	0	0.008291	0	0
FHL5	9457	broad.mit.edu	37	6	97051592	97051592	+	Missense_Mutation	SNP	C	T	T	rs138154376		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:97051592C>T	uc003pos.1	+	3	508	c.103C>T	c.(103-105)CGT>TGT	p.R35C	FHL5_uc003pot.1_Missense_Mutation_p.R35C	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	35						nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		ATGTTATGATCGTGTATTTTC	0.368													9	64					0	0	0.006214	0	0
SFRS18	25957	broad.mit.edu	37	6	99857203	99857203	+	Silent	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:99857203A>C	uc003ppo.3	-	6	747	c.519T>G	c.(517-519)GGT>GGG	p.G173G	SFRS18_uc003ppp.3_Silent_p.G173G|SFRS18_uc011eag.1_Silent_p.G173G|SFRS18_uc003ppr.2_Silent_p.G173G	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	173	Pro-rich.					nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)		CTTGCGGTGGACCAAAAGCAG	0.468													3	42					0	0	0.000602	0	0
SIM1	6492	broad.mit.edu	37	6	100841738	100841738	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:100841738C>T	uc003pqj.3	-	10	1402	c.1195G>A	c.(1195-1197)GAA>AAA	p.E399K	SIM1_uc010kcu.2_Missense_Mutation_p.E399K	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	399	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TGATCAGATTCCGATCTTTCT	0.507													4	38					0	0	0.001168	0	0
AIM1	202	broad.mit.edu	37	6	106967774	106967774	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:106967774C>T	uc003prh.2	+	2	1954	c.1467C>T	c.(1465-1467)TTC>TTT	p.F489F		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	489							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TAAGCAGTTTCCCATGCACTG	0.473													21	58					0	0	0.002780	0	0
PPIL6	285755	broad.mit.edu	37	6	109748351	109748351	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:109748351G>A	uc003ptg.3	-	4	483	c.429C>T	c.(427-429)TTC>TTT	p.F143F	PPIL6_uc010kdo.2_Silent_p.F111F|PPIL6_uc010kdp.2_Silent_p.F143F	NM_173672	NP_775943	Q8IXY8	PPIL6_HUMAN	peptidylprolyl isomerase-like 6 isoform 1	143					protein folding		peptidyl-prolyl cis-trans isomerase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.00684)|BRCA - Breast invasive adenocarcinoma(108;0.00889)|all cancers(137;0.0106)|OV - Ovarian serous cystadenocarcinoma(136;0.0259)		CCAAAAACACGAAATCATGCT	0.308													6	32					0	0	0.003080	0	0
SLC22A16	85413	broad.mit.edu	37	6	110763633	110763633	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:110763633G>A	uc003puf.2	-	4	1064	c.997C>T	c.(997-999)CCT>TCT	p.P333S	SLC22A16_uc003pue.2_Missense_Mutation_p.P314S	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	333					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		TTACTAACAGGACCTTGTAGG	0.413													6	59					0	0	0.001984	0	0
RFX6	222546	broad.mit.edu	37	6	117248493	117248493	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:117248493G>A	uc003pxm.2	+	17	2252	c.2189G>A	c.(2188-2190)TGG>TAG	p.W730*		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	730					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TGCATGGCTTGGACTGAACAG	0.547													5	47					0	0	0.000602	0	0
RFX6	222546	broad.mit.edu	37	6	117250065	117250065	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:117250065G>A	uc003pxm.2	+	18	2605	c.2542G>A	c.(2542-2544)GGT>AGT	p.G848S		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	848					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						AGATGACAGTGGTAGAAAACA	0.433													9	54					0	0	0.006214	0	0
ROS1	6098	broad.mit.edu	37	6	117622146	117622146	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:117622146T>A	uc003pxp.1	-	42	6923	c.6724A>T	c.(6724-6726)AGC>TGC	p.S2242C	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2242	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CCTTCAAAGCTTTCATTTATG	0.333			T	GOPC|ROS1	glioblastoma|NSCLC								7	25					0	0	0.003080	0	0
ROS1	6098	broad.mit.edu	37	6	117708132	117708132	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:117708132T>C	uc003pxp.1	-	14	2244	c.2045A>G	c.(2044-2046)AAA>AGA	p.K682R	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	682	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CCCATCTTCTTTCACAGCCAT	0.368			T	GOPC|ROS1	glioblastoma|NSCLC								8	63					0	0	0.006214	0	0
GOPC	57120	broad.mit.edu	37	6	117888030	117888030	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:117888030G>A	uc003pxu.2	-	8	1475	c.1245C>T	c.(1243-1245)ATC>ATT	p.I415I	GOPC_uc003pxq.1_Silent_p.I188I|DCBLD1_uc003pxs.2_Intron|GOPC_uc003pxv.2_Silent_p.I407I	NM_020399	NP_065132	Q9HD26	GOPC_HUMAN	golgi associated PDZ and coiled-coil motif	415					apical protein localization|cytoplasmic sequestering of CFTR protein|ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein homooligomerization|protein transport	cell junction|dendrite|Golgi membrane|postsynaptic density|postsynaptic membrane|trans-Golgi network transport vesicle	cystic fibrosis transmembrane conductance regulator binding			ovary(1)	1		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)		GTAATACTTTGATTTCCCCAC	0.318			O	ROS1	glioblastoma								5	23					0	0	0.001168	0	0
FAM184A	79632	broad.mit.edu	37	6	119301410	119301410	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:119301410C>T	uc003pyj.2	-	10	2542	c.2194G>A	c.(2194-2196)GAG>AAG	p.E732K	FAM184A_uc003pyk.3_Missense_Mutation_p.E612K|FAM184A_uc003pyl.3_Missense_Mutation_p.E612K	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	732	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TCTTCAAGCTCTTGCGTAAGC	0.428													12	49					0	0	0.010729	0	0
C6orf174	387104	broad.mit.edu	37	6	127797475	127797475	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:127797475C>T	uc003qbd.2	-	6	2561	c.1696G>A	c.(1696-1698)GAT>AAT	p.D566N	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	566	Potential.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CTGTCCAGATCCCCATAAAAG	0.502													5	61					0	0	0.000602	0	0
C6orf191	253582	broad.mit.edu	37	6	130164702	130164702	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:130164702G>A	uc003qbs.2	-	3	249	c.166C>T	c.(166-168)CCC>TCC	p.P56S		NM_001010876	NP_001010876	Q5VVB8	CF191_HUMAN	hypothetical protein LOC253582	56						integral to membrane				large_intestine(1)	1				GBM - Glioblastoma multiforme(226;0.0387)|all cancers(137;0.115)|OV - Ovarian serous cystadenocarcinoma(155;0.131)		AGCCATGAGGGATTTGTTTTG	0.308													10	69					0	0	0.001855	0	0
ENPP1	5167	broad.mit.edu	37	6	132176142	132176142	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:132176142C>T	uc011ecf.1	+	6	714	c.694C>T	c.(694-696)CTT>TTT	p.L232F		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	232	Phosphodiesterase.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	GGGTGGACTTCTTCCTGTTAT	0.393													6	54					0	0	0.001984	0	0
TAAR8	83551	broad.mit.edu	37	6	132874774	132874774	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:132874774C>T	uc011ecj.1	+	1	943	c.943C>T	c.(943-945)CCT>TCT	p.P315S		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	315	Cytoplasmic (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		TCTATTTTATCCTTGGTTTAG	0.333													5	83					0	0	0.001168	0	0
TAAR2	9287	broad.mit.edu	37	6	132938398	132938398	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:132938398C>T	uc003qdl.1	-	2	947	c.947G>A	c.(946-948)GGT>GAT	p.G316D	TAAR2_uc010kfr.1_Missense_Mutation_p.G271D	NM_001033080	NP_001028252	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2 isoform 1	316	Helical; Name=7; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		ATAGAAGAAACCATATATTAA	0.348													9	11					0	0	0.008291	0	0
TAAR2	9287	broad.mit.edu	37	6	132939276	132939276	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:132939276G>A	uc003qdl.1	-	2	69	c.69C>T	c.(67-69)TTC>TTT	p.F23F	TAAR2_uc010kfr.1_5'Flank	NM_001033080	NP_001028252	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2 isoform 1	23	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		CAGAGCAATTGAATTTTTCCT	0.323													8	35					0	0	0.008291	0	0
EYA4	2070	broad.mit.edu	37	6	133789852	133789852	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:133789852G>A	uc003qec.3	+	11	1411	c.953G>A	c.(952-954)GGA>GAA	p.G318E	EYA4_uc011ecq.1_Missense_Mutation_p.G264E|EYA4_uc011ecr.1_Missense_Mutation_p.G264E|EYA4_uc003qed.3_Missense_Mutation_p.G318E|EYA4_uc003qee.3_Missense_Mutation_p.G295E|EYA4_uc011ecs.1_Missense_Mutation_p.G318E|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	318					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TCTCTCCCAGGACTGACTAAC	0.408													16	61					0	0	0.007413	0	0
MAP3K5	4217	broad.mit.edu	37	6	137019667	137019667	+	Missense_Mutation	SNP	G	A	A	rs145735047		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:137019667G>A	uc003qhc.2	-	4	1127	c.766C>T	c.(766-768)CGT>TGT	p.R256C	MAP3K5_uc011edk.1_Missense_Mutation_p.R101C|MAP3K5_uc010kgw.1_Missense_Mutation_p.R256C	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	256					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding	p.R256C(1)		ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TGAATAAAACGATCCACAAGA	0.408													4	17					0	0	0.009096	0	0
KIAA1244	57221	broad.mit.edu	37	6	138607888	138607888	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:138607888G>A	uc003qhu.2	+	16	2620	c.2620G>A	c.(2620-2622)GAT>AAT	p.D874N		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	874					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GAACTTGATCGATACTTTATC	0.512													8	92					0	0	0.006214	0	0
ECT2L	345930	broad.mit.edu	37	6	139186178	139186178	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:139186178C>T	uc003qif.1	+	10	1440	c.1337C>T	c.(1336-1338)TCC>TTC	p.S446F	ECT2L_uc011edq.1_Missense_Mutation_p.S377F	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	446					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						GCCCCCTCTTCCATCTACTTC	0.448													4	43					0	0	0.009096	0	0
HIVEP2	3097	broad.mit.edu	37	6	143092446	143092446	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:143092446G>A	uc003qjd.2	-	5	4173	c.3430C>T	c.(3430-3432)CCC>TCC	p.P1144S		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CTCAGCGGGGGACAAGGACCC	0.622													5	43					0	0	0.000602	0	0
PLAGL1	5325	broad.mit.edu	37	6	144262598	144262598	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:144262598G>A	uc003qjv.2	-	3	2621	c.1355C>T	c.(1354-1356)TCT>TTT	p.S452F	PLAGL1_uc003qjx.2_Missense_Mutation_p.S452F|PLAGL1_uc003qjy.2_Missense_Mutation_p.S452F|PLAGL1_uc010khl.2_Missense_Mutation_p.S452F|PLAGL1_uc010khm.2_Missense_Mutation_p.S452F|PLAGL1_uc003qjz.2_Missense_Mutation_p.S452F|PLAGL1_uc003qka.2_Missense_Mutation_p.S452F|PLAGL1_uc003qkb.2_Missense_Mutation_p.S400F|PLAGL1_uc003qkc.2_Missense_Mutation_p.S452F|PLAGL1_uc003qkd.2_Missense_Mutation_p.S400F|PLAGL1_uc003qke.2_Missense_Mutation_p.S452F|PLAGL1_uc003qkf.2_Missense_Mutation_p.S452F|PLAGL1_uc003qkg.2_Missense_Mutation_p.S400F|PLAGL1_uc003qkh.2_Missense_Mutation_p.S452F|PLAGL1_uc003qki.2_Missense_Mutation_p.S400F|PLAGL1_uc003qkj.2_Missense_Mutation_p.S452F|PLAGL1_uc003qkk.2_Missense_Mutation_p.S400F|PLAGL1_uc003qkl.2_Missense_Mutation_p.S400F|PLAGL1_uc003qkm.2_Missense_Mutation_p.S452F|PLAGL1_uc010khn.2_Missense_Mutation_p.S452F|PLAGL1_uc003qkn.2_Missense_Mutation_p.S400F|PLAGL1_uc003qko.2_Missense_Mutation_p.S452F|PLAGL1_uc003qkp.2_Missense_Mutation_p.S400F|PLAGL1_uc003qjw.2_Missense_Mutation_p.S400F	NM_002656	NP_002647	Q9UM63	PLAL1_HUMAN	pleiomorphic adenoma gene-like 1 isoform 1	452					cell cycle arrest|induction of apoptosis|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.74e-07)|GBM - Glioblastoma multiforme(68;0.0885)		CAGGATGGCAGAGCCAGTGCC	0.493													32	309					0	0	0.004878	0	0
IYD	389434	broad.mit.edu	37	6	150690282	150690282	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:150690282G>A	uc003qnu.1	+	1	255	c.115G>A	c.(115-117)GAA>AAA	p.E39K	IYD_uc003qnv.1_Missense_Mutation_p.E39K|IYD_uc003qnw.1_RNA|IYD_uc003qnx.1_Missense_Mutation_p.E39K|IYD_uc010kik.1_5'UTR	NM_203395	NP_981932	Q6PHW0	IYD1_HUMAN	iodotyrosine dehalogenase 1 isoform 2	39	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				ovary(2)	2		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		AACCAGGGCCGAAGCTCGCCC	0.502													12	81					0	0	0.013537	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151054870	151054870	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:151054870C>T	uc003qny.1	+	3	365	c.53C>T	c.(52-54)TCG>TTG	p.S18L	PLEKHG1_uc011eel.1_Missense_Mutation_p.S58L|PLEKHG1_uc011eem.1_Missense_Mutation_p.S77L|PLEKHG1_uc003qnz.2_Missense_Mutation_p.S18L	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	18					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		ACATCATCCTCGGCCTCTTCC	0.547													8	73					0	0	0.003080	0	0
C6orf97	80129	broad.mit.edu	37	6	151917549	151917549	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:151917549A>C	uc003qol.2	+	9	1636	c.1547A>C	c.(1546-1548)GAG>GCG	p.E516A		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	516	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		CAGCTGGAGGAGGAGAAGCAG	0.527													3	39					0	0	0.009096	0	0
ESR1	2099	broad.mit.edu	37	6	152332924	152332924	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:152332924G>A	uc003qom.3	+	7	1600	c.1230G>A	c.(1228-1230)TTG>TTA	p.L410L	ESR1_uc010kin.2_Silent_p.L410L|ESR1_uc010kio.2_Silent_p.L412L|ESR1_uc010kip.2_Silent_p.L409L|ESR1_uc003qon.3_Silent_p.L410L|ESR1_uc003qoo.3_Silent_p.L410L|ESR1_uc010kiq.2_Intron|ESR1_uc010kir.2_Intron|ESR1_uc011eet.1_Intron|ESR1_uc011eeu.1_Intron|ESR1_uc011eev.1_Intron|ESR1_uc011eew.1_Intron|ESR1_uc010kis.2_Silent_p.L79L|ESR1_uc011eex.1_Silent_p.L191L|ESR1_uc010kit.1_Intron|ESR1_uc011eey.1_Silent_p.L147L	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	410	Steroid-binding.|Interaction with AKAP13.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	ACTTGCTCTTGGACAGGTAAG	0.463													4	57					0	0	0.009096	0	0
SYNE1	23345	broad.mit.edu	37	6	152539445	152539445	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:152539445G>A	uc010kiw.2	-	121	22740	c.22138C>T	c.(22138-22140)CCT>TCT	p.P7380S	SYNE1_uc010kiv.2_Missense_Mutation_p.P1904S|SYNE1_uc003qos.3_Missense_Mutation_p.P1904S|SYNE1_uc003qot.3_Missense_Mutation_p.P7309S|SYNE1_uc003qou.3_Missense_Mutation_p.P7380S|SYNE1_uc003qor.3_Missense_Mutation_p.P280S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7380	Spectrin 24.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAGTGGCTAGGGTCCTGCCCT	0.438										HNSCC(10;0.0054)			22	203					0	0	0.014323	0	0
SYNE1	23345	broad.mit.edu	37	6	152652268	152652268	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:152652268G>A	uc010kiw.2	-	78	14154	c.13552C>T	c.(13552-13554)CGC>TGC	p.R4518C	SYNE1_uc003qot.3_Missense_Mutation_p.R4447C|SYNE1_uc003qou.3_Missense_Mutation_p.R4518C|SYNE1_uc010kiz.2_Missense_Mutation_p.R273C	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4518	Cytoplasmic (Potential).|Spectrin 13.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATTAGTTCGCGACCCTGGGCC	0.458										HNSCC(10;0.0054)			8	54					0	0	0.003080	0	0
SYNE1	23345	broad.mit.edu	37	6	152708227	152708227	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:152708227C>T	uc010kiw.2	-	54	9069	c.8467G>A	c.(8467-8469)GAT>AAT	p.D2823N	SYNE1_uc003qot.3_Missense_Mutation_p.D2830N|SYNE1_uc003qou.3_Missense_Mutation_p.D2823N|SYNE1_uc010kjb.1_Missense_Mutation_p.D2806N	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2823	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTCATTATATCATTAAACTGT	0.328										HNSCC(10;0.0054)			4	48					0	0	0.001168	0	0
SYNE1	23345	broad.mit.edu	37	6	152793506	152793506	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:152793506C>T	uc010kiw.2	-	15	1995	c.1393G>A	c.(1393-1395)GAA>AAA	p.E465K	SYNE1_uc003qot.3_Missense_Mutation_p.E472K|SYNE1_uc003qou.3_Missense_Mutation_p.E465K|SYNE1_uc010kjb.1_Missense_Mutation_p.E448K|SYNE1_uc003qpa.1_Missense_Mutation_p.E465K|SYNE1_uc003qox.1_5'UTR|SYNE1_uc003qoz.2_5'UTR|SYNE1_uc003qoy.2_Missense_Mutation_p.E32K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	465	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CGGTAGATTTCATGGAATGCT	0.403										HNSCC(10;0.0054)			7	68					0	0	0.008291	0	0
SYNE1	23345	broad.mit.edu	37	6	152832177	152832177	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:152832177C>T	uc010kiw.2	-	7	973	c.371G>A	c.(370-372)GGA>GAA	p.G124E	SYNE1_uc003qot.3_Missense_Mutation_p.G131E|SYNE1_uc003qou.3_Missense_Mutation_p.G124E|SYNE1_uc010kjb.1_Missense_Mutation_p.G124E|SYNE1_uc003qpa.1_Missense_Mutation_p.G124E	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	124	Actin-binding.|Cytoplasmic (Potential).|CH 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCACATCAATCCAAGAACTAT	0.373										HNSCC(10;0.0054)			17	157					0	0	0.010504	0	0
MYCT1	80177	broad.mit.edu	37	6	153043307	153043307	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:153043307C>T	uc003qpd.3	+	2	635	c.627C>T	c.(625-627)TCC>TCT	p.S209S	MYCT1_uc010kjc.1_Silent_p.S161S|MYCT1_uc003qpc.3_Silent_p.S209S	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	209						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		ACTACTGGTCCAGTAACAGTC	0.527													7	71					0	0	0.003080	0	0
VIP	7432	broad.mit.edu	37	6	153075349	153075349	+	Silent	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:153075349T>A	uc003qpe.2	+	3	328	c.156T>A	c.(154-156)GTT>GTA	p.V52V	VIP_uc003qpf.2_Silent_p.V52V|VIP_uc010kjd.2_Silent_p.V52V	NM_003381	NP_003372	P01282	VIP_HUMAN	vasoactive intestinal peptide isoform 1	52					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity				0		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		CTGATCAAGTTTCATTAAAAG	0.358													9	35					0	0	0.004482	0	0
TIAM2	26230	broad.mit.edu	37	6	155450721	155450721	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:155450721G>A	uc003qqb.2	+	6	1637	c.364G>A	c.(364-366)GAG>AAG	p.E122K	TIAM2_uc003qqe.2_Missense_Mutation_p.E122K	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	122					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGTTGGCCACGAGCTGGCAGA	0.557													7	20					0	0	0.003080	0	0
SYNJ2	8871	broad.mit.edu	37	6	158514070	158514070	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:158514070C>T	uc003qqx.1	+	26	3753	c.3678C>T	c.(3676-3678)CTC>CTT	p.L1226L	SYNJ2_uc003qqw.1_Silent_p.L1226L|SYNJ2_uc003qqy.1_Silent_p.L939L|SYNJ2_uc003qqz.1_Silent_p.L843L|SYNJ2_uc003qra.1_Silent_p.L569L|SYNJ2_uc010kjp.1_Silent_p.L109L	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1226	Catalytic (By similarity).|Pro-rich.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CGCCCCCACTCCTTCCCCGTC	0.587													4	19					0	0	0.009096	0	0
SERAC1	84947	broad.mit.edu	37	6	158549146	158549146	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:158549146G>A	uc003qrc.2	-	10	1151	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C	SERAC1_uc003qrb.2_Missense_Mutation_p.R65C	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	337					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		TTACCTGAGCGAACTATAGAA	0.333													8	39					0	0	0.004482	0	0
TAGAP	117289	broad.mit.edu	37	6	159463166	159463166	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:159463166C>T	uc003qrz.2	-	5	591	c.259G>A	c.(259-261)GAT>AAT	p.D87N	TAGAP_uc011eft.1_Missense_Mutation_p.D24N|TAGAP_uc003qsa.2_Intron|TAGAP_uc003qsb.2_Missense_Mutation_p.D87N|uc003qsc.2_5'Flank	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	87					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		AAGGGCTGATCAAATAGCGAT	0.493													12	168					0	0	0.010729	0	0
TAGAP	117289	broad.mit.edu	37	6	159463277	159463277	+	Splice_Site	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:159463277C>T	uc003qrz.2	-	5	481	c.149_splice	c.e5-1	p.E50_splice	TAGAP_uc011eft.1_5'UTR|TAGAP_uc003qsa.2_Intron|TAGAP_uc003qsb.2_Splice_Site_p.E50_splice|uc003qsc.2_5'Flank	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TTCTTAACTTCTACAGCCAAG	0.448													19	90					0	0	0.012319	0	0
FNDC1	84624	broad.mit.edu	37	6	159682253	159682253	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:159682253C>T	uc010kjv.2	+	19	5406	c.5206C>T	c.(5206-5208)CAT>TAT	p.H1736Y		NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1736	Fibronectin type-III 5.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		ACAAAATCCTCATGGCTACGG	0.358													9	58					0	0	0.008291	0	0
IGF2R	3482	broad.mit.edu	37	6	160430071	160430072	+	Missense_Mutation	DNP	TC	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:160430071_160430072TC>AA	uc003qta.2	+	3	467_468	c.319_320TC>AA	c.(319-321)TCT>AAT	p.S107N		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	107	1.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TGCAACCAGATCTCTCCTGGAA	0.446													9	46					0	0	0.004672	0	0
LPAL2	80350	broad.mit.edu	37	6	160906919	160906919	+	RNA	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:160906919C>T	uc003qtj.2	-	5		c.778G>A			LPAL2_uc011efy.1_RNA	NR_028093				Homo sapiens cDNA FLJ43922 fis, clone TESTI4012406.												0		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		GCAAGTGCTTCCTGTGACGGT	0.453													19	176					0	0	0.006122	0	0
LPA	4018	broad.mit.edu	37	6	160977125	160977125	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:160977125C>T	uc003qtl.2	-	31	5025	c.4905G>A	c.(4903-4905)AGG>AGA	p.R1635R		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4143	Kringle 37.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ATTGACATGTCCTTCCTGTGA	0.488													14	53					0	0	0.004990	0	0
PLG	5340	broad.mit.edu	37	6	161127561	161127561	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:161127561G>A	uc003qtm.3	+	2	235	c.172G>A	c.(172-174)GAA>AAA	p.E58K		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	58	PAN.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGAGGACGAAGAATTCACCTG	0.423													14	57					0	0	0.002450	0	0
PLG	5340	broad.mit.edu	37	6	161134069	161134069	+	Silent	SNP	G	A	A	rs144153702	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:161134069G>A	uc003qtm.3	+	5	522	c.459G>A	c.(457-459)AGG>AGA	p.R153R		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	153	Kringle 1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ACTACTGCAGGAATCCAGACA	0.483													9	79					0	0	0.004482	0	0
MAP3K4	4216	broad.mit.edu	37	6	161508729	161508729	+	Missense_Mutation	SNP	C	T	T	rs143918593		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:161508729C>T	uc003qtn.2	+	10	2708	c.2566C>T	c.(2566-2568)CCT>TCT	p.P856S	MAP3K4_uc010kkc.1_Missense_Mutation_p.P856S|MAP3K4_uc003qto.2_Missense_Mutation_p.P856S|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.P309S	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	856					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GGTGCAAATTCCTGGGTTAGA	0.383													9	45					0	0	0.004482	0	0
PARK2	5071	broad.mit.edu	37	6	162622220	162622220	+	Silent	SNP	C	T	T	rs146547001		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:162622220C>T	uc003qtx.3	-	4	611	c.477G>A	c.(475-477)CCG>CCA	p.P159P	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_5'UTR|PARK2_uc003qtw.3_Intron|PARK2_uc003qty.3_Silent_p.P159P|PARK2_uc003qtz.3_Intron|PARK2_uc010kke.1_Silent_p.P159P	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	159					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TGAGTTTTCCCGGCTGCACTC	0.483													7	55					0	0	0.001984	0	0
C6orf118	168090	broad.mit.edu	37	6	165715342	165715342	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:165715342C>T	uc003qum.3	-	2	505	c.469G>A	c.(469-471)GAA>AAA	p.E157K	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	157											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TTCTTTTCTTCCTTCCCCTCT	0.612													20	36					0	0	0.008871	0	0
T	6862	broad.mit.edu	37	6	166580938	166580938	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:166580938C>G	uc003quu.1	-	2	635	c.142G>C	c.(142-144)GAG>CAG	p.E48Q	T_uc003qut.1_Missense_Mutation_p.E48Q|T_uc003quv.1_Missense_Mutation_p.E48Q	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	48					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		AGCTCGCTCTCCTCCAGGCCC	0.682									Chordoma_Familial_Clustering_of				3	22					0	0	0.000602	0	0
CCR6	1235	broad.mit.edu	37	6	167550192	167550192	+	Silent	SNP	C	T	T	rs111874598		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:167550192C>T	uc003qvl.2	+	13	2950	c.474C>T	c.(472-474)TCC>TCT	p.S158S	CCR6_uc010kkm.2_Silent_p.S158S|CCR6_uc003qvn.3_Silent_p.S158S|CCR6_uc003qvm.3_Silent_p.S158S	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	158	Cytoplasmic (Potential).				cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		GGCTCCGATCCAGAACACTAC	0.498													6	52					0	0	0.001984	0	0
UNC93A	54346	broad.mit.edu	37	6	167708163	167708163	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:167708163C>T	uc003qvq.2	+	2	421	c.246C>T	c.(244-246)TCC>TCT	p.S82S	UNC93A_uc003qvr.2_Silent_p.S82S	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	82	Helical; (Potential).					integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TGGCCTTCTCCGTGGGCAACT	0.637													11	102					0	0	0.001855	0	0
KIF25	3834	broad.mit.edu	37	6	168445543	168445543	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:168445543C>T	uc003qwk.1	+	9	1284	c.1022C>T	c.(1021-1023)TCT>TTT	p.S341F	KIF25_uc003qwl.1_Missense_Mutation_p.S289F	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	341					microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CTCTGCATTTCTCCCAGCCAG	0.552													14	78					0	0	0.002450	0	0
THBS2	7058	broad.mit.edu	37	6	169623560	169623560	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:169623560C>T	uc003qwt.2	-	19	3032	c.2784G>A	c.(2782-2784)CGG>CGA	p.R928R		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	928	TSP type-3 8.|Cell attachment site (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		AAATATCACCCCGTCCATCAC	0.383													4	47					0	0	0.000602	0	0
HEATR2	54919	broad.mit.edu	37	7	825182	825183	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:825182_825183CC>TT	uc010krz.1	+	13	2480_2481	c.2460_2461CC>TT	c.(2458-2463)TTCCCA>TTTTCA	p.P821S	HEATR2_uc003siz.2_Missense_Mutation_p.P689S|HEATR2_uc003sjb.2_Missense_Mutation_p.P201S|HEATR2_uc003sjc.2_Missense_Mutation_p.P246S	NM_017802	NP_060272	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	821	HEAT 10.						protein binding			skin(1)	1		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		GCGGGCTGTTCCCAGATCTCCT	0.554													26	79					0	0	0.004672	0	0
SUN1	23353	broad.mit.edu	37	7	893212	893212	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:893212C>T	uc011jvp.1	+	11	1299	c.1220C>T	c.(1219-1221)CCG>CTG	p.P407L	GET4_uc003sjj.1_RNA|SUN1_uc003sjf.2_Missense_Mutation_p.P324L|SUN1_uc011jvq.1_Missense_Mutation_p.P304L|SUN1_uc003sjg.2_Missense_Mutation_p.P312L|SUN1_uc011jvr.1_Missense_Mutation_p.P216L|SUN1_uc003sji.2_Missense_Mutation_p.P245L|SUN1_uc003sjk.2_Missense_Mutation_p.P46L	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	434	Perinuclear space.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GCTGCCGGGCCGTCAGCTTCG	0.652													6	31					0	0	0.001168	0	0
MAD1L1	8379	broad.mit.edu	37	7	2108921	2108921	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:2108921C>T	uc003slh.1	-	12	1392	c.1126G>A	c.(1126-1128)GTC>ATC	p.V376I	MAD1L1_uc003sle.1_Missense_Mutation_p.V105I|MAD1L1_uc003slf.1_Missense_Mutation_p.V376I|MAD1L1_uc003slg.1_Missense_Mutation_p.V376I|MAD1L1_uc010ksh.1_Missense_Mutation_p.V376I|MAD1L1_uc003sli.1_Missense_Mutation_p.V284I|MAD1L1_uc010ksi.1_Missense_Mutation_p.V329I|MAD1L1_uc010ksj.2_Missense_Mutation_p.V376I	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	376	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TGGCCGCTGACCTGCCGGAGC	0.652													4	23					0	0	0.009096	0	0
CHST12	55501	broad.mit.edu	37	7	2472340	2472340	+	Silent	SNP	C	T	T	rs150285273		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:2472340C>T	uc003smc.2	+	2	201	c.66C>T	c.(64-66)ATC>ATT	p.I22I	CHST12_uc003smd.2_Silent_p.I22I	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	22	Helical; Signal-anchor for type II membrane protein; (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		TCCTGCTGATCATCGTGTACT	0.701													13	55					0	0	0.001855	0	0
CHST12	55501	broad.mit.edu	37	7	2472616	2472616	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:2472616C>T	uc003smc.2	+	2	477	c.342C>T	c.(340-342)AGC>AGT	p.S114S	CHST12_uc003smd.2_Silent_p.S114S	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	114	Lumenal (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CCCGGCGCAGCCCAGACCAGG	0.721													11	29					0	0	0.013537	0	0
CARD11	84433	broad.mit.edu	37	7	2985562	2985562	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:2985562C>T	uc003smv.2	-	4	653	c.249G>A	c.(247-249)AAG>AAA	p.K83K		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	83	CARD.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CCCTTTGCCCCTTGGTATGTA	0.488			Mis		DLBCL								17	172					0	0	0.006122	0	0
SDK1	221935	broad.mit.edu	37	7	4152925	4152925	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:4152925C>T	uc003smx.2	+	24	3578	c.3439C>T	c.(3439-3441)CGA>TGA	p.R1147*	SDK1_uc010kso.2_Nonsense_Mutation_p.R423*	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1147	Fibronectin type-III 5.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CTTTAGATTTCGAATGAAGCA	0.537													39	181					0	0	0.009718	0	0
SDK1	221935	broad.mit.edu	37	7	4215446	4215446	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:4215446C>T	uc003smx.2	+	34	5115	c.4976C>T	c.(4975-4977)TCG>TTG	p.S1659L	SDK1_uc010kso.2_Intron|SDK1_uc003smy.2_Missense_Mutation_p.S146L	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1659	Fibronectin type-III 10.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGCTCCACATCGACGATGTGT	0.587													6	59					0	0	0.001984	0	0
RADIL	55698	broad.mit.edu	37	7	4839071	4839071	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:4839071G>A	uc003snj.1	-	15	3339	c.3166C>T	c.(3166-3168)CTG>TTG	p.L1056L	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Silent_p.L561L|RADIL_uc011jwc.1_Silent_p.L816L|RADIL_uc011jwd.1_RNA|RADIL_uc003snh.1_Silent_p.L352L	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	1056	PDZ.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		TTCGCGACCAGGAACCGCATC	0.652													4	53					0	0	0.009096	0	0
FSCN1	6624	broad.mit.edu	37	7	5632737	5632737	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:5632737G>A	uc003sou.2	+	1	284	c.170G>A	c.(169-171)AGC>AAC	p.S57N		NM_003088	NP_003079	Q16658	FSCN1_HUMAN	fascin 1	57					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			ovary(1)	1		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		GAGGCGGGCAGCGCGGCCGTG	0.706													3	16					0	0	0.009096	0	0
PMS2	5395	broad.mit.edu	37	7	6026496	6026496	+	Missense_Mutation	SNP	G	A	A	rs144489994		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:6026496G>A	uc003spl.2	-	11	1987	c.1900C>T	c.(1900-1902)CAT>TAT	p.H634Y	PMS2_uc003spj.2_Missense_Mutation_p.H528Y|PMS2_uc003spk.2_Missense_Mutation_p.H499Y|PMS2_uc011jwl.1_Missense_Mutation_p.H499Y|PMS2_uc010ktg.2_Missense_Mutation_p.H323Y|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Intron	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	634					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		TGTGCTTCATGATGTAACTGC	0.398			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				15	85					0	0	0.004007	0	0
CYTH3	9265	broad.mit.edu	37	7	6213339	6213339	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:6213339G>A	uc003spt.2	-	6	498	c.394C>T	c.(394-396)CAA>TAA	p.Q132*	CYTH3_uc011jws.1_5'Flank	NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3	132	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						ACAAAGGCTTGAAGAACTTTA	0.368													13	33					0	0	0.013537	0	0
ZDHHC4	55146	broad.mit.edu	37	7	6622969	6622969	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:6622969C>T	uc003sqi.2	+	7	761	c.403C>T	c.(403-405)CTT>TTT	p.L135F	ZDHHC4_uc003sqg.2_Missense_Mutation_p.L135F|ZDHHC4_uc003sql.2_Missense_Mutation_p.L135F|ZDHHC4_uc003sqh.2_Missense_Mutation_p.L135F|ZDHHC4_uc003sqj.2_Missense_Mutation_p.L135F|ZDHHC4_uc003sqk.2_Missense_Mutation_p.L135F|ZDHHC4_uc003sqm.2_Missense_Mutation_p.L135F	NM_001134388	NP_001127860	Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	135						integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|pancreas(1)	2		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		ATTATTATTTCTTCATGTTTA	0.388													12	41					0	0	0.013537	0	0
ICA1	3382	broad.mit.edu	37	7	8198255	8198255	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:8198255T>A	uc003srm.2	-	7	674	c.607A>T	c.(607-609)AAA>TAA	p.K203*	ICA1_uc010ktr.2_Nonsense_Mutation_p.K203*|ICA1_uc003srl.2_Nonsense_Mutation_p.K191*|ICA1_uc003srn.3_Nonsense_Mutation_p.K129*|ICA1_uc003srp.3_Nonsense_Mutation_p.K202*|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Nonsense_Mutation_p.K203*|ICA1_uc003srr.2_Nonsense_Mutation_p.K202*|ICA1_uc003sro.3_Nonsense_Mutation_p.K203*|ICA1_uc011jxg.1_Nonsense_Mutation_p.K203*|ICA1_uc003srs.1_Nonsense_Mutation_p.K203*	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	203	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TCAAAGTTTTTTTTTGCAAGG	0.388													5	37					0	0	0.000602	0	0
BZW2	28969	broad.mit.edu	37	7	16729434	16729434	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:16729434C>T	uc003stl.2	+	7	732	c.554C>T	c.(553-555)TCA>TTA	p.S185L	BZW2_uc011jxx.1_5'UTR|BZW2_uc003stm.2_5'UTR|BZW2_uc003stj.2_Missense_Mutation_p.S185L|BZW2_uc003stk.2_Missense_Mutation_p.S109L|BZW2_uc003sto.1_Missense_Mutation_p.S33L|BZW2_uc003stp.2_Missense_Mutation_p.S33L|BZW2_uc010kua.2_Missense_Mutation_p.S185L	NM_001159767	NP_001153239	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2	185					cell differentiation|nervous system development|RNA metabolic process		protein binding			ovary(2)	2	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		ATTGCGGCCTCATTTGCTGTC	0.418													4	27					0	0	0.009096	0	0
HDAC9	9734	broad.mit.edu	37	7	18631231	18631231	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:18631231C>T	uc003suh.2	+	4	540	c.499C>T	c.(499-501)CAT>TAT	p.H167Y	HDAC9_uc003sue.2_Missense_Mutation_p.H167Y|HDAC9_uc011jyd.1_Missense_Mutation_p.H167Y|HDAC9_uc003sui.2_Missense_Mutation_p.H170Y|HDAC9_uc003suj.2_Missense_Mutation_p.H170Y|HDAC9_uc011jya.1_Missense_Mutation_p.H208Y|HDAC9_uc003sua.1_Missense_Mutation_p.H189Y|HDAC9_uc011jyb.1_Missense_Mutation_p.H167Y|HDAC9_uc003sud.1_Missense_Mutation_p.H167Y|HDAC9_uc011jyc.1_Missense_Mutation_p.H170Y|HDAC9_uc003suf.1_Missense_Mutation_p.H198Y|HDAC9_uc010kud.1_Missense_Mutation_p.H170Y|HDAC9_uc011jye.1_Missense_Mutation_p.H139Y|HDAC9_uc011jyf.1_Missense_Mutation_p.H136Y|HDAC9_uc010kue.1_5'UTR	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	167					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TGGAAAAAATCATTCCGTGAG	0.383													7	48					0	0	0.006214	0	0
HDAC9	9734	broad.mit.edu	37	7	18688097	18688097	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:18688097C>T	uc003suh.2	+	10	1290	c.1249C>T	c.(1249-1251)CCC>TCC	p.P417S	HDAC9_uc003sue.2_Missense_Mutation_p.P417S|HDAC9_uc011jyd.1_Missense_Mutation_p.P417S|HDAC9_uc003sui.2_Missense_Mutation_p.P420S|HDAC9_uc003suj.2_Missense_Mutation_p.P376S|HDAC9_uc011jya.1_Missense_Mutation_p.P414S|HDAC9_uc003sua.1_Missense_Mutation_p.P395S|HDAC9_uc011jyb.1_Missense_Mutation_p.P373S|HDAC9_uc003sud.1_Missense_Mutation_p.P417S|HDAC9_uc011jyc.1_Missense_Mutation_p.P376S|HDAC9_uc003suf.1_Missense_Mutation_p.P448S|HDAC9_uc010kud.1_Missense_Mutation_p.P420S|HDAC9_uc011jye.1_Missense_Mutation_p.P389S|HDAC9_uc011jyf.1_Missense_Mutation_p.P340S|HDAC9_uc010kue.1_Missense_Mutation_p.P160S	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	417					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	AGGTGGAGTTCCCTTACATCC	0.343													14	41					0	0	0.002450	0	0
TMEM196	256130	broad.mit.edu	37	7	19765251	19765251	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:19765251G>A	uc011jyg.1	-	3	430	c.345C>T	c.(343-345)ATC>ATT	p.I115I	TMEM196_uc003sur.2_RNA	NM_152774	NP_689987	Q5HYL7	TM196_HUMAN	transmembrane protein 196	121	Helical; (Potential).					integral to membrane					0						TGCAGCCCCCGATCCCAATGC	0.532													10	44					0	0	0.010729	0	0
ABCB5	340273	broad.mit.edu	37	7	20738148	20738148	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:20738148C>T	uc003suw.3	+	8	1340	c.794C>T	c.(793-795)TCC>TTC	p.S265F	ABCB5_uc010kuh.2_Missense_Mutation_p.S710F	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	265	Helical; (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CCAGTATTTTCCATCATCTTT	0.323													5	29					0	0	0.000602	0	0
DNAH11	8701	broad.mit.edu	37	7	21609915	21609915	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:21609915G>C	uc003svc.2	+	7	1454	c.1423G>C	c.(1423-1425)GAG>CAG	p.E475Q		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	475	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AATAAAAATAGAGGTATTCAT	0.348									Kartagener_syndrome				3	50					0	0	0.004672	0	0
DNAH11	8701	broad.mit.edu	37	7	21657383	21657383	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:21657383G>A	uc003svc.2	+	23	4288	c.4257G>A	c.(4255-4257)ATG>ATA	p.M1419I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1419	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ACCAGCTGATGAAAGCTATTG	0.488									Kartagener_syndrome				4	29					0	0	0.000602	0	0
DNAH11	8701	broad.mit.edu	37	7	21695476	21695476	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:21695476C>T	uc003svc.2	+	29	5017	c.4986C>T	c.(4984-4986)TTC>TTT	p.F1662F		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1662	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CCAAACTTTTCGACAGCATTG	0.383									Kartagener_syndrome				4	29					0	0	0.009096	0	0
KLHL7	55975	broad.mit.edu	37	7	23183560	23183560	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:23183560C>T	uc003svs.3	+	6	1002	c.709C>T	c.(709-711)CTT>TTT	p.L237F	KLHL7_uc003svr.3_Missense_Mutation_p.L215F|KLHL7_uc011jys.1_Missense_Mutation_p.L161F|KLHL7_uc011jyt.1_Missense_Mutation_p.L12F|KLHL7_uc003svt.2_Missense_Mutation_p.L189F|KLHL7_uc011jyv.1_Missense_Mutation_p.L12F	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	237						Golgi apparatus|nucleolus|plasma membrane					0						CAGGTTTCCTCTTATATCAAA	0.383													7	87					0	0	0.001984	0	0
LOC402644	402644	broad.mit.edu	37	7	28319219	28319219	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:28319219C>T	uc010kuz.1	-	1	100	c.100G>A	c.(100-102)GAA>AAA	p.E34K		NM_001126493	NP_001119965			hypothetical protein LOC402644												0						CGAACGTTTTCTGCTGTCTTT	0.468													6	41					0	0	0.001168	0	0
CRHR2	1395	broad.mit.edu	37	7	30721873	30721873	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:30721873G>A	uc003tbn.2	-	1	268	c.24C>T	c.(22-24)AGC>AGT	p.S8S	CRHR2_uc010kvw.1_Silent_p.S8S|CRHR2_uc010kvx.1_Silent_p.S8S|CRHR2_uc010kvy.1_5'UTR|CRHR2_uc003tbo.2_Intron|CRHR2_uc003tbp.2_Intron|CRHR2_uc010kvz.1_Intron|CRHR2_uc003tbq.1_Intron|CRHR2_uc003tbr.1_RNA|CRHR2_uc010kwa.1_Missense_Mutation_p.A87V	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	8					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						CCTCCAGCAGGCTGTGGAGCA	0.726													3	4					0	0	0.004672	0	0
FAM188B	84182	broad.mit.edu	37	7	30876318	30876318	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:30876318C>T	uc003tbt.2	+	7	1254	c.1177C>T	c.(1177-1179)CCA>TCA	p.P393S	FAM188B_uc010kwe.2_Missense_Mutation_p.P364S	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	393											0						CATCCTGTCGCCAGTCCCATC	0.473													21	115					0	0	0.003954	0	0
C7orf16	10842	broad.mit.edu	37	7	31735191	31735191	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:31735191G>A	uc003tcl.2	+	3	349	c.191G>A	c.(190-192)AGG>AAG	p.R64K	C7orf16_uc011kaf.1_Intron	NM_006658	NP_006649	O96001	GSUB_HUMAN	G-substrate isoform 1	64					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction				ovary(2)|central_nervous_system(1)	3			GBM - Glioblastoma multiforme(11;0.216)			AAAAAACCAAGGAGGAAAGAT	0.458													11	94					0	0	0.010729	0	0
ANLN	54443	broad.mit.edu	37	7	36446171	36446171	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:36446171C>T	uc003tff.2	+	4	1073	c.869C>T	c.(868-870)TCT>TTT	p.S290F	ANLN_uc011kaz.1_Missense_Mutation_p.S202F|ANLN_uc003tfg.2_Missense_Mutation_p.S290F|ANLN_uc010kxe.2_Missense_Mutation_p.S290F	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	290	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						ATTTCCAGCTCTGTGGTAAGT	0.428													10	165					0	0	0.010729	0	0
AOAH	313	broad.mit.edu	37	7	36677509	36677509	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:36677509C>T	uc003tfh.3	-	5	799	c.398G>A	c.(397-399)TGG>TAG	p.W133*	AOAH_uc010kxf.2_Nonsense_Mutation_p.W133*|AOAH_uc011kba.1_Nonsense_Mutation_p.W101*	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	133					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						TGTAAATTTCCATGTCTCCTA	0.363													4	22					0	0	0.009096	0	0
ELMO1	9844	broad.mit.edu	37	7	36917698	36917698	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:36917698G>A	uc003tfk.1	-	19	2046	c.1739C>T	c.(1738-1740)TCG>TTG	p.S580L	ELMO1_uc003tfi.1_Missense_Mutation_p.S100L|ELMO1_uc003tfj.1_Missense_Mutation_p.S100L|ELMO1_uc011kbb.1_RNA|ELMO1_uc011kbc.1_Missense_Mutation_p.S484L|ELMO1_uc010kxg.1_Missense_Mutation_p.S580L	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	580	PH.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GTGATTTGGCGAAAGCCGACA	0.418													6	37					0	0	0.003080	0	0
TXNDC3	51314	broad.mit.edu	37	7	37936490	37936490	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:37936490G>A	uc003tfn.2	+	17	1935	c.1563G>A	c.(1561-1563)ATG>ATA	p.M521I		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	521	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						CTATGGTCATGATTCTGACCA	0.488									Kartagener_syndrome				26	64					0	0	0.010818	0	0
SFRP4	6424	broad.mit.edu	37	7	37947220	37947220	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:37947220T>G	uc003tfo.3	-	6	1288	c.902A>C	c.(901-903)AAG>ACG	p.K301T		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	301	NTR.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						TGTTTTCTTCTTGTCCTGAAC	0.488													3	81					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	7	38288965	38288965	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:38288965C>T	uc003tfu.3	-	2	259	c.24G>A	c.(22-24)ATG>ATA	p.M8I	uc003tfv.2_Missense_Mutation_p.M8I|uc003tfw.2_RNA|uc003tfx.1_RNA|uc003tfz.1_RNA					SubName: Full=TARP protein;																		AGCTAAATTTCATGTATGTGT	0.388													14	156					0	0	0.001855	0	0
Unknown	0	broad.mit.edu	37	7	38370155	38370155	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:38370155G>A	uc010kxj.1	-	2	279	c.143C>T	c.(142-144)GCC>GTC	p.A48V	uc010kxk.1_RNA					SubName: Full=Putative uncharacterized protein ENSP00000374866;																		GGTGTAGACGGCATTTTCTAC	0.502													7	46					0	0	0.003080	0	0
AMPH	273	broad.mit.edu	37	7	38433676	38433676	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:38433676C>T	uc003tgu.2	-	18	1606	c.1537G>A	c.(1537-1539)GGA>AGA	p.G513R	AMPH_uc003tgv.2_Missense_Mutation_p.G471R|AMPH_uc003tgt.2_Missense_Mutation_p.G398R|AMPH_uc003tgw.1_Missense_Mutation_p.G536R|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	513					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						GTTTCAGTTCCAATTTTGGCC	0.597													18	111					0	0	0.007413	0	0
AMPH	273	broad.mit.edu	37	7	38534086	38534086	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:38534086C>T	uc003tgu.2	-	4	316	c.247G>A	c.(247-249)GAA>AAA	p.E83K	AMPH_uc003tgv.2_Missense_Mutation_p.E83K	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	83	BAR.|Potential.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TCATAGACTTCATGCAGCGAC	0.532													15	128					0	0	0.002450	0	0
MYO1G	64005	broad.mit.edu	37	7	45014788	45014788	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:45014788G>A	uc003tmh.2	-	5	747	c.603C>T	c.(601-603)TTC>TTT	p.F201F	MYO1G_uc003tmg.2_5'UTR|MYO1G_uc010kym.2_Silent_p.F86F|MYO1G_uc003tmi.1_Silent_p.F113F|MYO1G_uc003tmj.2_5'UTR	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	201	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						AGAAGGCGTGGAAGTTTCTTT	0.597													19	235					0	0	0.012319	0	0
RAMP3	10268	broad.mit.edu	37	7	45222924	45222924	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:45222924C>T	uc003tnb.2	+	3	421	c.360C>T	c.(358-360)ATC>ATT	p.I120I	RAMP3_uc003tnc.2_Silent_p.I88I	NM_005856	NP_005847	O60896	RAMP3_HUMAN	receptor activity modifying protein 3 precursor	120	Helical; (Potential).				intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane|lysosome	protein transporter activity				0					Pramlintide(DB01278)	AGGTTCTCATCCCGCTGATCG	0.632													6	125					0	0	0.001984	0	0
ABCA13	154664	broad.mit.edu	37	7	48349707	48349707	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:48349707G>A	uc003toq.2	+	24	9510	c.9485G>A	c.(9484-9486)CGA>CAA	p.R3162Q	ABCA13_uc010kys.1_Missense_Mutation_p.R236Q|ABCA13_uc003tos.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3162					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTGCTGAGTCGAAACTTGGAT	0.507													31	203					0	0	0.004878	0	0
POM121L12	285877	broad.mit.edu	37	7	53103816	53103816	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:53103816G>A	uc003tpz.2	+	1	468	c.452G>A	c.(451-453)TGG>TAG	p.W151*		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	151											0						GAGAGCCCCTGGAGATCCCCT	0.587													4	17					0	0	0.009096	0	0
EGFR	1956	broad.mit.edu	37	7	55238901	55238901	+	Silent	SNP	G	A	A	rs146783627	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:55238901G>A	uc003tqk.2	+	16	2160	c.1914G>A	c.(1912-1914)ACG>ACA	p.T638T	EGFR_uc010kzg.1_Silent_p.T593T|EGFR_uc011kco.1_Silent_p.T585T|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	638	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GCTGTCCAACGAATGGGTAAG	0.443		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			11	54					0	0	0.013537	0	0
EGFR	1956	broad.mit.edu	37	7	55249165	55249165	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:55249165C>T	uc003tqk.2	+	20	2709	c.2463C>T	c.(2461-2463)ATC>ATT	p.I821I	EGFR_uc010kzg.1_Silent_p.I776I|EGFR_uc011kco.1_Silent_p.I768I|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	821	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.I821T(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGTGCAGATCGCAAAGGTAA	0.557		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			14	52					0	0	0.002450	0	0
SUMF2	25870	broad.mit.edu	37	7	56136241	56136241	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:56136241C>T	uc003trv.2	+	2	222	c.191C>T	c.(190-192)CCA>CTA	p.P64L	PSPH_uc003trj.2_Intron|SUMF2_uc003tro.2_Missense_Mutation_p.P64L|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_Missense_Mutation_p.P64L|SUMF2_uc011kcx.1_Missense_Mutation_p.P64L|SUMF2_uc003trt.2_Intron|SUMF2_uc011kcy.1_Missense_Mutation_p.P64L|SUMF2_uc011kcz.1_Missense_Mutation_p.P64L|SUMF2_uc003tru.2_RNA|SUMF2_uc011kda.1_5'UTR|SUMF2_uc003trx.2_RNA	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	45						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ACAAATTCTCCAGACAGCAGA	0.488													12	19					0	0	0.001855	0	0
KCTD7	154881	broad.mit.edu	37	7	66103274	66103274	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:66103274C>T	uc003tve.2	+	3	511	c.349C>T	c.(349-351)CCA>TCA	p.P117S	RABGEF1_uc003tvf.2_5'UTR|KCTD7_uc003tvd.3_Missense_Mutation_p.P117S	NM_153033	NP_694578	Q96MP8	KCTD7_HUMAN	potassium channel tetramerisation domain	117	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)	3						AGGGGACCTCCCACCCAGGGA	0.587													18	71					0	0	0.004990	0	0
KCTD7	154881	broad.mit.edu	37	7	66104169	66104169	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:66104169C>T	uc003tve.2	+	4	982	c.820C>T	c.(820-822)CAC>TAC	p.H274Y	RABGEF1_uc003tvf.2_Intron|KCTD7_uc003tvd.3_Missense_Mutation_p.H274Y	NM_153033	NP_694578	Q96MP8	KCTD7_HUMAN	potassium channel tetramerisation domain	274						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)	3						CCTCGTGAACCACTACTACTG	0.582													7	59					0	0	0.003080	0	0
RABGEF1	27342	broad.mit.edu	37	7	66240307	66240307	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:66240307C>T	uc011kee.1	+	3	479	c.315C>T	c.(313-315)ACC>ACT	p.T105T	RABGEF1_uc003tvf.2_5'UTR|RABGEF1_uc003tvg.2_5'UTR|RABGEF1_uc010lag.2_Silent_p.T91T|RABGEF1_uc003tvh.2_Silent_p.T91T|RABGEF1_uc003tvi.2_5'UTR	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	269					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						AAAAGAAAACCAACGAGAAGA	0.473													11	33					0	0	0.008291	0	0
WBSCR17	64409	broad.mit.edu	37	7	71036359	71036359	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:71036359G>A	uc003tvy.2	+	6	1052	c.1052G>A	c.(1051-1053)GGA>GAA	p.G351E	WBSCR17_uc003tvz.2_Missense_Mutation_p.G50E	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	351	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GATGTATACGGAGGAGAAAAT	0.522													27	74					0	0	0.007291	0	0
POM121	9883	broad.mit.edu	37	7	72400635	72400635	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:72400635C>T	uc003twk.2	+	5	1261	c.1261C>T	c.(1261-1263)CGA>TGA	p.R421*	POM121_uc003twj.2_Nonsense_Mutation_p.R156*|POM121_uc010lam.1_Nonsense_Mutation_p.R156*	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	421	Ser-rich.|Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				CAGCTCCACTCGAGGCATCTC	0.453													39	155					0	0	0.008740	0	0
NSUN5	55695	broad.mit.edu	37	7	72718364	72718364	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:72718364G>A	uc003txw.2	-	7	833	c.797C>T	c.(796-798)TCC>TTC	p.S266F	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Missense_Mutation_p.S266F|NSUN5_uc003txx.2_Missense_Mutation_p.S228F|NSUN5_uc011kev.1_Missense_Mutation_p.S266F	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	266							methyltransferase activity				0		Lung NSC(55;0.163)				CGTGGCCATGGATGCCAGCCG	0.627													7	36					0	0	0.003080	0	0
FKBP6	8468	broad.mit.edu	37	7	72745747	72745747	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:72745747C>T	uc003tya.2	+	5	688	c.556C>T	c.(556-558)CGT>TGT	p.R186C	FKBP6_uc003twz.2_Missense_Mutation_p.R156C|FKBP6_uc011kew.1_Missense_Mutation_p.R181C|FKBP6_uc010lbe.1_RNA	NM_003602	NP_003593	O75344	FKBP6_HUMAN	FK506 binding protein 6 isoform a	186	TPR 1.				protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CCGCCAGAATCGTTTCTATGA	0.423													19	75					0	0	0.012319	0	0
ELN	2006	broad.mit.edu	37	7	73455557	73455557	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:73455557C>T	uc003tzw.2	+	5	299	c.208C>T	c.(208-210)CTT>TTT	p.L70F	RFC2_uc011kfa.1_Intron|ELN_uc003tzm.1_RNA|ELN_uc011kfe.1_Missense_Mutation_p.L70F|ELN_uc003tzn.2_Missense_Mutation_p.L70F|ELN_uc003tzz.2_Intron|ELN_uc003tzo.2_Missense_Mutation_p.L70F|ELN_uc003tzp.2_Missense_Mutation_p.L60F|ELN_uc003tzq.2_Missense_Mutation_p.L70F|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_Missense_Mutation_p.L70F|ELN_uc003tzt.2_Missense_Mutation_p.L70F|ELN_uc003tzu.2_Missense_Mutation_p.L70F|ELN_uc003tzv.2_Missense_Mutation_p.L60F|ELN_uc003tzx.2_Missense_Mutation_p.L60F|ELN_uc011kff.1_Missense_Mutation_p.L70F|ELN_uc003tzy.2_Missense_Mutation_p.L60F	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	70					blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TCCCGGAGGGCTTGCGGGTGC	0.582			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						55	191					0	0	0.014410	0	0
LIMK1	3984	broad.mit.edu	37	7	73526306	73526306	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:73526306C>T	uc003uaa.1	+	12	1553	c.1388C>T	c.(1387-1389)TCC>TTC	p.S463F	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.S429F	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	463	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				GACCTCAACTCCCACAACTGC	0.652													5	52					0	0	0.001984	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	73944175	73944176	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:73944175_73944176CC>TT	uc003uaq.2	+	9	1595_1596	c.1202_1203CC>TT	c.(1201-1203)CCC>CTT	p.P401L	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.P433L|GTF2IRD1_uc003uap.2_Missense_Mutation_p.P401L|GTF2IRD1_uc003uar.1_Missense_Mutation_p.P401L	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	401	GTF2I-like 2.					nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						TTCAAGCGCCCCTGCACTTATG	0.55													5	42					0	0	0.004672	0	0
GTF2I	2969	broad.mit.edu	37	7	74159269	74159269	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:74159269C>T	uc003uau.2	+	21	2293	c.1923C>T	c.(1921-1923)TTC>TTT	p.F641F	GTF2I_uc003uav.2_Silent_p.F620F|GTF2I_uc003uaw.2_Silent_p.F621F|GTF2I_uc003uay.2_Silent_p.F619F|GTF2I_uc003uax.2_Silent_p.F600F	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	641	GTF2I-like 4.				negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						AAATCAAGTTCGTTGTTAAAA	0.413													5	71					0	0	0.000602	0	0
HIP1	3092	broad.mit.edu	37	7	75192332	75192332	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:75192332G>A	uc003uds.1	-	11	968	c.927C>T	c.(925-927)AGC>AGT	p.S309S	HIP1_uc011kfz.1_Silent_p.S186S	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	309					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						CCACCACAGGGCTGATATGTT	0.592			T	PDGFRB	CMML								4	45					0	0	0.000602	0	0
CCL26	10344	broad.mit.edu	37	7	75399065	75399065	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:75399065C>T	uc003udt.1	-	4	339	c.231G>A	c.(229-231)AGG>AGA	p.R77R		NM_006072	NP_006063	Q9Y258	CCL26_HUMAN	chemokine (C-C motif) ligand 26 precursor	77					cell-cell signaling|chemotaxis|immune response|inflammatory response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|signal transduction	extracellular space	chemokine activity				0						CCCATTTTTTCCTTGGATGGG	0.438													5	37					0	0	0.001168	0	0
MDH2	4191	broad.mit.edu	37	7	75686735	75686735	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:75686735C>T	uc003ueo.2	+	3	329	c.243C>T	c.(241-243)CTC>CTT	p.L81L	MDH2_uc003uep.2_5'UTR|MDH2_uc011kgh.1_Silent_p.L81L	NM_005918	NP_005909	P40926	MDHM_HUMAN	mitochondrial malate dehydrogenase precursor	81					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					NADH(DB00157)	TAGGCTACCTCGGACCTGAAC	0.512													11	33					0	0	0.010729	0	0
PION	54103	broad.mit.edu	37	7	77006657	77006657	+	Silent	SNP	G	A	A	rs138204887	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:77006657G>A	uc003ugf.2	-	9	706	c.627C>T	c.(625-627)TTC>TTT	p.F209F	PION_uc003ugg.1_5'UTR	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	209					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						GAGCCCAAACGAAATCCTCAG	0.303													25	128					0	0	0.006320	0	0
HGF	3082	broad.mit.edu	37	7	81339534	81339534	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:81339534C>T	uc003uhl.2	-	13	1635	c.1470G>A	c.(1468-1470)ACG>ACA	p.T490T	HGF_uc003uhm.2_Silent_p.T485T	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	490					epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						GCAATTGTTTCGTTTTGGCAC	0.328													13	34					0	0	0.001855	0	0
CACNA2D1	781	broad.mit.edu	37	7	81600002	81600002	+	Silent	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:81600002A>C	uc003uhr.1	-	27	2449	c.2193T>G	c.(2191-2193)GTT>GTG	p.V731V	CACNA2D1_uc011kgy.1_Missense_Mutation_p.F7C	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	743	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTTTGGGATAAACTCTGGTAA	0.363													11	110					0	0	0.013537	0	0
CACNA2D1	781	broad.mit.edu	37	7	81765956	81765956	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:81765956G>A	uc003uhr.1	-	5	647	c.391C>T	c.(391-393)CTC>TTC	p.L131F		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	131	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTCACATCGAGATCATCCTTT	0.259													4	17					0	0	0.001168	0	0
PCLO	27445	broad.mit.edu	37	7	82388013	82388013	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:82388013C>A	uc003uhx.2	-	25	15596	c.15307G>T	c.(15307-15309)GGA>TGA	p.G5103*		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	5026	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AACTTCCCTCCATTGGAGAAA	0.313													21	42					7.41877e-09	8.04081e-09	0.012319	1	0
PCLO	27445	broad.mit.edu	37	7	82585486	82585486	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:82585486C>T	uc003uhx.2	-	5	5072	c.4783G>A	c.(4783-4785)GAA>AAA	p.E1595K	PCLO_uc003uhv.2_Missense_Mutation_p.E1595K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1526					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTGTTTCTTCCTTCTTCTGG	0.428													15	180					0	0	0.004990	0	0
PCLO	27445	broad.mit.edu	37	7	82595698	82595698	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:82595698G>A	uc003uhx.2	-	4	3695	c.3406C>T	c.(3406-3408)CCT>TCT	p.P1136S	PCLO_uc003uhv.2_Missense_Mutation_p.P1136S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1075					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACAGGCATAGGAGATGCTTTG	0.433													10	83					0	0	0.008291	0	0
SEMA3E	9723	broad.mit.edu	37	7	82997097	82997097	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:82997097C>T	uc003uhy.1	-	17	2599	c.2133G>A	c.(2131-2133)AAG>AAA	p.K711K		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	711					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				GCAAGAATTCCTTGTACCATG	0.453													4	76					0	0	0.009096	0	0
SEMA3D	223117	broad.mit.edu	37	7	84642104	84642104	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:84642104C>T	uc003uic.2	-	15	1802	c.1762G>A	c.(1762-1764)GAA>AAA	p.E588K	SEMA3D_uc010led.2_Missense_Mutation_p.E588K|SEMA3D_uc003uib.2_Missense_Mutation_p.E227K	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	588					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TTACTGTCTTCGATGTCCCAG	0.383													6	52					0	0	0.001984	0	0
ABCB4	5244	broad.mit.edu	37	7	87101970	87101970	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:87101970C>T	uc003uiv.1	-	3	178	c.102G>A	c.(100-102)ACG>ACA	p.T34T	ABCB4_uc003uiw.1_Silent_p.T34T|ABCB4_uc003uix.1_Silent_p.T34T|ABCB4_uc003uiy.2_Silent_p.T34T	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	34	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TCACTGTCTTCGTTTTTTTCC	0.249													8	50					0	0	0.003080	0	0
ABCB1	5243	broad.mit.edu	37	7	87179525	87179525	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:87179525G>A	uc003uiz.1	-	13	1730	c.1312C>T	c.(1312-1314)CAG>TAG	p.Q438*	ABCB1_uc011khc.1_Nonsense_Mutation_p.Q374*	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	438	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TGCATCAGCTGGACTGTTGTG	0.562													8	53					0	0	0.003080	0	0
AKAP9	10142	broad.mit.edu	37	7	91632338	91632338	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:91632338C>T	uc003ulg.2	+	8	3332	c.3107C>T	c.(3106-3108)TCT>TTT	p.S1036F	AKAP9_uc003ule.2_Missense_Mutation_p.S1048F|AKAP9_uc003ulf.2_Missense_Mutation_p.S1036F|AKAP9_uc003uli.2_Missense_Mutation_p.S661F	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1048					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GGATCAGTTTCTAAAGTAAAT	0.358			T	BRAF	papillary thyroid								8	36					0	0	0.004482	0	0
KRIT1	889	broad.mit.edu	37	7	91864731	91864731	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:91864731G>A	uc003ulq.1	-	6	886	c.715C>T	c.(715-717)CAG>TAG	p.Q239*	KRIT1_uc010lev.1_Nonsense_Mutation_p.Q32*|KRIT1_uc003ulr.1_Nonsense_Mutation_p.Q239*|KRIT1_uc003uls.1_Nonsense_Mutation_p.Q239*|KRIT1_uc003ult.1_Nonsense_Mutation_p.Q239*|KRIT1_uc003ulu.1_Nonsense_Mutation_p.Q239*|KRIT1_uc003ulv.1_Nonsense_Mutation_p.Q239*	NM_194456	NP_919438	O00522	KRIT1_HUMAN	krev interaction trapped 1 isoform 1	239					angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTTGTATACTGAAGATCTGAT	0.318									Familial_Cerebral_Cavernous_Angioma				12	56					0	0	0.010729	0	0
PEX1	5189	broad.mit.edu	37	7	92147277	92147277	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:92147277G>A	uc003uly.2	-	5	648	c.552C>T	c.(550-552)GCC>GCT	p.A184A	PEX1_uc011khr.1_5'UTR|PEX1_uc010ley.2_Silent_p.A184A|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	184					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TATTCTCTTTGGCTCGGCGTG	0.393													10	52					0	0	0.006214	0	0
SAMD9	54809	broad.mit.edu	37	7	92730707	92730707	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:92730707C>T	uc003umf.2	-	3	4960	c.4704G>A	c.(4702-4704)GAG>GAA	p.E1568E	SAMD9_uc003umg.2_Silent_p.E1568E	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1568						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			AAGACACCTTCTCTATGCTTC	0.358													8	108					0	0	0.003080	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764617	92764617	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:92764617C>T	uc003umh.1	-	5	1884	c.668G>A	c.(667-669)CGA>CAA	p.R223Q	SAMD9L_uc003umj.1_Missense_Mutation_p.R223Q|SAMD9L_uc003umi.1_Missense_Mutation_p.R223Q|SAMD9L_uc010lfb.1_Missense_Mutation_p.R223Q|SAMD9L_uc003umk.1_Missense_Mutation_p.R223Q|SAMD9L_uc010lfc.1_Missense_Mutation_p.R223Q|SAMD9L_uc010lfd.1_Missense_Mutation_p.R223Q|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	223										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGATGCAAATCGGAAGACTTC	0.418													22	69					0	0	0.014323	0	0
TRRAP	8295	broad.mit.edu	37	7	98507905	98507905	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:98507905C>T	uc003upp.2	+	15	1786	c.1577C>T	c.(1576-1578)CCC>CTC	p.P526L	TRRAP_uc011kis.1_Missense_Mutation_p.P526L|TRRAP_uc003upr.2_Missense_Mutation_p.P218L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	526	Pro-rich.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCCGTGCCTCCCTTCGAGAAG	0.463													6	28					0	0	0.001168	0	0
ZNF394	84124	broad.mit.edu	37	7	99097667	99097667	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:99097667C>T	uc003uqs.2	-	1	211	c.50G>A	c.(49-51)GGA>GAA	p.G17E	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Missense_Mutation_p.G17E	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	17					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CACCCAGGGTCCCAACTCGGC	0.607													13	57					0	0	0.004007	0	0
ZNF498	221785	broad.mit.edu	37	7	99217342	99217342	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:99217342C>T	uc003url.1	+	4	440	c.113C>T	c.(112-114)CCA>CTA	p.P38L	ZNF498_uc003urm.1_5'UTR|ZNF498_uc010lge.1_5'UTR|ZNF498_uc003urn.2_RNA|ZNF498_uc010lgf.1_Missense_Mutation_p.P38L|ZNF498_uc003uro.1_5'Flank	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	38					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GACCCTAGTCCAGAGACTTTT	0.587													11	173					0	0	0.001855	0	0
CYP3A7	1551	broad.mit.edu	37	7	99332688	99332688	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:99332688T>C	uc003uru.2	-	1	134	c.29A>G	c.(28-30)GAA>GGA	p.E10G	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_5'UTR|CYP3A5_uc010lgg.2_Missense_Mutation_p.E10G	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	10					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					AAGCCAGGTTTCCACGGCCAA	0.502													9	45					0	0	0.006214	0	0
CYP3A4	1576	broad.mit.edu	37	7	99361630	99361630	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:99361630C>T	uc003urv.1	-	10	978	c.874G>A	c.(874-876)GAT>AAT	p.D292N	CYP3A4_uc003urw.1_Missense_Mutation_p.D291N|CYP3A4_uc011kiz.1_Missense_Mutation_p.D251N|CYP3A4_uc011kja.1_Missense_Mutation_p.D243N|CYP3A4_uc011kjb.1_Missense_Mutation_p.D142N	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	292					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	AGCTCCAGATCGGACAGAGCT	0.428													5	30					0	0	0.001168	0	0
GPC2	221914	broad.mit.edu	37	7	99771474	99771474	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:99771474G>A	uc003utv.2	-	5	1044	c.876C>T	c.(874-876)GAC>GAT	p.D292D	GPC2_uc010lgr.2_Intron|GPC2_uc003utw.1_3'UTR	NM_152742	NP_689955	Q8N158	GPC2_HUMAN	glypican 2 precursor	292						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|pancreas(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGTTGCCCCAGTCAGGCTCCA	0.443													49	184					0	0	0.014410	0	0
PILRA	29992	broad.mit.edu	37	7	99972025	99972025	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:99972025C>T	uc003uuo.1	+	2	635	c.423C>T	c.(421-423)TCC>TCT	p.S141S	PILRA_uc011kjn.1_Silent_p.S141S|PILRA_uc011kjo.1_Silent_p.S141S|PILRA_uc003uup.1_Silent_p.S141S|PILRA_uc003uuq.1_Silent_p.S141S	NM_013439	NP_038467	Q9UKJ1	PILRA_HUMAN	paired immunoglobulin-like type 2 receptor alpha	141	Extracellular (Potential).|Ig-like V-type.				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity			skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGTGGCAGTCCATCGAGGGGA	0.587													18	78					0	0	0.008871	0	0
C7orf51	222950	broad.mit.edu	37	7	100086302	100086302	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:100086302C>T	uc003uvd.1	+	4	1117	c.958C>T	c.(958-960)CCT>TCT	p.P320S	C7orf51_uc003uve.1_Missense_Mutation_p.P102S	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	320	Pro-rich.									skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAAGACCACTCCTTGTGAAAT	0.687													6	60					0	0	0.003080	0	0
EPO	2056	broad.mit.edu	37	7	100320646	100320646	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:100320646C>T	uc003uwi.2	+	5	653	c.472C>T	c.(472-474)CGA>TGA	p.R158*	EPO_uc011kkc.1_Nonsense_Mutation_p.R157*	NM_000799	NP_000790	P01588	EPO_HUMAN	erythropoietin precursor	158					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	TGCTCCACTCCGAACAATCAC	0.562													11	119					0	0	0.008291	0	0
ZAN	7455	broad.mit.edu	37	7	100350649	100350649	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:100350649A>G	uc003uwj.2	+	14	3086	c.2921A>G	c.(2920-2922)GAA>GGA	p.E974G	ZAN_uc003uwk.2_Missense_Mutation_p.E974G|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	974	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ATCCCCACGGAAAAACTTACC	0.552													9	46					0	0	0.006214	0	0
ZAN	7455	broad.mit.edu	37	7	100361455	100361455	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:100361455C>T	uc003uwj.2	+	21	4178	c.4013C>T	c.(4012-4014)TCC>TTC	p.S1338F	ZAN_uc003uwk.2_Missense_Mutation_p.S1338F|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Intron	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1338	VWFD 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GTGGTGAATTCCCCGTCTTGT	0.557													16	109					0	0	0.006122	0	0
ZAN	7455	broad.mit.edu	37	7	100373332	100373332	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:100373332C>T	uc003uwj.2	+	34	6234	c.6069C>T	c.(6067-6069)ATC>ATT	p.I2023I	ZAN_uc003uwk.2_Silent_p.I2023I|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.I110I	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2023	Extracellular (Potential).|VWFD 3.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TCTCCCAGATCCCTGGGGTCA	0.522													7	42					0	0	0.008291	0	0
ZAN	7455	broad.mit.edu	37	7	100386863	100386863	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:100386863C>T	uc003uwj.2	+	40	7416	c.7251C>T	c.(7249-7251)GTC>GTT	p.V2417V	ZAN_uc003uwk.2_Silent_p.V2417V|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.V467V	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2417	VWFD 4.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGATGGCCGTCCCCTACAGGC	0.567													5	25					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	7	100607867	100607867	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:100607867G>A	uc003uxk.1	+	4		c.2398G>A			uc003uxl.1_Missense_Mutation_p.D572N|uc003uxm.1_RNA|uc003uxn.1_RNA|uc010lhn.1_5'Flank					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		CGCCAGCCAGGATGCGAACAG	0.672													4	20					0	0	0.000602	0	0
MUC17	140453	broad.mit.edu	37	7	100676513	100676513	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:100676513G>A	uc003uxp.1	+	3	1869	c.1816G>A	c.(1816-1818)GAA>AAA	p.E606K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	606	Extracellular (Potential).|8.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACTTCTAGTGAAGCTAGTTC	0.473													25	203					0	0	0.004656	0	0
MUC17	140453	broad.mit.edu	37	7	100686813	100686813	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:100686813C>T	uc003uxp.1	+	3	12169	c.12116C>T	c.(12115-12117)TCT>TTT	p.S4039F	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4039	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACCTCTACTTCTGTCACCACC	0.532													8	126					0	0	0.004482	0	0
LRRC17	10234	broad.mit.edu	37	7	102574798	102574798	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:102574798G>A	uc003vau.2	+	2	827	c.438G>A	c.(436-438)GAG>GAA	p.E146E	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_Silent_p.E146E	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	146	LRR 3.				bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						TCTTGACGGAGGAAGTGTTCA	0.433													10	82					0	0	0.010729	0	0
RELN	5649	broad.mit.edu	37	7	103270438	103270438	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:103270438C>T	uc003vca.2	-	20	2811	c.2651G>A	c.(2650-2652)GGA>GAA	p.G884E	RELN_uc010liz.2_Missense_Mutation_p.G884E	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	884					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AAGGTAGAATCCCAGAGACTG	0.403													5	69					0	0	0.001168	0	0
PUS7	54517	broad.mit.edu	37	7	105142951	105142951	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:105142951G>A	uc003vcx.2	-	5	865	c.646C>T	c.(646-648)CCA>TCA	p.P216S	PUS7_uc010lji.2_Missense_Mutation_p.P216S|PUS7_uc003vcy.2_Missense_Mutation_p.P216S|PUS7_uc003vcz.1_Missense_Mutation_p.P216S	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	216					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						TCTAATCCTGGAAACAGAGAT	0.418													9	75					0	0	0.004482	0	0
PIK3CG	5294	broad.mit.edu	37	7	106509130	106509130	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:106509130G>A	uc003vdv.3	+	2	1209	c.1124G>A	c.(1123-1125)CGG>CAG	p.R375Q	PIK3CG_uc003vdu.2_Missense_Mutation_p.R375Q|PIK3CG_uc003vdw.2_Missense_Mutation_p.R375Q	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	375					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GTCCTGCCTCGGAACACCGAC	0.557													11	46					0	0	0.013537	0	0
PRKAR2B	5577	broad.mit.edu	37	7	106797680	106797680	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:106797680C>T	uc003vdx.2	+	10	1209	c.1034C>T	c.(1033-1035)TCG>TTG	p.S345L		NM_002736	NP_002727	P31323	KAP3_HUMAN	cAMP-dependent protein kinase, regulatory	345	cAMP 2.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1						GCTCGATGCTCGCGGGGACAG	0.458													6	35					0	0	0.001168	0	0
SLC26A3	1811	broad.mit.edu	37	7	107431658	107431658	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:107431658C>T	uc003ver.2	-	5	616	c.405G>A	c.(403-405)ATG>ATA	p.M135I	SLC26A3_uc003ves.2_Missense_Mutation_p.M100I	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	135	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						GTCCCACCATCATACTCAGAA	0.428													18	75					0	0	0.010504	0	0
LAMB4	22798	broad.mit.edu	37	7	107746957	107746957	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:107746957G>A	uc010ljo.1	-	7	736	c.652C>T	c.(652-654)CAA>TAA	p.Q218*	LAMB4_uc003vey.2_Nonsense_Mutation_p.Q218*	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	218	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TTCATACCTTGGATGTAGGGG	0.249													8	17					0	0	0.008291	0	0
ZNF277	11179	broad.mit.edu	37	7	111981074	111981074	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:111981074C>T	uc003vge.2	+	11	1286	c.1157C>T	c.(1156-1158)CCC>CTC	p.P386L	ZNF277_uc003vgf.2_Missense_Mutation_p.P308L|ZNF277_uc003vgg.2_Missense_Mutation_p.P211L	NM_021994	NP_068834	Q9NRM2	ZN277_HUMAN	zinc finger protein (C2H2 type) 277	386						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(2)	4						TCGCTGCTCCCCGATAGAAAG	0.403													3	40					0	0	0.004672	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519087	113519087	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:113519087C>T	uc010ljy.1	-	4	2091	c.2060G>A	c.(2059-2061)GGA>GAA	p.G687E		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	687					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ATCTCTTTTTCCCCACACGTC	0.398													20	240					0	0	0.012319	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519756	113519756	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:113519756C>T	uc010ljy.1	-	4	1422	c.1391G>A	c.(1390-1392)GGA>GAA	p.G464E		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	464					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ATTAAGGTTTCCTGCCATTAG	0.413													19	67					0	0	0.014323	0	0
CAV1	857	broad.mit.edu	37	7	116199076	116199076	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:116199076C>T	uc003vif.1	+	3	550	c.272C>T	c.(271-273)ACC>ATC	p.T91I	CAV1_uc010lkd.1_Missense_Mutation_p.T60I|CAV1_uc010lke.1_Missense_Mutation_p.T60I|CAV1_uc003vig.1_RNA|CAV1_uc003vih.2_Missense_Mutation_p.T60I|CAV1_uc010lkf.1_Missense_Mutation_p.T60I	NM_001753	NP_001744	Q03135	CAV1_HUMAN	caveolin 1	91	Cytoplasmic (Potential).				blood coagulation|calcium ion transport|caveola assembly|cellular response to starvation|cholesterol homeostasis|cytosolic calcium ion homeostasis|inactivation of MAPK activity|interspecies interaction between organisms|leukocyte migration|lipid storage|maintenance of protein location in cell|mammary gland involution|membrane depolarization|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of endothelial cell proliferation|negative regulation of epithelial cell differentiation|negative regulation of nitric oxide biosynthetic process|negative regulation of peptidyl-serine phosphorylation|negative regulation of protein binding|negative regulation of transcription from RNA polymerase II promoter|nitric oxide homeostasis|nitric oxide metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of metalloenzyme activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of vasoconstriction|protein homooligomerization|receptor internalization|regulation of blood coagulation|regulation of fatty acid metabolic process|regulation of nitric-oxide synthase activity|regulation of smooth muscle contraction|response to calcium ion|response to estrogen stimulus|response to hypoxia|response to progesterone stimulus|skeletal muscle tissue development|T cell costimulation|triglyceride metabolic process|vasculogenesis|vesicle organization	apical plasma membrane|basolateral plasma membrane|caveola|caveola|cytosol|endoplasmic reticulum|endosome|Golgi membrane|lipid particle|perinuclear region of cytoplasm	cholesterol binding|nitric-oxide synthase binding|peptidase activator activity|protein binding|protein complex scaffold|receptor binding				0	all_epithelial(6;1.42e-06)|Lung NSC(10;0.0056)|all_lung(10;0.00609)		STAD - Stomach adenocarcinoma(10;0.00878)			AGCTTCACCACCTTCACTGTG	0.473													8	19					0	0	0.004482	0	0
CFTR	1080	broad.mit.edu	37	7	117175412	117175412	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:117175412G>A	uc003vjd.2	+	6	822	c.690G>A	c.(688-690)CTG>CTA	p.L230L	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	230	Helical; Name=4; (Potential).|ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TTGGTTTCCTGATAGTCCTTG	0.448									Cystic_Fibrosis				25	66					0	0	0.003330	0	0
CFTR	1080	broad.mit.edu	37	7	117175424	117175424	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:117175424C>T	uc003vjd.2	+	6	834	c.702C>T	c.(700-702)GCC>GCT	p.A234A	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	234	Helical; Name=4; (Potential).|ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TAGTCCTTGCCCTTTTTCAGG	0.443									Cystic_Fibrosis				6	74					0	0	0.001984	0	0
CFTR	1080	broad.mit.edu	37	7	117199612	117199612	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:117199612G>A	uc003vjd.2	+	11	1619	c.1487G>A	c.(1486-1488)TGG>TAG	p.W496*	CFTR_uc011knq.1_5'UTR|CFTR_uc003vje.1_RNA	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	496	Cytoplasmic (Potential).|ABC transporter 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CAGTTTTCCTGGATTATGCCT	0.388									Cystic_Fibrosis				7	76					0	0	0.003080	0	0
WNT16	51384	broad.mit.edu	37	7	120965496	120965496	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:120965496G>A	uc003vjv.2	+	1	76	c.27G>A	c.(25-27)GAG>GAA	p.E9E		NM_016087	NP_057171	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family,	Error:Variant_position_missing_in_Q9UBV4_after_alignment					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			lung(2)|ovary(2)|large_intestine(1)	5	all_neural(327;0.117)					GCCTCAGGGAGACCCTCTTCA	0.393													17	74					0	0	0.008871	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121650433	121650433	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:121650433C>T	uc003vjy.2	+	12	1728	c.1333C>T	c.(1333-1335)CCT>TCT	p.P445S	PTPRZ1_uc003vjz.2_Missense_Mutation_p.P445S|PTPRZ1_uc011knt.1_5'UTR	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	445	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TATTGTGAATCCTGGTAGAGA	0.388													22	71					0	0	0.014323	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121650827	121650827	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:121650827G>A	uc003vjy.2	+	12	2122	c.1727G>A	c.(1726-1728)AGT>AAT	p.S576N	PTPRZ1_uc003vjz.2_Missense_Mutation_p.S576N|PTPRZ1_uc011knt.1_Missense_Mutation_p.S26N	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	576	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TTATTGACCAGTTTCAAGCTT	0.403													6	43					0	0	0.001168	0	0
IQUB	154865	broad.mit.edu	37	7	123097516	123097516	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:123097516G>A	uc003vkn.2	-	12	2689	c.2112C>T	c.(2110-2112)TCC>TCT	p.S704S	IQUB_uc011kny.1_Silent_p.S37S|IQUB_uc003vko.2_Silent_p.S704S|IQUB_uc010lkt.2_RNA	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	704										ovary(3)|large_intestine(1)	4						ACCACTCCAGGGATTTATTCC	0.453													10	105					0	0	0.008291	0	0
LMOD2	442721	broad.mit.edu	37	7	123302705	123302705	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:123302705G>A	uc003vky.2	+	2	1222	c.1065G>A	c.(1063-1065)CAG>CAA	p.Q355Q		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	355						cytoskeleton	actin binding|tropomyosin binding				0						TGGATAAACAGAGGCAAAAAC	0.473													9	84					0	0	0.008291	0	0
Unknown	0	broad.mit.edu	37	7	124116883	124116883	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:124116883C>T	uc011kod.1	+	1	459	c.459C>T	c.(457-459)TTC>TTT	p.F153F		NM_001085395	NP_001078864			RecName: Full=Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 2;          Short=CTD phosphatase SSU72-like protein 2;          EC=3.1.3.16;																		TGGGAGCTTTCCTCATCTGTG	0.517													6	32					0	0	0.001984	0	0
GRM8	2918	broad.mit.edu	37	7	126882983	126882983	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:126882983G>A	uc003vlr.2	-	1	587	c.276C>T	c.(274-276)CTC>CTT	p.L92L	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.L92L|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	92	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TGTTGGAAAGGAGATCAGGGT	0.502										HNSCC(24;0.065)			5	24					0	0	0.001168	0	0
RBM28	55131	broad.mit.edu	37	7	127953234	127953234	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:127953234G>A	uc003vmp.2	-	18	2254	c.2139C>T	c.(2137-2139)TCC>TCT	p.S713S	RBM28_uc003vmo.2_Silent_p.S255S|RBM28_uc011koj.1_Silent_p.S572S	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	713					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						TCACCTGCTCGGACGATAATT	0.473													19	73					0	0	0.008871	0	0
FLNC	2318	broad.mit.edu	37	7	128484142	128484142	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:128484142C>T	uc003vnz.3	+	20	3223	c.3014C>T	c.(3013-3015)TCG>TTG	p.S1005L	FLNC_uc003voa.3_Missense_Mutation_p.S1005L	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1005	Filamin 8.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CGGATGACTTCGCCCTCTCGC	0.662													4	37					0	0	0.000602	0	0
FAM40B	57464	broad.mit.edu	37	7	129079867	129079867	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:129079867C>T	uc011koy.1	+	2	174	c.134C>T	c.(133-135)TCT>TTT	p.S45F	FAM40B_uc003vow.2_Missense_Mutation_p.S45F	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	45											0						TTACAGGGCTCTGTGGACTGT	0.473													7	69					0	0	0.004482	0	0
TMEM209	84928	broad.mit.edu	37	7	129832510	129832510	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:129832510C>T	uc003vpn.2	-	6	850	c.727G>A	c.(727-729)GAT>AAT	p.D243N	TMEM209_uc010lmc.1_Missense_Mutation_p.D243N	NM_032842	NP_116231	Q96SK2	TM209_HUMAN	transmembrane protein 209	243						integral to membrane				ovary(2)|large_intestine(1)	3	Melanoma(18;0.0435)					AGAAAAGTATCCAAAGTTCGT	0.408													15	30					0	0	0.002450	0	0
MKLN1	4289	broad.mit.edu	37	7	131060248	131060248	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:131060248C>T	uc011kpm.1	+	2	228	c.164C>T	c.(163-165)CCC>CTC	p.P55L	MKLN1_uc011kpl.1_Missense_Mutation_p.P32L|MKLN1_uc010lmh.2_Missense_Mutation_p.P55L|MKLN1_uc003vqs.2_5'UTR	NM_013255	NP_037387	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing	55					signal transduction	cytoplasm	protein binding			breast(1)	1	Melanoma(18;0.162)					AACTATCCTCCCCAGGTAAGA	0.323													10	54					0	0	0.010729	0	0
PLXNA4	91584	broad.mit.edu	37	7	131878938	131878938	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:131878938C>T	uc003vra.3	-	14	2968	c.2739G>A	c.(2737-2739)CAG>CAA	p.Q913Q		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	913	IPT/TIG 1.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CACACACGATCCTGCAGGGAG	0.602													7	74					0	0	0.003080	0	0
PLXNA4	91584	broad.mit.edu	37	7	131982903	131982903	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:131982903C>T	uc003vra.3	-	4	1679	c.1450G>A	c.(1450-1452)GAT>AAT	p.D484N		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	484	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AAGGCCATATCCCGGAGGACT	0.577													14	61					0	0	0.003163	0	0
SLC35B4	84912	broad.mit.edu	37	7	133994124	133994124	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:133994124G>A	uc003vrn.2	-	2	509	c.185C>T	c.(184-186)CCA>CTA	p.P62L	SLC35B4_uc010lmk.2_5'UTR|SLC35B4_uc010lml.1_5'UTR|SLC35B4_uc003vro.3_Missense_Mutation_p.P62L	NM_032826	NP_116215	Q969S0	S35B4_HUMAN	solute carrier family 35, member B4	62	Helical; (Potential).					Golgi membrane|integral to membrane	UDP-N-acetylglucosamine transmembrane transporter activity|UDP-xylose transmembrane transporter activity			skin(1)	1						ATACCTTATTGGGATAGCTGG	0.378													4	7					0	0	0.009096	0	0
AKR1B10	57016	broad.mit.edu	37	7	134222354	134222354	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:134222354C>T	uc003vrr.2	+	7	1002	c.682C>T	c.(682-684)CTG>TTG	p.L228L		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	228					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						AGACCCTTCCCTGCTGGAGGA	0.468													13	82					0	0	0.004007	0	0
BPGM	669	broad.mit.edu	37	7	134346485	134346485	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:134346485C>T	uc003vrv.2	+	3	767	c.226C>T	c.(226-228)CAG>TAG	p.Q76*	BPGM_uc003vrw.2_Nonsense_Mutation_p.Q76*|BPGM_uc003vrx.2_Nonsense_Mutation_p.Q76*	NM_199186	NP_954655	P07738	PMGE_HUMAN	bisphosphoglycerate mutase	76					glycolysis|respiratory gaseous exchange		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						AGAGCTAGGCCAGGAATGGGT	0.493													7	27					0	0	0.003080	0	0
SLC13A4	26266	broad.mit.edu	37	7	135366410	135366410	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:135366410C>T	uc003vta.2	-	16	2471	c.1782G>A	c.(1780-1782)GTG>GTA	p.V594V	SLC13A4_uc003vtb.2_Silent_p.V595V|PL-5283_uc003vsz.3_Intron	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	594	Helical; (Potential).					integral to plasma membrane	sodium:sulfate symporter activity				0						CCATTACTATCACCAGTCCAA	0.542													9	26					0	0	0.004482	0	0
SLC13A4	26266	broad.mit.edu	37	7	135377165	135377165	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:135377165C>T	uc003vta.2	-	11	1815	c.1126G>A	c.(1126-1128)GAA>AAA	p.E376K	SLC13A4_uc003vtb.2_Missense_Mutation_p.E377K|PL-5283_uc003vsz.3_RNA	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	376	Helical; (Potential).					integral to plasma membrane	sodium:sulfate symporter activity				0						GTCACCATTTCTGGGTAGCTA	0.418													13	22					0	0	0.001855	0	0
FAM180A	389558	broad.mit.edu	37	7	135419001	135419002	+	Missense_Mutation	DNP	AG	CA	CA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:135419001_135419002AG>CA	uc003vtd.2	-	3	509_510	c.243_244CT>TG	c.(241-246)GCCTCC>GCTGCC	p.S82A	FAM180A_uc010lmt.2_RNA|FAM180A_uc010lmu.2_Missense_Mutation_p.S82A	NM_205855	NP_995327	Q6UWF9	F180A_HUMAN	hypothetical protein LOC389558 precursor	82						extracellular region				ovary(2)	2						TTCCGCAAGGAGGCCAGCTCCT	0.579													5	110					0	0	0.004672	0	0
CREB3L2	64764	broad.mit.edu	37	7	137567335	137567335	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:137567335G>A	uc003vtw.2	-	11	1705	c.1310C>T	c.(1309-1311)CCC>CTC	p.P437L	CREB3L2_uc003vtv.2_Missense_Mutation_p.P374L	NM_194071	NP_919047	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like	437	Lumenal (Potential).				chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	soft_tissue(158)|upper_aerodigestive_tract(1)|ovary(1)	160						CTCCTCTGGGGGAGAATGTTC	0.582			T	FUS	fibromyxoid sarcoma								6	27					0	0	0.003080	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138447753	138447753	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:138447753C>T	uc003vuf.2	-	5	547	c.309G>A	c.(307-309)CTG>CTA	p.L103L	ATP6V0A4_uc003vug.2_Silent_p.L103L|ATP6V0A4_uc003vuh.2_Silent_p.L103L	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	103	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						ACTCTCCTTCCAGTTTTTCTA	0.418													14	46					0	0	0.001855	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138455977	138455977	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:138455977G>A	uc003vuf.2	-	2	254	c.16C>T	c.(16-18)CGA>TGA	p.R6*	ATP6V0A4_uc003vug.2_Nonsense_Mutation_p.R6*|ATP6V0A4_uc003vuh.2_Nonsense_Mutation_p.R6*	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	6	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						TCCTCGCTTCGAAACACAGAC	0.433													8	119					0	0	0.004482	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603000	138603000	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:138603000C>T	uc011kql.1	-	2	1421	c.1372G>A	c.(1372-1374)GAA>AAA	p.E458K	KIAA1549_uc003vuk.3_Missense_Mutation_p.E408K|KIAA1549_uc011kqj.1_Missense_Mutation_p.E458K	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	458						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						ATGCTGCTTTCTTCCAGCACG	0.507			O	BRAF	pilocytic astrocytoma								4	40					0	0	0.009096	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138764281	138764281	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:138764281G>A	uc003vun.2	-	4	1794	c.1406C>T	c.(1405-1407)TCC>TTC	p.S469F	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Missense_Mutation_p.S469F	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	469					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						GACATCTCGGGAAGCAGGTCC	0.463													11	75					0	0	0.010729	0	0
TTC26	79989	broad.mit.edu	37	7	138872206	138872206	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:138872206C>T	uc003vus.2	+	17	1588	c.1474C>T	c.(1474-1476)CCT>TCT	p.P492S	TTC26_uc011kqn.1_Intron|TTC26_uc011kqo.1_Missense_Mutation_p.P461S|TTC26_uc011kqp.1_Missense_Mutation_p.P387S|TTC26_uc003vut.2_Missense_Mutation_p.P352S|TTC26_uc011kqq.1_Missense_Mutation_p.P361S	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	492	TPR 4.						binding			ovary(1)	1						GAGGCTGGATCCTAACCCTGA	0.443													32	66					0	0	0.012213	0	0
WEE2	494551	broad.mit.edu	37	7	141429368	141429368	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:141429368G>A	uc003vwn.2	+	11	1979	c.1573G>A	c.(1573-1575)GGA>AGA	p.G525R	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	525					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					GTCACCCCAGGGATATACCCA	0.517													6	71					0	0	0.001168	0	0
OR9A4	130075	broad.mit.edu	37	7	141619611	141619611	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:141619611C>T	uc003vwu.1	+	1	936	c.936C>T	c.(934-936)TTC>TTT	p.F312F		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					GTCAACTATTCAGGAATTAGC	0.418													20	52					0	0	0.002780	0	0
TAS2R38	5726	broad.mit.edu	37	7	141673385	141673385	+	Silent	SNP	G	A	A	rs144536521		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:141673385G>A	uc003vwx.1	-	1	189	c.105C>T	c.(103-105)TTC>TTT	p.F35F		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	35	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					CCAAGAAAACGAAGGCATTGG	0.483													10	30					0	0	0.008291	0	0
MGAM	8972	broad.mit.edu	37	7	141762404	141762404	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:141762404C>T	uc003vwy.2	+	35	4213	c.4159C>T	c.(4159-4161)CGT>TGT	p.R1387C		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1387	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AGACTTTTTCCGTAATTCAAC	0.388													5	10					0	0	0.001984	0	0
TRPV5	56302	broad.mit.edu	37	7	142605958	142605958	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:142605958C>T	uc003wby.1	-	15	2176	c.1912G>A	c.(1912-1914)GAT>AAT	p.D638N		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	638	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GGATTCTGATCATTGTGGTTC	0.517													5	38					0	0	0.001168	0	0
C7orf34	135927	broad.mit.edu	37	7	142637500	142637500	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:142637500G>A	uc003wca.2	+	2	311	c.270G>A	c.(268-270)CAG>CAA	p.Q90Q		NM_178829	NP_849151	Q96L11	CG034_HUMAN	hypothetical protein LOC135927	65						extracellular region					0	Melanoma(164;0.059)					AGATGTGGCAGGTGGTGGACA	0.552													8	86					0	0	0.003080	0	0
KEL	3792	broad.mit.edu	37	7	142650939	142650939	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:142650939C>T	uc003wcb.2	-	9	1239	c.1029G>A	c.(1027-1029)TTG>TTA	p.L343L		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	343	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					ACATGTTTTTCAAATATTCCA	0.557													19	193					0	0	0.008871	0	0
KEL	3792	broad.mit.edu	37	7	142651411	142651411	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:142651411C>T	uc003wcb.2	-	8	994	c.784G>A	c.(784-786)GGA>AGA	p.G262R		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	262	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GGGTCTCCTCCCAGCAAGGTT	0.542													9	65					0	0	0.006214	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919715	142919715	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:142919715G>A	uc011ksx.1	+	1	544	c.544G>A	c.(544-546)GAG>AAG	p.E182K		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	182	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					CAACTCCACGGAGAAGAAGTA	0.458													8	118					0	0	0.003080	0	0
CLCN1	1180	broad.mit.edu	37	7	143018564	143018564	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:143018564C>T	uc003wcr.1	+	4	627	c.540C>T	c.(538-540)CAC>CAT	p.H180H	CLCN1_uc011ktc.1_5'UTR|CLCN1_uc003wcs.1_RNA|CLCN1_uc010lox.1_RNA|CLCN1_uc010loy.1_Silent_p.H28H	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	180	Helical; (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					TCTTCTGCCACCTCATCTCTC	0.622													16	67					0	0	0.007413	0	0
TAS2R60	338398	broad.mit.edu	37	7	143140656	143140656	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:143140656C>T	uc011ktg.1	+	1	111	c.111C>T	c.(109-111)TTC>TTT	p.F37F	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	37	Cytoplasmic (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					GCAATGGCTTCATCACTGCTG	0.498													20	102					0	0	0.010504	0	0
TAS2R60	338398	broad.mit.edu	37	7	143140983	143140983	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:143140983C>T	uc011ktg.1	+	1	438	c.438C>T	c.(436-438)TTC>TTT	p.F146F	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	146	Helical; Name=4; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					GGATGCTCTTCAGCTCTGTAG	0.453													10	115					0	0	0.008291	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141184	143141184	+	Missense_Mutation	SNP	G	A	A	rs141559059		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:143141184G>A	uc011ktg.1	+	1	639	c.639G>A	c.(637-639)ATG>ATA	p.M213I	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	213	Cytoplasmic (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity	p.M213I(2)		skin(6)	6	Melanoma(164;0.172)					TCATTTGCATGATTTTGCTCA	0.463													12	100					0	0	0.001855	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175458	143175458	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:143175458T>G	uc003wdc.1	+	1	493	c.493T>G	c.(493-495)TCT>GCT	p.S165A	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	165	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					TAGAAAATTTTCTGGGAACAT	0.393													3	41					0	0	0.009096	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175741	143175741	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:143175741C>T	uc003wdc.1	+	1	776	c.776C>T	c.(775-777)TCC>TTC	p.S259F	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	259	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					AAATTTATCTCCATGCAGAAC	0.478													13	93					0	0	0.003163	0	0
OR2A5	393046	broad.mit.edu	37	7	143747706	143747706	+	Missense_Mutation	SNP	C	T	T	rs149614119	by1000genomes	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:143747706C>T	uc011ktw.1	+	1	212	c.212C>T	c.(211-213)TCG>TTG	p.S71L		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					ATTGATATTTCGTATGCTTCC	0.483													9	50					0	0	0.008291	0	0
OR2A5	393046	broad.mit.edu	37	7	143748174	143748174	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:143748174G>A	uc011ktw.1	+	1	680	c.680G>A	c.(679-681)AGG>AAG	p.R227K		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	227	Cytoplasmic (Potential).			R -> G (in Ref. 3; AAC39630 and 4; AAK95080).	sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					GCCATCTTGAGGATCCAGTCT	0.592													10	94					0	0	0.010729	0	0
OR2A2	442361	broad.mit.edu	37	7	143807483	143807483	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:143807483G>A	uc011ktz.1	+	1	808	c.808G>A	c.(808-810)GAG>AAG	p.E270K		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					AGAGGAGCAGGAGAAAATGCT	0.517													27	135					0	0	0.005443	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144077039	144077039	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:144077039C>T	uc003wel.2	+	15	4802	c.4684C>T	c.(4684-4686)CCT>TCT	p.P1562S	ARHGEF5_uc003wem.2_Missense_Mutation_p.P363S	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1562	SH3.				intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					AGGCTGGTTTCCTGTGCAGCA	0.572													12	116					0	0	0.002450	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146818241	146818241	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:146818241G>A	uc003weu.1	+	6	1441	c.925G>A	c.(925-927)GAC>AAC	p.D309N		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	309	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGACTACCTGGACTTGGACTA	0.433										HNSCC(39;0.1)			7	38					0	0	0.001984	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146825923	146825923	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:146825923A>T	uc003weu.1	+	7	1594	c.1078A>T	c.(1078-1080)AAT>TAT	p.N360Y		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	360	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AGAGCCCTCAAATGTGGTAAG	0.348										HNSCC(39;0.1)			6	104					0	0	0.001168	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146829338	146829338	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:146829338G>A	uc003weu.1	+	8	1601	c.1085G>A	c.(1084-1086)GGA>GAA	p.G362E		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	362	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ATTTTACAGGGAAATTTGAGC	0.433										HNSCC(39;0.1)			8	82					0	0	0.006214	0	0
ZNF425	155054	broad.mit.edu	37	7	148801358	148801358	+	Silent	SNP	G	A	A	rs149172104	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:148801358G>A	uc003wfj.2	-	4	1678	c.1605C>T	c.(1603-1605)TTC>TTT	p.F535F		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	535	C2H2-type 12.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CGCGTCGGCGGAAACTGCGGC	0.617													4	26					0	0	0.009096	0	0
ZNF746	155061	broad.mit.edu	37	7	149174079	149174079	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:149174079G>A	uc003wfw.2	-	6	1043	c.772C>T	c.(772-774)CCC>TCC	p.P258S	ZNF746_uc010lpi.2_Missense_Mutation_p.P258S	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	258					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGATGGTGGGGAGGGAGATCC	0.622													6	57					0	0	0.001168	0	0
SSPO	23145	broad.mit.edu	37	7	149488614	149488614	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:149488614C>T	uc010lpk.2	+	35	5065	c.5065C>T	c.(5065-5067)CCA>TCA	p.P1689S		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1689	LDL-receptor class A 7.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGGCCCCTCCCCAGAAGAGCA	0.721													4	7					0	0	0.001984	0	0
REPIN1	29803	broad.mit.edu	37	7	150069734	150069734	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:150069734C>T	uc010lpq.1	+	4	1893	c.1404C>T	c.(1402-1404)TTC>TTT	p.F468F	REPIN1_uc003whd.2_Silent_p.F457F|REPIN1_uc010lpr.1_Silent_p.F525F|REPIN1_uc003whc.2_Silent_p.F468F|REPIN1_uc003whe.2_Silent_p.F468F	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	468	C2H2-type 12.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			GCAAGGCCTTCCGCCACAAAC	0.701													4	24					0	0	0.000602	0	0
GIMAP6	474344	broad.mit.edu	37	7	150324938	150324938	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:150324938C>T	uc003whn.2	-	3	1172	c.748G>A	c.(748-750)GAA>AAA	p.E250K	GIMAP6_uc003whm.2_Missense_Mutation_p.E170K	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	250							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACTTGCCTTTCCTGTAGTTCT	0.493													14	83					0	0	0.002450	0	0
GIMAP2	26157	broad.mit.edu	37	7	150389491	150389491	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:150389491G>A	uc003who.2	+	3	205	c.117G>A	c.(115-117)GGG>GGA	p.G39G	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	39						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGCTGCAGGGAACAGCATCC	0.512													9	25					0	0	0.004482	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439687	150439687	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:150439687G>A	uc003whr.1	+	3	812	c.460G>A	c.(460-462)GAG>AAG	p.E154K	GIMAP5_uc010lpu.2_Missense_Mutation_p.E12K	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	154	Cytoplasmic (Potential).|GTP (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACCCACAAAGAGGACTTAGG	0.557													15	80					0	0	0.003163	0	0
ABP1	26	broad.mit.edu	37	7	150554840	150554840	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:150554840C>T	uc003why.1	+	3	5500	c.1282C>T	c.(1282-1284)CGG>TGG	p.R428W	ABP1_uc003whz.1_Missense_Mutation_p.R428W|ABP1_uc003wia.1_Missense_Mutation_p.R428W	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	428					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	GGTGCCCCTTCGGCGGCACTT	0.542													5	43					0	0	0.000602	0	0
HTR5A	3361	broad.mit.edu	37	7	154862641	154862641	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:154862641C>T	uc003wlu.1	+	1	96	c.32C>T	c.(31-33)TCC>TTC	p.S11F	uc011kvt.1_Intron|uc003wlt.2_Intron	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	11	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		ACCTCCTTTTCCCTCTCCACC	0.597													14	90					0	0	0.003163	0	0
HTR5A	3361	broad.mit.edu	37	7	154875961	154875961	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr7:154875961G>A	uc003wlu.1	+	2	902	c.838G>A	c.(838-840)GAG>AAG	p.E280K		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	280	Cytoplasmic (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GGAGCAGAAGGAGCAGCGGGC	0.627													14	34					0	0	0.001855	0	0
FBXO25	26260	broad.mit.edu	37	8	401290	401290	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:401290C>T	uc003wox.2	+	7	763	c.497C>T	c.(496-498)CCT>CTT	p.P166L	FBXO25_uc003woy.2_Missense_Mutation_p.P166L|FBXO25_uc003woz.2_Missense_Mutation_p.P99L|FBXO25_uc003wpa.2_5'UTR	NM_183421	NP_904357	Q8TCJ0	FBX25_HUMAN	F-box only protein 25 isoform 1	166						nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			lung(1)	1		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)		CACCACAATCCTCGCTTAATC	0.333													3	41					0	0	0.000602	0	0
MYOM2	9172	broad.mit.edu	37	8	2021482	2021482	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:2021482C>T	uc003wpx.3	+	10	1160	c.1022C>T	c.(1021-1023)TCC>TTC	p.S341F	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	341	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GCCTCCCTGTCCTTCAGCCAC	0.567													7	56					0	0	0.004482	0	0
CSMD1	64478	broad.mit.edu	37	8	2818669	2818669	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:2818669G>A	uc011kwk.1	-	62	10089	c.9699C>T	c.(9697-9699)GGC>GGT	p.G3233G	CSMD1_uc011kwj.1_Silent_p.G2562G|CSMD1_uc010lrg.2_Silent_p.G1124G	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3233	Extracellular (Potential).|Sushi 27.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTACCTCATAGCCTCTGGAGC	0.343													5	18					0	0	0.001168	0	0
CSMD1	64478	broad.mit.edu	37	8	2830730	2830730	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:2830730G>A	uc011kwk.1	-	57	9225	c.8835C>T	c.(8833-8835)TTC>TTT	p.F2945F	CSMD1_uc011kwj.1_Silent_p.F2274F|CSMD1_uc010lrg.2_Silent_p.F955F	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2945	Extracellular (Potential).|Sushi 22.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTTCACAGGAGAAGCGGAGAA	0.542													14	71					0	0	0.002450	0	0
CSMD1	64478	broad.mit.edu	37	8	3326276	3326276	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:3326276C>T	uc011kwk.1	-	12	1912	c.1522G>A	c.(1522-1524)GAT>AAT	p.D508N		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	508	CUB 3.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATGCTATCATCCGACTGCAGA	0.463													3	7					0	0	0.004672	0	0
CSMD1	64478	broad.mit.edu	37	8	3889456	3889456	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:3889456G>A	uc011kwk.1	-	4	971	c.581C>T	c.(580-582)TCG>TTG	p.S194L		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	194	Extracellular (Potential).|Sushi 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GAAGTCCCACGATGCACCATT	0.542													5	18					0	0	0.001168	0	0
SGK223	157285	broad.mit.edu	37	8	8175943	8175943	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:8175943G>A	uc003wsh.3	-	5	3942	c.3942C>T	c.(3940-3942)ATC>ATT	p.I1314I		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	1314	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TGGCCTCGCCGATGCGGATAC	0.716													5	20					0	0	0.000602	0	0
MFHAS1	9258	broad.mit.edu	37	8	8748266	8748267	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:8748266_8748267GG>AA	uc003wsj.1	-	1	2865_2866	c.2302_2303CC>TT	c.(2302-2304)CCG>TTG	p.P768L		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	768											0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		CGCCATGGGCGGGGAGCTTTCC	0.614													4	31					0	0	0.004672	0	0
RP1L1	94137	broad.mit.edu	37	8	10465121	10465121	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:10465121C>T	uc003wtc.2	-	4	6716	c.6487G>A	c.(6487-6489)GGT>AGT	p.G2163S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2163					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GCCTCTATACCTTCTGACTCT	0.602													14	131					0	0	0.001855	0	0
USP17L2	377630	broad.mit.edu	37	8	11994871	11994871	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:11994871G>A	uc003wvc.1	-	1	1399	c.1399C>T	c.(1399-1401)CAT>TAT	p.H467Y	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	467					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						TTCGATTGATGAATCACAAGT	0.478													12	68					0	0	0.010729	0	0
PSD3	23362	broad.mit.edu	37	8	18662374	18662374	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:18662374G>A	uc003wza.2	-	5	1772	c.1669C>T	c.(1669-1671)CAT>TAT	p.H557Y	PSD3_uc003wyy.2_Missense_Mutation_p.H23Y|PSD3_uc003wyz.2_5'UTR	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	557	SEC7.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ATTTCAGAATGAGCTTCTAGC	0.388													14	110					0	0	0.003163	0	0
LPL	4023	broad.mit.edu	37	8	19805839	19805839	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:19805839C>T	uc003wzk.3	+	2	607	c.237C>T	c.(235-237)ATC>ATT	p.I79I		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	79					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	TCATGGTGATCCATGGCTGGA	0.552													14	25					0	0	0.001855	0	0
SLC18A1	6570	broad.mit.edu	37	8	20022595	20022595	+	Silent	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:20022595A>G	uc011kyq.1	-	10	1353	c.882T>C	c.(880-882)TTT>TTC	p.F294F	SLC18A1_uc003wzl.2_Silent_p.F81F|SLC18A1_uc003wzm.2_Silent_p.F294F|SLC18A1_uc011kyr.1_Silent_p.F294F|SLC18A1_uc003wzn.2_Silent_p.F294F|SLC18A1_uc010ltf.2_RNA|SLC18A1_uc003wzo.2_Silent_p.F294F	NM_001135691	NP_001129163	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine),	294	Cytoplasmic (Potential).				neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			ovary(2)	2				Colorectal(74;0.0747)		TGAGAAGCATAAAGAGGGGAG	0.463													9	51					0	0	0.006214	0	0
NPM2	10361	broad.mit.edu	37	8	21891733	21891733	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:21891733C>T	uc003xab.2	+	6	1136	c.478C>T	c.(478-480)CCT>TCT	p.P160S	NPM2_uc003xac.2_Missense_Mutation_p.P160S|NPM2_uc003xad.2_Missense_Mutation_p.P160S|NPM2_uc003xae.2_Missense_Mutation_p.P160S|NPM2_uc003xaf.2_Intron	NM_182795	NP_877724	Q86SE8	NPM2_HUMAN	nucleoplasmin 2	160					chromatin remodeling|embryo development|oocyte differentiation|positive regulation of meiosis|regulation of exit from mitosis|single fertilization	cytoplasmic chromatin|nuclear chromatin	histone binding|nucleic acid binding				0				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		GGAGCAAAGCCCTGTCAAACA	0.368													8	40					0	0	0.003080	0	0
PHYHIP	9796	broad.mit.edu	37	8	22079004	22079004	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:22079004C>T	uc003xbk.3	-	6	1549	c.855G>A	c.(853-855)GAG>GAA	p.E285E	PHYHIP_uc003xbj.3_Silent_p.E285E	NM_001099335	NP_001092805	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	285											0				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		TGTAGATGATCTCCAGGATGA	0.617													7	49					0	0	0.003080	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24250804	24250804	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:24250804G>A	uc003xdz.2	+	3	457	c.237G>A	c.(235-237)CAG>CAA	p.Q79Q	ADAMDEC1_uc010lub.2_5'UTR|ADAMDEC1_uc011lab.1_5'UTR	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	79					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		TTCAATATCAGATGATCTTAA	0.303													9	43					0	0	0.008291	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24253266	24253266	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:24253266G>A	uc003xdz.2	+	5	617	c.397G>A	c.(397-399)GAA>AAA	p.E133K	ADAMDEC1_uc010lub.2_Missense_Mutation_p.E54K|ADAMDEC1_uc011lab.1_Missense_Mutation_p.E54K	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	133					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CATCCTAAATGAAAAGAATTC	0.289													7	26					0	0	0.004482	0	0
EBF2	64641	broad.mit.edu	37	8	25708206	25708206	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:25708206G>A	uc003xes.1	-	15	1617	c.1600C>T	c.(1600-1602)CCT>TCT	p.P534S	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	534	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TTGACAGCAGGAAAAACTGAA	0.507													5	57					0	0	0.000602	0	0
PTK2B	2185	broad.mit.edu	37	8	27288476	27288476	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:27288476C>T	uc003xfn.1	+	13	1561	c.753C>T	c.(751-753)TTC>TTT	p.F251F	PTK2B_uc003xfo.1_Silent_p.F251F|PTK2B_uc003xfp.1_Silent_p.F251F|PTK2B_uc003xfq.1_Silent_p.F251F|PTK2B_uc010luq.1_Silent_p.F22F|PTK2B_uc003xfr.1_5'Flank	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	251	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TGAAGTTCTTCAACACTCTCG	0.577													10	65					0	0	0.006214	0	0
KIF13B	23303	broad.mit.edu	37	8	28967446	28967446	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:28967446G>A	uc003xhh.3	-	33	4131	c.4072C>T	c.(4072-4074)CGT>TGT	p.R1358C	uc003xhi.1_5'Flank	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1358					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		TGGCGCAGACGATCTAAAGTC	0.522													4	11					0	0	0.009096	0	0
DUSP26	78986	broad.mit.edu	37	8	33454892	33454892	+	Silent	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:33454892A>G	uc003xjp.2	-	2	475	c.142T>C	c.(142-144)TTG>CTG	p.L48L	DUSP26_uc003xjq.2_Silent_p.L48L	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	48						Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		AGCCGCTCCAACTCGAAGACA	0.582													5	29					0	0	0.000602	0	0
UNC5D	137970	broad.mit.edu	37	8	35631864	35631864	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:35631864C>T	uc003xjr.1	+	16	2854	c.2526C>T	c.(2524-2526)TTC>TTT	p.F842F	UNC5D_uc003xjs.1_Silent_p.F837F|UNC5D_uc003xju.1_Silent_p.F418F	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	842	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		ACAGCACTTTCCCTGCACAGA	0.468													15	71					0	0	0.004990	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37729768	37729769	+	Missense_Mutation	DNP	CC	TT	TT	rs148745763	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:37729768_37729769CC>TT	uc003xkm.1	-	4	2595_2596	c.2551_2552GG>AA	c.(2551-2553)GGA>AAA	p.G851K	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.G180K|RAB11FIP1_uc003xko.1_Missense_Mutation_p.G180K|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	851					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding	p.G851R(1)		ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			AGGAGGCTCTCCGTCAGACGCG	0.639													5	33					0	0	0.004672	0	0
GOT1L1	137362	broad.mit.edu	37	8	37793365	37793365	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:37793365C>T	uc011lbj.1	-	7	886	c.786G>A	c.(784-786)GTG>GTA	p.V262V		NM_152413	NP_689626	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	262					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			ovary(1)	1	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			CTGCCACCACCACTAGCATCC	0.597													6	52					0	0	0.003080	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38187043	38187044	+	Missense_Mutation	DNP	GG	AT	AT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:38187043_38187044GG>AT	uc003xli.2	-	6	1951_1952	c.1433_1434CC>AT	c.(1432-1434)TCC>TAT	p.S478Y	WHSC1L1_uc011lbm.1_Missense_Mutation_p.S478Y|WHSC1L1_uc010lwe.2_Missense_Mutation_p.S478Y|WHSC1L1_uc003xlj.2_Missense_Mutation_p.S478Y	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	478					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			AAGCTGGTAAGGATTTCCTTGC	0.475			T	NUP98	AML								5	44					0	0	0.004672	0	0
IDO2	169355	broad.mit.edu	37	8	39873104	39873104	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:39873104C>T	uc010lwy.1	+	11	1488	c.1246C>T	c.(1246-1248)CTT>TTT	p.L416F	IDO2_uc003xno.1_RNA|IDO2_uc010lwz.1_Missense_Mutation_p.L157F|IDO2_uc003xnp.1_Missense_Mutation_p.L157F	NM_194294	NP_919270	Q6ZQW0	I23O2_HUMAN	indoleamine-pyrrole 2,3 dioxygenase-like 1	403					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			ovary(2)	2						GGAGTCAATCCTTCACCCACG	0.577													12	56					0	0	0.013537	0	0
ANK1	286	broad.mit.edu	37	8	41545688	41545688	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:41545688C>T	uc003xok.2	-	35	4328	c.4244G>A	c.(4243-4245)GGT>GAT	p.G1415D	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.G731D|ANK1_uc003xoi.2_Missense_Mutation_p.G1415D|ANK1_uc003xoj.2_Missense_Mutation_p.G1415D|ANK1_uc003xol.2_Missense_Mutation_p.G1415D|ANK1_uc003xom.2_Missense_Mutation_p.G1456D	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1415	55 kDa regulatory domain.|Death.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCAGCTGAGACCGAGGTGCTC	0.512													12	111					0	0	0.001855	0	0
ANK1	286	broad.mit.edu	37	8	41563675	41563675	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:41563675C>T	uc003xok.2	-	18	2167	c.2083G>A	c.(2083-2085)GAC>AAC	p.D695N	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.D3N|ANK1_uc003xoi.2_Missense_Mutation_p.D695N|ANK1_uc003xoj.2_Missense_Mutation_p.D695N|ANK1_uc003xol.2_Missense_Mutation_p.D695N|ANK1_uc003xom.2_Missense_Mutation_p.D728N	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	695	ANK 20.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTGGTGGCGTCCACCATGACG	0.542													7	36					0	0	0.004482	0	0
SLC20A2	6575	broad.mit.edu	37	8	42294758	42294758	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:42294758G>A	uc010lxl.2	-	8	1966	c.1272C>T	c.(1270-1272)TCC>TCT	p.S424S	SLC20A2_uc010lxm.2_Silent_p.S424S|SLC20A2_uc003xpe.2_Silent_p.S424S|SLC20A2_uc011lcu.1_Silent_p.S226S	NM_006749	NP_006740	Q08357	S20A2_HUMAN	solute carrier family 20, member 2	424	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			ovary(2)	2	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GCCTCTTCTTGGAGTAGGACA	0.632													8	39					0	0	0.003080	0	0
UBE2V2	7336	broad.mit.edu	37	8	48955640	48955640	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:48955640G>T	uc003xqm.2	+	2	85	c.64G>T	c.(64-66)GGA>TGA	p.G22*		NM_003350	NP_003341	Q15819	UB2V2_HUMAN	ubiquitin-conjugating enzyme E2v2	22					cell proliferation|DNA double-strand break processing|protein polyubiquitination|regulation of DNA repair	cytoplasm|nucleus|UBC13-MMS2 complex	acid-amino acid ligase activity|protein binding				0		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00171)|all_lung(136;0.00196)				ACTTGAAGAAGGACAAAAAGG	0.403								Direct_reversal_of_damage|Rad6_pathway					6	82					5.18039e-06	5.59482e-06	0.003080	1	0
PXDNL	137902	broad.mit.edu	37	8	52366118	52366118	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:52366118G>A	uc003xqu.3	-	10	1311	c.1210C>T	c.(1210-1212)CAC>TAC	p.H404Y		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	404	Ig-like C2-type 2.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ACAGTGCCGTGGCTATTGTTG	0.458													6	49					0	0	0.001168	0	0
ST18	9705	broad.mit.edu	37	8	53071633	53071633	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:53071633C>T	uc003xqz.2	-	10	1787	c.1631G>A	c.(1630-1632)CGA>CAA	p.R544Q	ST18_uc011ldq.1_Missense_Mutation_p.R191Q|ST18_uc011ldr.1_Missense_Mutation_p.R509Q|ST18_uc011lds.1_Missense_Mutation_p.R449Q|ST18_uc003xra.2_Missense_Mutation_p.R544Q|ST18_uc003xrb.2_Missense_Mutation_p.R544Q	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	544						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ACTAGGCAGTCGATTAGGAAA	0.463													10	77					0	0	0.010729	0	0
ST18	9705	broad.mit.edu	37	8	53084431	53084431	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:53084431G>A	uc003xqz.2	-	5	1146	c.990C>T	c.(988-990)TTC>TTT	p.F330F	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Silent_p.F295F|ST18_uc011lds.1_Silent_p.F235F|ST18_uc003xra.2_Silent_p.F330F|ST18_uc003xrb.2_Silent_p.F330F	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	330						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GCTCCAGCAGGAACCTATCCA	0.448													9	78					0	0	0.010729	0	0
OPRK1	4986	broad.mit.edu	37	8	54142068	54142068	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:54142068C>T	uc003xrh.1	-	3	1307	c.932G>A	c.(931-933)AGC>AAC	p.S311N	OPRK1_uc003xri.1_Missense_Mutation_p.S311N|OPRK1_uc010lyc.1_Missense_Mutation_p.S222N	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	311	Extracellular (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	GAAGTAATAGCTGGAGAGAGC	0.527													3	28					0	0	0.004672	0	0
RP1	6101	broad.mit.edu	37	8	55538837	55538837	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:55538837G>A	uc003xsd.1	+	4	2543	c.2395G>A	c.(2395-2397)GAT>AAT	p.D799N	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	799					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CGGTCAAAGAGATAAAGTGTT	0.294													9	45					0	0	0.006214	0	0
RP1	6101	broad.mit.edu	37	8	55539144	55539144	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:55539144C>T	uc003xsd.1	+	4	2850	c.2702C>T	c.(2701-2703)CCT>CTT	p.P901L	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	901					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGAAAAAACCTGATTTTCCT	0.333													10	20					0	0	0.006214	0	0
RP1	6101	broad.mit.edu	37	8	55539308	55539308	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:55539308G>A	uc003xsd.1	+	4	3014	c.2866G>A	c.(2866-2868)GAT>AAT	p.D956N	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	956					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCAGGGAATGATCCCCATAC	0.313													6	42					0	0	0.001168	0	0
PLAG1	5324	broad.mit.edu	37	8	57078987	57078988	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:57078987_57078988GG>AA	uc003xsq.3	-	3	1768_1769	c.1317_1318CC>TT	c.(1315-1320)AGCCTT>AGTTTT	p.L440F	PLAG1_uc003xsr.3_Missense_Mutation_p.L440F|PLAG1_uc010lyi.2_Missense_Mutation_p.L440F|PLAG1_uc010lyj.2_Missense_Mutation_p.L358F	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	440	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Massively activates transcription.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			CTCATTCCAAGGCTCCCCACTG	0.46			T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								7	68					0	0	0.004672	0	0
PENK	5179	broad.mit.edu	37	8	57354009	57354009	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:57354009C>T	uc003xsz.2	-	2	707	c.626G>A	c.(625-627)CGA>CAA	p.R209Q	PENK_uc003xta.3_Missense_Mutation_p.R209Q	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	209					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GCCCCCATATCGCTTCTGCAG	0.522													32	68					0	0	0.013726	0	0
CHD7	55636	broad.mit.edu	37	8	61765994	61765994	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:61765994C>T	uc003xue.2	+	31	7187	c.6710C>T	c.(6709-6711)TCC>TTC	p.S2237F		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2237	Glu-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GAGAAAGGTTCCGAAGAGGAT	0.522													6	35					0	0	0.004482	0	0
LRRC67	286187	broad.mit.edu	37	8	67925324	67925324	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:67925324C>T	uc003xxc.2	-	4	449	c.304G>A	c.(304-306)GGA>AGA	p.G102R		NM_001013626	NP_001013648	Q7Z4L9	LRC67_HUMAN	leucine rich repeat containing 67	102	LRR 4.										0						TAATTGCCTCCCAGATACCTG	0.383													14	35					0	0	0.003163	0	0
CPA6	57094	broad.mit.edu	37	8	68346387	68346387	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:68346387G>A	uc003xxq.3	-	9	1183	c.927C>T	c.(925-927)TTC>TTT	p.F309F	CPA6_uc003xxr.3_Intron	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	309					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			GTTTTCGAAGGAAGTTAGCTA	0.433													15	30					0	0	0.004990	0	0
PREX2	80243	broad.mit.edu	37	8	68950487	68950487	+	Missense_Mutation	SNP	C	T	T	rs138740482		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:68950487C>T	uc003xxv.1	+	7	826	c.799C>T	c.(799-801)CTT>TTT	p.L267F	PREX2_uc003xxu.1_Missense_Mutation_p.L267F|PREX2_uc011lez.1_Missense_Mutation_p.L202F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	267	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.L267F(1)		skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GGTGTTTTTTCTTTTCGATAA	0.408													3	31					0	0	0.009096	0	0
XKR9	389668	broad.mit.edu	37	8	71619234	71619234	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:71619234C>T	uc003xyq.2	+	4	873	c.339C>T	c.(337-339)TTC>TTT	p.F113F	XKR9_uc010lze.2_Silent_p.F113F|XKR9_uc010lzd.2_5'UTR	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	113						integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			CTAGTAACTTCGTGGAAGAAC	0.358													4	34					0	0	0.009096	0	0
KCNB2	9312	broad.mit.edu	37	8	73848257	73848257	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:73848257G>A	uc003xzb.2	+	3	1255	c.667G>A	c.(667-669)GAA>AAA	p.E223K		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	223					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GGAAACGGACGAATTTGGACA	0.478													26	81					0	0	0.003330	0	0
KCNB2	9312	broad.mit.edu	37	8	73848625	73848625	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:73848625G>A	uc003xzb.2	+	3	1623	c.1035G>A	c.(1033-1035)GGG>GGA	p.G345G		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	345	Helical; Name=Segment S5; (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TGGCCATGGGGATAATGATAT	0.473													20	92					0	0	0.014323	0	0
JPH1	56704	broad.mit.edu	37	8	75227223	75227223	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:75227223G>A	uc003yae.2	-	2	1052	c.1012C>T	c.(1012-1014)CGT>TGT	p.R338C	JPH1_uc003yaf.2_Missense_Mutation_p.R338C|JPH1_uc003yag.1_Missense_Mutation_p.R202C	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	338	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CTTATCCCACGGACCAGAATA	0.473													9	91					0	0	0.004482	0	0
HNF4G	3174	broad.mit.edu	37	8	76471254	76471254	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:76471254C>T	uc003yaq.2	+	9	1234	c.964C>T	c.(964-966)CAG>TAG	p.Q322*	HNF4G_uc003yar.2_Nonsense_Mutation_p.Q359*	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	322					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			CAATCTACTTCAGGAAATGCT	0.348													14	54					0	0	0.003163	0	0
HNF4G	3174	broad.mit.edu	37	8	76471257	76471257	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:76471257G>A	uc003yaq.2	+	9	1237	c.967G>A	c.(967-969)GAA>AAA	p.E323K	HNF4G_uc003yar.2_Missense_Mutation_p.E360K	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	323					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TCTACTTCAGGAAATGCTATT	0.338													4	66					0	0	0.009096	0	0
ZFHX4	79776	broad.mit.edu	37	8	77775788	77775788	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:77775788G>A	uc003yav.2	+	11	10090	c.9703G>A	c.(9703-9705)GGA>AGA	p.G3235R		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3231						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A3235G(1)		ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCAGCTCCCTGGAACAGTGCA	0.527										HNSCC(33;0.089)			30	57					0	0	0.010818	0	0
PMP2	5375	broad.mit.edu	37	8	82357172	82357172	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:82357172G>A	uc003ycb.1	-	2	224	c.126C>T	c.(124-126)ATC>ATT	p.I42I	PMP2_uc010lzv.1_Intron	NM_002677	NP_002668	P02689	MYP2_HUMAN	peripheral myelin protein 2	42						cytoplasm	cholesterol binding|fatty acid binding|transporter activity				0			Epithelial(68;0.186)			TCTTGCTGATGATCACAGTGG	0.388													5	40					0	0	0.000602	0	0
CA2	760	broad.mit.edu	37	8	86389390	86389390	+	Silent	SNP	C	T	T	rs151021025	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:86389390C>T	uc003ydk.2	+	6	729	c.549C>T	c.(547-549)CTC>CTT	p.L183L		NM_000067	NP_000058	P00918	CAH2_HUMAN	carbonic anhydrase II	183					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(1)	1					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	CTCGTGGCCTCCTTCCTGAAT	0.507													55	143					0	0	0.014410	0	0
PSKH2	85481	broad.mit.edu	37	8	87076634	87076634	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:87076634C>T	uc011lfy.1	-	2	412	c.412G>A	c.(412-414)GAG>AAG	p.E138K		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	138	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			GTAGCCAGCTCCATTACCATG	0.537													6	47					0	0	0.001168	0	0
WWP1	11059	broad.mit.edu	37	8	87393068	87393069	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:87393068_87393069CC>TT	uc003ydt.2	+	4	464_465	c.184_185CC>TT	c.(184-186)CCA>TTA	p.P62L	WWP1_uc010mai.2_5'UTR	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	62	C2.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						TTCTTCTAATCCAAAATGGGAT	0.322													4	19					0	0	0.004672	0	0
CNGB3	54714	broad.mit.edu	37	8	87641295	87641295	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:87641295C>T	uc003ydx.2	-	12	1378	c.1332G>A	c.(1330-1332)GTG>GTA	p.V444V	CNGB3_uc010maj.2_Silent_p.V306V	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	444	Extracellular (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						CTGCTCCAATCACATCTCTCA	0.418													50	122					0	0	0.014410	0	0
MMP16	4325	broad.mit.edu	37	8	89086955	89086955	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:89086955C>T	uc003yeb.3	-	7	1382	c.1100G>A	c.(1099-1101)CGA>CAA	p.R367Q	MMP16_uc003yec.2_Missense_Mutation_p.R367Q	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	367	Extracellular (Potential).|Hemopexin-like 1.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						GTTTCTCACTCGCCAAAACCA	0.488													7	93					0	0	0.004482	0	0
DECR1	1666	broad.mit.edu	37	8	91031361	91031361	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:91031361C>G	uc003yek.1	+	4	519	c.378C>G	c.(376-378)AAC>AAG	p.N126K	DECR1_uc011lgc.1_Missense_Mutation_p.N117K|DECR1_uc011lgd.1_RNA	NM_001359	NP_001350	Q16698	DECR_HUMAN	2,4-dienoyl CoA reductase 1 precursor	126					fatty acid beta-oxidation|protein homotetramerization	mitochondrial matrix|nucleus|plasma membrane	2,4-dienoyl-CoA reductase (NADPH) activity|NADPH binding|oxidoreductase activity, acting on NADH or NADPH				0			BRCA - Breast invasive adenocarcinoma(11;0.00953)			TGGTTCAAAACACTGTGTCAG	0.393													6	38					0	0	0.001984	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017381	93017381	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:93017381C>T	uc003yfd.2	-	5	787	c.703G>A	c.(703-705)GAT>AAT	p.D235N	RUNX1T1_uc003yfc.1_Missense_Mutation_p.D208N|RUNX1T1_uc003yfe.1_Missense_Mutation_p.D198N|RUNX1T1_uc010mao.2_Missense_Mutation_p.D208N|RUNX1T1_uc011lgi.1_Missense_Mutation_p.D246N|RUNX1T1_uc003yfb.1_Missense_Mutation_p.D198N|RUNX1T1_uc003yff.1_Missense_Mutation_p.D198N	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	235					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCGTTCACATCGAGAAGCAGC	0.552													7	69					0	0	0.001984	0	0
RBM12B	389677	broad.mit.edu	37	8	94748427	94748427	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:94748427A>C	uc003yfz.2	-	3	405	c.212T>G	c.(211-213)CTC>CGC	p.L71R		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	71							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			ACTAAGAAAGAGCTCTACAGA	0.443													10	96					0	0	0.006214	0	0
KIAA1429	25962	broad.mit.edu	37	8	95539313	95539313	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:95539313C>T	uc003ygo.1	-	8	1172	c.1159G>A	c.(1159-1161)GAA>AAA	p.E387K	KIAA1429_uc003ygp.2_Missense_Mutation_p.E387K|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	387					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCTAAGAGTTCTGTTAACTTC	0.338													13	151					0	0	0.013537	0	0
ESRP1	54845	broad.mit.edu	37	8	95674533	95674533	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:95674533G>A	uc003ygq.3	+	5	707	c.524G>A	c.(523-525)CGA>CAA	p.R175Q	ESRP1_uc003ygr.3_Missense_Mutation_p.R175Q|ESRP1_uc003ygs.3_Missense_Mutation_p.R175Q|ESRP1_uc003ygt.3_Missense_Mutation_p.R175Q|ESRP1_uc003ygu.3_Missense_Mutation_p.R175Q|ESRP1_uc003ygv.2_Missense_Mutation_p.R15Q|ESRP1_uc003ygw.2_Missense_Mutation_p.R15Q	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	175					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						TCAGTCTCTCGATATGGAGCC	0.318													41	353					0	0	0.013114	0	0
VPS13B	157680	broad.mit.edu	37	8	100403879	100403879	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:100403879C>T	uc003yiv.2	+	21	3140	c.3029C>T	c.(3028-3030)TCA>TTA	p.S1010L	VPS13B_uc003yiw.2_Missense_Mutation_p.S1010L|VPS13B_uc003yiu.1_Missense_Mutation_p.S1010L|VPS13B_uc003yix.1_Missense_Mutation_p.S480L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1010					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAGCAGCAATCATATCAGGCC	0.373													8	39					0	0	0.003080	0	0
NCALD	83988	broad.mit.edu	37	8	102705104	102705105	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:102705104_102705105GG>AA	uc003yke.2	-	3	767_768	c.398_399CC>TT	c.(397-399)TCC>TTT	p.S133F	NCALD_uc003ykf.2_Missense_Mutation_p.S133F|NCALD_uc003ykg.2_Missense_Mutation_p.S133F|NCALD_uc003ykh.2_Missense_Mutation_p.S133F|NCALD_uc003yki.2_Missense_Mutation_p.S133F|NCALD_uc003ykj.2_Missense_Mutation_p.S133F|NCALD_uc003ykk.2_Missense_Mutation_p.S133F|NCALD_uc003ykl.2_Missense_Mutation_p.S133F	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	133					synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			TCATTACAGAGGAAACCATCTT	0.465													9	42					0	0	0.004672	0	0
FZD6	8323	broad.mit.edu	37	8	104340629	104340629	+	Missense_Mutation	SNP	G	A	A	rs143405641		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:104340629G>A	uc003ylh.2	+	5	1810	c.1526G>A	c.(1525-1527)CGA>CAA	p.R509Q	FZD6_uc003yli.2_Missense_Mutation_p.R509Q|FZD6_uc003ylj.2_Missense_Mutation_p.R509Q|FZD6_uc011lhn.1_Missense_Mutation_p.R475Q|FZD6_uc011lho.1_Missense_Mutation_p.R204Q|FZD6_uc011lhp.1_Missense_Mutation_p.R454Q	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	509	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			TTTTTTAAACGAAATCGCAAG	0.338													6	28					0	0	0.003080	0	0
RIMS2	9699	broad.mit.edu	37	8	104927725	104927725	+	Silent	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:104927725T>G	uc003yls.2	+	5	1390	c.1149T>G	c.(1147-1149)GTT>GTG	p.V383V	RIMS2_uc003ylp.2_Silent_p.V605V|RIMS2_uc003ylw.2_Silent_p.V413V|RIMS2_uc003ylq.2_Silent_p.V413V|RIMS2_uc003ylr.2_Silent_p.V460V|RIMS2_uc003ylt.2_Silent_p.V6V|RIMS2_uc003ylu.1_5'UTR|RIMS2_uc003ylv.1_5'UTR	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	683	PDZ.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TTAAACAGGTTGTAGGAGGAA	0.348										HNSCC(12;0.0054)			3	21					0	0	0.004672	0	0
LRP12	29967	broad.mit.edu	37	8	105509935	105509935	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:105509935C>T	uc003yma.2	-	5	940	c.845G>A	c.(844-846)GGA>GAA	p.G282E	LRP12_uc003ymb.2_Missense_Mutation_p.G263E|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	282	Extracellular (Potential).|CUB 2.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GCAATTGCTTCCAGGAGGATA	0.388													5	28					0	0	0.000602	0	0
EIF3E	3646	broad.mit.edu	37	8	109240513	109240513	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:109240513G>A	uc003ymu.2	-	7	733	c.705C>T	c.(703-705)CTC>CTT	p.L235L	EIF3E_uc003ymt.2_Silent_p.L186L|EIF3E_uc003ymv.2_Silent_p.L142L|EIF3E_uc010mci.1_Silent_p.L235L	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	235					negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			GATAAAGGAAGAGGTCAATAA	0.348													5	68					0	0	0.001168	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110413730	110413730	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:110413730G>A	uc003yne.2	+	14	1390	c.1286G>A	c.(1285-1287)AGG>AAG	p.R429K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	429	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GATTAGGTGAGGATTGCATAT	0.323										HNSCC(38;0.096)			16	17					0	0	0.012319	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110431368	110431368	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:110431368G>A	uc003yne.2	+	22	2507	c.2403G>A	c.(2401-2403)ACG>ACA	p.T801T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	801	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCGTAAGAACGAAATACACTG	0.373										HNSCC(38;0.096)			9	45					0	0	0.010729	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110447558	110447558	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:110447558C>T	uc003yne.2	+	29	3584	c.3480C>T	c.(3478-3480)ATC>ATT	p.I1160I		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1160	Extracellular (Potential).|IPT/TIG 5.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCTCACATATCTGGCCTGATT	0.433										HNSCC(38;0.096)			18	170					0	0	0.002780	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457235	110457235	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:110457235G>A	uc003yne.2	+	38	5241	c.5137G>A	c.(5137-5139)GAA>AAA	p.E1713K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1713	IPT/TIG 9.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CATTGAATGTGAAACATCCCC	0.443										HNSCC(38;0.096)			20	194					0	0	0.003330	0	0
SYBU	55638	broad.mit.edu	37	8	110587270	110587270	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:110587270G>A	uc003ynj.3	-	7	2020	c.1857C>T	c.(1855-1857)GTC>GTT	p.V619V	SYBU_uc003yni.3_Silent_p.V616V|SYBU_uc003ynk.3_Silent_p.V500V|SYBU_uc010mco.2_Silent_p.V618V|SYBU_uc003ynl.3_Silent_p.V618V|SYBU_uc010mcp.2_Silent_p.V619V|SYBU_uc010mcq.2_Silent_p.V619V|SYBU_uc003yno.3_Silent_p.V500V|SYBU_uc010mcr.2_Silent_p.V619V|SYBU_uc003ynm.3_Silent_p.V618V|SYBU_uc003ynn.3_Silent_p.V618V|SYBU_uc010mcs.2_Silent_p.V500V|SYBU_uc010mct.2_Silent_p.V619V|SYBU_uc010mcu.2_Silent_p.V618V|SYBU_uc003ynp.3_Silent_p.V551V|SYBU_uc010mcv.2_Silent_p.V619V|SYBU_uc003ynh.3_Silent_p.V413V|SYBU_uc011lhw.1_Silent_p.V489V	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	619	Helical; (Potential).					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						GAACCGTGGGGACCACGGGGG	0.622													13	57					0	0	0.004007	0	0
CSMD3	114788	broad.mit.edu	37	8	113326250	113326250	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:113326250G>A	uc003ynu.2	-	49	7740	c.7581C>T	c.(7579-7581)TCC>TCT	p.S2527S	CSMD3_uc003yns.2_Silent_p.S1729S|CSMD3_uc003ynt.2_Silent_p.S2487S|CSMD3_uc011lhx.1_Silent_p.S2423S|CSMD3_uc003ynw.1_Silent_p.S238S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2527	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCCCACTGAGGGAAATAAGCA	0.318										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	51					0	0	0.000602	0	0
CSMD3	114788	broad.mit.edu	37	8	113353862	113353862	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:113353862C>T	uc003ynu.2	-	42	6655	c.6496G>A	c.(6496-6498)GAA>AAA	p.E2166K	CSMD3_uc003yns.2_Missense_Mutation_p.E1368K|CSMD3_uc003ynt.2_Missense_Mutation_p.E2126K|CSMD3_uc011lhx.1_Missense_Mutation_p.E2062K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2166	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTCGTACTTCCAAATAATCA	0.383										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	35					0	0	0.001168	0	0
CSMD3	114788	broad.mit.edu	37	8	114031305	114031305	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:114031305G>A	uc003ynu.2	-	6	1180	c.1021C>T	c.(1021-1023)CCC>TCC	p.P341S	CSMD3_uc003ynt.2_Missense_Mutation_p.P301S|CSMD3_uc011lhx.1_Missense_Mutation_p.P341S|CSMD3_uc010mcx.1_Missense_Mutation_p.P341S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	341	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCTTGATAGGGAGCACTAAAT	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	31					0	0	0.003330	0	0
EIF3H	8667	broad.mit.edu	37	8	117768029	117768029	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:117768029G>A	uc003yoa.2	-	1	34	c.8C>T	c.(7-9)TCC>TTC	p.S3F	EIF3H_uc003yob.2_Missense_Mutation_p.S17F|EIF3H_uc011lhz.1_Missense_Mutation_p.S3F	NM_003756	NP_003747	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3,	3					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					TTCCTTGCGGGACGCCATCTT	0.607													6	19					0	0	0.001984	0	0
HAS2	3037	broad.mit.edu	37	8	122626661	122626662	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:122626661_122626662GG>AA	uc003yph.2	-	4	1884_1885	c.1346_1347CC>TT	c.(1345-1347)CCC>CTT	p.P449L		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	449	Helical; Name=5; (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			ACATCTTGGCGGGAAGTAAACT	0.411													45	74					0	0	0.004672	0	0
FER1L6	654463	broad.mit.edu	37	8	124989698	124989698	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:124989698G>A	uc003yqw.2	+	10	1118	c.912G>A	c.(910-912)TGG>TGA	p.W304*		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	304	C2 2.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ATCCTGTGTGGCATGAACAGG	0.507													5	113					0	0	0.001168	0	0
FER1L6	654463	broad.mit.edu	37	8	124992757	124992757	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:124992757G>A	uc003yqw.2	+	11	1322	c.1116G>A	c.(1114-1116)AGG>AGA	p.R372R		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	372	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GCTCGCCCAGGAACCACAGTC	0.463											OREG0018964	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	74					0	0	0.005524	0	0
FER1L6	654463	broad.mit.edu	37	8	125103772	125103772	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:125103772G>A	uc003yqw.2	+	34	4706	c.4500G>A	c.(4498-4500)CAG>CAA	p.Q1500Q	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1500	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GGAAAATACAGATAGGAAACC	0.443													11	43					0	0	0.008291	0	0
ADCY8	114	broad.mit.edu	37	8	131916206	131916206	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:131916206C>T	uc003ytd.3	-	7	1979	c.1723G>A	c.(1723-1725)GAA>AAA	p.E575K	ADCY8_uc010mds.2_Missense_Mutation_p.E575K	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	575	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTCAGGAATTCATTCCTCTCT	0.463										HNSCC(32;0.087)			12	145					0	0	0.001855	0	0
ADCY8	114	broad.mit.edu	37	8	131922025	131922025	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:131922025C>T	uc003ytd.3	-	6	1825	c.1569G>A	c.(1567-1569)AGG>AGA	p.R523R	ADCY8_uc010mds.2_Silent_p.R523R	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	523	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			ACTGCCACTTCCTTAGTCCCA	0.478										HNSCC(32;0.087)			19	136					0	0	0.008871	0	0
ADCY8	114	broad.mit.edu	37	8	131949419	131949419	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:131949419G>A	uc003ytd.3	-	5	1637	c.1381C>T	c.(1381-1383)CTG>TTG	p.L461L	ADCY8_uc010mds.2_Silent_p.L461L	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	461	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CAGTCCCCCAGGATTTTAATA	0.502										HNSCC(32;0.087)			9	26					0	0	0.004482	0	0
TG	7038	broad.mit.edu	37	8	133981775	133981775	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:133981775G>A	uc003ytw.2	+	32	5977	c.5936G>A	c.(5935-5937)AGA>AAA	p.R1979K	TG_uc010mdw.2_Missense_Mutation_p.R738K|TG_uc011ljb.1_Missense_Mutation_p.R348K|TG_uc011ljc.1_Missense_Mutation_p.R133K	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1979	Type IIIA.		R -> W (polymorphism associated with AITD3).		hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ATATCCATTAGAAATAAAGTG	0.348													7	124					0	0	0.001984	0	0
TG	7038	broad.mit.edu	37	8	134145864	134145864	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:134145864C>T	uc003ytw.2	+	47	8189	c.8148C>T	c.(8146-8148)TCC>TCT	p.S2716S	TG_uc010mdw.2_Silent_p.S1475S|TG_uc011ljb.1_Silent_p.S1085S|TG_uc011ljc.1_Silent_p.S849S	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2716					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCGACTGCTCCTTCTGGTCCA	0.562													4	14					0	0	0.000602	0	0
NDRG1	10397	broad.mit.edu	37	8	134276895	134276895	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:134276895C>T	uc003yuh.2	-	4	686	c.100G>A	c.(100-102)GAG>AAG	p.E34K	NDRG1_uc003yug.2_Missense_Mutation_p.E34K|NDRG1_uc010mee.2_Intron|NDRG1_uc010mef.2_5'UTR|NDRG1_uc011ljh.1_5'UTR|NDRG1_uc011lji.1_Intron	NM_001135242	NP_001128714	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	34					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding			ovary(4)	4	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			ATGTCCTGCTCCTGAGGAGAC	0.557													7	38					0	0	0.001984	0	0
GPR20	2843	broad.mit.edu	37	8	142367810	142367810	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:142367810C>T	uc003ywf.2	-	2	303	c.214G>A	c.(214-216)GGG>AGG	p.G72R		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	72	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			AGCGCCAGCCCGTTGAGCACC	0.647													10	24					0	0	0.006214	0	0
BAI1	575	broad.mit.edu	37	8	143569733	143569733	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:143569733A>G	uc003ywm.2	+	13	2500	c.2317A>G	c.(2317-2319)ATC>GTC	p.I773V		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	773	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					AGTTCTCAGCATCCATAAGCT	0.637													26	66					0	0	0.008361	0	0
GML	2765	broad.mit.edu	37	8	143927822	143927822	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:143927822C>T	uc003yxg.2	+	4	283	c.193C>T	c.(193-195)CGT>TGT	p.R65C		NM_002066	NP_002057	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule	65	UPAR/Ly6.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane				central_nervous_system(2)	2	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CATAAATTCTCGTGAACTACT	0.343													4	32					0	0	0.009096	0	0
RHPN1	114822	broad.mit.edu	37	8	144463806	144463806	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:144463806G>A	uc003yyb.2	+	13	1686	c.1553G>A	c.(1552-1554)CGA>CAA	p.R518Q		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	543	PDZ.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CACCTGACCCGAGGAGAGGGC	0.711													5	27					0	0	0.000602	0	0
ZNF623	9831	broad.mit.edu	37	8	144732612	144732612	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:144732612C>G	uc003yzd.2	+	1	659	c.570C>G	c.(568-570)CAC>CAG	p.H190Q	ZNF623_uc011lkp.1_Missense_Mutation_p.H150Q|ZNF623_uc003yzc.2_Missense_Mutation_p.H150Q	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	190	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			ACTTCATTCACTATTCAGGTC	0.473													9	53					0	0	0.004482	0	0
SCRIB	23513	broad.mit.edu	37	8	144894450	144894450	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:144894450C>T	uc003yzp.1	-	9	899	c.892G>A	c.(892-894)GAG>AAG	p.E298K	SCRIB_uc003yzo.1_Missense_Mutation_p.E298K	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	298	LRR 12.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGCAGGTTCTCCGTGAGGATC	0.597													18	55					0	0	0.007413	0	0
PUF60	22827	broad.mit.edu	37	8	144900174	144900174	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:144900174G>A	uc003yzs.2	-	8	739	c.675C>T	c.(673-675)TTC>TTT	p.F225F	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Silent_p.F165F|PUF60_uc003yzt.2_Silent_p.F208F|PUF60_uc003yzq.2_Silent_p.F182F|PUF60_uc003yzu.1_Silent_p.F214F	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	225	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGATGCGGTTGAAGGCCCGTG	0.592													7	20					0	0	0.003080	0	0
EPPK1	83481	broad.mit.edu	37	8	144941146	144941146	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:144941146G>A	uc003zaa.1	-	1	6289	c.6276C>T	c.(6274-6276)TCC>TCT	p.S2092S		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2092						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGATGTGCTCGGAGTCCCGTG	0.597													10	104					0	0	0.008291	0	0
PLEC	5339	broad.mit.edu	37	8	144990957	144990957	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:144990957G>A	uc003zaf.1	-	32	13613	c.13443C>T	c.(13441-13443)ATC>ATT	p.I4481I	PLEC_uc003zab.1_Silent_p.I4344I|PLEC_uc003zac.1_Silent_p.I4348I|PLEC_uc003zad.2_Silent_p.I4344I|PLEC_uc003zae.1_Silent_p.I4312I|PLEC_uc003zag.1_Silent_p.I4322I|PLEC_uc003zah.2_Silent_p.I4330I|PLEC_uc003zaj.2_Silent_p.I4371I	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4481	Globular 2.|Plectin 30.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GGTCCACCATGATCTTGTCCA	0.657													19	53					0	0	0.007413	0	0
SLC39A4	55630	broad.mit.edu	37	8	145640396	145640396	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:145640396G>A	uc003zcq.2	-	4	866	c.766C>T	c.(766-768)CTC>TTC	p.L256F	SLC39A4_uc003zcm.1_5'Flank|SLC39A4_uc003zcn.2_5'Flank|SLC39A4_uc003zco.2_5'UTR|SLC39A4_uc003zcp.2_Missense_Mutation_p.L231F	NM_130849	NP_570901	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter),	256	Extracellular (Potential).					cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			GAGCTGATGAGGGGCACAGGG	0.667													5	44					0	0	0.000602	0	0
ZNF250	58500	broad.mit.edu	37	8	146107318	146107318	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr8:146107318G>A	uc003zeq.3	-	6	1382	c.1265C>T	c.(1264-1266)CCC>CTC	p.P422L	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Missense_Mutation_p.P417L|ZNF250_uc010mgg.2_Missense_Mutation_p.P417L	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		GCATGCATAGGGCTTTTCCTC	0.562													6	30					0	0	0.001168	0	0
FOXD4	2298	broad.mit.edu	37	9	117475	117475	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:117475G>A	uc003zfz.2	-	1	943	c.645C>T	c.(643-645)TTC>TTT	p.F215F		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	215	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CAGGTAGAGGGAAGGGGTGGG	0.706													15	127					0	0	0.006122	0	0
DMRT1	1761	broad.mit.edu	37	9	847141	847141	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:847141C>T	uc003zgv.2	+	2	685	c.536C>T	c.(535-537)TCA>TTA	p.S179L	DMRT1_uc003zgu.1_Missense_Mutation_p.S179L	NM_021951	NP_068770	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor	179					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		ACTGCAGCTTCAGGTAATCTG	0.597													4	17					0	0	0.000602	0	0
SMARCA2	6595	broad.mit.edu	37	9	2076262	2076262	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:2076262G>A	uc003zhc.2	+	13	2068	c.1969G>A	c.(1969-1971)GAA>AAA	p.E657K	SMARCA2_uc003zhd.2_Missense_Mutation_p.E657K|SMARCA2_uc010mha.2_Missense_Mutation_p.E648K	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	657					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GCAGGAAACCGAAGAGAAAAT	0.378													5	55					0	0	0.003080	0	0
RFX3	5991	broad.mit.edu	37	9	3270456	3270456	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:3270456G>A	uc003zhr.2	-	12	1584	c.1272C>T	c.(1270-1272)ATC>ATT	p.I424I	RFX3_uc010mhd.2_Silent_p.I424I|RFX3_uc003zhs.1_Silent_p.I424I	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	424					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		TCCATTTCAGGATAGACTCAT	0.418													6	28					0	0	0.001984	0	0
PTPRD	5789	broad.mit.edu	37	9	8389358	8389358	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:8389358C>T	uc003zkk.2	-	36	4971	c.4260G>A	c.(4258-4260)AGG>AGA	p.R1420R	PTPRD_uc003zkp.2_Silent_p.R1014R|PTPRD_uc003zkq.2_Silent_p.R1013R|PTPRD_uc003zkr.2_Silent_p.R1004R|PTPRD_uc003zks.2_Silent_p.R1013R|PTPRD_uc003zkl.2_Silent_p.R1411R|PTPRD_uc003zkm.2_Silent_p.R1407R|PTPRD_uc003zkn.2_Silent_p.R1009R|PTPRD_uc003zko.2_Silent_p.R1010R	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1420	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CATTTTGCTTCCTATACCCAT	0.448										TSP Lung(15;0.13)			10	77					0	0	0.008291	0	0
PTPRD	5789	broad.mit.edu	37	9	8499749	8499749	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:8499749C>T	uc003zkk.2	-	24	2931	c.2220G>A	c.(2218-2220)CAG>CAA	p.Q740Q	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Silent_p.Q740Q|PTPRD_uc003zkm.2_Silent_p.Q727Q|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	740	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCTGGCCATGCTGTTTATTGG	0.507										TSP Lung(15;0.13)			8	70					0	0	0.008291	0	0
PTPRD	5789	broad.mit.edu	37	9	8524997	8524997	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:8524997C>G	uc003zkk.2	-	17	1318	c.607G>C	c.(607-609)GGA>CGA	p.G203R	PTPRD_uc003zkp.2_Missense_Mutation_p.G203R|PTPRD_uc003zkq.2_Missense_Mutation_p.G203R|PTPRD_uc003zkr.2_Missense_Mutation_p.G197R|PTPRD_uc003zks.2_Missense_Mutation_p.G197R|PTPRD_uc003zkl.2_Missense_Mutation_p.G203R|PTPRD_uc003zkm.2_Missense_Mutation_p.G194R|PTPRD_uc003zkn.2_Missense_Mutation_p.G203R|PTPRD_uc003zko.2_Missense_Mutation_p.G200R	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	203	Extracellular (Potential).|Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCATATTTTCCTTGGTCAGAC	0.343										TSP Lung(15;0.13)			14	119					0	0	0.003163	0	0
CER1	9350	broad.mit.edu	37	9	14720209	14720209	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:14720209G>A	uc003zlj.2	-	2	728	c.683C>T	c.(682-684)TCC>TTC	p.S228F		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	228	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		CTTGATCACGGAGGAAAGTTC	0.547													7	39					0	0	0.004482	0	0
FREM1	158326	broad.mit.edu	37	9	14848671	14848671	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:14848671C>T	uc003zlm.2	-	7	1843	c.1253G>A	c.(1252-1254)TGG>TAG	p.W418*	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	418	CSPG 2.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		ACCTGTATTCCAGGATACACG	0.363													5	35					0	0	0.001984	0	0
PSIP1	11168	broad.mit.edu	37	9	15486016	15486016	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:15486016C>T	uc003zlv.3	-	6	774	c.444G>A	c.(442-444)GGG>GGA	p.G148G	PSIP1_uc003zlw.3_Silent_p.G148G|PSIP1_uc003zlz.3_Silent_p.G148G|PSIP1_uc003zma.3_Silent_p.G148G|PSIP1_uc003zly.2_Silent_p.G148G	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	148	Nuclear localization signal.				initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TTCTCTTTCTCCCCCTTCTGG	0.348													12	118					0	0	0.002450	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18888042	18888042	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:18888042G>A	uc003zne.3	+	24	4589	c.4462_splice	c.e24+1	p.D1488_splice	ADAMTSL1_uc003znf.3_Splice_Site_p.D189_splice	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		GTGATCCAAGGTAAGAAACCC	0.473													4	19					0	0	0.000602	0	0
IFNB1	3456	broad.mit.edu	37	9	21077465	21077465	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:21077465C>T	uc003zok.2	-	1	479	c.404G>A	c.(403-405)GGA>GAA	p.G135E		NM_002176	NP_002167	P01574	IFNB_HUMAN	interferon, beta 1, fibroblast precursor	135					activation of caspase activity|B cell proliferation|blood coagulation|cellular response to exogenous dsRNA|defense response to virus|induction of apoptosis|natural killer cell activation|negative regulation of cell proliferation|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of viral genome replication|negative regulation of viral transcription|negative regulation of virion penetration into host cell|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|regulation of MHC class I biosynthetic process|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding|transcription corepressor activity			ovary(1)|breast(1)|kidney(1)	3				GBM - Glioblastoma multiforme(5;7.45e-142)|Lung(24;2.42e-17)|LUSC - Lung squamous cell carcinoma(38;7.17e-11)	Interferon beta-1a(DB00060)|Interferon beta-1b(DB00068)	CATGAGTTTTCCCCTGGTGAA	0.443													12	105					0	0	0.010729	0	0
Unknown	0	broad.mit.edu	37	9	21278309	21278309	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:21278309G>A	uc003zou.1	-	1		c.254C>T								Messenger RNA for human leukocyte (alpha) interferon.																		TTGTCTAAAAGGGTCGCATCC	0.463													4	29					0	0	0.009096	0	0
IFNA8	3445	broad.mit.edu	37	9	21409494	21409494	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:21409494G>A	uc003zpc.1	+	1	349	c.319G>A	c.(319-321)GAA>AAA	p.E107K		NM_002170	NP_002161	P32881	IFNA8_HUMAN	interferon, alpha 8 precursor	107					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		CCTTCTAGATGAATTCTACAT	0.507													9	37					0	0	0.004482	0	0
MTAP	4507	broad.mit.edu	37	9	21837992	21837992	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:21837992T>G	uc003zph.2	+	5	546	c.433T>G	c.(433-435)TGC>GGC	p.C145G	MTAP_uc003zpi.1_Intron|MTAP_uc010mit.2_RNA|MTAP_uc011lnk.1_Missense_Mutation_p.C162G|MTAP_uc011lnl.1_Missense_Mutation_p.C78G	NM_002451	NP_002442	Q13126	MTAP_HUMAN	5'-methylthioadenosine phosphorylase	145					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity			central_nervous_system(1)	1		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	TGAGCCGTTTTGCCCCAAAAC	0.473													35	250					0	0	0.003271	0	0
DMRTA1	63951	broad.mit.edu	37	9	22451124	22451124	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:22451124C>T	uc003zpp.1	+	2	954	c.729C>T	c.(727-729)TCC>TCT	p.S243S		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	243					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		TCTCCAAATCCCATCAGCTTT	0.398													4	30					0	0	0.000602	0	0
PLAA	9373	broad.mit.edu	37	9	26910388	26910388	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:26910388G>A	uc003zqd.2	-	12	2030	c.1605C>T	c.(1603-1605)TTC>TTT	p.F535F	PLAA_uc003zqe.2_Silent_p.F535F	NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	535	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		CTTTTTTAGGGAAATAAATAT	0.318													5	42					0	0	0.004482	0	0
PLAA	9373	broad.mit.edu	37	9	26919513	26919513	+	Silent	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:26919513A>T	uc003zqd.2	-	9	1637	c.1212T>A	c.(1210-1212)GTT>GTA	p.V404V	PLAA_uc003zqe.2_Silent_p.V404V	NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	404	PFU.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		CAATTGAGAAAACATAATCAA	0.313													8	126					0	0	0.003080	0	0
TAF1L	138474	broad.mit.edu	37	9	32634114	32634114	+	Silent	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:32634114G>T	uc003zrg.1	-	1	1554	c.1464C>A	c.(1462-1464)CCC>CCA	p.P488P	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	488					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CATTGTCAATGGGAAAAATGG	0.473													11	85					0.000673444	0.000725214	0.008291	1	0
CNTFR	1271	broad.mit.edu	37	9	34556355	34556355	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:34556355C>T	uc003zup.1	-	7	947	c.666G>A	c.(664-666)CTG>CTA	p.L222L	CNTFR_uc003zuq.1_Silent_p.L222L	NM_147164	NP_671693	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	222	Fibronectin type-III 2.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			ovary(3)|central_nervous_system(1)|skin(1)	5	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		ACGTCACCTCCAGCCGGCGAG	0.572													5	30					0	0	0.000602	0	0
GALT	2592	broad.mit.edu	37	9	34647828	34647828	+	Splice_Site	SNP	G	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:34647828G>C	uc003zve.2	+	5	445	c.378_splice	c.e5-1	p.C126_splice	GALT_uc003zvf.2_Splice_Site_p.S17_splice|GALT_uc003zvg.2_5'UTR|GALT_uc003zvh.2_Splice_Site_p.C78_splice|GALT_uc011lop.1_Splice_Site_p.C78_splice|IL11RA_uc003zvi.2_5'Flank	NM_000155	NP_000146	P07902	GALT_HUMAN	galactose-1-phosphate uridylyltransferase						galactose catabolic process	cytosol	UDP-glucose:hexose-1-phosphate uridylyltransferase activity|zinc ion binding				0	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		TCACCACCCAGTAAGGTCATG	0.567									Galactosemia				4	58					0	0	0.001168	0	0
KIAA1045	23349	broad.mit.edu	37	9	34972408	34972408	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:34972408G>A	uc003zvq.2	+	3	622	c.444G>A	c.(442-444)AGG>AGA	p.R148R	KIAA1045_uc003zvr.2_Silent_p.R148R	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	148	PHD-type.						calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			TCCCGTGCAGGGTCTGCACCA	0.562													10	105					0	0	0.006214	0	0
RUSC2	9853	broad.mit.edu	37	9	35560433	35560433	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:35560433G>A	uc003zww.2	+	10	4051	c.3796G>A	c.(3796-3798)GGG>AGG	p.G1266R	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.G1266R	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1266						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GGCCCGAGGTGGGCAGGCCGG	0.483													5	50					0	0	0.001168	0	0
TPM2	7169	broad.mit.edu	37	9	35685461	35685461	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:35685461G>A	uc003zxq.2	-	4	701	c.462C>T	c.(460-462)ATC>ATT	p.I154I	TPM2_uc003zxr.2_Silent_p.I154I|TPM2_uc003zxs.2_Silent_p.I154I|TPM2_uc010mkz.2_Silent_p.I154I|TPM2_uc011lpa.1_Silent_p.I154I	NM_213674	NP_998839	P07951	TPM2_HUMAN	tropomyosin 2 (beta) isoform 2	154	By similarity.				muscle filament sliding|regulation of ATPase activity	cytosol|muscle thin filament tropomyosin	actin binding|structural constituent of muscle			ovary(1)	1	all_epithelial(49;0.121)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AATCCTCAGCGATGTGCTTGG	0.552													15	69					0	0	0.004007	0	0
NPR2	4882	broad.mit.edu	37	9	35802729	35802729	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:35802729G>A	uc003zyd.2	+	12	1816	c.1816G>A	c.(1816-1818)GAT>AAT	p.D606N	NPR2_uc010mlb.2_Intron	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	606	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CACTTACCAGGATATTCTAGA	0.443													4	47					0	0	0.001984	0	0
C9orf128	392307	broad.mit.edu	37	9	35826156	35826156	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:35826156C>T	uc010mlc.2	-	2	288	c.3G>A	c.(1-3)ATG>ATA	p.M1I	C9orf128_uc003zyj.2_RNA|C9orf128_uc011lpg.1_Missense_Mutation_p.M1I	NM_001012446	NP_001012448	A6H8Z2	CI128_HUMAN	hypothetical protein LOC392307	1											0	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			CATGTGCTTCCATCTAGTGGT	0.507											OREG0019180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	54					0	0	0.001168	0	0
TMEM8B	51754	broad.mit.edu	37	9	35853186	35853186	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:35853186G>A	uc003zym.2	+	13	2030	c.1015G>A	c.(1015-1017)GAC>AAC	p.D339N	TMEM8B_uc003zyo.2_Missense_Mutation_p.D339N	NM_001042589	NP_001036054	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B isoform a	339	Extracellular (Potential).				cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			ovary(1)	1						TCTGCAGCTTGACCGACATGG	0.602													16	92					0	0	0.004990	0	0
CCIN	881	broad.mit.edu	37	9	36169518	36169518	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:36169518G>A	uc003zzb.3	+	1	130	c.19G>A	c.(19-21)GAG>AAG	p.E7K		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	7					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			GGAATTCACGGAGAAAAACTA	0.493													8	25					0	0	0.006214	0	0
FRMPD1	22844	broad.mit.edu	37	9	37707488	37707488	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:37707488G>A	uc004aag.1	+	3	221	c.177G>A	c.(175-177)AAG>AAA	p.K59K	FRMPD1_uc004aah.1_Silent_p.K59K	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	59	PDZ.					cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		ACACAGTAAAGATAGACAAAG	0.517													5	71					0	0	0.001168	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39085752	39085752	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:39085752G>A	uc004abi.2	-	21	3662	c.3423C>T	c.(3421-3423)CTC>CTT	p.L1141L	CNTNAP3_uc004abj.2_Silent_p.L1060L|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_3'UTR	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	1141	Laminin G-like 4.|Extracellular (Potential).				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTCCCAATATGAGAGATTTGA	0.408													16	108					0	0	0.004990	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39103800	39103800	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:39103800G>A	uc004abi.2	-	16	2716	c.2477C>T	c.(2476-2478)TCC>TTC	p.S826F	CNTNAP3_uc004abj.2_Missense_Mutation_p.S825F|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Missense_Mutation_p.S826F	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	826	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CACCCCGGAGGAAACTGTGGT	0.478													5	27					0	0	0.001984	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39178162	39178162	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:39178162A>T	uc004abi.2	-	5	973	c.734T>A	c.(733-735)CTT>CAT	p.L245H	CNTNAP3_uc004abj.2_Missense_Mutation_p.L245H|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Missense_Mutation_p.L245H|CNTNAP3_uc011lqs.1_Missense_Mutation_p.L245H|CNTNAP3_uc004abl.1_Missense_Mutation_p.L157H	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	245	Extracellular (Potential).|Laminin G-like 1.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACCTGAATTAAGAAAAAAGAC	0.294													5	70					0	0	0.000602	0	0
FAM75A2	642265	broad.mit.edu	37	9	39361018	39361018	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:39361018G>A	uc004abm.2	+	4	3285	c.3256G>A	c.(3256-3258)GAG>AAG	p.E1086K		NM_001040065	NP_001035154	Q5RGS2	F75A2_HUMAN	hypothetical protein LOC642265	1086						integral to membrane					0				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACTGGTGCACGAGGAGCCCAG	0.542													45	168					0	0	0.014410	0	0
ZNF658	26149	broad.mit.edu	37	9	40772423	40772423	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:40772423G>A	uc004abs.2	-	5	3004	c.2852C>T	c.(2851-2853)TCA>TTA	p.S951L	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.S951L	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	951	C2H2-type 21.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCTGAGGGTTGAATTATGGGC	0.428													15	121					0	0	0.003163	0	0
ZNF658	26149	broad.mit.edu	37	9	40772600	40772600	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:40772600G>A	uc004abs.2	-	5	2827	c.2675C>T	c.(2674-2676)TCC>TTC	p.S892F	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.S892F	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	892	C2H2-type 19; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TGATGTCTTGGAGAAAGTCTT	0.448													7	99					0	0	0.003080	0	0
ZNF658	26149	broad.mit.edu	37	9	40774080	40774080	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:40774080G>A	uc004abs.2	-	5	1347	c.1195C>T	c.(1195-1197)CTC>TTC	p.L399F	ZNF658_uc010mmm.1_Missense_Mutation_p.L399F|ZNF658_uc010mmn.1_Missense_Mutation_p.L399F	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	399	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TGCTGAATGAGGTGTGCTTTC	0.403													17	174					0	0	0.006122	0	0
FAM75A5	727905	broad.mit.edu	37	9	65506468	65506468	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:65506468C>T	uc004adx.3	-	4	1121	c.1092G>A	c.(1090-1092)CGG>CGA	p.R364R		NM_015667	NP_056482	Q5VU36	F75A5_HUMAN	hypothetical protein LOC26165	364						integral to membrane					0						TAGCCAAATTCCGCAAATAAT	0.433													58	197					0	0	0.014410	0	0
LOC442421	442421	broad.mit.edu	37	9	66499792	66499792	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:66499792C>T	uc004aee.1	+	1	602	c.602C>T	c.(601-603)TCG>TTG	p.S201L	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						CTGTGCAAGTCGCGCAAGGAG	0.592													5	61					0	0	0.000602	0	0
ANKRD20A4	728747	broad.mit.edu	37	9	69420422	69420422	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:69420422G>A	uc004afn.2	+	13	1424	c.1312G>A	c.(1312-1314)GAT>AAT	p.D438N		NM_001098805	NP_001092275	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	438	Potential.										0						GGAAGAGCATGATAGGTAAGC	0.299													8	138					0	0	0.010729	0	0
FOXD4L5	653427	broad.mit.edu	37	9	70177738	70177738	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:70177738G>T	uc010moc.2	-	1	1078	c.246C>A	c.(244-246)GAC>GAA	p.D82E		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	82					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						ACTCTGAGGGGTCACTCGGGC	0.692													25	231					5.61819e-17	6.09517e-17	0.005443	1	0
PRKACG	5568	broad.mit.edu	37	9	71628097	71628097	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:71628097G>A	uc004agy.2	-	1	943	c.912C>T	c.(910-912)ATC>ATT	p.I304I		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	304	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						CATAGATGGCGATCCAGCTGG	0.572													13	50					0	0	0.013537	0	0
MAMDC2	256691	broad.mit.edu	37	9	72746444	72746444	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:72746444G>A	uc004ahm.2	+	7	1527	c.910G>A	c.(910-912)GAA>AAA	p.E304K	MAMDC2_uc004ahn.2_RNA	NM_153267	NP_694999	Q7Z304	MAMC2_HUMAN	MAM domain containing 2 precursor	304	MAM 2.					endoplasmic reticulum|membrane				central_nervous_system(1)|pancreas(1)	2						GGTTATTTTTGAAGTTGCTTT	0.393													12	61					0	0	0.010729	0	0
KLF9	687	broad.mit.edu	37	9	73027957	73027957	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:73027957G>A	uc004aht.2	-	1	1617	c.323C>T	c.(322-324)TCC>TTC	p.S108F		NM_001206	NP_001197	Q13886	KLF9_HUMAN	Kruppel-like factor 9	108	Asp/Glu-rich (acidic).				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CGGGCTGTGGGAAGGACTCGA	0.632													8	72					0	0	0.003080	0	0
TMEM2	23670	broad.mit.edu	37	9	74365121	74365122	+	Missense_Mutation	DNP	GG	TC	TC			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:74365121_74365122GG>TC	uc011lsa.1	-	2	708_709	c.168_169CC>GA	c.(166-171)GACCGG>GAGAGG	p.D56E	TMEM2_uc010mos.2_Missense_Mutation_p.D56E|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	56						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AAGGTTGCCCGGTCTTCTCGTC	0.465													6	97					0	0	0.004672	0	0
TRPM6	140803	broad.mit.edu	37	9	77427271	77427271	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:77427271C>T	uc004ajl.1	-	12	1625	c.1387G>A	c.(1387-1389)GGA>AGA	p.G463R	TRPM6_uc004ajk.1_Missense_Mutation_p.G458R|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.G463R|TRPM6_uc010mpd.1_Missense_Mutation_p.G463R|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	463	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						AGGTTCACTCCATATTCTATT	0.418													6	51					0	0	0.001168	0	0
TRPM6	140803	broad.mit.edu	37	9	77457121	77457121	+	Silent	SNP	C	T	T	rs141159434	by1000genomes	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:77457121C>T	uc004ajl.1	-	4	529	c.291G>A	c.(289-291)ACG>ACA	p.T97T	TRPM6_uc004ajk.1_Silent_p.T92T|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Silent_p.T97T|TRPM6_uc010mpd.1_Silent_p.T97T|TRPM6_uc010mpe.1_Silent_p.T97T|TRPM6_uc004ajn.1_Silent_p.T97T	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	97	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GGAAATTAATCGTGCCAAAAG	0.358													7	56					0	0	0.004482	0	0
PCSK5	5125	broad.mit.edu	37	9	78547359	78547359	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:78547359C>T	uc004ajz.2	+	2	795	c.257C>T	c.(256-258)TCG>TTG	p.S86L	PCSK5_uc004ajy.2_Missense_Mutation_p.S86L|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	86					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						TCAGTTATCTCGAGCAGAGGG	0.453													8	49					0	0	0.004482	0	0
PCSK5	5125	broad.mit.edu	37	9	78710846	78710846	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:78710846G>A	uc004ajz.2	+	8	1473	c.935G>A	c.(934-936)GGA>GAA	p.G312E	PCSK5_uc004ajy.2_Missense_Mutation_p.G312E|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	312	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						TGGGCATCTGGAAATGGTGGA	0.493													7	96					0	0	0.003080	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323128	79323128	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:79323128C>T	uc010mpk.2	-	8	4186	c.4062G>A	c.(4060-4062)GGG>GGA	p.G1354G		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1354					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity	p.G1354G(1)			0						TTTCAGAAATCCCTGAGGCAT	0.498													4	43					0	0	0.009096	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324378	79324378	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:79324378C>T	uc010mpk.2	-	8	2936	c.2812G>A	c.(2812-2814)GAA>AAA	p.E938K		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	938					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AAGGAATCTTCCCAAGGAACT	0.423													20	155					0	0	0.008871	0	0
GNA14	9630	broad.mit.edu	37	9	80144078	80144078	+	Silent	SNP	C	T	T	rs140008129		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:80144078C>T	uc004aku.2	-	2	739	c.216G>A	c.(214-216)ACG>ACA	p.T72T		NM_004297	NP_004288	O95837	GNA14_HUMAN	G alpha 14	72					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(2)	2						AAACCAGCTTCGTGAACCCCT	0.448													31	231					0	0	0.013726	0	0
GNAQ	2776	broad.mit.edu	37	9	80430643	80430643	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:80430643G>A	uc004akw.2	-	3	406	c.365C>T	c.(364-366)TCT>TTT	p.S122F	GNAQ_uc011lso.1_5'UTR	NM_002072	NP_002063	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein),	122					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			eye(136)|skin(44)|meninges(11)|ovary(1)|kidney(1)	193						CTCAAAAGCAGACACCTTCTC	0.353			Mis		uveal melanoma								6	35					0	0	0.001984	0	0
FLJ46321	389763	broad.mit.edu	37	9	84606371	84606371	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:84606371C>T	uc004amn.2	+	4	1033	c.986C>T	c.(985-987)TCT>TTT	p.S329F		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	329						integral to membrane					0						GAAATGTTATCTCTAGGTGGC	0.488													14	103					0	0	0.002450	0	0
NTRK2	4915	broad.mit.edu	37	9	87359893	87359893	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:87359893G>A	uc004aoa.1	+	13	2139	c.1201G>A	c.(1201-1203)GGA>AGA	p.G401R	NTRK2_uc004anv.1_Missense_Mutation_p.G388R|NTRK2_uc004any.1_Missense_Mutation_p.G401R|NTRK2_uc004anz.1_Missense_Mutation_p.G401R|NTRK2_uc011lsz.1_Missense_Mutation_p.G401R|NTRK2_uc011lta.1_Missense_Mutation_p.G401R|NTRK2_uc004aob.1_Missense_Mutation_p.G401R|NTRK2_uc011ltb.1_Missense_Mutation_p.G245R	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	401	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						TTAAGATTATGGAACTGCAGC	0.478										TSP Lung(25;0.17)			7	97					0	0	0.003080	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88307707	88307707	+	Silent	SNP	G	A	A	rs142829279		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:88307707G>A	uc011ltd.1	-	2	87	c.54C>T	c.(52-54)ATC>ATT	p.I18I	AGTPBP1_uc010mqc.2_Silent_p.I18I|AGTPBP1_uc011lte.1_Silent_p.I70I	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	18					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						GGAGTCCTACGATCCTAGAAT	0.383													4	34					0	0	0.000602	0	0
CTSL3	392360	broad.mit.edu	37	9	90387866	90387866	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:90387866G>A	uc004apm.1	+	1	37	c.31G>A	c.(31-33)GAA>AAA	p.E11K		NR_027917				RecName: Full=Putative cathepsin L-like protein 3;          Short=Cathepsin L-like protein; AltName: Full=HCTSL-s;											ovary(1)	1						GGAATACAGGGAAGGGAAACA	0.473													5	40					0	0	0.001984	0	0
FAM75C1	441452	broad.mit.edu	37	9	90535625	90535625	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:90535625C>T	uc010mqi.2	+	4	832	c.803C>T	c.(802-804)CCA>CTA	p.P268L	FAM75C1_uc004apq.3_Missense_Mutation_p.P251L	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						AGCTTGTCTCCACGTGAGGAT	0.572													10	93					0	0	0.013537	0	0
FAM75C1	441452	broad.mit.edu	37	9	90538261	90538261	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:90538261C>T	uc010mqi.2	+	4	3468	c.3439C>T	c.(3439-3441)CGG>TGG	p.R1147W	FAM75C1_uc004apq.3_Missense_Mutation_p.R1130W	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GAAAAGTGTCCGGTGCAACAA	0.557													7	88					0	0	0.004482	0	0
SEMA4D	10507	broad.mit.edu	37	9	91978697	91978697	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:91978697C>T	uc011ltm.1	-	19	2623	c.2051G>A	c.(2050-2052)GGG>GAG	p.G684E	SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aql.2_RNA|SEMA4D_uc004aqm.2_RNA	NM_001142287	NP_001135759	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 2	Error:Variant_position_missing_in_Q92854_after_alignment					anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						AGTCTTGTTCCCTGCTGAGGA	0.527													3	21					0	0	0.009096	0	0
ASPN	54829	broad.mit.edu	37	9	95228677	95228677	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:95228677C>T	uc004ase.1	-	4	808	c.564G>A	c.(562-564)AAG>AAA	p.K188K	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ASPN_uc010mqy.1_Silent_p.K188K	NM_017680	NP_060150	Q9BXN1	ASPN_HUMAN	asporin precursor	188	Interaction with TGFB1 (By similarity).|LRR 4.				bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding				0						TGAATGTGTCCTTTTGTATTT	0.318													5	36					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	9	99884366	99884366	+	RNA	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:99884366G>A	uc004aww.1	-	2		c.1428C>T								Homo sapiens cDNA FLJ34611 fis, clone KIDNE2014112.																		GGCCACAGAGGACAGTGCCCC	0.592													3	12					0	0	0.004672	0	0
C9orf156	51531	broad.mit.edu	37	9	100672574	100672574	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:100672574G>A	uc004axv.1	-	4	811	c.734C>T	c.(733-735)CCT>CTT	p.P245L	C9orf156_uc004axw.1_Missense_Mutation_p.P142L|C9orf156_uc004axx.1_Missense_Mutation_p.P99L|C9orf156_uc010msq.1_Missense_Mutation_p.P142L	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	245					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				CCTGTGCATAGGAAATGCTTG	0.453													14	123					0	0	0.004007	0	0
ANKS6	203286	broad.mit.edu	37	9	101536359	101536359	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:101536359G>A	uc004ayu.2	-	9	1642	c.1621C>T	c.(1621-1623)CGA>TGA	p.R541*	ANKS6_uc004ayt.2_Nonsense_Mutation_p.R240*|ANKS6_uc004ayv.1_Nonsense_Mutation_p.R3*|ANKS6_uc004ayw.1_Nonsense_Mutation_p.R123*|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	541										ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				GCTCCGTTTCGAAGCTGAAAA	0.557													4	24					0	0	0.009096	0	0
BAAT	570	broad.mit.edu	37	9	104133271	104133271	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:104133271C>T	uc010mtd.2	-	2	525	c.416G>A	c.(415-417)CGA>CAA	p.R139Q	BAAT_uc004bbd.3_Missense_Mutation_p.R139Q	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	139					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	AACCTTAATTCGTGTGACACC	0.433													8	62					0	0	0.006214	0	0
ALDOB	229	broad.mit.edu	37	9	104193085	104193085	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:104193085C>T	uc004bbk.2	-	2	167	c.85G>A	c.(85-87)GGG>AGG	p.G29R		NM_000035	NP_000026	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	29					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GCCAGGATCCCCTTTCCATTG	0.443													6	35					0	0	0.008291	0	0
C9orf125	84302	broad.mit.edu	37	9	104238679	104238679	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:104238679G>A	uc004bbm.2	-	2	1018	c.696C>T	c.(694-696)TTC>TTT	p.F232F	uc004bbl.1_5'Flank	NM_032342	NP_115718	Q9BRR3	CI125_HUMAN	hypothetical protein LOC84302	232						integral to membrane					0		Acute lymphoblastic leukemia(62;0.0527)				GTGGCTCAGAGAAGCGAGCCC	0.542													5	42					0	0	0.001984	0	0
RNF20	56254	broad.mit.edu	37	9	104312959	104312959	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:104312959C>T	uc004bbn.2	+	10	1254	c.1164C>T	c.(1162-1164)TTC>TTT	p.F388F		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	388					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		AGTCACAGTTCTCCGTCTTGT	0.502													8	113					0	0	0.003080	0	0
PPP3R2	5535	broad.mit.edu	37	9	104356976	104356976	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:104356976G>A	uc004bbr.2	-	1	308	c.237C>T	c.(235-237)ATC>ATT	p.I79I	GRIN3A_uc004bbp.1_Intron|GRIN3A_uc004bbq.1_Intron|PPP3R2_uc010mtf.1_Intron	NM_147180	NP_671709	Q96LZ3	CANB2_HUMAN	protein phosphatase 3 regulatory subunit B, beta	76	EF-hand 2.						calcium ion binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	AGGTCCCCAGGATGAATTCCT	0.552													9	62					0	0	0.006214	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432421	104432421	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:104432421G>A	uc004bbp.1	-	3	2874	c.2273C>T	c.(2272-2274)TCC>TTC	p.S758F	GRIN3A_uc004bbq.1_Missense_Mutation_p.S758F	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	758	Helical; (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CGTGTATGTGGAAAGGCAAAA	0.428													6	51					0	0	0.001168	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432470	104432470	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:104432470C>T	uc004bbp.1	-	3	2825	c.2224G>A	c.(2224-2226)GGA>AGA	p.G742R	GRIN3A_uc004bbq.1_Missense_Mutation_p.G742R	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	742	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	AGAAACCTTCCAGTCCAACAT	0.423													15	36					0	0	0.004007	0	0
OR13C3	138803	broad.mit.edu	37	9	107298321	107298321	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:107298321C>T	uc004bcb.1	-	1	774	c.774G>A	c.(772-774)ATG>ATA	p.M258I		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	258	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TGGCTGAATTCATTTGCAAGA	0.413													7	66					0	0	0.004482	0	0
OR13C3	138803	broad.mit.edu	37	9	107298727	107298727	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:107298727G>A	uc004bcb.1	-	1	368	c.368C>T	c.(367-369)TCC>TTC	p.S123F		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	123	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TCCAGAGAAGGAAATGTTTCT	0.443													9	58					0	0	0.004482	0	0
OR13C5	138799	broad.mit.edu	37	9	107361157	107361157	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:107361157C>T	uc011lvp.1	-	1	538	c.538G>A	c.(538-540)GAA>AAA	p.E180K		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GCTAGAATTTCACAGGTGAAA	0.423													19	74					0	0	0.007413	0	0
OR13C5	138799	broad.mit.edu	37	9	107361685	107361685	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:107361685C>T	uc011lvp.1	-	1	10	c.10G>A	c.(10-12)GAA>AAA	p.E4K		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	4	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GTGTGGTTTTCCCATTCCATT	0.363													4	50					0	0	0.000602	0	0
OR13D1	286365	broad.mit.edu	37	9	107457422	107457422	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:107457422G>A	uc011lvs.1	+	1	720	c.720G>A	c.(718-720)GTG>GTA	p.V240V		NM_001004484	NP_001004484	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D,	240	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTTCACTGGTGATTCTTCTAC	0.353													5	61					0	0	0.000602	0	0
FKTN	2218	broad.mit.edu	37	9	108370212	108370212	+	Nonsense_Mutation	SNP	G	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:108370212G>T	uc004bcr.2	+	7	976	c.760G>T	c.(760-762)GAA>TAA	p.E254*	FKTN_uc011lvx.1_Nonsense_Mutation_p.E254*|FKTN_uc004bcs.2_Nonsense_Mutation_p.E254*|FKTN_uc011lvy.1_Nonsense_Mutation_p.E254*|FKTN_uc010mtm.2_Nonsense_Mutation_p.E122*	NM_001079802	NP_001073270	O75072	FKTN_HUMAN	fukutin	254	Lumenal (Potential).				muscle organ development|negative regulation of cell proliferation|negative regulation of JNK cascade|nervous system development|regulation of protein glycosylation	cis-Golgi network|endoplasmic reticulum|extracellular space|Golgi membrane|integral to membrane|nucleus	transferase activity			breast(2)|ovary(1)	3						TAGGTATAAAGAAGCTCGAGC	0.353													7	34					2.7689e-08	3.00009e-08	0.001984	1	0
ZNF462	58499	broad.mit.edu	37	9	109686529	109686529	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:109686529C>T	uc004bcz.2	+	3	625	c.336C>T	c.(334-336)TTC>TTT	p.F112F	ZNF462_uc010mto.2_5'UTR|ZNF462_uc004bda.2_5'UTR	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	112	C2H2-type 2.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						AATGCAAGTTCTGTGTACGCT	0.478													4	45					0	0	0.000602	0	0
RAD23B	5887	broad.mit.edu	37	9	110086240	110086240	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:110086240C>T	uc004bde.2	+	8	1254	c.887C>T	c.(886-888)CCT>CTT	p.P296L	RAD23B_uc011lwa.1_Missense_Mutation_p.P296L|RAD23B_uc011lwb.1_Missense_Mutation_p.P275L	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	296	STI1.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						CAGCAGAATCCTTCCTTGCTT	0.378								Direct_reversal_of_damage|NER					5	84					0	0	0.000602	0	0
PTPN3	5774	broad.mit.edu	37	9	112185014	112185014	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:112185014G>A	uc004bed.2	-	13	1232	c.1120C>T	c.(1120-1122)CCC>TCC	p.P374S	PTPN3_uc004beb.2_Missense_Mutation_p.P243S|PTPN3_uc004bec.2_Intron|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Intron|PTPN3_uc011lwh.1_Intron|PTPN3_uc011lwe.1_Missense_Mutation_p.P87S|PTPN3_uc011lwf.1_Intron	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	374					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						GGAGTAATGGGAGGGGAACGA	0.413													9	61					0	0	0.008291	0	0
SVEP1	79987	broad.mit.edu	37	9	113231315	113231315	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:113231315G>A	uc010mtz.2	-	17	3402	c.3065C>T	c.(3064-3066)TCC>TTC	p.S1022F	SVEP1_uc010mua.1_Missense_Mutation_p.S1022F	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1022					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ATCTTGATAGGATCCGATCCG	0.413													13	55					0	0	0.002450	0	0
KIAA0368	23392	broad.mit.edu	37	9	114135473	114135473	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:114135473T>C	uc004bfe.1	-	42	4847	c.4847A>G	c.(4846-4848)AAT>AGT	p.N1616S		NM_001080398	NP_001073867			KIAA0368 protein												0						ATACCACCCATTGAGCTTCTG	0.333													11	139					0	0	0.003163	0	0
ZNF483	158399	broad.mit.edu	37	9	114296571	114296571	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:114296571C>T	uc004bff.2	+	5	883	c.659C>T	c.(658-660)TCC>TTC	p.S220F	ZNF483_uc011lwq.1_Missense_Mutation_p.S220F|ZNF483_uc004bfg.2_Missense_Mutation_p.S220F	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	220	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						GAGTTGATTTCCCAGCTAAAG	0.383													12	87					0	0	0.003163	0	0
ZNF483	158399	broad.mit.edu	37	9	114304908	114304908	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:114304908T>C	uc004bff.2	+	6	1917	c.1693T>C	c.(1693-1695)TCC>CCC	p.S565P	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	565	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						TCATAGCTCATCCCTTTCCAA	0.403													3	50					0	0	0.004672	0	0
KIAA1958	158405	broad.mit.edu	37	9	115336381	115336381	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:115336381C>T	uc004bgf.1	+	2	196	c.21C>T	c.(19-21)ACC>ACT	p.T7T	KIAA1958_uc011lwx.1_Silent_p.T7T	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	7										skin(1)	1						GTCTTCATACCTCATCTGAGA	0.433													10	44					0	0	0.008291	0	0
ZNF883	169834	broad.mit.edu	37	9	115760022	115760022	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:115760022C>T	uc011lwy.1	-	5	1757	c.518G>A	c.(517-519)GGA>GAA	p.G173E		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	173	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGAATGAATTCCCTGATGTTC	0.408													4	58					0	0	0.001168	0	0
PRPF4	9128	broad.mit.edu	37	9	116038899	116038899	+	Silent	SNP	T	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:116038899T>C	uc004bgx.2	+	2	152	c.102T>C	c.(100-102)AGT>AGC	p.S34S	FKBP15_uc010muu.1_5'Flank|CDC26_uc004bgw.2_5'Flank|PRPF4_uc004bgy.2_Silent_p.S33S	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	34						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						ATTATGGAAGTTTGGAAGAGA	0.438													5	71					0	0	0.000602	0	0
PAPPA	5069	broad.mit.edu	37	9	118950190	118950190	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:118950190C>T	uc004bjn.2	+	2	1554	c.1173C>T	c.(1171-1173)ATC>ATT	p.I391I	PAPPA_uc011lxp.1_Silent_p.I184I|PAPPA_uc011lxq.1_Silent_p.I184I	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	391	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						AATACAACATCTCCTGGGAGC	0.562													8	32					0	0	0.004482	0	0
PAPPA	5069	broad.mit.edu	37	9	119093563	119093563	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:119093563C>T	uc004bjn.2	+	11	3569	c.3188C>T	c.(3187-3189)TCC>TTC	p.S1063F	PAPPA_uc011lxp.1_Missense_Mutation_p.S758F|PAPPA_uc011lxq.1_Missense_Mutation_p.S438F	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1063					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GAAGGCATTTCCCAGCATGCC	0.443													14	61					0	0	0.003163	0	0
ASTN2	23245	broad.mit.edu	37	9	119903696	119903696	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:119903696G>A	uc004bjs.1	-	4	1178	c.1077C>T	c.(1075-1077)TTC>TTT	p.F359F	ASTN2_uc004bjr.1_Silent_p.F359F|ASTN2_uc004bjt.1_Intron	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	359	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TGTTAGCGCGGAAACTCTCCT	0.592													6	36					0	0	0.001984	0	0
TLR4	7099	broad.mit.edu	37	9	120475736	120475736	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:120475736C>T	uc004bjz.2	+	3	1621	c.1330C>T	c.(1330-1332)CTA>TTA	p.L444L	TLR4_uc004bka.2_Silent_p.L404L|TLR4_uc004bkb.2_Silent_p.L244L	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	444	LRR 13.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTCAGTATTCCTATCACTCAG	0.383													10	54					0	0	0.006214	0	0
TLR4	7099	broad.mit.edu	37	9	120475982	120475982	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:120475982A>T	uc004bjz.2	+	3	1867	c.1576A>T	c.(1576-1578)AAT>TAT	p.N526Y	TLR4_uc004bka.2_Missense_Mutation_p.N486Y|TLR4_uc004bkb.2_Missense_Mutation_p.N326Y	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	526	LRR 17.|Extracellular (Potential).			N->A: Abolishes LPS-response and prevents the cell surface expression.	activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TCAGGTACTAAATATGAGCCA	0.428													5	43					0	0	0.000602	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123308024	123308024	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:123308024G>A	uc004bkf.2	-	5	532	c.351C>T	c.(349-351)CTC>CTT	p.L117L	CDK5RAP2_uc004bkg.2_Silent_p.L117L|CDK5RAP2_uc011lxw.1_5'UTR|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_5'UTR|CDK5RAP2_uc011lya.1_5'UTR|CDK5RAP2_uc004bkh.1_Silent_p.L117L	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	117					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CTCTCTCCTGGAGTTCCCGCT	0.443													18	86					0	0	0.004990	0	0
TRAF1	7185	broad.mit.edu	37	9	123673706	123673706	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:123673706G>A	uc004bku.1	-	6	1363	c.791C>T	c.(790-792)TCC>TTC	p.S264F	TRAF1_uc011lyg.1_Missense_Mutation_p.S142F|TRAF1_uc010mvl.1_Missense_Mutation_p.S264F	NM_005658	NP_005649	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	264					apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			skin(2)|ovary(1)	3						GCCATCGAAGGAGGCCTCCTC	0.612													7	30					0	0	0.001984	0	0
C5	727	broad.mit.edu	37	9	123725049	123725049	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:123725049G>A	uc004bkv.2	-	36	4434	c.4404C>T	c.(4402-4404)CCC>CCT	p.P1468P		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1468					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	AATCACTGGAGGGAATCTGTT	0.348													12	49					0	0	0.013537	0	0
RBM18	92400	broad.mit.edu	37	9	125014198	125014198	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:125014198G>A	uc004bma.2	-	3	334	c.168C>T	c.(166-168)TTC>TTT	p.F56F	RBM18_uc004blz.2_RNA|RBM18_uc010mvy.2_RNA|RBM18_uc011lyp.1_Intron	NM_033117	NP_149108	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	56	RRM.						nucleotide binding|RNA binding				0						TGTGGAAGAGGAAGTCAAACT	0.428													8	58					0	0	0.003080	0	0
OR1J2	26740	broad.mit.edu	37	9	125273119	125273119	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:125273119C>T	uc004bmj.1	+	4	894	c.39C>T	c.(37-39)CTC>CTT	p.L13L	OR1J2_uc011lyv.1_Silent_p.L13L	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|pancreas(1)|breast(1)	5						CCGAGTTCCTCCTTCTGGGCC	0.547													12	88					0	0	0.001855	0	0
OR1B1	347169	broad.mit.edu	37	9	125391313	125391313	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:125391313G>A	uc011lyz.1	-	1	502	c.502C>T	c.(502-504)CTT>TTT	p.L168F		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTCCAGCAAAGAGGCAGGACG	0.527													3	22					0	0	0.004672	0	0
OR1L3	26735	broad.mit.edu	37	9	125437891	125437891	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:125437891C>T	uc011lzb.1	+	1	483	c.483C>T	c.(481-483)CTC>CTT	p.L161L		NM_001005234	NP_001005234	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TACATGTCCTCCTGGTGAATC	0.443													13	150					0	0	0.004007	0	0
OR1L3	26735	broad.mit.edu	37	9	125437994	125437994	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:125437994G>A	uc011lzb.1	+	1	586	c.586G>A	c.(586-588)GAA>AAA	p.E196K		NM_001005234	NP_001005234	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTTTGTCAATGAAATTGTGGC	0.433													17	109					0	0	0.004990	0	0
OR5C1	392391	broad.mit.edu	37	9	125551761	125551761	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:125551761G>A	uc011lzd.1	+	1	550	c.550G>A	c.(550-552)GAT>AAT	p.D184N		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						CTTCTTCTGCGATATCCCTCC	0.562													4	25					0	0	0.009096	0	0
NR5A1	2516	broad.mit.edu	37	9	127262788	127262788	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:127262788C>T	uc004boo.1	-	4	638	c.451G>A	c.(451-453)GGC>AGC	p.G151S		NM_004959	NP_004950	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	151					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						GCGGCCAGGCCCTTGGGCTCA	0.741													3	12					0	0	0.000602	0	0
NR6A1	2649	broad.mit.edu	37	9	127289121	127289121	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:127289121G>A	uc004bor.1	-	8	1316	c.1138C>T	c.(1138-1140)CAT>TAT	p.H380Y	NR6A1_uc004boq.1_Missense_Mutation_p.H375Y|NR6A1_uc010mwq.1_Missense_Mutation_p.H376Y	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	380					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						TTTAGCTGATGGAACTTGTGA	0.478													22	61					0	0	0.003330	0	0
WDR38	401551	broad.mit.edu	37	9	127618151	127618151	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:127618151A>C	uc004box.2	+	4	375	c.319A>C	c.(319-321)AGT>CGT	p.S107R	WDR38_uc011lzn.1_Missense_Mutation_p.S96R|WDR38_uc011lzo.1_Missense_Mutation_p.S107R|WDR38_uc011lzp.1_Missense_Mutation_p.S58R	NM_001045476	NP_001038941	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	107	WD 3.										0						TCACCAACGGAGTGTGGAGAC	0.627											OREG0019485	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	77					0	0	0.001168	0	0
GARNL3	84253	broad.mit.edu	37	9	130152978	130152978	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:130152978C>T	uc011mae.1	+	27	3203	c.2802C>T	c.(2800-2802)CCC>CCT	p.P934P	GARNL3_uc011mad.1_Silent_p.P912P|GARNL3_uc010mxi.2_Silent_p.P164P	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	934					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AATCAAAACCCCGGAAGCGGT	0.572													10	72					0	0	0.006214	0	0
SH2D3C	10044	broad.mit.edu	37	9	130507109	130507109	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:130507109C>T	uc004bsc.2	-	7	1676	c.1534G>A	c.(1534-1536)GAG>AAG	p.E512K	SH2D3C_uc010mxo.2_Missense_Mutation_p.E352K|SH2D3C_uc004bry.2_Missense_Mutation_p.E354K|SH2D3C_uc004brz.3_Missense_Mutation_p.E158K|SH2D3C_uc011mak.1_Missense_Mutation_p.E158K|SH2D3C_uc004bsa.2_Missense_Mutation_p.E355K|SH2D3C_uc004bsb.2_Missense_Mutation_p.E444K	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	512					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						CTGGAGGTCTCAGTCGCTGCC	0.632													17	105					0	0	0.006122	0	0
CERCAM	51148	broad.mit.edu	37	9	131186488	131186488	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:131186488G>A	uc004buz.3	+	4	896	c.498G>A	c.(496-498)GTG>GTA	p.V166V	CERCAM_uc004buy.1_Silent_p.V88V|CERCAM_uc010mxz.2_Silent_p.V88V|CERCAM_uc010mya.1_Silent_p.V7V	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	166					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						GGCTTCCAGTGGTGGCCCCAA	0.597													11	103					0	0	0.013537	0	0
DOLK	22845	broad.mit.edu	37	9	131708265	131708265	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:131708265G>A	uc004bwr.2	-	1	1748	c.1318C>T	c.(1318-1320)CCC>TCC	p.P440S	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	dolichol kinase	440	Helical; (Potential).				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity				0						CCGGCATAGGGGACGAGGGCC	0.602													4	56					0	0	0.009096	0	0
PRRX2	51450	broad.mit.edu	37	9	132484531	132484531	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:132484531C>T	uc004byh.2	+	4	889	c.662C>T	c.(661-663)CCC>CTC	p.P221L		NM_016307	NP_057391	Q99811	PRRX2_HUMAN	paired related homeobox 2	221						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		Ovarian(14;0.00556)				AGCTCAGGCCCCGCAACCCCA	0.632													7	25					0	0	0.003080	0	0
NUP214	8021	broad.mit.edu	37	9	134067664	134067664	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:134067664C>T	uc004cag.2	+	27	3755	c.3644C>T	c.(3643-3645)TCA>TTA	p.S1215L	NUP214_uc004cah.2_Missense_Mutation_p.S1205L|NUP214_uc004cai.2_Missense_Mutation_p.S645L|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.S41L|NUP214_uc010mzf.2_Missense_Mutation_p.S513L|NUP214_uc011mcf.1_Intron|NUP214_uc010mzh.1_5'UTR|NUP214_uc010mzi.1_5'UTR	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1215	Pro/Ser/Thr-rich.|11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		AAGCCTTTCTCATTTTCTCCA	0.338			T	DEK|SET|ABL1	AML|T-ALL								7	36					0	0	0.001984	0	0
C9orf9	11092	broad.mit.edu	37	9	135759337	135759337	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:135759337G>A	uc004cbx.1	+	2	114	c.3G>A	c.(1-3)ATG>ATA	p.M1I	C9orf9_uc004cby.1_Missense_Mutation_p.M1I|C9orf9_uc004cbz.1_Missense_Mutation_p.M1I	NM_018956	NP_061829	Q96E40	CI009_HUMAN	Rsb-66 protein	1								p.?(1)			0				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|GBM - Glioblastoma multiforme(294;4.84e-07)|Epithelial(140;1.28e-06)		GGAAGACAATGAATGAGGTGA	0.542													6	49					0	0	0.001984	0	0
GFI1B	8328	broad.mit.edu	37	9	135864500	135864500	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:135864500G>A	uc004ccg.2	+	5	714	c.563G>A	c.(562-564)GGG>GAG	p.G188E	GFI1B_uc010mzy.2_Intron	NM_004188	NP_004179	Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription	188	Mediates interaction with GATA1.|Interaction with ARIH2.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		TCCCATAGTGGGACCCGGCCC	0.672													5	25					0	0	0.001168	0	0
CEL	1056	broad.mit.edu	37	9	135945962	135945962	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:135945962C>T	uc010naa.1	+	10	1426	c.1410C>T	c.(1408-1410)TTC>TTT	p.F470F		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	467					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GGAAGCCCTTCGCCACCCCCA	0.582													43	438					0	0	0.014410	0	0
DBH	1621	broad.mit.edu	37	9	136505108	136505108	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:136505108C>T	uc004cel.2	+	2	489	c.480C>T	c.(478-480)CTC>CTT	p.L160L		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	160	DOMON.|Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	AGGATTACCTCATTGAAGTAA	0.587													4	24					0	0	0.000602	0	0
SARDH	1757	broad.mit.edu	37	9	136573515	136573515	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:136573515C>T	uc004cep.3	-	11	1498	c.1364G>A	c.(1363-1365)TGG>TAG	p.W455*	SARDH_uc004ceo.2_Nonsense_Mutation_p.W455*|SARDH_uc011mdn.1_Nonsense_Mutation_p.W455*|SARDH_uc011mdo.1_Nonsense_Mutation_p.W287*	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	455					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CTCTCGGATCCAGCGGGGGTG	0.657													10	77					0	0	0.002450	0	0
SARDH	1757	broad.mit.edu	37	9	136596581	136596581	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:136596581G>A	uc004cep.3	-	4	670	c.536C>T	c.(535-537)TCC>TTC	p.S179F	SARDH_uc004ceo.2_Missense_Mutation_p.S179F|SARDH_uc011mdn.1_Missense_Mutation_p.S179F|SARDH_uc011mdo.1_Missense_Mutation_p.S11F	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	179					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CAGCACATGGGATTCCACACC	0.627													6	30					0	0	0.003080	0	0
FCN1	2219	broad.mit.edu	37	9	137808284	137808284	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:137808284C>T	uc004cfi.2	-	2	219	c.127G>A	c.(127-129)GGC>AGC	p.G43S		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	43					opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TTGTCAGAGCCCTCCAGGCCC	0.642													8	128					0	0	0.003080	0	0
GLT6D1	360203	broad.mit.edu	37	9	138517988	138517988	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:138517988C>T	uc010nbd.1	-	4	438	c.184G>A	c.(184-186)GAC>AAC	p.D62N		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	62	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		ACCCGCCTGTCGAAAGTCCCT	0.507													7	41					0	0	0.001984	0	0
SNAPC4	6621	broad.mit.edu	37	9	139286445	139286445	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:139286445G>A	uc004chh.2	-	9	933	c.924C>T	c.(922-924)ATC>ATT	p.I308I		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	308	HTH myb-type 1.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GTGCAGCCGCGATCGCCTGCA	0.657													8	64					0	0	0.003080	0	0
SEC16A	9919	broad.mit.edu	37	9	139372053	139372053	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:139372053G>A	uc004chx.2	-	3	324	c.15C>T	c.(13-15)CCC>CCT	p.P5P	SEC16A_uc004chv.3_5'Flank|SEC16A_uc004chw.2_Silent_p.P5P|SEC16A_uc010nbn.2_Silent_p.P5P|SEC16A_uc010nbo.1_Silent_p.P5P	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1979	Required for interaction with SEC23A.|Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GGACCGTCTGGGGCGGTGGCT	0.547													3	10					0	0	0.004672	0	0
ABCA2	20	broad.mit.edu	37	9	139913674	139913674	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:139913674G>A	uc011mem.1	-	10	1655	c.1507C>T	c.(1507-1509)CTG>TTG	p.L503L	ABCA2_uc011mel.1_Silent_p.L504L|ABCA2_uc004ckl.1_Silent_p.L434L|ABCA2_uc004ckm.1_Silent_p.L534L|ABCA2_uc004ckn.1_5'Flank|ABCA2_uc004cko.1_Silent_p.L280L	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	503					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCCTGCTCCAGGAAGCTGCGG	0.652													4	33					0	0	0.009096	0	0
C9orf139	401563	broad.mit.edu	37	9	139929401	139929401	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:139929401A>T	uc004ckp.1	+	3	1982	c.468A>T	c.(466-468)GAA>GAT	p.E156D	FUT7_uc004ckq.2_5'Flank	NM_207511	NP_997394	Q6ZV77	CI139_HUMAN	hypothetical protein LOC401563	156											0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		TTTGCCCAGAAATGGGTCAGA	0.622													6	65					0	0	0.001984	0	0
NDOR1	27158	broad.mit.edu	37	9	140110460	140110460	+	Silent	SNP	C	T	T	rs151243461		TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:140110460C>T	uc004clw.2	+	12	1656	c.1545C>T	c.(1543-1545)TCC>TCT	p.S515S	NDOR1_uc004clx.2_Silent_p.S515S|NDOR1_uc011mes.1_Silent_p.S508S|NDOR1_uc004cly.2_Silent_p.S481S	NM_014434	NP_055249	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	515					cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CTGCCTTCTCCCGGGAACAGG	0.607													12	90					0	0	0.013537	0	0
EHMT1	79813	broad.mit.edu	37	9	140622819	140622819	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:140622819C>T	uc011mfc.1	+	4	698	c.661C>T	c.(661-663)CCC>TCC	p.P221S	EHMT1_uc004coa.2_Missense_Mutation_p.P221S|EHMT1_uc004cob.1_Missense_Mutation_p.P190S	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	221					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CAGTAAAGATCCCAGAGAAGT	0.413													7	60					0	0	0.003080	0	0
CACNA1B	774	broad.mit.edu	37	9	140968471	140968471	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:140968471C>T	uc004cog.2	+	33	4955	c.4810C>T	c.(4810-4812)CTG>TTG	p.L1604L	CACNA1B_uc004coi.2_Silent_p.L816L|CACNA1B_uc004cok.1_5'Flank|CACNA1B_uc010ncp.1_5'Flank	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1604	IV.|Helical; Name=S5 of repeat IV; (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTACGTGTGTCTGCTCATTGC	0.627													7	70					0	0	0.008291	0	0
PPP2R3B	28227	broad.mit.edu	37	X	295189	295189	+	Missense_Mutation	SNP	C	G	G	rs143890778	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:295189C>G	uc004cpg.2	-	13	1842	c.1641G>C	c.(1639-1641)CAG>CAC	p.Q547H	PPP2R3B_uc004cpf.2_Missense_Mutation_p.Q148H	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	547					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGAAGGGCCTCTGGGCCAGCG	0.706													3	24					0	0	0.004672	0	0
ARSF	416	broad.mit.edu	37	X	3019200	3019200	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:3019200G>A	uc004cre.1	+	8	1261	c.1040G>A	c.(1039-1041)GGA>GAA	p.G347E	ARSF_uc004crf.1_Missense_Mutation_p.G347E	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	347						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCAGATCACGGAGGGCATTTG	0.433													10	49					0	0	0.006214	0	0
MXRA5	25878	broad.mit.edu	37	X	3240451	3240451	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:3240451G>A	uc004crg.3	-	5	3432	c.3275C>T	c.(3274-3276)TCC>TTC	p.S1092F		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1092						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CAAAGTGATGGATTTGCTCTC	0.493													6	32					0	0	0.001168	0	0
MXRA5	25878	broad.mit.edu	37	X	3241047	3241047	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:3241047C>T	uc004crg.3	-	5	2836	c.2679G>A	c.(2677-2679)GAG>GAA	p.E893E		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	893						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCTCAGTCTTCTCGGAAAGGT	0.478													9	52					0	0	0.004482	0	0
MSL3	10943	broad.mit.edu	37	X	11790277	11790277	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:11790277C>T	uc004cuw.2	+	11	1389	c.1284C>T	c.(1282-1284)GTC>GTT	p.V428V	MSL3_uc004cux.2_Silent_p.V369V|MSL3_uc011mig.1_Silent_p.V279V|MSL3_uc011mih.1_Silent_p.V416V|MSL3_uc004cuy.2_Silent_p.V262V	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	428					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTTTCCAGGTCCTCTCCTGGA	0.448													14	35					0	0	0.003163	0	0
FRMPD4	9758	broad.mit.edu	37	X	12627910	12627910	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:12627910C>T	uc004cuz.1	+	3	735	c.229C>T	c.(229-231)CGG>TGG	p.R77W	FRMPD4_uc011mij.1_Missense_Mutation_p.R69W	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	77					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TCCGGCTCCTCGGAAGGTGGA	0.532													12	32					0	0	0.013537	0	0
SCML2	10389	broad.mit.edu	37	X	18283813	18283813	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:18283813G>A	uc004cyl.2	-	8	997	c.840C>T	c.(838-840)GTC>GTT	p.V280V	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Silent_p.V280V|SCML2_uc011miz.1_Silent_p.V214V|SCML2_uc010nfc.2_Silent_p.V16V	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	280					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					TTGATCTCCTGACCTGCTGTG	0.418													15	51					0	0	0.004007	0	0
PHKA2	5256	broad.mit.edu	37	X	18969319	18969319	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:18969319G>A	uc004cyv.3	-	4	787	c.357C>T	c.(355-357)GCC>GCT	p.A119A	PHKA2_uc010nfh.1_Intron|PHKA2_uc010nfi.1_Silent_p.A61A	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	119					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					TGCCACAGGTGGCGGTGTTGT	0.617													25	24					0	0	0.003954	0	0
ACOT9	23597	broad.mit.edu	37	X	23723117	23723117	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:23723117G>A	uc004dap.2	-	13	1219	c.1073C>T	c.(1072-1074)TCT>TTT	p.S358F	ACOT9_uc004dan.2_Missense_Mutation_p.S108F|ACOT9_uc004dao.2_Missense_Mutation_p.S367F|ACOT9_uc004daq.2_Missense_Mutation_p.S316F|ACOT9_uc004dar.2_Missense_Mutation_p.S298F|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Missense_Mutation_p.S298F	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	358					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						TACCTGTGAAGAAAGAAAGAG	0.403													6	30					0	0	0.001168	0	0
APOO	79135	broad.mit.edu	37	X	23897068	23897068	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:23897068G>A	uc004dax.2	-	3	432	c.201C>T	c.(199-201)CTC>CTT	p.L67L	APOO_uc004daw.2_RNA|APOO_uc004day.3_RNA	NM_024122	NP_077027	Q9BUR5	APOO_HUMAN	apolipoprotein O precursor	67					lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle					0						AATAGTGTCGGAGCTGTGAGA	0.463													20	21					0	0	0.012319	0	0
ZFX	7543	broad.mit.edu	37	X	24228975	24228975	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:24228975C>T	uc004dbf.2	+	9	2158	c.1900C>T	c.(1900-1902)CAG>TAG	p.Q634*	ZFX_uc004dbe.2_3'UTR|ZFX_uc011mjv.1_Nonsense_Mutation_p.Q673*|ZFX_uc010nfz.2_Nonsense_Mutation_p.Q290*	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	634	C2H2-type 8.			Missing (in Ref. 5).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2						CAAAACACACCAGTGTTTGCA	0.423													16	25					0	0	0.006122	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157208	26157208	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:26157208G>A	uc004dbq.1	+	2	293	c.106G>A	c.(106-108)GAG>AAG	p.E36K		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	36							protein binding			central_nervous_system(1)	1						GGCAGAAGGAGAGTCACCCTC	0.577													6	10					0	0	0.001984	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839807	27839807	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:27839807G>A	uc004dbw.2	+	3	611	c.384G>A	c.(382-384)ATG>ATA	p.M128I		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	128	MAGE.									lung(1)|breast(1)|central_nervous_system(1)	3						AGTACCAAATGAAAGAGCCCA	0.443													4	8					0	0	0.009096	0	0
DMD	1756	broad.mit.edu	37	X	32519904	32519904	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:32519904G>A	uc004dda.1	-	19	2592	c.2348C>T	c.(2347-2349)TCA>TTA	p.S783L	DMD_uc004dcz.2_Missense_Mutation_p.S660L|DMD_uc004dcy.1_Missense_Mutation_p.S779L|DMD_uc004ddb.1_Missense_Mutation_p.S775L|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	783	Spectrin 4.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGCCTGAGCTGATCTGCTGGC	0.408													9	8					0	0	0.004482	0	0
FAM47C	442444	broad.mit.edu	37	X	37028490	37028490	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:37028490G>A	uc004ddl.1	+	1	2021	c.2007G>A	c.(2005-2007)GAG>GAA	p.E669E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	669										ovary(3)	3						TCCCCCCGGAGCCCCCCGAGA	0.642													8	16					0	0	0.008291	0	0
LANCL3	347404	broad.mit.edu	37	X	37526710	37526710	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:37526710G>A	uc011mkd.1	+	4	1373	c.1071G>A	c.(1069-1071)ACG>ACA	p.T357T	LANCL3_uc004ddp.1_Silent_p.T357T	NM_198511	NP_940913	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3	357							catalytic activity				0						ACCGGCTCACGGGAAACTCTA	0.423													9	11					0	0	0.004482	0	0
MAOB	4129	broad.mit.edu	37	X	43634452	43634452	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:43634452A>G	uc004dfz.3	-	12	1381	c.1205T>C	c.(1204-1206)TTC>TCC	p.F402S	MAOB_uc011mkx.1_Intron|MAOB_uc011mky.1_Missense_Mutation_p.F386S	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	402	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	CCCAGGGGGGAAATAAGTTGT	0.448													5	4					0	0	0.001168	0	0
MAOB	4129	broad.mit.edu	37	X	43698125	43698125	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:43698125G>A	uc004dfz.3	-	3	444	c.268C>T	c.(268-270)CAC>TAC	p.H90Y	MAOB_uc011mkx.1_Missense_Mutation_p.H74Y|MAOB_uc011mky.1_Missense_Mutation_p.H74Y|MAOB_uc010nhj.2_Missense_Mutation_p.H90Y	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	90	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	TTTACATGGTGGATCAGACGC	0.423													12	35					0	0	0.013537	0	0
EFHC2	80258	broad.mit.edu	37	X	44120372	44120372	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:44120372C>T	uc004dgb.3	-	5	645	c.555G>A	c.(553-555)GTG>GTA	p.V185V		NM_025184	NP_079460	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	185							calcium ion binding			breast(3)|ovary(2)|central_nervous_system(1)	6						CTGGGGGATTCACTTTGACCC	0.403													7	40					0	0	0.004482	0	0
WAS	7454	broad.mit.edu	37	X	48545242	48545242	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:48545242G>A	uc004dkm.3	+	7	689	c.632G>A	c.(631-633)CGA>CAA	p.R211Q		NM_000377	NP_000368	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome protein	211					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			ovary(1)	1		all_lung(315;1.27e-10)				ACGAGTTCACGATACCGTGGG	0.572			Mis|N|F|S			lymphoma			Wiskott-Aldrich_syndrome				6	16					0	0	0.001984	0	0
PAGE4	9506	broad.mit.edu	37	X	49597195	49597195	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:49597195C>T	uc004don.1	+	4	313	c.234C>T	c.(232-234)GGC>GGT	p.G78G		NM_007003	NP_008934	O60829	GAGC1_HUMAN	G antigen, family C, 1	78											0	Ovarian(276;0.236)					GTGGAGATGGCTCTGATGTAA	0.383													4	20					0	0	0.009096	0	0
PHF8	23133	broad.mit.edu	37	X	54048696	54048696	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:54048696C>A	uc004dsu.2	-	4	470	c.397G>T	c.(397-399)GAC>TAC	p.D133Y	PHF8_uc004dst.2_Missense_Mutation_p.D97Y|PHF8_uc004dsw.2_Missense_Mutation_p.D97Y|PHF8_uc004dsy.2_Missense_Mutation_p.D97Y	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	133					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						CCTCACCTGTCAAAAGTCCTA	0.562													12	28					3.07112e-06	3.31788e-06	0.010729	1	0
WNK3	65267	broad.mit.edu	37	X	54224978	54224978	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:54224978G>A	uc004dtd.1	-	23	5450	c.5011C>T	c.(5011-5013)CCT>TCT	p.P1671S	WNK3_uc004dtc.1_Missense_Mutation_p.P1728S|uc004dtb.1_5'Flank	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1671					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						AATGGCCCAGGAAATGAAGGG	0.493													7	12					0	0	0.003080	0	0
FAAH2	158584	broad.mit.edu	37	X	57405152	57405152	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:57405152C>T	uc004dvc.2	+	6	960	c.811C>T	c.(811-813)CCT>TCT	p.P271S		NM_174912	NP_777572	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	271						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3						GTGCACTGGTCCTATGTGCCG	0.498										HNSCC(52;0.14)			11	21					0	0	0.013537	0	0
HEPH	9843	broad.mit.edu	37	X	65480099	65480099	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:65480099G>A	uc011moz.1	+	19	3263	c.3203G>A	c.(3202-3204)CGA>CAA	p.R1068Q	HEPH_uc004dwn.2_Missense_Mutation_p.R1068Q|HEPH_uc004dwo.2_Missense_Mutation_p.R798Q|HEPH_uc010nkr.2_Missense_Mutation_p.R876Q|HEPH_uc011mpa.1_Missense_Mutation_p.R1068Q	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1065	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						GTTTTTTCTCGAACAGGTAAG	0.473													5	13					0	0	0.000602	0	0
AR	367	broad.mit.edu	37	X	66765853	66765853	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:66765853G>A	uc004dwu.1	+	1	1980	c.865G>A	c.(865-867)GAA>AAA	p.E289K	AR_uc011mpd.1_Missense_Mutation_p.E289K|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.E289K	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	287	Modulating.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CCCATTGGCCGAATGCAAAGG	0.562									Androgen_Insensitivity_Syndrome				4	15					0	0	0.000602	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69424321	69424321	+	Missense_Mutation	SNP	G	A	A	rs147349994	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:69424321G>A	uc004dxx.1	+	6	911	c.814G>A	c.(814-816)GGA>AGA	p.G272R		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	272					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						CTTCACTCGCGGATCCTGGGG	0.502													9	34					0	0	0.004482	0	0
NAP1L2	4674	broad.mit.edu	37	X	72433980	72433980	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:72433980T>A	uc004ebi.2	-	1	705	c.349A>T	c.(349-351)AAG>TAG	p.K117*	NAP1L2_uc011mqj.1_5'UTR	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	117					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					GTTTGAAGCTTTTTAAGGGCT	0.388													12	21					0	0	0.010729	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961115	73961115	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:73961115C>T	uc004eby.2	-	3	3894	c.3277G>A	c.(3277-3279)GGA>AGA	p.G1093R		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1093					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTTAGTGTTCCTAGTGTCTTC	0.507													7	27					0	0	0.003080	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963455	73963455	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:73963455G>A	uc004eby.2	-	3	1554	c.937C>T	c.(937-939)CGA>TGA	p.R313*		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	313					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GATTCATATCGAATTTTCAGG	0.418													14	20					0	0	0.006122	0	0
ATRX	546	broad.mit.edu	37	X	76939723	76939723	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:76939723G>A	uc004ecp.3	-	9	1257	c.1025C>T	c.(1024-1026)TCT>TTT	p.S342F	ATRX_uc004ecq.3_Missense_Mutation_p.S304F|ATRX_uc004eco.3_Missense_Mutation_p.S127F|ATRX_uc004ecr.2_Missense_Mutation_p.S303F|ATRX_uc010nlx.1_Missense_Mutation_p.S342F|ATRX_uc010nly.1_Missense_Mutation_p.S287F	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	342					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TGCGGAATAAGAGTAGGTTAC	0.348			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						17	23					0	0	0.004007	0	0
P2RY10	27334	broad.mit.edu	37	X	78216634	78216634	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:78216634G>A	uc004ede.2	+	4	986	c.617G>A	c.(616-618)GGA>GAA	p.G206E	P2RY10_uc004edf.2_Missense_Mutation_p.G206E	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	206	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						GAGCTTGCAGGATTTGTGATC	0.458													9	17					0	0	0.004482	0	0
BRWD3	254065	broad.mit.edu	37	X	79932599	79932599	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:79932599G>A	uc004edt.2	-	41	5181	c.4918C>T	c.(4918-4920)CAT>TAT	p.H1640Y	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.H1236Y|BRWD3_uc004edp.2_Missense_Mutation_p.H1469Y|BRWD3_uc004edq.2_Missense_Mutation_p.H1236Y|BRWD3_uc010nmj.1_Missense_Mutation_p.H1236Y|BRWD3_uc004edr.2_Missense_Mutation_p.H1310Y|BRWD3_uc004eds.2_Missense_Mutation_p.H1236Y|BRWD3_uc004edu.2_Missense_Mutation_p.H1310Y|BRWD3_uc004edv.2_Missense_Mutation_p.H1236Y|BRWD3_uc004edw.2_Missense_Mutation_p.H1236Y|BRWD3_uc004edx.2_Missense_Mutation_p.H1236Y|BRWD3_uc004edy.2_Missense_Mutation_p.H1236Y|BRWD3_uc004edz.2_Missense_Mutation_p.H1310Y|BRWD3_uc004eea.2_Missense_Mutation_p.H1310Y|BRWD3_uc004eeb.2_Missense_Mutation_p.H1236Y|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1640										ovary(4)	4						CTATAATCATGGTCTCCATCT	0.403													19	59					0	0	0.014323	0	0
CYLC1	1538	broad.mit.edu	37	X	83126513	83126513	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:83126513C>T	uc004eei.1	+	3	133	c.112C>T	c.(112-114)CCC>TCC	p.P38S	CYLC1_uc004eeh.1_Missense_Mutation_p.P37S	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	38					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						TTTGACATTTCCCAAACCACT	0.299													4	14					0	0	0.000602	0	0
CHM	1121	broad.mit.edu	37	X	85218957	85218958	+	Missense_Mutation	DNP	GG	AC	AC			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:85218957_85218958GG>AC	uc004eet.2	-	5	444_445	c.414_415CC>GT	c.(412-417)TTCCTG>TTGTTG	p.F138L	CHM_uc011mqz.1_5'UTR	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	138					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				TCCGTAGGCAGGAAGGCAGAAT	0.47													9	18					0	0	0.004672	0	0
SRPX2	27286	broad.mit.edu	37	X	99917314	99917314	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:99917314C>T	uc004egb.2	+	4	785	c.305C>T	c.(304-306)TCG>TTG	p.S102L		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	102	Sushi 1.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						GGAAGGAGGTCGGTGCAATGC	0.552													14	50					0	0	0.004990	0	0
SRPX2	27286	broad.mit.edu	37	X	99919867	99919868	+	Missense_Mutation	DNP	GT	AG	AG			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:99919867_99919868GT>AG	uc004egb.2	+	5	932_933	c.452_453GT>AG	c.(451-453)AGT>AAG	p.S151K		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	151	Sushi 2.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						AGCTGTTCCAGTGGCTACCACC	0.52													3	9					0	0	0.004672	0	0
DRP2	1821	broad.mit.edu	37	X	100493979	100493979	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:100493979G>A	uc004egz.2	+	6	817	c.448G>A	c.(448-450)GAA>AAA	p.E150K	DRP2_uc011mrh.1_Missense_Mutation_p.E72K	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	150	Spectrin 1.				central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						GGCCTTTATGGAAGAAGTCAA	0.448													8	28					0	0	0.004482	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104984617	104984617	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:104984617G>A	uc004elz.1	+	8	1737	c.981G>A	c.(979-981)GCG>GCA	p.A327A		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	327	Ig-like C2-type 3.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						CTGACCTGGCGAATTATACCT	0.388													13	25					0	0	0.003163	0	0
SERPINA7	6906	broad.mit.edu	37	X	105277500	105277500	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:105277500C>T	uc004eme.1	-	4	1255	c.1239G>A	c.(1237-1239)ACG>ACA	p.T413T	SERPINA7_uc010npd.2_Silent_p.T413T	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	413					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	ACTACGCTTCCGTTGGGTTCA	0.393													11	79					0	0	0.008291	0	0
RNF128	79589	broad.mit.edu	37	X	106038899	106038899	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:106038899G>A	uc004eml.2	+	7	1493	c.1243G>A	c.(1243-1245)GAA>AAA	p.E415K	RNF128_uc004emk.2_Missense_Mutation_p.E389K	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	415						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						TGAAGAAGACGAAACTCCTAA	0.363													35	70					0	0	0.006999	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106116842	106116842	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:106116842C>T	uc004emo.2	+	21	3175	c.3010C>T	c.(3010-3012)CAT>TAT	p.H1004Y	MORC4_uc004emp.3_Intron	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	1004						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TAACTTATTTCATGAGGACCC	0.353													20	35					0	0	0.008871	0	0
MORC4	79710	broad.mit.edu	37	X	106184802	106184802	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:106184802G>A	uc004emu.3	-	17	2964	c.2721C>T	c.(2719-2721)CTC>CTT	p.L907L	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Missense_Mutation_p.P895S|MORC4_uc004emw.3_Missense_Mutation_p.P643S	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	907							ATP binding|zinc ion binding			ovary(1)	1						CCAAGTGAGGGAGGACAGAAG	0.522													9	18					0	0	0.006214	0	0
ATG4A	115201	broad.mit.edu	37	X	107381365	107381365	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:107381365C>T	uc004enr.2	+	9	881	c.758C>T	c.(757-759)TCT>TTT	p.S253F	ATG4A_uc004ent.2_Intron|ATG4A_uc004ens.2_Missense_Mutation_p.S169F|ATG4A_uc011msl.1_Intron|ATG4A_uc010npi.2_Intron|ATG4A_uc004enu.2_Missense_Mutation_p.S169F	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	253					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1						ATGCCACAGTCTTTAGGGGCA	0.453													17	60					0	0	0.010504	0	0
IRS4	8471	broad.mit.edu	37	X	107978024	107978024	+	Silent	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:107978024C>G	uc004eoc.2	-	1	1584	c.1551G>C	c.(1549-1551)TCG>TCC	p.S517S		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	517						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GGTTTCCTCCCGAGCTATGGC	0.597													18	58					0	0	0.010504	0	0
GUCY2F	2986	broad.mit.edu	37	X	108619172	108619172	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:108619172G>A	uc004eod.3	-	19	3559	c.3283C>T	c.(3283-3285)CAA>TAA	p.Q1095*	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	1095	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TTTCTTCTTTGGAAGGCTGCA	0.498													11	56					0	0	0.008291	0	0
RGAG1	57529	broad.mit.edu	37	X	109695723	109695723	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:109695723G>A	uc004eor.1	+	3	2124	c.1878G>A	c.(1876-1878)ACG>ACA	p.T626T	RGAG1_uc011msr.1_Silent_p.T626T	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	626										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CCTCAGGAACGATGTTCACGG	0.502													4	39					0	0	0.009096	0	0
CXorf61	203413	broad.mit.edu	37	X	115593162	115593162	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:115593162C>T	uc004eqj.1	-	2	208	c.88G>A	c.(88-90)GAA>AAA	p.E30K		NM_001017978	NP_001017978	Q5H943	KKLC1_HUMAN	chromosome X open reading frame 61	30	Extracellular (Potential).					integral to membrane|plasma membrane					0						GATGACATTTCGCCAGTGTTT	0.383													11	21					0	0	0.010729	0	0
IL13RA1	3597	broad.mit.edu	37	X	117900492	117900492	+	Splice_Site	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:117900492G>A	uc004eqs.2	+	7	872	c.829_splice	c.e7-1	p.V277_splice	IL13RA1_uc004eqt.1_Splice_Site_p.V277_splice	NM_001560	NP_001551	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1 precursor							interleukin-13 receptor complex	cytokine receptor activity				0						ttattttCAAGGTCCAAGAGG	0.333													4	18					0	0	0.009096	0	0
LONRF3	79836	broad.mit.edu	37	X	118148314	118148314	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:118148314C>T	uc004eqw.2	+	10	2150	c.2119C>T	c.(2119-2121)CCT>TCT	p.P707S	LONRF3_uc004eqx.2_Missense_Mutation_p.P666S|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_Missense_Mutation_p.P451S	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	707	Lon.				proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						AGACGCCGATCCTCAGGTATA	0.433													4	31					0	0	0.009096	0	0
ODZ1	10178	broad.mit.edu	37	X	123518361	123518361	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:123518361C>T	uc004euj.2	-	29	6463	c.6399G>A	c.(6397-6399)ATG>ATA	p.M2133I	ODZ1_uc011muj.1_Missense_Mutation_p.M2139I|ODZ1_uc010nqy.2_Missense_Mutation_p.M2140I	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2133	Extracellular (Potential).|YD 16.			MVICD -> HGNMC (in Ref. 1; AAF04723).	immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CACATATTACCATGCGGCCCA	0.393													16	38					0	0	0.006122	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185093	127185093	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:127185093C>T	uc004eum.2	-	1	1290	c.1093G>A	c.(1093-1095)GAG>AAG	p.E365K		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	365						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						GTCCCATACTCCTTGAAGTCT	0.473													26	47					0	0	0.007291	0	0
ZDHHC9	51114	broad.mit.edu	37	X	128975808	128975808	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:128975808G>A	uc004euv.2	-	2	483	c.114C>T	c.(112-114)TTC>TTT	p.F38F	ZDHHC9_uc004euw.2_Silent_p.F38F|ZDHHC9_uc004eux.1_Silent_p.F38F|ZDHHC9_uc004euy.1_Intron	NM_001008222	NP_001008223	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC domain containing 9	38	Helical; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1						GGGTCAGGTAGAAAATGCCCT	0.498													12	43					0	0	0.013537	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130215768	130215768	+	Silent	SNP	C	T	T	rs150725005	byFrequency	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:130215768C>T	uc004evz.2	+	2	474	c.129C>T	c.(127-129)CCC>CCT	p.P43P	ARHGAP36_uc004ewa.2_Silent_p.P31P|ARHGAP36_uc004ewb.2_Silent_p.P12P|ARHGAP36_uc004ewc.2_5'Flank	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	43					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						GACACAACCCCGACCGCAGGA	0.552													12	74					0	0	0.001855	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130219889	130219889	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:130219889C>T	uc004evz.2	+	9	1452	c.1107C>T	c.(1105-1107)GTC>GTT	p.V369V	ARHGAP36_uc004ewa.2_Silent_p.V357V|ARHGAP36_uc004ewb.2_Silent_p.V338V|ARHGAP36_uc004ewc.2_Silent_p.V233V	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	369	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						TTGCCTAGGTCCCAGGCAACC	0.438													29	120					0	0	0.010818	0	0
IGSF1	3547	broad.mit.edu	37	X	130412580	130412580	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:130412580G>A	uc004ewd.2	-	12	2134	c.1896C>T	c.(1894-1896)ATC>ATT	p.I632I	IGSF1_uc004ewe.3_Silent_p.I626I|IGSF1_uc004ewf.2_Silent_p.I612I	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	632	Extracellular (Potential).|Ig-like C2-type 6.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GGCGAGTGGCGATCCACCCGG	0.617													7	29					0	0	0.001984	0	0
FRMD7	90167	broad.mit.edu	37	X	131212787	131212787	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:131212787C>T	uc004ewn.2	-	12	1436	c.1258G>A	c.(1258-1260)GAC>AAC	p.D420N	FRMD7_uc011muy.1_Missense_Mutation_p.D405N	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	420					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AAGACAGGGTCCATATAAATA	0.383													35	60					0	0	0.004289	0	0
USP26	83844	broad.mit.edu	37	X	132162210	132162210	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:132162210C>T	uc010nrm.1	-	6	509	c.39G>A	c.(37-39)GGG>GGA	p.G13G	USP26_uc011mvf.1_Silent_p.G13G	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	13					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					TCTTGCAGTTCCCTATTTGGA	0.358													4	36					0	0	0.001168	0	0
SAGE1	55511	broad.mit.edu	37	X	134991100	134991100	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:134991100G>A	uc004ezh.2	+	13	1686	c.1519G>A	c.(1519-1521)GAT>AAT	p.D507N	SAGE1_uc010nry.1_Missense_Mutation_p.D476N|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	507										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CATATCAAATGATGCACCACA	0.433													8	27					0	0	0.003080	0	0
GPR112	139378	broad.mit.edu	37	X	135405401	135405401	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:135405401C>T	uc004ezu.1	+	5	826	c.535C>T	c.(535-537)CCT>TCT	p.P179S	GPR112_uc010nsb.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	179	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GCGTAGCTTTCCTGGCAGCTT	0.448													22	36					0	0	0.003330	0	0
GPR112	139378	broad.mit.edu	37	X	135427103	135427103	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:135427103C>G	uc004ezu.1	+	6	1529	c.1238C>G	c.(1237-1239)TCT>TGT	p.S413C	GPR112_uc010nsb.1_Missense_Mutation_p.S208C|GPR112_uc010nsc.1_Missense_Mutation_p.S180C	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	413	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACATCTATGTCTACAACACCT	0.408													7	41					0	0	0.001984	0	0
GPR112	139378	broad.mit.edu	37	X	135427664	135427664	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:135427664C>T	uc004ezu.1	+	6	2090	c.1799C>T	c.(1798-1800)TCC>TTC	p.S600F	GPR112_uc010nsb.1_Missense_Mutation_p.S395F|GPR112_uc010nsc.1_Missense_Mutation_p.S367F	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	600	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACTATGCTTTCCTCCACAATC	0.458													7	20					0	0	0.003080	0	0
GPR112	139378	broad.mit.edu	37	X	135429806	135429806	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:135429806C>T	uc004ezu.1	+	6	4232	c.3941C>T	c.(3940-3942)TCG>TTG	p.S1314L	GPR112_uc010nsb.1_Missense_Mutation_p.S1109L|GPR112_uc010nsc.1_Missense_Mutation_p.S1081L	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1314	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CAAACACATTCGCCTTCAGAG	0.433													11	19					0	0	0.013537	0	0
GPR112	139378	broad.mit.edu	37	X	135455070	135455070	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:135455070G>A	uc004ezu.1	+	15	7914	c.7623G>A	c.(7621-7623)AGG>AGA	p.R2541R	GPR112_uc010nsb.1_Silent_p.R2336R	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2541	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GAATTCTGAGGATAATTGAGC	0.478													19	96					0	0	0.006122	0	0
F9	2158	broad.mit.edu	37	X	138633289	138633289	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:138633289C>T	uc004fas.1	+	6	618	c.589C>T	c.(589-591)CCT>TCT	p.P197S	F9_uc004fat.1_Missense_Mutation_p.P159S	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	197					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	GACTGTTTTTCCTGATGTGGA	0.388													7	33					0	0	0.003080	0	0
MAGEC2	51438	broad.mit.edu	37	X	141290960	141290960	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:141290960C>T	uc004fbu.1	-	3	1162	c.814G>A	c.(814-816)GAG>AAG	p.E272K		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	272	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GTGAGGAGCTCCCTAGGCTCC	0.542										HNSCC(46;0.14)			14	33					0	0	0.001855	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967308	142967308	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:142967308C>T	uc004fca.2	+	1	136	c.106C>T	c.(106-108)CAT>TAT	p.H36Y		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	36							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					CCGTTATTTTCATGTGGTCAT	0.498													7	57					0	0	0.003080	0	0
IDS	3423	broad.mit.edu	37	X	148579787	148579787	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:148579787C>T	uc011mxe.1	-	5	757	c.559G>A	c.(559-561)GAT>AAT	p.D187N	IDS_uc011mxf.1_Missense_Mutation_p.D97N|IDS_uc011mxg.1_5'UTR|IDS_uc010nsu.1_Intron|IDS_uc004fcw.3_5'UTR|IDS_uc011mxh.1_Missense_Mutation_p.D187N|IDS_uc011mxi.1_RNA	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	187						lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					TCCAGCACATCCACAGGGCAA	0.453													9	11					0	0	0.006214	0	0
PASD1	139135	broad.mit.edu	37	X	150840204	150840204	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:150840204C>T	uc004fev.3	+	13	1722	c.1390C>T	c.(1390-1392)CTC>TTC	p.L464F		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	464						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATCCAACTCTCTCAAAAACAC	0.463													6	41					0	0	0.001984	0	0
PRRG3	79057	broad.mit.edu	37	X	150869199	150869199	+	Silent	SNP	C	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:150869199C>A	uc004few.1	+	4	780	c.390C>A	c.(388-390)CCC>CCA	p.P130P		NM_024082	NP_076987	Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3	130	Cytoplasmic (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					ACACCCTCCCCCGGGTCATGG	0.657													8	25					0.000274275	0.00029555	0.004482	1	0
CNGA2	1260	broad.mit.edu	37	X	150912516	150912516	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:150912516C>T	uc004fey.1	+	7	1765	c.1541C>T	c.(1540-1542)TCG>TTG	p.S514L		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	514	cAMP (By similarity).|Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCTGCTGTCGGCTGGAAGC	0.438													10	40					0	0	0.010729	0	0
GABRE	2564	broad.mit.edu	37	X	151138708	151138708	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:151138708G>A	uc004ffi.2	-	2	277	c.223C>T	c.(223-225)CTG>TTG	p.L75L	GABRE_uc011myd.1_RNA|GABRE_uc011mye.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	75	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ATAGTGTTCAGGATGCGAGAG	0.537													19	48					0	0	0.014323	0	0
GABRQ	55879	broad.mit.edu	37	X	151821286	151821286	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:151821286G>A	uc004ffp.1	+	9	1461	c.1441G>A	c.(1441-1443)GAA>AAA	p.E481K		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	481						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TTTTCCTACCGAAATCCGCAA	0.547													8	49					0	0	0.003080	0	0
GABRQ	55879	broad.mit.edu	37	X	151821633	151821633	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:151821633C>T	uc004ffp.1	+	9	1808	c.1788C>T	c.(1786-1788)TTC>TTT	p.F596F		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	596						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGTTCTCCTTCGATCTCTTTA	0.527													7	16					0	0	0.001984	0	0
MAGEA12	4111	broad.mit.edu	37	X	151899949	151899949	+	Silent	SNP	C	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:151899949C>T	uc010ntp.2	-	3	1206	c.852G>A	c.(850-852)GTG>GTA	p.V284V	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Silent_p.V284V	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	284	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GCAGGACTTTCACATAGCTGG	0.542													15	87					0	0	0.004007	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900270	151900270	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:151900270G>A	uc010ntp.2	-	3	885	c.531C>T	c.(529-531)ATC>ATT	p.I177I	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Silent_p.I177I|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	177	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTGACAAGGATGTACAAGT	0.557													11	61					0	0	0.010729	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900452	151900453	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:151900452_151900453CC>TT	uc010ntp.2	-	3	702_703	c.348_349GG>AA	c.(346-351)TTGGTT>TTAATT	p.V117I	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.V117I|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	117	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					AGAAAATGAACCAACTCAGCCA	0.51													16	32					0	0	0.004672	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935336	151935336	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:151935336G>A	uc004fgp.2	-	3	1040	c.831C>T	c.(829-831)GCC>GCT	p.A277A		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	277	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCAACGAGGGCCCTTGGAC	0.527													32	48					0	0	0.012213	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935675	151935675	+	Silent	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:151935675G>A	uc004fgp.2	-	3	701	c.492C>T	c.(490-492)ATC>ATT	p.I164I		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	164	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					CCATCAGCTCGATGCCAAAGA	0.532													25	36					0	0	0.003954	0	0
PNMA5	114824	broad.mit.edu	37	X	152159167	152159167	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:152159167G>A	uc010ntw.2	-	3	1315	c.976C>T	c.(976-978)CGA>TGA	p.R326*	PNMA5_uc004fha.3_Nonsense_Mutation_p.R326*|PNMA5_uc010ntx.2_Nonsense_Mutation_p.R326*|PNMA5_uc004fgy.3_Nonsense_Mutation_p.R326*	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	326					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTCATCTCGAATGAGCTTC	0.567													15	21					0	0	0.002450	0	0
BGN	633	broad.mit.edu	37	X	152772344	152772344	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:152772344G>A	uc004fhr.1	+	6	905	c.733G>A	c.(733-735)GAA>AAA	p.E245K	BGN_uc004fhq.1_RNA	NM_001711	NP_001702	P21810	PGS1_HUMAN	biglycan preproprotein	245	LRR 8.					proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCAGGCCATCGAACTGGAGGA	0.602													13	37					0	0	0.003163	0	0
ATP2B3	492	broad.mit.edu	37	X	152818531	152818531	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:152818531G>A	uc004fht.1	+	11	1988	c.1862G>A	c.(1861-1863)GGC>GAC	p.G621D	ATP2B3_uc004fhs.1_Missense_Mutation_p.G621D	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	621	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GAACTCCGGGGCTTTCGGCCT	0.602													5	19					0	0	0.001984	0	0
HCFC1	3054	broad.mit.edu	37	X	153222120	153222120	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:153222120G>A	uc004fjp.2	-	15	3119	c.2591C>T	c.(2590-2592)GCC>GTC	p.A864V		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	864	Interaction with ZBTB17.|Interaction with GABP2.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGCTTGACGGCGGAGACGGT	0.632													12	19					0	0	0.013537	0	0
F8	2157	broad.mit.edu	37	X	154159223	154159223	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chrX:154159223G>A	uc004fmt.2	-	14	3013	c.2842C>T	c.(2842-2844)CTT>TTT	p.L948F		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	948	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GACTCAGTAAGGGGAGATGAC	0.388													3	31					0	0	0.009096	0	0
VPS13D	55187	broad.mit.edu	37	1	12405522	12405522	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:12405522delT	uc001atv.2	+	43	9118	c.8977delT	c.(8977-8979)TTTfs	p.F2993fs	VPS13D_uc001atw.2_Frame_Shift_Del_p.F2968fs|VPS13D_uc001atx.2_Frame_Shift_Del_p.F2180fs	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2992					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGTCGGGACCTTTTTTCGATA	0.483													7	129	---	---	---	---					
MAPKAPK2	9261	broad.mit.edu	37	1	206858676	206858678	+	In_Frame_Del	DEL	GCC	-	-			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:206858676_206858678delGCC	uc001hem.1	+	1	388_390	c.102_104delGCC	c.(100-105)CAGCCG>CAG	p.P40del	MAPKAPK2_uc001hel.1_In_Frame_Del_p.P40del	NM_032960	NP_116584	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated	40	Pro-rich.|Poly-Pro.				activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			ccccggcgcagccgccgccgccg	0.271													2	4	---	---	---	---					
DISP1	84976	broad.mit.edu	37	1	223178918	223178919	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr1:223178918_223178919insT	uc001hnu.1	+	8	4326_4327	c.4179_4180insT	c.(4177-4182)TCATTTfs	p.S1393fs		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1393_1394					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AGCCATCGTCATTTGTCTGCAG	0.455													19	279	---	---	---	---					
KIAA1826	84437	broad.mit.edu	37	11	105880579	105880579	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr11:105880579delG	uc001piy.2	-	3	894	c.721delC	c.(721-723)CGGfs	p.R241fs	KIAA1826_uc001piz.2_Frame_Shift_Del_p.R241fs	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	241	Potential.					nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		TCTAAATGCCGCAGCCTCTCT	0.463													16	64	---	---	---	---					
NEDD4L	23327	broad.mit.edu	37	18	56058729	56058729	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr18:56058729delT	uc002lgy.2	+	30	3037	c.2763delT	c.(2761-2763)GGTfs	p.G921fs	NEDD4L_uc002lgz.2_Frame_Shift_Del_p.G857fs|NEDD4L_uc002lgx.2_Frame_Shift_Del_p.G901fs|NEDD4L_uc010xee.1_Frame_Shift_Del_p.G800fs|NEDD4L_uc002lhc.2_Frame_Shift_Del_p.G913fs|NEDD4L_uc002lhd.2_Frame_Shift_Del_p.G800fs|NEDD4L_uc002lhb.2_Frame_Shift_Del_p.G780fs|NEDD4L_uc002lhe.2_Frame_Shift_Del_p.G893fs|NEDD4L_uc002lhf.2_Frame_Shift_Del_p.G780fs|NEDD4L_uc002lhg.2_Frame_Shift_Del_p.G800fs|NEDD4L_uc002lhh.2_Frame_Shift_Del_p.G696fs|NEDD4L_uc010dpn.2_Frame_Shift_Del_p.G124fs	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	921	HECT.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						GTTCCAATGGTCCTCAGCTGT	0.453													2	4	---	---	---	---					
GRLF1	2909	broad.mit.edu	37	19	47503883	47503884	+	Frame_Shift_Ins	INS	-	C	C			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr19:47503883_47503884insC	uc010ekv.2	+	6	4438_4439	c.4438_4439insC	c.(4438-4440)ACCfs	p.T1480fs		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1480	Pro-rich.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		GCCTCCACCCACCCCCCAGTCC	0.668													2	4	---	---	---	---					
MTA3	57504	broad.mit.edu	37	2	42871289	42871289	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr2:42871289delT	uc002rso.1	+	7	906	c.236delT	c.(235-237)GTCfs	p.V79fs	MTA3_uc002rsp.1_Frame_Shift_Del_p.V79fs|MTA3_uc002rsq.2_Frame_Shift_Del_p.V135fs|MTA3_uc002rsr.2_Frame_Shift_Del_p.V135fs	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	135	BAH.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TACTCATTGGTCTATGACCCC	0.353													8	41	---	---	---	---					
CDH10	1008	broad.mit.edu	37	5	24488051	24488051	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr5:24488051delA	uc003jgr.1	-	12	2420	c.2088delT	c.(2086-2088)TTTfs	p.F696fs	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	696	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCCGAGGAATAAATAACGTTT	0.502										HNSCC(23;0.051)			11	42	---	---	---	---					
RBM16	22828	broad.mit.edu	37	6	155153552	155153569	+	In_Frame_Del	DEL	CCACCCCAACGGGGAATC	-	-			TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr6:155153552_155153569delCCACCCCAACGGGGAATC	uc003qqa.2	+	21	3071_3088	c.2839_2856delCCACCCCAACGGGGAATC	c.(2839-2856)CCACCCCAACGGGGAATCdel	p.PPQRGI947del	TIAM2_uc003qqb.2_5'Flank|RBM16_uc011efj.1_In_Frame_Del_p.PPQRGI1013del|RBM16_uc011efk.1_In_Frame_Del_p.PPQRGI992del|RBM16_uc003qpz.2_In_Frame_Del_p.PPQRGI947del|RBM16_uc010kji.2_Intron	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	947_952	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		GCCTGGAATTCCACCCCAACGGGGAATCCCACCCCCAT	0.495													12	174	---	---	---	---					
C9orf150	286343	broad.mit.edu	37	9	12775861	12775862	+	In_Frame_Ins	INS	-	GGCGGCGGC	GGCGGCGGC	rs139315731	by1000genomes	TCGA-EE-A2MJ-06A-11D-A197-08	TCGA-EE-A2MJ-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	964d72a9-8897-4cf2-99a7-c7eddff542d5	649619f3-ace3-427f-b846-02c407a88a22	g.chr9:12775861_12775862insGGCGGCGGC	uc003zkw.2	+	1	850_851	c.147_148insGGCGGCGGC	c.(145-150)insGGCGGCGGC	p.55_56insGGG		NM_203403	NP_981948	Q8IV03	CI150_HUMAN	hypothetical protein LOC286343	58_59	Gly-rich.										0				GBM - Glioblastoma multiforme(1;1.64e-13)		gcggtggtggtggcggcggcgg	0.505													4	3	---	---	---	---					
