Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDK11B	984	broad.mit.edu	37	1	1575742	1575742	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:1575742G>A	uc001agv.1	-	15	1258	c.1147C>T	c.(1147-1149)CCG>TCG	p.P383S	CDK11B_uc009vkj.2_Missense_Mutation_p.P40S|CDK11B_uc001ags.1_Missense_Mutation_p.P241S|CDK11B_uc001agt.1_Missense_Mutation_p.P166S|CDK11B_uc001aha.1_Missense_Mutation_p.P349S|CDK11B_uc001agw.1_Missense_Mutation_p.P338S|CDK11B_uc001agy.1_Missense_Mutation_p.P381S|CDK11B_uc001agx.1_Missense_Mutation_p.P372S|CDK11B_uc001agz.1_Missense_Mutation_p.P127S	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	396					apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CTGCTCTGCGGCGTTCCCTCA	0.597													10	34					0	0	0.008291	0	0
NADK	65220	broad.mit.edu	37	1	1696731	1696731	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:1696731G>A	uc009vkw.2	-	2	236	c.115C>T	c.(115-117)CGG>TGG	p.R39W	NADK_uc001aic.2_Missense_Mutation_p.R39W|NADK_uc001aid.3_Missense_Mutation_p.R39W|NADK_uc001aie.2_Missense_Mutation_p.R39W|NADK_uc009vkx.1_5'UTR	NM_023018	NP_075394	O95544	NADK_HUMAN	NAD kinase	39					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		GCCCGGCCCCGGATGGGGTGG	0.577													27	66					0	0	0.006320	0	0
Unknown	0	broad.mit.edu	37	1	1854135	1854135	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:1854135C>T	uc001aik.2	-	10	1559	c.709G>A	c.(709-711)GCA>ACA	p.A237T	uc001ail.2_Missense_Mutation_p.A237T					RecName: Full=Uncharacterized protein C1orf222;																		TGCAGGGATGCGACGCTGTCT	0.632													19	59					0	0	0.001882	0	0
KIAA1751	85452	broad.mit.edu	37	1	1887200	1887200	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:1887200G>A	uc001aim.1	-	18	2262	c.2106C>T	c.(2104-2106)TCC>TCT	p.S702S	KIAA1751_uc009vkz.1_Silent_p.S702S	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	702										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		TGTCCGCCTGGGAGGACTCCG	0.607													22	75					0	0	0.002299	0	0
ACTRT2	140625	broad.mit.edu	37	1	2939042	2939042	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:2939042C>T	uc001ajz.2	+	1	997	c.792C>T	c.(790-792)TTC>TTT	p.F264F		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	264						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		AGGCCCTGTTCGTGCCCCAGC	0.642													19	68					0	0	0.001523	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3390083	3390083	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:3390083G>A	uc001akg.3	+	8	1550	c.1302G>A	c.(1300-1302)ATG>ATA	p.M434I	ARHGEF16_uc001aki.2_Missense_Mutation_p.M146I|ARHGEF16_uc001akj.2_Missense_Mutation_p.M146I|ARHGEF16_uc009vli.1_Missense_Mutation_p.M138I|ARHGEF16_uc010nzh.1_Missense_Mutation_p.M138I	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	434	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		CCCTCCTGATGGATGTAAGTC	0.672													15	67					0	0	0.004990	0	0
TAS1R1	80835	broad.mit.edu	37	1	6631072	6631072	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:6631072G>A	uc001ant.2	+	2	295	c.295G>A	c.(295-297)GGG>AGG	p.G99R	TAS1R1_uc001anu.2_Missense_Mutation_p.G99R|TAS1R1_uc001anv.2_Missense_Mutation_p.G99R|TAS1R1_uc001anw.2_Missense_Mutation_p.G99R	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	99	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CATCACCCTGGGGTACCAGCT	0.547													55	113					0	0	0.003610	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724259	7724259	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:7724259C>T	uc001aoi.2	+	9	1859	c.1652C>T	c.(1651-1653)TCC>TTC	p.S551F		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TACTCCTCCTCCGCGGCGGCT	0.667													11	38					0	0	0.001368	0	0
RERE	473	broad.mit.edu	37	1	8424199	8424199	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:8424199G>A	uc001ape.2	-	16	2467	c.1657C>T	c.(1657-1659)CCG>TCG	p.P553S	RERE_uc001apf.2_Missense_Mutation_p.P553S|RERE_uc010nzx.1_Missense_Mutation_p.P285S|RERE_uc001apd.2_5'UTR	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	553					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AACATAAACGGTGGCGGGTCC	0.607													24	60					0	0	0.002780	0	0
RERE	473	broad.mit.edu	37	1	8568705	8568705	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:8568705C>T	uc001ape.2	-	9	1670	c.860G>A	c.(859-861)CGT>CAT	p.R287H	RERE_uc001apf.2_Missense_Mutation_p.R287H|RERE_uc010nzx.1_Missense_Mutation_p.R19H|RERE_uc001aph.1_Missense_Mutation_p.R287H	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	287	ELM2.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AGGACCGACACGAATCTCCCC	0.403													14	57					0	0	0.003163	0	0
KIF1B	23095	broad.mit.edu	37	1	10412779	10412779	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:10412779C>T	uc001aqx.3	+	38	4242	c.4040C>T	c.(4039-4041)TCC>TTC	p.S1347F	KIF1B_uc001aqw.3_Missense_Mutation_p.S1301F|KIF1B_uc001aqy.2_Missense_Mutation_p.S1321F|KIF1B_uc001aqz.2_Missense_Mutation_p.S1347F|KIF1B_uc001ara.2_Missense_Mutation_p.S1307F|KIF1B_uc001arb.2_Missense_Mutation_p.S1333F	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	1347					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CTGAAGTCTTCCCACAACTCT	0.458													26	77					0	0	0.004656	0	0
PGD	5226	broad.mit.edu	37	1	10464303	10464303	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:10464303C>T	uc001arc.2	+	5	506	c.416C>T	c.(415-417)CCA>CTA	p.P139L	PGD_uc001ard.2_Missense_Mutation_p.H58Y|PGD_uc010oak.1_Missense_Mutation_p.P117L|PGD_uc010oal.1_Missense_Mutation_p.P126L	NM_002631	NP_002622	P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	139					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		CGGTATGGCCCATCGCTCATG	0.552													14	49					0	0	0.004990	0	0
EXOSC10	5394	broad.mit.edu	37	1	11141286	11141286	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:11141286G>A	uc001asa.2	-	11	1340	c.1290C>T	c.(1288-1290)CCC>CCT	p.P430P	EXOSC10_uc001asb.2_Silent_p.P430P|EXOSC10_uc009vmy.1_Silent_p.P430P	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	430					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		GCATCTCCTCGGGCAGAGGGC	0.532													29	72					0	0	0.002096	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561714	11561714	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:11561714G>A	uc001ash.3	+	2	803	c.665G>A	c.(664-666)CGA>CAA	p.R222Q	PTCHD2_uc001asi.1_Missense_Mutation_p.R222Q	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	222	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GAAGACCCGCGAAACCAGCGG	0.692													5	19					0	0	0.001168	0	0
PLOD1	5351	broad.mit.edu	37	1	12017929	12017929	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:12017929C>T	uc001atm.2	+	8	863	c.772C>T	c.(772-774)CCG>TCG	p.P258S	PLOD1_uc010obb.1_Missense_Mutation_p.P305S	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	258					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	CAACTACATCCCGCGCTTCTG	0.627													16	77					0	0	0.001882	0	0
TNFRSF8	943	broad.mit.edu	37	1	12175783	12175783	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:12175783C>T	uc001atq.2	+	8	1165	c.943C>T	c.(943-945)CAG>TAG	p.Q315*	TNFRSF8_uc010obc.1_Nonsense_Mutation_p.Q204*	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	315	Extracellular (Potential).|TNFR-Cys 6.				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		CACCAAGCCCCAGGGTAAGCA	0.622													9	17					0	0	0.008291	0	0
AADACL3	126767	broad.mit.edu	37	1	12785820	12785820	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:12785820G>A	uc009vnn.1	+	4	1143	c.910G>A	c.(910-912)GAA>AAA	p.E304K	AADACL3_uc001aug.1_Missense_Mutation_p.E234K	NM_001103170	NP_001096640	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3 isoform 1	304							hydrolase activity				0	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GAAAAGGCTGGAAGACCTGGG	0.517													21	62					0	0	0.001523	0	0
C1orf158	93190	broad.mit.edu	37	1	12819250	12819250	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:12819250C>T	uc001auh.2	+	3	449	c.233C>T	c.(232-234)CCT>CTT	p.P78L	C1orf158_uc010obe.1_Missense_Mutation_p.P78L	NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	78										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGGGCTACCTTACAAACAC	0.577													47	132					0	0	0.003610	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12837394	12837394	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:12837394C>T	uc001aui.2	+	3	1131	c.1104C>T	c.(1102-1104)ATC>ATT	p.I368I		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	368	LRR 2.									ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAGCGCCATCCTGCCTGCCC	0.632													23	61					0	0	0.003954	0	0
SPEN	23013	broad.mit.edu	37	1	16262683	16262683	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:16262683C>T	uc001axk.1	+	11	10152	c.9948C>T	c.(9946-9948)CCC>CCT	p.P3316P	SPEN_uc010obp.1_Silent_p.P3275P	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3316	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCTACCACCCCCCGGCCCAGC	0.632													13	42					0	0	0.003163	0	0
EPHA2	1969	broad.mit.edu	37	1	16458768	16458768	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:16458768C>T	uc001aya.1	-	13	2253	c.2116G>A	c.(2116-2118)GAG>AAG	p.E706K		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	706	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.|Cytoplasmic (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CCATCCTTCTCCTGCCGGAGC	0.657													18	23					0	0	0.007413	0	0
FBXO42	54455	broad.mit.edu	37	1	16577532	16577532	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:16577532C>T	uc001ayg.2	-	10	2003	c.1787G>A	c.(1786-1788)GGA>GAA	p.G596E	FBXO42_uc001aye.3_Missense_Mutation_p.G314E|FBXO42_uc001ayf.2_Missense_Mutation_p.G503E	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	596										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		CACTGTTTCTCCACTGCTCAA	0.607													27	53					0	0	0.004656	0	0
NBPF1	55672	broad.mit.edu	37	1	16892241	16892241	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:16892241C>A	uc009vos.1	-	28	4064	c.3176G>T	c.(3175-3177)AGA>ATA	p.R1059I	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1059	NBPF 7.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGAATAACATCTATCCAGTGA	0.468													23	633					1.7367e-05	2.63369e-05	0.006320	1	0
NBPF1	55672	broad.mit.edu	37	1	16902764	16902764	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:16902764G>A	uc009vos.1	-	19	3005	c.2117C>T	c.(2116-2118)CCA>CTA	p.P706L	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Missense_Mutation_p.P164L|NBPF1_uc010oce.1_Missense_Mutation_p.P435L	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	706						cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CACCTTACCTGGGCTGAGCTT	0.537													14	353					0	0	0.001523	0	0
MST1P9	11223	broad.mit.edu	37	1	17085527	17085527	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:17085527G>A	uc010ock.1	-	10	1164	c.1164C>T	c.(1162-1164)GCC>GCT	p.A388A	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						CCAGGGTTAGGGCCCTGGCGG	0.652													5	44					0	0	0.000978	0	0
PADI4	23569	broad.mit.edu	37	1	17657546	17657546	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:17657546A>C	uc001baj.2	+	2	203	c.175A>C	c.(175-177)AAG>CAG	p.K59Q	PADI4_uc009vpc.2_Missense_Mutation_p.K59Q	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	59					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CCCTCCAGCCAAGAAGAAATC	0.602													18	36					0	0	0.007413	0	0
UBR4	23352	broad.mit.edu	37	1	19403252	19403252	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:19403252C>T	uc001bbi.2	-	105	15473	c.15469G>A	c.(15469-15471)GAG>AAG	p.E5157K	UBR4_uc001bbe.1_5'Flank|UBR4_uc001bbf.2_Missense_Mutation_p.E52K|UBR4_uc010ocv.1_Missense_Mutation_p.E680K|UBR4_uc009vph.2_Missense_Mutation_p.E812K|UBR4_uc010ocw.1_Missense_Mutation_p.E821K|UBR4_uc001bbg.2_Missense_Mutation_p.E868K|UBR4_uc001bbh.2_Missense_Mutation_p.E866K	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	5157					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCGAGGAACTCTGAGAAGGTC	0.527													73	148					0	0	0.003610	0	0
UBR4	23352	broad.mit.edu	37	1	19454738	19454739	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:19454738_19454739GG>AA	uc001bbi.2	-	62	9081_9082	c.9077_9078CC>TT	c.(9076-9078)TCC>TTT	p.S3026F	UBR4_uc001bbk.1_Missense_Mutation_p.S673F	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3026					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CAATAAGCTGGGAGAGCAGGTT	0.446													43	103					0	0	0.004672	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21928215	21928215	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:21928215G>A	uc001bex.2	-	20	1872	c.1614C>T	c.(1612-1614)TCC>TCT	p.S538S	RAP1GAP_uc001bev.2_Silent_p.S623S|RAP1GAP_uc001bew.2_Silent_p.S602S|RAP1GAP_uc001bey.2_Silent_p.S564S	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	538					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		AGCTCTGAGTGGATGAGTTCT	0.672													18	28					0	0	0.002299	0	0
HSPG2	3339	broad.mit.edu	37	1	22173091	22173091	+	Silent	SNP	G	A	A	rs141870522		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:22173091G>A	uc001bfj.2	-	63	8206	c.8166C>T	c.(8164-8166)GCC>GCT	p.A2722A	HSPG2_uc009vqd.2_Silent_p.A2723A	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2722	Ig-like C2-type 12.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGCTGCCAGGGGCTGGGGGAA	0.597													18	42					0	0	0.002299	0	0
TCEB3	6924	broad.mit.edu	37	1	24080647	24080647	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:24080647C>T	uc001bho.2	+	6	1733	c.1673C>T	c.(1672-1674)TCC>TTC	p.S558F		NM_003198	NP_003189	Q14241	ELOA1_HUMAN	elongin A	558	Activation domain (By similarity).				positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		AGAATGAATTCCAAGATGCAG	0.448													24	60					0	0	0.003954	0	0
IL28RA	163702	broad.mit.edu	37	1	24484157	24484157	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:24484157G>A	uc001bis.2	-	7	1039	c.1026C>T	c.(1024-1026)CCC>CCT	p.P342P	IL28RA_uc001bir.2_Silent_p.P313P|IL28RA_uc001bit.2_3'UTR|IL28RA_uc001biu.2_Silent_p.P258P	NM_170743	NP_734464	Q8IU57	I28RA_HUMAN	interleukin 28 receptor, alpha isoform 1	342	Cytoplasmic (Potential).				cytokine-mediated signaling pathway|negative regulation of cell proliferation|regulation of defense response to virus by host	interleukin-28 receptor complex	protein binding|receptor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00117)|all_lung(284;0.00151)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.21e-24)|Colorectal(126;6.61e-08)|COAD - Colon adenocarcinoma(152;3.56e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00918)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.185)		GTTCAATGTAGGGCTGGAAGC	0.617													32	59					0	0	0.001786	0	0
TMEM57	55219	broad.mit.edu	37	1	25812149	25812149	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:25812149C>T	uc001bkk.2	+	8	1561	c.1359C>T	c.(1357-1359)ATC>ATT	p.I453I	TMEM57_uc009vru.2_Silent_p.I226I|TMEM57_uc009vrv.2_Silent_p.I95I	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	453						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		AGCAGAATATCAGCCAGTTGG	0.353													39	64					0	0	0.007835	0	0
ARID1A	8289	broad.mit.edu	37	1	27087520	27087520	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:27087520C>T	uc001bmv.1	+	5	2467	c.2094C>T	c.(2092-2094)TCC>TCT	p.S698S	ARID1A_uc001bmt.1_Silent_p.S698S|ARID1A_uc001bmu.1_Silent_p.S698S|ARID1A_uc001bmw.1_Silent_p.S315S	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	698					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTTCCCCGTCCCCTGTTGGCT	0.607			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								21	41					0	0	0.002299	0	0
ARID1A	8289	broad.mit.edu	37	1	27088718	27088718	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:27088718C>T	uc001bmv.1	+	7	2700	c.2327C>T	c.(2326-2328)CCT>CTT	p.P776L	ARID1A_uc001bmt.1_Missense_Mutation_p.P776L|ARID1A_uc001bmu.1_Missense_Mutation_p.P776L|ARID1A_uc001bmw.1_Missense_Mutation_p.P393L	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	776				P -> L (in Ref. 1; AAG33967, 5; AAG17549 and 7; BAA23269).	androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCGCGTCAGCCTTCCGGAGGA	0.572			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								28	66					0	0	0.005443	0	0
ARID1A	8289	broad.mit.edu	37	1	27100165	27100165	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:27100165C>T	uc001bmv.1	+	16	4334	c.3961C>T	c.(3961-3963)CCT>TCT	p.P1321S	ARID1A_uc001bmt.1_Missense_Mutation_p.P1320S|ARID1A_uc001bmu.1_Missense_Mutation_p.P1321S|ARID1A_uc001bmw.1_Missense_Mutation_p.P938S|ARID1A_uc001bmx.1_Missense_Mutation_p.P167S|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1321					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GATGTATTCTCCTAGCCGCTA	0.527			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								22	43					0	0	0.002780	0	0
C1orf172	126695	broad.mit.edu	37	1	27278866	27278866	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:27278866G>A	uc001bni.1	-	2	95	c.6C>T	c.(4-6)CCC>CCT	p.P2P		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	2	Pro-rich.									large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GTCCAGGGCGGGGCATGGCTC	0.617													22	65					0	0	0.004656	0	0
GMEB1	10691	broad.mit.edu	37	1	29041250	29041250	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:29041250G>A	uc001bra.2	+	10	1825	c.1687G>A	c.(1687-1689)GTT>ATT	p.V563I	GMEB1_uc001bqz.2_Missense_Mutation_p.V553I|GMEB1_uc001brb.2_Missense_Mutation_p.V553I	NM_006582	NP_006573	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding	563					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGCATCAAGTTCACAATGT	0.423													25	42					0	0	0.005443	0	0
TINAGL1	64129	broad.mit.edu	37	1	32048836	32048836	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:32048836A>G	uc001bta.2	+	4	587	c.461A>G	c.(460-462)AAC>AGC	p.N154S	TINAGL1_uc001bsz.2_Missense_Mutation_p.N9S|TINAGL1_uc010ogj.1_Intron|TINAGL1_uc010ogk.1_Missense_Mutation_p.N154S	NM_022164	NP_071447	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	154					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		AACCAGGGCAACTATGGGTGA	0.567													18	35					0	0	0.007413	0	0
COL16A1	1307	broad.mit.edu	37	1	32133812	32133812	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:32133812G>A	uc001btk.1	-	51	3622	c.3257C>T	c.(3256-3258)CCA>CTA	p.P1086L	COL16A1_uc001bti.1_5'UTR|COL16A1_uc001btj.1_Missense_Mutation_p.P884L	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	1086	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TGGTTGCCCTGGAGGACCCTG	0.602													17	38					0	0	0.002299	0	0
BAI2	576	broad.mit.edu	37	1	32204489	32204490	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:32204489_32204490GG>AA	uc001btn.2	-	16	2898_2899	c.2544_2545CC>TT	c.(2542-2547)CCCCCT>CCTTCT	p.P849S	BAI2_uc001btp.1_5'Flank|BAI2_uc010ogn.1_5'Flank|BAI2_uc010ogo.1_Missense_Mutation_p.P491S|BAI2_uc010ogp.1_Missense_Mutation_p.P782S|BAI2_uc010ogq.1_Missense_Mutation_p.P849S|BAI2_uc001bto.2_Missense_Mutation_p.P849S|BAI2_uc001btq.1_Missense_Mutation_p.P782S	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	849	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GGCTGGGTAGGGGGGCGCACAG	0.634													22	112					0	0	0.004672	0	0
SPOCD1	90853	broad.mit.edu	37	1	32279600	32279600	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:32279600G>A	uc001bts.1	-	2	1393	c.1335C>T	c.(1333-1335)TCC>TCT	p.S445S	SPOCD1_uc001btu.2_Silent_p.S445S|SPOCD1_uc001btv.2_Intron	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	445					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TGTCCTGGTGGGAGTTGTCTG	0.572													26	75					0	0	0.006320	0	0
KIAA1522	57648	broad.mit.edu	37	1	33236519	33236519	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:33236519C>T	uc001bvv.2	+	6	1698	c.1562C>T	c.(1561-1563)CCC>CTC	p.P521L	KIAA1522_uc001bvu.1_Missense_Mutation_p.P580L|KIAA1522_uc010ohm.1_Missense_Mutation_p.P532L|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	521	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				ACACTTTCGCCCTCCAGTGGA	0.667													5	9					0	0	0.000602	0	0
CSMD2	114784	broad.mit.edu	37	1	34192243	34192243	+	Silent	SNP	G	A	A	rs140431671		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:34192243G>A	uc001bxn.1	-	16	2321	c.2292C>T	c.(2290-2292)CTC>CTT	p.L764L	CSMD2_uc001bxm.1_Silent_p.L804L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	764	CUB 5.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGCCCGGAGAGAGGATGGTGC	0.577													14	39					0	0	0.002450	0	0
C1orf94	84970	broad.mit.edu	37	1	34677988	34677988	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:34677988C>T	uc001bxs.3	+	6	1531	c.1132C>T	c.(1132-1134)CTC>TTC	p.L378F	C1orf94_uc001bxt.2_Missense_Mutation_p.L568F	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	378							protein binding				0		Myeloproliferative disorder(586;0.0393)				ACCGCAGTACCTCTTTCCCCA	0.577													9	16					0	0	0.004482	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370480	35370481	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:35370480_35370481GG>AA	uc001byc.2	-	1	504_505	c.504_505CC>TT	c.(502-507)AGCCGC>AGTTGC	p.R169C		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	169					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				TGCCGGATGCGGCTAGGGCTCT	0.668													11	32					0	0	0.004672	0	0
TEKT2	27285	broad.mit.edu	37	1	36553171	36553171	+	Silent	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:36553171C>A	uc001bzr.2	+	8	1114	c.987C>A	c.(985-987)CTC>CTA	p.L329L	TEKT2_uc001bzs.2_Silent_p.L235L|ADPRHL2_uc001bzt.2_5'Flank|ADPRHL2_uc001bzu.2_5'Flank	NM_014466	NP_055281	Q9UIF3	TEKT2_HUMAN	tektin 2	329	Potential.			L -> F (in Ref. 1; AAC09343).	cell projection organization|microtubule cytoskeleton organization	actin cytoskeleton|cilium axoneme|flagellar axoneme|focal adhesion|microtubule|nucleolus					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				ACGTGGAACTCTGCCGGGACC	0.617													9	19					6.40141e-05	9.69018e-05	0.000978	1	0
GRIK3	2899	broad.mit.edu	37	1	37285408	37285408	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:37285408G>A	uc001caz.2	-	12	1937	c.1802C>T	c.(1801-1803)TCC>TTC	p.S601F	GRIK3_uc001cba.1_Missense_Mutation_p.S601F	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	601	Cytoplasmic (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CACCACCTCGGAGCCAGGGTT	0.577													7	12					0	0	0.003080	0	0
RSPO1	284654	broad.mit.edu	37	1	38078451	38078451	+	Silent	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:38078451T>C	uc001cbl.1	-	8	1556	c.768A>G	c.(766-768)CCA>CCG	p.P256P	RSPO1_uc001cbm.1_Silent_p.P256P|RSPO1_uc009vvf.1_Silent_p.P229P|RSPO1_uc009vvg.1_Silent_p.P193P	NM_001038633	NP_001033722	Q2MKA7	RSPO1_HUMAN	R-spondin1 precursor	256					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CAGATGTGAGTGGCCCCACTG	0.602													32	99					0	0	0.002096	0	0
EPHA10	284656	broad.mit.edu	37	1	38184057	38184057	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:38184057C>T	uc009vvi.2	-	17	3100	c.3014G>A	c.(3013-3015)GGG>GAG	p.G1005E	EPHA10_uc001cbt.2_RNA|EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	1005	Cytoplasmic (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CACCTGCACCCCCTGGCCCTG	0.662													18	72					0	0	0.008871	0	0
RHBDL2	54933	broad.mit.edu	37	1	39381234	39381234	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:39381234C>T	uc001ccu.1	-	3	623	c.395G>A	c.(394-396)GGA>GAA	p.G132E	RHBDL2_uc010oin.1_Missense_Mutation_p.G132E|RHBDL2_uc010oio.1_Missense_Mutation_p.G212E|RHBDL2_uc001ccv.2_Missense_Mutation_p.G132E	NM_017821	NP_060291	Q9NX52	RHBL2_HUMAN	rhomboid protease 2	132	Helical; (Potential).				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity				0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CATTGCTTACCCAGCATGTAC	0.343													20	61					0	0	0.001523	0	0
MACF1	23499	broad.mit.edu	37	1	39782178	39782178	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:39782178G>A	uc010ois.1	+	29	3785	c.3580G>A	c.(3580-3582)GAG>AAG	p.E1194K	MACF1_uc001cda.1_Missense_Mutation_p.E1102K|MACF1_uc001cdc.1_Missense_Mutation_p.E281K|MACF1_uc009vvq.1_Missense_Mutation_p.E251K|MACF1_uc001cdb.1_Missense_Mutation_p.E281K	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1194	LRR 7.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTCAGCTCTGGAGGCCCATTG	0.433													47	79					0	0	0.003610	0	0
MACF1	23499	broad.mit.edu	37	1	39800079	39800079	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:39800079G>A	uc010oiu.1	+	1	3270	c.3139G>A	c.(3139-3141)GAA>AAA	p.E1047K	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2612	Plectin 10.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTTAACTAATGAAGCAGTATT	0.408													26	42					0	0	0.003330	0	0
HPCAL4	51440	broad.mit.edu	37	1	40148263	40148263	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:40148263G>A	uc001cdr.2	-	4	641	c.521C>T	c.(520-522)GCA>GTA	p.A174V	HPCAL4_uc010oix.1_Missense_Mutation_p.A102V	NM_016257	NP_057341	Q9UM19	HPCL4_HUMAN	hippocalcin-like protein 4	174	EF-hand 4.				central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			ACTCTTGGCTGCCTCCTTGAA	0.567													21	70					0	0	0.004656	0	0
OXCT2	64064	broad.mit.edu	37	1	40236126	40236126	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:40236126G>A	uc001ceb.1	-	1	895	c.802C>T	c.(802-804)CGC>TGC	p.R268C	BMP8B_uc001cdz.1_Intron|BMP8B_uc001cea.1_Intron|OXCT2_uc009vvu.1_Missense_Mutation_p.R262C	NM_022120	NP_071403	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2 precursor	268					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			pancreas(1)	1	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	TTTATCACGCGATCTACATAA	0.537											OREG0013400	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	70					0	0	0.002836	0	0
ZMPSTE24	10269	broad.mit.edu	37	1	40756656	40756656	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:40756656C>T	uc001cfg.2	+	9	1401	c.1190C>T	c.(1189-1191)TCA>TTA	p.S397L		NM_005857	NP_005848	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	397	Helical; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity				0	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			TTTATTTTTTCACCTTACAAT	0.343													22	69					0	0	0.002780	0	0
ZNF643	65243	broad.mit.edu	37	1	40928260	40928260	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:40928260C>T	uc001cfn.1	+	5	901	c.604C>T	c.(604-606)CAA>TAA	p.Q202*	ZNF643_uc001cfl.1_Nonsense_Mutation_p.Q100*|ZNF643_uc001cfm.1_Nonsense_Mutation_p.Q68*	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			ACAAGAGAACCAAAGAATGGG	0.398													52	118					0	0	0.003610	0	0
WDR65	149465	broad.mit.edu	37	1	43649261	43649261	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:43649261G>A	uc001cip.1	+	4	596	c.475_splice	c.e4-1	p.V159_splice	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Splice_Site_p.V148_splice|WDR65_uc001ciq.1_Splice_Site_p.V159_splice	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65											skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACATTTTACAGGTGAGCTTCA	0.373													22	34					0	0	0.002780	0	0
MED8	112950	broad.mit.edu	37	1	43850172	43850172	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:43850172C>T	uc001cje.1	-	8	903	c.855G>A	c.(853-855)AAG>AAA	p.K285K		NM_052877	NP_443109	Q96G25	MED8_HUMAN	mediator complex subunit 8 isoform 3	Error:Variant_position_missing_in_Q96G25_after_alignment					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCAGAAGCTTCTTCACCTTGC	0.517													6	21					0	0	0.003080	0	0
KIAA0467	23334	broad.mit.edu	37	1	43891737	43891737	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:43891737C>T	uc001cjk.1	+	7	894	c.432C>T	c.(430-432)GTC>GTT	p.V144V	KIAA0467_uc009vws.1_Silent_p.V986V	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	986						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACACCTGCGTCCATGAGATCC	0.557													10	35					0	0	0.000978	0	0
KIAA0467	23334	broad.mit.edu	37	1	43895512	43895512	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:43895512C>T	uc001cjk.1	+	14	2070	c.1608C>T	c.(1606-1608)ATC>ATT	p.I536I		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1435						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ATAGCGTCATCCAGGTGGGAA	0.597													32	57					0	0	0.002096	0	0
KLF17	128209	broad.mit.edu	37	1	44595349	44595349	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:44595349G>A	uc001clp.2	+	2	464	c.406G>A	c.(406-408)GGA>AGA	p.G136R	KLF17_uc009vxf.1_Missense_Mutation_p.G99R	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	136					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					AATGCCCGTAGGAGAGCCCAA	0.542													22	50					0	0	0.002299	0	0
RNF220	55182	broad.mit.edu	37	1	44878025	44878025	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:44878025C>T	uc001clv.1	+	2	616	c.256C>T	c.(256-258)CGT>TGT	p.R86C	RNF220_uc001clw.1_Missense_Mutation_p.R86C	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	86					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TTTTGCCAATCGTGATTTCCC	0.507													76	189					0	0	0.003610	0	0
PLK3	1263	broad.mit.edu	37	1	45271237	45271237	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:45271237C>T	uc001cmn.2	+	15	1928	c.1828C>T	c.(1828-1830)CGT>TGT	p.R610C	PLK3_uc001cmo.2_RNA|BTBD19_uc010old.1_5'Flank|BTBD19_uc010ole.1_5'Flank	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	610	POLO box 2.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					GGCCCGAAATCGTAGTGCTTG	0.602													45	80					0	0	0.008740	0	0
HECTD3	79654	broad.mit.edu	37	1	45476265	45476265	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:45476265G>A	uc009vxk.2	-	2	581	c.483C>T	c.(481-483)CTC>CTT	p.L161L	HECTD3_uc001cmy.3_5'Flank|HECTD3_uc010olh.1_Intron|UROD_uc010oli.1_5'Flank|UROD_uc001cna.1_5'Flank|UROD_uc001cnb.1_5'Flank|UROD_uc010olj.1_5'Flank|UROD_uc001cnc.1_5'Flank	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	161					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					GCTGCCGCTGGAGGTGGTTGG	0.692													9	24					0	0	0.004482	0	0
PRDX1	5052	broad.mit.edu	37	1	45980275	45980275	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:45980275G>A	uc001cnz.2	-	4	450	c.418C>T	c.(418-420)CGG>TGG	p.R140W	PRDX1_uc001coa.2_Missense_Mutation_p.R140W|PRDX1_uc001cob.2_Missense_Mutation_p.R140W|PRDX1_uc001coc.2_Missense_Mutation_p.R140W	NM_181697	NP_859048	Q06830	PRDX1_HUMAN	peroxiredoxin 1	140	Thioredoxin.				cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity				0	Acute lymphoblastic leukemia(166;0.155)					GTGATCTGCCGAAGAATACCC	0.443													43	102					0	0	0.003610	0	0
CYP4X1	260293	broad.mit.edu	37	1	47515123	47515123	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:47515123G>A	uc001cqt.2	+	11	1552	c.1302G>A	c.(1300-1302)GAG>GAA	p.E434E	CYP4X1_uc001cqr.2_Silent_p.E433E|CYP4X1_uc001cqs.2_Silent_p.E369E	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	434						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						TCTCTCAGGAGAATTCTGATC	0.443													26	88					0	0	0.006320	0	0
SLC5A9	200010	broad.mit.edu	37	1	48697266	48697266	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:48697266G>A	uc001cro.2	+	6	712	c.660G>A	c.(658-660)ATG>ATA	p.M220I	SLC5A9_uc010oms.1_RNA|SLC5A9_uc001crn.2_Missense_Mutation_p.M245I|SLC5A9_uc010omt.1_Missense_Mutation_p.M234I|SLC5A9_uc001crp.2_5'UTR|SLC5A9_uc010omu.1_5'UTR	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	220	Helical; (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						CGGTGATCATGGTAGGGGGAG	0.542													5	35					0	0	0.000602	0	0
DMRTA2	63950	broad.mit.edu	37	1	50884876	50884876	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:50884876G>A	uc010ona.1	-	2	1186	c.1090C>T	c.(1090-1092)CCT>TCT	p.P364S	DMRTA2_uc010onb.1_Missense_Mutation_p.P364S	NM_032110	NP_115486	Q96SC8	DMTA2_HUMAN	DMRT-like family A2	364	Ala-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						GGCGCCGCAGGGCCCAGGCCG	0.642													3	2					0	0	0.004672	0	0
LRP8	7804	broad.mit.edu	37	1	53729861	53729861	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:53729861G>A	uc001cvi.1	-	10	1777	c.1635C>T	c.(1633-1635)ATC>ATT	p.I545I	LRP8_uc001cvh.1_Silent_p.I98I|LRP8_uc001cvk.1_Silent_p.I375I|LRP8_uc001cvj.1_Silent_p.I545I|LRP8_uc001cvl.1_Silent_p.I416I|LRP8_uc001cvm.1_Silent_p.I130I	NM_004631	NP_004622	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein	545	LDL-receptor class B 2.|Extracellular (Potential).				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0						GGTCAACAGCGATGGCCCGGG	0.572													16	15					0	0	0.003163	0	0
C1orf175	374977	broad.mit.edu	37	1	55136553	55136554	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:55136553_55136554CC>TT	uc010ooe.1	+	7	1874_1875	c.1550_1551CC>TT	c.(1549-1551)TCC>TTT	p.S517F	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.S85F|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.S35F|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.S517F|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	517						integral to membrane	binding				0						TCCCTGCCCTCCGTGCAGGCGA	0.653													8	6					0	0	0.004672	0	0
C1orf175	374977	broad.mit.edu	37	1	55139793	55139793	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:55139793C>T	uc010ooe.1	+	10	2229	c.1905C>T	c.(1903-1905)ATC>ATT	p.I635I	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Silent_p.I203I|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Silent_p.I153I|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Silent_p.I635I|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	635						integral to membrane	binding				0						ACGGCATCATCATCCTCTACA	0.512													26	55					0	0	0.006320	0	0
TTC4	7268	broad.mit.edu	37	1	55197279	55197279	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:55197279C>T	uc001cxx.3	+	7	855	c.802C>T	c.(802-804)CTA>TTA	p.L268L	C1orf175_uc001cxq.2_Intron|TTC4_uc001cxw.3_Intron|TTC4_uc001cxv.2_Silent_p.L279L	NM_004623	NP_004614	O95801	TTC4_HUMAN	tetratricopeptide repeat domain 4	268							binding				0						CAGGCTGAGTCTAGATGGCCA	0.547													14	17					0	0	0.002450	0	0
C8A	731	broad.mit.edu	37	1	57349320	57349320	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:57349320C>T	uc001cyo.2	+	6	953	c.821C>T	c.(820-822)TCA>TTA	p.S274L		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	274	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						CAAGACACTTCATTCTTGAAC	0.403													9	18					0	0	0.000978	0	0
L1TD1	54596	broad.mit.edu	37	1	62675692	62675692	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:62675692G>A	uc001dae.3	+	4	1548	c.1246G>A	c.(1246-1248)GAA>AAA	p.E416K		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	416	Glu-rich.									ovary(1)|skin(1)	2						gctggaggaggaagaagaaga	0.259													13	9					0	0	0.001368	0	0
DOCK7	85440	broad.mit.edu	37	1	62993884	62993884	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:62993884C>G	uc001daq.2	-	31	3908	c.3874G>C	c.(3874-3876)GCA>CCA	p.A1292P	DOCK7_uc001dan.2_Missense_Mutation_p.A1153P|DOCK7_uc001dao.2_Missense_Mutation_p.A1153P|DOCK7_uc001dap.2_Missense_Mutation_p.A1261P|DOCK7_uc001dam.2_Missense_Mutation_p.A472P|DOCK7_uc010oov.1_Intron	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1292					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CCTGCGATTGCCATGGCAACG	0.433													17	30					0	0	0.004990	0	0
TCTEX1D1	200132	broad.mit.edu	37	1	67220397	67220397	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:67220397G>A	uc001dcv.2	+	2	187	c.56G>A	c.(55-57)GGG>GAG	p.G19E	TCTEX1D1_uc009wau.2_RNA|TCTEX1D1_uc009wav.2_RNA	NM_152665	NP_689878	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	19											0						AAGAAAAGAGGGAGTATTTCT	0.353													14	10					0	0	0.003163	0	0
TCTEX1D1	200132	broad.mit.edu	37	1	67236143	67236143	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:67236143G>A	uc001dcv.2	+	3	324	c.193G>A	c.(193-195)GAA>AAA	p.E65K	TCTEX1D1_uc009wau.2_RNA|TCTEX1D1_uc009wav.2_RNA	NM_152665	NP_689878	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	65											0						AGTTCAGATGGAAAACACCTA	0.353													53	73					0	0	0.003610	0	0
RPE65	6121	broad.mit.edu	37	1	68912499	68912499	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:68912499G>A	uc001dei.1	-	3	193	c.139C>T	c.(139-141)CCA>TCA	p.P47S		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	47					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						AAGAGTCCTGGCCCACATCGA	0.517													28	35					0	0	0.002096	0	0
LRRC7	57554	broad.mit.edu	37	1	70460305	70460305	+	Silent	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:70460305T>C	uc001dep.2	+	9	909	c.879T>C	c.(877-879)AAT>AAC	p.N293N	LRRC7_uc009wbg.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	293	LRR 12.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TGCTACCCAATACAATTGGAA	0.328													37	77					0	0	0.006999	0	0
NEGR1	257194	broad.mit.edu	37	1	71873147	71873147	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:71873147C>A	uc001dfw.2	-	7	1147	c.1047G>T	c.(1045-1047)AAG>AAT	p.K349N	NEGR1_uc001dfv.2_Missense_Mutation_p.K221N|NEGR1_uc010oqs.1_Missense_Mutation_p.K305N	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	349					cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GAATGGCATTCTTCAGGTAGA	0.428													12	17					5.50884e-06	8.36546e-06	0.001368	1	0
NEGR1	257194	broad.mit.edu	37	1	72241872	72241872	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:72241872C>T	uc001dfw.2	-	3	618	c.518G>A	c.(517-519)CGA>CAA	p.R173Q	NEGR1_uc001dfv.2_Missense_Mutation_p.R45Q|NEGR1_uc010oqs.1_Missense_Mutation_p.R173Q	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	173	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GGAGATGTGTCGCCAAGAAAT	0.418													16	11					0	0	0.004990	0	0
C1orf173	127254	broad.mit.edu	37	1	75036964	75036964	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:75036964C>T	uc001dgg.2	-	14	4649	c.4430G>A	c.(4429-4431)GGA>GAA	p.G1477E		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1477	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCGTGATAATCCTAATCGGAA	0.552													39	46					0	0	0.006999	0	0
GBP2	2634	broad.mit.edu	37	1	89582871	89582871	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:89582871G>A	uc001dmz.1	-	6	943	c.672C>T	c.(670-672)ATC>ATT	p.I224I	GBP2_uc001dmy.1_RNA	NM_004120	NP_004111	P32456	GBP2_HUMAN	guanylate binding protein 2,	224					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)	1		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		AGAACTTTCGGATGCACAACC	0.403													16	26					0	0	0.007413	0	0
GBP5	115362	broad.mit.edu	37	1	89730416	89730416	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:89730416T>A	uc001dnc.2	-	8	1639	c.1102A>T	c.(1102-1104)AAA>TAA	p.K368*	GBP5_uc001dnd.2_Nonsense_Mutation_p.K368*|GBP5_uc001dne.1_Nonsense_Mutation_p.K368*	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	368						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		AAAGAGTTTTTCATGAAGACT	0.463													32	30					0	0	0.002836	0	0
LRRC8D	55144	broad.mit.edu	37	1	90398924	90398924	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:90398924C>T	uc001dnm.2	+	3	722	c.297C>T	c.(295-297)TCC>TCT	p.S99S	LRRC8D_uc001dnn.2_Silent_p.S99S	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	99						integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		ACGACATTTCCTTTGGGACAT	0.498													13	12					0	0	0.001368	0	0
TGFBR3	7049	broad.mit.edu	37	1	92195499	92195499	+	Silent	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:92195499C>A	uc001doh.2	-	6	1066	c.600G>T	c.(598-600)GGG>GGT	p.G200G	TGFBR3_uc009wde.2_5'UTR|TGFBR3_uc010osy.1_Silent_p.G158G|TGFBR3_uc001doi.2_Silent_p.G200G|TGFBR3_uc001doj.2_Silent_p.G200G	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	200	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		GAAAATTCTTCCCTATGTTGC	0.478													28	69					9.65021e-13	1.47076e-12	0.002096	1	0
ALG14	199857	broad.mit.edu	37	1	95538372	95538372	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:95538372G>A	uc001dra.2	-	1	136	c.83C>T	c.(82-84)TCC>TTC	p.S28F		NM_144988	NP_659425	Q96F25	ALG14_HUMAN	asparagine-linked glycosylation 14 homolog	28	Cytoplasmic (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity				0		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.0615)|Epithelial(280;0.139)		AACGTCCATGGAACGAAGCAC	0.562													27	28					0	0	0.007291	0	0
PTBP2	58155	broad.mit.edu	37	1	97217021	97217021	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:97217021G>T	uc001drq.2	+	3	326	c.80G>T	c.(79-81)AGT>ATT	p.S27I	PTBP2_uc001drn.2_Missense_Mutation_p.S27I|PTBP2_uc001dro.2_Missense_Mutation_p.S27I|PTBP2_uc010otz.1_Missense_Mutation_p.S38I|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Intron|PTBP2_uc001drr.2_Missense_Mutation_p.S27I|PTBP2_uc010oua.1_Missense_Mutation_p.S35I|PTBP2_uc001dru.2_RNA|PTBP2_uc001drm.2_Missense_Mutation_p.S27I	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	27							nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		GTTCTCAGTAGTCCGAACTCT	0.348													65	80					1.17597e-53	1.80373e-53	0.003610	1	0
DPYD	1806	broad.mit.edu	37	1	97981388	97981388	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:97981388G>A	uc001drv.2	-	13	1771	c.1634C>T	c.(1633-1635)CCT>CTT	p.P545L		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	545					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AAGACCAAAAGGATTTATAAA	0.458													24	24					0	0	0.003954	0	0
LPPR4	9890	broad.mit.edu	37	1	99771774	99771774	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:99771774G>A	uc001dse.2	+	7	1606	c.1500G>A	c.(1498-1500)CAG>CAA	p.Q500Q	LPPR4_uc010oue.1_Silent_p.Q442Q	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	500							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CTGGCAATCAGTACCTCAAAA	0.572													58	90					0	0	0.003610	0	0
COL11A1	1301	broad.mit.edu	37	1	103347311	103347311	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:103347311G>A	uc001dul.2	-	65	5300	c.4982C>T	c.(4981-4983)TCA>TTA	p.S1661L	COL11A1_uc001duk.2_Missense_Mutation_p.S857L|COL11A1_uc001dum.2_Missense_Mutation_p.S1673L|COL11A1_uc001dun.2_Missense_Mutation_p.S1622L|COL11A1_uc009weh.2_Missense_Mutation_p.S1545L	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1661	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGGCCATGATGAAATTCTTAC	0.318													4	14					0	0	0.001168	0	0
FNDC7	163479	broad.mit.edu	37	1	109270433	109270433	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:109270433C>T	uc001dvx.2	+	7	1115	c.1115C>T	c.(1114-1116)CCC>CTC	p.P372L	FNDC7_uc010ova.1_Missense_Mutation_p.P139L	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	373						extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		CTTTCAGCTCCCTGTTGTCCT	0.552													30	86					0	0	0.002445	0	0
WDR47	22911	broad.mit.edu	37	1	109525357	109525357	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:109525357A>G	uc001dwj.2	-	12	2516	c.2140T>C	c.(2140-2142)TTG>CTG	p.L714L	WDR47_uc001dwl.2_Silent_p.L722L|WDR47_uc001dwi.2_Silent_p.L715L|WDR47_uc010ovf.1_Silent_p.L639L	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	714	WD 3.									ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		ATAAATGCCAAGTCTCTAATT	0.388													167	428					0	0	0.003610	0	0
GPR61	83873	broad.mit.edu	37	1	110085662	110085663	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:110085662_110085663CC>TT	uc001dxy.2	+	2	701_702	c.18_19CC>TT	c.(16-21)ATCCCC>ATTTCC	p.P7S		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	7	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity	p.P7S(1)		central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCTCACCCATCCCCCAGTCATC	0.649													11	15					0	0	0.004672	0	0
KCNA10	3744	broad.mit.edu	37	1	111060402	111060402	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:111060402G>A	uc001dzt.1	-	1	1396	c.1008C>T	c.(1006-1008)TCC>TCT	p.S336S		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	336						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GGATGGCCAGGGACATGTTCT	0.542													37	85					0	0	0.002852	0	0
SYT6	148281	broad.mit.edu	37	1	114636410	114636410	+	Nonstop_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:114636410A>C	uc001eev.2	-	7	1526	c.1276T>G	c.(1276-1278)TGA>GGA	p.*426G	SYT6_uc001eeu.2_Intron	NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	426	Cytoplasmic (Potential).|C2 2.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAATGAAATCACAACCGAGGG	0.453													33	79					0	0	0.003271	0	0
VANGL1	81839	broad.mit.edu	37	1	116206695	116206695	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:116206695C>T	uc001efv.1	+	4	889	c.618C>T	c.(616-618)GTC>GTT	p.V206V	VANGL1_uc009wgy.1_Silent_p.V204V|VANGL1_uc001efw.1_Silent_p.V206V	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	vang-like 1	206	Extracellular (Potential).				multicellular organismal development	integral to membrane	protein binding			central_nervous_system(1)	1	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTTACGGGGTCCGCATTTTGG	0.517													50	111					0	0	0.003610	0	0
IGSF3	3321	broad.mit.edu	37	1	117122046	117122046	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:117122046G>A	uc001egr.1	-	10	4007	c.3302C>T	c.(3301-3303)TCA>TTA	p.S1101L	IGSF3_uc001egq.1_Missense_Mutation_p.S1121L	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	1101	Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GATGGGGGCTGACTCCTCCTC	0.537													29	59					0	0	0.002096	0	0
CD101	9398	broad.mit.edu	37	1	117568166	117568166	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:117568166G>A	uc010oxb.1	+	8	2522	c.2464G>A	c.(2464-2466)GAA>AAA	p.E822K	CD101_uc009whd.2_Missense_Mutation_p.E822K|CD101_uc010oxc.1_Missense_Mutation_p.E822K|CD101_uc010oxd.1_Missense_Mutation_p.E760K	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	822	Ig-like C2-type 7.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GTACTGGACCGAAAATGTGAC	0.463													28	54					0	0	0.004289	0	0
SPAG17	200162	broad.mit.edu	37	1	118514651	118514651	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:118514651C>T	uc001ehk.2	-	45	6229	c.6161G>A	c.(6160-6162)GGA>GAA	p.G2054E		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	2054						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GTTCACTTTTCCTCCAACAGA	0.373													15	37					0	0	0.004007	0	0
SPAG17	200162	broad.mit.edu	37	1	118567984	118567984	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:118567984G>A	uc001ehk.2	-	27	3854	c.3786C>T	c.(3784-3786)TAC>TAT	p.Y1262Y		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1262						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CCCTCTGGGGGTAGCTCTGAC	0.473													32	80					0	0	0.006230	0	0
TBX15	6913	broad.mit.edu	37	1	119428089	119428089	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:119428089G>A	uc001ehl.1	-	8	1072	c.757C>T	c.(757-759)CCT>TCT	p.P253S	TBX15_uc009whj.1_Missense_Mutation_p.P77S	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	359						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GAAGCCGAAGGGGATGGTGTC	0.488													6	18					0	0	0.003080	0	0
HSD3B2	3284	broad.mit.edu	37	1	119964532	119964532	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:119964532C>T	uc001ehs.2	+	3	1181	c.408C>T	c.(406-408)ATC>ATT	p.I136I	HSD3B2_uc001eht.2_Silent_p.I136I|HSD3B2_uc001ehu.2_Intron	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	136					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	ACAAGGAAATCATCCAGAACG	0.542													35	89					0	0	0.002836	0	0
ADAM30	11085	broad.mit.edu	37	1	120436799	120436799	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:120436799C>T	uc001eij.2	-	1	2315	c.2161G>A	c.(2161-2163)GAA>AAA	p.E721K		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	721	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GGCATTTTTTCCTGTTTGGGT	0.353													202	487					0	0	0.003610	0	0
ADAM30	11085	broad.mit.edu	37	1	120437893	120437893	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:120437893C>T	uc001eij.2	-	1	1221	c.1067G>A	c.(1066-1068)AGG>AAG	p.R356K		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	356	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		AAGCCTACCCCTACATTGGCA	0.433													207	535					0	0	0.003610	0	0
PPIAL4G	644591	broad.mit.edu	37	1	143767584	143767584	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:143767584T>G	uc001ejt.2	-	1	298	c.265A>C	c.(265-267)ATC>CTC	p.I89L		NM_001123068	NP_001116540	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like	89	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity				0						TGCTTTCGGATGAGGTTCTCA	0.468													22	85					0	0	0.002780	0	0
LIX1L	128077	broad.mit.edu	37	1	145492310	145492310	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:145492310C>T	uc001enr.2	+	3	606	c.532C>T	c.(532-534)CCT>TCT	p.P178S	NBPF10_uc001emp.3_Intron	NM_153713	NP_714924	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse) like	178										ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TAATGAACATCCTTCCCGAAG	0.478													37	73					0	0	0.004878	0	0
GJA5	2702	broad.mit.edu	37	1	147230828	147230828	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:147230828G>A	uc001eps.1	-	2	660	c.519C>T	c.(517-519)TTC>TTT	p.F173F	GJA5_uc001ept.1_Silent_p.F173F	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	173	Helical; (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			TTCCGTAGATGAAGTACTGGC	0.567													16	28					0	0	0.003163	0	0
LOC200030	200030	broad.mit.edu	37	1	148344720	148344720	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:148344720G>A	uc001eqf.2	-	2	233	c.198C>T	c.(196-198)CTC>CTT	p.L66L	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqg.2_Intron|NBPF14_uc009wkf.1_Intron|uc001erd.3_Silent_p.L66L|uc001erc.3_Intron|uc010paj.1_Intron|uc010pau.1_5'Flank|uc010pav.1_Silent_p.L66L|uc010paw.1_Intron	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	66						cytoplasm					0						TAAATTTTATGAGGTCTTTAC	0.537													12	252					0	0	0.006122	0	0
LOC645166	645166	broad.mit.edu	37	1	148932815	148932815	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:148932815C>T	uc010pbc.1	+	2		c.130C>T			LOC645166_uc010pbd.1_RNA|LOC645166_uc009wkw.1_RNA	NR_027355				Homo sapiens cDNA, FLJ18771.												0						AGCTAGCCCGCCAGGCCTCCA	0.597													13	144					0	0	0.001855	0	0
MTMR11	10903	broad.mit.edu	37	1	149906993	149906993	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:149906993G>A	uc001etl.3	-	5	605	c.354C>T	c.(352-354)CTC>CTT	p.L118L	MTMR11_uc001etm.1_Silent_p.L46L|MTMR11_uc010pbm.1_Silent_p.L90L|MTMR11_uc010pbn.1_5'UTR	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	118							phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			ACCCTGGACGGAGGAGCTGGA	0.547													21	42					0	0	0.003330	0	0
RPRD2	23248	broad.mit.edu	37	1	150445429	150445429	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:150445429C>T	uc009wlr.2	+	11	4206	c.4005C>T	c.(4003-4005)ACC>ACT	p.T1335T	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Silent_p.T1309T	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1335	Pro-rich.						protein binding			ovary(1)	1						TTCAAGGGACCCTGGCTGAGC	0.637													18	8					0	0	0.008871	0	0
GOLPH3L	55204	broad.mit.edu	37	1	150621114	150621114	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:150621114G>A	uc001evj.2	-	5	758	c.541C>T	c.(541-543)CTG>TTG	p.L181L	GOLPH3L_uc010pci.1_Silent_p.L137L	NM_018178	NP_060648	Q9H4A5	GLP3L_HUMAN	Golgi phosphoprotein 3-like	181						Golgi cisterna membrane				ovary(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TCAAATAGCAGGAAATTCTGC	0.418													50	17					0	0	0.003610	0	0
GABPB2	126626	broad.mit.edu	37	1	151070367	151070367	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:151070367G>A	uc001ewr.2	+	5	842	c.511G>A	c.(511-513)GCC>ACC	p.A171T	GABPB2_uc010pcp.1_Missense_Mutation_p.A187T|GABPB2_uc001ews.2_Missense_Mutation_p.A131T|GABPB2_uc001ewt.2_Missense_Mutation_p.A70T	NM_144618	NP_653219	Q8TAK5	GABP2_HUMAN	GA repeat binding protein, beta 2	171					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein heterodimerization activity|transcription regulatory region DNA binding				0				all cancers(107;7.17e-05)|GBM - Glioblastoma multiforme(94;0.000662)		TCCAGAGAGAGCCAACCCTGT	0.408													29	42					0	0	0.002096	0	0
ZNF687	57592	broad.mit.edu	37	1	151262009	151262009	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:151262009A>G	uc001exq.2	+	5	2725	c.2627A>G	c.(2626-2628)CAT>CGT	p.H876R	ZNF687_uc009wmo.2_Missense_Mutation_p.H876R|ZNF687_uc009wmp.2_Missense_Mutation_p.H876R	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	876	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ATGCTGGAACATCTCAAGGTA	0.557													19	89					0	0	0.001882	0	0
HRNR	388697	broad.mit.edu	37	1	152188255	152188255	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:152188255G>A	uc001ezt.1	-	3	5926	c.5850C>T	c.(5848-5850)AGC>AGT	p.S1950S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1950	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCGGCCACGGCTAGGGCTAG	0.607													99	393					0	0	0.003610	0	0
FLG2	388698	broad.mit.edu	37	1	152324716	152324716	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:152324716C>T	uc001ezw.3	-	3	5619	c.5546G>A	c.(5545-5547)GGA>GAA	p.G1849E	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1849							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGTCTGTCCATGAGTAGT	0.502													56	175					0	0	0.003610	0	0
FLG2	388698	broad.mit.edu	37	1	152324872	152324872	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:152324872C>T	uc001ezw.3	-	3	5463	c.5390G>A	c.(5389-5391)GGA>GAA	p.G1797E	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1797	Filaggrin 7.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACCTTCTTCCAGTGGTCCT	0.547													53	181					0	0	0.003610	0	0
CRNN	49860	broad.mit.edu	37	1	152382122	152382122	+	Missense_Mutation	SNP	C	T	T	rs138795800		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:152382122C>T	uc001ezx.2	-	3	1510	c.1436G>A	c.(1435-1437)CGA>CAA	p.R479Q		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	479					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGATGCCTCGCTTCTCTTC	0.542													16	68					0	0	0.004007	0	0
SPRR2G	6706	broad.mit.edu	37	1	153122541	153122541	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:153122541G>A	uc009wod.1	-	2	167	c.46C>T	c.(46-48)CCT>TCT	p.P16S		NM_001014291	NP_001014313	Q9BYE4	SPR2G_HUMAN	small proline-rich protein 2G	16					keratinization	cornified envelope|cytoplasm					0	all_lung(78;1.78e-30)|Lung NSC(65;7.29e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGCACACAGGAGGTGGCTGG	0.572													33	105					0	0	0.004878	0	0
INTS3	65123	broad.mit.edu	37	1	153721217	153721217	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:153721217C>T	uc009wom.2	+	7	791	c.570C>T	c.(568-570)ATC>ATT	p.I190I	INTS3_uc001fct.2_Silent_p.I190I|INTS3_uc001fcu.2_5'UTR|INTS3_uc001fcv.2_5'UTR|INTS3_uc010peb.1_5'Flank|INTS3_uc001fcw.2_5'Flank	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	191					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TTCTGGATATCCTGACAGAGC	0.468													82	240					0	0	0.003610	0	0
DENND4B	9909	broad.mit.edu	37	1	153906615	153906615	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:153906615G>A	uc001fdd.1	-	19	3338	c.2937C>T	c.(2935-2937)GCC>GCT	p.A979A	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	979										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			ACTCACTGTGGGCCACACCGG	0.637													3	12					0	0	0.004672	0	0
CRTC2	200186	broad.mit.edu	37	1	153923985	153923985	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:153923985G>A	uc010ped.1	-	11	1225	c.1155C>T	c.(1153-1155)ACC>ACT	p.T385T	CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Intron	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	385	Ser-rich.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGCCCAGGGAGGTGGTGGGCA	0.567													13	38					0	0	0.004990	0	0
NUP210L	91181	broad.mit.edu	37	1	154018578	154018578	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:154018578C>T	uc001fdw.2	-	27	3735	c.3663G>A	c.(3661-3663)AGG>AGA	p.R1221R	NUP210L_uc009woq.2_Silent_p.R130R|NUP210L_uc010peh.1_Silent_p.R1221R	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1221						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CCAATACATCCCTTTTGCTCA	0.398													26	32					0	0	0.008361	0	0
NUP210L	91181	broad.mit.edu	37	1	154072525	154072525	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:154072525A>C	uc001fdw.2	-	14	1986	c.1914T>G	c.(1912-1914)TGT>TGG	p.C638W	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.C638W	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	638						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AGTACTTGTCACATTCATTCA	0.403													56	184					0	0	0.003610	0	0
IL6R	3570	broad.mit.edu	37	1	154403046	154403047	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:154403046_154403047CC>TT	uc001fez.1	+	3	859_860	c.422_423CC>TT	c.(421-423)TCC>TTT	p.S141F	IL6R_uc001ffa.1_Missense_Mutation_p.S141F	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	141	Extracellular (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGCACCCCATCCCTGACGACAA	0.594													29	17					0	0	0.004672	0	0
ADAR	103	broad.mit.edu	37	1	154574527	154574527	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:154574527G>A	uc001ffh.2	-	2	791	c.591C>T	c.(589-591)ATC>ATT	p.I197I	ADAR_uc001ffj.2_Silent_p.I197I|ADAR_uc001ffi.2_Silent_p.I197I|ADAR_uc001ffk.2_5'UTR|ADAR_uc001ffl.1_5'UTR	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	197	DRADA 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TGGAGACCGCGATTTTCCACA	0.522													60	144					0	0	0.003610	0	0
RAG1AP1	55974	broad.mit.edu	37	1	155108417	155108417	+	Silent	SNP	C	G	G	rs141021704		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155108417C>G	uc001fhj.3	+	1	130	c.30C>G	c.(28-30)CTC>CTG	p.L10L	RAG1AP1_uc010pey.1_RNA|RAG1AP1_uc001fhk.3_5'UTR|RAG1AP1_uc001fhl.3_Silent_p.L10L	NM_018845	NP_061333	Q9BRV3	SWET1_HUMAN	recombination activating gene 1 activating	10	MtN3/slv 1.|Helical; Name=1; (Potential).				positive regulation of gene expression, epigenetic	Golgi membrane|integral to membrane|plasma membrane	glucoside transmembrane transporter activity				0	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGACTCGCTCATTTACGGAG	0.662													10	22					0	0	0.001368	0	0
THBS3	7059	broad.mit.edu	37	1	155174669	155174669	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155174669C>T	uc001fix.2	-	4	646	c.623G>A	c.(622-624)GGG>GAG	p.G208E	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Missense_Mutation_p.G208E|THBS3_uc001fiz.2_Missense_Mutation_p.G208E|THBS3_uc001fiy.2_Intron|THBS3_uc010pfu.1_Intron|THBS3_uc010pfv.1_Intron|THBS3_uc001fja.2_RNA|THBS3_uc009wqj.1_Missense_Mutation_p.G170E	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	208					cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGACTCGTCCCCTTGGAATGG	0.537													48	161					0	0	0.003610	0	0
PKLR	5313	broad.mit.edu	37	1	155264450	155264450	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155264450C>T	uc001fkb.3	-	6	827	c.788G>A	c.(787-789)GGG>GAG	p.G263E	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Missense_Mutation_p.G232E	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	263			G -> R (in PKRD).|G -> W (in PKRD).		endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	CTCGGACAGCCCGGGCAAGTC	0.677													22	9					0	0	0.002299	0	0
ASH1L	55870	broad.mit.edu	37	1	155450033	155450034	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155450033_155450034GG>AA	uc009wqq.2	-	3	3107_3108	c.2627_2628CC>TT	c.(2626-2628)TCC>TTT	p.S876F	ASH1L_uc001fkt.2_Missense_Mutation_p.S876F|ASH1L_uc009wqr.1_Missense_Mutation_p.S876F	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	876					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CTTGTTTGAAGGAAGGGATTTC	0.421													139	53					0	0	0.004672	0	0
GON4L	54856	broad.mit.edu	37	1	155796811	155796811	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155796811G>C	uc001flz.2	-	3	611	c.514C>G	c.(514-516)CAA>GAA	p.Q172E	GON4L_uc001fly.1_Missense_Mutation_p.Q172E|GON4L_uc009wrh.1_Missense_Mutation_p.Q172E|GON4L_uc001fma.1_Missense_Mutation_p.Q172E|GON4L_uc001fmc.2_Missense_Mutation_p.Q172E|GON4L_uc001fmd.3_Missense_Mutation_p.Q172E|GON4L_uc009wri.2_5'UTR|GON4L_uc001fme.2_5'UTR	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	172					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GAATTCATTTGAGGTTTCCCT	0.428													12	69					0	0	0.002450	0	0
SEMA4A	64218	broad.mit.edu	37	1	156127865	156127865	+	Missense_Mutation	SNP	C	T	T	rs143382589		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:156127865C>T	uc001fnl.2	+	4	409	c.305C>T	c.(304-306)CCG>CTG	p.P102L	SEMA4A_uc009wrq.2_Missense_Mutation_p.P102L|SEMA4A_uc001fnm.2_Missense_Mutation_p.P102L|SEMA4A_uc001fnn.2_Missense_Mutation_p.P3L|SEMA4A_uc001fno.2_Missense_Mutation_p.P102L	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	102	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					TTTCAGATACCGTGGCCAGCC	0.498													11	43					0	0	0.000978	0	0
CRABP2	1382	broad.mit.edu	37	1	156670740	156670740	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:156670740C>G	uc001fpr.2	-	2	312	c.175G>C	c.(175-177)GTG>CTG	p.V59L		NM_001878	NP_001869	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	59					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity			upper_aerodigestive_tract(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)	GTGGTGCGCACGGTGGTGGAG	0.547													13	57					0	0	0.002450	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156911701	156911701	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:156911701G>A	uc001fqo.2	-	33	4327	c.3287C>T	c.(3286-3288)CCC>CTC	p.P1096L	ARHGEF11_uc010phu.1_Missense_Mutation_p.P512L|ARHGEF11_uc001fqn.2_Missense_Mutation_p.P1136L	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1096	Poly-Pro.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	p.I1096L(1)		ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGGACCTGGGGGTGGAGGATG	0.647													21	54					0	0	0.003330	0	0
FCRL3	115352	broad.mit.edu	37	1	157665914	157665914	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:157665914C>T	uc001frb.2	-	7	1340	c.1048G>A	c.(1048-1050)GAG>AAG	p.E350K	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.E350K|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Missense_Mutation_p.E76K|FCRL3_uc001frc.1_Missense_Mutation_p.E350K	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	350	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					GCATCACTCTCCTTCACGGTG	0.517													63	25					0	0	0.003610	0	0
FCRL1	115350	broad.mit.edu	37	1	157772381	157772381	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:157772381G>A	uc001frg.2	-	4	506	c.393C>T	c.(391-393)GTC>GTT	p.V131V	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Silent_p.V131V|FCRL1_uc001fri.2_Silent_p.V131V|FCRL1_uc001frj.2_Intron	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	131	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGCAGATGAGGACCAGCCTGT	0.537													41	12					0	0	0.008740	0	0
OR10K2	391107	broad.mit.edu	37	1	158390485	158390485	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:158390485G>A	uc010pii.1	-	1	172	c.172C>T	c.(172-174)CCC>TCC	p.P58S		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AAGTACATGGGGATATGAAGG	0.493													65	97					0	0	0.003610	0	0
OR6K3	391114	broad.mit.edu	37	1	158686981	158686981	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:158686981C>T	uc010pip.1	-	1	973	c.973G>A	c.(973-975)GTG>ATG	p.V325M		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	325	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					TTGTTCAACACTTTTTGAAGA	0.308													24	121					0	0	0.007291	0	0
OR6K3	391114	broad.mit.edu	37	1	158687328	158687328	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:158687328G>A	uc010pip.1	-	1	626	c.626C>T	c.(625-627)TCC>TTC	p.S209F		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	209	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CAGAATCATGGACGTGTCTGT	0.453													45	133					0	0	0.003610	0	0
CADM3	57863	broad.mit.edu	37	1	159166195	159166195	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159166195C>T	uc001ftl.2	+	6	875	c.733C>T	c.(733-735)CGT>TGT	p.R245C	CADM3_uc009wsy.1_Missense_Mutation_p.R199C|CADM3_uc001ftk.2_Missense_Mutation_p.R279C	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	245	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					TCCCCATCCTCGTGAGGGCCA	0.517											OREG0013913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	11					0	0	0.003271	0	0
FCER1A	2205	broad.mit.edu	37	1	159273800	159273800	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159273800G>A	uc001ftq.2	+	4	258	c.159G>A	c.(157-159)GGG>GGA	p.G53G		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	53	Extracellular (Potential).|Ig-like 1.					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CATGTAATGGGAACAATTTCT	0.368													21	65					0	0	0.002299	0	0
OR10J3	441911	broad.mit.edu	37	1	159283829	159283829	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159283829G>A	uc010piu.1	-	1	621	c.621C>T	c.(619-621)GTC>GTT	p.V207V		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					GTAGAACAAGGACACAGACGC	0.478													22	104					0	0	0.002299	0	0
OR10J1	26476	broad.mit.edu	37	1	159409836	159409836	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159409836C>T	uc010piv.1	+	1	288	c.288C>T	c.(286-288)CTC>CTT	p.L96L	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	96	Extracellular (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					TCTCCAGCCTCGTAGGTATGA	0.468													50	27					0	0	0.003610	0	0
CCDC19	25790	broad.mit.edu	37	1	159860371	159860371	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159860371G>A	uc001fui.2	-	3	189	c.171C>T	c.(169-171)CTC>CTT	p.L57L	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_5'UTR|CCDC19_uc001ful.2_5'UTR|CCDC19_uc009wtc.1_Silent_p.L57L	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	57						mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			GCTTATCTCGGAGCAGCACAA	0.542													39	122					0	0	0.002522	0	0
IGSF9	57549	broad.mit.edu	37	1	159904006	159904007	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159904006_159904007CC>TT	uc001fur.2	-	9	1275_1276	c.1077_1078GG>AA	c.(1075-1080)AAGGAT>AAAAAT	p.D360N	IGSF9_uc001fuq.2_Missense_Mutation_p.D344N|IGSF9_uc001fup.2_5'Flank	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	360	Ig-like 4.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GCCTTTCCATCCTTGGTCCAGC	0.614													22	10					0	0	0.004672	0	0
SLAMF9	89886	broad.mit.edu	37	1	159921548	159921548	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159921548C>T	uc001fus.2	-	4	890	c.773G>A	c.(772-774)CGA>CAA	p.R258Q	SLAMF9_uc009wtd.2_Missense_Mutation_p.R167Q|SLAMF9_uc001fut.2_3'UTR	NM_033438	NP_254273	Q96A28	SLAF9_HUMAN	SLAM family member 9 isoform 1	258	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TTTCTGGACTCGGATGACCCA	0.498													51	68					0	0	0.003610	0	0
ATP1A2	477	broad.mit.edu	37	1	160105224	160105224	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:160105224G>A	uc001fvc.2	+	16	2248	c.2116G>A	c.(2116-2118)GGA>AGA	p.G706R	ATP1A2_uc001fvb.2_Missense_Mutation_p.G706R|ATP1A2_uc001fvd.2_Missense_Mutation_p.G442R	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	706	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TTCCCTCCAGGGAGCCATTGT	0.617													9	58					0	0	0.008291	0	0
ATP1A4	480	broad.mit.edu	37	1	160128877	160128877	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:160128877G>A	uc001fve.3	+	5	1090	c.611G>A	c.(610-612)GGA>GAA	p.G204E	ATP1A4_uc001fvf.3_RNA	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	204	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATCAAGGGTGGAGACCGAGTC	0.512													22	108					0	0	0.001882	0	0
ATP1A4	480	broad.mit.edu	37	1	160151744	160151744	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:160151744C>T	uc001fve.3	+	20	3371	c.2892C>T	c.(2890-2892)ATC>ATT	p.I964I	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Silent_p.I467I|ATP1A4_uc001fvh.2_Silent_p.I100I	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	964	Helical; (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TATTTGGGATCCTGGAGGAGA	0.522													51	188					0	0	0.003610	0	0
CD84	8832	broad.mit.edu	37	1	160523164	160523164	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:160523164C>T	uc001fwh.3	-	4	788	c.764G>A	c.(763-765)AGG>AAG	p.R255K	CD84_uc001fwf.3_Intron|CD84_uc001fwg.3_Intron|CD84_uc009wtn.2_Intron|CD84_uc001fwi.3_Intron|CD84_uc001fwj.2_Missense_Mutation_p.R255K	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	255	Cytoplasmic (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TGGGAAAATCCTACCTTGTCT	0.463													15	50					0	0	0.003163	0	0
ITLN1	55600	broad.mit.edu	37	1	160850994	160850994	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:160850994C>T	uc001fxc.2	-	5	630	c.514G>A	c.(514-516)GAC>AAC	p.D172N		NM_017625	NP_060095	Q8WWA0	ITLN1_HUMAN	intelectin precursor	172	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)	7	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AAGCCAGTGTCCGTGCGGTAC	0.562													84	45					0	0	0.003610	0	0
LMX1A	4009	broad.mit.edu	37	1	165175183	165175183	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:165175183G>A	uc001gcy.1	-	7	1127	c.906C>T	c.(904-906)ATC>ATT	p.I302I	LMX1A_uc001gcz.1_Silent_p.I302I|LMX1A_uc001gcw.1_Silent_p.I20I|LMX1A_uc001gcx.1_Silent_p.I53I	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	302						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CACTCTGCTCGATGGCCAGGA	0.577													23	86					0	0	0.002299	0	0
ILDR2	387597	broad.mit.edu	37	1	166896407	166896407	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:166896407A>G	uc001gdx.1	-	7	947	c.891T>C	c.(889-891)GGT>GGC	p.G297G		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	297	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						GGATCCGGTAACCTTTGCGAA	0.453													95	41					0	0	0.003610	0	0
ADCY10	55811	broad.mit.edu	37	1	167805628	167805628	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:167805628C>T	uc001ger.2	-	23	3526	c.3228G>A	c.(3226-3228)CTG>CTA	p.L1076L	ADCY10_uc009wvj.2_5'Flank|ADCY10_uc009wvk.2_Silent_p.L984L|ADCY10_uc010plj.1_Silent_p.L923L	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1076					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						CTCCCAAAGCCAGAAAATGGT	0.398													24	60					0	0	0.002780	0	0
GPR161	23432	broad.mit.edu	37	1	168066078	168066078	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:168066078A>T	uc001gfc.2	-	5	1081	c.767T>A	c.(766-768)TTT>TAT	p.F256Y	GPR161_uc001gfb.2_Missense_Mutation_p.F124Y|GPR161_uc010pll.1_Missense_Mutation_p.F166Y|GPR161_uc010plm.1_Missense_Mutation_p.F142Y|GPR161_uc009wvo.2_Missense_Mutation_p.F273Y|GPR161_uc001gfd.2_Missense_Mutation_p.F256Y|GPR161_uc010pln.1_Missense_Mutation_p.F276Y|GPR161_uc001gfe.1_Missense_Mutation_p.F256Y	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	256	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					CACACCCTGAAAGGCATTCCT	0.597													48	153					0	0	0.003610	0	0
F5	2153	broad.mit.edu	37	1	169484697	169484697	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:169484697G>A	uc001ggg.1	-	24	6658	c.6513C>T	c.(6511-6513)TCC>TCT	p.S2171S		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	2171	F5/8 type C 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCACCATGGAGGATTTCAGCC	0.438													210	114					0	0	0.003610	0	0
SELE	6401	broad.mit.edu	37	1	169697262	169697262	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:169697262C>T	uc001ggm.3	-	8	1373	c.1216G>A	c.(1216-1218)GGA>AGA	p.G406R	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	406	Sushi 4.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					CTTTTGGATCCCTTCAACACA	0.473													40	147					0	0	0.007835	0	0
DNM3	26052	broad.mit.edu	37	1	172356454	172356454	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:172356454C>T	uc001gie.2	+	19	2416	c.2240C>T	c.(2239-2241)CCG>CTG	p.P747L	DNM3_uc001gif.2_Missense_Mutation_p.P743L|DNM3_uc001gih.1_Missense_Mutation_p.P103L	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	753					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						GTGTCCACTCCGGCACCCCCT	0.463													13	33					0	0	0.001855	0	0
C1orf9	51430	broad.mit.edu	37	1	172578958	172578958	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:172578958G>C	uc001giq.3	+	24	3640	c.3324G>C	c.(3322-3324)AAG>AAC	p.K1108N	C1orf9_uc009wwd.2_Missense_Mutation_p.K1064N|C1orf9_uc010pmn.1_Missense_Mutation_p.K737N|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	1108					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		TGTTGTAGAAGAAGCGCTGCA	0.398													12	39					0	0	0.001855	0	0
TNN	63923	broad.mit.edu	37	1	175046794	175046794	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:175046794G>A	uc001gkl.1	+	2	353	c.240G>A	c.(238-240)GAG>GAA	p.E80E	TNN_uc010pmx.1_Silent_p.E80E	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	80					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGGCCAGGGAGGAACAGAACA	0.607													34	15					0	0	0.006999	0	0
TNN	63923	broad.mit.edu	37	1	175049410	175049410	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:175049410G>A	uc001gkl.1	+	4	1009	c.896G>A	c.(895-897)GGG>GAG	p.G299E	TNN_uc010pmx.1_Missense_Mutation_p.G299E	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	299	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TACCCCCTGGGGAAGGAGCTC	0.577													16	74					0	0	0.006122	0	0
ASTN1	460	broad.mit.edu	37	1	177001815	177001815	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:177001815C>T	uc001glc.2	-	3	854	c.642G>A	c.(640-642)CGG>CGA	p.R214R	ASTN1_uc001glb.1_Silent_p.R214R|ASTN1_uc001gld.1_Silent_p.R214R|ASTN1_uc009wwx.1_Silent_p.R214R|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	214					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GCAGGCTCTCCCGTCCGTGCC	0.622													36	14					0	0	0.005524	0	0
LHX4	89884	broad.mit.edu	37	1	180240974	180240974	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:180240974G>A	uc001goe.1	+	5	834	c.611G>A	c.(610-612)TGG>TAG	p.W204*	uc001gof.1_RNA	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	204	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TGGCAGGTTTGGTTTCAGAAC	0.607													37	159					0	0	0.007835	0	0
XPR1	9213	broad.mit.edu	37	1	180853152	180853152	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:180853152C>T	uc001goi.2	+	15	2233	c.2041C>T	c.(2041-2043)CGT>TGT	p.R681C	XPR1_uc009wxn.2_Missense_Mutation_p.R616C	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	681	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						ATCCAAGGCTCGTGACACTAA	0.378													22	69					0	0	0.003330	0	0
KIAA1614	57710	broad.mit.edu	37	1	180905014	180905014	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:180905014C>T	uc001gok.2	+	5	2036	c.1969C>T	c.(1969-1971)CAC>TAC	p.H657Y	KIAA1614_uc001gol.1_Missense_Mutation_p.H278Y|KIAA1614_uc001gom.1_Intron	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	657										ovary(3)|skin(1)	4						GCCTCGAGGCCACAGGTGGTC	0.667													47	10					0	0	0.002852	0	0
LAMC2	3918	broad.mit.edu	37	1	183196822	183196822	+	Silent	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:183196822C>G	uc001gqa.2	+	10	1772	c.1458C>G	c.(1456-1458)CCC>CCG	p.P486P	LAMC2_uc001gpz.3_Silent_p.P486P|LAMC2_uc010poa.1_Silent_p.P186P	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	486	Laminin EGF-like 6.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						ACTGCCCTCCCGGGGTCACCG	0.587													8	23					0	0	0.003080	0	0
LAMC2	3918	broad.mit.edu	37	1	183206618	183206618	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:183206618G>A	uc001gqa.2	+	18	3047	c.2733G>A	c.(2731-2733)CAG>CAA	p.Q911Q	LAMC2_uc001gpz.3_Silent_p.Q911Q|LAMC2_uc010poa.1_Silent_p.Q611Q	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	911	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						AGCTCTTACAGAATGGAAAAA	0.323													41	18					0	0	0.002222	0	0
EDEM3	80267	broad.mit.edu	37	1	184702001	184702001	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:184702001G>A	uc010pok.1	-	6	843	c.582C>T	c.(580-582)TTC>TTT	p.F194F	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Silent_p.F194F|EDEM3_uc001gqy.2_Silent_p.F117F	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	194					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						TGGTAGTGTTGAAAGCCGGTA	0.353													20	62					0	0	0.002299	0	0
FAM129A	116496	broad.mit.edu	37	1	184787892	184787892	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:184787892C>T	uc001gra.2	-	9	1247	c.1053G>A	c.(1051-1053)CTG>CTA	p.L351L	FAM129A_uc001grb.1_Silent_p.L114L|FAM129A_uc009wyh.1_Silent_p.L179L|FAM129A_uc009wyi.1_Silent_p.L149L	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	351					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						TGAGCTCCTCCAGGATGGATG	0.527													53	207					0	0	0.003610	0	0
HMCN1	83872	broad.mit.edu	37	1	186083184	186083184	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:186083184C>T	uc001grq.1	+	73	11434	c.11205C>T	c.(11203-11205)ATC>ATT	p.I3735I		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3735	Ig-like C2-type 36.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGGAATGCATCGCTGAAGGTG	0.408													82	93					0	0	0.003610	0	0
HMCN1	83872	broad.mit.edu	37	1	186088383	186088384	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:186088383_186088384GG>AA	uc001grq.1	+	78	12138_12139	c.11909_11910GG>AA	c.(11908-11910)AGG>AAA	p.R3970K		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3970	Ig-like C2-type 38.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGTGTCGCTAGGAATGCGGCTG	0.406													35	165					0	0	0.004672	0	0
PRG4	10216	broad.mit.edu	37	1	186281959	186281959	+	Silent	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:186281959T>A	uc001gru.3	+	12	4101	c.4050T>A	c.(4048-4050)GTT>GTA	p.V1350V	PRG4_uc001grt.3_Silent_p.V1309V|PRG4_uc009wyl.2_Silent_p.V1257V|PRG4_uc009wym.2_Silent_p.V1216V|PRG4_uc010poo.1_RNA|TPR_uc001grv.2_3'UTR	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1350					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CAAATGTGGTTACCTCAGCTA	0.388													32	76					0	0	0.002445	0	0
CRB1	23418	broad.mit.edu	37	1	197403878	197403878	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:197403878T>C	uc001gtz.2	+	9	3020	c.2885T>C	c.(2884-2886)TTA>TCA	p.L962S	CRB1_uc010poz.1_Missense_Mutation_p.L938S|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.L850S|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.L443S|CRB1_uc001gub.1_Missense_Mutation_p.L611S	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	962	Extracellular (Potential).|Laminin G-like 3.		Missing (in RP12; without preservation of the paraarteriolar retinal pigment epithelium).		cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GGTCAAATATTATTCAGAAGC	0.308													38	83					0	0	0.008740	0	0
LHX9	56956	broad.mit.edu	37	1	197889123	197889123	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:197889123G>A	uc001guk.1	+	2	633	c.196G>A	c.(196-198)GAG>AAG	p.E66K	LHX9_uc001gui.1_Missense_Mutation_p.E57K|LHX9_uc001guj.1_Missense_Mutation_p.E72K	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	66					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GCTCAGCCCGGAGAAGCCCGC	0.662													35	123					0	0	0.004289	0	0
KIF14	9928	broad.mit.edu	37	1	200571082	200571082	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:200571082G>A	uc010ppk.1	-	11	2533	c.2094C>T	c.(2092-2094)GCC>GCT	p.A698A	KIF14_uc010ppj.1_Silent_p.A207A	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	698					microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						CTATTAAACGGGCTTGGTTAG	0.353													28	111					0	0	0.002096	0	0
KIF21B	23046	broad.mit.edu	37	1	200969679	200969679	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:200969679C>T	uc001gvs.1	-	11	1841	c.1524G>A	c.(1522-1524)CGG>CGA	p.R508R	KIF21B_uc001gvr.1_Silent_p.R508R|KIF21B_uc009wzl.1_Silent_p.R508R|KIF21B_uc010ppn.1_Silent_p.R508R	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	508	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TAGCCGAGGCCCGTGAGAGGC	0.662													18	65					0	0	0.001882	0	0
CACNA1S	779	broad.mit.edu	37	1	201010696	201010696	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:201010696G>A	uc001gvv.2	-	41	5297	c.5070C>T	c.(5068-5070)TTC>TTT	p.F1690F		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1690	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCTCTTCTGGGAACTCCCTTT	0.562													23	11					0	0	0.005443	0	0
TNNT2	7139	broad.mit.edu	37	1	201334796	201334796	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:201334796G>A	uc001gwf.2	-	9	305	c.236C>T	c.(235-237)TCG>TTG	p.S79L	TNNT2_uc001gwg.2_Missense_Mutation_p.S69L|TNNT2_uc001gwh.2_Missense_Mutation_p.S64L|TNNT2_uc001gwi.2_Missense_Mutation_p.S78L|TNNT2_uc009wzr.2_Missense_Mutation_p.S10L|TNNT2_uc001gwj.1_5'Flank|TNNT2_uc009wzs.1_Missense_Mutation_p.S44L|TNNT2_uc001gwk.1_Missense_Mutation_p.S10L|TNNT2_uc009wzt.1_Missense_Mutation_p.S69L	NM_000364	NP_000355	P45379	TNNT2_HUMAN	troponin T type 2, cardiac isoform 1	79					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding				0						GGGCATGAACGACCTGTTGGA	0.567													26	16					0	0	0.006320	0	0
MFSD4	148808	broad.mit.edu	37	1	205549855	205549855	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:205549855G>A	uc001hcv.3	+	3	582	c.496G>A	c.(496-498)GAG>AAG	p.E166K	MFSD4_uc010prk.1_Intron|MFSD4_uc010prl.1_RNA|MFSD4_uc010prm.1_Missense_Mutation_p.E111K	NM_181644	NP_857595	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing	166					transmembrane transport	integral to membrane				skin(2)|central_nervous_system(1)	3	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TTTCCTGTCTGAGGCCAACTG	0.617													110	42					0	0	0.003610	0	0
PM20D1	148811	broad.mit.edu	37	1	205817044	205817044	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:205817044G>A	uc001hdj.2	-	2	270	c.225C>T	c.(223-225)GCC>GCT	p.A75A	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	75						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			ACTCAGCCAGGGCTGTAGTAT	0.423													16	79					0	0	0.007413	0	0
IL20	50604	broad.mit.edu	37	1	207039919	207039919	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:207039919C>T	uc001her.2	+	3	360	c.316C>T	c.(316-318)CTC>TTC	p.L106F	IL20_uc010pry.1_Missense_Mutation_p.L177F|IL20_uc009xby.2_Missense_Mutation_p.L106F	NM_018724	NP_061194	Q9NYY1	IL20_HUMAN	interleukin 20 precursor	106					positive regulation of keratinocyte differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of inflammatory response	extracellular space	cytokine activity|interleukin-20 receptor binding				0	Breast(84;0.201)			OV - Ovarian serous cystadenocarcinoma(81;0.00459)		CCATTATACTCTCCGGAAGAT	0.502													247	91					0	0	0.003610	0	0
PIGR	5284	broad.mit.edu	37	1	207106416	207106416	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:207106416C>T	uc001hez.2	-	7	1985	c.1801G>A	c.(1801-1803)GAT>AAT	p.D601N	PIGR_uc009xbz.2_Missense_Mutation_p.D601N	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	601	Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						AGCCTGGGATCCTGAATGGCT	0.537													26	75					0	0	0.004656	0	0
PFKFB2	5208	broad.mit.edu	37	1	207252345	207252345	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:207252345C>T	uc001hfh.2	+	15	1506	c.1397C>T	c.(1396-1398)TCC>TTC	p.S466F	PFKFB2_uc010psc.1_Missense_Mutation_p.S368F|PFKFB2_uc010psd.1_Missense_Mutation_p.S259F	NM_001018053	NP_001018063	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	Error:Variant_position_missing_in_O60825_after_alignment					fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					TCCGCAGCGTCCCTCATGTTG	0.552													60	200					0	0	0.003610	0	0
CR1	1378	broad.mit.edu	37	1	207785184	207785184	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:207785184C>T	uc001hfy.2	+	30	5248	c.5108C>T	c.(5107-5109)GCC>GTC	p.A1703V	CR1_uc001hfx.2_Missense_Mutation_p.A2153V	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1703	Sushi 26.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						AGCCCTGAAGCCCCTAGATGT	0.532													35	135					0	0	0.005524	0	0
IRF6	3664	broad.mit.edu	37	1	209963884	209963884	+	Missense_Mutation	SNP	C	T	T	rs121434231		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:209963884C>T	uc001hhq.1	-	7	1279	c.1016G>A	c.(1015-1017)AGA>AAA	p.R339K	IRF6_uc010psm.1_Missense_Mutation_p.R244K|IRF6_uc009xct.1_Missense_Mutation_p.R339K	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	339			R -> I (in VWS).		cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CTTCTTTTGTCTCTCAATCAG	0.478										HNSCC(57;0.16)			19	80					0	0	0.007413	0	0
SERTAD4	56256	broad.mit.edu	37	1	210415625	210415625	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:210415625A>T	uc001hhy.2	+	4	1193	c.1014A>T	c.(1012-1014)AAA>AAT	p.K338N	SERTAD4_uc009xcw.2_Missense_Mutation_p.K338N	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	338							protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		CCTTACGGAAAAAGGAGGCTT	0.388													21	64					0	0	0.001882	0	0
PTPN14	5784	broad.mit.edu	37	1	214556883	214556883	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:214556883G>A	uc001hkk.1	-	13	2586	c.2315C>T	c.(2314-2316)CCT>CTT	p.P772L	PTPN14_uc010pty.1_Missense_Mutation_p.P673L	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	772					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CATGGCGGGAGGAAGGCTGGC	0.682													7	43					0	0	0.003080	0	0
KCNK2	3776	broad.mit.edu	37	1	215259779	215259779	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:215259779A>C	uc001hkq.2	+	2	284	c.115A>C	c.(115-117)ACG>CCG	p.T39P	KCNK2_uc001hko.2_Missense_Mutation_p.T35P|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.T24P	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	39	Cytoplasmic (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CTCGTTTTCCACGAAACCCAC	0.512													53	15					0	0	0.003610	0	0
USH2A	7399	broad.mit.edu	37	1	216258115	216258115	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:216258115C>T	uc001hku.1	-	25	5479	c.5092G>A	c.(5092-5094)GAA>AAA	p.E1698K		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1698	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTGATTTGTTCTTCAGAACTC	0.423										HNSCC(13;0.011)			27	82					0	0	0.004656	0	0
IARS2	55699	broad.mit.edu	37	1	220312443	220312443	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:220312443C>A	uc001hmc.2	+	18	2373	c.2269C>A	c.(2269-2271)CAG>AAG	p.Q757K	IARS2_uc001hmd.2_Missense_Mutation_p.Q93K	NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	757					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	TGTCATAGACCAGTACATGCT	0.348													20	58					1.01871e-10	1.55048e-10	0.008871	1	0
HLX	3142	broad.mit.edu	37	1	221057631	221057631	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:221057631C>T	uc001hmv.3	+	4	1509	c.1052C>T	c.(1051-1053)CCA>CTA	p.P351L		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	351					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		GGCGAGAAGCCATCAGGTGGA	0.657													46	23					0	0	0.003610	0	0
MIA3	375056	broad.mit.edu	37	1	222798135	222798135	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:222798135C>T	uc001hnl.2	+	3	302	c.293C>T	c.(292-294)CCA>CTA	p.P98L	MIA3_uc009xea.1_5'Flank	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	98	SH3.|Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		GGATATTTTCCAAAAGATTTA	0.333													358	208					0	0	0.003610	0	0
NUP133	55746	broad.mit.edu	37	1	229623321	229623321	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:229623321A>C	uc001htn.2	-	10	1326	c.1234T>G	c.(1234-1236)TTT>GTT	p.F412V		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	412					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				TGGTTTGAAAAGTTTGGGACC	0.348													88	41					0	0	0.003610	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394984	233394984	+	Silent	SNP	C	T	T	rs117316984	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:233394984C>T	uc001hvl.2	-	5	859	c.624G>A	c.(622-624)ACG>ACA	p.T208T	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	208						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CTGACTTGGTCGTGGTTTCCA	0.478													70	73					0	0	0.003610	0	0
LYST	1130	broad.mit.edu	37	1	235904728	235904728	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:235904728G>A	uc001hxj.2	-	31	8527	c.8352C>T	c.(8350-8352)TCC>TCT	p.S2784S	LYST_uc009xga.1_Silent_p.S420S	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2784					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTACTTGTAGGGATGGGCTGA	0.373									Chediak-Higashi_syndrome				23	125					0	0	0.006320	0	0
ERO1LB	56605	broad.mit.edu	37	1	236384259	236384259	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:236384259C>T	uc001hxt.2	-	15	1472	c.1216G>A	c.(1216-1218)GGT>AGT	p.G406S		NM_019891	NP_063944	Q86YB8	ERO1B_HUMAN	endoplasmic reticulum oxidoreductin 1-Lbeta	406					electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding				0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			GTTCCTAAACCCTGAGTCTAA	0.333													11	46					0	0	0.000978	0	0
HEATR1	55127	broad.mit.edu	37	1	236746319	236746319	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:236746319G>A	uc001hyd.1	-	18	2544	c.2419C>T	c.(2419-2421)CCT>TCT	p.P807S	HEATR1_uc009xgh.1_Missense_Mutation_p.P50S	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	807					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTACCTTTAGGAAAAGATTTA	0.383													59	30					0	0	0.003610	0	0
FMN2	56776	broad.mit.edu	37	1	240371666	240371666	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:240371666C>T	uc010pyd.1	+	5	3779	c.3554C>T	c.(3553-3555)CCT>CTT	p.P1185L	FMN2_uc010pye.1_Missense_Mutation_p.P1189L	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1185	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GTGGGAATACCTCCTCCGCCC	0.682													10	1					0	0	0.001855	0	0
KIF26B	55083	broad.mit.edu	37	1	245851531	245851531	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:245851531C>T	uc001ibf.1	+	12	5686	c.5246C>T	c.(5245-5247)TCC>TTC	p.S1749F	KIF26B_uc001ibg.1_Missense_Mutation_p.S1367F|KIF26B_uc001ibh.1_Missense_Mutation_p.S991F	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1749	Ser-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CGCGGCCCGTCCGCCTCCACC	0.731													4	26					0	0	0.001168	0	0
ZNF670	93474	broad.mit.edu	37	1	247200784	247200784	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:247200784G>A	uc001icd.1	-	4	1308	c.1137C>T	c.(1135-1137)TCC>TCT	p.S379S	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	379	C2H2-type 9; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			GCTTTCGAAGGGAACTGGAAC	0.378													29	76					0	0	0.007291	0	0
ZNF496	84838	broad.mit.edu	37	1	247463992	247463992	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:247463992G>A	uc001ico.2	-	9	2058	c.1593C>T	c.(1591-1593)TTC>TTT	p.F531F	ZNF496_uc009xgv.2_Silent_p.F567F|ZNF496_uc001icp.2_Silent_p.F531F	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	531	C2H2-type 4.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			CGTGCCGCTGGAAGGCCTTCC	0.627													88	38					0	0	0.003610	0	0
OR2G2	81470	broad.mit.edu	37	1	247752336	247752336	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:247752336C>T	uc010pyy.1	+	1	675	c.675C>T	c.(673-675)GCC>GCT	p.A225A		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCTACATTGCCCACGCAGTGT	0.433													16	94					0	0	0.004007	0	0
OR2L13	284521	broad.mit.edu	37	1	248263371	248263371	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:248263371G>A	uc001ids.2	+	3	1031	c.694G>A	c.(694-696)GGG>AGG	p.G232R		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding	p.G232E(1)		central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CTCAAAGGAGGGGAGAAAAAA	0.433													26	79					0	0	0.004656	0	0
OR2M3	127062	broad.mit.edu	37	1	248367286	248367286	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:248367286G>A	uc010pzg.1	+	1	917	c.917G>A	c.(916-918)GGA>GAA	p.G306E		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AAGATCTTAGGAAAGGGCAAG	0.418													14	100					0	0	0.003163	0	0
OR2T1	26696	broad.mit.edu	37	1	248570074	248570074	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:248570074C>T	uc010pzm.1	+	1	779	c.779C>T	c.(778-780)CCT>CTT	p.P260L		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	260	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGCTGATTCCTTTCTCTGTA	0.507													18	66					0	0	0.006122	0	0
OR2T27	403239	broad.mit.edu	37	1	248814064	248814064	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:248814064C>T	uc010pzo.1	-	1	122	c.122G>A	c.(121-123)AGC>AAC	p.S41N		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GACCACGTTGCTGGCTATGGA	0.522													12	57					0	0	0.003163	0	0
IDI2	91734	broad.mit.edu	37	10	1070537	1070537	+	Missense_Mutation	SNP	C	T	T	rs61738901		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:1070537C>T	uc001ifv.1	-	2	192	c.127G>A	c.(127-129)GAA>AAA	p.E43K	C10orf110_uc010qaf.1_Intron|C10orf110_uc001ifx.3_Intron|C10orf110_uc001ifw.3_Intron|C10orf110_uc001ify.3_Intron	NM_033261	NP_150286	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	43					carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding				0		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		TCAATGTTTTCGTTCAGATGG	0.498													15	14					0	0	0.003163	0	0
ACBD7	414149	broad.mit.edu	37	10	15058979	15058979	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:15058979A>G	uc010qby.1	-	7	521	c.212T>C	c.(211-213)GTT>GCT	p.V71A				Q8N6N7	ACBD7_HUMAN	SubName: Full=cDNA FLJ52263, highly similar to Artemis protein (EC 3.1.-.-);	Error:Variant_position_missing_in_Q8N6N7_after_alignment							fatty-acyl-CoA binding				0						CAGCCACACAACATGGTACAG	0.423													3	122					0	0	0.004672	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255082	15255082	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:15255082C>T	uc001iob.2	-	8	2512	c.2505G>A	c.(2503-2505)ACG>ACA	p.T835T		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	835	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						TCCGTCTGGTCGTCTCCTCCT	0.637													37	42					0	0	0.004878	0	0
ITGA8	8516	broad.mit.edu	37	10	15614220	15614220	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:15614220T>C	uc001ioc.1	-	25	2627	c.2627A>G	c.(2626-2628)CAG>CGG	p.Q876R	ITGA8_uc010qcb.1_Missense_Mutation_p.Q861R	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	876	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						CTTTATATCCTGTGGATTGAT	0.383													23	39					0	0	0.005443	0	0
CACNB2	783	broad.mit.edu	37	10	18690937	18690937	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:18690937G>A	uc001ipr.2	+	3	358	c.298G>A	c.(298-300)GAG>AAG	p.E100K	CACNB2_uc009xjz.1_Missense_Mutation_p.E100K|CACNB2_uc001ips.2_Missense_Mutation_p.E100K|CACNB2_uc001ipt.2_Missense_Mutation_p.E100K|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Missense_Mutation_p.E72K|CACNB2_uc001ipv.2_Missense_Mutation_p.E72K|CACNB2_uc009xka.1_Missense_Mutation_p.E72K|CACNB2_uc001ipw.2_Missense_Mutation_p.E45K|CACNB2_uc001ipx.2_Missense_Mutation_p.E45K|CACNB2_uc009xkb.1_Missense_Mutation_p.E46K|CACNB2_uc010qcm.1_Missense_Mutation_p.E46K|CACNB2_uc001ipz.2_Missense_Mutation_p.E46K|CACNB2_uc001ipy.2_Missense_Mutation_p.E46K|CACNB2_uc010qcn.1_Missense_Mutation_p.E52K|CACNB2_uc010qco.1_Missense_Mutation_p.E52K|CACNB2_uc001iqa.2_Missense_Mutation_p.E52K	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	100				ER -> Q (in Ref. 3; AAD33729).	axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CAGAGAAGCGGAGCGGCAGGC	0.552													10	29					0	0	0.008291	0	0
NEBL	10529	broad.mit.edu	37	10	21106570	21106570	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:21106570C>T	uc001iqi.2	-	21	2504	c.2107G>A	c.(2107-2109)GAG>AAG	p.E703K	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	703	Nebulin 20.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CTCTTCAGCTCTGGTGGATCA	0.378													20	47					0	0	0.003330	0	0
LOC387647	387647	broad.mit.edu	37	10	29710357	29710357	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:29710357C>T	uc001ium.2	+	3		c.1124C>T			LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|LOC387647_uc001iun.2_RNA					Homo sapiens cDNA FLJ31518 fis, clone NT2RI2000064.												0						AAATCTTCCTCGTCCCTCCCA	0.483													16	16					0	0	0.008871	0	0
Unknown	0	broad.mit.edu	37	10	30998298	30998298	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:30998298G>A	uc010qdx.1	+	8	1386	c.844G>A	c.(844-846)GAG>AAG	p.E282K						SubName: Full=cDNA FLJ59642, highly similar to Supervillin;																		CGCAGCCACGGAGTTCGTGTA	0.577													18	19					0	0	0.001523	0	0
ZEB1	6935	broad.mit.edu	37	10	31791374	31791374	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:31791374C>T	uc001ivs.3	+	4	481	c.418C>T	c.(418-420)CCT>TCT	p.P140S	ZEB1_uc001ivr.3_5'UTR|ZEB1_uc010qee.1_5'UTR|ZEB1_uc010qef.1_5'UTR|ZEB1_uc009xlh.1_RNA|ZEB1_uc009xli.1_RNA|ZEB1_uc009xlj.1_Intron|ZEB1_uc010qeg.1_Intron|ZEB1_uc009xlk.1_5'UTR|ZEB1_uc001ivt.3_5'UTR|ZEB1_uc001ivu.3_Missense_Mutation_p.P141S|ZEB1_uc001ivv.3_Missense_Mutation_p.P120S|ZEB1_uc010qeh.1_Missense_Mutation_p.P73S|ZEB1_uc009xll.2_RNA|ZEB1_uc009xlm.1_RNA|ZEB1_uc009xln.1_RNA|ZEB1_uc009xlo.1_Missense_Mutation_p.P123S|ZEB1_uc009xlp.2_Missense_Mutation_p.P124S	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	140					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				TGTCATTTTTCCTGAGGCACC	0.423													36	53					0	0	0.004289	0	0
ZEB1	6935	broad.mit.edu	37	10	31810768	31810768	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:31810768G>A	uc001ivs.3	+	7	2568	c.2505G>A	c.(2503-2505)ACG>ACA	p.T835T	ZEB1_uc001ivr.3_Silent_p.T617T|ZEB1_uc010qee.1_Silent_p.T617T|ZEB1_uc010qef.1_Silent_p.T617T|ZEB1_uc009xlj.1_Silent_p.T761T|ZEB1_uc010qeg.1_Silent_p.T694T|ZEB1_uc009xlk.1_Silent_p.T617T|ZEB1_uc001ivt.3_Silent_p.T617T|ZEB1_uc001ivu.3_Silent_p.T836T|ZEB1_uc001ivv.3_Silent_p.T815T|ZEB1_uc010qeh.1_Silent_p.T768T|ZEB1_uc009xlo.1_Silent_p.T818T|ZEB1_uc009xlp.2_Silent_p.T819T	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	835					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				ATAAGCAAACGATTCTGATTC	0.498													23	26					0	0	0.004656	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37436309	37436309	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:37436309G>A	uc001iza.1	+	9	1398	c.1299G>A	c.(1297-1299)GAG>GAA	p.E433E		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	489						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GTCTCTTTGAGAGTTCTGCAA	0.254													11	27					0	0	0.002450	0	0
ZNF37B	100129482	broad.mit.edu	37	10	43016537	43016537	+	RNA	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:43016537A>G	uc001jab.3	-	5		c.2663T>C			ZNF37B_uc001jac.3_RNA|ZNF37B_uc001jaa.3_RNA					Homo sapiens cDNA: FLJ23327 fis, clone HEP12630, highly similar to HSZNF37 Homo sapiens ZNF37A mRNA for zinc finger protein.												0						AACTCATTGAACTTCATTCTT	0.313													22	42					0	0	0.003330	0	0
ALOX5	240	broad.mit.edu	37	10	45924071	45924071	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:45924071G>A	uc001jce.2	+	7	939	c.840G>A	c.(838-840)GGG>GGA	p.G280G	ALOX5_uc009xmt.2_Silent_p.G280G|ALOX5_uc010qfg.1_Silent_p.G280G	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	280	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	TGCAGCAAGGGAACATTTTCA	0.552													10	17					0	0	0.002450	0	0
FAM21B	55747	broad.mit.edu	37	10	47909783	47909783	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:47909783C>T	uc009xni.2	+	11	880	c.880C>T	c.(880-882)CCC>TCC	p.P294S	FAM21B_uc001jep.3_Missense_Mutation_p.P189S	NM_018232	NP_060702	Q5SNT6	FA21B_HUMAN	hypothetical protein LOC55747	294					retrograde transport, endosome to Golgi	early endosome membrane|WASH complex				ovary(1)	1						CACGGAAGCCCCCCAGGATCG	0.493													4	1					0	0	0.003163	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49687791	49687791	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:49687791C>T	uc001jgt.2	-	4	636	c.339G>A	c.(337-339)CGG>CGA	p.R113R	ARHGAP22_uc001jgs.2_Silent_p.R23R|ARHGAP22_uc001jgu.2_Silent_p.R113R|ARHGAP22_uc010qgl.1_Intron|ARHGAP22_uc010qgm.1_Silent_p.R119R|ARHGAP22_uc001jgv.2_5'UTR|uc001jgw.2_5'Flank	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	113	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						GCACCTTCTCCCGCTCCCCGG	0.677													4	4					0	0	0.000248	0	0
C10orf71	118461	broad.mit.edu	37	10	50531928	50531928	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:50531928C>T	uc010qgp.1	+	3	1677	c.1338C>T	c.(1336-1338)CTC>CTT	p.L446L		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	446											0						TCAGTAAGCTCCTGACCCCCA	0.522													18	25					0	0	0.006122	0	0
ASAH2	56624	broad.mit.edu	37	10	52008332	52008332	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:52008332C>T	uc001jjd.2	-	1	39	c.39G>A	c.(37-39)CTG>CTA	p.L13L	ASAH2_uc009xos.2_Silent_p.L13L	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	13	Helical; Signal-anchor for type II membrane protein; (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						GGAGGAAAATCAGGAATGTCT	0.433													14	25					0	0	0.003163	0	0
Unknown	0	broad.mit.edu	37	10	52390795	52390795	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:52390795C>T	uc001jjf.1	+	2		c.1488C>T								Homo sapiens cDNA FLJ12320 fis, clone MAMMA1002082.																		GGTAAAAATTCCTTTATCTGC	0.488													4	12					0	0	0.000248	0	0
DKK1	22943	broad.mit.edu	37	10	54074346	54074346	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:54074346G>A	uc001jjr.2	+	1	306	c.152G>A	c.(151-153)GGC>GAC	p.G51D	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor	51					negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						CCGCTGGGCGGCGCTGCGGGG	0.657											OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	26					0	0	0.002450	0	0
PCDH15	65217	broad.mit.edu	37	10	55944921	55944921	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:55944921C>T	uc001jju.1	-	12	1808	c.1413G>A	c.(1411-1413)AGG>AGA	p.R471R	PCDH15_uc010qhq.1_Silent_p.R476R|PCDH15_uc010qhr.1_Silent_p.R471R|PCDH15_uc010qhs.1_Silent_p.R483R|PCDH15_uc010qht.1_Silent_p.R478R|PCDH15_uc010qhu.1_Silent_p.R471R|PCDH15_uc001jjv.1_Silent_p.R449R|PCDH15_uc010qhv.1_Silent_p.R471R|PCDH15_uc010qhw.1_Silent_p.R434R|PCDH15_uc010qhx.1_Silent_p.R471R|PCDH15_uc010qhy.1_Silent_p.R476R|PCDH15_uc010qhz.1_Silent_p.R471R|PCDH15_uc010qia.1_Silent_p.R449R|PCDH15_uc010qib.1_Silent_p.R449R|PCDH15_uc001jjw.2_Silent_p.R471R	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	471	Cadherin 4.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GCTGTTCTTCCCTGTCCACTG	0.353										HNSCC(58;0.16)			25	26					0	0	0.004656	0	0
FAM13C	220965	broad.mit.edu	37	10	61022203	61022203	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:61022203C>T	uc001jkn.2	-	11	1361	c.1227G>A	c.(1225-1227)GAG>GAA	p.E409E	FAM13C_uc001jko.2_Intron|FAM13C_uc010qid.1_Silent_p.E326E|FAM13C_uc010qie.1_Silent_p.E326E|FAM13C_uc010qif.1_Silent_p.E431E|FAM13C_uc001jkp.2_Silent_p.E326E	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	409										ovary(2)	2						CCTTAGAATCCTCCTGGGGAG	0.517													13	17					0	0	0.004007	0	0
SLC16A9	220963	broad.mit.edu	37	10	61413888	61413888	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:61413888G>A	uc010qig.1	-	5	1345	c.896C>T	c.(895-897)GCT>GTT	p.A299V		NM_194298	NP_919274	Q7RTY1	MOT9_HUMAN	solute carrier family 16 (monocarboxylic acid	299	Extracellular (Potential).				urate metabolic process	integral to membrane|plasma membrane	symporter activity	p.A299A(1)		skin(2)|ovary(1)	3						TTTAAAAAGAGCCACAGTTTC	0.368													30	33					0	0	0.007291	0	0
ANK3	288	broad.mit.edu	37	10	61829952	61829952	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:61829952C>T	uc001jky.2	-	37	10879	c.10687G>A	c.(10687-10689)GAA>AAA	p.E3563K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3563					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGCTTAGTTTCATCTTCCCGT	0.468													26	23					0	0	0.008361	0	0
ANK3	288	broad.mit.edu	37	10	61835777	61835777	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:61835777G>A	uc001jky.2	-	37	5054	c.4862C>T	c.(4861-4863)TCC>TTC	p.S1621F	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1621	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGTTCGAGAGGAAAACGTAGA	0.478													24	32					0	0	0.003954	0	0
ANK3	288	broad.mit.edu	37	10	61898772	61898772	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:61898772G>A	uc001jky.2	-	24	2880	c.2688C>T	c.(2686-2688)TCC>TCT	p.S896S	ANK3_uc001jkw.2_Silent_p.S30S|ANK3_uc009xpa.2_Silent_p.S30S|ANK3_uc001jkx.2_Silent_p.S74S|ANK3_uc010qih.1_Silent_p.S897S|ANK3_uc001jkz.3_Silent_p.S890S|ANK3_uc001jlb.1_Silent_p.S404S|ANK3_uc001jlc.1_Silent_p.S536S	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	896					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CTGCAGGCAGGGAATCATCAC	0.468													25	27					0	0	0.003330	0	0
TET1	80312	broad.mit.edu	37	10	70405173	70405173	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:70405173C>T	uc001jok.3	+	4	3192	c.2687C>T	c.(2686-2688)GCC>GTC	p.A896V		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	896					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						GCCATAGAGGCCCTGACTCAA	0.448													43	62					0	0	0.003610	0	0
TET1	80312	broad.mit.edu	37	10	70441247	70441247	+	Splice_Site	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:70441247T>G	uc001jok.3	+	9	5419	c.4914_splice	c.e9+2	p.Q1638_splice		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6						DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						CAAAATCAGGTATGTATTGGT	0.209													6	15					0	0	0.001168	0	0
PRF1	5551	broad.mit.edu	37	10	72358711	72358712	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:72358711_72358712CC>TT	uc009xqg.2	-	3	926_927	c.765_766GG>AA	c.(763-768)GAGGAC>GAAAAC	p.D256N	PRF1_uc001jrf.3_Missense_Mutation_p.D256N	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	256	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						GTCAGGCAGTCCTCCACCTCGT	0.619			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				10	22					0	0	0.004672	0	0
PRF1	5551	broad.mit.edu	37	10	72360558	72360558	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:72360558C>T	uc009xqg.2	-	2	262	c.101G>A	c.(100-102)AGC>AAC	p.S34N	PRF1_uc001jrf.3_Missense_Mutation_p.S34N	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	34	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						GAACTTGTGGCTGCGCTTGCA	0.677			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				7	14					0	0	0.001984	0	0
SEC24C	9632	broad.mit.edu	37	10	75529739	75529739	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:75529739C>T	uc001juw.2	+	21	3007	c.2828C>T	c.(2827-2829)ACC>ATC	p.T943I	SEC24C_uc001jux.2_Missense_Mutation_p.T943I|SEC24C_uc010qko.1_Missense_Mutation_p.T824I|SEC24C_uc010qkp.1_Missense_Mutation_p.T191I|SEC24C_uc010qkq.1_Missense_Mutation_p.T191I|FUT11_uc001juy.1_5'Flank|FUT11_uc001juz.1_5'Flank|FUT11_uc001jva.2_5'Flank	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	943					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					GTGACTGAGACCAATGTCTTC	0.512													51	81					0	0	0.003610	0	0
SFTPD	6441	broad.mit.edu	37	10	81697941	81697941	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:81697941G>A	uc001kbh.2	-	8	838	c.795C>T	c.(793-795)TTC>TTT	p.F265F	MBL1P_uc001kbf.2_Intron	NM_003019	NP_003010	P35247	SFTPD_HUMAN	pulmonary surfactant-associated protein D	265	C-type lectin.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			skin(1)	1	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			CTGCTGTCTTGAAAATCTTCT	0.542													20	36					0	0	0.001523	0	0
CDHR1	92211	broad.mit.edu	37	10	85972966	85972966	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:85972966C>T	uc001kcv.2	+	16	1902	c.1902C>T	c.(1900-1902)TCC>TCT	p.S634S	CDHR1_uc001kcw.2_Silent_p.S634S|CDHR1_uc009xst.2_Silent_p.S338S|CDHR1_uc001kcx.2_5'UTR	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	634	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						TCAAGAATTCCATCCGCTCCC	0.582													30	36					0	0	0.001786	0	0
OPN4	94233	broad.mit.edu	37	10	88416026	88416026	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:88416026G>A	uc001kdq.2	+	2	486	c.259G>A	c.(259-261)GGC>AGC	p.G87S	OPN4_uc001kdp.2_Missense_Mutation_p.G87S|OPN4_uc010qmk.1_Missense_Mutation_p.G87S	NM_033282	NP_150598	Q9UHM6	OPN4_HUMAN	opsin 4 isoform 1	87	Helical; Name=1; (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			ovary(1)	1						GGGGATGCTGGGCAACCTGAC	0.612													33	51					0	0	0.004878	0	0
PAPSS2	9060	broad.mit.edu	37	10	89475534	89475534	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:89475534C>T	uc001kex.2	+	7	1062	c.799C>T	c.(799-801)CCC>TCC	p.P267S	PAPSS2_uc001kew.2_Missense_Mutation_p.P267S|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	267	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CTGGGCCACTCCCCTCAAAGG	0.443													25	35					0	0	0.005443	0	0
LIPF	8513	broad.mit.edu	37	10	90436022	90436022	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:90436022G>A	uc001kfg.1	+	9	1111	c.945G>A	c.(943-945)AGG>AGA	p.R315R	LIPF_uc001kfh.1_Silent_p.R292R|LIPF_uc010qmt.1_Silent_p.R325R|LIPF_uc010qmu.1_Silent_p.R282R	NM_004190	NP_004181	P07098	LIPG_HUMAN	lipase, gastric precursor	315					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity				0		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		TTCAGAATAGGATGCACTATG	0.303													16	19					0	0	0.007413	0	0
SLC16A12	387700	broad.mit.edu	37	10	91222222	91222222	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:91222222C>T	uc001kgm.2	-	3	415	c.24G>A	c.(22-24)CGG>CGA	p.R8R		NM_213606	NP_998771	Q6ZSM3	MOT12_HUMAN	solute carrier family 16 (monocarboxylic acid	8	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			skin(1)	1						GGGAGGTAGACCGAGCTCTAT	0.478													24	52					0	0	0.008361	0	0
GPR120	338557	broad.mit.edu	37	10	95347351	95347351	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:95347351G>A	uc010qnt.1	+	4	1175	c.1119G>A	c.(1117-1119)TCG>TCA	p.S373S	GPR120_uc010qnu.1_Silent_p.S357S	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	G protein-coupled receptor 120	373	Cytoplasmic (Potential).				negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding				0		Colorectal(252;0.122)				ATGACTTGTCGATTATTTCTG	0.418													33	24					0	0	0.003755	0	0
PDE6C	5146	broad.mit.edu	37	10	95372854	95372854	+	Silent	SNP	G	A	A	rs147367341		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:95372854G>A	uc001kiu.3	+	1	510	c.372G>A	c.(370-372)GAG>GAA	p.E124E		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	124	GAF 1.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				CCAAGTTTGAGGACAACCTGG	0.552													20	26					0	0	0.008871	0	0
ENTPD1	953	broad.mit.edu	37	10	97602187	97602187	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:97602187C>T	uc001klh.3	+	4	673	c.349C>T	c.(349-351)CCA>TCA	p.P117S	ENTPD1_uc001kle.1_Missense_Mutation_p.P124S|ENTPD1_uc001kli.3_Missense_Mutation_p.P124S|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Missense_Mutation_p.P129S|ENTPD1_uc010qok.1_Missense_Mutation_p.P9S|ENTPD1_uc010qol.1_Missense_Mutation_p.P9S|ENTPD1_uc010qom.1_Missense_Mutation_p.P117S|ENTPD1_uc010qon.1_Intron|ENTPD1_uc009xva.2_Intron|ENTPD1_uc009xuz.2_RNA	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	117	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		GGAAGTGATTCCAAGGTCCCA	0.473													29	48					0	0	0.001786	0	0
RRP12	23223	broad.mit.edu	37	10	99141234	99141234	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:99141234G>A	uc001knf.2	-	12	1466	c.1327C>T	c.(1327-1329)CTG>TTG	p.L443L	RRP12_uc009xvm.2_Silent_p.L161L|RRP12_uc010qou.1_Silent_p.L382L|RRP12_uc009xvn.2_Silent_p.L343L	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	443						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CATTCCTTCAGGATCTCCTGC	0.597													9	6					0	0	0.000978	0	0
CRTAC1	55118	broad.mit.edu	37	10	99770962	99770962	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:99770962G>A	uc001kou.1	-	2	513	c.157C>T	c.(157-159)CAG>TAG	p.Q53*	CRTAC1_uc001kov.2_Nonsense_Mutation_p.Q42*	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	53	FG-GAP 1; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		TAGTTGAGCTGGGTGGGATTA	0.547													32	47					0	0	0.002445	0	0
GBF1	8729	broad.mit.edu	37	10	104103904	104103904	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:104103904C>T	uc001kux.1	+	4	500	c.260C>T	c.(259-261)ACC>ATC	p.T87I	GBF1_uc001kuw.2_Missense_Mutation_p.T87I|GBF1_uc001kuy.1_Missense_Mutation_p.T87I|GBF1_uc001kuz.1_Missense_Mutation_p.T87I	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	87					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CTGGCACTCACCTCTGTCAAC	0.498													33	52					0	0	0.003271	0	0
CYP17A1	1586	broad.mit.edu	37	10	104596920	104596920	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:104596920G>A	uc001kwg.2	-	1	371	c.199C>T	c.(199-201)CGT>TGT	p.R67C		NM_000102	NP_000093	P05093	CP17A_HUMAN	cytochrome P450, family 17	67					androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity				0		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	GTGCCCATACGAACCGAATAG	0.542													27	51					0	0	0.002096	0	0
COL17A1	1308	broad.mit.edu	37	10	105798213	105798213	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:105798213G>A	uc001kxr.2	-	45	3190	c.3021C>T	c.(3019-3021)ATC>ATT	p.I1007I		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1007	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CAGAGCTGCTGATAGAGCCCG	0.597													106	59					0	0	0.003610	0	0
SORCS1	114815	broad.mit.edu	37	10	108339231	108339231	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:108339231G>A	uc001kym.2	-	25	3275	c.3267C>T	c.(3265-3267)GCC>GCT	p.A1089A	SORCS1_uc001kyl.2_Silent_p.A1089A|SORCS1_uc009xxs.2_Silent_p.A1089A|SORCS1_uc001kyn.1_Silent_p.A1089A|SORCS1_uc001kyo.2_Silent_p.A1089A	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1089	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CCACCAGGGGGGCTTGTGGGG	0.522													13	32					0	0	0.001368	0	0
C10orf81	79949	broad.mit.edu	37	10	115526193	115526193	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:115526193G>A	uc001lat.1	+	2	596	c.34G>A	c.(34-36)GAA>AAA	p.E12K	C10orf81_uc001lar.1_Missense_Mutation_p.E18K|C10orf81_uc009xyc.1_5'UTR|C10orf81_uc001las.1_Intron	NM_024889	NP_079165	Q5SXH7	CJ081_HUMAN	hypothetical protein LOC79949	12										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		ATTTTCTTATGAAAATGAAGT	0.348													16	40					0	0	0.004007	0	0
VWA2	340706	broad.mit.edu	37	10	116049153	116049153	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:116049153G>A	uc001lbl.1	+	12	2348	c.2027G>A	c.(2026-2028)CGG>CAG	p.R676Q	VWA2_uc001lbk.1_Missense_Mutation_p.R676Q|VWA2_uc009xyf.1_Missense_Mutation_p.R372Q	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	676	VWFA 3.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		GAGGGTCTGCGGAGGCTTGCA	0.622													7	31					0	0	0.004482	0	0
C10orf46	143384	broad.mit.edu	37	10	120450808	120450808	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:120450808G>A	uc001lds.1	-	7	1478	c.994C>T	c.(994-996)CAA>TAA	p.Q332*	C10orf46_uc010qst.1_RNA	NM_153810	NP_722517	Q86Y37	CJ046_HUMAN	chromosome 10 open reading frame 46	332					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding				0		Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0131)		AGTTCTCTTTGAAATTTCTGA	0.388													71	94					0	0	0.003610	0	0
DMBT1	1755	broad.mit.edu	37	10	124352006	124352006	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:124352006G>A	uc001lgk.1	+	20	2501	c.2395G>A	c.(2395-2397)GAT>AAT	p.D799N	DMBT1_uc001lgl.1_Missense_Mutation_p.D789N|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Missense_Mutation_p.D799N|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Missense_Mutation_p.D412N	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	799	SRCR 6.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGTTCTGGATGATGTGCGCTG	0.607													47	55					0	0	0.003214	0	0
ADAM12	8038	broad.mit.edu	37	10	127755327	127755328	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:127755327_127755328CC>TT	uc001ljk.2	-	13	1793_1794	c.1380_1381GG>AA	c.(1378-1383)CCGGAC>CCAAAC	p.D461N	ADAM12_uc010qul.1_Missense_Mutation_p.D412N|ADAM12_uc001ljm.2_Missense_Mutation_p.D461N|ADAM12_uc001ljn.2_Missense_Mutation_p.D458N|ADAM12_uc001ljl.3_Missense_Mutation_p.D458N	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	461	Extracellular (Potential).|Disintegrin.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CACACAGCGTCCGGCTTCAGGG	0.55													11	18					0	0	0.004672	0	0
FOXI2	399823	broad.mit.edu	37	10	129537088	129537088	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:129537088C>T	uc009yas.2	+	2	816	c.816C>T	c.(814-816)TTC>TTT	p.F272F	uc009yar.1_5'Flank	NM_207426	NP_997309	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	272					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				ACTTTTCTTTCGGGAGGCGGC	0.716													4	8					0	0	0.000248	0	0
EBF3	253738	broad.mit.edu	37	10	131761695	131761695	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:131761695T>C	uc001lki.1	-	2	286	c.227A>G	c.(226-228)GAT>GGT	p.D76G	EBF3_uc010qur.1_Missense_Mutation_p.D62G	NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	76					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCCCTGCCTATCGTAGAGCGC	0.572													39	60					0	0	0.002222	0	0
GLRX3	10539	broad.mit.edu	37	10	131958313	131958313	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:131958313C>T	uc001lkm.1	+	3	278	c.256C>T	c.(256-258)CCC>TCC	p.P86S	GLRX3_uc001lkn.1_Missense_Mutation_p.P86S|GLRX3_uc001lko.2_RNA	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3	86	Thioredoxin.				cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		TAGCTCTGTTCCCACTTTTCT	0.358													39	65					0	0	0.002522	0	0
TCERG1L	256536	broad.mit.edu	37	10	133107460	133107460	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:133107460G>A	uc001lkp.2	-	2	531	c.445C>T	c.(445-447)CCT>TCT	p.P149S		NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	149	WW 1.									large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		TTCCCAATAGGGGTTGCAAGA	0.478													15	22					0	0	0.004007	0	0
ATHL1	80162	broad.mit.edu	37	11	294569	294569	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:294569C>T	uc010qvu.1	+	14	2149	c.2034C>T	c.(2032-2034)TCC>TCT	p.S678S	ATHL1_uc001lor.3_Silent_p.S430S|ATHL1_uc001lou.3_Silent_p.S253S|ATHL1_uc001lov.3_Silent_p.S139S	NM_025092	NP_079368	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1	678					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			liver(1)|central_nervous_system(1)|skin(1)	3		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		ACAAGGTCTCCTTTCCCCGCT	0.627													37	29					0	0	0.006230	0	0
CDHR5	53841	broad.mit.edu	37	11	617422	617422	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:617422C>T	uc001lqj.2	-	15	2572	c.2467G>A	c.(2467-2469)GAT>AAT	p.D823N	IRF7_uc009ycb.2_5'Flank|IRF7_uc010qwf.1_5'Flank|IRF7_uc001lqf.2_5'Flank|IRF7_uc010qwg.1_5'Flank|IRF7_uc001lqg.2_5'Flank|IRF7_uc001lqh.2_5'Flank|IRF7_uc001lqi.2_5'Flank|IRF7_uc010qwh.1_5'Flank|CDHR5_uc001lqk.2_Missense_Mutation_p.D629N|CDHR5_uc009ycc.2_Missense_Mutation_p.D657N|CDHR5_uc009ycd.2_Missense_Mutation_p.D817N|CDHR5_uc001lql.2_Missense_Mutation_p.D823N	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	823	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TCGCCCTCATCGCCGCTGCCG	0.692													4	5					0	0	0.000602	0	0
MUC2	4583	broad.mit.edu	37	11	1102137	1102137	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:1102137G>A	uc001lsx.1	+	47	14886	c.14859G>A	c.(14857-14859)GTG>GTA	p.V4953V		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4953	VWFC 2.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CGGACAAGGTGGACAACAACA	0.617													21	22					0	0	0.002299	0	0
TNNI2	7136	broad.mit.edu	37	11	1862718	1862718	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:1862718G>A	uc010qxe.1	+	6	508	c.486G>A	c.(484-486)AGG>AGA	p.R162R	TNNI2_uc010qxc.1_Silent_p.R160R|TNNI2_uc010qxd.1_Silent_p.R160R	NM_001145841	NP_001139313	P48788	TNNI2_HUMAN	fast-twitch skeletal muscle troponin I isoform	162					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding				0		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GTGACTGGAGGAAGAACATCG	0.642													15	25					0	0	0.006122	0	0
OSBPL5	114879	broad.mit.edu	37	11	3125455	3125455	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:3125455G>A	uc001lxk.2	-	10	1370	c.1212C>T	c.(1210-1212)TCC>TCT	p.S404S	OSBPL5_uc010qxq.1_Silent_p.S315S|OSBPL5_uc009ydw.2_Silent_p.S336S|OSBPL5_uc001lxl.2_Silent_p.S336S|OSBPL5_uc009ydx.2_Silent_p.S428S	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	404					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		AGTAGTAGTCGGAGAGCTTGT	0.647													18	19					0	0	0.007413	0	0
TRIM21	6737	broad.mit.edu	37	11	4410955	4410955	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:4410955C>T	uc001lyy.1	-	3	546	c.433G>A	c.(433-435)GAA>AAA	p.E145K		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	145	Potential.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		CTTCTCAGTTCCCCTAATGCC	0.463													53	49					0	0	0.003610	0	0
OR51S1	119692	broad.mit.edu	37	11	4869588	4869588	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:4869588G>A	uc010qyo.1	-	1	851	c.851C>T	c.(850-852)TCC>TTC	p.S284F		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGGACATAGGATAGAAGAGT	0.448													22	40					0	0	0.003954	0	0
OR51B6	390058	broad.mit.edu	37	11	5373580	5373580	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:5373580C>T	uc010qzb.1	+	1	843	c.843C>T	c.(841-843)TTC>TTT	p.F281F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTTCCTTTTCCCACCTTTTA	0.383													26	50					0	0	0.003330	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5631789	5631789	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:5631789G>A	uc001mbf.2	+	7	1227	c.983G>A	c.(982-984)TGG>TAG	p.W328*	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_Nonsense_Mutation_p.W274*|TRIM6_uc010qzj.1_Nonsense_Mutation_p.W125*|TRIM6_uc001mbc.1_Nonsense_Mutation_p.W300*|TRIM6_uc001mbe.2_Nonsense_Mutation_p.W125*|TRIM6_uc010qzk.1_Nonsense_Mutation_p.W125*|TRIM6_uc010qzl.1_Nonsense_Mutation_p.W125*|TRIM6_uc001mbd.2_Nonsense_Mutation_p.W328*|TRIM6_uc001mbg.1_Nonsense_Mutation_p.W125*|TRIM6_uc009yep.1_Silent_p.L168L	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	328						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		CAAAGCTACTGGGGTAAGTAG	0.463													28	32					0	0	0.004289	0	0
OR52E4	390081	broad.mit.edu	37	11	5905976	5905976	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:5905976G>A	uc010qzs.1	+	1	454	c.454G>A	c.(454-456)GGA>AGA	p.G152R	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTGGTTGTTGGAAGAAATTT	0.463													30	49					0	0	0.008361	0	0
OR52B2	255725	broad.mit.edu	37	11	6191512	6191512	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:6191512G>A	uc010qzy.1	-	1	45	c.45C>T	c.(43-45)GTC>GTT	p.V15V		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCAGGAAGGACAAAAACTG	0.448													14	23					0	0	0.002450	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111152	7111152	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:7111152C>T	uc001mfc.2	+	1	988	c.801C>T	c.(799-801)GAC>GAT	p.D267D		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	267	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GAGGTCGCGACCGTGACTACG	0.667													7	14					0	0	0.003080	0	0
TUB	7275	broad.mit.edu	37	11	8118894	8118894	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:8118894C>T	uc001mga.2	+	7	956	c.807C>T	c.(805-807)ATC>ATT	p.I269I	TUB_uc010rbk.1_Silent_p.I275I|TUB_uc001mfy.2_Silent_p.I324I	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	269					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		AATGCCGCATCACTCGGGACA	0.577													28	47					0	0	0.002096	0	0
SCUBE2	57758	broad.mit.edu	37	11	9074719	9074719	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:9074719G>A	uc001mhh.1	-	12	1454	c.1374C>T	c.(1372-1374)TCC>TCT	p.S458S	SCUBE2_uc001mhi.1_Silent_p.S458S|SCUBE2_uc001mhj.1_Intron	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	458						extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		CGCAGTGCAGGGACACACGGG	0.552													11	22					0	0	0.000978	0	0
SCUBE2	57758	broad.mit.edu	37	11	9111275	9111275	+	Missense_Mutation	SNP	C	T	T	rs149203158		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:9111275C>T	uc001mhh.1	-	2	315	c.235G>A	c.(235-237)GGG>AGG	p.G79R	SCUBE2_uc001mhi.1_Missense_Mutation_p.G79R|SCUBE2_uc001mhj.1_Missense_Mutation_p.G79R	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	79	EGF-like 1; calcium-binding (Potential).					extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		CTGCCTTCCCCTTGGTAGCCA	0.577													42	41					0	0	0.002222	0	0
DENND5A	23258	broad.mit.edu	37	11	9164310	9164310	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:9164310G>A	uc001mhl.2	-	21	3725	c.3470C>T	c.(3469-3471)TCG>TTG	p.S1157L	DENND5A_uc001mhk.2_Missense_Mutation_p.S500L|DENND5A_uc010rbw.1_Missense_Mutation_p.S1157L	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	1157	RUN 2.									liver(1)	1						GAGCCGGGGCGATTTAAATCC	0.517													54	59					0	0	0.003610	0	0
EIF4G2	1982	broad.mit.edu	37	11	10824772	10824772	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:10824772G>A	uc001mjc.2	-	10	1300	c.883C>T	c.(883-885)CGT>TGT	p.R295C	EIF4G2_uc001mjb.2_Missense_Mutation_p.R89C|EIF4G2_uc009ygf.2_Missense_Mutation_p.R89C|EIF4G2_uc001mjd.2_Missense_Mutation_p.R295C|EIF4G2_uc001mjf.1_Missense_Mutation_p.R89C|SNORD97_uc009yge.2_5'Flank	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	295	MIF4G.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AGCAGGAAACGAATCCTTGCT	0.328													13	10					0	0	0.001855	0	0
DKK3	27122	broad.mit.edu	37	11	12023884	12023884	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:12023884C>T	uc001mju.2	-	2	371	c.314G>A	c.(313-315)GGA>GAA	p.G105E	DKK3_uc010rcf.1_Missense_Mutation_p.G105E|DKK3_uc001mjv.2_Missense_Mutation_p.G105E|DKK3_uc001mjw.2_Missense_Mutation_p.G105E|DKK3_uc010rcg.1_Missense_Mutation_p.G105E|DKK3_uc001mjx.2_Missense_Mutation_p.G105E	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	105					adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		GGTATTATTTCCAACCTTCGT	0.463													22	28					0	0	0.002299	0	0
MICAL2	9645	broad.mit.edu	37	11	12270730	12270730	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:12270730G>A	uc001mjz.2	+	22	3073	c.2785_splice	c.e22-1	p.E929_splice	MICAL2_uc010rch.1_Splice_Site_p.E739_splice|MICAL2_uc001mka.2_Splice_Site_p.E929_splice|MICAL2_uc010rci.1_Intron|MICAL2_uc001mkb.2_Splice_Site_p.E739_splice|MICAL2_uc001mkc.2_Intron|MICAL2_uc001mkd.2_Intron|MICAL2_uc010rcj.1_Splice_Site_p.E141_splice|MICAL2_uc001mkf.2_Intron	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin							cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TCTTTCTAAAGGAAaagaagt	0.189													11	30					0	0	0.001368	0	0
ABCC8	6833	broad.mit.edu	37	11	17418475	17418475	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:17418475G>A	uc001mnc.2	-	33	4233	c.4107C>T	c.(4105-4107)GCC>GCT	p.A1369A		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1369	Cytoplasmic (By similarity).|ABC transporter 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TCTGTCCAGGGGCGATGAGGG	0.617													95	113					0	0	0.003610	0	0
ABCC8	6833	broad.mit.edu	37	11	17436131	17436131	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:17436131G>A	uc001mnc.2	-	19	2444	c.2318C>T	c.(2317-2319)TCG>TTG	p.S773L		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	773	ABC transporter 1.|Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGGTTTCTGCGAAGCATAGGC	0.547													108	141					0	0	0.003610	0	0
LDHA	3939	broad.mit.edu	37	11	18421065	18421065	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:18421065C>T	uc001mok.3	+	3	486	c.214C>T	c.(214-216)CTT>TTT	p.L72F	LDHA_uc010rdc.1_Missense_Mutation_p.L72F|LDHA_uc009yhn.2_Missense_Mutation_p.L72F|LDHA_uc009yho.2_Intron|LDHA_uc001mol.3_Missense_Mutation_p.L72F|LDHA_uc010rdd.1_Missense_Mutation_p.L101F	NM_005566	NP_005557	P00338	LDHA_HUMAN	lactate dehydrogenase A isoform 1	72					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)	3					NADH(DB00157)	CAGCCTTTTCCTTAGAACACC	0.333													29	33					0	0	0.003271	0	0
SLC17A6	57084	broad.mit.edu	37	11	22397614	22397614	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:22397614G>A	uc001mqk.2	+	10	1674	c.1261G>A	c.(1261-1263)GGA>AGA	p.G421R		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	421	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						ACTTGCAGTGGGATTCAGTGG	0.398													58	88					0	0	0.003610	0	0
FANCF	2188	broad.mit.edu	37	11	22646373	22646373	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:22646373G>A	uc001mql.1	-	1	1015	c.984C>T	c.(982-984)GCC>GCT	p.A328A		NM_022725	NP_073562	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	328					DNA repair	nucleoplasm	protein binding			skin(1)	1						AGGTCTCCAGGGCAGTTAGAA	0.478			N|F			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia		OREG0020844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	59					0	0	0.002852	0	0
KCNA4	3739	broad.mit.edu	37	11	30032383	30032383	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:30032383C>T	uc001msk.2	-	2	2995	c.1843G>A	c.(1843-1845)GAA>AAA	p.E615K		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	615						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACTCCTTCTTCCATCTCTAGA	0.453													22	28					0	0	0.001523	0	0
Unknown	0	broad.mit.edu	37	11	30925117	30925117	+	RNA	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:30925117A>G	uc001mss.1	-	10		c.1525T>C			uc009yjk.1_Silent_p.D922D|uc009yjj.1_RNA					Homo sapiens mRNA for KIAA1493 protein, partial cds.																		GAAAGGATTCATCTAGAGCCC	0.433													6	9					0	0	0.001168	0	0
C11orf41	25758	broad.mit.edu	37	11	33564018	33564018	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:33564018C>T	uc001mup.3	+	1	142	c.18C>T	c.(16-18)TCC>TCT	p.S6S	C11orf41_uc001mun.1_Silent_p.S6S	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	6						integral to membrane				ovary(2)	2						ACACTGCATCCCAAAATGCCC	0.493													7	30					0	0	0.001984	0	0
FBXO3	26273	broad.mit.edu	37	11	33790420	33790420	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:33790420G>A	uc001muz.2	-	3	363	c.335C>T	c.(334-336)CCT>CTT	p.P112L	FBXO3_uc001muy.2_5'UTR|FBXO3_uc009ykb.2_RNA|FBXO3_uc001mva.1_Missense_Mutation_p.P112L|FBXO3_uc001mvb.1_Missense_Mutation_p.P107L|FBXO3_uc010rek.1_RNA	NM_012175	NP_036307	Q9UK99	FBX3_HUMAN	F-box only protein 3 isoform 1	112					proteolysis	nucleus	ubiquitin-protein ligase activity			pancreas(1)	1		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		AACCATCCGAGGACACCTGGG	0.388													37	145					0	0	0.004878	0	0
NAT10	55226	broad.mit.edu	37	11	34135386	34135386	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:34135386G>A	uc001mvk.2	+	5	739	c.495_splice	c.e5+1	p.M165_splice	NAT10_uc010ren.1_Splice_Site_p.M93_splice	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a							nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				AGTGACTATGGTAAGCATCTG	0.443													57	24					0	0	0.003610	0	0
PRDM11	56981	broad.mit.edu	37	11	45226312	45226312	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:45226312C>T	uc001myo.2	+	6	888	c.639C>T	c.(637-639)ACC>ACT	p.T213T		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	213	SET.									upper_aerodigestive_tract(1)	1						CAGACGAGACCAAAGCCAACT	0.542													25	37					0	0	0.001786	0	0
SLC35C1	55343	broad.mit.edu	37	11	45832552	45832552	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:45832552C>T	uc001nbp.2	+	2	1473	c.761C>T	c.(760-762)GCC>GTC	p.A254V	SLC35C1_uc001nbo.2_Missense_Mutation_p.A241V|SLC35C1_uc010rgm.1_Missense_Mutation_p.A241V	NM_018389	NP_060859	Q96A29	FUCT1_HUMAN	GDP-fucose transporter 1 isoform a	254						Golgi membrane|integral to membrane	GDP-fucose transmembrane transporter activity				0				GBM - Glioblastoma multiforme(35;0.227)		GAGCTTCAGGCCCTGCGTGAC	0.637													11	14					0	0	0.008291	0	0
HARBI1	283254	broad.mit.edu	37	11	46625266	46625266	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:46625266G>A	uc001ncy.2	-	3	1112	c.864C>T	c.(862-864)TCC>TCT	p.S288S		NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	288						cytoplasm|nucleus	metal ion binding|nuclease activity				0						TGATATGGCTGGATTTCTCTG	0.542													13	13					0	0	0.001368	0	0
HARBI1	283254	broad.mit.edu	37	11	46637407	46637408	+	Missense_Mutation	DNP	GG	AA	AA	rs141436294		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:46637407_46637408GG>AA	uc001ncy.2	-	2	628_629	c.380_381CC>TT	c.(379-381)TCC>TTT	p.S127F	KIAA0652_uc009yld.2_5'Flank|KIAA0652_uc001nda.2_5'Flank|KIAA0652_uc001ndb.2_5'Flank|KIAA0652_uc001ncz.2_5'Flank|KIAA0652_uc001ndc.2_5'Flank|KIAA0652_uc010rgv.1_5'Flank	NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	127						cytoplasm|nucleus	metal ion binding|nuclease activity				0						GAGCCTGAATGGAGGCTTCATC	0.52													48	84					0	0	0.004672	0	0
CKAP5	9793	broad.mit.edu	37	11	46784543	46784543	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:46784543G>A	uc001ndi.1	-	30	3984	c.3874C>T	c.(3874-3876)CCC>TCC	p.P1292S	CKAP5_uc009ylg.1_Missense_Mutation_p.P1178S|CKAP5_uc001ndj.1_Missense_Mutation_p.P1292S|CKAP5_uc001ndh.1_Missense_Mutation_p.P221S|SNORD67_uc001ndk.2_5'Flank	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1292	HEAT 8.				cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						ACAAGATAGGGGATGAAGGAA	0.403													18	34					0	0	0.008871	0	0
MYBPC3	4607	broad.mit.edu	37	11	47356689	47356689	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:47356689C>T	uc001nfa.3	-	26	2864	c.2809G>A	c.(2809-2811)GGG>AGG	p.G937R		NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	936	Fibronectin type-III 2.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		AGCCGGGCCCCCGTGGGCAGG	0.662													17	19					0	0	0.004990	0	0
FOLH1	2346	broad.mit.edu	37	11	49168382	49168382	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:49168382C>G	uc001ngy.2	-	19	2440	c.2179G>C	c.(2179-2181)GAA>CAA	p.E727Q	FOLH1_uc001ngx.2_Missense_Mutation_p.E126D|FOLH1_uc001ngz.2_Missense_Mutation_p.E696Q|FOLH1_uc009yly.2_Missense_Mutation_p.E712Q|FOLH1_uc009ylz.2_Missense_Mutation_p.E681Q|FOLH1_uc009yma.2_Missense_Mutation_p.E419Q	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	727	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	CTCTTCACTTCTCCCCAGGCC	0.463													32	41					0	0	0.008361	0	0
FOLH1	2346	broad.mit.edu	37	11	49229944	49229944	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:49229944G>A	uc001ngy.2	-	1	279	c.18C>T	c.(16-18)CAC>CAT	p.H6H	FOLH1_uc001ngz.2_Silent_p.H6H|FOLH1_uc009yly.2_Translation_Start_Site|FOLH1_uc009ylz.2_Translation_Start_Site|FOLH1_uc009yma.2_Translation_Start_Site|FOLH1_uc001nha.2_Translation_Start_Site	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	6	Cytoplasmic (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AGTCGGTTTCGTGAAGGAGAT	0.711													5	9					0	0	0.004482	0	0
TRIM48	79097	broad.mit.edu	37	11	55036761	55036761	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55036761G>A	uc010rid.1	+	5	708	c.622G>A	c.(622-624)GCG>ACG	p.A208T		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	192						intracellular	zinc ion binding				0						TCTGAATCTAGCGCTCAGGGC	0.493													22	22					0	0	0.005443	0	0
OR5L1	219437	broad.mit.edu	37	11	55578978	55578978	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55578978C>T	uc001nhw.1	+	1	36	c.36C>T	c.(34-36)TTC>TTT	p.F12F		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TGGCTGAGTTCATTCTCCTTG	0.423													55	250					0	0	0.003610	0	0
OR5F1	338674	broad.mit.edu	37	11	55761646	55761646	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55761646C>T	uc010riv.1	-	1	456	c.456G>A	c.(454-456)GGG>GGA	p.G152G		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					AGTTCAGCAACCCTGCAGCAA	0.507													23	77					0	0	0.002780	0	0
OR8H2	390151	broad.mit.edu	37	11	55872764	55872764	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55872764C>T	uc010riy.1	+	1	246	c.246C>T	c.(244-246)ACC>ACT	p.T82T		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CACCTAAAACCTTAGCGAACT	0.433										HNSCC(53;0.14)			76	478					0	0	0.003610	0	0
OR8H3	390152	broad.mit.edu	37	11	55890068	55890068	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55890068T>A	uc001nii.1	+	1	220	c.220T>A	c.(220-222)TAC>AAC	p.Y74N		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TGACCTCAGTTACTCAACTGT	0.448													89	463					0	0	0.003610	0	0
OR8H3	390152	broad.mit.edu	37	11	55890640	55890640	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55890640G>A	uc001nii.1	+	1	792	c.792G>A	c.(790-792)AAG>AAA	p.K264K		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					AGCCAAGAAAGTCTTATTCCT	0.388													22	200					0	0	0.001523	0	0
OR8J1	219477	broad.mit.edu	37	11	56128611	56128611	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:56128611G>A	uc010rjh.1	+	1	889	c.889G>A	c.(889-891)GAT>AAT	p.D297N		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAGGAATAAGGATGTGAAGAC	0.363													19	153					0	0	0.001523	0	0
OR8J1	219477	broad.mit.edu	37	11	56128658	56128658	+	Silent	SNP	C	T	T	rs148720229		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:56128658C>T	uc010rjh.1	+	1	936	c.936C>T	c.(934-936)TCC>TCT	p.S312S		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGTGCTATTCCTTTAAAACAA	0.353													12	105					0	0	0.000978	0	0
OR5M3	219482	broad.mit.edu	37	11	56237335	56237335	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:56237335G>A	uc010rjk.1	-	1	639	c.639C>T	c.(637-639)ATC>ATT	p.I213I		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AGTAAGAGATGATAATTACAG	0.443													15	156					0	0	0.004007	0	0
OR5M11	219487	broad.mit.edu	37	11	56310479	56310479	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:56310479G>A	uc010rjl.1	-	1	255	c.255C>T	c.(253-255)ATC>ATT	p.I85I		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTCAGATACGATATTAGTCG	0.448													28	359					0	0	0.005443	0	0
OR5M10	390167	broad.mit.edu	37	11	56345099	56345099	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:56345099C>T	uc001niz.1	-	1	99	c.99G>A	c.(97-99)GCG>GCA	p.A33A		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTAGGTAGATCGCCAGGAACA	0.488													106	372					0	0	0.003610	0	0
APLNR	187	broad.mit.edu	37	11	57003372	57003372	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57003372G>A	uc001njo.2	-	1	1556	c.1107C>T	c.(1105-1107)TCC>TCT	p.S369S	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	369	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						TGTAGGGGATGGATTTCTCGT	0.627													14	58					0	0	0.004007	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57077309	57077309	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57077309C>T	uc001njr.2	-	5	3188	c.2876G>A	c.(2875-2877)AGG>AAG	p.R959K	TNKS1BP1_uc001njs.2_Missense_Mutation_p.R959K|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.R410K	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	959	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				GCTGTAGTCCCTTATCCAAGC	0.602													98	114					0	0	0.003610	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57080341	57080341	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57080341G>A	uc001njr.2	-	4	2133	c.1821C>T	c.(1819-1821)ACC>ACT	p.T607T	TNKS1BP1_uc001njs.2_Silent_p.T607T|TNKS1BP1_uc009ymd.1_Silent_p.T58T	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	607	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				CTGCCTCCCTGGTAGCCAGGG	0.637													20	65					0	0	0.002780	0	0
P2RX3	5024	broad.mit.edu	37	11	57137411	57137411	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57137411G>A	uc001nju.2	+	12	1211	c.1135G>A	c.(1135-1137)GAC>AAC	p.D379N		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	379	Cytoplasmic (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GTACCCCAGCGACCAGACCAC	0.577													8	43					0	0	0.000978	0	0
SERPING1	710	broad.mit.edu	37	11	57367838	57367838	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57367838C>T	uc001nkp.1	+	3	729	c.538C>T	c.(538-540)CAG>TAG	p.Q180*	SERPING1_uc001nkq.1_Nonsense_Mutation_p.Q180*|SERPING1_uc010rju.1_Nonsense_Mutation_p.Q128*|SERPING1_uc010rjv.1_Nonsense_Mutation_p.Q185*|SERPING1_uc001nkr.1_Nonsense_Mutation_p.Q180*|SERPING1_uc009ymi.1_Nonsense_Mutation_p.Q180*|SERPING1_uc009ymj.1_Nonsense_Mutation_p.Q180*|SERPING1_uc001nks.1_Intron	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	180					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						CCTCCTTACCCAGGTCCTGCT	0.512									Hereditary_Angioedema				30	90					0	0	0.002445	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799105	57799105	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57799105G>A	uc010rjz.1	+	1	681	c.681G>A	c.(679-681)TGG>TGA	p.W227*	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				ACATCGTCTGGACACTGCTGC	0.542													53	53					0	0	0.003610	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799156	57799156	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57799156C>T	uc010rjz.1	+	1	732	c.732C>T	c.(730-732)ACC>ACT	p.T244T	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				CCTTCTCTACCTGTGCAGCTC	0.527													42	129					0	0	0.002852	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947001	57947001	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57947001C>T	uc001nmj.2	+	3	401	c.85C>T	c.(85-87)CTC>TTC	p.L29F		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				CCCTCTCTTCCTCTTGTTTTT	0.453													45	154					0	0	0.008740	0	0
OR1S2	219958	broad.mit.edu	37	11	57970829	57970829	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57970829G>A	uc010rkb.1	-	1	825	c.825C>T	c.(823-825)CCC>CCT	p.P275P		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	275	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				GAGTGGAGGAGGGGAAAAAGT	0.493													51	48					0	0	0.003610	0	0
DTX4	23220	broad.mit.edu	37	11	58962828	58962828	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:58962828C>T	uc001nns.2	+	7	1779	c.1522C>T	c.(1522-1524)CCC>TCC	p.P508S	DTX4_uc001nnr.2_Missense_Mutation_p.P402S	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	508					Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				CTACAGCATCCCCCCCGGCAT	0.512													8	31					0	0	0.003080	0	0
MPEG1	219972	broad.mit.edu	37	11	58978379	58978379	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:58978379C>T	uc001nnu.3	-	1	2116	c.1960G>A	c.(1960-1962)GGA>AGA	p.G654R		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	654	Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				GCAGCCCCTCCTGACAGACCA	0.567													37	72					0	0	0.008740	0	0
MS4A6A	64231	broad.mit.edu	37	11	59949119	59949119	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:59949119C>T	uc001nor.2	-	2	320	c.82G>A	c.(82-84)GAA>AAA	p.E28K	MS4A6A_uc001noq.2_Missense_Mutation_p.E28K|MS4A6A_uc001nos.3_Missense_Mutation_p.E56K|MS4A6A_uc009ymv.2_Missense_Mutation_p.E28K|MS4A6A_uc001not.2_Missense_Mutation_p.E28K|MS4A6A_uc010rla.1_Missense_Mutation_p.E56K|MS4A6A_uc010rlb.1_Missense_Mutation_p.E28K	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	28	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						TTGGTGGGTTCGGGTTTCTCT	0.463													40	59					0	0	0.002522	0	0
PRPF19	27339	broad.mit.edu	37	11	60668840	60668840	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:60668840C>T	uc001nqf.2	-	8	776	c.569G>A	c.(568-570)AGA>AAA	p.R190K		NM_014502	NP_055317	Q9UMS4	PRP19_HUMAN	PRP19/PSO4 pre-mRNA processing factor 19	190					DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						AGTCTTCCCTCTCTGAGAAAA	0.557													12	15					0	0	0.000978	0	0
VWCE	220001	broad.mit.edu	37	11	61042021	61042021	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:61042021C>T	uc001nra.2	-	12	1810	c.1531G>A	c.(1531-1533)GGG>AGG	p.G511R	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	511	VWFC 3.					extracellular region	calcium ion binding			ovary(1)	1						AACACAGCCCCGTCTGCGTAC	0.572													14	13					0	0	0.004990	0	0
VWCE	220001	broad.mit.edu	37	11	61048115	61048115	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:61048115C>T	uc001nra.2	-	9	1584	c.1305G>A	c.(1303-1305)GGG>GGA	p.G435G	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	435	VWFC 1.					extracellular region	calcium ion binding			ovary(1)	1						ATGGGCAGCACCCACCATCTC	0.542													12	19					0	0	0.004007	0	0
C11orf66	220004	broad.mit.edu	37	11	61250166	61250166	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:61250166G>A	uc001nru.1	+	4	392	c.267G>A	c.(265-267)CAG>CAA	p.Q89Q	C11orf66_uc009ynq.1_Silent_p.Q89Q	NM_145017	NP_659454	Q7Z5V6	CK066_HUMAN	IIIG9 protein	89										ovary(1)	1						TGGCCAGCCAGAGCTACCGCC	0.652											OREG0021002	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	17					0	0	0.006122	0	0
ASRGL1	80150	broad.mit.edu	37	11	62159581	62159581	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62159581C>T	uc001nte.3	+	7	1036	c.752C>T	c.(751-753)TCG>TTG	p.S251L	ASRGL1_uc001ntf.3_Missense_Mutation_p.S251L|ASRGL1_uc001ntg.3_Missense_Mutation_p.S123L	NM_025080	NP_079356	Q7L266	ASGL1_HUMAN	asparaginase-like 1	251					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	GCGGACCTATCGTTGGGTTAT	0.478											OREG0021023	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	43					0	0	0.005443	0	0
AHNAK	79026	broad.mit.edu	37	11	62295771	62295771	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62295771G>A	uc001ntl.2	-	5	6418	c.6118C>T	c.(6118-6120)CAT>TAT	p.H2040Y	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2040					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCTGGGCCATGAACATCCACA	0.498													111	171					0	0	0.003610	0	0
AHNAK	79026	broad.mit.edu	37	11	62296260	62296260	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62296260C>T	uc001ntl.2	-	5	5929	c.5629G>A	c.(5629-5631)GTG>ATG	p.V1877M	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1877					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AATTTTGGCACCGACACATCC	0.517													57	80					0	0	0.003610	0	0
ROM1	6094	broad.mit.edu	37	11	62382274	62382274	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62382274G>A	uc001ntv.2	+	3	1560	c.1019G>A	c.(1018-1020)GGA>GAA	p.G340E	EML3_uc001ntt.1_5'Flank|EML3_uc001ntu.1_5'Flank|EML3_uc010rly.1_5'Flank	NM_000327	NP_000318	Q03395	ROM1_HUMAN	retinal outer segment membrane protein 1	340	Cytoplasmic (Potential).				cell adhesion|visual perception	integral to plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GCCCCACCAGGAGAAGCACCT	0.572													12	20					0	0	0.003163	0	0
LRRN4CL	221091	broad.mit.edu	37	11	62455825	62455825	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62455825G>A	uc001nun.2	-	2	463	c.156C>T	c.(154-156)CAC>CAT	p.H52H		NM_203422	NP_981967	Q8ND94	LRN4L_HUMAN	LRRN4 C-terminal like precursor	52	Extracellular (Potential).					integral to membrane					0						GGTGTCGGCAGTGGTCGTAGT	0.687													8	18					0	0	0.004482	0	0
SLC22A25	387601	broad.mit.edu	37	11	62951205	62951205	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62951205C>T	uc001nwr.1	-	5	915	c.915G>A	c.(913-915)AGG>AGA	p.R305R	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA|SLC22A25_uc001nwt.1_Silent_p.R305R	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	305	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						TCATTCCATTCCTGTGTGCAG	0.463													72	83					0	0	0.003610	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64132833	64132833	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:64132833C>T	uc001oae.2	+	9	1050	c.967C>T	c.(967-969)CGC>TGC	p.R323C	RPS6KA4_uc001oad.2_Missense_Mutation_p.R323C|RPS6KA4_uc010rnl.1_Missense_Mutation_p.R260C|RPS6KA4_uc001oaf.2_Missense_Mutation_p.R323C|RPS6KA4_uc009ypp.2_Missense_Mutation_p.R323C	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	323	AGC-kinase C-terminal.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						GCCCCAAATCCGCTCAGAGCT	0.622													15	23					0	0	0.003163	0	0
SLC22A11	55867	broad.mit.edu	37	11	64337277	64337277	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:64337277C>T	uc001oai.2	+	9	1910	c.1536C>T	c.(1534-1536)CTC>CTT	p.L512L	SLC22A11_uc001oaj.2_Intron|SLC22A11_uc009ypq.2_Silent_p.L404L	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	512	Cytoplasmic (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	TGTTCTTCCTCCCGGAGACCC	0.622													31	7					0	0	0.002445	0	0
NPAS4	266743	broad.mit.edu	37	11	66191616	66191616	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:66191616G>A	uc001ohx.1	+	7	1431	c.1255G>A	c.(1255-1257)GAT>AAT	p.D419N	NPAS4_uc010rpc.1_Missense_Mutation_p.D209N	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	419					transcription, DNA-dependent		DNA binding|signal transducer activity				0						ACTAAGCAAGGATCTTGTGTG	0.557													47	55					0	0	0.003610	0	0
BBS1	582	broad.mit.edu	37	11	66298428	66298428	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:66298428C>T	uc001oij.1	+	15	1549	c.1537C>T	c.(1537-1539)CCT>TCT	p.P513S	BBS1_uc001oii.1_Missense_Mutation_p.P550S|BBS1_uc010rpg.1_Missense_Mutation_p.P416S|BBS1_uc001oik.1_Missense_Mutation_p.P437S|BBS1_uc001oil.1_Missense_Mutation_p.P384S|ZDHHC24_uc001oim.1_Intron|ZDHHC24_uc009yrg.1_Intron|BBS1_uc010rph.1_Missense_Mutation_p.P181S	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	513					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						AACAACCCGTCCTGTCCTGGG	0.567									Bardet-Biedl_syndrome				22	54					0	0	0.002299	0	0
PC	5091	broad.mit.edu	37	11	66617702	66617702	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:66617702C>T	uc001ojn.1	-	17	2756	c.2707G>A	c.(2707-2709)GAT>AAT	p.D903N	PC_uc001ojo.1_Missense_Mutation_p.D903N|PC_uc001ojp.1_Missense_Mutation_p.D903N|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	903					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	TTGATGAGATCGCCCAGCATC	0.617													21	41					0	0	0.002299	0	0
CABP2	51475	broad.mit.edu	37	11	67287268	67287268	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:67287268G>A	uc001omc.1	-	6	735	c.633C>T	c.(631-633)TTC>TTT	p.F211F	CABP2_uc001omd.1_Silent_p.F154F|CABP2_uc001ome.1_Silent_p.F217F	NM_016366	NP_057450	Q9NPB3	CABP2_HUMAN	calcium binding protein 2 isoform 1	211	EF-hand 4.|3 (Potential).				signal transduction	Golgi apparatus|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1						GGGTACCTTCGAAGTCGACCA	0.577													45	70					0	0	0.003610	0	0
GSTP1	2950	broad.mit.edu	37	11	67353865	67353865	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:67353865C>T	uc001omf.2	+	7	699	c.450C>T	c.(448-450)TCC>TCT	p.S150S	GSTP1_uc001omg.1_Silent_p.S131S	NM_000852	NP_000843	P09211	GSTP1_HUMAN	glutathione transferase	150	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			ovary(1)	1					Ethacrynic acid(DB00903)|Glutathione(DB00143)	TGCAGATCTCCTTCGCTGACT	0.642													15	57					0	0	0.004990	0	0
GSTP1	2950	broad.mit.edu	37	11	67353922	67353922	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:67353922C>T	uc001omf.2	+	7	756	c.507C>T	c.(505-507)GGC>GGT	p.G169G	GSTP1_uc001omg.1_Silent_p.G150G	NM_000852	NP_000843	P09211	GSTP1_HUMAN	glutathione transferase	169	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			ovary(1)	1					Ethacrynic acid(DB00903)|Glutathione(DB00143)	TAGCCCCTGGCTGCCTGGATG	0.647													19	62					0	0	0.002299	0	0
LRP5	4041	broad.mit.edu	37	11	68115509	68115509	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:68115509G>A	uc001ont.2	+	2	361	c.286G>A	c.(286-288)GGG>AGG	p.G96R	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	96	Beta-propeller 1.|LDL-receptor class B 1.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GAACCAGACGGGGGCCGCCGT	0.637													73	91					0	0	0.003610	0	0
LRP5	4041	broad.mit.edu	37	11	68153959	68153959	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:68153959C>T	uc001ont.2	+	6	1266	c.1191C>T	c.(1189-1191)ATC>ATT	p.I397I	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	397	LDL-receptor class B 6.|Beta-propeller 2.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						TGCGGGCCATCCGCAGGGCGT	0.637													13	52					0	0	0.001855	0	0
CPT1A	1374	broad.mit.edu	37	11	68529011	68529011	+	Missense_Mutation	SNP	G	A	A	rs75908421		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:68529011G>A	uc001oog.3	-	16	2190	c.2020C>T	c.(2020-2022)CTT>TTT	p.L674F	CPT1A_uc001oof.3_Missense_Mutation_p.L674F|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	674	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	ACTTCCTTAAGGAAAGGGGAC	0.448													94	46					0	0	0.003610	0	0
SHANK2	22941	broad.mit.edu	37	11	70333095	70333095	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:70333095G>A	uc001oqc.2	-	21	3381	c.3303C>T	c.(3301-3303)GCC>GCT	p.A1101A	SHANK2_uc010rqn.1_Silent_p.A513A|SHANK2_uc001opz.2_Silent_p.A506A|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	722					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGGAGAGGAAGGCCGGGGAGT	0.692													13	202					0	0	0.002450	0	0
SHANK2	22941	broad.mit.edu	37	11	70333519	70333519	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:70333519G>A	uc001oqc.2	-	21	2957	c.2879C>T	c.(2878-2880)TCC>TTC	p.S960F	SHANK2_uc010rqn.1_Missense_Mutation_p.S372F|SHANK2_uc001opz.2_Missense_Mutation_p.S365F|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	581					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			AGAGTCCAAGGAGTAGCGGTC	0.592													17	219					0	0	0.004990	0	0
SHANK2	22941	broad.mit.edu	37	11	70336491	70336491	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:70336491G>A	uc001oqc.2	-	19	2519	c.2441C>T	c.(2440-2442)TCT>TTT	p.S814F	SHANK2_uc010rqn.1_Missense_Mutation_p.S226F|SHANK2_uc001opz.2_Missense_Mutation_p.S219F|uc009ysn.1_Intron|SHANK2_uc010rqp.1_Missense_Mutation_p.S216F|SHANK2_uc001opy.2_5'UTR|SHANK2_uc010rqo.1_Missense_Mutation_p.S27F	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	435					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTCGTACACAGACTGCAAACC	0.622													26	271					0	0	0.008361	0	0
ARAP1	116985	broad.mit.edu	37	11	72406094	72406094	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:72406094G>A	uc001osu.2	-	27	3814	c.3625C>T	c.(3625-3627)CGC>TGC	p.R1209C	ARAP1_uc001osv.2_Missense_Mutation_p.R1209C|ARAP1_uc001osr.2_Missense_Mutation_p.R969C|ARAP1_uc001oss.2_Missense_Mutation_p.R964C|ARAP1_uc009yth.2_Missense_Mutation_p.R903C|ARAP1_uc010rre.1_Missense_Mutation_p.R964C	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1209	Ras-associating.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						ACGTTCCGGCGATCCAGGATC	0.612													98	63					0	0	0.003610	0	0
UCP2	7351	broad.mit.edu	37	11	73686070	73686070	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:73686070G>A	uc001oup.1	-	8	1292	c.912C>T	c.(910-912)TCC>TCT	p.S304S	UCP2_uc001ouq.1_3'UTR	NM_003355	NP_003346	P55851	UCP2_HUMAN	uncoupling protein 2	304					proton transport|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding				0	Breast(11;0.000112)					GAGCCTCTCGGGAAGTGCAGG	0.517													6	7					0	0	0.001984	0	0
DGAT2	84649	broad.mit.edu	37	11	75501774	75501774	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:75501774C>T	uc001oxa.2	+	4	686	c.427C>T	c.(427-429)CAG>TAG	p.Q143*	DGAT2_uc001oxb.2_Nonsense_Mutation_p.Q100*	NM_032564	NP_115953	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	143	Cytoplasmic (Potential).				glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity				0	Ovarian(111;0.103)					CTTTCCCATCCAGGTAAAGTG	0.517													18	66					0	0	0.001523	0	0
DGAT2	84649	broad.mit.edu	37	11	75509329	75509329	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:75509329C>G	uc001oxa.2	+	7	1126	c.867C>G	c.(865-867)ATC>ATG	p.I289M	DGAT2_uc001oxb.2_Missense_Mutation_p.I246M	NM_032564	NP_115953	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	289	Cytoplasmic (Potential).				glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity				0	Ovarian(111;0.103)					AGCAGGTGATCTTCGAGGAGG	0.547													40	145					0	0	0.002522	0	0
MYO7A	4647	broad.mit.edu	37	11	76885807	76885807	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:76885807C>T	uc001oyb.2	+	17	2213	c.1941C>T	c.(1939-1941)TTC>TTT	p.F647F	MYO7A_uc010rsl.1_Silent_p.F647F|MYO7A_uc010rsm.1_Silent_p.F636F|MYO7A_uc001oyc.2_Silent_p.F647F|MYO7A_uc001oyd.2_5'UTR	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	647	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GGCAGCTGTTCGACCGGCACC	0.617													6	3					0	0	0.003080	0	0
HEPHL1	341208	broad.mit.edu	37	11	93797567	93797567	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:93797567G>A	uc001pep.2	+	4	856	c.699G>A	c.(697-699)GTG>GTA	p.V233V		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	233	Plastocyanin-like 2.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TTACTCTTGTGGATGAGAATC	0.393													21	18					0	0	0.001882	0	0
CNTN5	53942	broad.mit.edu	37	11	100170010	100170010	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:100170010C>T	uc001pga.2	+	20	2841	c.2502C>T	c.(2500-2502)TTC>TTT	p.F834F	CNTN5_uc001pfz.2_Silent_p.F834F|CNTN5_uc001pgb.2_Silent_p.F760F|CNTN5_uc010ruk.1_Silent_p.F105F	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	834	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTTCCAAATTCATTTATCGAG	0.428													36	3					0	0	0.004878	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103194685	103194685	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:103194685C>T	uc001pho.2	+	82	12150	c.12006C>T	c.(12004-12006)ATC>ATT	p.I4002I	DYNC2H1_uc001phn.1_Silent_p.I4009I|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	4002					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CTGCCAATATCGCTCGCTCAT	0.388													23	7					0	0	0.004656	0	0
DDI1	414301	broad.mit.edu	37	11	103907797	103907797	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:103907797C>T	uc001phr.2	+	1	490	c.247C>T	c.(247-249)CGG>TGG	p.R83W	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	83					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TGTGGGACCTCGGGCTCCAGG	0.612													45	70					0	0	0.003610	0	0
NCAM1	4684	broad.mit.edu	37	11	113130934	113130934	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:113130934C>T	uc001pns.2	+	2	192	c.160C>T	c.(160-162)CTG>TTG	p.L54L				P13591	NCAM1_HUMAN	SubName: Full=cDNA FLJ52974, highly similar to Neural cell adhesion molecule 1, 140 kDa isoform;	674	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GCTGAAGTCCCTGGACTGGAA	0.557													12	32					0	0	0.000978	0	0
DSCAML1	57453	broad.mit.edu	37	11	117329477	117329477	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:117329477C>T	uc001prh.1	-	19	3743	c.3741G>A	c.(3739-3741)AAG>AAA	p.K1247K		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1187	Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CACCGTCCTCCTTGGTCTGGA	0.647													7	7					0	0	0.003080	0	0
IL10RA	3587	broad.mit.edu	37	11	117864127	117864127	+	Splice_Site	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:117864127T>A	uc001prv.2	+	4	614	c.537_splice	c.e4+2	p.T179_splice	IL10RA_uc010rxl.1_Splice_Site_p.T159_splice|IL10RA_uc010rxm.1_Splice_Site_p.T159_splice|IL10RA_uc010rxn.1_Splice_Site_p.T30_splice|IL10RA_uc001prw.2_Splice_Site_p.T30_splice	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor							integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		AACTTCACGGTATGGGGTTCC	0.557													25	7					0	0	0.004656	0	0
PDZD3	79849	broad.mit.edu	37	11	119059864	119059864	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:119059864G>A	uc001pwb.2	+	8	2160	c.1636G>A	c.(1636-1638)GCC>ACC	p.A546T	PDZD3_uc001pvy.2_Missense_Mutation_p.A466T|PDZD3_uc001pvz.2_Missense_Mutation_p.A480T|PDZD3_uc010rzd.1_Missense_Mutation_p.A467T|PDZD3_uc001pwa.2_Missense_Mutation_p.A176T			Q86UT5	NHRF4_HUMAN	RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF4;          Short=NHERF-4; AltName: Full=PDZ domain-containing protein 3; AltName: Full=PDZ domain-containing protein 2; AltName: Full=Intestinal and kidney-enriched PDZ protein; AltName: Full=Sodium-hydrogen exchanger regulatory factor 4;	546	PDZ 4.				cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)	1	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		GAAGCTGGCAGCCAGGTCTCT	0.597													7	9					0	0	0.001984	0	0
TECTA	7007	broad.mit.edu	37	11	120998869	120998869	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:120998869C>T	uc010rzo.1	+	8	2183	c.2183C>T	c.(2182-2184)TCC>TTC	p.S728F		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	728	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GACGGCGCCTCCTACGCCTTC	0.617													32	30					0	0	0.004289	0	0
SC5DL	6309	broad.mit.edu	37	11	121178097	121178097	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:121178097C>T	uc001pxu.2	+	5	924	c.776C>T	c.(775-777)TCC>TTC	p.S259F	SC5DL_uc001pxt.2_3'UTR|SC5DL_uc001pxv.2_Missense_Mutation_p.S259F	NM_006918	NP_008849	O75845	SC5D_HUMAN	sterol-C5-desaturase	259				PQILQPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKN PSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTK TE -> RMKNYSMESLQRLNRLLPSYS (in Ref. 1; BAA18970).	fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	C-5 sterol desaturase activity|iron ion binding|lathosterol oxidase activity			ovary(1)	1		Breast(109;0.00328)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)	OV - Ovarian serous cystadenocarcinoma(1;0.0334)	BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		AATCCTTCATCCTTTGAGGGG	0.413													29	35					0	0	0.002445	0	0
C11orf63	79864	broad.mit.edu	37	11	122817290	122817290	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:122817290A>G	uc001pym.2	+	6	2016	c.1719A>G	c.(1717-1719)CAA>CAG	p.Q573Q		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	573										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AGCATCAGCAAGCCTTGGTGC	0.488													27	2					0	0	0.003954	0	0
TMEM225	338661	broad.mit.edu	37	11	123753985	123753985	+	Missense_Mutation	SNP	C	T	T	rs77654932	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:123753985C>T	uc001pzi.2	-	4	746	c.538G>A	c.(538-540)GAA>AAA	p.E180K		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	180						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						TCCTTACATTCGTTGTCAGAT	0.443													33	4					0	0	0.003755	0	0
OR8G2	26492	broad.mit.edu	37	11	124095545	124095545	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:124095545G>A	uc010saf.1	+	1	148	c.148G>A	c.(148-150)GTC>ATC	p.V50I		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	50						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AATCTATGTGGTCACAGTGGT	0.507													37	55					0	0	0.006999	0	0
OR8B8	26493	broad.mit.edu	37	11	124310103	124310103	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:124310103C>T	uc010sal.1	-	1	879	c.879G>A	c.(877-879)AGG>AGA	p.R293R		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		CGTCCTTATTCCTCAGGCTAT	0.408													19	22					0	0	0.008871	0	0
OR8A1	390275	broad.mit.edu	37	11	124440145	124440146	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:124440145_124440146GG>AA	uc010san.1	+	1	181_182	c.181_182GG>AA	c.(181-183)GGC>AAC	p.G61N		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	61	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GGGGAACCTGGGCATGATCACT	0.5													21	43					0	0	0.004672	0	0
EI24	9538	broad.mit.edu	37	11	125448110	125448111	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:125448110_125448111CC>TT	uc001qca.2	+	6	640_641	c.398_399CC>TT	c.(397-399)CCC>CTT	p.P133L	EI24_uc001qcb.2_Missense_Mutation_p.P133L|EI24_uc010sbd.1_RNA|EI24_uc009zbl.2_Missense_Mutation_p.P133L|EI24_uc001qcc.2_RNA|EI24_uc010sbe.1_Missense_Mutation_p.P119L|EI24_uc010sbf.1_RNA	NM_004879	NP_004870	O14681	EI24_HUMAN	etoposide induced 2.4 isoform 1	133	Helical; (Potential).				apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		TGGGTGCTCCCCTTGTTTGTGC	0.5													46	59					0	0	0.004672	0	0
CDON	50937	broad.mit.edu	37	11	125859626	125859626	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:125859626G>A	uc009zbw.2	-	15	2807	c.2679C>T	c.(2677-2679)CAC>CAT	p.H893H	CDON_uc001qdb.3_Silent_p.H270H|CDON_uc001qdc.3_Silent_p.H893H	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	893	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CTGGCTGCAGGTGGCCAATCA	0.368													30	5					0	0	0.006320	0	0
WNK1	65125	broad.mit.edu	37	12	994852	994853	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:994852_994853CC>TT	uc001qio.3	+	19	5389_5390	c.4882_4883CC>TT	c.(4882-4884)CCC>TTC	p.P1628F	WNK1_uc001qip.3_Missense_Mutation_p.P1381F|WNK1_uc001qir.3_Missense_Mutation_p.P801F	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1628					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			AGCTTTGCTTCCCAACCAGCCC	0.475													24	51					0	0	0.004672	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1904487	1904487	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:1904487G>A	uc001qjp.2	-	37	3518	c.3287C>T	c.(3286-3288)TCC>TTC	p.S1096F	CACNA2D4_uc001qjo.2_Missense_Mutation_p.P241S	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	1096	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GGCGTGGCAGGAGTCTGGTCG	0.592													10	21					0	0	0.001368	0	0
NRIP2	83714	broad.mit.edu	37	12	2936809	2936809	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:2936809C>T	uc001qlc.2	-	5	807	c.735G>A	c.(733-735)CAG>CAA	p.Q245Q	ITFG2_uc010sec.1_Intron|NRIP2_uc010sed.1_Silent_p.Q245Q	NM_031474	NP_113662	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	245	LXXLL motif.				proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			AAAGCAGAGTCTGCAGGCCCA	0.522													63	113					0	0	0.003610	0	0
KCNA5	3741	broad.mit.edu	37	12	5154975	5154975	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:5154975G>A	uc001qni.2	+	1	1891	c.1662G>A	c.(1660-1662)CGG>CGA	p.R554R		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	554						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						GAGTCCAGCGGAAGGTCAGCG	0.637													7	19					0	0	0.001984	0	0
C1R	715	broad.mit.edu	37	12	7242783	7242783	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:7242783T>C	uc010sfy.1	-	3	352	c.293A>G	c.(292-294)AAC>AGC	p.N98S	C1R_uc010sfz.1_Missense_Mutation_p.N112S|C1R_uc010sga.1_Intron	NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	98	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCCCGGGGGGTTGCCCAGTGG	0.517													3	6					0	0	0.000248	0	0
CD163	9332	broad.mit.edu	37	12	7637816	7637816	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:7637816G>A	uc001qsz.3	-	11	2783	c.2655C>T	c.(2653-2655)TCC>TCT	p.S885S	CD163_uc001qta.3_Silent_p.S885S|CD163_uc009zfw.2_Silent_p.S918S	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	885	SRCR 8.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						ACATGGGAATGGACATGGCCT	0.547													21	35					0	0	0.001523	0	0
CD163	9332	broad.mit.edu	37	12	7653749	7653749	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:7653749C>T	uc001qsz.3	-	3	571	c.443G>A	c.(442-444)GGA>GAA	p.G148E	CD163_uc001qta.3_Missense_Mutation_p.G148E|CD163_uc009zfw.2_Missense_Mutation_p.G148E	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	148	SRCR 1.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GCAGGTCACTCCAGCATCTTG	0.423													56	105					0	0	0.003610	0	0
C12orf59	120939	broad.mit.edu	37	12	10339122	10339122	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:10339122C>T	uc001qxr.2	+	4	858	c.241C>T	c.(241-243)CCA>TCA	p.P81S	C12orf59_uc001qxq.2_Missense_Mutation_p.P61S			Q4KMG9	CL059_HUMAN	RecName: Full=Uncharacterized protein C12orf59; Flags: Precursor;	81						integral to membrane				ovary(1)	1						AGATGGGGGCCCACCACCCTG	0.562													29	38					0	0	0.006320	0	0
KLRC3	3823	broad.mit.edu	37	12	10587971	10587971	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:10587971G>A	uc001qyh.2	-	2	233	c.226C>T	c.(226-228)CTA>TTA	p.L76L	KLRC2_uc010she.1_Silent_p.L76L|KLRC2_uc001qyk.2_Silent_p.L76L	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	76	Helical; Signal-anchor for type II membrane protein; (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						ATGATTCCTAGGACCTCGGCA	0.423													44	77					0	0	0.003610	0	0
TAS2R7	50837	broad.mit.edu	37	12	10954787	10954787	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:10954787C>T	uc001qyv.2	-	1	440	c.383G>A	c.(382-384)AGG>AAG	p.R128K		NM_023919	NP_076408	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	128	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						GGAAATCACCCTGTCAATTCT	0.423													12	10					0	0	0.001855	0	0
PRB3	5544	broad.mit.edu	37	12	11420678	11420678	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:11420678C>T	uc001qzs.2	-	3	543	c.505G>A	c.(505-507)GGA>AGA	p.G169R	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	169	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.|6.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TGGTTTCCTCCTTGTGGGGGT	0.652													44	74					0	0	0.003610	0	0
BCL2L14	79370	broad.mit.edu	37	12	12247624	12247624	+	Silent	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:12247624C>A	uc001rac.2	+	5	906	c.705C>A	c.(703-705)GGC>GGA	p.G235G	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_Intron|BCL2L14_uc001rad.2_Silent_p.G235G|BCL2L14_uc001rae.2_3'UTR	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	235					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		CTTTGATGGGCCACTTCCAGG	0.493													49	61					2.31418e-15	3.53018e-15	0.003610	1	0
SLCO1A2	6579	broad.mit.edu	37	12	21457412	21457412	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:21457412T>C	uc001rer.2	-	5	789	c.538A>G	c.(538-540)ATT>GTT	p.I180V	SLCO1A2_uc001res.2_Missense_Mutation_p.I180V|SLCO1A2_uc010siq.1_Missense_Mutation_p.I48V|SLCO1A2_uc010sio.1_Missense_Mutation_p.I48V|SLCO1A2_uc010sip.1_Missense_Mutation_p.I48V|SLCO1A2_uc001ret.2_Missense_Mutation_p.I178V|SLCO1A2_uc001reu.2_Missense_Mutation_p.I160V	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	180	Helical; Name=4; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						ATATAGGAAATACCCAAAGGC	0.353													15	26					0	0	0.002450	0	0
GYS2	2998	broad.mit.edu	37	12	21699379	21699379	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:21699379G>A	uc001rfb.2	-	12	1703	c.1448C>T	c.(1447-1449)TCC>TTC	p.S483F		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	483			S -> P (in GSD0).		glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						ACTGGTGGAGGATAGAAACTC	0.363													12	15					0	0	0.000978	0	0
GYS2	2998	broad.mit.edu	37	12	21733318	21733318	+	Silent	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:21733318A>C	uc001rfb.2	-	2	516	c.261T>G	c.(259-261)GCT>GCG	p.A87A		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	87					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						CTCTTCTGACAGCATCATTTA	0.418													41	63					0	0	0.003610	0	0
KIAA0528	9847	broad.mit.edu	37	12	22623806	22623806	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:22623806G>A	uc001rfq.2	-	21	2626	c.2398C>T	c.(2398-2400)CAG>TAG	p.Q800*	KIAA0528_uc010sir.1_Nonsense_Mutation_p.Q615*|KIAA0528_uc010sis.1_Nonsense_Mutation_p.Q800*|KIAA0528_uc010sit.1_Nonsense_Mutation_p.Q802*|KIAA0528_uc010siu.1_Nonsense_Mutation_p.Q800*|KIAA0528_uc001rfr.2_Nonsense_Mutation_p.Q791*	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	800							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TGTAAAGCCTGATTTTTGTCA	0.343													25	23					0	0	0.004656	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	T	T	rs121913529		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:25398284C>T	uc001rgp.1	-	2	216	c.35G>A	c.(34-36)GGT>GAT	p.G12D	KRAS_uc001rgq.1_Missense_Mutation_p.G12D|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			44	2					0	0	0.003610	0	0
SYT10	341359	broad.mit.edu	37	12	33579230	33579230	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:33579230C>T	uc001rll.1	-	2	649	c.352G>A	c.(352-354)GAA>AAA	p.E118K	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	118	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTTTCATTTTCCTTAATTTCT	0.408													40	190					0	0	0.006230	0	0
C12orf40	283461	broad.mit.edu	37	12	40041606	40041606	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:40041606G>A	uc001rmc.2	+	6	564	c.397G>A	c.(397-399)GAC>AAC	p.D133N	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	133										ovary(6)	6						ACAAGGCATGGACTCATATAG	0.328													10	33					0	0	0.001368	0	0
LRRK2	120892	broad.mit.edu	37	12	40677810	40677810	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:40677810G>A	uc001rmg.3	+	19	2496	c.2375G>A	c.(2374-2376)AGG>AAG	p.R792K	LRRK2_uc001rmh.1_Missense_Mutation_p.R414K	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	792					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTGCTCTTAAGGAGGCTGGCC	0.443													27	59					0	0	0.007291	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42853643	42853644	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:42853643_42853644CC>TT	uc010skv.1	-	8	2750_2751	c.2463_2464GG>AA	c.(2461-2466)AAGGGA>AAAAGA	p.G822R	PRICKLE1_uc001rnl.2_Missense_Mutation_p.G822R|PRICKLE1_uc010skw.1_Missense_Mutation_p.G822R|PRICKLE1_uc001rnm.2_Missense_Mutation_p.G822R|PRICKLE1_uc001rnk.1_5'Flank	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	822					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		CCCTTGTGTCCCTTTTTCTTCT	0.401													22	103					0	0	0.004672	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43858432	43858432	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:43858432G>A	uc010skx.1	-	10	1471	c.1471C>T	c.(1471-1473)CTT>TTT	p.L491F		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	491	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCAAACGCAAGCTCACACTGC	0.373													36	89					0	0	0.006230	0	0
TMEM117	84216	broad.mit.edu	37	12	44238710	44238710	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:44238710C>T	uc001rod.2	+	2	322	c.256C>T	c.(256-258)CTG>TTG	p.L86L	TMEM117_uc001roe.2_Missense_Mutation_p.S15F|TMEM117_uc009zkc.2_Silent_p.L86L	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	86	Helical; (Potential).					endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TGGCAAATTTCTGTTCCATCA	0.358													30	63					0	0	0.002836	0	0
DBX2	440097	broad.mit.edu	37	12	45410236	45410236	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:45410236G>T	uc001rok.1	-	4	1025	c.853C>A	c.(853-855)CAG>AAG	p.Q285K		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	285						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		CTTGAGTGCTGTTGGGGGACG	0.512													24	74					2.49675e-24	3.82083e-24	0.007291	1	0
FAM113B	91523	broad.mit.edu	37	12	47630108	47630108	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:47630108G>A	uc001rpn.2	+	4	1993	c.1262G>A	c.(1261-1263)AGA>AAA	p.R421K	FAM113B_uc001rpq.2_Missense_Mutation_p.R421K	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	421	Pro-rich.						hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					CCTTCAAAGAGAAGGGCCCCA	0.562													4	12					0	0	0.000248	0	0
HDAC7	51564	broad.mit.edu	37	12	48191223	48191223	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:48191223G>A	uc009zkv.1	-	4	619	c.404C>T	c.(403-405)CCT>CTT	p.P135L	HDAC7_uc010slo.1_Missense_Mutation_p.P174L|HDAC7_uc001rqj.3_Missense_Mutation_p.P174L|HDAC7_uc001rqk.3_Missense_Mutation_p.P157L			Q8WUI4	HDAC7_HUMAN	Synthetic construct DNA, clone: pF1KB0470, Homo sapiens HDAC7 gene for histone deacetylase 7, without stop codon, in Flexi system.	135	Interaction with MEF2A (By similarity).|Transcription repression 1 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		GGGAACAGGAGGCAAAAAGCT	0.612													29	72					0	0	0.002096	0	0
COL2A1	1280	broad.mit.edu	37	12	48367243	48367243	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:48367243C>T	uc001rqu.2	-	54	4592	c.4411G>A	c.(4411-4413)GGA>AGA	p.G1471R	COL2A1_uc001rqt.2_Missense_Mutation_p.G252R|COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.G1402R	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	1471	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TCGGGCCCTCCTATGTCCATG	0.527													36	88					0	0	0.005524	0	0
COL2A1	1280	broad.mit.edu	37	12	48380960	48380960	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:48380960C>T	uc001rqu.2	-	21	1448	c.1267_splice	c.e21-1	p.G423_splice	COL2A1_uc009zkw.2_Splice_Site|COL2A1_uc001rqv.2_Splice_Site_p.G354_splice	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor						axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CAGGAGCACCCTGTGGGCATG	0.647													24	55					0	0	0.002780	0	0
ADCY6	112	broad.mit.edu	37	12	49162479	49162479	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:49162479C>T	uc001rsh.3	-	21	4062	c.3402G>A	c.(3400-3402)CAG>CAA	p.Q1134Q	ADCY6_uc001rsj.3_Silent_p.Q1134Q|ADCY6_uc001rsi.3_Silent_p.Q1081Q	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	1134	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CAGCTAGAACCTGGTACAGGT	0.622													21	44					0	0	0.002299	0	0
ADCY6	112	broad.mit.edu	37	12	49177038	49177038	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:49177038G>A	uc001rsh.3	-	1	840	c.180C>T	c.(178-180)CCC>CCT	p.P60P	ADCY6_uc001rsj.3_Silent_p.P60P|ADCY6_uc001rsi.3_Silent_p.P60P	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	60	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						GGCACCGAGGGGGGCCCGCAG	0.721													7	17					0	0	0.001984	0	0
MLL2	8085	broad.mit.edu	37	12	49435896	49435896	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:49435896G>A	uc001rta.3	-	28	6085	c.6085C>T	c.(6085-6087)CCT>TCT	p.P2029S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2029					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTGAGATTAGGAAAATTAATG	0.542			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			4	27					0	0	0.001168	0	0
KCNH3	23416	broad.mit.edu	37	12	49951630	49951630	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:49951630G>A	uc001ruh.1	+	15	3406	c.3146G>A	c.(3145-3147)GGG>GAG	p.G1049E	KCNH3_uc010smj.1_Missense_Mutation_p.G989E	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	1049	Pro-rich.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						CCAGGGTCAGGGGGCCTGGCC	0.667													6	25					0	0	0.003080	0	0
MCRS1	10445	broad.mit.edu	37	12	49958267	49958267	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:49958267G>A	uc001ruk.1	-	6	745	c.554C>T	c.(553-555)TCC>TTC	p.S185F	MCRS1_uc001rui.1_Missense_Mutation_p.S198F|MCRS1_uc001ruj.1_Missense_Mutation_p.S172F|MCRS1_uc001rul.1_Missense_Mutation_p.S185F|MCRS1_uc009zlj.1_5'UTR|MCRS1_uc001rum.1_Missense_Mutation_p.S172F|MCRS1_uc001run.1_Missense_Mutation_p.S185F	NM_006337	NP_006328	Q96EZ8	MCRS1_HUMAN	microspherule protein 1 isoform 1	185					DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			large_intestine(1)	1						CACTCACTTGGAGATGACAGG	0.607													7	11					0	0	0.004482	0	0
SLC11A2	4891	broad.mit.edu	37	12	51384698	51384698	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:51384698A>G	uc001rxe.3	-	15	1552	c.1455T>C	c.(1453-1455)CTT>CTC	p.L485L	SLC11A2_uc001rxd.3_Silent_p.L334L|SLC11A2_uc001rxc.3_Silent_p.L485L|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_Silent_p.L98L|SLC11A2_uc010smx.1_Silent_p.L481L|SLC11A2_uc001rxh.1_Silent_p.L485L|SLC11A2_uc001rxj.1_Silent_p.L485L|SLC11A2_uc001rxi.2_Silent_p.L485L|SLC11A2_uc001rxk.1_Silent_p.L514L|SLC11A2_uc010smy.1_Silent_p.L448L	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	485	Helical; (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						AACAGATGATAAGGACCAAGA	0.463													12	27					0	0	0.001855	0	0
SLC11A2	4891	broad.mit.edu	37	12	51384701	51384701	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:51384701G>A	uc001rxe.3	-	15	1549	c.1452C>T	c.(1450-1452)GTC>GTT	p.V484V	SLC11A2_uc001rxd.3_Silent_p.V333V|SLC11A2_uc001rxc.3_Silent_p.V484V|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_Silent_p.V97V|SLC11A2_uc010smx.1_Silent_p.V480V|SLC11A2_uc001rxh.1_Silent_p.V484V|SLC11A2_uc001rxj.1_Silent_p.V484V|SLC11A2_uc001rxi.2_Silent_p.V484V|SLC11A2_uc001rxk.1_Silent_p.V513V|SLC11A2_uc010smy.1_Silent_p.V447V	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	484	Helical; (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						AGATGATAAGGACCAAGATTC	0.468													12	25					0	0	0.001855	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284460	52284460	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52284460C>T	uc001rzf.3	+	5	934	c.355C>T	c.(355-357)CGG>TGG	p.R119W	ANKRD33_uc001rzh.3_3'UTR|ANKRD33_uc001rzd.2_Missense_Mutation_p.R244W|ANKRD33_uc001rze.2_Missense_Mutation_p.R140W|ANKRD33_uc001rzg.3_Missense_Mutation_p.R46W|ANKRD33_uc001rzi.3_Missense_Mutation_p.R119W	NM_001130015	NP_001123487	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33 isoform 1	119	ANK 3.										0				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GTGGAGGATTCGGCAGCTGCT	0.582													12	34					0	0	0.001855	0	0
KRT7	3855	broad.mit.edu	37	12	52641960	52641960	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52641960G>A	uc001saa.1	+	8	1333	c.1206_splice	c.e8-1	p.R402_splice	KRT86_uc010snq.1_5'Flank|KRT7_uc009zmf.1_Splice_Site_p.V329_splice	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7						cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		TCTGCCCCCAGGTTGGCTGGA	0.582													12	45					0	0	0.001855	0	0
KRT83	3889	broad.mit.edu	37	12	52715036	52715036	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52715036G>A	uc001saf.2	-	1	147	c.84C>T	c.(82-84)AGC>AGT	p.S28S		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	28	Head.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGCAGCAGCGGCTTGGCCGGG	0.682													23	77					0	0	0.002780	0	0
KRT84	3890	broad.mit.edu	37	12	52778905	52778905	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52778905G>A	uc001sah.1	-	1	513	c.465C>T	c.(463-465)GAC>GAT	p.D155D		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	155	Head.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GGGCATTGGGGTCAATCTCCA	0.502													56	313					0	0	0.003610	0	0
KRT6B	3854	broad.mit.edu	37	12	52841607	52841607	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52841607A>C	uc001sak.2	-	7	1427	c.1379T>G	c.(1378-1380)GTG>GGG	p.V460G		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	460	Rod.|Coil 2.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		GGCGATCTCCACATCCAGGGC	0.612													29	84					0	0	0.003271	0	0
KRT6C	286887	broad.mit.edu	37	12	52864331	52864331	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52864331C>T	uc001sal.3	-	6	1209	c.1161G>A	c.(1159-1161)ATG>ATA	p.M387I		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	387	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GCCTCTGGATCATGCGGTTGA	0.547													24	77					0	0	0.005443	0	0
KRT71	112802	broad.mit.edu	37	12	52940286	52940286	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52940286G>A	uc001sao.2	-	7	1179	c.1109C>T	c.(1108-1110)TCC>TTC	p.S370F		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	370	Coil 2.|Rod.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		CTCCAGGTTGGAAGCCTAAGG	0.597													7	16					0	0	0.001984	0	0
KRT79	338785	broad.mit.edu	37	12	53217696	53217696	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:53217696C>T	uc001sbb.2	-	6	1154	c.1121G>A	c.(1120-1122)GGG>GAG	p.G374E	KRT79_uc001sba.2_Missense_Mutation_p.G145E	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	374	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						ATCAGCCTCCCCCTGCAGCCT	0.612													16	22					0	0	0.004990	0	0
KRT8	3856	broad.mit.edu	37	12	53291216	53291216	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:53291216T>A	uc001sbd.2	-	8	1551	c.1448A>T	c.(1447-1449)AAG>ATG	p.K483M	KRT8_uc009zmj.2_3'UTR|KRT8_uc009zmk.1_Missense_Mutation_p.K511M|KRT8_uc009zml.1_Missense_Mutation_p.K483M|KRT8_uc009zmm.1_Missense_Mutation_p.K483M	NM_002273	NP_002264	P05787	K2C8_HUMAN	keratin 8	483	Tail.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCTGTTCACTTGGGCAGGAC	0.617													15	41					0	0	0.006122	0	0
SPRYD3	84926	broad.mit.edu	37	12	53468952	53468952	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:53468952G>A	uc001sbt.1	-	4	319	c.298C>T	c.(298-300)CCT>TCT	p.P100S	SPRYD3_uc010snw.1_5'UTR	NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	100	B30.2/SPRY.									central_nervous_system(1)	1						TAGTACTGAGGGACCAGCCCC	0.582													34	96					0	0	0.003271	0	0
CALCOCO1	57658	broad.mit.edu	37	12	54107577	54107577	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:54107577G>A	uc001sef.2	-	13	1843	c.1699C>T	c.(1699-1701)CCT>TCT	p.P567S	CALCOCO1_uc001see.2_Missense_Mutation_p.P68S|CALCOCO1_uc010som.1_Missense_Mutation_p.P482S|CALCOCO1_uc010son.1_Missense_Mutation_p.P444S|CALCOCO1_uc001seh.2_Missense_Mutation_p.P567S|CALCOCO1_uc009znd.2_Missense_Mutation_p.P567S|CALCOCO1_uc001seg.2_Missense_Mutation_p.P392S	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	567	C-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						GCCTCTCGAGGCCCAGCAGGA	0.612													33	56					0	0	0.003755	0	0
HOXC8	3224	broad.mit.edu	37	12	54404894	54404894	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:54404894G>A	uc001ser.2	+	2	637	c.458G>A	c.(457-459)CGG>CAG	p.R153Q		NM_022658	NP_073149	P31273	HXC8_HUMAN	homeobox C8	153	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CGCAGTGGACGGCAAACTTAC	0.488													16	46					0	0	0.004990	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54917708	54917708	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:54917708C>T	uc001sgc.3	+	20	2203	c.2124C>T	c.(2122-2124)TAC>TAT	p.Y708Y	NCKAP1L_uc010sox.1_Silent_p.Y250Y|NCKAP1L_uc010soy.1_Silent_p.Y658Y	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	708					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						CTTCTGAGTACCTCAGCAGCC	0.448													34	60					0	0	0.004878	0	0
OR6C75	390323	broad.mit.edu	37	12	55759263	55759263	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:55759263C>T	uc010spk.1	+	1	369	c.369C>T	c.(367-369)GCC>GCT	p.A123A		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						GCTGCATGGCCATCTGCAAAC	0.453													15	34					0	0	0.002450	0	0
OR6C76	390326	broad.mit.edu	37	12	55820729	55820729	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:55820729G>A	uc010spm.1	+	1	692	c.692G>A	c.(691-693)AGA>AAA	p.R231K		NM_001005183	NP_001005183	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCACAGCAAAGAAAAAAAGCC	0.368													17	27					0	0	0.006122	0	0
RAB5B	5869	broad.mit.edu	37	12	56380879	56380879	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:56380879C>T	uc001siv.2	+	2	252	c.135C>T	c.(133-135)TTC>TTT	p.F45F	RAB5B_uc001siw.2_Silent_p.F45F|RAB5B_uc009zog.2_Missense_Mutation_p.S36F|RAB5B_uc010spz.1_Silent_p.F45F	NM_002868	NP_002859	P61020	RAB5B_HUMAN	RAB5B, member RAS oncogene family	45					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|membrane fraction|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			AAGGGCAGTTCCATGAGTACC	0.418													25	48					0	0	0.002445	0	0
SUOX	6821	broad.mit.edu	37	12	56397697	56397697	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:56397697C>T	uc001six.2	+	6	850	c.524C>T	c.(523-525)CCT>CTT	p.P175L	SUOX_uc001siy.2_Missense_Mutation_p.P175L|SUOX_uc001siz.2_Missense_Mutation_p.P175L|SUOX_uc001sja.2_Missense_Mutation_p.P175L	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	175	Hinge (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			ACCTCTGACCCTTATGCTGAT	0.547													21	50					0	0	0.001523	0	0
SLC39A5	283375	broad.mit.edu	37	12	56625132	56625132	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:56625132C>T	uc010sqj.1	+	4	331	c.74C>T	c.(73-75)TCA>TTA	p.S25L	SLC39A5_uc010sqi.1_Intron|SLC39A5_uc010sqk.1_Missense_Mutation_p.S25L	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	25	Extracellular (By similarity).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2						GTAGGGGGCTCAGTCCCCAAC	0.622													27	94					0	0	0.004656	0	0
R3HDM2	22864	broad.mit.edu	37	12	57663588	57663588	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:57663588G>A	uc009zpm.1	-	13	1527	c.1492C>T	c.(1492-1494)CCA>TCA	p.P498S	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_Missense_Mutation_p.P193S|R3HDM2_uc001snr.2_Missense_Mutation_p.P225S|R3HDM2_uc001sns.2_Missense_Mutation_p.P498S|R3HDM2_uc001snt.2_Missense_Mutation_p.P512S|R3HDM2_uc009zpn.1_Missense_Mutation_p.P121S	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	498	Gln-rich.					nucleus	nucleic acid binding			ovary(2)	2						TGAGTAGGTGGTGCATGGCTA	0.547													21	48					0	0	0.001882	0	0
R3HDM2	22864	broad.mit.edu	37	12	57677620	57677620	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:57677620C>T	uc009zpm.1	-	11	1151	c.1116G>A	c.(1114-1116)AGG>AGA	p.R372R	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_Silent_p.R33R|R3HDM2_uc001snr.2_Silent_p.R99R|R3HDM2_uc001sns.2_Silent_p.R372R|R3HDM2_uc001snt.2_Silent_p.R386R	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	372						nucleus	nucleic acid binding			ovary(2)	2						GCCTGGAGATCCTTCCCGCAC	0.483													65	129					0	0	0.003610	0	0
GLI1	2735	broad.mit.edu	37	12	57861832	57861832	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:57861832C>T	uc001snx.2	+	10	1211	c.1133C>T	c.(1132-1134)TCG>TTG	p.S378L	GLI1_uc009zpq.2_Missense_Mutation_p.S250L	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	378	C2H2-type 5.				epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			GATCCTAGCTCGCTGCGAAAA	0.552													8	34					0	0	0.006214	0	0
OS9	10956	broad.mit.edu	37	12	58113946	58113946	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:58113946G>A	uc001spj.2	+	13	1724	c.1665G>A	c.(1663-1665)CAG>CAA	p.Q555Q	OS9_uc010srx.1_Intron|OS9_uc001spk.2_Silent_p.Q540Q|OS9_uc001spl.2_Intron|OS9_uc001spm.2_Intron|OS9_uc001spn.2_Intron|OS9_uc010sry.1_Intron|OS9_uc010srz.1_Intron	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	555					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GCCCTAATCAGGATCTGACTG	0.577													46	71					0	0	0.003214	0	0
CYP27B1	1594	broad.mit.edu	37	12	58158686	58158686	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:58158686C>T	uc001spz.1	-	5	966	c.814G>A	c.(814-816)GAG>AAG	p.E272K	CYP27B1_uc001sqa.1_Missense_Mutation_p.E37K|CYP27B1_uc001sqb.1_Missense_Mutation_p.R152K|CYP27B1_uc001sqc.1_Missense_Mutation_p.R152K	NM_000785	NP_000776	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B,	272					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)	3	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	GCCTCTGCCTCTCGCCGCTCC	0.617													23	64					0	0	0.003330	0	0
XPOT	11260	broad.mit.edu	37	12	64815032	64815032	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:64815032C>T	uc001ssb.2	+	9	1287	c.861C>T	c.(859-861)TTC>TTT	p.F287F	XPOT_uc009zqm.1_Silent_p.F197F	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	287	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		ATGTTGACTTCCTGGCCAGAT	0.363													41	98					0	0	0.002852	0	0
YEATS4	8089	broad.mit.edu	37	12	69756643	69756643	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:69756643C>T	uc001sux.2	+	2	348	c.127C>T	c.(127-129)CAC>TAC	p.H43Y		NM_006530	NP_006521	O95619	YETS4_HUMAN	glioma-amplified sequence-41	43	YEATS.				histone H2A acetylation|histone H4 acetylation|mitosis|positive regulation of transcription, DNA-dependent|regulation of growth	NuA4 histone acetyltransferase complex|nuclear matrix	DNA binding|protein C-terminus binding|sequence-specific DNA binding transcription factor activity|structural constituent of cytoskeleton				0	all_epithelial(5;9.25e-35)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;6.89e-18)|BRCA - Breast invasive adenocarcinoma(5;3.14e-09)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			AGAAGATGGGCACACTCATCA	0.318													22	66					0	0	0.002299	0	0
PTPRB	5787	broad.mit.edu	37	12	70946726	70946726	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:70946726G>A	uc001swb.3	-	19	4594	c.4564C>T	c.(4564-4566)CGG>TGG	p.R1522W	PTPRB_uc010sto.1_Missense_Mutation_p.R1432W|PTPRB_uc010stp.1_Missense_Mutation_p.R1432W|PTPRB_uc001swc.3_Missense_Mutation_p.R1740W|PTPRB_uc001swa.3_Missense_Mutation_p.R1652W	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1522	Fibronectin type-III 17.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGATACACCCGAATGGAGGCA	0.483													49	105					0	0	0.003610	0	0
PTPRB	5787	broad.mit.edu	37	12	70953240	70953240	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:70953240C>T	uc001swb.3	-	16	3973	c.3943G>A	c.(3943-3945)GAA>AAA	p.E1315K	PTPRB_uc010sto.1_Missense_Mutation_p.E1225K|PTPRB_uc010stp.1_Missense_Mutation_p.E1225K|PTPRB_uc001swc.3_Missense_Mutation_p.E1533K|PTPRB_uc001swa.3_Missense_Mutation_p.E1445K|PTPRB_uc001swd.3_Missense_Mutation_p.E1532K|PTPRB_uc009zrr.1_Missense_Mutation_p.E1412K	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1315	Fibronectin type-III 15.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ATGCGTCCTTCTGATTTTCTG	0.468													63	169					0	0	0.003610	0	0
TSPAN8	7103	broad.mit.edu	37	12	71519129	71519129	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:71519129C>T	uc009zrt.1	-	8	861	c.699G>A	c.(697-699)CAG>CAA	p.Q233Q	TSPAN8_uc001swk.1_Silent_p.Q233Q|TSPAN8_uc001swj.1_Silent_p.Q233Q	NM_004616	NP_004607	P19075	TSN8_HUMAN	transmembrane 4 superfamily member 3	233	Cytoplasmic (Potential).				protein glycosylation	integral to membrane|lysosome	signal transducer activity			skin(2)|lung(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			TGTTCCCGATCTGGCAATACA	0.353													95	237					0	0	0.003610	0	0
TSPAN8	7103	broad.mit.edu	37	12	71519134	71519134	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:71519134A>C	uc009zrt.1	-	8	856	c.694T>G	c.(694-696)TGC>GGC	p.C232G	TSPAN8_uc001swk.1_Missense_Mutation_p.C232G|TSPAN8_uc001swj.1_Missense_Mutation_p.C232G	NM_004616	NP_004607	P19075	TSN8_HUMAN	transmembrane 4 superfamily member 3	232	Cytoplasmic (Potential).				protein glycosylation	integral to membrane|lysosome	signal transducer activity			skin(2)|lung(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			CCGATCTGGCAATACAGGACC	0.353													99	235					0	0	0.003610	0	0
TRHDE	29953	broad.mit.edu	37	12	72956740	72956740	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:72956740A>T	uc001sxa.2	+	9	1857	c.1827A>T	c.(1825-1827)GAA>GAT	p.E609D		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	609	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CAACAGCAGAAAATAGAATAA	0.328													28	106					0	0	0.005443	0	0
NAV3	89795	broad.mit.edu	37	12	78513382	78513382	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:78513382C>T	uc001syp.2	+	15	3579	c.3406C>T	c.(3406-3408)CGC>TGC	p.R1136C	NAV3_uc001syo.2_Missense_Mutation_p.R1136C|NAV3_uc010sub.1_Missense_Mutation_p.R636C|NAV3_uc009zsf.2_Missense_Mutation_p.R144C	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1136	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CCTACAATATCGCAGCTTGCC	0.512										HNSCC(70;0.22)			13	51					0	0	0.001368	0	0
NAV3	89795	broad.mit.edu	37	12	78516075	78516075	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:78516075C>T	uc001syp.2	+	16	4278	c.4105C>T	c.(4105-4107)CTC>TTC	p.L1369F	NAV3_uc001syo.2_Missense_Mutation_p.L1369F|NAV3_uc010sub.1_Missense_Mutation_p.L869F|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1369	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CATGACTAGCCTCCACACGAG	0.567										HNSCC(70;0.22)			31	48					0	0	0.001786	0	0
NAV3	89795	broad.mit.edu	37	12	78604241	78604241	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:78604241G>A	uc001syp.2	+	40	7275	c.7102G>A	c.(7102-7104)GAA>AAA	p.E2368K	NAV3_uc001syo.2_Missense_Mutation_p.E2346K|NAV3_uc010sub.1_Missense_Mutation_p.E1825K|NAV3_uc009zsf.2_Missense_Mutation_p.E1177K	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2368						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTGCGACAGCGAAAGCACCAG	0.388										HNSCC(70;0.22)			8	36					0	0	0.004482	0	0
LIN7A	8825	broad.mit.edu	37	12	81239577	81239577	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:81239577G>A	uc001szj.1	-	4	608	c.415C>T	c.(415-417)CCT>TCT	p.P139S	LIN7A_uc001szk.1_RNA	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	139	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						ACCCCTCCAGGAATTATGCGA	0.458													34	67					0	0	0.003755	0	0
ACSS3	79611	broad.mit.edu	37	12	81536964	81536964	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:81536964C>T	uc001szl.1	+	5	950	c.859C>T	c.(859-861)CCT>TCT	p.P287S	ACSS3_uc001szm.1_Missense_Mutation_p.P286S	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	287						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TGACTGTGTTCCTGTTCTTTC	0.448													18	44					0	0	0.007413	0	0
SLC6A15	55117	broad.mit.edu	37	12	85255683	85255683	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:85255683G>A	uc001szv.2	-	12	2414	c.1921C>T	c.(1921-1923)CGC>TGC	p.R641C	SLC6A15_uc010sul.1_Missense_Mutation_p.R534C|SLC6A15_uc001szw.1_Intron	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	641	Helical; Name=12; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						AGGTTGAAGCGACGAACAATG	0.433													32	107					0	0	0.001786	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85450849	85450849	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:85450849C>T	uc001tac.2	+	8	2389	c.2278C>T	c.(2278-2280)CAA>TAA	p.Q760*	LRRIQ1_uc001tab.1_Nonsense_Mutation_p.Q760*|LRRIQ1_uc001taa.1_Nonsense_Mutation_p.Q735*	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	760										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CAAGCAAAATCAACAAAAGAA	0.393													79	199					0	0	0.003610	0	0
ATP2B1	490	broad.mit.edu	37	12	90010769	90010769	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:90010769G>A	uc001tbh.2	-	11	2058	c.1877C>T	c.(1876-1878)CCA>CTA	p.P626L	ATP2B1_uc001tbg.2_Missense_Mutation_p.P626L|ATP2B1_uc001tbf.2_Missense_Mutation_p.P296L	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	626	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						ACGGTCCCTTGGTCTGAATAC	0.358													27	83					0	0	0.004656	0	0
KERA	11081	broad.mit.edu	37	12	91445201	91445201	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:91445201C>T	uc001tbl.2	-	3	1600	c.981G>A	c.(979-981)CTG>CTA	p.L327L		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	327					response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						CATTTCCATCCAGACGGAGGT	0.438													20	40					0	0	0.008871	0	0
SOCS2	8835	broad.mit.edu	37	12	93968784	93968785	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:93968784_93968785CC>TT	uc001tcw.1	+	3	1016_1017	c.426_427CC>TT	c.(424-429)GCCCCC>GCTTCC	p.P143S	SOCS2_uc001tcx.1_Missense_Mutation_p.P143S|SOCS2_uc009zsu.2_3'UTR|SOCS2_uc001tcy.1_Missense_Mutation_p.P143S|SOCS2_uc001tcz.2_3'UTR	NM_003877	NP_003868	O14508	SOCS2_HUMAN	suppressor of cytokine signaling-2	143	SH2.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity			lung(1)	1						GTCCAGAAGCCCCCCGGAACGG	0.475													13	37					0	0	0.004672	0	0
FGD6	55785	broad.mit.edu	37	12	95604835	95604835	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:95604835G>A	uc001tdp.3	-	2	449	c.225C>T	c.(223-225)ATC>ATT	p.I75I	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	75					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						GGTTCAACATGATTTTCCTTG	0.408													80	214					0	0	0.003610	0	0
C12orf63	374467	broad.mit.edu	37	12	97073463	97073463	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:97073463C>T	uc001tet.1	+	7	1002	c.924C>T	c.(922-924)TCC>TCT	p.S308S		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	308										skin(6)|ovary(1)	7						TGGAAAAATCCAAATACCATA	0.428													46	83					0	0	0.002522	0	0
C12orf63	374467	broad.mit.edu	37	12	97073495	97073495	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:97073495G>A	uc001tet.1	+	7	1034	c.956G>A	c.(955-957)AGA>AAA	p.R319K		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	319										skin(6)|ovary(1)	7						CGACACAGCAGAAAGTTGCTT	0.453													34	94					0	0	0.005524	0	0
C12orf63	374467	broad.mit.edu	37	12	97078989	97078989	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:97078989G>A	uc001tet.1	+	9	1340	c.1262G>A	c.(1261-1263)GGA>GAA	p.G421E		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	421										skin(6)|ovary(1)	7						TGTTTGCAAGGAGCAGTCATA	0.507													16	44					0	0	0.008871	0	0
APAF1	317	broad.mit.edu	37	12	99060005	99060005	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:99060005T>C	uc001tfz.2	+	9	1809	c.1232T>C	c.(1231-1233)GTT>GCT	p.V411A	APAF1_uc001tfy.2_Missense_Mutation_p.V400A|APAF1_uc001tga.2_Missense_Mutation_p.V400A|APAF1_uc001tgb.2_Missense_Mutation_p.V411A|APAF1_uc001tgc.2_Intron	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	411	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	ACTGAAGAAGTTGAAGACATA	0.348													27	86					0	0	0.001786	0	0
SCYL2	55681	broad.mit.edu	37	12	100720500	100720500	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:100720500C>T	uc001thn.2	+	12	1660	c.1610C>T	c.(1609-1611)TCC>TTC	p.S537F	SCYL2_uc009ztw.1_Missense_Mutation_p.S364F|SCYL2_uc001thm.1_Missense_Mutation_p.S537F	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	537					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						CAAATTCCATCCAAGGAACCT	0.333													18	37					0	0	0.007413	0	0
SLC17A8	246213	broad.mit.edu	37	12	100751232	100751232	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:100751232G>A	uc010svi.1	+	1	376	c.63G>A	c.(61-63)GTG>GTA	p.V21V	SLC17A8_uc009ztx.2_Silent_p.V21V	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	21	Cytoplasmic (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						AGGAAGGAGTGAAGAACGCCG	0.408													19	66					0	0	0.001523	0	0
SLC17A8	246213	broad.mit.edu	37	12	100784803	100784803	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:100784803G>A	uc010svi.1	+	3	692	c.379G>A	c.(379-381)GAA>AAA	p.E127K	SLC17A8_uc009ztx.2_Missense_Mutation_p.E127K	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	127	Vesicular (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						CTGGGATCCAGAAACAGTGGG	0.388													28	70					0	0	0.008361	0	0
IGF1	3479	broad.mit.edu	37	12	102813337	102813337	+	Missense_Mutation	SNP	C	T	T	rs151098426	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:102813337C>T	uc001tjp.3	-	3	571	c.352G>A	c.(352-354)GCT>ACT	p.A118T	IGF1_uc001tjn.2_Missense_Mutation_p.A102T|IGF1_uc001tjm.2_Missense_Mutation_p.A118T|IGF1_uc001tjo.2_Missense_Mutation_p.A118T	NM_001111285	NP_001104755	P05019	IGF1_HUMAN	insulin-like growth factor 1 isoform 3	118	D.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|pancreas(1)	2						ACAGAGCGAGCTGACTTGGCA	0.607													11	25					0	0	0.008291	0	0
STAB2	55576	broad.mit.edu	37	12	104014257	104014257	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:104014257G>A	uc001tjw.2	+	4	529	c.343G>A	c.(343-345)GGA>AGA	p.G115R		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	115	Extracellular (Potential).|EGF-like 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GTGCCCAGGTGGAGCGGGGTC	0.488													5	8					0	0	0.001168	0	0
STAB2	55576	broad.mit.edu	37	12	104042572	104042572	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:104042572G>A	uc001tjw.2	+	10	1331	c.1145G>A	c.(1144-1146)GGA>GAA	p.G382E		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	382	Extracellular (Potential).|FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AAATGGCAAGGAAGGCTGACC	0.443													37	74					0	0	0.006230	0	0
APPL2	55198	broad.mit.edu	37	12	105591619	105591619	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:105591619C>T	uc001tlf.1	-	11	1194	c.976G>A	c.(976-978)GAC>AAC	p.D326N	APPL2_uc010swt.1_Missense_Mutation_p.D283N|APPL2_uc001tlg.1_Missense_Mutation_p.D80N|APPL2_uc010swu.1_Missense_Mutation_p.D332N|APPL2_uc009zuq.2_Missense_Mutation_p.D283N	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	326	Required for RAB5A binding (By similarity).|PH.				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						GAGCAGTTGTCCAGGTCCTGG	0.552													17	48					0	0	0.004990	0	0
CRY1	1407	broad.mit.edu	37	12	107391350	107391350	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:107391350T>A	uc001tmi.3	-	9	2267	c.1408A>T	c.(1408-1410)ATG>TTG	p.M470L		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	470	Required for inhibition of CLOCK-ARNTL- mediated transcription (By similarity).|FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						TGGTTCACCATTGGTTTAGGA	0.403													25	76					0	0	0.005443	0	0
CRY1	1407	broad.mit.edu	37	12	107391385	107391385	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:107391385G>A	uc001tmi.3	-	9	2232	c.1373C>T	c.(1372-1374)GCC>GTC	p.A458V		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	458	Required for inhibition of CLOCK-ARNTL- mediated transcription (By similarity).|FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						CAAACATTTGGCTACCTTTTG	0.413													16	60					0	0	0.006122	0	0
BTBD11	121551	broad.mit.edu	37	12	108051454	108051454	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:108051454C>T	uc001tmk.1	+	17	3795	c.3274C>T	c.(3274-3276)CAG>TAG	p.Q1092*	BTBD11_uc001tml.1_Nonsense_Mutation_p.Q629*|BTBD11_uc001tmm.1_Nonsense_Mutation_p.Q171*	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	1092						integral to membrane	DNA binding			skin(2)|ovary(1)	3						CATCAGAATTCAGTCCATCCA	0.512													30	73					0	0	0.002445	0	0
WSCD2	9671	broad.mit.edu	37	12	108634201	108634201	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:108634201G>A	uc001tms.2	+	8	1969	c.1225G>A	c.(1225-1227)GAG>AAG	p.E409K	WSCD2_uc001tmt.2_Missense_Mutation_p.E409K|WSCD2_uc001tmu.2_Missense_Mutation_p.E157K	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	409						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GAAAGAGATCGAGGCCTTCGA	0.607													43	95					0	0	0.003214	0	0
MYO1H	283446	broad.mit.edu	37	12	109879455	109879455	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:109879455G>A	uc010sxo.1	+	3	374	c.99G>A	c.(97-99)AGG>AGA	p.R33R	MYO1H_uc010sxn.1_Silent_p.R842R			Q8N1T3	MYO1H_HUMAN	SubName: Full=cDNA FLJ54829, moderately similar to Myosin Ic; SubName: Full=Myosin IH, isoform CRA_a;	33						myosin complex	motor activity				0						AAATCTTCAGGGGAAGGAAAG	0.398													6	31					0	0	0.001168	0	0
TRPV4	59341	broad.mit.edu	37	12	110252389	110252389	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:110252389G>A	uc001tpj.1	-	1	308	c.213C>T	c.(211-213)TTC>TTT	p.F71F	TRPV4_uc001tpg.1_Silent_p.F37F|TRPV4_uc001tph.1_Silent_p.F71F|TRPV4_uc001tpi.1_Silent_p.F71F|TRPV4_uc001tpk.1_Silent_p.F71F|TRPV4_uc001tpl.1_Silent_p.F71F	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	71	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AGGCGCCCTGGAACTTCATGC	0.632													9	28					0	0	0.006214	0	0
GIT2	9815	broad.mit.edu	37	12	110429562	110429562	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:110429562G>A	uc001tps.2	-	2	221	c.56C>T	c.(55-57)CCT>CTT	p.P19L	GIT2_uc001tpq.2_Missense_Mutation_p.P19L|GIT2_uc001tpv.2_Missense_Mutation_p.P19L|GIT2_uc001tpu.2_Missense_Mutation_p.P19L|GIT2_uc001tpt.2_Missense_Mutation_p.P19L|GIT2_uc010sxu.1_Intron|GIT2_uc001tpw.2_Missense_Mutation_p.P19L|GIT2_uc010sxv.1_Missense_Mutation_p.P19L	NM_057169	NP_476510	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting	19	Arf-GAP.|C4-type.				regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			central_nervous_system(1)	1						TGCCCAGGAAGGATCTGGAAA	0.478													16	48					0	0	0.007413	0	0
TCTN1	79600	broad.mit.edu	37	12	111085590	111085590	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:111085590A>G	uc009zvs.2	+	14	1765	c.1657A>G	c.(1657-1659)ACT>GCT	p.T553A	TCTN1_uc001trp.3_Missense_Mutation_p.T539A|TCTN1_uc001trn.3_Missense_Mutation_p.T558A|TCTN1_uc001trk.3_RNA|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	553					multicellular organismal development	extracellular region					0						TCTTATTTCCACTGCGGTTAC	0.498													20	46					0	0	0.008871	0	0
CUX2	23316	broad.mit.edu	37	12	111785550	111785550	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:111785550C>T	uc001tsa.1	+	22	4035	c.3882C>T	c.(3880-3882)GCC>GCT	p.A1294A		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1294						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						AGGACAAGGCCCAAGTGAGGA	0.607													5	28					0	0	0.001168	0	0
OAS3	4940	broad.mit.edu	37	12	113384571	113384571	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:113384571G>A	uc001tug.2	+	4	747	c.660G>A	c.(658-660)AAG>AAA	p.K220K		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	220	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						GGTTGTGGAAGGAGACGCTGC	0.587													3	17					0	0	0.004672	0	0
TPCN1	53373	broad.mit.edu	37	12	113717964	113717964	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:113717964A>G	uc001tuw.2	+	15	1603	c.1306A>G	c.(1306-1308)ATC>GTC	p.I436V	TPCN1_uc001tux.2_Missense_Mutation_p.I508V|TPCN1_uc010syt.1_Missense_Mutation_p.I368V	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	436	Cytoplasmic (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						AGGTATTAATATCCTTGTGAA	0.393													16	54					0	0	0.008871	0	0
NOS1	4842	broad.mit.edu	37	12	117768218	117768218	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:117768218C>T	uc001twm.1	-	2	1343	c.657G>A	c.(655-657)GGG>GGA	p.G219G		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	219	PIN (nNOS-inhibiting protein) binding.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCCCTCTGCTCCCACTGGTGA	0.522													45	95					0	0	0.003610	0	0
CCDC64	92558	broad.mit.edu	37	12	120502557	120502557	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:120502557G>A	uc001txl.1	+	4	808	c.783G>A	c.(781-783)CGG>CGA	p.R261R	CCDC64_uc001txk.2_Silent_p.R261R|CCDC64_uc009zwv.1_RNA|CCDC64_uc010sze.1_Silent_p.R5R	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	261	Potential.				Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGTCAGATCGGAAACGGGAGC	0.557													44	94					0	0	0.002522	0	0
SIRT4	23409	broad.mit.edu	37	12	120741753	120741753	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:120741753C>T	uc001tyc.2	+	2	409	c.389C>T	c.(388-390)ACC>ATC	p.T130I		NM_012240	NP_036372	Q9Y6E7	SIRT4_HUMAN	sirtuin 4	130	Deacetylase sirtuin-type.				chromatin silencing|negative regulation of insulin secretion|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTTTGAGCACCTGGGAGAAA	0.597													13	39					0	0	0.001368	0	0
MSI1	4440	broad.mit.edu	37	12	120794811	120794811	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:120794811C>T	uc001tye.1	-	9	610	c.546G>A	c.(544-546)AAG>AAA	p.K182K		NM_002442	NP_002433	O43347	MSI1H_HUMAN	musashi 1	182	RRM 2.				nervous system development	cytoplasm|nucleus	nucleotide binding			central_nervous_system(2)|breast(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGAGCTTTCTTACATTCCA	0.532											OREG0022190	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	47					0	0	0.003954	0	0
P2RX7	5027	broad.mit.edu	37	12	121605371	121605372	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:121605371_121605372CC>TT	uc001tzm.2	+	8	921_922	c.825_826CC>TT	c.(823-828)TTCCGT>TTTTGT	p.R276C	P2RX7_uc001tzn.2_Missense_Mutation_p.R186C|P2RX7_uc001tzo.2_Intron|P2RX7_uc001tzp.2_Intron|P2RX7_uc001tzq.2_Missense_Mutation_p.R106C	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	276						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AATACAGTTTCCGTCGCCTTGA	0.53													88	260					0	0	0.004672	0	0
RNF34	80196	broad.mit.edu	37	12	121867907	121867907	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:121867907G>A	uc001uam.1	+	7	1248	c.1134G>A	c.(1132-1134)AGG>AGA	p.R378R	KDM2B_uc001uaq.2_3'UTR|KDM2B_uc010szy.1_3'UTR|KDM2B_uc001uar.2_3'UTR|KDM2B_uc001uas.2_3'UTR|KDM2B_uc001uat.2_3'UTR|KDM2B_uc001uau.2_3'UTR|KDM2B_uc001uao.2_3'UTR|KDM2B_uc010szx.1_3'UTR|KDM2B_uc001uap.2_RNA	NM_025126	NP_079402	Q969K3	RNF34_HUMAN	ring finger protein 34 isoform 2	Error:Variant_position_missing_in_Q969K3_after_alignment					apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		AAGACCAAAGGAAAGTGTCGG	0.498													33	80					0	0	0.002836	0	0
IL31	386653	broad.mit.edu	37	12	122658709	122658709	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:122658709T>G	uc001ubv.2	-	1	38	c.11A>C	c.(10-12)CAC>CCC	p.H4P	LRRC43_uc001ubw.3_Intron|LRRC43_uc009zxl.1_Intron	NM_001014336	NP_001014358	Q6EBC2	IL31_HUMAN	interleukin 31 precursor	4						extracellular space	cytokine activity			central_nervous_system(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;6.93e-05)|Breast(359;0.0544)		OV - Ovarian serous cystadenocarcinoma(86;3.27e-29)|Epithelial(86;4.86e-27)|BRCA - Breast invasive adenocarcinoma(302;0.223)		GATACCTGAGTGAGAGGCCAT	0.577													10	32					0	0	0.001855	0	0
VPS33A	65082	broad.mit.edu	37	12	122750878	122750878	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:122750878G>A	uc001ucd.2	-	1	191	c.78C>T	c.(76-78)TTC>TTT	p.F26F	VPS33A_uc001ucc.2_RNA|VPS33A_uc001uce.2_Silent_p.F26F	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	26					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		ACTTGTCCAGGAACTCGCGCA	0.672													12	30					0	0	0.004007	0	0
GPR109A	338442	broad.mit.edu	37	12	123186926	123186926	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:123186926G>A	uc001ucx.1	-	1	979	c.905C>T	c.(904-906)CCC>CTC	p.P302L	GPR81_uc001ucw.1_Intron	NM_177551	NP_808219	Q8TDS4	HCAR2_HUMAN	G protein-coupled receptor 109A	302	Cytoplasmic (Potential).				negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	GAAGAAGTTGGGAAAGGATGG	0.552													12	75					0	0	0.004007	0	0
SETD8	387893	broad.mit.edu	37	12	123892187	123892187	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:123892187C>T	uc001uew.2	+	8	1038	c.996C>T	c.(994-996)CTC>CTT	p.L332L	SETD8_uc001uex.2_Silent_p.L267L	NM_020382	NP_065115	Q9NQR1	SETD8_HUMAN	SET domain-containing 8	373	SET.			L -> P (in Ref. 3; AAF97812).	cell division|mitosis|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding|transcription corepressor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.00101)|Epithelial(86;0.00425)		GGGAGGAGCTCCTGTATGACT	0.612													8	25					0	0	0.004482	0	0
DNAH10	196385	broad.mit.edu	37	12	124284800	124284801	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:124284800_124284801GG>AA	uc001uft.3	+	14	1998_1999	c.1973_1974GG>AA	c.(1972-1974)AGG>AAA	p.R658K	DNAH10_uc010tav.1_Missense_Mutation_p.R200K|DNAH10_uc010taw.1_Missense_Mutation_p.R143K	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	658	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACTTTAGAAAGGGGAGCTGTTT	0.475													10	39					0	0	0.004672	0	0
DNAH10	196385	broad.mit.edu	37	12	124298047	124298047	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:124298047G>A	uc001uft.3	+	19	3152	c.3127G>A	c.(3127-3129)GAT>AAT	p.D1043N	DNAH10_uc010tav.1_Missense_Mutation_p.D585N|DNAH10_uc010taw.1_Missense_Mutation_p.D528N	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1043	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCTAATTAAGGATGAGCATTG	0.438													13	43					0	0	0.001368	0	0
DNAH10	196385	broad.mit.edu	37	12	124377950	124377950	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:124377950G>A	uc001uft.3	+	52	8837	c.8812G>A	c.(8812-8814)GAC>AAC	p.D2938N		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2938	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCCAGTGGGGGACACCCTGAG	0.582													26	66					0	0	0.001786	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834710	125834710	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:125834710C>T	uc001uhe.1	+	2	773	c.765C>T	c.(763-765)GCC>GCT	p.A255A		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	255	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CGTTTCCAGCCCGAGAGAGGA	0.577													31	85					0	0	0.002096	0	0
RIMBP2	23504	broad.mit.edu	37	12	130927115	130927115	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:130927115C>T	uc001uil.2	-	8	895	c.731G>A	c.(730-732)GGG>GAG	p.G244E	RIMBP2_uc001uim.2_Missense_Mutation_p.G152E|RIMBP2_uc001uin.1_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	244						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CTGCTCGTTCCCCAGCGTGCT	0.597													11	41					0	0	0.000978	0	0
SFRS8	6433	broad.mit.edu	37	12	132238958	132238958	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:132238958C>T	uc001uja.1	+	9	1508	c.1368C>T	c.(1366-1368)GTC>GTT	p.V456V	SFRS8_uc010tbn.1_Silent_p.V456V|SFRS8_uc001ujb.1_Silent_p.V249V|SFRS8_uc001uiz.1_Silent_p.V330V	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	456					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		CCCCCGACGTCCAGCCCGTGA	0.602													11	30					0	0	0.008291	0	0
EP400	57634	broad.mit.edu	37	12	132471241	132471241	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:132471241C>T	uc001ujn.2	+	5	2147	c.2112C>T	c.(2110-2112)TCC>TCT	p.S704S	EP400_uc001ujl.2_Silent_p.S703S|EP400_uc001ujm.2_Silent_p.S704S|EP400_uc001ujj.1_Silent_p.S667S|EP400_uc001ujk.2_Silent_p.S740S	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	740					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CAGTCACTTCCCGGACCCCAG	0.592													38	82					0	0	0.006230	0	0
ATP8A2	51761	broad.mit.edu	37	13	26151272	26151272	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:26151272G>A	uc001uqk.2	+	20	1920	c.1778G>A	c.(1777-1779)GGG>GAG	p.G593E	ATP8A2_uc010tdi.1_Missense_Mutation_p.G553E|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.G103E	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	553	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TACTGTAAAGGGGCTGTAAGT	0.443													44	76					0	0	0.003610	0	0
FLT1	2321	broad.mit.edu	37	13	29012445	29012445	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:29012445G>A	uc001usb.3	-	4	711	c.426C>T	c.(424-426)ATC>ATT	p.I142I	FLT1_uc010aar.1_Silent_p.I142I|FLT1_uc001usc.3_Silent_p.I142I|FLT1_uc010tdp.1_Silent_p.I142I	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	142	Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TAATTTCGGGGATTTCACTGT	0.373													9	26					0	0	0.008291	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679096	37679096	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:37679096G>A	uc001uwm.1	-	1	706	c.298C>T	c.(298-300)CTC>TTC	p.L100F		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	100	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		AAATTAAAGAGGTCTTCGAGG	0.443													20	35					0	0	0.001882	0	0
TRPC4	7223	broad.mit.edu	37	13	38320211	38320211	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:38320211C>T	uc001uws.2	-	3	995	c.760G>A	c.(760-762)GAC>AAC	p.D254N	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.D254N|TRPC4_uc010tey.1_Missense_Mutation_p.D254N|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Missense_Mutation_p.D254N|TRPC4_uc010aby.2_Missense_Mutation_p.D254N	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	254	Potential.|Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TCCAGTAGGTCCTTAGCAAAT	0.413													37	56					0	0	0.005524	0	0
FREM2	341640	broad.mit.edu	37	13	39425898	39425898	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:39425898G>C	uc001uwv.2	+	11	7127	c.6818G>C	c.(6817-6819)AGA>ACA	p.R2273T	FREM2_uc001uww.2_Missense_Mutation_p.R359T	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2273	Extracellular (Potential).|Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GTGGTTATAAGAATTCCAGTG	0.443													28	21					0	0	0.007291	0	0
C13orf31	144811	broad.mit.edu	37	13	44463057	44463057	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:44463057C>T	uc010acg.2	+	5	1557	c.1072C>T	c.(1072-1074)CCT>TCT	p.P358S	C13orf31_uc001uzf.3_Missense_Mutation_p.P358S	NM_001128303	NP_001121775	Q8IV20	CM031_HUMAN	hypothetical protein LOC144811	358											0		Lung NSC(96;0.000163)|all_hematologic(4;0.0127)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Breast(139;0.0364)|Lung SC(185;0.0367)|Acute lymphoblastic leukemia(4;0.138)		GBM - Glioblastoma multiforme(144;0.000573)|BRCA - Breast invasive adenocarcinoma(63;0.121)		TAATCTTCATCCTGCATGTGT	0.403													25	53					0	0	0.005443	0	0
SPERT	220082	broad.mit.edu	37	13	46287346	46287346	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:46287346C>T	uc001van.1	+	3	266	c.186C>T	c.(184-186)CTC>CTT	p.L62L	SPERT_uc001vao.2_Silent_p.L26L	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	62						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		TCCCGAGGCTCCACAACTTGT	0.647													10	8					0	0	0.000978	0	0
ZC3H13	23091	broad.mit.edu	37	13	46544079	46544079	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:46544079A>G	uc010tfw.1	-	13	2606	c.2600T>C	c.(2599-2601)GTT>GCT	p.V867A	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Missense_Mutation_p.V867A|ZC3H13_uc001vat.1_Missense_Mutation_p.V867A	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	867							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		AGGTCGTACAACTTGGCTCAA	0.408													30	47					0	0	0.007291	0	0
HNRNPA1L2	144983	broad.mit.edu	37	13	53217246	53217246	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:53217246G>A	uc001vgx.1	+	7	1692	c.619G>A	c.(619-621)GGA>AGA	p.G207R	HNRNPA1L2_uc001vgy.1_Missense_Mutation_p.G207R|HNRNPA1L2_uc001vgz.1_Missense_Mutation_p.G207R	NM_001011724	NP_001011724	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like	207	Gly-rich.				mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding				0						tggtggtcgtggagatggttt	0.209													11	19					0	0	0.001368	0	0
PCDH17	27253	broad.mit.edu	37	13	58207511	58207511	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:58207511A>G	uc001vhq.1	+	1	1723	c.831A>G	c.(829-831)GAA>GAG	p.E277E	PCDH17_uc010aec.1_Silent_p.E277E	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	277	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCAATGGTGAAGTGCTCTACT	0.592													20	31					0	0	0.007413	0	0
PCDH9	5101	broad.mit.edu	37	13	66878807	66878807	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:66878807G>T	uc001vik.2	-	5	4386	c.3694C>A	c.(3694-3696)CCT>ACT	p.P1232T	PCDH9_uc010aei.2_RNA|PCDH9_uc001vil.2_Missense_Mutation_p.P1198T|PCDH9_uc010thl.1_Missense_Mutation_p.P1190T	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	1232	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TGCTCCTTAGGACTCTCAGTA	0.423													17	31					5.3912e-06	8.19053e-06	0.006122	1	0
LMO7	4008	broad.mit.edu	37	13	76415295	76415295	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:76415295C>T	uc001vjv.2	+	20	3694	c.2934C>T	c.(2932-2934)GCC>GCT	p.A978A	LMO7_uc010thv.1_Silent_p.A929A|LMO7_uc001vjt.1_Silent_p.A877A|LMO7_uc010thw.1_Silent_p.A855A|LMO7_uc001vjw.1_Silent_p.A884A	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1263						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GGCAAAGGGCCAAACAGGAGG	0.378													18	32					0	0	0.002299	0	0
MYCBP2	23077	broad.mit.edu	37	13	77817289	77817289	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:77817289G>A	uc001vkf.2	-	18	2511	c.2420C>T	c.(2419-2421)CCA>CTA	p.P807L	MYCBP2_uc010aev.2_Missense_Mutation_p.P211L	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	807					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CCCGGGCACTGGGACAGCTAG	0.383													17	27					0	0	0.006122	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328746	88328746	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:88328746C>T	uc001vln.2	+	2	1322	c.1103C>T	c.(1102-1104)TCC>TTC	p.S368F	SLITRK5_uc010tic.1_Missense_Mutation_p.S127F	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	368	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CAGACCAAATCCCCGGTGCCT	0.597													22	12					0	0	0.003330	0	0
DOCK9	23348	broad.mit.edu	37	13	99575589	99575589	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:99575589G>A	uc001vnt.2	-	5	511	c.456C>T	c.(454-456)GTC>GTT	p.V152V	DOCK9_uc001vnw.2_Silent_p.V151V|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.V152V|DOCK9_uc010tis.1_Silent_p.V151V|DOCK9_uc010tit.1_Silent_p.V152V|DOCK9_uc010afu.1_5'UTR	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	152					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAACTTCATAGACATGAACTG	0.373													31	71					0	0	0.005524	0	0
NALCN	259232	broad.mit.edu	37	13	101890118	101890118	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:101890118G>A	uc001vox.1	-	12	1611	c.1422C>T	c.(1420-1422)TTC>TTT	p.F474F	NALCN_uc001voy.2_Silent_p.F189F|NALCN_uc001voz.2_Silent_p.F474F|NALCN_uc001vpa.2_Silent_p.F474F	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	474	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GAAAGTACGTGAATTGTGAAT	0.303													87	113					0	0	0.003610	0	0
MYO16	23026	broad.mit.edu	37	13	109707909	109707909	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:109707909C>T	uc001vqt.1	+	27	3361	c.3235C>T	c.(3235-3237)CCT>TCT	p.P1079S	MYO16_uc010agk.1_Missense_Mutation_p.P1101S|MYO16_uc001vqu.1_Missense_Mutation_p.P879S|MYO16_uc010tjh.1_Missense_Mutation_p.P591S	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1079	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ATATGGATACCCTGTTCGCCT	0.433													41	61					0	0	0.003610	0	0
COL4A2	1284	broad.mit.edu	37	13	111111269	111111269	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:111111269C>T	uc001vqx.2	+	22	1873	c.1584C>T	c.(1582-1584)TTC>TTT	p.F528F		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	528	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			TCCCTGGGTTCCCAGGGCTCA	0.597													4	2					0	0	0.000248	0	0
ARHGEF7	8874	broad.mit.edu	37	13	111857668	111857668	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:111857668G>A	uc001vrs.2	+	4	598	c.348G>A	c.(346-348)CAG>CAA	p.Q116Q	ARHGEF7_uc001vrr.2_Silent_p.Q95Q|ARHGEF7_uc001vrt.2_Silent_p.Q66Q|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_5'UTR|ARHGEF7_uc001vrv.3_Intron|ARHGEF7_uc001vrw.3_5'UTR|ARHGEF7_uc001vrx.3_5'UTR|ARHGEF7_uc010tjo.1_Silent_p.Q13Q	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	116	CH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			ATCAGGGGCAGAATTTTAACA	0.388													23	32					0	0	0.004656	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113208409	113208409	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:113208409G>A	uc001vse.1	-	8	1115	c.928C>T	c.(928-930)CAG>TAG	p.Q310*	TUBGCP3_uc010tjq.1_Nonsense_Mutation_p.Q300*|TUBGCP3_uc001vsf.2_Nonsense_Mutation_p.Q310*|TUBGCP3_uc001vsg.1_Nonsense_Mutation_p.Q310*	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	310					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					AGGCTCCTCTGGTCCGTGTAT	0.483													23	48					0	0	0.003330	0	0
OR4N5	390437	broad.mit.edu	37	14	20612129	20612129	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:20612129C>T	uc010tla.1	+	1	235	c.235C>T	c.(235-237)CCC>TCC	p.P79S		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	79	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		CATTGTGGTTCCCAGGATGTT	0.478													69	83					0	0	0.003610	0	0
DCAF11	80344	broad.mit.edu	37	14	24590046	24590046	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:24590046G>A	uc001wlv.2	+	12	1373	c.1093_splice	c.e12-1	p.G365_splice	DCAF11_uc001wlw.2_Splice_Site_p.G365_splice|DCAF11_uc001wlz.2_Splice_Site_p.G265_splice|DCAF11_uc001wly.2_Splice_Site_p.G321_splice|DCAF11_uc001wme.2_Splice_Site_p.G325_splice|DCAF11_uc010tny.1_Splice_Site_p.G232_splice|DCAF11_uc001wmd.2_Splice_Site_p.G365_splice|DCAF11_uc001wmc.2_Splice_Site_p.G265_splice|DCAF11_uc001wmb.3_Splice_Site_p.G339_splice|DCAF11_uc001wma.3_Splice_Site_p.G365_splice	NM_001163484	NP_001156956	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11 isoform 1							CUL4 RING ubiquitin ligase complex	protein binding				0						TGGATTCATAGGGTGATGCCC	0.517													51	71					0	0	0.003610	0	0
TGM1	7051	broad.mit.edu	37	14	24728447	24728447	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:24728447G>A	uc001wod.2	-	7	1117	c.993C>T	c.(991-993)TCC>TCT	p.S331S	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	331			S -> P (in ARCI-TGM1).		cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TGTCATCCAGGGAGTTCACCT	0.622													4	6					0	0	0.000248	0	0
RIPK3	11035	broad.mit.edu	37	14	24808511	24808511	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:24808511C>T	uc001wpb.2	-	3	391	c.181G>A	c.(181-183)GTC>ATC	p.V61I	RIPK3_uc001wpa.2_5'Flank|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_5'UTR|RIPK3_uc010toj.1_Missense_Mutation_p.V61I	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	61	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		ATGGCCTTGACCTCCCTGGAT	0.582													30	38					0	0	0.002445	0	0
SCFD1	23256	broad.mit.edu	37	14	31144256	31144256	+	Silent	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:31144256T>G	uc001wqm.1	+	14	1251	c.1227T>G	c.(1225-1227)GTT>GTG	p.V409V	SCFD1_uc001wqn.1_Silent_p.V342V|SCFD1_uc010tpg.1_Silent_p.V350V|SCFD1_uc010tph.1_Silent_p.V224V|SCFD1_uc010amf.1_Silent_p.V224V|SCFD1_uc010tpi.1_Silent_p.V317V|SCFD1_uc010amd.1_Silent_p.V241V|SCFD1_uc010ame.1_Silent_p.V342V	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	409					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		CCACTGCTGTTTTAGAACATA	0.229													25	27					0	0	0.008361	0	0
AKAP6	9472	broad.mit.edu	37	14	33147646	33147646	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:33147646C>T	uc001wrq.2	+	8	3030	c.2860C>T	c.(2860-2862)CAT>TAT	p.H954Y	AKAP6_uc010aml.2_Missense_Mutation_p.H951Y	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	954					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GTCAAAAGTTCATTCAGTGGG	0.408													17	28					0	0	0.007413	0	0
SRP54	6729	broad.mit.edu	37	14	35482571	35482571	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:35482571A>T	uc001wso.2	+	9	1007	c.656A>T	c.(655-657)TAT>TTT	p.Y219F	SRP54_uc010tpp.1_Missense_Mutation_p.Y170F|SRP54_uc010tpq.1_Missense_Mutation_p.Y155F	NM_003136	NP_003127	P61011	SRP54_HUMAN	signal recognition particle 54kDa isoform 1	219	G-domain.				GTP catabolic process|response to drug|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane, translocation	cytosol|nuclear speck|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|drug binding|endoplasmic reticulum signal peptide binding|GDP binding|GTP binding|nucleoside-triphosphatase activity|ribonucleoprotein binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;2.48e-05)|Lung(238;3.13e-05)|Epithelial(34;0.0314)|all cancers(34;0.0797)|BRCA - Breast invasive adenocarcinoma(188;0.243)	GBM - Glioblastoma multiforme(112;0.0396)		AACATTGTTTATGTGATGGAT	0.348													18	29					0	0	0.002780	0	0
FSCB	84075	broad.mit.edu	37	14	44974376	44974376	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:44974376C>T	uc001wvn.2	-	1	2124	c.1815G>A	c.(1813-1815)GAG>GAA	p.E605E		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	605	Ala-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CAGCAGGAGCCTCTTCTGCAG	0.597													12	13					0	0	0.001368	0	0
DDHD1	80821	broad.mit.edu	37	14	53539314	53539314	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:53539314C>T	uc001xai.2	-	6	1733	c.1503_splice	c.e6+1	p.E501_splice	DDHD1_uc001xaj.2_Splice_Site_p.E508_splice|DDHD1_uc001xah.2_Splice_Site_p.E501_splice|DDHD1_uc001xag.2_Splice_Site_p.E83_splice	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c						lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					ATGACACTTACTTCATCTCTA	0.318													13	21					0	0	0.001368	0	0
DDHD1	80821	broad.mit.edu	37	14	53558541	53558541	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:53558541C>T	uc001xai.2	-	4	1481	c.1251G>A	c.(1249-1251)CAG>CAA	p.Q417Q	DDHD1_uc001xaj.2_Silent_p.Q424Q|DDHD1_uc001xah.2_Silent_p.Q417Q|DDHD1_uc001xag.2_5'UTR	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	417					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					GGTCCATTTTCTGCCCAATGC	0.373													27	42					0	0	0.002096	0	0
C14orf101	54916	broad.mit.edu	37	14	57099831	57099832	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:57099831_57099832CC>TT	uc001xcm.2	+	13	1788_1789	c.1666_1667CC>TT	c.(1666-1668)CCT>TTT	p.P556F	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_Missense_Mutation_p.P89F|C14orf101_uc001xco.2_Missense_Mutation_p.P89F	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	556						integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		TGTATTCAACCCTGAGGAATGG	0.381													13	32					0	0	0.004672	0	0
OTX2	5015	broad.mit.edu	37	14	57270960	57270960	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:57270960G>A	uc001xcp.2	-	2	366	c.195C>T	c.(193-195)ATC>ATT	p.I65I	OTX2_uc010aou.2_Silent_p.I65I|OTX2_uc001xcq.2_Silent_p.I73I	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	65	Homeobox.				axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					CTCGCATGAAGATGTCTGGGT	0.597													11	20					0	0	0.001368	0	0
SYT16	83851	broad.mit.edu	37	14	62536400	62536400	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:62536400C>T	uc001xfu.1	+	2	800	c.603C>T	c.(601-603)TCC>TCT	p.S201S	SYT16_uc010tsd.1_Silent_p.S201S	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	201										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TTGAGATTTCCGTGTCCCGGT	0.483													40	47					0	0	0.002522	0	0
SYNE2	23224	broad.mit.edu	37	14	64519208	64519208	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:64519208C>T	uc001xgm.2	+	48	8807	c.8577C>T	c.(8575-8577)CCC>CCT	p.P2859P	SYNE2_uc001xgl.2_Silent_p.P2859P	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2859	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGATAATTCCCAGGGTGGAGA	0.378													28	34					0	0	0.007291	0	0
MTHFD1	4522	broad.mit.edu	37	14	64896942	64896942	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:64896942G>A	uc001xhb.2	+	13	1692	c.1305G>A	c.(1303-1305)ATG>ATA	p.M435I	MTHFD1_uc010aqe.2_Missense_Mutation_p.M471I|MTHFD1_uc010aqf.2_Missense_Mutation_p.M491I	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	435	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TCATTCCTATGGAAGAGGTAA	0.483											OREG0022729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	61	65					0	0	0.003610	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68044831	68044831	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:68044831T>C	uc001xjl.1	+	19	2808	c.2666T>C	c.(2665-2667)GTT>GCT	p.V889A	PLEKHH1_uc010tsw.1_Missense_Mutation_p.V457A|PLEKHH1_uc001xjn.1_Missense_Mutation_p.V404A|PLEKHH1_uc010tsx.1_5'Flank	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	889	MyTH4.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		GTCTGCCTGGTTCACCCCGAG	0.617													22	35					0	0	0.002299	0	0
ACTN1	87	broad.mit.edu	37	14	69341640	69341640	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:69341640G>A	uc001xkl.2	-	21	2925	c.2615C>T	c.(2614-2616)TCC>TTC	p.S872F	ACTN1_uc001xkk.2_Missense_Mutation_p.S468F|ACTN1_uc010ttb.1_Missense_Mutation_p.S802F|ACTN1_uc001xkm.2_Missense_Mutation_p.S894F|ACTN1_uc001xkn.2_Missense_Mutation_p.S867F	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	872					focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		ACCTGGCACGGAGTCGGGGCC	0.662													18	19					0	0	0.008871	0	0
GALNTL1	57452	broad.mit.edu	37	14	69800304	69800304	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:69800304G>A	uc010aqu.1	+	9	1047	c.954G>A	c.(952-954)GGG>GGA	p.G318G	GALNTL1_uc001xla.1_Silent_p.G318G|GALNTL1_uc001xlb.1_Silent_p.G318G	NM_020692	NP_065743	Q8N428	GLTL1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	318	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)		ACATCTGGGGGGGAGAGAATT	0.363													25	29					0	0	0.007291	0	0
KIAA0247	9766	broad.mit.edu	37	14	70170167	70170167	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:70170167C>T	uc001xlk.2	+	3	493	c.177C>T	c.(175-177)CCC>CCT	p.P59P	KIAA0247_uc010aqz.2_Silent_p.P34P	NM_014734	NP_055549	Q92537	K0247_HUMAN	hypothetical protein LOC9766 precursor	59	Sushi.|Extracellular (Potential).					integral to membrane				ovary(3)	3				all cancers(60;0.00155)|BRCA - Breast invasive adenocarcinoma(234;0.0164)|OV - Ovarian serous cystadenocarcinoma(108;0.0196)		ACCCCCGGCCCTGCAGAGACC	0.567													22	29					0	0	0.001882	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72176192	72176192	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:72176192C>T	uc001xms.2	+	15	4430	c.4082C>T	c.(4081-4083)CCC>CTC	p.P1361L	SIPA1L1_uc001xmt.2_Missense_Mutation_p.P1340L|SIPA1L1_uc001xmu.2_Missense_Mutation_p.P1340L|SIPA1L1_uc001xmv.2_Missense_Mutation_p.P1361L|SIPA1L1_uc010ttm.1_Missense_Mutation_p.P815L|SIPA1L1_uc001xmw.2_Missense_Mutation_p.P126L	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1361	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AAAGTGGCACCCCTATGGCAC	0.592													15	23					0	0	0.003163	0	0
DCAF4	26094	broad.mit.edu	37	14	73420935	73420935	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:73420935C>T	uc001xng.2	+	10	1092	c.872C>T	c.(871-873)TCC>TTC	p.S291F	DCAF4_uc001xnj.2_Missense_Mutation_p.S292F|DCAF4_uc010ttr.1_Missense_Mutation_p.S270F|DCAF4_uc001xnh.2_Missense_Mutation_p.S191F|DCAF4_uc010tts.1_Missense_Mutation_p.S231F|DCAF4_uc010ttt.1_Missense_Mutation_p.S77F|DCAF4_uc001xni.2_Intron|DCAF4_uc001xnk.2_Missense_Mutation_p.S291F	NM_015604	NP_056419	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4 isoform 1	291						CUL4 RING ubiquitin ligase complex		p.S291T(1)		ovary(1)|central_nervous_system(1)|skin(1)	3						TGTGCCTGGTCCCTGAATATC	0.547													68	102					0	0	0.003610	0	0
ACOT4	122970	broad.mit.edu	37	14	74062021	74062021	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:74062021C>T	uc001xoo.2	+	3	1183	c.929C>T	c.(928-930)CCA>CTA	p.P310L		NM_152331	NP_689544	Q8N9L9	ACOT4_HUMAN	acyl-CoA thioesterase 4	310					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)		AGCATGATTCCAATAGAGAAG	0.493													17	29					0	0	0.004007	0	0
DNAL1	83544	broad.mit.edu	37	14	74125555	74125555	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:74125555G>A	uc001xoq.3	+	3	213	c.48G>A	c.(46-48)GAG>GAA	p.E16E	DNAL1_uc010aru.2_5'UTR|DNAL1_uc010arv.2_Intron	NM_031427	NP_113615	Q4LDG9	DNAL1_HUMAN	axonemal dynein light chain 1	16											0				BRCA - Breast invasive adenocarcinoma(234;0.00384)|KIRC - Kidney renal clear cell carcinoma(182;0.095)		CATAGGAAGAGAAAACTGGCC	0.393													44	69					0	0	0.008740	0	0
KIAA0317	9870	broad.mit.edu	37	14	75136688	75136688	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:75136688A>T	uc001xqb.2	-	14	2255	c.1750T>A	c.(1750-1752)TTC>ATC	p.F584I	KIAA0317_uc010tut.1_Missense_Mutation_p.F423I	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	584	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		TGGGCCAGGAAAGAGCGGGTG	0.517													23	29					0	0	0.002780	0	0
BATF	10538	broad.mit.edu	37	14	76012946	76012946	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:76012946C>T	uc001xrr.2	+	3	552	c.310C>T	c.(310-312)CCC>TCC	p.P104S		NM_006399	NP_006390	Q16520	BATF_HUMAN	basic leucine zipper transcription factor,	104						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.028)		GCCCTCGCCCCCCGAGGTGGT	0.652													5	8					0	0	0.001168	0	0
FLVCR2	55640	broad.mit.edu	37	14	76107327	76107327	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:76107327G>A	uc001xrs.2	+	7	1641	c.1265G>A	c.(1264-1266)GGA>GAA	p.G422E	FLVCR2_uc010tvd.1_Missense_Mutation_p.G217E	NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	422	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		CTCCCACTGGGATTTGAGTTT	0.502													30	40					0	0	0.003755	0	0
STON2	85439	broad.mit.edu	37	14	81744729	81744729	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:81744729C>T	uc010tvu.1	-	4	1127	c.926G>A	c.(925-927)TGG>TAG	p.W309*	STON2_uc001xvk.1_Nonsense_Mutation_p.W309*|STON2_uc010tvt.1_Nonsense_Mutation_p.W106*	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	309					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GGTTGCCCTCCAAGGTGAAGC	0.512													36	49					0	0	0.003755	0	0
STON2	85439	broad.mit.edu	37	14	81837529	81837529	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:81837529G>A	uc010tvu.1	-	3	575	c.374C>T	c.(373-375)GCC>GTC	p.A125V	STON2_uc001xvk.1_Missense_Mutation_p.A125V	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	125					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		CAATGGTAGGGCTGGGGAGAG	0.448													22	39					0	0	0.001523	0	0
FLRT2	23768	broad.mit.edu	37	14	86088580	86088580	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:86088580C>T	uc001xvr.2	+	2	1489	c.722C>T	c.(721-723)TCG>TTG	p.S241L	FLRT2_uc010atd.2_Missense_Mutation_p.S241L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	241	Extracellular (Potential).|LRR 8.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GTACGTAATTCGCTGTCCCAC	0.502													28	32					0	0	0.004656	0	0
FLRT2	23768	broad.mit.edu	37	14	86089130	86089130	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:86089130G>A	uc001xvr.2	+	2	2039	c.1272G>A	c.(1270-1272)CGG>CGA	p.R424R	FLRT2_uc010atd.2_Silent_p.R424R	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	424	Fibronectin type-III.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TTTCTGAACGGATCCAGCTCT	0.483													12	22					0	0	0.001368	0	0
EML5	161436	broad.mit.edu	37	14	89131692	89131692	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:89131692C>T	uc001xxg.2	-	23	3452	c.3266G>A	c.(3265-3267)CGA>CAA	p.R1089Q	EML5_uc001xxf.2_5'UTR|EML5_uc001xxh.1_Missense_Mutation_p.R228Q	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1089	WD 18.					cytoplasm|microtubule				ovary(3)	3						AGGTGAAAATCGAATATCTGA	0.343													8	11					0	0	0.003080	0	0
TTC8	123016	broad.mit.edu	37	14	89307837	89307837	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:89307837C>T	uc010ath.2	+	5	662	c.528C>T	c.(526-528)TCC>TCT	p.S176S	TTC8_uc010atg.1_RNA|TTC8_uc001xxl.2_Intron|TTC8_uc010ati.2_5'UTR|TTC8_uc001xxm.2_Intron|TTC8_uc010atj.2_Intron|TTC8_uc001xxi.2_Silent_p.S186S|TTC8_uc001xxj.2_Silent_p.S176S|TTC8_uc001xxk.2_Intron	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	186					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						CAAAGTATTCCCAGAAACCTA	0.308									Bardet-Biedl_syndrome				21	43					0	0	0.002299	0	0
TTC7B	145567	broad.mit.edu	37	14	91007723	91007723	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:91007723G>A	uc001xyp.2	-	20	2643	c.2521C>T	c.(2521-2523)CGC>TGC	p.R841C	TTC7B_uc001xyo.2_Missense_Mutation_p.R285C|TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	841							binding			ovary(2)	2		Melanoma(154;0.222)				CAGAGCACGCGGGGGATGATG	0.687													4	5					0	0	0.000248	0	0
CATSPERB	79820	broad.mit.edu	37	14	92076893	92076893	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:92076893G>A	uc001xzs.1	-	21	2669	c.2529C>T	c.(2527-2529)ATC>ATT	p.I843I	CATSPERB_uc010aub.1_Silent_p.I365I	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	843					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				CTTCAAATGGGATAAATTTGC	0.378													26	35					0	0	0.004656	0	0
KIAA1409	57578	broad.mit.edu	37	14	94063734	94063734	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:94063734C>T	uc001ybv.1	+	21	2772	c.2689C>T	c.(2689-2691)CTG>TTG	p.L897L	KIAA1409_uc001ybs.1_Silent_p.L897L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1074						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TTGTAGATTTCTGGATATTCA	0.438													15	32					0	0	0.004990	0	0
SERPINA3	12	broad.mit.edu	37	14	95081190	95081190	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:95081190G>A	uc001ydp.2	+	2	491	c.412G>A	c.(412-414)GGA>AGA	p.G138R	SERPINA3_uc001ydo.3_Missense_Mutation_p.G163R|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.G138R|SERPINA3_uc001yds.2_Missense_Mutation_p.G138R|SERPINA3_uc010avg.2_Missense_Mutation_p.G138R	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	138					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		GCTGAGTATGGGAAATGCCAT	0.537													8	17					0	0	0.003080	0	0
DICER1	23405	broad.mit.edu	37	14	95570308	95570308	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:95570308G>A	uc001ydw.2	-	22	3607	c.3425C>T	c.(3424-3426)TCT>TTT	p.S1142F	DICER1_uc010avh.1_Missense_Mutation_p.S40F|DICER1_uc001ydv.2_Missense_Mutation_p.S1132F|DICER1_uc001ydx.2_Missense_Mutation_p.S1142F|DICER1_uc001ydy.1_5'UTR	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1142					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		ATTTTCTAGAGAGGAGGTTCT	0.423			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				16	23					0	0	0.003163	0	0
BDKRB2	624	broad.mit.edu	37	14	96707723	96707723	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:96707723A>C	uc010avm.1	+	3	1254	c.1058A>C	c.(1057-1059)AAA>ACA	p.K353T	BDKRB2_uc010avl.1_3'UTR|BDKRB2_uc010twu.1_Missense_Mutation_p.K326T|BDKRB2_uc001yfg.2_Missense_Mutation_p.K353T	NM_000623	NP_000614	P30411	BKRB2_HUMAN	bradykinin receptor B2	353	Cytoplasmic (Potential).				arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			ovary(3)|breast(1)|kidney(1)	5		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		GTGTGCCAGAAAGGGGGCTGC	0.572													8	26					0	0	0.008291	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103433413	103433413	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:103433413C>T	uc001ymi.1	-	17	2673	c.2441G>A	c.(2440-2442)TGG>TAG	p.W814*	CDC42BPB_uc001ymj.1_5'Flank	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	814	Potential.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CTGAGCTTCCCAGTGGGCCAC	0.562													22	21					0	0	0.003330	0	0
INF2	64423	broad.mit.edu	37	14	105174858	105174858	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:105174858C>T	uc001ypb.2	+	9	1964	c.1821C>T	c.(1819-1821)TCC>TCT	p.S607S	INF2_uc010tyi.1_Silent_p.S607S|INF2_uc001ypc.2_Silent_p.S607S|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	607	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		GACTATTCTCCTTCCCTGCAG	0.687											OREG0022959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	13					0	0	0.003163	0	0
AHNAK2	113146	broad.mit.edu	37	14	105420984	105420984	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:105420984C>T	uc010axc.1	-	7	924	c.804G>A	c.(802-804)AAG>AAA	p.K268K	AHNAK2_uc001ypx.2_Silent_p.K168K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	268						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCGCTTGCTCTTTATGGATT	0.582													9	12					0	0	0.000978	0	0
ADAM6	8755	broad.mit.edu	37	14	106406010	106406010	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:106406010C>T	uc010tyt.1	-	2357		c.42137G>A								Parts of antibodies, mostly variable regions.												0						ACACTGACCCCATGGGAGGCC	0.557													13	11					0	0	0.001855	0	0
ADAM6	8755	broad.mit.edu	37	14	106780979	106780979	+	RNA	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:106780979G>A	uc010tyt.1	-	412		c.14965C>T								Parts of antibodies, mostly variable regions.												0						CTCTCAGAAAGTATTTCCCAT	0.507													4	8					0	0	0.003080	0	0
ADAM6	8755	broad.mit.edu	37	14	107083655	107083655	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:107083655C>T	uc010tyt.1	-	112		c.5219G>A								Parts of antibodies, mostly variable regions.												0						GGAGCTGCCACCAGGAGAAGG	0.517													11	18					0	0	0.000978	0	0
LOC646214	646214	broad.mit.edu	37	15	21937740	21937740	+	RNA	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:21937740G>A	uc010tzj.1	-	1		c.3000C>T				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						TCACTGTGTTGGAGTCGTAGA	0.488													14	41					0	0	0.001855	0	0
MKRN3	7681	broad.mit.edu	37	15	23811821	23811821	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:23811821G>A	uc001ywh.3	+	1	1368	c.892G>A	c.(892-894)GAA>AAA	p.E298K	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.E298K	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	298						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GAAAGATATGGAACTCTCGTT	0.537													4	21					0	0	0.000248	0	0
OTUD7A	161725	broad.mit.edu	37	15	31819489	31819489	+	Silent	SNP	C	T	T	rs142018701		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:31819489C>T	uc001zfq.2	-	5	768	c.675G>A	c.(673-675)CGG>CGA	p.R225R	OTUD7A_uc001zfr.2_Silent_p.R225R	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	225	OTU.|Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		ACACCAGGTCCCGGTCGTGAA	0.557													15	35					0	0	0.004007	0	0
CHRM5	1133	broad.mit.edu	37	15	34356426	34356426	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:34356426G>A	uc001zhk.1	+	3	2178	c.1508G>A	c.(1507-1509)AGG>AAG	p.R503K	CHRM5_uc001zhl.1_Missense_Mutation_p.R503K	NM_012125	NP_036257	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	503	Cytoplasmic (By similarity).				cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	AGAACCTTCAGGAAGACCTTT	0.483													27	10					0	0	0.007291	0	0
THBS1	7057	broad.mit.edu	37	15	39885722	39885722	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:39885722G>A	uc001zkh.2	+	19	3299	c.3120G>A	c.(3118-3120)TGG>TGA	p.W1040*	THBS1_uc010bbi.2_Nonsense_Mutation_p.W512*	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	1040	TSP C-terminal.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TTGTGATGTGGAAGCAAGTCA	0.532													33	43					0	0	0.002836	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42276730	42276730	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:42276730C>T	uc001zow.1	-	18	2203	c.2203G>A	c.(2203-2205)GAA>AAA	p.E735K	PLA2G4E_uc010udc.1_Missense_Mutation_p.E207K|PLA2G4E_uc001zov.1_Missense_Mutation_p.E388K	NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	752	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		AGGTAGCATTCCTTGAGATTT	0.502													12	21					0	0	0.002450	0	0
TGM7	116179	broad.mit.edu	37	15	43574782	43574782	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:43574782C>T	uc001zrf.1	-	8	1046	c.1041G>A	c.(1039-1041)CGG>CGA	p.R347R		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	347					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GGAGATCTTTCCGGATCATCC	0.488													6	3					0	0	0.003080	0	0
STRC	161497	broad.mit.edu	37	15	43893725	43893725	+	Missense_Mutation	SNP	G	A	A	rs147990592		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:43893725G>A	uc001zsf.2	-	24	4648	c.4570C>T	c.(4570-4572)CGT>TGT	p.R1524C	STRC_uc010bdl.2_Missense_Mutation_p.R751C|STRC_uc001zse.2_Missense_Mutation_p.R42C	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1524					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TGCTCAGGACGAAATCCCCGG	0.398													17	21					0	0	0.006122	0	0
CKMT1A	548596	broad.mit.edu	37	15	43990946	43990946	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:43990946C>T	uc001zsn.2	+	9	1511	c.1119C>T	c.(1117-1119)GAC>GAT	p.D373D	CKMT1A_uc010uea.1_Silent_p.D404D|CKMT1A_uc001zso.3_Silent_p.D373D	NM_001015001	NP_001015001	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1A precursor	373	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	CTAATTTGGACCGACTAGGCA	0.507													42	55					0	0	0.003610	0	0
DUOX2	50506	broad.mit.edu	37	15	45394107	45394107	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:45394107C>T	uc010bea.2	-	21	2938	c.2735G>A	c.(2734-2736)GGA>GAA	p.G912E	DUOX2_uc001zun.2_Missense_Mutation_p.G912E	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	912	EF-hand 3.|Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		GTCCTGGAATCCCGACTCCCG	0.572													15	21					0	0	0.004990	0	0
FBN1	2200	broad.mit.edu	37	15	48748863	48748863	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:48748863A>C	uc001zwx.1	-	44	5721	c.5393T>G	c.(5392-5394)TTC>TGC	p.F1798C	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1798	EGF-like 29; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GTCATTATAGAAGAATCCCAC	0.438													30	51					0	0	0.001786	0	0
SPPL2A	84888	broad.mit.edu	37	15	51040393	51040393	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:51040393G>A	uc001zyv.2	-	4	547	c.367C>T	c.(367-369)CCC>TCC	p.P123S		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	signal peptide peptidase-like 2A	123	Cytoplasmic (Potential).|PA.					integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		TTACCTGAGGGAGGAAACTAA	0.249													5	6					0	0	0.000602	0	0
PRTG	283659	broad.mit.edu	37	15	55921201	55921201	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:55921201C>T	uc002adg.2	-	16	2673	c.2625G>A	c.(2623-2625)GGG>GGA	p.G875G		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	875	Fibronectin type-III 5.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TGGTTATTGCCCCTAGAAATA	0.308													10	16					0	0	0.008291	0	0
GCNT3	9245	broad.mit.edu	37	15	59911093	59911093	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:59911093C>T	uc002age.2	+	3	1105	c.656C>T	c.(655-657)CCG>CTG	p.P219L	GCNT3_uc002agd.2_Missense_Mutation_p.P219L	NM_004751	NP_004742	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin	219	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)	2						AGCTCAGTGCCGTGGAAATAC	0.502													42	55					0	0	0.002222	0	0
VPS13C	54832	broad.mit.edu	37	15	62217696	62217696	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:62217696T>C	uc002agz.2	-	53	6642	c.6568A>G	c.(6568-6570)AAG>GAG	p.K2190E	VPS13C_uc002aha.2_Missense_Mutation_p.K2147E|VPS13C_uc002ahb.1_Missense_Mutation_p.K2190E|VPS13C_uc002ahc.1_Missense_Mutation_p.K2147E	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2190					protein localization					ovary(2)	2						ATATTTTGCTTTCCTGAAGCC	0.284													3	5					0	0	0.004672	0	0
VPS13C	54832	broad.mit.edu	37	15	62217698	62217698	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:62217698C>T	uc002agz.2	-	53	6640	c.6566G>A	c.(6565-6567)GGA>GAA	p.G2189E	VPS13C_uc002aha.2_Missense_Mutation_p.G2146E|VPS13C_uc002ahb.1_Missense_Mutation_p.G2189E|VPS13C_uc002ahc.1_Missense_Mutation_p.G2146E	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2189					protein localization					ovary(2)	2						ATTTTGCTTTCCTGAAGCCCA	0.284													3	6					0	0	0.004672	0	0
FBXL22	283807	broad.mit.edu	37	15	63893549	63893549	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:63893549G>A	uc002amn.2	+	2	404	c.390G>A	c.(388-390)GGG>GGA	p.G130G	uc002amj.2_5'Flank|uc002amk.2_5'Flank|uc002aml.2_5'Flank	NM_203373	NP_976307	Q6P050	FXL22_HUMAN	F-box and leucine-rich repeat protein 22	130											0						CGTCCTCGGGGACTCCGATCG	0.687													13	18					0	0	0.001368	0	0
IGDCC4	57722	broad.mit.edu	37	15	65676382	65676382	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:65676382C>T	uc002aou.1	-	20	3928	c.3718G>A	c.(3718-3720)GGC>AGC	p.G1240S	IGDCC4_uc002aot.1_Missense_Mutation_p.G828S	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	1240	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						CTGGGCAGGCCTGGGCTGGCT	0.622													10	24					0	0	0.002450	0	0
SLC24A1	9187	broad.mit.edu	37	15	65917849	65917849	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:65917849C>T	uc010ujf.1	+	2	1718	c.1431C>T	c.(1429-1431)TTC>TTT	p.F477F	SLC24A1_uc010ujd.1_Silent_p.F477F|SLC24A1_uc010uje.1_Silent_p.F477F|SLC24A1_uc010ujg.1_Silent_p.F477F|SLC24A1_uc010ujh.1_Silent_p.F477F	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	477	Cytoplasmic (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						ACGAGTACTTCGTTCCAGCCC	0.572													41	40					0	0	0.007835	0	0
SPESP1	246777	broad.mit.edu	37	15	69223036	69223036	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:69223036C>T	uc002arn.1	+	1	172	c.44C>T	c.(43-45)TCG>TTG	p.S15L	NOX5_uc002arp.1_5'UTR|NOX5_uc002arq.1_5'UTR|NOX5_uc010bid.1_Silent_p.F3F|NOX5_uc002aro.2_RNA	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	15					multicellular organismal development	acrosomal vesicle					0						CTATGGCCTTCGTCTGTGCCG	0.642													32	43					0	0	0.006230	0	0
SCAMP5	192683	broad.mit.edu	37	15	75310222	75310222	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:75310222C>T	uc002azk.1	+	5	467	c.305C>T	c.(304-306)TCC>TTC	p.S102F	SCAMP5_uc002azl.1_Missense_Mutation_p.S102F|SCAMP5_uc002azm.1_Missense_Mutation_p.S102F|SCAMP5_uc002azn.1_Missense_Mutation_p.S102F|SCAMP5_uc010uly.1_Missense_Mutation_p.S31F	NM_138967	NP_620417	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	102	Cytoplasmic (Potential).				exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						ACTGACAGCTCCTTCAGTTTC	0.592													24	49					0	0	0.004656	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75562480	75562480	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:75562480C>T	uc002azs.1	+	18	2063	c.1986C>T	c.(1984-1986)CCC>CCT	p.P662P	uc002azu.1_5'Flank|uc010ulz.1_5'Flank	NM_001145224	NP_001138696	A6NDK9	GOG6C_HUMAN	golgi autoantigen, golgin subfamily a, 6D	674										ovary(1)	1						AGGGTTCTCCCCATGACAACC	0.602													21	81					0	0	0.001523	0	0
SH2D7	646892	broad.mit.edu	37	15	78393523	78393523	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:78393523G>A	uc010blb.1	+	5	928	c.928G>A	c.(928-930)GAG>AAG	p.E310K		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	310											0						GGGTCCCACAGAGTCTCCCAC	0.612													5	9					0	0	0.000602	0	0
IL16	3603	broad.mit.edu	37	15	81600992	81600992	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:81600992C>T	uc002bgh.3	+	19	4228	c.3852C>T	c.(3850-3852)ATC>ATT	p.I1284I	IL16_uc002bge.3_RNA|IL16_uc010unp.1_Silent_p.I1325I|IL16_uc002bgg.2_Silent_p.I1283I|IL16_uc002bgj.2_Silent_p.I777I|IL16_uc002bgk.2_Silent_p.I583I	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	1284	PDZ 4.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GAGATGAAATCTTACAGCTGG	0.517													24	34					0	0	0.005443	0	0
AP3B2	8120	broad.mit.edu	37	15	83345327	83345327	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:83345327C>T	uc010uoh.1	-	14	1728	c.1551G>A	c.(1549-1551)AGG>AGA	p.R517R	AP3B2_uc010uoi.1_Silent_p.R517R|AP3B2_uc010uoj.1_Silent_p.R485R|AP3B2_uc010uog.1_Silent_p.R153R	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	517					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			CAGGTGCAATCCTGGGGACAT	0.527													24	14					0	0	0.003954	0	0
ALPK3	57538	broad.mit.edu	37	15	85400209	85400209	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:85400209C>T	uc002ble.2	+	6	3013	c.2846C>T	c.(2845-2847)CCT>CTT	p.P949L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	949					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ACAGCGGGTCCTAGAGCTCCT	0.557													33	43					0	0	0.003271	0	0
AGBL1	123624	broad.mit.edu	37	15	86807597	86807597	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:86807597G>A	uc002blz.1	+	10	1137	c.1057G>A	c.(1057-1059)GAC>AAC	p.D353N	AGBL1_uc002bma.1_Missense_Mutation_p.D84N|AGBL1_uc002bmb.1_Missense_Mutation_p.D47N	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	353					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						CTACAGCAAGGACCAAAGCTC	0.493													5	7					0	0	0.001168	0	0
AEN	64782	broad.mit.edu	37	15	89169881	89169881	+	Silent	SNP	C	T	T	rs35195058	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:89169881C>T	uc002bmt.2	+	2	592	c.441C>T	c.(439-441)ATC>ATT	p.I147I	AEN_uc010bnl.2_Silent_p.I147I|AEN_uc010bnm.1_Silent_p.I147I	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	147	Exonuclease.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						ACAAGTACATCAGGCCTGAGA	0.607													29	32					0	0	0.006320	0	0
ACAN	176	broad.mit.edu	37	15	89398703	89398703	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:89398703C>T	uc010upo.1	+	12	3261	c.2887C>T	c.(2887-2889)CTA>TTA	p.L963L	ACAN_uc010upp.1_Silent_p.L963L|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	963					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGGAGAAGTTCTAGAGACCTC	0.567													28	45					0	0	0.005443	0	0
ANPEP	290	broad.mit.edu	37	15	90328675	90328675	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:90328675G>A	uc002bop.3	-	21	3101	c.2809C>T	c.(2809-2811)CTG>TTG	p.L937L		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	937	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GCTTGCTCCAGGGCCCGGGTG	0.542													35	61					0	0	0.006999	0	0
NGRN	51335	broad.mit.edu	37	15	90814640	90814640	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:90814640G>A	uc002bpf.1	+	3	546	c.496G>A	c.(496-498)GGC>AGC	p.G166S	TTLL13_uc002bpe.1_RNA|NGRN_uc002bpg.1_Missense_Mutation_p.G94S	NM_001033088	NP_001028260	Q9NPE2	NGRN_HUMAN	neugrin	166					neuron differentiation	extracellular region|nucleus				large_intestine(2)|ovary(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			GCTCCCTGCAGGCCACTCTGT	0.512													21	33					0	0	0.002780	0	0
PRC1	9055	broad.mit.edu	37	15	91512731	91512732	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:91512731_91512732GG>AA	uc002bqm.2	-	13	1851_1852	c.1694_1695CC>TT	c.(1693-1695)CCC>CTT	p.P565L	PRC1_uc002bqn.2_Missense_Mutation_p.P565L|PRC1_uc002bqo.2_Intron|PRC1_uc010uqs.1_Intron	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	565	Unstructured, Arg/Lys rich.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					TGCGCTGGAGGGGGGCCGAGCC	0.54													155	251					0	0	0.004672	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92459306	92459306	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:92459306G>A	uc002bqx.2	+	2	465	c.264G>A	c.(262-264)GGG>GGA	p.G88G	SLCO3A1_uc002bqy.2_Silent_p.G88G|SLCO3A1_uc010boc.1_RNA|SLCO3A1_uc002bqz.1_Silent_p.G30G	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	88	Helical; Name=2; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			TCGAGATCGGGAACCTGGCGC	0.672													18	24					0	0	0.008871	0	0
IGF1R	3480	broad.mit.edu	37	15	99500576	99500576	+	Missense_Mutation	SNP	C	T	T	rs141802822	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:99500576C>T	uc002bul.2	+	21	4059	c.4009C>T	c.(4009-4011)CGC>TGC	p.R1337C	IGF1R_uc010bon.2_Missense_Mutation_p.R1336C	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	1337	Cytoplasmic (Potential).				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GCTGGTCCTCCGCGCCAGCTT	0.687													11	15					0	0	0.000978	0	0
AXIN1	8312	broad.mit.edu	37	16	360064	360064	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:360064C>T	uc002cgp.1	-	4	1202	c.1025G>A	c.(1024-1026)GGG>GAG	p.G342E	AXIN1_uc002cgq.1_Missense_Mutation_p.G342E	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	342					activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				TGGGGGGATCCCATCCCTGTC	0.627													7	5					0	0	0.004482	0	0
TPSAB1	7177	broad.mit.edu	37	16	1291250	1291250	+	Missense_Mutation	SNP	C	T	T	rs17841226	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:1291250C>T	uc002ckz.2	+	3	210	c.158C>T	c.(157-159)CCA>CTA	p.P53L	TPSAB1_uc010uux.1_5'UTR	NM_003294	NP_003285	Q15661	TRYB1_HUMAN	tryptase alpha/beta 1 precursor	53	Peptidase S1.				defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GTCCACGGCCCATACTGGATG	0.711													18	24					0	0	0.001523	0	0
TSC2	7249	broad.mit.edu	37	16	2131601	2131601	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2131601A>G	uc002con.2	+	31	3722	c.3616A>G	c.(3616-3618)ACC>GCC	p.T1206A	TSC2_uc010bsd.2_Missense_Mutation_p.T1206A|TSC2_uc002coo.2_Missense_Mutation_p.T1162A|TSC2_uc010uvv.1_Missense_Mutation_p.T1126A|TSC2_uc010uvw.1_Missense_Mutation_p.T1114A|TSC2_uc002cop.2_Missense_Mutation_p.T962A|TSC2_uc002coq.2_5'Flank|TSC2_uc002cor.2_5'Flank	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1206					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CGCAGGGAACACCAGCTGGCT	0.647			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				25	44					0	0	0.003954	0	0
PGP	283871	broad.mit.edu	37	16	2263819	2263819	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2263819A>C	uc002cpk.1	-	2	920	c.876T>G	c.(874-876)AAT>AAG	p.N292K	C16orf79_uc002cpi.1_5'Flank|C16orf79_uc010bsh.2_5'Flank|PGP_uc010uvz.1_RNA	NM_001042371	NP_001035830	A6NDG6	PGP_HUMAN	phosphoglycolate phosphatase	292					carbohydrate metabolic process		phosphoglycolate phosphatase activity			skin(1)	1						CACTTTCCTGATTATTCTTCA	0.517													19	62					0	0	0.007413	0	0
E4F1	1877	broad.mit.edu	37	16	2284186	2284186	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2284186G>C	uc002cpm.2	+	10	1438	c.1390G>C	c.(1390-1392)GCC>CCC	p.A464P	E4F1_uc010bsi.2_Missense_Mutation_p.A464P|E4F1_uc010bsj.2_Intron|DNASE1L2_uc002cpn.2_5'Flank|DNASE1L2_uc002cpo.2_5'Flank|DNASE1L2_uc002cpp.2_5'Flank|DNASE1L2_uc002cpq.2_5'Flank	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	464	Mediates interaction with CDKN2A.|C2H2-type 5.|Interaction with BMI1.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GAGGCCGTTCGCCTGCGCGCA	0.706													10	18					0	0	0.008291	0	0
AMDHD2	51005	broad.mit.edu	37	16	2578376	2578376	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2578376C>T	uc002cqq.2	+	7	954	c.857C>T	c.(856-858)CCC>CTC	p.P286L	AMDHD2_uc002cqp.2_Missense_Mutation_p.P286L|AMDHD2_uc010uwc.1_Missense_Mutation_p.P286L|AMDHD2_uc010uwd.1_Missense_Mutation_p.P50L	NM_015944	NP_057028	Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2 isoform 1	286					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			skin(2)|large_intestine(1)|breast(1)	4						CGTGCCCATCCCCAGGGTAAG	0.662													19	24					0	0	0.001882	0	0
KCTD5	54442	broad.mit.edu	37	16	2749829	2749829	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2749829T>G	uc002crd.2	+	4	516	c.461T>G	c.(460-462)GTG>GGG	p.V154G		NM_018992	NP_061865	Q9NXV2	KCTD5_HUMAN	potassium channel tetramerisation domain	154					interspecies interaction between organisms	cytosol|nucleus|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity				0						CAGGTGCCTGTGAAGCATGTG	0.647													26	26					0	0	0.001786	0	0
SRRM2	23524	broad.mit.edu	37	16	2817499	2817499	+	Missense_Mutation	SNP	C	T	T	rs61747731		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2817499C>T	uc002crk.2	+	11	7519	c.6970C>T	c.(6970-6972)CCC>TCC	p.P2324S	SRRM2_uc002crj.1_Missense_Mutation_p.P2228S|SRRM2_uc002crl.1_Missense_Mutation_p.P2324S|SRRM2_uc010bsu.1_Missense_Mutation_p.P2228S	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2324	Ala-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TGCAAACTATCCCTCCAGCTC	0.602													65	84					0	0	0.003610	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3140185	3140185	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:3140185G>A	uc002ctv.1	-	5	1173	c.1085C>T	c.(1084-1086)TCG>TTG	p.S362L	ZSCAN10_uc002cty.1_Missense_Mutation_p.S23L|ZSCAN10_uc002ctw.1_Missense_Mutation_p.S280L|ZSCAN10_uc002ctx.1_Missense_Mutation_p.S290L	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	362	C2H2-type 3.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GCTCAGGTGCGAGCTCTGGCG	0.692													19	34					0	0	0.001523	0	0
ZNF205	7755	broad.mit.edu	37	16	3166463	3166463	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:3166463C>T	uc002cub.2	+	5	534	c.399C>T	c.(397-399)CTC>CTT	p.L133L	MGC3771_uc010bte.2_5'Flank|MGC3771_uc002ctz.3_5'Flank|ZNF205_uc002cua.2_Silent_p.L133L	NM_001042428	NP_001035893	O95201	ZN205_HUMAN	zinc finger protein 205	133	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						CCTTGTACCTCTCCCGGGAGG	0.562													17	23					0	0	0.008871	0	0
DNASE1	1773	broad.mit.edu	37	16	3705913	3705913	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:3705913G>A	uc002cvr.2	+	3	2318	c.211G>A	c.(211-213)GGG>AGG	p.G71R		NM_005223	NP_005214	P24855	DNAS1_HUMAN	deoxyribonuclease I precursor	71					apoptosis|DNA catabolic process	extracellular region|nuclear envelope	actin binding|deoxyribonuclease I activity				0		Ovarian(90;0.0261)		Kidney(780;0.0556)	Dornase Alfa(DB00003)	GACTGCCGTGGGGAAGCTGCT	0.622								Direct_reversal_of_damage					22	25					0	0	0.005443	0	0
CREBBP	1387	broad.mit.edu	37	16	3777962	3777962	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:3777962G>A	uc002cvv.2	-	31	7290	c.7086C>T	c.(7084-7086)AGC>AGT	p.S2362S	CREBBP_uc002cvw.2_Silent_p.S2324S	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	2362					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGGTGACGGGCTGGAATGTG	0.652			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				26	42					0	0	0.002445	0	0
MGRN1	23295	broad.mit.edu	37	16	4701967	4701967	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:4701967C>T	uc002cwz.2	+	3	347	c.211C>T	c.(211-213)CCC>TCC	p.P71S	MGRN1_uc002cxa.2_Missense_Mutation_p.P71S|MGRN1_uc010btx.2_Missense_Mutation_p.P71S|MGRN1_uc010btw.2_Missense_Mutation_p.P71S|MGRN1_uc002cxb.2_Missense_Mutation_p.P71S|MGRN1_uc010uxo.1_Missense_Mutation_p.P71S|MGRN1_uc010uxp.1_Missense_Mutation_p.P71S|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	71					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						CTCCTAGTTTCCCTACGTCAC	0.612													13	40					0	0	0.004990	0	0
MGRN1	23295	broad.mit.edu	37	16	4731613	4731613	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:4731613C>T	uc002cwz.2	+	13	1330	c.1194C>T	c.(1192-1194)CTC>CTT	p.L398L	MGRN1_uc002cxa.2_Silent_p.L398L|MGRN1_uc010btx.2_Silent_p.L377L|MGRN1_uc010btw.2_Silent_p.L377L|MGRN1_uc002cxb.2_Silent_p.L437L|MGRN1_uc010uxo.1_Silent_p.L376L|MGRN1_uc010uxp.1_Silent_p.L376L|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	398					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						TCAACGGCCTCCGGGCTGTCT	0.657													18	23					0	0	0.001882	0	0
UBN1	29855	broad.mit.edu	37	16	4926972	4926972	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:4926972C>T	uc002cyb.2	+	16	3464	c.3125C>T	c.(3124-3126)TCC>TTC	p.S1042F	UBN1_uc010uxw.1_Missense_Mutation_p.S1042F|UBN1_uc002cyc.2_Missense_Mutation_p.S1042F	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	1042	Ser-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						AGCTCGAACTCCTTGGGAATT	0.562													40	75					0	0	0.003214	0	0
PPL	5493	broad.mit.edu	37	16	4941922	4941922	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:4941922T>G	uc002cyd.1	-	16	1948	c.1858A>C	c.(1858-1860)AGC>CGC	p.S620R		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	620	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TGCTGCAGGCTCTTCTCCAGG	0.627													34	50					0	0	0.004289	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858655	9858655	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:9858655C>T	uc002czo.3	-	13	3294	c.2746G>A	c.(2746-2748)GAC>AAC	p.D916N	GRIN2A_uc010uym.1_Missense_Mutation_p.D916N|GRIN2A_uc010uyn.1_Missense_Mutation_p.D759N|GRIN2A_uc002czr.3_Missense_Mutation_p.D916N	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	916	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGGGTGAGTCCATTCTTGAG	0.458													58	85					0	0	0.003610	0	0
RUNDC2A	84127	broad.mit.edu	37	16	12096892	12096892	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:12096892C>T	uc002dbw.1	+	3	176	c.114C>T	c.(112-114)TCC>TCT	p.S38S		NM_032167	NP_115543	Q9HA26	RUN2A_HUMAN	RUN domain containing 2A	38	RUN.									ovary(1)	1						CCTCGGATTCCGACAGCAGGT	0.512			T	CIITA	PMBL|Hodgkin Lymphona|								24	37					0	0	0.001786	0	0
MKL2	57496	broad.mit.edu	37	16	14345761	14345761	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:14345761C>T	uc010uza.1	+	14	2601	c.2446C>T	c.(2446-2448)CAG>TAG	p.Q816*	MKL2_uc002dcg.2_Nonsense_Mutation_p.Q766*|MKL2_uc002dcj.2_Nonsense_Mutation_p.Q61*	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	805					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						TCTTCCATATCAGAGACATCC	0.403													28	41					0	0	0.002096	0	0
ACSM1	116285	broad.mit.edu	37	16	20702372	20702372	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:20702372C>T	uc002dhm.1	-	1	207	c.139G>A	c.(139-141)GAG>AAG	p.E47K	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Missense_Mutation_p.E47K	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	47					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						TTAAATTCCTCCGGTACTTCA	0.488													36	56					0	0	0.004289	0	0
DNAH3	55567	broad.mit.edu	37	16	20975684	20975684	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:20975684G>A	uc010vbe.1	-	53	9522	c.9522C>T	c.(9520-9522)ACC>ACT	p.T3174T	DNAH3_uc010vbd.1_Silent_p.T609T	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3174	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCCTCAAACGGGTTGTGATGT	0.453													31	50					0	0	0.008361	0	0
DNAH3	55567	broad.mit.edu	37	16	21071604	21071604	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:21071604C>T	uc010vbe.1	-	26	3794	c.3794G>A	c.(3793-3795)GGG>GAG	p.G1265E		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1265	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TGCTTCAATCCCAAGTCCAAT	0.502													46	73					0	0	0.003610	0	0
CRYM	1428	broad.mit.edu	37	16	21272580	21272580	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:21272580G>A	uc002dik.2	-	7	960	c.875C>T	c.(874-876)TCT>TTT	p.S292F	CRYM_uc010bwq.1_RNA|CRYM_uc002dil.2_Missense_Mutation_p.S250F|CRYM_uc002dim.2_Missense_Mutation_p.S292F	NM_001888	NP_001879	Q14894	CRYM_HUMAN	crystallin, mu isoform 1	292					negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity				0				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)	CTTACCCAAAGACTTGAACAC	0.512													8	10					0	0	0.003080	0	0
SCNN1G	6340	broad.mit.edu	37	16	23203737	23203737	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:23203737A>C	uc002dlm.1	+	4	822	c.683A>C	c.(682-684)GAG>GCG	p.E228A		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	228	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	GCCATTCAGGAGTGGTATAAG	0.502													36	48					0	0	0.004878	0	0
PRKCB	5579	broad.mit.edu	37	16	24104231	24104231	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:24104231T>C	uc002dmd.2	+	6	846	c.649T>C	c.(649-651)TGC>CGC	p.C217R	PRKCB_uc002dme.2_Missense_Mutation_p.C217R	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	217	C2.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	AACCATCAAATGCTCCCTCAA	0.468													23	30					0	0	0.003330	0	0
GTF3C1	2975	broad.mit.edu	37	16	27475829	27475830	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:27475829_27475830GG>AA	uc002dov.1	-	34	5723_5724	c.5683_5684CC>TT	c.(5683-5685)CCC>TTC	p.P1895F	GTF3C1_uc002dou.2_Missense_Mutation_p.P1895F	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1895						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CCCAAGGCTGGGGGCCAAATTT	0.668													29	69					0	0	0.004672	0	0
GTF3C1	2975	broad.mit.edu	37	16	27476005	27476006	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:27476005_27476006GG>AA	uc002dov.1	-	34	5547_5548	c.5507_5508CC>TT	c.(5506-5508)CCC>CTT	p.P1836L	GTF3C1_uc002dou.2_Missense_Mutation_p.P1836L	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1836						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						ACCCCTCCAGGGGTCTGGCCTG	0.673													16	52					0	0	0.004672	0	0
GTF3C1	2975	broad.mit.edu	37	16	27481569	27481569	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:27481569G>A	uc002dov.1	-	31	4714	c.4674C>T	c.(4672-4674)GCC>GCT	p.A1558A	GTF3C1_uc002dou.2_Silent_p.A1558A	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1558						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CCAGTGAAAAGGCCACCATGT	0.537													38	99					0	0	0.003755	0	0
KIAA0556	23247	broad.mit.edu	37	16	27720122	27720122	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:27720122A>C	uc002dow.2	+	13	1510	c.1486A>C	c.(1486-1488)ACA>CCA	p.T496P	KIAA0556_uc002dox.1_Missense_Mutation_p.T404P	NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	496										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						GGTGGGTCTCACAGAAGTCGA	0.537													15	56					0	0	0.004990	0	0
TBX6	6911	broad.mit.edu	37	16	30102231	30102231	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30102231G>A	uc010veh.1	-	3	261	c.201C>T	c.(199-201)CCC>CCT	p.P67P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TBX6_uc002dwk.1_Silent_p.P67P	NM_004608	NP_004599	O95947	TBX6_HUMAN	T-box 6	67					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GGGGCAGAAGGGGCAGAGGTG	0.667													11	18					0	0	0.000978	0	0
ZNF48	197407	broad.mit.edu	37	16	30410152	30410153	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30410152_30410153CC>TT	uc002dya.1	+	2	1640_1641	c.1581_1582CC>TT	c.(1579-1584)GCCCCT>GCTTCT	p.P528S	ZNF48_uc002dxz.1_Missense_Mutation_p.P405S	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	528	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACCCATGGCCCCTCGACCCCG	0.658													22	26					0	0	0.004672	0	0
ITGAL	3683	broad.mit.edu	37	16	30516721	30516721	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30516721G>A	uc002dyi.3	+	20	2480	c.2304G>A	c.(2302-2304)GAG>GAA	p.E768E	ITGAL_uc002dyj.3_Silent_p.E684E|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	768	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	TCCCTTTTGAGAAGAACTGTG	0.542													30	53					0	0	0.002445	0	0
ITGAL	3683	broad.mit.edu	37	16	30516772	30516772	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30516772C>T	uc002dyi.3	+	20	2531	c.2355C>T	c.(2353-2355)TTC>TTT	p.F785F	ITGAL_uc002dyj.3_Silent_p.F701F|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	785	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GAGTGTCCTTCTCTCCTGCAA	0.433													21	46					0	0	0.001523	0	0
RNF40	9810	broad.mit.edu	37	16	30777704	30777704	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30777704C>T	uc002dzq.2	+	10	1241	c.1118C>T	c.(1117-1119)GCC>GTC	p.A373V	RNF40_uc010caa.2_Missense_Mutation_p.A373V|RNF40_uc010cab.2_Intron|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Missense_Mutation_p.A373V|RNF40_uc010vfb.1_Intron|RNF40_uc010vfc.1_5'Flank	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	373	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			CCCCAGGTGGCCCTGCGGAGC	0.617													28	38					0	0	0.003271	0	0
ITGAX	3687	broad.mit.edu	37	16	31373954	31373954	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:31373954C>T	uc002ebu.1	+	12	1306	c.1239C>T	c.(1237-1239)CTC>CTT	p.L413L	ITGAX_uc002ebt.2_Silent_p.L413L|ITGAX_uc010vfk.1_Silent_p.L63L	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	413	FG-GAP 4.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGCTGGCCCTCTGGAAAGGGG	0.672													3	7					0	0	0.004672	0	0
DNAJA2	10294	broad.mit.edu	37	16	47001558	47001558	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:47001558G>A	uc002eeo.2	-	5	586	c.444C>T	c.(442-444)GGC>GGT	p.G148G	DNAJA2_uc002eep.2_Silent_p.G65G	NM_005880	NP_005871	O60884	DNJA2_HUMAN	DnaJ subfamily A member 2	148	CR-type.|CXXCXGXG motif.				positive regulation of cell proliferation|protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			lung(1)	1		all_cancers(37;0.00125)|all_lung(18;0.00338)|all_epithelial(9;0.00358)|Lung NSC(13;0.0309)|Breast(268;0.116)				TTCCGCCTTGGCTAAAGCAAG	0.468													40	39					0	0	0.003610	0	0
ADCY7	113	broad.mit.edu	37	16	50339720	50339721	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:50339720_50339721CC>TT	uc002egd.1	+	13	1980_1981	c.1712_1713CC>TT	c.(1711-1713)ACC>ATT	p.T571I	ADCY7_uc002egc.1_Missense_Mutation_p.T571I	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	571	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	GACTTCTACACCTTTGGGTCCA	0.668													14	23					0	0	0.004672	0	0
CES7	221223	broad.mit.edu	37	16	55886881	55886881	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:55886881G>A	uc002eip.2	-	10	1334	c.1185C>T	c.(1183-1185)TCC>TCT	p.S395S	CES7_uc002eio.2_Silent_p.S395S|CES7_uc002eiq.2_Silent_p.S156S|CES7_uc002eir.2_Silent_p.S289S	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	395						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		TTTCAGTCAGGGAGTGCTTGT	0.473													25	31					0	0	0.006320	0	0
HERPUD1	9709	broad.mit.edu	37	16	56973251	56973251	+	Silent	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:56973251A>T	uc002eke.1	+	5	943	c.534A>T	c.(532-534)GCA>GCT	p.A178A	HERPUD1_uc002ekf.1_Silent_p.A177A|HERPUD1_uc002ekg.1_Silent_p.A153A|HERPUD1_uc010cco.1_Silent_p.A239A|HERPUD1_uc010ccp.1_Intron|HERPUD1_uc002ekh.1_5'UTR	NM_014685	NP_055500	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum	178	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0						AGATATATGCACGACAGTACT	0.527			T	ERG	prostate								48	114					0	0	0.003610	0	0
GPR97	222487	broad.mit.edu	37	16	57719662	57719662	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:57719662G>A	uc002emh.2	+	11	1467	c.1364G>A	c.(1363-1365)TGG>TAG	p.W455*	GPR97_uc010vhv.1_Nonsense_Mutation_p.W335*|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_Nonsense_Mutation_p.W63*	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	455	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						CTGGTGGTCTGGAAGATCTTC	0.597													14	25					0	0	0.001855	0	0
MMP15	4324	broad.mit.edu	37	16	58078993	58078993	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:58078993C>T	uc002ena.2	+	10	2626	c.1653C>T	c.(1651-1653)TCC>TCT	p.S551S		NM_002428	NP_002419	P51511	MMP15_HUMAN	matrix metalloproteinase 15 preproprotein	551	Hemopexin-like 4.|Extracellular (Potential).				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			central_nervous_system(2)|breast(1)	3						ACCCCAAGTCCATCCTGCGGG	0.657													5	14					0	0	0.000602	0	0
NAE1	8883	broad.mit.edu	37	16	66844305	66844305	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:66844305G>A	uc002eqf.2	-	15	1199	c.1122C>T	c.(1120-1122)TCC>TCT	p.S374S	NAE1_uc002eqe.2_Silent_p.S368S|NAE1_uc002eqg.2_Silent_p.S285S|NAE1_uc010cdv.2_Silent_p.S377S	NM_003905	NP_003896	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform a	374					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TCTCTGAAATGGACTCTGGTG	0.378													33	63					0	0	0.006230	0	0
PDP2	57546	broad.mit.edu	37	16	66918222	66918222	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:66918222C>T	uc002eqk.1	+	2	197	c.35C>T	c.(34-36)TCT>TTT	p.S12F		NM_020786	NP_065837	Q9P2J9	PDP2_HUMAN	pyruvate dehydrogenase phosphatase isoenzyme 2	12					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		ATCTTAAATTCTACAAGGAAC	0.373													42	191					0	0	0.002522	0	0
CDH16	1014	broad.mit.edu	37	16	66948315	66948315	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:66948315C>T	uc002eql.2	-	7	657	c.584G>A	c.(583-585)GGG>GAG	p.G195E	CDH16_uc010cdy.2_Missense_Mutation_p.G195E|CDH16_uc002eqm.2_Intron	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	195	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GCTGGTGCTCCCTAGAACAGG	0.602													12	25					0	0	0.001368	0	0
FHOD1	29109	broad.mit.edu	37	16	67281298	67281298	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:67281298C>T	uc002esl.2	-	1	128	c.16G>A	c.(16-18)GAC>AAC	p.D6N	FHOD1_uc010ced.2_5'UTR|FHOD1_uc010vjh.1_5'UTR|SLC9A5_uc002esm.2_5'Flank|SLC9A5_uc010cee.2_5'Flank|SLC9A5_uc010vji.1_5'Flank	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	6					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TCCCCGCGGTCTTCCCCGCCC	0.677													7	12					0	0	0.001984	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67322240	67322240	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:67322240C>T	uc002eso.3	+	19	5926	c.3391C>T	c.(3391-3393)CCC>TCC	p.P1131S	PLEKHG4_uc002esp.3_Missense_Mutation_p.P938S|PLEKHG4_uc002esq.3_Missense_Mutation_p.P1131S|PLEKHG4_uc010cef.2_Missense_Mutation_p.P1131S|PLEKHG4_uc002ess.3_Missense_Mutation_p.P1131S|PLEKHG4_uc010ceg.2_Missense_Mutation_p.P1050S	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	1131					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		TCCCCTGTATCCCAGCTTCCC	0.627													25	56					0	0	0.003330	0	0
FAM65A	79567	broad.mit.edu	37	16	67578895	67578895	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:67578895C>T	uc010vjp.1	+	17	3062	c.2966C>T	c.(2965-2967)ACC>ATC	p.T989I	FAM65A_uc002eth.2_Missense_Mutation_p.T969I|FAM65A_uc010cej.2_Missense_Mutation_p.T972I|FAM65A_uc010vjq.1_Missense_Mutation_p.T983I|FAM65A_uc002etk.2_Missense_Mutation_p.T967I	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	973						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		GGCTTCCTGACCTTCTGGGAC	0.617													45	136					0	0	0.002852	0	0
RLTPR	146206	broad.mit.edu	37	16	67685394	67685394	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:67685394G>A	uc002etn.2	+	24	2524	c.2404G>A	c.(2404-2406)GAG>AAG	p.E802K	RLTPR_uc010cel.1_Missense_Mutation_p.E795K|RLTPR_uc010vjr.1_Missense_Mutation_p.E766K|RLTPR_uc010vjs.1_5'Flank	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	802										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		ACAGGTGGGCGAGGTCTGCCG	0.562													4	8					0	0	0.000248	0	0
CDH1	999	broad.mit.edu	37	16	68847364	68847364	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:68847364C>T	uc002ewg.1	+	9	1410	c.1286C>T	c.(1285-1287)CCA>CTA	p.P429L	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Intron	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	429	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.Y380_K440del(5)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		ACCACAAATCCAGTGAACAAC	0.473			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				52	165					0	0	0.003610	0	0
HAS3	3038	broad.mit.edu	37	16	69143862	69143862	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:69143862G>A	uc010cfh.2	+	2	788	c.564G>A	c.(562-564)CAG>CAA	p.Q188Q	HAS3_uc002ewk.2_Silent_p.Q188Q|HAS3_uc010vlk.1_Silent_p.Q188Q|HAS3_uc002ewl.2_Silent_p.Q188Q	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	188	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		GCATCATGCAGAAGTGGGGAG	0.642													13	25					0	0	0.001855	0	0
SNTB2	6645	broad.mit.edu	37	16	69334793	69334793	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:69334793C>T	uc002ewu.2	+	7	1609	c.1589C>T	c.(1588-1590)TCG>TTG	p.S530L	SNTB2_uc010cfk.2_5'Flank	NM_006750	NP_006741	Q13425	SNTB2_HUMAN	basic beta 2 syntrophin	530	Calmodulin-binding (By similarity).|SU.					cell junction|dystrophin-associated glycoprotein complex|membrane fraction|microtubule|transport vesicle membrane	actin binding|calmodulin binding|protein binding				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.208)		ACGTTTTTATCGGCCAAAGTC	0.418													22	50					0	0	0.001882	0	0
AARS	16	broad.mit.edu	37	16	70286801	70286801	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:70286801G>A	uc002eyn.1	-	21	2840	c.2730C>T	c.(2728-2730)GCC>GCT	p.A910A	EXOSC6_uc002eym.1_5'Flank|AARS_uc010vlu.1_Silent_p.A756A	NM_001605	NP_001596	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	910					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			pancreas(1)	1		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	AGCCCCGATTGGCTGCATTCT	0.557											OREG0023912	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	42					0	0	0.008871	0	0
HYDIN	54768	broad.mit.edu	37	16	70998635	70998635	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:70998635C>T	uc002ezr.2	-	37	5909	c.5781G>A	c.(5779-5781)GAG>GAA	p.E1927E		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1928	Potential.									ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TCTCACCATTCTCCTGTGCCA	0.433													7	18					0	0	0.000978	0	0
PHLPP2	23035	broad.mit.edu	37	16	71701153	71701153	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:71701153G>A	uc002fax.2	-	11	1718	c.1712C>T	c.(1711-1713)CCC>CTC	p.P571L	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Missense_Mutation_p.P571L	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	571	LRR 15.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						CACCTCGAGGGGGATGTGCTC	0.473													27	52					0	0	0.004656	0	0
PHLPP2	23035	broad.mit.edu	37	16	71736601	71736601	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:71736601G>A	uc002fax.2	-	2	324	c.318C>T	c.(316-318)ATC>ATT	p.I106I	PHLPP2_uc010cgf.2_Silent_p.I106I|PHLPP2_uc002fay.1_Silent_p.I106I	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	106						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						AATCATAAACGATCTGAAGAG	0.363													20	46					0	0	0.003330	0	0
ZNF821	55565	broad.mit.edu	37	16	71895750	71895750	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:71895750G>A	uc010vmj.1	-	6	889	c.513C>T	c.(511-513)ATC>ATT	p.I171I	ATXN1L_uc010vmi.1_Intron|ZNF821_uc002fbe.2_Silent_p.I21I|ZNF821_uc002fbf.2_Silent_p.I129I|ZNF821_uc002fbg.3_Silent_p.I21I|ZNF821_uc002fbh.3_Silent_p.I129I|ZNF821_uc002fbi.3_Intron	NM_017530	NP_060000	O75541	ZN821_HUMAN	zinc finger protein 821	171	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E171Q(1)		ovary(1)	1						CCTCCGAGTGGATTAAGAGGT	0.582													25	58					0	0	0.003954	0	0
PMFBP1	83449	broad.mit.edu	37	16	72170368	72170368	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:72170368C>T	uc002fcc.3	-	9	1354	c.1182G>A	c.(1180-1182)AAG>AAA	p.K394K	PMFBP1_uc002fcd.2_Silent_p.K394K|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Silent_p.K249K	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	394	Potential.							p.K394Q(1)		ovary(2)	2		Ovarian(137;0.179)				TCAAAGTGAGCTTTTGGGTCT	0.547													28	74					0	0	0.007291	0	0
FA2H	79152	broad.mit.edu	37	16	74752957	74752958	+	Missense_Mutation	DNP	GG	AC	AC			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:74752957_74752958GG>AC	uc002fde.1	-	5	782_783	c.714_715CC>GT	c.(712-717)TTCCAC>TTGTAC	p.238_239FH>LY	FA2H_uc002fdd.1_5'Flank|FA2H_uc010vmy.1_RNA	NM_024306	NP_077282	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	238_239					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity				0						GGCTTCATGTGGAACAGGAAGC	0.614													16	40					0	0	0.004672	0	0
VAT1L	57687	broad.mit.edu	37	16	78005799	78005799	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:78005799T>A	uc002ffg.1	+	8	1227	c.1130T>A	c.(1129-1131)ATT>AAT	p.I377N		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	377							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						GGCAAGTTAATTCTGGATGTA	0.527											OREG0023950	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	69	152					0	0	0.003610	0	0
BCMO1	53630	broad.mit.edu	37	16	81293407	81293407	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:81293407C>T	uc002fgn.1	+	3	538	c.320C>T	c.(319-321)TCC>TTC	p.S107F	BCMO1_uc002fgm.1_Missense_Mutation_p.S107F|BCMO1_uc010vnp.1_Intron	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	107					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						AACATATTTTCCAAGTAACTG	0.408													25	64					0	0	0.004656	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033037	82033037	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:82033037G>A	uc002fgu.2	-	3	989	c.861C>T	c.(859-861)GTC>GTT	p.V287V		NM_145168	NP_660151	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E,	287	Helical; (Potential).				steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding				0						CAAAGCAGTAGACCAAGGTCA	0.507													18	39					0	0	0.007413	0	0
CDH13	1012	broad.mit.edu	37	16	83711929	83711929	+	Silent	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:83711929T>G	uc002fgx.2	+	10	1521	c.1401T>G	c.(1399-1401)ACT>ACG	p.T467T	CDH13_uc010vns.1_Silent_p.T514T|CDH13_uc010vnt.1_Silent_p.T213T|CDH13_uc010vnu.1_Silent_p.T428T	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	467	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TCCACATCACTGTCCTGGATG	0.582													18	54					0	0	0.008871	0	0
SLC38A8	146167	broad.mit.edu	37	16	84063101	84063101	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:84063101G>A	uc002fhg.1	-	5	688	c.688C>T	c.(688-690)CAG>TAG	p.Q230*		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	230	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0						AAAATTACCTGAAACCCGAAG	0.522													7	29					0	0	0.001984	0	0
KIAA0513	9764	broad.mit.edu	37	16	85111229	85111229	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:85111229G>A	uc002fiu.2	+	6	993	c.773G>A	c.(772-774)AGG>AAG	p.R258K	KIAA0513_uc002fis.3_Missense_Mutation_p.R258K|KIAA0513_uc010voj.1_Missense_Mutation_p.R258K|KIAA0513_uc002fit.2_Missense_Mutation_p.R258K	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	258						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		CCCCTGGCCAGGAGGAACGAG	0.672													13	31					0	0	0.001855	0	0
KIAA0182	23199	broad.mit.edu	37	16	85694852	85694852	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:85694852C>G	uc002fix.2	+	9	1815	c.1741C>G	c.(1741-1743)CCC>GCC	p.P581A	KIAA0182_uc002fiw.2_Missense_Mutation_p.P477A|KIAA0182_uc002fiy.2_Missense_Mutation_p.P508A|KIAA0182_uc002fiz.2_5'Flank|KIAA0182_uc010cho.2_5'Flank	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	581	Pro-rich.						protein binding			large_intestine(3)|ovary(1)|skin(1)	5						CCATGCTGCACCCACGGCCCT	0.662													25	46					0	0	0.003954	0	0
KIAA0182	23199	broad.mit.edu	37	16	85694854	85694854	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:85694854C>T	uc002fix.2	+	9	1817	c.1743C>T	c.(1741-1743)CCC>CCT	p.P581P	KIAA0182_uc002fiw.2_Silent_p.P477P|KIAA0182_uc002fiy.2_Silent_p.P508P|KIAA0182_uc002fiz.2_5'Flank|KIAA0182_uc010cho.2_5'Flank	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	581	Pro-rich.						protein binding			large_intestine(3)|ovary(1)|skin(1)	5						ATGCTGCACCCACGGCCCTCT	0.657													23	45					0	0	0.002780	0	0
MVD	4597	broad.mit.edu	37	16	88719738	88719738	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:88719738G>A	uc002flg.1	-	9	1099	c.1092C>T	c.(1090-1092)CCC>CCT	p.P364P	CYBA_uc002flb.2_5'Flank|CYBA_uc002fld.1_5'Flank|CYBA_uc010chx.1_5'Flank|CYBA_uc002fle.1_5'Flank|MVD_uc002flf.1_Silent_p.P233P	NM_002461	NP_002452	P53602	MVD1_HUMAN	diphosphomevalonate decarboxylase	364					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TGACCCCACCGGGGGTCGGCT	0.667													9	14					0	0	0.008291	0	0
APRT	353	broad.mit.edu	37	16	88876248	88876249	+	Splice_Site	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:88876248_88876249CC>TT	uc002flv.2	-	5	436	c.401_splice	c.e5-1	p.G134_splice	APRT_uc002flw.2_Intron	NM_000485	NP_000476	P07741	APT_HUMAN	adenine phosphoribosyltransferase isoform a						purine ribonucleoside salvage	cytosol|nucleus	adenine phosphoribosyltransferase activity|AMP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)	Adenine(DB00173)|Adenosine monophosphate(DB00131)	GTTCATGGTTCCTGGGGATGGG	0.663													6	21					0	0	0.004672	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351405	89351405	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:89351405G>A	uc002fmx.1	-	9	2006	c.1545C>T	c.(1543-1545)TTC>TTT	p.F515F	ANKRD11_uc002fmy.1_Silent_p.F515F|ANKRD11_uc002fnc.1_Silent_p.F515F|ANKRD11_uc002fnb.1_Silent_p.F472F	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	515	Ser-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		AGAGGGAGCTGAACAGGGAGG	0.647													18	41					0	0	0.004990	0	0
SPIRE2	84501	broad.mit.edu	37	16	89922062	89922062	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:89922062G>A	uc002foz.1	+	6	998	c.946G>A	c.(946-948)GAC>AAC	p.D316N	SPIRE2_uc010civ.1_Missense_Mutation_p.D231N|SPIRE2_uc010ciw.1_Missense_Mutation_p.D316N|SPIRE2_uc002fpa.1_Missense_Mutation_p.D268N|SPIRE2_uc010cix.1_Missense_Mutation_p.D183N	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	316					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		GCTCATCCTGGACTTTATCCG	0.677													11	23					0	0	0.002450	0	0
PRDM7	11105	broad.mit.edu	37	16	90142339	90142339	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:90142339G>A	uc010cje.2	-	1	1	c.-19_splice	c.e1-1		PRDM7_uc010cjf.2_Splice_Site|PRDM7_uc010cjh.1_Splice_Site	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1							chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTGTCTAGAAGGCCCTGCTCC	0.587													8	17					0	0	0.004482	0	0
SMYD4	114826	broad.mit.edu	37	17	1690790	1690790	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:1690790G>A	uc002ftm.3	-	6	1814	c.1646C>T	c.(1645-1647)TCC>TTC	p.S549F	SMYD4_uc002ftn.1_Missense_Mutation_p.S404F	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	549	SET.						zinc ion binding			skin(3)|kidney(2)	5						GCTAATGAAGGACACGCTGGT	0.587													4	3					0	0	0.000248	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2883636	2883636	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:2883636C>T	uc010ckd.2	+	9	742	c.652C>T	c.(652-654)CCC>TCC	p.P218S	RAP1GAP2_uc010cke.2_Missense_Mutation_p.P203S	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	218					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						GAGCAAGCTTCCCAGTGTCCC	0.547													11	21					0	0	0.001855	0	0
OR3A2	4995	broad.mit.edu	37	17	3181450	3181450	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:3181450G>A	uc002fvg.2	-	1	819	c.780C>T	c.(778-780)TTC>TTT	p.F260F		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	260	Helical; Name=6; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CTCTTCCAAAGAAAAGACAAA	0.507													17	32					0	0	0.007413	0	0
SPATA22	84690	broad.mit.edu	37	17	3349846	3349846	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:3349846C>T	uc002fvm.2	-	7	959	c.722G>A	c.(721-723)AGA>AAA	p.R241K	SPATA22_uc010vrg.1_Missense_Mutation_p.R225K|SPATA22_uc010vrf.1_Missense_Mutation_p.R241K|SPATA22_uc002fvn.2_Missense_Mutation_p.R241K|SPATA22_uc002fvo.2_Missense_Mutation_p.R241K|SPATA22_uc002fvp.2_Missense_Mutation_p.R241K|SPATA22_uc010ckf.2_Missense_Mutation_p.R198K	NM_032598	NP_115987	Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	241											0						AGAAATAATTCTTAAAGAACT	0.269													7	12					0	0	0.001984	0	0
CAMKK1	84254	broad.mit.edu	37	17	3772873	3772873	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:3772873G>C	uc002fwt.2	-	14	1343	c.1249C>G	c.(1249-1251)CTT>GTT	p.L417V	CAMKK1_uc002fwu.2_Missense_Mutation_p.L417V|CAMKK1_uc002fwv.2_Missense_Mutation_p.L455V	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	417					synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		TCCGAAGGAAGGGGCTCCTCC	0.622													18	24					0	0	0.007413	0	0
ATP2A3	489	broad.mit.edu	37	17	3844779	3844779	+	Missense_Mutation	SNP	C	T	T	rs112116136	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:3844779C>T	uc002fxb.1	-	13	1866	c.1715G>A	c.(1714-1716)AGG>AAG	p.R572K	ATP2A3_uc002fwx.1_Missense_Mutation_p.R572K|ATP2A3_uc002fwy.1_Missense_Mutation_p.R572K|ATP2A3_uc002fwz.1_Missense_Mutation_p.R572K|ATP2A3_uc002fxa.1_Missense_Mutation_p.R572K|ATP2A3_uc002fxc.1_Missense_Mutation_p.R572K|ATP2A3_uc002fxd.1_Missense_Mutation_p.R572K	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	572	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GTCCTCCTTCCTTGGGGGCGC	0.647													26	30					0	0	0.005443	0	0
ZZEF1	23140	broad.mit.edu	37	17	3937384	3937385	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:3937384_3937385CC>TT	uc002fxe.2	-	40	6572_6573	c.6508_6509GG>AA	c.(6508-6510)GGG>AAG	p.G2170K	ZZEF1_uc002fxh.2_Missense_Mutation_p.G484K|ZZEF1_uc002fxi.2_Missense_Mutation_p.G405K|ZZEF1_uc002fxj.1_Missense_Mutation_p.G783K	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2170							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGAACTGTCCCCTGCAGCAAAC	0.545													41	62					0	0	0.004672	0	0
SPNS3	201305	broad.mit.edu	37	17	4352556	4352556	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:4352556G>A	uc002fxt.2	+	7	841	c.797G>A	c.(796-798)GGA>GAA	p.G266E	SPNS3_uc002fxu.2_Missense_Mutation_p.G139E	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	266	Helical; (Potential).				lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						TCGACCCTCGGAGTGACCGCC	0.657													26	41					0	0	0.001786	0	0
PLD2	5338	broad.mit.edu	37	17	4722875	4722875	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:4722875C>T	uc002fzc.2	+	23	2561	c.2460C>T	c.(2458-2460)TTC>TTT	p.F820F	PLD2_uc002fzd.2_Intron	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	820					cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	AGCACTGCTTCGGGTAGAGCT	0.617													15	15					0	0	0.003163	0	0
ZFP3	124961	broad.mit.edu	37	17	4995744	4995744	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:4995744G>A	uc002gaq.2	+	2	1070	c.945G>A	c.(943-945)GGG>GGA	p.G315G		NM_153018	NP_694563	Q96NJ6	ZFP3_HUMAN	zinc finger protein-3	315	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGAATGTGGGAAGGGCTTCG	0.433													9	10					0	0	0.006214	0	0
USP6	9098	broad.mit.edu	37	17	5036747	5036747	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:5036747C>T	uc002gau.1	+	14	2516	c.286C>T	c.(286-288)CGA>TGA	p.R96*	USP6_uc002gav.1_Nonsense_Mutation_p.R96*|USP6_uc010ckz.1_5'UTR|USP6_uc002gaw.2_Nonsense_Mutation_p.R157*|uc002gay.1_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	96					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						GCTCATAGATCGAGTGTACAA	0.522			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								26	49					0	0	0.008361	0	0
DVL2	1856	broad.mit.edu	37	17	7132931	7132931	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:7132931C>T	uc002gez.1	-	6	1005	c.723G>A	c.(721-723)AAG>AAA	p.K241K	DVL2_uc010vtr.1_Silent_p.K235K|DVL2_uc010vts.1_Silent_p.K143K|DVL2_uc010clz.1_3'UTR	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	241					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						GTGGCCTCTGCTTCCTTCGCC	0.647													22	41					0	0	0.002780	0	0
TNFSF12-TNFSF13	407977	broad.mit.edu	37	17	7460146	7460146	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:7460146G>A	uc002ghi.1	+	6	480	c.425G>A	c.(424-426)AGC>AAC	p.S142N	TNFSF12_uc002ghg.2_Missense_Mutation_p.S142N|TNFSF12_uc002ghh.2_RNA|TNFSF13_uc002ghj.2_5'Flank|TNFSF13_uc002ghk.2_5'Flank|TNFSF13_uc002ghl.2_5'Flank|TNFSF13_uc010cmk.2_5'Flank|TNFSF13_uc010vua.1_5'Flank	NM_172089	NP_742086	Q8IZK7	Q8IZK7_HUMAN	TNFSF12-TNFSF13 protein	142					immune response	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding				0		Prostate(122;0.157)				AACAGCTCCAGCCCTCTGCGC	0.567													20	16					0	0	0.007413	0	0
DNAH2	146754	broad.mit.edu	37	17	7673712	7673712	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:7673712C>T	uc002giu.1	+	24	4098	c.4084C>T	c.(4084-4086)CTG>TTG	p.L1362L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1362	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AACTAAAGAGCTGGCTATAGA	0.537													17	14					0	0	0.004007	0	0
PFAS	5198	broad.mit.edu	37	17	8157260	8157260	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:8157260C>T	uc002gkr.2	+	2	146	c.5C>T	c.(4-6)TCC>TTC	p.S2F	PFAS_uc010vuv.1_5'UTR	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	2					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCAGAGATGTCCCCAGTCCTT	0.522													8	10					0	0	0.003080	0	0
MYH10	4628	broad.mit.edu	37	17	8451692	8451692	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:8451692A>C	uc002gll.2	-	10	1164	c.1068T>G	c.(1066-1068)TTT>TTG	p.F356L	MYH10_uc002glm.2_Missense_Mutation_p.F366L|MYH10_uc010cnx.2_Missense_Mutation_p.F365L	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	356	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						AAATATTTCCAAACTGTAGCA	0.313													16	52					0	0	0.007413	0	0
MFSD6L	162387	broad.mit.edu	37	17	8702206	8702206	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:8702206G>A	uc002glp.1	-	1	381	c.233C>T	c.(232-234)GCG>GTG	p.A78V		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	78	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						GATCAGAAGCGCTCTCCTTTT	0.612													24	28					0	0	0.003330	0	0
DHRS7C	201140	broad.mit.edu	37	17	9694459	9694460	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:9694459_9694460CC>TT	uc010vvb.1	-	1	142_143	c.142_143GG>AA	c.(142-144)GGA>AAA	p.G48K	DHRS7C_uc010cof.2_Missense_Mutation_p.G48K	NM_001105571	NP_001099041	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	48	NAD or NADP (By similarity).					extracellular region	binding|oxidoreductase activity				0						CTTGCCCAGTCCTGAGATGGCA	0.604													3	4					0	0	0.004672	0	0
MYH8	4626	broad.mit.edu	37	17	10300303	10300303	+	Silent	SNP	C	T	T	rs143515663		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:10300303C>T	uc002gmm.2	-	31	4274	c.4179G>A	c.(4177-4179)AAG>AAA	p.K1393K	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1393	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CCAACTTTTTCCTGAAAAGTT	0.463									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				8	18					0	0	0.003080	0	0
MYH4	4622	broad.mit.edu	37	17	10355446	10355446	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:10355446C>T	uc002gmn.2	-	27	3661	c.3550G>A	c.(3550-3552)GAG>AAG	p.E1184K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1184	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AGGGTGGACTCTTCCAGGTCC	0.587													31	39					0	0	0.001786	0	0
MYH3	4621	broad.mit.edu	37	17	10541482	10541482	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:10541482C>T	uc002gmq.1	-	26	3684	c.3607G>A	c.(3607-3609)GAG>AAG	p.E1203K		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1203	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TCCCCAAGCTCGGCCACACTA	0.602													23	31					0	0	0.002299	0	0
DNAH9	1770	broad.mit.edu	37	17	11593583	11593583	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:11593583C>T	uc002gne.2	+	20	4512	c.4444C>T	c.(4444-4446)CTG>TTG	p.L1482L	DNAH9_uc010coo.2_Silent_p.L776L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1482	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACTTCAGAACCTGGTGATGTC	0.507													29	40					0	0	0.007291	0	0
MYOCD	93649	broad.mit.edu	37	17	12647617	12647617	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:12647617C>T	uc002gnn.2	+	8	1134	c.835C>T	c.(835-837)CCT>TCT	p.P279S	MYOCD_uc002gno.2_Missense_Mutation_p.P279S|MYOCD_uc002gnp.1_Missense_Mutation_p.P183S|MYOCD_uc002gnq.2_5'UTR	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	279					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGAGAAGTCCCCTCCACCTAT	0.488													13	20					0	0	0.002450	0	0
MYOCD	93649	broad.mit.edu	37	17	12656388	12656388	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:12656388G>A	uc002gnn.2	+	10	2082	c.1783G>A	c.(1783-1785)GAG>AAG	p.E595K	MYOCD_uc002gno.2_Missense_Mutation_p.E595K|MYOCD_uc002gnp.1_Missense_Mutation_p.E499K|MYOCD_uc002gnq.2_Missense_Mutation_p.E314K	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	595					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CAGCAGCTCAGAGTGTCACCC	0.517													27	39					0	0	0.002096	0	0
ZNF286A	57335	broad.mit.edu	37	17	15619996	15619996	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:15619996C>T	uc010cot.2	+	6	1354	c.958C>T	c.(958-960)CAC>TAC	p.H320Y	ZNF286A_uc002goz.3_Missense_Mutation_p.H208Y|ZNF286A_uc010vwa.1_Missense_Mutation_p.H320Y|ZNF286A_uc002gpa.2_Missense_Mutation_p.H320Y	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	320	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		TCAGAGAATTCACGTTGGAGA	0.403													12	23					0	0	0.002450	0	0
NCOR1	9611	broad.mit.edu	37	17	15961014	15961014	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:15961014G>A	uc002gpo.2	-	40	6446	c.6206C>T	c.(6205-6207)TCC>TTC	p.S2069F	NCOR1_uc002gpn.2_Missense_Mutation_p.S1966F|NCOR1_uc002gpl.2_Missense_Mutation_p.S84F|NCOR1_uc002gpm.2_Missense_Mutation_p.S589F|NCOR1_uc010vwb.1_Missense_Mutation_p.S653F|NCOR1_uc010coy.2_Missense_Mutation_p.S977F|NCOR1_uc010vwc.1_Missense_Mutation_p.S879F	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2069	Interaction with C1D (By similarity).|ID1 (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGTCTGCGAGGAAACTTGATT	0.388													24	19					0	0	0.003954	0	0
MYO15A	51168	broad.mit.edu	37	17	18022156	18022156	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:18022156G>A	uc010vxh.1	+	2	380	c.42G>A	c.(40-42)GGG>GGA	p.G14G		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	14	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					ccaagaaagggaagaagggga	0.413													3	4					0	0	0.004672	0	0
SMCR8	140775	broad.mit.edu	37	17	18220793	18220793	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:18220793C>T	uc002gsy.3	+	1	2200	c.1690C>T	c.(1690-1692)CCA>TCA	p.P564S		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	564										central_nervous_system(1)	1						CATCAGTCCTCCAGAACTGGG	0.493													37	64					0	0	0.005524	0	0
Unknown	0	broad.mit.edu	37	17	25753503	25753503	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:25753503C>T	uc002gzg.2	+	11		c.1513C>T			uc002gzi.1_5'Flank					Homo sapiens similar to ubiquitin specific protease 6, mRNA (cDNA clone IMAGE:5168266), with apparent retained intron.																		TCGGGCTCACCCCGTGCCTGT	0.567													26	10					0	0	0.001786	0	0
IFT20	90410	broad.mit.edu	37	17	26659002	26659002	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:26659002C>T	uc002haw.1	-	2	142	c.10G>A	c.(10-12)GAC>AAC	p.D4N	IFT20_uc002hau.1_Missense_Mutation_p.D4N|IFT20_uc002hav.1_Missense_Mutation_p.D30N|IFT20_uc010wae.1_Missense_Mutation_p.D30N|TNFAIP1_uc002hax.1_Intron			Q8IY31	IFT20_HUMAN	RecName: Full=Intraflagellar transport protein 20 homolog;          Short=hIFT20;	4					cell projection organization	centriole|cilium|Golgi apparatus|microtubule basal body	protein binding				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CCCAGGATGTCCTTGGCCATG	0.552													44	27					0	0	0.003610	0	0
SLC13A2	9058	broad.mit.edu	37	17	26823500	26823500	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:26823500C>T	uc002hbh.2	+	11	1570	c.1503C>T	c.(1501-1503)GTC>GTT	p.V501V	SLC13A2_uc010wam.1_Silent_p.V457V|SLC13A2_uc010wan.1_Silent_p.V550V|SLC13A2_uc010wao.1_Silent_p.V458V|SLC13A2_uc002hbi.2_Silent_p.V430V	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	501	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CTCTCTACGTCATGCTCCCCT	0.642													39	95					0	0	0.006230	0	0
TAOK1	57551	broad.mit.edu	37	17	27816697	27816697	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:27816697C>T	uc002hdz.1	+	9	865	c.671C>T	c.(670-672)CCT>CTT	p.P224L	TAOK1_uc010wbe.1_Missense_Mutation_p.P224L|TAOK1_uc010wbf.1_Missense_Mutation_p.P224L|TAOK1_uc002heb.1_Missense_Mutation_p.P50L	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	224	Protein kinase.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			AGGAAGCCTCCTTTATTTAAT	0.348													20	63					0	0	0.001523	0	0
SSH2	85464	broad.mit.edu	37	17	27958542	27958542	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:27958542C>T	uc002heo.1	-	15	3589	c.3589G>A	c.(3589-3591)GGG>AGG	p.G1197R	SSH2_uc010wbh.1_Missense_Mutation_p.G1224R	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	1197					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TGTAACTCCCCAGTGTTGTCA	0.502													34	117					0	0	0.006230	0	0
SSH2	85464	broad.mit.edu	37	17	27959827	27959827	+	Silent	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:27959827C>A	uc002heo.1	-	15	2304	c.2304G>T	c.(2302-2304)CTG>CTT	p.L768L	SSH2_uc010wbh.1_Silent_p.L795L	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	768					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TGTCTCCTTTCAGTTGAATCT	0.463													11	41					6.40141e-05	9.69018e-05	0.000978	1	0
EFCAB5	374786	broad.mit.edu	37	17	28380942	28380942	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:28380942G>A	uc002het.2	+	10	2162	c.1970G>A	c.(1969-1971)GGA>GAA	p.G657E	EFCAB5_uc010wbi.1_Missense_Mutation_p.G400E|EFCAB5_uc010wbj.1_Missense_Mutation_p.G601E|EFCAB5_uc010wbk.1_Missense_Mutation_p.G314E|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Missense_Mutation_p.G536E|EFCAB5_uc010csf.2_Missense_Mutation_p.G536E	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	657							calcium ion binding			ovary(1)|skin(1)	2						GGACCTTATGGAGAGATAATT	0.388													43	24					0	0	0.002222	0	0
RFFL	117584	broad.mit.edu	37	17	33348531	33348531	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:33348531G>A	uc002hin.1	-	3	623	c.450C>T	c.(448-450)ACC>ACT	p.T150T	RFFL_uc002hiq.2_Intron|RFFL_uc002him.1_Silent_p.T150T|RFFL_uc010cti.1_Silent_p.T156T|RFFL_uc002hip.1_Silent_p.T150T|RFFL_uc002hio.1_Silent_p.T150T	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	150					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CTGGGGACAAGGTGGAGGCAC	0.577													10	9					0	0	0.006214	0	0
SLFN13	146857	broad.mit.edu	37	17	33772396	33772396	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:33772396C>T	uc002hjk.1	-	1	634	c.304G>A	c.(304-306)GGA>AGA	p.G102R	SLFN13_uc010wch.1_Missense_Mutation_p.G102R|SLFN13_uc002hjl.2_Missense_Mutation_p.G102R|SLFN13_uc010ctt.2_Intron|SLFN13_uc002hjm.2_5'UTR	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	102						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AAACACCTTCCGTGTTGCTTA	0.388													21	27					0	0	0.001882	0	0
CCL15	6359	broad.mit.edu	37	17	34324841	34324841	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:34324841G>A	uc010wcu.1	-	4	873	c.304C>T	c.(304-306)CAG>TAG	p.Q102*	CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA	NM_032965	NP_116741	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15 precursor	102					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ATGCAATCCTGAACTCCCGGA	0.498													15	17					0	0	0.004990	0	0
LHX1	3975	broad.mit.edu	37	17	35300134	35300134	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:35300134G>A	uc002hnh.1	+	5	1923	c.927G>A	c.(925-927)GTG>GTA	p.V309V		NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	309					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				AGACACCAGTGGACCTACCCT	0.716													6	1					0	0	0.001168	0	0
C17orf78	284099	broad.mit.edu	37	17	35736173	35736173	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:35736173G>C	uc002hns.2	+	3	294	c.244G>C	c.(244-246)GTA>CTA	p.V82L	ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc002hnq.2_Intron|C17orf78_uc010cva.1_Missense_Mutation_p.V82L	NM_173625	NP_775896	Q8N4C9	CQ078_HUMAN	hypothetical protein LOC284099	82						integral to membrane					0		Breast(25;0.00295)|Ovarian(249;0.15)				AGTCAACCTTGTATATTTGGA	0.453													3	130					0	0	0.004672	0	0
GPR179	440435	broad.mit.edu	37	17	36486596	36486596	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:36486596C>T	uc002hpz.2	-	11	2877	c.2856G>A	c.(2854-2856)AGG>AGA	p.R952R		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	952	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GAGATAGCATCCTTGGCTCTC	0.468													9	3					0	0	0.004482	0	0
GPR179	440435	broad.mit.edu	37	17	36487299	36487299	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:36487299G>A	uc002hpz.2	-	11	2174	c.2153C>T	c.(2152-2154)TCC>TTC	p.S718F		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	718	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCTCATGAAGGAGCGGCCCAG	0.657													22	8					0	0	0.001882	0	0
GPR179	440435	broad.mit.edu	37	17	36493589	36493589	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:36493589C>T	uc002hpz.2	-	3	939	c.918G>A	c.(916-918)GAG>GAA	p.E306E		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	306	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGCCCTGACTCTCCAGGGGAA	0.572													38	18					0	0	0.007835	0	0
GPR179	440435	broad.mit.edu	37	17	36499518	36499518	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:36499518G>A	uc002hpz.2	-	1	176	c.155C>T	c.(154-156)CCC>CTC	p.P52L		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	52	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCCCTCTAGGGGCACCTGCAT	0.617													33	19					0	0	0.006230	0	0
TOP2A	7153	broad.mit.edu	37	17	38546331	38546331	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:38546331G>A	uc002huq.2	-	34	4479	c.4353C>T	c.(4351-4353)GTC>GTT	p.V1451V		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	1451					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	GCTTTTGAGAGACACCAGAAT	0.443													13	16					0	0	0.001855	0	0
KRT25	147183	broad.mit.edu	37	17	38910165	38910165	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:38910165G>A	uc002hve.2	-	3	677	c.616C>T	c.(616-618)CAG>TAG	p.Q206*		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	206	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				GTTTCATACTGAATCTCCAGA	0.448													84	57					0	0	0.003610	0	0
KRT33A	3883	broad.mit.edu	37	17	39504771	39504771	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:39504771C>T	uc002hwk.1	-	3	589	c.552G>A	c.(550-552)AAG>AAA	p.K184K		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	184	Rod.|Coil 1B.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				GCAGCTCCTCCTTCAGGGACT	0.597													21	56					0	0	0.002299	0	0
KRT37	8688	broad.mit.edu	37	17	39580567	39580567	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:39580567G>A	uc002hwp.1	-	1	256	c.209C>T	c.(208-210)CCC>CTC	p.P70L	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	70	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				ACTGGTTGGGGGCAGACAGAG	0.622													12	33					0	0	0.003163	0	0
KCNH4	23415	broad.mit.edu	37	17	40330388	40330388	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:40330388C>T	uc002hzb.2	-	3	751	c.418G>A	c.(418-420)GGA>AGA	p.G140R		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	140	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGGCCAAGTCCTGGGCTTCCA	0.562													24	10					0	0	0.004656	0	0
RUNDC1	146923	broad.mit.edu	37	17	41143029	41143029	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:41143029C>T	uc002ici.1	+	5	1150	c.1138C>T	c.(1138-1140)CCC>TCC	p.P380S	RUNDC1_uc010whi.1_Missense_Mutation_p.P150S	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	380											0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		AGACTACTCTCCCTTGCTGAA	0.577													23	16					0	0	0.001882	0	0
NBR1	4077	broad.mit.edu	37	17	41341698	41341698	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:41341698C>T	uc010czd.2	+	8	714	c.574C>T	c.(574-576)CCC>TCC	p.P192S	NBR1_uc010diz.2_Missense_Mutation_p.P192S|NBR1_uc010whu.1_Missense_Mutation_p.P192S|NBR1_uc010whv.1_Missense_Mutation_p.P192S|NBR1_uc010whw.1_Missense_Mutation_p.P171S|NBR1_uc010whx.1_5'Flank	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	192					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GGGTTCTTGTCCCTCAGAAGT	0.418													43	116					0	0	0.002522	0	0
DHX8	1659	broad.mit.edu	37	17	41569586	41569586	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:41569586G>A	uc002idu.1	+	5	502	c.429G>A	c.(427-429)GTG>GTA	p.V143V	DHX8_uc010wif.1_Silent_p.V52V|DHX8_uc010wig.1_Silent_p.V143V	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	143						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		AAGTTGCTGTGGATGTCCTGA	0.473													32	30					0	0	0.002836	0	0
DHX8	1659	broad.mit.edu	37	17	41599556	41599556	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:41599556C>T	uc002idu.1	+	22	3478	c.3405C>T	c.(3403-3405)ATC>ATT	p.I1135I	DHX8_uc010wig.1_Silent_p.I1135I	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	1135						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		TGGTCTATATCCATCCTTCCA	0.532													21	47					0	0	0.002299	0	0
NMT1	4836	broad.mit.edu	37	17	43171163	43171163	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:43171163C>T	uc002ihz.2	+	4	514	c.496C>T	c.(496-498)CGT>TGT	p.R166C	NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	166					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				CCTGGGCGATCGTGGTGTGGT	0.602													13	28					0	0	0.004007	0	0
WNT9B	7484	broad.mit.edu	37	17	44953631	44953631	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:44953631G>A	uc002ikw.1	+	4	658	c.621G>A	c.(619-621)AGG>AGA	p.R207R	WNT9B_uc002ikx.1_Silent_p.R207R	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	207					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GTGGCCTCAGGACCACGTGTA	0.657													10	19					0	0	0.006214	0	0
HOXB13	10481	broad.mit.edu	37	17	46804343	46804343	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:46804343G>A	uc002ioa.2	-	2	820	c.664C>T	c.(664-666)CCG>TCG	p.P222S	hsa-mir-3185|MI0014227_5'Flank	NM_006361	NP_006352	Q92826	HXB13_HUMAN	homeobox B13	222	Homeobox.				angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTGCTGTACGGAATGCGTTTC	0.627													44	30					0	0	0.002852	0	0
COL1A1	1277	broad.mit.edu	37	17	48268227	48268227	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:48268227A>G	uc002iqm.2	-	33	2420	c.2294T>C	c.(2293-2295)CTG>CCG	p.L765P		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	765	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	GGGGCCAGTCAGACCACGGAC	0.592			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						29	12					0	0	0.003755	0	0
SPATA20	64847	broad.mit.edu	37	17	48626486	48626486	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:48626486C>T	uc002irf.2	+	5	692	c.551C>T	c.(550-552)CCT>CTT	p.P184L	SPATA20_uc002irc.2_5'UTR|SPATA20_uc002ire.2_Missense_Mutation_p.P140L|SPATA20_uc002ird.2_Missense_Mutation_p.P200L|SPATA20_uc010wmv.1_Missense_Mutation_p.P210L|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	184					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			ACCTATTTCCCTCCTGAGGAT	0.652													14	40					0	0	0.002450	0	0
CACNA1G	8913	broad.mit.edu	37	17	48674275	48674275	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:48674275G>A	uc002irk.1	+	16	3621	c.3249G>A	c.(3247-3249)ATG>ATA	p.M1083I	CACNA1G_uc002iri.1_Missense_Mutation_p.M1083I|CACNA1G_uc002irj.1_Missense_Mutation_p.M1060I|CACNA1G_uc002irl.1_Missense_Mutation_p.M1060I|CACNA1G_uc002irm.1_Missense_Mutation_p.M1060I|CACNA1G_uc002irn.1_Missense_Mutation_p.M1060I|CACNA1G_uc002iro.1_Missense_Mutation_p.M1060I|CACNA1G_uc002irp.1_Missense_Mutation_p.M1083I|CACNA1G_uc002irq.1_Missense_Mutation_p.M1060I|CACNA1G_uc002irr.1_Missense_Mutation_p.M1083I|CACNA1G_uc002irs.1_Missense_Mutation_p.M1083I|CACNA1G_uc002irt.1_Missense_Mutation_p.M1083I|CACNA1G_uc002irv.1_Missense_Mutation_p.M1083I|CACNA1G_uc002irw.1_Missense_Mutation_p.M1060I|CACNA1G_uc002iru.1_Missense_Mutation_p.M1060I|CACNA1G_uc002irx.1_Missense_Mutation_p.M996I|CACNA1G_uc002iry.1_Missense_Mutation_p.M996I|CACNA1G_uc002irz.1_Missense_Mutation_p.M996I|CACNA1G_uc002isa.1_Missense_Mutation_p.M996I|CACNA1G_uc002isb.1_Missense_Mutation_p.M996I|CACNA1G_uc002isc.1_Missense_Mutation_p.M996I|CACNA1G_uc002isd.1_Missense_Mutation_p.M996I|CACNA1G_uc002ise.1_Missense_Mutation_p.M996I|CACNA1G_uc002isf.1_Missense_Mutation_p.M996I|CACNA1G_uc002isg.1_Missense_Mutation_p.M996I|CACNA1G_uc002ish.1_Missense_Mutation_p.M996I|CACNA1G_uc002isi.1_Missense_Mutation_p.M973I|CACNA1G_uc002isj.2_5'Flank	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1083	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCCACGAGATGAAGTCACCGG	0.682													3	3					0	0	0.004672	0	0
CACNA1G	8913	broad.mit.edu	37	17	48683279	48683279	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:48683279C>T	uc002irk.1	+	23	4689	c.4317C>T	c.(4315-4317)TTC>TTT	p.F1439F	CACNA1G_uc002iri.1_Silent_p.F1439F|CACNA1G_uc002irj.1_Silent_p.F1416F|CACNA1G_uc002irl.1_Silent_p.F1416F|CACNA1G_uc002irm.1_Silent_p.F1416F|CACNA1G_uc002irn.1_Silent_p.F1416F|CACNA1G_uc002iro.1_Silent_p.F1416F|CACNA1G_uc002irp.1_Silent_p.F1439F|CACNA1G_uc002irq.1_Silent_p.F1416F|CACNA1G_uc002irr.1_Silent_p.F1439F|CACNA1G_uc002irs.1_Silent_p.F1439F|CACNA1G_uc002irt.1_Silent_p.F1439F|CACNA1G_uc002irv.1_Silent_p.F1439F|CACNA1G_uc002irw.1_Silent_p.F1416F|CACNA1G_uc002iru.1_Silent_p.F1416F|CACNA1G_uc002irx.1_Silent_p.F1352F|CACNA1G_uc002iry.1_Silent_p.F1352F|CACNA1G_uc002irz.1_Silent_p.F1352F|CACNA1G_uc002isa.1_Silent_p.F1352F|CACNA1G_uc002isb.1_Silent_p.F1352F|CACNA1G_uc002isc.1_Silent_p.F1352F|CACNA1G_uc002isd.1_Silent_p.F1352F|CACNA1G_uc002ise.1_Silent_p.F1352F|CACNA1G_uc002isf.1_Silent_p.F1352F|CACNA1G_uc002isg.1_Silent_p.F1352F|CACNA1G_uc002ish.1_Silent_p.F1352F|CACNA1G_uc002isi.1_Silent_p.F1329F|CACNA1G_uc002isj.2_Silent_p.F163F	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1439	Extracellular (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGAAGTTTTTCGTGTGCCAGG	0.552													32	26					0	0	0.003755	0	0
CA10	56934	broad.mit.edu	37	17	50008441	50008441	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:50008441C>T	uc002itw.3	-	3	1174	c.188G>A	c.(187-189)GGG>GAG	p.G63E	CA10_uc002itv.3_Missense_Mutation_p.G69E|CA10_uc002itx.3_Missense_Mutation_p.G63E|CA10_uc002ity.3_Missense_Mutation_p.G63E|CA10_uc002itz.2_Missense_Mutation_p.G63E	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	63					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			CTGCCGTTTCCCCACAGAGCA	0.488													49	253					0	0	0.003610	0	0
HLF	3131	broad.mit.edu	37	17	53342916	53342916	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:53342916C>T	uc002iug.1	+	1	596	c.71C>T	c.(70-72)TCC>TTC	p.S24F	HLF_uc010dce.1_5'Flank|HLF_uc002iuh.2_5'Flank|HLF_uc010wni.1_5'Flank	NM_002126	NP_002117	Q16534	HLF_HUMAN	hepatic leukemia factor	24					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						GTGCTCAGGTCCCTGCTGGAG	0.637			T	TCF3	ALL								8	42					0	0	0.001368	0	0
ANKFN1	162282	broad.mit.edu	37	17	54450167	54450167	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:54450167C>T	uc002iun.1	+	6	806	c.771C>T	c.(769-771)CTC>CTT	p.L257L		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	257										large_intestine(1)|ovary(1)	2						GGTATCGGCTCTACAGACGCA	0.483													130	90					0	0	0.003610	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386068	56386068	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:56386068G>A	uc002ivx.3	-	22	5436	c.4565C>T	c.(4564-4566)CCT>CTT	p.P1522L	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Missense_Mutation_p.P1462L|BZRAP1_uc010wnt.1_Missense_Mutation_p.P1522L	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1522						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCCATCTCCAGGGTAGCAGGA	0.627													33	15					0	0	0.002096	0	0
BZRAP1	9256	broad.mit.edu	37	17	56388315	56388315	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:56388315G>A	uc002ivx.3	-	19	4212	c.3341C>T	c.(3340-3342)TCT>TTT	p.S1114F	BZRAP1_uc010dcs.2_Missense_Mutation_p.S1054F|BZRAP1_uc010wnt.1_Missense_Mutation_p.S1114F	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1114	Pro-rich.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGGAGAGGAGAGCTGGGGTC	0.672													15	13					0	0	0.004990	0	0
C17orf71	55181	broad.mit.edu	37	17	57290426	57290427	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:57290426_57290427CC>TT	uc002ixi.2	+	3	2284_2285	c.2242_2243CC>TT	c.(2242-2244)CCA>TTA	p.P748L		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	748					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					TGAGTATCTCCCAGGCATGCTA	0.441													70	29					0	0	0.004672	0	0
DHX40	79665	broad.mit.edu	37	17	57650525	57650525	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:57650525C>T	uc002ixn.1	+	4	622	c.475C>T	c.(475-477)CTG>TTG	p.L159L	DHX40_uc010woe.1_Silent_p.L82L|DHX40_uc002ixo.1_Silent_p.L60L	NM_024612	NP_078888	Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	159	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GAAACATATTCTGGGAGACCC	0.328													119	60					0	0	0.003610	0	0
METTL2A	339175	broad.mit.edu	37	17	60503710	60503710	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:60503710C>T	uc002izv.2	+	3	271	c.253C>T	c.(253-255)CAC>TAC	p.H85Y	METTL2A_uc002izw.2_5'UTR	NM_181725	NP_859076	Q96IZ6	MTL2A_HUMAN	methyltransferase like 2A	85							methyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(2;1.08e-10)			CTACAAAATCCACGAAAATGG	0.348													11	47					0	0	0.001855	0	0
MRC2	9902	broad.mit.edu	37	17	60749032	60749032	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:60749032G>A	uc002jad.2	+	7	1542	c.1140G>A	c.(1138-1140)GTG>GTA	p.V380V	MRC2_uc002jac.2_Silent_p.V380V	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	380	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ATGTGAAGGTGGAGTGCGAGC	0.642													18	36					0	0	0.006122	0	0
TANC2	26115	broad.mit.edu	37	17	61466735	61466735	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:61466735C>T	uc002jal.3	+	15	2682	c.2659C>T	c.(2659-2661)CCA>TCA	p.P887S	TANC2_uc010wpe.1_Missense_Mutation_p.P797S|TANC2_uc002jan.1_Missense_Mutation_p.P38S|TANC2_uc002jao.3_5'UTR|TANC2_uc002jam.1_Missense_Mutation_p.P254S	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	887	ANK 2.						binding			ovary(2)	2						AAATAATGCTCCAATTCTATG	0.443													37	50					0	0	0.003214	0	0
TANC2	26115	broad.mit.edu	37	17	61499273	61499273	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:61499273C>T	uc002jal.3	+	25	5953	c.5930C>T	c.(5929-5931)TCC>TTC	p.S1977F	TANC2_uc010wpe.1_3'UTR|TANC2_uc002jao.3_Missense_Mutation_p.S1088F	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1977							binding			ovary(2)	2						GGGCAGACATCCCCTATCAAA	0.502													19	68					0	0	0.007413	0	0
TEX2	55852	broad.mit.edu	37	17	62290858	62290858	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:62290858G>A	uc002jec.2	-	2	893	c.720C>T	c.(718-720)TCC>TCT	p.S240S	TEX2_uc002jed.2_Silent_p.S240S|TEX2_uc002jee.2_Silent_p.S240S	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	240					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		AGTTCAGTTTGGAATCAGGTG	0.507													20	79					0	0	0.001523	0	0
CCDC46	201134	broad.mit.edu	37	17	63898358	63898358	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:63898358C>T	uc002jfl.2	-	20	2294	c.2075G>A	c.(2074-2076)CGG>CAG	p.R692Q	CCDC46_uc010deo.2_Missense_Mutation_p.R434Q|CCDC46_uc002jfm.2_Missense_Mutation_p.R692Q|CCDC46_uc010dep.2_Missense_Mutation_p.R650Q	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	692	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			TTCAATTTCCCGTTCATGGTC	0.443													20	56					0	0	0.001523	0	0
HELZ	9931	broad.mit.edu	37	17	65082989	65082989	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:65082989G>A	uc010wqk.1	-	32	5640	c.5453C>T	c.(5452-5454)CCG>CTG	p.P1818L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.P1817L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TCCATTGCACGGAATGTTCTG	0.473													36	99					0	0	0.006230	0	0
LOC651250	651250	broad.mit.edu	37	17	66110660	66110660	+	RNA	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:66110660T>C	uc002jgq.2	+	4		c.751T>C			LOC651250_uc002kit.2_RNA|LOC651250_uc002jgo.1_RNA	NR_027418				Homo sapiens cDNA FLJ33831 fis, clone CTONG2003937.												0						TACGGAGGGGTTGCCAGGTAA	0.393													3	7					0	0	0.004672	0	0
ABCA8	10351	broad.mit.edu	37	17	66925360	66925360	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:66925360A>G	uc002jhp.2	-	8	1134	c.955T>C	c.(955-957)TTA>CTA	p.L319L	ABCA8_uc002jhq.2_Silent_p.L319L|ABCA8_uc010wqq.1_Silent_p.L319L|ABCA8_uc010wqr.1_Silent_p.L258L|ABCA8_uc002jhr.2_Silent_p.L319L	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	319	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					ATGCTCATTAAGAAAGCCAAA	0.373													17	17					0	0	0.004990	0	0
FADS6	283985	broad.mit.edu	37	17	72875693	72875693	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:72875693G>A	uc002jmd.1	-	5	759	c.747C>T	c.(745-747)TTC>TTT	p.F249F	FADS6_uc010wrn.1_Silent_p.F103F	NM_178128	NP_835229	Q8N9I5	FADS6_HUMAN	fatty acid desaturase domain family, member 6	255					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity				0	all_lung(278;0.172)|Lung NSC(278;0.207)					TGTCCCGGGAGAACATGGGCA	0.652													8	18					0	0	0.006214	0	0
UNK	85451	broad.mit.edu	37	17	73805988	73805988	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:73805988C>T	uc002jpm.2	+	3	480	c.480C>T	c.(478-480)TAC>TAT	p.Y160Y		NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	84	C3H1-type 1.						nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCTTCAATTACAGCCCTGACG	0.642													40	24					0	0	0.007835	0	0
WBP2	23558	broad.mit.edu	37	17	73844682	73844682	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:73844682G>A	uc002jps.2	-	4	489	c.366C>T	c.(364-366)TTC>TTT	p.F122F	WBP2_uc002jpr.2_Silent_p.F88F|WBP2_uc010wsl.1_Silent_p.F88F|WBP2_uc002jpt.2_Silent_p.F122F|WBP2_uc002jpu.1_RNA|WBP2_uc010wsm.1_Silent_p.F122F|WBP2_uc010wsn.1_Intron	NM_012478	NP_036610	Q969T9	WBP2_HUMAN	WW domain binding protein 2	122							protein binding				0			all cancers(21;2.61e-06)|Epithelial(20;2.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCGCTGTCCGAACTCAATGG	0.512											OREG0024743	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	18					0	0	0.000978	0	0
TRIM65	201292	broad.mit.edu	37	17	73888544	73888544	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:73888544T>C	uc002jpx.2	-	3	584	c.548A>G	c.(547-549)AAG>AGG	p.K183R		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	183	Potential.					intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTGCTGAACTTGCCGGAGAC	0.642													44	21					0	0	0.003610	0	0
ACOX1	51	broad.mit.edu	37	17	73945587	73945587	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:73945587G>A	uc002jqf.2	-	11	1863	c.1573C>T	c.(1573-1575)CGA>TGA	p.R525*	ACOX1_uc010wsq.1_Nonsense_Mutation_p.R487*|ACOX1_uc002jqe.2_Nonsense_Mutation_p.R525*|ACOX1_uc010wsr.1_Nonsense_Mutation_p.R457*	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	525					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1						TCACTTGCTCGAACAAGGTCA	0.423													15	72					0	0	0.003163	0	0
EVPL	2125	broad.mit.edu	37	17	74015056	74015056	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:74015056C>T	uc002jqi.2	-	11	1451	c.1223G>A	c.(1222-1224)CGA>CAA	p.R408Q	EVPL_uc010wss.1_Missense_Mutation_p.R408Q|EVPL_uc010wst.1_5'UTR	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	408	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						GGGGTTTCTTCGCTGTGGCAG	0.682													21	11					0	0	0.001882	0	0
SRP68	6730	broad.mit.edu	37	17	74046528	74046528	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:74046528T>C	uc002jqk.1	-	9	1093	c.1058A>G	c.(1057-1059)GAG>GGG	p.E353G	SRP68_uc010wsu.1_Missense_Mutation_p.E252G|SRP68_uc002jql.1_Missense_Mutation_p.E315G|SRP68_uc002jqj.1_Missense_Mutation_p.E14G	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	353					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						CTTGAGCTCCTCCCGAACCAC	0.582													3	100					0	0	0.000248	0	0
DNAH17	8632	broad.mit.edu	37	17	76457737	76457737	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:76457737C>T	uc010dhp.1	-	3	450	c.228G>A	c.(226-228)AAG>AAA	p.K76K	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CGCTCTCATTCTTCTGCTTGA	0.557													8	14					0	0	0.003080	0	0
DNAH17	8632	broad.mit.edu	37	17	76503785	76503785	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:76503785C>T	uc010wtu.1	-	2	391	c.214G>A	c.(214-216)GAG>AAG	p.E72K						full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCCAGCGTCTCCACCAGCACC	0.592													3	9					0	0	0.000248	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77043683	77043684	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:77043683_77043684GG>AA	uc002jwp.2	+	4	699_700	c.359_360GG>AA	c.(358-360)GGG>GAA	p.G120E	C1QTNF1_uc002jwq.2_Missense_Mutation_p.G38E|C1QTNF1_uc002jwr.3_Missense_Mutation_p.G130E|C1QTNF1_uc002jws.2_Missense_Mutation_p.G120E|C1QTNF1_uc002jwt.2_Missense_Mutation_p.G218E	NM_030968	NP_112230	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	120	Collagen-like.					collagen				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			GGCTCAGCAGGGGCCAGGGGCC	0.624													56	37					0	0	0.004672	0	0
ENPP7	339221	broad.mit.edu	37	17	77705076	77705076	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:77705076C>T	uc002jxa.2	+	1	195	c.175C>T	c.(175-177)CGA>TGA	p.R59*		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	59					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CGCCATGGCCCGAGACGGGGT	0.632													17	27					0	0	0.004990	0	0
EIF4A3	9775	broad.mit.edu	37	17	78120709	78120709	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:78120709G>A	uc010wuc.1	-	2	125	c.52C>T	c.(52-54)CTC>TTC	p.L18F	EIF4A3_uc002jxs.2_Missense_Mutation_p.L18F	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	18					mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			TCCTCTTTGAGCAGCCGCTTT	0.572													10	23					0	0	0.008291	0	0
TMEM105	284186	broad.mit.edu	37	17	79287651	79287651	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:79287651G>A	uc002kad.1	-	3	740	c.190C>T	c.(190-192)CCT>TCT	p.P64S		NM_178520	NP_848615	Q8N8V8	TM105_HUMAN	transmembrane protein 105	64						integral to membrane				ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			TCCCCCCAAGGAGACCGAGGT	0.622													57	33					0	0	0.003610	0	0
MYOM1	8736	broad.mit.edu	37	18	3141961	3141961	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:3141961C>T	uc002klp.2	-	14	2335	c.2001G>A	c.(1999-2001)GAG>GAA	p.E667E	MYOM1_uc002klq.2_Silent_p.E667E	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	667	Fibronectin type-III 2.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						ACATAATGCCCTCATGACCAC	0.517													36	88					0	0	0.006230	0	0
RALBP1	10928	broad.mit.edu	37	18	9533743	9533743	+	Silent	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:9533743C>A	uc002kob.2	+	9	1843	c.1620C>A	c.(1618-1620)TCC>TCA	p.S540S	RALBP1_uc002koc.2_Silent_p.S540S	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	540					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1						AGTACTCCTCCGAGAGCGAGA	0.527													25	53					2.24059e-21	3.42727e-21	0.006320	1	0
TXNDC2	84203	broad.mit.edu	37	18	9887778	9887778	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:9887778C>T	uc002koi.3	+	2	1751	c.1302C>T	c.(1300-1302)ATC>ATT	p.I434I	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Silent_p.I367I	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	434	Thioredoxin.|22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.|22.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						AGGGTGACATCCTAAAGCCTG	0.547													9	40					0	0	0.004482	0	0
TTC39C	125488	broad.mit.edu	37	18	21703897	21703897	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:21703897C>T	uc002kuw.2	+	9	1738	c.1286C>T	c.(1285-1287)TCG>TTG	p.S429L	TTC39C_uc002kuu.2_Missense_Mutation_p.S368L	NM_001135993	NP_001129465	Q8N584	TT39C_HUMAN	tetratricopeptide repeat domain 39C isoform 1	429							binding			ovary(1)	1						GAACAGTTCTCGGTGAAAAAG	0.398													8	7					0	0	0.004482	0	0
DSC3	1825	broad.mit.edu	37	18	28598186	28598187	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:28598186_28598187CC>TT	uc002kwj.3	-	9	1268_1269	c.1113_1114GG>AA	c.(1111-1116)GTGGAA>GTAAAA	p.E372K	DSC3_uc002kwi.3_Missense_Mutation_p.E372K	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	372	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CGTAAGATTTCCACATTGAATG	0.272													10	30					0	0	0.004672	0	0
DSC3	1825	broad.mit.edu	37	18	28609528	28609528	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:28609528G>T	uc002kwj.3	-	4	576	c.421C>A	c.(421-423)CCT>ACT	p.P141T	DSC3_uc002kwi.3_Missense_Mutation_p.P141T	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	141	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			ATAGAGCAAGGAATAGGTGCC	0.413													31	47					2.49991e-28	3.83092e-28	0.003271	1	0
DSC1	1823	broad.mit.edu	37	18	28719835	28719835	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:28719835A>C	uc002kwn.2	-	11	1801	c.1539T>G	c.(1537-1539)GAT>GAG	p.D513E	DSC1_uc002kwm.2_Missense_Mutation_p.D513E	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	513	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			AGTTATCTTCATCCCCTAACT	0.299													12	23					0	0	0.002450	0	0
DSG4	147409	broad.mit.edu	37	18	28992958	28992958	+	Silent	SNP	G	A	A	rs151048983		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:28992958G>A	uc002kwq.2	+	16	2658	c.2523G>A	c.(2521-2523)AGG>AGA	p.R841R	DSG4_uc002kwr.2_Silent_p.R860R	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	841	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAAAATTTAGGACTCTTGCTG	0.443													30	34					0	0	0.008361	0	0
DSG3	1830	broad.mit.edu	37	18	29046600	29046601	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:29046600_29046601CC>TT	uc002kws.2	+	11	1628_1629	c.1519_1520CC>TT	c.(1519-1521)CCT>TTT	p.P507F		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	507	Extracellular (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAGTTCTTCACCTTCCGTGGTT	0.446													35	55					0	0	0.004672	0	0
DSG3	1830	broad.mit.edu	37	18	29054213	29054213	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:29054213G>A	uc002kws.2	+	15	2340	c.2231G>A	c.(2230-2232)GGA>GAA	p.G744E	DSG3_uc002kwt.2_Missense_Mutation_p.G26E	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	744	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACAGTGTCAGGAGCTGCTTCA	0.537													15	25					0	0	0.002450	0	0
DSG3	1830	broad.mit.edu	37	18	29055678	29055678	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:29055678G>A	uc002kws.2	+	16	2564	c.2455G>A	c.(2455-2457)GAA>AAA	p.E819K	DSG3_uc002kwt.2_Missense_Mutation_p.E101K	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	819	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTATGATAATGAAGGCGCAGA	0.473													23	37					0	0	0.003330	0	0
WBP11P1	441818	broad.mit.edu	37	18	30091802	30091802	+	RNA	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:30091802T>G	uc010dmc.2	+	1		c.177T>G				NR_003558				Homo sapiens cDNA clone IMAGE:5265376, partial cds.												0						AATGAACAAGTAAACCATACA	0.418													25	25					0	0	0.003330	0	0
ASXL3	80816	broad.mit.edu	37	18	31325147	31325147	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:31325147C>T	uc010dmg.1	+	12	5390	c.5335C>T	c.(5335-5337)CCA>TCA	p.P1779S	ASXL3_uc002kxq.2_Missense_Mutation_p.P1486S	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CAACAGGCTTCCATTGCCTCT	0.498													26	20					0	0	0.004656	0	0
DTNA	1837	broad.mit.edu	37	18	32462040	32462040	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:32462040G>A	uc010dmn.1	+	20	2090	c.2089G>A	c.(2089-2091)GAG>AAG	p.E697K	DTNA_uc002kxw.2_Missense_Mutation_p.E640K|DTNA_uc010dmj.2_Missense_Mutation_p.E637K|DTNA_uc002kxz.2_Missense_Mutation_p.E644K|DTNA_uc002kxy.2_Missense_Mutation_p.E637K|DTNA_uc010xby.1_Missense_Mutation_p.E387K|DTNA_uc010xbz.1_Missense_Mutation_p.E406K|DTNA_uc010xca.1_Missense_Mutation_p.E349K|DTNA_uc002kye.2_Missense_Mutation_p.E345K	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	697					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						CAGGGTTACGGAGGATGCAGA	0.438													18	24					0	0	0.001523	0	0
FHOD3	80206	broad.mit.edu	37	18	34335241	34335241	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:34335241G>A	uc002kzt.1	+	21	3913	c.3816G>A	c.(3814-3816)GAG>GAA	p.E1272E	FHOD3_uc002kzs.1_Silent_p.E1289E|FHOD3_uc010dmz.1_Silent_p.E1004E|FHOD3_uc010dnb.1_Silent_p.E268E	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	1272	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				ACCACAGAGAGAGAAATAAGA	0.423													7	8					0	0	0.003080	0	0
CELF4	56853	broad.mit.edu	37	18	34846537	34846537	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:34846537G>A	uc002lae.2	-	9	1520	c.1124C>T	c.(1123-1125)CCC>CTC	p.P375L	CELF4_uc010dnd.1_Missense_Mutation_p.P373L|CELF4_uc002lag.2_Missense_Mutation_p.P365L|CELF4_uc002laf.2_Missense_Mutation_p.P370L|CELF4_uc002lai.2_Missense_Mutation_p.P360L|CELF4_uc002lah.1_Missense_Mutation_p.P100L	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	375					embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						CTGCTGCAGGGGGTCCGCGGC	0.647													3	2					0	0	0.000248	0	0
ATP5A1	498	broad.mit.edu	37	18	43667373	43667373	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:43667373G>A	uc002lbr.1	-	7	975	c.885C>T	c.(883-885)TCC>TCT	p.S295S	ATP5A1_uc010dnl.1_Silent_p.S245S|ATP5A1_uc002lbs.1_Silent_p.S245S|ATP5A1_uc002lbt.1_Silent_p.S295S	NM_004046	NP_004037	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	295					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism				0						ACTCTCCCATGGAACAGCCAG	0.418													28	19					0	0	0.002445	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555073	44555073	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:44555073C>T	uc010xdb.1	-	1	1377	c.1141G>A	c.(1141-1143)GAC>AAC	p.D381N	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	381	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						GCGGCATTGTCTTTCTCTGTG	0.572													15	803					0	0	0.004990	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560546	44560546	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:44560546G>A	uc002lcr.1	-	1	1443	c.1090C>T	c.(1090-1092)CTC>TTC	p.L364F	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	364					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						ACCTCAGAGAGGGAGCTCACG	0.542													31	35					0	0	0.002836	0	0
MYO5B	4645	broad.mit.edu	37	18	47500984	47500984	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:47500984G>A	uc002leb.2	-	10	1346	c.1058C>T	c.(1057-1059)CCC>CTC	p.P353L	MYO5B_uc002lec.1_Missense_Mutation_p.P352L	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	353	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TACATCCTGGGGCTGTGGGAG	0.587													20	31					0	0	0.001882	0	0
CXXC1	30827	broad.mit.edu	37	18	47813150	47813150	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:47813150A>G	uc002leq.3	-	2	815	c.82T>C	c.(82-84)TAC>CAC	p.Y28H	CXXC1_uc002lep.3_5'UTR|CXXC1_uc002ler.3_Missense_Mutation_p.Y28H|CXXC1_uc010doy.2_Missense_Mutation_p.Y28H|CXXC1_uc002les.2_Missense_Mutation_p.Y28H	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	28	PHD-type.				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CAGATGCAGTAGATGGGCGCA	0.627													21	40					0	0	0.002299	0	0
RAB27B	5874	broad.mit.edu	37	18	52556515	52556515	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:52556515C>T	uc002lfr.2	+	6	639	c.528C>T	c.(526-528)ACC>ACT	p.T176T		NM_004163	NP_004154	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	176					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity				0				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		CTGTAGAAACCCTTTTGGACT	0.403													13	17					0	0	0.004007	0	0
ONECUT2	9480	broad.mit.edu	37	18	55103457	55103457	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:55103457C>T	uc002lgo.2	+	1	541	c.509C>T	c.(508-510)CCT>CTT	p.P170L		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	170	Poly-His.				organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		TTccaccaccctcacccgcac	0.483													3	5					0	0	0.004672	0	0
CCBE1	147372	broad.mit.edu	37	18	57103244	57103244	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:57103244C>T	uc002lib.2	-	11	1187	c.1117G>A	c.(1117-1119)GAA>AAA	p.E373K	CCBE1_uc010dpq.2_Missense_Mutation_p.E102K|CCBE1_uc002lia.2_Missense_Mutation_p.E226K	NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	373					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				CTGGGAAATTCCTGAGGTAAA	0.532													50	68					0	0	0.003610	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323156	61323156	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:61323156C>T	uc002lji.2	-	8	1052	c.908G>A	c.(907-909)GGA>GAA	p.G303E	SERPINB4_uc002ljg.2_Intron|SERPINB3_uc010dqa.2_Missense_Mutation_p.G251E	NM_006919	NP_008850	P29508	SPB3_HUMAN	serine (or cysteine) proteinase inhibitor, clade	303					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ATCCACCATTCCCATGGTTCT	0.502													25	46					0	0	0.008361	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323175	61323175	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:61323175C>T	uc002lji.2	-	8	1033	c.889G>A	c.(889-891)GAC>AAC	p.D297N	SERPINB4_uc002ljg.2_Intron|SERPINB3_uc010dqa.2_Missense_Mutation_p.D245N	NM_006919	NP_008850	P29508	SPB3_HUMAN	serine (or cysteine) proteinase inhibitor, clade	297					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CTCAACGTGTCCTTGAGGTCA	0.488													31	35					0	0	0.003755	0	0
DOK6	220164	broad.mit.edu	37	18	67406248	67406248	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:67406248G>A	uc002lkl.2	+	6	837	c.647G>A	c.(646-648)GGA>GAA	p.G216E		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	216	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				ACAAGGGAAGGAGAAATGATC	0.443													40	59					0	0	0.007835	0	0
CBLN2	147381	broad.mit.edu	37	18	70205894	70205894	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:70205894G>A	uc002lku.2	-	3	706	c.471C>T	c.(469-471)ACC>ACT	p.T157T	CBLN2_uc002lkv.2_Silent_p.T157T	NM_182511	NP_872317	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	157	C1q.					integral to membrane					0		Esophageal squamous(42;0.131)				CCACCTGGATGGTTTGTCTGT	0.453													16	36					0	0	0.007413	0	0
MIER2	54531	broad.mit.edu	37	19	312226	312226	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:312226A>T	uc002lok.1	-	9	863	c.854T>A	c.(853-855)CTG>CAG	p.L285Q		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	285	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCCTTCGCAGGGCCTCCTC	0.632													4	14					0	0	0.001168	0	0
C19orf21	126353	broad.mit.edu	37	19	757283	757283	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:757283C>T	uc002lpo.2	+	2	420	c.337C>T	c.(337-339)CCA>TCA	p.P113S		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	113										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCACTCCGCCCAGAGGACGG	0.672													13	15					0	0	0.001855	0	0
POLR2E	5434	broad.mit.edu	37	19	1091854	1091854	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:1091854C>T	uc002lre.3	-	3	362	c.285G>A	c.(283-285)CAG>CAA	p.Q95Q	POLR2E_uc010xgf.1_RNA	NM_002695	NP_002686	P19388	RPAB1_HUMAN	DNA directed RNA polymerase II polypeptide E	95					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTTCTCCTCCTGCATGCGCT	0.662													24	27					0	0	0.003954	0	0
JSRP1	126306	broad.mit.edu	37	19	2252382	2252382	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:2252382C>T	uc002lvi.1	-	6	977	c.942G>A	c.(940-942)GAG>GAA	p.E314E	JSRP1_uc002lvj.1_Silent_p.E314E	NM_144616	NP_653217	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	314	Arg-rich.					sarcoplasmic reticulum membrane				pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGCTGCTCCTCGTCGGGAC	0.761													5	3					0	0	0.000602	0	0
ZNF555	148254	broad.mit.edu	37	19	2852712	2852712	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:2852712C>T	uc002lwo.2	+	4	738	c.649C>T	c.(649-651)CGG>TGG	p.R217W	ZNF555_uc002lwn.3_Missense_Mutation_p.R216W	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	217	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCCTCAATCGGCATGTAAG	0.428													22	29					0	0	0.002299	0	0
ZNF555	148254	broad.mit.edu	37	19	2853905	2853905	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:2853905G>A	uc002lwo.2	+	4	1931	c.1842G>A	c.(1840-1842)CAG>CAA	p.Q614Q	ZNF555_uc002lwn.3_Silent_p.Q613Q	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	614					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCACACCAGGAGAGAGATC	0.378													29	24					0	0	0.006320	0	0
PLIN4	729359	broad.mit.edu	37	19	4510756	4510756	+	Silent	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:4510756G>T	uc002mar.1	-	3	3174	c.3174C>A	c.(3172-3174)ACC>ACA	p.T1058T	PLIN4_uc010dub.1_Silent_p.T82T	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	1058						lipid particle|plasma membrane					0						CATTGTCTGTGGTCCTGGAAC	0.652													14	15					0.000422831	0.000639487	0.004007	1	0
LRG1	116844	broad.mit.edu	37	19	4538435	4538435	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:4538435G>A	uc002mau.2	-	2	572	c.561C>T	c.(559-561)TTC>TTT	p.F187F	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	187						extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGGAGGGTGAAGTTGGCCA	0.617													52	81					0	0	0.003610	0	0
PLIN3	10226	broad.mit.edu	37	19	4859643	4859643	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:4859643A>G	uc002mbj.2	-	4	484	c.307T>C	c.(307-309)TTG>CTG	p.L103L	PLIN3_uc002mbk.2_Silent_p.L103L|PLIN3_uc002mbl.3_Silent_p.L103L	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	103					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	TTCTCCTCCAACTTGTCCAGC	0.562													15	19					0	0	0.004007	0	0
LONP1	9361	broad.mit.edu	37	19	5719871	5719871	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:5719871C>T	uc002mcx.2	-	1	306	c.273G>A	c.(271-273)GAG>GAA	p.E91E	TMEM146_uc010duj.1_5'Flank|TMEM146_uc002mda.2_5'Flank|LONP1_uc002mcy.2_Intron|LONP1_uc010duh.2_5'UTR|LONP1_uc010dui.2_Silent_p.E91E|LONP1_uc002mcz.2_Intron	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	91					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						cggcTCCTTCCTCCGCGCCGC	0.582													3	3					0	0	0.004672	0	0
TMEM146	257062	broad.mit.edu	37	19	5746029	5746029	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:5746029C>T	uc002mda.2	+	9	824	c.763C>T	c.(763-765)CTG>TTG	p.L255L	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	255	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						GAGAGGCATCCTGCTCCTATG	0.587													69	64					0	0	0.003610	0	0
ALKBH7	84266	broad.mit.edu	37	19	6374273	6374273	+	Silent	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:6374273C>A	uc002meo.1	+	2	652	c.264C>A	c.(262-264)ATC>ATA	p.I88I		NM_032306	NP_115682	Q9BT30	ALKB7_HUMAN	spermatogenesis associated 11 precursor	88						extracellular region|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GCCGGGCCATCCTGCAGCGCG	0.682													18	18					3.51602e-12	5.35622e-12	0.008871	1	0
DENND1C	79958	broad.mit.edu	37	19	6468102	6468102	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:6468102C>T	uc002mfe.2	-	23	1911	c.1819G>A	c.(1819-1821)GAT>AAT	p.D607N	DENND1C_uc002mfb.2_Missense_Mutation_p.D157N|DENND1C_uc002mfc.2_Missense_Mutation_p.D157N|DENND1C_uc002mfd.2_Missense_Mutation_p.D157N|DENND1C_uc010xje.1_Missense_Mutation_p.D563N	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	607						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						AGTTTCTTATCGTCTGGTTGC	0.542													15	22					0	0	0.006122	0	0
GPR108	56927	broad.mit.edu	37	19	6732361	6732361	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:6732361G>A	uc002mfp.2	-	12	1084	c.1038C>T	c.(1036-1038)ATC>ATT	p.I346I	GPR108_uc010duv.2_5'Flank|GPR108_uc002mfn.2_Silent_p.I17I|GPR108_uc002mfo.3_Silent_p.I104I|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	346	Helical; Name=3; (Potential).					integral to membrane					0						CAATCAGGGCGATGGTGATGA	0.622													17	33					0	0	0.007413	0	0
EMR1	2015	broad.mit.edu	37	19	6908774	6908774	+	Silent	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:6908774T>A	uc002mfw.2	+	10	1151	c.1113T>A	c.(1111-1113)GTT>GTA	p.V371V	EMR1_uc010dvc.2_Silent_p.V371V|EMR1_uc010dvb.2_Silent_p.V319V|EMR1_uc010xji.1_Silent_p.V230V|EMR1_uc010xjj.1_Silent_p.V194V	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	371	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					CGACCGTAGTTTCTCTGAAGG	0.348													24	29					0	0	0.003330	0	0
INSR	3643	broad.mit.edu	37	19	7120643	7120643	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:7120643G>A	uc002mgd.1	-	20	3756	c.3647C>T	c.(3646-3648)TCT>TTT	p.S1216F	INSR_uc002mge.1_Missense_Mutation_p.S1204F	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1216	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CATGTCAGAAGAAGTGGTGAA	0.562													64	102					0	0	0.003610	0	0
TRAPPC5	126003	broad.mit.edu	37	19	7747303	7747303	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:7747303C>T	uc002mhi.1	+	2	234	c.164C>T	c.(163-165)GCC>GTC	p.A55V	TRAPPC5_uc002mhj.1_Missense_Mutation_p.A55V|TRAPPC5_uc002mhk.1_Missense_Mutation_p.A55V	NM_001042462	NP_001035927	Q8IUR0	TPPC5_HUMAN	trafficking protein particle complex 5	55					vesicle-mediated transport	endoplasmic reticulum	guanylate cyclase activity|heme binding				0						TCGCGCCTGGCCGCGCTGGGC	0.701													3	0					0	0	0.004672	0	0
FBN3	84467	broad.mit.edu	37	19	8156470	8156470	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:8156470G>A	uc002mjf.2	-	47	5931	c.5910C>T	c.(5908-5910)ATC>ATT	p.I1970I	FBN3_uc002mje.2_5'Flank	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1970	EGF-like 32; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						AGCACTCGTCGATATCTGGAA	0.602													21	22					0	0	0.002299	0	0
ACTL9	284382	broad.mit.edu	37	19	8808449	8808449	+	Silent	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:8808449C>A	uc002mkl.2	-	1	724	c.603G>T	c.(601-603)GGG>GGT	p.G201G		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	201						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						TGTAGGTGACCCCGTGTCCCG	0.667													11	18					1.58986e-06	2.41648e-06	0.008291	1	0
ZNF558	148156	broad.mit.edu	37	19	8931904	8931904	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:8931904G>A	uc002mkn.1	-	3	429	c.199C>T	c.(199-201)CTG>TTG	p.L67L	ZNF558_uc010xkh.1_5'UTR|ZNF558_uc010dwg.1_Silent_p.L67L	NM_144693	NP_653294	Q96NG5	ZN558_HUMAN	zinc finger protein 558	67	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1						TCCCTGTACAGTGTCCTTTGG	0.517													20	19					0	0	0.008871	0	0
MUC16	94025	broad.mit.edu	37	19	9049258	9049258	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9049258C>T	uc002mkp.2	-	5	32577	c.32373G>A	c.(32371-32373)CGG>CGA	p.R10791R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10793	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTCACCAACCGTGATACAG	0.493													43	62					0	0	0.002522	0	0
MUC16	94025	broad.mit.edu	37	19	9059045	9059045	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9059045G>A	uc002mkp.2	-	3	28605	c.28401C>T	c.(28399-28401)TTC>TTT	p.F9467F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9469	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGATAGAGGTGAAAAGAGAAG	0.478													40	51					0	0	0.005524	0	0
MUC16	94025	broad.mit.edu	37	19	9060492	9060492	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9060492G>A	uc002mkp.2	-	3	27158	c.26954C>T	c.(26953-26955)GCT>GTT	p.A8985V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8987	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTCAGAGGAAGCAGGTATGGT	0.498													62	84					0	0	0.003610	0	0
MUC16	94025	broad.mit.edu	37	19	9060867	9060867	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9060867G>A	uc002mkp.2	-	3	26783	c.26579C>T	c.(26578-26580)TCT>TTT	p.S8860F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8862	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTTACTGCAGATAAAGACAC	0.517													38	41					0	0	0.007835	0	0
MUC16	94025	broad.mit.edu	37	19	9061543	9061543	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9061543C>T	uc002mkp.2	-	3	26107	c.25903G>A	c.(25903-25905)GAT>AAT	p.D8635N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8637	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCTCTCTATCTTTGGTGACT	0.438													24	27					0	0	0.003330	0	0
MUC16	94025	broad.mit.edu	37	19	9062833	9062833	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9062833C>T	uc002mkp.2	-	3	24817	c.24613G>A	c.(24613-24615)GAT>AAT	p.D8205N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8207	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCAGGAGGATCTGTTTGTGTC	0.468													16	18					0	0	0.007413	0	0
MUC16	94025	broad.mit.edu	37	19	9066587	9066587	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9066587C>T	uc002mkp.2	-	3	21063	c.20859G>A	c.(20857-20859)CTG>CTA	p.L6953L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6955	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTCTCTCTCAGTCCAGGAG	0.458													48	64					0	0	0.003214	0	0
MUC16	94025	broad.mit.edu	37	19	9068506	9068506	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9068506C>T	uc002mkp.2	-	3	19144	c.18940G>A	c.(18940-18942)GAA>AAA	p.E6314K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6316	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAATAGAATTCATTTGGTGAA	0.463													21	57					0	0	0.001882	0	0
MUC16	94025	broad.mit.edu	37	19	9077116	9077116	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9077116G>A	uc002mkp.2	-	3	10534	c.10330C>T	c.(10330-10332)CCT>TCT	p.P3444S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3445	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGACATCAGGAGATGCACCA	0.478													28	44					0	0	0.004656	0	0
MUC16	94025	broad.mit.edu	37	19	9077817	9077817	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9077817C>T	uc002mkp.2	-	3	9833	c.9629G>A	c.(9628-9630)AGC>AAC	p.S3210N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3211	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCCTTGGAGCTCATGATTTT	0.468													55	55					0	0	0.003610	0	0
MUC16	94025	broad.mit.edu	37	19	9082689	9082689	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9082689G>A	uc002mkp.2	-	1	9330	c.9126C>T	c.(9124-9126)TTC>TTT	p.F3042F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3043	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGGGGAAAGGAAGCTTGTTT	0.483													26	52					0	0	0.003954	0	0
MUC16	94025	broad.mit.edu	37	19	9083324	9083324	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9083324C>T	uc002mkp.2	-	1	8695	c.8491G>A	c.(8491-8493)GAA>AAA	p.E2831K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2831	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGTGATTTCAGACATGGCT	0.507													8	8					0	0	0.006214	0	0
MUC16	94025	broad.mit.edu	37	19	9086712	9086712	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9086712G>A	uc002mkp.2	-	1	5307	c.5103C>T	c.(5101-5103)TCC>TCT	p.S1701S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1701	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAAGGACAGAGGAAACTCTTC	0.488													53	66					0	0	0.003610	0	0
MUC16	94025	broad.mit.edu	37	19	9090331	9090331	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9090331G>A	uc002mkp.2	-	1	1688	c.1484C>T	c.(1483-1485)TCC>TTC	p.S495F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	495	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCTGTGCTGGAACTCTGCCT	0.532													34	30					0	0	0.004289	0	0
OR7G2	390882	broad.mit.edu	37	19	9213450	9213450	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9213450A>T	uc010xkk.1	-	1	533	c.533T>A	c.(532-534)CTT>CAT	p.L178H		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCTGAGAAGAAGGGCATTCAC	0.517													11	15					0	0	0.000978	0	0
OR7D2	162998	broad.mit.edu	37	19	9297116	9297116	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9297116G>A	uc002mkz.1	+	1	847	c.659G>A	c.(658-660)CGA>CAA	p.R220Q		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	220	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						TCTTATTCACGAATTGCTTCA	0.463													25	30					0	0	0.003954	0	0
RAVER1	125950	broad.mit.edu	37	19	10444150	10444151	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:10444150_10444151GG>AA	uc002moa.2	-	1	164_165	c.84_85CC>TT	c.(82-87)CCCCCG>CCTTCG	p.P29S		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	12						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			GGGCTCAGCGGGGGCCGGTGAG	0.698													17	21					0	0	0.004672	0	0
QTRT1	81890	broad.mit.edu	37	19	10823826	10823826	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:10823826C>T	uc002mpr.2	+	10	1117	c.1092C>T	c.(1090-1092)ATC>ATT	p.I364I	DNM2_uc010dxk.2_RNA	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	364					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			GCACCAGCATCGTGGAGAAGC	0.687													19	29					0	0	0.008871	0	0
ZNF443	10224	broad.mit.edu	37	19	12541577	12541578	+	Missense_Mutation	DNP	GT	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:12541577_12541578GT>AA	uc002mtu.2	-	4	1606_1607	c.1408_1409AC>TT	c.(1408-1410)ACT>TTT	p.T470F		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	470	C2H2-type 12.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						TCCAGTATGAGTTGTTTCATGC	0.406													17	24					0	0	0.004672	0	0
TRMT1	55621	broad.mit.edu	37	19	13220601	13220601	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:13220601G>A	uc002mwj.2	-	9	1408	c.1158C>T	c.(1156-1158)CAC>CAT	p.H386H	TRMT1_uc010xmy.1_5'Flank|TRMT1_uc002mwk.2_Silent_p.H357H|TRMT1_uc002mwl.3_Silent_p.H386H|TRMT1_uc010xmz.1_Silent_p.H172H	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	386							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		GTTGCCCACAGTGTTCACACT	0.627													15	30					0	0	0.004990	0	0
CACNA1A	773	broad.mit.edu	37	19	13443705	13443705	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:13443705C>T	uc010dze.2	-	9	1469	c.1233G>A	c.(1231-1233)GGG>GGA	p.G411G	CACNA1A_uc010dzc.2_5'Flank|CACNA1A_uc002mwy.3_Silent_p.G411G|CACNA1A_uc010xne.1_5'Flank	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	411	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCCTCTGCTCCCCGTCAGTTT	0.567													8	16					0	0	0.006214	0	0
CACNA1A	773	broad.mit.edu	37	19	13446673	13446673	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:13446673G>A	uc010dze.2	-	7	1265	c.1029C>T	c.(1027-1029)CTC>CTT	p.L343L	CACNA1A_uc002mwy.3_Silent_p.L343L	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	343	I.|Helical; Name=S6 of repeat I; (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGATGATGATGAGGGGGATGA	0.522													4	6					0	0	0.001168	0	0
AKAP8L	26993	broad.mit.edu	37	19	15512027	15512027	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:15512027G>A	uc002naw.1	-	5	849	c.750C>T	c.(748-750)TTC>TTT	p.F250F	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Silent_p.F189F|AKAP8L_uc002nay.1_Silent_p.F250F|AKAP8L_uc002naz.2_Silent_p.F98F	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	250						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						TGCCAAACCCGAAACCAAAGC	0.632													71	71					0	0	0.003610	0	0
OR10H5	284433	broad.mit.edu	37	19	15905792	15905792	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:15905792C>T	uc010xos.1	+	1	934	c.934C>T	c.(934-936)CCA>TCA	p.P312S		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CAAACTCTTTCCACAGAACTG	0.438													10	9					0	0	0.008291	0	0
OR10H4	126541	broad.mit.edu	37	19	16060708	16060708	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:16060708G>A	uc010xov.1	+	1	891	c.891G>A	c.(889-891)AAG>AAA	p.K297K		NM_001004465	NP_001004465	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TAAGGAACAAGGAGCTGAAGA	0.433													49	52					0	0	0.003610	0	0
C19orf44	84167	broad.mit.edu	37	19	16613942	16613942	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:16613942A>C	uc002neh.1	+	3	899	c.826A>C	c.(826-828)ACA>CCA	p.T276P	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.T276P|C19orf44_uc002neg.2_Missense_Mutation_p.T276P|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	276											0						GCCTTCTCAGACATCACACCT	0.502													26	30					0	0	0.008361	0	0
NWD1	284434	broad.mit.edu	37	19	16875870	16875870	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:16875870G>A	uc002neu.3	+	10	2699	c.2277G>A	c.(2275-2277)CGG>CGA	p.R759R	NWD1_uc002net.3_Silent_p.R624R|NWD1_uc002nev.3_Silent_p.R553R			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	759							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						TTTCCTGCCGGGGCATCTCTG	0.607													19	14					0	0	0.002780	0	0
FCHO1	23149	broad.mit.edu	37	19	17881307	17881307	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:17881307C>T	uc010ebb.2	+	7	599	c.410C>T	c.(409-411)TCC>TTC	p.S137F	FCHO1_uc002nhg.3_Missense_Mutation_p.S137F|FCHO1_uc002nhh.2_Missense_Mutation_p.S137F|FCHO1_uc010xpw.1_Missense_Mutation_p.S87F|FCHO1_uc010ebc.1_Missense_Mutation_p.S144F	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	137										breast(1)	1						CTGCCCAAGTCCCGCGAGAAC	0.622													13	20					0	0	0.001368	0	0
TM6SF2	53345	broad.mit.edu	37	19	19377355	19377355	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:19377355G>A	uc002nmd.1	-	9	918	c.868C>T	c.(868-870)CCT>TCT	p.P290S	HAPLN4_uc002nmc.2_5'UTR	NM_001001524	NP_001001524	Q9BZW4	TM6S2_HUMAN	transmembrane 6 superfamily member 2	290						integral to membrane					0			Epithelial(12;0.0151)			GAGCAACCAGGGAAGGTGAGA	0.612													21	25					0	0	0.008871	0	0
ZNF14	7561	broad.mit.edu	37	19	19822584	19822584	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:19822584G>A	uc002nnk.1	-	4	1660	c.1506C>T	c.(1504-1506)CCC>CCT	p.P502P		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	502					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				TACATTCATAGGGTTTCTCTC	0.383													25	38					0	0	0.003954	0	0
ZNF90	7643	broad.mit.edu	37	19	20235900	20235900	+	RNA	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:20235900G>A	uc002nos.1	+	5		c.576G>A			ZNF90_uc002not.1_RNA			Q03938	ZNF90_HUMAN	Synthetic construct DNA, clone: pF1KB9685, Homo sapiens ZNF90 gene for zinc finger protein 90, without stop codon, in Flexi system.							Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCGGACGCAAGAAGACAGCCA	0.622													6	2					0	0	0.001168	0	0
ZNF676	163223	broad.mit.edu	37	19	22363276	22363276	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:22363276G>A	uc002nqs.1	-	3	1561	c.1243C>T	c.(1243-1245)CAT>TAT	p.H415Y		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	415	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TCTCCAGTATGAATTCTCTTA	0.433													21	23					0	0	0.003954	0	0
ZNF676	163223	broad.mit.edu	37	19	22363614	22363614	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:22363614A>G	uc002nqs.1	-	3	1223	c.905T>C	c.(904-906)ATT>ACT	p.I302T		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	302	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TCCAGTATGAATTCTCTTATG	0.428													17	32					0	0	0.001523	0	0
ZNF99	7652	broad.mit.edu	37	19	22951111	22951111	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:22951111G>A	uc010xrh.1	-	3	285	c.285C>T	c.(283-285)CCC>CCT	p.P95P		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACATACCTGGGGGTTTAGTTA	0.433													9	11					0	0	0.006214	0	0
ZNF99	7652	broad.mit.edu	37	19	22952081	22952081	+	Missense_Mutation	SNP	C	T	T	rs149345966	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:22952081C>T	uc010xrh.1	-	2	112	c.112G>A	c.(112-114)GAG>AAG	p.E38K		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CATTGCCACTCCTCCAGAGCG	0.403													16	22					0	0	0.004007	0	0
ZNF91	7644	broad.mit.edu	37	19	23542432	23542432	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:23542432C>T	uc002nre.2	-	4	3462	c.3349G>A	c.(3349-3351)GAG>AAG	p.E1117K	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.E1085K	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	1117	C2H2-type 35.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GCTGAGGACTCTTTAAAGGCT	0.408													15	19					0	0	0.003163	0	0
ZNF91	7644	broad.mit.edu	37	19	23543137	23543137	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:23543137A>C	uc002nre.2	-	4	2757	c.2644T>G	c.(2644-2646)TCC>GCC	p.S882A	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.S850A	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	882						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TCACTCTTGGAAGGTTTCTCT	0.358													11	16					0	0	0.000978	0	0
ZNF681	148213	broad.mit.edu	37	19	23926506	23926506	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:23926506T>A	uc002nrk.3	-	4	1988	c.1846A>T	c.(1846-1848)AAA>TAA	p.K616*	ZNF681_uc002nrl.3_Nonsense_Mutation_p.K547*|ZNF681_uc002nrj.3_Nonsense_Mutation_p.K547*	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTGTAGAGTTTCTCACCAGTA	0.328													5	4					0	0	0.000602	0	0
LOC100101266	100101266	broad.mit.edu	37	19	24345564	24345564	+	RNA	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:24345564T>C	uc010edb.1	-	1		c.686A>G				NR_003603				Homo sapiens hepatitis A virus cellular receptor 1 pseudogene (LOC100101266), non-coding RNA.												0						GGTTGTGTCCTTATTTCTCCC	0.483													63	97					0	0	0.003610	0	0
SLC7A9	11136	broad.mit.edu	37	19	33350862	33350862	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:33350862G>A	uc002ntv.3	-	8	875	c.758C>T	c.(757-759)CCT>CTT	p.P253L	SLC7A9_uc002ntt.3_RNA|SLC7A9_uc002ntu.3_Missense_Mutation_p.P253L|SLC7A9_uc002ntw.3_Missense_Mutation_p.P44L	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	253	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	AATGGCCAAAGGCAGGTTTCT	0.602													9	26					0	0	0.001368	0	0
SLC7A9	11136	broad.mit.edu	37	19	33359359	33359359	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:33359359T>G	uc002ntv.3	-	2	199	c.82A>C	c.(82-84)AAG>CAG	p.K28Q	SLC7A9_uc002ntt.3_RNA|SLC7A9_uc002ntu.3_Missense_Mutation_p.K28Q|SLC7A9_uc002ntw.3_5'UTR	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	28	Cytoplasmic (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	CTTACCTCCTTTTGGAGACTG	0.592													6	44					0	0	0.003080	0	0
GPATCH1	55094	broad.mit.edu	37	19	33600768	33600768	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:33600768C>T	uc002nug.1	+	11	1745	c.1431C>T	c.(1429-1431)TCC>TCT	p.S477S		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	477						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					CCCAGCTCTCCCCTGCAGCGG	0.567													17	189					0	0	0.004007	0	0
GPATCH1	55094	broad.mit.edu	37	19	33608800	33608800	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:33608800G>A	uc002nug.1	+	16	2580	c.2266G>A	c.(2266-2268)GCC>ACC	p.A756T	GPATCH1_uc002nuh.1_Missense_Mutation_p.A133T	NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	756						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					CTTATTCAGGGCCATCTTTGC	0.517													31	287					0	0	0.002445	0	0
GPI	2821	broad.mit.edu	37	19	34868484	34868484	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:34868484C>T	uc002nvg.1	+	5	582	c.479C>T	c.(478-480)TCC>TTC	p.S160F	GPI_uc002nvf.2_Missense_Mutation_p.S199F|GPI_uc010xrv.1_Intron|GPI_uc010xrw.1_Intron|GPI_uc010edl.1_Missense_Mutation_p.S160F	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	160					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					ATTGGCGGCTCCGACCTGGTG	0.592													31	95					0	0	0.002836	0	0
MLL4	9757	broad.mit.edu	37	19	36214692	36214692	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:36214692C>T	uc010eei.2	+	9	3118	c.3118C>T	c.(3118-3120)CCT>TCT	p.P1040S		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1040					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGAGGCCTCCCCTGGTCCTCC	0.687													3	10					0	0	0.004672	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36279003	36279003	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:36279003C>T	uc002obs.1	+	21	3138	c.3053C>T	c.(3052-3054)CCC>CTC	p.P1018L	ARHGAP33_uc002obt.1_Missense_Mutation_p.P1015L|ARHGAP33_uc010eel.2_Intron|ARHGAP33_uc002obv.1_Missense_Mutation_p.P767L	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	1179					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						CCCAGGGGTCCCTCACCTGCC	0.682													14	33					0	0	0.004007	0	0
TYROBP	7305	broad.mit.edu	37	19	36398155	36398155	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:36398155T>C	uc002ocm.2	-	4	297	c.241A>G	c.(241-243)AAA>GAA	p.K81E	TYROBP_uc002ocn.2_Missense_Mutation_p.K80E	NM_003332	NP_003323	O43914	TYOBP_HUMAN	TYRO protein tyrosine kinase binding protein	81	Cytoplasmic (Potential).				axon guidance|cell junction assembly|cellular defense response|intracellular signal transduction|regulation of immune response	integral to plasma membrane|intracellular	identical protein binding|receptor signaling protein activity				0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATACGCTGTTTCCGGGTCGCT	0.542													5	16					0	0	0.001168	0	0
ZNF382	84911	broad.mit.edu	37	19	37101557	37101557	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:37101557C>T	uc002oek.2	+	4	258	c.145C>T	c.(145-147)CAC>TAC	p.H49Y	ZNF382_uc010efa.2_5'UTR|ZNF382_uc010efb.2_Missense_Mutation_p.H48Y|ZNF382_uc002oel.2_Missense_Mutation_p.H49Y	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	49	Mediates interaction with TRIM28 (By similarity).|KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ATCAGGGTTTCACATGGCTAA	0.378													17	61					0	0	0.001523	0	0
ZNF790	388536	broad.mit.edu	37	19	37310048	37310048	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:37310048C>A	uc002oew.2	-	5	1317	c.1198G>T	c.(1198-1200)GGG>TGG	p.G400W	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	400	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TAGGCTTTCCCACATTTCTCA	0.403													29	67					9.39395e-14	1.43235e-13	0.006320	1	0
ZNF568	374900	broad.mit.edu	37	19	37441101	37441101	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:37441101T>C	uc002ofc.2	+	7	1561	c.1046T>C	c.(1045-1047)CTT>CCT	p.L349P	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.L273P|ZNF568_uc010efe.2_Missense_Mutation_p.L273P|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	349	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAGCAAAATCTTATTGAGCAC	0.388													29	59					0	0	0.008361	0	0
ZNF793	390927	broad.mit.edu	37	19	38024235	38024235	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38024235G>A	uc010efm.2	+	7	610	c.168G>A	c.(166-168)GTG>GTA	p.V56V	ZNF793_uc010xts.1_Silent_p.V56V|ZNF793_uc010efo.2_Silent_p.V56V	NM_001013659	NP_001013681	Q6ZN11	ZN793_HUMAN	zinc finger protein 793	56	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AACCAGATGTGATCCTCAGAC	0.532													37	81					0	0	0.004878	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38572510	38572510	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38572510C>T	uc002ohk.2	+	3	814	c.305C>T	c.(304-306)TCC>TTC	p.S102F		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	102					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCAAGCCCCTCCCAGGACACA	0.662													32	79					0	0	0.005524	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38609982	38609982	+	Silent	SNP	C	T	T	rs61729141	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38609982C>T	uc002ohk.2	+	9	2837	c.2328C>T	c.(2326-2328)TTC>TTT	p.F776F		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	776	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CTCCTCCTTTCGGCCCCCCCA	0.522													57	195					0	0	0.003610	0	0
FAM98C	147965	broad.mit.edu	37	19	38899412	38899412	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38899412G>A	uc002oin.1	+	8	959	c.940G>A	c.(940-942)GAC>AAC	p.D314N	FAM98C_uc002oio.1_Missense_Mutation_p.D232N|FAM98C_uc010xtz.1_Missense_Mutation_p.R180K	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	314										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CAACGTTCCAGACCGGGGGGG	0.562													28	70					0	0	0.005443	0	0
RYR1	6261	broad.mit.edu	37	19	38931463	38931463	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38931463G>A	uc002oit.2	+	2	254	c.124G>A	c.(124-126)GGC>AGC	p.G42S	RYR1_uc002oiu.2_Missense_Mutation_p.G42S	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	42	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGAGGGCTTCGGCAACCGCCT	0.662													7	13					0	0	0.001984	0	0
RYR1	6261	broad.mit.edu	37	19	38996449	38996449	+	Nonsense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38996449A>T	uc002oit.2	+	54	8534	c.8404A>T	c.(8404-8406)AAA>TAA	p.K2802*	RYR1_uc002oiu.2_Nonsense_Mutation_p.K2802*|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2802	5.|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACCCCAGGACAAAGAGATTTA	0.577													8	18					0	0	0.004482	0	0
HNRNPL	3191	broad.mit.edu	37	19	39329542	39329542	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:39329542C>T	uc010xul.1	-	9	1358	c.1347G>A	c.(1345-1347)CTG>CTA	p.L449L	HNRNPL_uc010ege.1_Intron|HNRNPL_uc002ojj.1_Silent_p.L105L|HNRNPL_uc002ojo.1_Silent_p.L27L|HNRNPL_uc002ojk.2_Silent_p.L105L|HNRNPL_uc002ojl.2_Silent_p.L105L|HNRNPL_uc010xum.1_Silent_p.L316L|HNRNPL_uc002ojp.1_Silent_p.L105L	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	449	RRM 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			ACCAGACATTCAGCTTCTGCC	0.597													33	47					0	0	0.004878	0	0
PAK4	10298	broad.mit.edu	37	19	39667319	39667319	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:39667319C>T	uc002okj.1	+	9	1910	c.1449C>T	c.(1447-1449)GCC>GCT	p.A483A	PAK4_uc002okl.1_Silent_p.A483A|PAK4_uc002okn.1_Silent_p.A483A|PAK4_uc002okm.1_Silent_p.A330A|PAK4_uc002oko.1_Silent_p.A330A|PAK4_uc002okp.1_Silent_p.A393A	NM_001014831	NP_001014831	O96013	PAK4_HUMAN	p21-activated kinase 4 isoform 1	483	Protein kinase.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			ACTGGATGGCCCCAGAGCTCA	0.647													34	96					0	0	0.004289	0	0
SUPT5H	6829	broad.mit.edu	37	19	39961136	39961136	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:39961136C>T	uc002olo.3	+	18	1829	c.1650C>T	c.(1648-1650)ATC>ATT	p.I550I	SUPT5H_uc002olp.3_Silent_p.I550I|SUPT5H_uc002olq.3_Silent_p.I546I|SUPT5H_uc002oln.3_Silent_p.I550I|SUPT5H_uc002olr.3_Silent_p.I550I|SUPT5H_uc002ols.1_Silent_p.I173I|SUPT5H_uc010egp.1_5'Flank	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	550					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TGGGTGTCATCGTGCGACTAG	0.592													49	118					0	0	0.003610	0	0
PSMC4	5704	broad.mit.edu	37	19	40480516	40480516	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:40480516C>T	uc002omq.2	+	5	592	c.555C>T	c.(553-555)CTC>CTT	p.L185L	PSMC4_uc002omr.2_Silent_p.L154L	NM_006503	NP_006494	P43686	PRS6B_HUMAN	proteasome 26S ATPase subunit 4 isoform 1	185				L -> V (in Ref. 4; AAC32612).	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			ovary(1)	1	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AGCTCCCGCTCACGCATTTCG	0.632													22	49					0	0	0.005443	0	0
LTBP4	8425	broad.mit.edu	37	19	41129549	41129549	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:41129549G>A	uc002ooh.1	+	29	3798	c.3798G>A	c.(3796-3798)AAG>AAA	p.K1266K	LTBP4_uc002oog.1_Silent_p.K1229K|LTBP4_uc002ooi.1_Silent_p.K1199K|LTBP4_uc002ooj.1_Silent_p.K139K|LTBP4_uc002ook.1_Silent_p.K400K|LTBP4_uc002ool.1_Silent_p.K278K|LTBP4_uc010xvp.1_Silent_p.K26K	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1266	EGF-like 13; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGTGTGCAAGAGTGGCGTGT	0.592													10	11					0	0	0.008291	0	0
CYP2A6	1548	broad.mit.edu	37	19	41350595	41350595	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:41350595T>G	uc002opl.3	-	8	1265	c.1244A>C	c.(1243-1245)CAC>CCC	p.H415P		NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	415					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	ATTCAGGAAGTGCTGGGGATT	0.547													32	42					0	0	0.002096	0	0
CYP2B7P1	1556	broad.mit.edu	37	19	41442004	41442004	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:41442004C>T	uc010ehg.1	+	2	182	c.174C>T	c.(172-174)TTC>TTT	p.F58F	CYP2A7_uc002opo.2_Intron|CYP2B7P1_uc010ehh.1_Silent_p.F58F|CYP2B7P1_uc002opq.2_RNA					SubName: Full=Cytochrome P450 2B7 short isoform; SubName: Full=CYP2B protein;											ovary(1)|skin(1)	2						ATTGGCAGTTCCGAGAGAAAT	0.398													6	13					0	0	0.003080	0	0
BCKDHA	593	broad.mit.edu	37	19	41925149	41925149	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:41925149G>A	uc002oqq.2	+	5	623	c.594G>A	c.(592-594)AAG>AAA	p.K198K	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Silent_p.K232K|BCKDHA_uc002oqp.1_Silent_p.K90K|BCKDHA_uc002oqr.2_Silent_p.K198K|BCKDHA_uc010xvz.1_Silent_p.K176K	NM_000709	NP_000700	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha	198					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding				0						ACGGCTGCAAGGAACGCCACT	0.567													8	9					0	0	0.003080	0	0
POU2F2	5452	broad.mit.edu	37	19	42600377	42600377	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:42600377G>A	uc002osp.2	-	8	587	c.520C>T	c.(520-522)CTG>TTG	p.L174L	POU2F2_uc002osn.2_Intron|POU2F2_uc002oso.2_5'UTR|POU2F2_uc002osq.2_Intron|POU2F2_uc002osr.1_Silent_p.L174L	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	174					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				GGGTCGGGCAGCGTAGGGCGG	0.701													4	6					0	0	0.000602	0	0
PRR19	284338	broad.mit.edu	37	19	42813859	42813859	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:42813859C>T	uc002oti.2	+	2	501	c.123C>T	c.(121-123)GCC>GCT	p.A41A	PRR19_uc002oth.1_Silent_p.A41A|PRR19_uc002otj.2_Silent_p.A41A	NM_199285	NP_954979	A6NJB7	PRR19_HUMAN	proline rich 19	41											0		Prostate(69;0.00682)				GGCCATTAGCCCACCACGATC	0.647													20	29					0	0	0.001523	0	0
CEACAM8	1088	broad.mit.edu	37	19	43093719	43093719	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:43093719C>T	uc002oud.2	-	3	695	c.593G>A	c.(592-594)AGG>AAG	p.R198K	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	198	Ig-like C2-type 1.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				AGTGAGGGTCCTGTTGCCATT	0.522													54	87					0	0	0.003610	0	0
PSG5	5673	broad.mit.edu	37	19	43680138	43680138	+	Missense_Mutation	SNP	T	C	C	rs147160846		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:43680138T>C	uc002ovu.2	-	3	724	c.593A>G	c.(592-594)GAA>GGA	p.E198G	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Intron|PSG5_uc002ovx.2_Missense_Mutation_p.E198G|PSG5_uc002ovv.2_Missense_Mutation_p.E291G|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	198	Ig-like C2-type 1.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				GATCCTGTTTTCAATGGGTCG	0.502													67	116					0	0	0.003610	0	0
IRGC	56269	broad.mit.edu	37	19	44223121	44223121	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:44223121C>T	uc002oxh.2	+	2	558	c.411C>T	c.(409-411)TTC>TTT	p.F137F		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	137						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				ATGACTTCTTCCTGCTGGTCT	0.642													10	6					0	0	0.006214	0	0
ZNF221	7638	broad.mit.edu	37	19	44471126	44471126	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:44471126C>T	uc002oxx.2	+	6	1800	c.1472C>T	c.(1471-1473)TCC>TTC	p.S491F	ZNF221_uc010ejb.1_Missense_Mutation_p.S491F|ZNF221_uc010xws.1_Missense_Mutation_p.S491F	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	491	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				GGCTGGGCCTCCTGTCTTTTG	0.448													21	27					0	0	0.001882	0	0
GPR4	2828	broad.mit.edu	37	19	46094512	46094512	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:46094512G>A	uc002pcm.2	-	2	1558	c.613C>T	c.(613-615)CTG>TTG	p.L205L	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	205	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		ACGGCCCGCAGGATGCCCCGG	0.657													13	30					0	0	0.001855	0	0
FBXO46	23403	broad.mit.edu	37	19	46216473	46216473	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:46216473G>A	uc002pcy.2	-	2	406	c.281C>T	c.(280-282)CCC>CTC	p.P94L	FBXO46_uc002pcz.2_Missense_Mutation_p.P94L	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	94							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		TGTATTCCCGGGCTTGATGAC	0.637													17	41					0	0	0.001882	0	0
FOXA3	3171	broad.mit.edu	37	19	46375569	46375569	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:46375569G>A	uc002pdr.2	+	2	503	c.306G>A	c.(304-306)GGG>GGA	p.G102G		NM_004497	NP_004488	P55318	FOXA3_HUMAN	forkhead box A3	102					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)	1		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		TGGTGCACGGGAAGGAGATGC	0.687													15	22					0	0	0.004007	0	0
PRKD2	25865	broad.mit.edu	37	19	47181848	47181848	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:47181848G>A	uc002pfh.2	-	17	2485	c.2143C>T	c.(2143-2145)CCG>TCG	p.P715S	PRKD2_uc002pfd.2_Missense_Mutation_p.P89S|PRKD2_uc010eks.2_Missense_Mutation_p.P118S|PRKD2_uc010ekt.2_5'UTR|PRKD2_uc002pfe.2_Missense_Mutation_p.P235S|PRKD2_uc002pff.2_Missense_Mutation_p.P235S|PRKD2_uc002pfg.2_Missense_Mutation_p.P558S|PRKD2_uc002pfi.2_Missense_Mutation_p.P715S|PRKD2_uc002pfj.2_Missense_Mutation_p.P715S|PRKD2_uc010xye.1_Missense_Mutation_p.P715S|PRKD2_uc002pfk.2_Missense_Mutation_p.P558S	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	715	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		AGGTAGGCCGGCGTGCCCACC	0.627													23	29					0	0	0.002780	0	0
ZC3H4	23211	broad.mit.edu	37	19	47570692	47570693	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:47570692_47570693GG>AA	uc002pga.3	-	15	2870_2871	c.2832_2833CC>TT	c.(2830-2835)CTCCCC>CTTTCC	p.P945S	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	945							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGGTGCCCGGGGAGTGGGTCCA	0.683													43	66					0	0	0.004672	0	0
GPR77	27202	broad.mit.edu	37	19	47844143	47844143	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:47844143G>A	uc010ela.1	+	2	305	c.87G>A	c.(85-87)CTG>CTA	p.L29L	GPR77_uc002pgk.1_Silent_p.L29L	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	29	Extracellular (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		GCGCCTGCCTGGCCATCGACC	0.662													24	38					0	0	0.002299	0	0
DHX34	9704	broad.mit.edu	37	19	47884494	47884495	+	Missense_Mutation	DNP	CA	AC	AC			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:47884494_47884495CA>AC	uc010xyn.1	+	16	3552_3553	c.3211_3212CA>AC	c.(3211-3213)CAC>ACC	p.H1071T	DHX34_uc010xyo.1_Missense_Mutation_p.H200T	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	1071						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GACCTGCCCCCACTGTGGCCTG	0.668													17	23					0	0	0.004672	0	0
GRWD1	83743	broad.mit.edu	37	19	48953957	48953957	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:48953957C>T	uc002pjd.2	+	5	950	c.717C>T	c.(715-717)ATC>ATT	p.I239I		NM_031485	NP_113673	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	239	WD 1.					nucleolus				ovary(1)	1		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		AAAAGAACATCCACCTCTGGA	0.647													13	16					0	0	0.002450	0	0
LMTK3	114783	broad.mit.edu	37	19	49000689	49000690	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:49000689_49000690CC>TT	uc002pjk.2	-	12	3723_3724	c.3723_3724GG>AA	c.(3721-3726)TTGGAC>TTAAAC	p.D1242N		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGTCCCAAGTCCAAGAATAGTC	0.683													13	36					0	0	0.004672	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49364692	49364693	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:49364692_49364693GG>AA	uc002pkx.2	-	5	882_883	c.331_332CC>TT	c.(331-333)CCG>TTG	p.P111L	PLEKHA4_uc002pkw.1_5'Flank|PLEKHA4_uc010eml.2_Missense_Mutation_p.P111L	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	111	PH.					cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GGGGGCTCCCGGCCCATCTGGT	0.609													34	50					0	0	0.004672	0	0
CPT1C	126129	broad.mit.edu	37	19	50203940	50203940	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:50203940G>A	uc002ppj.2	+	4	487	c.282_splice	c.e4-1	p.W94_splice	CPT1C_uc002ppl.3_Splice_Site_p.W94_splice|CPT1C_uc002ppi.2_Splice_Site_p.W11_splice|CPT1C_uc002ppk.2_Splice_Site_p.W94_splice|CPT1C_uc010eng.2_Splice_Site_p.W94_splice|CPT1C_uc010enh.2_Splice_Site_p.W94_splice|CPT1C_uc010ybc.1_Intron	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2						fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TCTCCCCGCAGGGGTGGACAA	0.662													37	41					0	0	0.006999	0	0
KCNC3	3748	broad.mit.edu	37	19	50827173	50827173	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:50827173G>A	uc002pru.1	-	2	1332	c.1037C>T	c.(1036-1038)CCC>CTC	p.P346L	KCNC3_uc002prt.1_5'UTR	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	346					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GGTCAGGAAGGGCTCCGTCTC	0.587													9	21					0	0	0.006214	0	0
NAPSB	256236	broad.mit.edu	37	19	50837578	50837578	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:50837578C>T	uc002prw.2	-	8	1014	c.238G>A	c.(238-240)GAT>AAT	p.D80N	NR1H2_uc002prv.3_Intron	NR_002798				Homo sapiens napsin B pseudogene, mRNA sequence.											central_nervous_system(1)	1						ATGACGTAATCCTGGGCCGTG	0.537													9	6					0	0	0.008291	0	0
LRRC4B	94030	broad.mit.edu	37	19	51022309	51022309	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:51022309C>T	uc002pss.2	-	3	798	c.661G>A	c.(661-663)GAC>AAC	p.D221N		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	221	Extracellular (Potential).|LRR 6.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		TTGGGGATGTCCTTGAGGTTG	0.662													14	5					0	0	0.002450	0	0
CLEC11A	6320	broad.mit.edu	37	19	51226853	51226853	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:51226853G>A	uc002psy.2	+	1	249	c.71G>A	c.(70-72)GGA>GAA	p.G24E		NM_002975	NP_002966	Q9Y240	CLC11_HUMAN	stem cell growth factor precursor	24					positive regulation of cell proliferation	cytoplasm|extracellular region	growth factor activity|sugar binding			ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GGGGCTCggggagcagagagg	0.403													25	23					0	0	0.002780	0	0
GPR32	2854	broad.mit.edu	37	19	51274811	51274811	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:51274811C>T	uc010ycf.1	+	1	954	c.954C>T	c.(952-954)TTC>TTT	p.F318F		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	318	Helical; Name=7; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TCTACGTCTTCGTTGGCAGAG	0.542													30	36					0	0	0.002096	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52003419	52003419	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:52003419C>T	uc002pwx.1	-	2	619	c.563G>A	c.(562-564)GGA>GAA	p.G188E	SIGLEC12_uc002pww.1_Missense_Mutation_p.G70E|SIGLEC12_uc010eoy.1_Intron	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	188	Ig-like V-type 2.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GAACCAGGATCCATAAACAGG	0.542													29	59					0	0	0.002445	0	0
SIGLEC6	946	broad.mit.edu	37	19	52031489	52031489	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:52031489G>A	uc002pwy.2	-	6	1193	c.1031C>T	c.(1030-1032)GCT>GTT	p.A344V	SIGLEC6_uc002pwz.2_Missense_Mutation_p.A328V|SIGLEC6_uc002pxa.2_Intron|SIGLEC6_uc010ydb.1_Missense_Mutation_p.A281V|SIGLEC6_uc010ydc.1_Missense_Mutation_p.A344V|SIGLEC6_uc010eoz.1_Intron	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	344	Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GACACCACCAGCCCTGCCTTC	0.507													10	25					0	0	0.001368	0	0
FPR1	2357	broad.mit.edu	37	19	52249517	52249517	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:52249517G>A	uc002pxq.2	-	2	826	c.731C>T	c.(730-732)TCC>TTC	p.S244F		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	244	Helical; Name=6; (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	TGCGACAAAGGAGAGGACCCG	0.507													19	19					0	0	0.008871	0	0
ZNF836	162962	broad.mit.edu	37	19	52658279	52658279	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:52658279C>T	uc010ydi.1	-	5	3031	c.2657G>A	c.(2656-2658)GGA>GAA	p.G886E	ZNF836_uc010ydj.1_Missense_Mutation_p.G886E	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	886					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGTTTTTCTCCAGAATGAAT	0.393													21	31					0	0	0.002299	0	0
ZNF534	147658	broad.mit.edu	37	19	52941587	52941587	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:52941587C>T	uc002pzk.2	+	4	974	c.913C>T	c.(913-915)CAT>TAT	p.H305Y	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.H292Y	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	305	C2H2-type 4; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGGAAAATTCATACTGGAGA	0.393													11	14					0	0	0.000978	0	0
ZNF468	90333	broad.mit.edu	37	19	53344355	53344355	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:53344355G>A	uc002qaf.2	-	4	1343	c.1192C>T	c.(1192-1194)CTT>TTT	p.L398F	ZNF468_uc002qae.2_Missense_Mutation_p.L345F	NM_001008801	NP_001008801	Q5VIY5	ZN468_HUMAN	zinc finger protein ZNF468 isoform 2	398	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0358)		TGTCTTTCAAGGTGTGATTTG	0.403													22	114					0	0	0.002780	0	0
VN1R2	317701	broad.mit.edu	37	19	53762121	53762121	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:53762121C>T	uc002qbi.2	+	1	577	c.493C>T	c.(493-495)CTT>TTT	p.L165F		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	165	Extracellular (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		ATGCAAATTTCTTTTGTATGC	0.453													23	42					0	0	0.002299	0	0
ZNF813	126017	broad.mit.edu	37	19	53993859	53993859	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:53993859C>T	uc002qbu.2	+	4	501	c.373C>T	c.(373-375)CGA>TGA	p.R125*	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TAGTGCAGACCGATATGATCA	0.408													55	160					0	0	0.003610	0	0
ZNF331	55422	broad.mit.edu	37	19	54080919	54080919	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54080919C>T	uc002qbx.1	+	7	2539	c.1105C>T	c.(1105-1107)CAC>TAC	p.H369Y	ZNF331_uc002qby.1_Missense_Mutation_p.H369Y|ZNF331_uc002qbz.1_Missense_Mutation_p.H369Y|ZNF331_uc002qca.1_Missense_Mutation_p.H369Y|ZNF331_uc010eqr.1_Missense_Mutation_p.H369Y|ZNF331_uc002qcb.1_Missense_Mutation_p.H369Y|ZNF331_uc002qcc.1_Missense_Mutation_p.H369Y|ZNF331_uc002qcd.1_Missense_Mutation_p.H369Y	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	369	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		TTGTGGCTATCACCTCACTCA	0.507			T	?	follicular thyroid adenoma								7	31					0	0	0.003080	0	0
MIR525	574470	broad.mit.edu	37	19	54200848	54200848	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54200848C>T	hsa-mir-525|MI0003152	+			c.62C>T			MIR523_hsa-mir-523|MI0003153_5'Flank|MIR518F_hsa-mir-518f|MI0003154_5'Flank																	0						GAAGGCGCTTCCCTTTAGAGC	0.423													16	54					0	0	0.007413	0	0
NLRP12	91662	broad.mit.edu	37	19	54327292	54327292	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54327292C>T	uc002qch.3	-	1	357	c.137G>A	c.(136-138)GGA>GAA	p.G46E	NLRP12_uc002qci.3_Missense_Mutation_p.G46E|NLRP12_uc002qcj.3_Missense_Mutation_p.G46E|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.G46E	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	46	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CTCCATGCTTCCCCAGGGGAT	0.592													17	79					0	0	0.004990	0	0
MYADM	91663	broad.mit.edu	37	19	54377065	54377065	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54377065C>T	uc002qcl.2	+	3	430	c.282C>T	c.(280-282)TTC>TTT	p.F94F	MYADM_uc002qcm.2_Silent_p.F94F|MYADM_uc002qcn.2_Silent_p.F94F|MYADM_uc002qco.2_Silent_p.F94F|MYADM_uc002qcp.2_Silent_p.F94F	NM_001020820	NP_001018656	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	94	MARVEL 1.			Missing (in Ref. 4; BAC04265).		integral to membrane				ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		AGGCCCGCTTCCCCCTGTCTT	0.617													30	58					0	0	0.008361	0	0
PRKCG	5582	broad.mit.edu	37	19	54386423	54386423	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54386423C>T	uc002qcq.1	+	2	459	c.177C>T	c.(175-177)ATC>ATT	p.I59I	PRKCG_uc010eqz.1_Silent_p.I59I|PRKCG_uc010yef.1_Silent_p.I59I|PRKCG_uc010yeg.1_Silent_p.I59I|PRKCG_uc010yeh.1_5'Flank	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	59	Phorbol-ester/DAG-type 1.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CCAGGGGTATCGGAAAGCAGG	0.647													22	51					0	0	0.006320	0	0
PRKCG	5582	broad.mit.edu	37	19	54396328	54396328	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54396328A>C	uc002qcq.1	+	8	1190	c.908A>C	c.(907-909)GAG>GCG	p.E303A	PRKCG_uc010eqz.1_Missense_Mutation_p.E303A|PRKCG_uc010yef.1_Intron|PRKCG_uc010yeg.1_Missense_Mutation_p.E303A|PRKCG_uc010yeh.1_Missense_Mutation_p.E190A	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	303					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CAGAAGTTTGAGGTACCCAGA	0.597													8	23					0	0	0.003080	0	0
VSTM1	284415	broad.mit.edu	37	19	54545034	54545034	+	Missense_Mutation	SNP	G	A	A	rs148134957	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54545034G>A	uc002qcw.3	-	8	766	c.590C>T	c.(589-591)TCG>TTG	p.S197L	VSTM1_uc010erb.2_RNA|VSTM1_uc002qcx.3_Missense_Mutation_p.S166L	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	197						integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		AGGACTCACCGAGAGAGATAC	0.458													7	26					0	0	0.003080	0	0
LILRB2	10288	broad.mit.edu	37	19	54778659	54778659	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54778659C>T	uc002qfb.2	-	14	1941	c.1675G>A	c.(1675-1677)GAT>AAT	p.D559N	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_3'UTR|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.D558N|LILRB2_uc010yet.1_Missense_Mutation_p.D443N	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	559	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TAGGTCACATCCTGGGGGGCT	0.632													21	52					0	0	0.003330	0	0
LILRB2	10288	broad.mit.edu	37	19	54784319	54784319	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54784319G>A	uc002qfb.2	-	2	299	c.33C>T	c.(31-33)CTC>CTT	p.L11L	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Silent_p.L11L|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Silent_p.L11L|LILRB2_uc010yet.1_5'UTR|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	11					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AAATCTCACCGAGACAGATCA	0.597													33	80					0	0	0.003271	0	0
LILRB1	10859	broad.mit.edu	37	19	55143505	55143506	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55143505_55143506GG>AA	uc002qgj.2	+	6	818_819	c.478_479GG>AA	c.(478-480)GGA>AAA	p.G160K	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.G160K|LILRB1_uc002qgk.2_Missense_Mutation_p.G160K|LILRB1_uc002qgm.2_Missense_Mutation_p.G160K|LILRB1_uc010erq.2_Missense_Mutation_p.G160K|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	160	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GTGTAAGGAAGGAGAAGATGAA	0.609										HNSCC(37;0.09)			27	46					0	0	0.004672	0	0
LILRB1	10859	broad.mit.edu	37	19	55144101	55144102	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55144101_55144102CC>TT	uc002qgj.2	+	7	1188_1189	c.848_849CC>TT	c.(847-849)ACC>ATT	p.T283I	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.T283I|LILRB1_uc002qgk.2_Missense_Mutation_p.T283I|LILRB1_uc002qgm.2_Missense_Mutation_p.T283I|LILRB1_uc010erq.2_Missense_Mutation_p.T283I|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	283	Ig-like C2-type 3.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GCCAACTTCACCCTGGGCCCTG	0.634										HNSCC(37;0.09)			22	57					0	0	0.004672	0	0
LILRB1	10859	broad.mit.edu	37	19	55144129	55144129	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55144129G>A	uc002qgj.2	+	7	1216	c.876G>A	c.(874-876)GGG>GGA	p.G292G	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Silent_p.G292G|LILRB1_uc002qgk.2_Silent_p.G292G|LILRB1_uc002qgm.2_Silent_p.G292G|LILRB1_uc010erq.2_Silent_p.G292G|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	292	Ig-like C2-type 3.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GCTCCTACGGGGGCCAGTACA	0.672										HNSCC(37;0.09)			22	43					0	0	0.005443	0	0
LILRP2	79166	broad.mit.edu	37	19	55221329	55221329	+	RNA	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55221329T>A	uc002qgs.1	+	1		c.1729T>A			LILRP2_uc002qgt.1_Intron	NR_003061				Homo sapiens leukocyte immunoglobulin-like receptor pseudogene 2 (LILRP2), non-coding RNA.												0						CGACTCTTCTTTCCCTCCAGG	0.627													8	12					0	0	0.006214	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55378000	55378000	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55378000G>A	uc002qhl.3	+	9	1245	c.1182G>A	c.(1180-1182)CAG>CAA	p.Q394Q	KIR3DL2_uc010esh.2_Silent_p.Q377Q|KIR3DL2_uc002qho.3_Silent_p.Q394Q			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	394	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		AAGACCCTCAGGAGGTGACGT	0.498													105	214					0	0	0.003610	0	0
NLRP2	55655	broad.mit.edu	37	19	55496493	55496493	+	Silent	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55496493T>C	uc002qij.2	+	7	2195	c.2109T>C	c.(2107-2109)GGT>GGC	p.G703G	NLRP2_uc010yfp.1_Silent_p.G680G|NLRP2_uc010esn.2_Silent_p.G679G|NLRP2_uc010eso.2_Silent_p.G700G|NLRP2_uc010esp.2_Silent_p.G681G	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	703					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ATCTGATGGGTCTAGCAATCA	0.453													20	57					0	0	0.001523	0	0
C19orf51	352909	broad.mit.edu	37	19	55670904	55670904	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55670904G>A	uc002qji.1	-	11	1269	c.1235C>T	c.(1234-1236)GCC>GTC	p.A412V	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Missense_Mutation_p.A227V|C19orf51_uc002qjj.1_Missense_Mutation_p.A459V|C19orf51_uc002qjk.1_Missense_Mutation_p.A358V|C19orf51_uc002qjl.1_Missense_Mutation_p.A479V			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	412											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GACTCACCGGGCTAATTCCAC	0.597													41	115					0	0	0.003610	0	0
C19orf51	352909	broad.mit.edu	37	19	55670969	55670969	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55670969G>A	uc002qji.1	-	11	1204	c.1170C>T	c.(1168-1170)GTC>GTT	p.V390V	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Silent_p.V205V|C19orf51_uc002qjj.1_Silent_p.V437V|C19orf51_uc002qjk.1_Silent_p.V336V|C19orf51_uc002qjl.1_Silent_p.V457V			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	390											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		TGAGAAGATGGACCATACTGC	0.537													25	65					0	0	0.003330	0	0
BRSK1	84446	broad.mit.edu	37	19	55816891	55816891	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55816891C>T	uc002qkg.2	+	16	2104	c.1827C>T	c.(1825-1827)TTC>TTT	p.F609F	BRSK1_uc002qkf.2_Silent_p.F625F|BRSK1_uc002qkh.2_Silent_p.F304F	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	609					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		AACAAATATTCCTCGTGCTAA	0.572													56	128					0	0	0.003610	0	0
NLRP9	338321	broad.mit.edu	37	19	56226485	56226485	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:56226485C>T	uc002qly.2	-	6	2465	c.2437G>A	c.(2437-2439)GAT>AAT	p.D813N		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	813	LRR 3.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ACTCCATTATCTTCCAGGGCA	0.547													30	64					0	0	0.007291	0	0
NLRP11	204801	broad.mit.edu	37	19	56303677	56303677	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:56303677C>T	uc010ygf.1	-	9	3214	c.2503G>A	c.(2503-2505)GAG>AAG	p.E835K	NLRP11_uc002qlz.2_Missense_Mutation_p.E682K|NLRP11_uc002qmb.2_Missense_Mutation_p.E736K|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	835							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TGAAGCTCCTCTAACTGACAG	0.488													30	87					0	0	0.004878	0	0
NLRP11	204801	broad.mit.edu	37	19	56321526	56321526	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:56321526G>A	uc010ygf.1	-	5	1161	c.450C>T	c.(448-450)TTC>TTT	p.F150F	NLRP11_uc002qlz.2_Silent_p.F51F|NLRP11_uc002qmb.2_Silent_p.F51F|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	150	NACHT.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CTCCCATCAGGAACACATTGA	0.393													17	22					0	0	0.006122	0	0
NLRP8	126205	broad.mit.edu	37	19	56467422	56467422	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:56467422C>T	uc002qmh.2	+	3	2069	c.1998C>T	c.(1996-1998)TTC>TTT	p.F666F	NLRP8_uc010etg.2_Silent_p.F666F	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	666						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CCCTGAACTTCATGAACGTGT	0.517													21	64					0	0	0.001523	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701519	56701519	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:56701519G>A	uc010ygh.1	-	4	1165	c.1165C>T	c.(1165-1167)CGG>TGG	p.R389W		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	389	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AAGCGCTTCCGACAGAGATCA	0.522													23	42					0	0	0.001882	0	0
ZFP28	140612	broad.mit.edu	37	19	57051083	57051083	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57051083C>T	uc002qnj.2	+	2	369	c.298C>T	c.(298-300)CAG>TAG	p.Q100*	ZFP28_uc002qni.2_Nonsense_Mutation_p.Q100*	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		AGCCATGTCCCAGGTGAGTTG	0.458													5	23					0	0	0.000602	0	0
ZNF470	388566	broad.mit.edu	37	19	57088341	57088341	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57088341C>T	uc002qnl.3	+	6	1220	c.544C>T	c.(544-546)CAT>TAT	p.H182Y	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		GACAGTTTTTCATCTGAATAC	0.303													16	37					0	0	0.003163	0	0
PEG3	5178	broad.mit.edu	37	19	57325597	57325597	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57325597C>T	uc002qnu.2	-	7	4564	c.4213G>A	c.(4213-4215)GAA>AAA	p.E1405K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E1376K|PEG3_uc002qnv.2_Missense_Mutation_p.E1405K|PEG3_uc002qnw.2_Missense_Mutation_p.E1281K|PEG3_uc002qnx.2_Missense_Mutation_p.E1279K|PEG3_uc010etr.2_Missense_Mutation_p.E1405K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1405	Glu-rich.|3 X 7 AA repeat of P-E-V-E-A-A-E.|2-2.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GCCTCCACTTCTGGCTCGGCA	0.572													25	60					0	0	0.005443	0	0
PEG3	5178	broad.mit.edu	37	19	57334191	57334191	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57334191C>T	uc002qnu.2	-	3	846	c.495G>A	c.(493-495)TGG>TGA	p.W165*	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Nonsense_Mutation_p.W40*|ZIM2_uc002qnq.2_Nonsense_Mutation_p.W40*|ZIM2_uc010etp.2_Nonsense_Mutation_p.W40*|ZIM2_uc010ygs.1_Nonsense_Mutation_p.W40*|PEG3_uc002qnt.2_Nonsense_Mutation_p.W166*|PEG3_uc002qnv.2_Nonsense_Mutation_p.W165*|PEG3_uc002qnw.2_Nonsense_Mutation_p.W40*|PEG3_uc002qnx.2_Nonsense_Mutation_p.W39*|PEG3_uc010etr.2_Nonsense_Mutation_p.W165*	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	165					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCCTCCGGTCCCAGTCCCGGT	0.537													10	9					0	0	0.006214	0	0
PEG3	5178	broad.mit.edu	37	19	57335673	57335673	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57335673G>A	uc002qnu.2	-	1	702	c.351C>T	c.(349-351)CTC>CTT	p.L117L	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_5'UTR|ZIM2_uc002qnq.2_5'UTR|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_5'UTR|PEG3_uc002qnt.2_Silent_p.L117L|PEG3_uc002qnv.2_Silent_p.L117L|PEG3_uc002qnw.2_5'UTR|PEG3_uc002qnx.2_5'UTR|PEG3_uc010etr.2_Silent_p.L117L	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	117	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GCAGAGTGACGAGCTTCTCAC	0.522													36	68					0	0	0.005524	0	0
USP29	57663	broad.mit.edu	37	19	57641248	57641248	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57641248G>A	uc002qny.2	+	4	1561	c.1205G>A	c.(1204-1206)GGG>GAG	p.G402E		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	402					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAAGAATGTGGGGATGAAAAT	0.398													21	49					0	0	0.003954	0	0
ZIM3	114026	broad.mit.edu	37	19	57646553	57646553	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57646553G>A	uc002qnz.1	-	5	1538	c.1152C>T	c.(1150-1152)ATC>ATT	p.I384I		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	384	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCCAGTATGGATTTTTTTAT	0.388													41	96					0	0	0.006999	0	0
ZIM3	114026	broad.mit.edu	37	19	57646987	57646987	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57646987G>A	uc002qnz.1	-	5	1104	c.718C>T	c.(718-720)CAA>TAA	p.Q240*		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	240	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTCTGATGTTGAAAGAGATTT	0.383													39	79					0	0	0.006230	0	0
ZNF543	125919	broad.mit.edu	37	19	57839423	57839423	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57839423C>T	uc002qoi.1	+	4	938	c.593C>T	c.(592-594)TCC>TTC	p.S198F		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GAGAAAAATTCCTATAAATGT	0.403													23	67					0	0	0.002299	0	0
ZNF17	7565	broad.mit.edu	37	19	57932571	57932571	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57932571C>T	uc002qoo.1	+	3	1942	c.1711C>T	c.(1711-1713)CGG>TGG	p.R571W	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Missense_Mutation_p.R573W	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	571	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		CCACCTCATTCGGCACCAAAA	0.403													16	28					0	0	0.006122	0	0
ZNF211	10520	broad.mit.edu	37	19	58152834	58152834	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58152834G>A	uc002qpq.2	+	3	1160	c.980G>A	c.(979-981)AGC>AAC	p.S327N	ZNF211_uc010yhb.1_Missense_Mutation_p.S331N|ZNF211_uc002qpp.2_Missense_Mutation_p.S340N|ZNF211_uc002qpr.2_Missense_Mutation_p.S391N|ZNF211_uc002qps.2_Missense_Mutation_p.S392N|ZNF211_uc002qpt.2_Missense_Mutation_p.S339N|ZNF211_uc010yhc.1_Missense_Mutation_p.S339N|ZNF211_uc010yhd.1_Missense_Mutation_p.S266N|ZNF211_uc010yhe.1_Missense_Mutation_p.S318N	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	327	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAGATATACAGCCTCAATAGC	0.438													8	33					0	0	0.004482	0	0
ZNF154	7710	broad.mit.edu	37	19	58213273	58213274	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58213273_58213274CC>TT	uc010euf.2	-	3	1283_1284	c.1043_1044GG>AA	c.(1042-1044)CGG>CAA	p.R348Q	ZNF776_uc002qpx.2_Intron|ZNF154_uc002qpy.2_RNA	NM_001085384	NP_001078853	Q13106	ZN154_HUMAN	zinc finger protein 154	348	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGTGAACTCCCCGATGTTGAAG	0.495													23	64					0	0	0.004672	0	0
ZNF606	80095	broad.mit.edu	37	19	58489799	58489799	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58489799G>A	uc002qqw.2	-	7	2867	c.2249C>T	c.(2248-2250)TCC>TTC	p.S750F	ZNF606_uc010yhp.1_Missense_Mutation_p.S660F	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	750	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		AATAATAAGGGAAGAATTCTT	0.373													51	85					0	0	0.003610	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58598357	58598357	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58598357C>T	uc002qri.2	-	5	970	c.661G>A	c.(661-663)GAG>AAG	p.E221K	ZSCAN18_uc002qrj.3_Missense_Mutation_p.E221K|ZSCAN18_uc010yhs.1_Missense_Mutation_p.E86K|ZSCAN18_uc002qrh.2_Missense_Mutation_p.E221K|ZSCAN18_uc010yht.1_Missense_Mutation_p.E277K|ZSCAN18_uc002qrk.1_3'UTR|ZSCAN18_uc002qrl.2_3'UTR	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	221					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		TGAGGGTCCTCTGGAAAGGAC	0.637													8	57					0	0	0.004482	0	0
ZNF446	55663	broad.mit.edu	37	19	58988866	58988866	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58988866C>T	uc002qsz.2	+	2	398	c.281C>T	c.(280-282)CCT>CTT	p.P94L	ZNF446_uc002qta.2_Missense_Mutation_p.P94L|ZNF446_uc010eur.2_Missense_Mutation_p.P94L	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	94	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CCAGGCAGTCCTGAGGAGGCC	0.637													6	45					0	0	0.001168	0	0
SLC27A5	10998	broad.mit.edu	37	19	59010861	59010861	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:59010861G>A	uc002qtc.2	-	7	1775	c.1665C>T	c.(1663-1665)TTC>TTT	p.F555F	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	555	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CCTCGGACCGGAAGGTGTCCC	0.657													12	65					0	0	0.001855	0	0
PXDN	7837	broad.mit.edu	37	2	1653160	1653160	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:1653160C>T	uc002qxa.2	-	17	2456	c.2392G>A	c.(2392-2394)GTG>ATG	p.V798M		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	798					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GTGGTGGACACCAGGCGCGGC	0.637													17	52					0	0	0.004990	0	0
FAM49A	81553	broad.mit.edu	37	2	16740731	16740731	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:16740731G>A	uc010exm.1	-	9	982	c.834C>T	c.(832-834)ATC>ATT	p.I278I	FAM49A_uc002rck.1_Silent_p.I278I	NM_030797	NP_110424	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	278						intracellular					0	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			TTCTTACATCGATCTTGGATG	0.483													37	81					0	0	0.005524	0	0
NT5C1B	93034	broad.mit.edu	37	2	18768804	18768804	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:18768804C>T	uc002rcz.2	-	2	189	c.85G>A	c.(85-87)GAA>AAA	p.E29K	NT5C1B_uc002rcy.2_Missense_Mutation_p.E29K|NT5C1B_uc010exr.2_Missense_Mutation_p.E29K|NT5C1B_uc010yju.1_Missense_Mutation_p.E29K|NT5C1B_uc002rda.2_Missense_Mutation_p.E29K|NT5C1B_uc010yjv.1_Missense_Mutation_p.E29K|NT5C1B_uc010yjw.1_Missense_Mutation_p.E29K|NT5C1B_uc010exs.2_Missense_Mutation_p.E29K|NT5C1B_uc002rdb.1_5'Flank	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	29					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TTGTCAGATTCCTTTCTTTTT	0.393													34	80					0	0	0.005524	0	0
OSR1	130497	broad.mit.edu	37	2	19553163	19553163	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:19553163C>T	uc002rdc.2	-	2	707	c.404G>A	c.(403-405)GGT>GAT	p.G135D		NM_145260	NP_660303	Q8TAX0	OSR1_HUMAN	odd-skipped related 1	135					chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)				CTCCCCGCGACCGAGCTTGGC	0.637													25	65					0	0	0.004656	0	0
APOB	338	broad.mit.edu	37	2	21224983	21224983	+	Silent	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:21224983T>G	uc002red.2	-	29	13439	c.13311A>C	c.(13309-13311)TCA>TCC	p.S4437S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4437					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAACTTGACTTGAGAGTTGGG	0.388													218	462					0	0	0.003610	0	0
ATAD2B	54454	broad.mit.edu	37	2	23985211	23985211	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:23985211A>T	uc002rek.3	-	24	3556	c.3262T>A	c.(3262-3264)TCA>ACA	p.S1088T	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Missense_Mutation_p.S328T|ATAD2B_uc002rej.3_Missense_Mutation_p.S256T	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1088							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATGTTACTGATAAGCCTGCA	0.353													12	35					0	0	0.000978	0	0
C2orf39	92749	broad.mit.edu	37	2	26672939	26672939	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:26672939G>A	uc002rhg.2	+	12	1659	c.1585G>A	c.(1585-1587)GAT>AAT	p.D529N		NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	529											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGAGGCTGGATGCCATCTT	0.607													10	4					0	0	0.006214	0	0
CIB4	130106	broad.mit.edu	37	2	26806696	26806696	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:26806696A>C	uc002rhm.2	-	5	428	c.399T>G	c.(397-399)GAT>GAG	p.D133E		NM_001029881	NP_001025052	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	133							calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGACATGTCATCACTGTTCA	0.557													18	66					0	0	0.007413	0	0
C2orf16	84226	broad.mit.edu	37	2	27800886	27800886	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:27800886G>A	uc002rkz.3	+	1	1498	c.1447G>A	c.(1447-1449)GAT>AAT	p.D483N		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	483										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					AGAGCCACTAGATCAAGTCAC	0.423													18	46					0	0	0.004990	0	0
ALK	238	broad.mit.edu	37	2	29917849	29917849	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:29917849C>T	uc002rmy.2	-	3	1726	c.819G>A	c.(817-819)GAG>GAA	p.E273E		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	273	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AATACTCCAGCTCACAGGGGA	0.567			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				24	75					0	0	0.003954	0	0
CAPN13	92291	broad.mit.edu	37	2	30987150	30987150	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:30987150G>A	uc002rnn.2	-	6	723	c.547C>T	c.(547-549)CTG>TTG	p.L183L	CAPN13_uc002rnp.1_Silent_p.L183L	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	183	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					CCATAGTGCAGATCGGAATAG	0.582													7	24					0	0	0.003080	0	0
THUMPD2	80745	broad.mit.edu	37	2	39993221	39993221	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:39993221G>A	uc002rru.2	-	5	816	c.779C>T	c.(778-780)TCT>TTT	p.S260F	THUMPD2_uc002rrv.2_RNA|THUMPD2_uc010ynt.1_Missense_Mutation_p.S151F|THUMPD2_uc010ynu.1_3'UTR	NM_025264	NP_079540	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	260	THUMP.						methyltransferase activity			skin(1)	1		all_hematologic(82;0.248)				CCCCACCACAGAGTAAATGTC	0.328													27	86					0	0	0.002096	0	0
EML4	27436	broad.mit.edu	37	2	42531667	42531667	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:42531667T>G	uc002rsi.2	+	17	2205	c.1943T>G	c.(1942-1944)GTG>GGG	p.V648G	EML4_uc010fap.2_Missense_Mutation_p.V590G|EML4_uc002rsj.2_Missense_Mutation_p.V337G|EML4_uc010faq.2_Intron|EML4_uc010ynv.1_5'UTR	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	648					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						GGCACAGTGGTGGCCATAGGA	0.468			T	ALK	NSCLC								54	46					0	0	0.003610	0	0
THADA	63892	broad.mit.edu	37	2	43520266	43520266	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:43520266C>T	uc002rsw.3	-	32	4877	c.4525G>A	c.(4525-4527)GTG>ATG	p.V1509M	THADA_uc010far.2_Missense_Mutation_p.V704M|THADA_uc002rsx.3_Missense_Mutation_p.V1509M|THADA_uc002rsy.3_RNA	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1509							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AGGCCTGGCACCTTGAAGGCC	0.567													137	359					0	0	0.003610	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43919740	43919740	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:43919740G>A	uc010yny.1	+	4	357	c.274G>A	c.(274-276)GAG>AAG	p.E92K	PLEKHH2_uc002rte.3_Missense_Mutation_p.E92K|PLEKHH2_uc002rtf.3_Missense_Mutation_p.E92K	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	92	Potential.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCAAGATCTGGAGTCGCTAAT	0.338													94	244					0	0	0.003610	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43927012	43927012	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:43927012C>T	uc010yny.1	+	8	998	c.915C>T	c.(913-915)ACC>ACT	p.T305T	PLEKHH2_uc002rte.3_Silent_p.T305T|PLEKHH2_uc002rtf.3_Silent_p.T304T	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	305						cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCACATCCACCCTCTCCAGTC	0.512													106	248					0	0	0.003610	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43937379	43937379	+	Silent	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:43937379T>G	uc010yny.1	+	13	2207	c.2124T>G	c.(2122-2124)GGT>GGG	p.G708G	PLEKHH2_uc002rte.3_Silent_p.G708G|PLEKHH2_uc002rtf.3_Silent_p.G707G	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	708	PH 1.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAAAATCTGGTTATTTATTAA	0.353													130	249					0	0	0.003610	0	0
LHCGR	3973	broad.mit.edu	37	2	48915873	48915873	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:48915873C>T	uc002rwu.3	-	11	1133	c.1063G>A	c.(1063-1065)GAT>AAT	p.D355N	GTF2A1L_uc002rwt.2_Intron	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	355	Extracellular (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	CCCATAATATCTTCACAGGGA	0.443									Familial_Male-Limited_Precocious_Puberty				36	85					0	0	0.004878	0	0
NRXN1	9378	broad.mit.edu	37	2	50464101	50464101	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:50464101C>T	uc010fbp.2	-	2	1074	c.267G>A	c.(265-267)ACG>ACA	p.T89T	NRXN1_uc002rxb.3_Silent_p.T796T|NRXN1_uc010fbq.2_Silent_p.T1164T|NRXN1_uc002rxe.3_Silent_p.T1124T|NRXN1_uc002rxc.1_RNA	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	89	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AGATATATGTCGTCCCAGCTG	0.408													19	47					0	0	0.002299	0	0
SPTBN1	6711	broad.mit.edu	37	2	54858354	54858354	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:54858354C>T	uc002rxu.2	+	16	3419	c.3170C>T	c.(3169-3171)TCC>TTC	p.S1057F	SPTBN1_uc002rxx.2_Missense_Mutation_p.S1044F	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1057	Spectrin 8.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CGAGAGGCCTCCCTGGGAGAG	0.632													20	48					0	0	0.001523	0	0
SPTBN1	6711	broad.mit.edu	37	2	54872557	54872557	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:54872557C>T	uc002rxu.2	+	21	4710	c.4461C>T	c.(4459-4461)ATC>ATT	p.I1487I	SPTBN1_uc002rxx.2_Silent_p.I1474I	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1487	Spectrin 12.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CCAAAGAGATCCATCAGTTCA	0.552													16	44					0	0	0.003163	0	0
RTN4	57142	broad.mit.edu	37	2	55200750	55200750	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:55200750A>T	uc002rye.2	-	8	3783	c.3485T>A	c.(3484-3486)ATA>AAA	p.I1162K	RTN4_uc002ryc.2_Missense_Mutation_p.I169K|RTN4_uc002ryd.2_Missense_Mutation_p.I956K|RTN4_uc002ryf.2_Missense_Mutation_p.I362K|RTN4_uc002ryg.2_Missense_Mutation_p.I343K	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	1162	Cytoplasmic (Potential).|Reticulon.				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						ATAATGATCTATCTGTGCCTG	0.343													35	27					0	0	0.007835	0	0
FAM161A	84140	broad.mit.edu	37	2	62067438	62067438	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:62067438G>A	uc010ypo.1	-	3	803	c.701C>T	c.(700-702)CCC>CTC	p.P234L	FAM161A_uc002sbm.3_Missense_Mutation_p.P234L|FAM161A_uc002sbn.3_Missense_Mutation_p.P44L|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Missense_Mutation_p.P125L	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	234					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						TGTAATTGTGGGCACCCATTC	0.363													25	78					0	0	0.004656	0	0
GKN2	200504	broad.mit.edu	37	2	69174314	69174314	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:69174314G>A	uc002sfa.2	-	4	389	c.280C>T	c.(280-282)CTG>TTG	p.L94L	GKN2_uc002sfb.3_Silent_p.L94L	NM_182536	NP_872342	Q86XP6	GKN2_HUMAN	trefoil factor interactions(z) 1 precursor	94	BRICHOS.					extracellular region					0						AGATTGTTCAGAGGAGGGATG	0.463													28	108					0	0	0.008361	0	0
ANTXR1	84168	broad.mit.edu	37	2	69397402	69397403	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:69397402_69397403CC>TT	uc002sfg.2	+	14	1426_1427	c.1070_1071CC>TT	c.(1069-1071)CCC>CTT	p.P357L	ANTXR1_uc002sff.2_Missense_Mutation_p.P357L	NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	357	Cytoplasmic (Potential).				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						GTCCCTCCACCCCCTGCCGAGG	0.559									Familial_Infantile_Hemangioma				11	32					0	0	0.004672	0	0
ANTXR1	84168	broad.mit.edu	37	2	69420468	69420468	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:69420468G>A	uc002sfg.2	+	17	1711	c.1355G>A	c.(1354-1356)GGA>GAA	p.G452E		NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	452	Cytoplasmic (Potential).				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						TTATTTCAGGGAAAACTCGAT	0.468									Familial_Infantile_Hemangioma				26	79					0	0	0.005443	0	0
EXOC6B	23233	broad.mit.edu	37	2	72786608	72786608	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:72786608G>A	uc010fep.2	-	8	1027	c.889C>T	c.(889-891)CGA>TGA	p.R297*	EXOC6B_uc002sij.2_Nonsense_Mutation_p.R297*	NM_015189	NP_056004	Q9Y2D4	EXC6B_HUMAN	SEC15-like 2	297					protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2						TGTAGACATCGATAAACTGGA	0.368													7	29					0	0	0.001984	0	0
TET3	200424	broad.mit.edu	37	2	74317148	74317148	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:74317148C>T	uc002skb.3	+	5	2608	c.2608C>T	c.(2608-2610)CGC>TGC	p.R870C		NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	870							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TCGCAAGTTCCGCCTCGCAGG	0.597													34	102					0	0	0.003271	0	0
C2orf65	130951	broad.mit.edu	37	2	74787386	74787386	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:74787386G>A	uc002smy.2	-	9	1431	c.1314C>T	c.(1312-1314)ACC>ACT	p.T438T	C2orf65_uc010ysa.1_Silent_p.T438T|C2orf65_uc010ffp.2_Silent_p.T87T|C2orf65_uc002smx.2_Silent_p.T194T	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	438					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						AGGGGTTGTAGGTGGGCTCCA	0.572													50	27					0	0	0.003610	0	0
REG1P	5969	broad.mit.edu	37	2	79363152	79363152	+	RNA	SNP	C	T	T	rs75820374	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:79363152C>T	uc002soa.1	-	4		c.1162G>A			REG1P_uc002sob.1_RNA|REG1P_uc002soc.1_RNA					Homo sapiens mRNA for Reg-related sequence derived peptide-1, complete cds.												0						ATCCAATGTCCCAGGATTTGT	0.522													4	12					0	0	0.000602	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529698	80529698	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:80529698C>T	uc002sok.1	-	2	1517	c.1247G>A	c.(1246-1248)GGC>GAC	p.G416D	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	416	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GGCGTGCTCGCCGCCTGGAAG	0.682										HNSCC(69;0.2)			10	33					0	0	0.000978	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530636	80530636	+	Silent	SNP	G	A	A	rs138746641		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:80530636G>A	uc002sok.1	-	2	579	c.309C>T	c.(307-309)TCC>TCT	p.S103S	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	103	LRR 1.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CCCCCTGCACGGAGCAGATGT	0.592										HNSCC(69;0.2)			37	82					0	0	0.006230	0	0
RNF181	51255	broad.mit.edu	37	2	85824049	85824049	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:85824049A>C	uc002spv.1	+	3	372	c.322A>C	c.(322-324)AGC>CGC	p.S108R		NM_016494	NP_057578	Q9P0P0	RN181_HUMAN	ring finger protein 181	108	RING-type; atypical.						ligase activity|zinc ion binding				0						GCCCTGGCTAAGCAAGGTACT	0.527													31	66					0	0	0.008361	0	0
CD8B	926	broad.mit.edu	37	2	87042831	87042831	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:87042831C>T	uc002srw.2	-	6	681	c.631G>A	c.(631-633)GAA>AAA	p.E211K	RMND5A_uc002srs.3_Intron|CD8B_uc002srx.2_3'UTR|CD8B_uc002sry.2_Missense_Mutation_p.E181K|CD8B_uc010fgt.2_Silent_p.G168G	NM_172213	NP_757362	P10966	CD8B_HUMAN	CD8b antigen isoform 2 precursor	Error:Variant_position_missing_in_P10966_after_alignment					immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			upper_aerodigestive_tract(1)|skin(1)	2						GATATACCTTCCCCTTGAGGC	0.408													71	144					0	0	0.003610	0	0
Unknown	0	broad.mit.edu	37	2	89160296	89160296	+	RNA	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:89160296G>A	uc010ytr.1	-	239		c.9494C>T			uc002sti.1_5'Flank|uc002stj.1_Intron					Parts of antibodies, mostly variable regions.																		CTTTTTGAAAGAATCTGGTAC	0.358													7	15					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	2	89247291	89247291	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:89247291C>T	uc010ytr.1	-	100		c.7893G>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		ACCCTCATGTCCATGCTGTGT	0.547													44	104					0	0	0.003610	0	0
SNRNP200	23020	broad.mit.edu	37	2	96953256	96953256	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:96953256G>A	uc002svu.2	-	26	3491	c.3405C>T	c.(3403-3405)CTC>CTT	p.L1135L	SNRNP200_uc002svt.2_5'Flank|SNRNP200_uc010yuj.1_5'Flank|SNRNP200_uc002svv.1_5'Flank|SNRNP200_uc002svw.1_Silent_p.L207L	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1135	SEC63 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						CTTCCTCAGGGAGTTTCCGGA	0.517													30	49					0	0	0.007291	0	0
LMAN2L	81562	broad.mit.edu	37	2	97400219	97400219	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:97400219G>A	uc002swu.2	-	3	387	c.351C>T	c.(349-351)ATC>ATT	p.I117I	LMAN2L_uc002swv.2_Silent_p.I117I|LMAN2L_uc010yut.1_5'UTR|LMAN2L_uc010yuu.1_5'UTR|LMAN2L_uc010yuv.1_5'UTR|LMAN2L_uc010yuw.1_5'UTR|LMAN2L_uc002sww.2_5'UTR|LMAN2L_uc010yux.1_5'UTR	NM_030805	NP_110432	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like isoform 2	117	L-type lectin-like.|Lumenal (Potential).				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding				0						CTTGTCCATGGATTTTGAAGT	0.463													42	55					0	0	0.008740	0	0
CNGA3	1261	broad.mit.edu	37	2	99013380	99013380	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:99013380G>A	uc002syt.2	+	8	2164	c.1747G>A	c.(1747-1749)GAT>AAT	p.D583N	CNGA3_uc002syu.2_Missense_Mutation_p.D565N|CNGA3_uc010fij.2_Missense_Mutation_p.D587N	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	583	cGMP.				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CTCAAAGGACGATCTCATGGA	0.562													16	31					0	0	0.003163	0	0
CNGA3	1261	broad.mit.edu	37	2	99013680	99013680	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:99013680C>T	uc002syt.2	+	8	2464	c.2047C>T	c.(2047-2049)CCC>TCC	p.P683S	CNGA3_uc002syu.2_Missense_Mutation_p.P665S|CNGA3_uc010fij.2_Missense_Mutation_p.P687S	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	683					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						TGGGGAAGTTCCCGGGGATGC	0.552													10	24					0	0	0.001368	0	0
AFF3	3899	broad.mit.edu	37	2	100167981	100167982	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:100167981_100167982GG>AA	uc002tag.2	-	24	3871_3872	c.3635_3636CC>TT	c.(3634-3636)TCC>TTT	p.S1212F	AFF3_uc002taf.2_Missense_Mutation_p.S1237F	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	1212					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GGCCCTGTTGGGAGTACTGGAC	0.589													10	17					0	0	0.004672	0	0
TBC1D8	11138	broad.mit.edu	37	2	101670590	101670590	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:101670590G>A	uc010fiv.2	-	4	697	c.566C>T	c.(565-567)TCC>TTC	p.S189F	TBC1D8_uc010yvw.1_Missense_Mutation_p.S204F|TBC1D8_uc002tau.3_5'UTR	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	189	GRAM 1.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CAGGAAGAAGGAGTAGAAGCA	0.597													6	6					0	0	0.001168	0	0
MAP4K4	9448	broad.mit.edu	37	2	102477313	102477313	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:102477313C>T	uc002tbg.2	+	16	1786	c.1731C>T	c.(1729-1731)AAC>AAT	p.N577N	MAP4K4_uc002tbc.2_Silent_p.N577N|MAP4K4_uc002tbd.2_Silent_p.N546N|MAP4K4_uc002tbe.2_Intron|MAP4K4_uc002tbf.2_Silent_p.N546N|MAP4K4_uc010yvy.1_Intron|MAP4K4_uc002tbh.2_Intron|MAP4K4_uc002tbi.2_Intron|MAP4K4_uc010yvz.1_Intron|MAP4K4_uc002tbk.2_Intron|MAP4K4_uc002tbj.1_3'UTR	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	577					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GGAAAACTAACCACAGCTCCC	0.448													7	3					0	0	0.008291	0	0
IL1R1	3554	broad.mit.edu	37	2	102793021	102793021	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:102793021A>T	uc002tbq.2	+	12	1830	c.1512A>T	c.(1510-1512)AAA>AAT	p.K504N	IL1R1_uc010fix.2_Missense_Mutation_p.K473N|IL1R1_uc002tbr.2_Missense_Mutation_p.K504N	NM_000877	NP_000868	P14778	IL1R1_HUMAN	interleukin 1 receptor, type I precursor	504	TIR.|Cytoplasmic (Potential).				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			skin(1)	1					Anakinra(DB00026)	AATCGATTAAATTCATTAAGC	0.428													11	11					0	0	0.001368	0	0
SLC9A2	6549	broad.mit.edu	37	2	103311508	103311508	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:103311508G>A	uc002tca.2	+	7	1664	c.1522G>A	c.(1522-1524)GAT>AAT	p.D508N		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	508	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						TTAGTTGTTTGATCATGTGAA	0.363													32	46					0	0	0.001786	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105883951	105883951	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:105883951G>A	uc002tcq.2	-	12	2556	c.2472C>T	c.(2470-2472)CCC>CCT	p.P824P	TGFBRAP1_uc010fjc.2_Silent_p.P593P|TGFBRAP1_uc002tcr.3_Silent_p.P824P|uc002tcp.2_5'Flank	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	824					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						GCTCACAAAAGGGATTTTGGC	0.468													34	46					0	0	0.003755	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105924152	105924152	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:105924152G>A	uc002tcq.2	-	2	691	c.607C>T	c.(607-609)CCC>TCC	p.P203S	TGFBRAP1_uc002tcr.3_Missense_Mutation_p.P203S	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	203	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						CTGCAGTAGGGAAACAGGTCC	0.607													48	61					0	0	0.003610	0	0
RGPD4	285190	broad.mit.edu	37	2	108488640	108488640	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:108488640C>T	uc010ywk.1	+	20	4262	c.4180C>T	c.(4180-4182)CGT>TGT	p.R1394C	RGPD4_uc002tdu.2_Missense_Mutation_p.R581C|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1394	RanBD1 2.				intracellular transport		binding			skin(2)	2						TAAGCAAGTTCGTATAGTGAT	0.358													98	149					0	0	0.003610	0	0
RANBP2	5903	broad.mit.edu	37	2	109383770	109383770	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:109383770C>T	uc002tem.3	+	20	6901	c.6775C>T	c.(6775-6777)CGT>TGT	p.R2259C		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2259					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AAATCTTTTCCGTTTTGGTGA	0.403													113	160					0	0	0.003610	0	0
POLR1B	84172	broad.mit.edu	37	2	113315512	113315512	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:113315512C>T	uc002thw.2	+	8	1764	c.1184C>T	c.(1183-1185)TCT>TTT	p.S395F	POLR1B_uc010fkn.2_Missense_Mutation_p.S339F|POLR1B_uc002thx.2_Missense_Mutation_p.S256F|POLR1B_uc010fko.2_Intron|POLR1B_uc010fkp.2_Intron|POLR1B_uc010yxn.1_Missense_Mutation_p.S433F|POLR1B_uc002thy.2_Missense_Mutation_p.S256F|POLR1B_uc010yxo.1_Missense_Mutation_p.S172F	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	395					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						TGGTTAGTGTCTATTAAAATA	0.259													5	6					0	0	0.000602	0	0
IL1F8	27177	broad.mit.edu	37	2	113786623	113786623	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:113786623C>T	uc002tiq.1	-	4	258	c.154G>A	c.(154-156)GAA>AAA	p.E52K	IL1F8_uc002tir.1_Missense_Mutation_p.E52K	NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	52					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						TCACTGAATTCTGTGTCTCTA	0.428													26	32					0	0	0.005443	0	0
MARCO	8685	broad.mit.edu	37	2	119732008	119732008	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:119732008G>A	uc002tln.1	+	5	692	c.560G>A	c.(559-561)GGA>GAA	p.G187E	MARCO_uc010yyf.1_Missense_Mutation_p.G109E	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	187	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGACGAGATGGAGCAACAGGT	0.592													10	10					0	0	0.006214	0	0
GLI2	2736	broad.mit.edu	37	2	121708851	121708851	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:121708851C>T	uc010flp.2	+	3	317	c.287C>T	c.(286-288)TCT>TTT	p.S96F	GLI2_uc010yyu.1_Missense_Mutation_p.S96F|GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Intron|GLI2_uc010flo.1_5'UTR|GLI2_uc002tmw.1_Missense_Mutation_p.S96F	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	96					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CCTGTCATCTCTGACATCTCC	0.642													37	65					0	0	0.008740	0	0
GLI2	2736	broad.mit.edu	37	2	121736031	121736031	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:121736031C>T	uc010flp.2	+	9	1420	c.1390C>T	c.(1390-1392)CAC>TAC	p.H464Y	GLI2_uc002tmq.1_Missense_Mutation_p.H136Y|GLI2_uc002tmr.1_Missense_Mutation_p.H119Y|GLI2_uc002tmt.3_Missense_Mutation_p.H136Y|GLI2_uc002tmu.3_Missense_Mutation_p.H119Y|GLI2_uc002tmw.1_Missense_Mutation_p.H447Y	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	464	C2H2-type 1.				axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CGAGCACATCCACGGGGAGAA	0.627													46	73					0	0	0.003610	0	0
IMP4	92856	broad.mit.edu	37	2	131103620	131103620	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:131103620C>T	uc002tra.1	+	7	641	c.624C>T	c.(622-624)CCC>CCT	p.P208P		NM_033416	NP_219484	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein,	208	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)	2	Colorectal(110;0.1)					ACCTATTTCCCGTGCCCAAAG	0.592													20	31					0	0	0.001882	0	0
GPR148	344561	broad.mit.edu	37	2	131487717	131487718	+	Missense_Mutation	DNP	CC	TT	TT	rs147782890		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:131487717_131487718CC>TT	uc002trv.1	+	1	995_996	c.993_994CC>TT	c.(991-996)GTCCGG>GTTTGG	p.R332W		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	332	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					TGGGCATGGTCCGGGGCCACCT	0.545													7	14					0	0	0.004672	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542791	133542791	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:133542791C>T	uc002ttp.2	-	14	1967	c.1593G>A	c.(1591-1593)AAG>AAA	p.K531K	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	531							protein binding				0						CAGGCCTTTCCTTGGGATAAA	0.517													51	54					0	0	0.003610	0	0
CCNT2	905	broad.mit.edu	37	2	135676478	135676478	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:135676478G>A	uc002tuc.1	+	1	86	c.54G>A	c.(52-54)CTG>CTA	p.L18L	uc010zbe.1_5'Flank|CCNT2_uc002tub.1_Silent_p.L18L|CCNT2_uc010zbf.1_5'UTR|CCNT2_uc002tud.1_5'UTR	NM_058241	NP_490595	O60583	CCNT2_HUMAN	cyclin T2 isoform b	18					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein kinase binding			ovary(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.107)		GGGAACAGCTGGAGAACACGC	0.647													5	15					0	0	0.000602	0	0
LRP1B	53353	broad.mit.edu	37	2	141092073	141092073	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:141092073C>T	uc002tvj.1	-	79	13144	c.12172G>A	c.(12172-12174)GAT>AAT	p.D4058N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4058	Extracellular (Potential).|LDL-receptor class B 35.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGTGTACCATCCATGGCTGCT	0.438										TSP Lung(27;0.18)			16	30					0	0	0.006122	0	0
LRP1B	53353	broad.mit.edu	37	2	141607881	141607881	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:141607881G>A	uc002tvj.1	-	29	5701	c.4729C>T	c.(4729-4731)CTT>TTT	p.L1577F	LRP1B_uc010fnl.1_Missense_Mutation_p.L759F	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1577	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTGCATAAAGAAGAAATTTT	0.303										TSP Lung(27;0.18)			11	10					0	0	0.000978	0	0
MBD5	55777	broad.mit.edu	37	2	149226560	149226560	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:149226560C>T	uc002twm.3	+	9	2036	c.1048C>T	c.(1048-1050)CCA>TCA	p.P350S	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.P350S|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	350	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TCAGAAAAAGCCATTAACATC	0.438													12	22					0	0	0.000978	0	0
RIF1	55183	broad.mit.edu	37	2	152308153	152308153	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:152308153A>G	uc002txm.2	+	21	2408	c.2278A>G	c.(2278-2280)ATT>GTT	p.I760V	RIF1_uc002txl.2_Missense_Mutation_p.I760V|RIF1_uc010fnv.1_Missense_Mutation_p.I724V|RIF1_uc002txn.2_Missense_Mutation_p.I760V|RIF1_uc002txo.2_Missense_Mutation_p.I760V	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	760					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TATTTATATTATTACTGTAAT	0.303													29	19					0	0	0.002096	0	0
NEB	4703	broad.mit.edu	37	2	152497159	152497159	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:152497159G>A	uc010fnx.2	-	61	8586	c.8395C>T	c.(8395-8397)CGT>TGT	p.R2799C	NEB_uc002txu.2_5'Flank	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2799	Nebulin 75.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGCTGCTTACGATAGCCTTCT	0.433													22	43					0	0	0.001882	0	0
NEB	4703	broad.mit.edu	37	2	152579941	152579941	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:152579941G>A	uc010fnx.2	-	9	863	c.672C>T	c.(670-672)AGC>AGT	p.S224S		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	224	Nebulin 5.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCAGTTCCGGGCTATCATTAT	0.448													4	10					0	0	0.000248	0	0
GPD2	2820	broad.mit.edu	37	2	157425455	157425455	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:157425455C>T	uc002tzf.3	+	10	1644	c.1284C>T	c.(1282-1284)GGC>GGT	p.G428G	GPD2_uc010zch.1_Silent_p.G201G|GPD2_uc002tzd.3_Silent_p.G428G|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	428					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						GTGAGAGTGGCCTTATTACTA	0.308													43	61					0	0	0.003610	0	0
LY75	4065	broad.mit.edu	37	2	160664965	160664965	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:160664965G>A	uc002ubc.3	-	33	4886	c.4817C>T	c.(4816-4818)TCT>TTT	p.S1606F	LY75_uc002ubb.3_Missense_Mutation_p.S1606F|LY75_uc010fos.2_Missense_Mutation_p.S1606F	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1606	Extracellular (Potential).|C-type lectin 10.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		CTTACCAACAGAATGTTGAGA	0.343													26	28					0	0	0.006320	0	0
LY75	4065	broad.mit.edu	37	2	160667116	160667116	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:160667116G>A	uc002ubc.3	-	32	4689	c.4620C>T	c.(4618-4620)ATC>ATT	p.I1540I	LY75_uc002ubb.3_Silent_p.I1540I|LY75_uc010fos.2_Silent_p.I1540I	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1540	Extracellular (Potential).				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		CCTTGTACTGGATCCACCGTG	0.373													79	101					0	0	0.003610	0	0
LY75	4065	broad.mit.edu	37	2	160692099	160692099	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:160692099C>T	uc002ubc.3	-	26	3634	c.3565G>A	c.(3565-3567)GAA>AAA	p.E1189K	LY75_uc002ubb.3_Missense_Mutation_p.E1189K|LY75_uc010fos.2_Missense_Mutation_p.E1189K	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1189	Extracellular (Potential).|C-type lectin 7.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		CCATTAGTTTCAGCCCAGCGA	0.413													20	38					0	0	0.001523	0	0
PLA2R1	22925	broad.mit.edu	37	2	160833917	160833917	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:160833917G>A	uc002ube.1	-	15	2486	c.2279C>T	c.(2278-2280)TCG>TTG	p.S760L	PLA2R1_uc010zcp.1_Missense_Mutation_p.S760L|PLA2R1_uc002ubf.2_Missense_Mutation_p.S760L	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	760	Extracellular (Potential).|C-type lectin 4.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GTCTAAAAACGAAGAGACAAC	0.388													14	23					0	0	0.001855	0	0
IFIH1	64135	broad.mit.edu	37	2	163134116	163134116	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:163134116C>T	uc002uce.2	-	10	2075	c.1853G>A	c.(1852-1854)CGA>CAA	p.R618Q		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	618					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						ATCTATCATTCGAATTGTGTC	0.299													49	33					0	0	0.003610	0	0
SCN1A	6323	broad.mit.edu	37	2	166848354	166848354	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:166848354C>T	uc010zcz.1	-	26	5416	c.5398G>A	c.(5398-5400)GTT>ATT	p.V1800I		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1811	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTCTCCCAAACCTCATAGAAC	0.463													35	54					0	0	0.004289	0	0
SCN1A	6323	broad.mit.edu	37	2	166893031	166893031	+	Missense_Mutation	SNP	G	A	A	rs121918625		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:166893031G>A	uc010zcz.1	-	16	2941	c.2923C>T	c.(2923-2925)CTC>TTC	p.L975F	SCN1A_uc002udo.3_Missense_Mutation_p.L855F|SCN1A_uc010fpk.2_Missense_Mutation_p.L827F	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	986	Helical; Name=S6 of repeat II; (By similarity).|II.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GCCAGAAAGAGATTCAGGACC	0.353													14	13					0	0	0.001855	0	0
SCN9A	6335	broad.mit.edu	37	2	167142945	167142945	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:167142945C>T	uc010fpl.2	-	11	1844	c.1503G>A	c.(1501-1503)TCG>TCA	p.S501S	uc002udp.2_Intron|SCN9A_uc002udr.1_Silent_p.S372S|SCN9A_uc002uds.1_Silent_p.S372S|SCN9A_uc002udt.1_Silent_p.S372S	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	501				S -> P (in Ref. 3; AAT85835).		voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	ATTCTGATTTCGACAATTTCT	0.428													47	46					0	0	0.003610	0	0
SCN9A	6335	broad.mit.edu	37	2	167162316	167162316	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:167162316G>A	uc010fpl.2	-	5	923	c.582C>T	c.(580-582)GTC>GTT	p.V194V	SCN9A_uc002udr.1_Silent_p.V65V|SCN9A_uc002uds.1_Silent_p.V65V|SCN9A_uc002udt.1_Silent_p.V65V	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	194	Helical; Name=S3 of repeat I; (Potential).|I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	AAACAATGACGACAAAATCCA	0.398													23	32					0	0	0.003330	0	0
XIRP2	129446	broad.mit.edu	37	2	168100111	168100111	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:168100111G>A	uc002udx.2	+	8	2227	c.2209G>A	c.(2209-2211)GAA>AAA	p.E737K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E562K|XIRP2_uc010fpq.2_Missense_Mutation_p.E515K|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	562	Xin 6.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAAATGTTTCGAAACTCAACC	0.373													13	19					0	0	0.002450	0	0
XIRP2	129446	broad.mit.edu	37	2	168105581	168105581	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:168105581A>T	uc002udx.2	+	8	7697	c.7679A>T	c.(7678-7680)AAA>ATA	p.K2560I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.K2385I|XIRP2_uc010fpq.2_Missense_Mutation_p.K2338I|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2385	Potential.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GAAATTGAAAAACAGAAACAG	0.303													45	43					0	0	0.002852	0	0
ABCB11	8647	broad.mit.edu	37	2	169825893	169825893	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:169825893C>T	uc002ueo.1	-	16	2104	c.1978G>A	c.(1978-1980)GGA>AGA	p.G660R	ABCB11_uc010zda.1_Missense_Mutation_p.G102R|ABCB11_uc010zdb.1_Missense_Mutation_p.G136R	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	660	Cytoplasmic (Potential).|Interaction with HAX1 (By similarity).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GCTTGATTTCCCTGGCTTTGC	0.353													4	13					0	0	0.000602	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172563854	172563854	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:172563854G>A	uc002uha.1	+	5	467	c.302G>A	c.(301-303)AGC>AAC	p.S101N	DYNC1I2_uc002uhc.2_Missense_Mutation_p.S95N|DYNC1I2_uc002uhb.1_Missense_Mutation_p.S95N|DYNC1I2_uc010zds.1_Missense_Mutation_p.S113N|DYNC1I2_uc002uhd.1_Missense_Mutation_p.S95N|DYNC1I2_uc002uhe.1_Missense_Mutation_p.S101N|DYNC1I2_uc002uhf.1_Missense_Mutation_p.S95N|DYNC1I2_uc010zdt.1_Missense_Mutation_p.S113N|DYNC1I2_uc002uhg.1_Missense_Mutation_p.S16N	NM_001378	NP_001369	Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	101					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.198)			GAAGCTGGAAGCCAAGACTCT	0.438													21	37					0	0	0.003330	0	0
GPR155	151556	broad.mit.edu	37	2	175333751	175333751	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:175333751G>A	uc002uit.2	-	6	1462	c.1071C>T	c.(1069-1071)ATC>ATT	p.I357I	GPR155_uc002uiu.2_Silent_p.I357I|GPR155_uc002uiv.2_Silent_p.I357I|GPR155_uc010fqs.2_Silent_p.I357I	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	357	Helical; (Potential).				intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						AAACGTACATGATGGGAGCAG	0.393													27	32					0	0	0.004656	0	0
TTN	7273	broad.mit.edu	37	2	179399168	179399168	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179399168C>T	uc010zfg.1	-	307	94694	c.94470G>A	c.(94468-94470)AGG>AGA	p.R31490R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.R25185R|TTN_uc010zfi.1_Silent_p.R25118R|TTN_uc010zfj.1_Silent_p.R24993R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32417							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCGAGATTTCCTCTCTTTCA	0.413													36	51					0	0	0.004878	0	0
TTN	7273	broad.mit.edu	37	2	179413030	179413030	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179413030A>T	uc010zfg.1	-	288	85843	c.85619T>A	c.(85618-85620)ATT>AAT	p.I28540N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I22235N|TTN_uc010zfi.1_Missense_Mutation_p.I22168N|TTN_uc010zfj.1_Missense_Mutation_p.I22043N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29467							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTGGCTACAATTGGTTCTGG	0.473													66	58					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179448460	179448460	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179448460C>G	uc010zfg.1	-	261	57969	c.57745G>C	c.(57745-57747)GAA>CAA	p.E19249Q	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E12944Q|TTN_uc010zfi.1_Missense_Mutation_p.E12877Q|TTN_uc010zfj.1_Missense_Mutation_p.E12752Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20176							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGTACTCTTCCTGGGGAATC	0.458													10	9					0	0	0.008291	0	0
TTN	7273	broad.mit.edu	37	2	179477031	179477031	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179477031C>T	uc010zfg.1	-	215	42741	c.42517G>A	c.(42517-42519)GAC>AAC	p.D14173N	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D7868N|TTN_uc010zfi.1_Missense_Mutation_p.D7801N|TTN_uc010zfj.1_Missense_Mutation_p.D7676N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15100							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCACAGAGTCCTCAATTTCG	0.448													11	13					0	0	0.008291	0	0
TTN	7273	broad.mit.edu	37	2	179501143	179501144	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179501143_179501144CC>TT	uc010zfg.1	-	174	33830_33831	c.33606_33607GG>AA	c.(33604-33609)ACGGCT>ACAACT	p.A11203T	TTN_uc010zfh.1_Missense_Mutation_p.A4898T|TTN_uc010zfi.1_Missense_Mutation_p.A4831T|TTN_uc010zfj.1_Missense_Mutation_p.A4706T|TTN_uc010fre.1_Missense_Mutation_p.A1064T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12130							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAAGTTTAGCCGTGGAGGTCT	0.351													13	15					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179595861	179595861	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179595861A>C	uc010zfg.1	-	57	14023	c.13799T>G	c.(13798-13800)GTT>GGT	p.V4600G	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V1261G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5527							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAAATTTAACCTGCAAAGT	0.438													52	77					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179649020	179649020	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179649020G>A	uc010zfg.1	-	16	2776	c.2552C>T	c.(2551-2553)TCT>TTT	p.S851F	TTN_uc010zfh.1_Missense_Mutation_p.S805F|TTN_uc010zfi.1_Missense_Mutation_p.S805F|TTN_uc010zfj.1_Missense_Mutation_p.S805F|TTN_uc002unb.2_Missense_Mutation_p.S851F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	851							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTGAGCAGAAGATGTGGC	0.473													13	24					0	0	0.001368	0	0
COL3A1	1281	broad.mit.edu	37	2	189875061	189875061	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:189875061G>A	uc002uqj.1	+	49	4098	c.3981G>A	c.(3979-3981)TGG>TGA	p.W1327*		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1327	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AACACGTTTGGTTTGGAGAGT	0.393													30	29					0	0	0.002836	0	0
WDR75	84128	broad.mit.edu	37	2	190322059	190322059	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:190322059G>A	uc002uql.1	+	6	581	c.521G>A	c.(520-522)CGG>CAG	p.R174Q	WDR75_uc002uqm.1_Missense_Mutation_p.R110Q|WDR75_uc002uqn.1_5'UTR|WDR75_uc002uqo.1_5'UTR	NM_032168	NP_115544	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	174						nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			GCTGCAGTACGGGAATTTTAC	0.229													13	15					0	0	0.008871	0	0
ANKAR	150709	broad.mit.edu	37	2	190593472	190593472	+	Missense_Mutation	SNP	C	T	T	rs149050269		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:190593472C>T	uc002uqw.1	+	14	2905	c.2905C>T	c.(2905-2907)CGC>TGC	p.R969C	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqx.1_RNA|ANKAR_uc002uqy.1_Missense_Mutation_p.R136C	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1040						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			ACCATTGGTTCGCTTACTAAG	0.393													26	29					0	0	0.004656	0	0
DNAH7	56171	broad.mit.edu	37	2	196619129	196619129	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:196619129G>A	uc002utj.3	-	63	11797	c.11696C>T	c.(11695-11697)CCT>CTT	p.P3899L	DNAH7_uc002uti.3_Missense_Mutation_p.P382L	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3899					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AAGATCAATAGGAATTGTGTA	0.483													15	20					0	0	0.003163	0	0
HSPD1	3329	broad.mit.edu	37	2	198353733	198353733	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:198353733A>C	uc002uui.2	-	9	1345	c.1208T>G	c.(1207-1209)GTG>GGG	p.V403G	HSPD1_uc002uuj.2_Missense_Mutation_p.V401G|HSPD1_uc010zgx.1_Missense_Mutation_p.V394G|HSPD1_uc010fsm.2_Missense_Mutation_p.V214G|HSPD1_uc002uuk.2_Missense_Mutation_p.V403G	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	403					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			TACCTTCAGCACAGCCACTCC	0.363													20	41					0	0	0.002299	0	0
PLCL1	5334	broad.mit.edu	37	2	198949641	198949641	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:198949641C>T	uc010fsp.2	+	2	1691	c.1400C>T	c.(1399-1401)TCC>TTC	p.S467F	PLCL1_uc002uuv.3_Missense_Mutation_p.S388F	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	467	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	ACCCATGTTTCCTTTCGAAGT	0.408													9	12					0	0	0.004482	0	0
FAM117B	150864	broad.mit.edu	37	2	203622041	203622041	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:203622041A>C	uc010zhx.1	+	6	1220	c.1210A>C	c.(1210-1212)AGC>CGC	p.S404R		NM_173511	NP_775782	Q6P1L5	F117B_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	404										ovary(1)	1						AGACAGGGGAAGCAACAACAG	0.572													124	188					0	0	0.003610	0	0
GPR1	2825	broad.mit.edu	37	2	207041817	207041817	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:207041817C>T	uc002vbl.3	-	3	541	c.155G>A	c.(154-156)GGA>GAA	p.G52E	GPR1_uc010fue.2_Missense_Mutation_p.G52E|GPR1_uc010fuf.2_Missense_Mutation_p.G52E	NM_005279	NP_005270	P46091	GPR1_HUMAN	G protein-coupled receptor 1	52	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		TCCTGGAATTCCCAGAACAAA	0.463													66	74					0	0	0.003610	0	0
ERBB4	2066	broad.mit.edu	37	2	212483927	212483927	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:212483927G>A	uc002veg.1	-	19	2374	c.2276C>T	c.(2275-2277)CCC>CTC	p.P759L	ERBB4_uc002veh.1_Missense_Mutation_p.P759L|ERBB4_uc010zji.1_Missense_Mutation_p.P749L|ERBB4_uc010zjj.1_Missense_Mutation_p.P749L|ERBB4_uc010fut.1_Missense_Mutation_p.P759L	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	759	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATTTGCCTTGGGACCAGTTGT	0.368										TSP Lung(8;0.080)			18	21					0	0	0.001882	0	0
ABCA12	26154	broad.mit.edu	37	2	215820071	215820071	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:215820071G>A	uc002vew.2	-	43	6468	c.6248C>T	c.(6247-6249)TCC>TTC	p.S2083F	ABCA12_uc002vev.2_Missense_Mutation_p.S1765F|ABCA12_uc010zjn.1_Missense_Mutation_p.S1010F	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2083	Helical; (Potential).				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GTACATCCAGGAAAATGTTGC	0.308													9	12					0	0	0.008291	0	0
TNS1	7145	broad.mit.edu	37	2	218712399	218712399	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:218712399G>A	uc002vgt.2	-	17	2864	c.2466C>T	c.(2464-2466)TTC>TTT	p.F822F	TNS1_uc002vgr.2_Silent_p.F822F|TNS1_uc002vgs.2_Silent_p.F822F|TNS1_uc010zjv.1_Silent_p.F822F|TNS1_uc010fvj.1_Silent_p.F890F|TNS1_uc010fvk.1_Silent_p.F947F|TNS1_uc010fvi.1_Silent_p.F509F	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	822						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGGTCGGAAGGAAGGCAGGCA	0.582													20	26					0	0	0.007413	0	0
CXCR1	3577	broad.mit.edu	37	2	219029795	219029795	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:219029795G>A	uc002vhc.2	-	2	259	c.140C>T	c.(139-141)GCC>GTC	p.A47V		NM_000634	NP_000625	P25024	CXCR1_HUMAN	interleukin 8 receptor alpha	47	Helical; Name=1; (Potential).				dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			lung(2)	2						GAACACTAGGGCATAGGCGAT	0.507													43	68					0	0	0.008740	0	0
PNKD	25953	broad.mit.edu	37	2	219204778	219204778	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:219204778C>T	uc002vhn.2	+	4	523	c.379C>T	c.(379-381)CTC>TTC	p.L127F	PNKD_uc002vhq.2_Missense_Mutation_p.L103F	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	127						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CATCCCTGTCCTCTCGGACAA	0.642													23	20					0	0	0.002780	0	0
C2orf24	27013	broad.mit.edu	37	2	220038093	220038093	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:220038093G>A	uc002vju.3	-	7	821	c.669C>T	c.(667-669)TCC>TCT	p.S223S	C2orf24_uc002vjv.2_Silent_p.S223S	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	223					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTGGCAGAGGGAGCCCAGGG	0.622													19	29					0	0	0.001882	0	0
DES	1674	broad.mit.edu	37	2	220285356	220285356	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:220285356C>T	uc002vll.2	+	4	961	c.875C>T	c.(874-876)GCT>GTT	p.A292V		NM_001927	NP_001918	P17661	DESM_HUMAN	desmin	292	Linker 2.|Rod.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			central_nervous_system(2)	2		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		ATTTCTGAAGCTGAGGAGTGG	0.592													12	23					0	0	0.001855	0	0
STK11IP	114790	broad.mit.edu	37	2	220476456	220476456	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:220476456C>T	uc002vml.2	+	18	2311	c.2268C>T	c.(2266-2268)GTC>GTT	p.V756V		NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	756					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCAGCCCTGTCTGCCACCCTC	0.637													13	16					0	0	0.001855	0	0
SGPP2	130367	broad.mit.edu	37	2	223339404	223339404	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:223339404A>T	uc010zlo.1	+	2	337	c.337A>T	c.(337-339)ATT>TTT	p.I113F	SGPP2_uc010zlp.1_5'UTR	NM_152386	NP_689599	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphotase 2	113					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|skin(1)	2		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		TCACTGGAATATTGACCCTTA	0.348													20	31					0	0	0.001882	0	0
SGPP2	130367	broad.mit.edu	37	2	223386515	223386515	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:223386515G>A	uc010zlo.1	+	3	408	c.408G>A	c.(406-408)AAG>AAA	p.K136K	SGPP2_uc010zlp.1_Silent_p.K8K	NM_152386	NP_689599	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphotase 2	136	Helical; (Potential).				sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|skin(1)	2		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		AAGTGGCCAAGGATGTCTTGA	0.468													25	51					0	0	0.004656	0	0
KIAA1486	57624	broad.mit.edu	37	2	226446676	226446676	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:226446676C>T	uc002voe.2	+	4	718	c.543C>T	c.(541-543)CCC>CCT	p.P181P	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_5'UTR	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	181										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		AACCAAGACCCCACAGCGATG	0.398													42	61					0	0	0.003610	0	0
COL4A4	1286	broad.mit.edu	37	2	227922200	227922200	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:227922200C>T	uc010zlt.1	-	29	3154	c.2500G>A	c.(2500-2502)GGG>AGG	p.G834R		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	834	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCTGGTATCCCTGGAGCACCT	0.473													7	4					0	0	0.003080	0	0
COL4A3	1285	broad.mit.edu	37	2	228162489	228162489	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:228162489G>A	uc002vom.1	+	42	3827	c.3665G>A	c.(3664-3666)GGA>GAA	p.G1222E	COL4A3_uc002von.1_Missense_Mutation_p.G1222E|COL4A3_uc002voo.1_Missense_Mutation_p.G1222E|COL4A3_uc002vop.1_Missense_Mutation_p.G1222E|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1222	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCATAGAAGGATTCCCAGGG	0.602													4	5					0	0	0.000248	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882638	228882638	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:228882638A>C	uc002vpq.2	-	7	2979	c.2932T>G	c.(2932-2934)TCC>GCC	p.S978A	SPHKAP_uc002vpp.2_Missense_Mutation_p.S978A|SPHKAP_uc010zlx.1_Missense_Mutation_p.S978A	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	978						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTCTTCAAGGATCGGCAGGGT	0.547													32	15					0	0	0.002445	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884064	228884064	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:228884064A>G	uc002vpq.2	-	7	1553	c.1506T>C	c.(1504-1506)TGT>TGC	p.C502C	SPHKAP_uc002vpp.2_Silent_p.C502C|SPHKAP_uc010zlx.1_Silent_p.C502C	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	502						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAGTGGCTGCACAAGCTAACG	0.527													8	10					0	0	0.006214	0	0
DNER	92737	broad.mit.edu	37	2	230253045	230253045	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:230253045C>T	uc002vpv.2	-	11	1938	c.1791G>A	c.(1789-1791)CTG>CTA	p.L597L		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	597	Extracellular (Potential).|EGF-like 10; calcium-binding (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGGGCTGGTCCAGGCAGCTCC	0.498													49	76					0	0	0.003610	0	0
DNER	92737	broad.mit.edu	37	2	230453181	230453181	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:230453181C>T	uc002vpv.2	-	3	756	c.609G>A	c.(607-609)GGG>GGA	p.G203G	DNER_uc010zly.1_5'Flank	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	203	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AACTGGCATTCCCACAGGCAA	0.413													13	28					0	0	0.003163	0	0
SP100	6672	broad.mit.edu	37	2	231380341	231380341	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:231380341G>A	uc002vqt.2	+	25	2767	c.2626G>A	c.(2626-2628)GAT>AAT	p.D876N	SP100_uc002vqu.1_Intron|SP100_uc010fxp.1_Intron	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	876					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		aaatgaagaagatgaTGATAA	0.149													9	6					0	0	0.004482	0	0
NMUR1	10316	broad.mit.edu	37	2	232393698	232393698	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:232393698G>A	uc002vry.3	-	2	144	c.34C>T	c.(34-36)CCT>TCT	p.P12S		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	12	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		AGGTCTCCAGGGAGGACAGAG	0.557													6	10					0	0	0.003080	0	0
ALPI	248	broad.mit.edu	37	2	233321866	233321866	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:233321866C>T	uc002vst.3	+	5	559	c.482C>T	c.(481-483)TCA>TTA	p.S161L	ALPI_uc002vsu.3_Missense_Mutation_p.S72L	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	161					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCAGGAAAGTCAGTAGGAGTG	0.627													16	9					0	0	0.004990	0	0
ECEL1	9427	broad.mit.edu	37	2	233350918	233350918	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:233350918G>A	uc002vsv.2	-	2	651	c.446C>T	c.(445-447)ACC>ATC	p.T149I	ECEL1_uc010fya.1_Missense_Mutation_p.T149I|ECEL1_uc010fyb.1_5'UTR	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	149	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGCCGCGATGGTGCCATAGGT	0.562													7	11					0	0	0.003080	0	0
GIGYF2	26058	broad.mit.edu	37	2	233721532	233721532	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:233721532C>T	uc002vti.3	+	31	4199	c.3862C>T	c.(3862-3864)CTC>TTC	p.L1288F	GIGYF2_uc002vtj.3_Missense_Mutation_p.L1309F|GIGYF2_uc002vtk.3_Missense_Mutation_p.L1288F|GIGYF2_uc002vth.3_Missense_Mutation_p.L1282F|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc002vtq.3_Missense_Mutation_p.L621F	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	1288					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		ATCGGAGCGACTCAACATGGG	0.527													21	34					0	0	0.003330	0	0
DGKD	8527	broad.mit.edu	37	2	234355402	234355402	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:234355402C>T	uc002vui.1	+	12	1391	c.1379C>T	c.(1378-1380)TCC>TTC	p.S460F	DGKD_uc002vuj.1_Missense_Mutation_p.S416F|DGKD_uc010fyh.1_Missense_Mutation_p.S327F|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	460					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	CGGCAGGCCTCCTCCTCTACC	0.597													28	34					0	0	0.002096	0	0
UGT1A5	54579	broad.mit.edu	37	2	234622455	234622455	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:234622455T>C	uc002vuw.2	+	1	818	c.818T>C	c.(817-819)ATG>ACG	p.M273T	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Missense_Mutation_p.M273T	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	273					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		ATGCCCAACATGGTCTTCATT	0.502													10	32					0	0	0.002780	0	0
UGT1A4	54657	broad.mit.edu	37	2	234628284	234628284	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:234628284T>C	uc002vux.2	+	1	847	c.818T>C	c.(817-819)ATG>ACG	p.M273T	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Missense_Mutation_p.M273T	NM_007120	NP_009051	P22310	UD14_HUMAN	UDP glycosyltransferase 1 family, polypeptide A4	273					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)	Imipramine(DB00458)|Lamotrigine(DB00555)|Paricalcitol(DB00910)|Trifluoperazine(DB00831)	ATGCCCAACATGGTCTTCATT	0.512													7	93					0	0	0.001855	0	0
COL6A3	1293	broad.mit.edu	37	2	238296801	238296801	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:238296801G>A	uc002vwl.2	-	4	1021	c.736C>T	c.(736-738)CTT>TTT	p.L246F	COL6A3_uc002vwo.2_Missense_Mutation_p.L40F|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Missense_Mutation_p.L40F|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Missense_Mutation_p.L246F	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	246	VWFA 2.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCATCAATAAGGAAAATAATG	0.378													17	32					0	0	0.008871	0	0
ANKMY1	51281	broad.mit.edu	37	2	241459909	241459909	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:241459909C>T	uc002vyz.1	-	8	1836	c.1607G>A	c.(1606-1608)CGG>CAG	p.R536Q	ANKMY1_uc002vza.1_Missense_Mutation_p.R395Q|ANKMY1_uc010fzd.1_Missense_Mutation_p.R625Q|ANKMY1_uc002vzb.1_Missense_Mutation_p.R297Q|ANKMY1_uc002vzc.1_Missense_Mutation_p.R395Q|ANKMY1_uc002vzd.1_Missense_Mutation_p.R395Q	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	536	ANK 2.						zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GTCCGCGCCCCGGCGCAGCAG	0.697													13	12					0	0	0.001855	0	0
ANKMY1	51281	broad.mit.edu	37	2	241463561	241463561	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:241463561G>A	uc002vyz.1	-	7	1535	c.1306C>T	c.(1306-1308)CCG>TCG	p.P436S	ANKMY1_uc002vza.1_Missense_Mutation_p.P295S|ANKMY1_uc010fzd.1_Missense_Mutation_p.P525S|ANKMY1_uc002vzb.1_Intron|ANKMY1_uc002vzc.1_Missense_Mutation_p.P295S|ANKMY1_uc002vzd.1_Missense_Mutation_p.P295S|ANKMY1_uc010fze.1_Missense_Mutation_p.P105S|ANKMY1_uc002vze.2_Missense_Mutation_p.P197S	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	436							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TTCACCAACGGGGAGTCCCCC	0.627													12	9					0	0	0.001368	0	0
ANKMY1	51281	broad.mit.edu	37	2	241494370	241494370	+	Translation_Start_Site	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:241494370C>A	uc002vyz.1	-	2	211	c.-18G>T	c.(-20--16)CAGGA>CATGA		ANKMY1_uc002vza.1_Missense_Mutation_p.Q83H|ANKMY1_uc010fzd.1_Missense_Mutation_p.Q83H|ANKMY1_uc002vzb.1_Missense_Mutation_p.Q83H|ANKMY1_uc002vzc.1_Missense_Mutation_p.Q83H|ANKMY1_uc002vzd.1_Missense_Mutation_p.Q83H|ANKMY1_uc010fze.1_Intron|ANKMY1_uc002vze.2_Translation_Start_Site|ANKMY1_uc002vzf.2_Translation_Start_Site	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1								zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CCTGCCACTCCTGCACACCCT	0.572													47	57					2.01872e-29	3.09493e-29	0.003610	1	0
ANO7	50636	broad.mit.edu	37	2	242149015	242149015	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:242149015C>T	uc002wax.2	+	13	1589	c.1486C>T	c.(1486-1488)CGC>TGC	p.R496C		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	496	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CCGCGCGCGCCGCATGCTGGC	0.677													9	19					0	0	0.006214	0	0
DEFB125	245938	broad.mit.edu	37	20	76862	76862	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:76862C>T	uc002wcw.2	+	2	275	c.275C>T	c.(274-276)CCA>CTA	p.P92L		NM_153325	NP_697020	Q8N687	DB125_HUMAN	defensin, beta 125 preproprotein	92					defense response to bacterium	extracellular region				ovary(1)|central_nervous_system(1)|skin(1)	3		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.156)			ACTGGTTCCCCAGTATCTATG	0.383													27	143					0	0	0.004656	0	0
SNRPB	6628	broad.mit.edu	37	20	2442428	2442428	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:2442428G>A	uc002wfz.1	-	7	860	c.697C>T	c.(697-699)CCG>TCG	p.P233S	SNRPB_uc002wga.1_3'UTR|SNRPB_uc010zpv.1_3'UTR|SNRPB_uc002wgb.2_3'UTR	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	233	Repeat-rich region.|				histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						CGCATTCCCGGGGGAGGGGGC	0.552													17	83					0	0	0.006122	0	0
PTPRA	5786	broad.mit.edu	37	20	3005267	3005267	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3005267G>A	uc010zqd.1	+	16	1964	c.1647G>A	c.(1645-1647)AAG>AAA	p.K549K	PTPRA_uc002whj.2_Silent_p.K538K|PTPRA_uc002whk.2_Silent_p.K529K|PTPRA_uc002whl.2_Silent_p.K529K|PTPRA_uc002whm.2_Silent_p.K305K|PTPRA_uc002whn.2_Silent_p.K529K|PTPRA_uc002who.2_Silent_p.K201K	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	538	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						AGGAGTTTAAGGTGAGTTGGA	0.458													33	70					0	0	0.002445	0	0
FASTKD5	60493	broad.mit.edu	37	20	3127866	3127866	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3127866C>T	uc002whz.2	-	2	2162	c.1851G>A	c.(1849-1851)AGG>AGA	p.R617R	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	617					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						CATGCTCAAGCCTTAATTTGG	0.438													32	120					0	0	0.002096	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3678675	3678675	+	Missense_Mutation	SNP	G	A	A	rs143548718		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3678675G>A	uc002wja.2	-	8	1892	c.1892C>T	c.(1891-1893)CCC>CTC	p.P631L	SIGLEC1_uc002wiz.3_Missense_Mutation_p.P631L	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	631	Ig-like C2-type 6.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CAGCCTGGCGGGGGGGTCGCT	0.667													8	17					0	0	0.003080	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3687199	3687199	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3687199C>T	uc002wja.2	-	2	204	c.204G>A	c.(202-204)CAG>CAA	p.Q68Q	SIGLEC1_uc002wiz.3_Silent_p.Q68Q|SIGLEC1_uc002wjc.2_5'UTR	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	68	Ig-like V-type.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GGCTCACCACCTGCCGCTGGC	0.667													4	18					0	0	0.000248	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3687267	3687267	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3687267G>A	uc002wja.2	-	2	136	c.136C>T	c.(136-138)CCT>TCT	p.P46S	SIGLEC1_uc002wiz.3_Missense_Mutation_p.P46S|SIGLEC1_uc002wjc.2_5'UTR	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	46	Ig-like V-type.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						ACGTCGGCAGGGAAGCTGAAG	0.657													3	11					0	0	0.004672	0	0
MAVS	57506	broad.mit.edu	37	20	3846674	3846674	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3846674C>T	uc002wjw.3	+	7	1672	c.1503C>T	c.(1501-1503)TTC>TTT	p.F501F	MAVS_uc002wjx.3_Silent_p.F360F|MAVS_uc002wjy.3_Silent_p.F199F	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	501	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						ACCGGAAGTTCCAGGAGAGGG	0.672													13	43					0	0	0.001855	0	0
PROKR2	128674	broad.mit.edu	37	20	5283349	5283349	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:5283349C>T	uc010zqw.1	-	2	492	c.492G>A	c.(490-492)CGG>CGA	p.R164R	PROKR2_uc010zqx.1_Silent_p.R164R|PROKR2_uc010zqy.1_Silent_p.R164R	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	164	Cytoplasmic (Potential).		R -> Q (in KAL3).			integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GATAATTCATCCGTGGTTTCA	0.488										HNSCC(71;0.22)			36	131					0	0	0.005524	0	0
CHGB	1114	broad.mit.edu	37	20	5903511	5903511	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:5903511G>A	uc002wmg.2	+	4	1027	c.721G>A	c.(721-723)GAG>AAG	p.E241K	CHGB_uc010zqz.1_5'UTR	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	241						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GGAGAGTGGAGAGGAGACAGG	0.532													11	27					0	0	0.008291	0	0
PLCB1	23236	broad.mit.edu	37	20	8678295	8678295	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:8678295C>T	uc002wnb.2	+	11	1035	c.1032C>T	c.(1030-1032)TCC>TCT	p.S344S	PLCB1_uc010zrb.1_Silent_p.S243S|PLCB1_uc002wna.2_Silent_p.S344S|PLCB1_uc002wnc.1_Silent_p.S243S	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	344	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CTGGAAACTCCTCTGTTGAGA	0.522													34	135					0	0	0.004289	0	0
ANKRD5	63926	broad.mit.edu	37	20	10030785	10030785	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:10030785A>T	uc002wno.2	+	7	1961	c.1568A>T	c.(1567-1569)AAT>ATT	p.N523I	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Missense_Mutation_p.N523I|ANKRD5_uc010gbz.2_Missense_Mutation_p.N334I	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	523							calcium ion binding			ovary(1)|breast(1)	2						ATGAAGGATAATTATTACAAA	0.428													18	54					0	0	0.001523	0	0
JAG1	182	broad.mit.edu	37	20	10629213	10629213	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:10629213G>A	uc002wnw.2	-	12	2069	c.1553C>T	c.(1552-1554)TCT>TTT	p.S518F	JAG1_uc010gcd.1_Missense_Mutation_p.S76F	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	518	EGF-like 8; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GAGGTTTCCAGAGAAACCAGT	0.507									Alagille_Syndrome				16	59					0	0	0.008871	0	0
SEL1L2	80343	broad.mit.edu	37	20	13850798	13850798	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:13850798C>T	uc010gcf.2	-	13	1238	c.1156G>A	c.(1156-1158)GGA>AGA	p.G386R	SEL1L2_uc002woq.3_Missense_Mutation_p.G247R|SEL1L2_uc010zrl.1_Missense_Mutation_p.G386R|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	386	Extracellular (Potential).|Sel1-like 7.					integral to membrane	binding			ovary(2)	2						AGGGGAACTCCTTTTCCATGA	0.333													26	116					0	0	0.004656	0	0
FLRT3	23767	broad.mit.edu	37	20	14306424	14306424	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:14306424C>T	uc002wov.1	-	3	2196	c.1729G>A	c.(1729-1731)GAA>AAA	p.E577K	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.E577K	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	577	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GTGCCAGCTTCTGCATAGTCA	0.428													39	131					0	0	0.006230	0	0
MACROD2	140733	broad.mit.edu	37	20	15967391	15967391	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:15967391G>A	uc002wou.2	+	14	1269	c.1005G>A	c.(1003-1005)ACG>ACA	p.T335T	MACROD2_uc002wot.2_Silent_p.T335T|MACROD2_uc002woz.2_Silent_p.T100T|MACROD2_uc002wpb.2_Silent_p.T100T|MACROD2_uc002wpd.2_5'UTR	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1	335	Glu-rich.										0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				ATGATTCAACGAAGAATGAAA	0.338													10	53					0	0	0.008291	0	0
C20orf79	140856	broad.mit.edu	37	20	18794854	18794854	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:18794854G>A	uc002wrk.2	+	1	485	c.395G>A	c.(394-396)GGA>GAA	p.G132E	uc002wrj.1_Intron	NM_178483	NP_848578	Q9UJQ7	CT079_HUMAN	hypothetical protein LOC140856	132	SCP2.						sterol binding			skin(3)	3						TTCCTTGCCGGAAAGTTCAAA	0.473													17	66					0	0	0.002299	0	0
RIN2	54453	broad.mit.edu	37	20	19956093	19956093	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:19956093C>T	uc002wro.1	+	7	1460	c.1424C>T	c.(1423-1425)CCC>CTC	p.P475L	RIN2_uc010gcu.1_Intron|RIN2_uc010gcv.1_Missense_Mutation_p.P269L	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	475					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						ACCATGGCGCCCCCCATCAAG	0.587													12	56					0	0	0.001368	0	0
C20orf26	26074	broad.mit.edu	37	20	20144803	20144803	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:20144803C>T	uc002wru.2	+	11	1212	c.1136C>T	c.(1135-1137)CCC>CTC	p.P379L	C20orf26_uc010gcw.1_Missense_Mutation_p.P333L|C20orf26_uc010zse.1_Missense_Mutation_p.P379L|C20orf26_uc010zsf.1_Missense_Mutation_p.P379L	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	379										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CACTTCCGCCCCATCTACAGG	0.498													21	91					0	0	0.001882	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20585984	20585984	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:20585984C>T	uc002wrz.2	-	15	2016	c.1873G>A	c.(1873-1875)GGT>AGT	p.G625S	RALGAPA2_uc010gcx.2_Missense_Mutation_p.G329S|RALGAPA2_uc010zsg.1_Missense_Mutation_p.G26S	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	625					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						GACAGCACACCAAGAAAGTCA	0.478													10	54					0	0	0.006214	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492893	21492893	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:21492893G>A	uc002wsi.2	-	2	847	c.490C>T	c.(490-492)CTC>TTC	p.L164F		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	164	Homeobox.				brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						AGGCGGATGAGGCTGGCCAGG	0.657													16	41					0	0	0.004990	0	0
PAX1	5075	broad.mit.edu	37	20	21689305	21689305	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:21689305A>G	uc002wsj.2	+	3	1080	c.1026A>G	c.(1024-1026)AAA>AAG	p.K342K	PAX1_uc010zsl.1_Silent_p.K342K|PAX1_uc010zsm.1_Silent_p.K318K	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	342					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						GGCTAGAGAAACCTGCCTTAG	0.582													13	60					0	0	0.001855	0	0
CST9L	128821	broad.mit.edu	37	20	23549030	23549030	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:23549030C>T	uc002wtk.3	-	1	357	c.58G>A	c.(58-60)GGC>AGC	p.G20S		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	20						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					ATCTGGGAGCCTAAGAGAAGC	0.582													11	30					0	0	0.001855	0	0
ENTPD6	955	broad.mit.edu	37	20	25203577	25203577	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:25203577C>T	uc002wuj.2	+	12	1329	c.1149C>T	c.(1147-1149)TCC>TCT	p.S383S	ENTPD6_uc010zsz.1_Silent_p.S165S|ENTPD6_uc002wum.2_Silent_p.S366S|ENTPD6_uc010zta.1_Silent_p.S383S|ENTPD6_uc002wun.2_Silent_p.S349S|ENTPD6_uc002wuk.2_Silent_p.S382S|ENTPD6_uc002wul.2_Silent_p.S382S|ENTPD6_uc010ztb.1_Silent_p.S355S|ENTPD6_uc010ztc.1_Silent_p.S355S|ENTPD6_uc002wuo.2_Silent_p.S135S|ENTPD6_uc010ztd.1_Silent_p.S131S|ENTPD6_uc010gdk.1_RNA|ENTPD6_uc010gdl.1_RNA	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	383	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						ATGCTTTCTCCTACTATTACG	0.607													34	142					0	0	0.002222	0	0
DEFB115	245929	broad.mit.edu	37	20	29845498	29845498	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:29845498G>A	uc002wvp.1	+	1	32	c.32G>A	c.(31-33)GGA>GAA	p.G11E		NM_001037730	NP_001032819	Q30KQ5	DB115_HUMAN	beta-defensin 115 precursor	11					defense response to bacterium	extracellular region				ovary(1)	1			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			CCCCTCTCAGGAGACATTAAA	0.512													20	57					0	0	0.001523	0	0
BCL2L1	598	broad.mit.edu	37	20	30309749	30309749	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:30309749C>T	uc002wwl.2	-	2	639	c.273G>A	c.(271-273)AGG>AGA	p.R91R	BCL2L1_uc002wwk.2_RNA|BCL2L1_uc002wwm.2_Silent_p.R91R|BCL2L1_uc002wwn.2_Silent_p.R91R|BCL2L1_uc002wwo.1_Silent_p.R91R	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	BCL2-like 1 isoform 1	91	BH3.				induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			lung(1)|central_nervous_system(1)	2	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			CGCCTGCCTCCCTCAGCGCTT	0.607													18	66					0	0	0.003330	0	0
TM9SF4	9777	broad.mit.edu	37	20	30747839	30747839	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:30747839C>T	uc002wxj.2	+	16	1849	c.1614C>T	c.(1612-1614)TTC>TTT	p.F538F	TM9SF4_uc010zts.1_Silent_p.F445F|TM9SF4_uc002wxk.2_Silent_p.F521F|TM9SF4_uc010gdz.2_Silent_p.F417F	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	538	Helical; (Potential).					integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCTTCCTGTTCCTTGTTTTCA	0.542													24	62					0	0	0.002780	0	0
SUN5	140732	broad.mit.edu	37	20	31583448	31583448	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:31583448C>T	uc002wyi.2	-	8	604	c.511G>A	c.(511-513)GAG>AAG	p.E171K		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	171	Potential.				spermatogenesis					skin(1)	1						GCTTCCATCTCCTGGAGCTTG	0.423													72	235					0	0	0.003610	0	0
BPIL1	80341	broad.mit.edu	37	20	31606475	31606475	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:31606475C>T	uc002wyj.2	+	9	896	c.702C>T	c.(700-702)ATC>ATT	p.I234I		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	234						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						AGCCCATCATCCTGCCCACGG	0.632													37	142					0	0	0.002222	0	0
C20orf186	149954	broad.mit.edu	37	20	31671494	31671494	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:31671494G>A	uc010zue.1	+	3	506	c.491G>A	c.(490-492)GGG>GAG	p.G164E		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	164	Gly-rich.					cytoplasm|extracellular region	lipid binding				0						GTTGCCACTGGGGCGGTGGGC	0.677													20	59					0	0	0.008871	0	0
NCOA6	23054	broad.mit.edu	37	20	33345249	33345250	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:33345249_33345250GG>AA	uc002xav.2	-	8	3872_3873	c.1301_1302CC>TT	c.(1300-1302)TCC>TTT	p.S434F	NCOA6_uc002xaw.2_Missense_Mutation_p.S434F|NCOA6_uc010gew.1_Missense_Mutation_p.S391F	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	434	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CCTGCTGGAAGGAGGAGGGTGA	0.584													16	63					0	0	0.004672	0	0
GSS	2937	broad.mit.edu	37	20	33519905	33519905	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:33519905G>A	uc002xbg.2	-	10	946	c.866C>T	c.(865-867)TCA>TTA	p.S289L	GSS_uc010zun.1_Missense_Mutation_p.S161L|GSS_uc010zuo.1_Missense_Mutation_p.S178L|GSS_uc010zup.1_Missense_Mutation_p.S220L|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_Missense_Mutation_p.S19L	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	289					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	GGCAGCATGTGACCTCTCCAG	0.468													30	117					0	0	0.003755	0	0
EDEM2	55741	broad.mit.edu	37	20	33725685	33725685	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:33725685G>A	uc002xbo.2	-	5	588	c.488C>T	c.(487-489)CCA>CTA	p.P163L	EDEM2_uc010zuv.1_Missense_Mutation_p.P122L|EDEM2_uc010zus.1_5'UTR|EDEM2_uc002xbq.2_Missense_Mutation_p.P126L|EDEM2_uc010zut.1_Missense_Mutation_p.P122L|EDEM2_uc002xbp.2_Missense_Mutation_p.P11L|EDEM2_uc002xbn.2_Missense_Mutation_p.P11L|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_Intron	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	163					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GGTCTTACCTGGGAGGAGTTT	0.562													22	64					0	0	0.001882	0	0
MMP24	10893	broad.mit.edu	37	20	33842507	33842507	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:33842507C>T	uc002xbu.2	+	4	770	c.767C>T	c.(766-768)ACC>ATC	p.T256I	EDEM2_uc010zuv.1_Intron	NM_006690	NP_006681	Q9Y5R2	MMP24_HUMAN	matrix metalloproteinase 24 preproprotein	256	Extracellular (Potential).				proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GGAGGAGACACCCACTTTGAC	0.562													36	123					0	0	0.005524	0	0
GDF5	8200	broad.mit.edu	37	20	34021839	34021839	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:34021839G>A	uc010gfc.1	-	2	1615	c.1374C>T	c.(1372-1374)CCC>CCT	p.P458P	uc002xcj.2_Missense_Mutation_p.G84R|GDF5_uc002xck.1_Silent_p.P458P|GDF5_uc010zvc.1_Silent_p.P458P	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	458					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GTGTGGACTCGGGGTCCATGG	0.582													10	38					0	0	0.001368	0	0
CEP250	11190	broad.mit.edu	37	20	34055193	34055193	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:34055193C>A	uc002xcm.2	+	10	1335	c.664C>A	c.(664-666)CGC>AGC	p.R222S	CEP250_uc010zve.1_5'UTR|CEP250_uc010zvd.1_RNA|CEP250_uc002xco.2_Missense_Mutation_p.R29S	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	222					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CTGTTGTCTGCGCTTGACTGT	0.552													43	129					3.77016e-25	5.7722e-25	0.003214	1	0
DLGAP4	22839	broad.mit.edu	37	20	35060160	35060160	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:35060160G>A	uc002xff.2	+	3	475	c.40G>A	c.(40-42)GAC>AAC	p.D14N	DLGAP4_uc010zvp.1_Missense_Mutation_p.D14N	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	14					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCACCTCTCCGACAGCCTAGA	0.726													9	33					0	0	0.004482	0	0
SLA2	84174	broad.mit.edu	37	20	35242336	35242336	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:35242336C>T	uc002xfv.2	-	8	1081	c.719G>A	c.(718-720)GGT>GAT	p.G240D	SLA2_uc002xfu.2_3'UTR	NM_032214	NP_115590	Q9H6Q3	SLAP2_HUMAN	Src-like-adaptor 2 isoform a	240	SLA C-terminal.				antigen receptor-mediated signaling pathway|B cell mediated immunity|intracellular receptor mediated signaling pathway|negative regulation of B cell activation|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|T cell activation	cytoplasmic membrane-bounded vesicle|endosome membrane|plasma membrane	protein N-terminus binding|SH3/SH2 adaptor activity				0	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				CTCCCGGAGACCCTCACTGAG	0.542													18	53					0	0	0.006122	0	0
KIAA0406	9675	broad.mit.edu	37	20	36640943	36640943	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:36640943G>A	uc002xhl.2	-	3	1485	c.1276C>T	c.(1276-1278)CAG>TAG	p.Q426*	KIAA0406_uc002xhm.2_Nonsense_Mutation_p.Q426*	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	426							binding				0		Myeloproliferative disorder(115;0.00874)				GAAAGCCGCTGGAGATGGGCC	0.458													16	75					0	0	0.004990	0	0
BPI	671	broad.mit.edu	37	20	36932652	36932652	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:36932652G>A	uc002xib.2	+	1	101	c.39G>A	c.(37-39)CCG>CCA	p.P13P		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	13					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				GCAACGCGCCGAGATGGGCGT	0.617													22	116					0	0	0.003954	0	0
ACTR5	79913	broad.mit.edu	37	20	37400291	37400291	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:37400291C>T	uc002xjd.2	+	9	1681	c.1656C>T	c.(1654-1656)ATC>ATT	p.I552I		NM_024855	NP_079131	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog	552					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding				0		Myeloproliferative disorder(115;0.00878)				AAGTTTGGATCACCAGGAAAG	0.527													11	84					0	0	0.008291	0	0
ZHX3	23051	broad.mit.edu	37	20	39830930	39830930	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:39830930G>A	uc002xjs.1	-	3	3005	c.2627C>T	c.(2626-2628)TCC>TTC	p.S876F	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.S876F|ZHX3_uc002xjt.1_Missense_Mutation_p.S876F|ZHX3_uc002xju.1_Missense_Mutation_p.S876F|ZHX3_uc002xjv.1_Missense_Mutation_p.S876F|ZHX3_uc002xjw.1_Missense_Mutation_p.S876F|ZHX3_uc010ggg.1_Missense_Mutation_p.S876F	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	876	Homeobox 5.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				GACCTGCTGGGAGCTCATCTG	0.577													45	120					0	0	0.002522	0	0
CHD6	84181	broad.mit.edu	37	20	40054786	40054786	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:40054786G>A	uc002xka.1	-	28	4254	c.4076C>T	c.(4075-4077)TCC>TTC	p.S1359F		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1359					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TCCATCACTGGAACTCTCCTA	0.453													48	124					0	0	0.003610	0	0
PTPRT	11122	broad.mit.edu	37	20	40770640	40770640	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:40770640G>A	uc002xkg.2	-	18	2869	c.2685C>T	c.(2683-2685)GCC>GCT	p.A895A	PTPRT_uc010ggj.2_Silent_p.A914A|PTPRT_uc010ggi.2_Silent_p.A98A	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	895	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCTCTGGTAAGGCCTAAAAAG	0.502													43	83					0	0	0.008740	0	0
PTPRT	11122	broad.mit.edu	37	20	41306605	41306605	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:41306605G>A	uc002xkg.2	-	7	1238	c.1054C>T	c.(1054-1056)CCC>TCC	p.P352S	PTPRT_uc010ggj.2_Missense_Mutation_p.P352S	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	352	Extracellular (Potential).|Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCAACATCGGGGTCCAGATGC	0.597													29	69					0	0	0.007291	0	0
TOX2	84969	broad.mit.edu	37	20	42682973	42682973	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:42682973G>A	uc002xlf.3	+	5	730	c.713G>A	c.(712-714)GGA>GAA	p.G238E	TOX2_uc010ggo.2_Missense_Mutation_p.G229E|TOX2_uc002xle.3_Missense_Mutation_p.G187E|TOX2_uc010ggp.2_Missense_Mutation_p.G187E|TOX2_uc002xlg.2_Missense_Mutation_p.G187E|TOX2_uc010zwk.1_Missense_Mutation_p.G107E	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	238	Nuclear localization signal (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GCCGACCCAGGAAAAAAGGCC	0.537													6	12					0	0	0.001168	0	0
JPH2	57158	broad.mit.edu	37	20	42744361	42744361	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:42744361T>C	uc002xli.1	-	4	2827	c.1954A>G	c.(1954-1956)AAG>GAG	p.K652E		NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	652	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CGCGCCTTCTTCTTGGCCCCC	0.612													10	35					0	0	0.000978	0	0
SLC12A5	57468	broad.mit.edu	37	20	44672558	44672558	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:44672558C>T	uc010zxl.1	+	11	1525	c.1449C>T	c.(1447-1449)GTC>GTT	p.V483V	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Silent_p.V460V	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	483	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TTGAGGGGGTCGTCCTGCGGG	0.557													31	85					0	0	0.003271	0	0
SLC12A5	57468	broad.mit.edu	37	20	44676132	44676132	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:44676132C>T	uc010zxl.1	+	15	1972	c.1896C>T	c.(1894-1896)CTC>CTT	p.L632L	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Silent_p.L609L	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	632	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCCTGGCCCTCATGTTCATCT	0.502													48	98					0	0	0.003610	0	0
CD40	958	broad.mit.edu	37	20	44750951	44750951	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:44750951C>T	uc002xrg.1	+	3	287	c.210C>T	c.(208-210)ACC>ACT	p.T70T	CD40_uc002xrf.1_Silent_p.T70T|CD40_uc002xrh.1_Silent_p.T70T|CD40_uc002xri.1_Silent_p.T70T|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	70	TNFR-Cys 2.|Extracellular (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	TCCTAGACACCTGGAACAGAG	0.478									Immune_Deficiency_with_Hyper-IgM				19	55					0	0	0.008871	0	0
ELMO2	63916	broad.mit.edu	37	20	44999142	44999142	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:44999142G>A	uc002xrt.1	-	20	2034	c.1824C>T	c.(1822-1824)GCC>GCT	p.A608A	ELMO2_uc010zxq.1_Silent_p.A340A|ELMO2_uc002xrs.1_Silent_p.A355A|ELMO2_uc002xru.1_Silent_p.A608A|ELMO2_uc010zxr.1_Silent_p.A620A|ELMO2_uc010zxs.1_Silent_p.A425A|ELMO2_uc002xrv.1_Silent_p.A327A	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	608	PH.				apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CAGTGACAATGGCCTTAATGT	0.473													27	87					0	0	0.002836	0	0
PREX1	57580	broad.mit.edu	37	20	47267430	47267430	+	Splice_Site	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:47267430A>C	uc002xtw.1	-	23	2840	c.2817_splice	c.e23+1	p.E939_splice	PREX1_uc002xtv.1_Splice_Site_p.E236_splice	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,						actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCACGCAGGCACCTCCTGGTA	0.488													15	24					0	0	0.004007	0	0
KCNB1	3745	broad.mit.edu	37	20	47989747	47989747	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:47989747G>A	uc002xur.1	-	2	2514	c.2350C>T	c.(2350-2352)CCG>TCG	p.P784S	KCNB1_uc002xus.1_Missense_Mutation_p.P784S	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	784	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTGAACTTCGGACTGGTGCTC	0.537													113	289					0	0	0.003610	0	0
KCNB1	3745	broad.mit.edu	37	20	47989959	47989959	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:47989959A>G	uc002xur.1	-	2	2302	c.2138T>C	c.(2137-2139)CTT>CCT	p.L713P	KCNB1_uc002xus.1_Missense_Mutation_p.L713P	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	713	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTTGTCCAAAAGCGTGGCACA	0.597													17	41					0	0	0.004990	0	0
MOCS3	27304	broad.mit.edu	37	20	49576006	49576006	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:49576006G>A	uc002xvy.1	+	1	644	c.627G>A	c.(625-627)GAG>GAA	p.E209E	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	209					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						TGCGCTTCGAGGGCCAAATCA	0.617													18	59					0	0	0.008871	0	0
KCNG1	3755	broad.mit.edu	37	20	49621209	49621209	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:49621209C>T	uc002xwa.3	-	3	1204	c.909G>A	c.(907-909)CTG>CTA	p.L303L		NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	303	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						CCAGGTCGATCAGCGTCAGCG	0.677													4	10					0	0	0.000602	0	0
ATP9A	10079	broad.mit.edu	37	20	50226668	50226668	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:50226668G>A	uc002xwg.1	-	24	2608	c.2608C>T	c.(2608-2610)CCT>TCT	p.P870S	ATP9A_uc010gih.1_Missense_Mutation_p.P734S|ATP9A_uc002xwf.1_Missense_Mutation_p.P42S	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	870	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TGATAGAGAGGGACGGAGGCA	0.423													21	74					0	0	0.003954	0	0
ZNF831	128611	broad.mit.edu	37	20	57769544	57769544	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:57769544G>A	uc002yan.2	+	1	3470	c.3470G>A	c.(3469-3471)GGG>GAG	p.G1157E		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1157						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCCCACTCAGGGACGTCCCGG	0.677													16	49					0	0	0.001523	0	0
PHACTR3	116154	broad.mit.edu	37	20	58330342	58330342	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:58330342G>A	uc002yau.2	+	4	931	c.464G>A	c.(463-465)GGA>GAA	p.G155E	PHACTR3_uc002yat.2_Missense_Mutation_p.G152E|PHACTR3_uc010zzw.1_Missense_Mutation_p.G114E|PHACTR3_uc002yav.2_Missense_Mutation_p.G114E|PHACTR3_uc002yaw.2_Missense_Mutation_p.G114E|PHACTR3_uc002yax.2_Missense_Mutation_p.G114E	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	155						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GCCCAGCCCGGAAGCCCCTTG	0.602													8	22					0	0	0.004482	0	0
TAF4	6874	broad.mit.edu	37	20	60578892	60578892	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:60578892G>A	uc002ybs.2	-	8	2266	c.2266C>T	c.(2266-2268)CCG>TCG	p.P756S		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	756					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			GTCACCTGCGGGGGCCGGATC	0.652													13	26					0	0	0.006122	0	0
LSM14B	149986	broad.mit.edu	37	20	60701364	60701364	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:60701364C>T	uc010gjy.1	+	3	502	c.296C>T	c.(295-297)TCC>TTC	p.S99F	LSM14B_uc002ybt.2_Missense_Mutation_p.S99F|LSM14B_uc010gjx.1_Missense_Mutation_p.S125F|LSM14B_uc002ybv.2_Missense_Mutation_p.S99F|LSM14B_uc010gjz.1_5'UTR|LSM14B_uc010zzz.1_5'UTR	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	99					multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			GTTCAGTCTTCCCTGGGTTCT	0.652													10	23					0	0	0.001368	0	0
OGFR	11054	broad.mit.edu	37	20	61444274	61444274	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:61444274C>A	uc002ydj.2	+	7	1342	c.1307C>A	c.(1306-1308)CCT>CAT	p.P436H	OGFR_uc002ydk.2_Missense_Mutation_p.P419H|OGFR_uc002ydl.2_Missense_Mutation_p.P384H|uc011aam.1_Missense_Mutation_p.Q123H	NM_007346	NP_031372	Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	436					regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity				0	Breast(26;3.65e-08)					GGTCAGGACCCTGGGGAGGCA	0.662													17	26					0.00498961	0.00753267	0.004990	1	0
PRIC285	85441	broad.mit.edu	37	20	62195450	62195450	+	Silent	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:62195450G>C	uc002yfm.2	-	9	5617	c.4725C>G	c.(4723-4725)CCC>CCG	p.P1575P	PRIC285_uc002yfl.1_Silent_p.P1006P	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1575					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GCAGTGACAGGGGCACCCGGT	0.711													3	12					0	0	0.004672	0	0
PRIC285	85441	broad.mit.edu	37	20	62195558	62195558	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:62195558G>A	uc002yfm.2	-	9	5509	c.4617C>T	c.(4615-4617)TTC>TTT	p.F1539F	PRIC285_uc002yfl.1_Silent_p.F970F	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1539					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TGCCCACCAGGAACTCAGCCA	0.637													6	14					0	0	0.001984	0	0
PRIC285	85441	broad.mit.edu	37	20	62200328	62200328	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:62200328G>A	uc002yfm.2	-	6	2005	c.1113C>T	c.(1111-1113)TTC>TTT	p.F371F	PRIC285_uc002yfl.1_5'Flank	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	371					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CCGTCTTCAGGAACACCTGGC	0.677													11	35					0	0	0.001368	0	0
DNAJC5	80331	broad.mit.edu	37	20	62560684	62560684	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:62560684C>T	uc002yhf.2	+	3	297	c.127C>T	c.(127-129)CAC>TAC	p.H43Y	DNAJC5_uc002yhg.1_Missense_Mutation_p.H43Y|DNAJC5_uc002yhh.2_RNA	NM_025219	NP_079495	Q9H3Z4	DNJC5_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	43	J.				neurotransmitter secretion|protein folding	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|melanosome|plasma membrane	heat shock protein binding|unfolded protein binding			pancreas(1)	1	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CTTGAAATATCACCCCGACAA	0.582													7	21					0	0	0.001984	0	0
NRIP1	8204	broad.mit.edu	37	21	16337281	16337281	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:16337281G>A	uc002yjx.2	-	4	3831	c.3233C>T	c.(3232-3234)TCT>TTT	p.S1078F		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	1078					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		ACTGGTAACAGAATTGCCTCC	0.418													34	135					0	0	0.005524	0	0
CHODL	140578	broad.mit.edu	37	21	19629303	19629303	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:19629303G>A	uc002ykv.2	+	3	797	c.406G>A	c.(406-408)GAA>AAA	p.E136K	CHODL_uc002ykr.2_Missense_Mutation_p.E95K|CHODL_uc002yks.2_Missense_Mutation_p.E95K|CHODL_uc002ykt.2_Missense_Mutation_p.E95K|CHODL_uc002yku.2_Missense_Mutation_p.E95K	NM_024944	NP_079220	Q9H9P2	CHODL_HUMAN	chondrolectin precursor	136	Extracellular (Potential).|C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding	p.E136*(1)		upper_aerodigestive_tract(1)	1		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		GTACACAGATGAACCTTCCTG	0.463													21	40					0	0	0.001882	0	0
ATP5J	522	broad.mit.edu	37	21	27102074	27102074	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:27102074G>A	uc002yls.2	-	2	705	c.32C>T	c.(31-33)TCT>TTT	p.S11F	ATP5J_uc002ylt.2_Missense_Mutation_p.S11F|ATP5J_uc002ylu.2_Missense_Mutation_p.S11F|ATP5J_uc002ylv.2_Missense_Mutation_p.S19F|ATP5J_uc002ylw.2_Missense_Mutation_p.S11F	NM_001685	NP_001676	P18859	ATP5J_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	11					ATP catabolic process|respiratory electron transport chain		hydrogen ion transmembrane transporter activity				0						CCGAATGACAGAGGAGAACCT	0.393													18	18					0	0	0.001882	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28210437	28210437	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:28210437C>G	uc002ymf.2	-	9	2820	c.2365G>C	c.(2365-2367)GAG>CAG	p.E789Q		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	789	Spacer.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		ATGTCTTGCTCTAAGGTGGAC	0.483													18	11					0	0	0.006122	0	0
KRTAP19-8	728299	broad.mit.edu	37	21	32410611	32410611	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:32410611G>A	uc010glt.2	-	1	185	c.152C>T	c.(151-153)CCA>CTA	p.P51L		NM_001099219	NP_001092689	Q3LI54	KR198_HUMAN	keratin associated protein 19-8	51						intermediate filament				upper_aerodigestive_tract(1)	1						GTAGTATAATGGTCGGCAACA	0.493													39	103					0	0	0.007835	0	0
TIAM1	7074	broad.mit.edu	37	21	32554872	32554872	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:32554872G>A	uc002yow.1	-	16	3225	c.2753C>T	c.(2752-2754)CCC>CTC	p.P918L	TIAM1_uc011adk.1_Missense_Mutation_p.P918L|TIAM1_uc011adl.1_Missense_Mutation_p.P858L	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	918					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GCCCAGCGAGGGCTGTGAGAG	0.597													24	47					0	0	0.003330	0	0
TIAM1	7074	broad.mit.edu	37	21	32639272	32639272	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:32639272C>T	uc002yow.1	-	5	489	c.17G>A	c.(16-18)AGT>AAT	p.S6N	TIAM1_uc011adk.1_Missense_Mutation_p.S6N|TIAM1_uc011adl.1_Missense_Mutation_p.S6N|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	6					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TACATGTTGACTTTCTGCGTT	0.532													15	55					0	0	0.006122	0	0
C21orf63	59271	broad.mit.edu	37	21	33887342	33887342	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:33887342C>T	uc002ypr.1	+	8	1578	c.1168C>T	c.(1168-1170)CTG>TTG	p.L390L	C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Silent_p.L387L|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Silent_p.L295L|C21orf63_uc011adq.1_Silent_p.N89N	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	390	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3						CCCAGGGGAACTGTCGGGGTT	0.532													26	45					0	0	0.003954	0	0
SYNJ1	8867	broad.mit.edu	37	21	34011387	34011387	+	Missense_Mutation	SNP	G	T	T	rs149288077	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:34011387G>T	uc002yqh.2	-	31	3863	c.3863C>A	c.(3862-3864)CCG>CAG	p.P1288Q	SYNJ1_uc011ads.1_Missense_Mutation_p.P1202Q|SYNJ1_uc002yqf.2_Missense_Mutation_p.P1233Q|SYNJ1_uc002yqg.2_Missense_Mutation_p.P1202Q|SYNJ1_uc002yqi.2_Missense_Mutation_p.P1288Q|SYNJ1_uc002yqe.3_5'UTR	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1249	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						AGAAGACTGCGGAGGAAAAGC	0.498													27	81					6.07407e-21	9.28683e-21	0.007291	1	0
DONSON	29980	broad.mit.edu	37	21	34958419	34958419	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:34958419C>G	uc002ysk.2	-	3	538	c.471G>C	c.(469-471)TGG>TGC	p.W157C	DONSON_uc002ysn.1_Missense_Mutation_p.W40C|DONSON_uc002ysi.1_5'UTR|DONSON_uc002ysj.2_5'UTR|DONSON_uc002ysl.2_Intron|DONSON_uc010gme.2_Missense_Mutation_p.W130C|DONSON_uc002ysm.2_Missense_Mutation_p.W157C	NM_017613	NP_060083	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	157					multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2						TTTTAATACTCCAGTCCACAG	0.418											OREG0003565	type=REGULATORY REGION|Gene=DONSON|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	19					0	0	0.001984	0	0
TTC3	7267	broad.mit.edu	37	21	38512909	38512909	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:38512909C>T	uc002yvz.2	+	20	1813	c.1708C>T	c.(1708-1710)CCC>TCC	p.P570S	TTC3_uc011aee.1_Missense_Mutation_p.P260S|TTC3_uc002ywa.2_Missense_Mutation_p.P570S|TTC3_uc002ywb.2_Missense_Mutation_p.P570S|TTC3_uc010gnf.2_Missense_Mutation_p.P335S|TTC3_uc002ywc.2_Missense_Mutation_p.P260S|TTC3_uc011aed.1_Missense_Mutation_p.P260S|TTC3_uc010gne.1_Missense_Mutation_p.P570S	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	570	TPR 3.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TGAACACTACCCCAGTGAGGG	0.368													48	69					0	0	0.003610	0	0
MX2	4600	broad.mit.edu	37	21	42767611	42767611	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:42767611G>A	uc002yzf.1	+	7	1073	c.969G>A	c.(967-969)ATG>ATA	p.M323I	MX2_uc011aer.1_RNA|MX2_uc002yzg.1_Missense_Mutation_p.M46I	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	323					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AGGGCTACATGATTGTGAAGT	0.488													17	28					0	0	0.008871	0	0
MX2	4600	broad.mit.edu	37	21	42778893	42778893	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:42778893G>A	uc002yzf.1	+	13	1977	c.1873G>A	c.(1873-1875)GAA>AAA	p.E625K	MX2_uc002yzg.1_Missense_Mutation_p.E348K|MX2_uc010gop.1_Missense_Mutation_p.E107K	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	625	GED.				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				CTCCTTTACTGAAATAGGCAT	0.488													17	23					0	0	0.007413	0	0
UMODL1	89766	broad.mit.edu	37	21	43504239	43504239	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:43504239C>T	uc002zaf.1	+	3	365	c.365C>T	c.(364-366)CCC>CTC	p.P122L	UMODL1_uc002zad.1_Missense_Mutation_p.P50L|UMODL1_uc002zae.1_Missense_Mutation_p.P50L|UMODL1_uc002zag.1_Missense_Mutation_p.P122L|UMODL1_uc010gow.1_5'Flank|UMODL1_uc002zai.1_5'Flank|UMODL1_uc010gox.1_5'Flank|UMODL1_uc010goy.1_5'Flank|UMODL1_uc002zaj.1_5'Flank|UMODL1_uc010goz.1_5'Flank	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	122	Extracellular (Potential).|WAP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						GGGGCCTGCCCCGCAGAGGGG	0.562													49	50					0	0	0.003610	0	0
ABCG1	9619	broad.mit.edu	37	21	43711712	43711712	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:43711712C>T	uc002zaq.2	+	13	1741	c.1635C>T	c.(1633-1635)TCC>TCT	p.S545S	ABCG1_uc002zan.2_Silent_p.S535S|ABCG1_uc002zam.2_Silent_p.S511S|ABCG1_uc002zao.2_Silent_p.S530S|ABCG1_uc002zap.2_Silent_p.S533S|ABCG1_uc002zar.2_Silent_p.S544S|ABCG1_uc011aev.1_Silent_p.S556S|ABCG1_uc010gpb.1_Missense_Mutation_p.P186S	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	545	Helical; (Potential).|ABC transmembrane type-2.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	CCATGACCTCCCTGGTGGCAC	0.662													7	9					0	0	0.001984	0	0
PDE9A	5152	broad.mit.edu	37	21	44174108	44174108	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:44174108C>T	uc002zbm.2	+	10	807	c.744C>T	c.(742-744)CTC>CTT	p.L248L	PDE9A_uc002zbn.2_Silent_p.L121L|PDE9A_uc002zbo.2_Silent_p.L195L|PDE9A_uc002zbp.2_Silent_p.L41L|PDE9A_uc002zbq.2_Silent_p.L146L|PDE9A_uc002zbs.2_Silent_p.L41L|PDE9A_uc002zbr.2_Silent_p.L41L|PDE9A_uc002zbt.2_Silent_p.L120L|PDE9A_uc002zbu.2_Silent_p.L114L|PDE9A_uc002zbv.2_Silent_p.L88L|PDE9A_uc002zbw.2_Silent_p.L31L|PDE9A_uc002zbx.2_Silent_p.L188L|PDE9A_uc002zby.2_Silent_p.L31L|PDE9A_uc002zbz.2_Silent_p.L140L|PDE9A_uc002zca.2_Silent_p.L207L|PDE9A_uc002zcb.2_Silent_p.L222L|PDE9A_uc002zcc.2_Silent_p.L147L|PDE9A_uc002zcd.2_Silent_p.L162L|PDE9A_uc002zce.2_Silent_p.L181L|PDE9A_uc002zcf.2_Silent_p.L41L|PDE9A_uc002zcg.2_Silent_p.L41L|PDE9A_uc002zch.2_Silent_p.L31L|PDE9A_uc010gpf.1_Silent_p.L41L	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	248					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						AGTACCTGCTCTCTCCAGAGA	0.577													6	13					0	0	0.003080	0	0
RRP1B	23076	broad.mit.edu	37	21	45094543	45094543	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:45094543C>T	uc002zdk.2	+	5	498	c.384C>T	c.(382-384)TCC>TCT	p.S128S		NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	128					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		TGAGGCAGTCCTTTGAAGTCT	0.333													10	16					0	0	0.002450	0	0
DNMT3L	29947	broad.mit.edu	37	21	45681098	45681098	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:45681098C>T	uc002zeg.1	-	2	529	c.45G>A	c.(43-45)ATG>ATA	p.M15I	DNMT3L_uc002zeh.1_Missense_Mutation_p.M15I	NM_175867	NP_787063	Q9UJW3	DNM3L_HUMAN	cytosine-5-methyltransferase 3-like protein	15					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			skin(2)	2				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		AAATCACGTCCATGCTGGGCT	0.597													24	40					0	0	0.003330	0	0
C21orf29	54084	broad.mit.edu	37	21	45941911	45941911	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:45941911G>A	uc002zfe.1	-	9	1487	c.1421C>T	c.(1420-1422)TCC>TTC	p.S474F	C21orf29_uc010gpv.1_Missense_Mutation_p.S406F	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	474	EAR 4.				cell adhesion	extracellular region	structural molecule activity				0						GTAGGCGCCGGAGGTGGCGAT	0.607													51	63					0	0	0.003610	0	0
KRTAP10-1	386677	broad.mit.edu	37	21	45959332	45959332	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:45959332G>A	uc002zfh.1	-	1	747	c.702C>T	c.(700-702)CTC>CTT	p.L234L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198691	NP_941964	P60331	KR101_HUMAN	keratin associated protein 10-1	234	24 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						GGCGGCAGAGGAGGGACACGG	0.687													21	19					0	0	0.002299	0	0
KRTAP12-4	386684	broad.mit.edu	37	21	46074232	46074232	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:46074232G>A	uc002zfs.1	-	1	345	c.300C>T	c.(298-300)GTC>GTT	p.V100V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198698	NP_941971	P60329	KR124_HUMAN	keratin associated protein 12-4	100	15.|15 X 5 AA approximate repeats.					keratin filament				ovary(1)	1						CAGGTCTATAGACCAGGGTGG	0.612													13	23					0	0	0.002450	0	0
KRTAP10-12	386685	broad.mit.edu	37	21	46117527	46117527	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:46117527C>T	uc002zfw.1	+	1	441	c.411C>T	c.(409-411)TGC>TGT	p.C137C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198699	NP_941972	P60413	KR10C_HUMAN	keratin associated protein 10-12	137	19 X 5 AA repeats of C-C-X(3).					keratin filament					0						AGTCTAGCTGCCAGCCAGCTT	0.617													41	47					0	0	0.006230	0	0
ADARB1	104	broad.mit.edu	37	21	46596181	46596181	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:46596181C>T	uc002zgy.2	+	4	1000	c.565C>T	c.(565-567)CCC>TCC	p.P189S	ADARB1_uc002zgr.2_Missense_Mutation_p.P189S|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Missense_Mutation_p.P189S|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Missense_Mutation_p.P189S|ADARB1_uc010gpx.2_Intron|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA|ADARB1_uc011afo.1_Missense_Mutation_p.P238S	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	189					adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		GGCGGAGCCTCCCTTTTACGT	0.592													12	20					0	0	0.001368	0	0
COL6A1	1291	broad.mit.edu	37	21	47419593	47419593	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:47419593C>T	uc002zhu.1	+	27	1865	c.1763C>T	c.(1762-1764)CCG>CTG	p.P588L	COL6A1_uc010gqd.1_5'UTR|COL6A1_uc002zhv.1_5'Flank|COL6A1_uc002zhw.1_5'Flank	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	588	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CACCAAGGACCGCCTGGGCCG	0.637													6	14					0	0	0.003080	0	0
COL6A2	1292	broad.mit.edu	37	21	47551942	47551942	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:47551942G>A	uc002zia.1	+	28	2618	c.2536G>A	c.(2536-2538)GAG>AAG	p.E846K	COL6A2_uc002zib.1_Missense_Mutation_p.E252K|COL6A2_uc002zic.1_5'UTR|COL6A2_uc010gqe.1_RNA	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	846	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GCGGCTGGGTGAGCAGAACTT	0.706													6	5					0	0	0.001168	0	0
PCNT	5116	broad.mit.edu	37	21	47831715	47831715	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:47831715C>T	uc002zji.3	+	28	5835	c.5728C>T	c.(5728-5730)CTG>TTG	p.L1910L	PCNT_uc002zjj.2_Silent_p.L1792L	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1910	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCAGCAGCCCCTGGCAGCCGG	0.726													3	3					0	0	0.000248	0	0
PCNT	5116	broad.mit.edu	37	21	47864622	47864622	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:47864622A>G	uc002zji.3	+	46	9962	c.9855A>G	c.(9853-9855)CCA>CCG	p.P3285P	PCNT_uc002zjj.2_Silent_p.P3088P	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	3285					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CTCCATCCCCAAATTCAAGAT	0.403													16	26					0	0	0.004990	0	0
POTEH	23784	broad.mit.edu	37	22	16267070	16267071	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:16267070_16267071CC>TT	uc010gqp.2	-	9	1430_1431	c.1378_1379GG>AA	c.(1378-1380)GGA>AAA	p.G460K	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.G179K|POTEH_uc002zlj.1_Missense_Mutation_p.G295K	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	460										skin(1)	1						ATGAGTACTTCCGTGCTTCTTC	0.361													26	225					0	0	0.004672	0	0
POTEH	23784	broad.mit.edu	37	22	16287309	16287309	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:16287309C>T	uc010gqp.2	-	1	629	c.577G>A	c.(577-579)GAT>AAT	p.D193N	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_5'UTR|POTEH_uc002zlj.1_Missense_Mutation_p.D28N	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	193	ANK 1.									skin(1)	1						ACGATGAGATCCTTTCTGGGG	0.552													6	100					0	0	0.004007	0	0
PEX26	55670	broad.mit.edu	37	22	18568002	18568002	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:18568002C>T	uc002znp.3	+	5	1001	c.792C>T	c.(790-792)CTC>CTT	p.L264L	TUBA8_uc002znr.2_Intron|PEX26_uc002znq.3_Silent_p.L264L|PEX26_uc002znt.2_Intron	NM_017929	NP_060399	Q7Z412	PEX26_HUMAN	peroxisome biogenesis factor 26	264	Helical; Signal-anchor for type II membrane protein; (Potential).				protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			skin(1)	1						TCCTCTGTCTCCTGGTGGTGA	0.562													38	128					0	0	0.006999	0	0
HIRA	7290	broad.mit.edu	37	22	19384456	19384456	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:19384456G>A	uc002zpf.1	-	7	728	c.508C>T	c.(508-510)CTG>TTG	p.L170L	HIRA_uc011agx.1_Silent_p.L36L|HIRA_uc010grn.1_Silent_p.L170L|HIRA_uc010gro.1_Silent_p.L126L|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	170					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					TGACCTCTCAGAGTAGCTAGA	0.478													17	77					0	0	0.007413	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20130629	20130629	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:20130629C>T	uc002zrq.2	+	10	1582	c.1476C>T	c.(1474-1476)GCC>GCT	p.A492A	ZDHHC8_uc002zrr.1_Silent_p.A492A|ZDHHC8_uc010gsa.2_Silent_p.A298A	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	492	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					GTGGCCACGCCTGCCCTGCCC	0.677													17	25					0	0	0.007413	0	0
ZNF74	7625	broad.mit.edu	37	22	20760971	20760971	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:20760971C>T	uc010gsm.2	+	6	1860	c.1648C>T	c.(1648-1650)CAC>TAC	p.H550Y	ZNF74_uc002zsg.2_Missense_Mutation_p.H479Y|ZNF74_uc002zsh.2_Missense_Mutation_p.H550Y|ZNF74_uc002zsi.2_Missense_Mutation_p.H479Y|ZNF74_uc010gsn.2_Missense_Mutation_p.H479Y	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	550	C2H2-type 11.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TCAGAAAATCCACTCCGGGGA	0.562													18	67					0	0	0.007413	0	0
KLHL22	84861	broad.mit.edu	37	22	20812259	20812259	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:20812259G>A	uc002zsl.1	-	5	1250	c.1141C>T	c.(1141-1143)CAG>TAG	p.Q381*	KLHL22_uc011ahr.1_Nonsense_Mutation_p.Q238*|KLHL22_uc002zsm.1_Nonsense_Mutation_p.Q381*	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	381	Kelch 2.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GACTGGATCTGGAACCAGCGG	0.597													10	26					0	0	0.000978	0	0
CCDC116	164592	broad.mit.edu	37	22	21988757	21988757	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:21988757C>G	uc002zve.2	+	3	612	c.519C>G	c.(517-519)AGC>AGG	p.S173R	CCDC116_uc011aih.1_Missense_Mutation_p.S173R	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	173										ovary(1)|skin(1)	2	Colorectal(54;0.105)					GCTCCCACAGCCGGGACAGTG	0.607													17	45					0	0	0.007413	0	0
TOP3B	8940	broad.mit.edu	37	22	22312879	22312879	+	Nonsense_Mutation	SNP	G	A	A	rs142196057		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:22312879G>A	uc002zvs.2	-	17	2527	c.2092C>T	c.(2092-2094)CGA>TGA	p.R698*	TOP3B_uc010gtm.1_Nonsense_Mutation_p.R243*|TOP3B_uc002zvr.2_Nonsense_Mutation_p.R423*|TOP3B_uc010gtl.2_Nonsense_Mutation_p.R698*|TOP3B_uc002zvt.3_Nonsense_Mutation_p.R698*	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	698					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TTCATGTCTCGGAAGGGTGGG	0.602													25	144					0	0	0.004656	0	0
LOC96610	96610	broad.mit.edu	37	22	23165548	23165548	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:23165548C>T	uc011aim.1	+	287		c.13110C>T								Parts of antibodies, mostly variable regions.												0						GTCACCATCTCCTGCACTGGA	0.557													73	277					0	0	0.003610	0	0
GGT5	2687	broad.mit.edu	37	22	24622695	24622695	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:24622695C>T	uc002zzo.3	-	7	1359	c.942G>A	c.(940-942)GGG>GGA	p.G314G	GGT5_uc002zzp.3_Silent_p.G314G|GGT5_uc002zzr.3_Silent_p.G282G|GGT5_uc002zzq.3_Silent_p.G282G|GGT5_uc011ajm.1_Silent_p.G237G|GGT5_uc011ajn.1_RNA	NM_004121	NP_004112	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5 isoform b	314	Extracellular (Potential).				glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(2)|skin(1)	3						CGTTCACCCTCCCTTCAGGCC	0.572													36	67					0	0	0.006999	0	0
POM121L9P	29774	broad.mit.edu	37	22	24658524	24658524	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:24658524C>T	uc002zzs.3	+	6		c.3148C>T			uc011ajp.1_5'Flank	NR_003714				Homo sapiens mRNA; cDNA DKFZp434P211 (from clone DKFZp434P211).												0						CCGACATGTCCTTCTTATCTG	0.562													12	28					0	0	0.003163	0	0
CYTSA	23384	broad.mit.edu	37	22	24720332	24720332	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:24720332G>A	uc002zzw.2	+	6	2390	c.2083G>A	c.(2083-2085)GAT>AAT	p.D695N	CYTSA_uc002zzv.3_Missense_Mutation_p.D695N|CYTSA_uc011ajq.1_Missense_Mutation_p.D695N	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	695	Potential.				cell cycle|cell division						0						TGAACTTGAAGATGAAGTAGA	0.328													33	27					0	0	0.003755	0	0
MYO18B	84700	broad.mit.edu	37	22	26224752	26224752	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:26224752C>T	uc003abz.1	+	15	3046	c.2796C>T	c.(2794-2796)TCC>TCT	p.S932S	MYO18B_uc003aca.1_Silent_p.S813S|MYO18B_uc010guy.1_Silent_p.S813S|MYO18B_uc010guz.1_Silent_p.S813S|MYO18B_uc011aka.1_Silent_p.S86S|MYO18B_uc011akb.1_Silent_p.S445S	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	932	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GATCCTTTTCCTCCCACCATC	0.468													17	18					0	0	0.007413	0	0
MYO18B	84700	broad.mit.edu	37	22	26228894	26228894	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:26228894C>T	uc003abz.1	+	16	3240	c.2990C>T	c.(2989-2991)CCT>CTT	p.P997L	MYO18B_uc003aca.1_Missense_Mutation_p.P878L|MYO18B_uc010guy.1_Missense_Mutation_p.P878L|MYO18B_uc010guz.1_Missense_Mutation_p.P878L|MYO18B_uc011aka.1_Missense_Mutation_p.P151L|MYO18B_uc011akb.1_Missense_Mutation_p.P510L	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	997	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GAAGGTGTTCCTGTGCAGTTT	0.507													32	32					0	0	0.005524	0	0
MYO18B	84700	broad.mit.edu	37	22	26242163	26242163	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:26242163G>A	uc003abz.1	+	19	3715	c.3465G>A	c.(3463-3465)CAG>CAA	p.Q1155Q	MYO18B_uc003aca.1_Silent_p.Q1036Q|MYO18B_uc010guy.1_Silent_p.Q1037Q|MYO18B_uc010guz.1_Silent_p.Q1036Q|MYO18B_uc011aka.1_Silent_p.Q309Q|MYO18B_uc011akb.1_Silent_p.Q668Q	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1155	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AGGCCCTGCAGAGGAGCCGCA	0.672													7	12					0	0	0.001984	0	0
MYO18B	84700	broad.mit.edu	37	22	26242247	26242247	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:26242247G>A	uc003abz.1	+	19	3799	c.3549G>A	c.(3547-3549)CAG>CAA	p.Q1183Q	MYO18B_uc003aca.1_Silent_p.Q1064Q|MYO18B_uc010guy.1_Silent_p.Q1065Q|MYO18B_uc010guz.1_Silent_p.Q1064Q|MYO18B_uc011aka.1_Silent_p.Q337Q|MYO18B_uc011akb.1_Silent_p.Q696Q	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1183	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TCAAGCTGCAGATGGTGAGTG	0.512													17	28					0	0	0.001523	0	0
MYO18B	84700	broad.mit.edu	37	22	26423583	26423583	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:26423583C>A	uc003abz.1	+	43	7893	c.7643C>A	c.(7642-7644)CCA>CAA	p.P2548Q	MYO18B_uc003aca.1_Missense_Mutation_p.P2429Q|MYO18B_uc010guy.1_Missense_Mutation_p.P2430Q|MYO18B_uc010guz.1_Missense_Mutation_p.P2428Q|MYO18B_uc011aka.1_Missense_Mutation_p.P1702Q|MYO18B_uc011akb.1_Missense_Mutation_p.P2061Q|MYO18B_uc010gva.1_Missense_Mutation_p.P531Q|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2548						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CGGAGAGAGCCAGGGACGGGG	0.542													10	2					0.000442599	0.000669083	0.006214	1	0
CRYBA4	1413	broad.mit.edu	37	22	27024309	27024309	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:27024309G>A	uc003acz.3	+	5	393	c.358G>A	c.(358-360)GGA>AGA	p.G120R		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	120	Beta/gamma crystallin 'Greek key' 3.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						GGGCAAGAAAGGAGAGCTGAG	0.542													24	37					0	0	0.003954	0	0
CRYBA4	1413	broad.mit.edu	37	22	27026391	27026391	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:27026391G>A	uc003acz.3	+	6	566	c.531G>A	c.(529-531)CGG>CGA	p.R177R		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	177	Beta/gamma crystallin 'Greek key' 4.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						AACATTTCCGGGAGTGGGGCT	0.572													11	21					0	0	0.000978	0	0
RHBDD3	25807	broad.mit.edu	37	22	29656198	29656198	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:29656198G>A	uc003aeq.1	-	7	1384	c.1012C>T	c.(1012-1014)CCT>TCT	p.P338S	RHBDD3_uc003aer.1_RNA	NM_012265	NP_036397	Q9Y3P4	RHBD3_HUMAN	rhomboid domain containing 3	338	UBA.					integral to membrane	serine-type endopeptidase activity			ovary(1)	1						TGCTCCGTAGGGAAGCCCATG	0.672													4	7					0	0	0.000602	0	0
GAS2L1	10634	broad.mit.edu	37	22	29708302	29708302	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:29708302C>T	uc003afa.1	+	7	2061	c.1862C>T	c.(1861-1863)CCC>CTC	p.P621L	GAS2L1_uc010gvm.1_Missense_Mutation_p.P394L|GAS2L1_uc003afb.1_3'UTR|GAS2L1_uc003afc.1_Missense_Mutation_p.P621L|GAS2L1_uc003afd.1_3'UTR|GAS2L1_uc003afe.1_3'UTR	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	621					cell cycle arrest	cytoplasm|cytoskeleton					0						CCTGGGAGCCCCCTGGCTTGC	0.682													25	18					0	0	0.004656	0	0
CCDC157	550631	broad.mit.edu	37	22	30766447	30766447	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:30766447C>T	uc011aku.1	+	5	1213	c.553C>T	c.(553-555)CAA>TAA	p.Q185*	CCDC157_uc011akv.1_Nonsense_Mutation_p.Q185*	NM_001017437	NP_001017437	Q569K6	CC157_HUMAN	coiled-coil domain containing 157	185										central_nervous_system(1)	1						CCAGACCTGCCAAGAGCCAGA	0.597													30	8					0	0	0.001786	0	0
LIMK2	3985	broad.mit.edu	37	22	31662023	31662023	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:31662023C>T	uc003akh.2	+	8	1091	c.946C>T	c.(946-948)CGT>TGT	p.R316C	LIMK2_uc003akg.2_Missense_Mutation_p.R233C|LIMK2_uc003aki.2_Missense_Mutation_p.R70C|LIMK2_uc003akj.2_Missense_Mutation_p.R295C|LIMK2_uc003akk.2_Missense_Mutation_p.R295C|LIMK2_uc011aln.1_Missense_Mutation_p.R233C	NM_005569	NP_005560	P53671	LIMK2_HUMAN	LIM domain kinase 2 isoform 2a	316						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2						AGAATCCCTTCGTTGTTCCAG	0.577													34	35					0	0	0.004289	0	0
DEPDC5	9681	broad.mit.edu	37	22	32211046	32211046	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:32211046C>T	uc003als.2	+	21	1656	c.1514C>T	c.(1513-1515)TCC>TTC	p.S505F	DEPDC5_uc011als.1_Missense_Mutation_p.S505F|DEPDC5_uc011alu.1_Missense_Mutation_p.S505F|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.S505F|DEPDC5_uc003alr.1_Missense_Mutation_p.S505F|DEPDC5_uc011alt.1_Missense_Mutation_p.S477F	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	505					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						TCCAGCCCTTCCCTACCAAGC	0.552													18	56					0	0	0.007413	0	0
BPIL2	254240	broad.mit.edu	37	22	32853350	32853350	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:32853350G>A	uc003amn.2	-	1	24	c.24C>T	c.(22-24)GTC>GTT	p.V8V	BPIL2_uc010gwo.2_5'UTR|BPIL2_uc011amb.1_5'UTR|BPIL2_uc003amo.3_Silent_p.V8V	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	8						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						ATCCCCAGAGGACTGGGATTG	0.403											OREG0003513	type=REGULATORY REGION|Gene=BPIL2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	25	38					0	0	0.004656	0	0
LARGE	9215	broad.mit.edu	37	22	33673211	33673211	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:33673211G>A	uc003and.3	-	15	2487	c.1908C>T	c.(1906-1908)CCC>CCT	p.P636P	LARGE_uc011amd.1_Silent_p.P435P|LARGE_uc003ane.3_Silent_p.P636P|LARGE_uc010gwp.2_Silent_p.P584P|LARGE_uc011ame.1_Silent_p.P568P|LARGE_uc011amf.1_Silent_p.P587P	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	636	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				CGAAGTTTGTGGGTGCGTGGC	0.582													9	75					0	0	0.006214	0	0
HMGXB4	10042	broad.mit.edu	37	22	35661516	35661516	+	Missense_Mutation	SNP	C	T	T	rs28522155		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:35661516C>T	uc003anl.2	+	5	1309	c.1135C>T	c.(1135-1137)CCT>TCT	p.P379S	HMGXB4_uc011amh.1_Missense_Mutation_p.P270S|HMGXB4_uc003ank.2_Missense_Mutation_p.P270S	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	379					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						CCTGCCACTTCCTGGCCTCCA	0.413													15	40					0	0	0.003163	0	0
RASD2	23551	broad.mit.edu	37	22	35947656	35947656	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:35947656G>A	uc003anx.2	+	3	583	c.378G>A	c.(376-378)AAG>AAA	p.K126K	RASD2_uc003any.2_Silent_p.K126K	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	126					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						TGAAGAACAAGACCAAGGAGG	0.607													18	129					0	0	0.006122	0	0
TRIOBP	11078	broad.mit.edu	37	22	38131177	38131177	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:38131177G>A	uc003atr.2	+	9	5105	c.4834G>A	c.(4834-4836)GAG>AAG	p.E1612K	TRIOBP_uc003atu.2_Missense_Mutation_p.E1440K	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	1612					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TTTAGGGCCAGAGCTGGGTCC	0.672											OREG0026548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	83	13					0	0	0.003610	0	0
TRIOBP	11078	broad.mit.edu	37	22	38150944	38150944	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:38150944C>T	uc003atr.2	+	13	5711	c.5440C>T	c.(5440-5442)CTG>TTG	p.L1814L	TRIOBP_uc003atu.2_Silent_p.L1642L|TRIOBP_uc003atv.2_Silent_p.L101L|TRIOBP_uc003atw.2_Silent_p.L101L|TRIOBP_uc003atx.1_5'Flank|TRIOBP_uc010gxh.2_5'Flank	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	1814	PH.				actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TTGGTTTGTGCTGACAGATTC	0.547													11	98					0	0	0.001368	0	0
ENTHD1	150350	broad.mit.edu	37	22	40161379	40161379	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:40161379G>A	uc003ayg.2	-	6	1319	c.1068C>T	c.(1066-1068)TTC>TTT	p.F356F		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	356										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					CCTGGTTATGGAAAGTAGAAT	0.413													34	36					0	0	0.004289	0	0
GRAP2	9402	broad.mit.edu	37	22	40365475	40365475	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:40365475G>C	uc003ayh.1	+	7	1014	c.751G>C	c.(751-753)GAA>CAA	p.E251Q	GRAP2_uc003ayi.2_RNA|GRAP2_uc011aom.1_Missense_Mutation_p.E225Q|GRAP2_uc011aon.1_Missense_Mutation_p.E185Q|GRAP2_uc010gya.1_Missense_Mutation_p.E251Q|GRAP2_uc011aoo.1_Missense_Mutation_p.E179Q|GRAP2_uc011aop.1_Missense_Mutation_p.E211Q|GRAP2_uc011aoq.1_Missense_Mutation_p.E138Q|GRAP2_uc003ayj.1_Missense_Mutation_p.E251Q	NM_004810	NP_004801	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	251					cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						CTTGGGCAGTGAAATGAATGC	0.572													24	65					0	0	0.004656	0	0
TNRC6B	23112	broad.mit.edu	37	22	40718959	40718959	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:40718959C>T	uc011aor.1	+	23	5427	c.5216C>T	c.(5215-5217)CCA>CTA	p.P1739L	TNRC6B_uc003aym.2_Missense_Mutation_p.P935L|TNRC6B_uc003ayn.3_Missense_Mutation_p.P1629L	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	1739					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						GCAGCAACCCCAAGTGCGCCA	0.587													4	9					0	0	0.000248	0	0
EP300	2033	broad.mit.edu	37	22	41573345	41573345	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:41573345C>T	uc003azl.3	+	31	6025	c.5630C>T	c.(5629-5631)CCT>CTT	p.P1877L		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1877					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CAGCCTCAGCCTACCCCTCCC	0.647			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				15	125					0	0	0.004007	0	0
RANGAP1	5905	broad.mit.edu	37	22	41648895	41648895	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:41648895G>A	uc003azs.2	-	11	2831	c.1361C>T	c.(1360-1362)TCC>TTC	p.S454F	RANGAP1_uc003azt.2_Missense_Mutation_p.S454F|RANGAP1_uc003azu.2_Missense_Mutation_p.S454F|RANGAP1_uc003azr.2_5'UTR|RANGAP1_uc010gyk.2_5'UTR|RANGAP1_uc011aoz.1_Missense_Mutation_p.S399F	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	454					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						TATCAGCACGGAGCTCTTGGG	0.607													19	50					0	0	0.008871	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41721580	41721580	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:41721580C>T	uc003azw.2	+	3	282	c.66C>T	c.(64-66)CCC>CCT	p.P22P	ZC3H7B_uc003azv.1_Silent_p.P22P|ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	22					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						CGACACTACCCCTAAAGCAAG	0.587													4	36					0	0	0.000248	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41735933	41735933	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:41735933C>T	uc003azw.2	+	10	1146	c.930C>T	c.(928-930)ATC>ATT	p.I310I	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	326					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						GTGGCTCCATCCCTGTCTCCA	0.687													17	51					0	0	0.004990	0	0
MEI1	150365	broad.mit.edu	37	22	42166716	42166716	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:42166716C>T	uc003baz.1	+	20	2320	c.2295C>T	c.(2293-2295)TTC>TTT	p.F765F	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Silent_p.F151F|MEI1_uc003bbc.1_Silent_p.F133F|MEI1_uc010gym.1_Silent_p.F133F|MEI1_uc003bbd.1_Silent_p.F8F	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	765							binding			central_nervous_system(1)|skin(1)	2						TCAGAAAATTCCTAGAAGGCA	0.488													4	23					0	0	0.000248	0	0
EFCAB6	64800	broad.mit.edu	37	22	44168800	44168800	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:44168800C>T	uc003bdy.1	-	4	538	c.323G>A	c.(322-324)CGA>CAA	p.R108Q	EFCAB6_uc003bdz.1_Intron|EFCAB6_uc010gzi.1_Intron|EFCAB6_uc011aqa.1_Intron|EFCAB6_uc003bea.1_Missense_Mutation_p.R105Q|EFCAB6_uc003beb.3_Intron	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				AAACTGTTCTCGTGTGAGCGG	0.463													21	20					0	0	0.002299	0	0
WNT7B	7477	broad.mit.edu	37	22	46318890	46318890	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:46318890G>A	uc003bgo.2	-	4	1270	c.896C>T	c.(895-897)CCC>CTC	p.P299L	WNT7B_uc010haa.2_Missense_Mutation_p.P303L	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	299					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		GTCCGCGCCGGGCGACGTGCG	0.642													22	10					0	0	0.002780	0	0
BRD1	23774	broad.mit.edu	37	22	50216722	50216722	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:50216722C>T	uc003biv.2	-	1	1731	c.1244G>A	c.(1243-1245)AGC>AAC	p.S415N	BRD1_uc011arf.1_5'UTR|BRD1_uc011arg.1_Missense_Mutation_p.S415N|BRD1_uc011arh.1_Missense_Mutation_p.S415N|BRD1_uc003biu.3_Missense_Mutation_p.S415N	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	415					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TTTAACCGAGCTCTCTTTTCG	0.547													60	213					0	0	0.003610	0	0
TTLL8	164714	broad.mit.edu	37	22	50470225	50470225	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:50470225G>A	uc011ark.1	-	11	1597	c.1597C>T	c.(1597-1599)CCG>TCG	p.P533S		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		GGCGTGGACGGGTGCATGGTG	0.622													10	79					0	0	0.008291	0	0
MOV10L1	54456	broad.mit.edu	37	22	50580509	50580509	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:50580509G>A	uc003bjj.2	+	16	2154	c.2071_splice	c.e16-1	p.N691_splice	MOV10L1_uc003bjk.3_Splice_Site_p.N691_splice|MOV10L1_uc011arp.1_Splice_Site_p.N671_splice|MOV10L1_uc011arq.1_Splice_Site_p.N452_splice|MOV10L1_uc010hao.1_Splice_Site	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1						germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		ATAATTTCTAGAATAGGAAAA	0.428													86	62					0	0	0.003610	0	0
MOV10L1	54456	broad.mit.edu	37	22	50580554	50580554	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:50580554G>A	uc003bjj.2	+	16	2198	c.2115G>A	c.(2113-2115)GAG>GAA	p.E705E	MOV10L1_uc003bjk.3_Silent_p.E705E|MOV10L1_uc011arp.1_Silent_p.E685E|MOV10L1_uc011arq.1_Silent_p.E466E|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	705					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GAACAGAGGAGAGGCGTGTTG	0.478													90	70					0	0	0.003610	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987593	50987593	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:50987593G>A	uc003bmi.2	+	1	1132	c.998G>A	c.(997-999)CGG>CAG	p.R333Q		NM_138433	NP_612442	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	333	Kelch 1.									central_nervous_system(1)	1		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AACACCTGGCGGCCCCTGACC	0.706													18	58					0	0	0.006122	0	0
CHL1	10752	broad.mit.edu	37	3	361522	361522	+	Silent	SNP	C	T	T	rs142096855		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:361522C>T	uc003bou.2	+	3	334	c.63C>T	c.(61-63)TTC>TTT	p.F21F	CHL1_uc003bot.2_Silent_p.F21F|CHL1_uc003bow.1_Silent_p.F21F|CHL1_uc011asi.1_Silent_p.F21F	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	21					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TGTTAAAATTCTCAAAAGCAA	0.328													16	32					0	0	0.007413	0	0
CNTN4	152330	broad.mit.edu	37	3	2861197	2861197	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:2861197G>A	uc003bpc.2	+	6	607	c.386G>A	c.(385-387)AGA>AAA	p.R129K	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Missense_Mutation_p.R129K	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	129	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ACAAGAACAAGAAGCACTGTG	0.413													15	44					0	0	0.004990	0	0
LRRN1	57633	broad.mit.edu	37	3	3887884	3887884	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:3887884T>C	uc003bpt.3	+	2	2320	c.1559T>C	c.(1558-1560)CTT>CCT	p.L520P	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	520	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		AATGGGACCCTTCTGGATGGT	0.438													22	61					0	0	0.002780	0	0
ITPR1	3708	broad.mit.edu	37	3	4735338	4735338	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:4735338G>A	uc003bqa.2	+	33	4515	c.4167G>A	c.(4165-4167)AAG>AAA	p.K1389K	ITPR1_uc010hca.1_Silent_p.K1374K|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Silent_p.K320K	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	1398	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CGGAGGGTAAGAATGTCTACA	0.572													19	32					0	0	0.006122	0	0
GRM7	2917	broad.mit.edu	37	3	7456764	7456764	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:7456764G>A	uc003bqm.2	+	5	1362	c.1088G>A	c.(1087-1089)TGG>TAG	p.W363*	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Nonsense_Mutation_p.W363*|GRM7_uc003bql.2_Nonsense_Mutation_p.W363*|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	363	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	AGAAATGTATGGTTTGCCGAA	0.413													11	23					0	0	0.001368	0	0
CPNE9	151835	broad.mit.edu	37	3	9771272	9771272	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:9771272G>A	uc003bsd.2	+	20	1729	c.1558G>A	c.(1558-1560)GAG>AAG	p.E520K	BRPF1_uc003bse.2_5'Flank|BRPF1_uc003bsf.2_5'Flank|BRPF1_uc003bsg.2_5'Flank|BRPF1_uc011ati.1_5'Flank	NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	520										ovary(2)	2	Medulloblastoma(99;0.227)					TGTGCTGGCCGAGATCCCGGA	0.637													23	42					0	0	0.003954	0	0
OGG1	4968	broad.mit.edu	37	3	9793459	9793459	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:9793459C>G	uc003bsi.2	+	3	734	c.391C>G	c.(391-393)CGA>GGA	p.R131G	OGG1_uc003bsh.2_Missense_Mutation_p.R131G|OGG1_uc003bsj.2_Missense_Mutation_p.R131G|OGG1_uc003bsk.2_Missense_Mutation_p.R131G|OGG1_uc003bsl.2_Missense_Mutation_p.R131G|OGG1_uc003bsm.2_Missense_Mutation_p.R131G|OGG1_uc003bsn.2_Missense_Mutation_p.R131G|OGG1_uc003bso.2_Missense_Mutation_p.R131G|OGG1_uc003bsp.1_5'UTR|OGG1_uc010hcm.1_5'UTR|OGG1_uc003bsq.1_5'UTR|OGG1_uc003bsr.1_5'UTR	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	131			R -> Q (found in a lung cancer sample; loss of activity).		depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)					TCCAGGTGTGCGACTGCTGCG	0.557								BER_DNA_glycosylases					41	110					0	0	0.002852	0	0
Unknown	0	broad.mit.edu	37	3	12299838	12299838	+	RNA	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:12299838G>A	uc003bwp.1	-	1		c.115C>T				NR_003112				NR_003112																		GTCATAGTCAGGAGAGTCCCC	0.507													15	43					0	0	0.004007	0	0
C3orf20	84077	broad.mit.edu	37	3	14744762	14744762	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:14744762C>T	uc003byy.2	+	6	1275	c.871C>T	c.(871-873)CGC>TGC	p.R291C	C3orf20_uc003byz.2_Missense_Mutation_p.R169C|C3orf20_uc003bza.2_Missense_Mutation_p.R169C|C3orf20_uc003byx.1_Missense_Mutation_p.R291C	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	291						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						GGAGTTGTGTCGCCACATGTG	0.627													36	66					0	0	0.005524	0	0
C3orf20	84077	broad.mit.edu	37	3	14745926	14745926	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:14745926C>T	uc003byy.2	+	7	1365	c.961C>T	c.(961-963)CAT>TAT	p.H321Y	C3orf20_uc003byz.2_Missense_Mutation_p.H199Y|C3orf20_uc003bza.2_Missense_Mutation_p.H199Y|C3orf20_uc003byx.1_Intron	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	321						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						GATGCCCTCTCATCTAATGTT	0.527													36	84					0	0	0.004289	0	0
FGD5	152273	broad.mit.edu	37	3	14949198	14949198	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:14949198G>A	uc003bzc.2	+	10	3426	c.3316G>A	c.(3316-3318)GAT>AAT	p.D1106N	FGD5_uc011avk.1_Missense_Mutation_p.D1106N|FGD5_uc003bzd.2_Missense_Mutation_p.D184N	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1106					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						GGGCCAAGGGGATCTCCTCCA	0.647													14	33					0	0	0.004007	0	0
FGD5	152273	broad.mit.edu	37	3	14964650	14964650	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:14964650A>C	uc003bzc.2	+	16	4015	c.3905A>C	c.(3904-3906)AAG>ACG	p.K1302T	FGD5_uc011avk.1_Missense_Mutation_p.K1302T|FGD5_uc003bzd.2_Missense_Mutation_p.K380T	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1302					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						GAGCTGAAGAAGCGGGGCAGG	0.617													9	22					0	0	0.006214	0	0
GALNTL2	117248	broad.mit.edu	37	3	16252704	16252704	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:16252704C>T	uc003car.3	+	5	1628	c.1153C>T	c.(1153-1155)CTT>TTT	p.L385F	GALNTL2_uc003caq.3_Missense_Mutation_p.L118F	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	385	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						GTATGACTCTCTTATGTCGCT	0.542													21	61					0	0	0.002780	0	0
EFHB	151651	broad.mit.edu	37	3	19956846	19956846	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:19956846C>T	uc003cbl.3	-	5	1433	c.1237G>A	c.(1237-1239)GGA>AGA	p.G413R	EFHB_uc003cbm.2_Missense_Mutation_p.G283R	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	413					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						CCTTCATTTCCTTCTTTAAAT	0.368													22	52					0	0	0.003330	0	0
GLB1	2720	broad.mit.edu	37	3	33038604	33038605	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:33038604_33038605GG>AA	uc003cfi.1	-	16	2083_2084	c.1966_1967CC>TT	c.(1966-1968)CCT>TTT	p.P656F	GLB1_uc003cfh.1_Missense_Mutation_p.P626F|GLB1_uc003cfj.1_Missense_Mutation_p.P525F|GLB1_uc011axk.1_Missense_Mutation_p.P704F	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	656					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				TTTTTCAACAGGTTTGGAGGGA	0.495													29	67					0	0	0.004672	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33893999	33893999	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:33893999C>T	uc003cfx.2	+	13	1816	c.1661C>T	c.(1660-1662)TCC>TTC	p.S554F	PDCD6IP_uc003cfy.2_Missense_Mutation_p.S559F|PDCD6IP_uc011axw.1_Missense_Mutation_p.S335F	NM_013374	NP_037506	Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	554	Interaction with EIAV p9.|Self-association.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2						GTCTTAAAATCCTTATTGTCA	0.303													7	25					0	0	0.008291	0	0
TRANK1	9881	broad.mit.edu	37	3	36874255	36874255	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:36874255G>A	uc003cgj.2	-	12	5339	c.5037C>T	c.(5035-5037)TTC>TTT	p.F1679F		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2229					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						AATGCTTAGGGAAAAGGACAT	0.368													36	72					0	0	0.004289	0	0
TRANK1	9881	broad.mit.edu	37	3	36899148	36899148	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:36899148G>A	uc003cgj.2	-	3	585	c.283C>T	c.(283-285)CCA>TCA	p.P95S		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	645					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GCACCACATGGCACTGACTTG	0.602													27	79					0	0	0.007291	0	0
SLC22A14	9389	broad.mit.edu	37	3	38347571	38347571	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38347571G>A	uc010hhc.1	+	2	96	c.54G>A	c.(52-54)AGG>AGA	p.R18R	SLC22A14_uc003cia.2_Silent_p.R18R|SLC22A14_uc003cib.2_Silent_p.R18R|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	18	Cytoplasmic (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		ATGCTTCCAGGAACTTGAACC	0.522													37	99					0	0	0.005524	0	0
SCN5A	6331	broad.mit.edu	37	3	38622667	38622668	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38622667_38622668GG>AA	uc003cio.2	-	17	3176_3177	c.2982_2983CC>TT	c.(2980-2985)GCCCTT>GCTTTT	p.L995F	SCN5A_uc003cin.2_Missense_Mutation_p.L995F|SCN5A_uc003cil.3_Missense_Mutation_p.L995F|SCN5A_uc010hhi.2_Missense_Mutation_p.L995F|SCN5A_uc010hhk.2_Missense_Mutation_p.L995F|SCN5A_uc011ayr.1_Missense_Mutation_p.L995F|SCN5A_uc010hhj.1_Missense_Mutation_p.L606F	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	995					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGGGCGGCAAGGGCTGCGGGCT	0.683													4	17					0	0	0.004672	0	0
SCN10A	6336	broad.mit.edu	37	3	38765044	38765044	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38765044C>T	uc003ciq.2	-	18	3229	c.3229G>A	c.(3229-3231)GGA>AGA	p.G1077R		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1077					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCGTCCACTCCCTGCAGGGGA	0.517													4	2					0	0	0.000602	0	0
SCN11A	11280	broad.mit.edu	37	3	38888977	38888977	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38888977G>A	uc011ays.1	-	26	4783	c.4584C>T	c.(4582-4584)ATC>ATT	p.I1528I		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1528	IV.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ATATGTCATCGATTCCAGACT	0.443													14	30					0	0	0.004990	0	0
SCN11A	11280	broad.mit.edu	37	3	38889067	38889067	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38889067G>A	uc011ays.1	-	26	4693	c.4494C>T	c.(4492-4494)TTC>TTT	p.F1498F		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1498	IV.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GACCAATGTTGAACAGAGAAG	0.468													18	42					0	0	0.006122	0	0
TTC21A	199223	broad.mit.edu	37	3	39152380	39152380	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:39152380G>A	uc003cjc.2	+	4	484	c.307G>A	c.(307-309)GAA>AAA	p.E103K	TTC21A_uc003cja.2_Missense_Mutation_p.E103K|TTC21A_uc010hho.1_Missense_Mutation_p.E66K|TTC21A_uc003cjb.2_Intron|TTC21A_uc003cje.2_Missense_Mutation_p.E103K|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.E103K	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	103							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CAGCCTGAAGGAAATACGCAA	0.507													17	35					0	0	0.006122	0	0
XIRP1	165904	broad.mit.edu	37	3	39227497	39227497	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:39227497G>A	uc003cjk.1	-	2	3661	c.3440C>T	c.(3439-3441)CCC>CTC	p.P1147L	XIRP1_uc003cji.2_Intron|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1147							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGTCCTCACGGGATGAGCGGT	0.622													23	47					0	0	0.002780	0	0
CCR8	1237	broad.mit.edu	37	3	39374818	39374818	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:39374818G>A	uc010hhr.2	+	2	1134	c.996G>A	c.(994-996)AGG>AGA	p.R332R	CCR8_uc003cjm.2_Silent_p.R249R	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	332	Cytoplasmic (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		AAATGCCTAGGGAGAGCTGTG	0.388													18	61					0	0	0.008871	0	0
MYRIP	25924	broad.mit.edu	37	3	40291796	40291796	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:40291796G>A	uc003cka.2	+	14	2481	c.2346G>A	c.(2344-2346)CGG>CGA	p.R782R	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.R717R|MYRIP_uc010hhw.2_Silent_p.R693R|MYRIP_uc011ayz.1_Silent_p.R595R|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	782	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		CAAGAAGACGGGATCAGAAGC	0.438													25	41					0	0	0.003330	0	0
HHATL	57467	broad.mit.edu	37	3	42738627	42738627	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:42738627G>A	uc003clw.2	-	9	1023	c.876C>T	c.(874-876)GCC>GCT	p.A292A	HHATL_uc003clx.2_Silent_p.A292A	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	292	Helical; (Potential).				negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		GGTTTGAATAGGCTAGGCCAG	0.627													15	29					0	0	0.004990	0	0
CCBP2	1238	broad.mit.edu	37	3	42906718	42906718	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:42906718C>T	uc003cme.2	+	3	903	c.724C>T	c.(724-726)CCC>TCC	p.P242S	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmf.2_Missense_Mutation_p.P242S|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	242	Cytoplasmic (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		GAGGCTGAGGCCCGCAGGCCA	0.537													43	116					0	0	0.003214	0	0
C3orf23	285343	broad.mit.edu	37	3	44434423	44434423	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:44434423C>T	uc010him.2	+	6	894	c.649C>T	c.(649-651)CGT>TGT	p.R217C	C3orf23_uc003cnd.3_Missense_Mutation_p.R217C|C3orf23_uc003cne.3_Missense_Mutation_p.R73C	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	217						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		AGAACTAGATCGTTTAAAAGA	0.323													34	93					0	0	0.002096	0	0
ZNF197	10168	broad.mit.edu	37	3	44683587	44683587	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:44683587A>C	uc003cnm.2	+	6	1171	c.965A>C	c.(964-966)AAG>ACG	p.K322T	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	322					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		GATACAGTGAAGAAAGTTTCC	0.443													15	28					0	0	0.003163	0	0
CDCP1	64866	broad.mit.edu	37	3	45136996	45136996	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:45136996G>A	uc003com.2	-	5	1224	c.1089C>T	c.(1087-1089)CCC>CCT	p.P363P		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	363	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TCTGTTTGACGGGCCGTGGCT	0.498													22	47					0	0	0.001882	0	0
CCR9	10803	broad.mit.edu	37	3	45943326	45943326	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:45943326G>A	uc003coz.1	+	3	1203	c.1046G>A	c.(1045-1047)AGA>AAA	p.R349K	LZTFL1_uc003coy.1_Intron|LZTFL1_uc011bak.1_Intron|CCR9_uc010hiv.1_Missense_Mutation_p.R337K|CCR9_uc003cpa.1_Missense_Mutation_p.R337K	NM_031200	NP_112477	P51686	CCR9_HUMAN	chemokine (C-C motif) receptor 9 isoform A	349	Cytoplasmic (Potential).				cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane				ovary(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00118)|KIRC - Kidney renal clear cell carcinoma(197;0.0182)|Kidney(197;0.0214)		TTTACAAGGAGAGAGGGAAGC	0.512													17	44					0	0	0.007413	0	0
CCR1	1230	broad.mit.edu	37	3	46245783	46245783	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:46245783C>T	uc003cph.1	-	2	93	c.22G>A	c.(22-24)GAG>AAG	p.E8K	CCR3_uc003cpg.1_Intron	NM_001295	NP_001286	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	8	Extracellular (Potential).				cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			skin(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		TCATAGTCCTCTGTGGTGTTT	0.498													8	20					0	0	0.004482	0	0
CCR3	1232	broad.mit.edu	37	3	46307396	46307396	+	Silent	SNP	C	T	T	rs76939117		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:46307396C>T	uc003cpg.1	+	4	1290	c.747C>T	c.(745-747)TTC>TTT	p.F249F	CCR3_uc003cpi.1_Silent_p.F249F|CCR3_uc003cpj.1_Silent_p.F249F|CCR3_uc003cpk.1_Silent_p.F270F|CCR3_uc010hjb.1_Silent_p.F267F|CCR3_uc003cpl.1_Silent_p.F282F	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	249	Helical; Name=6; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CGGTGTTTTTCATTTTCTGGA	0.458													17	60					0	0	0.008871	0	0
ATRIP	84126	broad.mit.edu	37	3	48501578	48501578	+	Silent	SNP	G	A	A	rs139858543	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:48501578G>A	uc003ctf.1	+	8	1157	c.1125G>A	c.(1123-1125)CTG>CTA	p.L375L	ATRIP_uc011bbj.1_Silent_p.L248L|ATRIP_uc003ctg.1_Silent_p.L375L|TREX1_uc010hjy.2_5'UTR	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	375					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCTCAGCCCTGAGAGAAGCAC	0.512								Other_conserved_DNA_damage_response_genes					34	61					0	0	0.003271	0	0
SLC26A6	65010	broad.mit.edu	37	3	48669454	48669454	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:48669454G>A	uc003cuh.2	-	6	709	c.609C>T	c.(607-609)TTC>TTT	p.F203F	CELSR3_uc003cuf.1_Silent_p.F3608F|SLC26A6_uc003cug.2_Silent_p.F182F|SLC26A6_uc010hke.2_Silent_p.F54F|SLC26A6_uc003cuk.2_Intron|SLC26A6_uc003cui.2_Silent_p.F203F|SLC26A6_uc003cuj.2_Silent_p.F203F|SLC26A6_uc011bbp.1_Missense_Mutation_p.R169W	NM_022911	NP_075062	Q9BXS9	S26A6_HUMAN	solute carrier family 26, member 6 isoform 1	203	Helical; (Potential).					integral to membrane|plasma membrane	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		CCACGAAGCCGAAGTGGATCA	0.612													10	57					0	0	0.001368	0	0
CELSR3	1951	broad.mit.edu	37	3	48682556	48682556	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:48682556G>A	uc003cul.2	-	25	8165	c.7884C>T	c.(7882-7884)TAC>TAT	p.Y2628Y	CELSR3_uc003cuf.1_Silent_p.Y2725Y|CELSR3_uc010hkf.2_5'Flank|CELSR3_uc010hkg.2_Silent_p.Y611Y	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2628	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCTGCATGCGGTAGAGGTGCA	0.662													17	25					0	0	0.006122	0	0
QRICH1	54870	broad.mit.edu	37	3	49070589	49070589	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49070589G>A	uc010hkq.2	-	8	2155	c.1859C>T	c.(1858-1860)TCC>TTC	p.S620F	QRICH1_uc003cvu.2_Missense_Mutation_p.S620F|QRICH1_uc003cvv.2_Missense_Mutation_p.S620F	NM_198880	NP_942581	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	620										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CAGCAAGGTGGAGGGGGAGTG	0.517													18	61					0	0	0.001882	0	0
BSN	8927	broad.mit.edu	37	3	49691938	49691938	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49691938G>A	uc003cxe.3	+	5	5063	c.4949G>A	c.(4948-4950)GGG>GAG	p.G1650E		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1650					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TCTGTCCCTGGGACGTCTAGG	0.642													9	17					0	0	0.004482	0	0
BSN	8927	broad.mit.edu	37	3	49698439	49698439	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49698439C>T	uc003cxe.3	+	6	9275	c.9161C>T	c.(9160-9162)CCC>CTC	p.P3054L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3054					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TTCCAGCAGCCCCGCTTCCAG	0.682													10	33					0	0	0.008291	0	0
BSN	8927	broad.mit.edu	37	3	49701892	49701892	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49701892G>A	uc003cxe.3	+	9	11759	c.11645G>A	c.(11644-11646)GGG>GAG	p.G3882E		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3882					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGAACCCCAGGGGCTCCCGCC	0.622													30	74					0	0	0.001786	0	0
IP6K1	9807	broad.mit.edu	37	3	49775748	49775748	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49775748C>G	uc003cxm.1	-	3	646	c.331G>C	c.(331-333)GAG>CAG	p.E111Q	IP6K1_uc003cxn.1_5'UTR|IP6K1_uc011bcv.1_5'UTR|IP6K1_uc003cxo.2_Missense_Mutation_p.E111Q	NM_153273	NP_695005	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1 isoform 1	111					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						CGAGGTTGCTCCCGTTCTGTT	0.547													19	64					0	0	0.007413	0	0
CDHR4	389118	broad.mit.edu	37	3	49836508	49836508	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49836508G>A	uc010hkz.2	-	3	331	c.322C>T	c.(322-324)CAT>TAT	p.H108Y	CDHR4_uc003cxp.2_Missense_Mutation_p.H108Y|CDHR4_uc011bcw.1_Missense_Mutation_p.H108Y	NM_001007540	NP_001007541	A6H8M9	CDHR4_HUMAN	cadherin-like 29 precursor	108	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TCCATCACATGGTTGCCACAT	0.577													3	5					0	0	0.004672	0	0
UBA7	7318	broad.mit.edu	37	3	49851075	49851075	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49851075A>C	uc003cxr.2	-	2	233	c.62T>G	c.(61-63)GTG>GGG	p.V21G		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	21					ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TGAGCCCAGCACATACCTGTG	0.602													8	29					0	0	0.004482	0	0
SEMA3F	6405	broad.mit.edu	37	3	50219719	50219719	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:50219719G>A	uc003cyj.2	+	8	844	c.646G>A	c.(646-648)GAG>AAG	p.E216K	SEMA3F_uc003cyk.2_Missense_Mutation_p.E185K	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	216	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		ACCCACAGATGAGGAGCTCTA	0.567													23	46					0	0	0.001882	0	0
DOCK3	1795	broad.mit.edu	37	3	51297628	51297628	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:51297628C>T	uc011bds.1	+	23	2249	c.2226C>T	c.(2224-2226)ATC>ATT	p.I742I		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	742						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AGTCACGGATCCTGTACTCAC	0.463													13	19					0	0	0.003163	0	0
DOCK3	1795	broad.mit.edu	37	3	51349912	51349912	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:51349912G>A	uc011bds.1	+	30	3122	c.3099G>A	c.(3097-3099)TGG>TGA	p.W1033*		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1033						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCTAGGTGTGGAATTCTTACT	0.378													20	45					0	0	0.001523	0	0
DOCK3	1795	broad.mit.edu	37	3	51395443	51395443	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:51395443G>A	uc011bds.1	+	46	4842	c.4819G>A	c.(4819-4821)GAA>AAA	p.E1607K		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1607	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGTGCACCCAGAAATGCGGCC	0.507													25	102					0	0	0.005443	0	0
DNAH1	25981	broad.mit.edu	37	3	52384571	52384572	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:52384571_52384572CC>TT	uc011bef.1	+	16	2955_2956	c.2694_2695CC>TT	c.(2692-2697)TTCCTC>TTTTTC	p.L899F	DNAH1_uc003ddt.1_Missense_Mutation_p.L899F	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	899	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGGATGAATTCCTCTACAACCT	0.559													10	15					0	0	0.004672	0	0
DNAH1	25981	broad.mit.edu	37	3	52387454	52387454	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:52387454C>T	uc011bef.1	+	20	3546	c.3285C>T	c.(3283-3285)ATC>ATT	p.I1095I	DNAH1_uc003ddt.1_Silent_p.I1095I	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1095	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AACCATACATCCCACTGATCC	0.602													26	62					0	0	0.006320	0	0
SEMA3G	56920	broad.mit.edu	37	3	52475386	52475386	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:52475386G>A	uc003dea.1	-	7	707	c.707C>T	c.(706-708)TCT>TTT	p.S236F		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	236	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		GTCCTGGTCAGAGTTCTCAGG	0.627													24	36					0	0	0.003954	0	0
SFMBT1	51460	broad.mit.edu	37	3	52955764	52955764	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:52955764G>A	uc003dgf.2	-	12	1784	c.1215C>T	c.(1213-1215)ACC>ACT	p.T405T	SFMBT1_uc010hmr.2_Silent_p.T352T|SFMBT1_uc003dgg.2_Silent_p.T405T|SFMBT1_uc003dgh.2_Silent_p.T405T	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	405	MBT 4.				regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		CTGCAGTGATGGTAGCAACAC	0.488													60	161					0	0	0.003610	0	0
LRTM1	57408	broad.mit.edu	37	3	54958730	54958730	+	Missense_Mutation	SNP	G	A	A	rs142832767		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:54958730G>A	uc003dhl.2	-	2	654	c.520C>T	c.(520-522)CTT>TTT	p.L174F	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	174	Extracellular (Potential).					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		AGAAGTAAAAGCCTCACACTG	0.463													34	63					0	0	0.003755	0	0
CCDC66	285331	broad.mit.edu	37	3	56627978	56627979	+	Missense_Mutation	DNP	CC	TT	TT	rs140193610		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:56627978_56627979CC>TT	uc003dhz.2	+	10	1413_1414	c.1326_1327CC>TT	c.(1324-1329)CTCCGT>CTTTGT	p.R443C	CCDC66_uc003dhy.2_Missense_Mutation_p.R79C|CCDC66_uc003dhu.2_Missense_Mutation_p.R409C|CCDC66_uc003dhx.2_RNA	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	443										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		CCAGCTTTCTCCGTTCTATGAC	0.361													13	45					0	0	0.004672	0	0
IL17RD	54756	broad.mit.edu	37	3	57139951	57139951	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:57139951G>A	uc003dil.2	-	7	770	c.681C>T	c.(679-681)TTC>TTT	p.F227F	IL17RD_uc003dik.2_Silent_p.F203F|IL17RD_uc010hna.2_Silent_p.F83F|IL17RD_uc011bex.1_Silent_p.F83F	NM_017563	NP_060033	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D precursor	227	Extracellular (Potential).					Golgi membrane|integral to membrane|plasma membrane	receptor activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		AGAAGAAACGGAAGCCGAAGT	0.522													12	30					0	0	0.002450	0	0
DNAH12	201625	broad.mit.edu	37	3	57494215	57494215	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:57494215G>A	uc003dit.2	-	7	776	c.595C>T	c.(595-597)CAA>TAA	p.Q199*	DNAH12_uc003diu.2_Nonsense_Mutation_p.Q199*	NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	dynein heavy chain domain 2 isoform 1	199	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			pancreas(1)|skin(1)	2						GAGAATATTTGATTTCTTGCC	0.353													19	32					0	0	0.007413	0	0
FLNB	2317	broad.mit.edu	37	3	58094218	58094218	+	Missense_Mutation	SNP	G	A	A	rs140945224		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:58094218G>A	uc003djj.2	+	13	2140	c.1975G>A	c.(1975-1977)GGA>AGA	p.G659R	FLNB_uc010hne.2_Missense_Mutation_p.G659R|FLNB_uc003djk.2_Missense_Mutation_p.G659R|FLNB_uc010hnf.2_Missense_Mutation_p.G659R|FLNB_uc003djl.2_Missense_Mutation_p.G490R|FLNB_uc003djm.2_Missense_Mutation_p.G490R	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	659	Filamin 5.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGAGAAATCTGGATGCATTGT	0.463													12	30					0	0	0.002450	0	0
DNASE1L3	1776	broad.mit.edu	37	3	58190532	58190533	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:58190532_58190533CC>TT	uc003djo.1	-	4	493_494	c.396_397GG>AA	c.(394-399)AGGGAG>AGAAAG	p.E133K	DNASE1L3_uc011bfd.1_Missense_Mutation_p.E103K|DNASE1L3_uc003djp.1_Missense_Mutation_p.E133K|DNASE1L3_uc003djq.1_Missense_Mutation_p.E133K	NM_004944	NP_004935	Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3 precursor	133					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		ACAAAGGGCTCCCTGGAAAACA	0.525													14	26					0	0	0.004672	0	0
GXYLT2	727936	broad.mit.edu	37	3	73006469	73006469	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:73006469G>A	uc003dpg.2	+	5	942	c.942G>A	c.(940-942)CAG>CAA	p.Q314Q		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	314	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						GGGGAGACCAGGatttattaa	0.443													8	22					0	0	0.004482	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432519	73432519	+	Silent	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:73432519T>A	uc003dpl.1	-	10	3294	c.3198A>T	c.(3196-3198)GTA>GTT	p.V1066V	PDZRN3_uc011bgh.1_Silent_p.V723V|PDZRN3_uc010hoe.1_Silent_p.V764V|PDZRN3_uc011bgf.1_Silent_p.V783V|PDZRN3_uc011bgg.1_Silent_p.V786V	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	1066							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GTGAAAATTATACAGTAGTCA	0.423													30	75					0	0	0.002096	0	0
CNTN3	5067	broad.mit.edu	37	3	74313648	74313648	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:74313648C>T	uc003dpm.1	-	22	3071	c.2991G>A	c.(2989-2991)ATG>ATA	p.M997I		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	997					cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CTCTTGCATCCATACCTGTCA	0.308													14	37					0	0	0.002450	0	0
ROBO2	6092	broad.mit.edu	37	3	77595509	77595509	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:77595509C>T	uc003dpy.3	+	7	1598	c.955C>T	c.(955-957)CGG>TGG	p.R319W	ROBO2_uc003dpz.2_Missense_Mutation_p.R323W|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.R323W	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	319	Ig-like C2-type 4.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GTTTGTGGTTCGGCCAAGAGA	0.393													57	135					0	0	0.003610	0	0
HTR1F	3355	broad.mit.edu	37	3	88040541	88040541	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:88040541G>A	uc003dqr.2	+	2	800	c.642G>A	c.(640-642)AAG>AAA	p.K214K		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	214	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	TATACCACAAGAGACAAGCAA	0.403													16	55					0	0	0.004007	0	0
EPHA3	2042	broad.mit.edu	37	3	89468381	89468381	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:89468381C>T	uc003dqy.2	+	11	2140	c.1915C>T	c.(1915-1917)CGC>TGC	p.R639C	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	639	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTGCAGTGGTCGCTTAAAACT	0.393										TSP Lung(6;0.00050)			24	76					0	0	0.006320	0	0
OR5H2	79310	broad.mit.edu	37	3	98002015	98002015	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:98002015G>A	uc003dsj.1	+	1	284	c.284G>A	c.(283-285)AGG>AAG	p.R95K		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						GCCAAAAACAGGATGATATCT	0.373													49	105					0	0	0.003610	0	0
OR5H2	79310	broad.mit.edu	37	3	98002321	98002321	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:98002321C>T	uc003dsj.1	+	1	590	c.590C>T	c.(589-591)CCT>CTT	p.P197L		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	197	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						TGTACTGACCCTTCTATTAAT	0.308													25	61					0	0	0.003330	0	0
GPR15	2838	broad.mit.edu	37	3	98251703	98251703	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:98251703C>T	uc011bgy.1	+	1	826	c.826C>T	c.(826-828)CCC>TCC	p.P276S		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	276	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		ACACTATTTACCCTCAGCTAT	0.468													23	56					0	0	0.005443	0	0
TOMM70A	9868	broad.mit.edu	37	3	100100601	100100601	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:100100601C>T	uc003dtw.2	-	5	1174	c.742G>A	c.(742-744)GAA>AAA	p.E248K		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	248	Cytoplasmic (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						ATCAGAGGTTCACGATTCTGA	0.373													12	32					0	0	0.001368	0	0
IMPG2	50939	broad.mit.edu	37	3	100964675	100964675	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:100964675C>T	uc003duq.1	-	12	1717	c.1514G>A	c.(1513-1515)AGG>AAG	p.R505K	IMPG2_uc011bhe.1_Missense_Mutation_p.R368K	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	505	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TCCAGAAGTCCTTTCCTCAGA	0.463													38	105					0	0	0.003610	0	0
IFT57	55081	broad.mit.edu	37	3	107932859	107932859	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:107932859G>A	uc003dwx.3	-	4	752	c.504C>T	c.(502-504)TAC>TAT	p.Y168Y		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	168					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			CTTCTACTGGGTATATTGGCC	0.308													7	27					0	0	0.006214	0	0
MORC1	27136	broad.mit.edu	37	3	108682428	108682428	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:108682428C>T	uc003dxl.2	-	27	2719	c.2632G>A	c.(2632-2634)GAA>AAA	p.E878K	MORC1_uc011bhn.1_Missense_Mutation_p.E857K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	878					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						ATTTTTTTTTCATATTGGACC	0.279													17	34					0	0	0.008871	0	0
MORC1	27136	broad.mit.edu	37	3	108724109	108724109	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:108724109T>A	uc003dxl.2	-	19	1908	c.1821A>T	c.(1819-1821)GAA>GAT	p.E607D	MORC1_uc011bhn.1_Missense_Mutation_p.E586D	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	607					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						ATGAAAGAGATTCATGCTTCA	0.348													15	40					0	0	0.003163	0	0
MORC1	27136	broad.mit.edu	37	3	108725901	108725901	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:108725901G>A	uc003dxl.2	-	18	1829	c.1742C>T	c.(1741-1743)TCC>TTC	p.S581F	MORC1_uc011bhn.1_Intron	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	581					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TAGGCAGGTGGAAGTGACAGT	0.388													19	41					0	0	0.001882	0	0
PHLDB2	90102	broad.mit.edu	37	3	111632513	111632513	+	Silent	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:111632513T>G	uc010hqa.2	+	3	2094	c.1683T>G	c.(1681-1683)GCT>GCG	p.A561A	PHLDB2_uc003dyc.2_Silent_p.A588A|PHLDB2_uc003dyd.2_Silent_p.A561A|PHLDB2_uc003dyg.2_Silent_p.A561A|PHLDB2_uc003dyh.2_Silent_p.A561A|PHLDB2_uc003dyi.2_Silent_p.A147A|PHLDB2_uc003dyf.3_Silent_p.A561A	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	561						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TTCCGAAAGCTTCCAGCGAGT	0.507													57	167					0	0	0.003610	0	0
SLC9A10	285335	broad.mit.edu	37	3	111918168	111918168	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:111918168C>T	uc003dyu.2	-	20	2745	c.2523G>A	c.(2521-2523)AAG>AAA	p.K841K	SLC9A10_uc011bhu.1_Silent_p.K104K|SLC9A10_uc010hqc.2_Silent_p.K793K	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	841					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						TTTGCCTTACCTTATTAATTC	0.308													12	68					0	0	0.001855	0	0
SLC9A10	285335	broad.mit.edu	37	3	111997628	111997628	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:111997628A>T	uc003dyu.2	-	4	488	c.266T>A	c.(265-267)TTT>TAT	p.F89Y	SLC9A10_uc011bhu.1_5'UTR|SLC9A10_uc010hqc.2_Missense_Mutation_p.F89Y	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	89	Helical; (Potential).				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						TGCAGTAGTAAAGAAAACTAC	0.318													52	118					0	0	0.003610	0	0
CD200R1L	344807	broad.mit.edu	37	3	112545993	112545993	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:112545993C>A	uc003dzi.1	-	4	752	c.526G>T	c.(526-528)GAG>TAG	p.E176*	CD200R1L_uc011bhw.1_Nonsense_Mutation_p.E155*|CD200R1L_uc010hqf.1_Nonsense_Mutation_p.E155*	NM_001008784	NP_001008784	Q6Q8B3	MO2R2_HUMAN	CD200 cell surface glycoprotein receptor 2	176	Extracellular (Potential).|Ig-like C2-type.					integral to membrane	receptor activity			ovary(1)	1						ATAGATCCCTCTGGGATCCAG	0.507													10	25					7.48243e-07	1.13779e-06	0.006214	1	0
BOC	91653	broad.mit.edu	37	3	113002451	113002451	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:113002451C>T	uc003dzx.2	+	16	3246	c.2625C>T	c.(2623-2625)TTC>TTT	p.F875F	BOC_uc003dzy.2_Silent_p.F875F|BOC_uc003dzz.2_Silent_p.F876F|BOC_uc003eab.2_Silent_p.F576F|BOC_uc003eac.2_Silent_p.F190F	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	875	Helical; (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			TCATCCCCTTCTGCTTGTGGA	0.597													23	51					0	0	0.003330	0	0
DRD3	1814	broad.mit.edu	37	3	113890723	113890723	+	Silent	SNP	G	A	A	rs149122773		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:113890723G>A	uc003ebd.2	-	3	540	c.117C>T	c.(115-117)CTC>CTT	p.L39L	DRD3_uc010hqn.1_Silent_p.L39L|DRD3_uc003ebb.1_Silent_p.L39L|DRD3_uc003ebc.1_Silent_p.L39L	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	39	Helical; Name=1.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding	p.L39L(1)		ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	TGGCCAGGATGAGCGCGCAGT	0.612													15	22					0	0	0.002450	0	0
MIR568	693153	broad.mit.edu	37	3	114035333	114035333	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:114035333C>T	hsa-mir-568|MI0003574	-			c.84C>T			uc003ebh.1_RNA																	0						atatacacacctatacatgta	0.229													5	11					0	0	0.000602	0	0
LSAMP	4045	broad.mit.edu	37	3	115571453	115571453	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:115571453C>T	uc003ebt.2	-	4	1026	c.526G>A	c.(526-528)GAA>AAA	p.E176K	LSAMP_uc011bis.1_Missense_Mutation_p.E176K	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	176	Ig-like C2-type 2.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		TCTTCTCCTTCAAATTCCCTT	0.413													30	41					0	0	0.001786	0	0
IGSF11	152404	broad.mit.edu	37	3	118621455	118621455	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:118621455G>A	uc003ebw.2	-	7	1455	c.1208C>T	c.(1207-1209)TCC>TTC	p.S403F	IGSF11_uc011biv.1_Missense_Mutation_p.S375F|IGSF11_uc003ebx.2_Missense_Mutation_p.S379F|IGSF11_uc003eby.2_Missense_Mutation_p.S402F|IGSF11_uc003ebz.2_Missense_Mutation_p.S378F|IGSF11_uc010hqs.2_Missense_Mutation_p.S402F	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	403	Cytoplasmic (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						GATGGTGTAGGAATGAGTGTG	0.547													23	62					0	0	0.002299	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119121239	119121239	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:119121239C>T	uc003ecj.3	+	10	2172	c.1640C>T	c.(1639-1641)TCT>TTT	p.S547F		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	547					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						GCTGAGACTTCTGCAGGTAAG	0.328													17	32					0	0	0.004990	0	0
PLA1A	51365	broad.mit.edu	37	3	119328383	119328383	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:119328383G>A	uc003ecu.2	+	4	561	c.522G>A	c.(520-522)ATG>ATA	p.M174I	PLA1A_uc003ecv.2_Missense_Mutation_p.M158I|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_Missense_Mutation_p.M1I	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	174					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						TTGGGGGCATGGTGGGACAGC	0.562													31	92					0	0	0.004289	0	0
STXBP5L	9515	broad.mit.edu	37	3	120973808	120973808	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:120973808G>A	uc003eec.3	+	16	1648	c.1508G>A	c.(1507-1509)GGA>GAA	p.G503E	STXBP5L_uc011bji.1_Missense_Mutation_p.G503E	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	503					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GTAGGAGAAGGAAAACAAACA	0.378													7	30					0	0	0.004482	0	0
GOLGB1	2804	broad.mit.edu	37	3	121416026	121416026	+	Nonsense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121416026A>T	uc003eei.3	-	13	3455	c.3329T>A	c.(3328-3330)TTG>TAG	p.L1110*	GOLGB1_uc010hrc.2_Nonsense_Mutation_p.L1115*|GOLGB1_uc003eej.3_Nonsense_Mutation_p.L1076*|GOLGB1_uc011bjm.1_Nonsense_Mutation_p.L996*|GOLGB1_uc010hrd.1_Nonsense_Mutation_p.L1074*	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1110	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TGCTTGGAGCAAATCTATTTG	0.418													38	88					0	0	0.004289	0	0
SLC15A2	6565	broad.mit.edu	37	3	121634077	121634077	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121634077G>A	uc003eep.2	+	6	685	c.532G>A	c.(532-534)GAG>AAG	p.E178K	SLC15A2_uc011bjn.1_Missense_Mutation_p.E147K	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	178					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GTTTCAGGCAGAGGAACGGAC	0.448													13	31					0	0	0.004007	0	0
ILDR1	286676	broad.mit.edu	37	3	121720677	121720677	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121720677C>T	uc003ees.2	-	4	520	c.414G>A	c.(412-414)TGG>TGA	p.W138*	ILDR1_uc003eeq.2_Nonsense_Mutation_p.W150*|ILDR1_uc003eer.2_Nonsense_Mutation_p.W138*|ILDR1_uc010hrg.2_Intron	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	138	Extracellular (Potential).|Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		CTCCATGGTCCCACCACATCA	0.498													26	39					0	0	0.003330	0	0
CASR	846	broad.mit.edu	37	3	121973120	121973120	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121973120G>C	uc003eev.3	+	2	456	c.84G>C	c.(82-84)AAG>AAC	p.K28N	CASR_uc003eew.3_Missense_Mutation_p.K28N	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	28	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GAGCCCAAAAGAAGGGGGACA	0.522													37	74					0	0	0.003271	0	0
CASR	846	broad.mit.edu	37	3	121976007	121976007	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121976007C>T	uc003eev.3	+	3	637	c.265C>T	c.(265-267)CCC>TCC	p.P89S	CASR_uc003eew.3_Missense_Mutation_p.P89S	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	89	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AGCCCTTCTTCCCAACTTGAC	0.448													26	80					0	0	0.004656	0	0
ADCY5	111	broad.mit.edu	37	3	123003528	123003528	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:123003528C>G	uc003egh.1	-	21	3713	c.3713G>C	c.(3712-3714)CGG>CCG	p.R1238P	ADCY5_uc003egg.1_Missense_Mutation_p.R896P	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	1238	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GACCACGCCCCGGCACTCCAG	0.607													32	104					0	0	0.004878	0	0
KALRN	8997	broad.mit.edu	37	3	124418856	124418856	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:124418856G>A	uc003ehg.2	+	56	8099	c.7972G>A	c.(7972-7974)GAG>AAG	p.E2658K	KALRN_uc003ehk.2_Missense_Mutation_p.E961K	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2657	Fibronectin type-III.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CGAGCCCTCGGAGTTTGTGCG	0.597													38	98					0	0	0.002522	0	0
PLXNA1	5361	broad.mit.edu	37	3	126736441	126736441	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:126736441C>T	uc003ejg.2	+	17	3385	c.3381C>T	c.(3379-3381)CCC>CCT	p.P1127P		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1150	Extracellular (Potential).|IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		ACCCTGACCCCGTACTGGAGC	0.642													46	141					0	0	0.003610	0	0
KBTBD12	166348	broad.mit.edu	37	3	127642587	127642587	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:127642587C>T	uc010hsr.2	+	1	686	c.683C>T	c.(682-684)TCT>TTT	p.S228F	KBTBD12_uc003ejy.3_Intron|KBTBD12_uc010hsq.2_Intron|KBTBD12_uc003eka.3_Intron|KBTBD12_uc003ejz.2_Missense_Mutation_p.S228F	NM_207335	NP_997218	Q3ZCT8	KBTBC_HUMAN	kelch domain containing 6	228	BACK.									ovary(1)	1						GTAAATCCTTCTTTTTTAAGA	0.383													22	45					0	0	0.001523	0	0
EEFSEC	60678	broad.mit.edu	37	3	128126937	128126937	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:128126937G>A	uc003eki.2	+	7	1664	c.1626G>A	c.(1624-1626)AAG>AAA	p.K542K	EEFSEC_uc003ekj.2_Missense_Mutation_p.R435K	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	542						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						AGTCCAAGAAGATCCTGACAC	0.692													7	14					0	0	0.003080	0	0
GATA2	2624	broad.mit.edu	37	3	128204626	128204627	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:128204626_128204627CC>TT	uc003ekm.3	-	4	1249_1250	c.814_815GG>AA	c.(814-816)GGG>AAG	p.G272K	GATA2_uc003ekn.3_Missense_Mutation_p.G272K|GATA2_uc003eko.2_Missense_Mutation_p.G272K	NM_001145661	NP_001139133	P23769	GATA2_HUMAN	GATA binding protein 2 isoform 1	272					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(13)|lung(1)|skin(1)	15				GBM - Glioblastoma multiforme(114;0.173)		GGCCGGTCCCCCCAGGAAGCCT	0.644			Mis		AML(CML blast transformation)								6	17					0	0	0.004672	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133661478	133661478	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:133661478G>A	uc003eqa.3	-	11	1870	c.1596C>T	c.(1594-1596)TCC>TCT	p.S532S	SLCO2A1_uc003eqb.3_Silent_p.S456S|SLCO2A1_uc011blv.1_Silent_p.S351S	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	532	Helical; Name=10; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						GGGGGTTGTGGGAGATGCAGG	0.587													17	35					0	0	0.004990	0	0
EPHB1	2047	broad.mit.edu	37	3	134670723	134670723	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:134670723G>A	uc003eqt.2	+	3	854	c.634G>A	c.(634-636)GGG>AGG	p.G212R	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Intron	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	212	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GACTATGACAGGGGCAGAGAG	0.507													66	151					0	0	0.003610	0	0
DZIP1L	199221	broad.mit.edu	37	3	137783575	137783575	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:137783575C>T	uc003erq.2	-	15	2400	c.2037G>A	c.(2035-2037)GAG>GAA	p.E679E		NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	679						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						CTAGCTGCTTCTCCAGGTTTT	0.517													129	322					0	0	0.003610	0	0
MED12L	116931	broad.mit.edu	37	3	150911442	150911442	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:150911442C>T	uc003eyp.2	+	14	2172	c.2134C>T	c.(2134-2136)CCT>TCT	p.P712S	MED12L_uc011bnz.1_Missense_Mutation_p.P572S|MED12L_uc003eyn.2_Missense_Mutation_p.P747S|MED12L_uc003eyo.2_Missense_Mutation_p.P712S	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	712					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AACACATTTTCCTATACCTCT	0.338													22	68					0	0	0.003330	0	0
IGSF10	285313	broad.mit.edu	37	3	151155730	151155730	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:151155730C>T	uc011bod.1	-	6	6619	c.6619G>A	c.(6619-6621)GAT>AAT	p.D2207N	IGSF10_uc011bob.1_Missense_Mutation_p.D234N|IGSF10_uc011boc.1_Missense_Mutation_p.D186N	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2207	Ig-like C2-type 8.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTCCAGAATCGAGCAGTTTC	0.428													23	67					0	0	0.005443	0	0
IGSF10	285313	broad.mit.edu	37	3	151163111	151163111	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:151163111G>A	uc011bod.1	-	4	4658	c.4658C>T	c.(4657-4659)CCA>CTA	p.P1553L		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1553					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGTTAGTGCTGGCATGGGAGT	0.413													46	100					0	0	0.002852	0	0
P2RY1	5028	broad.mit.edu	37	3	152554131	152554131	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:152554131T>A	uc003ezq.2	+	1	1396	c.560T>A	c.(559-561)CTC>CAC	p.L187H		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	187	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TCCCCCATCCTCTTCTACTCA	0.532													23	59					0	0	0.003330	0	0
GPR149	344758	broad.mit.edu	37	3	154055952	154055952	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:154055952C>T	uc003faa.2	-	4	1832	c.1732G>A	c.(1732-1734)GAA>AAA	p.E578K		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	578	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTTTGCCCTTCTGCGCTTACC	0.448													52	113					0	0	0.003610	0	0
SCHIP1	29970	broad.mit.edu	37	3	158980415	158980415	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:158980415C>T	uc003fcq.1	+	4	339	c.234C>T	c.(232-234)TCC>TCT	p.S78S	SCHIP1_uc003fcr.1_5'UTR|IQCJ_uc003fco.2_Silent_p.S78S|IQCJ_uc010hvy.1_Silent_p.S51S|IQCJ_uc003fcp.1_Silent_p.S78S	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	Error:Variant_position_missing_in_Q9P0W5_after_alignment						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			CCTCTGTCTCCTCAGAGAAGC	0.527													28	58					0	0	0.008361	0	0
SI	6476	broad.mit.edu	37	3	164764781	164764781	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:164764781G>A	uc003fei.2	-	16	1797	c.1735C>T	c.(1735-1737)CCT>TCT	p.P579S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	579	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTCTTATTAGGAAAAACTTTT	0.303										HNSCC(35;0.089)			9	16					0	0	0.004482	0	0
SI	6476	broad.mit.edu	37	3	164785275	164785275	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:164785275G>A	uc003fei.2	-	6	550	c.488C>T	c.(487-489)ACT>ATT	p.T163I		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	163	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATTTGGATCAGTAATCTGGAA	0.313										HNSCC(35;0.089)			24	81					0	0	0.005443	0	0
SLITRK3	22865	broad.mit.edu	37	3	164905757	164905757	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:164905757G>A	uc003fej.3	-	2	3306	c.2862C>T	c.(2860-2862)CTC>CTT	p.L954L	SLITRK3_uc003fek.2_Silent_p.L954L	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	954	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CCCTTAACTCGAGGTAATCAC	0.448										HNSCC(40;0.11)			51	140					0	0	0.003610	0	0
WDR49	151790	broad.mit.edu	37	3	167196724	167196724	+	Missense_Mutation	SNP	C	T	T	rs76736291	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:167196724C>T	uc003fev.1	-	15	2342	c.2036G>A	c.(2035-2037)CGA>CAA	p.R679Q	WDR49_uc003feu.1_Missense_Mutation_p.R504Q|WDR49_uc011bpd.1_Missense_Mutation_p.R644Q|WDR49_uc003few.1_3'UTR	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	679										large_intestine(1)|ovary(1)|skin(1)	3						CTTGGCTTTTCGTTCATGATG	0.318													13	35					0	0	0.001368	0	0
LRRC34	151827	broad.mit.edu	37	3	169511529	169511529	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:169511529G>A	uc003ffx.2	-	10	1169	c.1154C>T	c.(1153-1155)TCC>TTC	p.S385F	LRRC34_uc003ffy.2_Missense_Mutation_p.S417F|LRRC34_uc011bpn.1_3'UTR|LRRC34_uc003ffz.2_Missense_Mutation_p.S369F|LRRC34_uc003fga.3_3'UTR	NM_153353	NP_699184	Q8IZ02	LRC34_HUMAN	leucine rich repeat containing 34	385											0	all_cancers(22;4.12e-22)|all_epithelial(15;7.54e-27)|all_lung(20;1.63e-16)|Lung NSC(18;6.92e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			AAGGCCATTGGAGACTTCTGC	0.388													22	46					0	0	0.001882	0	0
LRRC31	79782	broad.mit.edu	37	3	169557848	169557848	+	Silent	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:169557848A>T	uc003fgc.1	-	9	1658	c.1581T>A	c.(1579-1581)GCT>GCA	p.A527A	LRRC31_uc010hwp.1_Silent_p.A471A	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	527										ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			CCTCCTGTGAAGCTGGGAGAA	0.398													8	38					0	0	0.003080	0	0
TNFSF10	8743	broad.mit.edu	37	3	172224702	172224702	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:172224702C>T	uc003fid.2	-	5	521	c.426G>A	c.(424-426)AAG>AAA	p.K142K	TNFSF10_uc003fie.2_Missense_Mutation_p.R93K	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	142	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CCTTTTCATTCTTGGAGTCTG	0.443													9	17					0	0	0.004482	0	0
CCDC39	339829	broad.mit.edu	37	3	180372596	180372596	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:180372596G>A	uc010hxe.2	-	7	999	c.884C>T	c.(883-885)ACG>ATG	p.T295M	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	295					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CTGATATGCCGTTCTACATTT	0.353													11	31					0	0	0.001855	0	0
KLHL6	89857	broad.mit.edu	37	3	183273311	183273311	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183273311C>T	uc003flr.2	-	1	189	c.131G>A	c.(130-132)GGG>GAG	p.G44E	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Missense_Mutation_p.G42E	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	44										haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GACCTTTTCCCCATTTAAGAT	0.498													34	110					0	0	0.003271	0	0
KLHL24	54800	broad.mit.edu	37	3	183368597	183368598	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183368597_183368598CC>TT	uc003flv.2	+	3	748_749	c.453_454CC>TT	c.(451-456)CTCCGT>CTTTGT	p.R152C	KLHL24_uc003flw.2_Missense_Mutation_p.R152C|KLHL24_uc003flx.2_Missense_Mutation_p.R152C	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	152						axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			TTAGTGTTCTCCGTGATGCATG	0.406													30	87					0	0	0.004672	0	0
KLHL24	54800	broad.mit.edu	37	3	183381293	183381293	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183381293G>A	uc003flv.2	+	4	1263	c.968G>A	c.(967-969)CGA>CAA	p.R323Q	KLHL24_uc003flw.2_Missense_Mutation_p.R323Q|KLHL24_uc003flx.2_Missense_Mutation_p.R323Q	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	323	Kelch 1.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GGATGTGAGCGAGTTGGAGGA	0.348													21	55					0	0	0.003954	0	0
HTR3D	200909	broad.mit.edu	37	3	183756374	183756374	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183756374G>A	uc011bqv.1	+	7	1097	c.1097G>A	c.(1096-1098)GGA>GAA	p.G366E	HTR3D_uc003fmj.2_Missense_Mutation_p.G191E|HTR3D_uc011bqu.1_Missense_Mutation_p.G316E|HTR3D_uc010hxp.2_Missense_Mutation_p.G145E	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	366	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCCCAGAAGGGAAATAAGGGC	0.512													6	18					0	0	0.001984	0	0
HTR3E	285242	broad.mit.edu	37	3	183822694	183822695	+	Missense_Mutation	DNP	CC	TT	TT	rs145422207		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183822694_183822695CC>TT	uc010hxq.2	+	5	975_976	c.509_510CC>TT	c.(508-510)CCC>CTT	p.P170L	HTR3E_uc003fml.3_Missense_Mutation_p.P155L|HTR3E_uc003fmm.2_Missense_Mutation_p.P185L|HTR3E_uc010hxr.2_Missense_Mutation_p.P196L|HTR3E_uc003fmn.2_Missense_Mutation_p.P170L	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	170	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TTCTACTTCCCCTTCGACCAGC	0.475													19	68					0	0	0.004672	0	0
ALG3	10195	broad.mit.edu	37	3	183961677	183961677	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183961677G>A	uc003fne.2	-	6	865	c.834C>T	c.(832-834)TTC>TTT	p.F278F	ALG3_uc011brc.1_Silent_p.F243F|ALG3_uc011brd.1_Silent_p.F222F|ALG3_uc011bre.1_Silent_p.F230F|ALG3_uc003fnf.1_Silent_p.F238F	NM_005787	NP_005778	Q92685	ALG3_HUMAN	alpha-1,3-mannosyltransferase ALG3 isoform a	278					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity				0	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCTCTGGGAGGAAGCGCCAGT	0.632													15	25					0	0	0.003163	0	0
ECE2	9718	broad.mit.edu	37	3	183995965	183995965	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183995965G>A	uc003fni.3	+	6	1006	c.968G>A	c.(967-969)TGG>TAG	p.W323*	ECE2_uc011brg.1_Nonsense_Mutation_p.W251*|ECE2_uc011brh.1_Nonsense_Mutation_p.W176*|ECE2_uc003fnl.3_Nonsense_Mutation_p.W251*|ECE2_uc003fnm.3_Nonsense_Mutation_p.W205*|ECE2_uc003fnk.3_Nonsense_Mutation_p.W176*|ECE2_uc011bri.1_Nonsense_Mutation_p.W238*|ECE2_uc010hxv.2_5'UTR	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	323	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATTGGTGGTTGGAACATTACG	0.542													12	53					0	0	0.000978	0	0
VPS8	23355	broad.mit.edu	37	3	184632795	184632796	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:184632795_184632796CC>TT	uc003fpb.1	+	26	2381_2382	c.2210_2211CC>TT	c.(2209-2211)CCC>CTT	p.P737L	VPS8_uc010hyd.1_Missense_Mutation_p.P647L|VPS8_uc010hye.1_Missense_Mutation_p.P166L	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	739							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			CGTGCCTATCCCCTTGGTGACA	0.431													19	82					0	0	0.004672	0	0
MAP3K13	9175	broad.mit.edu	37	3	185161269	185161269	+	Silent	SNP	C	T	T	rs138574503		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:185161269C>T	uc010hyf.2	+	5	962	c.696C>T	c.(694-696)ATC>ATT	p.I232I	MAP3K13_uc011brt.1_Silent_p.I25I|MAP3K13_uc003fph.3_5'UTR|MAP3K13_uc011bru.1_Silent_p.I88I|MAP3K13_uc003fpi.2_Silent_p.I232I|MAP3K13_uc010hyg.2_Intron	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	232	Protein kinase.			CII -> YLY (in Ref. 6; CAA80915).	activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			ATTGTATTATCATGGAATACT	0.348													26	70					0	0	0.006320	0	0
ETV5	2119	broad.mit.edu	37	3	185783621	185783621	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:185783621C>T	uc003fpz.2	-	8	1138	c.891G>A	c.(889-891)CGG>CGA	p.R297R	ETV5_uc003fpy.2_Silent_p.R339R	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	297					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			CGCAGTAATCCCGAGGCTCCT	0.507			T	TMPRSS2|SCL45A3	Prostate 								65	135					0	0	0.003610	0	0
KNG1	3827	broad.mit.edu	37	3	186459557	186459557	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:186459557G>A	uc011bsa.1	+	10	1584	c.1372G>A	c.(1372-1374)GGA>AGA	p.G458R	KNG1_uc003fqr.2_Intron	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	458	|His-rich.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GCACCAAAGAGGACATGGCCT	0.478													11	24					0	0	0.001368	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186792044	186792044	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:186792044C>T	uc003frb.2	+	7	1334	c.902C>T	c.(901-903)CCT>CTT	p.P301L	ST6GAL1_uc003frc.2_Missense_Mutation_p.P70L|ST6GAL1_uc003frd.2_Missense_Mutation_p.P301L	NM_173216	NP_775323	P15907	SIAT1_HUMAN	ST6 beta-galactosamide	301	Lumenal (Potential).				humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)	1	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		CCCCAGATGCCTTGGGAGCTA	0.473													33	103					0	0	0.005524	0	0
RTP4	64108	broad.mit.edu	37	3	187088772	187088772	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:187088772C>T	uc003frm.2	+	2	414	c.352C>T	c.(352-354)CTG>TTG	p.L118L		NM_022147	NP_071430	Q96DX8	RTP4_HUMAN	28kD interferon responsive protein	118	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding				0	all_cancers(143;4.66e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		TCTGAGCAACCTGGTGCAGCA	0.502													8	29					0	0	0.004482	0	0
RTP4	64108	broad.mit.edu	37	3	187089093	187089093	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:187089093C>T	uc003frm.2	+	2	735	c.673C>T	c.(673-675)CCA>TCA	p.P225S		NM_022147	NP_071430	Q96DX8	RTP4_HUMAN	28kD interferon responsive protein	225	Helical; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding				0	all_cancers(143;4.66e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		AGACCCAGATCCACTGAACAT	0.428													13	27					0	0	0.001855	0	0
TP63	8626	broad.mit.edu	37	3	189455616	189455616	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:189455616C>T	uc003fry.2	+	2	239	c.150C>T	c.(148-150)CTC>CTT	p.L50L	TP63_uc003frx.2_Silent_p.L50L|TP63_uc003frz.2_Silent_p.L50L|TP63_uc010hzc.1_Silent_p.L50L	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	50	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ATGAATTCCTCAGTCCAGAGG	0.398									Hay-Wells_syndrome	HNSCC(45;0.13)			16	42					0	0	0.004007	0	0
FGF12	2257	broad.mit.edu	37	3	192125915	192125915	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:192125915G>A	uc003fsx.2	-	1	924	c.98C>T	c.(97-99)CCC>CTC	p.P33L	FGF12_uc003fsy.2_Intron	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	33	Bipartite nuclear localization signal (Potential).				cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		GTCTTTGCTGGGGCTGGAGCG	0.677													34	56					0	0	0.003271	0	0
MUC4	4585	broad.mit.edu	37	3	195517616	195517616	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:195517616C>T	uc011bto.1	-	2	1295	c.835G>A	c.(835-837)GAG>AAG	p.E279K	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.E161K	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	284					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GATGATGTCTCCCCTGGGTTT	0.468													19	54					0	0	0.007413	0	0
ZDHHC19	131540	broad.mit.edu	37	3	195936327	195936327	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:195936327G>A	uc003fwc.2	-	3	442	c.328C>T	c.(328-330)CGC>TGC	p.R110C	ZDHHC19_uc010hzz.2_RNA|ZDHHC19_uc010iaa.2_RNA|ZDHHC19_uc010iab.2_RNA	NM_001039617	NP_001034706	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC domain containing 19	110						integral to membrane	acyltransferase activity|zinc ion binding			ovary(3)	3	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		CATTGCAGGCGGAAGGCCCCG	0.652													4	19					0	0	0.000248	0	0
LRRC33	375387	broad.mit.edu	37	3	196386840	196386840	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:196386840G>A	uc003fwv.2	+	3	430	c.326G>A	c.(325-327)AGC>AAC	p.S109N		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	109	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CACCTGCGCAGCCTGGTCCTG	0.667													12	14					0	0	0.001368	0	0
MFSD7	84179	broad.mit.edu	37	4	679631	679631	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:679631G>A	uc003gay.2	-	4	635	c.578C>T	c.(577-579)CCG>CTG	p.P193L	MFSD7_uc003gaw.2_5'Flank|MFSD7_uc003gax.2_Missense_Mutation_p.P193L|MFSD7_uc003gaz.2_Intron|MFSD7_uc003gba.2_Intron|MFSD7_uc003gbb.1_Missense_Mutation_p.P129L	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	193	Helical; (Potential).				transmembrane transport	integral to membrane					0						CACCATTAACGGAATGTCCTC	0.587													15	73					0	0	0.004007	0	0
C4orf42	92070	broad.mit.edu	37	4	1244873	1244873	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:1244873C>T	uc003gcz.1	+	1	697	c.512C>T	c.(511-513)TCC>TTC	p.S171F	CTBP1_uc003gcu.1_5'Flank|CTBP1_uc003gcv.1_5'Flank|C4orf42_uc003gcy.1_RNA	NM_052861	NP_443093			hypothetical protein LOC92070											ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0101)	Colorectal(103;0.188)		TCCATGGCCTCCGTCTACACA	0.587													9	73					0	0	0.000978	0	0
CRIPAK	285464	broad.mit.edu	37	4	1388354	1388354	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:1388354C>T	uc003gdf.2	+	1	3015	c.55C>T	c.(55-57)CCA>TCA	p.P19S		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	19					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			TCACACGTGCCCATGTGGAGT	0.488													19	341					0	0	0.001882	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2274994	2274994	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:2274994C>T	uc003gex.1	-	10	2548	c.2229G>A	c.(2227-2229)ACG>ACA	p.T743T	ZFYVE28_uc011bvk.1_Silent_p.T673T|ZFYVE28_uc011bvl.1_Silent_p.T713T|ZFYVE28_uc003gew.1_Silent_p.T629T	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	743					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						TGGCATAGTTCGTCTGCAGCT	0.537													98	130					0	0	0.003610	0	0
FAM193A	8603	broad.mit.edu	37	4	2648484	2648484	+	Silent	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:2648484C>A	uc010icl.2	+	5	714	c.363C>A	c.(361-363)TCC>TCA	p.S121S	FAM193A_uc010ick.2_Silent_p.S321S|FAM193A_uc003gfd.2_Silent_p.S121S|FAM193A_uc011bvm.1_Silent_p.S121S|FAM193A_uc011bvn.1_Silent_p.S121S|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	121	Potential.									ovary(3)	3						ACCAGCGTTCCGAGGAGGAGC	0.597													6	217					3.59834e-05	5.45439e-05	0.001168	1	0
HTT	3064	broad.mit.edu	37	4	3101017	3101017	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:3101017C>T	uc011bvq.1	+	4	515	c.370C>T	c.(370-372)CAG>TAG	p.Q124*		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	122					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TCCAGAATTTCAGAAACTTCT	0.264													82	80					0	0	0.003610	0	0
HTT	3064	broad.mit.edu	37	4	3148619	3148619	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:3148619C>T	uc011bvq.1	+	26	3390	c.3245C>T	c.(3244-3246)CCA>CTA	p.P1082L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1080					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GCTTGGTTCCCATTGGATCTC	0.507													133	770					0	0	0.003610	0	0
HTT	3064	broad.mit.edu	37	4	3237335	3237335	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:3237335C>T	uc011bvq.1	+	64	8766	c.8621C>T	c.(8620-8622)TCC>TTC	p.S2874F		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2872					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TCCACCCCCTCCATCATTTAC	0.577													6	66					0	0	0.004482	0	0
HGFAC	3083	broad.mit.edu	37	4	3446151	3446151	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:3446151G>A	uc003ghc.2	+	6	715	c.712G>A	c.(712-714)GAA>AAA	p.E238K	HGFAC_uc010icw.2_Missense_Mutation_p.E238K	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	238	Fibronectin type-I.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GACCTGGTGCGAAGGCACCCG	0.697													13	16					0	0	0.003163	0	0
D4S234E	27065	broad.mit.edu	37	4	4411407	4411407	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:4411407C>T	uc011bvz.1	+	7	1635	c.354C>T	c.(352-354)CTC>CTT	p.L118L	D4S234E_uc011bwa.1_Silent_p.L79L|D4S234E_uc003ghz.2_Silent_p.L118L|D4S234E_uc003gia.2_Silent_p.L118L|D4S234E_uc003gib.2_Silent_p.L118L	NM_014392	NP_055207	P42857	NSG1_HUMAN	brain neuron cytoplasmic protein 1	118	Lumenal (Potential).				dopamine receptor signaling pathway	Golgi membrane|integral to membrane|nucleus	dopamine receptor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)		GGTTCGTCCTCAAGGTAAAAC	0.597													21	94					0	0	0.002299	0	0
EVC	2121	broad.mit.edu	37	4	5806507	5806507	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:5806507C>T	uc003gil.1	+	17	2684	c.2500C>T	c.(2500-2502)CCT>TCT	p.P834S	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	834					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				ACTCAGCAACCCTTCGTCGGG	0.547													25	140					0	0	0.007291	0	0
AFAP1	60312	broad.mit.edu	37	4	7844898	7844898	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:7844898A>G	uc003gkg.1	-	5	787	c.514T>C	c.(514-516)TTG>CTG	p.L172L	AFAP1_uc011bwk.1_Silent_p.L172L	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	172	PH 1.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						ACGCAGAGCAACTTGGTCCAC	0.532													27	138					0	0	0.008361	0	0
ACOX3	8310	broad.mit.edu	37	4	8383293	8383294	+	Nonsense_Mutation	DNP	GG	AA	AA	rs146945288		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:8383293_8383294GG>AA	uc010idk.2	-	14	1723_1724	c.1578_1579CC>TT	c.(1576-1581)CTCCGA>CTTTGA	p.R527*	ACOX3_uc003glc.3_Nonsense_Mutation_p.R527*|ACOX3_uc003gld.3_Nonsense_Mutation_p.R527*|ACOX3_uc003gle.1_Nonsense_Mutation_p.R432*	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	527					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						TAAGTCTCTCGGAGCAGGTAGC	0.406													32	159					0	0	0.004672	0	0
ACOX3	8310	broad.mit.edu	37	4	8401291	8401291	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:8401291G>A	uc010idk.2	-	8	1010	c.865C>T	c.(865-867)CCC>TCC	p.P289S	ACOX3_uc003glc.3_Missense_Mutation_p.P289S|ACOX3_uc003gld.3_Missense_Mutation_p.P289S|ACOX3_uc003gle.1_Missense_Mutation_p.P194S	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	289					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						ACCTTAAAGGGGCTGACATAG	0.622													19	105					0	0	0.008871	0	0
C4orf23	152992	broad.mit.edu	37	4	8472850	8472850	+	Missense_Mutation	SNP	C	T	T	rs146322919	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:8472850C>T	uc003glg.1	+	10	1468	c.1280C>T	c.(1279-1281)ACG>ATG	p.T427M	C4orf23_uc003glh.1_Missense_Mutation_p.T264M|C4orf23_uc003gli.1_5'Flank	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	656					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						GAGCTGGACACGGAGACCCTG	0.567													34	217					0	0	0.003755	0	0
BOD1L	259282	broad.mit.edu	37	4	13605633	13605633	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:13605633G>A	uc003gmz.1	-	10	3008	c.2891C>T	c.(2890-2892)CCT>CTT	p.P964L	BOD1L_uc010idr.1_Missense_Mutation_p.P301L	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	964	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						TTCTTCAAAAGGTTTGTCTTC	0.408													68	443					0	0	0.003610	0	0
CD38	952	broad.mit.edu	37	4	15835868	15835868	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:15835868G>A	uc011bxc.1	+	4	635	c.528G>A	c.(526-528)TGG>TGA	p.W176*	CD38_uc003gol.1_Nonsense_Mutation_p.W176*	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	176	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						GCCCAGACTGGAGAAAGGACT	0.408													21	109					0	0	0.002780	0	0
SLIT2	9353	broad.mit.edu	37	4	20255468	20255468	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:20255468C>T	uc003gpr.1	+	1	234	c.30C>T	c.(28-30)TCC>TCT	p.S10S	SLIT2_uc003gps.1_Silent_p.S10S	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	10					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AGATGCTGTCCCTGTCGCTGG	0.672													25	111					0	0	0.003954	0	0
SLIT2	9353	broad.mit.edu	37	4	20555447	20555447	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:20555447C>T	uc003gpr.1	+	26	2785	c.2581C>T	c.(2581-2583)CTT>TTT	p.L861F	SLIT2_uc003gps.1_Missense_Mutation_p.L853F	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	861	LRRCT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AGCCAACCCTCTTTACTGTGA	0.358													11	91					0	0	0.001368	0	0
CCDC149	91050	broad.mit.edu	37	4	24833217	24833217	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:24833217G>A	uc011bxr.1	-	10	1020	c.876C>T	c.(874-876)TCC>TCT	p.S292S	CCDC149_uc003grc.2_Silent_p.S292S|CCDC149_uc003grb.2_RNA|CCDC149_uc003grd.2_Intron|CCDC149_uc003gre.2_Silent_p.S237S|CCDC149_uc011bxq.1_Silent_p.S165S	NM_173463	NP_775734	B4DZG3	B4DZG3_HUMAN	coiled-coil domain containing 149 isoform 1	292											0		Breast(46;0.173)				GGTCAGAAATGGACTGCGGAG	0.463													15	67					0	0	0.004007	0	0
LGI2	55203	broad.mit.edu	37	4	25030200	25030200	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:25030200C>T	uc003grf.2	-	2	297	c.198G>A	c.(196-198)CTG>CTA	p.L66L		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	66						extracellular region					0		Breast(46;0.173)				TTACCAGGCTCCTACGGGCAA	0.478													5	43					0	0	0.001168	0	0
SEL1L3	23231	broad.mit.edu	37	4	25750168	25750168	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:25750168C>T	uc003gru.3	-	24	3430	c.3278G>A	c.(3277-3279)AGA>AAA	p.R1093K	SEL1L3_uc003grt.2_Missense_Mutation_p.R141K	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	1093						integral to membrane	binding				0						CTGGGATGGTCTTGGAGGGGG	0.537													3	21					0	0	0.004672	0	0
ARAP2	116984	broad.mit.edu	37	4	36163142	36163142	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:36163142G>A	uc003gsq.1	-	12	2542	c.2204C>T	c.(2203-2205)TCC>TTC	p.S735F	ARAP2_uc003gsr.1_Missense_Mutation_p.S735F	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	735	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TCTAACCTTGGAATCTTTTGG	0.348													22	98					0	0	0.003330	0	0
TLR1	7096	broad.mit.edu	37	4	38799133	38799133	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:38799133G>A	uc003gtl.2	-	4	1594	c.1320C>T	c.(1318-1320)TTC>TTT	p.F440F		NM_003263	NP_003254	Q15399	TLR1_HUMAN	toll-like receptor 1 precursor	440	Extracellular (Potential).|LRR 9.				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			lung(2)|skin(2)|prostate(1)	5						GTAAACATCTGAAAATAGTGT	0.328													23	156					0	0	0.002780	0	0
RFC1	5981	broad.mit.edu	37	4	39304682	39304682	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:39304682G>A	uc003gty.1	-	16	2337	c.2203C>T	c.(2203-2205)CAG>TAG	p.Q735*	RFC1_uc003gtx.1_Nonsense_Mutation_p.Q734*	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	735					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						TGAATTACCTGAATTCCTCCC	0.428													27	143					0	0	0.007291	0	0
KLB	152831	broad.mit.edu	37	4	39409047	39409047	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:39409047C>T	uc003gua.2	+	1	575	c.478C>T	c.(478-480)CCC>TCC	p.P160S	KLB_uc011byj.1_Missense_Mutation_p.P160S	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	160	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						AAGGCTTTTCCCCGATGGAAT	0.383													56	130					0	0	0.003610	0	0
PDS5A	23244	broad.mit.edu	37	4	39929628	39929628	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:39929628G>A	uc003guv.3	-	3	835	c.295C>T	c.(295-297)CGT>TGT	p.R99C	PDS5A_uc010ifo.2_Missense_Mutation_p.R59C|PDS5A_uc003guw.3_Missense_Mutation_p.R99C	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	99					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						GCATAGATACGAAAGATATCA	0.398													15	99					0	0	0.003163	0	0
RBM47	54502	broad.mit.edu	37	4	40434799	40434799	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:40434799G>A	uc003gvc.2	-	6	2121	c.1411C>T	c.(1411-1413)CAC>TAC	p.H471Y	RBM47_uc003gvd.2_Missense_Mutation_p.H402Y|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.H433Y	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	471						nucleus	nucleotide binding|RNA binding			breast(3)	3						TCCACTGTGTGGATTTTGCCA	0.413													15	76					0	0	0.003163	0	0
PHOX2B	8929	broad.mit.edu	37	4	41750415	41750415	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:41750415C>T	uc003gwf.3	-	1	573	c.213G>A	c.(211-213)AGG>AGA	p.R71R		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	71					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						TCTGGTGGTCCCTGAGGGTGC	0.602			Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				9	84					0	0	0.008291	0	0
ATP10D	57205	broad.mit.edu	37	4	47517562	47517562	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:47517562G>A	uc003gxk.1	+	3	524	c.360G>A	c.(358-360)AAG>AAA	p.K120K	ATP10D_uc003gxj.3_Silent_p.K120K	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	120	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CCTTCCAAAAGGAAATCACCA	0.413													39	147					0	0	0.002222	0	0
ATP10D	57205	broad.mit.edu	37	4	47527602	47527602	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:47527602C>T	uc003gxk.1	+	5	883	c.719C>T	c.(718-720)TCC>TTC	p.S240F	ATP10D_uc003gxj.3_Missense_Mutation_p.S240F	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	240	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GAGAAGTTTTCCAGTAGGATA	0.353													10	73					0	0	0.006214	0	0
SLC10A4	201780	broad.mit.edu	37	4	48490949	48490949	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:48490949C>T	uc003gyc.2	+	3	1526	c.1307C>T	c.(1306-1308)TCT>TTT	p.S436F	ZAR1_uc003gyd.2_5'Flank	NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	436	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1						GCTCAGACTTCTCTCTAAATG	0.353													33	56					0	0	0.004878	0	0
OCIAD2	132299	broad.mit.edu	37	4	48894788	48894788	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:48894788C>T	uc003gyt.2	-	6	586	c.383_splice	c.e6+1	p.R128_splice	OCIAD2_uc003gyu.2_Intron	NM_001014446	NP_001014446	Q56VL3	OCAD2_HUMAN	OCIA domain containing 2 isoform 1							endosome					0						AGATTACAAACCTGTTATGCT	0.328													50	297					0	0	0.003610	0	0
CWH43	80157	broad.mit.edu	37	4	49019268	49019268	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:49019268C>T	uc003gyv.2	+	9	1371	c.1189C>T	c.(1189-1191)CTG>TTG	p.L397L	CWH43_uc011bzl.1_Silent_p.L370L	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	397	Helical; (Potential).				GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						CTGTTTAGTTCTGTGGCTGCT	0.368													32	85					0	0	0.003271	0	0
SPATA18	132671	broad.mit.edu	37	4	52928431	52928431	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:52928431C>T	uc003gzl.2	+	4	633	c.355C>T	c.(355-357)CGG>TGG	p.R119W	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.R119W|SPATA18_uc003gzk.1_Missense_Mutation_p.R119W	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	119	Potential.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCCTCGGGATCGGGATATGCA	0.318													53	132					0	0	0.003610	0	0
SPATA18	132671	broad.mit.edu	37	4	52944959	52944959	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:52944959C>T	uc003gzl.2	+	8	1357	c.1079C>T	c.(1078-1080)TCG>TTG	p.S360L	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.S328L|SPATA18_uc003gzk.1_Missense_Mutation_p.S360L	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	360					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GTGAGAAAATCGTTGACACCA	0.378													12	153					0	0	0.001368	0	0
GSX2	170825	broad.mit.edu	37	4	54967870	54967870	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:54967870G>A	uc010igp.1	+	2	960	c.696G>A	c.(694-696)AGG>AGA	p.R232R	PDGFRA_uc003haa.2_Intron	NM_133267	NP_573574	Q9BZM3	GSX2_HUMAN	GS homeobox 2	232	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			GACTCCGGAGGATTGAAATCG	0.532													29	260					0	0	0.008361	0	0
PDGFRA	5156	broad.mit.edu	37	4	55138611	55138611	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:55138611G>A	uc003han.3	+	9	1619	c.1288G>A	c.(1288-1290)GGA>AGA	p.G430R	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.G324R|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	430	Ig-like C2-type 5.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTCAACTGGGGGACAGACGGT	0.473			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			24	150					0	0	0.002780	0	0
KDR	3791	broad.mit.edu	37	4	55976878	55976879	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:55976878_55976879CC>TT	uc003has.2	-	8	1335_1336	c.1033_1034GG>AA	c.(1033-1035)GGG>AAG	p.G345K	KDR_uc003hat.1_Missense_Mutation_p.G345K|KDR_uc011bzx.1_Missense_Mutation_p.G345K	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	345	Ig-like C2-type 4.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GACACGCTCCCCCACCGTGGCT	0.416			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			41	179					0	0	0.004672	0	0
KDR	3791	broad.mit.edu	37	4	55984928	55984928	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:55984928C>T	uc003has.2	-	3	503	c.201G>A	c.(199-201)CAG>CAA	p.Q67Q	KDR_uc003hat.1_Silent_p.Q67Q|KDR_uc011bzx.1_Silent_p.Q67Q	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	67	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CACTGCCACTCTGATTATTGG	0.468			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			19	137					0	0	0.002780	0	0
NMU	10874	broad.mit.edu	37	4	56466727	56466727	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:56466727G>A	uc003hbc.2	-	8	557	c.451C>T	c.(451-453)CCC>TCC	p.P151S	NMU_uc003hbd.1_RNA|NMU_uc010igv.1_RNA|NMU_uc010igw.1_Missense_Mutation_p.P66S|NMU_uc010igx.1_RNA	NM_006681	NP_006672	P48645	NMU_HUMAN	neuromedin U precursor	151					neuropeptide signaling pathway	extracellular region					0	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		CTTGCAAAGGGACTTTGGAAT	0.313													21	44					0	0	0.001882	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182491	57182492	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:57182491_57182492CC>TT	uc003hbk.2	+	8	3214_3215	c.2823_2824CC>TT	c.(2821-2826)AGCCAG>AGTTAG	p.Q942*	KIAA1211_uc010iha.2_Nonsense_Mutation_p.Q935*|KIAA1211_uc011bzz.1_Nonsense_Mutation_p.Q852*|KIAA1211_uc003hbm.1_Nonsense_Mutation_p.Q828*	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	942	Pro-rich.									ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CGGCCAGCAGCCAGACCCCGGC	0.649													6	30					0	0	0.004672	0	0
LPHN3	23284	broad.mit.edu	37	4	62845460	62845460	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:62845460C>T	uc010ihh.2	+	15	2954	c.2781C>T	c.(2779-2781)TTC>TTT	p.F927F	LPHN3_uc003hcq.3_Silent_p.F927F|LPHN3_uc003hct.2_Silent_p.F320F	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	914	Helical; Name=2; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AGCTGCTCTTCCTGATTGGGA	0.453													38	141					0	0	0.005524	0	0
LPHN3	23284	broad.mit.edu	37	4	62935951	62935951	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:62935951C>T	uc010ihh.2	+	23	3908	c.3735C>T	c.(3733-3735)GAC>GAT	p.D1245D	LPHN3_uc003hcq.3_3'UTR|LPHN3_uc003hct.2_Silent_p.D629D	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1223	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AAATCATAGACCGTGGCTATA	0.453													7	27					0	0	0.001984	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68795664	68795664	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:68795664T>G	uc003hdr.1	-	5	545	c.424A>C	c.(424-426)ATC>CTC	p.I142L	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.I139L	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	142	SEA.|Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						TGATTTAAGATGCTTTGGATT	0.403													34	36					0	0	0.003271	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69101868	69101868	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:69101868C>T	uc003hdw.3	-	3	376	c.240_splice	c.e3+1	p.K80_splice		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B						proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						CTCTGATTTACCTTAGTCTCA	0.284													7	12					0	0	0.001984	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156380	70156380	+	Silent	SNP	G	A	A	rs143921369		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:70156380G>A	uc003hej.2	+	5	1163	c.1161G>A	c.(1159-1161)GGG>GGA	p.G387G	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	387					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.G387G(1)		skin(1)	1					Flunitrazepam(DB01544)	TCTACCATGGGATCCCTATGG	0.428													61	91					0	0	0.003610	0	0
PROL1	58503	broad.mit.edu	37	4	71275427	71275427	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:71275427C>T	uc003hfi.2	+	3	556	c.382C>T	c.(382-384)CCT>TCT	p.P128S		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	128	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				TCCTCCTATTCCTTTTTTTCT	0.433													38	54					0	0	0.006999	0	0
MUC7	4589	broad.mit.edu	37	4	71347507	71347507	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:71347507C>T	uc011cat.1	+	4	1334	c.1046C>T	c.(1045-1047)TCA>TTA	p.S349L	MUC7_uc011cau.1_Missense_Mutation_p.S349L|MUC7_uc003hfj.2_Missense_Mutation_p.S349L|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	349						extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			CAACCAACTTCAGCTCCTGGC	0.378													31	42					0	0	0.001786	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73185051	73185051	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:73185051G>A	uc003hgk.1	-	9	1387	c.1350C>T	c.(1348-1350)ATC>ATT	p.I450I		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	450	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGACATACTGGATATATCTTT	0.423													23	23					0	0	0.004656	0	0
ANKRD17	26057	broad.mit.edu	37	4	73956602	73956602	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:73956602G>A	uc003hgp.2	-	29	6860	c.6743C>T	c.(6742-6744)CCC>CTC	p.P2248L	ANKRD17_uc003hgo.2_Missense_Mutation_p.P2135L|ANKRD17_uc003hgq.2_Missense_Mutation_p.P1997L|ANKRD17_uc003hgr.2_Missense_Mutation_p.P2247L	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2248					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AAATGGTAAGGGGGCACTGAA	0.463													61	91					0	0	0.003610	0	0
CCNI	10983	broad.mit.edu	37	4	77977123	77977123	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:77977123G>A	uc003hkm.2	-	5	995	c.451C>T	c.(451-453)CTT>TTT	p.L151F	CCNI_uc011ccb.1_Missense_Mutation_p.L137F	NM_006835	NP_006826	Q14094	CCNI_HUMAN	cyclin I	151					spermatogenesis					ovary(1)	1						ACAATATGAAGAAAATCCAAT	0.318													27	35					0	0	0.006320	0	0
CNOT6L	246175	broad.mit.edu	37	4	78669520	78669520	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:78669520G>A	uc011ccd.1	-	6	640	c.509C>T	c.(508-510)CCT>CTT	p.P170L	CNOT6L_uc003hks.2_Missense_Mutation_p.P170L|CNOT6L_uc003hkt.1_Missense_Mutation_p.P13L|CNOT6L_uc011cce.1_Missense_Mutation_p.P170L	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	170					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						TGGCCTCGGAGGAAGCTGCTC	0.313													32	48					0	0	0.005524	0	0
NAA11	84779	broad.mit.edu	37	4	80246504	80246504	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:80246504C>T	uc003hlt.3	-	1	668	c.528G>A	c.(526-528)GAG>GAA	p.E176E		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	176						cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						TCTCCTGGTTCTCCCTGGAGC	0.537													15	17					0	0	0.004990	0	0
CDS1	1040	broad.mit.edu	37	4	85525461	85525461	+	Silent	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:85525461T>C	uc011ccv.1	+	2	681	c.183T>C	c.(181-183)ATT>ATC	p.I61I		NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	61					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		TTCCGGAAATTCCACCATCCT	0.343													23	29					0	0	0.002780	0	0
CDS1	1040	broad.mit.edu	37	4	85525463	85525463	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:85525463C>T	uc011ccv.1	+	2	683	c.185C>T	c.(184-186)CCA>CTA	p.P62L		NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	62					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		CCGGAAATTCCACCATCCTCA	0.343													23	29					0	0	0.003330	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86916189	86916189	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:86916189G>A	uc003hpk.2	+	9	1831	c.1382G>A	c.(1381-1383)AGG>AAG	p.R461K	ARHGAP24_uc003hpl.2_Missense_Mutation_p.R366K|ARHGAP24_uc010ikf.2_Missense_Mutation_p.R376K|ARHGAP24_uc003hpm.2_Missense_Mutation_p.R368K	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	461					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CAGGCCAGAAGGAGCTCTTCA	0.517													18	13					0	0	0.004990	0	0
HSD17B13	345275	broad.mit.edu	37	4	88235068	88235068	+	Missense_Mutation	SNP	G	A	A	rs142648167	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:88235068G>A	uc003hqo.2	-	5	665	c.602C>T	c.(601-603)TCA>TTA	p.S201L	HSD17B13_uc010ikk.2_Missense_Mutation_p.S165L	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	201						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		CTGAAGTTCTGATGTCAGACC	0.433													13	15					0	0	0.001855	0	0
HERC6	55008	broad.mit.edu	37	4	89311825	89311825	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:89311825G>A	uc011cdi.1	+	4	641	c.458G>A	c.(457-459)GGA>GAA	p.G153E	HERC6_uc003hrp.1_RNA|HERC6_uc011cdj.1_Missense_Mutation_p.G153E|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	153	RCC1 3.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		TTTTCGTGGGGAAAGAACAGC	0.478													16	11					0	0	0.006122	0	0
GPRIN3	285513	broad.mit.edu	37	4	90171111	90171111	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:90171111G>A	uc003hsm.1	-	2	670	c.151C>T	c.(151-153)CCT>TCT	p.P51S		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	51										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GGTTCTGCAGGGGCACCTGAA	0.562													32	32					0	0	0.002096	0	0
UNC5C	8633	broad.mit.edu	37	4	96106277	96106278	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:96106277_96106278CC>TT	uc003htp.1	-	13	2360_2361	c.2206_2207GG>AA	c.(2206-2208)GGC>AAC	p.G736N	UNC5C_uc010ilc.1_Missense_Mutation_p.G755N	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	736	Cytoplasmic (Potential).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GTGGGTGCTGCCTTTAAAATGA	0.47													26	45					0	0	0.004672	0	0
ADH1C	126	broad.mit.edu	37	4	100268182	100268182	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:100268182C>T	uc003huu.2	-	5	325	c.240G>A	c.(238-240)GGG>GGA	p.G80G		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	80					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	CTGTAGTCACCCCTTCTCAAA	0.463									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				53	88					0	0	0.003610	0	0
BANK1	55024	broad.mit.edu	37	4	102994886	102994886	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:102994886A>G	uc003hvy.3	+	16	2618	c.2344A>G	c.(2344-2346)AAG>GAG	p.K782E	BANK1_uc003hvx.3_Missense_Mutation_p.K767E|BANK1_uc010ill.2_Missense_Mutation_p.K649E|BANK1_uc003hvz.3_Missense_Mutation_p.K752E	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	782					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TTTCTGTTGCAAGAAAGATCA	0.318													22	31					0	0	0.003954	0	0
TET2	54790	broad.mit.edu	37	4	106156057	106156057	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:106156057G>A	uc003hxk.2	+	3	1344	c.958G>A	c.(958-960)GAA>AAA	p.E320K	TET2_uc011cez.1_Missense_Mutation_p.E341K|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.E320K|TET2_uc003hxi.1_Missense_Mutation_p.E320K	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	320					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.E320*(1)		haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TCAGAAACCAGAACAACTACA	0.433			Mis N|F		MDS								10	14					0	0	0.001368	0	0
EEF1A1P9	441032	broad.mit.edu	37	4	106406073	106406073	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:106406073C>T	uc003hxt.1	+	1	211	c.81C>T	c.(79-81)ATC>ATT	p.I27I		NR_003586				SubName: Full=Eukaryotic translation elongation factor 1 alpha; Flags: Fragment;												0						CCATTGATATCTCTTTGTGGA	0.448													27	33					0	0	0.008361	0	0
NPNT	255743	broad.mit.edu	37	4	106863686	106863686	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:106863686C>T	uc003hya.2	+	8	1191	c.986C>T	c.(985-987)CCA>CTA	p.P329L	NPNT_uc011cfc.1_Missense_Mutation_p.P346L|NPNT_uc011cfd.1_Missense_Mutation_p.P359L|NPNT_uc011cfe.1_Missense_Mutation_p.P359L|NPNT_uc010ilt.1_Missense_Mutation_p.P329L|NPNT_uc011cff.1_Missense_Mutation_p.P329L|NPNT_uc010ilu.1_Missense_Mutation_p.P225L	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	329	Pro-rich.				cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		CCTACTCCACCACCACCACCA	0.517													14	19					0	0	0.003163	0	0
PAPSS1	9061	broad.mit.edu	37	4	108603283	108603283	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:108603283G>A	uc003hyk.2	-	5	641	c.557C>T	c.(556-558)ACT>ATT	p.T186I	PAPSS1_uc011cfh.1_RNA	NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	186	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		ATCGATCCCAGTGAAACCTGC	0.378													35	57					0	0	0.005524	0	0
SGMS2	166929	broad.mit.edu	37	4	108817049	108817049	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:108817049C>T	uc003hyl.3	+	3	895	c.340C>T	c.(340-342)CCA>TCA	p.P114S	uc003hym.1_Intron|SGMS2_uc003hyn.2_Missense_Mutation_p.P114S|SGMS2_uc003hyo.2_Missense_Mutation_p.P114S	NM_001136258	NP_001129730	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	114					sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			lung(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	CCCTCCACTCCCAGACAAGTT	0.423													15	47					0	0	0.004007	0	0
COL25A1	84570	broad.mit.edu	37	4	109765723	109765723	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:109765723G>A	uc003hze.1	-	29	2112	c.1581C>T	c.(1579-1581)ATC>ATT	p.I527I	COL25A1_uc003hzg.2_Silent_p.I527I|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Silent_p.I285I	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	527	Extracellular (Potential).					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		gtgggcctATGATCTGTATGT	0.279													26	35					0	0	0.006320	0	0
SEC24B	10427	broad.mit.edu	37	4	110447419	110447419	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:110447419C>T	uc003hzk.2	+	17	2884	c.2829C>T	c.(2827-2829)GTC>GTT	p.V943V	SEC24B_uc003hzl.2_Silent_p.V908V|SEC24B_uc011cfp.1_Silent_p.V973V|SEC24B_uc011cfq.1_Silent_p.V942V|SEC24B_uc011cfr.1_Silent_p.V907V	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	943					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		ACTTCTTTGTCCGTTCTACTG	0.353													42	72					0	0	0.002852	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118006361	118006361	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:118006361C>T	uc003ibv.3	-	1	376	c.189G>A	c.(187-189)GAG>GAA	p.E63E		NM_152402	NP_689615	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like	63	Lumenal (Potential).				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)	1						TGGCTTGTTCCTCTGCTGCAG	0.493													12	15					0	0	0.001368	0	0
KIAA1109	84162	broad.mit.edu	37	4	123118412	123118412	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:123118412T>A	uc003ieh.2	+	11	1316	c.1271T>A	c.(1270-1272)ATG>AAG	p.M424K	KIAA1109_uc003iei.1_Missense_Mutation_p.M178K|KIAA1109_uc010ins.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	424					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AATATTCCAATGACAGTTGAA	0.234													20	21					0	0	0.003330	0	0
KIAA1109	84162	broad.mit.edu	37	4	123207824	123207824	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:123207824G>A	uc003ieh.2	+	51	9211	c.9166G>A	c.(9166-9168)GGG>AGG	p.G3056R	KIAA1109_uc003iel.1_Missense_Mutation_p.G991R	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3056					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TACCATGTCAGGGAAATATAT	0.393													31	42					0	0	0.003755	0	0
KIAA1109	84162	broad.mit.edu	37	4	123265596	123265596	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:123265596C>T	uc003ieh.2	+	72	12658	c.12613C>T	c.(12613-12615)CTT>TTT	p.L4205F	KIAA1109_uc003iem.2_Missense_Mutation_p.L561F|KIAA1109_uc003ien.2_Missense_Mutation_p.L139F	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4205					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CAGTATAAACCTTGAGTTTGT	0.413													37	35					0	0	0.004878	0	0
FAT4	79633	broad.mit.edu	37	4	126371308	126371308	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:126371308C>T	uc003ifj.3	+	9	9137	c.9137C>T	c.(9136-9138)TCC>TTC	p.S3046F	FAT4_uc011cgp.1_Missense_Mutation_p.S1344F|FAT4_uc003ifi.1_Missense_Mutation_p.S524F	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3046	Extracellular (Potential).|Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTAGCATCCTCCCTGATTTCT	0.383													11	17					0	0	0.000978	0	0
FAT4	79633	broad.mit.edu	37	4	126371652	126371652	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:126371652G>A	uc003ifj.3	+	9	9481	c.9481G>A	c.(9481-9483)GAA>AAA	p.E3161K	FAT4_uc011cgp.1_Missense_Mutation_p.E1459K|FAT4_uc003ifi.1_Missense_Mutation_p.E639K	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3161	Cadherin 30.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCAGAAACACGAAATGACGAT	0.378													22	31					0	0	0.003954	0	0
FAT4	79633	broad.mit.edu	37	4	126373044	126373044	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:126373044G>A	uc003ifj.3	+	9	10873	c.10873G>A	c.(10873-10875)GGT>AGT	p.G3625S	FAT4_uc011cgp.1_Missense_Mutation_p.G1923S|FAT4_uc003ifi.1_Missense_Mutation_p.G1103S	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3625	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TAATTATTATGGTAACTTGTT	0.443													16	30					0	0	0.004007	0	0
FAT4	79633	broad.mit.edu	37	4	126411747	126411747	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:126411747C>T	uc003ifj.3	+	17	13770	c.13770C>T	c.(13768-13770)TAC>TAT	p.Y4590Y	FAT4_uc011cgp.1_Silent_p.Y2831Y|FAT4_uc003ifi.1_Silent_p.Y2067Y	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4590	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AAAACCCCTACCTTATCTATG	0.473													28	23					0	0	0.006320	0	0
PCDH18	54510	broad.mit.edu	37	4	138442737	138442737	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:138442737C>T	uc003ihe.3	-	4	3241	c.2854G>A	c.(2854-2856)GAA>AAA	p.E952K	PCDH18_uc003ihf.3_Missense_Mutation_p.E944K|PCDH18_uc011cgz.1_Missense_Mutation_p.E163K|PCDH18_uc003ihg.3_Missense_Mutation_p.E731K|PCDH18_uc011cha.1_Missense_Mutation_p.E132K	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	952	Interaction with DAB1 (By similarity).|Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					GGGAATTCTTCCCCTGGAATG	0.532													41	53					0	0	0.007835	0	0
OTUD4	54726	broad.mit.edu	37	4	146067531	146067531	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:146067531G>A	uc003ika.3	-	14	1253	c.1115C>T	c.(1114-1116)TCT>TTT	p.S372F	OTUD4_uc003ijz.3_Missense_Mutation_p.S371F	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	436							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					GAAATAGTTAGATTCTCGACT	0.358													24	31					0	0	0.006320	0	0
LRBA	987	broad.mit.edu	37	4	151749500	151749500	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:151749500G>A	uc010ipj.2	-	30	5477	c.5003C>T	c.(5002-5004)CCG>CTG	p.P1668L	LRBA_uc003ilt.3_Missense_Mutation_p.P327L|LRBA_uc003ilu.3_Missense_Mutation_p.P1668L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1668						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TGAAACTGACGGTGTAGCCTT	0.433													21	29					0	0	0.001882	0	0
PLRG1	5356	broad.mit.edu	37	4	155458438	155458438	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:155458438G>A	uc003iny.2	-	14	1548	c.1485C>T	c.(1483-1485)GCC>GCT	p.A495A	PLRG1_uc003inz.2_Silent_p.A486A	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	495	WD 7.					catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)				CAGAACTTACGGCTGTGTCAT	0.328													13	14					0	0	0.001855	0	0
NPY2R	4887	broad.mit.edu	37	4	156136099	156136099	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:156136099C>T	uc003ioq.2	+	2	1503	c.1008C>T	c.(1006-1008)TTC>TTT	p.F336F	NPY2R_uc003ior.2_Silent_p.F336F	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	336	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				GAAAGGCTTTCCTCTCGGCCT	0.498													24	40					0	0	0.004656	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156698722	156698722	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:156698722C>T	uc003ipc.2	+	4	392	c.225C>T	c.(223-225)TTC>TTT	p.F75F	GUCY1B3_uc011cio.1_Silent_p.F75F|GUCY1B3_uc011cip.1_Silent_p.F55F|GUCY1B3_uc003ipd.2_Silent_p.F3F|GUCY1B3_uc010iqf.2_Silent_p.F75F|GUCY1B3_uc010iqg.2_Silent_p.F3F|GUCY1B3_uc011ciq.1_Silent_p.F3F	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	75					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AGATGTTTTTCGTCTTTTGCC	0.353													32	72					0	0	0.004878	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156725868	156725868	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:156725868G>A	uc003ipc.2	+	12	1845	c.1678G>A	c.(1678-1680)GGA>AGA	p.G560R	GUCY1B3_uc011cio.1_Missense_Mutation_p.G582R|GUCY1B3_uc011cip.1_Missense_Mutation_p.G540R|GUCY1B3_uc003ipd.2_Missense_Mutation_p.G488R|GUCY1B3_uc010iqf.2_Missense_Mutation_p.G527R|GUCY1B3_uc010iqg.2_Missense_Mutation_p.G531R|GUCY1B3_uc011ciq.1_Missense_Mutation_p.G488R	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	560					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AGGAGAAAAGGGAAAAATAAA	0.393													9	14					0	0	0.004482	0	0
NPY5R	4889	broad.mit.edu	37	4	164272606	164272606	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:164272606A>T	uc003iqn.2	+	4	1363	c.1181A>T	c.(1180-1182)AAT>ATT	p.N394I		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	394	Extracellular (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				ACTGATTTTAATGACAATCTT	0.353													23	32					0	0	0.001882	0	0
DDX60	55601	broad.mit.edu	37	4	169196545	169196545	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:169196545C>T	uc003irp.2	-	16	2547	c.2255G>A	c.(2254-2256)AGA>AAA	p.R752K		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	752							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TGGGTCTTTTCTCTCATCTCG	0.378													25	30					0	0	0.003330	0	0
FBXO8	26269	broad.mit.edu	37	4	175184040	175184040	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:175184040G>A	uc003itp.2	-	2	1054	c.204C>T	c.(202-204)TTC>TTT	p.F68F	FBXO8_uc003itq.2_Intron	NM_012180	NP_036312	Q9NRD0	FBX8_HUMAN	F-box only protein 8	68	F-box.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(2)	2		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		CCAAATTAATGAATCCTTCCT	0.418													29	53					0	0	0.007291	0	0
FAT1	2195	broad.mit.edu	37	4	187539895	187539895	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:187539895G>A	uc003izf.2	-	10	8033	c.7845C>T	c.(7843-7845)GTC>GTT	p.V2615V		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2615	Extracellular (Potential).|Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GAACTTTAACGACTGAAGTCC	0.428										HNSCC(5;0.00058)			12	25					0	0	0.002450	0	0
EXOC3	11336	broad.mit.edu	37	5	458137	458137	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:458137C>T	uc003jba.2	+	6	1415	c.1287C>T	c.(1285-1287)TTC>TTT	p.F429F		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	440					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CCATTGTCTTCCAGGTACCAC	0.537													7	13					0	0	0.004482	0	0
IRX2	153572	broad.mit.edu	37	5	2749113	2749113	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:2749113C>T	uc003jda.2	-	3	951	c.709G>A	c.(709-711)GAC>AAC	p.D237N	IRX2_uc003jdb.2_Missense_Mutation_p.D237N	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	237						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		TTCTCCCCGTCCGACTCGGCC	0.692													13	24					0	0	0.003163	0	0
SEMA5A	9037	broad.mit.edu	37	5	9122771	9122771	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:9122771G>T	uc003jek.2	-	14	2490	c.1778C>A	c.(1777-1779)TCC>TAC	p.S593Y		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	593	Extracellular (Potential).|TSP type-1 1.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GGCACACCTGGAACAGTTGGC	0.567													16	52					1.02788e-11	1.56514e-11	0.004990	1	0
CCT5	22948	broad.mit.edu	37	5	10263337	10263337	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:10263337C>T	uc003jeq.2	+	10	1580	c.1409C>T	c.(1408-1410)CCC>CTC	p.P470L	CCT5_uc003jer.2_Missense_Mutation_p.P470L|CCT5_uc010its.2_Intron|CCT5_uc011cmr.1_Missense_Mutation_p.P415L|CCT5_uc011cms.1_Missense_Mutation_p.P432L|CCT5_uc011cmt.1_Missense_Mutation_p.P377L	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	470					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						GGCATGAATCCCATCCAGACT	0.547													25	69					0	0	0.003330	0	0
CTNND2	1501	broad.mit.edu	37	5	10973618	10973618	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:10973618C>T	uc003jfa.1	-	22	3770	c.3625G>A	c.(3625-3627)GAA>AAA	p.E1209K	CTNND2_uc010itt.2_Missense_Mutation_p.E1118K|CTNND2_uc011cmy.1_Missense_Mutation_p.E872K|CTNND2_uc011cmz.1_Missense_Mutation_p.E776K|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.E801K	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1209					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TAGTTCAGTTCACTGTAGGGA	0.612													18	53					0	0	0.007413	0	0
DNAH5	1767	broad.mit.edu	37	5	13716662	13716662	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:13716662G>A	uc003jfd.2	-	74	12885	c.12843C>T	c.(12841-12843)TTC>TTT	p.F4281F	DNAH5_uc003jfc.2_Silent_p.F449F	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4281					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGTAAAAACTGAAATCTGGTC	0.358									Kartagener_syndrome				17	62					0	0	0.006122	0	0
MARCH11	441061	broad.mit.edu	37	5	16091132	16091132	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:16091132C>T	uc003jfo.2	-	3	965	c.752G>A	c.(751-753)GGA>GAA	p.G251E	MARCH11_uc010itw.1_Missense_Mutation_p.G7E	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	251	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						GAACAGGGATCCTAGGATTAC	0.443													13	9					0	0	0.001368	0	0
CDH6	1004	broad.mit.edu	37	5	31305295	31305295	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:31305295A>G	uc003jhe.1	+	7	1340	c.1014A>G	c.(1012-1014)GAA>GAG	p.E338E	CDH6_uc003jhd.1_Silent_p.E338E	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	338	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TGGACTTTGAAAAGAAGAAAG	0.433													23	87					0	0	0.003954	0	0
PDZD2	23037	broad.mit.edu	37	5	31983414	31983414	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:31983414G>A	uc003jhl.2	+	3	1018	c.630G>A	c.(628-630)GCG>GCA	p.A210A	PDZD2_uc003jhm.2_Silent_p.A210A|PDZD2_uc011cnx.1_Silent_p.A36A	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	210					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus		p.A210V(1)		central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						ACCGAACTGCGAAAAAGGGGA	0.537													20	63					0	0	0.002299	0	0
PDZD2	23037	broad.mit.edu	37	5	32000310	32000310	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:32000310C>T	uc003jhl.2	+	5	1575	c.1187C>T	c.(1186-1188)TCC>TTC	p.S396F	PDZD2_uc003jhm.2_Missense_Mutation_p.S396F|PDZD2_uc011cnx.1_Missense_Mutation_p.S222F	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	396	PDZ 2.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GTCGGGCTCTCCCACGAGGAA	0.532													45	29					0	0	0.003610	0	0
AGXT2	64902	broad.mit.edu	37	5	35010218	35010218	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35010218C>T	uc003jjf.2	-	12	1304	c.1225G>A	c.(1225-1227)GAA>AAA	p.E409K	AGXT2_uc003jje.1_Missense_Mutation_p.E62K|AGXT2_uc011com.1_Missense_Mutation_p.E334K	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	409					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GTCCCAACTTCTTGACTGTTT	0.398													50	56					0	0	0.003610	0	0
IL7R	3575	broad.mit.edu	37	5	35875626	35875626	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35875626C>T	uc003jjs.2	+	7	902	c.813C>T	c.(811-813)ATC>ATT	p.I271I	IL7R_uc011coo.1_Missense_Mutation_p.S240L|IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	271	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TTAAGCCTATCGTATGGCCCA	0.398													43	15					0	0	0.002222	0	0
IL7R	3575	broad.mit.edu	37	5	35876118	35876118	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35876118C>T	uc003jjs.2	+	8	999	c.910C>T	c.(910-912)CTG>TTG	p.L304L	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	304	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TGAAAGTTTCCTGGACTGCCA	0.408													16	39					0	0	0.004007	0	0
IL7R	3575	broad.mit.edu	37	5	35876163	35876163	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35876163G>A	uc003jjs.2	+	8	1044	c.955G>A	c.(955-957)GAA>AAA	p.E319K	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	319	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AGCTAGAGATGAAGTGGAAGG	0.453													13	42					0	0	0.001368	0	0
IL7R	3575	broad.mit.edu	37	5	35876214	35876214	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35876214G>A	uc003jjs.2	+	8	1095	c.1006G>A	c.(1006-1008)GAG>AAG	p.E336K	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	336	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AGAAGAATCTGAGAAGCAGAG	0.478													14	40					0	0	0.004007	0	0
IL7R	3575	broad.mit.edu	37	5	35876216	35876216	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35876216G>A	uc003jjs.2	+	8	1097	c.1008G>A	c.(1006-1008)GAG>GAA	p.E336E	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	336	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AAGAATCTGAGAAGCAGAGGC	0.488													14	41					0	0	0.004990	0	0
RICTOR	253260	broad.mit.edu	37	5	38954908	38954908	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:38954908G>A	uc003jlp.2	-	27	2689	c.2665C>T	c.(2665-2667)CAT>TAT	p.H889Y	RICTOR_uc003jlo.2_Missense_Mutation_p.H889Y|RICTOR_uc010ivf.2_Missense_Mutation_p.H604Y	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	889					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					CCTGTTTTATGGTGTACTAGT	0.313													35	67					0	0	0.006230	0	0
C7	730	broad.mit.edu	37	5	40945459	40945459	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:40945459C>T	uc003jmh.2	+	7	841	c.727C>T	c.(727-729)CAT>TAT	p.H243Y	C7_uc011cpn.1_Intron	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	243	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				CAATGAAATCCATAAAGGAAA	0.323													20	47					0	0	0.002299	0	0
C7	730	broad.mit.edu	37	5	40955588	40955588	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:40955588G>A	uc003jmh.2	+	10	1307	c.1193G>A	c.(1192-1194)GGA>GAA	p.G398E	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	398	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				AATCCTGCTGGAAACAAAAGG	0.458													97	49					0	0	0.003610	0	0
C5orf34	375444	broad.mit.edu	37	5	43502496	43502496	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:43502496G>A	uc003jnz.1	-	7	1447	c.1130C>T	c.(1129-1131)TCT>TTT	p.S377F		NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	377										breast(1)	1	Lung NSC(6;2.07e-05)					TTCTTGAATAGAATAATAAGT	0.328													35	82					0	0	0.004289	0	0
PARP8	79668	broad.mit.edu	37	5	50118184	50118184	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:50118184C>T	uc003jon.3	+	18	1992	c.1810C>T	c.(1810-1812)CGA>TGA	p.R604*	PARP8_uc011cpz.1_Nonsense_Mutation_p.R496*|PARP8_uc003joo.2_Nonsense_Mutation_p.R604*|PARP8_uc003jop.2_Nonsense_Mutation_p.R562*	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	604						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GAACTATGATCGAGTAATGAA	0.303													48	112					0	0	0.003610	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54696093	54696093	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:54696093C>T	uc003jpy.3	+	21	2591	c.2325C>T	c.(2323-2325)CCC>CCT	p.P775P	SKIV2L2_uc011cqi.1_Silent_p.P674P	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	775					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				ACGGCATCCCCTTATTAGACC	0.353													11	47					0	0	0.001368	0	0
PDE4D	5144	broad.mit.edu	37	5	58511729	58511729	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:58511729G>A	uc003jsa.2	-	2	693	c.521C>T	c.(520-522)TCC>TTC	p.S174F	PDE4D_uc003jrx.2_Missense_Mutation_p.S38F|PDE4D_uc003jry.2_5'UTR|PDE4D_uc003jrz.2_Missense_Mutation_p.S110F|PDE4D_uc003jsb.2_Missense_Mutation_p.S113F|PDE4D_uc003jsc.2_Missense_Mutation_p.S110F|PDE4D_uc003jrv.2_Missense_Mutation_p.S44F|PDE4D_uc003jrw.2_Missense_Mutation_p.S52F|PDE4D_uc010iwi.1_Missense_Mutation_p.S6F	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	174					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	AATTAGCCCGGATCCTGGGCT	0.498													8	30					0	0	0.003080	0	0
IPO11	51194	broad.mit.edu	37	5	61779894	61779894	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:61779894C>T	uc003jtc.2	+	11	1269	c.1079C>T	c.(1078-1080)CCT>CTT	p.P360L	IPO11_uc011cqr.1_Missense_Mutation_p.P400L|IPO11_uc003jtb.1_Missense_Mutation_p.P360L	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	360						cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		TTCACATATCCTACTTTGACA	0.353													19	61					0	0	0.001523	0	0
RGS7BP	401190	broad.mit.edu	37	5	63905011	63905011	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:63905011A>G	uc003jtj.2	+	6	706	c.706A>G	c.(706-708)ACT>GCT	p.T236A	RGS7BP_uc011cqu.1_Missense_Mutation_p.T103A	NM_001029875	NP_001025046	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding	236					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane					0		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		TCTGAATCTAACTCCCTACCC	0.468													31	25					0	0	0.004289	0	0
TMEM171	134285	broad.mit.edu	37	5	72419681	72419681	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:72419681C>T	uc003kcm.2	+	2	685	c.481C>T	c.(481-483)CTT>TTT	p.L161F	TMEM171_uc003kcn.3_Missense_Mutation_p.L161F	NM_173490	NP_775761	Q8WVE6	TM171_HUMAN	transmembrane protein 171 isoform 1	161	Helical; (Potential).					integral to membrane					0		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		GTGTGGGTTCCTTTCTCTGCA	0.557													71	74					0	0	0.003610	0	0
RGNEF	64283	broad.mit.edu	37	5	73045673	73045673	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:73045673G>A	uc011csq.1	+	2	56	c.45G>A	c.(43-45)ATG>ATA	p.M15I	RGNEF_uc003kcx.2_Missense_Mutation_p.M15I|RGNEF_uc003kcy.1_Missense_Mutation_p.M15I|RGNEF_uc010izf.2_Missense_Mutation_p.M15I	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	15					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		GGCAGATGATGATCTATGCGA	0.433													20	82					0	0	0.001882	0	0
SV2C	22987	broad.mit.edu	37	5	75428043	75428043	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:75428043C>T	uc003kei.1	+	2	602	c.468C>T	c.(466-468)TTC>TTT	p.F156F		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	156	Helical; (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CCCTTTTCTTCGTCCTGGGCA	0.507													59	72					0	0	0.003610	0	0
JMY	133746	broad.mit.edu	37	5	78610468	78610468	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:78610468C>T	uc003kfx.3	+	9	2973	c.2453C>T	c.(2452-2454)CCC>CTC	p.P818L	JMY_uc003kfw.1_Missense_Mutation_p.P464L	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	818	Pro-rich.				'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		ccacctcctccccctccccca	0.353													25	14					0	0	0.004656	0	0
VCAN	1462	broad.mit.edu	37	5	82834173	82834173	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:82834173G>A	uc003kii.3	+	8	5707	c.5351G>A	c.(5350-5352)AGG>AAG	p.R1784K	VCAN_uc003kij.3_Missense_Mutation_p.R797K|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.R448K	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1784	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGTCTGAAAGGGAAATGACA	0.398													18	91					0	0	0.008871	0	0
ARSK	153642	broad.mit.edu	37	5	94936653	94936653	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:94936653C>T	uc003kld.2	+	7	1357	c.1199C>T	c.(1198-1200)CCA>CTA	p.P400L	ARSK_uc010jbg.2_Missense_Mutation_p.P241L|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	400						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		AACCTGCATCCACCCTGGATT	0.418													76	118					0	0	0.003610	0	0
YTHDC2	64848	broad.mit.edu	37	5	112915296	112915296	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:112915296C>T	uc003kqn.2	+	24	3441	c.3258C>T	c.(3256-3258)CCC>CCT	p.P1086P		NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1086							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		ATGGCATTCCCAATGACAGTA	0.378													45	222					0	0	0.003610	0	0
HSD17B4	3295	broad.mit.edu	37	5	118844910	118844910	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:118844910G>A	uc003ksj.2	+	16	1531	c.1408G>A	c.(1408-1410)GGT>AGT	p.G470S	HSD17B4_uc011cwg.1_Missense_Mutation_p.G446S|HSD17B4_uc011cwh.1_Missense_Mutation_p.G452S|HSD17B4_uc011cwi.1_Missense_Mutation_p.G495S|HSD17B4_uc003ksk.3_Missense_Mutation_p.G323S|HSD17B4_uc011cwj.1_Missense_Mutation_p.G323S|HSD17B4_uc010jcn.1_Missense_Mutation_p.G208S	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	470	Enoyl-CoA hydratase 2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	TGGAGGCTTTGGTGGAAAACG	0.318													35	147					0	0	0.008740	0	0
PPIC	5480	broad.mit.edu	37	5	122361629	122361629	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:122361629C>T	uc003kth.2	-	4	465	c.360G>A	c.(358-360)GAG>GAA	p.E120E		NM_000943	NP_000934	P45877	PPIC_HUMAN	peptidylprolyl isomerase C	120	PPIase cyclophilin-type.				protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			ovary(1)	1		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	GCTTGAAGTTCTCATCTGGAA	0.473													4	36					0	0	0.000248	0	0
ALDH7A1	501	broad.mit.edu	37	5	125919695	125919695	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:125919695G>A	uc003ktx.2	-	4	514	c.322C>T	c.(322-324)CCA>TCA	p.P108S	ALDH7A1_uc003kty.2_RNA|ALDH7A1_uc011cxa.1_Missense_Mutation_p.P135S|ALDH7A1_uc003ktz.2_Missense_Mutation_p.P135S	NM_001182	NP_001173	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	108					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			kidney(2)|ovary(1)	3		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	CCTCGTTTTGGAGCAGGAATC	0.348													29	99					0	0	0.002096	0	0
FBN2	2201	broad.mit.edu	37	5	127640745	127640745	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:127640745C>T	uc003kuu.2	-	45	6143	c.5704G>A	c.(5704-5706)GTT>ATT	p.V1902I		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1902	EGF-like 31; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGACTGCAAACGTTAGGAATT	0.368													12	36					0	0	0.001855	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129037197	129037197	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:129037197G>A	uc003kvb.1	+	20	3053	c.3053G>A	c.(3052-3054)AGG>AAG	p.R1018K	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1018	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GCCCGAGAGAGGGACTGCATT	0.582													16	79					0	0	0.008871	0	0
ACSL6	23305	broad.mit.edu	37	5	131309017	131309017	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:131309017G>A	uc010jdo.1	-	12	1153	c.1070C>T	c.(1069-1071)GCT>GTT	p.A357V	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.A382V|ACSL6_uc003kvy.1_Missense_Mutation_p.A382V|ACSL6_uc003kwb.2_Missense_Mutation_p.A347V|ACSL6_uc003kvz.1_Missense_Mutation_p.A282V|ACSL6_uc003kwa.1_Missense_Mutation_p.A368V|ACSL6_uc003kvw.1_Missense_Mutation_p.A3V|ACSL6_uc010jdn.1_Missense_Mutation_p.A372V|ACSL6_uc010jdp.1_RNA	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	357	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGGGCATAGAGCCTTCATGTC	0.557													24	75					0	0	0.004656	0	0
CAMLG	819	broad.mit.edu	37	5	134076819	134076819	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:134076819C>T	uc003kzt.2	+	2	344	c.239C>T	c.(238-240)TCC>TTC	p.S80F	CAMLG_uc003kzu.2_Intron	NM_001745	NP_001736	P49069	CAMLG_HUMAN	calcium modulating ligand	80	Cytoplasmic (Potential).				defense response	endoplasmic reticulum|integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	AGCGTTCCTTCCGTTTCAAAG	0.453													36	54					0	0	0.005524	0	0
TGFBI	7045	broad.mit.edu	37	5	135389719	135389719	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:135389719C>T	uc003lbf.3	+	9	1375	c.1214C>T	c.(1213-1215)TCT>TTT	p.S405F	TGFBI_uc003lbg.3_Missense_Mutation_p.S138F|TGFBI_uc003lbh.3_Missense_Mutation_p.S231F|TGFBI_uc011cyb.1_Missense_Mutation_p.S231F|TGFBI_uc010jed.2_Missense_Mutation_p.S138F	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	405	FAS1 3.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AATCATCTCTCTGGAAGTGAG	0.517													73	87					0	0	0.003610	0	0
WNT8A	7478	broad.mit.edu	37	5	137426466	137426466	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:137426466G>A	uc003lcd.1	+	6	765	c.760G>A	c.(760-762)GAA>AAA	p.E254K	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_Missense_Mutation_p.E272K|WNT8A_uc011cyk.1_Missense_Mutation_p.E272K	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	254					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTTTTTAGAGGAATCACCAGA	0.582													37	56					0	0	0.006999	0	0
EGR1	1958	broad.mit.edu	37	5	137803292	137803293	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:137803292_137803293CC>TT	uc003ldb.1	+	2	1424_1425	c.1154_1155CC>TT	c.(1153-1155)ACC>ATT	p.T385I	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	385	C2H2-type 2.				cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CACCTCACCACCCACATCCGCA	0.599													11	58					0	0	0.004672	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202124	140202124	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140202124C>T	uc003lhl.2	+	1	764	c.764C>T	c.(763-765)CCA>CTA	p.P255L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.P255L|PCDHA5_uc003lhj.1_Missense_Mutation_p.P255L	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	255	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAATGCACCAAGTGGGACA	0.358													16	87					0	0	0.004007	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208798	140208798	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140208798G>A	uc003lho.2	+	1	1149	c.1122G>A	c.(1120-1122)GTG>GTA	p.V374V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.V374V|PCDHA6_uc011dab.1_Silent_p.V374V	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	374	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAATTAGCGTGAACGACCTCG	0.498													81	111					0	0	0.003610	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256034	140256034	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140256034G>A	uc003lic.2	+	1	1104	c.977G>A	c.(976-978)GGG>GAG	p.G326E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.G326E	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	326	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGATAAAGGGATTCCTTCC	0.418													48	65					0	0	0.003610	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263218	140263218	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140263218C>T	uc003lif.2	+	1	1365	c.1365C>T	c.(1363-1365)TTC>TTT	p.F455F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.F455F|PCDHA13_uc003lid.2_Silent_p.F455F	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	455	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCGGCGTTCGCGCAGCCCG	0.682													19	91					0	0	0.008871	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501932	140501932	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140501932G>A	uc003lip.1	+	1	352	c.352G>A	c.(352-354)GGA>AGA	p.G118R		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	118	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATTTTTTCAAGGAGAATTATT	0.433													16	66					0	0	0.004990	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563511	140563511	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140563511C>T	uc003liv.2	+	1	2532	c.1377C>T	c.(1375-1377)TTC>TTT	p.F459F	PCDHB16_uc010jfw.1_Silent_p.F131F	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	459	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.582													61	112					0	0	0.003610	0	0
PCDHB9	56127	broad.mit.edu	37	5	140567497	140567497	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140567497G>A	uc003liw.1	+	1	605	c.605G>A	c.(604-606)CGG>CAG	p.R202Q		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	202	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACTGGATCGGGAGGAGCAG	0.488													94	138					0	0	0.003610	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589305	140589305	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140589305G>A	uc003liz.2	+	1	1015	c.826G>A	c.(826-828)GAA>AAA	p.E276K	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	276	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACAAACAGTGAACTATCCTA	0.418													80	119					0	0	0.003610	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755006	140755006	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140755006C>T	uc003ljy.1	+	1	1356	c.1356C>T	c.(1354-1356)TTC>TTT	p.F452F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.F452F	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	452	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCCACCTTCCCCCATTCAT	0.527													90	107					0	0	0.003610	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140789035	140789035	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140789035C>T	uc003lkj.1	+	1	1266	c.1266C>T	c.(1264-1266)ATC>ATT	p.I422I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.I422I	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	422	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTCACCATCGTAGCCACTG	0.483													35	45					0	0	0.004289	0	0
HDAC3	8841	broad.mit.edu	37	5	141009682	141009682	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:141009682G>A	uc003llf.2	-	4	358	c.292C>T	c.(292-294)CCC>TCC	p.P98S	HDAC3_uc003lle.1_Missense_Mutation_p.P41S|HDAC3_uc010jgd.1_Intron|HDAC3_uc010jge.1_Intron	NM_003883	NP_003874	O15379	HDAC3_HUMAN	histone deacetylase 3	98	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	AAGAGCCCGGGAAACACTGGG	0.557													67	63					0	0	0.003610	0	0
PCDH12	51294	broad.mit.edu	37	5	141335404	141335404	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:141335404C>T	uc003llx.2	-	1	3224	c.2013G>A	c.(2011-2013)TGG>TGA	p.W671*		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	671	Cadherin 6.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTCCAGCTCCCACTCACTCC	0.567													16	23					0	0	0.004990	0	0
LARS	51520	broad.mit.edu	37	5	145500056	145500056	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:145500056G>A	uc003lnx.1	-	31	3441	c.3203C>T	c.(3202-3204)TCC>TTC	p.S1068F	LARS_uc003lnw.1_Missense_Mutation_p.S226F|LARS_uc011dbq.1_Missense_Mutation_p.S1022F|LARS_uc011dbr.1_Missense_Mutation_p.S1014F|LARS_uc011dbs.1_Missense_Mutation_p.S1041F	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	1068					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CAGAGAAACGGACACACCAGG	0.428													39	48					0	0	0.007835	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147010991	147010991	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:147010991C>T	uc003loq.1	-	14	2242	c.1860G>A	c.(1858-1860)ATG>ATA	p.M620I	JAKMIP2_uc011dbx.1_Missense_Mutation_p.M578I|JAKMIP2_uc003lor.1_Missense_Mutation_p.M599I|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Missense_Mutation_p.M620I	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	620						Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCTTCTTTCATACAGTAGA	0.383													23	29					0	0	0.005443	0	0
SCGB3A2	117156	broad.mit.edu	37	5	147258400	147258400	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:147258400A>G	uc003lot.1	+	1	127	c.34A>G	c.(34-36)ATC>GTC	p.I12V		NM_054023	NP_473364	Q96PL1	SG3A2_HUMAN	secretoglobin, family 3A, member 2 precursor	12						extracellular region	binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGTGACCATCAGCCTTTG	0.373													79	103					0	0	0.003610	0	0
SPINK5	11005	broad.mit.edu	37	5	147470749	147470749	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:147470749C>T	uc003lox.2	+	8	697	c.624C>T	c.(622-624)GCC>GCT	p.A208A	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Silent_p.A180A|SPINK5_uc010jgr.2_Silent_p.A189A|SPINK5_uc003low.2_Silent_p.A208A|SPINK5_uc003loy.2_Silent_p.A208A	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	208	Kazal-like 3.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAAAATGCCAAGCGAGAGG	0.348													5	12					0	0	0.000602	0	0
GRPEL2	134266	broad.mit.edu	37	5	148727857	148727858	+	Missense_Mutation	DNP	AC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:148727857_148727858AC>TT	uc003lqj.2	+	2	226_227	c.100_101AC>TT	c.(100-102)ACT>TTT	p.T34F	GRPEL2_uc011dca.1_Missense_Mutation_p.T34F	NM_152407	NP_689620	Q8TAA5	GRPE2_HUMAN	GrpE-like 2, mitochondrial precursor	34					protein folding	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCATTCAGCACTGCCACCCAG	0.51													56	73					0	0	0.004672	0	0
ARHGEF37	389337	broad.mit.edu	37	5	149001562	149001562	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149001562C>T	uc003lra.1	+	9	1336	c.1272C>T	c.(1270-1272)TTC>TTT	p.F424F		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	424	BAR.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						TGTGCACATTCGTGACCCTCC	0.587													15	19					0	0	0.002450	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149212591	149212591	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149212591C>T	uc003lrc.2	+	5	997	c.955C>T	c.(955-957)CCC>TCC	p.P319S	PPARGC1B_uc003lrb.1_Missense_Mutation_p.P319S|PPARGC1B_uc003lrd.2_Missense_Mutation_p.P280S|PPARGC1B_uc003lrf.2_Missense_Mutation_p.P298S|PPARGC1B_uc003lre.1_Missense_Mutation_p.P298S	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	319					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CTGCAGCAACCCCTCCCAGCA	0.627													22	41					0	0	0.003330	0	0
PDE6A	5145	broad.mit.edu	37	5	149294570	149294570	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149294570C>T	uc003lrg.3	-	6	1054	c.934G>A	c.(934-936)GAA>AAA	p.E312K		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	312	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AAGTTAATTTCCTGGCAAAAG	0.194													50	58					0	0	0.003610	0	0
CDX1	1044	broad.mit.edu	37	5	149563178	149563178	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149563178C>T	uc003lrq.2	+	3	829	c.733C>T	c.(733-735)CCC>TCC	p.P245S		NM_001804	NP_001795	P47902	CDX1_HUMAN	caudal type homeobox 1	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGCCTGTGTCCCAGCAACAC	0.657													15	19					0	0	0.001523	0	0
CD74	972	broad.mit.edu	37	5	149784691	149784691	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149784691T>C	uc003lsc.2	-	5	505	c.494A>G	c.(493-495)AAC>AGC	p.N165S	CD74_uc003lsb.2_Missense_Mutation_p.N29S|CD74_uc003lse.2_Intron|CD74_uc003lsd.2_Missense_Mutation_p.N165S|CD74_uc003lsf.1_Missense_Mutation_p.N165S	NM_001025159	NP_001020330	P04233	HG2A_HUMAN	CD74 antigen isoform a	165	Extracellular (Potential).				antigen processing and presentation of endogenous antigen|cell proliferation|immunoglobulin mediated immune response|intracellular protein transport|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of peptide secretion|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of cytokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of macrophage cytokine production|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|prostaglandin biosynthetic process|protein complex assembly|regulation of macrophage activation	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|lysosome|receptor complex	beta-amyloid binding|cytokine receptor activity|identical protein binding|MHC class II protein binding			breast(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGTCTCAGGTTCTCCGGGAA	0.567			T	ROS1	NSCLC								60	106					0	0	0.003610	0	0
NDST1	3340	broad.mit.edu	37	5	149900862	149900862	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149900862C>T	uc003lsk.3	+	2	548	c.46C>T	c.(46-48)CCG>TCG	p.P16S	NDST1_uc011dcj.1_Missense_Mutation_p.P16S|NDST1_uc003lsl.2_Missense_Mutation_p.P16S	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	16	Cytoplasmic (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCACGTGTCCCCGCAGGCTGT	0.647													24	58					0	0	0.002299	0	0
C5orf62	85027	broad.mit.edu	37	5	150158501	150158501	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:150158501C>T	uc003lsw.2	+	1	635	c.370C>T	c.(370-372)CCA>TCA	p.P124S		NM_032947	NP_116565	Q9BZL3	NID67_HUMAN	putative small membrane protein NID67	Error:Variant_position_missing_in_Q9BZL3_after_alignment						integral to membrane					0						CATCCCTGACCCAGGAACTTT	0.662													3	9					0	0	0.000248	0	0
SLC36A1	206358	broad.mit.edu	37	5	150838456	150838456	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:150838456C>T	uc003luc.2	+	2	320	c.103C>T	c.(103-105)CCG>TCG	p.P35S	GM2A_uc011dcs.1_Intron|SLC36A1_uc003lub.1_Missense_Mutation_p.P35S|SLC36A1_uc010jhw.1_Missense_Mutation_p.P35S	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	35	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	CCTCTCCTCCCCGGGCTCCTA	0.577													25	62					0	0	0.005443	0	0
SLC36A1	206358	broad.mit.edu	37	5	150853240	150853240	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:150853240C>T	uc003luc.2	+	8	947	c.730C>T	c.(730-732)CCA>TCA	p.P244S	GM2A_uc011dcs.1_Intron|SLC36A1_uc003lub.1_Missense_Mutation_p.P244S|SLC36A1_uc010jhw.1_Missense_Mutation_p.P244S	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	244	Extracellular (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	TCAGAGGATCCCAGACCCCAG	0.408													125	178					0	0	0.003610	0	0
FAT2	2196	broad.mit.edu	37	5	150946847	150946847	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:150946847G>A	uc003lue.3	-	1	1659	c.1646C>T	c.(1645-1647)TCC>TTC	p.S549F	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.S549F	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	549	Cadherin 4.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGAAAAATGGACACTTCCTT	0.473													23	124					0	0	0.003954	0	0
GRIA1	2890	broad.mit.edu	37	5	153175112	153175112	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:153175112G>A	uc003lva.3	+	14	2712	c.2347G>A	c.(2347-2349)GAT>AAT	p.D783N	GRIA1_uc003luy.3_Intron|GRIA1_uc003luz.3_Missense_Mutation_p.D688N|GRIA1_uc011dcv.1_Intron|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Intron|GRIA1_uc011dcy.1_Missense_Mutation_p.D793N|GRIA1_uc011dcz.1_Intron	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	783	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ATGGTGGTACGATAAAGGGGA	0.483													17	22					0	0	0.007413	0	0
CYFIP2	26999	broad.mit.edu	37	5	156757855	156757855	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:156757855C>T	uc003lwq.2	+	22	2400	c.2262C>T	c.(2260-2262)GTC>GTT	p.V754V	CYFIP2_uc011ddn.1_Silent_p.V728V|CYFIP2_uc011ddo.1_Silent_p.V558V|CYFIP2_uc003lwr.2_Silent_p.V754V|CYFIP2_uc003lws.2_Silent_p.V754V|CYFIP2_uc003lwt.2_Silent_p.V657V|CYFIP2_uc011ddp.1_Silent_p.V488V	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	779					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGAGACACGTCCAGGTATGGG	0.498													60	251					0	0	0.003610	0	0
CCNJL	79616	broad.mit.edu	37	5	159680613	159680613	+	Silent	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:159680613G>T	uc003lyb.1	-	7	1332	c.1080C>A	c.(1078-1080)TCC>TCA	p.S360S	CCNJL_uc011dee.1_Silent_p.S312S|CCNJL_uc003lyc.1_RNA	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	360						nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGCCTGCAAGGAGTCCCGAT	0.657													19	61					8.04996e-18	1.22966e-17	0.001882	1	0
GABRB2	2561	broad.mit.edu	37	5	160721399	160721399	+	Missense_Mutation	SNP	C	T	T	rs148772321		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:160721399C>T	uc003lys.1	-	11	1446	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	GABRB2_uc011deh.1_Missense_Mutation_p.E211K|GABRB2_uc003lyr.1_Missense_Mutation_p.E372K|GABRB2_uc003lyt.1_Missense_Mutation_p.E372K|GABRB2_uc010jiu.1_Missense_Mutation_p.E309K	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	410	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTTTTTATCTCGAGAGTGCTC	0.463													44	74					0	0	0.003610	0	0
GABRG2	2566	broad.mit.edu	37	5	161580318	161580318	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:161580318C>T	uc003lyz.3	+	9	1706	c.1348C>T	c.(1348-1350)CCC>TCC	p.P450S	GABRG2_uc010jjc.2_Missense_Mutation_p.P498S|GABRG2_uc003lyy.3_Missense_Mutation_p.P458S|GABRG2_uc011dej.1_Missense_Mutation_p.P355S	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	450	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GATCTTCTTCCCCACTGCCTT	0.453													100	155					0	0	0.003610	0	0
PANK3	79646	broad.mit.edu	37	5	167995999	167995999	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:167995999G>A	uc003lzz.1	-	2	333	c.33C>T	c.(31-33)TTC>TTT	p.F11F		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	11					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		CAAACCATGGGAAAGCTATGG	0.328													10	51					0	0	0.006214	0	0
KCNMB1	3779	broad.mit.edu	37	5	169810805	169810806	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:169810805_169810806CC>TT	uc003maq.1	-	3	583_584	c.183_184GG>AA	c.(181-186)AGGGAC>AGAAAC	p.D62N	KCNIP1_uc003map.2_Intron|KCNMB1_uc003mar.2_Missense_Mutation_p.D62N	NM_004137	NP_004128	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated	62	Extracellular (Potential).				platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			ovary(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		TCCTCCTGGTCCCTGATGTTGG	0.579													20	28					0	0	0.004672	0	0
HMP19	51617	broad.mit.edu	37	5	173531337	173531337	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:173531337A>T	uc003mcx.2	+	4	465	c.320A>T	c.(319-321)TAT>TTT	p.Y107F	HMP19_uc011dfh.1_Missense_Mutation_p.I11L	NM_015980	NP_057064	Q9Y328	NSG2_HUMAN	HMP19 protein	107	Lumenal (Potential).				dopamine receptor signaling pathway	cytoplasmic vesicle membrane|Golgi cisterna membrane|integral to membrane|multivesicular body membrane	dopamine receptor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00925)|all_lung(126;0.0148)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GGATTCGTCTATAAGGTAAGA	0.478													13	46					0	0	0.004007	0	0
SLC34A1	6569	broad.mit.edu	37	5	176812796	176812796	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:176812796C>T	uc003mgk.3	+	2	155	c.54C>T	c.(52-54)GTC>GTT	p.V18V		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	18	Cytoplasmic (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACTCCCAGTCCGTGGGGGGC	0.647													29	26					0	0	0.002096	0	0
B4GALT7	11285	broad.mit.edu	37	5	177031345	177031345	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:177031345C>T	uc003mhy.2	+	2	256	c.216C>T	c.(214-216)CCC>CCT	p.P72P	B4GALT7_uc003mhz.2_5'UTR	NM_007255	NP_009186	Q9UBV7	B4GT7_HUMAN	xylosylprotein beta 1,4-galactosyltransferase 7	72	Lumenal (Potential).				fibril organization|glycosaminoglycan biosynthetic process|negative regulation of fibroblast proliferation|protein modification process|proteoglycan metabolic process	Golgi cisterna membrane|integral to membrane	metal ion binding|xylosylprotein 4-beta-galactosyltransferase activity			pancreas(1)	1	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGGCCCTCCCCGTGCCTGCC	0.701													4	6					0	0	0.000248	0	0
COL23A1	91522	broad.mit.edu	37	5	177683400	177683400	+	Splice_Site	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:177683400T>G	uc003mje.2	-	15	1196	c.838_splice	c.e15-1	p.G280_splice	COL23A1_uc010jkt.2_Splice_Site_p.R127_splice	NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1							collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		AGGCTCCCCCTGTGGAGACAT	0.672													13	19					0	0	0.006122	0	0
ZNF454	285676	broad.mit.edu	37	5	178392003	178392003	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:178392003C>T	uc003mjo.1	+	5	869	c.598C>T	c.(598-600)CAT>TAT	p.H200Y	ZNF454_uc010jkz.1_Missense_Mutation_p.H200Y	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	200	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		TCAGAAAATTCATAATGAAAA	0.343													27	39					0	0	0.005443	0	0
OR2V2	285659	broad.mit.edu	37	5	180582833	180582833	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:180582833G>A	uc011dhj.1	+	1	891	c.891G>A	c.(889-891)GAG>GAA	p.E297E		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGAACAGGGAGGTGATGGGGG	0.532													13	39					0	0	0.004007	0	0
SERPINB9	5272	broad.mit.edu	37	6	2890624	2890624	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:2890624C>T	uc003mug.2	-	7	1025	c.904G>A	c.(904-906)GCA>ACA	p.A302T	uc003mue.2_Intron|SERPINB9_uc003muf.2_Missense_Mutation_p.A105T	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	302					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				GCTGACATTGCCGACAAGTCA	0.502													26	157					0	0	0.004656	0	0
CAGE1	285782	broad.mit.edu	37	6	7374037	7374037	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7374037C>T	uc003mxi.2	-	4	1328	c.607G>A	c.(607-609)GAA>AAA	p.E203K	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Missense_Mutation_p.E94K|CAGE1_uc003mxk.1_Missense_Mutation_p.E94K	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	339	Potential.										0	Ovarian(93;0.0418)					ATCTGTAGTTCTTTAACCCTC	0.328													18	82					0	0	0.007413	0	0
DSP	1832	broad.mit.edu	37	6	7579632	7579632	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7579632C>T	uc003mxp.1	+	23	3488	c.3209C>T	c.(3208-3210)TCC>TTC	p.S1070F	DSP_uc003mxq.1_Missense_Mutation_p.S1070F	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1070	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCAGAGTGTTCCCAGTTCAAA	0.507													24	100					0	0	0.003954	0	0
DSP	1832	broad.mit.edu	37	6	7580387	7580387	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7580387G>A	uc003mxp.1	+	23	4243	c.3964G>A	c.(3964-3966)GAC>AAC	p.D1322N	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1322	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GACCATTCAGGACAAAAATAA	0.502													21	120					0	0	0.001882	0	0
DSP	1832	broad.mit.edu	37	6	7581101	7581101	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7581101C>T	uc003mxp.1	+	23	4957	c.4678C>T	c.(4678-4680)CAG>TAG	p.Q1560*	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1560	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CACGCGGTTCCAGAACTCTCT	0.527													28	158					0	0	0.005443	0	0
DSP	1832	broad.mit.edu	37	6	7584736	7584736	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7584736G>T	uc003mxp.1	+	24	7520	c.7241G>T	c.(7240-7242)GGA>GTA	p.G2414V	DSP_uc003mxq.1_Missense_Mutation_p.G1815V	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2414	Plectin 11.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GATACCAAAGGATTTTTTGAC	0.408													35	134					1.06647e-15	1.6276e-15	0.003755	1	0
DSP	1832	broad.mit.edu	37	6	7585215	7585215	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7585215G>C	uc003mxp.1	+	24	7999	c.7720G>C	c.(7720-7722)GGC>CGC	p.G2574R	DSP_uc003mxq.1_Missense_Mutation_p.G1975R	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2574	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CAGCAGCATGGGCAGTGGTGT	0.483													21	134					0	0	0.001882	0	0
DSP	1832	broad.mit.edu	37	6	7585916	7585916	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7585916C>T	uc003mxp.1	+	24	8700	c.8421C>T	c.(8419-8421)TCC>TCT	p.S2807S	DSP_uc003mxq.1_Silent_p.S2208S	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2807	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAGCCGCCTCCGTGTCGTCCA	0.393													43	265					0	0	0.003610	0	0
PIP5K1P1	206426	broad.mit.edu	37	6	7987565	7987565	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7987565C>T	uc003mxx.3	+	1	1231	c.796C>T	c.(796-798)CCC>TCC	p.P266S	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						GAAGCCTCTTCCCACATTTAA	0.448													14	53					0	0	0.002450	0	0
GCM2	9247	broad.mit.edu	37	6	10874655	10874655	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:10874655G>A	uc003mzn.3	-	5	1166	c.1094C>T	c.(1093-1095)CCC>CTC	p.P365L	SYCP2L_uc011dim.1_Intron	NM_004752	NP_004743	O75603	GCM2_HUMAN	glial cells missing homolog 2	365					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				GTACCTGCAGGGAAGCTCTGG	0.572													45	276					0	0	0.003610	0	0
ATXN1	6310	broad.mit.edu	37	6	16328174	16328174	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:16328174A>C	uc003nbt.2	-	8	1339	c.368T>G	c.(367-369)CTG>CGG	p.L123R	ATXN1_uc010jpi.2_Missense_Mutation_p.L123R|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	123					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GGTGTGCGGCAGGTGAGCGTA	0.667													14	110					0	0	0.002450	0	0
RBM24	221662	broad.mit.edu	37	6	17292259	17292259	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:17292259G>A	uc003nbz.3	+	4	624	c.620G>A	c.(619-621)GGG>GAG	p.G207E	RBM24_uc003nby.3_3'UTR|RBM24_uc011dix.1_Missense_Mutation_p.G149E|RBM24_uc003nca.2_Missense_Mutation_p.G162E|RBM24_uc011diy.1_Missense_Mutation_p.G121R|RBM24_uc011diz.1_Missense_Mutation_p.G106R	NM_001143942	NP_001137414	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24 isoform 1	207	Ala-rich.				cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			ovary(1)|skin(1)	2	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)			GCGGCACCTGGGACAgctgcc	0.473													6	24					0	0	0.001168	0	0
KIF13A	63971	broad.mit.edu	37	6	17837260	17837260	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:17837260T>C	uc003ncg.3	-	11	1109	c.1004A>G	c.(1003-1005)AAC>AGC	p.N335S	KIF13A_uc003ncf.2_Missense_Mutation_p.N335S|KIF13A_uc003nch.3_Missense_Mutation_p.N335S|KIF13A_uc003nci.3_Missense_Mutation_p.N335S|KIF13A_uc003ncj.2_Missense_Mutation_p.N11S	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	335					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CTCTTCATAGTTGTCTGCGGC	0.488													72	260					0	0	0.003610	0	0
KAAG1	353219	broad.mit.edu	37	6	24358102	24358102	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:24358102C>T	uc003ndz.1	+	1	972	c.235C>T	c.(235-237)CCA>TCA	p.P79S	DCDC2_uc003ndx.2_5'UTR|DCDC2_uc003ndy.2_Intron	NM_181337	NP_851854	Q9UBP8	KAAG1_HUMAN	kidney associated antigen 1	79					immune response						0						ACTGACGAATCCACAGGTGAA	0.622													12	48					0	0	0.002450	0	0
KIAA0319	9856	broad.mit.edu	37	6	24547559	24547559	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:24547559C>T	uc011djo.1	-	21	3290	c.3053G>A	c.(3052-3054)CGA>CAA	p.R1018Q	KIAA0319_uc011djp.1_Missense_Mutation_p.R973Q|KIAA0319_uc003neh.1_Missense_Mutation_p.R1018Q|KIAA0319_uc011djq.1_Missense_Mutation_p.R1009Q|KIAA0319_uc011djr.1_Missense_Mutation_p.R957Q|KIAA0319_uc010jpt.1_Missense_Mutation_p.R429Q	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	1018	Cytoplasmic (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CTCTGTGCTTCGGTGCTTGAT	0.522													13	24					0	0	0.001855	0	0
HIST1H2AA	221613	broad.mit.edu	37	6	25726745	25726745	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:25726745C>T	uc003nfc.2	-	1	46	c.11G>A	c.(10-12)CGA>CAA	p.R4Q	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	4					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CTGCTTCCCTCGTCCAGACAT	0.522													16	115					0	0	0.008871	0	0
HIST1H4A	8359	broad.mit.edu	37	6	26021936	26021936	+	Silent	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26021936T>C	uc003nfq.2	+	1	30	c.30T>C	c.(28-30)GGT>GGC	p.G10G		NM_003538	NP_003529	P62805	H4_HUMAN	histone cluster 1, H4a	10					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						GCGGGAAGGGTTTGGGTAAGG	0.577													11	55					0	0	0.000978	0	0
HIST1H1T	3010	broad.mit.edu	37	6	26108188	26108188	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26108188G>A	uc003ngj.2	-	1	177	c.134C>T	c.(133-135)TCC>TTC	p.S45F		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	45	H15.				cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						GATCAACTTGGACACAGAGAG	0.547													15	114					0	0	0.004007	0	0
HIST1H1D	3007	broad.mit.edu	37	6	26234973	26234973	+	Silent	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26234973A>T	uc003nhd.2	-	1	244	c.189T>A	c.(187-189)CTT>CTA	p.L63L		NM_005320	NP_005311	P16402	H13_HUMAN	histone cluster 1, H1d	63	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				GCGCTTTCTTAAGCGCGGCCA	0.547													50	245					0	0	0.003610	0	0
BTN3A2	11118	broad.mit.edu	37	6	26373641	26373641	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26373641C>T	uc010jqh.1	+	8	1223	c.964C>T	c.(964-966)CGT>TGT	p.R322C	BTN3A2_uc003nho.1_Missense_Mutation_p.R320C|BTN3A2_uc003nhp.2_Missense_Mutation_p.R322C|BTN3A2_uc011dkd.1_Missense_Mutation_p.R280C|BTN3A2_uc011dke.1_Missense_Mutation_p.R299C|BTN3A2_uc010jqi.1_Missense_Mutation_p.R320C	NM_007047	NP_008978	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2 precursor	322	Cytoplasmic (Potential).					integral to membrane					0						GTACTTGACTCGTGAGTGGCT	0.433													18	136					0	0	0.004990	0	0
BTN2A3	54718	broad.mit.edu	37	6	26423481	26423481	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26423481G>A	uc011dkl.1	+	2	430	c.400G>A	c.(400-402)GCC>ACC	p.A134T	BTN2A3_uc011dkm.1_RNA					RecName: Full=Butyrophilin subfamily 2 member A3; Flags: Precursor;												0						CTGCAATGAGGCCATCCTGCA	0.512													10	85					0	0	0.000978	0	0
ABT1	29777	broad.mit.edu	37	6	26598510	26598510	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26598510C>T	uc003nii.2	+	3	487	c.456C>T	c.(454-456)ACC>ACT	p.T152T		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	152					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1						ACCGTTTCACCTGGTCCCACC	0.557													30	177					0	0	0.005524	0	0
HIST1H4I	8294	broad.mit.edu	37	6	27107257	27107257	+	Missense_Mutation	SNP	G	A	A	rs140361782		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:27107257G>A	uc003niy.1	+	1	170	c.170G>A	c.(169-171)GGA>GAA	p.G57E	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	57					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						GAGACCCGCGGAGTGTTGAAG	0.632			T	BCL6	NHL								15	64					0	0	0.003163	0	0
OR2B2	81697	broad.mit.edu	37	6	27879100	27879100	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:27879100T>A	uc011dkw.1	-	1	998	c.998A>T	c.(997-999)AAC>ATC	p.N333I		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	333	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCGGAGAAGTTAGTAAGGTA	0.318													17	99					0	0	0.007413	0	0
GPX6	257202	broad.mit.edu	37	6	28472169	28472169	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28472169C>T	uc011dlj.1	-	6	616	c.566G>A	c.(565-567)GGG>GAG	p.G189E	GPX6_uc010jrg.1_RNA	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	189					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	TCCATCGGGCCCCACCAGAAA	0.522													21	85					0	0	0.001523	0	0
GPX5	2880	broad.mit.edu	37	6	28501753	28501753	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28501753C>T	uc003nll.2	+	5	477	c.475C>T	c.(475-477)CCC>TCC	p.P159S	GPX5_uc003nlm.2_3'UTR|GPX5_uc003nln.2_RNA	NM_001509	NP_001500	O75715	GPX5_HUMAN	glutathione peroxidase 5 isoform 1 precursor	159					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			skin(1)	1					Glutathione(DB00143)	CTGTCCTCATCCCTCTGAGAT	0.463													54	280					0	0	0.003610	0	0
SCAND3	114821	broad.mit.edu	37	6	28540061	28540061	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28540061C>T	uc003nlo.2	-	4	4223	c.3605G>A	c.(3604-3606)GGA>GAA	p.G1202E		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1202					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ccacaaatttcctatgcgtgg	0													6	40					0	0	0.001168	0	0
SCAND3	114821	broad.mit.edu	37	6	28541011	28541011	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28541011C>T	uc003nlo.2	-	4	3273	c.2655G>A	c.(2653-2655)ATG>ATA	p.M885I		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	885					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						gttgatcttccatatcattag	0													38	175					0	0	0.008740	0	0
SCAND3	114821	broad.mit.edu	37	6	28543816	28543816	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28543816C>T	uc003nlo.2	-	3	1284	c.666G>A	c.(664-666)ATG>ATA	p.M222I		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	222					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACTTTTCTCTCATGTTTTCTG	0.348													21	108					0	0	0.001882	0	0
TRIM27	5987	broad.mit.edu	37	6	28872399	28872399	+	Silent	SNP	G	A	A	rs141777208		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28872399G>A	uc003nlr.2	-	8	1349	c.990C>T	c.(988-990)ATC>ATT	p.I330I	TRIM27_uc003nls.2_Silent_p.I330I|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	330	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						TATCAGAGAGGATCAGGCTGG	0.552			T	RET	papillary thyroid								8	64					0	0	0.004482	0	0
OR2J2	26707	broad.mit.edu	37	6	29141649	29141649	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29141649C>T	uc011dlm.1	+	1	339	c.237C>T	c.(235-237)ATC>ATT	p.I79I		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	79	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCAGCTCTATCCCTCAGTTGC	0.483													43	251					0	0	0.007835	0	0
OR2J2	26707	broad.mit.edu	37	6	29141898	29141898	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29141898C>T	uc011dlm.1	+	1	588	c.486C>T	c.(484-486)TCC>TCT	p.S162S		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCATTCCTCCTTTACTTTCT	0.468													61	430					0	0	0.003610	0	0
OR2J2	26707	broad.mit.edu	37	6	29142344	29142344	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29142344G>A	uc011dlm.1	+	1	1034	c.932G>A	c.(931-933)GGG>GAG	p.G311E		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGGGAGTGGGGGAAGTGACAG	0.423													22	115					0	0	0.002299	0	0
OR11A1	26531	broad.mit.edu	37	6	29395052	29395053	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29395052_29395053GG>AA	uc003nmg.2	-	1	457_458	c.366_367CC>TT	c.(364-369)GACCGC>GATTGC	p.R123C		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GCCAGGTAGCGGTCATATGCCA	0.535													17	145					0	0	0.004672	0	0
MAS1L	116511	broad.mit.edu	37	6	29455262	29455262	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29455262C>T	uc011dlq.1	-	1	418	c.418G>A	c.(418-420)GGA>AGA	p.G140R		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	140	Extracellular (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						AACACGACTCCATGATAAGTT	0.507													21	59					0	0	0.001882	0	0
UBD	10537	broad.mit.edu	37	6	29523759	29523759	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29523759C>T	uc003nmo.2	-	2	620	c.396G>A	c.(394-396)GTG>GTA	p.V132V	GABBR1_uc003nmp.3_3'UTR	NM_006398	NP_006389	O15205	UBD_HUMAN	ubiquitin D	132	Ubiquitin 2.				aggresome assembly|myeloid dendritic cell differentiation|negative regulation of mitotic prometaphase|positive regulation of apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	aggresome|cytoplasm|nucleus	proteasome binding				0						CATTGCAAGTCACAATCTGGG	0.488													30	114					0	0	0.008361	0	0
GABBR1	2550	broad.mit.edu	37	6	29572283	29572283	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29572283C>T	uc003nmt.3	-	22	3036	c.2700G>A	c.(2698-2700)AAG>AAA	p.K900K	GABBR1_uc003nmp.3_Silent_p.K783K|GABBR1_uc003nms.3_Silent_p.K783K|GABBR1_uc003nmu.3_Silent_p.K838K|GABBR1_uc011dlr.1_Silent_p.K723K	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	900	Cytoplasmic (Potential).|Potential.|Interaction with ATF4 (By similarity).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	CAGCAATGATCTTTTCCAGTT	0.473													52	196					0	0	0.003610	0	0
TRIM31	11074	broad.mit.edu	37	6	30080314	30080314	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:30080314C>T	uc003npg.1	-	2	379	c.269G>A	c.(268-270)AGG>AAG	p.R90K	TRIM31_uc003npi.3_RNA	NM_007028	NP_008959	Q9BZY9	TRI31_HUMAN	tripartite motif protein 31	90	B box-type.					mitochondrion	ligase activity|zinc ion binding			lung(1)	1						AGCCTCTTTCCTTTTGGACTG	0.493													28	136					0	0	0.007291	0	0
C6orf134	79969	broad.mit.edu	37	6	30614376	30614376	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:30614376T>C	uc003nqu.2	+	13	1272	c.1222T>C	c.(1222-1224)TTC>CTC	p.F408L	C6orf134_uc003nqt.2_RNA|C6orf134_uc003nqv.2_Missense_Mutation_p.F396L|C6orf136_uc003nqx.3_5'Flank|C6orf136_uc003nqw.3_5'Flank|C6orf136_uc011dmn.1_5'Flank	NM_024909	NP_079185	Q5SQI0	ATAT_HUMAN	hypothetical protein LOC79969 isoform 2	408							tubulin N-acetyltransferase activity				0						CAACGCCAGGTTCATTCGAAA	0.592													3	22					0	0	0.000248	0	0
DHX16	8449	broad.mit.edu	37	6	30633412	30633412	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:30633412G>A	uc003nqz.2	-	5	977	c.765C>T	c.(763-765)TTC>TTT	p.F255F	DHX16_uc011dmo.1_Silent_p.F195F	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	255					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						CCCCAAAAAGGAACTCCTCAT	0.632													13	117					0	0	0.001855	0	0
NRM	11270	broad.mit.edu	37	6	30658016	30658016	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:30658016G>A	uc003nrc.2	-	2	156	c.138C>T	c.(136-138)GCC>GCT	p.A46A	KIAA1949_uc003nra.2_5'Flank|KIAA1949_uc003nrb.3_5'Flank|NRM_uc003nrd.2_RNA|NRM_uc003nre.2_Intron	NM_007243	NP_009174	Q8IXM6	NRM_HUMAN	nurim	46	Perinuclear space (Potential).					integral to membrane|nuclear inner membrane					0						ATCCCTGGCGGGCATCTACAG	0.582													5	43					0	0	0.000602	0	0
DDR1	780	broad.mit.edu	37	6	30865183	30865183	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:30865183C>T	uc003nrr.2	+	16	2284	c.2025C>T	c.(2023-2025)ATC>ATT	p.I675I	DDR1_uc010jse.2_Silent_p.I638I|DDR1_uc003nrq.2_Silent_p.I638I|DDR1_uc003nrs.2_Silent_p.I675I|DDR1_uc003nrt.2_Silent_p.I638I|DDR1_uc011dms.1_Silent_p.I656I|DDR1_uc003nru.2_Silent_p.I638I|DDR1_uc003nrv.2_Silent_p.I681I|DDR1_uc003nrw.1_Silent_p.I410I|DDR1_uc003nrz.1_5'UTR	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	675	Cytoplasmic (Potential).|Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	AGGTGAAGATCATGTCGAGGC	0.587													10	95					0	0	0.006214	0	0
C6orf15	29113	broad.mit.edu	37	6	31079437	31079437	+	Silent	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31079437T>G	uc003nsk.1	-	2	699	c.699A>C	c.(697-699)CCA>CCC	p.P233P		NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	233	Gly-rich.										0						CCTCAGGGTGTGGCATGGGCC	0.567													25	87					0	0	0.003954	0	0
C6orf15	29113	broad.mit.edu	37	6	31079678	31079679	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31079678_31079679CC>TT	uc003nsk.1	-	2	457_458	c.457_458GG>AA	c.(457-459)GGG>AAG	p.G153K	PSORS1C1_uc003nsl.1_5'Flank|PSORS1C1_uc010jsj.1_5'Flank	NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	153											0						AGAAGACTCCCCAGGCAAAGGG	0.649													17	135					0	0	0.004672	0	0
POU5F1	5460	broad.mit.edu	37	6	31133377	31133377	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31133377C>T	uc003nsv.2	-	3	682	c.628G>A	c.(628-630)GAA>AAA	p.E210K	POU5F1_uc003nsu.2_Missense_Mutation_p.E115K|uc011dnf.1_5'Flank	NM_002701	NP_002692	Q01860	PO5F1_HUMAN	POU domain, class 5, transcription factor 1	210	POU-specific.				anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	skin(7)|salivary_gland(2)|bone(2)|lung(1)|ovary(1)	13						TTGTCAGCTTCCTCCACCCAC	0.527			T	EWSR1	sarcoma								10	99					0	0	0.006214	0	0
HCG27	253018	broad.mit.edu	37	6	31170622	31170622	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31170622C>T	uc011dni.1	+	2		c.597C>T				NR_026791				Homo sapiens cDNA FLJ40123 fis, clone TESTI2010280.												0						CCTTCTGCCCCATCCCCAGGC	0.532													64	196					0	0	0.003610	0	0
TNF	7124	broad.mit.edu	37	6	31543539	31543539	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31543539C>T	uc003nui.2	+	1	190	c.21C>T	c.(19-21)ATC>ATT	p.I7I	TNF_uc003nuj.2_5'Flank	NM_000594	NP_000585	P01375	TNFA_HUMAN	tumor necrosis factor alpha	7	Cytoplasmic (Potential).				activation of caspase activity|activation of MAPK activity|activation of MAPKKK activity|anti-apoptosis|cellular response to nicotine|chronic inflammatory response to antigenic stimulus|embryonic digestive tract development|induction of apoptosis via death domain receptors|induction of necroptosis by extracellular signals|leukocyte tethering or rolling|necrotic cell death|negative regulation of branching involved in lung morphogenesis|negative regulation of cytokine secretion involved in immune response|negative regulation of fat cell differentiation|negative regulation of interleukin-6 production|negative regulation of lipid catabolic process|negative regulation of lipid storage|negative regulation of viral genome replication|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of chemokine biosynthetic process|positive regulation of chemokine production|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of fever generation|positive regulation of heterotypic cell-cell adhesion|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of NFAT protein import into nucleus|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of podosome assembly|positive regulation of protein complex disassembly|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|receptor biosynthetic process|regulation of insulin secretion|response to glucocorticoid stimulus|response to salt stress|response to virus|sequestering of triglyceride|transformed cell apoptosis|tumor necrosis factor-mediated signaling pathway	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane raft|phagocytic cup|recycling endosome	cytokine activity|identical protein binding|protease binding|transcription regulatory region DNA binding|tumor necrosis factor receptor binding			ovary(1)|pancreas(1)|skin(1)	3		Ovarian(999;0.00556)			Adalimumab(DB00051)|Adenosine(DB00640)|Amrinone(DB01427)|Atorvastatin(DB01076)|Chloroquine(DB00608)|Clenbuterol(DB01407)|Etanercept(DB00005)|Glucosamine(DB01296)|Infliximab(DB00065)|Naltrexone(DB00704)|Pranlukast(DB01411)|Procaterol(DB01366)|Saquinavir(DB01232)|Simvastatin(DB00641)|Thalidomide(DB01041)	AAAGCATGATCCGGGACGTGG	0.622									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				24	324					0	0	0.004656	0	0
TNF	7124	broad.mit.edu	37	6	31545302	31545302	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31545302C>T	uc003nui.2	+	4	859	c.690C>T	c.(688-690)ATC>ATT	p.I230I	TNF_uc003nuj.2_Missense_Mutation_p.S82L	NM_000594	NP_000585	P01375	TNFA_HUMAN	tumor necrosis factor alpha	230	Extracellular (Potential).				activation of caspase activity|activation of MAPK activity|activation of MAPKKK activity|anti-apoptosis|cellular response to nicotine|chronic inflammatory response to antigenic stimulus|embryonic digestive tract development|induction of apoptosis via death domain receptors|induction of necroptosis by extracellular signals|leukocyte tethering or rolling|necrotic cell death|negative regulation of branching involved in lung morphogenesis|negative regulation of cytokine secretion involved in immune response|negative regulation of fat cell differentiation|negative regulation of interleukin-6 production|negative regulation of lipid catabolic process|negative regulation of lipid storage|negative regulation of viral genome replication|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of chemokine biosynthetic process|positive regulation of chemokine production|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of fever generation|positive regulation of heterotypic cell-cell adhesion|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of NFAT protein import into nucleus|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of podosome assembly|positive regulation of protein complex disassembly|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|receptor biosynthetic process|regulation of insulin secretion|response to glucocorticoid stimulus|response to salt stress|response to virus|sequestering of triglyceride|transformed cell apoptosis|tumor necrosis factor-mediated signaling pathway	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane raft|phagocytic cup|recycling endosome	cytokine activity|identical protein binding|protease binding|transcription regulatory region DNA binding|tumor necrosis factor receptor binding			ovary(1)|pancreas(1)|skin(1)	3		Ovarian(999;0.00556)			Adalimumab(DB00051)|Adenosine(DB00640)|Amrinone(DB01427)|Atorvastatin(DB01076)|Chloroquine(DB00608)|Clenbuterol(DB01407)|Etanercept(DB00005)|Glucosamine(DB01296)|Infliximab(DB00065)|Naltrexone(DB00704)|Pranlukast(DB01411)|Procaterol(DB01366)|Saquinavir(DB01232)|Simvastatin(DB00641)|Thalidomide(DB01041)	ACTTTGGGATCATTGCCCTGT	0.572									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				15	135					0	0	0.004990	0	0
BAT2	7916	broad.mit.edu	37	6	31594583	31594583	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31594583C>T	uc003nvb.3	+	10	1266	c.1017C>T	c.(1015-1017)CTC>CTT	p.L339L	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Silent_p.L339L	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	339	4 X 57 AA type A repeats.|2 X type B repeats.|2-1.					cytoplasm|nucleus	protein binding				0						CTGAAAAGCTCAAGTTCAGCG	0.527													5	43					0	0	0.001984	0	0
BAT3	7917	broad.mit.edu	37	6	31617103	31617103	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31617103G>T	uc003nvg.3	-	4	610	c.296C>A	c.(295-297)TCT>TAT	p.S99Y	BAT3_uc003nvf.3_Missense_Mutation_p.S99Y|BAT3_uc003nvh.3_Missense_Mutation_p.S99Y|BAT3_uc003nvi.3_Missense_Mutation_p.S99Y|BAT3_uc011dnw.1_Missense_Mutation_p.S99Y|BAT3_uc011dnx.1_Missense_Mutation_p.S99Y|BAT3_uc003nvj.1_Missense_Mutation_p.S99Y	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	99					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						CGTCCCAGAAGATGCCCCAGA	0.577													49	808					2.17126e-26	3.32576e-26	0.003610	1	0
C6orf25	80739	broad.mit.edu	37	6	31692559	31692559	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31692559G>A	uc011doc.1	+	5	559	c.559G>A	c.(559-561)GAG>AAG	p.E187K	C6orf25_uc003nwk.2_Missense_Mutation_p.R193Q|C6orf25_uc011dod.1_Missense_Mutation_p.E143K|C6orf25_uc011doe.1_Missense_Mutation_p.E163K|C6orf25_uc003nwo.2_Missense_Mutation_p.R149Q|C6orf25_uc003nwn.2_Missense_Mutation_p.R193Q	NM_138272	NP_612116	O95866	G6B_HUMAN	G6B protein isoform G6b-B precursor	187	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity				0						TGTGAAAACCGAGCCCCAGAG	0.572													75	480					0	0	0.003610	0	0
CLIC1	1192	broad.mit.edu	37	6	31700063	31700063	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31700063C>T	uc003nwr.2	-	5	759	c.495G>A	c.(493-495)AGG>AGA	p.R165R	DDAH2_uc003nwp.2_5'Flank|DDAH2_uc003nwq.2_5'Flank|CLIC1_uc003rje.2_Silent_p.R165R	NM_001288	NP_001279	O00299	CLIC1_HUMAN	chloride intracellular channel 1	165	GST C-terminal.				signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						CCAAAAACTTCCTCTGAGAGA	0.488													168	745					0	0	0.003610	0	0
VARS	7407	broad.mit.edu	37	6	31746792	31746792	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31746792G>A	uc003nxe.2	-	29	4101	c.3678C>T	c.(3676-3678)GGC>GGT	p.G1226G	C6orf27_uc011dog.1_5'Flank|C6orf27_uc003nxd.2_5'Flank|C6orf27_uc011doh.1_5'Flank|VARS_uc003nxf.1_Silent_p.G163G	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	1226					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	TGACAGGATAGCCCGAGGCAG	0.647													55	533					0	0	0.003610	0	0
VARS	7407	broad.mit.edu	37	6	31762881	31762881	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31762881G>A	uc003nxe.2	-	2	537	c.114C>T	c.(112-114)CCC>CCT	p.P38P	VARS_uc011doi.1_Intron	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	38					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GACAGATGCGGGGGTGGGCTC	0.721													64	292					0	0	0.003610	0	0
EHMT2	10919	broad.mit.edu	37	6	31860664	31860665	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31860664_31860665GG>AA	uc003nxz.1	-	5	615_616	c.605_606CC>TT	c.(604-606)CCC>CTT	p.P202L	EHMT2_uc003nxy.1_5'UTR|EHMT2_uc011don.1_Missense_Mutation_p.P259L|EHMT2_uc003nya.1_Missense_Mutation_p.P202L	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	202					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GTATTTCAGGGGGCCGCTTCTC	0.619													84	732					0	0	0.004672	0	0
ZBTB12	221527	broad.mit.edu	37	6	31868259	31868259	+	Missense_Mutation	SNP	C	T	T	rs143624178		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31868259C>T	uc003nyd.1	-	2	1000	c.824G>A	c.(823-825)GGG>GAG	p.G275E	EHMT2_uc003nxz.1_5'Flank|EHMT2_uc003nya.1_5'Flank|EHMT2_uc003nyb.1_5'Flank|C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_5'Flank	NM_181842	NP_862825	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	275	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGGCCCTCCCCTTCTGCATC	0.632													39	211					0	0	0.008740	0	0
CFB	629	broad.mit.edu	37	6	31915562	31915562	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31915562C>T	uc003nyj.3	+	5	980	c.702C>T	c.(700-702)TTC>TTT	p.F234F	CFB_uc011dor.1_Silent_p.F736F|CFB_uc003nyi.2_Silent_p.F234F	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	234					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						CCGAAGCTTTCCTGTCTTCCC	0.552													322	537					0	0	0.003610	0	0
CFB	629	broad.mit.edu	37	6	31918170	31918170	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31918170G>A	uc003nyj.3	+	12	1892	c.1614G>A	c.(1612-1614)AAG>AAA	p.K538K	CFB_uc011dor.1_Silent_p.K1040K|CFB_uc003nyi.2_Silent_p.K538K	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	538	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						ACTCAATCAAGGTCAGCGTAG	0.522													108	732					0	0	0.003610	0	0
RDBP	7936	broad.mit.edu	37	6	31922080	31922080	+	Silent	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31922080G>T	uc003nyk.2	-	8	1086	c.882C>A	c.(880-882)CCC>CCA	p.P294P	RDBP_uc011dot.1_Silent_p.P264P|RDBP_uc003nyl.1_Silent_p.P234P	NM_002904	NP_002895	P18615	NELFE_HUMAN	RD RNA-binding protein	294	RRM.				positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	mitochondrion|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						CTTACTTTCTGGGTGGGTCCA	0.522													18	894					7.07596e-05	0.000107065	0.006122	1	0
SKIV2L	6499	broad.mit.edu	37	6	31928457	31928457	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31928457C>T	uc003nyn.1	+	6	873	c.484C>T	c.(484-486)CCC>TCC	p.P162S	RDBP_uc003nyk.2_5'Flank|RDBP_uc011dot.1_5'Flank|RDBP_uc003nyl.1_5'Flank|RDBP_uc003nym.1_5'Flank|SKIV2L_uc011dou.1_Missense_Mutation_p.P4S|SKIV2L_uc011dov.1_Intron	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	162						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						GATGGATGAACCCACCATAAC	0.527													73	777					0	0	0.003610	0	0
C4A	720	broad.mit.edu	37	6	31964370	31964370	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31964370G>A	uc011doy.1	+	28	3720	c.3669G>A	c.(3667-3669)GAG>GAA	p.E1223E	C4A_uc011doz.1_Silent_p.E1223E	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	1223					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						TGGCCCAGGAGACTGGAGGTG	0.637													11	154					0	0	0.001855	0	0
TNXB	7148	broad.mit.edu	37	6	31978814	31978814	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31978814C>T	uc011dpc.1	-	4	1584	c.675G>A	c.(673-675)GGG>GGA	p.G225G	STK19_uc003nza.2_5'Flank|STK19_uc003nzb.2_5'Flank	NM_032470	NP_115859	P22105	TENX_HUMAN	tenascin XB isoform 2	3841	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTGAGGCTCCCCTGAAAACG	0.632													46	214					0	0	0.003610	0	0
C4A	720	broad.mit.edu	37	6	31997536	31997536	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31997536C>T	uc011dpd.1	+	29	3921	c.3870C>T	c.(3868-3870)ACC>ACT	p.T1290T	C4A_uc011dpe.1_Silent_p.T1290T	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	1290					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						CCTGGCTCACCCGTCAGGGCA	0.652													13	194					0	0	0.002450	0	0
TNXB	7148	broad.mit.edu	37	6	32023726	32023726	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32023726G>A	uc003nzl.2	-	24	8571	c.8369C>T	c.(8368-8370)ACC>ATC	p.T2790I		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2848	Fibronectin type-III 20.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GCCCCCCACGGTGACCTCGCT	0.682													157	717					0	0	0.003610	0	0
TNXB	7148	broad.mit.edu	37	6	32026088	32026088	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32026088G>A	uc003nzl.2	-	22	7774	c.7572C>T	c.(7570-7572)CTC>CTT	p.L2524L		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2584	Fibronectin type-III 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GCTCCCCCAGGAGAGGCTCCT	0.632													72	794					0	0	0.003610	0	0
TNXB	7148	broad.mit.edu	37	6	32047071	32047071	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32047071C>T	uc003nzl.2	-	11	4316	c.4114G>A	c.(4114-4116)GAG>AAG	p.E1372K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1459	Fibronectin type-III 7.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AGGAGCGGCTCCTCGGGGGAC	0.637													51	545					0	0	0.003610	0	0
TNXB	7148	broad.mit.edu	37	6	32053871	32053871	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32053871C>T	uc003nzl.2	-	7	3006	c.2804G>A	c.(2803-2805)GGG>GAG	p.G935E		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ATCGGTAGTCCCCAAGAGGCC	0.627													34	393					0	0	0.006230	0	0
TNXB	7148	broad.mit.edu	37	6	32065661	32065661	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32065661G>A	uc003nzl.2	-	2	517	c.315C>T	c.(313-315)GTC>GTT	p.V105V	TNXB_uc010jts.1_Silent_p.V104V|ATF6B_uc003nzm.1_3'UTR	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	105					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTCTAGACGGACCCTCAGGG	0.612													79	721					0	0	0.003610	0	0
ATF6B	1388	broad.mit.edu	37	6	32087714	32087715	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32087714_32087715GG>AA	uc003nzn.2	-	9	885_886	c.852_853CC>TT	c.(850-855)ATCCAG>ATTTAG	p.Q285*	TNXB_uc010jts.1_5'Flank|ATF6B_uc003nzm.1_5'Flank|ATF6B_uc003nzo.2_Nonsense_Mutation_p.Q282*|ATF6B_uc003nzp.1_5'UTR	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	285	Cytoplasmic (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ATAGCACCCTGGATGAGGACAA	0.619													187	525					0	0	0.004672	0	0
ATF6B	1388	broad.mit.edu	37	6	32093947	32093947	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32093947G>A	uc003nzn.2	-	5	458	c.425C>T	c.(424-426)TCC>TTC	p.S142F	ATF6B_uc003nzo.2_Missense_Mutation_p.S139F|ATF6B_uc011dpg.1_Missense_Mutation_p.S76F|ATF6B_uc011dph.1_Missense_Mutation_p.S142F	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	142	Cytoplasmic (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTCAAATGAGGATGTTGGGTC	0.532													148	748					0	0	0.003610	0	0
PRRT1	80863	broad.mit.edu	37	6	32118479	32118480	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32118479_32118480GG>AA	uc003nzt.2	-	2	339_340	c.223_224CC>TT	c.(223-225)CCC>TTC	p.P75F	PRRT1_uc003nzs.2_Missense_Mutation_p.P116F|PRRT1_uc003nzu.2_Intron|PPT2_uc003nzw.2_5'Flank	NM_030651	NP_085154	Q99946	PRRT1_HUMAN	NG5 protein	75					response to biotic stimulus	integral to membrane				breast(1)	1						AGAGGAGGAGGGACCGCGCTGA	0.673													14	143					0	0	0.004672	0	0
AGPAT1	10554	broad.mit.edu	37	6	32138758	32138758	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32138758G>A	uc003oae.2	-	3	608	c.290C>T	c.(289-291)CCC>CTC	p.P97L	PPT2_uc003nzy.1_RNA|AGPAT1_uc011dpj.1_RNA|AGPAT1_uc011dpk.1_Missense_Mutation_p.P61L|AGPAT1_uc003oaf.2_Missense_Mutation_p.P97L|AGPAT1_uc003oag.2_Intron|AGPAT1_uc003oah.2_Missense_Mutation_p.P97L|AGPAT1_uc003oai.1_Missense_Mutation_p.P97L|AGPAT1_uc011dpl.1_Intron	NM_006411	NP_006402	Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	97					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)	1						AACAACATAGGGCTGCGAGGG	0.592													95	810					0	0	0.003610	0	0
NOTCH4	4855	broad.mit.edu	37	6	32185012	32185012	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32185012G>A	uc003obb.2	-	10	1795	c.1656C>T	c.(1654-1656)ATC>ATT	p.I552I	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Silent_p.I552I	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	552	Extracellular (Potential).|EGF-like 14; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						TGCACTCATCGATATCCTCCT	0.622													80	416					0	0	0.003610	0	0
NOTCH4	4855	broad.mit.edu	37	6	32187406	32187406	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32187406C>T	uc003obb.2	-	8	1612	c.1473G>A	c.(1471-1473)CTG>CTA	p.L491L	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Silent_p.L491L	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	491	EGF-like 12; calcium-binding (Potential).|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CAAGTAGGTCCAGACAGGTGC	0.592													64	504					0	0	0.003610	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188373	32188373	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32188373G>A	uc003obb.2	-	6	1107	c.968C>T	c.(967-969)CCC>CTC	p.P323L	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.P323L	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	323	EGF-like 8; calcium-binding (Potential).|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GCAGTGAGGGGGACCCTGGGT	0.627													57	268					0	0	0.003610	0	0
PSMB8	5696	broad.mit.edu	37	6	32811717	32811717	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32811717G>A	uc003oce.2	-	1	100	c.57C>T	c.(55-57)CTC>CTT	p.L19L	PSMB8_uc003ocf.2_Intron|PSMB8_uc011dqh.1_Silent_p.L19L	NM_148919	NP_683720	P28062	PSB8_HUMAN	proteasome beta 8 subunit isoform E2 proprotein	19					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			skin(1)	1						CCGCAACCGGGAGAGCCGATT	0.652													24	170					0	0	0.004656	0	0
PPP1R2P1	5505	broad.mit.edu	37	6	32847367	32847367	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32847367C>T	uc011dqk.1	+	1		c.3113C>T				NR_027771				Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 1 (PPP1R2P1), non-coding RNA.												0						GCATCTTCATCATCACCCATC	0.428													8	40					0	0	0.003080	0	0
COL11A2	1302	broad.mit.edu	37	6	33154559	33154559	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:33154559G>A	uc003ocx.1	-	5	871	c.643C>T	c.(643-645)CAG>TAG	p.Q215*	COL11A2_uc003ocy.1_Nonsense_Mutation_p.Q215*|COL11A2_uc003ocz.1_Nonsense_Mutation_p.Q215*|COL11A2_uc003oda.2_Nonsense_Mutation_p.Q215*	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	215	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TAGGCTGCCTGGACCCCTGGG	0.567													23	288					0	0	0.004656	0	0
ZBTB9	221504	broad.mit.edu	37	6	33423517	33423517	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:33423517G>A	uc003oeq.2	+	2	908	c.640G>A	c.(640-642)GAA>AAA	p.E214K		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ggtggaagaagaagaggagga	0.443													21	123					0	0	0.001523	0	0
SPDEF	25803	broad.mit.edu	37	6	34508834	34508834	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:34508834C>T	uc003ojq.1	-	3	976	c.561G>A	c.(559-561)TCG>TCA	p.S187S	SPDEF_uc011dsq.1_Silent_p.S187S	NM_012391	NP_036523	O95238	SPDEF_HUMAN	SAM pointed domain containing ets transcription	187	PNT.				negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(3)|ovary(1)|central_nervous_system(1)	5						ACTGCTCCTCCGACATGGCGC	0.652													8	38					0	0	0.003080	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34823398	34823398	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:34823398C>T	uc003oju.3	+	9	1272	c.1038C>T	c.(1036-1038)GTC>GTT	p.V346V	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_Intron|UHRF1BP1_uc010jvo.2_5'Flank	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	346										ovary(3)	3						TTATAGGTGTCTCTGCCAACA	0.458													32	143					0	0	0.003755	0	0
TULP1	7287	broad.mit.edu	37	6	35480454	35480454	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:35480454C>T	uc003okv.3	-	2	73	c.61G>A	c.(61-63)GAA>AAA	p.E21K	TULP1_uc003okw.3_Missense_Mutation_p.E21K	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	21					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						CTCAGGCTTTCTTCTTCATGC	0.473													18	110					0	0	0.008871	0	0
CLPS	1208	broad.mit.edu	37	6	35763630	35763630	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:35763630C>T	uc003ole.1	-	2	122	c.85G>A	c.(85-87)GAG>AAG	p.E29K	CLPS_uc003olf.1_Intron	NM_001832	NP_001823	P04118	COL_HUMAN	colipase preproprotein	29					lipid catabolic process|lipid digestion|retinoid metabolic process|steroid metabolic process	extracellular region					0						TCACCGTTCTCCTGCCAGGAG	0.597													28	150					0	0	0.002096	0	0
LHFPL5	222662	broad.mit.edu	37	6	35773696	35773696	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:35773696C>T	uc003olg.1	+	1	626	c.249C>T	c.(247-249)CCC>CCT	p.P83P		NM_182548	NP_872354	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	83						integral to membrane				skin(1)	1						AGGGCGGCCCCCTAGACTTCT	0.577													46	249					0	0	0.003610	0	0
SRPK1	6732	broad.mit.edu	37	6	35825091	35825091	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:35825091G>A	uc003olj.2	-	13	1690	c.1567C>T	c.(1567-1569)CTA>TTA	p.L523L	SRPK1_uc011dtg.1_Silent_p.L507L|SRPK1_uc003olh.2_Silent_p.L416L|SRPK1_uc003oli.2_Silent_p.L416L	NM_003137	NP_003128	Q96SB4	SRPK1_HUMAN	SFRS protein kinase 1	523	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						GATCCGATTAGAACTTCCAAG	0.368													10	43					0	0	0.001368	0	0
ETV7	51513	broad.mit.edu	37	6	36334473	36334473	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:36334473C>T	uc003omb.2	-	8	1124	c.975G>A	c.(973-975)CAG>CAA	p.Q325Q	ETV7_uc003olz.1_Intron|ETV7_uc003oma.1_Intron|ETV7_uc010jwg.2_RNA|ETV7_uc003omc.2_Silent_p.Q270Q|ETV7_uc010jwj.2_Silent_p.Q266Q|ETV7_uc010jwh.2_Silent_p.Q244Q|ETV7_uc010jwi.2_Silent_p.Q248Q|ETV7_uc011dtl.1_Silent_p.Q174Q	NM_016135	NP_057219	Q9Y603	ETV7_HUMAN	ets variant 7	325					organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						TGTCCTGCTCCTGGCTCTCCA	0.572													22	129					0	0	0.002780	0	0
DNAH8	1769	broad.mit.edu	37	6	38840747	38840747	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:38840747G>A	uc003ooe.1	+	49	7252	c.6652G>A	c.(6652-6654)GTT>ATT	p.V2218I		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CTTAAATTCCGTTTTGGATGA	0.383													30	142					0	0	0.007291	0	0
KCNK17	89822	broad.mit.edu	37	6	39267263	39267263	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:39267263C>T	uc003ooo.2	-	5	1079	c.939G>A	c.(937-939)ATG>ATA	p.M313I	KCNK17_uc003oop.2_3'UTR	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	313	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						GTATGATTCCCATGGGTCCCT	0.408													8	64					0	0	0.006214	0	0
KCNK17	89822	broad.mit.edu	37	6	39271779	39271779	+	Silent	SNP	G	A	A	rs140940240	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:39271779G>A	uc003ooo.2	-	4	782	c.642C>T	c.(640-642)TTC>TTT	p.F214F	KCNK17_uc003oop.2_Silent_p.F214F	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	214						integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						TGATGAAGGCGAAGTAGAAGC	0.632													26	111					0	0	0.007291	0	0
DAAM2	23500	broad.mit.edu	37	6	39847148	39847149	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:39847148_39847149CC>TT	uc003oow.2	+	14	1896_1897	c.1740_1741CC>TT	c.(1738-1743)CCCCTC>CCTTTC	p.L581F	DAAM2_uc010jxc.2_Missense_Mutation_p.L581F|DAAM2_uc003oox.2_Missense_Mutation_p.L581F	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	581	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					TGGGCCTGCCCCTCCCTCAGGA	0.505													5	66					0	0	0.004672	0	0
LRFN2	57497	broad.mit.edu	37	6	40400350	40400350	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:40400350G>A	uc003oph.1	-	2	968	c.503C>T	c.(502-504)TCC>TTC	p.S168F		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	168	LRR 5.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCGTCGCACGGAGTCCCACGG	0.607													28	112					0	0	0.006320	0	0
LRFN2	57497	broad.mit.edu	37	6	40400382	40400382	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:40400382G>A	uc003oph.1	-	2	936	c.471C>T	c.(469-471)TCC>TCT	p.S157S		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	157	LRR 5.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGTTGTTGTAGGAGAGGTCCA	0.582													20	86					0	0	0.007413	0	0
APOBEC2	10930	broad.mit.edu	37	6	41021152	41021152	+	Silent	SNP	G	A	A	rs116667889	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41021152G>A	uc003opl.2	+	1	213	c.66G>A	c.(64-66)GAG>GAA	p.E22E	UNC5CL_uc010jxe.1_Intron|APOBEC2_uc010jxf.2_RNA	NM_006789	NP_006780	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	22					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGGATCTGGAGAACCTGGACG	0.592													21	112					0	0	0.003330	0	0
TREML1	340205	broad.mit.edu	37	6	41121741	41121742	+	Missense_Mutation	DNP	TC	GT	GT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41121741_41121742TC>GT	uc011duc.1	-	2	174_175	c.130_131GA>AC	c.(130-132)GAT>ACT	p.D44T	TREML1_uc003opx.2_Missense_Mutation_p.D44T|TREML1_uc011dud.1_Intron	NM_178174	NP_835468	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid	44	Ig-like V-type.|Extracellular (Potential).				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGCTTTGACATCCTGGAGCCTG	0.634													11	71					0	0	0.004672	0	0
NCR2	9436	broad.mit.edu	37	6	41318576	41318576	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41318576G>A	uc003oqh.2	+	5	892	c.805G>A	c.(805-807)GAT>AAT	p.D269N	NCR2_uc003oqi.2_3'UTR|NCR2_uc003oqj.2_3'UTR	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	269	Poly-Asp.|Cytoplasmic (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					taagataagcgatgatgatga	0.124													7	78					0	0	0.001984	0	0
FOXP4	116113	broad.mit.edu	37	6	41558050	41558050	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41558050C>T	uc003oql.2	+	12	1857	c.1399C>T	c.(1399-1401)CGG>TGG	p.R467W	FOXP4_uc003oqm.2_Missense_Mutation_p.R465W|FOXP4_uc003oqn.2_Missense_Mutation_p.R454W	NM_001012426	NP_001012426	Q8IVH2	FOXP4_HUMAN	forkhead box P4 isoform 1	467	Fork-head.				embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CGCCGACGTCCGGCCCCCCTT	0.632													22	158					0	0	0.002780	0	0
TFEB	7942	broad.mit.edu	37	6	41654886	41654886	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41654886T>C	uc003oqs.1	-	8	1051	c.749A>G	c.(748-750)AAC>AGC	p.N250S	TFEB_uc003oqt.1_Missense_Mutation_p.N250S|TFEB_uc003oqu.1_Missense_Mutation_p.N264S|TFEB_uc003oqv.1_Missense_Mutation_p.N250S|TFEB_uc003oqr.1_Missense_Mutation_p.N165S	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	250	Helix-loop-helix motif.				embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GTCATTGATGTTGAACCTTCG	0.557			T	ALPHA	renal (childhood epithelioid)								12	80					0	0	0.003163	0	0
PGC	5225	broad.mit.edu	37	6	41710162	41710162	+	Silent	SNP	G	A	A	rs146180846	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41710162G>A	uc003ora.1	-	5	562	c.513C>T	c.(511-513)TTC>TTT	p.F171F		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	171					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GCGCATAGACGAAGTTGGTAC	0.592													20	83					0	0	0.001523	0	0
CCND3	896	broad.mit.edu	37	6	41909260	41909260	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41909260G>A	uc003orn.2	-	1	293	c.128C>T	c.(127-129)TCC>TTC	p.S43F	CCND3_uc003orp.2_Intron|CCND3_uc011duk.1_Intron|CCND3_uc011dum.1_Intron|CCND3_uc003orm.2_5'Flank|CCND3_uc003oro.2_Missense_Mutation_p.S43F|CCND3_uc011dul.1_Missense_Mutation_p.S43F	NM_001760	NP_001751	P30281	CCND3_HUMAN	cyclin D3 isoform 2	43	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTGGAAGTAGGAGGCGCGGGG	0.582			T	IGH@	MM								6	38					0	0	0.001168	0	0
UBR2	23304	broad.mit.edu	37	6	42582840	42582840	+	Silent	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:42582840T>C	uc011dur.1	+	9	1017	c.1017T>C	c.(1015-1017)GGT>GGC	p.G339G	UBR2_uc011dus.1_5'UTR|UBR2_uc010jxv.1_5'Flank|UBR2_uc003osh.2_5'Flank|UBR2_uc003osf.2_Silent_p.G339G	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	339					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GTCAAGTTGGTTTACAAGAAG	0.353													38	140					0	0	0.002522	0	0
KIAA0240	23506	broad.mit.edu	37	6	42832752	42832752	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:42832752C>T	uc003osn.1	+	13	2959	c.2808C>T	c.(2806-2808)GGC>GGT	p.G936G	KIAA0240_uc011duw.1_Silent_p.G936G|KIAA0240_uc003osp.1_Silent_p.G936G	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	936										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			GCTCTCCCGGCCCTGAGGGGC	0.537													14	70					0	0	0.003163	0	0
PEX6	5190	broad.mit.edu	37	6	42934388	42934388	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:42934388C>T	uc003otf.2	-	10	2062	c.1969G>A	c.(1969-1971)GGT>AGT	p.G657S	PEX6_uc010jya.2_RNA	NM_000287	NP_000278	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	657					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)	1			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			GTCAAGCCACCTGCCAAACTG	0.577													31	170					0	0	0.001786	0	0
KLC4	89953	broad.mit.edu	37	6	43034148	43034148	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43034148C>T	uc003otv.1	+	5	753	c.676C>T	c.(676-678)CGC>TGC	p.R226C	KLC4_uc003otr.1_RNA|KLC4_uc011dvd.1_Missense_Mutation_p.R149C|KLC4_uc003otu.2_Missense_Mutation_p.R226C|KLC4_uc003otw.1_Missense_Mutation_p.R244C|KLC4_uc003otx.1_Missense_Mutation_p.R226C|KLC4_uc003oty.1_Missense_Mutation_p.R226C|KLC4_uc003otz.1_Missense_Mutation_p.R226C	NM_201521	NP_958929	Q9NSK0	KLC4_HUMAN	kinesin-like 8 isoform a	226	TPR 2.					cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			skin(3)|ovary(1)	4			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			AGCCCAAGGTCGCTATGAGGT	0.597													22	98					0	0	0.002780	0	0
KLC4	89953	broad.mit.edu	37	6	43041663	43041663	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43041663C>T	uc003otv.1	+	15	1846	c.1769C>T	c.(1768-1770)TCC>TTC	p.S590F	PTK7_uc003oub.1_5'Flank|PTK7_uc003ouc.1_5'Flank|PTK7_uc003oud.1_5'Flank|PTK7_uc003oue.1_5'Flank|PTK7_uc003ouf.1_5'Flank|PTK7_uc003oug.1_5'Flank|PTK7_uc011dve.1_5'Flank|KLC4_uc003otr.1_RNA|KLC4_uc011dvd.1_Missense_Mutation_p.S513F|KLC4_uc003otw.1_Missense_Mutation_p.S608F|KLC4_uc003otx.1_Missense_Mutation_p.S590F|KLC4_uc003oty.1_Missense_Mutation_p.S590F|KLC4_uc003otz.1_Missense_Mutation_p.S590F|PTK7_uc003oua.2_5'Flank	NM_201521	NP_958929	Q9NSK0	KLC4_HUMAN	kinesin-like 8 isoform a	590						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			skin(3)|ovary(1)	4			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			CGAGCAGCCTCCTTGAACTAT	0.527													22	120					0	0	0.004656	0	0
PTK7	5754	broad.mit.edu	37	6	43099757	43099757	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43099757C>T	uc003oub.1	+	6	1014	c.816C>T	c.(814-816)CCC>CCT	p.P272P	PTK7_uc003ouc.1_Silent_p.P272P|PTK7_uc003oud.1_Silent_p.P272P|PTK7_uc003oue.1_Silent_p.P272P|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Silent_p.P280P|PTK7_uc010jyj.1_5'Flank|PTK7_uc003oua.2_Silent_p.P272P	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	272	Ig-like C2-type 3.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			TCTGCAGCCCCCCACACCTCC	0.582													15	77					0	0	0.008871	0	0
SRF	6722	broad.mit.edu	37	6	43146877	43146877	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43146877C>T	uc003oui.2	+	7	1951	c.1476C>T	c.(1474-1476)ACC>ACT	p.T492T	SRF_uc011dvf.1_Silent_p.T288T	NM_003131	NP_003122	P11831	SRF_HUMAN	serum response factor (c-fos serum response	492					angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|transcription from RNA polymerase II promoter|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			ovary(1)|breast(1)|central_nervous_system(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GCAACCTCACCGAGCTACAGG	0.622													16	76					0	0	0.006122	0	0
CUL9	23113	broad.mit.edu	37	6	43154031	43154031	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43154031C>T	uc003ouk.2	+	4	1164	c.1089C>T	c.(1087-1089)TTC>TTT	p.F363F	CUL9_uc003ouj.1_Silent_p.F363F|CUL9_uc003oul.2_Silent_p.F363F|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	363					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GGTGGGTCTTCCGCCAGCGCT	0.577													17	138					0	0	0.001523	0	0
TTBK1	84630	broad.mit.edu	37	6	43225664	43225664	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43225664C>T	uc003ouq.1	+	10	1255	c.976C>T	c.(976-978)CCG>TCG	p.P326S		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	326						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CACCTCTACCCCGCCCCAGCA	0.617													9	80					0	0	0.001855	0	0
TTBK1	84630	broad.mit.edu	37	6	43226883	43226884	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43226883_43226884CC>TT	uc003ouq.1	+	11	1403_1404	c.1124_1125CC>TT	c.(1123-1125)CCC>CTT	p.P375L		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	375						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCAATTCTGCCCGGGAGGCCCT	0.644													18	103					0	0	0.004672	0	0
ZNF318	24149	broad.mit.edu	37	6	43322651	43322651	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43322651G>A	uc003oux.2	-	4	2499	c.2421C>T	c.(2419-2421)ACC>ACT	p.T807T	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	807					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			ACGGTTGAGAGGTGGGATACA	0.527													22	93					0	0	0.001882	0	0
TJAP1	93643	broad.mit.edu	37	6	43473457	43473457	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43473457C>T	uc003ovd.2	+	11	1914	c.1538C>T	c.(1537-1539)TCC>TTC	p.S513F	TJAP1_uc003ovf.2_Missense_Mutation_p.S503F|TJAP1_uc003ove.2_Missense_Mutation_p.S503F|TJAP1_uc003ovc.2_Missense_Mutation_p.S503F|TJAP1_uc010jyp.2_Missense_Mutation_p.S472F|TJAP1_uc011dvh.1_Missense_Mutation_p.S503F|TJAP1_uc003ovg.2_Missense_Mutation_p.S379F|TJAP1_uc011dvi.1_Missense_Mutation_p.S513F|TJAP1_uc011dvj.1_Missense_Mutation_p.S313F|TJAP1_uc003ovi.2_Missense_Mutation_p.S379F	NM_001146016	NP_001139488	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 isoform a	513						Golgi apparatus|tight junction	protein binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CCAGGCACTTCCCACACCGAG	0.662													5	34					0	0	0.001168	0	0
CAPN11	11131	broad.mit.edu	37	6	44149035	44149035	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:44149035G>A	uc003owt.1	+	19	1954	c.1916G>A	c.(1915-1917)TGG>TAG	p.W639*	CAPN11_uc011dvn.1_Nonsense_Mutation_p.W293*	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	639	EF-hand 1.|Domain IV.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AAGATCCTGTGGAAAAAACTC	0.512													17	70					0	0	0.001882	0	0
RUNX2	860	broad.mit.edu	37	6	45480082	45480082	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:45480082C>T	uc011dvx.1	+	7	1169	c.959C>T	c.(958-960)CCG>CTG	p.P320L	RUNX2_uc011dvy.1_Missense_Mutation_p.P320L|RUNX2_uc003oxt.2_Missense_Mutation_p.P306L	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	320	Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						TCTACCACCCCGCTGTCTTCC	0.587													27	110					0	0	0.005443	0	0
RUNX2	860	broad.mit.edu	37	6	45514872	45514872	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:45514872C>T	uc011dvx.1	+	9	1606	c.1396C>T	c.(1396-1398)CCT>TCT	p.P466S	RUNX2_uc011dvy.1_Missense_Mutation_p.P444S|RUNX2_uc003oxt.2_Missense_Mutation_p.P452S	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	466	Pro/Ser/Thr-rich.|Interaction with MYST4.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.P466L(1)		ovary(2)|skin(1)	3						AGACCGGTCTCCTTCCAGAAT	0.532													18	90					0	0	0.004990	0	0
TDRD6	221400	broad.mit.edu	37	6	46660298	46660298	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46660298C>T	uc003oyj.2	+	1	4433	c.4433C>T	c.(4432-4434)GCT>GTT	p.A1478V	TDRD6_uc010jze.2_Missense_Mutation_p.A1472V	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1478					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AGCAGGTATGCTCTCAGTGAA	0.348													24	111					0	0	0.003330	0	0
TDRD6	221400	broad.mit.edu	37	6	46665773	46665773	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46665773C>T	uc003oyj.2	+	3	6210	c.6210C>T	c.(6208-6210)AAC>AAT	p.N2070N	TDRD6_uc010jze.2_Intron	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	2070	Tudor 8.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AGATAGTGAACCCTGAGAATG	0.338													49	297					0	0	0.003610	0	0
MEP1A	4224	broad.mit.edu	37	6	46787321	46787321	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46787321G>A	uc010jzh.1	+	7	478	c.436G>A	c.(436-438)GGA>AGA	p.G146R	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Missense_Mutation_p.G174R|MEP1A_uc011dwi.1_Missense_Mutation_p.G46R	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	146	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			CATTGGCCAAGGATGTGCCTA	0.443													35	134					0	0	0.002445	0	0
MEP1A	4224	broad.mit.edu	37	6	46787396	46787396	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46787396G>A	uc010jzh.1	+	7	553	c.511G>A	c.(511-513)GAC>AAC	p.D171N	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Missense_Mutation_p.D199N|MEP1A_uc011dwi.1_Missense_Mutation_p.D71N	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	171	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			GTCAAGGACGGACCGGGATGA	0.478													50	311					0	0	0.003610	0	0
GPR110	266977	broad.mit.edu	37	6	46996787	46996788	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46996787_46996788CC>TT	uc003oyt.2	-	2	209_210	c.10_11GG>AA	c.(10-12)GGA>AAA	p.G4K	GPR110_uc011dwl.1_5'UTR|GPR110_uc003oyu.1_Missense_Mutation_p.G4K	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	4					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CCACAGCACTCCAACTTTCATT	0.48													17	58					0	0	0.004672	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47202494	47202494	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:47202494G>A	uc003oyv.2	-	5	2083	c.1650C>T	c.(1648-1650)TTC>TTT	p.F550F		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	550	Cytoplasmic (Potential).				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			ACTCATCCACGAAGAAGCCCT	0.483													4	22					0	0	0.000602	0	0
CD2AP	23607	broad.mit.edu	37	6	47576991	47576991	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:47576991C>T	uc003oyw.2	+	16	2221	c.1765C>T	c.(1765-1767)CAG>TAG	p.Q589*		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	589	Potential.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			ACTTAGAGCCCAGATTATTGA	0.378													27	123					0	0	0.006320	0	0
GPR111	222611	broad.mit.edu	37	6	47649845	47649845	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:47649845G>A	uc010jzj.1	+	6	1551	c.1550G>A	c.(1549-1551)GGA>GAA	p.G517E	GPR111_uc010jzk.1_Missense_Mutation_p.G449E|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	517	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CACCACAAGGGATGTGTGGCA	0.433													19	60					0	0	0.006122	0	0
GPR115	221393	broad.mit.edu	37	6	47680130	47680130	+	Missense_Mutation	SNP	C	T	T	rs149916768	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:47680130C>T	uc003oza.1	+	5	596	c.338C>T	c.(337-339)CCA>CTA	p.P113L	GPR115_uc003oyz.1_Missense_Mutation_p.P170L|GPR115_uc003ozb.1_Missense_Mutation_p.P111L	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	113	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						GTAGCAGCACCATCTATACCT	0.413													26	207					0	0	0.006320	0	0
PGK2	5232	broad.mit.edu	37	6	49754364	49754364	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:49754364C>T	uc003ozu.2	-	1	644	c.537G>A	c.(535-537)GTG>GTA	p.V179V		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	179					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					GGGGCAGATTCACTCCCACCA	0.468													20	78					0	0	0.001882	0	0
ICK	22858	broad.mit.edu	37	6	52869951	52869951	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:52869951C>T	uc003pbh.2	-	15	2385	c.1895G>A	c.(1894-1896)CGA>CAA	p.R632Q	ICK_uc003pbi.2_Missense_Mutation_p.R632Q	NM_016513	NP_057597	Q9UPZ9	ICK_HUMAN	intestinal cell kinase	632					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			ovary(1)|large_intestine(1)|lung(1)|kidney(1)|central_nervous_system(1)	5	Lung NSC(77;0.103)					AGACAGTCATCGCCGAGATGC	0.567													27	161					0	0	0.001786	0	0
ICK	22858	broad.mit.edu	37	6	52874239	52874239	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:52874239G>A	uc003pbh.2	-	13	2109	c.1619C>T	c.(1618-1620)TCA>TTA	p.S540L	ICK_uc003pbi.2_Missense_Mutation_p.S540L	NM_016513	NP_057597	Q9UPZ9	ICK_HUMAN	intestinal cell kinase	540					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			ovary(1)|large_intestine(1)|lung(1)|kidney(1)|central_nervous_system(1)	5	Lung NSC(77;0.103)					TTACTCACCTGAATTTACTTT	0.448													21	145					0	0	0.002780	0	0
LRRC1	55227	broad.mit.edu	37	6	53707025	53707025	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:53707025G>A	uc003pcd.1	+	2	554	c.277G>A	c.(277-279)GAG>AAG	p.E93K		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	93	LRR 4.					cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		GTCTCGAAATGGTAAGAAAGA	0.348													34	152					0	0	0.003755	0	0
FAM83B	222584	broad.mit.edu	37	6	54806377	54806377	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:54806377C>T	uc003pck.2	+	5	2724	c.2608C>T	c.(2608-2610)CCA>TCA	p.P870S		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	870										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					AACACCTTCTCCAGGTCCAGT	0.433													13	70					0	0	0.002450	0	0
DST	667	broad.mit.edu	37	6	56335074	56335074	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:56335074G>A	uc003pdf.2	-	90	15999	c.15971C>T	c.(15970-15972)CCA>CTA	p.P5324L	DST_uc003pcz.3_Missense_Mutation_p.P5146L|DST_uc011dxj.1_Missense_Mutation_p.P5175L|DST_uc011dxk.1_Missense_Mutation_p.P5186L|DST_uc003pcy.3_Missense_Mutation_p.P4820L|DST_uc003pcw.3_5'Flank|DST_uc003pcx.3_5'Flank	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7232	EF-hand 1.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GCGACTGGTTGGAAACTCTAA	0.388													5	29					0	0	0.001168	0	0
BAI3	577	broad.mit.edu	37	6	69772857	69772857	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:69772857G>A	uc003pev.3	+	16	2813	c.2365G>A	c.(2365-2367)GTG>ATG	p.V789M	BAI3_uc010kak.2_Missense_Mutation_p.V789M	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	789	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CAAAATCATCGTGGTCACAAT	0.368													31	2					0	0	0.002836	0	0
COL12A1	1303	broad.mit.edu	37	6	75858113	75858113	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:75858113C>T	uc003phs.2	-	22	4414	c.4248G>A	c.(4246-4248)AAG>AAA	p.K1416K	COL12A1_uc003pht.2_Silent_p.K252K	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1416	Fibronectin type-III 9.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						AGTATTCCACCTTATATCGAT	0.433													18	20					0	0	0.004990	0	0
FILIP1	27145	broad.mit.edu	37	6	76022585	76022585	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:76022585C>T	uc003pia.2	-	5	3336	c.2963G>A	c.(2962-2964)AGA>AAA	p.R988K	FILIP1_uc003phy.1_Missense_Mutation_p.R988K|FILIP1_uc003phz.2_Missense_Mutation_p.R889K|FILIP1_uc010kbe.2_Missense_Mutation_p.R991K|FILIP1_uc003pib.1_Missense_Mutation_p.R740K	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	988										skin(3)|ovary(1)	4						AGTCTTCTCTCTGGAAAATGT	0.463													26	38					0	0	0.004656	0	0
MYO6	4646	broad.mit.edu	37	6	76551093	76551093	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:76551093C>T	uc003pih.1	+	9	1093	c.814C>T	c.(814-816)CGG>TGG	p.R272W	MYO6_uc003pig.1_Missense_Mutation_p.R272W|MYO6_uc003pii.1_Missense_Mutation_p.R272W	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	272	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AGATAATTTTCGGGTAGGTCA	0.214													13	21					0	0	0.001368	0	0
DOPEY1	23033	broad.mit.edu	37	6	83810447	83810448	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:83810447_83810448CC>TT	uc003pjs.1	+	4	422_423	c.162_163CC>TT	c.(160-165)TACCAA>TATTAA	p.Q55*	DOPEY1_uc011dyy.1_Nonsense_Mutation_p.Q55*|DOPEY1_uc010kbl.1_Nonsense_Mutation_p.Q55*	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	55					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		ATGCAAAGTACCAAGTAGTACC	0.361													44	71					0	0	0.004672	0	0
PRSS35	167681	broad.mit.edu	37	6	84234162	84234162	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:84234162C>T	uc003pjz.2	+	2	1165	c.1002C>T	c.(1000-1002)CTC>CTT	p.L334L	PRSS35_uc010kbm.2_Silent_p.L334L	NM_153362	NP_699193	Q8N3Z0	PRS35_HUMAN	protease, serine, 35 precursor	334	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		CCAATGATCTCCTTTACCAAT	0.473													37	39					0	0	0.006999	0	0
C6orf165	154313	broad.mit.edu	37	6	88144610	88144610	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:88144610G>A	uc003plv.2	+	11	1425	c.1333G>A	c.(1333-1335)GAA>AAA	p.E445K	SLC35A1_uc003plx.2_5'Flank|C6orf165_uc003plw.2_Missense_Mutation_p.E257K|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Missense_Mutation_p.E445K	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	445										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AAAATATAAAGAAAAATATTA	0.239													5	13					0	0	0.000602	0	0
RARS2	57038	broad.mit.edu	37	6	88227908	88227908	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:88227908G>A	uc003pme.2	-	17	1550	c.1490C>T	c.(1489-1491)TCA>TTA	p.S497L	RARS2_uc003pmb.2_Missense_Mutation_p.S322L|RARS2_uc003pmc.2_Missense_Mutation_p.S322L|RARS2_uc003pmd.2_Missense_Mutation_p.S134L|RARS2_uc003pmf.2_RNA	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	497					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		CTGAAGAATTGAAACAGACTG	0.383													29	60					0	0	0.003271	0	0
GABRR1	2569	broad.mit.edu	37	6	89910935	89910935	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:89910935A>T	uc003pna.2	-	3	678	c.223T>A	c.(223-225)TCA>ACA	p.S75T	GABRR1_uc011dzv.1_Missense_Mutation_p.S52T	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	75	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	AGCTGTTCTGACTTTGTCAGA	0.488													28	49					0	0	0.001786	0	0
MDN1	23195	broad.mit.edu	37	6	90397860	90397860	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:90397860G>A	uc003pnn.1	-	67	11408	c.11292C>T	c.(11290-11292)TTC>TTT	p.F3764F		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3764					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TGGAAAGTGGGAAACTACGAA	0.443													89	99					0	0	0.003610	0	0
BACH2	60468	broad.mit.edu	37	6	90660621	90660621	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:90660621C>T	uc011eab.1	-	7	2013	c.1204G>A	c.(1204-1206)GTG>ATG	p.V402M	BACH2_uc003pnw.2_Missense_Mutation_p.V402M|BACH2_uc010kch.2_Missense_Mutation_p.V402M	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	402						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		AAGTTGGACACCTCCTTCTGG	0.582													17	19					0	0	0.007413	0	0
ASCC3	10973	broad.mit.edu	37	6	101296463	101296463	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:101296463G>A	uc003pqk.2	-	4	691	c.362C>T	c.(361-363)CCC>CTC	p.P121L	ASCC3_uc011eai.1_Missense_Mutation_p.P23L|ASCC3_uc003pql.2_Missense_Mutation_p.P121L|ASCC3_uc010kcv.2_Missense_Mutation_p.P121L	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TGAAGGAAAGGGGCCAAACAT	0.408													20	14					0	0	0.008871	0	0
PRDM1	639	broad.mit.edu	37	6	106552934	106552934	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:106552934C>T	uc003prd.2	+	5	1133	c.899C>T	c.(898-900)CCC>CTC	p.P300L	PRDM1_uc003pre.2_Missense_Mutation_p.P166L	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	300					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		GTCGTTTACCCCATCCGGGCC	0.552			D|N|Mis|F|S		DLBCL								44	64					0	0	0.008740	0	0
ARMC2	84071	broad.mit.edu	37	6	109274522	109274522	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:109274522C>T	uc003pss.3	+	13	2057	c.1883C>T	c.(1882-1884)CCG>CTG	p.P628L	ARMC2_uc011eao.1_Missense_Mutation_p.P463L	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	628	ARM 9.						binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		GCCGCCAACCCGGGGATAGTG	0.652													9	14					0	0	0.004482	0	0
FIG4	9896	broad.mit.edu	37	6	110113863	110113863	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:110113863T>C	uc003ptt.2	+	21	2670	c.2455T>C	c.(2455-2457)TCA>CCA	p.S819P	FIG4_uc011eau.1_Missense_Mutation_p.S542P	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	819					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CTCCATTTATTCAAGGTGAGA	0.284													14	20					0	0	0.003163	0	0
REV3L	5980	broad.mit.edu	37	6	111632369	111632369	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:111632369C>T	uc003puy.3	-	29	9021	c.8698G>A	c.(8698-8700)GGA>AGA	p.G2900R	REV3L_uc003pux.3_Missense_Mutation_p.G2822R|REV3L_uc003puz.3_Missense_Mutation_p.G2822R|REV3L_uc003pva.1_RNA|REV3L_uc003puw.3_5'Flank	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2900					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTGGCCTTTCCTTCCAGAAGC	0.383								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					50	123					0	0	0.003610	0	0
TUBE1	51175	broad.mit.edu	37	6	112397626	112397626	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:112397626G>A	uc003pvq.2	-	7	649	c.535C>T	c.(535-537)CCT>TCT	p.P179S	TUBE1_uc003pvr.2_Missense_Mutation_p.P104S	NM_016262	NP_057346	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	179					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			ovary(1)	1		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TCACCAGAAGGATAAATGGAA	0.398													26	20					0	0	0.003954	0	0
HSF2	3298	broad.mit.edu	37	6	122743417	122743417	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:122743417T>G	uc003pyu.2	+	8	991	c.804T>G	c.(802-804)AAT>AAG	p.N268K	HSF2_uc003pyv.2_Missense_Mutation_p.N268K	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	268					response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		CAGAAACTAATGAGGATGTTA	0.308													60	96					0	0	0.003610	0	0
PTPRK	5796	broad.mit.edu	37	6	128306886	128306886	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:128306886G>A	uc003qbk.2	-	22	3595	c.3228C>T	c.(3226-3228)GGC>GGT	p.G1076G	PTPRK_uc003qbj.2_Silent_p.G1077G|PTPRK_uc010kfc.2_Silent_p.G1083G|PTPRK_uc011ebu.1_Silent_p.G1099G	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1076	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CAACGATGGGGCCAGCACTGG	0.483													17	24					0	0	0.004007	0	0
OR2A4	79541	broad.mit.edu	37	6	132022493	132022493	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:132022493G>A	uc011ecd.1	-	1	49	c.49C>T	c.(49-51)CCC>TCC	p.P17S	ENPP3_uc003qcu.3_Intron|ENPP3_uc010kfq.2_Intron|ENPP3_uc003qcv.2_Intron	NM_030908	NP_112170	O95047	OR2A4_HUMAN	olfactory receptor, family 2, subfamily A,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.018)|OV - Ovarian serous cystadenocarcinoma(155;0.041)		GGGCCAACGGGAAATCCCAGT	0.488													19	28					0	0	0.003330	0	0
TAAR8	83551	broad.mit.edu	37	6	132874354	132874354	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:132874354G>A	uc011ecj.1	+	1	523	c.523G>A	c.(523-525)GGG>AGG	p.G175R		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	175	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		CAATGATGATGGGCTGGAGGA	0.468													61	94					0	0	0.003610	0	0
PDE7B	27115	broad.mit.edu	37	6	136429878	136429878	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:136429878G>A	uc003qgp.2	+	3	395	c.92G>A	c.(91-93)CGA>CAA	p.R31Q	uc003qgq.1_Intron|PDE7B_uc003qgr.2_Missense_Mutation_p.R83Q	NM_018945	NP_061818	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	31					signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(1)	1	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	GGAGATATACGACTAAGGGGT	0.463													39	42					0	0	0.006230	0	0
SLC35D3	340146	broad.mit.edu	37	6	137245365	137245365	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:137245365T>G	uc003qhe.2	+	2	947	c.782T>G	c.(781-783)GTG>GGG	p.V261G		NM_001008783	NP_001008783	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	261	Helical; (Potential).				carbohydrate transport	integral to membrane				ovary(1)|central_nervous_system(1)	2	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		GTGGGTGTGGTGAAGAGCATC	0.607													5	16					0	0	0.000602	0	0
HIVEP2	3097	broad.mit.edu	37	6	143074685	143074685	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:143074685G>A	uc003qjd.2	-	10	7643	c.6900C>T	c.(6898-6900)TCC>TCT	p.S2300S		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	2300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GCCGAGGAGAGGAGGGAGTGC	0.517													23	40					0	0	0.004656	0	0
HIVEP2	3097	broad.mit.edu	37	6	143091889	143091889	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:143091889G>A	uc003qjd.2	-	5	4730	c.3987C>T	c.(3985-3987)CTC>CTT	p.L1329L		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CTGTTCCTGGGAGGGACTGCA	0.498													28	20					0	0	0.005443	0	0
UTRN	7402	broad.mit.edu	37	6	144852338	144852338	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:144852338G>A	uc003qkt.2	+	41	6149	c.6057G>A	c.(6055-6057)CAG>CAA	p.Q2019Q		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2019	Spectrin 14.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TACATCAGCAGGTGAGTGCTT	0.443													10	11					0	0	0.001855	0	0
GRM1	2911	broad.mit.edu	37	6	146720176	146720176	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:146720176C>T	uc010khw.1	+	8	2471	c.2001C>T	c.(1999-2001)TCC>TCT	p.S667S	GRM1_uc010khv.1_Silent_p.S667S|GRM1_uc003qll.2_Silent_p.S667S|GRM1_uc011edz.1_Silent_p.S667S|GRM1_uc011eea.1_Silent_p.S667S	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	667	Helical; Name=3; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TTGGCCTCTCCTCTGCGATGT	0.527													88	127					0	0	0.003610	0	0
ULBP2	80328	broad.mit.edu	37	6	150266536	150266536	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:150266536G>A	uc003qno.2	+	2	250	c.177G>A	c.(175-177)AAG>AAA	p.K59K	ULBP2_uc011eeh.1_Silent_p.K59K|ULBP2_uc010kij.2_Silent_p.K59K	NM_025217	NP_079493	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2 precursor	59	MHC class I alpha-1 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		TGGATGAAAAGACTTTTCTTC	0.512													37	43					0	0	0.002222	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151206843	151206843	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:151206843G>A	uc003qob.2	+	6	884	c.616G>A	c.(616-618)GCT>ACT	p.A206T	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Missense_Mutation_p.A206T|MTHFD1L_uc003qoc.2_Missense_Mutation_p.A153T|MTHFD1L_uc003qoa.1_Missense_Mutation_p.A206T|MTHFD1L_uc010kil.1_RNA	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	206	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		TGTTGCCAAAGCTGTAATTGA	0.368													29	42					0	0	0.006320	0	0
C6orf97	80129	broad.mit.edu	37	6	151917610	151917610	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:151917610G>A	uc003qol.2	+	9	1697	c.1608G>A	c.(1606-1608)AGG>AGA	p.R536R		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	536	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		TTACCATCAGGAACTTGCAGA	0.557													24	39					0	0	0.002780	0	0
SYNE1	23345	broad.mit.edu	37	6	152725395	152725395	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:152725395C>A	uc010kiw.2	-	46	7380	c.6778G>T	c.(6778-6780)GAT>TAT	p.D2260Y	SYNE1_uc003qot.3_Missense_Mutation_p.D2267Y|SYNE1_uc003qou.3_Missense_Mutation_p.D2260Y|SYNE1_uc010kjb.1_Missense_Mutation_p.D2243Y	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2260	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCTTTCAGATCATTAACTTTG	0.338										HNSCC(10;0.0054)			23	46					1.5548e-18	2.3761e-18	0.005443	1	0
RBM16	22828	broad.mit.edu	37	6	155114102	155114102	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:155114102A>C	uc003qqa.2	+	6	699	c.467A>C	c.(466-468)AAT>ACT	p.N156T	RBM16_uc011efj.1_Missense_Mutation_p.N222T|RBM16_uc011efk.1_Missense_Mutation_p.N201T|RBM16_uc003qpz.2_Missense_Mutation_p.N156T|RBM16_uc010kji.2_Missense_Mutation_p.N177T	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	156					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		GCTATGAGCAATACTCCAGGT	0.398													18	23					0	0	0.001523	0	0
SNX9	51429	broad.mit.edu	37	6	158342637	158342637	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:158342637C>T	uc003qqv.1	+	10	1197	c.1024C>T	c.(1024-1026)CCA>TCA	p.P342S		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	342	PX.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		GTGTCGCCATCCAGTAATCTC	0.443													24	27					0	0	0.007291	0	0
GPR31	2853	broad.mit.edu	37	6	167570376	167570376	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:167570376C>T	uc011egq.1	-	1	944	c.944G>A	c.(943-945)AGA>AAA	p.R315K		NM_005299	NP_005290	O00270	GPR31_HUMAN	G protein-coupled receptor 31	315	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		ATAGGAGTCTCTGGGGTTGAA	0.537													12	19					0	0	0.002450	0	0
TTLL2	83887	broad.mit.edu	37	6	167753716	167753716	+	Nonsense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:167753716A>T	uc003qvs.1	+	3	416	c.328A>T	c.(328-330)AAG>TAG	p.K110*	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	110	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GGGGTGGAATAAGTTTGATAA	0.552													14	10					0	0	0.001855	0	0
TTLL2	83887	broad.mit.edu	37	6	167755030	167755030	+	Missense_Mutation	SNP	G	A	A	rs111648937		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:167755030G>A	uc003qvs.1	+	3	1730	c.1642G>A	c.(1642-1644)GCT>ACT	p.A548T	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	548					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CCGTGGCAAAGCTCCAGATCC	0.507													32	43					0	0	0.003755	0	0
PRKAR1B	5575	broad.mit.edu	37	7	590155	590155	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:590155G>A	uc003siu.1	-	12	1164	c.1058C>T	c.(1057-1059)CCC>CTC	p.P353L	PRKAR1B_uc003siv.2_Missense_Mutation_p.P353L|PRKAR1B_uc003siw.1_Missense_Mutation_p.P353L	NM_002735	NP_002726	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type	353	cAMP 2.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		CTCGAAGCGGGGCCGGTCCAG	0.642													8	13					0	0	0.003080	0	0
PRKAR1B	5575	broad.mit.edu	37	7	751017	751017	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:751017C>T	uc003siu.1	-	3	232	c.126G>A	c.(124-126)AAG>AAA	p.K42K	PRKAR1B_uc003siv.2_Silent_p.K42K|PRKAR1B_uc003siw.1_Silent_p.K42K	NM_002735	NP_002726	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type	42	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		GGCGTTCGGGCTTGGAGATGC	0.637													10	109					0	0	0.006214	0	0
CYP2W1	54905	broad.mit.edu	37	7	1024668	1024668	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:1024668G>A	uc003sjq.1	+	3	433	c.420G>A	c.(418-420)CGG>CGA	p.R140R	CYP2W1_uc003sjr.1_Silent_p.R140R	NM_017781	NP_060251	Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W,	140					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GCGTGGGCCGGGAGCCGGTGG	0.672													9	74					0	0	0.004482	0	0
C7orf50	84310	broad.mit.edu	37	7	1037314	1037314	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:1037314G>A	uc003sju.2	-	5	602	c.532C>T	c.(532-534)CCC>TCC	p.P178S	C7orf50_uc003sjs.2_RNA|C7orf50_uc011jvt.1_Missense_Mutation_p.P178S|C7orf50_uc011jvu.1_Missense_Mutation_p.P178S	NM_032350	NP_115726	Q9BRJ6	CG050_HUMAN	hypothetical protein LOC84310	178							protein binding				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		CCCGGCAGGGGGGGATCAGAG	0.721													34	34					0	0	0.002836	0	0
GPR146	115330	broad.mit.edu	37	7	1097763	1097763	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:1097763C>T	uc003sjw.2	+	2	688	c.612C>T	c.(610-612)CTC>CTT	p.L204L	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPR146_uc003sjx.3_Silent_p.L204L|GPR146_uc003sjy.1_Silent_p.L204L	NM_138445	NP_612454	Q96CH1	GP146_HUMAN	G protein-coupled receptor 146	204	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		TGGCCACCCTCTACGCGCTGG	0.692													4	25					0	0	0.000248	0	0
INTS1	26173	broad.mit.edu	37	7	1516462	1516462	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:1516462G>A	uc003skn.2	-	36	5132	c.5031C>T	c.(5029-5031)ATC>ATT	p.I1677I	INTS1_uc003skm.1_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1677					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GCAGGACTCGGATGCACTGGT	0.657													10	76					0	0	0.001368	0	0
INTS1	26173	broad.mit.edu	37	7	1522326	1522326	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:1522326G>A	uc003skn.2	-	27	3660	c.3559C>T	c.(3559-3561)CAG>TAG	p.Q1187*	INTS1_uc003skp.1_3'UTR	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1187					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		AGCAGCGCCTGGAACTCGCTG	0.647													26	251					0	0	0.007291	0	0
MAD1L1	8379	broad.mit.edu	37	7	2108866	2108866	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2108866G>A	uc003slh.1	-	12	1447	c.1181C>T	c.(1180-1182)GCC>GTC	p.A394V	MAD1L1_uc003sle.1_Missense_Mutation_p.A123V|MAD1L1_uc003slf.1_Missense_Mutation_p.A394V|MAD1L1_uc003slg.1_Missense_Mutation_p.A394V|MAD1L1_uc010ksh.1_Missense_Mutation_p.A394V|MAD1L1_uc003sli.1_Missense_Mutation_p.A302V|MAD1L1_uc010ksi.1_Missense_Mutation_p.A347V|MAD1L1_uc010ksj.2_Missense_Mutation_p.A394V	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	394	Necessary for interaction with NEK2.|Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		GAGCCTCCGGGCCAGCGCCTC	0.642													23	157					0	0	0.001786	0	0
FTSJ2	29960	broad.mit.edu	37	7	2274925	2274925	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2274925G>A	uc003slm.2	-	3	602	c.573C>T	c.(571-573)TTC>TTT	p.F191F	MAD1L1_uc003slh.1_5'Flank|MAD1L1_uc003slf.1_5'Flank|MAD1L1_uc003slg.1_5'Flank|MAD1L1_uc010ksh.1_5'Flank|MAD1L1_uc003sli.1_5'Flank|MAD1L1_uc010ksi.1_5'Flank|MAD1L1_uc010ksj.2_5'Flank|FTSJ2_uc003slk.2_Silent_p.F37F|FTSJ2_uc003sll.2_Silent_p.F37F|FTSJ2_uc003sln.2_RNA|FTSJ2_uc003slo.2_Silent_p.F37F	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	FtsJ homolog 2	191					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		TTTTACAAAGGAATGTCCCCC	0.542													13	153					0	0	0.002450	0	0
SNX8	29886	broad.mit.edu	37	7	2297013	2297013	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2297013G>A	uc003slw.2	-	9	1164	c.1121C>T	c.(1120-1122)TCC>TTC	p.S374F		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	374					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CACAATGCGGGACTCCAGCTG	0.701													8	22					0	0	0.006214	0	0
EIF3B	8662	broad.mit.edu	37	7	2412389	2412389	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2412389C>T	uc003slx.2	+	12	1852	c.1769C>T	c.(1768-1770)TCT>TTT	p.S590F	EIF3B_uc003sly.2_Missense_Mutation_p.S590F|EIF3B_uc003sma.2_Missense_Mutation_p.S318F	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	590	WD 4.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		ATATCTGTGTCTTTCTACCAC	0.468													7	130					0	0	0.001984	0	0
EIF3B	8662	broad.mit.edu	37	7	2412393	2412393	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2412393C>T	uc003slx.2	+	12	1856	c.1773C>T	c.(1771-1773)TTC>TTT	p.F591F	EIF3B_uc003sly.2_Silent_p.F591F|EIF3B_uc003sma.2_Silent_p.F319F	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	591	WD 4.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CTGTGTCTTTCTACCACGTCA	0.473													6	134					0	0	0.001168	0	0
CHST12	55501	broad.mit.edu	37	7	2473276	2473276	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2473276C>T	uc003smc.2	+	2	1137	c.1002C>T	c.(1000-1002)ATC>ATT	p.I334I	CHST12_uc003smd.2_Silent_p.I334I	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	334	Lumenal (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CGTGCCAGATCGACTACGACT	0.657													10	101					0	0	0.008291	0	0
AMZ1	155185	broad.mit.edu	37	7	2752035	2752035	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2752035G>A	uc003smr.1	+	7	1381	c.1020G>A	c.(1018-1020)TGG>TGA	p.W340*	AMZ1_uc003sms.1_Missense_Mutation_p.G284R|AMZ1_uc011jwa.1_Nonsense_Mutation_p.W89*	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	340							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CGTCAGTGTGGGAGGACACCC	0.667													4	34					0	0	0.000248	0	0
CARD11	84433	broad.mit.edu	37	7	2946340	2946340	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2946340G>A	uc003smv.2	-	25	3801	c.3397C>T	c.(3397-3399)CGC>TGC	p.R1133C		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	1133	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTGACAACGCGGAGCAGCTCC	0.662			Mis		DLBCL								22	104					0	0	0.001882	0	0
CARD11	84433	broad.mit.edu	37	7	2963889	2963889	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2963889A>G	uc003smv.2	-	15	2322	c.1918T>C	c.(1918-1920)TTC>CTC	p.F640L		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	640					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		AACTTCCTGAACATGAGGTTG	0.592			Mis		DLBCL								9	97					0	0	0.004482	0	0
CARD11	84433	broad.mit.edu	37	7	2987262	2987262	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2987262T>A	uc003smv.2	-	3	571	c.167A>T	c.(166-168)GAT>GTT	p.D56V		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	56	CARD.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTCATCTTCATCCTGCTCATC	0.547			Mis		DLBCL								28	208					0	0	0.002096	0	0
SDK1	221935	broad.mit.edu	37	7	4185409	4185409	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4185409G>A	uc003smx.2	+	29	4423	c.4284G>A	c.(4282-4284)GTG>GTA	p.V1428V	SDK1_uc010kso.2_Silent_p.V704V|SDK1_uc003smy.2_5'UTR	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1428	Fibronectin type-III 8.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TCACCACCGTGGAGGTCGGCG	0.662													25	193					0	0	0.005443	0	0
SDK1	221935	broad.mit.edu	37	7	4273011	4273011	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4273011G>A	uc003smx.2	+	41	6091	c.5952G>A	c.(5950-5952)GCG>GCA	p.A1984A	SDK1_uc010kso.2_Silent_p.A1240A|SDK1_uc003smy.2_Silent_p.A471A|SDK1_uc003smz.2_Silent_p.A44A	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1984	Fibronectin type-III 13.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGAATGAGGCGGGCTACGGGG	0.617													17	154					0	0	0.007413	0	0
SDK1	221935	broad.mit.edu	37	7	4277403	4277403	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4277403G>A	uc003smx.2	+	42	6256	c.6117G>A	c.(6115-6117)AAG>AAA	p.K2039K	SDK1_uc010kso.2_Silent_p.K1295K|SDK1_uc003smy.2_Silent_p.K526K|SDK1_uc003smz.2_Silent_p.K99K	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	2039	Extracellular (Potential).|Cytoplasmic (Potential).				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGAAGTATAAGAACTGCAGCA	0.592													20	166					0	0	0.002780	0	0
RADIL	55698	broad.mit.edu	37	7	4856006	4856006	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4856006C>T	uc003snj.1	-	8	1992	c.1819G>A	c.(1819-1821)GAG>AAG	p.E607K	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Missense_Mutation_p.E112K|RADIL_uc011jwc.1_Missense_Mutation_p.E367K|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	607	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CGCAGCTCCTCGGGCAGTTCG	0.701													40	65					0	0	0.002522	0	0
RADIL	55698	broad.mit.edu	37	7	4856095	4856095	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4856095G>A	uc003snj.1	-	8	1903	c.1730C>T	c.(1729-1731)TCC>TTC	p.S577F	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Missense_Mutation_p.S82F|RADIL_uc011jwc.1_Missense_Mutation_p.S337F|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	577	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GATGTACAGGGACTGGCGGGG	0.692													10	103					0	0	0.008291	0	0
RADIL	55698	broad.mit.edu	37	7	4917288	4917288	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4917288C>G	uc003snj.1	-	2	656	c.483G>C	c.(481-483)AAG>AAC	p.K161N	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	161	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CGTCCGACCTCTTCCTCAGCT	0.602													21	297					0	0	0.008871	0	0
TNRC18	84629	broad.mit.edu	37	7	5391481	5391481	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:5391481G>A	uc003soi.3	-	17	5788	c.5439C>T	c.(5437-5439)TTC>TTT	p.F1813F	TNRC18_uc003soj.2_Silent_p.F195F	NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1813							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AAGAGTCGCTGAAGGAGGAAC	0.597													7	71					0	0	0.004482	0	0
FBXL18	80028	broad.mit.edu	37	7	5541201	5541201	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:5541201G>A	uc003soo.2	-	3	793	c.699C>T	c.(697-699)TTC>TTT	p.F233F	FBXL18_uc003son.3_Silent_p.F233F	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	233										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GGCGCGCATAGAAGACCCGCA	0.642													8	138					0	0	0.003080	0	0
FSCN1	6624	broad.mit.edu	37	7	5633104	5633104	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:5633104C>T	uc003sou.2	+	1	651	c.537C>T	c.(535-537)CTC>CTT	p.L179L		NM_003088	NP_003079	Q16658	FSCN1_HUMAN	fascin 1	179					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			ovary(1)	1		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		TCATCACCCTCGCCTTCCAGG	0.736													23	92					0	0	0.003954	0	0
RNF216	54476	broad.mit.edu	37	7	5764962	5764962	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:5764962A>T	uc003soy.1	-	8	1516	c.1326T>A	c.(1324-1326)TTT>TTA	p.F442L	RNF216_uc010ksz.1_Missense_Mutation_p.F64L|RNF216_uc010kta.1_Missense_Mutation_p.F64L|RNF216_uc011jwj.1_Missense_Mutation_p.F64L|RNF216_uc003sox.1_Missense_Mutation_p.F499L	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	442					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TACCTTGTTCAAACTTGAAAT	0.423													12	246					0	0	0.001368	0	0
PMS2	5395	broad.mit.edu	37	7	6027010	6027010	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:6027010G>A	uc003spl.2	-	11	1473	c.1386C>T	c.(1384-1386)ATC>ATT	p.I462I	PMS2_uc003spj.2_Silent_p.I356I|PMS2_uc003spk.2_Silent_p.I327I|PMS2_uc011jwl.1_Silent_p.I327I|PMS2_uc010ktg.2_Silent_p.I151I|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Silent_p.I462I	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	462					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CTTTGTCAGAGATGGCACCTG	0.557			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				21	341					0	0	0.002780	0	0
CYTH3	9265	broad.mit.edu	37	7	6210259	6210259	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:6210259T>A	uc003spt.2	-	9	834	c.730A>T	c.(730-732)AAG>TAG	p.K244*	CYTH3_uc011jws.1_Nonsense_Mutation_p.K159*	NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3	244					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						GGCTCGTTCTTAATGCTCTCA	0.582													8	94					0	0	0.004482	0	0
RAC1	5879	broad.mit.edu	37	7	6439791	6439791	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:6439791C>T	uc003spx.2	+	4	501	c.260C>T	c.(259-261)CCT>CTT	p.P87L	RAC1_uc003spw.2_Missense_Mutation_p.P106L	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	87					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	CTTGTGAGTCCTGCATCATTT	0.343													27	462					0	0	0.008361	0	0
COL28A1	340267	broad.mit.edu	37	7	7457497	7457497	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:7457497C>T	uc003src.1	-	27	2246	c.2129G>A	c.(2128-2130)GGA>GAA	p.G710E	COL28A1_uc011jxe.1_Missense_Mutation_p.G393E|COL28A1_uc003srd.2_Missense_Mutation_p.G265E	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	710					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TACTTTAATTCCCTGTGATCC	0.463													17	177					0	0	0.007413	0	0
COL28A1	340267	broad.mit.edu	37	7	7472283	7472283	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:7472283C>T	uc003src.1	-	24	2026	c.1909G>A	c.(1909-1911)GAT>AAT	p.D637N	COL28A1_uc011jxe.1_Missense_Mutation_p.D320N|COL28A1_uc003srd.2_Missense_Mutation_p.D192N|COL28A1_uc003sre.1_Missense_Mutation_p.D58N	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	637					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GGATAGCCATCACCTTTGAGT	0.493													15	272					0	0	0.006122	0	0
COL28A1	340267	broad.mit.edu	37	7	7480434	7480434	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:7480434G>A	uc003src.1	-	21	1826	c.1709C>T	c.(1708-1710)CCC>CTC	p.P570L	COL28A1_uc011jxe.1_Missense_Mutation_p.P253L|COL28A1_uc003srd.2_Missense_Mutation_p.P125L	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	570	Collagen-like 5.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TGGTCCTTCGGGCCCTGGAAG	0.373													26	137					0	0	0.007291	0	0
THSD7A	221981	broad.mit.edu	37	7	11468645	11468645	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:11468645G>A	uc003ssf.3	-	14	3424	c.3172C>T	c.(3172-3174)CGT>TGT	p.R1058C		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1058	TSP type-1 11.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CATTTAGAACGAACCTTCACA	0.512										HNSCC(18;0.044)			48	174					0	0	0.003610	0	0
TMEM195	392636	broad.mit.edu	37	7	15240949	15240949	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:15240949A>G	uc003stb.1	-	13	1469	c.1299T>C	c.(1297-1299)GTT>GTC	p.V433V		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	433	Helical; (Potential).				ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TCATGCTTCTAACTCCCCAGA	0.333													40	50					0	0	0.003610	0	0
ANKMY2	57037	broad.mit.edu	37	7	16649313	16649313	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:16649313G>A	uc003sti.2	-	7	1024	c.824C>T	c.(823-825)CCT>CTT	p.P275L	ANKMY2_uc010ktz.2_RNA	NM_020319	NP_064715	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	275						cilium	zinc ion binding			central_nervous_system(1)	1	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TTCACAGTAAGGAAATTTTCT	0.393													39	59					0	0	0.006230	0	0
MACC1	346389	broad.mit.edu	37	7	20198181	20198181	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:20198181G>A	uc003sus.3	-	5	2112	c.1803C>T	c.(1801-1803)GTC>GTT	p.V601V	MACC1_uc010kug.2_Silent_p.V601V	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	601	SH3.				positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TACCTCTGAGGACTCCTACAT	0.398													39	126					0	0	0.007835	0	0
ABCB5	340273	broad.mit.edu	37	7	20682906	20682906	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:20682906G>A	uc010kuh.2	+	6	651	c.414G>A	c.(412-414)AGG>AGA	p.R138R		NM_001163941	NP_001157413	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	322	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						AGACCAAGAGGATTCGAAAAC	0.428													13	25					0	0	0.001855	0	0
ABCB5	340273	broad.mit.edu	37	7	20784994	20784994	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:20784994C>T	uc003suw.3	+	17	2573	c.2027C>T	c.(2026-2028)CCA>CTA	p.P676L	ABCB5_uc010kuh.2_Missense_Mutation_p.P1121L	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	676	Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CGTGTGGTGCCATTAGATGAG	0.433													28	57					0	0	0.008361	0	0
DNAH11	8701	broad.mit.edu	37	7	21657364	21657364	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:21657364G>A	uc003svc.2	+	23	4269	c.4238G>A	c.(4237-4239)AGG>AAG	p.R1413K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1413	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTCAGGGACAGGCATTGGCAC	0.512									Kartagener_syndrome				15	31					0	0	0.003163	0	0
DNAH11	8701	broad.mit.edu	37	7	21737789	21737789	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:21737789C>T	uc003svc.2	+	37	6190	c.6159C>T	c.(6157-6159)TTC>TTT	p.F2053F		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2053	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CCCGAAAGTTCATTACGTTGT	0.433									Kartagener_syndrome				16	48					0	0	0.004990	0	0
DNAH11	8701	broad.mit.edu	37	7	21805179	21805179	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:21805179G>A	uc003svc.2	+	56	9126	c.9095G>A	c.(9094-9096)AGG>AAG	p.R3032K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3032	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTCAGCAGGAGGTTCATTGAG	0.413									Kartagener_syndrome				7	20					0	0	0.001984	0	0
OSBPL3	26031	broad.mit.edu	37	7	24902884	24902884	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:24902884C>T	uc003sxf.2	-	9	1210	c.805G>A	c.(805-807)GAA>AAA	p.E269K	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_Intron|OSBPL3_uc003sxg.2_Missense_Mutation_p.E269K|OSBPL3_uc003sxh.2_Intron|OSBPL3_uc003sxi.2_Intron|OSBPL3_uc003sxj.1_Missense_Mutation_p.E34K|OSBPL3_uc003sxk.1_Intron	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	269					lipid transport		lipid binding|protein binding			skin(1)	1						GATCTTTTTTCCTTTTTGGGA	0.448													16	19					0	0	0.006122	0	0
C7orf31	136895	broad.mit.edu	37	7	25182418	25182418	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:25182418C>G	uc003sxn.1	-	8	1261	c.700G>C	c.(700-702)GAG>CAG	p.E234Q	C7orf31_uc003sxm.1_Missense_Mutation_p.E76Q	NM_138811	NP_620166	Q8N865	CG031_HUMAN	hypothetical protein LOC136895	234											0						TTATTTTTCTCAACACCTCTG	0.383													30	29					0	0	0.001786	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378726	31378726	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:31378726C>T	uc003tch.2	-	2	510	c.157G>A	c.(157-159)GGA>AGA	p.G53R		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	53					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						gtttcttctccAGGGGCCCTT	0.308													26	55					0	0	0.003954	0	0
CCDC129	223075	broad.mit.edu	37	7	31682335	31682335	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:31682335G>A	uc003tcj.1	+	11	2344	c.1351G>A	c.(1351-1353)GGA>AGA	p.G451R	CCDC129_uc011kad.1_Missense_Mutation_p.G461R|CCDC129_uc003tci.1_Missense_Mutation_p.G302R|CCDC129_uc011kae.1_Missense_Mutation_p.G477R|CCDC129_uc003tck.1_Missense_Mutation_p.G359R	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	451											0						TGCTGAGAATGGAGGTAGAAA	0.512													17	18					0	0	0.004007	0	0
NPSR1	387129	broad.mit.edu	37	7	34851465	34851465	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:34851465C>T	uc003teg.1	+	4	596	c.468C>T	c.(466-468)TTC>TTT	p.F156F	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Silent_p.F156F|NPSR1_uc010kwt.1_Silent_p.F3F|NPSR1_uc010kwu.1_Intron|NPSR1_uc010kwv.1_Intron|NPSR1_uc003tei.1_Silent_p.F156F|NPSR1_uc010kww.1_Silent_p.F145F|NPSR1_uc011kar.1_Intron|AAA1_uc010kwy.2_Intron|AAA1_uc003tek.3_Intron	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	156	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	CCATGAAGTTCCTTCAAGGAG	0.443													38	34					0	0	0.006230	0	0
TBX20	57057	broad.mit.edu	37	7	35293225	35293225	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:35293225A>G	uc011kas.1	-	1	18	c.7T>C	c.(7-9)TTC>CTC	p.F3L		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	3						nucleus	DNA binding			central_nervous_system(1)	1						GACGCCGTGAACTCCATGGTC	0.642													15	13					0	0	0.001882	0	0
AOAH	313	broad.mit.edu	37	7	36616207	36616207	+	Silent	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:36616207T>G	uc003tfh.3	-	13	1395	c.994A>C	c.(994-996)AGG>CGG	p.R332R	AOAH_uc010kxf.2_Silent_p.R332R|AOAH_uc011kba.1_Silent_p.R300R	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	332					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						TGGTAGTCCCTGTGATTACAG	0.303													38	68					0	0	0.006999	0	0
H2AFV	94239	broad.mit.edu	37	7	44880610	44880610	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:44880610A>T	uc003tma.2	-	3	238	c.83T>A	c.(82-84)TTT>TAT	p.F28Y	H2AFV_uc003tlz.2_Missense_Mutation_p.F28Y|H2AFV_uc003tmb.2_Intron|H2AFV_uc003tmc.2_Missense_Mutation_p.F28Y|H2AFV_uc003tmd.2_Missense_Mutation_p.F2Y	NM_012412	NP_036544	Q71UI9	H2AV_HUMAN	H2A histone family, member V isoform 1	28					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCCCACAGGAAACTAAAAGAG	0.473													45	65					0	0	0.003610	0	0
PKD1L1	168507	broad.mit.edu	37	7	47894497	47894497	+	Silent	SNP	G	A	A	rs149586291		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:47894497G>A	uc003tny.1	-	30	4842	c.4842C>T	c.(4840-4842)CCC>CCT	p.P1614P		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1614	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GCAACATGACGGGAAATGCCC	0.383													35	41					0	0	0.006999	0	0
ABCA13	154664	broad.mit.edu	37	7	48317811	48317811	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:48317811G>A	uc003toq.2	+	18	7045	c.7020G>A	c.(7018-7020)ATG>ATA	p.M2340I		NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2340					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ATCACCTAATGAAAAGTTCAT	0.303													10	16					0	0	0.008291	0	0
ABCA13	154664	broad.mit.edu	37	7	48319316	48319316	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:48319316G>A	uc003toq.2	+	18	8550	c.8525G>A	c.(8524-8526)AGA>AAA	p.R2842K	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2842					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ACTTCCACAAGAACTTTGTTT	0.358													45	76					0	0	0.003610	0	0
COBL	23242	broad.mit.edu	37	7	51092834	51092834	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:51092834G>A	uc003tpr.3	-	12	3925	c.3740C>T	c.(3739-3741)TCC>TTC	p.S1247F	COBL_uc003tps.2_Missense_Mutation_p.S1257F|COBL_uc011kcl.1_Missense_Mutation_p.S1200F|COBL_uc003tpp.3_Missense_Mutation_p.S1033F|COBL_uc003tpq.3_Missense_Mutation_p.S1141F|COBL_uc003tpo.3_Missense_Mutation_p.S789F	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	1247	WH2 3.									skin(3)|ovary(2)	5	Glioma(55;0.08)					CCCTGTGCCGGAGCGGATGGC	0.627													30	78					0	0	0.001786	0	0
POM121L12	285877	broad.mit.edu	37	7	53103702	53103702	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:53103702C>T	uc003tpz.2	+	1	354	c.338C>T	c.(337-339)TCC>TTC	p.S113F		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	113											0						CGAGACCTCTCCTGTGCCTGG	0.721													6	23					0	0	0.003080	0	0
EGFR	1956	broad.mit.edu	37	7	55229314	55229314	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:55229314C>T	uc003tqk.2	+	13	1867	c.1621C>T	c.(1621-1623)CTT>TTT	p.L541F	EGFR_uc003tqi.2_Missense_Mutation_p.L541F|EGFR_uc003tqj.2_Missense_Mutation_p.L541F|EGFR_uc010kzg.1_Missense_Mutation_p.L496F|EGFR_uc011kco.1_Missense_Mutation_p.L488F|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_Intron	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	541	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAAGTGCAACCTTCTGGAGGG	0.532		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			42	118					0	0	0.003610	0	0
LOC643955	643955	broad.mit.edu	37	7	62758735	62758735	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:62758735G>A	uc011kdj.1	-	2	143	c.75C>T	c.(73-75)TTC>TTT	p.F25F		NR_003952				Homo sapiens cDNA clone IMAGE:30377995, containing frame-shift errors.												0						CCTCCAGAGAGAATTCTATAG	0.433													7	76					0	0	0.001984	0	0
ZNF679	168417	broad.mit.edu	37	7	63720636	63720636	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:63720636C>T	uc003tsx.2	+	3	346	c.77C>T	c.(76-78)TCT>TTT	p.S26F		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	26	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATAGAATTCTCTCTGGAGGAG	0.418													12	29					0	0	0.000978	0	0
CCDC146	57639	broad.mit.edu	37	7	76871183	76871183	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:76871183G>A	uc003uga.2	+	4	542	c.415G>A	c.(415-417)GAA>AAA	p.E139K		NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	139	Potential.									ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				TGCAGTGAAGGAAAGAGAGTT	0.373													21	26					0	0	0.001882	0	0
CACNA2D1	781	broad.mit.edu	37	7	81598265	81598265	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:81598265G>A	uc003uhr.1	-	29	2589	c.2333C>T	c.(2332-2334)TCG>TTG	p.S778L	CACNA2D1_uc011kgy.1_Intron	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	790	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CATAATGCCCGATTCATAGGC	0.279													43	53					0	0	0.003610	0	0
PCLO	27445	broad.mit.edu	37	7	82453677	82453677	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:82453677G>A	uc003uhx.2	-	19	14760	c.14471C>T	c.(14470-14472)CCT>CTT	p.P4824L	PCLO_uc003uhv.2_Missense_Mutation_p.P4824L|PCLO_uc003uht.1_Missense_Mutation_p.P266L|PCLO_uc003uhu.1_Missense_Mutation_p.P245L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4686					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTCTTTGAGAGGATACCACCT	0.398													20	34					0	0	0.001882	0	0
PCLO	27445	broad.mit.edu	37	7	82544134	82544134	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:82544134C>T	uc003uhx.2	-	7	13457	c.13168G>A	c.(13168-13170)GAT>AAT	p.D4390N	PCLO_uc003uhv.2_Missense_Mutation_p.D4390N|PCLO_uc010lec.2_Missense_Mutation_p.D1355N	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4321					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CCAAACTGATCCCTGGTGTCT	0.522													18	18					0	0	0.006122	0	0
PCLO	27445	broad.mit.edu	37	7	82584366	82584366	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:82584366G>A	uc003uhx.2	-	5	6192	c.5903C>T	c.(5902-5904)TCG>TTG	p.S1968L	PCLO_uc003uhv.2_Missense_Mutation_p.S1968L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1899					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCCATCTACCGATCCATTGTA	0.363													47	64					0	0	0.003610	0	0
PCLO	27445	broad.mit.edu	37	7	82763746	82763746	+	Silent	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:82763746A>T	uc003uhx.2	-	3	3409	c.3120T>A	c.(3118-3120)CCT>CCA	p.P1040P	PCLO_uc003uhv.2_Silent_p.P1040P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	986					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CAGCCTTTTGAGGCTCAGCTG	0.423													12	16					0	0	0.001855	0	0
SEMA3D	223117	broad.mit.edu	37	7	84666346	84666346	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:84666346G>A	uc003uic.2	-	10	1090	c.1050C>T	c.(1048-1050)TCC>TCT	p.S350S	SEMA3D_uc010led.2_Silent_p.S350S|SEMA3D_uc003uib.2_5'UTR	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	350	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CTTTGAAGATGGAGCTGGAAA	0.299													14	14					0	0	0.001855	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86522401	86522401	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:86522401A>C	uc011kha.1	-	20	2886	c.2701T>G	c.(2701-2703)TGG>GGG	p.W901G	KIAA1324L_uc003uif.1_Missense_Mutation_p.W661G|KIAA1324L_uc011kgz.1_Missense_Mutation_p.W787G|KIAA1324L_uc003uie.2_Missense_Mutation_p.W734G	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	901	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					GGTTCATTCCACACATACAAG	0.368													28	57					0	0	0.007291	0	0
ABCB4	5244	broad.mit.edu	37	7	87042978	87042978	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:87042978C>T	uc003uiv.1	-	22	2814	c.2738G>A	c.(2737-2739)AGA>AAA	p.R913K	ABCB4_uc003uiw.1_Missense_Mutation_p.R913K|ABCB4_uc003uix.1_Missense_Mutation_p.R913K	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	913	Cytoplasmic (By similarity).|ABC transmembrane type-1 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTCAAATTTTCTTTCCTGGGT	0.358													31	47					0	0	0.002836	0	0
PEX1	5189	broad.mit.edu	37	7	92138668	92138668	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:92138668G>A	uc003uly.2	-	9	1741	c.1645C>T	c.(1645-1647)CCT>TCT	p.P549S	PEX1_uc011khr.1_Missense_Mutation_p.P341S|PEX1_uc010ley.2_Missense_Mutation_p.P549S|PEX1_uc011khs.1_Missense_Mutation_p.P227S|PEX1_uc011kht.1_Intron	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	549					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TTTAAAAAAGGAAGAATAAAG	0.333													14	20					0	0	0.001855	0	0
COL1A2	1278	broad.mit.edu	37	7	94051224	94051224	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:94051224T>G	uc003ung.1	+	39	2834	c.2363T>G	c.(2362-2364)TTC>TGC	p.F788C	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	788			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	ATGACTGGTTTCCCTGGTGCT	0.448										HNSCC(75;0.22)			11	28					0	0	0.001368	0	0
CASD1	64921	broad.mit.edu	37	7	94163044	94163044	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:94163044G>A	uc003uni.3	+	7	785	c.558G>A	c.(556-558)ATG>ATA	p.M186I	CASD1_uc003unh.2_Missense_Mutation_p.M186I|CASD1_uc003unj.3_Missense_Mutation_p.M186I	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	186						integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AATATAAAATGAACATCACCT	0.328													19	37					0	0	0.007413	0	0
CYP3A5	1577	broad.mit.edu	37	7	99247856	99247856	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:99247856C>T	uc003urq.2	-	12	1341	c.1254_splice	c.e12-1	p.R418_splice	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_Splice_Site_p.R238_splice|CYP3A5_uc003urr.2_Splice_Site_p.R305_splice|CYP3A5_uc011kiy.1_Splice_Site_p.R408_splice|CYP3A5_uc003urs.2_Splice_Site_p.R66_splice|CYP3A5_uc010lgg.2_Splice_Site_p.L24_splice	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,						alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	CTTACTGAACCTAGTTCCATA	0.408													32	54					0	0	0.002836	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99627572	99627572	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:99627572C>T	uc003usk.1	+	4	888	c.669C>T	c.(667-669)TCC>TCT	p.S223S	ZKSCAN1_uc003usl.1_Silent_p.S187S|ZKSCAN1_uc003usm.1_Silent_p.S10S	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	223					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			CAGCGGATTCCCAGGTGAGCT	0.597													13	20					0	0	0.001855	0	0
ZAN	7455	broad.mit.edu	37	7	100348286	100348286	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:100348286C>T	uc003uwj.2	+	12	1453	c.1288C>T	c.(1288-1290)CAG>TAG	p.Q430*	ZAN_uc003uwk.2_Nonsense_Mutation_p.Q430*|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	430	MAM 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CGAGTTCTCCCAGGCAGGCCA	0.577													6	14					0	0	0.001168	0	0
ZAN	7455	broad.mit.edu	37	7	100382454	100382454	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:100382454C>T	uc003uwj.2	+	37	6997	c.6832C>T	c.(6832-6834)CCT>TCT	p.P2278S	ZAN_uc003uwk.2_Missense_Mutation_p.P2278S|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Missense_Mutation_p.P328S	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2278	VWFC 4.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGGCTCCATCCCTGTGAGTGG	0.562													8	9					0	0	0.003080	0	0
MUC17	140453	broad.mit.edu	37	7	100679002	100679002	+	Silent	SNP	A	G	G	rs142375735		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:100679002A>G	uc003uxp.1	+	3	4358	c.4305A>G	c.(4303-4305)TCA>TCG	p.S1435S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1435	Extracellular (Potential).|Ser-rich.|22.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AAGCCACTTCATCTCCTACAA	0.522													72	117					0	0	0.003610	0	0
MUC17	140453	broad.mit.edu	37	7	100686884	100686884	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:100686884C>T	uc003uxp.1	+	3	12240	c.12187C>T	c.(12187-12189)CCA>TCA	p.P4063S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4063	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCACACCATCCCACCTACATT	0.547													34	44					0	0	0.003755	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839346	100839346	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:100839346G>A	uc003uyc.2	-	7	1074	c.907C>T	c.(907-909)CCC>TCC	p.P303S	MOGAT3_uc010lhr.2_Missense_Mutation_p.P235L	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	303					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					TCCTCGGTGGGGTGGAGGCGC	0.667													7	5					0	0	0.001984	0	0
RELN	5649	broad.mit.edu	37	7	103185575	103185575	+	Silent	SNP	G	A	A	rs146913017	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:103185575G>A	uc003vca.2	-	42	6679	c.6519C>T	c.(6517-6519)TTC>TTT	p.F2173F	RELN_uc010liz.2_Silent_p.F2173F	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2173					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GACTACCTTCGAAATCATCTT	0.323													15	18					0	0	0.002450	0	0
RELN	5649	broad.mit.edu	37	7	103216024	103216024	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:103216024C>T	uc003vca.2	-	29	4434	c.4274G>A	c.(4273-4275)GGA>GAA	p.G1425E	RELN_uc010liz.2_Missense_Mutation_p.G1425E	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1425	EGF-like 3.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GAAACACACTCCTGAAATGCA	0.438													18	30					0	0	0.001523	0	0
RELN	5649	broad.mit.edu	37	7	103236980	103236980	+	Silent	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:103236980G>C	uc003vca.2	-	25	3622	c.3462C>G	c.(3460-3462)CTC>CTG	p.L1154L	RELN_uc010liz.2_Silent_p.L1154L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1154					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGTACTGAAGGAGGACGCCCT	0.522													56	63					0	0	0.003610	0	0
MLL5	55904	broad.mit.edu	37	7	104752452	104752452	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:104752452C>T	uc003vcm.2	+	27	4783	c.4249C>T	c.(4249-4251)CCT>TCT	p.P1417S	MLL5_uc010ljc.2_Missense_Mutation_p.P1417S|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.P151S	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1417					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						GAATCATCCTCCTCAGACACA	0.423													27	25					0	0	0.005443	0	0
GPR85	54329	broad.mit.edu	37	7	112724432	112724432	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:112724432G>C	uc010ljv.2	-	2	862	c.345C>G	c.(343-345)ATC>ATG	p.I115M	GPR85_uc003vgp.1_Missense_Mutation_p.I115M|GPR85_uc003vgq.2_Missense_Mutation_p.I115M|GPR85_uc010ljw.1_Missense_Mutation_p.I115M	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	115	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						TGGTGACACTGATGCAGAAGA	0.468													11	21					0	0	0.008291	0	0
CFTR	1080	broad.mit.edu	37	7	117182159	117182160	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:117182159_117182160GG>AA	uc003vjd.2	+	9	1338_1339	c.1206_1207GG>AA	c.(1204-1209)GAGGAG>GAAAAG	p.E403K	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	403	Cytoplasmic (Potential).				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CCTTCTGGGAGGAGGTCAGAAT	0.312									Cystic_Fibrosis				12	18					0	0	0.004672	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121651385	121651385	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:121651385C>T	uc003vjy.2	+	12	2680	c.2285C>T	c.(2284-2286)TCC>TTC	p.S762F	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	762	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CTTCAACCTTCCTACAGTAGT	0.493													55	57					0	0	0.003610	0	0
CADPS2	93664	broad.mit.edu	37	7	122019443	122019443	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:122019443G>A	uc010lkp.2	-	24	3529	c.3366C>T	c.(3364-3366)ATC>ATT	p.I1122I	CADPS2_uc011knx.1_Silent_p.I497I|CADPS2_uc003vkg.3_Silent_p.I776I|CADPS2_uc010lkq.2_Silent_p.I1081I	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	1122					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						ACAGTGAAATGATTTCTTTTA	0.259													7	19					0	0	0.004482	0	0
SLC13A1	6561	broad.mit.edu	37	7	122821088	122821088	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:122821088G>A	uc003vkm.2	-	2	192	c.167C>T	c.(166-168)TCG>TTG	p.S56L	SLC13A1_uc010lks.2_5'UTR	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	56	Helical; (Potential).					integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	AGCTGTTACCGACAGAGGCAA	0.428													16	30					0	0	0.003163	0	0
SPAM1	6677	broad.mit.edu	37	7	123594331	123594331	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:123594331G>A	uc003vld.2	+	4	1109	c.707G>A	c.(706-708)GGA>GAA	p.G236E	SPAM1_uc003vle.2_Missense_Mutation_p.G236E|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.G236E|SPAM1_uc010lku.2_Missense_Mutation_p.G236E	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	236					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	GGTTACAATGGAAGTTGCTTC	0.368													24	35					0	0	0.002780	0	0
Unknown	0	broad.mit.edu	37	7	124116487	124116487	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:124116487G>A	uc011kod.1	+	1	63	c.63G>A	c.(61-63)GAG>GAA	p.E21E		NM_001085395	NP_001078864			RecName: Full=Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 2;          Short=CTD phosphatase SSU72-like protein 2;          EC=3.1.3.16;																		GGAGCATGGAGGCCCACAGCA	0.542													13	18					0	0	0.002450	0	0
WDR91	29062	broad.mit.edu	37	7	134889048	134889048	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:134889048G>A	uc003vsp.2	-	6	925	c.863C>T	c.(862-864)TCG>TTG	p.S288L	WDR91_uc010lmq.2_5'UTR|WDR91_uc010lmr.2_RNA	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	288										breast(2)|ovary(1)|skin(1)	4						TTTCTTGGCCGAGCTCTGAGG	0.592													15	27					0	0	0.006122	0	0
FAM180A	389558	broad.mit.edu	37	7	135418972	135418972	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:135418972G>A	uc003vtd.2	-	3	539	c.273C>T	c.(271-273)ACC>ACT	p.T91T	FAM180A_uc010lmt.2_RNA|FAM180A_uc010lmu.2_Silent_p.T91T	NM_205855	NP_995327	Q6UWF9	F180A_HUMAN	hypothetical protein LOC389558 precursor	91						extracellular region				ovary(2)	2						TGTTGCAGACGGTGCGGAAGT	0.587													33	70					0	0	0.003755	0	0
KIAA1549	57670	broad.mit.edu	37	7	138602377	138602377	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:138602377G>A	uc011kql.1	-	2	2044	c.1995C>T	c.(1993-1995)CCC>CCT	p.P665P	KIAA1549_uc003vuk.3_Silent_p.P615P|KIAA1549_uc011kqj.1_Silent_p.P665P	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	665	Ser-rich.					integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TCTCAACCAAGGGAGAAAAAG	0.498			O	BRAF	pilocytic astrocytoma								8	12					0	0	0.003080	0	0
NDUFB2	4708	broad.mit.edu	37	7	140404669	140404669	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:140404669C>T	uc003vwa.2	+	3	317	c.253C>T	c.(253-255)CCG>TCG	p.P85S	NDUFB2_uc010lnl.2_RNA	NM_004546	NP_004537	O95178	NDUB2_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	85					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.00956)				NADH(DB00157)	GGGTCACTTTCCGTATCCTGA	0.378													29	35					0	0	0.001786	0	0
TRPV5	56302	broad.mit.edu	37	7	142606723	142606723	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:142606723G>A	uc003wby.1	-	14	2092	c.1828C>T	c.(1828-1830)CGC>TGC	p.R610C		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	610	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CACAGGCAGCGAGGCAGCTTC	0.597													11	12					0	0	0.001368	0	0
OR6B1	135946	broad.mit.edu	37	7	143701692	143701692	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:143701692C>T	uc003wdt.1	+	1	603	c.603C>T	c.(601-603)ATC>ATT	p.I201I		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					TAGACTTTATCCTGGCACTGG	0.458													37	45					0	0	0.006999	0	0
OR2A5	393046	broad.mit.edu	37	7	143748115	143748115	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:143748115G>A	uc011ktw.1	+	1	621	c.621G>A	c.(619-621)CTG>CTA	p.L207L		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TGTTCATCCTGGTGGGGCCGC	0.582													40	47					0	0	0.007835	0	0
OR2A5	393046	broad.mit.edu	37	7	143748222	143748222	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:143748222C>T	uc011ktw.1	+	1	728	c.728C>T	c.(727-729)TCC>TTC	p.S243F		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					ACCTGCTCCTCCCACCTTTGC	0.622													32	46					0	0	0.008361	0	0
OR2A2	442361	broad.mit.edu	37	7	143807593	143807593	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:143807593G>A	uc011ktz.1	+	1	918	c.918G>A	c.(916-918)AGG>AGA	p.R306R		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					CACTCCAGAGGAAGAGGTCCA	0.433													34	37					0	0	0.002836	0	0
PDIA4	9601	broad.mit.edu	37	7	148701261	148701261	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:148701261C>T	uc003wff.2	-	10	1845	c.1563G>A	c.(1561-1563)AAG>AAA	p.K521K		NM_004911	NP_004902	P13667	PDIA4_HUMAN	protein disulfide isomerase A4 precursor	521	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			lung(5)|ovary(1)	6	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			CCTTGTTGTTCTTGGGCACTG	0.557													43	79					0	0	0.003610	0	0
SSPO	23145	broad.mit.edu	37	7	149490420	149490420	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:149490420G>A	uc010lpk.2	+	40	5896	c.5896G>A	c.(5896-5898)GGG>AGG	p.G1966R		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1966	VWFC 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCCTGTGAGGGGTGTGAGCA	0.552													8	22					0	0	0.008291	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325516	150325516	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:150325516C>T	uc003whn.2	-	3	594	c.170G>A	c.(169-171)GGA>GAA	p.G57E	GIMAP6_uc003whm.2_Intron	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	57							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GATGCTGTTTCCTGTTGCACT	0.542													96	126					0	0	0.003610	0	0
ABP1	26	broad.mit.edu	37	7	150554425	150554425	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:150554425G>A	uc003why.1	+	3	5085	c.867G>A	c.(865-867)GGG>GGA	p.G289G	ABP1_uc003whz.1_Silent_p.G289G|ABP1_uc003wia.1_Silent_p.G289G	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	289					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	AGCCCCGCGGGGACTTCCCCA	0.701													4	4					0	0	0.000248	0	0
KCNH2	3757	broad.mit.edu	37	7	150648756	150648756	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:150648756C>T	uc003wic.2	-	7	1738	c.1725G>A	c.(1723-1725)GAG>GAA	p.E575E	KCNH2_uc003wib.2_Silent_p.E235E|KCNH2_uc011kux.1_Silent_p.E479E|KCNH2_uc003wid.2_Silent_p.E235E|KCNH2_uc003wie.2_Silent_p.E575E	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	575	Extracellular (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TGTGTGGCTGCTCCATGTTGC	0.622													21	17					0	0	0.002299	0	0
PAXIP1	22976	broad.mit.edu	37	7	154747269	154747269	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:154747269G>A	uc003wlp.2	-	15	2665	c.2622C>T	c.(2620-2622)TTC>TTT	p.F874F	PAXIP1_uc003wlq.1_Silent_p.F840F|PAXIP1_uc011kvs.1_Silent_p.F838F	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	874	BRCT 5.|Interaction with TP53BP1.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		GGACAGGCTCGAATCCAGTGA	0.363													11	27					0	0	0.001855	0	0
VIPR2	7434	broad.mit.edu	37	7	158827272	158827272	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:158827272G>A	uc003woh.2	-	9	1065	c.879C>T	c.(877-879)ATC>ATT	p.I293I	VIPR2_uc010lqx.2_RNA|VIPR2_uc010lqy.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	293	Helical; Name=5; (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		GACTACTTACGATGATGGAAA	0.458													27	35					0	0	0.001786	0	0
MIR596	693181	broad.mit.edu	37	8	1765429	1765429	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:1765429C>T	hsa-mir-596|MI0003608	+			c.33C>T																				0						CCCGGCTCCTCGGGAACCTGC	0.448													9	23					0	0	0.006214	0	0
CSMD1	64478	broad.mit.edu	37	8	3087615	3087615	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:3087615C>G	uc011kwk.1	-	27	4685	c.4295G>C	c.(4294-4296)TGT>TCT	p.C1432S	CSMD1_uc011kwj.1_Missense_Mutation_p.C824S|CSMD1_uc003wqe.2_Missense_Mutation_p.C588S	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1432	Extracellular (Potential).|Sushi 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAGCTGCACACAGGTGATTTT	0.478													16	61					0	0	0.001523	0	0
RP1L1	94137	broad.mit.edu	37	8	10465835	10465835	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:10465835G>A	uc003wtc.2	-	4	6002	c.5773C>T	c.(5773-5775)CTG>TTG	p.L1925L		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1925					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCAGTCTCCAGGGCCTCTACA	0.627													36	95					0	0	0.003755	0	0
DEFB136	613210	broad.mit.edu	37	8	11831451	11831451	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:11831451G>A	uc011kxm.1	-	2	232	c.232C>T	c.(232-234)CAT>TAT	p.H78Y		NM_001033018	NP_001028190	Q30KP8	DB136_HUMAN	beta-defensin 136 precursor	78					defense response to bacterium	extracellular region					0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.163)		TCCTTTTAATGAACCCATGGA	0.453													49	165					0	0	0.003610	0	0
EPB49	2039	broad.mit.edu	37	8	21938632	21938632	+	Silent	SNP	C	T	T	rs146626785		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:21938632C>T	uc011kyt.1	+	14	1261	c.1032C>T	c.(1030-1032)CCC>CCT	p.P344P	EPB49_uc010ltl.2_Silent_p.P322P|EPB49_uc010ltn.2_Silent_p.P297P|EPB49_uc011kyu.1_Silent_p.P344P|EPB49_uc011kyv.1_Silent_p.P344P|EPB49_uc010ltq.2_Silent_p.P322P	NM_001114136	NP_001107608	Q08495	DEMA_HUMAN	erythrocyte membrane protein band 4.9 isoform 1	344	HP.				actin filament bundle assembly|actin filament capping	actin cytoskeleton|nucleus	actin binding			central_nervous_system(1)	1				Colorectal(74;9.05e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0631)		AGATCTATCCCTATGAAATGC	0.587													14	39					0	0	0.001855	0	0
SLC39A14	23516	broad.mit.edu	37	8	22275267	22275267	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:22275267C>T	uc003xbq.3	+	8	1426	c.1251C>T	c.(1249-1251)ATC>ATT	p.I417I	SLC39A14_uc011kzg.1_Silent_p.I417I|SLC39A14_uc003xbp.3_Silent_p.I417I|SLC39A14_uc011kzh.1_Silent_p.I417I	NM_001128431	NP_001121903	Q15043	S39AE_HUMAN	solute carrier family 39 (zinc transporter),	417	Helical; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity				0				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)		CCTTTGGCATCCTGGCCGGCA	0.502													24	65					0	0	0.002780	0	0
PPP3CC	5533	broad.mit.edu	37	8	22370923	22370923	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:22370923C>T	uc003xbs.2	+	6	1075	c.748C>T	c.(748-750)CGA>TGA	p.R250*	PPP3CC_uc003xbr.1_Nonsense_Mutation_p.R250*|PPP3CC_uc011kzi.1_Nonsense_Mutation_p.R250*|PPP3CC_uc003xbt.2_Nonsense_Mutation_p.R250*	NM_005605	NP_005596	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma	250					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		CAACACTGTCCGAGGGTGCTC	0.428													45	78					0	0	0.003610	0	0
CLU	1191	broad.mit.edu	37	8	27455997	27455997	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:27455997C>T	uc003xfw.1	-	7	1378	c.1320G>A	c.(1318-1320)CAG>CAA	p.Q440Q	CLU_uc010lux.1_Silent_p.Q305Q|CLU_uc003xfx.1_Silent_p.Q440Q|CLU_uc003xfy.1_Silent_p.Q451Q|CLU_uc003xfz.1_Silent_p.Q492Q	NM_203339	NP_976084	P10909	CLUS_HUMAN	clusterin isoform 2	440					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			ovary(2)	2		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		TGCGGTATTCCTGCAGCGCTT	0.537													37	73					0	0	0.004878	0	0
CLU	1191	broad.mit.edu	37	8	27462528	27462528	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:27462528G>A	uc003xfw.1	-	4	800	c.742C>T	c.(742-744)CTT>TTT	p.L248F	CLU_uc010lux.1_Missense_Mutation_p.L113F|CLU_uc003xfx.1_Missense_Mutation_p.L248F|CLU_uc003xfy.1_Missense_Mutation_p.L259F|CLU_uc003xfz.1_Missense_Mutation_p.L300F	NM_203339	NP_976084	P10909	CLUS_HUMAN	clusterin isoform 2	248					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			ovary(2)	2		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		ATCATCTCAAGGAAGGGCTGG	0.577													32	62					0	0	0.002836	0	0
NRG1	3084	broad.mit.edu	37	8	32453407	32453407	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:32453407C>T	uc003xiv.2	+	2	679	c.162C>T	c.(160-162)GTC>GTT	p.V54V	NRG1_uc003xip.2_Silent_p.V269V|NRG1_uc003xir.2_Silent_p.V54V|NRG1_uc010lvl.2_Silent_p.V54V|NRG1_uc010lvm.2_Silent_p.V54V|NRG1_uc010lvn.2_Silent_p.V54V|NRG1_uc003xis.2_Silent_p.V54V|NRG1_uc011lbf.1_Silent_p.V54V|NRG1_uc010lvo.2_Silent_p.V54V|NRG1_uc003xiu.2_Silent_p.V54V|NRG1_uc003xiw.2_Silent_p.V54V|NRG1_uc003xit.2_Silent_p.V54V|NRG1_uc010lvr.2_5'UTR|NRG1_uc010lvs.2_5'UTR|NRG1_uc010lvp.2_Silent_p.V20V|NRG1_uc010lvq.2_Silent_p.V20V	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	54	Extracellular (Potential).|Ig-like C2-type.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CCAAACTAGTCCTTCGGTGTG	0.403													29	101					0	0	0.002445	0	0
RNF122	79845	broad.mit.edu	37	8	33406360	33406360	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:33406360G>A	uc003xjo.1	-	6	781	c.379C>T	c.(379-381)CGC>TGC	p.R127C		NM_024787	NP_079063	Q9H9V4	RN122_HUMAN	ring finger protein 122	127	RING-type; atypical.					endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		CAGACACAGCGAACTTCCAGC	0.498													60	120					0	0	0.003610	0	0
DUSP26	78986	broad.mit.edu	37	8	33454829	33454829	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:33454829G>A	uc003xjp.2	-	2	538	c.205C>T	c.(205-207)CTC>TTC	p.L69F	DUSP26_uc003xjq.2_Missense_Mutation_p.L69F	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	69	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		CCGAGATAGAGGCCTGGCCAG	0.552													9	9					0	0	0.006214	0	0
HTRA4	203100	broad.mit.edu	37	8	38832575	38832575	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:38832575G>A	uc003xmj.2	+	2	607	c.492G>A	c.(490-492)AGG>AGA	p.R164R		NM_153692	NP_710159	P83105	HTRA4_HUMAN	HtrA serine peptidase 4 precursor	164					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			GCCCGCTCAGGAGGAATTACA	0.547													49	166					0	0	0.003610	0	0
ANK1	286	broad.mit.edu	37	8	41577322	41577322	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:41577322G>A	uc003xok.2	-	10	1048	c.964C>T	c.(964-966)CGG>TGG	p.R322W	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.R322W|ANK1_uc003xoj.2_Missense_Mutation_p.R322W|ANK1_uc003xol.2_Missense_Mutation_p.R322W|ANK1_uc003xom.2_Missense_Mutation_p.R355W	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	322	ANK 9.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			AACAGGAGCCGGACACAGTCG	0.572													37	97					0	0	0.006230	0	0
CHRNB3	1142	broad.mit.edu	37	8	42586909	42586909	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:42586909C>A	uc003xpi.1	+	5	587	c.459C>A	c.(457-459)TGC>TGA	p.C153*		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	153	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AAAGCTCCTGCACCATGGACG	0.527													15	24					1.49906e-05	2.27434e-05	0.002450	1	0
PXDNL	137902	broad.mit.edu	37	8	52320734	52320734	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:52320734G>A	uc003xqu.3	-	17	3551	c.3450C>T	c.(3448-3450)ATC>ATT	p.I1150I	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1150					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CATATGGTGGGATCCCGTGGT	0.448													44	157					0	0	0.003610	0	0
OPRK1	4986	broad.mit.edu	37	8	54142080	54142080	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:54142080G>A	uc003xrh.1	-	3	1295	c.920C>T	c.(919-921)GCT>GTT	p.A307V	OPRK1_uc003xri.1_Missense_Mutation_p.A307V|OPRK1_uc010lyc.1_Missense_Mutation_p.A218V	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	307	Extracellular (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	GGAGAGAGCAGCTGTGCTGTG	0.527													28	42					0	0	0.006320	0	0
RGS20	8601	broad.mit.edu	37	8	54852200	54852200	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:54852200G>A	uc003xrp.2	+	3	667	c.575G>A	c.(574-576)GGC>GAC	p.G192D	RGS20_uc003xrq.2_Missense_Mutation_p.G77D|RGS20_uc010lye.2_Intron|RGS20_uc010lyf.2_Intron|RGS20_uc003xrs.2_Missense_Mutation_p.G45D|RGS20_uc003xrt.2_Intron	NM_170587	NP_733466	O76081	RGS20_HUMAN	regulator of G-protein signaling 20 isoform a	192					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			GACACACCAGGCGCCGCCCCA	0.572													9	26					0	0	0.008291	0	0
RP1	6101	broad.mit.edu	37	8	55541479	55541479	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:55541479A>G	uc003xsd.1	+	4	5185	c.5037A>G	c.(5035-5037)TCA>TCG	p.S1679S	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1679					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGGGCAGTCATTTGGCTCTT	0.413													90	117					0	0	0.003610	0	0
TMEM68	137695	broad.mit.edu	37	8	56663611	56663611	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:56663611A>T	uc003xsg.1	-	3	668	c.599T>A	c.(598-600)GTT>GAT	p.V200D	TMEM68_uc003xsh.1_Missense_Mutation_p.V200D	NM_152417	NP_689630	Q96MH6	TMM68_HUMAN	transmembrane protein 68	200						integral to membrane	acyltransferase activity			skin(1)	1			Epithelial(17;0.000361)|all cancers(17;0.00326)			GGCTTCTCGAACTCCACCTGG	0.413													18	93					0	0	0.007413	0	0
TGS1	96764	broad.mit.edu	37	8	56699515	56699515	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:56699515G>A	uc003xsj.3	+	4	1445	c.1058G>A	c.(1057-1059)AGC>AAC	p.S353N	TGS1_uc010lyh.2_Missense_Mutation_p.S257N	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	353					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			GAAGTTAGTAGCAAAAGAGAG	0.438													22	83					0	0	0.001882	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409365	59409365	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:59409365C>T	uc003xtm.3	-	3	769	c.706G>A	c.(706-708)GAG>AAG	p.E236K		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	236					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GCCAGTTTCTCCCGGGCATTG	0.498									Neonatal_Giant_Cell_Hepatitis				42	224					0	0	0.008740	0	0
TOX	9760	broad.mit.edu	37	8	59720342	59720342	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:59720342C>T	uc003xtw.1	-	9	1766	c.1545G>A	c.(1543-1545)GGG>GGA	p.G515G		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	515						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				TCTGCATGCCCCTGTAGGAAG	0.448											OREG0018787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	82					0	0	0.003163	0	0
TOX	9760	broad.mit.edu	37	8	59720828	59720828	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:59720828C>T	uc003xtw.1	-	8	1614	c.1393G>A	c.(1393-1395)GGA>AGA	p.G465R		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	465						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				AGAGTAAATCCCTGAAAGGGA	0.418											OREG0018787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	74					0	0	0.007413	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66963868	66963868	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:66963868G>A	uc003xvs.1	+	3	377	c.86G>A	c.(85-87)GGA>GAA	p.G29E	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	29	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			CTGCATAAGGGAGCATCAAAT	0.408													20	130					0	0	0.001523	0	0
TRIM55	84675	broad.mit.edu	37	8	67040674	67040674	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:67040674G>A	uc003xvv.2	+	2	530	c.304G>A	c.(304-306)GAA>AAA	p.E102K	TRIM55_uc003xvu.2_Missense_Mutation_p.E102K|TRIM55_uc003xvw.2_Missense_Mutation_p.E102K|TRIM55_uc003xvx.2_Missense_Mutation_p.E102K	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	102				E -> G (in Ref. 2; CAC43019/CAC43020).		cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CCTGCTGGTGGAAAATATCAT	0.468													22	205					0	0	0.007291	0	0
TRIM55	84675	broad.mit.edu	37	8	67086797	67086797	+	Missense_Mutation	SNP	C	T	T	rs149867342		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:67086797C>T	uc003xvv.2	+	10	1842	c.1616C>T	c.(1615-1617)TCC>TTC	p.S539F	TRIM55_uc003xvu.2_3'UTR|TRIM55_uc003xvw.2_Missense_Mutation_p.S443F|TRIM55_uc003xvx.2_Missense_Mutation_p.S232F	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	539						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding	p.S539F(1)		skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CATATCTTCTCCTTTTCCTGG	0.547													32	229					0	0	0.002836	0	0
VCPIP1	80124	broad.mit.edu	37	8	67547158	67547158	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:67547158G>A	uc003xwn.2	-	3	3506	c.3247C>T	c.(3247-3249)CGA>TGA	p.R1083*		NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	1083					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			GGAGCTATTCGAATAAGCTCA	0.403													20	100					0	0	0.007413	0	0
PRDM14	63978	broad.mit.edu	37	8	70971050	70971050	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:70971050C>T	uc003xym.2	-	6	1413	c.1211G>A	c.(1210-1212)AGA>AAA	p.R404K		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	404	C2H2-type 1; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CTTCCCACATCTTTCACATCT	0.428													19	79					0	0	0.002299	0	0
PRDM14	63978	broad.mit.edu	37	8	70980503	70980503	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:70980503C>T	uc003xym.2	-	4	1076	c.874G>A	c.(874-876)GAA>AAA	p.E292K		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	292	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GTCTTCACTTCACTGGCATTG	0.493													19	120					0	0	0.008871	0	0
TRPA1	8989	broad.mit.edu	37	8	72966005	72966005	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:72966005G>A	uc003xza.2	-	13	1802	c.1627C>T	c.(1627-1629)CGC>TGC	p.R543C		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	543	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TCATCCAGGCGATCTGTGCAC	0.478													7	47					0	0	0.004482	0	0
C8orf84	157869	broad.mit.edu	37	8	73993429	73993430	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:73993429_73993430CC>TT	uc003xzf.2	-	2	438_439	c.233_234GG>AA	c.(232-234)GGG>GAA	p.G78E		NM_153225	NP_694957	Q8IVN8	RPESP_HUMAN	RPE-spondin precursor	78	TSP type-1.				immune response	extracellular region	polysaccharide binding|scavenger receptor activity				0						GGCTCCATTCCCCCACGAAGCA	0.629													9	65					0	0	0.004672	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617776	77617776	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:77617776G>A	uc003yav.2	+	2	1840	c.1453G>A	c.(1453-1455)GAG>AAG	p.E485K	ZFHX4_uc003yat.1_Missense_Mutation_p.E485K|ZFHX4_uc003yau.1_Missense_Mutation_p.E485K|ZFHX4_uc003yaw.1_Missense_Mutation_p.E485K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	485						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTTGATGACGAGGAAGTATT	0.423										HNSCC(33;0.089)			9	33					0	0	0.004482	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764947	77764947	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:77764947G>A	uc003yav.2	+	10	6042	c.5655G>A	c.(5653-5655)AAG>AAA	p.K1885K	ZFHX4_uc003yau.1_Silent_p.K1930K|ZFHX4_uc003yaw.1_Silent_p.K1885K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1885						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACAGGCAGAAGGTACAGAAGA	0.413										HNSCC(33;0.089)			17	78					0	0	0.007413	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765793	77765793	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:77765793C>T	uc003yav.2	+	10	6888	c.6501C>T	c.(6499-6501)CCC>CCT	p.P2167P	ZFHX4_uc003yau.1_Silent_p.P2212P|ZFHX4_uc003yaw.1_Silent_p.P2167P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2167						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATCCACAGCCCACCTCTTTAG	0.373										HNSCC(33;0.089)			31	132					0	0	0.001786	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766314	77766314	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:77766314G>A	uc003yav.2	+	10	7409	c.7022G>A	c.(7021-7023)GGG>GAG	p.G2341E	ZFHX4_uc003yau.1_Missense_Mutation_p.G2386E|ZFHX4_uc003yaw.1_Missense_Mutation_p.G2341E	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2341						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCTGGCTCTGGGACCAGCACC	0.522										HNSCC(33;0.089)			11	74					0	0	0.008291	0	0
CA2	760	broad.mit.edu	37	8	86386616	86386616	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:86386616G>A	uc003ydk.2	+	4	595	c.415G>A	c.(415-417)GGA>AGA	p.G139R		NM_000067	NP_000058	P00918	CAH2_HUMAN	carbonic anhydrase II	139					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(1)	1					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	GCAACCTGATGGACTGGCCGT	0.398													54	288					0	0	0.003610	0	0
SLC7A13	157724	broad.mit.edu	37	8	87229720	87229720	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:87229720G>A	uc003ydq.1	-	3	1256	c.1158C>T	c.(1156-1158)CCC>CCT	p.P386P	SLC7A13_uc003ydr.1_Silent_p.P377P	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	386	Cytoplasmic (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						TAGATAGATTGGGTTCCTGGT	0.284													19	81					0	0	0.001523	0	0
SLC7A13	157724	broad.mit.edu	37	8	87242302	87242302	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:87242302C>T	uc003ydq.1	-	1	303	c.205G>A	c.(205-207)GAG>AAG	p.E69K	SLC7A13_uc003ydr.1_Missense_Mutation_p.E69K	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	69	Cytoplasmic (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						ATACTTATCTCTGCAGAGCAA	0.468													18	72					0	0	0.004990	0	0
CNGB3	54714	broad.mit.edu	37	8	87588331	87588331	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:87588331C>T	uc003ydx.2	-	18	2177	c.2131G>A	c.(2131-2133)GAA>AAA	p.E711K	CNGB3_uc010maj.2_Missense_Mutation_p.E568K	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	711	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						tttccttcttcctctcctcct	0.149													10	32					0	0	0.006214	0	0
ESRP1	54845	broad.mit.edu	37	8	95680371	95680371	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:95680371C>T	uc003ygq.3	+	10	1309	c.1126C>T	c.(1126-1128)CTC>TTC	p.L376F	ESRP1_uc003ygr.3_Missense_Mutation_p.L376F|ESRP1_uc003ygs.3_Missense_Mutation_p.L376F|ESRP1_uc003ygt.3_Missense_Mutation_p.L376F|ESRP1_uc003ygu.3_Missense_Mutation_p.L376F|ESRP1_uc003ygv.2_Missense_Mutation_p.L216F|ESRP1_uc003ygw.2_Missense_Mutation_p.L216F	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	376	RRM 2.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						CGCTTTTGTCCTCTTTGCCTG	0.488													174	673					0	0	0.003610	0	0
DPY19L4	286148	broad.mit.edu	37	8	95777444	95777444	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:95777444C>T	uc003ygx.2	+	9	1028	c.904C>T	c.(904-906)CTC>TTC	p.L302F		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	302	Helical; (Potential).					integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					CATATTTTCCCTCTTTCTGGG	0.294													146	630					0	0	0.003610	0	0
MATN2	4147	broad.mit.edu	37	8	99019816	99019816	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:99019816G>A	uc003yic.2	+	10	1791	c.1560G>A	c.(1558-1560)GGG>GGA	p.G520G	MATN2_uc010mbh.1_Silent_p.G479G|MATN2_uc003yid.2_Silent_p.G520G|MATN2_uc003yie.1_Silent_p.G520G|MATN2_uc010mbi.1_Silent_p.G353G|MATN2_uc010mbj.1_Silent_p.G19G	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	520	EGF-like 7.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GCAGCGATGGGAAGACGTGTG	0.567													27	149					0	0	0.005443	0	0
MATN2	4147	broad.mit.edu	37	8	99045812	99045812	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:99045812G>A	uc003yic.2	+	18	2971	c.2740G>A	c.(2740-2742)GAT>AAT	p.D914N	MATN2_uc010mbh.1_Missense_Mutation_p.D873N|MATN2_uc003yid.2_Missense_Mutation_p.D895N|MATN2_uc003yie.1_Missense_Mutation_p.D914N|MATN2_uc010mbi.1_Missense_Mutation_p.D728N|MATN2_uc010mbj.1_Missense_Mutation_p.D275N|RPL30_uc010mbk.1_Intron	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	914						proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			AGAAAAACACGATCAATGCAA	0.388													7	28					0	0	0.004482	0	0
RGS22	26166	broad.mit.edu	37	8	101083691	101083691	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:101083691G>A	uc003yjb.1	-	6	695	c.500C>T	c.(499-501)CCC>CTC	p.P167L	RGS22_uc003yja.1_Intron|RGS22_uc003yjc.1_Missense_Mutation_p.P167L|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	167					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CACGATCCAGGGAGAAAAATT	0.378													21	110					0	0	0.002299	0	0
SPAG1	6674	broad.mit.edu	37	8	101243404	101243404	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:101243404C>G	uc003yjh.1	+	15	1962	c.1876C>G	c.(1876-1878)CTT>GTT	p.L626V	SPAG1_uc003yji.1_Missense_Mutation_p.L626V	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	626	TPR 7.				single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		ATTTAAAGCCCTTAAGGAAGA	0.318													32	180					0	0	0.002096	0	0
FZD6	8323	broad.mit.edu	37	8	104340522	104340522	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:104340522G>A	uc003ylh.2	+	5	1703	c.1419G>A	c.(1417-1419)TTG>TTA	p.L473L	FZD6_uc003yli.2_Silent_p.L473L|FZD6_uc003ylj.2_Silent_p.L473L|FZD6_uc011lhn.1_Silent_p.L439L|FZD6_uc011lho.1_Silent_p.L168L|FZD6_uc011lhp.1_Silent_p.L418L	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	473	Extracellular (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			GACCAGAATTGGCTTTATTTA	0.343													24	101					0	0	0.003954	0	0
RIMS2	9699	broad.mit.edu	37	8	104898211	104898211	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:104898211C>T	uc003yls.2	+	2	959	c.718C>T	c.(718-720)CCT>TCT	p.P240S	RIMS2_uc003ylp.2_Missense_Mutation_p.P462S|RIMS2_uc003ylw.2_Missense_Mutation_p.P270S|RIMS2_uc003ylq.2_Missense_Mutation_p.P270S|RIMS2_uc003ylr.2_Missense_Mutation_p.P270S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	493					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCACTTAGATCCTAGCTCTGC	0.468										HNSCC(12;0.0054)			22	81					0	0	0.001882	0	0
TM7SF4	81501	broad.mit.edu	37	8	105367188	105367188	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:105367188C>T	uc003ylx.1	+	3	1162	c.1113C>T	c.(1111-1113)TTC>TTT	p.F371F		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	371					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AACCAAAATTCCTTCTATCTG	0.353													35	79					0	0	0.003271	0	0
ABRA	137735	broad.mit.edu	37	8	107781950	107781950	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:107781950G>A	uc003ymm.3	-	1	523	c.469C>T	c.(469-471)CCA>TCA	p.P157S		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	157					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CTCCGCGTTGGGGAGCCGTGG	0.582													24	164					0	0	0.004656	0	0
KCNV1	27012	broad.mit.edu	37	8	110980497	110980497	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:110980497C>T	uc003ynr.3	-	3	1665	c.1323G>A	c.(1321-1323)AAG>AAA	p.K441K	KCNV1_uc010mcw.2_Silent_p.K441K	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	441	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CAGCTGCTTCCTTGAGTTTCA	0.428													37	65					0	0	0.004289	0	0
CSMD3	114788	broad.mit.edu	37	8	113364645	113364645	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:113364645C>T	uc003ynu.2	-	39	6414	c.6255G>A	c.(6253-6255)CAG>CAA	p.Q2085Q	CSMD3_uc003yns.2_Silent_p.Q1287Q|CSMD3_uc003ynt.2_Silent_p.Q2045Q|CSMD3_uc011lhx.1_Silent_p.Q1981Q	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2085	Extracellular (Potential).|Sushi 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATAGACTTACCTGAAGAGAAT	0.358										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	94					0	0	0.004990	0	0
CSMD3	114788	broad.mit.edu	37	8	113599463	113599463	+	Silent	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:113599463A>C	uc003ynu.2	-	23	3876	c.3717T>G	c.(3715-3717)GCT>GCG	p.A1239A	CSMD3_uc003yns.2_Silent_p.A511A|CSMD3_uc003ynt.2_Silent_p.A1199A|CSMD3_uc011lhx.1_Silent_p.A1135A	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1239	Sushi 6.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACCACATTCAGCTGCAGGTA	0.328										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	105					0	0	0.003163	0	0
CSMD3	114788	broad.mit.edu	37	8	113960098	113960098	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:113960098C>T	uc003ynu.2	-	9	1588	c.1429G>A	c.(1429-1431)GGA>AGA	p.G477R	CSMD3_uc003ynt.2_Missense_Mutation_p.G437R|CSMD3_uc011lhx.1_Missense_Mutation_p.G373R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	477	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTAATACCTCCCTCATTTACT	0.279										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	86					0	0	0.004482	0	0
TRPS1	7227	broad.mit.edu	37	8	116426751	116426751	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:116426751T>A	uc003ynz.2	-	6	3805	c.3346A>T	c.(3346-3348)AAA>TAA	p.K1116*	TRPS1_uc011lhy.1_Nonsense_Mutation_p.K1120*|TRPS1_uc003yny.2_Nonsense_Mutation_p.K1129*|TRPS1_uc010mcy.2_Nonsense_Mutation_p.K1116*	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	1116	Mediates interaction with RNF4 (By similarity).				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AGCTTATATTTACTCCAGAAC	0.473									Langer-Giedion_syndrome				16	52					0	0	0.003163	0	0
SLC30A8	169026	broad.mit.edu	37	8	118184920	118184920	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:118184920G>A	uc003yoh.2	+	8	1340	c.1110G>A	c.(1108-1110)TAG>TAA	p.*370*	SLC30A8_uc010mcz.2_Silent_p.*321*|SLC30A8_uc011lia.1_Silent_p.*321*|SLC30A8_uc003yog.2_Silent_p.*321*	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	370					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CCTGTGACTAGCTCAGTCACA	0.463													83	380					0	0	0.003610	0	0
COLEC10	10584	broad.mit.edu	37	8	120101955	120101955	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:120101955G>A	uc003yoo.2	+	2	282	c.185G>A	c.(184-186)GGA>GAA	p.G62E		NM_006438	NP_006429	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 precursor	62	Collagen-like.					collagen|cytoplasm	mannose binding			ovary(2)|skin(1)	3	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			GGAGAAGAGGGAAAGCATGGC	0.413													11	34					0	0	0.001855	0	0
COL14A1	7373	broad.mit.edu	37	8	121239556	121239556	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:121239556G>A	uc003yox.2	+	17	2367	c.2102G>A	c.(2101-2103)AGC>AAC	p.S701N	COL14A1_uc003yoy.2_Missense_Mutation_p.S379N	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	701	Fibronectin type-III 5.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GATGATGGAAGCGAGAGTGAG	0.512													23	148					0	0	0.004656	0	0
COL14A1	7373	broad.mit.edu	37	8	121383402	121383402	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:121383402G>A	uc003yox.2	+	48	5588	c.5323G>A	c.(5323-5325)GAT>AAT	p.D1775N		NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1775	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCCCCATCCAGATCAGCCAGA	0.522													33	212					0	0	0.004878	0	0
FAM83A	84985	broad.mit.edu	37	8	124195459	124195459	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:124195459G>A	uc003ypv.2	+	2	2377	c.363G>A	c.(361-363)TGG>TGA	p.W121*	FAM83A_uc003ypw.2_Nonsense_Mutation_p.W121*|FAM83A_uc003ypy.2_Nonsense_Mutation_p.W121*|FAM83A_uc003ypx.2_Nonsense_Mutation_p.W121*|FAM83A_uc003ypz.2_Nonsense_Mutation_p.W121*	NM_032899	NP_116288	Q86UY5	FA83A_HUMAN	hypothetical protein LOC84985 isoform a	121										ovary(3)|skin(1)	4	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			TGCACAGCTGGGCCTCAGCTG	0.612													27	119					0	0	0.001786	0	0
KLHL38	340359	broad.mit.edu	37	8	124659227	124659227	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:124659227A>G	uc003yqs.1	-	2	1402	c.1378T>C	c.(1378-1380)TTC>CTC	p.F460L		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	460	Kelch 4.										0						TCCATTTTGAACCACGAGTTT	0.433													45	201					0	0	0.003214	0	0
GSDMC	56169	broad.mit.edu	37	8	130772813	130772813	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:130772813A>C	uc003ysr.2	-	6	1581	c.699T>G	c.(697-699)GAT>GAG	p.D233E		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	233						mitochondrion				ovary(2)|skin(1)	3						TTCTCTGTTCATCATCATCTG	0.308													48	82					0	0	0.003610	0	0
OC90	729330	broad.mit.edu	37	8	133048632	133048632	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:133048632G>C	uc003ytg.2	-	8	665	c.665C>G	c.(664-666)ACT>AGT	p.T222S	OC90_uc011lix.1_Intron	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	238					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CTTGGAGAGAGTGATCAGTCT	0.443													12	142					0	0	0.007413	0	0
OC90	729330	broad.mit.edu	37	8	133051336	133051336	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:133051336G>A	uc003ytg.2	-	5	444	c.444C>T	c.(442-444)ACC>ACT	p.T148T	OC90_uc011lix.1_Silent_p.T164T	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	164	Phospholipase A2-like 1.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CCTTATCACAGGTACACAGCA	0.448													12	32					0	0	0.000978	0	0
TG	7038	broad.mit.edu	37	8	133899220	133899220	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:133899220C>T	uc003ytw.2	+	9	1644	c.1603C>T	c.(1603-1605)CCT>TCT	p.P535S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	535					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CACAGGAACCCCTGAAGCTGC	0.448													12	70					0	0	0.002450	0	0
TG	7038	broad.mit.edu	37	8	133900623	133900623	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:133900623C>T	uc003ytw.2	+	10	2612	c.2571C>T	c.(2569-2571)CCC>CCT	p.P857P		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	857	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGCCCCAGCCCAGGGAGAATA	0.552													11	83					0	0	0.001368	0	0
FAM135B	51059	broad.mit.edu	37	8	139164516	139164516	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:139164516T>G	uc003yuy.2	-	13	2373	c.2202A>C	c.(2200-2202)GAA>GAC	p.E734D	FAM135B_uc003yux.2_Missense_Mutation_p.E635D|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.E296D|FAM135B_uc003yvb.2_Missense_Mutation_p.E296D	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	734										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTGTGTTACTTTCTGTGTGTC	0.532										HNSCC(54;0.14)			6	65					0	0	0.001168	0	0
COL22A1	169044	broad.mit.edu	37	8	139674289	139674289	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:139674289C>T	uc003yvd.2	-	43	3671	c.3224G>A	c.(3223-3225)GGC>GAC	p.G1075D	COL22A1_uc011ljo.1_Missense_Mutation_p.G355D	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1075	Pro-rich.|Gly-rich.|Collagen-like 9.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GCCGGCTGGGCCCTGGGGGCC	0.547										HNSCC(7;0.00092)			14	114					0	0	0.002450	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141461203	141461204	+	Missense_Mutation	DNP	CT	TA	TA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:141461203_141461204CT>TA	uc003yvj.2	-	2	403_404	c.269_270AG>TA	c.(268-270)AAG>ATA	p.K90I	TRAPPC9_uc003yvh.2_Missense_Mutation_p.K188I|TRAPPC9_uc003yvi.1_Missense_Mutation_p.K90I	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	90					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						GTGGCCAGTCCTTGGCCGAGAA	0.579													19	85					0	0	0.004672	0	0
PTK2	5747	broad.mit.edu	37	8	141874443	141874443	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:141874443C>T	uc003yvu.2	-	5	648	c.418G>A	c.(418-420)GAT>AAT	p.D140N	PTK2_uc003yvr.2_Missense_Mutation_p.D39N|PTK2_uc003yvs.2_Missense_Mutation_p.D140N|PTK2_uc003yvt.2_Missense_Mutation_p.D162N|PTK2_uc003yvv.2_Missense_Mutation_p.D27N|PTK2_uc011ljr.1_Missense_Mutation_p.D140N	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	140	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			GTTGGCTTATCTTCAGTAAAC	0.264													38	132					0	0	0.002222	0	0
PTK2	5747	broad.mit.edu	37	8	141889609	141889609	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:141889609C>T	uc003yvu.2	-	4	553	c.323G>A	c.(322-324)AGG>AAG	p.R108K	PTK2_uc003yvr.2_Missense_Mutation_p.R7K|PTK2_uc003yvs.2_Missense_Mutation_p.R108K|PTK2_uc003yvt.2_Missense_Mutation_p.R130K|PTK2_uc003yvv.2_Intron|PTK2_uc011ljr.1_Missense_Mutation_p.R108K	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	108	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			ATACTTCTCCCTCACACTGGA	0.483													85	244					0	0	0.003610	0	0
DENND3	22898	broad.mit.edu	37	8	142146754	142146754	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:142146754C>T	uc003yvy.2	+	2	287	c.9C>T	c.(7-9)TCC>TCT	p.S3S	DENND3_uc003yvw.1_Silent_p.S16S|DENND3_uc003yvx.2_Silent_p.S83S|DENND3_uc010mep.2_Silent_p.S16S	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	3										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GGATGCGCTCCTTGAGAAAGA	0.612													4	33					0	0	0.000248	0	0
BAI1	575	broad.mit.edu	37	8	143623563	143623563	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:143623563G>A	uc003ywm.2	+	27	4151	c.3968G>A	c.(3967-3969)GGG>GAG	p.G1323E		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1323	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GTCGGTGACGGGGACATCTTC	0.672													28	168					0	0	0.007291	0	0
CYP11B2	1585	broad.mit.edu	37	8	143994088	143994088	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:143994088C>T	uc003yxk.1	-	8	1259	c.1256G>A	c.(1255-1257)AGG>AAG	p.R419K		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	419					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CCGCTCAGGCCTCGGGAACAA	0.617									Familial_Hyperaldosteronism_type_I				24	123					0	0	0.004656	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999085	143999086	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:143999085_143999086CC>TT	uc003yxk.1	-	1	174_175	c.171_172GG>AA	c.(169-174)AGGGAG>AGAAAG	p.E58K		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	58					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TAACCCTGCTCCCTCCAGATCT	0.634									Familial_Hyperaldosteronism_type_I				40	82					0	0	0.004672	0	0
ZC3H3	23144	broad.mit.edu	37	8	144557690	144557690	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144557690G>A	uc003yyd.2	-	5	1810	c.1781C>T	c.(1780-1782)CCT>CTT	p.P594L		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	594					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CCGCCACCAAGGGGAGCCCGG	0.642													9	25					0	0	0.004482	0	0
FAM83H	286077	broad.mit.edu	37	8	144809810	144809810	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144809810C>T	uc003yzk.2	-	5	1890	c.1821G>A	c.(1819-1821)GAG>GAA	p.E607E	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	607					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTTCGTAAGCCTCCGCTTCCA	0.736													3	17					0	0	0.004672	0	0
SCRIB	23513	broad.mit.edu	37	8	144893232	144893232	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144893232G>A	uc003yzp.1	-	11	1124	c.1117C>T	c.(1117-1119)CTG>TTG	p.L373L	SCRIB_uc003yzo.1_Silent_p.L373L	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	373	Sufficient for targeting to adherens junction and to inhibit cell proliferation.|LRR 15.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GCGAACGGCAGACTCTGCAGG	0.692													6	24					0	0	0.001984	0	0
PUF60	22827	broad.mit.edu	37	8	144899816	144899816	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144899816G>A	uc003yzs.2	-	9	1018	c.954C>T	c.(952-954)CTC>CTT	p.L318L	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Silent_p.L258L|PUF60_uc003yzt.2_Silent_p.L301L|PUF60_uc003yzq.2_Silent_p.L275L|PUF60_uc003yzu.1_Silent_p.L307L	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	318	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CGGCAGGTGGGAGGCCTCCAG	0.662													41	78					0	0	0.003610	0	0
EPPK1	83481	broad.mit.edu	37	8	144941802	144941802	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144941802G>A	uc003zaa.1	-	1	5633	c.5620C>T	c.(5620-5622)CGT>TGT	p.R1874C		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1874						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTCCCCACACGAAGTGTGTGC	0.607													21	101					0	0	0.001523	0	0
EPPK1	83481	broad.mit.edu	37	8	144946741	144946741	+	Silent	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144946741G>T	uc003zaa.1	-	1	694	c.681C>A	c.(679-681)GCC>GCA	p.A227A		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	227						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGGCAGCAAGGCTAGCCCCG	0.667													5	24					1.23904e-05	1.8807e-05	0.000602	1	0
HSF1	3297	broad.mit.edu	37	8	145535766	145535766	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:145535766C>T	uc003zbt.3	+	9	1148	c.978C>T	c.(976-978)TCC>TCT	p.S326S	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	326				S->A: Significant increase in transcriptional activity. No effect on DNA binding nor on nuclear translocation.		cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			CCCTCTTGTCCCCGACCGCCC	0.711													12	57					0	0	0.003163	0	0
FBXL6	26233	broad.mit.edu	37	8	145579751	145579751	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:145579751T>G	uc003zcb.2	-	8	1374	c.1349A>C	c.(1348-1350)CAG>CCG	p.Q450P	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_Missense_Mutation_p.Q177P|FBXL6_uc003zca.2_Missense_Mutation_p.Q444P|FBXL6_uc010mfx.2_Missense_Mutation_p.Q211P|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	450					proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			ACTGAACCCCTGGCCACTCAA	0.607													63	126					0	0	0.003610	0	0
RPL8	6132	broad.mit.edu	37	8	146015848	146015848	+	Silent	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:146015848C>A	uc003zeb.2	-	5	618	c.507G>T	c.(505-507)GTG>GTT	p.V169V	RPL8_uc003zdz.2_RNA|RPL8_uc003zea.2_Silent_p.V133V|RPL8_uc003zec.2_Silent_p.V169V	NM_033301	NP_150644	P62917	RL8_HUMAN	ribosomal protein L8	169					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	rRNA binding|structural constituent of ribosome				0	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.191)		CACCTCCAGCCACCACACCTG	0.577													20	128					3.62473e-10	5.51433e-10	0.001882	1	0
RPL8	6132	broad.mit.edu	37	8	146016825	146016825	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:146016825G>A	uc003zeb.2	-	4	447	c.336C>T	c.(334-336)ATC>ATT	p.I112I	RPL8_uc003zdz.2_RNA|RPL8_uc003zea.2_Silent_p.I76I|RPL8_uc003zec.2_Silent_p.I112I|RPL8_uc010mgc.2_3'UTR	NM_033301	NP_150644	P62917	RL8_HUMAN	ribosomal protein L8	112					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	rRNA binding|structural constituent of ribosome				0	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.191)		GGCAGCACACGATTGTACCCT	0.577													10	73					0	0	0.006214	0	0
GLIS3	169792	broad.mit.edu	37	9	3937169	3937169	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:3937169G>A	uc003zhw.1	-	4	1460	c.1266C>T	c.(1264-1266)GCC>GCT	p.A422A	GLIS3_uc003zhx.1_Silent_p.A577A|GLIS3_uc010mhf.1_5'UTR|GLIS3_uc003zhv.1_RNA|GLIS3_uc003zhy.1_Silent_p.A355A|GLIS3_uc003zhz.1_Silent_p.A355A	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	422	C2H2-type 3.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCCTTGAAAAGGCCTTCTCGC	0.448													26	61					0	0	0.005443	0	0
SLC1A1	6505	broad.mit.edu	37	9	4585528	4585528	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:4585528C>T	uc003zij.1	+	12	1781	c.1545C>T	c.(1543-1545)ACC>ACT	p.T515T	C9orf68_uc003zik.2_Intron	NM_004170	NP_004161	P43005	EAA3_HUMAN	solute carrier family 1, member 1	515					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	AGTCTGACACCATCTCATTCA	0.473													20	104					0	0	0.007413	0	0
PDCD1LG2	80380	broad.mit.edu	37	9	5549574	5549574	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:5549574G>A	uc003zjg.3	+	4	874	c.601G>A	c.(601-603)GAA>AAA	p.E201K	C9orf46_uc003zjd.2_Intron|PDCD1LG2_uc011lmc.1_Missense_Mutation_p.E201K|PDCD1LG2_uc011lmd.1_Missense_Mutation_p.E201K|PDCD1LG2_uc010mhp.1_Intron|PDCD1LG2_uc010mho.1_Intron	NM_025239	NP_079515	Q9BQ51	PD1L2_HUMAN	programmed cell death 1 ligand 2 precursor	201	Ig-like C2-type.|Extracellular (Potential).				immune response|T cell costimulation	endomembrane system|extracellular region|integral to membrane|plasma membrane	receptor activity				0	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000767)|Lung(218;0.112)		TCACGTGAGGGAACTTACTTT	0.428													12	46					0	0	0.001368	0	0
FREM1	158326	broad.mit.edu	37	9	14750232	14750232	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:14750232C>T	uc003zlm.2	-	30	6040	c.5450G>A	c.(5449-5451)GGA>GAA	p.G1817E	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_Intron|FREM1_uc003zll.2_Missense_Mutation_p.G353E	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1817	Calx-beta.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TTCCTCTAATCCGTCATAGGT	0.363													24	56					0	0	0.002299	0	0
FREM1	158326	broad.mit.edu	37	9	14801670	14801670	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:14801670G>A	uc003zlm.2	-	20	4264	c.3674C>T	c.(3673-3675)TCC>TTC	p.S1225F	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1225	CSPG 8.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GAGTTCCATGGAAAAGCTGTG	0.398													6	29					0	0	0.001168	0	0
C9orf93	203238	broad.mit.edu	37	9	15744360	15744360	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:15744360C>T	uc003zmd.2	+	17	2454	c.2139C>T	c.(2137-2139)TTC>TTT	p.F713F	C9orf93_uc010mih.1_Silent_p.F721F|C9orf93_uc003zme.2_Silent_p.F628F|C9orf93_uc011lmu.1_Silent_p.F721F|C9orf93_uc003zmf.1_Silent_p.F21F	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	713											0				GBM - Glioblastoma multiforme(50;4.84e-07)		ATTCGCACTTCAAAAAACTGT	0.393													34	72					0	0	0.002445	0	0
SH3GL2	6456	broad.mit.edu	37	9	17786423	17786423	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:17786423C>T	uc003zna.2	+	4	520	c.232C>T	c.(232-234)CGT>TGT	p.R78C	SH3GL2_uc011lmx.1_Missense_Mutation_p.R43C|SH3GL2_uc011lmy.1_Missense_Mutation_p.R31C	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	78	Required for dimerization upon membrane association (By similarity).|BAR.|Binds and tubulates liposomes (By similarity).				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		GTCAAAAATCCGTGGCCAGGA	0.507													33	40					0	0	0.004289	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777260	18777260	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:18777260G>A	uc003zne.3	+	19	3160	c.3033G>A	c.(3031-3033)CGG>CGA	p.R1011R		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1011						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CGGAGAAGCGGGGCCTGGCCG	0.706													10	6					0	0	0.008291	0	0
DENND4C	55667	broad.mit.edu	37	9	19342634	19342634	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:19342634T>G	uc003znq.2	+	17	2186	c.2153T>G	c.(2152-2154)GTG>GGG	p.V718G	DENND4C_uc011lnc.1_Missense_Mutation_p.V48G|DENND4C_uc011lnd.1_Missense_Mutation_p.V6G|DENND4C_uc003znr.2_Missense_Mutation_p.V6G|DENND4C_uc003zns.2_5'UTR	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	718						integral to membrane				ovary(1)|skin(1)	2						TTTCCAGAGGTGTGTGATGCC	0.378													27	33					0	0	0.008361	0	0
CDKN2A	1029	broad.mit.edu	37	9	21974720	21974720	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:21974720G>C	uc003zpk.2	-	1	319	c.107C>G	c.(106-108)GCG>GGG	p.A36G	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Missense_Mutation_p.A36G|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	36	ANK 1.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(23)|p.L32_L37del(6)|p.A36T(3)|p.G35fs*13(1)|p.V28_V51del(1)|p.A36fs*8(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GTTGGGCAGCGCCCCCGCCTC	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	78					0	0	0.006320	0	0
ELAVL2	1993	broad.mit.edu	37	9	23762245	23762245	+	Translation_Start_Site	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:23762245C>A	uc003zpu.2	-	2	263	c.-12G>T	c.(-14--10)CAGGT>CATGT		ELAVL2_uc003zps.2_Translation_Start_Site|ELAVL2_uc003zpt.2_Translation_Start_Site|ELAVL2_uc003zpv.2_Splice_Site|ELAVL2_uc003zpw.2_Splice_Site	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,						regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CAGCAATTACCTGCTAAAAAC	0.393													71	54					3.98911e-17	6.09074e-17	0.003610	1	0
PLAA	9373	broad.mit.edu	37	9	26920318	26920318	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:26920318A>C	uc003zqd.2	-	8	1529	c.1104T>G	c.(1102-1104)AGT>AGG	p.S368R	PLAA_uc003zqe.2_Missense_Mutation_p.S368R	NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	368	PFU.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		CTTCACTAACACTCCACTGAT	0.383													18	31					0	0	0.008871	0	0
LINGO2	158038	broad.mit.edu	37	9	27950484	27950484	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:27950484C>T	uc003zqu.1	-	2	380	c.186G>A	c.(184-186)TTG>TTA	p.L62L	LINGO2_uc010mjf.1_Silent_p.L62L|LINGO2_uc003zqv.1_Silent_p.L62L	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	62	LRR 1.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TACTGAGGTCCAAGATTTTGG	0.468													39	58					0	0	0.006230	0	0
TAF1L	138474	broad.mit.edu	37	9	32631360	32631360	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:32631360G>A	uc003zrg.1	-	1	4308	c.4218C>T	c.(4216-4218)TCC>TCT	p.S1406S	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1406					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		ACTCCAGGATGGATGACAGCG	0.448													68	103					0	0	0.003610	0	0
SMU1	55234	broad.mit.edu	37	9	33048158	33048158	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:33048158G>A	uc003zsf.1	-	11	1497	c.1389C>T	c.(1387-1389)GAC>GAT	p.D463D	SMU1_uc010mjo.1_Silent_p.D465D|SMU1_uc010mjp.1_Silent_p.D407D|SMU1_uc011lnu.1_Silent_p.D302D	NM_018225	NP_060695	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog	463						cytoplasm|nucleus				ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		AGAGCACAAAGTCCTCCCCTA	0.438													13	24					0	0	0.001368	0	0
KIAA1045	23349	broad.mit.edu	37	9	34972419	34972419	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:34972419G>A	uc003zvq.2	+	3	633	c.455G>A	c.(454-456)AGG>AAG	p.R152K	KIAA1045_uc003zvr.2_Missense_Mutation_p.R152K	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	152	PHD-type.						calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			GTCTGCACCAGGGTTTTCCAT	0.572													39	60					0	0	0.002222	0	0
PIGO	84720	broad.mit.edu	37	9	35093436	35093436	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:35093436G>A	uc003zwd.2	-	5	1317	c.921C>T	c.(919-921)TTC>TTT	p.F307F	PIGO_uc003zwc.1_Silent_p.F307F|PIGO_uc003zwe.2_Silent_p.F307F|PIGO_uc003zwf.2_Silent_p.F307F|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	307					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GGGTGCTGGGGAAGACTGCTG	0.537													12	21					0	0	0.002450	0	0
TLN1	7094	broad.mit.edu	37	9	35711666	35711666	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:35711666G>A	uc003zxt.2	-	29	4159	c.3805C>T	c.(3805-3807)CGA>TGA	p.R1269*		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1269					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CCTGAGGCTCGAGCCAGGTCC	0.602													47	114					0	0	0.003610	0	0
C9orf128	392307	broad.mit.edu	37	9	35825615	35825615	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:35825615C>T	uc010mlc.2	-	2	829	c.544G>A	c.(544-546)GGA>AGA	p.G182R	C9orf128_uc003zyj.2_RNA|C9orf128_uc011lpg.1_Missense_Mutation_p.G182R	NM_001012446	NP_001012448	A6H8Z2	CI128_HUMAN	hypothetical protein LOC392307	182											0	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			GCATCTACTCCCTTTTCAACC	0.502											OREG0019180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	119					0	0	0.007835	0	0
RECK	8434	broad.mit.edu	37	9	36122903	36122903	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:36122903T>A	uc003zyv.2	+	21	2863	c.2777T>A	c.(2776-2778)CTC>CAC	p.L926H	RECK_uc003zyw.2_Missense_Mutation_p.L798H|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	926						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			CATGTCCCTCTCTCTGCCCTC	0.557													32	110					0	0	0.004878	0	0
FRMPD1	22844	broad.mit.edu	37	9	37744757	37744757	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:37744757G>A	uc004aag.1	+	16	2772	c.2728G>A	c.(2728-2730)GAG>AAG	p.E910K	FRMPD1_uc004aah.1_Missense_Mutation_p.E910K	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	910						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		TCCTCTGAGGGAGACCAAGAG	0.582													17	37					0	0	0.004007	0	0
IGFBPL1	347252	broad.mit.edu	37	9	38411496	38411496	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:38411496G>A	uc004aba.2	-	4	761	c.738C>T	c.(736-738)GCC>GCT	p.A246A		NM_001007563	NP_001007564	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like	246	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding				0				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		CCACCATGTTGGCTGCATGGC	0.488													18	38					0	0	0.008871	0	0
PRKACG	5568	broad.mit.edu	37	9	71628097	71628097	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:71628097G>A	uc004agy.2	-	1	943	c.912C>T	c.(910-912)ATC>ATT	p.I304I		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	304	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						CATAGATGGCGATCCAGCTGG	0.572													24	93					0	0	0.004656	0	0
PRKACG	5568	broad.mit.edu	37	9	71628130	71628130	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:71628130C>T	uc004agy.2	-	1	910	c.879G>A	c.(877-879)AAG>AAA	p.K293K		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	293	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						ACTTGTGGTTCTTGATGTCGC	0.572													116	11					0	0	0.003610	0	0
TRPM3	80036	broad.mit.edu	37	9	73230967	73230967	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:73230967G>A	uc004aid.2	-	17	2591	c.2347C>T	c.(2347-2349)CCT>TCT	p.P783S	TRPM3_uc004ahu.2_Missense_Mutation_p.P613S|TRPM3_uc004ahv.2_Missense_Mutation_p.P585S|TRPM3_uc004ahw.2_Missense_Mutation_p.P655S|TRPM3_uc004ahx.2_Missense_Mutation_p.P642S|TRPM3_uc004ahy.2_Missense_Mutation_p.P645S|TRPM3_uc004ahz.2_Missense_Mutation_p.P632S|TRPM3_uc004aia.2_Missense_Mutation_p.P630S|TRPM3_uc004aib.2_Missense_Mutation_p.P620S|TRPM3_uc004aic.2_Missense_Mutation_p.P783S	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	808	Helical; (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AGAATTGAAGGAGGAAGTAGA	0.373													7	21					0	0	0.001984	0	0
TMC1	117531	broad.mit.edu	37	9	75404142	75404142	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:75404142G>A	uc004aiz.1	+	15	1673	c.1133G>A	c.(1132-1134)GGG>GAG	p.G378E	TMC1_uc010moz.1_Missense_Mutation_p.G336E|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.G232E|TMC1_uc010mpa.1_Missense_Mutation_p.G232E	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	378	Helical; (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						ACACTTGGAGGGAGTGGATAC	0.463													21	41					0	0	0.008871	0	0
PSAT1	29968	broad.mit.edu	37	9	80921351	80921351	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:80921351G>A	uc004ala.2	+	5	587	c.519G>A	c.(517-519)CTG>CTA	p.L173L	PSAT1_uc004alb.2_Silent_p.L173L	NM_058179	NP_478059	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1 isoform 1	173					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	GAGCAGTACTGGTTTGTGACA	0.502													256	36					0	0	0.003610	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88918036	88918036	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:88918036G>A	uc004aoq.2	-	25	4274	c.4059C>T	c.(4057-4059)ATC>ATT	p.I1353I	ZCCHC6_uc010mqe.2_Silent_p.I253I|ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Silent_p.I1117I|ZCCHC6_uc004aou.2_Silent_p.I1353I	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	1353	CCHC-type 2.				RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TGAAGTGTCCGATTTTTCCAC	0.348													52	71					0	0	0.003610	0	0
CDK20	23552	broad.mit.edu	37	9	90586062	90586062	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:90586062C>T	uc004apr.2	-	3	684	c.378G>A	c.(376-378)CGG>CGA	p.R126R	CDK20_uc004aps.2_Silent_p.R126R|CDK20_uc004apt.2_Silent_p.R139R|CDK20_uc004apu.2_Silent_p.R126R	NM_001039803	NP_001034892	Q8IZL9	CDK20_HUMAN	cell cycle related kinase isoform 3	126	Protein kinase.				cell division|multicellular organismal development	cilium|mitochondrion|nucleus	ATP binding|cyclin-dependent protein kinase activity			skin(1)	1						TGAGACTGACCCGATGTACAA	0.577													8	13					0	0	0.004482	0	0
IARS	3376	broad.mit.edu	37	9	94984883	94984883	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:94984883C>T	uc004art.1	-	33	3882	c.3625G>A	c.(3625-3627)GGT>AGT	p.G1209S	IARS_uc004ars.1_Missense_Mutation_p.G1002S|IARS_uc004aru.3_Missense_Mutation_p.G1209S|IARS_uc010mqr.2_Missense_Mutation_p.G1099S|IARS_uc010mqt.2_Missense_Mutation_p.G432S	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	1209					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	TACAGAAGACCTTGGTGGGTG	0.498													73	102					0	0	0.003610	0	0
IARS	3376	broad.mit.edu	37	9	95004508	95004508	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:95004508G>A	uc004art.1	-	29	3362	c.3105C>T	c.(3103-3105)ACC>ACT	p.T1035T	IARS_uc004ars.1_Silent_p.T880T|IARS_uc004aru.3_Silent_p.T1035T|IARS_uc010mqr.2_Silent_p.T925T|IARS_uc010mqt.2_Silent_p.T258T	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	1035					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	CCTTTATGGTGGTAAATATGA	0.383													21	31					0	0	0.001523	0	0
FGD3	89846	broad.mit.edu	37	9	95738957	95738957	+	Missense_Mutation	SNP	C	T	T	rs71496423		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:95738957C>T	uc004asw.2	+	3	1047	c.419C>T	c.(418-420)CCC>CTC	p.P140L	FGD3_uc004asx.2_Missense_Mutation_p.P140L|FGD3_uc004asz.2_Missense_Mutation_p.P140L	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	140					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						GAGAACACCCCCCAGAAGGCT	0.647													12	12					0	0	0.002450	0	0
CDC14B	8555	broad.mit.edu	37	9	99296774	99296774	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:99296774G>A	uc004awj.2	-	8	1130	c.678C>T	c.(676-678)GCC>GCT	p.A226A	CDC14B_uc004awk.2_Silent_p.A226A|CDC14B_uc004awl.2_RNA|CDC14B_uc004awi.2_Silent_p.A189A	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	226	B.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GTCCACAGAAGGCAATAAATC	0.348													14	24					0	0	0.004990	0	0
KIAA1529	57653	broad.mit.edu	37	9	100132243	100132244	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:100132243_100132244CC>TT	uc011lut.1	+	44	5551_5552	c.4778_4779CC>TT	c.(4777-4779)CCC>CTT	p.P1593L	KIAA1529_uc004axe.1_Missense_Mutation_p.P1399L|KIAA1529_uc004axg.1_Missense_Mutation_p.P1454L|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.P547L	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				GAGCTGCTGCCCCAAGTGTGTT	0.5													9	20					0	0	0.004672	0	0
GALNT12	79695	broad.mit.edu	37	9	101589065	101589065	+	Silent	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:101589065T>A	uc004ayz.2	+	3	573	c.573T>A	c.(571-573)CTT>CTA	p.L191L		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	191	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				CCAATGAGCTTTCGGGACTGC	0.647													16	2					0	0	0.004990	0	0
NR4A3	8013	broad.mit.edu	37	9	102590329	102590329	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:102590329C>T	uc004baf.1	+	3	734	c.5C>T	c.(4-6)CCC>CTC	p.P2L	NR4A3_uc004bae.2_Missense_Mutation_p.P2L|NR4A3_uc004bag.1_Missense_Mutation_p.P2L|NR4A3_uc004bai.2_Missense_Mutation_p.P13L	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	2					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				GCAGATATGCCCTGCGTCCAA	0.512			T	EWSR1	extraskeletal myxoid chondrosarcoma								16	29					0	0	0.003163	0	0
ACTL7A	10881	broad.mit.edu	37	9	111625832	111625832	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:111625832G>A	uc004bdj.1	+	1	1230	c.1230G>A	c.(1228-1230)CAG>CAA	p.Q410Q		NM_006687	NP_006678	Q9Y615	ACL7A_HUMAN	actin-like 7A	410						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton				0						CCTCACTTCAGGGTTTCCAAC	0.562													50	6					0	0	0.003610	0	0
SVEP1	79987	broad.mit.edu	37	9	113173765	113173765	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:113173765G>A	uc010mtz.2	-	37	6563	c.6226C>T	c.(6226-6228)CCC>TCC	p.P2076S	SVEP1_uc010mty.2_Missense_Mutation_p.P2S	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2076	Sushi 11.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ATACAACGGGGCATGTCTTGA	0.483													23	2					0	0	0.001882	0	0
SVEP1	79987	broad.mit.edu	37	9	113205957	113205957	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:113205957G>C	uc010mtz.2	-	27	4844	c.4507C>G	c.(4507-4509)CCC>GCC	p.P1503A	SVEP1_uc010mua.1_Missense_Mutation_p.P1503A	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1503	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TTCACCGAGGGACAGTTTGTT	0.433													9	15					0	0	0.001368	0	0
ZNF483	158399	broad.mit.edu	37	9	114304657	114304657	+	Missense_Mutation	SNP	C	T	T	rs149958964	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:114304657C>T	uc004bff.2	+	6	1666	c.1442C>T	c.(1441-1443)TCG>TTG	p.S481L	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	481	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						GATAGTTCATCGCTCACACCA	0.418													16	18					0	0	0.004007	0	0
FKBP15	23307	broad.mit.edu	37	9	115932877	115932877	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:115932877G>A	uc004bgs.2	-	25	2809	c.2691C>T	c.(2689-2691)TCC>TCT	p.S897S	FKBP15_uc004bgr.2_Silent_p.S334S|FKBP15_uc011lxc.1_Silent_p.S478S|FKBP15_uc011lxd.1_Silent_p.S829S	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	897					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						CTCTCCGTAAGGACTGGAACA	0.443													39	69					0	0	0.002222	0	0
RNF183	138065	broad.mit.edu	37	9	116060000	116060000	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:116060000G>A	uc004bgz.2	-	2	583	c.465C>T	c.(463-465)TTC>TTT	p.F155F	RNF183_uc004bha.2_Silent_p.F155F	NM_145051	NP_659488	Q96D59	RN183_HUMAN	ring finger protein 183	155						integral to membrane	zinc ion binding				0						GAGGGTTGCGGAAACACTCCC	0.587													40	3					0	0	0.003214	0	0
DBC1	1620	broad.mit.edu	37	9	121929406	121929406	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:121929406C>T	uc004bkc.2	-	8	2698	c.2242G>A	c.(2242-2244)GAG>AAG	p.E748K		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	748					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TTGAGGATCTCCGTGTTGTAC	0.488													62	93					0	0	0.003610	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123165332	123165332	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:123165332G>A	uc004bkf.2	-	34	5240	c.5059C>T	c.(5059-5061)CTC>TTC	p.L1687F	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.L696F|CDK5RAP2_uc004bke.2_Missense_Mutation_p.L972F|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.L1608F|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.L952F|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.L952F|CDK5RAP2_uc011lya.1_Missense_Mutation_p.L952F|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.L1457F	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1687					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						TTCCCAGAGAGTGGAGGAGTC	0.522													14	28					0	0	0.003163	0	0
OR1N2	138882	broad.mit.edu	37	9	125316009	125316009	+	Silent	SNP	C	G	G	rs140908671		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:125316009C>G	uc011lyx.1	+	1	561	c.561C>G	c.(559-561)GCC>GCG	p.A187A		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						CTTTCTGTGCCCAGAAAGCCA	0.537													39	8					0	0	0.004878	0	0
DENND1A	57706	broad.mit.edu	37	9	126144641	126144642	+	Missense_Mutation	DNP	GG	AA	AA	rs149511328		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:126144641_126144642GG>AA	uc004bnz.1	-	22	2332_2333	c.2099_2100CC>TT	c.(2098-2100)CCC>CTT	p.P700L	DENND1A_uc011lzl.1_Missense_Mutation_p.P518L|DENND1A_uc004bny.1_Missense_Mutation_p.P482L|DENND1A_uc011lzm.1_Missense_Mutation_p.P711L|DENND1A_uc010mwh.1_Missense_Mutation_p.P121L	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	700	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						CTTGGGGCCGGGGGATGGTGAT	0.693													11	6					0	0	0.004672	0	0
LHX2	9355	broad.mit.edu	37	9	126783392	126783392	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:126783392G>A	uc004boe.1	+	4	1481	c.742G>A	c.(742-744)GAA>AAA	p.E248K	LHX2_uc010mwi.1_Missense_Mutation_p.E256K	NM_004789	NP_004780	P50458	LHX2_HUMAN	LIM homeobox protein 2	248						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AAGCTGCAACGAAAACGACGC	0.612													16	3					0	0	0.004990	0	0
PTGES2	80142	broad.mit.edu	37	9	130883435	130883435	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:130883435G>A	uc004bti.2	-	7	1601	c.1123C>T	c.(1123-1125)CCA>TCA	p.P375S	uc004btg.1_5'Flank|PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_Missense_Mutation_p.P184S|PTGES2_uc004btl.2_Missense_Mutation_p.P184S|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	375	GST C-terminal.|Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0						CAGTGCGCTGGGGAGGCCTCG	0.672													5	5					0	0	0.003080	0	0
TTF1	7270	broad.mit.edu	37	9	135277532	135277532	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:135277532G>A	uc004cbl.2	-	2	729	c.677C>T	c.(676-678)TCC>TTC	p.S226F	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	226					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CCGGTTACTGGACTTTTTCTT	0.502													30	7					0	0	0.008361	0	0
SURF6	6838	broad.mit.edu	37	9	136199576	136199576	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:136199576G>A	uc004cdb.3	-	4	492	c.414C>T	c.(412-414)TCC>TCT	p.S138S		NM_006753	NP_006744	O75683	SURF6_HUMAN	surfeit 6	138						granular component	DNA binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		AGGCGGCAGGGGACAGCTCCT	0.602													23	31					0	0	0.002780	0	0
KIAA0649	9858	broad.mit.edu	37	9	138379983	138379983	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:138379983C>T	uc004cfr.1	+	4	4176	c.3627C>T	c.(3625-3627)GTC>GTT	p.V1209V		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	1209						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		TAGTGAAGGTCTAAGCCCTCG	0.617													23	4					0	0	0.002780	0	0
GLT6D1	360203	broad.mit.edu	37	9	138516324	138516324	+	Silent	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:138516324A>G	uc010nbd.1	-	5	704	c.450T>C	c.(448-450)CAT>CAC	p.H150H		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	150	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		GGCTCTTCACATGCACCAGGG	0.562													4	18					0	0	0.000248	0	0
SNAPC4	6621	broad.mit.edu	37	9	139273392	139273392	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:139273392G>A	uc004chh.2	-	21	2896	c.2887C>T	c.(2887-2889)CCT>TCT	p.P963S		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	963	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GAAGTGCCAGGTTTGGCTGCC	0.667													13	12					0	0	0.001368	0	0
ABCA2	20	broad.mit.edu	37	9	139910620	139910620	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:139910620G>A	uc011mem.1	-	21	3256	c.3108C>T	c.(3106-3108)ATC>ATT	p.I1036I	ABCA2_uc011mel.1_Silent_p.I1037I|ABCA2_uc004ckl.1_Silent_p.I967I|ABCA2_uc004ckm.1_Silent_p.I1067I|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1036	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGCCGGTCAGGATGGACCTGG	0.657													18	24					0	0	0.001882	0	0
TPRN	286262	broad.mit.edu	37	9	140093724	140093725	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:140093724_140093725CC>TT	uc004clt.2	-	1	1256_1257	c.1256_1257GG>AA	c.(1255-1257)AGG>AAA	p.R419K	TPRN_uc004clu.2_Missense_Mutation_p.R419K	NM_173691	NP_775962	Q4KMQ1	TPRN_HUMAN	hypothetical protein LOC286262 isoform 2	480					sensory perception of sound	stereocilium					0						GGTGCAGAGGCCTGGCAGGGTG	0.653													19	29					0	0	0.004672	0	0
CACNA1B	774	broad.mit.edu	37	9	141012397	141012397	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:141012397G>A	uc004cog.2	+	42	5923	c.5778_splice	c.e42-1	p.I1926_splice	CACNA1B_uc004coi.2_Splice_Site_p.I1138_splice	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,						membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTCTGCCACAGACAAAACCAA	0.567													12	0					0	0	0.002450	0	0
ASMT	438	broad.mit.edu	37	X	1761794	1761794	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:1761794G>A	uc004cqd.2	+	10	1154	c.1009G>A	c.(1009-1011)GGG>AGG	p.G337R	ASMT_uc010ncy.2_Missense_Mutation_p.G337R|ASMT_uc004cqe.2_Missense_Mutation_p.G262R	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	309					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCAGACGGAAGGGCAGGAGAG	0.517													25	117					0	0	0.003954	0	0
MXRA5	25878	broad.mit.edu	37	X	3239522	3239522	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:3239522C>T	uc004crg.3	-	5	4361	c.4204G>A	c.(4204-4206)GAA>AAA	p.E1402K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1402						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTAAGATTTTCCCCAGAAGTG	0.507													8	2					0	0	0.003080	0	0
MXRA5	25878	broad.mit.edu	37	X	3261814	3261814	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:3261814G>A	uc004crg.3	-	2	218	c.61C>T	c.(61-63)CCG>TCG	p.P21S		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	21						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCCACTCGCGGATGGCCCCAA	0.662													4	0					0	0	0.000248	0	0
TLR7	51284	broad.mit.edu	37	X	12906412	12906412	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:12906412G>A	uc004cvc.2	+	3	2924	c.2785G>A	c.(2785-2787)GAG>AAG	p.E929K		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	929	TIR.|Cytoplasmic (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	TTTATGTCTCGAGGAAAGGGA	0.468													77	7					0	0	0.003610	0	0
TLR8	51311	broad.mit.edu	37	X	12939932	12939932	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:12939932G>A	uc004cve.2	+	2	2841	c.2773G>A	c.(2773-2775)GGA>AGA	p.G925R	TLR8_uc004cvd.2_Missense_Mutation_p.G943R	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	925	Cytoplasmic (Potential).|TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TTGGGATCCGGGATTGGCCAT	0.433													38	4					0	0	0.003214	0	0
NHS	4810	broad.mit.edu	37	X	17745857	17745857	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:17745857G>A	uc004cxx.2	+	6	3906	c.3568G>A	c.(3568-3570)GGA>AGA	p.G1190R	NHS_uc011mix.1_Missense_Mutation_p.G1211R|NHS_uc004cxy.2_Missense_Mutation_p.G1034R|NHS_uc004cxz.2_Missense_Mutation_p.G1013R|NHS_uc004cya.2_Missense_Mutation_p.G913R	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1190						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					AGTTGAGATGGGACCAGATAA	0.393													45	5					0	0	0.003610	0	0
RAI2	10742	broad.mit.edu	37	X	17818801	17818801	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:17818801C>T	uc004cyf.2	-	3	1900	c.1330G>A	c.(1330-1332)GAA>AAA	p.E444K	RAI2_uc004cyg.2_Missense_Mutation_p.E444K|RAI2_uc010nfa.2_Missense_Mutation_p.E444K|RAI2_uc004cyh.3_Missense_Mutation_p.E444K|RAI2_uc011miy.1_Missense_Mutation_p.E394K	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	444					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					ACAGCATCTTCGACAGAGACA	0.537													80	15					0	0	0.003610	0	0
CXorf58	254158	broad.mit.edu	37	X	23956695	23956695	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:23956695C>T	uc004daz.1	+	8	1161	c.817C>T	c.(817-819)CGG>TGG	p.R273W	CXorf58_uc011mju.1_Missense_Mutation_p.R273W	NM_152761	NP_689974	Q96LI9	CX058_HUMAN	hypothetical protein LOC254158	273											0						ACCTCTATATCGGCCCTACAA	0.333													51	3					0	0	0.003610	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998711	27998711	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:27998711G>A	uc004dbx.1	-	1	856	c.741C>T	c.(739-741)TTC>TTT	p.F247F		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	247	WD 2.									ovary(3)|skin(1)	4						AGTTAGGAAAGAACTTAGCCT	0.473													25	4					0	0	0.008361	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999123	27999123	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:27999123T>A	uc004dbx.1	-	1	444	c.329A>T	c.(328-330)GAA>GTA	p.E110V		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	110	Glu-rich.									ovary(3)|skin(1)	4						ctcctccccttcctcctccat	0.393													21	3					0	0	0.008871	0	0
CXorf21	80231	broad.mit.edu	37	X	30578040	30578040	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:30578040G>A	uc004dcg.1	-	3	709	c.433C>T	c.(433-435)CCC>TCC	p.P145S		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	145										ovary(1)	1						CTCTCAGAGGGAAAATCTGTT	0.433													22	4					0	0	0.002299	0	0
CYBB	1536	broad.mit.edu	37	X	37668882	37668882	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:37668882G>A	uc004ddr.2	+	12	1585	c.1524G>A	c.(1522-1524)AAG>AAA	p.K508K	CYBB_uc011mkf.1_Silent_p.K476K|CYBB_uc011mkg.1_Silent_p.K241K	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	508	Cytoplasmic (Potential).				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						TGAAACAAAAGACTTTGTATG	0.423													9	0					0	0	0.004482	0	0
USP9X	8239	broad.mit.edu	37	X	41075159	41075159	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:41075159C>T	uc004dfb.2	+	35	5972	c.5339C>T	c.(5338-5340)ACC>ATC	p.T1780I	USP9X_uc004dfc.2_Missense_Mutation_p.T1780I	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1780					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TAGGTTGATACCGTAAAGCGC	0.323													12	1					0	0	0.003163	0	0
DDX3X	1654	broad.mit.edu	37	X	41204721	41204721	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:41204721C>T	uc004dfe.2	+	12	2090	c.1235C>T	c.(1234-1236)TCT>TTT	p.S412F	DDX3X_uc004dff.2_Missense_Mutation_p.S412F|DDX3X_uc011mkq.1_Missense_Mutation_p.S396F|DDX3X_uc011mkr.1_Intron|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	412	Necessary for interaction with XPO1.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						GGCTCTACCTCTGAAAACATC	0.353										HNSCC(61;0.18)			24	4					0	0	0.005443	0	0
CASK	8573	broad.mit.edu	37	X	41416311	41416311	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:41416311G>A	uc004dfl.3	-	19	1826	c.1780C>T	c.(1780-1782)CAT>TAT	p.H594Y	CASK_uc004dfj.3_Intron|CASK_uc004dfk.3_Missense_Mutation_p.H409Y|CASK_uc004dfm.3_Intron|CASK_uc004dfn.3_Intron	NM_003688	NP_003679	O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein	594					cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			ovary(3)|lung(2)|stomach(1)	6						GTGCTGCTATGACCATTAGCT	0.433													21	2					0	0	0.006320	0	0
SLC9A7	84679	broad.mit.edu	37	X	46466519	46466519	+	Silent	SNP	G	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:46466519G>T	uc004dgu.1	-	17	2054	c.2046C>A	c.(2044-2046)TCC>TCA	p.S682S		NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	682					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						CCAGACTCGTGGAGGCGGTGT	0.597													10	1					6.40141e-05	9.69018e-05	0.000978	1	0
USP11	8237	broad.mit.edu	37	X	47106768	47106768	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:47106768A>T	uc004dhp.2	+	19	2615	c.2615A>T	c.(2614-2616)TAT>TTT	p.Y872F	USP11_uc004dhq.2_Missense_Mutation_p.Y598F	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	872					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CTGTACAAATATGACCTCATC	0.572													16	3					0	0	0.008871	0	0
Unknown	0	broad.mit.edu	37	X	51149989	51149989	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:51149989C>T	uc004dpj.2	+	1	223	c.121C>T	c.(121-123)CCT>TCT	p.P41S		NM_203407	NP_981952			hypothetical protein LOC340602																		GAATCAAGATCCTGCTGCTTC	0.662													11	0					0	0	0.001368	0	0
ITIH5L	347365	broad.mit.edu	37	X	54783453	54783453	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:54783453G>A	uc004dtj.2	-	8	3084	c.3054C>T	c.(3052-3054)TTC>TTT	p.F1018F		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	1018					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						AGGACTCCACGAACTTGGATT	0.522													14	0					0	0	0.004990	0	0
TRO	7216	broad.mit.edu	37	X	54957352	54957352	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:54957352G>A	uc004dtq.2	+	12	4302	c.4195G>A	c.(4195-4197)GGA>AGA	p.G1399R	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_RNA|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.G930R|TRO_uc004dtw.2_Missense_Mutation_p.G1002R|TRO_uc004dtx.2_Missense_Mutation_p.G782R	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1399	62 X 10 AA approximate tandem repeats.|59; approximate.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						CTTCGGCGGTGGACCAAACAC	0.617													29	3					0	0	0.008361	0	0
FAM123B	139285	broad.mit.edu	37	X	63410326	63410327	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:63410326_63410327GG>AA	uc004dvo.2	-	2	3113_3114	c.2840_2841CC>TT	c.(2839-2841)TCC>TTT	p.S947F		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	947					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CAGTATAGAGGGAAAGGGGACT	0.589													6	1					0	0	0.004672	0	0
MTMR8	55613	broad.mit.edu	37	X	63564991	63564991	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:63564991G>A	uc004dvs.2	-	7	867	c.799C>T	c.(799-801)CGC>TGC	p.R267C	MTMR8_uc011mou.1_Missense_Mutation_p.R267C|MTMR8_uc004dvt.1_Missense_Mutation_p.R267C	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	267	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						AATCTGAAGCGAATGTTGGCA	0.488													26	4					0	0	0.004656	0	0
LAS1L	81887	broad.mit.edu	37	X	64743512	64743512	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:64743512G>A	uc004dwa.1	-	11	1448	c.1376C>T	c.(1375-1377)TCC>TTC	p.S459F	LAS1L_uc004dwc.1_Missense_Mutation_p.S442F|LAS1L_uc004dwd.1_Missense_Mutation_p.S400F	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	459						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						CCAGTCAAGGGAGGCGGAGCA	0.577													4	1					0	0	0.000248	0	0
AWAT2	158835	broad.mit.edu	37	X	69262176	69262176	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:69262176G>A	uc004dxt.1	-	6	714	c.708C>T	c.(706-708)TTC>TTT	p.F236F		NM_001002254	NP_001002254	Q6E213	AWAT2_HUMAN	wax synthase 2	236						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity				0						CACCAGGAGTGAAAATGTGCT	0.498													15	5					0	0	0.004990	0	0
GDPD2	54857	broad.mit.edu	37	X	69646512	69646512	+	Silent	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:69646512C>T	uc004dyh.2	+	7	728	c.477C>T	c.(475-477)TTC>TTT	p.F159F	GDPD2_uc010nkx.1_Silent_p.F159F|GDPD2_uc010nky.1_5'UTR|GDPD2_uc011mpk.1_Silent_p.F159F|GDPD2_uc011mpl.1_Silent_p.F80F|GDPD2_uc011mpm.1_Silent_p.F80F	NM_017711	NP_060181	Q9HCC8	GDPD2_HUMAN	osteoblast differentiation promoting factor	159	Helical; (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			ovary(2)	2	Renal(35;0.156)					CAGCCCCATTCCTTCATATTG	0.607													7	0					0	0	0.003080	0	0
RGAG4	340526	broad.mit.edu	37	X	71349749	71349749	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:71349749G>A	uc010nlh.1	-	1	2003	c.1642C>T	c.(1642-1644)CCT>TCT	p.P548S	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	548										ovary(2)|skin(1)	3	Renal(35;0.156)					AAAAGCACAGGGGGGCGTCTT	0.602													25	2					0	0	0.003330	0	0
PHKA1	5255	broad.mit.edu	37	X	71802346	71802346	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:71802346G>A	uc004eax.3	-	31	3701	c.3400C>T	c.(3400-3402)CTC>TTC	p.L1134F	PHKA1_uc004eay.3_Missense_Mutation_p.L1121F|PHKA1_uc011mqi.1_Missense_Mutation_p.L1062F|PHKA1_uc010nll.2_Missense_Mutation_p.L166F	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	1134					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					AGCATGGTGAGGACAAGGATG	0.453													20	3					0	0	0.008871	0	0
ATP7A	538	broad.mit.edu	37	X	77300981	77300981	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:77300981A>G	uc004ecx.3	+	22	4298	c.4138A>G	c.(4138-4140)ATT>GTT	p.I1380V		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1380	Extracellular (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TTTTATGCCCATTGGTTTGGT	0.343													61	15					0	0	0.003610	0	0
GPR174	84636	broad.mit.edu	37	X	78427122	78427122	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:78427122G>A	uc004edg.1	+	1	654	c.618G>A	c.(616-618)TGG>TGA	p.W206*		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	206	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						ATTGTACCTGGAAGACGGTTT	0.453										HNSCC(63;0.18)			29	2					0	0	0.005443	0	0
MCART6	401612	broad.mit.edu	37	X	103349732	103349732	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:103349732C>T	uc004elu.2	-	2	390	c.209G>A	c.(208-210)TGG>TAG	p.W70*		NM_001012755	NP_001012773	Q5H9E4	MCAR6_HUMAN	mitochondrial carrier triple repeat 6	70	Solcar 1.				transport	integral to membrane|mitochondrial inner membrane					0						ACCTTCATGCCAAAGCTGTCT	0.478													21	6					0	0	0.001882	0	0
CAPN6	827	broad.mit.edu	37	X	110494250	110494250	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:110494250C>A	uc004epc.1	-	8	1221	c.1053G>T	c.(1051-1053)AAG>AAT	p.K351N	CAPN6_uc011msu.1_Missense_Mutation_p.K96N	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	351	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						ATTCCAGCTCCTTTCGGCCAA	0.502													156	14					7.04978e-92	1.0818e-91	0.003610	1	0
ZCCHC12	170261	broad.mit.edu	37	X	117959676	117959676	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:117959676C>T	uc004equ.2	+	4	942	c.469C>T	c.(469-471)CAG>TAG	p.Q157*		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						ggtgcagctccagaacgctat	0.109													50	7					0	0	0.003610	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128902303	128902303	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:128902303G>A	uc004eut.1	+	21	2111	c.1867G>A	c.(1867-1869)GAG>AAG	p.E623K		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	623					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						GACCATCCGGGAGAAGGTGGG	0.602													19	2					0	0	0.002299	0	0
F9	2158	broad.mit.edu	37	X	138623299	138623299	+	Silent	SNP	C	G	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:138623299C>G	uc004fas.1	+	4	371	c.342C>G	c.(340-342)TCC>TCG	p.S114S	F9_uc004fat.1_Intron	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	114	EGF-like 1; calcium-binding (Potential).				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	ACATTAATTCCTATGAATGTT	0.368													22	4					0	0	0.002780	0	0
CDR1	1038	broad.mit.edu	37	X	139866474	139866474	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:139866474G>A	uc004fbg.1	-	1	250	c.58C>T	c.(58-60)CCT>TCT	p.P20S	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	20	23 X 6 AA approximate repeats.|3.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				TCCAACAAAGGTATGTCTTCC	0.423													98	14					0	0	0.003610	0	0
GABRE	2564	broad.mit.edu	37	X	151130954	151130954	+	Silent	SNP	G	A	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:151130954G>A	uc004ffi.2	-	4	558	c.504C>T	c.(502-504)ATC>ATT	p.I168I	GABRE_uc011myd.1_RNA|GABRE_uc011mye.1_RNA|MIR452_hsa-mir-452|MI0001733_5'Flank	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	168	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TGGGCATGGTGATCTCATGCT	0.483													31	4					0	0	0.001786	0	0
MAGEA1	4100	broad.mit.edu	37	X	152482458	152482458	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:152482458C>T	uc004fhf.2	-	3	773	c.553G>A	c.(553-555)GAT>AAT	p.D185N		NM_004988	NP_004979	P43355	MAGA1_HUMAN	melanoma antigen family A, 1	185	MAGE.					cytoplasm|plasma membrane				central_nervous_system(7)|ovary(1)|lung(1)|breast(1)	10	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ATCTGATTATCACCCAGCAGG	0.547													42	6					0	0	0.003610	0	0
NLGN4Y	22829	broad.mit.edu	37	Y	16936239	16936239	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrY:16936239C>T	uc004ftg.2	+	4	1049	c.797C>T	c.(796-798)TCC>TTC	p.S266F	NLGN4Y_uc004fte.2_Missense_Mutation_p.S98F|NLGN4Y_uc011nas.1_Missense_Mutation_p.S286F|NLGN4Y_uc004ftf.2_5'UTR|NLGN4Y_uc004fth.2_Missense_Mutation_p.S266F	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	266	Extracellular (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						TTGACCCTGTCCCACTACTCA	0.542													19	17					0	0	0.001523	0	0
RBMY2EP	159125	broad.mit.edu	37	Y	23563366	23563366	+	RNA	SNP	C	T	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrY:23563366C>T	uc004fun.1	-	1		c.83G>A				NR_001574				Homo sapiens RNA binding motif protein, Y-linked, family 2, member E pseudogene (RBMY2EP), non-coding RNA.												0						GGGTTACCTTCTGATATGGGA	0.289													9	0					0	0	0.006214	0	0
PIK3CD	5293	broad.mit.edu	37	1	9770521	9770526	+	In_Frame_Del	DEL	CTGGGG	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:9770521_9770526delCTGGGG	uc001aqb.3	+	3	216_221	c.8_13delCTGGGG	c.(7-15)CCTGGGGTG>CTG	p.3_5PGV>L	PIK3CD_uc001aqa.2_In_Frame_Del_p.3_5PGV>L|PIK3CD_uc010oaf.1_In_Frame_Del_p.3_5PGV>L|PIK3CD_uc001aqe.3_In_Frame_Del_p.3_5PGV>L	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	3_5					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		AGGATGCCCCCTGGGGTGGACTGCCC	0.529													20	128	---	---	---	---					
C1QC	714	broad.mit.edu	37	1	22973763	22973763	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:22973763delG	uc001bgc.3	+	3	328	c.225delG	c.(223-225)AAGfs	p.K75fs	C1QC_uc001bga.3_Frame_Shift_Del_p.K75fs|C1QC_uc001bgb.2_Frame_Shift_Del_p.K75fs	NM_172369	NP_758957	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	75	Collagen-like.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen					0		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AAGGGCAGAAGGGAGAACCCG	0.493													12	34	---	---	---	---					
IL25	64806	broad.mit.edu	37	14	23845057	23845058	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:23845057_23845058delTG	uc001wjr.2	+	2	812_813	c.502_503delTG	c.(502-504)TGTfs	p.C168fs	IL25_uc001wjq.2_Frame_Shift_Del_p.C152fs|CMTM5_uc001wjs.2_5'Flank|CMTM5_uc001wjt.2_5'Flank|CMTM5_uc010akm.2_5'Flank|CMTM5_uc010akn.2_5'Flank|CMTM5_uc001wju.2_5'Flank|CMTM5_uc010ako.2_5'Flank	NM_022789	NP_073626	Q9H293	IL25_HUMAN	interleukin 25 isoform 1 precursor	168					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			ovary(1)	1	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		TTCCTTAGCTTGTGTGTGTGTG	0.604													7	69	---	---	---	---					
ADAM21	8747	broad.mit.edu	37	14	70924869	70924871	+	In_Frame_Del	DEL	ATG	-	-	rs141326765		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:70924869_70924871delATG	uc001xmd.2	+	1	653_655	c.653_655delATG	c.(652-657)CATGAT>CAT	p.D219del		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	219	Peptidase M12B.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GTGGTGAACCATGATTTCTTCAT	0.414													8	43	---	---	---	---					
CCDC40	55036	broad.mit.edu	37	17	78055757	78055757	+	Frame_Shift_Del	DEL	C	-	-	rs61749058	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:78055757delC	uc010dht.2	+	12	1916	c.1889delC	c.(1888-1890)GCTfs	p.A630fs	CCDC40_uc002jxm.3_Frame_Shift_Del_p.A413fs|CCDC40_uc002jxn.3_Frame_Shift_Del_p.A26fs	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	630					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AAGACGGATGCTGCCATCCGG	0.562													10	27	---	---	---	---					
LRRTM1	347730	broad.mit.edu	37	2	80529507	80529518	+	In_Frame_Del	DEL	TCTGATGCATGG	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:80529507_80529518delTCTGATGCATGG	uc002sok.1	-	2	1697_1708	c.1427_1438delCCATGCATCAGA	c.(1426-1440)ACCATGCATCAGATG>ATG	p.TMHQ476del	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	476_479	Cytoplasmic (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						ATGGCAGCCATCTGATGCATGGTCTGTTTCTG	0.538										HNSCC(69;0.2)			15	30	---	---	---	---					
HERC3	8916	broad.mit.edu	37	4	89601295	89601295	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:89601295delT	uc003hrw.1	+	20	2414	c.2248delT	c.(2248-2250)TTTfs	p.F750fs	HERC3_uc011cdn.1_Frame_Shift_Del_p.F632fs|HERC3_uc011cdo.1_Frame_Shift_Del_p.F194fs	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	750					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TACAAAGGAATTTTTTCTTTT	0.343													22	24	---	---	---	---					
ZFR	51663	broad.mit.edu	37	5	32419951	32419953	+	In_Frame_Del	DEL	GGT	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:32419951_32419953delGGT	uc003jhr.1	-	3	473_475	c.393_395delACC	c.(391-396)CCACCC>CCC	p.131_132PP>P	ZFR_uc010iun.1_In_Frame_Del_p.131_132PP>P	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	131_132	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		AGTAGCTGGGGGTGGTGGTGGTG	0.483													7	218	---	---	---	---					
MAPK9	5601	broad.mit.edu	37	5	179665329	179665349	+	Splice_Site	DEL	AACCTGAAGGCTGATCTTTTA	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:179665329_179665349delAACCTGAAGGCTGATCTTTTA	uc003mls.3	-	11	1403	c.1132_splice	c.e11+1	p.D378_splice	MAPK9_uc003mlt.3_Splice_Site_p.A378_splice|MAPK9_uc010jlc.2_Splice_Site_p.D378_splice|MAPK9_uc003mlv.3_Splice_Site_p.A378_splice	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2						innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCAATCACTAACCTGAAGGCTGATCTTTTACAACACCATT	0.231													9	155	---	---	---	---					
OR6W1P	89883	broad.mit.edu	37	7	142759847	142759847	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:142759847delA	uc003wce.1	-	1	1036	c.577delT	c.(577-579)TCCfs	p.S193fs		NR_002140				SubName: Full=HCG1646325; SubName: Full=Seven transmembrane helix receptor;											central_nervous_system(1)|skin(1)	2						CCAGAGGAGGAAGGGATGTGC	0.567													2	4	---	---	---	---					
HR	55806	broad.mit.edu	37	8	21978407	21978407	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:21978407delT	uc003xas.2	-	11	3097	c.2432delA	c.(2431-2433)GAGfs	p.E811fs	HR_uc003xat.2_Frame_Shift_Del_p.E811fs	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	811							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CAGGGCTTTCTCCTGGATCTT	0.677													2	4	---	---	---	---					
PLEKHF2	79666	broad.mit.edu	37	8	96166414	96166414	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:96166414delA	uc003yhn.1	+	2	389	c.142delA	c.(142-144)AAAfs	p.K48fs		NM_024613	NP_078889	Q9H8W4	PKHF2_HUMAN	phafin 2	48	PH.					transport vesicle	metal ion binding|protein binding			ovary(2)	2	Breast(36;3.18e-05)					GTTGTGCAGGAAAAAGCCCAA	0.343													7	1090	---	---	---	---					
CIZ1	25792	broad.mit.edu	37	9	130953109	130953111	+	In_Frame_Del	DEL	GCT	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:130953109_130953111delGCT	uc004btt.2	-	2	189_191	c.26_28delAGC	c.(25-30)CAGCTC>CTC	p.Q9del	CIZ1_uc004btr.2_In_Frame_Del_p.Q9del|CIZ1_uc004bts.2_In_Frame_Del_p.Q9del|CIZ1_uc011maq.1_In_Frame_Del_p.Q9del|CIZ1_uc004btu.2_In_Frame_Del_p.Q9del|CIZ1_uc011mar.1_5'UTR|CIZ1_uc011mas.1_In_Frame_Del_p.Q39del|CIZ1_uc004btw.2_In_Frame_Del_p.Q9del|CIZ1_uc004btv.2_In_Frame_Del_p.Q9del|CIZ1_uc004btx.2_In_Frame_Del_p.Q9del	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	9	Gln-rich.			Missing (in Ref. 7; AAF23231).		nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4						tgttgctggagctgctgctgctg	0.330													3	5	---	---	---	---					
NRK	203447	broad.mit.edu	37	X	105137893	105137893	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:105137893delA	uc004emd.2	+	6	750	c.447delA	c.(445-447)TTAfs	p.L149fs	NRK_uc010npc.1_5'UTR	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	149	Protein kinase.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						ATCAGAGTTTAAAAGAAGATT	0.383										HNSCC(51;0.14)			18	4	---	---	---	---					
