Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
MMEL1	79258	broad.mit.edu	37	1	2526897	2526898	+	Intron	INS	-	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2526897_2526898insG	uc001ajy.2	-						MMEL1_uc009vlg.1_Intron	NM_033467	NP_258428			membrane metallo-endopeptidase-like 1						proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)														---	---	---	---
CA6	765	broad.mit.edu	37	1	9028023	9028029	+	Intron	DEL	TTTTTTT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9028023_9028029delTTTTTTT	uc001apm.2	+						CA6_uc009vmn.2_Intron	NM_001215	NP_001206			carbonic anhydrase VI precursor						one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
UBE4B	10277	broad.mit.edu	37	1	10114789	10114789	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10114789delT	uc001aqs.3	+						UBE4B_uc001aqr.3_Intron|UBE4B_uc010oai.1_Intron|UBE4B_uc010oaj.1_Intron	NM_001105562	NP_001099032			ubiquitination factor E4B isoform 1						apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)														---	---	---	---
FBXO44	93611	broad.mit.edu	37	1	11721002	11721002	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11721002delT	uc001asm.2	+						FBXO44_uc001ask.2_Intron|FBXO44_uc001asl.2_Intron|FBXO44_uc001asn.2_Intron|FBXO44_uc010oar.1_Intron|FBXO44_uc010oas.1_Intron	NM_033182	NP_149438			F-box protein 44 isoform 1						protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
TNFRSF8	943	broad.mit.edu	37	1	12198204	12198204	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12198204delA	uc001atq.2	+						TNFRSF8_uc010obc.1_Intron|TNFRSF8_uc001atr.2_Intron|TNFRSF8_uc001ats.2_Intron	NM_001243	NP_001234			tumor necrosis factor receptor superfamily,						cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
VPS13D	55187	broad.mit.edu	37	1	12330940	12330941	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12330940_12330941delTT	uc001atv.2	+						VPS13D_uc001atw.2_Intron	NM_015378	NP_056193			vacuolar protein sorting 13D isoform 1						protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)														---	---	---	---
VPS13D	55187	broad.mit.edu	37	1	12414424	12414424	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12414424delA	uc001atv.2	+						VPS13D_uc001atw.2_Intron|VPS13D_uc001atx.2_Intron	NM_015378	NP_056193			vacuolar protein sorting 13D isoform 1						protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)														---	---	---	---
FBLIM1	54751	broad.mit.edu	37	1	16103389	16103390	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16103389_16103390insA	uc001axd.1	+						FBLIM1_uc001axe.1_Intron|FBLIM1_uc001axf.2_Intron|FBLIM1_uc001axh.1_Intron|FBLIM1_uc001axi.1_Intron	NM_017556	NP_060026			filamin-binding LIM protein-1 isoform a						cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)														---	---	---	---
FBXO42	54455	broad.mit.edu	37	1	16579419	16579419	+	Intron	DEL	A	-	-	rs34091640		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16579419delA	uc001ayg.2	-						FBXO42_uc001aye.3_Intron|FBXO42_uc001ayf.2_Intron	NM_018994	NP_061867			F-box protein 42											upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	17345217	17345217	+	IGR	DEL	T	-	-	rs75557632		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17345217delT								ATP13A2 (6794 upstream) : SDHB (10 downstream)																																			---	---	---	---
UBR4	23352	broad.mit.edu	37	1	19439932	19439932	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19439932delA	uc001bbi.2	-						UBR4_uc001bbj.1_3'UTR	NM_020765	NP_065816			retinoblastoma-associated factor 600						interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)												OREG0013168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MUL1	79594	broad.mit.edu	37	1	20829892	20829892	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:20829892delT	uc001bdi.3	-							NM_024544	NP_078820			mitochondrial ubiquitin ligase activator of NFKB						activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)														---	---	---	---
KDM1A	23028	broad.mit.edu	37	1	23382691	23382691	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23382691delT	uc001bgi.2	+						KDM1A_uc001bgj.2_Intron	NM_015013	NP_055828			lysine-specific histone demethylase 1 isoform b						blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2																		---	---	---	---
ASAP3	55616	broad.mit.edu	37	1	23762668	23762668	+	Intron	DEL	T	-	-	rs77206819		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23762668delT	uc001bha.2	-						ASAP3_uc001bgy.1_Intron|ASAP3_uc001bgz.1_Intron|ASAP3_uc010odz.1_Intron|ASAP3_uc010oea.1_Intron|ASAP3_uc001bhb.2_Intron	NM_017707	NP_060177			ArfGAP with SH3 domain, ankyrin repeat and PH						regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
CATSPER4	378807	broad.mit.edu	37	1	26528147	26528147	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26528147delT	uc010oez.1	+						CATSPER4_uc009vsf.2_Intron	NM_198137	NP_937770			cation channel, sperm associated 4						cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PHACTR4	65979	broad.mit.edu	37	1	28817970	28817970	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28817970delA	uc001bpw.2	+						PHACTR4_uc001bpv.1_Intron|PHACTR4_uc001bpx.2_Intron|PHACTR4_uc001bpy.2_Intron|PHACTR4_uc001bpz.2_5'Flank	NM_001048183	NP_001041648			phosphatase and actin regulator 4 isoform 1								actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CDCA8	55143	broad.mit.edu	37	1	38170966	38170966	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38170966delT	uc001cbr.2	+						CDCA8_uc001cbs.2_Intron|CDCA8_uc010oih.1_Intron	NM_018101	NP_060571			cell division cycle associated 8						cell division|chromosome organization|mitotic metaphase|mitotic prometaphase	chromosome passenger complex|chromosome, centromeric region|cytosol|nucleolus|spindle	protein binding			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)																---	---	---	---
KDM4A	9682	broad.mit.edu	37	1	44133253	44133253	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44133253delT	uc001cjx.2	+						KDM4A_uc010oki.1_Intron	NM_014663	NP_055478			jumonji domain containing 2A						interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1																		---	---	---	---
EPS15	2060	broad.mit.edu	37	1	51829866	51829866	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51829866delA	uc001csq.1	-						EPS15_uc009vyz.1_Intron|EPS15_uc001csp.3_Intron	NM_001981	NP_001972			epidermal growth factor receptor pathway						cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2								T	MLL	ALL								---	---	---	---
EPS15	2060	broad.mit.edu	37	1	51929637	51929638	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51929637_51929638insA	uc001csq.1	-						EPS15_uc009vyz.1_Intron	NM_001981	NP_001972			epidermal growth factor receptor pathway						cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2								T	MLL	ALL								---	---	---	---
SORT1	6272	broad.mit.edu	37	1	109883200	109883201	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109883200_109883201delAA	uc001dxm.1	-						SORT1_uc010ovi.1_Intron	NM_002959	NP_002950			sortilin 1 preproprotein						endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)														---	---	---	---
DRAM2	128338	broad.mit.edu	37	1	111663004	111663029	+	Intron	DEL	AAAAAAAAAAAAAAAAAAAAAAAAAA	-	-	rs71751427		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111663004_111663029delAAAAAAAAAAAAAAAAAAAAAAAAAA	uc001ead.3	-						DRAM2_uc001eae.3_Intron|DRAM2_uc009wfy.2_Intron|DRAM2_uc001eaf.3_Intron	NM_178454	NP_848549			transmembrane protein 77						apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane					0																		---	---	---	---
ST7L	54879	broad.mit.edu	37	1	113126864	113126864	+	Intron	DEL	A	-	-	rs76579294		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113126864delA	uc001ecd.2	-						ST7L_uc009wgh.2_Intron|ST7L_uc001ecc.2_Intron|ST7L_uc010owg.1_Intron|ST7L_uc010owh.1_Intron|ST7L_uc001ece.2_Intron|ST7L_uc001ecf.2_Intron|ST7L_uc001ecg.2_Intron|ST7L_uc010owi.1_Intron|ST7L_uc001ech.2_Intron|ST7L_uc001eci.2_Intron|ST7L_uc009wgi.1_Intron|ST7L_uc010owj.1_Intron	NM_017744	NP_060214			suppression of tumorigenicity 7-like isoform 1						negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
PHTF1	10745	broad.mit.edu	37	1	114281008	114281009	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114281008_114281009delAA	uc009wgp.1	-						PHTF1_uc001edn.2_Intron|PHTF1_uc010own.1_Intron|PHTF1_uc001edp.2_Intron	NM_006608	NP_006599			putative homeodomain transcription factor 1							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
PRKAB2	5565	broad.mit.edu	37	1	146633145	146633145	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:146633145delA	uc001epe.2	-						PRKAB2_uc010ozm.1_Intron|PRKAB2_uc010ozn.1_Intron|PRKAB2_uc009wjf.1_3'UTR	NM_005399	NP_005390			AMP-activated protein kinase beta 2						carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				lung(2)|skin(1)	3	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)													---	---	---	---
BCL9	607	broad.mit.edu	37	1	147091501	147091501	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:147091501delC	uc001epq.2	+	8	2280	c.1540delC	c.(1540-1542)CCCfs	p.P514fs	BCL9_uc010ozr.1_Frame_Shift_Del_p.P440fs	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	514	Poly-Pro.|Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)							T	IGH@|IGL@	B-ALL								---	---	---	---
GABPB2	126626	broad.mit.edu	37	1	151062748	151062748	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151062748delT	uc001ewr.2	+						GABPB2_uc010pcp.1_Intron|GABPB2_uc001ews.2_Intron|GABPB2_uc001ewt.2_5'Flank	NM_144618	NP_653219			GA repeat binding protein, beta 2						positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein heterodimerization activity|transcription regulatory region DNA binding				0				all cancers(107;7.17e-05)|GBM - Glioblastoma multiforme(94;0.000662)														---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	153995962	153995962	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153995962delT	uc001fdw.2	-						NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191			nucleoporin 210kDa-like isoform 1							integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
Unknown	0	broad.mit.edu	37	1	155568529	155568529	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155568529delA								LOC645676 (34797 upstream) : MSTO1 (11478 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	160640180	160640180	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160640180delT								SLAMF1 (23099 upstream) : CD48 (8358 downstream)																																			---	---	---	---
SH2D1B	117157	broad.mit.edu	37	1	162372713	162372715	+	Intron	DEL	TTC	-	-	rs3122549	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:162372713_162372715delTTC	uc001gbz.1	-						SH2D1B_uc001gca.1_Intron	NM_053282	NP_444512			SH2 domain containing 1B											pancreas(1)	1	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)															---	---	---	---
RC3H1	149041	broad.mit.edu	37	1	173930736	173930736	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173930736delA	uc001gju.3	-						RC3H1_uc010pms.1_Intron|RC3H1_uc001gjv.2_Intron|RC3H1_uc010pmt.1_Intron	NM_172071	NP_742068			roquin						cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
RABGAP1L	9910	broad.mit.edu	37	1	174721308	174721308	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174721308delA	uc001gjx.2	+						RABGAP1L_uc001gkb.3_Intron|RABGAP1L_uc001gkc.3_Intron|RABGAP1L_uc001gkd.3_Intron	NM_014857	NP_055672			RAB GTPase activating protein 1-like isoform A						regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186077432	186077432	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186077432delA	uc001grq.1	+							NM_031935	NP_114141			hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
RGS13	6003	broad.mit.edu	37	1	192613357	192613357	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:192613357delT	uc001gsj.2	+						RGS13_uc001gsk.2_Intron	NM_002927	NP_002918			regulator of G-protein signalling 13							plasma membrane	GTPase activator activity|signal transducer activity				0																		---	---	---	---
KIF14	9928	broad.mit.edu	37	1	200573204	200573204	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200573204delT	uc010ppk.1	-						KIF14_uc010ppj.1_Intron	NM_014875	NP_055690			kinesin family member 14						microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7																		---	---	---	---
PIK3C2B	5287	broad.mit.edu	37	1	204414942	204414942	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204414942delA	uc001haw.2	-						PIK3C2B_uc010pqv.1_Intron	NM_002646	NP_002637			phosphoinositide-3-kinase, class 2 beta						cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)															---	---	---	---
SRGAP2	23380	broad.mit.edu	37	1	206592577	206592578	+	Intron	INS	-	TC	TC			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:206592577_206592578insTC	uc001hdy.2	+						SRGAP2_uc010prt.1_Intron|SRGAP2_uc001hdx.2_Intron|SRGAP2_uc010pru.1_Intron|SRGAP2_uc010prv.1_Intron	NM_015326	NP_056141			SLIT-ROBO Rho GTPase activating protein 2						axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)																	---	---	---	---
INTS7	25896	broad.mit.edu	37	1	212180337	212180337	+	Intron	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212180337delC	uc001hiw.1	-						INTS7_uc009xdb.1_Intron|INTS7_uc001hix.1_Intron|INTS7_uc001hiy.1_Intron|INTS7_uc010pta.1_Intron	NM_015434	NP_056249			integrator complex subunit 7						snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)														---	---	---	---
FLVCR1	28982	broad.mit.edu	37	1	213058893	213058897	+	Intron	DEL	TTTTT	-	-	rs72199951		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:213058893_213058897delTTTTT	uc001hjt.2	+							NM_014053	NP_054772			feline leukemia virus subgroup C cellular						cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)														---	---	---	---
RPS6KC1	26750	broad.mit.edu	37	1	213290507	213290507	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:213290507delT	uc010ptr.1	+						RPS6KC1_uc001hkd.2_Intron|RPS6KC1_uc010pts.1_Intron|RPS6KC1_uc010ptt.1_Intron|RPS6KC1_uc010ptu.1_Intron|RPS6KC1_uc010ptv.1_Intron|RPS6KC1_uc001hke.2_Intron	NM_012424	NP_036556			ribosomal protein S6 kinase, 52kDa, polypeptide						cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)														---	---	---	---
KCTD3	51133	broad.mit.edu	37	1	215749407	215749407	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215749407delT	uc001hks.2	+						KCTD3_uc001hkt.2_Intron|KCTD3_uc010pub.1_Intron|KCTD3_uc009xdn.2_5'Flank	NM_016121	NP_057205			potassium channel tetramerisation domain							voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)														---	---	---	---
MIA3	375056	broad.mit.edu	37	1	222806145	222806145	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:222806145delT	uc001hnl.2	+						MIA3_uc009xea.1_Intron	NM_198551	NP_940953			melanoma inhibitory activity family, member 3						exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)														---	---	---	---
CDC42BPA	8476	broad.mit.edu	37	1	227213676	227213676	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:227213676delA	uc001hqr.2	-						CDC42BPA_uc001hqq.2_Intron|CDC42BPA_uc001hqs.2_Intron|CDC42BPA_uc009xes.2_Intron|CDC42BPA_uc010pvs.1_Intron|CDC42BPA_uc001hqp.2_Intron|CDC42BPA_uc001hqt.2_Intron|CDC42BPA_uc001hqu.1_Intron	NM_003607	NP_003598			CDC42-binding protein kinase alpha isoform B						actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)																---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237924231	237924232	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237924231_237924232delTT	uc001hyl.1	+						RYR2_uc010pya.1_Intron	NM_001035	NP_001026			cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
C1orf101	257044	broad.mit.edu	37	1	244751608	244751608	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:244751608delA	uc001iam.2	+						C1orf101_uc001iak.1_Intron|C1orf101_uc001ial.2_Intron|C1orf101_uc010pym.1_Intron|C1orf101_uc010pyn.1_Intron	NM_001130957	NP_001124429			hypothetical protein LOC257044 isoform 1							integral to membrane				ovary(1)|breast(1)	2	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)															---	---	---	---
DDX1	1653	broad.mit.edu	37	2	15739606	15739606	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:15739606delT	uc002rce.2	+						DDX1_uc010yjq.1_Intron	NM_004939	NP_004930			DEAD (Asp-Glu-Ala-Asp) box polypeptide 1						DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)														---	---	---	---
WDR35	57539	broad.mit.edu	37	2	20141611	20141611	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20141611delA	uc002rdi.2	-						WDR35_uc002rdj.2_Intron|WDR35_uc010ext.2_Intron|WDR35_uc002rdh.2_Intron|WDR35_uc002rdk.3_Intron	NM_001006657	NP_001006658			WD repeat domain 35 isoform 1											ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
WDR35	57539	broad.mit.edu	37	2	20174176	20174178	+	Intron	DEL	AAA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20174176_20174178delAAA	uc002rdi.2	-						WDR35_uc002rdj.2_Intron|WDR35_uc010ext.2_Intron|WDR35_uc002rdh.2_Intron	NM_001006657	NP_001006658			WD repeat domain 35 isoform 1											ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
PUM2	23369	broad.mit.edu	37	2	20454512	20454512	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20454512delA	uc002rds.1	-						PUM2_uc002rdq.1_Intron|PUM2_uc002rdt.1_Intron|PUM2_uc002rdr.2_Intron|PUM2_uc010yjy.1_Intron|PUM2_uc002rdu.1_Intron|PUM2_uc010yjz.1_Intron	NM_015317	NP_056132			pumilio homolog 2						regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32690110	32690111	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32690110_32690111delTT	uc010ezu.2	+							NM_016252	NP_057336			baculoviral IAP repeat-containing 6						anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32820253	32820253	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32820253delT	uc010ezu.2	+							NM_016252	NP_057336			baculoviral IAP repeat-containing 6						anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
Unknown	0	broad.mit.edu	37	2	38294353	38294353	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38294353delA								FAM82A1 (73 upstream) : CYP1B1 (393 downstream)																																			---	---	---	---
THADA	63892	broad.mit.edu	37	2	43513865	43513865	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:43513865delA	uc002rsw.3	-						THADA_uc010far.2_Intron|THADA_uc002rsx.3_Intron|THADA_uc002rsy.3_Intron	NM_001083953	NP_001077422			thyroid adenoma associated								binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)																---	---	---	---
THADA	63892	broad.mit.edu	37	2	43624983	43624983	+	Intron	DEL	A	-	-	rs77307304		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:43624983delA	uc002rsw.3	-						THADA_uc010far.2_Intron|THADA_uc002rsx.3_Intron|THADA_uc002rsy.3_Intron|THADA_uc010fas.1_Intron|THADA_uc002rsz.2_Intron	NM_001083953	NP_001077422			thyroid adenoma associated								binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)																---	---	---	---
PAPOLG	64895	broad.mit.edu	37	2	61009700	61009700	+	Intron	DEL	A	-	-	rs113987431		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61009700delA	uc002sai.2	+						PAPOLG_uc002saj.2_Intron|PAPOLG_uc002sak.2_Intron|PAPOLG_uc010fch.2_Intron	NM_022894	NP_075045			poly(A) polymerase gamma						mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)															---	---	---	---
PUS10	150962	broad.mit.edu	37	2	61171973	61171973	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61171973delA	uc010fci.2	-						PUS10_uc002sao.2_Intron|PUS10_uc010ypk.1_Intron	NM_144709	NP_653310			pseudouridylate synthase 10						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(2)|large_intestine(1)|kidney(1)	4			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)															---	---	---	---
USP34	9736	broad.mit.edu	37	2	61431179	61431179	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61431179delA	uc002sbe.2	-						USP34_uc002sbd.2_Intron	NM_014709	NP_055524			ubiquitin specific protease 34						positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)															---	---	---	---
EXOC6B	23233	broad.mit.edu	37	2	72723735	72723735	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:72723735delG	uc010fep.2	-						EXOC6B_uc002sij.2_Intron	NM_015189	NP_056004			SEC15-like 2						protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2																		---	---	---	---
ST3GAL5	8869	broad.mit.edu	37	2	86067102	86067102	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86067102delA	uc002sqq.1	-	7					ST3GAL5_uc010fgq.1_3'UTR|ST3GAL5_uc002sqp.1_3'UTR	NM_003896	NP_003887			ST3 beta-galactoside alpha-2,3-sialyltransferase						ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity				0																		---	---	---	---
IMMT	10989	broad.mit.edu	37	2	86393771	86393773	+	Intron	DEL	AAA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86393771_86393773delAAA	uc002sqz.3	-						IMMT_uc002sqy.3_Intron|IMMT_uc002srb.3_Intron|IMMT_uc002sra.3_Intron|IMMT_uc010ytd.1_Intron|IMMT_uc010yte.1_Intron|IMMT_uc002src.1_Intron|IMMT_uc002srd.2_Intron|IMMT_uc002sre.3_Intron|IMMT_uc010ytf.1_Intron|IMMT_uc010fgs.1_Intron	NM_006839	NP_006830			inner membrane protein, mitochondrial isoform 1							integral to mitochondrial inner membrane	protein binding			skin(1)	1																		---	---	---	---
ANKRD20B	729171	broad.mit.edu	37	2	95457981	95457981	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95457981delA	uc010fhp.2	-							NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0																		---	---	---	---
TBC1D8	11138	broad.mit.edu	37	2	101624787	101624788	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:101624787_101624788delTT	uc010fiv.2	-						RPL31_uc010yvu.1_Intron|RPL31_uc010yvv.1_Intron|RPL31_uc010fiu.1_Intron|TBC1D8_uc002tau.3_Intron	NM_001102426	NP_001095896			TBC1 domain family, member 8						blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	106863863	106863863	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:106863863delA								UXS1 (53068 upstream) : PLGLA (138906 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	2	106987360	106987360	+	IGR	DEL	T	-	-	rs78019139		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:106987360delT								UXS1 (176565 upstream) : PLGLA (15409 downstream)																																			---	---	---	---
RGPD3	653489	broad.mit.edu	37	2	107052452	107052452	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:107052452delA	uc010ywi.1	-							NM_001144013	NP_001137485			RANBP2-like and GRIP domain containing 3						intracellular transport		binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	107315190	107315190	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:107315190delA								RGPD3 (230389 upstream) : ST6GAL2 (102868 downstream)																																			---	---	---	---
ANAPC1	64682	broad.mit.edu	37	2	112551552	112551552	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112551552delA	uc002thi.2	-							NM_022662	NP_073153			anaphase promoting complex subunit 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2																		---	---	---	---
CKAP2L	150468	broad.mit.edu	37	2	113513316	113513316	+	Intron	DEL	A	-	-	rs150191453		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113513316delA	uc002tie.2	-						CKAP2L_uc002tif.2_Intron|CKAP2L_uc010yxp.1_Intron|CKAP2L_uc010yxq.1_Intron	NM_152515	NP_689728			cytoskeleton associated protein 2-like							centrosome					0																		---	---	---	---
DDX18	8886	broad.mit.edu	37	2	118583908	118583909	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:118583908_118583909insT	uc002tlh.1	+	11	1684_1685	c.1585_1586insT	c.(1585-1587)ATTfs	p.I529fs		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	529	Helicase C-terminal.						ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4																		---	---	---	---
TUBA3D	113457	broad.mit.edu	37	2	132238484	132238484	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132238484delT	uc002tsu.3	+							NM_080386	NP_525125			tubulin, alpha 3d						'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)														---	---	---	---
RND3	390	broad.mit.edu	37	2	151343675	151343678	+	Intron	DEL	TTTT	-	-	rs73967183		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:151343675_151343678delTTTT	uc002txe.2	-						RND3_uc002txf.2_Intron|RND3_uc002txg.2_Intron|RND3_uc010zbv.1_Intron|RND3_uc010zbw.1_5'Flank	NM_005168	NP_005159			ras homolog gene family, member E precursor						actin cytoskeleton organization|cell adhesion|small GTPase mediated signal transduction	Golgi membrane	GTP binding|GTPase activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.106)														---	---	---	---
CACNB4	785	broad.mit.edu	37	2	152695482	152695483	+	3'UTR	DEL	TT	-	-	rs111950042		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152695482_152695483delTT	uc002tya.2	-	14					CACNB4_uc002txy.2_3'UTR|CACNB4_uc002txz.2_3'UTR|CACNB4_uc010fnz.2_3'UTR	NM_000726	NP_000717			calcium channel, voltage-dependent, beta 4						axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)													---	---	---	---
TANC1	85461	broad.mit.edu	37	2	160006760	160006760	+	Intron	DEL	T	-	-	rs111498713		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160006760delT	uc002uag.2	+						TANC1_uc010fol.1_Intron|TANC1_uc010zcm.1_Intron|TANC1_uc010fom.1_Intron|TANC1_uc002uah.1_3'UTR	NM_033394	NP_203752			tetratricopeptide repeat, ankyrin repeat and							cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
BAZ2B	29994	broad.mit.edu	37	2	160231430	160231430	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160231430delA	uc002uao.2	-						BAZ2B_uc002uap.2_Intron	NM_013450	NP_038478			bromodomain adjacent to zinc finger domain, 2B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4																		---	---	---	---
ITGB6	3694	broad.mit.edu	37	2	160968845	160968845	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160968845delT	uc002ubh.2	-						ITGB6_uc010fou.2_Intron|ITGB6_uc010zcq.1_Intron|ITGB6_uc010fov.1_Intron	NM_000888	NP_000879			integrin, beta 6 precursor						cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
PSMD14	10213	broad.mit.edu	37	2	162251500	162251502	+	Intron	DEL	TTT	-	-	rs112832377		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162251500_162251502delTTT	uc002ubu.2	+							NM_005805	NP_005796			proteasome 26S subunit, non-ATPase 14						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K63-linked deubiquitination|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	endopeptidase activator activity|metal ion binding|metallopeptidase activity|proteasome binding|ubiquitin thiolesterase activity			breast(1)	1																		---	---	---	---
TBR1	10716	broad.mit.edu	37	2	162272776	162272776	+	5'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162272776delA	uc002ubw.1	+	1					TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584			T-box, brain, 1							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
AGPS	8540	broad.mit.edu	37	2	178357853	178357853	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178357853delT	uc002ull.2	+						AGPS_uc010zfb.1_Intron	NM_003659	NP_003650			alkyldihydroxyacetone phosphate synthase						ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)															---	---	---	---
TTC30B	150737	broad.mit.edu	37	2	178415367	178415367	+	3'UTR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178415367delT	uc002uln.2	-	1					TTC30B_uc010zfc.1_3'UTR	NM_152517	NP_689730			tetratricopeptide repeat domain 30B						cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)															---	---	---	---
OSBPL6	114880	broad.mit.edu	37	2	179258982	179258982	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179258982delT	uc002ulx.2	+						OSBPL6_uc002uly.2_Intron|OSBPL6_uc010zfe.1_Intron|OSBPL6_uc002ulz.2_Intron|OSBPL6_uc002uma.2_Intron	NM_032523	NP_115912			oxysterol-binding protein-like protein 6 isoform						lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)															---	---	---	---
WDR75	84128	broad.mit.edu	37	2	190323462	190323462	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:190323462delT	uc002uql.1	+						WDR75_uc002uqm.1_Intron|WDR75_uc002uqn.1_Intron|WDR75_uc002uqo.1_Intron	NM_032168	NP_115544			WD repeat domain 75							nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)															---	---	---	---
HSPD1	3329	broad.mit.edu	37	2	198360213	198360215	+	Intron	DEL	ATT	-	-	rs13432424		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198360213_198360215delATT	uc002uui.2	-						HSPD1_uc002uuj.2_Intron|HSPD1_uc010zgx.1_Intron|HSPD1_uc010fsm.2_5'UTR|HSPD1_uc002uuk.2_Intron	NM_002156	NP_002147			chaperonin						'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)															---	---	---	---
CDK15	65061	broad.mit.edu	37	2	202711958	202711958	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202711958delT	uc002uyt.2	+						CDK15_uc010ftm.2_Intron|CDK15_uc002uys.2_Intron|CDK15_uc010ftn.1_Intron|CDK15_uc010fto.1_Intron	NM_139158	NP_631897			PFTAIRE protein kinase 2								ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)													---	---	---	---
IDH1	3417	broad.mit.edu	37	2	209115978	209115979	+	Intron	INS	-	T	T	rs150562455	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:209115978_209115979insT	uc002vcs.2	-						IDH1_uc002vct.2_Intron|IDH1_uc002vcu.2_Intron	NM_005896	NP_005887			isocitrate dehydrogenase 1 (NADP+), soluble						2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)				Mis		gliobastoma 								---	---	---	---
VIL1	7429	broad.mit.edu	37	2	219299818	219299819	+	Intron	DEL	CT	-	-	rs67794207		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219299818_219299819delCT	uc002via.2	+						VIL1_uc010zke.1_Intron|VIL1_uc002vib.2_Intron	NM_007127	NP_009058			villin 1						actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
ACSL3	2181	broad.mit.edu	37	2	223773360	223773360	+	Intron	DEL	A	-	-	rs80016908		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223773360delA	uc002vni.2	+						ACSL3_uc002vnj.2_Intron	NM_004457	NP_004448			acyl-CoA synthetase long-chain family member 3						long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			ovary(2)	2		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)			T	ETV1	prostate								---	---	---	---
SLC16A14	151473	broad.mit.edu	37	2	230902402	230902403	+	Intron	INS	-	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230902402_230902403insT	uc002vqd.1	-						FBXO36_uc010fxi.1_Intron	NM_152527	NP_689740			solute carrier family 16 (monocarboxylic acid							integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)														---	---	---	---
ILKAP	80895	broad.mit.edu	37	2	239079723	239079723	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239079723delA	uc002vxv.2	-						ILKAP_uc010zns.1_Intron|ILKAP_uc002vxw.2_Intron	NM_030768	NP_110395			integrin-linked kinase-associated protein							cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			ovary(3)	3		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)														---	---	---	---
SNED1	25992	broad.mit.edu	37	2	241992218	241992218	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241992218delG	uc002wah.1	+							NM_001080437	NP_001073906			6720455I24Rik homolog precursor						cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)														---	---	---	---
SUMF1	285362	broad.mit.edu	37	3	4452827	4452827	+	Intron	DEL	T	-	-	rs72240947		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:4452827delT	uc003bpz.1	-						SUMF1_uc003bps.1_Intron|SUMF1_uc011ass.1_Intron|SUMF1_uc010hby.1_Intron|SUMF1_uc011ast.1_Intron	NM_182760	NP_877437			sulfatase modifying factor 1 isoform 1							endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			upper_aerodigestive_tract(1)	1		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)														---	---	---	---
GRM7	2917	broad.mit.edu	37	3	7456626	7456626	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:7456626delA	uc003bqm.2	+						GRM7_uc011ata.1_Intron|GRM7_uc011atb.1_Intron|GRM7_uc010hcf.2_Intron|GRM7_uc011atc.1_Intron|GRM7_uc010hcg.2_Intron|GRM7_uc003bql.2_Intron|GRM7_uc003bqn.1_Intron	NM_000844	NP_000835			glutamate receptor, metabotropic 7 isoform a						negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)													---	---	---	---
OGG1	4968	broad.mit.edu	37	3	9797996	9797996	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9797996delA	uc003bsi.2	+						OGG1_uc003bsh.2_Intron|OGG1_uc003bsj.2_Intron|OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|OGG1_uc003bsp.1_Intron|OGG1_uc010hcm.1_Intron|OGG1_uc003bsq.1_Intron|OGG1_uc003bsr.1_Intron	NM_002542	NP_002533			8-oxoguanine DNA-glycosylase 1 isoform 1a						depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)												BER_DNA_glycosylases					---	---	---	---
TTLL3	26140	broad.mit.edu	37	3	9842116	9842117	+	Intron	INS	-	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9842116_9842117insT	uc003btd.3	+						ARPC4_uc003bsz.1_Intron|ARPC4_uc003bta.1_Intron|ARPC4_uc003btb.1_Intron|ARPC4_uc003btc.1_Intron					RecName: Full=Tubulin--tyrosine ligase-like protein 3; AltName: Full=HOTTL;						axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)																	---	---	---	---
VHL	7428	broad.mit.edu	37	3	10182937	10182937	+	5'Flank	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10182937delA	uc003bvc.2	+						VHL_uc003bvd.2_5'Flank	NM_000551	NP_000542			von Hippel-Lindau tumor suppressor isoform 1						anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding			kidney(1273)|soft_tissue(24)|adrenal_gland(15)|large_intestine(13)|pancreas(5)|endometrium(4)|thyroid(3)|upper_aerodigestive_tract(3)|central_nervous_system(2)|lung(2)|pleura(1)|paratesticular_tissues(1)	1346				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)			1	D|Mis|N|F|S		renal|hemangioma|pheochromocytoma	renal|hemangioma|pheochromocytoma			von_Hippel-Lindau_disease|Chuvash_Polycythemia_|Pheochromocytoma_(Adrenal)_Familial				---	---	---	---
TMEM40	55287	broad.mit.edu	37	3	12791467	12791467	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12791467delA	uc003bxg.1	-						TMEM40_uc003bxh.1_Intron|TMEM40_uc003bxi.1_Intron|TMEM40_uc011auv.1_Intron	NM_018306	NP_060776			transmembrane protein 40							integral to membrane					0																		---	---	---	---
IQSEC1	9922	broad.mit.edu	37	3	13094263	13094264	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:13094263_13094264delTT	uc011auw.1	-							NM_001134382	NP_001127854			IQ motif and Sec7 domain 1 isoform a						regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
RAB5A	5868	broad.mit.edu	37	3	20020023	20020024	+	Intron	DEL	GA	-	-	rs139684735	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:20020023_20020024delGA	uc003cbn.2	+						RAB5A_uc010hey.2_Intron|RAB5A_uc011awg.1_Intron	NM_004162	NP_004153			RAB5A, member RAS oncogene family						blood coagulation|protein transport|receptor internalization|regulation of filopodium assembly|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GDP binding|GTP binding|GTPase activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	32676649	32676649	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32676649delT								DYNC1LI1 (64299 upstream) : CNOT10 (50049 downstream)																																			---	---	---	---
CNOT10	25904	broad.mit.edu	37	3	32758896	32758896	+	Intron	DEL	T	-	-	rs75168073		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32758896delT	uc003cfc.1	+						CNOT10_uc011axi.1_Intron|CNOT10_uc003cfd.1_Intron|CNOT10_uc003cfe.1_Intron|CNOT10_uc010hfv.1_Intron|CNOT10_uc011axj.1_Intron|CNOT10_uc010hfw.1_Intron	NM_015442	NP_056257			CCR4-NOT transcription complex, subunit 10						nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
PDCD6IP	10015	broad.mit.edu	37	3	33877438	33877438	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33877438delT	uc003cfx.2	+						PDCD6IP_uc003cfy.2_Intron|PDCD6IP_uc011axw.1_Intron	NM_013374	NP_037506			programmed cell death 6 interacting protein						apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	37238346	37238346	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37238346delA								LRRFIP2 (20495 upstream) : GOLGA4 (46392 downstream)																																			---	---	---	---
GOLGA4	2803	broad.mit.edu	37	3	37369641	37369642	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37369641_37369642insA	uc003cgv.2	+						GOLGA4_uc003cgw.2_Intron|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Intron	NM_002078	NP_002069			golgi autoantigen, golgin subfamily a, 4						Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
ULK4	54986	broad.mit.edu	37	3	41795749	41795749	+	Intron	DEL	A	-	-	rs58341418	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:41795749delA	uc003ckv.3	-							NM_017886	NP_060356			unc-51-like kinase 4								ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)														---	---	---	---
KIF15	56992	broad.mit.edu	37	3	44816593	44816593	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44816593delA	uc003cnx.3	+						KIF15_uc010hiq.2_Intron	NM_020242	NP_064627			kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)														---	---	---	---
SMARCC1	6599	broad.mit.edu	37	3	47814193	47814193	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47814193delT	uc003crq.2	-						SMARCC1_uc011bbd.1_Intron	NM_003074	NP_003065			SWI/SNF-related matrix-associated						chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)														---	---	---	---
CCDC36	339834	broad.mit.edu	37	3	49249057	49249057	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49249057delA	uc003cwk.2	+						CCDC36_uc003cwl.3_Intron|CCDC36_uc011bck.1_Intron|CCDC36_uc010hkt.2_Intron	NM_178173	NP_835467			coiled-coil domain containing 36											ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)														---	---	---	---
C3orf62	375341	broad.mit.edu	37	3	49308392	49308392	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49308392delA	uc003cwn.2	-	3					C3orf62_uc003cwm.2_3'UTR	NM_198562	NP_940964			hypothetical protein LOC375341												0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)														---	---	---	---
ASB14	142686	broad.mit.edu	37	3	57310796	57310796	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57310796delT	uc003diq.2	-						ASB14_uc003dip.1_Intron	NM_001142733	NP_001136205			ankyrin repeat and SOCS box-containing 14						intracellular signal transduction						0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)														---	---	---	---
KCTD6	200845	broad.mit.edu	37	3	58487416	58487416	+	3'UTR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58487416delT	uc003dkj.3	+	3					KCTD6_uc003dki.3_3'UTR|KCTD6_uc003dkk.3_3'UTR	NM_001128214	NP_001121686			potassium channel tetramerisation domain							voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)														---	---	---	---
ATXN7	6314	broad.mit.edu	37	3	63974140	63974141	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:63974140_63974141delAA	uc003dlw.3	+						ATXN7_uc003dlv.2_Intron|ATXN7_uc010hnv.2_Intron|ATXN7_uc011bfn.1_Intron	NM_000333	NP_000324			ataxin 7 isoform a						cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	66687519	66687519	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:66687519delA								LRIG1 (136674 upstream) : KBTBD8 (361208 downstream)																																			---	---	---	---
EIF4E3	317649	broad.mit.edu	37	3	71739006	71739006	+	Intron	DEL	A	-	-	rs57050022		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:71739006delA	uc003dov.3	-						EIF4E3_uc011bgc.1_Intron|EIF4E3_uc003dox.2_Intron|EIF4E3_uc011bgd.1_Intron|EIF4E3_uc010hoc.2_Intron	NM_001134651	NP_001128123			eukaryotic translation initiation factor 4E						regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0		Prostate(10;0.0166)		BRCA - Breast invasive adenocarcinoma(55;2.56e-05)|Epithelial(33;2.9e-05)|Lung(16;9.28e-05)|LUSC - Lung squamous cell carcinoma(21;0.00227)														---	---	---	---
ROBO1	6091	broad.mit.edu	37	3	78706182	78706182	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:78706182delA	uc003dqe.2	-						ROBO1_uc003dqb.2_Intron|ROBO1_uc003dqc.2_Intron|ROBO1_uc003dqd.2_Intron|ROBO1_uc010hoh.2_Intron|ROBO1_uc011bgl.1_Intron	NM_002941	NP_002932			roundabout 1 isoform a						activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)														---	---	---	---
TOMM70A	9868	broad.mit.edu	37	3	100087158	100087158	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100087158delT	uc003dtw.2	-							NM_014820	NP_055635			translocase of outer mitochondrial membrane 70						protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1																		---	---	---	---
MORC1	27136	broad.mit.edu	37	3	108818455	108818455	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108818455delT	uc003dxl.2	-						MORC1_uc011bhn.1_Intron	NM_014429	NP_055244			MORC family CW-type zinc finger 1						cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8																		---	---	---	---
SIDT1	54847	broad.mit.edu	37	3	113322172	113322172	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113322172delT	uc003eak.2	+						SIDT1_uc011bif.1_Intron|SIDT1_uc003eaj.1_Intron|SIDT1_uc011big.1_Intron|SIDT1_uc011bih.1_Intron|SIDT1_uc011bii.1_5'Flank	NM_017699	NP_060169			SID1 transmembrane family, member 1 precursor							integral to membrane				ovary(3)|pancreas(1)|skin(1)	5																		---	---	---	---
GSK3B	2932	broad.mit.edu	37	3	119748921	119748921	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119748921delA	uc003edo.2	-						GSK3B_uc003edn.2_Intron	NM_001146156	NP_001139628			glycogen synthase kinase 3 beta isoform 2						axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding			lung(2)	2				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)													---	---	---	---
IQCB1	9657	broad.mit.edu	37	3	121514222	121514222	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121514222delA	uc010hre.1	-						IQCB1_uc003eek.2_Intron|IQCB1_uc010hrf.1_Intron	NM_001023570	NP_001018864			IQ motif containing B1 isoform a						cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)														---	---	---	---
ATP2C1	27032	broad.mit.edu	37	3	130711967	130711968	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130711967_130711968delTT	uc003enl.2	+						ATP2C1_uc011blg.1_Intron|ATP2C1_uc011blh.1_Intron|ATP2C1_uc011bli.1_Intron|ATP2C1_uc003enk.2_Intron|ATP2C1_uc003enm.2_Intron|ATP2C1_uc003enn.2_Intron|ATP2C1_uc003eno.2_Intron|ATP2C1_uc003enp.2_Intron|ATP2C1_uc003enq.2_Intron|ATP2C1_uc003enr.2_Intron|ATP2C1_uc003ens.2_Intron|ATP2C1_uc003ent.2_Intron|ATP2C1_uc003enu.2_Intron	NM_014382	NP_055197			calcium-transporting ATPase 2C1 isoform 1a						actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)									Hailey-Hailey_disease				---	---	---	---
XRN1	54464	broad.mit.edu	37	3	142132842	142132842	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142132842delA	uc003eus.2	-						XRN1_uc010huu.2_5'Flank|XRN1_uc003eut.2_Intron|XRN1_uc003euu.2_Intron|XRN1_uc003euv.1_Intron	NM_019001	NP_061874			5'-3' exoribonuclease 1 isoform a						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3																		---	---	---	---
PLSCR2	57047	broad.mit.edu	37	3	146172071	146172071	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:146172071delT	uc003evv.1	-						PLSCR2_uc003evw.1_Intron	NM_020359	NP_065092			phospholipid scramblase 2						phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0																		---	---	---	---
CP	1356	broad.mit.edu	37	3	148930097	148930097	+	Intron	DEL	A	-	-	rs35529745	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148930097delA	uc003ewy.3	-						CP_uc011bnr.1_Intron|CP_uc003ewx.3_5'Flank|CP_uc003ewz.2_Intron	NM_000096	NP_000087			ceruloplasmin precursor						cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)													---	---	---	---
DHX36	170506	broad.mit.edu	37	3	154010602	154010603	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:154010602_154010603delTT	uc003ezy.3	-						DHX36_uc010hvq.2_Intron|DHX36_uc003ezz.3_Intron	NM_020865	NP_065916			DEAH (Asp-Glu-Ala-His) box polypeptide 36							cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
MFSD1	64747	broad.mit.edu	37	3	158542255	158542255	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:158542255delA	uc003fcl.1	+						MFSD1_uc003fcm.1_Intron|MFSD1_uc003fcn.1_Intron|MFSD1_uc011bow.1_Intron|MFSD1_uc011box.1_Intron	NM_022736	NP_073573			major facilitator superfamily domain containing						transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)															---	---	---	---
GOLIM4	27333	broad.mit.edu	37	3	167765996	167765996	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167765996delA	uc003ffe.2	-						GOLIM4_uc011bpe.1_Intron|GOLIM4_uc011bpf.1_Intron|GOLIM4_uc011bpg.1_Intron	NM_014498	NP_055313			golgi integral membrane protein 4						transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5																		---	---	---	---
SPATA16	83893	broad.mit.edu	37	3	172694862	172694862	+	Intron	DEL	A	-	-	rs74715497		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:172694862delA	uc003fin.3	-							NM_031955	NP_114161			spermatogenesis associated 16						cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)															---	---	---	---
CCDC39	339829	broad.mit.edu	37	3	180372434	180372437	+	Intron	DEL	AAAA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180372434_180372437delAAAA	uc010hxe.2	-						CCDC39_uc003fkn.2_Intron	NM_181426	NP_852091			coiled-coil domain containing 39						axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)															---	---	---	---
DCUN1D1	54165	broad.mit.edu	37	3	182664889	182664890	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:182664889_182664890insA	uc003fld.1	-						DCUN1D1_uc011bqn.1_Intron	NM_020640	NP_065691			RP42 homolog							ubiquitin ligase complex	protein binding			ovary(1)	1	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)															---	---	---	---
YEATS2	55689	broad.mit.edu	37	3	183440065	183440073	+	Intron	DEL	TCTTTTTTT	-	-	rs151175192		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183440065_183440073delTCTTTTTTT	uc003fly.2	+							NM_018023	NP_060493			YEATS domain containing 2						histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)															---	---	---	---
Unknown	0	broad.mit.edu	37	3	183796101	183796101	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183796101delT								HTR3C (17642 upstream) : HTR3E (18751 downstream)																																			---	---	---	---
TMEM207	131920	broad.mit.edu	37	3	190147704	190147705	+	Intron	DEL	AA	-	-	rs67899321		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:190147704_190147705delAA	uc003fsj.2	-							NM_207316	NP_997199			transmembrane protein 207 precursor							integral to membrane					0	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.0176)														---	---	---	---
FGF12	2257	broad.mit.edu	37	3	192078485	192078485	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:192078485delT	uc003fsx.2	-						FGF12_uc003fsy.2_Intron	NM_021032	NP_066360			fibroblast growth factor 12 isoform 1						cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)														---	---	---	---
SDHAP2	727956	broad.mit.edu	37	3	195392917	195392917	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195392917delT	uc003fuw.2	+						SDHAP2_uc003fut.3_Intron|SDHAP2_uc003fuu.3_Intron|SDHAP2_uc011btb.1_Intron|SDHAP2_uc011btc.1_Intron|SDHAP2_uc003fuv.2_Intron					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0																		---	---	---	---
DLG1	1739	broad.mit.edu	37	3	197023514	197023514	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197023514delA	uc003fxo.3	-						DLG1_uc003fxn.3_Intron|DLG1_uc011bue.1_Intron|DLG1_uc010ial.2_Intron|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_Intron|DLG1_uc010iam.1_Intron|uc003fxq.2_5'Flank	NM_001098424	NP_001091894			discs, large homolog 1 isoform 1						actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)														---	---	---	---
IQCG	84223	broad.mit.edu	37	3	197671126	197671128	+	Intron	DEL	TTT	-	-	rs74574846		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197671126_197671128delTTT	uc003fyo.2	-						IQCG_uc003fyp.2_Intron|IQCG_uc003fyq.3_Intron	NM_001134435	NP_001127907			IQ motif containing G												0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)														---	---	---	---
WHSC1	7468	broad.mit.edu	37	4	1940129	1940129	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1940129delT	uc003gdz.3	+						WHSC1_uc003geb.3_Intron|WHSC1_uc003gec.3_Intron|WHSC1_uc003ged.3_Intron|WHSC1_uc003gee.3_Intron|WHSC1_uc003gef.3_Intron|WHSC1_uc003gei.3_5'Flank|WHSC1_uc003gdy.1_Intron|WHSC1_uc010icd.1_Intron|WHSC1_uc003gea.1_Intron|WHSC1_uc010ice.1_Intron|WHSC1_uc003geh.1_Intron	NM_001042424	NP_001035889			Wolf-Hirschhorn syndrome candidate 1 protein						anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)				T	IGH@	MM								---	---	---	---
TBC1D14	57533	broad.mit.edu	37	4	7006800	7006800	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:7006800delT	uc011bwg.1	+						TBC1D14_uc003gjs.3_Intron|TBC1D14_uc010idh.2_Intron|TBC1D14_uc011bwh.1_Intron|TBC1D14_uc003gju.3_Intron	NM_001113361	NP_001106832			TBC1 domain family, member 14 isoform a							intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2																		---	---	---	---
WDR1	9948	broad.mit.edu	37	4	10100788	10100788	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:10100788delG	uc003gmf.2	-						WDR1_uc003gmg.2_Intron	NM_017491	NP_059830			WD repeat-containing protein 1 isoform 1						platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)														---	---	---	---
FBXL5	26234	broad.mit.edu	37	4	15642249	15642249	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15642249delT	uc003goc.1	-						FBXL5_uc010idw.1_Intron|FBXL5_uc003gob.1_Intron|FBXL5_uc010idx.1_Intron|FBXL5_uc003god.1_Intron|FBXL5_uc010idy.1_Intron	NM_012161	NP_036293			F-box and leucine-rich repeat protein 5 isoform						iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity				0																		---	---	---	---
BST1	683	broad.mit.edu	37	4	15717242	15717242	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15717242delT	uc003goh.3	+						BST1_uc003goi.2_Intron	NM_004334	NP_004325			bone marrow stromal cell antigen 1 precursor						humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)	1																		---	---	---	---
WDR19	57728	broad.mit.edu	37	4	39245702	39245702	+	Intron	DEL	A	-	-	rs34311970		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39245702delA	uc003gtv.2	+						WDR19_uc011byi.1_Intron|WDR19_uc003gtw.1_Intron	NM_025132	NP_079408			WD repeat domain 19						cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1																		---	---	---	---
RFC1	5981	broad.mit.edu	37	4	39313233	39313233	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39313233delA	uc003gty.1	-						RFC1_uc003gtx.1_Intron	NM_002913	NP_002904			replication factor C large subunit						DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
KLB	152831	broad.mit.edu	37	4	39449786	39449786	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39449786delA	uc003gua.2	+						KLB_uc011byj.1_Intron	NM_175737	NP_783864			klotho beta						carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1																		---	---	---	---
GUF1	60558	broad.mit.edu	37	4	44682662	44682662	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:44682662delT	uc003gww.3	+						GUF1_uc010ifz.1_Intron	NM_021927	NP_068746			GUF1 GTPase homolog						translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
SPATA18	132671	broad.mit.edu	37	4	52926826	52926826	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52926826delT	uc003gzl.2	+						SPATA18_uc010igl.1_Intron|SPATA18_uc011bzq.1_Intron|SPATA18_uc003gzk.1_Intron	NM_145263	NP_660306			spermatogenesis associated 18 homolog						mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)															---	---	---	---
Unknown	0	broad.mit.edu	37	4	56179421	56179421	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:56179421delT								KDR (187659 upstream) : SRD5A3 (32988 downstream)																																			---	---	---	---
SRP72	6731	broad.mit.edu	37	4	57352462	57352462	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57352462delT	uc003hbv.2	+						SRP72_uc010ihe.2_Intron|SRP72_uc003hbw.1_Intron	NM_006947	NP_008878			signal recognition particle 72kDa						response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			ovary(1)	1	Glioma(25;0.08)|all_neural(26;0.101)																	---	---	---	---
Unknown	0	broad.mit.edu	37	4	69444612	69444612	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69444612delT								YTHDC1 (228788 upstream) : UGT2B15 (67704 downstream)																																			---	---	---	---
AMBN	258	broad.mit.edu	37	4	71465157	71465157	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71465157delA	uc003hfl.2	+							NM_016519	NP_057603			ameloblastin precursor						bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)															---	---	---	---
ADAMTS3	9508	broad.mit.edu	37	4	73174951	73174951	+	Intron	DEL	T	-	-	rs76753805		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73174951delT	uc003hgk.1	-						ADAMTS3_uc003hgl.2_Intron	NM_014243	NP_055058			ADAM metallopeptidase with thrombospondin type 1						collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
MRPL1	65008	broad.mit.edu	37	4	78804332	78804333	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:78804332_78804333delTT	uc003hku.2	+						MRPL1_uc010iji.1_5'Flank	NM_020236	NP_064621			mitochondrial ribosomal protein L1 precursor								RNA binding				0																		---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83740164	83740164	+	3'UTR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83740164delT	uc003hnf.2	-	27					SEC31A_uc003hnd.2_3'UTR|SEC31A_uc003hne.2_3'UTR|SEC31A_uc011ccl.1_3'UTR|SEC31A_uc003hnl.2_3'UTR|SEC31A_uc003hng.2_3'UTR|SEC31A_uc003hnh.2_3'UTR|SEC31A_uc003hni.2_3'UTR|SEC31A_uc003hnj.2_3'UTR|SEC31A_uc011ccm.1_3'UTR|SEC31A_uc011ccn.1_3'UTR|SEC31A_uc003hnk.2_3'UTR|SEC31A_uc003hnm.2_3'UTR	NM_001077207	NP_001070675			SEC31 homolog A isoform 1						COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
FAM13A	10144	broad.mit.edu	37	4	89670709	89670710	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89670709_89670710delTT	uc003hse.1	-						FAM13A_uc003hsa.1_Intron|FAM13A_uc003hsb.1_Intron|FAM13A_uc003hsd.1_Intron|FAM13A_uc003hsc.1_Intron|FAM13A_uc011cdq.1_Intron|FAM13A_uc003hsf.1_Intron|FAM13A_uc003hsg.1_Intron|FAM13A_uc010ikr.1_Intron	NM_014883	NP_055698			family with sequence similarity 13, member A1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2																		---	---	---	---
TBCK	93627	broad.mit.edu	37	4	107037270	107037270	+	Intron	DEL	T	-	-	rs79018134		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:107037270delT	uc010ilv.2	-						TBCK_uc003hyb.2_Intron|TBCK_uc003hye.2_Intron|TBCK_uc003hyc.2_Intron|TBCK_uc003hyd.2_Intron|TBCK_uc003hyf.2_Intron	NM_001163435	NP_001156907			TBC domain-containing protein kinase-like							intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5																		---	---	---	---
RRH	10692	broad.mit.edu	37	4	110756944	110756944	+	Intron	DEL	T	-	-	rs71595523		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110756944delT	uc003hzv.2	+							NM_006583	NP_006574			peropsin						phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114199851	114199851	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114199851delT	uc003ibe.3	+						ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc003ibc.2_Intron|ANK2_uc011cgb.1_Intron	NM_001148	NP_001139			ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)												OREG0016024	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
METTL14	57721	broad.mit.edu	37	4	119621927	119621927	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119621927delA	uc003icf.2	+						METTL14_uc003icg.2_Intron	NM_020961	NP_066012			methyltransferase like 14							nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0																		---	---	---	---
PRDM5	11107	broad.mit.edu	37	4	121742611	121742611	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:121742611delT	uc003idn.2	-						PRDM5_uc003ido.2_Intron|PRDM5_uc010ine.2_Intron|PRDM5_uc010inf.2_Intron	NM_018699	NP_061169			PR domain containing 5						histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123193663	123193663	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123193663delT	uc003ieh.2	+						KIAA1109_uc003iel.1_Intron|KIAA1109_uc003iek.2_Intron	NM_015312	NP_056127			fragile site-associated protein						regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
SPATA5	166378	broad.mit.edu	37	4	123949662	123949662	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123949662delT	uc003iez.3	+							NM_145207	NP_660208			spermatogenesis associated 5						cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0																		---	---	---	---
INPP4B	8821	broad.mit.edu	37	4	143348542	143348542	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:143348542delA	uc003iix.3	-						INPP4B_uc003iiw.3_Intron|INPP4B_uc011chm.1_Intron|INPP4B_uc011cho.1_Intron|INPP4B_uc003iiz.2_RNA	NM_003866	NP_003857			inositol polyphosphate-4-phosphatase, type II,						signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)																	---	---	---	---
DDX60	55601	broad.mit.edu	37	4	169145281	169145281	+	Intron	DEL	T	-	-	rs76603259		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169145281delT	uc003irp.2	-						DDX60_uc003iro.2_Intron	NM_017631	NP_060101			DEAD (Asp-Glu-Ala-Asp) box polypeptide 60								ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183594117	183594117	+	Intron	DEL	A	-	-	rs3749508	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183594117delA	uc003ivd.1	+							NM_001080477	NP_001073946			odz, odd Oz/ten-m homolog 3						signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183657851	183657852	+	Intron	DEL	AC	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183657851_183657852delAC	uc003ivd.1	+						ODZ3_uc003ive.1_Intron	NM_001080477	NP_001073946			odz, odd Oz/ten-m homolog 3						signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
C4orf41	60684	broad.mit.edu	37	4	184585399	184585399	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184585399delT	uc003ivx.2	+						C4orf41_uc003ivw.2_Intron|C4orf41_uc010isc.2_Intron	NM_021942	NP_068761			hypothetical protein LOC60684 isoform a												0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)														---	---	---	---
SNX25	83891	broad.mit.edu	37	4	186283364	186283364	+	Intron	DEL	A	-	-	rs78356496		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186283364delA	uc003ixh.2	+						SNX25_uc010ish.2_Intron|SNX25_uc003ixi.2_Intron	NM_031953	NP_114159			sorting nexin 25						cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)														---	---	---	---
FAM149A	25854	broad.mit.edu	37	4	187075512	187075512	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187075512delG	uc003iyt.3	+						FAM149A_uc011cla.1_Intron|FAM149A_uc010isj.2_Intron|FAM149A_uc010isk.2_Intron|FAM149A_uc003iyu.3_Intron|FAM149A_uc010isl.2_Intron|FAM149A_uc011clb.1_Intron	NM_015398	NP_056213			hypothetical protein LOC25854											breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)														---	---	---	---
MTRR	4552	broad.mit.edu	37	5	7885676	7885677	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:7885676_7885677delTT	uc003jed.2	+						MTRR_uc010itn.1_Intron|MTRR_uc003jee.3_Intron|MTRR_uc003jef.3_Intron|MTRR_uc003jeg.3_Intron|MTRR_uc010ito.2_Intron	NM_024010	NP_076915			methionine synthase reductase isoform 2						methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)													---	---	---	---
DNAH5	1767	broad.mit.edu	37	5	13708059	13708059	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13708059delA	uc003jfd.2	-						DNAH5_uc003jfc.2_Intron	NM_001369	NP_001360			dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---
NPR3	4883	broad.mit.edu	37	5	32786466	32786467	+	3'UTR	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32786466_32786467delTT	uc003jhv.2	+	8					NPR3_uc011cnz.1_3'UTR|NPR3_uc003jhu.2_3'UTR|C5orf23_uc003jhw.1_5'Flank	NM_000908	NP_000899			natriuretic peptide receptor C/guanylate cyclase						osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)													---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	37051862	37051862	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37051862delT	uc003jkl.3	+						NIPBL_uc003jkk.3_Intron|NIPBL_uc003jkn.2_Frame_Shift_Del_p.N5fs	NM_133433	NP_597677			delangin isoform A						brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
NUP155	9631	broad.mit.edu	37	5	37303148	37303148	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37303148delA	uc003jku.1	-						NUP155_uc003jkt.1_Intron|NUP155_uc010iuz.1_Intron	NM_153485	NP_705618			nucleoporin 155kDa isoform 1						carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
NUP155	9631	broad.mit.edu	37	5	37342847	37342847	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37342847delT	uc003jku.1	-						NUP155_uc003jkt.1_Intron|NUP155_uc010iuz.1_Intron	NM_153485	NP_705618			nucleoporin 155kDa isoform 1						carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
WDR70	55100	broad.mit.edu	37	5	37479851	37479851	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37479851delT	uc003jkv.2	+						WDR70_uc010iva.1_Intron	NM_018034	NP_060504			WD repeat domain 70											ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
KIF2A	3796	broad.mit.edu	37	5	61642858	61642858	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:61642858delT	uc003jsy.3	+						KIF2A_uc003jsz.3_Intron|KIF2A_uc010iwp.2_Intron|KIF2A_uc003jsx.3_Intron|KIF2A_uc010iwq.2_5'Flank	NM_004520	NP_004511			kinesin heavy chain member 2 isoform 1						blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding				0		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)														---	---	---	---
SLC30A5	64924	broad.mit.edu	37	5	68399960	68399960	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68399960delT	uc003jvh.2	+						SLC30A5_uc003jvg.2_3'UTR|SLC30A5_uc011crc.1_RNA|SLC30A5_uc003jvi.2_Intron	NM_022902	NP_075053			solute carrier family 30 (zinc transporter),						cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			central_nervous_system(1)	1		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)														---	---	---	---
MCCC2	64087	broad.mit.edu	37	5	70939896	70939899	+	Intron	DEL	GTGC	-	-	rs71859051		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:70939896_70939899delGTGC	uc003kbs.3	+						MCCC2_uc003kbt.3_Intron	NM_022132	NP_071415			methylcrotonoyl-Coenzyme A carboxylase 2 (beta)						leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)													---	---	---	---
COL4A3BP	10087	broad.mit.edu	37	5	74670244	74670244	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:74670244delA	uc011csu.1	-						COL4A3BP_uc003kds.2_Intron|COL4A3BP_uc003kdt.2_Intron	NM_005713	NP_005704			alpha 3 type IV collagen binding protein isoform						ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)														---	---	---	---
SERINC5	256987	broad.mit.edu	37	5	79473234	79473234	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79473234delA	uc003kgj.2	-						SERINC5_uc003kgk.2_Intron|SERINC5_uc003kgl.2_Intron|SERINC5_uc003kgm.2_Intron|SERINC5_uc011ctj.1_Intron	NM_178276	NP_840060			developmentally regulated protein TPO1						phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)														---	---	---	---
CKMT2	1160	broad.mit.edu	37	5	80538123	80538123	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80538123delT	uc003khc.3	+						RNU5E_uc011cto.1_Intron|CKMT2_uc010jaq.2_Intron|CKMT2_uc003khd.3_Intron|uc003khe.1_Intron|uc003khf.1_Intron|uc003khg.1_Intron	NM_001825	NP_001816			sarcomeric mitochondrial creatine kinase						creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)													---	---	---	---
FAM81B	153643	broad.mit.edu	37	5	94776556	94776556	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94776556delA	uc003kla.1	+						FAM81B_uc010jbe.1_Intron	NM_152548	NP_689761			hypothetical protein LOC153643											ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)														---	---	---	---
LNPEP	4012	broad.mit.edu	37	5	96350412	96350412	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:96350412delA	uc003kmv.1	+						LNPEP_uc003kmw.1_Intron	NM_005575	NP_005566			leucyl/cystinyl aminopeptidase isoform 1						cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)														---	---	---	---
COMMD10	51397	broad.mit.edu	37	5	115553612	115553612	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:115553612delA	uc003krt.1	+							NM_016144	NP_057228			COMM domain containing 10								protein binding			ovary(1)	1		all_cancers(142;0.0834)|all_epithelial(76;0.00314)|Prostate(80;0.0102)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;4.3e-07)|Epithelial(69;8.06e-07)|all cancers(49;4.06e-05)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	126847110	126847110	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:126847110delA								MEGF10 (50202 upstream) : PRRC1 (6199 downstream)																																			---	---	---	---
SLC12A2	6558	broad.mit.edu	37	5	127487249	127487249	+	Intron	DEL	T	-	-	rs146057040		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127487249delT	uc003kus.2	+						SLC12A2_uc010jdf.2_Intron|SLC12A2_uc010jdg.2_Intron	NM_001046	NP_001037			solute carrier family 12						potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)													---	---	---	---
SLC12A2	6558	broad.mit.edu	37	5	127497600	127497600	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127497600delT	uc003kus.2	+						SLC12A2_uc010jdf.2_Intron|SLC12A2_uc010jdg.2_Intron|SLC12A2_uc003kut.1_Intron	NM_001046	NP_001037			solute carrier family 12						potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)													---	---	---	---
RAPGEF6	51735	broad.mit.edu	37	5	130764956	130764956	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130764956delA	uc003kvn.1	-						RAPGEF6_uc003kvp.1_Intron|RAPGEF6_uc003kvo.1_Intron|RAPGEF6_uc010jdi.1_Intron|RAPGEF6_uc010jdj.1_Intron|RAPGEF6_uc003kvm.1_Intron	NM_016340	NP_057424			PDZ domain-containing guanine nucleotide						Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)														---	---	---	---
RAPGEF6	51735	broad.mit.edu	37	5	130800138	130800139	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130800138_130800139delTT	uc003kvn.1	-						RAPGEF6_uc003kvp.1_Intron|RAPGEF6_uc003kvo.1_Intron|RAPGEF6_uc010jdi.1_Intron|RAPGEF6_uc010jdj.1_Intron|RAPGEF6_uc003kvq.2_Intron|RAPGEF6_uc003kvr.2_Intron|RAPGEF6_uc011cxe.1_Intron|RAPGEF6_uc010jdk.2_Intron	NM_016340	NP_057424			PDZ domain-containing guanine nucleotide						Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)														---	---	---	---
TXNDC15	79770	broad.mit.edu	37	5	134235522	134235522	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134235522delA	uc003lac.1	+	5					TXNDC15_uc010jdy.1_RNA|TXNDC15_uc011cxv.1_RNA	NM_024715	NP_078991			disulfide isomerase precursor						cell redox homeostasis	integral to membrane				ovary(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
BRD8	10902	broad.mit.edu	37	5	137475948	137475949	+	Intron	INS	-	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137475948_137475949insT	uc003lcf.1	-						BRD8_uc003lcc.1_Intron|NME5_uc003lce.2_5'Flank	NM_139199	NP_631938			bromodomain containing 8 isoform 2						cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
PCDHGA2	56113	broad.mit.edu	37	5	140756244	140756244	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140756244delT	uc003ljk.1	+						PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron	NM_018915	NP_061738			protocadherin gamma subfamily A, 2 isoform 1						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
DCTN4	51164	broad.mit.edu	37	5	150111159	150111159	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150111159delA	uc003lsv.2	-						DCTN4_uc003lsu.2_Intron|DCTN4_uc010jhi.2_Intron|DCTN4_uc010jhj.2_Intron|DCTN4_uc011dck.1_Intron	NM_016221	NP_057305			dynactin 4 (p62) isoform b							centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
C5orf4	10826	broad.mit.edu	37	5	154217841	154217842	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154217841_154217842delAA	uc003lvs.3	-						C5orf4_uc011dde.1_Intron	NM_032385	NP_115761			hypothetical protein LOC10826						fatty acid biosynthetic process	integral to membrane	iron ion binding|oxidoreductase activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
TIMD4	91937	broad.mit.edu	37	5	156381896	156381896	+	Intron	DEL	T	-	-	rs71922795		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156381896delT	uc003lwh.2	-						TIMD4_uc010jii.2_Intron	NM_138379	NP_612388			T-cell immunoglobulin and mucin domain							integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)															---	---	---	---
NUDCD2	134492	broad.mit.edu	37	5	162884225	162884225	+	Intron	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:162884225delC	uc003lze.2	-							NM_145266	NP_660309			NudC domain containing 2							intracellular					0	Renal(175;0.000281)	Medulloblastoma(196;0.0207)|all_neural(177;0.0966)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0981)|OV - Ovarian serous cystadenocarcinoma(192;0.183)|Epithelial(171;0.247)														---	---	---	---
PANK3	79646	broad.mit.edu	37	5	167988163	167988163	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167988163delA	uc003lzz.1	-						uc003maa.1_5'Flank|MIR103-1_hsa-mir-103-1|MI0000109_5'Flank	NM_024594	NP_078870			pantothenate kinase 3						coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)														---	---	---	---
NPM1	4869	broad.mit.edu	37	5	170819655	170819655	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:170819655delT	uc011dex.1	+						NPM1_uc003mbh.2_Intron|NPM1_uc003mbi.2_Intron|NPM1_uc003mbj.2_Intron	NM_002520	NP_002511			nucleophosmin 1 isoform 1						anti-apoptosis|cell aging|CenH3-containing nucleosome assembly at centromere|centrosome cycle|DNA repair|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	histone binding|NF-kappaB binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|RNA binding|Tat protein binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	haematopoietic_and_lymphoid_tissue(3109)|skin(1)	3110	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)					T|F 	ALK|RARA|MLF1	NHL|APL|AML								---	---	---	---
DBN1	1627	broad.mit.edu	37	5	176887764	176887764	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176887764delT	uc003mgy.2	-						DBN1_uc011dga.1_Intron|DBN1_uc003mgx.2_Intron|DBN1_uc010jkn.1_Intron|DBN1_uc003mgz.1_Intron	NM_004395	NP_004386			drebrin 1 isoform a						actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
FLT4	2324	broad.mit.edu	37	5	180049927	180049928	+	Intron	DEL	CA	-	-	rs113248876		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180049927_180049928delCA	uc003mma.3	-						FLT4_uc003mlz.3_Intron|FLT4_uc003mmb.1_Intron|FLT4_uc011dgy.1_Intron	NM_002020	NP_002011			fms-related tyrosine kinase 4 isoform 2						positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)									Congenital_Hereditary_Lymphedema				---	---	---	---
Unknown	0	broad.mit.edu	37	5	180165983	180165983	+	IGR	DEL	G	-	-	rs2054696	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180165983delG								FLT4 (89359 upstream) : OR2Y1 (140 downstream)																																			---	---	---	---
SNRNP48	154007	broad.mit.edu	37	6	7609033	7609033	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7609033delT	uc003mxr.2	+						SNRNP48_uc003mxs.2_Intron	NM_152551	NP_689764			U11/U12 snRNP 48K						mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0																		---	---	---	---
HIST1H2BJ	8970	broad.mit.edu	37	6	27099962	27099963	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27099962_27099963delAA	uc003niu.1	-						HIST1H2AG_uc003niw.2_5'Flank					Homo sapiens histone cluster 1, H2bj, mRNA (cDNA clone IMAGE:4048288), with apparent retained intron.						defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	6	30665317	30665317	+	IGR	DEL	T	-	-	rs137943555		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30665317delT								NRM (6259 upstream) : MDC1 (2268 downstream)																																			---	---	---	---
SYNGAP1	8831	broad.mit.edu	37	6	33408466	33408467	+	Intron	DEL	TC	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33408466_33408467delTC	uc011dri.1	+						SYNGAP1_uc010juy.2_Intron|SYNGAP1_uc010juz.2_Intron	NM_006772	NP_006763			synaptic Ras GTPase activating protein 1						negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4																		---	---	---	---
FTSJD2	23070	broad.mit.edu	37	6	37420622	37420622	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:37420622delT	uc003ons.2	+						FTSJD2_uc010jwu.2_Intron	NM_015050	NP_055865			FtsJ methyltransferase domain containing 2						mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51921383	51921383	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51921383delT	uc003pah.1	-						PKHD1_uc003pai.2_Intron	NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51935416	51935416	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51935416delA	uc003pah.1	-						PKHD1_uc003pai.2_Intron	NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51946932	51946933	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51946932_51946933insA	uc003pah.1	-						PKHD1_uc003pai.2_Intron	NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
GSTA4	2941	broad.mit.edu	37	6	52847151	52847153	+	Intron	DEL	AAA	-	-	rs67398044		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:52847151_52847153delAAA	uc003pbc.2	-						GSTA4_uc003pbd.2_Intron|GSTA4_uc003pbe.2_Intron|GSTA4_uc003pbf.2_Intron	NM_001512	NP_001503			glutathione S-transferase alpha 4						glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity|protein homodimerization activity				0	Lung NSC(77;0.103)				Glutathione(DB00143)													---	---	---	---
PRIM2	5558	broad.mit.edu	37	6	57472237	57472238	+	Intron	INS	-	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:57472237_57472238insT	uc003pdx.2	+							NM_000947	NP_000938			DNA primase polypeptide 2						DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	66804527	66804527	+	IGR	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:66804527delG								MCART3P (305152 upstream) : None (None downstream)																																			---	---	---	---
BAI3	577	broad.mit.edu	37	6	69724186	69724187	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:69724186_69724187insA	uc003pev.3	+						BAI3_uc010kak.2_Intron	NM_001704	NP_001695			brain-specific angiogenesis inhibitor 3						negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)																---	---	---	---
BAI3	577	broad.mit.edu	37	6	70049069	70049070	+	Intron	DEL	AA	-	-	rs3737019	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70049069_70049070delAA	uc003pev.3	+						BAI3_uc010kak.2_Intron|BAI3_uc011dxx.1_Intron|BAI3_uc003pex.1_Intron	NM_001704	NP_001695			brain-specific angiogenesis inhibitor 3						negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)																---	---	---	---
COL19A1	1310	broad.mit.edu	37	6	70609058	70609061	+	Intron	DEL	TTTT	-	-	rs112888229		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70609058_70609061delTTTT	uc003pfc.1	+							NM_001858	NP_001849			alpha 1 type XIX collagen precursor						cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4																		---	---	---	---
SMAP1	60682	broad.mit.edu	37	6	71508370	71508370	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:71508370delA	uc003pfr.2	+	6	754	c.506delA	c.(505-507)GAAfs	p.E169fs	SMAP1_uc011dxy.1_RNA|SMAP1_uc003pfs.2_Frame_Shift_Del_p.E142fs|SMAP1_uc010kao.2_Frame_Shift_Del_p.E142fs|SMAP1_uc010kap.2_Frame_Shift_Del_p.E159fs	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	stromal membrane-associated GTPase-activating	169					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding				0																		---	---	---	---
RIMS1	22999	broad.mit.edu	37	6	72952000	72952000	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:72952000delT	uc003pga.2	+						RIMS1_uc011dyb.1_Intron|RIMS1_uc003pgc.2_Intron|RIMS1_uc010kaq.2_Intron|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Intron|RIMS1_uc011dyd.1_Intron|RIMS1_uc003pgb.3_Intron|RIMS1_uc010kas.1_Intron	NM_014989	NP_055804			regulating synaptic membrane exocytosis 1						calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)																---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75855328	75855331	+	Intron	DEL	TTTT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75855328_75855331delTTTT	uc003phs.2	-						COL12A1_uc003pht.2_Intron	NM_004370	NP_004361			collagen, type XII, alpha 1 long isoform						cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
NT5E	4907	broad.mit.edu	37	6	86200696	86200696	+	Intron	DEL	T	-	-	rs78785302		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:86200696delT	uc003pko.3	+						NT5E_uc010kbr.2_Intron	NM_002526	NP_002517			5' nucleotidase, ecto precursor						DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)													---	---	---	---
RARS2	57038	broad.mit.edu	37	6	88228194	88228194	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88228194delT	uc003pme.2	-						RARS2_uc003pmb.2_Intron|RARS2_uc003pmc.2_Intron|RARS2_uc003pmd.2_Intron|RARS2_uc003pmf.2_Intron	NM_020320	NP_064716			arginyl-tRNA synthetase 2, mitochondrial						arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)														---	---	---	---
RARS2	57038	broad.mit.edu	37	6	88240359	88240359	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88240359delA	uc003pme.2	-						RARS2_uc003pmb.2_Intron|RARS2_uc003pmc.2_Intron|RARS2_uc003pmd.2_Intron|RARS2_uc003pmf.2_Intron	NM_020320	NP_064716			arginyl-tRNA synthetase 2, mitochondrial						arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)														---	---	---	---
MDN1	23195	broad.mit.edu	37	6	90489788	90489789	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90489788_90489789delAA	uc003pnn.1	-						MDN1_uc003pno.1_Intron	NM_014611	NP_055426			MDN1, midasin homolog						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)														---	---	---	---
FHL5	9457	broad.mit.edu	37	6	97051249	97051249	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97051249delT	uc003pos.1	+						FHL5_uc003pot.1_Intron	NM_020482	NP_065228			activator of cAMP-responsive element modulator							nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)														---	---	---	---
GPR63	81491	broad.mit.edu	37	6	97246258	97246258	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97246258delA	uc010kcl.2	-	3					GPR63_uc003pou.2_3'UTR	NM_001143957	NP_001137429			G protein-coupled receptor 63							integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)														---	---	---	---
C6orf167	253714	broad.mit.edu	37	6	97715988	97715988	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97715988delT	uc003ppb.2	-						C6orf167_uc011eaf.1_Intron|C6orf167_uc010kcn.1_Intron|C6orf167_uc010kco.1_Intron|C6orf167_uc003ppc.2_Intron	NM_198468	NP_940870			hypothetical protein LOC253714						double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)														---	---	---	---
GRIK2	2898	broad.mit.edu	37	6	102503058	102503058	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:102503058delT	uc003pqp.3	+						GRIK2_uc003pqo.3_Intron|GRIK2_uc010kcw.2_Intron	NM_021956	NP_068775			glutamate receptor, ionotropic, kainate 2						glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)													---	---	---	---
PREP	5550	broad.mit.edu	37	6	105725779	105725779	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:105725779delA	uc003prc.2	-	15						NM_002726	NP_002717			prolyl endopeptidase						proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)													---	---	---	---
KPNA5	3841	broad.mit.edu	37	6	117026119	117026119	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117026119delT	uc003pxh.2	+							NM_002269	NP_002260			karyopherin alpha 5						NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)														---	---	---	---
DCBLD1	285761	broad.mit.edu	37	6	117864560	117864560	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117864560delT	uc003pxs.2	+						GOPC_uc003pxq.1_Intron|DCBLD1_uc003pxr.1_Intron|DCBLD1_uc003pxt.1_Intron	NM_173674	NP_775945			discoidin, CUB and LCCL domain containing 1						cell adhesion	integral to membrane				ovary(1)	1		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)														---	---	---	---
PTPRK	5796	broad.mit.edu	37	6	128312196	128312196	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:128312196delA	uc003qbk.2	-						PTPRK_uc003qbj.2_Intron|PTPRK_uc010kfc.2_Intron|PTPRK_uc011ebu.1_Intron	NM_002844	NP_002835			protein tyrosine phosphatase, receptor type, K						cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129475559	129475559	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129475559delA	uc003qbn.2	+						LAMA2_uc003qbo.2_Intron	NM_000426	NP_000417			laminin alpha 2 subunit isoform a precursor						cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
EPB41L2	2037	broad.mit.edu	37	6	131276121	131276121	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131276121delT	uc003qch.2	-						EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Intron|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Intron	NM_001431	NP_001422			erythrocyte membrane protein band 4.1-like 2						cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)														---	---	---	---
ALDH8A1	64577	broad.mit.edu	37	6	135265198	135265199	+	Intron	INS	-	TTTTG	TTTTG	rs146661388	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:135265198_135265199insTTTTG	uc003qew.2	-						ALDH8A1_uc003qex.2_Intron|ALDH8A1_uc010kgh.2_Intron|ALDH8A1_uc011ecx.1_Intron	NM_022568	NP_072090			aldehyde dehydrogenase 8A1 isoform 1						retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	145029205	145029206	+	Intron	INS	-	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:145029205_145029206insT	uc003qkt.2	+							NM_007124	NP_009055			utrophin						muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	145124398	145124398	+	Intron	DEL	T	-	-	rs71673559		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:145124398delT	uc003qkt.2	+							NM_007124	NP_009055			utrophin						muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
CNKSR3	154043	broad.mit.edu	37	6	154762303	154762303	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:154762303delA	uc003qpy.2	-							NM_173515	NP_775786			CNKSR family member 3						negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)														---	---	---	---
TFB1M	51106	broad.mit.edu	37	6	155618368	155618368	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155618368delT	uc003qqj.3	-						TFB1M_uc003qqk.2_Intron	NM_016020	NP_057104			transcription factor B1, mitochondrial						regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			skin(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)														---	---	---	---
SYNJ2	8871	broad.mit.edu	37	6	158502667	158502668	+	Intron	DEL	TC	-	-	rs149018292	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158502667_158502668delTC	uc003qqx.1	+						SYNJ2_uc003qqw.1_Intron|SYNJ2_uc003qqy.1_Intron|SYNJ2_uc003qqz.1_Intron|SYNJ2_uc003qra.1_Intron	NM_003898	NP_003889			synaptojanin 2								nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)														---	---	---	---
TCP10L2	401285	broad.mit.edu	37	6	167595502	167595502	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:167595502delA	uc010kkp.2	+	8						NM_001145121	NP_001138593			t-complex 10-like 2												0																		---	---	---	---
C6orf70	55780	broad.mit.edu	37	6	170181412	170181412	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:170181412delT	uc003qxg.1	+						C6orf70_uc011ehb.1_Intron|C6orf70_uc003qxh.1_Intron|C6orf70_uc010kky.1_Intron|C6orf70_uc003qxi.1_Intron	NM_018341	NP_060811			hypothetical protein LOC55780							integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)														---	---	---	---
Unknown	0	broad.mit.edu	37	7	2433788	2433788	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2433788delT								EIF3B (13413 upstream) : CHST12 (9435 downstream)																																			---	---	---	---
GNA12	2768	broad.mit.edu	37	7	2793374	2793374	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2793374delT	uc003smu.2	-						GNA12_uc011jwb.1_Intron|GNA12_uc003smt.2_Intron	NM_007353	NP_031379			guanine nucleotide binding protein (G protein)						G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.02e-13)														---	---	---	---
THSD7A	221981	broad.mit.edu	37	7	11452108	11452108	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:11452108delA	uc003ssf.3	-							NM_015204	NP_056019			thrombospondin, type I, domain containing 7A							integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)											HNSCC(18;0.044)			---	---	---	---
ABCB5	340273	broad.mit.edu	37	7	20739337	20739338	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:20739337_20739338delAA	uc003suw.3	+						ABCB5_uc010kuh.2_Intron	NM_178559	NP_848654			ATP-binding cassette, sub-family B, member 5						regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6																		---	---	---	---
CHN2	1124	broad.mit.edu	37	7	29438232	29438232	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:29438232delG	uc003szz.2	+						CHN2_uc011jzs.1_Intron|CHN2_uc010kva.2_Intron|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Intron|CHN2_uc011jzt.1_Intron|CHN2_uc010kvd.2_Intron|CHN2_uc011jzu.1_Intron	NM_004067	NP_004058			beta chimerin isoform 2						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2																		---	---	---	---
PLEKHA8	84725	broad.mit.edu	37	7	30113605	30113607	+	Intron	DEL	AAA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30113605_30113607delAAA	uc003tam.1	+						PLEKHA8_uc003tao.2_Intron|PLEKHA8_uc003tap.1_Intron|PLEKHA8_uc003tan.2_Intron	NM_032639	NP_116028			pleckstrin homology domain containing, family A						protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4																		---	---	---	---
AVL9	23080	broad.mit.edu	37	7	32763379	32763380	+	Intron	INS	-	TGTG	TGTG			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32763379_32763380insTGTG	uc011kai.1	+							NM_015060	NP_055875			AVL9 homolog (S. cerevisiase)							integral to membrane					0																		---	---	---	---
POU6F2	11281	broad.mit.edu	37	7	39125707	39125707	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:39125707delT	uc003thb.1	+						POU6F2_uc010kxo.2_Intron	NM_007252	NP_009183			POU class 6 homeobox 2 isoform 1						central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1																		---	---	---	---
POU6F2	11281	broad.mit.edu	37	7	39246850	39246850	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:39246850delT	uc003thb.1	+						POU6F2_uc010kxo.2_Intron	NM_007252	NP_009183			POU class 6 homeobox 2 isoform 1						central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1																		---	---	---	---
C7orf57	136288	broad.mit.edu	37	7	48086205	48086205	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48086205delA	uc003toh.3	+	5	711	c.499delA	c.(499-501)AAAfs	p.K167fs	C7orf57_uc003toi.3_Frame_Shift_Del_p.K41fs	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	167										ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	56635559	56635559	+	IGR	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:56635559delG								DKFZp434L192 (70582 upstream) : ZNF479 (551769 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	7	64528814	64528815	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:64528814_64528815delTT	uc003ttt.1	+						uc010kzt.1_Intron|uc003ttu.1_5'Flank					Homo sapiens cDNA clone IMAGE:4215179, partial cds.																														---	---	---	---
Unknown	0	broad.mit.edu	37	7	65222951	65222951	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65222951delT	uc003tud.1	-						CCT6P1_uc003tug.2_Intron|CCT6P1_uc003tuh.2_Intron|CCT6P1_uc003tui.2_Intron|uc003tuk.1_5'Flank					Homo sapiens hypothetical LOC441242, mRNA (cDNA clone MGC:87648 IMAGE:5267764), complete cds.																														---	---	---	---
Unknown	0	broad.mit.edu	37	7	65246448	65246448	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65246448delT								CCT6P1 (17787 upstream) : VKORC1L1 (91809 downstream)																																			---	---	---	---
C7orf42	55069	broad.mit.edu	37	7	66418600	66418600	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66418600delT	uc003tvk.2	+						C7orf42_uc010lah.2_Intron|C7orf42_uc003tvl.2_Intron	NM_017994	NP_060464			hypothetical protein LOC55069							integral to membrane				ovary(1)	1																		---	---	---	---
PMS2L11	441263	broad.mit.edu	37	7	76657314	76657314	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:76657314delA	uc011kgn.1	+											Homo sapiens cDNA FLJ59034 complete cds, moderately similar to Protein deltex-2.												0																		---	---	---	---
SEMA3E	9723	broad.mit.edu	37	7	83025865	83025865	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:83025865delA	uc003uhy.1	-							NM_012431	NP_036563			semaphorin 3E precursor						axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)																---	---	---	---
DBF4	10926	broad.mit.edu	37	7	87525649	87525649	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87525649delT	uc003ujf.1	+						DBF4_uc003ujh.1_Intron|DBF4_uc003ujg.1_Intron|DBF4_uc011khf.1_Intron	NM_006716	NP_006707			activator of S phase kinase						cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)																---	---	---	---
ADAM22	53616	broad.mit.edu	37	7	87778496	87778496	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87778496delT	uc003ujn.2	+						ADAM22_uc003ujk.1_Intron|ADAM22_uc003ujl.1_Intron|ADAM22_uc003ujm.2_Intron|ADAM22_uc003ujo.2_Intron|ADAM22_uc003ujp.1_Intron	NM_021723	NP_068369			ADAM metallopeptidase domain 22 isoform 1						cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
SGCE	8910	broad.mit.edu	37	7	94227891	94227891	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94227891delA	uc003unl.2	-						SGCE_uc003unk.2_Intron|SGCE_uc003unm.2_Intron|SGCE_uc003unn.2_Intron|SGCE_uc011kic.1_Intron|SGCE_uc011kid.1_Intron	NM_003919	NP_003910			sarcoglycan, epsilon isoform 2						cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)															---	---	---	---
ARPC1B	10095	broad.mit.edu	37	7	98988326	98988329	+	Intron	DEL	TTTT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98988326_98988329delTTTT	uc003upz.2	+						ARPC1B_uc003uqa.2_Intron|ARPC1B_uc003uqb.2_Intron|ARPC1B_uc003uqc.2_Intron|ARPC1B_uc003uqd.2_5'Flank	NM_005720	NP_005711			actin related protein 2/3 complex subunit 1B						cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
ZSCAN21	7589	broad.mit.edu	37	7	99661217	99661218	+	Intron	INS	-	A	A	rs138796923		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99661217_99661218insA	uc003uso.2	+						ZSCAN21_uc003usn.1_Intron	NM_145914	NP_666019			zinc finger protein 38						positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)															---	---	---	---
TAF6	6878	broad.mit.edu	37	7	99710906	99710906	+	Intron	DEL	A	-	-	rs75828513		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99710906delA	uc003uti.2	-						TAF6_uc003utg.2_Intron|TAF6_uc003uth.2_Intron|TAF6_uc003utk.2_Intron|TAF6_uc011kji.1_Intron|TAF6_uc003utj.2_Intron|TAF6_uc003utl.2_Intron|TAF6_uc003utm.2_Intron|TAF6_uc003utn.1_Intron	NM_139315	NP_647476			TBP-associated factor 6 isoform alpha						negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
PVRIG	79037	broad.mit.edu	37	7	99817848	99817848	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99817848delG	uc003uue.2	+	4	602	c.230delG	c.(229-231)TGGfs	p.W77fs	GATS_uc003uty.3_Intron|GATS_uc003utz.3_Intron|GATS_uc003uua.3_Intron|GATS_uc010lgt.2_Intron|GATS_uc011kjl.1_Intron|GATS_uc010lgu.2_Intron|PVRIG_uc003uuf.1_Frame_Shift_Del_p.W77fs	NM_024070	NP_076975	Q6DKI7	PVRIG_HUMAN	poliovirus receptor related immunoglobulin	77	Helical; (Potential).					integral to membrane				skin(2)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
CUX1	1523	broad.mit.edu	37	7	101839857	101839857	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:101839857delT	uc003uyx.3	+						CUX1_uc003uys.3_Intron|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530			cut-like homeobox 1 isoform a						negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
PUS7	54517	broad.mit.edu	37	7	105102889	105102889	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105102889delA	uc003vcx.2	-						PUS7_uc010lji.2_Intron|PUS7_uc003vcy.2_Intron|PUS7_uc003vcz.1_Intron	NM_019042	NP_061915			pseudouridylate synthase 7 homolog						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1																		---	---	---	---
ATXN7L1	222255	broad.mit.edu	37	7	105516750	105516750	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105516750delT	uc003vde.2	-						ATXN7L1_uc003vdi.2_Intron|CDHR3_uc003vdk.2_5'Flank|uc003vdj.1_5'Flank	NM_020725	NP_065776			ataxin 7-like 1 isoform 1												0																		---	---	---	---
LAMB4	22798	broad.mit.edu	37	7	107749452	107749452	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107749452delT	uc010ljo.1	-						LAMB4_uc003vey.2_Intron	NM_007356	NP_031382			laminin, beta 4 precursor						cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8																		---	---	---	---
CADPS2	93664	broad.mit.edu	37	7	122337666	122337666	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122337666delA	uc010lkp.2	-						CADPS2_uc010lkq.2_Intron	NM_017954	NP_060424			Ca2+-dependent activator protein for secretion 2						exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
MKLN1	4289	broad.mit.edu	37	7	131130352	131130365	+	Intron	DEL	TAGAGATCCCCTTT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:131130352_131130365delTAGAGATCCCCTTT	uc011kpm.1	+						MKLN1_uc011kpl.1_Intron|MKLN1_uc010lmh.2_Intron|MKLN1_uc003vqs.2_Intron	NM_013255	NP_037387			muskelin 1, intracellular mediator containing						signal transduction	cytoplasm	protein binding			breast(1)	1	Melanoma(18;0.162)																	---	---	---	---
AKR1B15	441282	broad.mit.edu	37	7	134252866	134252866	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:134252866delA	uc011kpr.1	+						AKR1B15_uc003vrt.2_Intron|AKR1B15_uc011kps.1_Intron	NM_001080538	NP_001074007			aldo-keto reductase family 1, member B15								oxidoreductase activity			ovary(1)	1																		---	---	---	---
TRIM24	8805	broad.mit.edu	37	7	138269422	138269423	+	Intron	DEL	AT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138269422_138269423delAT	uc003vuc.2	+						TRIM24_uc003vub.2_Intron	NM_015905	NP_056989			transcriptional intermediary factor 1 alpha						cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8																		---	---	---	---
NDUFB2	4708	broad.mit.edu	37	7	140404902	140404905	+	Intron	DEL	TTTT	-	-	rs72099907		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140404902_140404905delTTTT	uc003vwa.2	+						NDUFB2_uc010lnl.2_Intron	NM_004546	NP_004537			NADH dehydrogenase (ubiquinone) 1 beta						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.00956)				NADH(DB00157)													---	---	---	---
SMARCD3	6604	broad.mit.edu	37	7	150945713	150945713	+	5'UTR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150945713delT	uc003wjs.2	-	1					SMARCD3_uc003wjt.2_Intron|SMARCD3_uc003wju.2_Intron|SMARCD3_uc011kvh.1_5'UTR|SMARCD3_uc010lqa.1_5'UTR	NM_001003801	NP_001003801			SWI/SNF related, matrix associated, actin						cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151864134	151864134	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151864134delA	uc003wla.2	-						MLL3_uc003wkz.2_Intron|MLL3_uc003wky.2_Intron	NM_170606	NP_733751			myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
ACTR3B	57180	broad.mit.edu	37	7	152498544	152498544	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:152498544delT	uc003wle.1	+						ACTR3B_uc003wlf.1_Intron|ACTR3B_uc003wlg.1_Intron|ACTR3B_uc011kvp.1_Intron	NM_020445	NP_065178			actin-related protein 3-beta isoform 1						regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding				0		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)														---	---	---	---
Unknown	0	broad.mit.edu	37	8	12560720	12560720	+	IGR	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:12560720delG								FAM66D (136366 upstream) : LONRF1 (18686 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	8	17891350	17891350	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17891350delA								PCM1 (3895 upstream) : ASAH1 (22575 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	8	18228677	18228677	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:18228677delA								NAT1 (147480 upstream) : NAT2 (20078 downstream)																																			---	---	---	---
PIWIL2	55124	broad.mit.edu	37	8	22173618	22173618	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22173618delT	uc003xbn.2	+						PIWIL2_uc011kzf.1_Intron|PIWIL2_uc010ltv.2_Intron	NM_018068	NP_060538			piwi-like 2						DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)														---	---	---	---
SLC39A14	23516	broad.mit.edu	37	8	22273947	22273947	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22273947delT	uc003xbq.3	+						SLC39A14_uc011kzg.1_Intron|SLC39A14_uc003xbp.3_Intron|SLC39A14_uc011kzh.1_Intron	NM_001128431	NP_001121903			solute carrier family 39 (zinc transporter),							endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity				0				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)														---	---	---	---
PBK	55872	broad.mit.edu	37	8	27697882	27697882	+	5'Flank	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27697882delA	uc003xgi.2	-						PBK_uc011lap.1_5'Flank	NM_018492	NP_060962			PDZ binding kinase						mitosis		ATP binding|protein binding|protein serine/threonine kinase activity				0		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|KIRC - Kidney renal clear cell carcinoma(542;0.101)|Kidney(114;0.121)|Colorectal(74;0.141)														---	---	---	---
UBXN8	7993	broad.mit.edu	37	8	30608867	30608867	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30608867delA	uc003xii.2	+						UBXN8_uc010lvi.2_Intron|UBXN8_uc011lbb.1_Intron|UBXN8_uc003xij.2_5'Flank	NM_005671	NP_005662			reproduction 8						single fertilization						0																		---	---	---	---
RNF122	79845	broad.mit.edu	37	8	33408285	33408285	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:33408285delG	uc003xjo.1	-							NM_024787	NP_079063			ring finger protein 122							endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)														---	---	---	---
ADAM32	203102	broad.mit.edu	37	8	39008784	39008785	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39008784_39008785insA	uc003xmt.3	+						ADAM32_uc011lch.1_Intron|ADAM32_uc003xmu.3_Intron	NM_145004	NP_659441			a disintegrin and metalloprotease domain 32						proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)															---	---	---	---
ADAM2	2515	broad.mit.edu	37	8	39694881	39694881	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39694881delT	uc003xnj.2	-						ADAM2_uc003xnk.2_Intron|ADAM2_uc011lck.1_Intron|ADAM2_uc003xnl.2_Intron	NM_001464	NP_001455			ADAM metallopeptidase domain 2 proprotein						cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)														---	---	---	---
SLC20A2	6575	broad.mit.edu	37	8	42297283	42297283	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42297283delA	uc010lxl.2	-						SLC20A2_uc010lxm.2_Intron|SLC20A2_uc003xpe.2_Intron|SLC20A2_uc011lcu.1_Intron	NM_006749	NP_006740			solute carrier family 20, member 2						interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			ovary(2)	2	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)															---	---	---	---
SNAI2	6591	broad.mit.edu	37	8	49834011	49834011	+	5'Flank	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:49834011delT	uc003xqp.2	-							NM_003068	NP_003059			snail 2						canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)																---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61714076	61714076	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61714076delT	uc003xue.2	+							NM_017780	NP_060250			chromodomain helicase DNA binding protein 7						central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
CSPP1	79848	broad.mit.edu	37	8	68044403	68044403	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68044403delA	uc003xxi.2	+						CSPP1_uc003xxg.1_Intron|CSPP1_uc003xxh.1_Intron|CSPP1_uc003xxj.2_Intron|CSPP1_uc003xxk.2_Intron	NM_001077204	NP_001070672			centrosome spindle pole associated protein 1							centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)															---	---	---	---
TERF1	7013	broad.mit.edu	37	8	73925972	73925972	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:73925972delT	uc003xzd.2	+						TERF1_uc003xzc.2_Intron|TERF1_uc003xze.2_Intron	NM_017489	NP_059523			telomeric repeat binding factor 1 isoform 1						age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			ovary(1)|lung(1)|skin(1)	3	Breast(64;0.218)		Epithelial(68;0.0984)															---	---	---	---
UBE2W	55284	broad.mit.edu	37	8	74782628	74782628	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:74782628delA	uc003xzv.2	-						UBE2W_uc003xzt.2_Intron|UBE2W_uc003xzu.2_Intron|UBE2W_uc003xzw.2_Intron	NM_018299	NP_060769			ubiquitin-conjugating enzyme E2W (putative)						protein K11-linked ubiquitination|protein monoubiquitination		ATP binding|protein binding|ubiquitin-protein ligase activity				0	Breast(64;0.0311)		Epithelial(68;0.0235)|all cancers(69;0.0687)|BRCA - Breast invasive adenocarcinoma(89;0.069)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	74897026	74897026	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:74897026delT								TMEM70 (2015 upstream) : LY96 (6561 downstream)																																			---	---	---	---
HNF4G	3174	broad.mit.edu	37	8	76463542	76463542	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:76463542delA	uc003yaq.2	+						HNF4G_uc003yar.2_Intron	NM_004133	NP_004124			hepatocyte nuclear factor 4, gamma						endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)															---	---	---	---
WWP1	11059	broad.mit.edu	37	8	87393245	87393246	+	Intron	DEL	TT	-	-	rs79348529	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:87393245_87393246delTT	uc003ydt.2	+						WWP1_uc010mai.2_Intron	NM_007013	NP_008944			WW domain containing E3 ubiquitin protein ligase						central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2																		---	---	---	---
OTUD6B	51633	broad.mit.edu	37	8	92096993	92096993	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:92096993delT	uc003yeu.3	+						OTUD6B_uc011lgh.1_Intron	NM_016023	NP_057107			OTU domain containing 6B											ovary(2)|lung(1)	3			BRCA - Breast invasive adenocarcinoma(11;0.0187)															---	---	---	---
RUNX1T1	862	broad.mit.edu	37	8	92998987	92998987	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:92998987delT	uc003yfd.2	-						RUNX1T1_uc003yfc.1_Intron|RUNX1T1_uc003yfe.1_Intron|RUNX1T1_uc010mao.2_Intron|RUNX1T1_uc011lgi.1_Intron|RUNX1T1_uc010man.1_Intron|RUNX1T1_uc003yfb.1_Intron	NM_175634	NP_783552			acute myelogenous leukemia 1 translocation 1						generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)															---	---	---	---
CDH17	1015	broad.mit.edu	37	8	95182985	95182985	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95182985delT	uc003ygh.2	-						CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Intron	NM_004063	NP_004054			cadherin 17 precursor							integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)															---	---	---	---
INTS8	55656	broad.mit.edu	37	8	95888859	95888860	+	Intron	INS	-	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95888859_95888860insT	uc003yhb.2	+						INTS8_uc011lgq.1_Intron|INTS8_uc011lgr.1_Intron|INTS8_uc010mba.2_Intron	NM_017864	NP_060334			integrator complex subunit 8						snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)																	---	---	---	---
OSR2	116039	broad.mit.edu	37	8	99962748	99962748	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99962748delA	uc003yir.2	+						OSR2_uc010mbn.2_Intron|OSR2_uc003yiq.2_Intron|OSR2_uc011lgx.1_Intron	NM_001142462	NP_001135934			odd-skipped related 2 isoform a						bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103358988	103358988	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103358988delA	uc003ykr.1	-						UBR5_uc003yks.1_Intron	NM_015902	NP_056986			ubiquitin protein ligase E3 component n-recognin						cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
PTK2	5747	broad.mit.edu	37	8	141810338	141810339	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141810338_141810339delTT	uc003yvu.2	-						PTK2_uc011ljq.1_Intron|PTK2_uc003yvp.2_Intron|PTK2_uc003yvq.2_Intron|PTK2_uc003yvr.2_Intron|PTK2_uc003yvs.2_Intron|PTK2_uc003yvt.2_Intron|PTK2_uc003yvv.2_Intron|PTK2_uc011ljr.1_Intron	NM_153831	NP_722560			PTK2 protein tyrosine kinase 2 isoform a						axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)															---	---	---	---
VLDLR	7436	broad.mit.edu	37	9	2648962	2648962	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2648962delT	uc003zhk.1	+						VLDLR_uc003zhl.1_Intron|VLDLR_uc003zhm.1_Intron|VLDLR_uc003zhn.1_Intron	NM_003383	NP_003374			very low density lipoprotein receptor isoform a						cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)														---	---	---	---
KIAA2026	158358	broad.mit.edu	37	9	5924455	5924456	+	Intron	INS	-	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5924455_5924456insT	uc003zjq.3	-						KIAA2026_uc010mht.2_Intron	NM_001017969	NP_001017969			hypothetical protein LOC158358											ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)														---	---	---	---
DENND4C	55667	broad.mit.edu	37	9	19345769	19345769	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19345769delT	uc003znq.2	+						DENND4C_uc011lnc.1_Intron|DENND4C_uc011lnd.1_Intron|DENND4C_uc003znr.2_Intron|DENND4C_uc003zns.2_Intron|DENND4C_uc003znt.2_5'Flank	NM_017925	NP_060395			DENN/MADD domain containing 4C							integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
MTAP	4507	broad.mit.edu	37	9	21815552	21815553	+	Intron	INS	-	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:21815552_21815553insT	uc003zph.2	+						MTAP_uc003zpi.1_Intron|MTAP_uc010mit.2_Intron|MTAP_uc011lnk.1_Intron|MTAP_uc011lnl.1_5'Flank	NM_002451	NP_002442			5'-methylthioadenosine phosphorylase						nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity			central_nervous_system(1)	1		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)													---	---	---	---
ACO1	48	broad.mit.edu	37	9	32429380	32429380	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32429380delT	uc003zqw.3	+						ACO1_uc010mjh.1_Intron|ACO1_uc003zqx.3_Intron|ACO1_uc003zqy.3_Intron	NM_002197	NP_002188			aconitase 1						citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)														---	---	---	---
TOPORS	10210	broad.mit.edu	37	9	32541246	32541246	+	3'UTR	DEL	A	-	-	rs78113455		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32541246delA	uc003zrb.2	-	3					TOPORS_uc003zrc.2_3'UTR	NM_005802	NP_005793			topoisomerase I binding, arginine/serine-rich						DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)														---	---	---	---
RECK	8434	broad.mit.edu	37	9	36123173	36123173	+	3'UTR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36123173delT	uc003zyv.2	+	21					RECK_uc003zyw.2_3'UTR|RECK_uc003zyx.2_RNA	NM_021111	NP_066934			RECK protein precursor							anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
MELK	9833	broad.mit.edu	37	9	36671220	36671220	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36671220delT	uc003zzn.2	+						MELK_uc011lpm.1_Intron|MELK_uc011lpn.1_Intron|MELK_uc011lpo.1_Intron|MELK_uc010mll.2_Intron|MELK_uc011lpp.1_Intron|MELK_uc010mlm.2_Intron|MELK_uc011lpq.1_Intron|MELK_uc011lpr.1_Intron|MELK_uc011lps.1_Intron	NM_014791	NP_055606			maternal embryonic leucine zipper kinase							cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
Unknown	0	broad.mit.edu	37	9	69721737	69721737	+	IGR	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:69721737delG								LOC100133920 (56788 upstream) : FOXD4L5 (453972 downstream)																																			---	---	---	---
VPS13A	23230	broad.mit.edu	37	9	79842991	79842992	+	Intron	DEL	TA	-	-	rs34249411		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79842991_79842992delTA	uc004akr.2	+						VPS13A_uc004akp.3_Intron|VPS13A_uc004akq.3_Intron|VPS13A_uc004aks.2_Intron	NM_033305	NP_150648			vacuolar protein sorting 13A isoform A						Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10																		---	---	---	---
ZCCHC6	79670	broad.mit.edu	37	9	88952316	88952316	+	Intron	DEL	A	-	-	rs73650944		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88952316delA	uc004aoq.2	-						ZCCHC6_uc011ltf.1_Intron|ZCCHC6_uc004aor.2_Intron|ZCCHC6_uc004aos.2_Intron|ZCCHC6_uc004aot.2_Intron|ZCCHC6_uc004aou.2_Intron|ZCCHC6_uc004aov.2_3'UTR	NM_024617	NP_078893			zinc finger, CCHC domain containing 6						RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
HIATL1	84641	broad.mit.edu	37	9	97218372	97218373	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:97218372_97218373delAA	uc004aur.2	+						HIATL1_uc011luh.1_Intron	NM_032558	NP_115947			hippocampus abundant transcript-like 1						transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)																---	---	---	---
FANCC	2176	broad.mit.edu	37	9	98009495	98009496	+	Intron	DEL	GT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:98009495_98009496delGT	uc004avh.2	-						FANCC_uc004avi.3_Intron|FANCC_uc010mrm.1_Intron|FANCC_uc011lul.1_Intron	NM_000136	NP_000127			Fanconi anemia, complementation group C						protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)	1		Acute lymphoblastic leukemia(62;0.138)						D|Mis|N|F|S			AML|leukemia		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
ZNF462	58499	broad.mit.edu	37	9	109736291	109736291	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:109736291delT	uc004bcz.2	+						ZNF462_uc010mto.2_Intron|ZNF462_uc004bda.2_Intron|ZNF462_uc011lvz.1_Intron|ZNF462_uc004bdb.1_Intron	NM_021224	NP_067047			zinc finger protein 462						transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5																		---	---	---	---
CTNNAL1	8727	broad.mit.edu	37	9	111705155	111705155	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111705155delA	uc004bdo.1	-						CTNNAL1_uc010mts.1_Intron|CTNNAL1_uc010mtt.1_Intron|CTNNAL1_uc004bdp.1_Intron|CTNNAL1_uc004bdq.1_Intron	NM_003798	NP_003789			catenin, alpha-like 1						cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)														---	---	---	---
EPB41L4B	54566	broad.mit.edu	37	9	112042266	112042266	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:112042266delA	uc004bdz.1	-						EPB41L4B_uc004bea.2_Intron	NM_019114	NP_061987			erythrocyte membrane protein band 4.1 like 4B							cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
KIAA0368	23392	broad.mit.edu	37	9	114174440	114174440	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114174440delA	uc004bfe.1	-							NM_001080398	NP_001073867			KIAA0368 protein												0																		---	---	---	---
KIAA0368	23392	broad.mit.edu	37	9	114195316	114195316	+	Intron	DEL	C	-	-	rs11335472		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114195316delC	uc004bfe.1	-						KIAA0368_uc010muc.1_Intron	NM_001080398	NP_001073867			KIAA0368 protein												0																		---	---	---	---
GSN	2934	broad.mit.edu	37	9	124074857	124074857	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124074857delA	uc004blf.1	+						GSN_uc004bld.1_Intron|GSN_uc010mvq.1_Intron|GSN_uc010mvr.1_Intron|GSN_uc010mvu.1_Intron|GSN_uc010mvt.1_Intron|GSN_uc010mvs.1_Intron|GSN_uc004ble.1_Intron|GSN_uc010mvv.1_Intron|GSN_uc011lyh.1_Intron|GSN_uc011lyi.1_Intron|GSN_uc011lyj.1_Intron|GSN_uc004blg.1_Intron	NM_000177	NP_000168			gelsolin isoform a precursor						actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3																		---	---	---	---
STRBP	55342	broad.mit.edu	37	9	125887690	125887693	+	3'UTR	DEL	TTTT	-	-	rs34536381		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125887690_125887693delTTTT	uc004bns.2	-	19					STRBP_uc004bnt.2_3'UTR|STRBP_uc004bnu.2_3'UTR|STRBP_uc004bnv.2_3'UTR|STRBP_uc004bnr.2_3'UTR	NM_018387	NP_060857			spermatid perinuclear RNA binding protein						multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2																		---	---	---	---
GARNL3	84253	broad.mit.edu	37	9	130062292	130062292	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130062292delT	uc011mae.1	+						GARNL3_uc011mad.1_Intron	NM_032293	NP_115669			GTPase activating Rap/RanGAP domain-like 3						regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
GTF3C4	9329	broad.mit.edu	37	9	135546500	135546500	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135546500delA	uc010mzv.2	+						DDX31_uc004cbq.1_5'Flank|DDX31_uc010mzu.1_5'Flank|DDX31_uc004cbr.1_5'Flank|DDX31_uc004cbs.1_5'Flank|GTF3C4_uc010mzw.2_Intron	NM_012204	NP_036336			general transcription factor IIIC 4						transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)														---	---	---	---
Unknown	0	broad.mit.edu	37	9	139674473	139674474	+	IGR	DEL	AG	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139674473_139674474delAG								LCN15 (15508 upstream) : TMEM141 (11303 downstream)																																			---	---	---	---
PNPLA7	375775	broad.mit.edu	37	9	140396079	140396079	+	Intron	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140396079delC	uc004cnf.2	-						C9orf167_uc011mew.1_Intron|PNPLA7_uc011mfa.1_Intron|PNPLA7_uc010ncj.1_Intron	NM_152286	NP_689499			patatin-like phospholipase domain containing 7						lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)														---	---	---	---
ZMYND19	116225	broad.mit.edu	37	9	140482898	140482907	+	Intron	DEL	GTGGGCCACA	-	-	rs3831164		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140482898_140482907delGTGGGCCACA	uc004cno.1	-							NM_138462	NP_612471			zinc finger, MYND domain containing 19							Golgi apparatus|plasma membrane	zinc ion binding			skin(1)	1	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)														---	---	---	---
PFKP	5214	broad.mit.edu	37	10	3174816	3174819	+	Intron	DEL	AACT	-	-	rs72145058		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:3174816_3174819delAACT	uc001igp.2	+						PFKP_uc001igq.2_Intron|PFKP_uc009xhr.2_Intron|PFKP_uc009xht.2_Intron|PFKP_uc009xhu.2_Intron	NM_002627	NP_002618			phosphofructokinase, platelet						glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)														---	---	---	---
HSPA14	51182	broad.mit.edu	37	10	14908968	14908968	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:14908968delT	uc001inf.2	+							NM_016299	NP_057383			heat shock 70kDa protein 14 isoform 1						'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			ovary(2)|breast(2)|lung(1)	5																		---	---	---	---
PLXDC2	84898	broad.mit.edu	37	10	20436538	20436538	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:20436538delA	uc001iqg.1	+						PLXDC2_uc001iqh.1_Intron|PLXDC2_uc009xkc.1_Intron	NM_032812	NP_116201			plexin domain containing 2 precursor							integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
WAC	51322	broad.mit.edu	37	10	28879632	28879632	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:28879632delT	uc001iuf.2	+						WAC_uc001iud.2_Intron|WAC_uc001iue.2_Intron|WAC_uc009xlb.2_Intron|WAC_uc001iug.2_Intron|WAC_uc001iuh.2_Intron	NM_016628	NP_057712			WW domain-containing adapter with a coiled-coil						cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
KIF5B	3799	broad.mit.edu	37	10	32309770	32309770	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:32309770delA	uc001iwe.3	-							NM_004521	NP_004512			kinesin family member 5B						stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)																---	---	---	---
PARD3	56288	broad.mit.edu	37	10	34572884	34572884	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:34572884delT	uc010qej.1	-						PARD3_uc010qek.1_Intron|PARD3_uc010qel.1_Intron|PARD3_uc010qem.1_Intron|PARD3_uc010qen.1_Intron|PARD3_uc010qeo.1_Intron|PARD3_uc010qep.1_Intron|PARD3_uc010qeq.1_Intron	NM_019619	NP_062565			partitioning-defective protein 3 homolog						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)																---	---	---	---
PARG	8505	broad.mit.edu	37	10	51130801	51130802	+	Intron	INS	-	TA	TA	rs140815608		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:51130801_51130802insTA	uc001jif.2	-						PARG_uc001jih.2_Intron|PARG_uc001jig.2_Intron|PARG_uc010qgv.1_Intron|PARG_uc009xoi.2_Intron|PARG_uc010qgw.1_Intron|PARG_uc009xoj.2_Intron|PARG_uc010qgx.1_Intron	NM_003631	NP_003622			poly (ADP-ribose) glycohydrolase						carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity			ovary(2)	2				Epithelial(53;0.213)														---	---	---	---
RHOBTB1	9886	broad.mit.edu	37	10	62670493	62670493	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:62670493delT	uc001jli.2	-						RHOBTB1_uc001jlh.2_Intron|RHOBTB1_uc001jlj.2_Intron|RHOBTB1_uc001jlk.2_Intron|RHOBTB1_uc009xpe.1_Intron|RHOBTB1_uc001jlm.2_3'UTR	NM_014836	NP_055651			Rho-related BTB domain containing 1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)																	---	---	---	---
Unknown	0	broad.mit.edu	37	10	70304123	70304124	+	IGR	DEL	TT	-	-	rs71716010		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70304123_70304124delTT								SLC25A16 (16539 upstream) : TET1 (15993 downstream)																																			---	---	---	---
TET1	80312	broad.mit.edu	37	10	70392079	70392079	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70392079delA	uc001jok.3	+							NM_030625	NP_085128			CXXC finger 6						DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9																		---	---	---	---
Unknown	0	broad.mit.edu	37	10	71551637	71551638	+	IGR	INS	-	CACCACCAC	CACCACCAC	rs139707397	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71551637_71551638insCACCACCAC								C10orf35 (158290 upstream) : COL13A1 (10006 downstream)																																			---	---	---	---
OIT3	170392	broad.mit.edu	37	10	74683837	74683837	+	Intron	DEL	A	-	-	rs112952142		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74683837delA	uc001jte.1	+						OIT3_uc009xqs.1_Intron	NM_152635	NP_689848			oncoprotein-induced transcript 3 precursor							nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)																	---	---	---	---
VCL	7414	broad.mit.edu	37	10	75803110	75803110	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75803110delT	uc001jwd.2	+						VCL_uc009xrr.2_Intron|VCL_uc010qky.1_Intron|VCL_uc001jwe.2_Intron|VCL_uc010qkz.1_Intron	NM_014000	NP_054706			vinculin isoform meta-VCL						adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)																	---	---	---	---
ANKRD1	27063	broad.mit.edu	37	10	92680593	92680593	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:92680593delT	uc001khe.1	-							NM_014391	NP_055206			cardiac ankyrin repeat protein						cellular lipid metabolic process|defense response|signal transduction		DNA binding				0		Colorectal(252;0.0475)																---	---	---	---
KIF11	3832	broad.mit.edu	37	10	94399351	94399351	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94399351delA	uc001kic.2	+						KIF11_uc010qnq.1_Intron	NM_004523	NP_004514			kinesin family member 11						blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1																		---	---	---	---
NOC3L	64318	broad.mit.edu	37	10	96094287	96094287	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96094287delA	uc001kjq.1	-							NM_022451	NP_071896			nucleolar complex associated 3 homolog							nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)																---	---	---	---
MMS19	64210	broad.mit.edu	37	10	99226748	99226748	+	Intron	DEL	T	-	-	rs67140194		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99226748delT	uc001kns.3	-						MMS19_uc009xvs.2_Intron|MMS19_uc009xvt.2_Intron|MMS19_uc001knr.2_Intron|MMS19_uc010qox.1_Intron|MMS19_uc001knt.2_Intron|MMS19_uc001knu.1_Intron	NM_022362	NP_071757			MMS19 nucleotide excision repair homolog						chromosome segregation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent|two-component signal transduction system (phosphorelay)	cytoplasm|holo TFIIH complex|MMXD complex	estrogen receptor binding|protein binding, bridging|receptor signaling complex scaffold activity|transcription coactivator activity				0		Colorectal(252;0.0846)		Epithelial(162;3.33e-10)|all cancers(201;2.74e-08)									Direct_reversal_of_damage|NER					---	---	---	---
PI4K2A	55361	broad.mit.edu	37	10	99361780	99361780	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99361780delG	uc010qoy.1	+						DHDPSL_uc001kny.2_Intron|DHDPSL_uc001knz.2_Intron	NM_018425	NP_060895			phosphatidylinositol 4-kinase type 2 alpha						phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			lung(1)|skin(1)	2		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)														---	---	---	---
SEC31B	25956	broad.mit.edu	37	10	102275671	102275672	+	Intron	INS	-	G	G	rs143845466	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102275671_102275672insG	uc001krc.1	-						SEC31B_uc010qpo.1_Intron|SEC31B_uc001krd.1_Intron|SEC31B_uc001krf.1_Intron|SEC31B_uc001kre.1_Intron|SEC31B_uc010qpp.1_Intron|SEC31B_uc009xwn.1_Intron|SEC31B_uc009xwo.1_Intron|SEC31B_uc010qpq.1_Intron|SEC31B_uc010qpr.1_Intron	NM_015490	NP_056305			SEC31 homolog B						protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)														---	---	---	---
GBF1	8729	broad.mit.edu	37	10	104120909	104120909	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104120909delA	uc001kux.1	+						GBF1_uc001kuy.1_Intron|GBF1_uc001kuz.1_Intron	NM_004193	NP_004184			golgi-specific brefeldin A resistant guanine						COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)														---	---	---	---
PDCD11	22984	broad.mit.edu	37	10	105186868	105186868	+	Intron	DEL	A	-	-	rs75558099		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105186868delA	uc001kwy.1	+							NM_014976	NP_055791			programmed cell death 11						mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)														---	---	---	---
VTI1A	143187	broad.mit.edu	37	10	114297977	114297977	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:114297977delT	uc001kzy.2	+						VTI1A_uc001kzz.2_Intron	NM_145206	NP_660207			SNARE Vti1a-beta protein						intracellular protein transport|retrograde transport, endosome to Golgi	SNARE complex	protein transporter activity|SNAP receptor activity			ovary(1)	1		Colorectal(252;0.0314)|Breast(234;0.183)		Epithelial(162;0.0126)|all cancers(201;0.0487)														---	---	---	---
ATRNL1	26033	broad.mit.edu	37	10	116887545	116887545	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116887545delT	uc001lcg.2	+						ATRNL1_uc001lce.2_Intron|ATRNL1_uc001lcf.2_Intron|ATRNL1_uc009xyq.2_Intron	NM_207303	NP_997186			attractin-like 1 precursor							integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)														---	---	---	---
ANO9	338440	broad.mit.edu	37	11	429820	429821	+	Splice_Site	INS	-	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:429820_429821insG	uc001lpi.2	-	10	857	c.772_splice	c.e10-1	p.L258_splice	ANO9_uc001lph.2_5'UTR|ANO9_uc010qvv.1_Splice_Site_p.L114_splice	NM_001012302	NP_001012302			tumor protein p53 inducible protein 5							chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4																		---	---	---	---
NUP98	4928	broad.mit.edu	37	11	3723511	3723518	+	Intron	DEL	ACACACAC	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:3723511_3723518delACACACAC	uc001lyh.2	-						NUP98_uc001lyi.2_Intron|NUP98_uc001lyg.2_Intron	NM_016320	NP_057404			nucleoporin 98kD isoform 1						carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)				T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								---	---	---	---
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	-	-	rs3812754	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:12316384_12316389delCTCCTA	uc001mkg.1	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)CCTCCTACA>CCA	p.PT470del		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	470_471					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)														---	---	---	---
HTATIP2	10553	broad.mit.edu	37	11	20404503	20404503	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20404503delT	uc009yia.1	+						HTATIP2_uc009yib.1_Intron|HTATIP2_uc001mpx.2_Intron|HTATIP2_uc001mpz.2_Intron	NM_006410	NP_006401			HIV-1 Tat interactive protein 2, 30kDa isoform						angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity				0																		---	---	---	---
ELP4	26610	broad.mit.edu	37	11	31561001	31561001	+	Intron	DEL	A	-	-	rs76954383		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:31561001delA	uc001mtb.2	+						ELP4_uc001mta.1_Intron|ELP4_uc001mtc.2_Intron|ELP4_uc010rdz.1_Intron	NM_019040	NP_061913			elongation protein 4 homolog						histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)																	---	---	---	---
ARFGAP2	84364	broad.mit.edu	37	11	47189417	47189418	+	Intron	DEL	AA	-	-	rs34204386		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47189417_47189418delAA	uc001ndt.2	-						ARFGAP2_uc010rha.1_Intron|ARFGAP2_uc010rhb.1_Intron|ARFGAP2_uc001ndu.2_Intron|ARFGAP2_uc010rhc.1_Intron	NM_032389	NP_115765			ADP-ribosylation factor GTPase activating						protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			ovary(1)	1																		---	---	---	---
FOLH1	2346	broad.mit.edu	37	11	49175356	49175357	+	Intron	INS	-	AC	AC			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49175356_49175357insAC	uc001ngy.2	-						FOLH1_uc001ngx.2_Intron|FOLH1_uc001ngz.2_Intron|FOLH1_uc009yly.2_Intron|FOLH1_uc009ylz.2_Intron|FOLH1_uc009yma.2_Intron	NM_004476	NP_004467			folate hydrolase 1 isoform 1						proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)													---	---	---	---
CTNND1	1500	broad.mit.edu	37	11	57582848	57582849	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57582848_57582849delTT	uc001nmc.3	+						CTNND1_uc001nlh.1_Intron|CTNND1_uc001nlu.3_Intron|CTNND1_uc001nlt.3_Intron|CTNND1_uc001nls.3_Intron|CTNND1_uc001nlw.3_Intron|CTNND1_uc001nmf.3_Intron|CTNND1_uc001nmd.3_Intron|CTNND1_uc001nlk.3_Intron|CTNND1_uc001nme.3_Intron|CTNND1_uc001nll.3_Intron|CTNND1_uc001nmg.3_Intron|CTNND1_uc001nlj.3_Intron|CTNND1_uc001nlr.3_Intron|CTNND1_uc001nlp.3_Intron|CTNND1_uc001nlx.3_Intron|CTNND1_uc001nlz.3_Intron|CTNND1_uc009ymn.2_Intron|CTNND1_uc001nlm.3_Intron|CTNND1_uc001nly.3_Intron|CTNND1_uc001nmb.3_Intron|CTNND1_uc001nma.3_Intron|CTNND1_uc001nmi.3_Intron|CTNND1_uc001nmh.3_Intron|CTNND1_uc001nlq.3_Intron|CTNND1_uc001nln.3_Intron|CTNND1_uc001nli.3_Intron|CTNND1_uc001nlo.3_Intron|CTNND1_uc001nlv.3_Intron	NM_001085458	NP_001078927			catenin, delta 1 isoform 1ABC						adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)																---	---	---	---
Unknown	0	broad.mit.edu	37	11	59997717	59997718	+	5'Flank	DEL	GA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59997717_59997718delGA	uc001nov.2	-						uc001now.2_5'Flank|uc001nox.2_5'Flank|uc001noy.2_5'Flank|uc009ymw.2_5'Flank					Homo sapiens mRNA for hypothetical protein, partial cds, clone:Hsa11-digit17-05-01-R.																														---	---	---	---
KDM2A	22992	broad.mit.edu	37	11	66983146	66983147	+	Intron	DEL	AA	-	-	rs113780245	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66983146_66983147delAA	uc001ojw.2	+						KDM2A_uc001ojx.2_Intron|KDM2A_uc001ojy.2_Intron	NM_012308	NP_036440			F-box and leucine-rich repeat protein 11						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9																		---	---	---	---
NDUFV1	4723	broad.mit.edu	37	11	67377309	67377310	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67377309_67377310delTT	uc001omj.2	+						NDUFV1_uc010rpv.1_Intron|NDUFV1_uc001oml.2_Intron|NDUFV1_uc001omk.3_Intron|NDUFV1_uc009yrz.1_Intron|NDUFV1_uc010rpw.1_5'Flank	NM_007103	NP_009034			NADH dehydrogenase ubiquinone flavoprotein 1						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)													---	---	---	---
LRP5	4041	broad.mit.edu	37	11	68131125	68131126	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68131125_68131126delAA	uc001ont.2	+						LRP5_uc009ysg.2_Intron	NM_002335	NP_002326			low density lipoprotein receptor-related protein						adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7																		---	---	---	---
MTL5	9633	broad.mit.edu	37	11	68517872	68517872	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68517872delC	uc001ooc.2	-	2	397	c.257delG	c.(256-258)GGCfs	p.G86fs	MTL5_uc001ood.1_Frame_Shift_Del_p.G86fs|MTL5_uc009ysi.1_Frame_Shift_Del_p.G86fs|MTL5_uc001ooe.2_Frame_Shift_Del_p.G86fs	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	86					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)															---	---	---	---
PDE2A	5138	broad.mit.edu	37	11	72292791	72292791	+	Intron	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:72292791delC	uc010rrc.1	-						PDE2A_uc001oso.2_Intron|PDE2A_uc010rra.1_Intron|PDE2A_uc001osn.2_Intron|PDE2A_uc010rrb.1_Intron|PDE2A_uc010rrd.1_Intron	NM_002599	NP_002590			phosphodiesterase 2A isoform 1						platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)													---	---	---	---
ARAP1	116985	broad.mit.edu	37	11	72417049	72417050	+	Intron	INS	-	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:72417049_72417050insG	uc001osu.2	-						ARAP1_uc001osv.2_Intron|ARAP1_uc001osr.2_Intron|ARAP1_uc001oss.2_Intron|ARAP1_uc009yth.2_Intron|ARAP1_uc010rre.1_Intron|ARAP1_uc001osw.1_5'Flank	NM_001040118	NP_001035207			ArfGAP with RhoGAP domain, ankyrin repeat and PH						actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1																		---	---	---	---
C2CD3	26005	broad.mit.edu	37	11	73795769	73795770	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73795769_73795770insA	uc001ouu.2	-						C2CD3_uc001out.2_Intron	NM_015531	NP_056346			C2 calcium-dependent domain containing 3							centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)																	---	---	---	---
CCDC90B	60492	broad.mit.edu	37	11	82989635	82989635	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82989635delT	uc001pae.2	-						CCDC90B_uc001pac.2_Intron|CCDC90B_uc001pad.2_Intron|CCDC90B_uc001paf.2_Intron	NM_021825	NP_068597			coiled-coil domain containing 90B precursor							integral to membrane|mitochondrion|mitochondrion					0		Acute lymphoblastic leukemia(157;0.103)																---	---	---	---
PRSS23	11098	broad.mit.edu	37	11	86544047	86544048	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:86544047_86544048delAA	uc001pcc.1	+						uc001pcd.2_Intron					Homo sapiens serine protease mRNA, complete cds.						proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
NAALAD2	10003	broad.mit.edu	37	11	89925063	89925064	+	3'UTR	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89925063_89925064delTT	uc001pdf.3	+	19					NAALAD2_uc009yvx.2_3'UTR|NAALAD2_uc009yvy.2_3'UTR	NM_005467	NP_005458			N-acetylated alpha-linked acidic dipeptidase 2						proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)																---	---	---	---
MRE11A	4361	broad.mit.edu	37	11	94203462	94203462	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94203462delA	uc001peu.2	-						MRE11A_uc001pev.2_Intron|MRE11A_uc009ywj.2_Intron	NM_005591	NP_005582			meiotic recombination 11 homolog A isoform 1						DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(4)|lung(1)	5		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)											Homologous_recombination	Ataxia-Telangiectasia-Like_Disorder				---	---	---	---
PIWIL4	143689	broad.mit.edu	37	11	94349640	94349640	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94349640delT	uc001pfa.2	+						PIWIL4_uc010rue.1_Intron|PIWIL4_uc009ywk.1_Intron	NM_152431	NP_689644			piwi-like 4						cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)																---	---	---	---
ACAT1	38	broad.mit.edu	37	11	108004840	108004840	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108004840delA	uc001pjy.2	+						ACAT1_uc001pjw.1_Intron|ACAT1_uc001pjx.2_Intron	NM_000019	NP_000010			acetyl-Coenzyme A acetyltransferase 1 precursor						acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			ovary(3)	3		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)													---	---	---	---
Unknown	0	broad.mit.edu	37	11	113662178	113662178	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113662178delA								CLDN25 (10971 upstream) : USP28 (6420 downstream)																																			---	---	---	---
BUD13	84811	broad.mit.edu	37	11	116631787	116631789	+	Intron	DEL	TTT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116631787_116631789delTTT	uc001ppn.2	-						BUD13_uc001ppo.2_Intron|BUD13_uc009yzc.2_Intron	NM_032725	NP_116114			BUD13 homolog isoform 1											large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)														---	---	---	---
MLL	4297	broad.mit.edu	37	11	118380456	118380456	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118380456delA	uc001pta.2	+						MLL_uc001ptb.2_Intron	NM_005933	NP_005924			myeloid/lymphoid or mixed-lineage leukemia						apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
CBL	867	broad.mit.edu	37	11	119148323	119148323	+	Intron	DEL	T	-	-	rs79470692		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119148323delT	uc001pwe.2	+							NM_005188	NP_005179			Cas-Br-M (murine) ecotropic retroviral						epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)										CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				---	---	---	---
HEPACAM	220296	broad.mit.edu	37	11	124793528	124793528	+	Intron	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124793528delC	uc001qbk.2	-						HEPACAM_uc009zbj.2_5'Flank|HEPACAM_uc001qbl.1_Intron	NM_152722	NP_689935			hepatocyte cell adhesion molecule precursor						cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)														---	---	---	---
EI24	9538	broad.mit.edu	37	11	125452395	125452395	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125452395delA	uc001qca.2	+						EI24_uc001qcb.2_Intron|EI24_uc010sbd.1_Intron|EI24_uc009zbl.2_Intron|EI24_uc001qcc.2_Intron|EI24_uc010sbe.1_Intron|EI24_uc010sbf.1_Intron	NM_004879	NP_004870			etoposide induced 2.4 isoform 1						apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)														---	---	---	---
NCAPD3	23310	broad.mit.edu	37	11	134090261	134090261	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134090261delA	uc001qhd.1	-						NCAPD3_uc010scm.1_Intron|NCAPD3_uc009zda.1_Intron	NM_015261	NP_056076			non-SMC condensin II complex, subunit D3						cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)														---	---	---	---
ERC1	23085	broad.mit.edu	37	12	1137798	1137798	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1137798delT	uc001qjb.2	+						ERC1_uc001qiz.2_Intron|ERC1_uc001qjc.2_Intron|ERC1_uc001qja.2_Intron|ERC1_uc001qjd.2_Intron|ERC1_uc001qjf.2_Intron	NM_178040	NP_829884			RAB6-interacting protein 2 isoform epsilon						I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)															---	---	---	---
CACNA2D4	93589	broad.mit.edu	37	12	1909657	1909657	+	Intron	DEL	C	-	-	rs111637110		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1909657delC	uc001qjp.2	-						CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc001qjo.2_Intron|CACNA2D4_uc001qjs.1_Intron|CACNA2D4_uc010sdw.1_Intron|CACNA2D4_uc009zdr.1_Intron	NM_172364	NP_758952			voltage-gated calcium channel alpha(2)delta-4							integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)												OREG0021569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NCAPD2	9918	broad.mit.edu	37	12	6640676	6640679	+	3'UTR	DEL	TTAA	-	-	rs75240003	by1000genomes;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6640676_6640679delTTAA	uc001qoo.2	+	32					NCAPD2_uc010sfd.1_3'UTR|GAPDH_uc001qop.1_5'Flank|GAPDH_uc009zep.1_5'Flank|GAPDH_uc001qoq.1_5'Flank|GAPDH_uc001qor.1_5'Flank	NM_014865	NP_055680			non-SMC condensin I complex, subunit D2						cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5																		---	---	---	---
SLC2A3	6515	broad.mit.edu	37	12	8084184	8084184	+	Intron	DEL	T	-	-	rs76797177		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8084184delT	uc001qtr.2	-						SLC2A3_uc001qts.2_Intron	NM_006931	NP_008862			solute carrier family 2 (facilitated glucose						carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)														---	---	---	---
RIMKLB	57494	broad.mit.edu	37	12	8906367	8906367	+	Intron	DEL	A	-	-	rs146605560		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8906367delA	uc001quu.2	+						RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_Intron|RIMKLB_uc010sgl.1_Intron|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785			ribosomal modification protein rimK-like family						protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0																		---	---	---	---
CLEC9A	283420	broad.mit.edu	37	12	10197962	10197962	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10197962delT	uc001qxa.2	+							NM_207345	NP_997228			C-type lectin domain family 9, member A						positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1																		---	---	---	---
KLRC3	3823	broad.mit.edu	37	12	10588795	10588795	+	5'Flank	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10588795delT	uc001qyh.2	-						KLRC2_uc010she.1_5'Flank|KLRC2_uc001qyk.2_5'Flank	NM_002261	NP_002252			killer cell lectin-like receptor subfamily C,						cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3																		---	---	---	---
LRP6	4040	broad.mit.edu	37	12	12273985	12273985	+	3'UTR	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:12273985delC	uc001rah.3	-	23					BCL2L14_uc001raf.1_Intron	NM_002336	NP_002327			low density lipoprotein receptor-related protein						cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)																---	---	---	---
Unknown	0	broad.mit.edu	37	12	15956516	15956516	+	IGR	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:15956516delG								EPS8 (14006 upstream) : STRAP (78772 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	12	20096042	20096042	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:20096042delA								AEBP2 (420869 upstream) : PDE3A (426155 downstream)																																			---	---	---	---
KIAA0528	9847	broad.mit.edu	37	12	22637469	22637469	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22637469delT	uc001rfq.2	-						KIAA0528_uc010sir.1_Intron|KIAA0528_uc010sis.1_Intron|KIAA0528_uc010sit.1_Intron|KIAA0528_uc010siu.1_Intron|KIAA0528_uc001rfr.2_Intron|KIAA0528_uc009ziy.1_Intron	NM_014802	NP_055617			hypothetical protein LOC9847								protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
TM7SF3	51768	broad.mit.edu	37	12	27152717	27152718	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27152717_27152718delAA	uc010sjl.1	-							NM_016551	NP_057635			transmembrane 7 superfamily member 3 precursor							integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)																	---	---	---	---
FGD4	121512	broad.mit.edu	37	12	32755058	32755058	+	Intron	DEL	T	-	-	rs4931641	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:32755058delT	uc001rkz.2	+						FGD4_uc001rlc.2_Intron|FGD4_uc001rky.2_Intron|FGD4_uc001rla.2_Intron|FGD4_uc010ske.1_Intron|FGD4_uc001rlb.1_Intron	NM_139241	NP_640334			FYVE, RhoGEF and PH domain containing 4						actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)																	---	---	---	---
GXYLT1	283464	broad.mit.edu	37	12	42481468	42481468	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:42481468delA	uc001rms.3	-	8					GXYLT1_uc001rmt.3_3'UTR	NM_173601	NP_775872			glycosyltransferase 8 domain containing 3						O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0																		---	---	---	---
ADAMTS20	80070	broad.mit.edu	37	12	43820982	43820983	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:43820982_43820983insA	uc010skx.1	-						ADAMTS20_uc001rno.1_Intron	NM_025003	NP_079279			a disintegrin-like and metalloprotease with							proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)														---	---	---	---
SLC38A4	55089	broad.mit.edu	37	12	47170830	47170830	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:47170830delA	uc001rpi.2	-						SLC38A4_uc001rpj.2_Intron	NM_018018	NP_060488			solute carrier family 38, member 4						cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)																	---	---	---	---
RPAP3	79657	broad.mit.edu	37	12	48063693	48063693	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48063693delA	uc001rpr.2	-						RPAP3_uc010slk.1_Intron|RPAP3_uc001rps.2_Intron	NM_024604	NP_078880			RNA polymerase II associated protein 3 isoform								binding			ovary(1)	1	Lung SC(27;0.192)																	---	---	---	---
RPAP3	79657	broad.mit.edu	37	12	48073181	48073182	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48073181_48073182delAA	uc001rpr.2	-						RPAP3_uc010slk.1_Intron|RPAP3_uc001rps.2_Intron	NM_024604	NP_078880			RNA polymerase II associated protein 3 isoform								binding			ovary(1)	1	Lung SC(27;0.192)																	---	---	---	---
RPAP3	79657	broad.mit.edu	37	12	48095064	48095064	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48095064delA	uc001rpr.2	-						RPAP3_uc010slk.1_Intron|RPAP3_uc001rps.2_Intron	NM_024604	NP_078880			RNA polymerase II associated protein 3 isoform								binding			ovary(1)	1	Lung SC(27;0.192)																	---	---	---	---
LMBR1L	55716	broad.mit.edu	37	12	49494516	49494516	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49494516delT	uc001rth.3	-						LMBR1L_uc001rtg.3_Intron|LMBR1L_uc001rti.3_Intron	NM_018113	NP_060583			lipocalin-interacting membrane receptor						endocytosis	integral to membrane|plasma membrane	receptor activity			pancreas(1)	1																		---	---	---	---
DCD	117159	broad.mit.edu	37	12	55038760	55038760	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55038760delA	uc001sgj.2	-						DCD_uc009znt.2_Intron|DCD_uc009znu.2_Intron	NM_053283	NP_444513			dermcidin preproprotein						defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			ovary(1)	1		Myeloproliferative disorder(1001;0.0255)																---	---	---	---
TIMELESS	8914	broad.mit.edu	37	12	56824461	56824461	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56824461delT	uc001slf.2	-						TIMELESS_uc001slg.2_Intron	NM_003920	NP_003911			timeless homolog						cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8																		---	---	---	---
PIP4K2C	79837	broad.mit.edu	37	12	57988779	57988779	+	Intron	DEL	A	-	-	rs146472729	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57988779delA	uc001sou.2	+						PIP4K2C_uc001sot.2_Intron|PIP4K2C_uc010srs.1_Intron|PIP4K2C_uc010srt.1_Intron	NM_001146258	NP_001139730			phosphatidylinositol-5-phosphate 4-kinase, type							cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)																	---	---	---	---
GNS	2799	broad.mit.edu	37	12	65130629	65130629	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:65130629delA	uc001ssg.3	-						GNS_uc001ssf.2_Intron|GNS_uc010ssq.1_Intron|GNS_uc010ssr.1_Intron	NM_002076	NP_002067			glucosamine (N-acetyl)-6-sulfatase precursor							lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)														---	---	---	---
RAP1B	5908	broad.mit.edu	37	12	69036118	69036118	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69036118delA	uc001sub.2	+						RAP1B_uc010ste.1_Intron|RAP1B_uc001suc.2_Intron|RAP1B_uc010stf.1_Intron|RAP1B_uc010stg.1_Intron|RAP1B_uc010sth.1_Intron|RAP1B_uc010sti.1_Intron	NM_001089704	NP_001083173			SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;						blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)														---	---	---	---
LYZ	4069	broad.mit.edu	37	12	69746146	69746146	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69746146delT	uc001suw.2	+							NM_000239	NP_000230			lysozyme precursor						cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding				0	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)															---	---	---	---
ZFC3H1	196441	broad.mit.edu	37	12	72021721	72021721	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:72021721delA	uc001swo.2	-							NM_144982	NP_659419			proline/serine-rich coiled-coil 2						RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
RAB21	23011	broad.mit.edu	37	12	72179669	72179670	+	3'UTR	INS	-	T	T	rs12320799		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:72179669_72179670insT	uc001swt.2	+	7						NM_014999	NP_055814			RAB21, member RAS oncogene family						protein transport|small GTPase mediated signal transduction	cleavage furrow|cytoplasmic vesicle membrane|early endosome membrane|endoplasmic reticulum membrane|Golgi membrane	GDP binding|GTP binding|GTPase activity|protein binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	77151861	77151862	+	IGR	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:77151861_77151862delAA								OSBPL8 (198272 upstream) : ZDHHC17 (5992 downstream)																																			---	---	---	---
PAWR	5074	broad.mit.edu	37	12	79988067	79988067	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:79988067delA	uc001syx.2	-							NM_002583	NP_002574			PRKC, apoptosis, WT1, regulator						actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	88213549	88213549	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88213549delA								MGAT4C (980868 upstream) : C12orf50 (160267 downstream)																																			---	---	---	---
C12orf29	91298	broad.mit.edu	37	12	88441883	88441884	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88441883_88441884delAA	uc001tao.2	+						C12orf29_uc001tap.2_Intron|C12orf29_uc009zsk.2_Intron	NM_001009894	NP_001009894			hypothetical protein LOC91298												0																		---	---	---	---
TMTC3	160418	broad.mit.edu	37	12	88568212	88568212	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88568212delT	uc001tau.2	+						TMTC3_uc009zsm.2_Intron	NM_181783	NP_861448			transmembrane and tetratricopeptide repeat							integral to membrane	binding			skin(1)	1																		---	---	---	---
CCDC38	120935	broad.mit.edu	37	12	96284755	96284755	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96284755delA	uc001tek.1	-							NM_182496	NP_872302			coiled-coil domain containing 38											skin(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	98073980	98073980	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:98073980delA								RMST (115187 upstream) : LOC100128191 (832773 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	12	100402758	100402758	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100402758delT								ANKS1B (24326 upstream) : UHRF1BP1L (28107 downstream)																																			---	---	---	---
FICD	11153	broad.mit.edu	37	12	108913293	108913293	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:108913293delA	uc001tmx.1	+	3						NM_007076	NP_009007			Huntingtin interacting protein E						negative regulation of Rho GTPase activity	integral to membrane	binding|protein adenylyltransferase activity				0																		---	---	---	---
TCTN1	79600	broad.mit.edu	37	12	111079898	111079898	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111079898delT	uc009zvs.2	+						TCTN1_uc001trp.3_Intron|TCTN1_uc001trn.3_Intron|TCTN1_uc001trk.3_Intron|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006			tectonic family member 1 isoform 2						multicellular organismal development	extracellular region					0																		---	---	---	---
MSI1	4440	broad.mit.edu	37	12	120809497	120809498	+	5'Flank	DEL	AA	-	-	rs112962110		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120809497_120809498delAA	uc001tye.1	-							NM_002442	NP_002433			musashi 1						nervous system development	cytoplasm|nucleus	nucleotide binding			central_nervous_system(2)|breast(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
RNF34	80196	broad.mit.edu	37	12	121840361	121840361	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121840361delA	uc001ual.1	+						RNF34_uc010szw.1_Intron|RNF34_uc001uak.1_Intron|RNF34_uc001uam.1_Intron	NM_025126	NP_079402			ring finger protein 34 isoform 2						apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)														---	---	---	---
SETD8	387893	broad.mit.edu	37	12	123889740	123889740	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123889740delT	uc001uew.2	+						SETD8_uc001uex.2_Intron	NM_020382	NP_065115			SET domain-containing 8						cell division|mitosis|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding|transcription corepressor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.00101)|Epithelial(86;0.00425)														---	---	---	---
NCOR2	9612	broad.mit.edu	37	12	124820270	124820270	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124820270delG	uc010tay.1	-						NCOR2_uc010taz.1_Intron|NCOR2_uc010tax.1_Intron	NM_006312	NP_006303			nuclear receptor co-repressor 2 isoform 1						cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)														---	---	---	---
BRI3BP	140707	broad.mit.edu	37	12	125510040	125510040	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:125510040delA	uc001uha.1	+	3						NM_080626	NP_542193			BRI3-binding protein							integral to membrane|mitochondrial outer membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.35e-05)|Epithelial(86;0.000426)|all cancers(50;0.00576)														---	---	---	---
MTMR6	9107	broad.mit.edu	37	13	25836009	25836009	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25836009delA	uc001uqf.3	-						MTMR6_uc001uqe.1_Intron	NM_004685	NP_004676			myotubularin related protein 6							cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)														---	---	---	---
CDX2	1045	broad.mit.edu	37	13	28538846	28538854	+	Intron	DEL	AAAAAAAAA	-	-	rs66744020		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28538846_28538854delAAAAAAAAA	uc001urv.2	-							NM_001265	NP_001256			caudal type homeobox 2						organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)	1	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)				T	ETV6	AML								---	---	---	---
PAN3	255967	broad.mit.edu	37	13	28790241	28790242	+	Intron	INS	-	TTAAG	TTAAG	rs144982471	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28790241_28790242insTTAAG	uc001urz.2	+						PAN3_uc010tdo.1_Intron|PAN3_uc001ury.2_Intron|PAN3_uc001urx.2_Intron	NM_175854	NP_787050			PABP1-dependent poly A-specific ribonuclease						nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)														---	---	---	---
NBEA	26960	broad.mit.edu	37	13	36202145	36202145	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:36202145delA	uc001uvb.2	+						NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_Intron|NBEA_uc010teg.1_Intron|NBEA_uc001uvd.2_Intron	NM_015678	NP_056493			neurobeachin							cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)														---	---	---	---
MTRF1	9617	broad.mit.edu	37	13	41834495	41834495	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41834495delA	uc001uxx.2	-						MTRF1_uc001uxy.2_Intron|MTRF1_uc001uxz.2_Intron|MTRF1_uc010tff.1_Intron|MTRF1_uc001uyc.1_Intron	NM_004294	NP_004285			mitochondrial translational release factor 1						regulation of translational termination	mitochondrion	translation release factor activity, codon specific				0		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	48340720	48340723	+	IGR	DEL	TTTT	-	-	rs112736233		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:48340720_48340723delTTTT								HTR2A (869670 upstream) : SUCLA2 (176069 downstream)																																			---	---	---	---
PHF11	51131	broad.mit.edu	37	13	50094900	50094900	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:50094900delA	uc001vdb.2	+						PHF11_uc001vdc.2_Intron|PHF11_uc001vdd.2_Intron	NM_001040443	NP_001035533			PHD finger protein 11 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.38e-09)														---	---	---	---
TDRD3	81550	broad.mit.edu	37	13	61057789	61057789	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:61057789delT	uc001via.2	+						TDRD3_uc010aef.2_Intron|TDRD3_uc001vhz.3_Intron|TDRD3_uc010aeg.2_Intron|TDRD3_uc001vib.3_Intron	NM_030794	NP_110421			tudor domain containing 3 isoform 2						chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)														---	---	---	---
TBC1D4	9882	broad.mit.edu	37	13	75894317	75894317	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:75894317delT	uc001vjl.1	-						TBC1D4_uc010aer.2_Intron|TBC1D4_uc010aes.2_Intron	NM_014832	NP_055647			TBC1 domain family, member 4							cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	88542299	88542299	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:88542299delT								SLITRK5 (210431 upstream) : None (None downstream)																																			---	---	---	---
UGGT2	55757	broad.mit.edu	37	13	96512945	96512945	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:96512945delT	uc001vmt.2	-							NM_020121	NP_064506			UDP-glucose ceramide glucosyltransferase-like 2						post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
STK24	8428	broad.mit.edu	37	13	99134321	99134325	+	Intron	DEL	AAAAA	-	-	rs34520150		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99134321_99134325delAAAAA	uc001vnm.1	-						STK24_uc001vnn.1_Intron|STK24_uc010tim.1_Intron	NM_003576	NP_003567			serine/threonine kinase 24 isoform a						cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)															---	---	---	---
DOCK9	23348	broad.mit.edu	37	13	99540398	99540399	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99540398_99540399delAA	uc001vnt.2	-						DOCK9_uc001vnw.2_Intron|DOCK9_uc001vnv.1_Intron|DOCK9_uc010tir.1_Intron|DOCK9_uc010tis.1_Intron|DOCK9_uc010tit.1_Intron|DOCK9_uc010afu.1_Intron	NM_015296	NP_056111			dedicator of cytokinesis 9 isoform a						blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
ANKRD10	55608	broad.mit.edu	37	13	111536253	111536253	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:111536253delA	uc001vrn.2	-						ANKRD10_uc001vrm.2_Intron|ANKRD10_uc001vrl.2_5'Flank	NM_017664	NP_060134			ankyrin repeat domain 10											central_nervous_system(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)															---	---	---	---
TUBGCP3	10426	broad.mit.edu	37	13	113202191	113202191	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113202191delA	uc001vse.1	-						TUBGCP3_uc010tjq.1_Intron|TUBGCP3_uc001vsf.2_Intron|TUBGCP3_uc001vsg.1_Intron	NM_006322	NP_006313			tubulin, gamma complex associated protein 3						G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)																	---	---	---	---
CDC16	8881	broad.mit.edu	37	13	115004335	115004335	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:115004335delT	uc001vuk.1	+						CDC16_uc010tkm.1_Intron|CDC16_uc001vul.1_Intron|CDC16_uc001vum.1_Intron|CDC16_uc001vun.1_Intron|CDC16_uc001vuo.1_Intron	NM_003903	NP_003894			anaphase-promoting complex, subunit 6						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding				0	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)															---	---	---	---
Unknown	0	broad.mit.edu	37	14	19339542	19339542	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:19339542delA								None (None upstream) : OR11H12 (38052 downstream)																																			---	---	---	---
CCNB1IP1	57820	broad.mit.edu	37	14	20779552	20779552	+	3'UTR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20779552delT	uc001vwv.2	-	7					CCNB1IP1_uc001vww.2_3'UTR|CCNB1IP1_uc001vwx.2_3'UTR|CCNB1IP1_uc001vwy.2_3'UTR|CCNB1IP1_uc001vwz.2_3'UTR	NM_182851	NP_878271			cyclin B1 interacting protein 1 isoform 3							chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	soft_tissue(2)|ovary(1)	3	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)				T	HMGA2	leiomyoma								---	---	---	---
METT11D1	64745	broad.mit.edu	37	14	21460882	21460882	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21460882delT	uc001vyn.2	+						METT11D1_uc010tlk.1_3'UTR|METT11D1_uc001vym.2_Intron|METT11D1_uc001vyo.2_Intron|METT11D1_uc001vyp.2_Intron|METT11D1_uc001vyq.2_Intron	NM_022734	NP_073571			methyltransferase 11 domain containing 1 isoform						translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22749756	22749756	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22749756delA	uc001wbw.2	+						uc010aja.1_Intron|uc010tmk.1_Intron|uc010tmo.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc010ajg.1_Intron|uc001wcx.3_Intron|uc001wdd.2_Intron|uc010ajj.1_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Intron|uc001wdg.1_Intron|uc010ajl.1_Intron|uc001wdj.2_Intron|uc010ajo.1_Intron|uc010ajp.1_Intron					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22979834	22979835	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22979834_22979835delAA	uc001wbw.2	+						uc010aja.1_Intron|uc010tmk.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc001wcx.3_Intron|uc010ajj.1_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Intron|uc001wdg.1_Intron|uc010ajl.1_Intron|uc001wdj.2_Intron|uc010ajo.1_Intron|uc010ajp.1_Intron|uc001wdv.3_Intron|uc001wec.2_Intron|uc001wee.3_Intron|uc010tmt.1_Intron|uc010ajv.1_Intron|uc001weg.2_Intron|uc001weh.1_Intron|uc001wei.2_Intron|uc001wej.2_Intron|uc001wek.2_Intron|uc001wel.2_Intron|uc001wem.3_Intron|uc001wen.1_Intron|uc001weo.2_Intron|uc001wep.2_Intron|uc001weq.2_Intron|uc001wer.2_Intron|uc001wet.2_Intron|uc001weu.2_Intron|uc001wev.2_Intron|uc001wew.2_Intron|uc010tmv.1_Intron|uc001wez.2_Intron|uc010ajx.1_Intron|uc001wfb.1_Intron|uc001wfd.1_Intron|uc001wfe.2_Intron|uc001wfg.2_Intron|uc001wfh.1_5'Flank|uc001wfi.2_5'Flank					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
ACIN1	22985	broad.mit.edu	37	14	23550267	23550269	+	Intron	DEL	TTT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23550267_23550269delTTT	uc001wit.3	-						ACIN1_uc001wis.3_5'Flank|ACIN1_uc010akg.2_Intron|ACIN1_uc010tnj.1_Intron	NM_014977	NP_055792			apoptotic chromatin condensation inducer 1						apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)														---	---	---	---
THTPA	79178	broad.mit.edu	37	14	24027717	24027717	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24027717delT	uc001wkh.3	+						THTPA_uc001wkb.3_Intron|THTPA_uc001wkg.3_Intron|THTPA_uc010akr.2_Intron|THTPA_uc001wki.3_Intron|uc001wko.1_5'Flank	NM_001126339	NP_001119811			thiamine triphosphatase						dephosphorylation|generation of precursor metabolites and energy|thiamine metabolic process	cytosol|nucleolus|soluble fraction	thiamin-triphosphatase activity				0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00643)	Thiamine(DB00152)													---	---	---	---
SOS2	6655	broad.mit.edu	37	14	50670810	50670810	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50670810delT	uc001wxs.3	-						SOS2_uc010tql.1_Intron	NM_006939	NP_008870			son of sevenless homolog 2						apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)																	---	---	---	---
PSMC6	5706	broad.mit.edu	37	14	53178422	53178422	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:53178422delT	uc010tqx.1	+						PSMC6_uc010tqw.1_Intron	NM_002806	NP_002797			proteasome 26S ATPase subunit 6						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			lung(1)	1	Breast(41;0.176)																	---	---	---	---
STYX	6815	broad.mit.edu	37	14	53235543	53235545	+	Intron	DEL	TTA	-	-	rs2274274	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:53235543_53235545delTTA	uc010tqy.1	+						STYX_uc001xaa.2_Intron	NM_001130701	NP_001124173			serine/threonine/tyrosine interacting protein						protein dephosphorylation|spermatogenesis	cytoplasm	protein tyrosine/serine/threonine phosphatase activity				0	Breast(41;0.176)																	---	---	---	---
GMFB	2764	broad.mit.edu	37	14	54944919	54944919	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:54944919delA	uc010tqz.1	-						GMFB_uc001xaw.1_Intron	NM_004124	NP_004115			glia maturation factor, beta						nervous system development|protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity|signal transducer activity				0																		---	---	---	---
ATP6V1D	51382	broad.mit.edu	37	14	67809927	67809927	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:67809927delT	uc001xjf.2	-						ATP6V1D_uc001xje.2_Intron	NM_015994	NP_057078			H(+)-transporting two-sector ATPase						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain|vacuolar proton-transporting V-type ATPase complex	protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)|lung(1)	2				all cancers(60;0.000739)|OV - Ovarian serous cystadenocarcinoma(108;0.00597)|BRCA - Breast invasive adenocarcinoma(234;0.00957)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	68079851	68079851	+	IGR	DEL	T	-	-	rs35284636		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:68079851delT								PIGH (12834 upstream) : ARG2 (6728 downstream)																																			---	---	---	---
GALNTL1	57452	broad.mit.edu	37	14	69787233	69787233	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:69787233delA	uc010aqu.1	+						GALNTL1_uc001xla.1_Intron|GALNTL1_uc001xlb.1_Intron	NM_020692	NP_065743			UDP-N-acetyl-alpha-D-galactosamine:polypeptide							Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)														---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	79434392	79434399	+	Intron	DEL	CCCCCCCC	-	-	rs148023649		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:79434392_79434399delCCCCCCCC	uc001xun.2	+						NRXN3_uc001xum.1_Intron|NRXN3_uc010asv.1_Intron	NM_004796	NP_004787			neurexin 3 isoform 1 precursor						axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
ZC3H14	79882	broad.mit.edu	37	14	89075977	89075977	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:89075977delA	uc001xww.2	+						ZC3H14_uc010twd.1_Intron|ZC3H14_uc010twe.1_Intron|ZC3H14_uc001xwx.2_Intron|ZC3H14_uc010twf.1_Intron|ZC3H14_uc001xwy.2_Intron|ZC3H14_uc010twg.1_Intron|ZC3H14_uc001xxa.2_Intron|ZC3H14_uc001xxc.2_Intron|ZC3H14_uc001xxb.2_Intron	NM_024824	NP_079100			zinc finger CCCH-type containing 14 isoform 1							cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
CPSF2	53981	broad.mit.edu	37	14	92604781	92604781	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92604781delT	uc001yah.1	+							NM_017437	NP_059133			cleavage and polyadenylation specific factor 2						histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)														---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	94079648	94079649	+	Intron	DEL	GT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94079648_94079649delGT	uc001ybv.1	+						KIAA1409_uc001ybs.1_Intron	NM_020818	NP_065869			hypothetical protein LOC57578							integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106993572	106993572	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106993572delA	uc010tyt.1	-											Parts of antibodies, mostly variable regions.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	22646862	22646862	+	IGR	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22646862delC								MIR1268 (133582 upstream) : GOLGA8DP (55423 downstream)																																			---	---	---	---
TJP1	7082	broad.mit.edu	37	15	30022801	30022802	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:30022801_30022802delAA	uc001zcr.2	-						TJP1_uc010azl.2_Intron|TJP1_uc001zcq.2_Intron|TJP1_uc001zcs.2_Intron	NM_003257	NP_003248			tight junction protein 1 isoform a						cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	34157542	34157542	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34157542delA	uc001zhi.2	+	104					RYR3_uc010bar.2_3'UTR	NM_001036	NP_001027			ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
Unknown	0	broad.mit.edu	37	15	41026744	41026744	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41026744delA								RAD51 (2390 upstream) : FAM82A2 (1342 downstream)																																			---	---	---	---
UBR1	197131	broad.mit.edu	37	15	43324947	43324947	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43324947delT	uc001zqq.2	-						UBR1_uc010udk.1_Intron	NM_174916	NP_777576			ubiquitin protein ligase E3 component n-recognin						cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)														---	---	---	---
TP53BP1	7158	broad.mit.edu	37	15	43761962	43761962	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43761962delA	uc001zrs.2	-						TP53BP1_uc010udp.1_Intron|TP53BP1_uc001zrq.3_Intron|TP53BP1_uc001zrr.3_Intron|TP53BP1_uc010udq.1_Intron	NM_005657	NP_005648			tumor protein p53 binding protein 1 isoform 3						double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)									Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					---	---	---	---
SEMA6D	80031	broad.mit.edu	37	15	48058482	48058484	+	Intron	DEL	TTG	-	-	rs528882	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48058482_48058484delTTG	uc010bek.2	+						SEMA6D_uc001zvw.2_Intron|SEMA6D_uc001zvy.2_Intron|SEMA6D_uc001zvz.2_Intron|SEMA6D_uc001zwa.2_Intron|SEMA6D_uc001zwb.2_Intron|SEMA6D_uc001zwc.2_Intron	NM_153618	NP_705871			semaphorin 6D isoform 4 precursor						axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)														---	---	---	---
MYEF2	50804	broad.mit.edu	37	15	48449998	48449999	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48449998_48449999delAA	uc001zwi.3	-						MYEF2_uc001zwj.3_Intron|MYEF2_uc001zwl.2_Intron	NM_016132	NP_057216			myelin expression factor 2						transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)														---	---	---	---
CEP152	22995	broad.mit.edu	37	15	49059021	49059021	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49059021delA	uc001zwy.2	-						CEP152_uc001zwz.2_Intron|CEP152_uc001zxa.1_Intron	NM_014985	NP_055800			centrosomal protein 152kDa						centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)														---	---	---	---
CEP152	22995	broad.mit.edu	37	15	49097636	49097636	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49097636delT	uc001zwy.2	-						CEP152_uc001zwz.2_Intron|CEP152_uc001zxa.1_Intron	NM_014985	NP_055800			centrosomal protein 152kDa						centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)														---	---	---	---
C15orf33	196951	broad.mit.edu	37	15	49834081	49834081	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49834081delT	uc001zxl.2	-						C15orf33_uc001zxm.2_Intron	NM_152647	NP_689860			hypothetical protein LOC196951											ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)														---	---	---	---
KIAA1370	56204	broad.mit.edu	37	15	52893392	52893392	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52893392delA	uc002acg.3	-						KIAA1370_uc002ach.3_Intron|KIAA1370_uc010bfg.1_Intron|KIAA1370_uc010ugf.1_Intron	NM_019600	NP_062546			hypothetical protein LOC56204												0				all cancers(107;0.0803)														---	---	---	---
CCPG1	9236	broad.mit.edu	37	15	55723120	55723120	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55723120delT	uc002acy.2	-						DYX1C1_uc010ugh.1_Intron|DYX1C1_uc010ugi.1_Intron|DYX1C1_uc002adb.2_Intron|DYX1C1_uc002adc.2_Intron|DYX1C1_uc002add.2_Intron	NM_020739	NP_065790			cell cycle progression 1 isoform 2						cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)														---	---	---	---
SLTM	79811	broad.mit.edu	37	15	59192258	59192261	+	Intron	DEL	AAAA	-	-	rs35822874		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59192258_59192261delAAAA	uc002afp.2	-						SLTM_uc002afo.2_Intron|SLTM_uc002afq.2_Intron|SLTM_uc010bgd.2_Intron|SLTM_uc002afr.1_Intron	NM_024755	NP_079031			modulator of estrogen induced transcription						apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1																		---	---	---	---
PDCD7	10081	broad.mit.edu	37	15	65411613	65411613	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65411613delA	uc002aol.2	-							NM_005707	NP_005698			programmed cell death 7						apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex					0																		---	---	---	---
MAP2K5	5607	broad.mit.edu	37	15	67920817	67920817	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:67920817delA	uc002aqu.2	+						MAP2K5_uc002aqt.1_Intron|MAP2K5_uc002aqv.2_Intron|MAP2K5_uc002aqw.2_Intron	NM_145160	NP_660143			mitogen-activated protein kinase kinase 5						nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)	2																		---	---	---	---
HIGD2B	123346	broad.mit.edu	37	15	72968749	72968751	+	Intron	DEL	TTT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72968749_72968751delTTT	uc002ava.2	-							NR_002780				Homo sapiens HIG1 domain family, member 2B pseudogene, mRNA (cDNA clone IMAGE:5742106).												0																		---	---	---	---
ARID3B	10620	broad.mit.edu	37	15	74865018	74865018	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74865018delA	uc002aye.2	+						ARID3B_uc002ayc.2_Intron|ARID3B_uc002ayd.2_Intron	NM_006465	NP_006456			AT rich interactive domain 3B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0																		---	---	---	---
SIN3A	25942	broad.mit.edu	37	15	75706706	75706706	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75706706delA	uc002bai.2	-						SIN3A_uc002baj.2_Intron|SIN3A_uc010uml.1_Intron	NM_015477	NP_056292			transcriptional co-repressor Sin3A						blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5																		---	---	---	---
CRABP1	1381	broad.mit.edu	37	15	78640105	78640105	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78640105delA	uc002bdp.2	+							NM_004378	NP_004369			cellular retinoic acid binding protein 1						multicellular organismal development|signal transduction	cytoplasm	retinal binding|retinol binding|transporter activity				0					Alitretinoin(DB00523)|Etretinate(DB00926)													---	---	---	---
Unknown	0	broad.mit.edu	37	15	79021116	79021116	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79021116delT								CHRNB4 (68242 upstream) : ADAMTS7 (30430 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	15	79026913	79026913	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79026913delT								CHRNB4 (74039 upstream) : ADAMTS7 (24633 downstream)																																			---	---	---	---
ADAMTS7	11173	broad.mit.edu	37	15	79051927	79051928	+	Intron	INS	-	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79051927_79051928insG	uc002bej.3	-							NM_014272	NP_055087			ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0																		---	---	---	---
ADAMTSL3	57188	broad.mit.edu	37	15	84561733	84561733	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:84561733delA	uc002bjz.3	+						ADAMTSL3_uc010bmt.1_Intron|ADAMTSL3_uc010bmu.1_Intron	NM_207517	NP_997400			ADAMTS-like 3 precursor							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)															---	---	---	---
ADAMTSL3	57188	broad.mit.edu	37	15	84651007	84651007	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:84651007delT	uc002bjz.3	+						ADAMTSL3_uc010bmt.1_Intron|ADAMTSL3_uc010bmu.1_Intron	NM_207517	NP_997400			ADAMTS-like 3 precursor							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)															---	---	---	---
SLCO3A1	28232	broad.mit.edu	37	15	92706441	92706441	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:92706441delA	uc002bqx.2	+	10					SLCO3A1_uc002bqy.2_Intron	NM_013272	NP_037404			solute carrier organic anion transporter family,						sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)															---	---	---	---
Unknown	0	broad.mit.edu	37	15	102299886	102299887	+	5'Flank	INS	-	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:102299886_102299887insG	uc002bzh.1	-						uc002bzk.2_5'Flank|uc002bzn.2_5'Flank|uc010uso.1_5'Flank|uc002bzs.2_5'Flank|uc010usv.1_5'Flank|uc002cal.2_5'Flank|uc002cam.2_5'Flank|uc010usx.1_5'Flank|uc002cao.2_5'Flank|uc002cap.2_5'Flank|uc002caq.2_5'Flank|uc010usz.1_5'Flank|uc010uta.1_5'Flank|uc002cas.2_5'Flank|uc002cat.1_5'Flank|uc002cau.2_5'Flank|uc010utb.1_5'Flank|uc002cav.2_5'Flank|uc002caw.2_5'Flank|uc002cax.2_5'Flank|uc010utc.1_5'Flank|uc002cay.2_5'Flank|uc002cbb.2_5'Flank|uc002cbc.1_5'Flank|uc002cbd.2_5'Flank|uc002cbe.2_5'Flank|uc002cbg.2_5'Flank|uc002cbh.2_5'Flank|uc002cbi.2_5'Flank|uc002cbk.2_5'Flank|uc002cbl.2_5'Flank|uc010utd.1_5'Flank					DQ575740																														---	---	---	---
LUC7L	55692	broad.mit.edu	37	16	258008	258008	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:258008delA	uc002cgc.1	-						LUC7L_uc002cga.1_Intron|LUC7L_uc002cgd.1_Intron|LUC7L_uc002cge.1_Intron|LUC7L_uc002cgb.1_Intron	NM_201412	NP_958815			LUC7-like isoform b								metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)																---	---	---	---
SLC9A3R2	9351	broad.mit.edu	37	16	2087453	2087453	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2087453delG	uc002coi.2	+						SLC9A3R2_uc002coj.2_Intron|SLC9A3R2_uc002cok.2_Intron	NM_001130012	NP_001123484			solute carrier family 9 isoform 3 regulator 2						protein complex assembly	apical plasma membrane|endomembrane system|nucleus	beta-catenin binding|phosphatase binding|protein C-terminus binding|receptor binding			central_nervous_system(1)	1																		---	---	---	---
TRAF7	84231	broad.mit.edu	37	16	2223873	2223873	+	Intron	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2223873delC	uc002cow.2	+							NM_032271	NP_115647			TNF receptor-associated factor 7						activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3																		---	---	---	---
SRL	6345	broad.mit.edu	37	16	4247598	4247598	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4247598delT	uc002cvz.3	-						SRL_uc002cvy.3_Intron	NM_001098814	NP_001092284			sarcalumenin							sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5																		---	---	---	---
USP7	7874	broad.mit.edu	37	16	8994680	8994681	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:8994680_8994681delAA	uc002czl.2	-						USP7_uc010uyk.1_Intron|USP7_uc002czj.2_Intron|USP7_uc010uyj.1_Intron|USP7_uc002czk.2_Intron	NM_003470	NP_003461			ubiquitin specific peptidase 7						interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3																		---	---	---	---
TEKT5	146279	broad.mit.edu	37	16	10776187	10776188	+	Intron	INS	-	T	T	rs142893480	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:10776187_10776188insT	uc002czz.1	-							NM_144674	NP_653275			tektin 5						microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	12936326	12936326	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:12936326delT								CPPED1 (38582 upstream) : SHISA9 (59151 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	16	18027200	18027200	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18027200delA								XYLT1 (462462 upstream) : NOMO2 (483983 downstream)																																			---	---	---	---
SMG1	23049	broad.mit.edu	37	16	18883764	18883764	+	Intron	DEL	A	-	-	rs117332168	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18883764delA	uc002dfm.2	-						SMG1_uc010bwb.2_Intron	NM_015092	NP_055907			PI-3-kinase-related kinase SMG-1						DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16																		---	---	---	---
GDE1	51573	broad.mit.edu	37	16	19516621	19516621	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19516621delT	uc002dgh.2	-						GDE1_uc002dgi.2_Intron	NM_016641	NP_057725			glycerophosphodiester phosphodiesterase 1						glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol glycerophosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
IQCK	124152	broad.mit.edu	37	16	19799955	19799955	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19799955delT	uc002dgr.2	+						IQCK_uc002dgs.2_Intron|IQCK_uc010vat.1_Intron|IQCK_uc010bwc.2_Intron|IQCK_uc010vau.1_Intron	NM_153208	NP_694940			IQ motif containing K											skin(1)	1																		---	---	---	---
GTF3C1	2975	broad.mit.edu	37	16	27509762	27509762	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27509762delT	uc002dov.1	-						GTF3C1_uc002dou.2_Intron	NM_001520	NP_001511			general transcription factor IIIC, polypeptide							transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5																		---	---	---	---
LOC595101	595101	broad.mit.edu	37	16	30291742	30291742	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30291742delA	uc002dxp.1	-							NR_002453				Homo sapiens cDNA FLJ39663 fis, clone SMINT2007187.												0																		---	---	---	---
ARMC5	79798	broad.mit.edu	37	16	31475614	31475624	+	Intron	DEL	AAAAAAAAAAA	-	-	rs10712732		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31475614_31475624delAAAAAAAAAAA	uc002ecc.2	+						ARMC5_uc010vfn.1_Intron|ARMC5_uc010vfo.1_Intron|ARMC5_uc002eca.3_Intron|ARMC5_uc010vfp.1_Intron|ARMC5_uc002ecb.2_Intron	NM_001105247	NP_001098717			armadillo repeat containing 5 isoform a								binding			pancreas(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	35037168	35037168	+	5'Flank	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:35037168delA	uc002eea.2	-											full-length cDNA clone CS0DL003YH09 of B cells (Ramos cell line) Cot 25-normalized of Homo sapiens (human).																														---	---	---	---
ITFG1	81533	broad.mit.edu	37	16	47292700	47292700	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47292700delA	uc002eet.2	-						ITFG1_uc010vgg.1_Intron|ITFG1_uc010vgh.1_Intron	NM_030790	NP_110417			integrin alpha FG-GAP repeat containing 1							extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)																---	---	---	---
SALL1	6299	broad.mit.edu	37	16	51185193	51185193	+	5'Flank	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:51185193delA	uc010vgs.1	-						SALL1_uc010vgr.1_5'Flank|SALL1_uc010cbv.2_5'Flank	NM_002968	NP_002959			sal-like 1 isoform a						adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)															---	---	---	---
CHD9	80205	broad.mit.edu	37	16	53326632	53326632	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53326632delT	uc002ehb.2	+						CHD9_uc002egy.2_Intron|CHD9_uc002ehc.2_Intron|CHD9_uc002ehf.2_Intron|CHD9_uc010cbw.2_Intron	NM_025134	NP_079410			chromodomain helicase DNA binding protein 9						cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)																---	---	---	---
FAM192A	80011	broad.mit.edu	37	16	57206385	57206385	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57206385delA	uc010vhk.1	-						FAM192A_uc002ekz.3_Intron|FAM192A_uc002ekv.3_Intron|FAM192A_uc002ekw.3_Intron|FAM192A_uc002ekx.3_Intron|FAM192A_uc002eky.3_Intron|FAM192A_uc010ccx.2_Intron	NM_024946	NP_079222			NEFA-interacting nuclear protein NIP30							nucleus					0																		---	---	---	---
FAM192A	80011	broad.mit.edu	37	16	57206437	57206437	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57206437delA	uc010vhk.1	-						FAM192A_uc002ekz.3_Intron|FAM192A_uc002ekv.3_Intron|FAM192A_uc002ekw.3_Intron|FAM192A_uc002ekx.3_Intron|FAM192A_uc002eky.3_Intron|FAM192A_uc010ccx.2_Intron	NM_024946	NP_079222			NEFA-interacting nuclear protein NIP30							nucleus					0																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	69209573	69209573	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69209573delA								CIRH1A (6637 upstream) : SNTB2 (11477 downstream)																																			---	---	---	---
HYDIN	54768	broad.mit.edu	37	16	70871522	70871522	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70871522delG	uc002ezr.2	-						HYDIN_uc010cfy.2_Intron	NM_032821	NP_116210			hydrocephalus inducing isoform a											ovary(1)|skin(1)	2		Ovarian(137;0.0654)																---	---	---	---
MLKL	197259	broad.mit.edu	37	16	74719239	74719239	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:74719239delA	uc002fdb.2	-						MLKL_uc002fdc.2_Intron	NM_152649	NP_689862			mixed lineage kinase domain-like isoform 1								ATP binding|protein binding|protein kinase activity			stomach(2)	2																		---	---	---	---
PKD1L2	114780	broad.mit.edu	37	16	81155068	81155069	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81155068_81155069insA	uc002fgh.1	-						PKD1L2_uc002fgf.1_Intron|PKD1L2_uc002fgg.1_Intron	NM_052892	NP_443124			polycystin 1-like 2 isoform a						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
CDH13	1012	broad.mit.edu	37	16	83159141	83159141	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:83159141delT	uc002fgx.2	+						CDH13_uc010chh.2_Intron|CDH13_uc010vns.1_Intron|CDH13_uc010vnt.1_Intron|CDH13_uc010vnu.1_Intron	NM_001257	NP_001248			cadherin 13 preproprotein						adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)														---	---	---	---
MBTPS1	8720	broad.mit.edu	37	16	84094451	84094452	+	Intron	DEL	TT	-	-	rs71920773		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84094451_84094452delTT	uc002fhi.2	-						MBTPS1_uc002fhh.2_Intron	NM_003791	NP_003782			membrane-bound transcription factor site-1						cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2																		---	---	---	---
CPNE7	27132	broad.mit.edu	37	16	89662149	89662149	+	Intron	DEL	C	-	-	rs80012305	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89662149delC	uc002fnp.2	+						CPNE7_uc002fnq.2_Intron	NM_014427	NP_055242			copine 7 isoform b						lipid metabolic process		transporter activity				0		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)														---	---	---	---
SMTNL2	342527	broad.mit.edu	37	17	4510381	4510381	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4510381delA	uc002fyf.1	+						SMTNL2_uc002fye.2_Intron	NM_001114974	NP_001108446			smoothelin-like 2 isoform 1												0				READ - Rectum adenocarcinoma(115;0.0325)														---	---	---	---
C17orf61	254863	broad.mit.edu	37	17	7306339	7306339	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7306339delA	uc002ggs.2	-	4					PLSCR3_uc002ggr.1_Intron|PLSCR3_uc010cmg.1_Intron	NM_152766	NP_689979			hypothetical protein LOC254863 precursor							integral to membrane				ovary(1)	1		Prostate(122;0.173)																---	---	---	---
CCDC144B	284047	broad.mit.edu	37	17	18498258	18498258	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18498258delT	uc002gub.1	-						CCDC144B_uc002gua.3_Intron|CCDC144B_uc010vyc.1_Intron	NM_182568	NP_872374			coiled-coil domain containing 144B											ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	21163594	21163594	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:21163594delT								C17orf103 (7016 upstream) : MAP2K3 (24374 downstream)																																			---	---	---	---
PIGS	94005	broad.mit.edu	37	17	26890322	26890324	+	Intron	DEL	AAT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26890322_26890324delAAT	uc002hbo.2	-						PIGS_uc002hbn.2_Intron|PIGS_uc010wap.1_Intron	NM_033198	NP_149975			phosphatidylinositol glycan anchor biosynthesis,						attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)																	---	---	---	---
TAOK1	57551	broad.mit.edu	37	17	27794299	27794299	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27794299delT	uc002hdz.1	+						TAOK1_uc010wbe.1_Intron|TAOK1_uc010wbf.1_Intron	NM_020791	NP_065842			TAO kinase 1						mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)															---	---	---	---
NF1	4763	broad.mit.edu	37	17	29496739	29496739	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29496739delT	uc002hgg.2	+						NF1_uc002hge.1_Intron|NF1_uc002hgf.1_Intron|NF1_uc002hgh.2_Intron|NF1_uc010csn.1_Intron	NM_001042492	NP_001035957			neurofibromin isoform 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)				D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			---	---	---	---
RAB11FIP4	84440	broad.mit.edu	37	17	29848450	29848450	+	Intron	DEL	G	-	-	rs2301684	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29848450delG	uc002hgn.1	+						RAB11FIP4_uc002hgo.2_Intron	NM_032932	NP_116321			RAB11 family interacting protein 4 (class II)						cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)																---	---	---	---
CCT6B	10693	broad.mit.edu	37	17	33281346	33281346	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33281346delA	uc002hig.2	-						CCT6B_uc010ctg.2_Intron|CCT6B_uc010wcc.1_Intron	NM_006584	NP_006575			chaperonin containing TCP1, subunit 6B						chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)																---	---	---	---
ERBB2	2064	broad.mit.edu	37	17	37884438	37884441	+	3'UTR	DEL	CCTT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37884438_37884441delCCTT	uc002hso.2	+	27					ERBB2_uc002hsm.2_3'UTR|ERBB2_uc010cwa.2_3'UTR|ERBB2_uc002hsp.2_3'UTR|ERBB2_uc010cwb.2_3'UTR|ERBB2_uc010wek.1_3'UTR	NM_004448	NP_004439			erbB-2 isoform a						cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			---	---	---	---
KRTAP3-3	85293	broad.mit.edu	37	17	39149904	39149904	+	3'UTR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39149904delT	uc002hvr.1	-	1						NM_033185	NP_149441			keratin associated protein 3-3							keratin filament	structural molecule activity				0		Breast(137;0.00043)																---	---	---	---
MLX	6945	broad.mit.edu	37	17	40720380	40720380	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40720380delA	uc002iag.2	+						MLX_uc002iaf.2_Intron|MLX_uc002iah.2_Intron	NM_170607	NP_733752			transcription factor-like protein 4 isoform						energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)														---	---	---	---
DBF4B	80174	broad.mit.edu	37	17	42797080	42797080	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42797080delT	uc002ihf.2	+						DBF4B_uc002ihd.1_Intron|DBF4B_uc010wjb.1_Intron|DBF4B_uc002ihe.2_Intron|DBF4B_uc010wjc.1_Intron|DBF4B_uc002ihg.2_Intron	NM_145663	NP_663696			DBF4 homolog B isoform 1						cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)																---	---	---	---
NPEPPS	9520	broad.mit.edu	37	17	45696921	45696922	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45696921_45696922delAA	uc002ilr.3	+						NPEPPS_uc010wkt.1_Intron|NPEPPS_uc010wku.1_Intron|NPEPPS_uc010wkv.1_Intron|NPEPPS_uc002ils.1_3'UTR	NM_006310	NP_006301			aminopeptidase puromycin sensitive						proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0																		---	---	---	---
HOXB9	3219	broad.mit.edu	37	17	46703739	46703739	+	5'UTR	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:46703739delC	uc002inx.2	-	1						NM_024017	NP_076922			homeobox B9						canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	46791072	46791074	+	IGR	DEL	AAA	-	-	rs79858079		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:46791072_46791074delAAA								MIR196A1 (81151 upstream) : PRAC (8018 downstream)																																			---	---	---	---
ABI3	51225	broad.mit.edu	37	17	47295005	47295005	+	Intron	DEL	C	-	-	rs113223751		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47295005delC	uc002iop.1	+						ABI3_uc002ioq.1_Intron	NM_016428	NP_057512			NESH protein isoform 1						cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)												HNSCC(55;0.14)			---	---	---	---
RNF43	54894	broad.mit.edu	37	17	56435161	56435161	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56435161delC	uc002iwf.2	-	8	3932	c.1976delG	c.(1975-1977)GGTfs	p.G659fs	RNF43_uc010wnv.1_Frame_Shift_Del_p.G618fs|RNF43_uc002iwh.3_Frame_Shift_Del_p.G659fs|RNF43_uc002iwg.3_Frame_Shift_Del_p.G659fs|RNF43_uc010dcw.2_Frame_Shift_Del_p.G532fs	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	659	Pro-rich.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
TRIM37	4591	broad.mit.edu	37	17	57126492	57126492	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57126492delT	uc002iwy.3	-						TRIM37_uc002iwz.3_Intron|TRIM37_uc002ixa.3_Intron|TRIM37_uc010woc.1_Intron	NM_001005207	NP_001005207			tripartite motif-containing 37 protein							perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)													Mulibrey_Nanism				---	---	---	---
TMEM49	81671	broad.mit.edu	37	17	57886365	57886366	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57886365_57886366delTT	uc002ixu.3	+						TMEM49_uc010wog.1_Intron|TMEM49_uc010woh.1_Intron|TMEM49_uc010woi.1_Intron|TMEM49_uc010woj.1_Intron	NM_030938	NP_112200			transmembrane protein 49						autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane					0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;1.15e-09)|all cancers(12;1.15e-08)															---	---	---	---
INTS2	57508	broad.mit.edu	37	17	59999199	59999199	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:59999199delA	uc002izn.2	-						INTS2_uc002izm.2_Intron	NM_020748	NP_065799			integrator complex subunit 2						snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3																		---	---	---	---
SMURF2	64750	broad.mit.edu	37	17	62547477	62547477	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62547477delA	uc002jep.1	-						SMURF2_uc002jeq.1_Intron|SMURF2_uc002jer.1_Intron	NM_022739	NP_073576			SMAD specific E3 ubiquitin protein ligase 2						BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)															---	---	---	---
LOC146880	146880	broad.mit.edu	37	17	62750914	62750915	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62750914_62750915delTT	uc010wqc.1	-							NR_026899				Homo sapiens cDNA FLJ30780 fis, clone FEBRA2000856.												0																		---	---	---	---
RGS9	8787	broad.mit.edu	37	17	63186049	63186049	+	Intron	DEL	T	-	-	rs112552969		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:63186049delT	uc002jfe.2	+						RGS9_uc010dem.2_Intron|RGS9_uc002jfd.2_Intron|RGS9_uc002jff.2_Intron|RGS9_uc002jfg.2_Intron	NM_003835	NP_003826			regulator of G-protein signaling 9 isoform 1						intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4																		---	---	---	---
ABCA9	10350	broad.mit.edu	37	17	67041617	67041617	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67041617delG	uc002jhu.2	-						ABCA9_uc010dez.2_Intron|ABCA9_uc002jhv.2_Intron	NM_080283	NP_525022			ATP-binding cassette, sub-family A, member 9						transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)																	---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67161403	67161404	+	Intron	DEL	AT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67161403_67161404delAT	uc010dfa.1	-						ABCA10_uc010wqs.1_Intron|ABCA10_uc010wqt.1_Intron	NM_080282	NP_525021			ATP-binding cassette, sub-family A, member 10						transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
ABCA5	23461	broad.mit.edu	37	17	67264278	67264279	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67264278_67264279insA	uc002jif.2	-						ABCA5_uc002jib.2_Intron|ABCA5_uc002jic.2_Intron|ABCA5_uc002jid.2_Intron|ABCA5_uc002jie.2_Intron|ABCA5_uc002jig.2_Intron	NM_018672	NP_061142			ATP-binding cassette, sub-family A , member 5						cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)																	---	---	---	---
NAT9	26151	broad.mit.edu	37	17	72771628	72771628	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72771628delT	uc002jlq.2	-						NAT9_uc002jlr.2_Intron|TMEM104_uc010wrf.1_5'Flank|TMEM104_uc010wrg.1_5'Flank|TMEM104_uc002jls.3_5'Flank|TMEM104_uc010dfx.2_5'Flank	NM_015654	NP_056469			N-acetyltransferase 9							protein complex	N-acetyltransferase activity				0																		---	---	---	---
SAP30BP	29115	broad.mit.edu	37	17	73664547	73664547	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73664547delT	uc002jpe.2	+						RECQL5_uc010dgk.2_5'Flank|RECQL5_uc010dgl.2_5'Flank|RECQL5_uc002jpb.1_5'Flank|RECQL5_uc002joz.3_5'Flank|RECQL5_uc002jpa.3_5'Flank|SAP30BP_uc010dgm.1_Intron|SAP30BP_uc002jpc.1_Intron|SAP30BP_uc010wsf.1_Intron|SAP30BP_uc010wsg.1_Intron|SAP30BP_uc002jpf.2_Intron	NM_013260	NP_037392			transcriptional regulator protein						apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
RNF213	57674	broad.mit.edu	37	17	78345610	78345610	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78345610delT	uc002jyh.1	+						uc002jyi.1_Intron|RNF213_uc010dhw.1_Intron	NM_020914	NP_065965			ring finger protein 213											ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)															---	---	---	---
MPPE1	65258	broad.mit.edu	37	18	11889574	11889574	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:11889574delT	uc002kqf.2	-						MPPE1_uc002kqn.2_Intron|MPPE1_uc002kqg.2_Intron|MPPE1_uc002kqh.2_Intron|MPPE1_uc002kqi.2_Intron|MPPE1_uc002kqj.2_Intron|MPPE1_uc002kqk.2_Intron|MPPE1_uc002kql.2_Intron|MPPE1_uc002kqm.2_Intron|MPPE1_uc010dla.1_Intron	NM_023075	NP_075563			metallophosphoesterase 1 precursor						ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0																		---	---	---	---
AFG3L2	10939	broad.mit.edu	37	18	12363993	12363993	+	Intron	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12363993delC	uc002kqz.1	-							NM_006796	NP_006787			AFG3 ATPase family gene 3-like 2						cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)													---	---	---	---
MEP1B	4225	broad.mit.edu	37	18	29796832	29796834	+	Intron	DEL	AAA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29796832_29796834delAAA	uc002kxj.3	+							NM_005925	NP_005916			meprin A beta precursor						digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
DTNA	1837	broad.mit.edu	37	18	32405028	32405028	+	Intron	DEL	T	-	-	rs77685796		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:32405028delT	uc010dmn.1	+						DTNA_uc002kxu.2_Intron|DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Intron|DTNA_uc002kxw.2_Intron|DTNA_uc002kxx.2_Intron|DTNA_uc010dmj.2_Intron|DTNA_uc002kxz.2_Intron|DTNA_uc002kxy.2_Intron|DTNA_uc010dmk.1_Intron|DTNA_uc010dml.2_Intron|DTNA_uc002kyb.3_Intron|DTNA_uc010dmm.2_Intron|DTNA_uc010xby.1_Intron|DTNA_uc010dmo.2_Intron|DTNA_uc002kyd.3_Intron|DTNA_uc010xbz.1_Intron|DTNA_uc010xca.1_Intron|DTNA_uc002kye.2_Intron	NM_001390	NP_001381			dystrobrevin alpha isoform 1						neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0																		---	---	---	---
LMAN1	3998	broad.mit.edu	37	18	57021815	57021815	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:57021815delA	uc002lhz.2	-						LMAN1_uc010xek.1_Intron	NM_005570	NP_005561			lectin, mannose-binding, 1 precursor						blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)													---	---	---	---
Unknown	0	broad.mit.edu	37	18	57429214	57429218	+	IGR	DEL	AAAAG	-	-	rs141641247	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:57429214_57429218delAAAAG								CCBE1 (64570 upstream) : PMAIP1 (137974 downstream)																																			---	---	---	---
PALM	5064	broad.mit.edu	37	19	731002	731002	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:731002delA	uc002lpm.1	+						PALM_uc010xft.1_Intron|PALM_uc002lpn.1_Intron|PALM_uc010xfu.1_Intron	NM_002579	NP_002570			paralemmin isoform 1						cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane					0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)														---	---	---	---
AZU1	566	broad.mit.edu	37	19	831081	831082	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:831081_831082delTT	uc002lpz.1	+							NM_001700	NP_001691			azurocidin 1 preproprotein						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			pancreas(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	5576517	5576517	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5576517delT								PLAC2 (8512 upstream) : SAFB2 (10494 downstream)																																			---	---	---	---
ACSBG2	81616	broad.mit.edu	37	19	6176166	6176166	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6176166delA	uc002mef.1	+						ACSBG2_uc002mee.1_Intron|ACSBG2_uc002meg.1_Intron|ACSBG2_uc002meh.1_Intron|ACSBG2_uc002mei.1_Intron|ACSBG2_uc010xiz.1_Intron	NM_030924	NP_112186			bubblegum-related acyl-CoA synthetase 2						cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	9804225	9804225	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9804225delT	uc010xkx.1	-											RecName: Full=Zinc finger protein 562;																														---	---	---	---
EPOR	2057	broad.mit.edu	37	19	11488473	11488473	+	3'UTR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11488473delA	uc002mrh.2	-	2										SubName: Full=Erythropoietin receptor; Flags: Fragment;							extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			ovary(1)	1					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)											OREG0025254	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
Unknown	0	broad.mit.edu	37	19	12757294	12757294	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12757294delA								ZNF791 (16618 upstream) : MAN2B1 (28 downstream)																																			---	---	---	---
C19orf43	79002	broad.mit.edu	37	19	12841615	12841616	+	3'UTR	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12841615_12841616insA	uc002muu.2	-	3						NM_024038	NP_076943			hypothetical protein MGC2803												0																		---	---	---	---
GCDH	2639	broad.mit.edu	37	19	13005288	13005288	+	Intron	DEL	A	-	-	rs35075245		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13005288delA	uc002mvq.2	+						GCDH_uc010xms.1_Intron|GCDH_uc002mvp.2_Intron|GCDH_uc010xmt.1_Intron|GCDH_uc010xmu.1_Intron	NM_000159	NP_000150			glutaryl-Coenzyme A dehydrogenase isoform a						lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0																		---	---	---	---
C19orf44	84167	broad.mit.edu	37	19	16625243	16625243	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16625243delG	uc002neh.1	+						MED26_uc002nee.2_Intron|C19orf44_uc002neg.2_Intron|C19orf44_uc010eai.1_Intron	NM_032207	NP_115583			hypothetical protein LOC84167												0																		---	---	---	---
HAUS8	93323	broad.mit.edu	37	19	17170524	17170524	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17170524delT	uc002nfe.2	-						HAUS8_uc002nff.2_Intron|HAUS8_uc002nfg.1_Intron|HAUS8_uc002nfh.1_Intron	NM_033417	NP_219485			sarcoma antigen NY-SAR-48 isoform a						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0																		---	---	---	---
UNC13A	23025	broad.mit.edu	37	19	17753825	17753826	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17753825_17753826delTT	uc002nhd.2	-							NM_001080421	NP_001073890			unc-13 homolog A						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3																		---	---	---	---
ZNF100	163227	broad.mit.edu	37	19	21948309	21948309	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21948309delT	uc002nqi.2	-							NM_173531	NP_775802			zinc finger protein 100						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF254	9534	broad.mit.edu	37	19	24309044	24309044	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:24309044delT	uc002nru.2	+						ZNF254_uc010xrk.1_Intron	NM_203282	NP_975011			zinc finger protein 254						negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)																---	---	---	---
CCDC123	84902	broad.mit.edu	37	19	33439158	33439158	+	Intron	DEL	T	-	-	rs12710001	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33439158delT	uc002nty.2	-						CCDC123_uc002ntx.2_Intron|CCDC123_uc010edg.2_Intron|CCDC123_uc002ntz.1_Intron|CCDC123_uc002nua.2_Intron|CCDC123_uc002nub.1_Intron	NM_032816	NP_116205			coiled-coil domain containing 123							centrosome|spindle pole					0	Esophageal squamous(110;0.137)																	---	---	---	---
UBA2	10054	broad.mit.edu	37	19	34957656	34957656	+	Intron	DEL	A	-	-	rs71783861		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34957656delA	uc002nvk.2	+						UBA2_uc002nvl.2_Intron	NM_005499	NP_005490			SUMO-1 activating enzyme subunit 2						protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)															---	---	---	---
CD22	933	broad.mit.edu	37	19	35826795	35826795	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35826795delA	uc010edt.2	+						CD22_uc010xst.1_Intron|CD22_uc010edu.2_Intron|CD22_uc010edv.2_Intron|CD22_uc002nzb.3_Intron|CD22_uc010edx.2_5'Flank	NM_001771	NP_001762			CD22 molecule precursor						cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)													---	---	---	---
CYP2S1	29785	broad.mit.edu	37	19	41706982	41706983	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41706982_41706983delAA	uc002opw.2	+						CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Intron	NM_030622	NP_085125			cytochrome P450, family 2, subfamily S,						xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1																		---	---	---	---
CEACAM1	634	broad.mit.edu	37	19	43016797	43016797	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43016797delT	uc002otv.2	-						uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|CEACAM1_uc010eii.2_Intron|CEACAM1_uc002otw.2_Intron|CEACAM1_uc010eij.2_Intron|CEACAM1_uc002otx.2_Intron|CEACAM1_uc002oty.2_Intron|CEACAM1_uc002otz.2_Intron|CEACAM1_uc010eik.2_Intron	NM_001712	NP_001703			carcinoembryonic antigen-related cell adhesion						angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				ovary(1)|central_nervous_system(1)	2		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)													---	---	---	---
IRGQ	126298	broad.mit.edu	37	19	44096566	44096568	+	In_Frame_Del	DEL	GCC	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44096566_44096568delGCC	uc002oww.2	-	2	1600_1602	c.1482_1484delGGC	c.(1480-1485)GCGGCA>GCA	p.494_495AA>A	IRGQ_uc010eiv.2_In_Frame_Del_p.494_495AA>A	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	494_495	Ala-rich.						protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)																---	---	---	---
KLC3	147700	broad.mit.edu	37	19	45852955	45852956	+	Intron	INS	-	GGGT	GGGT	rs72410259		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45852955_45852956insGGGT	uc002pbf.1	+						KLC3_uc010ejy.1_Intron|KLC3_uc002pbg.1_Intron	NM_177417	NP_803136			kinesin light chain 3							cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)														---	---	---	---
EHD2	30846	broad.mit.edu	37	19	48239464	48239465	+	Intron	INS	-	AG	AG			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48239464_48239465insAG	uc002phj.3	+						EHD2_uc010xyu.1_Intron|EHD2_uc010xyv.1_Intron	NM_014601	NP_055416			EH-domain containing 2						blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)														---	---	---	---
SULT2B1	6820	broad.mit.edu	37	19	49094730	49094731	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49094730_49094731delAA	uc002pjl.2	+						SULT2B1_uc002pjm.2_Intron	NM_177973	NP_814444			sulfotransferase family, cytosolic, 2B, member 1						3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			skin(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)														---	---	---	---
ZNF534	147658	broad.mit.edu	37	19	52955324	52955324	+	3'UTR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52955324delT	uc002pzj.1	+	5					ZNF534_uc010epo.1_3'UTR|ZNF578_uc002pzm.2_5'Flank|ZNF578_uc002pzn.2_5'Flank|ZNF578_uc002pzp.3_5'Flank|ZNF578_uc002pzo.1_5'Flank|ZNF578_uc010epp.1_5'Flank					SubName: Full=Putative uncharacterized protein;						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF808	388558	broad.mit.edu	37	19	53067677	53067677	+	RNA	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53067677delA	uc002pzq.2	+	4		c.4189delA								Homo sapiens zinc finger protein 808, mRNA (cDNA clone IMAGE:3542548), complete cds.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)														---	---	---	---
KIR2DL4	3805	broad.mit.edu	37	19	55324675	55324675	+	Splice_Site	DEL	A	-	-	rs66505238		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55324675delA	uc010yfm.1	+	6	841	c.801_splice	c.e6+1	p.S267_splice	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_Frame_Shift_Del_p.K263fs|KIR2DL4_uc002qhg.2_Intron|KIR2DL4_uc002qhi.2_Frame_Shift_Del_p.K251fs|KIR2DL4_uc002qhh.2_Intron|KIR2DL4_uc002qhj.2_Intron|KIR2DL4_uc002qhf.2_Intron|KIR2DL4_uc010esd.2_Intron|KIR2DL4_uc010ese.2_RNA	NM_002255	NP_002246			killer cell immunoglobulin-like receptor, two						cellular defense response|regulation of immune response	integral to plasma membrane	protein binding|transmembrane receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0192)														---	---	---	---
TMEM86B	255043	broad.mit.edu	37	19	55740217	55740218	+	5'UTR	DEL	TG	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55740217_55740218delTG	uc002qju.2	-	1					TMEM86B_uc002qjt.2_5'Flank	NM_173804	NP_776165			transmembrane protein 86B						ether lipid metabolic process	cytoplasmic part|integral to membrane	alkenylglycerophosphocholine hydrolase activity|alkenylglycerophosphoethanolamine hydrolase activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	58727943	58727943	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58727943delA								ZNF274 (3016 upstream) : ZNF544 (12127 downstream)																																			---	---	---	---
PYGB	5834	broad.mit.edu	37	20	25251794	25251794	+	Intron	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25251794delC	uc002wup.2	+							NM_002862	NP_002853			brain glycogen phosphorylase						glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)													---	---	---	---
ASXL1	171023	broad.mit.edu	37	20	30957061	30957061	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30957061delT	uc002wxs.2	+						ASXL1_uc002wxr.1_Intron|ASXL1_uc002wxt.2_Intron|ASXL1_uc010geb.2_Intron	NM_015338	NP_056153			additional sex combs like 1 isoform 1						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248								F|N|Mis		MDS|CMML								---	---	---	---
RBM39	9584	broad.mit.edu	37	20	34297361	34297361	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34297361delT	uc002xeb.2	-						RBM39_uc002xdz.2_Intron|RBM39_uc002xea.2_Intron|RBM39_uc010gfn.2_Intron|RBM39_uc010zvm.1_Intron|RBM39_uc002xeg.2_Intron|RBM39_uc002xec.2_Intron|RBM39_uc002xed.2_Intron|RBM39_uc002xee.2_Intron|RBM39_uc002xef.2_Intron|RBM39_uc010zvn.1_Intron	NM_184234	NP_909122			RNA binding motif protein 39 isoform a						mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)																	---	---	---	---
NDRG3	57446	broad.mit.edu	37	20	35349931	35349931	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35349931delA	uc002xfw.2	-						NDRG3_uc002xfx.2_Intron|NDRG3_uc010zvq.1_Intron|NDRG3_uc010zvr.1_Intron	NM_032013	NP_114402			N-myc downstream regulated gene 3 isoform a						cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)																---	---	---	---
RBL1	5933	broad.mit.edu	37	20	35632424	35632425	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35632424_35632425delTT	uc002xgi.2	-						RBL1_uc010zvt.1_Intron|RBL1_uc002xgj.1_Intron	NM_002895	NP_002886			retinoblastoma-like protein 1 isoform a						cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)																---	---	---	---
KIAA0406	9675	broad.mit.edu	37	20	36639839	36639840	+	Intron	INS	-	A	A	rs144090249	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:36639839_36639840insA	uc002xhl.2	-						KIAA0406_uc002xhm.2_Intron	NM_014657	NP_055472			hypothetical protein LOC9675								binding				0		Myeloproliferative disorder(115;0.00874)																---	---	---	---
Unknown	0	broad.mit.edu	37	20	41899706	41899706	+	IGR	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:41899706delA								PTPRT (81149 upstream) : SFRS6 (186798 downstream)																																			---	---	---	---
EYA2	2139	broad.mit.edu	37	20	45789429	45789430	+	Intron	DEL	TT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:45789429_45789430delTT	uc002xsm.2	+						EYA2_uc010ghp.2_Intron|EYA2_uc002xsn.2_Intron|EYA2_uc002xso.2_Intron|EYA2_uc002xsp.2_Intron|EYA2_uc002xsq.2_Intron	NM_005244	NP_005235			eyes absent 2 isoform a						DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)																---	---	---	---
SLC9A8	23315	broad.mit.edu	37	20	48494743	48494743	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:48494743delA	uc002xuv.1	+						SLC9A8_uc010zym.1_Intron|SLC9A8_uc010gic.2_Intron|SLC9A8_uc010gid.2_Intron	NM_015266	NP_056081			sodium/hydrogen exchanger 8							Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)															---	---	---	---
NCAM2	4685	broad.mit.edu	37	21	22881130	22881149	+	Intron	DEL	TTTTTTTTTTTTTTTTTTTT	-	-	rs72167467		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:22881130_22881149delTTTTTTTTTTTTTTTTTTTT	uc002yld.1	+						NCAM2_uc011acb.1_Intron	NM_004540	NP_004531			neural cell adhesion molecule 2 precursor						neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)														---	---	---	---
HUNK	30811	broad.mit.edu	37	21	33346634	33346635	+	Intron	INS	-	A	A	rs113469359		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33346634_33346635insA	uc002yph.2	+							NM_014586	NP_055401			hormonally upregulated Neu-associated kinase						multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2																		---	---	---	---
GART	2618	broad.mit.edu	37	21	34906683	34906683	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34906683delT	uc002yrx.2	-						GART_uc002yrz.2_Intron|GART_uc010gmd.2_Intron|GART_uc002yry.2_Intron|GART_uc002ysa.2_Intron	NM_000819	NP_000810			phosphoribosylglycinamide formyltransferase,						'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)													---	---	---	---
ITGB2	3689	broad.mit.edu	37	21	46320406	46320406	+	Intron	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46320406delG	uc002zgd.2	-						ITGB2_uc002zge.2_Intron|ITGB2_uc002zgf.3_Intron|ITGB2_uc011afl.1_Intron|ITGB2_uc010gpw.2_Intron|ITGB2_uc002zgg.2_Intron	NM_001127491	NP_001120963			integrin, beta 2 precursor						apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)													---	---	---	---
DIP2A	23181	broad.mit.edu	37	21	47974384	47974384	+	Intron	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47974384delC	uc002zjo.2	+						DIP2A_uc011afy.1_Intron|DIP2A_uc011afz.1_Intron|DIP2A_uc002zjr.2_Intron	NM_015151	NP_055966			disco-interacting protein 2A isoform a						multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)														---	---	---	---
SLC5A1	6523	broad.mit.edu	37	22	32481283	32481283	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32481283delT	uc003amc.2	+						SLC5A1_uc011alz.1_Intron	NM_000343	NP_000334			solute carrier family 5 (sodium/glucose						carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1																		---	---	---	---
MKL1	57591	broad.mit.edu	37	22	40813065	40813065	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40813065delA	uc003ayv.1	-						MKL1_uc003ayw.1_Intron|MKL1_uc010gye.1_Intron|MKL1_uc010gyf.1_Intron	NM_020831	NP_065882			megakaryoblastic leukemia 1 protein						positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5								T	RBM15	acute megakaryocytic leukemia								---	---	---	---
NHP2L1	4809	broad.mit.edu	37	22	42071433	42071433	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42071433delT	uc003bat.2	-						NHP2L1_uc003bau.2_Intron|NHP2L1_uc003bav.2_Intron|NHP2L1_uc003baw.2_Intron	NM_005008	NP_004999			NHP2 non-histone chromosome protein 2-like 1						nuclear mRNA splicing, via spliceosome|ribosome biogenesis	box C/D snoRNP complex|nucleoplasm|spliceosomal complex	protein binding|RNA binding				0																		---	---	---	---
TCF20	6942	broad.mit.edu	37	22	42611474	42611477	+	5'Flank	DEL	TTTT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42611474_42611477delTTTT	uc003bcj.1	-						TCF20_uc003bck.1_5'Flank|TCF20_uc003bnt.2_5'Flank	NM_005650	NP_005641			transcription factor 20 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5																		---	---	---	---
RRP7B	91695	broad.mit.edu	37	22	42973810	42973810	+	Intron	DEL	C	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42973810delC	uc003bcs.2	-						RRP7B_uc003bct.2_Intron					Homo sapiens cDNA FLJ90011 fis, clone HEMBA1000443, highly similar to Gastric cancer antigen Zg14.												0																		---	---	---	---
SMC1B	27127	broad.mit.edu	37	22	45754477	45754477	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45754477delA	uc003bgc.2	-						SMC1B_uc003bgd.2_Intron	NM_148674	NP_683515			SMC1 structural maintenance of chromosomes						chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)														---	---	---	---
ASMT	438	broad.mit.edu	37	X	1742326	1742326	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1742326delA	uc004cqd.2	+						ASMT_uc010ncy.2_Intron|ASMT_uc004cqe.2_Intron	NM_004043	NP_004034			acetylserotonin O-methyltransferase						melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
ARHGAP6	395	broad.mit.edu	37	X	11352232	11352235	+	Intron	DEL	AAAA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11352232_11352235delAAAA	uc004cup.1	-						ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron	NM_013427	NP_038286			Rho GTPase activating protein 6 isoform 1						actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2																		---	---	---	---
EGFL6	25975	broad.mit.edu	37	X	13642155	13642155	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:13642155delT	uc004cvi.2	+						EGFL6_uc004cvj.2_Intron	NM_015507	NP_056322			epidermal growth factor-like protein 6						cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2																		---	---	---	---
ASB9	140462	broad.mit.edu	37	X	15273107	15273108	+	Intron	DEL	AA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15273107_15273108delAA	uc004cwl.2	-						ASB9_uc004cwk.2_Intron|ASB9_uc004cwm.2_Intron|ASB9_uc010ner.2_Intron|ASB9_uc004cwn.2_Intron	NM_001031739	NP_001026909			ankyrin repeat and SOCS box-containing 9 isoform						intracellular signal transduction						0	Hepatocellular(33;0.183)																	---	---	---	---
ACE2	59272	broad.mit.edu	37	X	15619104	15619105	+	5'UTR	DEL	TC	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15619104_15619105delTC	uc004cxa.1	-	1					ACE2_uc004cxb.2_5'UTR	NM_021804	NP_068576			angiotensin I converting enzyme 2 precursor						angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)													---	---	---	---
GPR64	10149	broad.mit.edu	37	X	19012967	19012967	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:19012967delA	uc004cyx.2	-						GPR64_uc004cyy.2_Intron|GPR64_uc004cyz.2_Intron|GPR64_uc004czb.2_Intron|GPR64_uc004czc.2_Intron|GPR64_uc004czd.2_Intron|GPR64_uc004cze.2_Intron|GPR64_uc004czf.2_Intron|GPR64_uc004cza.2_Intron|GPR64_uc004cyw.2_Intron|GPR64_uc010nfj.2_Intron	NM_001079858	NP_001073327			G protein-coupled receptor 64 isoform 1						neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
APOO	79135	broad.mit.edu	37	X	23896839	23896846	+	Intron	DEL	CTTGCTAT	-	-	rs56274557		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:23896839_23896846delCTTGCTAT	uc004dax.2	-						APOO_uc004daw.2_Intron|APOO_uc004day.3_Intron	NM_024122	NP_077027			apolipoprotein O precursor						lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle					0																		---	---	---	---
IL1RAPL1	11141	broad.mit.edu	37	X	29973069	29973069	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:29973069delA	uc004dby.2	+							NM_014271	NP_055086			interleukin 1 receptor accessory protein-like 1						innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5																		---	---	---	---
TAB3	257397	broad.mit.edu	37	X	30861223	30861223	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30861223delT	uc004dcj.2	-						TAB3_uc004dck.2_Intron|TAB3_uc010ngl.2_Intron	NM_152787	NP_690000			mitogen-activated protein kinase kinase kinase 7						activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
TAB3	257397	broad.mit.edu	37	X	30870765	30870766	+	Intron	INS	-	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30870765_30870766insA	uc004dcj.2	-						TAB3_uc004dck.2_Intron|TAB3_uc010ngl.2_Intron	NM_152787	NP_690000			mitogen-activated protein kinase kinase kinase 7						activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
DDX3X	1654	broad.mit.edu	37	X	41196896	41196901	+	Intron	DEL	TTTTTT	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41196896_41196901delTTTTTT	uc004dfe.2	+						DDX3X_uc004dfd.1_Intron|DDX3X_uc010nhf.1_Intron|DDX3X_uc004dff.2_Intron|DDX3X_uc011mkq.1_Intron|DDX3X_uc011mkr.1_Intron|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_Intron|DDX3X_uc011mkt.1_Intron	NM_001356	NP_001347			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3						interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6															HNSCC(61;0.18)			---	---	---	---
DDX3X	1654	broad.mit.edu	37	X	41198279	41198279	+	Intron	DEL	A	-	-	rs112766093		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41198279delA	uc004dfe.2	+						DDX3X_uc010nhf.1_Intron|DDX3X_uc004dff.2_Intron|DDX3X_uc011mkq.1_Intron|DDX3X_uc011mkr.1_Intron|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_Intron|DDX3X_uc011mkt.1_Intron	NM_001356	NP_001347			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3						interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6															HNSCC(61;0.18)			---	---	---	---
FAM104B	90736	broad.mit.edu	37	X	55172448	55172449	+	Intron	INS	-	T	T	rs5902536		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:55172448_55172449insT	uc004duh.1	-						FAM104B_uc004dug.1_Intron|FAM104B_uc004dui.3_3'UTR	NM_138362	NP_612371			hypothetical protein LOC90736												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	64548439	64548439	+	IGR	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64548439delT								ZC4H2 (293846 upstream) : ZC3H12B (160267 downstream)																																			---	---	---	---
IL2RG	3561	broad.mit.edu	37	X	70327614	70327614	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70327614delG	uc004dyw.1	-	8	1096	c.1082delC	c.(1081-1083)CCAfs	p.P361fs	CXorf65_uc011mpo.1_5'Flank|CXorf65_uc011mpp.1_5'Flank|IL2RG_uc004dyv.1_Frame_Shift_Del_p.P90fs|IL2RG_uc004dyx.1_Frame_Shift_Del_p.P171fs	NM_000206	NP_000197	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma precursor	361	Cytoplasmic (Potential).				immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			pancreas(1)	1	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)									Severe_Combined_Immunodeficiency_X-linked				---	---	---	---
NCRNA00182	100302692	broad.mit.edu	37	X	73507434	73507434	+	Intron	DEL	T	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73507434delT	uc010nlq.1	-						NCRNA00182_uc004ebr.1_Intron|MIR545_hsa-mir-545|MI0003516_5'Flank|MIR374A_hsa-mir-374a|MI0000782_5'Flank|uc011mqm.1_5'Flank					Homo sapiens cDNA FLJ33139 fis, clone UTERU1000109.												0																		---	---	---	---
THOC2	57187	broad.mit.edu	37	X	122774558	122774558	+	Intron	DEL	A	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:122774558delA	uc004etu.2	-						THOC2_uc011muh.1_Intron	NM_001081550	NP_001075019			THO complex 2						intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3																		---	---	---	---
CD40LG	959	broad.mit.edu	37	X	135730206	135730210	+	5'Flank	DEL	AAAAA	-	-			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135730206_135730210delAAAAA	uc004faa.2	+						CD40LG_uc010nsd.2_5'Flank|CD40LG_uc010nse.1_5'Flank	NM_000074	NP_000065			CD40 ligand						anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)									Immune_Deficiency_with_Hyper-IgM				---	---	---	---
UBE2J2	118424	broad.mit.edu	37	1	1192586	1192586	+	Splice_Site	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1192586A>G	uc001adn.2	-	4	585	c.275_splice	c.e4+1	p.R92_splice	UBE2J2_uc001adm.2_Splice_Site_p.R57_splice|UBE2J2_uc001ado.2_Splice_Site_p.R108_splice|UBE2J2_uc001adp.2_Splice_Site_p.R92_splice|UBE2J2_uc001adq.2_Splice_Site_p.R40_splice|UBE2J2_uc001adr.2_Splice_Site_p.R40_splice|UBE2J2_uc001ads.2_Splice_Site_p.R40_splice	NM_194458	NP_919440			ubiquitin conjugating enzyme E2, J2 isoform 3						response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)														---	---	---	---
ACAP3	116983	broad.mit.edu	37	1	1235530	1235530	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1235530G>A	uc001aeb.2	-						ACAP3_uc001ady.2_5'Flank|ACAP3_uc001aea.2_Intron|ACAP3_uc001aec.1_Intron	NM_030649	NP_085152			ArfGAP with coiled-coil, ankyrin repeat and PH						filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0																		---	---	---	---
CCNL2	81669	broad.mit.edu	37	1	1326184	1326184	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1326184C>T	uc001afi.2	-	6	753	c.721G>A	c.(721-723)GCC>ACC	p.A241T	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Missense_Mutation_p.A19T|CCNL2_uc001afg.1_Missense_Mutation_p.A19T|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	241	Cyclin-like 2.				regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)														---	---	---	---
MIB2	142678	broad.mit.edu	37	1	1563724	1563724	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1563724T>C	uc001agg.2	+	15	2214	c.2087T>C	c.(2086-2088)CTG>CCG	p.L696P	MIB2_uc001agh.2_Missense_Mutation_p.L682P|MIB2_uc001agi.2_Missense_Mutation_p.L692P|MIB2_uc001agj.2_Missense_Mutation_p.L537P|MIB2_uc001agk.2_Missense_Mutation_p.L631P|MIB2_uc001agl.1_Missense_Mutation_p.L652P|MIB2_uc001agm.2_Missense_Mutation_p.L573P|MIB2_uc010nyq.1_Missense_Mutation_p.L652P|MIB2_uc009vkh.2_Missense_Mutation_p.L502P|MIB2_uc001agn.2_Missense_Mutation_p.L328P|MIB2_uc001ago.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	696	ANK 6.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)														---	---	---	---
KIAA1751	85452	broad.mit.edu	37	1	1905549	1905549	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1905549G>A	uc001aim.1	-	7	745	c.589C>T	c.(589-591)CGG>TGG	p.R197W	KIAA1751_uc009vkz.1_Missense_Mutation_p.R197W	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	197										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)														---	---	---	---
SKI	6497	broad.mit.edu	37	1	2237529	2237529	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2237529G>A	uc001aja.3	+	6	1910	c.1838G>A	c.(1837-1839)CGG>CAG	p.R613Q		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	613	Potential.				anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)														---	---	---	---
PANK4	55229	broad.mit.edu	37	1	2445527	2445527	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2445527C>T	uc001ajm.1	-	12	1498	c.1489G>A	c.(1489-1491)GCC>ACC	p.A497T	PANK4_uc010nza.1_Missense_Mutation_p.A458T	NM_018216	NP_060686	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	497					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)														---	---	---	---
ACTRT2	140625	broad.mit.edu	37	1	2938781	2938781	+	Silent	SNP	C	T	T	rs149989896		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2938781C>T	uc001ajz.2	+	1	736	c.531C>T	c.(529-531)CAC>CAT	p.H177H		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	177						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)														---	---	---	---
TNFRSF9	3604	broad.mit.edu	37	1	7993307	7993307	+	Silent	SNP	C	T	T	rs143532137		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:7993307C>T	uc001aot.2	-	7	722	c.594G>A	c.(592-594)GCG>GCA	p.A198A		NM_001561	NP_001552	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily,	198	Helical; (Potential).				induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
KIF1B	23095	broad.mit.edu	37	1	10364070	10364070	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10364070C>T	uc001aqx.3	+						KIF1B_uc001aqv.3_Missense_Mutation_p.R943W|KIF1B_uc001aqw.3_Intron|KIF1B_uc001aqy.2_Intron|KIF1B_uc001aqz.2_Intron|KIF1B_uc001ara.2_Intron|KIF1B_uc001arb.2_Intron	NM_015074	NP_055889			kinesin family member 1B isoform b						anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
CASZ1	54897	broad.mit.edu	37	1	10700075	10700075	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10700075G>A	uc001aro.2	-	21	4524	c.4204C>T	c.(4204-4206)CGC>TGC	p.R1402C		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)														---	---	---	---
CASZ1	54897	broad.mit.edu	37	1	10713999	10713999	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10713999C>T	uc001aro.2	-	11	2435	c.2115G>A	c.(2113-2115)CTG>CTA	p.L705L	CASZ1_uc001arp.1_Silent_p.L705L|CASZ1_uc009vmx.2_Silent_p.L729L	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)														---	---	---	---
CASZ1	54897	broad.mit.edu	37	1	10720396	10720396	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10720396G>A	uc001aro.2	-	6	1023	c.703C>T	c.(703-705)CGG>TGG	p.R235W	CASZ1_uc001arp.1_Missense_Mutation_p.R235W|CASZ1_uc009vmx.2_Missense_Mutation_p.R259W|CASZ1_uc001arq.1_Missense_Mutation_p.R94W	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)														---	---	---	---
VPS13D	55187	broad.mit.edu	37	1	12460264	12460264	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12460264G>A	uc001atv.2	+	61	11802	c.11661G>A	c.(11659-11661)ACG>ACA	p.T3887T	VPS13D_uc001atw.2_Silent_p.T3862T|VPS13D_uc001atx.2_Silent_p.T3074T|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3886					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)														---	---	---	---
KAZ	23254	broad.mit.edu	37	1	15386668	15386668	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:15386668C>T	uc001avm.3	+	6	1198	c.917C>T	c.(916-918)GCG>GTG	p.A306V	KAZ_uc009vog.1_Missense_Mutation_p.A306V|KAZ_uc010obj.1_Missense_Mutation_p.A306V|KAZ_uc001avo.2_Missense_Mutation_p.A300V|KAZ_uc001avp.2_Missense_Mutation_p.A212V|KAZ_uc001avq.2_Missense_Mutation_p.A212V|KAZ_uc001avr.2_Missense_Mutation_p.A209V	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	306	Interaction with PPL.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0																		---	---	---	---
AGMAT	79814	broad.mit.edu	37	1	15905525	15905525	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:15905525G>A	uc001awv.1	-	4	692	c.549C>T	c.(547-549)CAC>CAT	p.H183H	DNAJC16_uc001awu.2_Intron	NM_024758	NP_079034	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase) precursor	183					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			skin(1)	1		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
SPEN	23013	broad.mit.edu	37	1	16199371	16199371	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16199371T>C	uc001axk.1	+	2	348	c.144T>C	c.(142-144)GCT>GCC	p.A48A	SPEN_uc010obp.1_5'Flank	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	48	By similarity.|RRM 1.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding	p.A48T(1)		ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
SPEN	23013	broad.mit.edu	37	1	16261133	16261133	+	Missense_Mutation	SNP	G	A	A	rs140025266	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16261133G>A	uc001axk.1	+	11	8602	c.8398G>A	c.(8398-8400)GCG>ACG	p.A2800T	SPEN_uc010obp.1_Missense_Mutation_p.A2759T	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2800	Interaction with RBPSUH (By similarity).				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
CLCNKB	1188	broad.mit.edu	37	1	16377403	16377403	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16377403G>A	uc001axw.3	+	12	1167	c.1087G>A	c.(1087-1089)GAC>AAC	p.D363N	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.D363N|CLCNKB_uc001axy.3_Missense_Mutation_p.D194N	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	363					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CLCNKB	1188	broad.mit.edu	37	1	16378782	16378782	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16378782C>T	uc001axw.3	+	15	1578	c.1498C>T	c.(1498-1500)CCC>TCC	p.P500S	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.P500S|CLCNKB_uc001axy.3_Missense_Mutation_p.P331S	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	500	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
SDHB	6390	broad.mit.edu	37	1	17371343	17371343	+	Missense_Mutation	SNP	C	T	T	rs143058777		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17371343C>T	uc001bae.2	-	2	264	c.113G>A	c.(112-114)CGT>CAT	p.R38H		NM_003000	NP_002991	P21912	DHSB_HUMAN	succinate dehydrogenase complex, subunit B, iron	38					respiratory electron transport chain|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	2 iron, 2 sulfur cluster binding|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|protein binding|succinate dehydrogenase (ubiquinone) activity|ubiquinone binding			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0049)|COAD - Colon adenocarcinoma(227;1.18e-05)|BRCA - Breast invasive adenocarcinoma(304;2.41e-05)|Kidney(64;0.000188)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)	Succinic acid(DB00139)			Mis|N|F			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome|Cowden_syndrome				---	---	---	---
SH2D5	400745	broad.mit.edu	37	1	21051063	21051063	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21051063C>T	uc001bdt.1	-	5	829	c.204G>A	c.(202-204)GAG>GAA	p.E68E	SH2D5_uc009vpy.1_Silent_p.E152E|SH2D5_uc001bdu.1_RNA	NM_001103160	NP_001096630	Q6ZV89	SH2D5_HUMAN	SH2 domain containing 5 isoform 2	68											0		Colorectal(325;3.46e-05)|all_lung(284;5.32e-05)|Lung NSC(340;5.51e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|GBM - Glioblastoma multiforme(114;0.000465)|Kidney(64;0.000476)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(64;0.00634)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)														---	---	---	---
ALPL	249	broad.mit.edu	37	1	21890655	21890655	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21890655C>T	uc001bet.2	+	6	851	c.594C>T	c.(592-594)AGC>AGT	p.S198S	ALPL_uc010odn.1_Silent_p.S146S|ALPL_uc010odo.1_Silent_p.S143S|ALPL_uc010odp.1_Silent_p.S121S|ALPL_uc001beu.3_Silent_p.S198S	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	198					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)													---	---	---	---
HSPG2	3339	broad.mit.edu	37	1	22206641	22206641	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22206641C>A	uc001bfj.2	-	17	2342	c.2302G>T	c.(2302-2304)GGC>TGC	p.G768C	HSPG2_uc009vqd.2_Missense_Mutation_p.G769C	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	768	Laminin EGF-like 2.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)													---	---	---	---
LUZP1	7798	broad.mit.edu	37	1	23419294	23419294	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23419294C>T	uc001bgk.2	-	4	1845	c.1461G>A	c.(1459-1461)GCG>GCA	p.A487A	LUZP1_uc010odv.1_Silent_p.A487A|LUZP1_uc001bgl.2_Silent_p.A487A|LUZP1_uc001bgm.1_Silent_p.A487A	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	487						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)														---	---	---	---
CLIC4	25932	broad.mit.edu	37	1	25166340	25166340	+	Intron	SNP	T	C	C	rs41268781		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25166340T>C	uc001bjo.2	+						CLIC4_uc001bjn.2_Intron|CLIC4_uc001bjp.1_Intron	NM_013943	NP_039234			chloride intracellular channel 4						cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)														---	---	---	---
RUNX3	864	broad.mit.edu	37	1	25245743	25245743	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25245743G>A	uc001bjq.2	-	3	943	c.532C>T	c.(532-534)CGG>TGG	p.R178W	RUNX3_uc010oen.1_Missense_Mutation_p.R178W|RUNX3_uc009vrj.2_Missense_Mutation_p.R192W|RUNX3_uc001bjr.2_Missense_Mutation_p.R192W	NM_004350	NP_004341	Q13761	RUNX3_HUMAN	runt-related transcription factor 3 isoform 2	178	Runt.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)														---	---	---	---
AIM1L	55057	broad.mit.edu	37	1	26672634	26672634	+	5'Flank	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26672634T>C	uc001bmd.3	-						uc009vsi.1_Missense_Mutation_p.Y172C	NM_001039775	NP_001034864			absent in melanoma 1-like								sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)														---	---	---	---
RPS6KA1	6195	broad.mit.edu	37	1	26881655	26881655	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26881655C>T	uc001bmr.1	+	10	933	c.770C>T	c.(769-771)ACG>ATG	p.T257M	RPS6KA1_uc010ofe.1_Missense_Mutation_p.T165M|RPS6KA1_uc010off.1_Missense_Mutation_p.T241M|RPS6KA1_uc001bms.1_Missense_Mutation_p.T266M|RPS6KA1_uc009vsl.1_Missense_Mutation_p.T100M	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	257	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)														---	---	---	---
SLC9A1	6548	broad.mit.edu	37	1	27426921	27426921	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27426921G>A	uc001bnm.2	-	12	2951	c.2325C>T	c.(2323-2325)GAC>GAT	p.D775D	SLC9A1_uc001bnl.2_Silent_p.D279D|SLC9A1_uc010ofk.1_Silent_p.D436D	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	775	Cytoplasmic (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)													---	---	---	---
SLC9A1	6548	broad.mit.edu	37	1	27436222	27436222	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27436222C>T	uc001bnm.2	-	3	1486	c.860G>A	c.(859-861)GGC>GAC	p.G287D	SLC9A1_uc010ofk.1_5'UTR|SLC9A1_uc001bnn.2_Missense_Mutation_p.G287D	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	287	Extracellular (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)													---	---	---	---
PTAFR	5724	broad.mit.edu	37	1	28476770	28476770	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28476770A>G	uc001bpl.2	-	2	890	c.763T>C	c.(763-765)TGG>CGG	p.W255R	PTAFR_uc001bpm.3_Missense_Mutation_p.W255R|PTAFR_uc009vte.2_Missense_Mutation_p.W255R	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	255	Extracellular (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PTPRU	10076	broad.mit.edu	37	1	29587410	29587410	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29587410G>A	uc001bru.2	+	7	1249	c.1139G>A	c.(1138-1140)TGC>TAC	p.C380Y	PTPRU_uc001brv.2_Missense_Mutation_p.C380Y|PTPRU_uc001brw.2_Missense_Mutation_p.C380Y|PTPRU_uc009vtq.2_Missense_Mutation_p.C380Y|PTPRU_uc009vtr.2_Missense_Mutation_p.C380Y	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	380	Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)														---	---	---	---
COL16A1	1307	broad.mit.edu	37	1	32148593	32148593	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32148593C>A	uc001btk.1	-	37	2845	c.2480G>T	c.(2479-2481)GGG>GTG	p.G827V	COL16A1_uc001btj.1_Missense_Mutation_p.G656V|COL16A1_uc001btl.3_Missense_Mutation_p.G827V	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	827	Triple-helical region 5 (COL5) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)														---	---	---	---
BAI2	576	broad.mit.edu	37	1	32221745	32221745	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32221745G>A	uc001btn.2	-	4	1047	c.693C>T	c.(691-693)GCC>GCT	p.A231A	BAI2_uc010ogp.1_Silent_p.A219A|BAI2_uc010ogq.1_Silent_p.A231A|BAI2_uc001bto.2_Silent_p.A231A|BAI2_uc001btq.1_Silent_p.A219A|BAI2_uc010ogr.1_Silent_p.A219A	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	231	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)														---	---	---	---
SPOCD1	90853	broad.mit.edu	37	1	32280436	32280436	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32280436C>T	uc001bts.1	-	2	557	c.499G>A	c.(499-501)GCC>ACC	p.A167T	SPOCD1_uc001btu.2_Missense_Mutation_p.A167T|SPOCD1_uc001btv.2_Intron	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	167					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)														---	---	---	---
KHDRBS1	10657	broad.mit.edu	37	1	32508218	32508218	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32508218G>A	uc001bub.2	+	9	1431	c.1325G>A	c.(1324-1326)CGT>CAT	p.R442H	KHDRBS1_uc001bua.1_Missense_Mutation_p.R403H|KHDRBS1_uc001buc.1_RNA	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal	442					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)																---	---	---	---
TMEM39B	55116	broad.mit.edu	37	1	32566073	32566073	+	Silent	SNP	C	T	T	rs148218352	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32566073C>T	uc010ogv.1	+	8	1292	c.1146C>T	c.(1144-1146)GGC>GGT	p.G382G	TMEM39B_uc010ogt.1_RNA|TMEM39B_uc010ogu.1_Silent_p.G255G|TMEM39B_uc001bue.3_Silent_p.G383G|TMEM39B_uc001buf.3_Silent_p.G183G|TMEM39B_uc010ogw.1_Silent_p.G183G	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	382						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)																---	---	---	---
TMEM39B	55116	broad.mit.edu	37	1	32568262	32568262	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32568262C>T	uc010ogv.1	+	9	1613	c.1467C>T	c.(1465-1467)CAC>CAT	p.H489H	TMEM39B_uc001bue.3_Silent_p.H490H|TMEM39B_uc001buf.3_Silent_p.H290H|TMEM39B_uc010ogw.1_Silent_p.H290H	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	489						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)																---	---	---	---
YARS	8565	broad.mit.edu	37	1	33276252	33276252	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33276252C>A	uc001bvy.1	-	3	1108	c.320G>T	c.(319-321)AGC>ATC	p.S107I		NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	107					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)													---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	34042964	34042964	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:34042964C>A	uc001bxn.1	-	50	7543	c.7514G>T	c.(7513-7515)AGC>ATC	p.S2505I	CSMD2_uc001bxm.1_Missense_Mutation_p.S2503I	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2505	Sushi 14.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	34209180	34209180	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:34209180G>A	uc001bxn.1	-	14	1783	c.1754C>T	c.(1753-1755)CCG>CTG	p.P585L	CSMD2_uc001bxm.1_Missense_Mutation_p.P625L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	585	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
DLGAP3	58512	broad.mit.edu	37	1	35370066	35370066	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35370066C>T	uc001byc.2	-	1	919	c.919G>A	c.(919-921)GGG>AGG	p.G307R		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	307					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)																---	---	---	---
SFPQ	6421	broad.mit.edu	37	1	35650046	35650046	+	3'UTR	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35650046A>G	uc001bys.2	-	10					SFPQ_uc001byr.2_Intron	NM_005066	NP_005057			splicing factor proline/glutamine rich						alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|protein binding|RNA binding		SFPQ/TFE3(6)	kidney(4)|soft_tissue(2)|ovary(1)|skin(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)						T	TFE3	papillary renal cell								---	---	---	---
ADPRHL2	54936	broad.mit.edu	37	1	36557382	36557382	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36557382G>A	uc001bzt.2	+	3	525	c.472G>A	c.(472-474)GCT>ACT	p.A158T	ADPRHL2_uc001bzu.2_Missense_Mutation_p.A4T	NM_017825	NP_060295	Q9NX46	ARHL2_HUMAN	ADP-ribosylhydrolase like 2	158						cytoplasm|nucleus	metal ion binding|poly(ADP-ribose) glycohydrolase activity			pancreas(1)	1		Myeloproliferative disorder(586;0.0393)																---	---	---	---
C1orf113	79729	broad.mit.edu	37	1	36785329	36785329	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36785329G>A	uc010oia.1	+	14	1093	c.1065G>A	c.(1063-1065)ATG>ATA	p.M355I	C1orf113_uc010oib.1_Missense_Mutation_p.M244I|C1orf113_uc010oic.1_RNA|C1orf113_uc009vuz.1_Missense_Mutation_p.M1I	NM_001162530	NP_001156002	A4FU49	SH321_HUMAN	SH3 domain-containing protein C1orf113 isoform	239											0		Myeloproliferative disorder(586;0.0393)																---	---	---	---
ZC3H12A	80149	broad.mit.edu	37	1	37948726	37948726	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:37948726G>A	uc001cbb.3	+	6	1464	c.1314G>A	c.(1312-1314)TCG>TCA	p.S438S	ZC3H12A_uc001cbc.1_Silent_p.S233S	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	438					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)																---	---	---	---
INPP5B	3633	broad.mit.edu	37	1	38338648	38338648	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38338648A>G	uc001ccg.1	-	19	2235	c.2141T>C	c.(2140-2142)ATG>ACG	p.M714T	INPP5B_uc009vvk.1_Missense_Mutation_p.M655T|INPP5B_uc001ccf.1_Missense_Mutation_p.M550T	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	794					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)																---	---	---	---
KCNQ4	9132	broad.mit.edu	37	1	41250056	41250056	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:41250056G>T	uc001cgh.1	+	1	373	c.291G>T	c.(289-291)TGG>TGT	p.W97C	KCNQ4_uc001cgi.1_Missense_Mutation_p.W97C	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	97	Cytoplasmic.				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)															---	---	---	---
KCNQ4	9132	broad.mit.edu	37	1	41284205	41284205	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:41284205C>T	uc001cgh.1	+	4	643	c.561C>T	c.(559-561)GCC>GCT	p.A187A	KCNQ4_uc001cgi.1_Silent_p.A187A	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	187	Helical; Name=Segment S3; (Potential).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)															---	---	---	---
FOXJ3	22887	broad.mit.edu	37	1	42657107	42657107	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:42657107T>C	uc001che.2	-	11	1530	c.1218A>G	c.(1216-1218)CAA>CAG	p.Q406Q	FOXJ3_uc001chf.2_Silent_p.Q406Q|FOXJ3_uc001chg.2_Silent_p.Q406Q|FOXJ3_uc001chh.1_Silent_p.Q372Q	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	406					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)																---	---	---	---
WDR65	149465	broad.mit.edu	37	1	43664312	43664312	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43664312G>A	uc001cip.1	+	8	1544	c.1423G>A	c.(1423-1425)GGA>AGA	p.G475R	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Missense_Mutation_p.G464R|WDR65_uc001ciq.1_Missense_Mutation_p.G475R	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	475	WD 7.									skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
KIAA0467	23334	broad.mit.edu	37	1	43888980	43888980	+	5'UTR	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43888980C>T	uc001cjk.1	+	1					KIAA0467_uc009vws.1_Missense_Mutation_p.L750F	NM_015284	NP_056099			hypothetical protein LOC23334							peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
Unknown	0	broad.mit.edu	37	1	45287556	45287556	+	IGR	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45287556T>C								BTBD19 (7755 upstream) : PTCH2 (532 downstream)																																			---	---	---	---
EIF2B3	8891	broad.mit.edu	37	1	45407190	45407190	+	Missense_Mutation	SNP	T	C	C	rs151056457		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45407190T>C	uc001cmt.1	-	4	569	c.442A>G	c.(442-444)AAA>GAA	p.K148E	EIF2B3_uc001cmu.1_Missense_Mutation_p.K148E|EIF2B3_uc001cmv.1_Missense_Mutation_p.K148E|EIF2B3_uc001cmw.2_Missense_Mutation_p.K148E	NM_020365	NP_065098	Q9NR50	EI2BG_HUMAN	eukaryotic translation initiation factor 2B,	148					negative regulation of translational initiation in response to stress|oligodendrocyte development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	nucleotidyltransferase activity|protein binding|translation initiation factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
HECTD3	79654	broad.mit.edu	37	1	45472699	45472699	+	Intron	SNP	G	A	A	rs143819626	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45472699G>A	uc009vxk.2	-						HECTD3_uc001cmx.3_5'Flank|HECTD3_uc001cmy.3_Intron|HECTD3_uc010olh.1_Intron	NM_024602	NP_078878			HECT domain containing 3						proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
UROD	7389	broad.mit.edu	37	1	45480642	45480642	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45480642G>T	uc001cna.1	+	9	1014	c.906G>T	c.(904-906)CAG>CAT	p.Q302H	UROD_uc001cnb.1_Missense_Mutation_p.Q267H|UROD_uc001cnc.1_Missense_Mutation_p.Q207H	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	302						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)													Porphyria_Cutanea_Tarda_Type_II		OREG0013449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MMACHC	25974	broad.mit.edu	37	1	45973071	45973071	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45973071C>T	uc009vxv.2	+	2	274	c.125C>T	c.(124-126)CCG>CTG	p.P42L	MMACHC_uc001cny.2_RNA	NM_015506	NP_056321	Q9Y4U1	MMAC_HUMAN	methylmalonic aciduria (cobalamin deficiency)	42							cobalamin binding				0	Acute lymphoblastic leukemia(166;0.155)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
MAST2	23139	broad.mit.edu	37	1	46496962	46496962	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46496962G>T	uc001cov.2	+	23	3275	c.2992G>T	c.(2992-2994)GCT>TCT	p.A998S	MAST2_uc001cow.2_Missense_Mutation_p.A998S|MAST2_uc001coy.1_3'UTR|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	998					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)																	---	---	---	---
SPATA6	54558	broad.mit.edu	37	1	48771536	48771536	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:48771536T>C	uc001crr.1	-	12	1374	c.1209A>G	c.(1207-1209)CTA>CTG	p.L403L	SPATA6_uc001crs.1_Silent_p.L387L|SPATA6_uc010omv.1_Silent_p.L389L	NM_019073	NP_061946	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6 precursor	403					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				ovary(1)	1																		---	---	---	---
ZFYVE9	9372	broad.mit.edu	37	1	52729433	52729433	+	Intron	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52729433C>G	uc001cto.2	+						ZFYVE9_uc001ctn.2_Intron|ZFYVE9_uc001ctp.2_Intron	NM_004799	NP_004790			zinc finger, FYVE domain containing 9 isoform 3						endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8																		---	---	---	---
PDE4B	5142	broad.mit.edu	37	1	66834549	66834549	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:66834549G>A	uc001dcn.2	+	16	1933	c.1742G>A	c.(1741-1743)CGC>CAC	p.R581H	PDE4B_uc009war.2_Missense_Mutation_p.R489H|PDE4B_uc001dco.2_Missense_Mutation_p.R581H|PDE4B_uc001dcp.2_Missense_Mutation_p.R566H|PDE4B_uc001dcq.2_Missense_Mutation_p.R409H|PDE4B_uc009was.2_Missense_Mutation_p.R348H	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	581					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)													---	---	---	---
PTGFR	5737	broad.mit.edu	37	1	78958817	78958817	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78958817C>A	uc001din.2	+	2	655	c.389C>A	c.(388-390)GCC>GAC	p.A130D	PTGFR_uc001dim.2_Missense_Mutation_p.A130D	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	130	Helical; Name=3; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)													---	---	---	---
GBP6	163351	broad.mit.edu	37	1	89849285	89849285	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89849285C>T	uc001dnf.2	+	9	1714	c.1440C>T	c.(1438-1440)GCC>GCT	p.A480A	GBP6_uc010ost.1_Silent_p.A350A	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	480							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)														---	---	---	---
LRRC8D	55144	broad.mit.edu	37	1	90398726	90398726	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:90398726T>C	uc001dnm.2	+	3	524	c.99T>C	c.(97-99)GTT>GTC	p.V33V	LRRC8D_uc001dnn.2_Silent_p.V33V	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	33	Helical; (Potential).					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)														---	---	---	---
LRRC8D	55144	broad.mit.edu	37	1	90400443	90400443	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:90400443A>G	uc001dnm.2	+	3	2241	c.1816A>G	c.(1816-1818)ATT>GTT	p.I606V	LRRC8D_uc001dnn.2_Missense_Mutation_p.I606V	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	606	LRR 4.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)														---	---	---	---
EVI5	7813	broad.mit.edu	37	1	92979232	92979232	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:92979232G>A	uc001dox.2	-	18	2424	c.2414C>T	c.(2413-2415)TCG>TTG	p.S805L	EVI5_uc010otf.1_Missense_Mutation_p.S816L	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	805	Targeting to the centrosomes.|Interaction with AURKB and INCENP.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)														---	---	---	---
RPL5	6125	broad.mit.edu	37	1	93303108	93303108	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93303108T>C	uc001doz.2	+	6	701	c.623T>C	c.(622-624)ATG>ACG	p.M208T	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_RNA|RPL5_uc001dpb.2_Missense_Mutation_p.M158T|RPL5_uc001dpd.2_Missense_Mutation_p.M9T	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5	208					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)														---	---	---	---
CNN3	1266	broad.mit.edu	37	1	95368702	95368702	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:95368702G>A	uc010otw.1	-	4	304	c.222C>T	c.(220-222)AAC>AAT	p.N74N	CNN3_uc010otv.1_Silent_p.N33N|CNN3_uc001dqz.3_Silent_p.N74N|CNN3_uc010otx.1_Silent_p.N74N	NM_001839	NP_001830	Q15417	CNN3_HUMAN	calponin 3	74	CH.				actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)														---	---	---	---
PRMT6	55170	broad.mit.edu	37	1	107599519	107599519	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:107599519T>A	uc010ous.1	+	1	253	c.182T>A	c.(181-183)ATC>AAC	p.I61N		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	61					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity				0		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)														---	---	---	---
VAV3	10451	broad.mit.edu	37	1	108160177	108160177	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:108160177A>G	uc001dvk.1	-						VAV3_uc010ouu.1_Intron|VAV3_uc001dvj.1_Intron|VAV3_uc010ouv.1_Intron|VAV3_uc010ouw.1_Intron	NM_006113	NP_006104			vav 3 guanine nucleotide exchange factor isoform						angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)														---	---	---	---
VAV3	10451	broad.mit.edu	37	1	108303435	108303435	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:108303435G>A	uc001dvk.1	-	10	1042	c.988C>T	c.(988-990)CGT>TGT	p.R330C	VAV3_uc010ouw.1_Missense_Mutation_p.R330C|VAV3_uc001dvl.1_Missense_Mutation_p.R154C|VAV3_uc010oux.1_Missense_Mutation_p.R330C	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	330	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)														---	---	---	---
AMPD2	271	broad.mit.edu	37	1	110170866	110170866	+	Silent	SNP	C	T	T	rs114727970	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110170866C>T	uc009wfh.1	+	11	1946	c.1404C>T	c.(1402-1404)TAC>TAT	p.Y468Y	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Silent_p.Y387Y|AMPD2_uc001dyc.1_Silent_p.Y468Y|AMPD2_uc010ovr.1_Silent_p.Y393Y|AMPD2_uc010ovs.1_Silent_p.Y350Y|AMPD2_uc001dyd.1_Silent_p.Y349Y|AMPD2_uc001dye.1_5'Flank	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	468					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)														---	---	---	---
AMPD2	271	broad.mit.edu	37	1	110173650	110173650	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110173650G>A	uc009wfh.1	+	19	3058	c.2516G>A	c.(2515-2517)CGC>CAC	p.R839H	AMPD2_uc001dyb.1_Missense_Mutation_p.R758H|AMPD2_uc001dyc.1_Missense_Mutation_p.R839H|AMPD2_uc010ovr.1_Missense_Mutation_p.R764H|AMPD2_uc001dyd.1_Missense_Mutation_p.R720H|AMPD2_uc001dye.1_Missense_Mutation_p.R108H	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	839					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)														---	---	---	---
KCNA3	3738	broad.mit.edu	37	1	111217053	111217053	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111217053C>T	uc001dzv.1	-	1	603	c.379G>A	c.(379-381)GAG>AAG	p.E127K		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	127						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
CHIA	27159	broad.mit.edu	37	1	111857901	111857901	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111857901C>T	uc001eas.2	+	6	427	c.324C>T	c.(322-324)GCC>GCT	p.A108A	CHIA_uc001ear.2_5'UTR|CHIA_uc001eaq.2_5'UTR|CHIA_uc009wgc.2_5'UTR|CHIA_uc001eat.2_Intron|CHIA_uc001eav.2_5'UTR|CHIA_uc001eau.2_Intron|CHIA_uc009wgd.2_Intron	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	108					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)														---	---	---	---
DDX20	11218	broad.mit.edu	37	1	112305362	112305362	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:112305362T>C	uc001ebs.2	+	9	1525	c.1168T>C	c.(1168-1170)TGG>CGG	p.W390R	DDX20_uc010owf.1_Missense_Mutation_p.W152R|DDX20_uc001ebt.2_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	390	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
WNT2B	7482	broad.mit.edu	37	1	113033708	113033708	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113033708A>G	uc001eca.2	+						WNT2B_uc009wgg.2_Intron	NM_004185	NP_004176			wingless-type MMTV integration site family,						chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			ovary(2)|breast(2)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
PPM1J	333926	broad.mit.edu	37	1	113253204	113253204	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113253204C>T	uc001ect.1	-	9	1275	c.1248G>A	c.(1246-1248)GAG>GAA	p.E416E	PPM1J_uc009wgl.1_RNA|PPM1J_uc001ecs.1_Silent_p.E210E	NM_005167	NP_005158	Q5JR12	PPM1J_HUMAN	protein phosphatase 1J (PP2C domain containing)	416	PP2C-like.									breast(2)|central_nervous_system(1)	3	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
SYCP1	6847	broad.mit.edu	37	1	115456674	115456674	+	Intron	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115456674T>A	uc001efr.2	+						SYCP1_uc010owt.1_Intron|SYCP1_uc001efq.2_Intron|SYCP1_uc009wgw.2_Intron	NM_003176	NP_003167			synaptonemal complex protein 1						cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
VANGL1	81839	broad.mit.edu	37	1	116206712	116206712	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:116206712G>A	uc001efv.1	+	4	906	c.635G>A	c.(634-636)CGG>CAG	p.R212Q	VANGL1_uc009wgy.1_Missense_Mutation_p.R210Q|VANGL1_uc001efw.1_Missense_Mutation_p.R212Q	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	vang-like 1	212	Extracellular (Potential).				multicellular organismal development	integral to membrane	protein binding	p.R212W(1)		central_nervous_system(1)	1	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)														---	---	---	---
IGSF3	3321	broad.mit.edu	37	1	117122481	117122481	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117122481T>G	uc001egr.1	-	10	3572	c.2867A>C	c.(2866-2868)GAC>GCC	p.D956A	IGSF3_uc001egq.1_Missense_Mutation_p.D976A	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	956	Ig-like C2-type 8.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)														---	---	---	---
PPIAL4G	644591	broad.mit.edu	37	1	143767651	143767651	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:143767651G>A	uc001ejt.2	-	1	231	c.198C>T	c.(196-198)GAC>GAT	p.D66D		NM_001123068	NP_001116540	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like	66	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity				0																		---	---	---	---
PDE4DIP	9659	broad.mit.edu	37	1	145015864	145015864	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145015864T>C	uc001elx.3	-	3	559	c.224A>G	c.(223-225)GAG>GGG	p.E75G	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elm.3_5'UTR|PDE4DIP_uc001eln.3_Missense_Mutation_p.E75G|PDE4DIP_uc001elo.2_Missense_Mutation_p.E146G|PDE4DIP_uc001emh.2_Missense_Mutation_p.E146G|uc001emj.2_Intron	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)				T	PDGFRB	MPD								---	---	---	---
HIST2H3D	653604	broad.mit.edu	37	1	149784833	149784833	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:149784833C>T	uc010pbl.1	-	1	404	c.404G>A	c.(403-405)CGG>CAG	p.R135Q	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	135					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0																		---	---	---	---
LASS2	29956	broad.mit.edu	37	1	150940936	150940936	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150940936G>A	uc001evy.2	-	3	613	c.226C>T	c.(226-228)CTG>TTG	p.L76L	LASS2_uc001evz.2_Silent_p.L76L|LASS2_uc009wmh.2_5'UTR	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	76	Cytoplasmic (Potential).|Homeobox.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
ANXA9	8416	broad.mit.edu	37	1	150959137	150959137	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150959137G>T	uc001ewa.2	+	9	1082	c.612G>T	c.(610-612)CAG>CAT	p.Q204H		NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9	204	Annexin 3.				cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
FAM63A	55793	broad.mit.edu	37	1	150971889	150971889	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150971889C>T	uc001ewf.2	-	8	2621	c.937G>A	c.(937-939)GTC>ATC	p.V313I	FAM63A_uc001ewc.2_Missense_Mutation_p.V171I|FAM63A_uc010pcm.1_Missense_Mutation_p.V218I|FAM63A_uc001ewd.2_Missense_Mutation_p.V171I|FAM63A_uc001ewe.2_Missense_Mutation_p.V147I|FAM63A_uc010pcn.1_Missense_Mutation_p.V361I|FAM63A_uc001ewg.2_Missense_Mutation_p.V313I	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	313							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
PIP5K1A	8394	broad.mit.edu	37	1	151206963	151206963	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151206963T>C	uc001exj.2	+	8	1382	c.930T>C	c.(928-930)CGT>CGC	p.R310R	PIP5K1A_uc001exi.2_Silent_p.R297R|PIP5K1A_uc010pcu.1_Silent_p.R298R|PIP5K1A_uc001exk.2_Silent_p.R297R|PIP5K1A_uc010pcv.1_Silent_p.R67R	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	310	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
ZNF687	57592	broad.mit.edu	37	1	151259493	151259493	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151259493C>T	uc001exq.2	+	2	824	c.726C>T	c.(724-726)AGC>AGT	p.S242S	ZNF687_uc001exp.1_Silent_p.S251S|ZNF687_uc009wmo.2_Silent_p.S242S|ZNF687_uc009wmp.2_Silent_p.S242S	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	242	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
RORC	6097	broad.mit.edu	37	1	151785515	151785515	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151785515C>T	uc001ezh.2	-	9	1301	c.1193G>A	c.(1192-1194)AGC>AAC	p.S398N	RORC_uc001ezg.2_Missense_Mutation_p.S377N|RORC_uc010pdo.1_Missense_Mutation_p.S452N|RORC_uc010pdp.1_Missense_Mutation_p.S386N	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	398	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	154042791	154042791	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154042791T>C	uc001fdw.2	-	17	2584	c.2512A>G	c.(2512-2514)ATG>GTG	p.M838V	NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Missense_Mutation_p.M838V	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	838						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
ZBTB7B	51043	broad.mit.edu	37	1	154987838	154987838	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154987838G>T	uc001fgk.3	+	3	860	c.702G>T	c.(700-702)GAG>GAT	p.E234D	ZBTB7B_uc009wpa.2_Missense_Mutation_p.E234D|ZBTB7B_uc001fgj.3_Missense_Mutation_p.E268D|ZBTB7B_uc010peq.1_Missense_Mutation_p.E268D|ZBTB7B_uc001fgl.3_Missense_Mutation_p.E234D	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	234					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)															---	---	---	---
YY1AP1	55249	broad.mit.edu	37	1	155629928	155629928	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155629928G>A	uc001fln.2	-	11	1935	c.1911C>T	c.(1909-1911)GCC>GCT	p.A637A	YY1AP1_uc001flg.2_Silent_p.A376A|YY1AP1_uc010pgg.1_Silent_p.A476A|YY1AP1_uc010pgh.1_Silent_p.A580A|YY1AP1_uc010pgi.1_Silent_p.A729A|YY1AP1_uc001flh.2_Silent_p.A709A|YY1AP1_uc009wqt.2_Silent_p.A560A|YY1AP1_uc001flk.2_Silent_p.A580A|YY1AP1_uc001fll.2_Silent_p.A591A|YY1AP1_uc009wqv.2_Silent_p.A308A|YY1AP1_uc001flm.2_Silent_p.A580A|YY1AP1_uc001fli.2_Silent_p.A591A|YY1AP1_uc009wqu.2_Silent_p.A424A|YY1AP1_uc001flj.2_Silent_p.A571A|YY1AP1_uc009wqw.2_Silent_p.A560A|YY1AP1_uc001flo.2_Silent_p.A525A|YY1AP1_uc001flp.2_Silent_p.A591A	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	637					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)																	---	---	---	---
GON4L	54856	broad.mit.edu	37	1	155726824	155726824	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155726824C>T	uc001flz.2	-	27	5539	c.5442G>A	c.(5440-5442)GAG>GAA	p.E1814E	GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Silent_p.E1814E|GON4L_uc009wrh.1_Silent_p.E1814E|GON4L_uc001fma.1_Silent_p.E1814E|GON4L_uc001fmb.3_Silent_p.E1010E	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	1814					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)																	---	---	---	---
MEX3A	92312	broad.mit.edu	37	1	156047022	156047022	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156047022G>A	uc001fnd.3	-	2	906	c.906C>T	c.(904-906)AAC>AAT	p.N302N		NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	302						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)																	---	---	---	---
BCAN	63827	broad.mit.edu	37	1	156616629	156616629	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156616629C>T	uc001fpp.2	+	3	464	c.128C>T	c.(127-129)GCG>GTG	p.A43V	BCAN_uc001fpo.2_Missense_Mutation_p.A43V	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	43	Ig-like V-type.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
BCAN	63827	broad.mit.edu	37	1	156621265	156621265	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156621265G>A	uc001fpp.2	+	7	1417	c.1081G>A	c.(1081-1083)GCC>ACC	p.A361T	BCAN_uc001fpo.2_Missense_Mutation_p.A361T	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	361					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
NES	10763	broad.mit.edu	37	1	156641614	156641614	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156641614T>G	uc001fpq.2	-	4	2499	c.2366A>C	c.(2365-2367)AAG>ACG	p.K789T		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	789	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
INSRR	3645	broad.mit.edu	37	1	156821927	156821927	+	Missense_Mutation	SNP	C	T	T	rs140347940		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156821927C>T	uc010pht.1	-	3	948	c.694G>A	c.(694-696)GAA>AAA	p.E232K	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc009wsj.1_Missense_Mutation_p.E232K	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	232					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)																	---	---	---	---
FCRL5	83416	broad.mit.edu	37	1	157490795	157490795	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:157490795C>T	uc001fqu.2	-						FCRL5_uc009wsm.2_Intron	NM_031281	NP_112571			Fc receptor-like 5							integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)																---	---	---	---
CD5L	922	broad.mit.edu	37	1	157803265	157803265	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:157803265G>T	uc001frk.3	-	5	899	c.756C>A	c.(754-756)CTC>CTA	p.L252L		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	252	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)															---	---	---	---
KIRREL	55243	broad.mit.edu	37	1	158063221	158063221	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158063221C>T	uc001frn.3	+	12	1968	c.1564C>T	c.(1564-1566)CGG>TGG	p.R522W	KIRREL_uc010pib.1_Missense_Mutation_p.R422W|KIRREL_uc009wsq.2_Missense_Mutation_p.R358W|KIRREL_uc001fro.3_Missense_Mutation_p.R336W	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	522	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)																	---	---	---	---
CASQ1	844	broad.mit.edu	37	1	160165298	160165298	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160165298C>A	uc010pja.1	+	5	882	c.625C>A	c.(625-627)CCC>ACC	p.P209T		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	209						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
ARHGAP30	257106	broad.mit.edu	37	1	161026241	161026241	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161026241G>A	uc001fxl.2	-	3	628	c.282C>T	c.(280-282)TGC>TGT	p.C94C	ARHGAP30_uc001fxk.2_Silent_p.C94C|ARHGAP30_uc001fxm.2_Intron|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_5'UTR	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	94	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)															---	---	---	---
FCRLB	127943	broad.mit.edu	37	1	161697329	161697329	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161697329C>T	uc001gbh.2	+	8	1392	c.1158C>T	c.(1156-1158)AGC>AGT	p.S386S	FCRLB_uc009wus.2_Silent_p.S386S|FCRLB_uc001gbj.2_3'UTR|FCRLB_uc001gbk.2_3'UTR|FCRLB_uc001gbl.2_3'UTR|FCRLB_uc001gbm.2_3'UTR|FCRLB_uc001gbi.2_Silent_p.S386S|FCRLB_uc001gbn.3_3'UTR	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	386						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)															---	---	---	---
PBX1	5087	broad.mit.edu	37	1	164768972	164768972	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:164768972C>A	uc001gct.2	+	4	805	c.547C>A	c.(547-549)CTG>ATG	p.L183M	PBX1_uc010pku.1_Missense_Mutation_p.L183M|PBX1_uc010pkv.1_Missense_Mutation_p.L100M|PBX1_uc001gcs.2_Missense_Mutation_p.L183M|PBX1_uc010pkw.1_Missense_Mutation_p.L73M	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	183					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5								T	TCF3|EWSR1	pre B-ALL|myoepithelioma								---	---	---	---
LMX1A	4009	broad.mit.edu	37	1	165182974	165182974	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:165182974G>A	uc001gcy.1	-	4	794	c.573C>T	c.(571-573)GAC>GAT	p.D191D	LMX1A_uc001gcz.1_Silent_p.D191D|LMX1A_uc001gcw.1_5'Flank|LMX1A_uc001gcx.1_5'Flank	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	191						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)																	---	---	---	---
GPA33	10223	broad.mit.edu	37	1	167024259	167024259	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167024259A>G	uc001gea.1	-	6	1125	c.781T>C	c.(781-783)TGC>CGC	p.C261R		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	261	Cytoplasmic (Potential).|Poly-Cys.					integral to plasma membrane	receptor activity				0																		---	---	---	---
ADCY10	55811	broad.mit.edu	37	1	167792355	167792355	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167792355C>T	uc001ger.2	-	29	4357	c.4059G>A	c.(4057-4059)CCG>CCA	p.P1353P	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Silent_p.P1261P|ADCY10_uc010plj.1_Silent_p.P1200P	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1353					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
GPR161	23432	broad.mit.edu	37	1	168054846	168054846	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:168054846T>C	uc001gfc.2	-	8	1827	c.1513A>G	c.(1513-1515)AGC>GGC	p.S505G	GPR161_uc001gfb.2_Missense_Mutation_p.S373G|GPR161_uc010pll.1_Missense_Mutation_p.S415G|GPR161_uc010plm.1_Missense_Mutation_p.S391G|GPR161_uc009wvo.2_Missense_Mutation_p.S522G|GPR161_uc001gfd.2_Missense_Mutation_p.S505G|GPR161_uc010pln.1_Missense_Mutation_p.S525G	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	505	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)																	---	---	---	---
TNR	7143	broad.mit.edu	37	1	175372559	175372559	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175372559G>A	uc001gkp.1	-	2	774	c.693C>T	c.(691-693)TCC>TCT	p.S231S	TNR_uc009wwu.1_Silent_p.S231S|TNR_uc010pmz.1_Silent_p.S231S	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	231	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)																	---	---	---	---
PAPPA2	60676	broad.mit.edu	37	1	176525653	176525653	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176525653T>G	uc001gkz.2	+	2	1359	c.195T>G	c.(193-195)CAT>CAG	p.H65Q	PAPPA2_uc001gky.1_Missense_Mutation_p.H65Q|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	65					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16																		---	---	---	---
PAPPA2	60676	broad.mit.edu	37	1	176659457	176659457	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176659457C>T	uc001gkz.2	+	5	3486	c.2322C>T	c.(2320-2322)ACC>ACT	p.T774T	PAPPA2_uc001gky.1_Silent_p.T774T|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	774					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16																		---	---	---	---
ASTN1	460	broad.mit.edu	37	1	177001708	177001708	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:177001708C>T	uc001glc.2	-	3	961	c.749G>A	c.(748-750)CGC>CAC	p.R250H	ASTN1_uc001glb.1_Missense_Mutation_p.R250H|ASTN1_uc001gld.1_Missense_Mutation_p.R250H|ASTN1_uc009wwx.1_Missense_Mutation_p.R250H|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	250					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15																		---	---	---	---
LHX4	89884	broad.mit.edu	37	1	180243505	180243505	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:180243505T>C	uc001goe.1	+	6	1187	c.964T>C	c.(964-966)TCC>CCC	p.S322P	uc001gof.1_Intron	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	322						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
MR1	3140	broad.mit.edu	37	1	181018395	181018395	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:181018395A>G	uc001goq.1	+	2	280	c.275A>G	c.(274-276)CAG>CGG	p.Q92R	MR1_uc001gop.2_Missense_Mutation_p.Q92R|MR1_uc001gor.1_Missense_Mutation_p.Q92R|MR1_uc001gos.1_Missense_Mutation_p.Q92R|MR1_uc010pns.1_Missense_Mutation_p.Q92R	NM_001531	NP_001522	Q95460	HMR1_HUMAN	major histocompatibility complex, class	92	Extracellular (Potential).|Ligand-binding.|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			skin(1)	1																		---	---	---	---
RNASEL	6041	broad.mit.edu	37	1	182555837	182555837	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:182555837G>A	uc001gpj.1	-	1	272	c.105C>T	c.(103-105)AAC>AAT	p.N35N	RNASEL_uc009wxz.1_Silent_p.N35N|RNASEL_uc001gpk.2_Silent_p.N35N|RNASEL_uc009wya.1_Silent_p.N35N	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	35	ANK 1.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5														Hereditary_Prostate_Cancer				---	---	---	---
GLT25D2	23127	broad.mit.edu	37	1	183920195	183920195	+	Missense_Mutation	SNP	C	T	T	rs150214481		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:183920195C>T	uc001gqr.2	-	8	1454	c.1082G>A	c.(1081-1083)CGC>CAC	p.R361H	GLT25D2_uc010poj.1_Missense_Mutation_p.R361H|GLT25D2_uc001gqq.2_Missense_Mutation_p.R98H|GLT25D2_uc001gqs.2_Missense_Mutation_p.R241H	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	361					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	185962394	185962394	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:185962394C>T	uc001grq.1	+	23	3687	c.3458C>T	c.(3457-3459)ACA>ATA	p.T1153I	HMCN1_uc001grr.1_Missense_Mutation_p.T494I	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1153	Ig-like C2-type 8.			T -> I (in Ref. 2; BAB71216).	response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186114613	186114613	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186114613G>A	uc001grq.1	+	92	14574	c.14345G>A	c.(14344-14346)CGC>CAC	p.R4782H	HMCN1_uc001grs.1_Missense_Mutation_p.R351H	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4782	TSP type-1 5.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
FAM5C	339479	broad.mit.edu	37	1	190067293	190067293	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:190067293C>T	uc001gse.1	-	8	2388	c.2156G>A	c.(2155-2157)CGT>CAT	p.R719H	FAM5C_uc010pot.1_Missense_Mutation_p.R617H	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	719						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)																	---	---	---	---
CDC73	79577	broad.mit.edu	37	1	193205392	193205392	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:193205392C>T	uc001gtb.2	+	15	1566	c.1323C>T	c.(1321-1323)CGC>CGT	p.R441R		NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	441					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49														Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome				---	---	---	---
CFH	3075	broad.mit.edu	37	1	196706662	196706662	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196706662G>T	uc001gtj.3	+	17	2894	c.2654G>T	c.(2653-2655)AGG>ATG	p.R885M		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	885	Sushi 15.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6																		---	---	---	---
ZNF281	23528	broad.mit.edu	37	1	200377909	200377909	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200377909T>G	uc001gve.2	-	2	1032	c.925A>C	c.(925-927)AAA>CAA	p.K309Q	ZNF281_uc001gvf.1_Missense_Mutation_p.K309Q|ZNF281_uc001gvg.1_Missense_Mutation_p.K273Q	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	309	C2H2-type 2.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2																		---	---	---	---
DDX59	83479	broad.mit.edu	37	1	200635401	200635401	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200635401A>G	uc009wzk.2	-	2	711	c.468T>C	c.(466-468)TCT>TCC	p.S156S	DDX59_uc010ppl.1_Silent_p.S156S	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	156						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
LAD1	3898	broad.mit.edu	37	1	201356058	201356058	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201356058C>T	uc001gwm.2	-	3	666	c.431G>A	c.(430-432)CGG>CAG	p.R144Q	LAD1_uc009wzu.1_Missense_Mutation_p.R166Q	NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	144						basement membrane	structural molecule activity				0																		---	---	---	---
KDM5B	10765	broad.mit.edu	37	1	202722105	202722105	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202722105C>T	uc001gyf.2	-	12	1745	c.1629G>A	c.(1627-1629)GTG>GTA	p.V543V	KDM5B_uc009xag.2_Silent_p.V579V|KDM5B_uc001gyg.1_Silent_p.V385V	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	543	JmjC.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5																		---	---	---	---
MDM4	4194	broad.mit.edu	37	1	204518448	204518448	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204518448G>A	uc001hba.2	+	11	1273	c.1111G>A	c.(1111-1113)GTT>ATT	p.V371I	MDM4_uc001hbd.1_RNA|MDM4_uc010pqw.1_RNA|MDM4_uc010pqx.1_Missense_Mutation_p.V244I|MDM4_uc001hay.1_Missense_Mutation_p.V321I|MDM4_uc001hbb.2_Missense_Mutation_p.V244I|MDM4_uc010pqy.1_Intron|MDM4_uc001hbc.2_RNA|MDM4_uc009xbe.1_RNA	NM_002393	NP_002384	O15151	MDM4_HUMAN	mouse double minute 4 homolog	371					apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)					A		GBM|bladder|retinoblastoma								---	---	---	---
CNTN2	6900	broad.mit.edu	37	1	205031109	205031109	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205031109G>A	uc001hbr.2	+	9	1359	c.1090G>A	c.(1090-1092)GGG>AGG	p.G364R	CNTN2_uc001hbq.1_Missense_Mutation_p.G255R|CNTN2_uc009xbi.2_Missense_Mutation_p.G255R|CNTN2_uc001hbs.2_Missense_Mutation_p.G152R	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	364	Ig-like C2-type 4.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)													OREG0014144	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TMEM81	388730	broad.mit.edu	37	1	205053001	205053001	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205053001C>T	uc001hbt.2	-	1	588	c.448G>A	c.(448-450)GCT>ACT	p.A150T		NM_203376	NP_976310	Q6P7N7	TMM81_HUMAN	transmembrane protein 81 precursor	150	Ig-like.|Extracellular (Potential).					integral to membrane					0	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)															---	---	---	---
PIGR	5284	broad.mit.edu	37	1	207111045	207111045	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207111045G>A	uc001hez.2	-	4	624	c.440C>T	c.(439-441)ACG>ATG	p.T147M	PIGR_uc009xbz.2_Missense_Mutation_p.T147M	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	147	Ig-like V-type 2.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
CR1	1378	broad.mit.edu	37	1	207787753	207787753	+	Nonsense_Mutation	SNP	C	T	T	rs55749440		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207787753C>T	uc001hfy.2	+	32	5370	c.5230C>T	c.(5230-5232)CGA>TGA	p.R1744*	CR1_uc001hfx.2_Nonsense_Mutation_p.R2194*	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1744	Extracellular (Potential).|Sushi 27.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3																		---	---	---	---
CR1	1378	broad.mit.edu	37	1	207787831	207787831	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207787831G>T	uc001hfy.2	+	32	5448	c.5308G>T	c.(5308-5310)GAA>TAA	p.E1770*	CR1_uc001hfx.2_Nonsense_Mutation_p.E2220*	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1770	Extracellular (Potential).|Sushi 27.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3																		---	---	---	---
LAMB3	3914	broad.mit.edu	37	1	209803987	209803987	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209803987C>T	uc001hhg.2	-	8	1306	c.916G>A	c.(916-918)GAG>AAG	p.E306K	LAMB3_uc009xco.2_Missense_Mutation_p.E306K|LAMB3_uc001hhh.2_Missense_Mutation_p.E306K|LAMB3_uc010psl.1_RNA|LAMB3_uc009xcp.1_Missense_Mutation_p.E242K	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	306	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)														---	---	---	---
HHAT	55733	broad.mit.edu	37	1	210637863	210637863	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:210637863G>A	uc009xcx.2	+	8	1037	c.871G>A	c.(871-873)GCC>ACC	p.A291T	HHAT_uc010psq.1_Missense_Mutation_p.A154T|HHAT_uc001hhz.3_Missense_Mutation_p.A291T|HHAT_uc010psr.1_Missense_Mutation_p.A292T|HHAT_uc010pss.1_Missense_Mutation_p.A246T|HHAT_uc009xcy.2_Missense_Mutation_p.A226T|HHAT_uc010pst.1_Missense_Mutation_p.A228T|HHAT_uc010psu.1_Missense_Mutation_p.A226T|HHAT_uc001hia.3_5'UTR	NM_001122834	NP_001116306	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	291	Helical; (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)														---	---	---	---
RCOR3	55758	broad.mit.edu	37	1	211444604	211444604	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:211444604G>T	uc001hig.2	+	2	249	c.80G>T	c.(79-81)GGA>GTA	p.G27V	RCOR3_uc010psv.1_RNA|RCOR3_uc001hie.2_Missense_Mutation_p.G85V|RCOR3_uc010psw.1_Missense_Mutation_p.G85V|RCOR3_uc001hif.2_Missense_Mutation_p.G85V	NM_018254	NP_060724	Q9P2K3	RCOR3_HUMAN	REST corepressor 3 isoform d	27	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)														---	---	---	---
RPS6KC1	26750	broad.mit.edu	37	1	213445950	213445950	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:213445950T>C	uc010ptr.1	+	15	3333	c.3174T>C	c.(3172-3174)CCT>CCC	p.P1058P	RPS6KC1_uc001hkd.2_Silent_p.P1046P|RPS6KC1_uc010pts.1_Silent_p.P846P|RPS6KC1_uc010ptt.1_Silent_p.P846P|RPS6KC1_uc010ptu.1_Silent_p.P877P|RPS6KC1_uc010ptv.1_Silent_p.P593P|RPS6KC1_uc001hke.2_Silent_p.P877P	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	1058					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)														---	---	---	---
PTPN14	5784	broad.mit.edu	37	1	214638039	214638039	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:214638039C>T	uc001hkk.1	-	2	379	c.108G>A	c.(106-108)ACG>ACA	p.T36T	PTPN14_uc010pty.1_Intron	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	36	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)														---	---	---	---
ESRRG	2104	broad.mit.edu	37	1	216850489	216850489	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:216850489A>G	uc001hkw.1	-	2	567	c.401T>C	c.(400-402)ATC>ACC	p.I134T	ESRRG_uc001hky.1_Missense_Mutation_p.I111T|ESRRG_uc009xdp.1_Missense_Mutation_p.I111T|ESRRG_uc001hkz.1_Missense_Mutation_p.I111T|ESRRG_uc010puc.1_Missense_Mutation_p.I111T|ESRRG_uc001hla.1_Missense_Mutation_p.I111T|ESRRG_uc001hlb.1_Missense_Mutation_p.I111T|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Missense_Mutation_p.I111T|ESRRG_uc001hld.1_Missense_Mutation_p.I111T|ESRRG_uc001hkx.1_Missense_Mutation_p.I139T|ESRRG_uc009xdo.1_Missense_Mutation_p.I111T|ESRRG_uc001hle.1_Missense_Mutation_p.I111T	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	134	Nuclear receptor.|NR C4-type.				positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)													---	---	---	---
DISP1	84976	broad.mit.edu	37	1	223176686	223176686	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223176686C>T	uc001hnu.1	+	8	2094	c.1947C>T	c.(1945-1947)GTC>GTT	p.V649V		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	649	Helical; (Potential).|SSD.				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)														---	---	---	---
DISP1	84976	broad.mit.edu	37	1	223178672	223178672	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223178672C>T	uc001hnu.1	+	8	4080	c.3933C>T	c.(3931-3933)GGC>GGT	p.G1311G		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1311					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)														---	---	---	---
SUSD4	55061	broad.mit.edu	37	1	223465929	223465929	+	Silent	SNP	G	A	A	rs148470082		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223465929G>A	uc001hnx.2	-	2	847	c.213C>T	c.(211-213)AGC>AGT	p.S71S	SUSD4_uc001hny.3_Silent_p.S71S|SUSD4_uc010puw.1_5'UTR|SUSD4_uc001hnz.2_Silent_p.S71S|SUSD4_uc010pux.1_Intron	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	71	Sushi 1.|Extracellular (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)														---	---	---	---
CABC1	56997	broad.mit.edu	37	1	227171262	227171262	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:227171262G>A	uc001hqm.1	+	14	4509	c.1090G>A	c.(1090-1092)GTG>ATG	p.V364M	CABC1_uc001hqn.1_Missense_Mutation_p.V364M|CABC1_uc009xeq.1_Missense_Mutation_p.V312M|CABC1_uc010pvq.1_Missense_Mutation_p.V85M|CABC1_uc010pvr.1_Missense_Mutation_p.V38M|CABC1_uc001hqo.1_Missense_Mutation_p.V85M|CABC1_uc009xer.1_Translation_Start_Site	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	364	Protein kinase.				cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228466971	228466971	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228466971C>T	uc009xez.1	+	27	7266	c.7222C>T	c.(7222-7224)CGG>TGG	p.R2408W	OBSCN_uc001hsn.2_Missense_Mutation_p.R2408W|OBSCN_uc001hsp.1_Missense_Mutation_p.R107W|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2408					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228495060	228495060	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228495060C>T	uc009xez.1	+	46	12338	c.12294C>T	c.(12292-12294)GCC>GCT	p.A4098A	OBSCN_uc001hsn.2_Silent_p.A4098A	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4098	Ig-like 42.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
ACTA1	58	broad.mit.edu	37	1	229568041	229568041	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229568041G>A	uc001htm.2	-	4	697	c.592C>T	c.(592-594)CGT>TGT	p.R198C		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	198			R -> L (in NEM3).		muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)													---	---	---	---
URB2	9816	broad.mit.edu	37	1	229772467	229772467	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229772467G>A	uc001hts.1	+	4	2243	c.2107G>A	c.(2107-2109)GAT>AAT	p.D703N	URB2_uc009xfd.1_Missense_Mutation_p.D703N	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	703						nucleolus				central_nervous_system(2)|ovary(1)	3																		---	---	---	---
SIPA1L2	57568	broad.mit.edu	37	1	232649957	232649957	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:232649957A>G	uc001hvg.2	-	1	1287	c.1129T>C	c.(1129-1131)TGT>CGT	p.C377R		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	377					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)																---	---	---	---
LYST	1130	broad.mit.edu	37	1	235918953	235918953	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235918953C>T	uc001hxj.2	-						LYST_uc009xga.1_5'Flank	NM_000081	NP_000072			lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237777646	237777646	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237777646C>T	uc001hyl.1	+	37	5338	c.5218C>T	c.(5218-5220)CCT>TCT	p.P1740S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1740	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237886423	237886423	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237886423T>C	uc001hyl.1	+						RYR2_uc010pxz.1_Intron	NM_001035	NP_001026			cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
ZNF238	10472	broad.mit.edu	37	1	244218598	244218598	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:244218598A>G	uc001iae.2	+	1	2017	c.1495A>G	c.(1495-1497)AAA>GAA	p.K499E	ZNF238_uc001iad.3_Missense_Mutation_p.K508E|ZNF238_uc001iaf.1_3'UTR	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	499					negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)															---	---	---	---
OR2B11	127623	broad.mit.edu	37	1	247614857	247614857	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247614857G>A	uc010pyx.1	-	1	428	c.428C>T	c.(427-429)GCT>GTT	p.A143V		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	143	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)															---	---	---	---
OR2W5	441932	broad.mit.edu	37	1	247654874	247654874	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247654874T>C	uc001icz.1	+	1	445	c.445T>C	c.(445-447)TGG>CGG	p.W149R		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)															---	---	---	---
TSSC1	7260	broad.mit.edu	37	2	3261132	3261132	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:3261132G>A	uc002qxj.2	-	4	547	c.354C>T	c.(352-354)AGC>AGT	p.S118S	TSSC1_uc002qxi.2_RNA	NM_003310	NP_003301	Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	118							protein binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)														---	---	---	---
ASAP2	8853	broad.mit.edu	37	2	9491025	9491025	+	Splice_Site	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:9491025G>A	uc002qzh.2	+	12	1451	c.1111_splice	c.e12+1	p.H371_splice	ASAP2_uc002qzi.2_Splice_Site_p.H371_splice	NM_003887	NP_003878			ArfGAP with SH3 domain, ankyrin repeat and PH						regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0																		---	---	---	---
TAF1B	9014	broad.mit.edu	37	2	10045054	10045054	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10045054C>T	uc002qzz.2	+	9	974	c.874C>T	c.(874-876)CGT>TGT	p.R292C	TAF1B_uc010exc.2_Missense_Mutation_p.R292C|TAF1B_uc002qzy.3_Missense_Mutation_p.R292C|TAF1B_uc010yja.1_Missense_Mutation_p.R37C|TAF1B_uc010exd.2_Missense_Mutation_p.R37C	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	292					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
RAD51AP2	729475	broad.mit.edu	37	2	17696566	17696566	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:17696566A>G	uc002rcl.1	-	1	3141	c.3117T>C	c.(3115-3117)AAT>AAC	p.N1039N	RAD51AP2_uc010exn.1_Silent_p.N1030N	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	1039										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)																	---	---	---	---
MSGN1	343930	broad.mit.edu	37	2	17997959	17997959	+	Silent	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:17997959T>G	uc010yjt.1	+	1	174	c.174T>G	c.(172-174)TCT>TCG	p.S58S		NM_001105569	NP_001099039	A6NI15	MSGN1_HUMAN	mesogenin 1	58					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)																	---	---	---	---
NT5C1B	93034	broad.mit.edu	37	2	18765855	18765855	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:18765855G>A	uc002rcz.2	-	5	932	c.828C>T	c.(826-828)GAC>GAT	p.D276D	NT5C1B_uc002rcy.2_Silent_p.D276D|NT5C1B_uc010exr.2_Silent_p.D218D|NT5C1B_uc010yju.1_Silent_p.D216D|NT5C1B_uc002rda.2_Silent_p.D216D|NT5C1B_uc010yjv.1_Silent_p.D293D|NT5C1B_uc010yjw.1_Silent_p.D259D|NT5C1B_uc010exs.2_Silent_p.D278D|NT5C1B_uc002rdb.1_Silent_p.D68D	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	276					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)																---	---	---	---
NCOA1	8648	broad.mit.edu	37	2	24929854	24929854	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24929854C>T	uc002rfk.2	+	11	1773	c.1515C>T	c.(1513-1515)AAC>AAT	p.N505N	NCOA1_uc010eye.2_Silent_p.N505N|NCOA1_uc002rfi.2_Silent_p.N354N|NCOA1_uc002rfj.2_Silent_p.N505N|NCOA1_uc002rfl.2_Silent_p.N505N	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	505	Interaction with STAT3.|Ser-rich.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)							T	PAX3	alveolar rhadomyosarcoma								---	---	---	---
NCOA1	8648	broad.mit.edu	37	2	24974860	24974860	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24974860C>T	uc002rfk.2	+	18	3974	c.3716C>T	c.(3715-3717)CCC>CTC	p.P1239L	NCOA1_uc010eye.2_Missense_Mutation_p.P1239L|NCOA1_uc002rfi.2_Missense_Mutation_p.P1088L|NCOA1_uc002rfj.2_Missense_Mutation_p.P1239L|NCOA1_uc002rfl.2_Missense_Mutation_p.P1239L|NCOA1_uc010eyf.2_Missense_Mutation_p.P132L	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	1239									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)							T	PAX3	alveolar rhadomyosarcoma								---	---	---	---
ASXL2	55252	broad.mit.edu	37	2	25964955	25964955	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25964955G>A	uc002rgs.2	-	12	4472	c.4251C>T	c.(4249-4251)TGC>TGT	p.C1417C	ASXL2_uc002rgt.1_Silent_p.C900C	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	1417	PHD-type; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
AGBL5	60509	broad.mit.edu	37	2	27282344	27282344	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27282344G>A	uc002rie.2	+						AGBL5_uc002rid.2_3'UTR|AGBL5_uc002rif.2_Intron	NM_021831	NP_068603			ATP/GTP binding protein-like 5 isoform 1						protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
SLC5A6	8884	broad.mit.edu	37	2	27423438	27423438	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27423438C>T	uc002rjd.2	-	17	2165	c.1774G>A	c.(1774-1776)GAC>AAC	p.D592N	SLC5A6_uc010eyv.1_Missense_Mutation_p.D592N	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	592					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)													---	---	---	---
EIF2B4	8890	broad.mit.edu	37	2	27590038	27590038	+	Missense_Mutation	SNP	G	A	A	rs78599355	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27590038G>A	uc002rkb.2	-	10	1059	c.916C>T	c.(916-918)CGG>TGG	p.R306W	EIF2B4_uc002rjz.2_Missense_Mutation_p.R326W|EIF2B4_uc002rka.2_Missense_Mutation_p.R291W|EIF2B4_uc002rkc.2_Missense_Mutation_p.R305W|EIF2B4_uc002rkd.2_Missense_Mutation_p.R100W|EIF2B4_uc002rke.2_Missense_Mutation_p.R275W|EIF2B4_uc002rkf.1_3'UTR	NM_001034116	NP_001029288	Q9UI10	EI2BD_HUMAN	eukaryotic translation initiation factor 2B,	306			R -> G.		myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	translation initiation factor activity|translation initiation factor binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
ZNF513	130557	broad.mit.edu	37	2	27601323	27601323	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27601323G>A	uc002rkk.2	-						ZNF513_uc002rkj.2_Intron	NM_144631	NP_653232			zinc finger protein 513						regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
FOSL2	2355	broad.mit.edu	37	2	28631709	28631709	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:28631709G>T	uc002rma.2	+	3	1247	c.438G>T	c.(436-438)CGG>CGT	p.R146R	FOSL2_uc010ymi.1_Silent_p.R107R	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	146	Basic motif.				cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32800338	32800338	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32800338T>C	uc010ezu.2	+	66	13394	c.13260T>C	c.(13258-13260)GGT>GGC	p.G4420G		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4420					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
VIT	5212	broad.mit.edu	37	2	37035765	37035765	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37035765G>A	uc002rpl.2	+	15	1761	c.1540G>A	c.(1540-1542)GTC>ATC	p.V514I	VIT_uc002rpm.2_Missense_Mutation_p.V492I|VIT_uc010ezv.2_Missense_Mutation_p.V470I|VIT_uc010ezw.2_Missense_Mutation_p.V471I	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	499	VWFA 2.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)																---	---	---	---
STRN	6801	broad.mit.edu	37	2	37129804	37129804	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37129804C>T	uc002rpn.2	-	5	591	c.582G>A	c.(580-582)ACG>ACA	p.T194T	STRN_uc010ezx.2_Silent_p.T194T	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	194					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)																---	---	---	---
EIF2AK2	5610	broad.mit.edu	37	2	37334430	37334430	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37334430G>A	uc010ynh.1	-	17	2199	c.1642C>T	c.(1642-1644)CGA>TGA	p.R548*	EIF2AK2_uc010fab.1_Nonsense_Mutation_p.R507*|EIF2AK2_uc010yng.1_Nonsense_Mutation_p.R505*|EIF2AK2_uc010fac.2_Nonsense_Mutation_p.R548*	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	548					evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)																---	---	---	---
CEBPZ	10153	broad.mit.edu	37	2	37454928	37454928	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37454928G>A	uc002rpz.2	-	2	1438	c.1408C>T	c.(1408-1410)CGG>TGG	p.R470W		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	470					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)																---	---	---	---
EML4	27436	broad.mit.edu	37	2	42515473	42515473	+	Intron	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:42515473A>T	uc002rsi.2	+						EML4_uc010fap.2_Intron|EML4_uc002rsj.2_Intron	NM_019063	NP_061936			echinoderm microtubule associated protein like 4						microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250								T	ALK	NSCLC								---	---	---	---
TSPYL6	388951	broad.mit.edu	37	2	54483258	54483258	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54483258C>T	uc002rxr.2	-	1	152	c.31G>A	c.(31-33)GCT>ACT	p.A11T	ACYP2_uc002rxq.3_Intron	NM_001003937	NP_001003937	Q8N831	TSYL6_HUMAN	TSPY-like 6	11					nucleosome assembly	nucleus					0																		---	---	---	---
SPTBN1	6711	broad.mit.edu	37	2	54877104	54877104	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54877104A>T	uc002rxu.2	+	26	5804	c.5555A>T	c.(5554-5556)GAC>GTC	p.D1852V	SPTBN1_uc002rxx.2_Missense_Mutation_p.D1839V|SPTBN1_uc002rxy.2_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1852	Interaction with ANK2.|Spectrin 15.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)															---	---	---	---
C2orf86	51057	broad.mit.edu	37	2	63540407	63540407	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:63540407G>A	uc002sch.2	-	13	2234	c.1788C>T	c.(1786-1788)GAC>GAT	p.D596D	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Silent_p.D437D|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Silent_p.D404D	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	596					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0																		---	---	---	---
MDH1	4190	broad.mit.edu	37	2	63824675	63824675	+	Silent	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:63824675A>C	uc002scj.1	+	4	398	c.342A>C	c.(340-342)GCA>GCC	p.A114A	MDH1_uc010ypv.1_Silent_p.A132A|MDH1_uc010ypw.1_Silent_p.A19A	NM_005917	NP_005908	P40925	MDHC_HUMAN	cytosolic malate dehydrogenase	114					gluconeogenesis|tricarboxylic acid cycle	centrosome|cytosol	L-malate dehydrogenase activity|malic enzyme activity			kidney(2)	2					NADH(DB00157)													---	---	---	---
RAB1A	5861	broad.mit.edu	37	2	65341290	65341290	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:65341290A>G	uc002sdm.2	-						RAB1A_uc002sdn.2_Intron|RAB1A_uc010yqe.1_Intron|RAB1A_uc002sdo.2_Intron	NM_004161	NP_004152			RAB1A, member RAS oncogene family isoform 1						protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	GTP binding|GTPase activity				0																		---	---	---	---
ARHGAP25	9938	broad.mit.edu	37	2	69045039	69045039	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:69045039A>G	uc002seu.2	+	8	1277	c.913A>G	c.(913-915)AAC>GAC	p.N305D	ARHGAP25_uc010fdg.2_Missense_Mutation_p.N306D|ARHGAP25_uc010yql.1_Missense_Mutation_p.N266D|ARHGAP25_uc002sev.2_Missense_Mutation_p.N299D|ARHGAP25_uc002sew.2_Missense_Mutation_p.N298D|ARHGAP25_uc002sex.2_Missense_Mutation_p.N299D|ARHGAP25_uc010fdh.1_RNA|ARHGAP25_uc002sey.2_Missense_Mutation_p.N32D	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	305	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4																		---	---	---	---
CYP26B1	56603	broad.mit.edu	37	2	72362528	72362528	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:72362528G>A	uc002sih.1	-	3	450	c.450C>T	c.(448-450)AGC>AGT	p.S150S	CYP26B1_uc010yra.1_Silent_p.S133S|CYP26B1_uc010yrb.1_Silent_p.S75S	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	150					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2																		---	---	---	---
EGR4	1961	broad.mit.edu	37	2	73518651	73518651	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73518651C>T	uc010yrj.1	-	2	1779	c.1704G>A	c.(1702-1704)GCG>GCA	p.A568A	EGR4_uc010yrk.1_Silent_p.A567A	NM_001965	NP_001956	Q05215	EGR4_HUMAN	early growth response 4	464						intracellular	nucleic acid binding|zinc ion binding				0																		---	---	---	---
C2orf78	388960	broad.mit.edu	37	2	74043913	74043913	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74043913C>T	uc002sjr.1	+	3	2684	c.2563C>T	c.(2563-2565)CGT>TGT	p.R855C		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	855										ovary(2)	2																		---	---	---	---
CTNNA2	1496	broad.mit.edu	37	2	80136908	80136908	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:80136908C>T	uc010ysh.1	+	6	1046	c.1041C>T	c.(1039-1041)AGC>AGT	p.S347S	CTNNA2_uc010yse.1_Silent_p.S347S|CTNNA2_uc010ysf.1_Silent_p.S347S|CTNNA2_uc010ysg.1_Silent_p.S347S	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	347					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9																		---	---	---	---
SFTPB	6439	broad.mit.edu	37	2	85890587	85890587	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85890587C>T	uc002sqh.2	-	8	890	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	SFTPB_uc002sqi.2_Missense_Mutation_p.R303Q|SFTPB_uc002sqj.2_Missense_Mutation_p.R295Q|SFTPB_uc010ysw.1_5'Flank	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	295	Saposin B-type 3.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
SFTPB	6439	broad.mit.edu	37	2	85894899	85894899	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85894899G>C	uc002sqh.2	-	2	104	c.98C>G	c.(97-99)GCC>GGC	p.A33G	SFTPB_uc002sqi.2_Missense_Mutation_p.A45G|SFTPB_uc002sqj.2_Missense_Mutation_p.A33G	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	33	Saposin A-type.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
POLR1A	25885	broad.mit.edu	37	2	86292506	86292506	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86292506C>T	uc002sqs.2	-	14	2328	c.1949G>A	c.(1948-1950)CGG>CAG	p.R650Q	POLR1A_uc010ytb.1_Missense_Mutation_p.R16Q	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	650					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
TEKT4	150483	broad.mit.edu	37	2	95539788	95539788	+	Silent	SNP	C	T	T	rs147190189		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95539788C>T	uc002stw.1	+	3	741	c.648C>T	c.(646-648)TGC>TGT	p.C216C	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	216					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
SNRNP200	23020	broad.mit.edu	37	2	96944058	96944058	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:96944058G>A	uc002svu.2	-	39	5613	c.5527C>T	c.(5527-5529)CGA>TGA	p.R1843*	SNRNP200_uc002svt.2_Nonsense_Mutation_p.R453*|SNRNP200_uc010yuj.1_RNA	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1843	SEC63 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10																		---	---	---	---
FER1L5	90342	broad.mit.edu	37	2	97365388	97365388	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97365388T>C	uc010fia.2	+	42	4793	c.4793T>C	c.(4792-4794)GTC>GCC	p.V1598A	FER1L5_uc002sws.3_Missense_Mutation_p.V316A|FER1L5_uc002swt.3_Missense_Mutation_p.V316A|FER1L5_uc010yus.1_Missense_Mutation_p.V315A	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1598	C2 5.					integral to membrane				ovary(1)	1																		---	---	---	---
ANKRD23	200539	broad.mit.edu	37	2	97505471	97505471	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97505471C>T	uc002sxa.2	-	8	844	c.815G>A	c.(814-816)CGG>CAG	p.R272Q	ANKRD23_uc002sxb.2_RNA|ANKRD23_uc002sxc.2_Missense_Mutation_p.R230Q	NM_144994	NP_659431	Q86SG2	ANR23_HUMAN	diabetes related ankyrin repeat protein	272						nucleus				ovary(1)	1																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109371681	109371681	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109371681T>G	uc002tem.3	+	17	2558	c.2432T>G	c.(2431-2433)CTG>CGG	p.L811R		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	811					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109382947	109382947	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109382947T>C	uc002tem.3	+	20	6078	c.5952T>C	c.(5950-5952)GGT>GGC	p.G1984G		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1984					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
SCTR	6344	broad.mit.edu	37	2	120231031	120231031	+	Missense_Mutation	SNP	G	A	A	rs144705246	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:120231031G>A	uc002tma.2	-	4	629	c.403C>T	c.(403-405)CGG>TGG	p.R135W	SCTR_uc002tlz.2_5'UTR	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	135	Extracellular (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)													---	---	---	---
SCTR	6344	broad.mit.edu	37	2	120236486	120236486	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:120236486C>A	uc002tma.2	-	3	428	c.202G>T	c.(202-204)GGG>TGG	p.G68W	SCTR_uc002tlz.2_5'UTR	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	68	Extracellular (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)													---	---	---	---
TMEM177	80775	broad.mit.edu	37	2	120439310	120439310	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:120439310G>A	uc010flg.1	+	2	1354	c.881G>A	c.(880-882)CGC>CAC	p.R294H	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Missense_Mutation_p.R294H|TMEM177_uc002tmd.2_Missense_Mutation_p.R294H|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	294						integral to membrane				ovary(1)	1	Colorectal(110;0.196)																	---	---	---	---
MBD5	55777	broad.mit.edu	37	2	149226158	149226158	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:149226158G>T	uc002twm.3	+	9	1634	c.646G>T	c.(646-648)GGC>TGC	p.G216C	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.G216C|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	216						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)														---	---	---	---
MBD5	55777	broad.mit.edu	37	2	149240765	149240765	+	Missense_Mutation	SNP	G	A	A	rs116207524	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:149240765G>A	uc002twm.3	+	10	3593	c.2605G>A	c.(2605-2607)GTC>ATC	p.V869I	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.V869I|MBD5_uc002two.2_5'Flank|MBD5_uc002twp.2_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	869						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152544188	152544188	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152544188G>A	uc010fnx.2	-	26	2666	c.2475C>T	c.(2473-2475)GAC>GAT	p.D825D		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	825	Nebulin 19.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
GALNT13	114805	broad.mit.edu	37	2	155102337	155102337	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:155102337C>T	uc002tyr.3	+	7	1266	c.699C>T	c.(697-699)GTC>GTT	p.V233V	GALNT13_uc002tyt.3_Silent_p.V233V|GALNT13_uc010foc.1_Silent_p.V52V|GALNT13_uc010fod.2_5'UTR	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	233	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
ACVR1C	130399	broad.mit.edu	37	2	158390497	158390497	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158390497C>T	uc002tzk.3	-	9	1658	c.1415G>A	c.(1414-1416)CGC>CAC	p.R472H	ACVR1C_uc002tzl.3_Missense_Mutation_p.R392H|ACVR1C_uc010fof.2_Missense_Mutation_p.R315H|ACVR1C_uc010foe.2_Missense_Mutation_p.R422H	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	472	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7																		---	---	---	---
BAZ2B	29994	broad.mit.edu	37	2	160295638	160295638	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160295638C>T	uc002uao.2	-	7	1134	c.782G>A	c.(781-783)AGT>AAT	p.S261N	BAZ2B_uc002uap.2_Missense_Mutation_p.S259N|BAZ2B_uc002uas.1_Missense_Mutation_p.S198N|BAZ2B_uc002uau.1_Missense_Mutation_p.S259N|BAZ2B_uc002uaq.1_Missense_Mutation_p.S189N|BAZ2B_uc002uat.3_Missense_Mutation_p.S198N|BAZ2B_uc010fop.1_Missense_Mutation_p.S259N	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	261	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4																		---	---	---	---
LY75	4065	broad.mit.edu	37	2	160755441	160755441	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160755441A>G	uc002ubc.3	-	2	293	c.224T>C	c.(223-225)CTC>CCC	p.L75P	LY75_uc002ubb.3_Missense_Mutation_p.L75P|LY75_uc010fos.2_Missense_Mutation_p.L75P|LY75_uc010fot.1_Missense_Mutation_p.L75P	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	75	Extracellular (Potential).|Ricin B-type lectin.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)														---	---	---	---
GCA	25801	broad.mit.edu	37	2	163215634	163215634	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163215634G>T	uc002ucg.2	+	6	711	c.535G>T	c.(535-537)GTT>TTT	p.V179F	GCA_uc010zcu.1_Missense_Mutation_p.V160F	NM_012198	NP_036330	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	179	EF-hand 4.				cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity				0																		---	---	---	---
COBLL1	22837	broad.mit.edu	37	2	165551064	165551064	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:165551064G>T	uc010zcw.1	-	15	3277	c.3153C>A	c.(3151-3153)GCC>GCA	p.A1051A	COBLL1_uc002ucp.2_Silent_p.A984A|COBLL1_uc002ucq.2_Silent_p.A946A|COBLL1_uc010zcx.1_Silent_p.A992A|COBLL1_uc002ucn.2_Silent_p.A412A|COBLL1_uc002uco.2_Silent_p.A715A	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	1022										ovary(2)|pancreas(1)	3																		---	---	---	---
SCN3A	6328	broad.mit.edu	37	2	165986605	165986605	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:165986605G>A	uc002ucx.2	-	17	3259	c.2767C>T	c.(2767-2769)CGG>TGG	p.R923W	SCN3A_uc002ucy.2_Missense_Mutation_p.R874W|SCN3A_uc002ucz.2_Missense_Mutation_p.R874W|SCN3A_uc002uda.1_Missense_Mutation_p.R743W|SCN3A_uc002udb.1_Missense_Mutation_p.R743W	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	923						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)													---	---	---	---
XIRP2	129446	broad.mit.edu	37	2	168106895	168106895	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168106895A>G	uc002udx.2	+	8	9011	c.8993A>G	c.(8992-8994)CAC>CGC	p.H2998R	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.H2823R|XIRP2_uc010fpq.2_Missense_Mutation_p.H2776R|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.H344R	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2823	Potential.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---
LRP2	4036	broad.mit.edu	37	2	170101368	170101368	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170101368G>A	uc002ues.2	-	22	3478	c.3265C>T	c.(3265-3267)CGC>TGC	p.R1089C	LRP2_uc010zdf.1_Missense_Mutation_p.R952C	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1089	LDL-receptor class A 9.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)													---	---	---	---
DYNC1I2	1781	broad.mit.edu	37	2	172583353	172583353	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172583353A>C	uc002uha.1	+	11	1088	c.923A>C	c.(922-924)GAG>GCG	p.E308A	DYNC1I2_uc002uhc.2_Missense_Mutation_p.E282A|DYNC1I2_uc002uhb.1_Missense_Mutation_p.E282A|DYNC1I2_uc010zds.1_Missense_Mutation_p.E300A|DYNC1I2_uc002uhd.1_Missense_Mutation_p.E302A|DYNC1I2_uc002uhe.1_Missense_Mutation_p.E308A|DYNC1I2_uc002uhf.1_Missense_Mutation_p.E282A|DYNC1I2_uc010zdt.1_Missense_Mutation_p.E300A|DYNC1I2_uc002uhg.1_Missense_Mutation_p.E223A|DYNC1I2_uc010zdu.1_Missense_Mutation_p.E31A	NM_001378	NP_001369	Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	308	WD 1.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.198)															---	---	---	---
CHN1	1123	broad.mit.edu	37	2	175664964	175664964	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:175664964G>A	uc002uji.2	-	13	1790	c.1260C>T	c.(1258-1260)ATC>ATT	p.I420I	CHN1_uc010zeq.1_Silent_p.I394I|CHN1_uc002ujj.2_Silent_p.I195I|CHN1_uc002ujg.2_Silent_p.I295I	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	420	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)					T	TAF15	extraskeletal myxoid chondrosarcoma								---	---	---	---
TTN	7273	broad.mit.edu	37	2	179428524	179428524	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179428524C>T	uc010zfg.1	-	275	74855	c.74631G>A	c.(74629-74631)ATG>ATA	p.M24877I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.M18572I|TTN_uc010zfi.1_Missense_Mutation_p.M18505I|TTN_uc010zfj.1_Missense_Mutation_p.M18380I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25804							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179434204	179434204	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179434204C>T	uc010zfg.1	-	275	69175	c.68951G>A	c.(68950-68952)CGA>CAA	p.R22984Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16679Q|TTN_uc010zfi.1_Missense_Mutation_p.R16612Q|TTN_uc010zfj.1_Missense_Mutation_p.R16487Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23911							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179460530	179460530	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179460530G>A	uc010zfg.1	-	244	50071	c.49847C>T	c.(49846-49848)CCA>CTA	p.P16616L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P10311L|TTN_uc010zfi.1_Missense_Mutation_p.P10244L|TTN_uc010zfj.1_Missense_Mutation_p.P10119L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17543							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179472135	179472135	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179472135T>G	uc010zfg.1	-	226	45800	c.45576A>C	c.(45574-45576)GAA>GAC	p.E15192D	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E8887D|TTN_uc010zfi.1_Missense_Mutation_p.E8820D|TTN_uc010zfj.1_Missense_Mutation_p.E8695D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16119							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179552924	179552924	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179552924G>A	uc010zfg.1	-	124	28717	c.28493C>T	c.(28492-28494)TCA>TTA	p.S9498L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S6159L|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10425							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179605532	179605532	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179605532A>G	uc010zfh.1	-	46	12139	c.11915T>C	c.(11914-11916)CTC>CCC	p.L3972P	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.L3905P|TTN_uc010zfj.1_Missense_Mutation_p.L3780P|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
SESTD1	91404	broad.mit.edu	37	2	179986571	179986571	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179986571A>T	uc002uni.3	-	13	1518	c.1368T>A	c.(1366-1368)GAT>GAA	p.D456E	SESTD1_uc002unh.3_5'UTR	NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	456	Spectrin 2.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)															---	---	---	---
SSFA2	6744	broad.mit.edu	37	2	182786912	182786912	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182786912C>T	uc002uoi.2	+	16	3770	c.3448C>T	c.(3448-3450)CGA>TGA	p.R1150*	SSFA2_uc002uoh.2_Nonsense_Mutation_p.R1150*|SSFA2_uc002uoj.2_Nonsense_Mutation_p.R1128*|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Nonsense_Mutation_p.R975*|SSFA2_uc002uol.2_Nonsense_Mutation_p.R997*|SSFA2_uc002uom.2_Nonsense_Mutation_p.R614*	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	1150						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)															---	---	---	---
PPP1R1C	151242	broad.mit.edu	37	2	182852584	182852584	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182852584A>G	uc002uoo.2	+	2	387	c.100A>G	c.(100-102)ACA>GCA	p.T34A	PPP1R1C_uc002uon.2_Intron|PPP1R1C_uc002uop.1_Missense_Mutation_p.T34A|PPP1R1C_uc010frm.1_Missense_Mutation_p.T41A|PPP1R1C_uc010frn.1_RNA	NM_001080545	NP_001074014	Q8WVI7	PPR1C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	34					signal transduction	cytoplasm	protein phosphatase inhibitor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0628)															---	---	---	---
PDE1A	5136	broad.mit.edu	37	2	183066525	183066525	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183066525T>C	uc002uos.2	-						PDE1A_uc010zfp.1_Intron|PDE1A_uc002uoq.1_Intron|PDE1A_uc010zfq.1_Intron|PDE1A_uc002uor.2_Intron|PDE1A_uc002uou.2_Intron	NM_001003683	NP_001003683			phosphodiesterase 1A isoform 2						activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)															---	---	---	---
NCKAP1	10787	broad.mit.edu	37	2	183822241	183822241	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183822241A>G	uc002upc.2	-	19	2367	c.1965T>C	c.(1963-1965)CCT>CCC	p.P655P	NCKAP1_uc002upb.2_Silent_p.P661P	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	655					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)															---	---	---	---
ANKRD44	91526	broad.mit.edu	37	2	197878289	197878289	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197878289C>T	uc002uua.1	-	18	1872	c.1795G>A	c.(1795-1797)GCA>ACA	p.A599T	ANKRD44_uc002utz.3_Missense_Mutation_p.A331T	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	624	ANK 18.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)															---	---	---	---
CLK1	1195	broad.mit.edu	37	2	201724396	201724396	+	Intron	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201724396A>C	uc002uwe.2	-						CLK1_uc002uwd.2_5'Flank|CLK1_uc010zhi.1_Intron|CLK1_uc002uwf.2_Intron|CLK1_uc002uwg.2_Intron|CLK1_uc010fsv.2_Intron	NM_004071	NP_004062			CDC-like kinase 1 isoform 1						cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2																		---	---	---	---
TRAK2	66008	broad.mit.edu	37	2	202272204	202272204	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202272204T>C	uc002uyb.3	-	3	654	c.208A>G	c.(208-210)ACT>GCT	p.T70A	TRAK2_uc002uyc.2_Missense_Mutation_p.T70A	NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	70						early endosome|plasma membrane	GABA receptor binding				0																		---	---	---	---
BMPR2	659	broad.mit.edu	37	2	203384875	203384875	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:203384875T>G	uc002uzf.3	+	7	2066	c.918T>G	c.(916-918)CAT>CAG	p.H306Q	BMPR2_uc010ftr.2_Missense_Mutation_p.H306Q	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	306	Protein kinase.|Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9																		---	---	---	---
NBEAL1	65065	broad.mit.edu	37	2	204045236	204045236	+	Splice_Site	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204045236G>A	uc002uzt.3	+	42	6841	c.6508_splice	c.e42+1	p.Q2170_splice	NBEAL1_uc002uzs.3_Splice_Site_p.Q880_splice	NM_001114132	NP_001107604			neurobeachin-like 1 isoform 3								binding			ovary(1)|skin(1)	2																		---	---	---	---
NBEAL1	65065	broad.mit.edu	37	2	204075771	204075771	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204075771G>A	uc002uzt.3	+	53	8122	c.7789G>A	c.(7789-7791)GGA>AGA	p.G2597R	NBEAL1_uc002uzs.3_Missense_Mutation_p.G1238R|NBEAL1_uc002uzu.2_Missense_Mutation_p.G92R	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2597							binding			ovary(1)|skin(1)	2																		---	---	---	---
PIKFYVE	200576	broad.mit.edu	37	2	209198225	209198225	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:209198225A>G	uc002vcz.2	+						PIKFYVE_uc002vcy.1_Intron	NM_015040	NP_055855			phosphatidylinositol-3-phosphate 5-kinase type						cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10																		---	---	---	---
ABCA12	26154	broad.mit.edu	37	2	215823039	215823039	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:215823039C>T	uc002vew.2	-	41	6299	c.6079G>A	c.(6079-6081)GTG>ATG	p.V2027M	ABCA12_uc002vev.2_Missense_Mutation_p.V1709M|ABCA12_uc010zjn.1_Missense_Mutation_p.V954M	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2027					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)														---	---	---	---
FN1	2335	broad.mit.edu	37	2	216226782	216226782	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216226782G>A	uc002vfa.2	-	45	7538	c.7272C>T	c.(7270-7272)TGC>TGT	p.C2424C	FN1_uc002vfb.2_Silent_p.C2212C|FN1_uc002vfc.2_Silent_p.C2187C|FN1_uc002vfd.2_Silent_p.C2368C|FN1_uc002vfe.2_Silent_p.C2302C|FN1_uc002vff.2_Silent_p.C2277C|FN1_uc002vfg.2_Silent_p.C2243C|FN1_uc002vfh.2_Silent_p.C2123C|FN1_uc002vfi.2_Silent_p.C2393C|FN1_uc002vfj.2_Silent_p.C2214C|FN1_uc002vez.2_Silent_p.C587C|FN1_uc010zjp.1_Silent_p.C961C	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	2333	Fibrin-binding 2.|Fibronectin type-I 12.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
FN1	2335	broad.mit.edu	37	2	216229623	216229623	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216229623G>A	uc002vfa.2	-	44	7496	c.7230C>T	c.(7228-7230)TGC>TGT	p.C2410C	FN1_uc002vfb.2_Silent_p.C2198C|FN1_uc002vfc.2_Silent_p.C2173C|FN1_uc002vfd.2_Silent_p.C2354C|FN1_uc002vfe.2_Silent_p.C2288C|FN1_uc002vff.2_Silent_p.C2263C|FN1_uc002vfg.2_Silent_p.C2229C|FN1_uc002vfh.2_Silent_p.C2109C|FN1_uc002vfi.2_Silent_p.C2379C|FN1_uc002vfj.2_Silent_p.C2200C|FN1_uc002vez.2_Silent_p.C573C|FN1_uc010zjp.1_Silent_p.C947C|FN1_uc002vfk.1_RNA|FN1_uc010fva.1_RNA|FN1_uc010fvb.1_RNA	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	2319	Fibrin-binding 2.|Fibronectin type-I 12.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
FN1	2335	broad.mit.edu	37	2	216248175	216248175	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216248175G>A	uc002vfa.2	-	31	5192	c.4926C>T	c.(4924-4926)ACC>ACT	p.T1642T	FN1_uc002vfb.2_Silent_p.T1551T|FN1_uc002vfc.2_Silent_p.T1551T|FN1_uc002vfd.2_Silent_p.T1642T|FN1_uc002vfe.2_Silent_p.T1551T|FN1_uc002vff.2_Silent_p.T1551T|FN1_uc002vfg.2_Silent_p.T1551T|FN1_uc002vfh.2_Silent_p.T1551T|FN1_uc002vfi.2_Silent_p.T1642T|FN1_uc002vfj.2_Silent_p.T1642T|FN1_uc002vez.2_5'UTR|FN1_uc010zjp.1_Silent_p.T269T|FN1_uc010fvc.1_Silent_p.T4T|FN1_uc010fvd.1_Silent_p.T4T	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1641	Fibronectin type-III 12; extra domain.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
FN1	2335	broad.mit.edu	37	2	216262429	216262429	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216262429G>A	uc002vfa.2	-	22	3757	c.3491C>T	c.(3490-3492)GCG>GTG	p.A1164V	FN1_uc002vfb.2_Missense_Mutation_p.A1164V|FN1_uc002vfc.2_Missense_Mutation_p.A1164V|FN1_uc002vfd.2_Missense_Mutation_p.A1164V|FN1_uc002vfe.2_Missense_Mutation_p.A1164V|FN1_uc002vff.2_Missense_Mutation_p.A1164V|FN1_uc002vfg.2_Missense_Mutation_p.A1164V|FN1_uc002vfh.2_Missense_Mutation_p.A1164V|FN1_uc002vfi.2_Missense_Mutation_p.A1164V|FN1_uc002vfj.2_Missense_Mutation_p.A1164V	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1164	|Fibronectin type-III 6.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
SMARCAL1	50485	broad.mit.edu	37	2	217285159	217285159	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:217285159C>T	uc002vgc.3	+	5	1330	c.1000C>T	c.(1000-1002)CGA>TGA	p.R334*	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Nonsense_Mutation_p.R334*|SMARCAL1_uc010fvg.2_Nonsense_Mutation_p.R334*	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	334					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)										Schimke_Immuno-Osseous_Dysplasia				---	---	---	---
TNS1	7145	broad.mit.edu	37	2	218713378	218713378	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:218713378C>T	uc002vgt.2	-	17	1885	c.1487G>A	c.(1486-1488)CGG>CAG	p.R496Q	TNS1_uc002vgr.2_Missense_Mutation_p.R496Q|TNS1_uc002vgs.2_Missense_Mutation_p.R496Q|TNS1_uc010zjv.1_Missense_Mutation_p.R496Q|TNS1_uc010fvj.1_Missense_Mutation_p.R564Q|TNS1_uc010fvk.1_Missense_Mutation_p.R621Q|TNS1_uc010fvi.1_Missense_Mutation_p.R183Q	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	496						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)														---	---	---	---
CYP27A1	1593	broad.mit.edu	37	2	219677156	219677156	+	Intron	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219677156G>T	uc002viz.3	+							NM_000784	NP_000775			cytochrome P450, family 27, subfamily A,						bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)													---	---	---	---
PAX3	5077	broad.mit.edu	37	2	223159014	223159014	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223159014G>T	uc010fwo.2	-	4	824	c.458C>A	c.(457-459)TCC>TAC	p.S153Y	PAX3_uc002vmt.1_Missense_Mutation_p.S153Y|PAX3_uc002vmy.1_Missense_Mutation_p.S152Y|PAX3_uc002vmv.1_Missense_Mutation_p.S153Y|PAX3_uc002vmw.1_Missense_Mutation_p.S153Y|PAX3_uc002vmx.1_Missense_Mutation_p.S153Y|PAX3_uc002vmz.1_Missense_Mutation_p.S153Y|PAX3_uc002vna.1_Missense_Mutation_p.S153Y	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	153	Paired.				apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)				T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						---	---	---	---
FARSB	10056	broad.mit.edu	37	2	223505594	223505594	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223505594A>C	uc002vne.1	-	4	361	c.326T>G	c.(325-327)ATT>AGT	p.I109S	FARSB_uc010zlq.1_Missense_Mutation_p.I129S|FARSB_uc002vnf.1_Missense_Mutation_p.I10S	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	109					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)													---	---	---	---
SCG2	7857	broad.mit.edu	37	2	224463172	224463172	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:224463172G>C	uc002vnm.2	-	2	962	c.829C>G	c.(829-831)CAA>GAA	p.Q277E		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	277					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)														---	---	---	---
FAM124B	79843	broad.mit.edu	37	2	225265913	225265913	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:225265913C>T	uc002vnx.2	-	1	799	c.573G>A	c.(571-573)CTG>CTA	p.L191L	FAM124B_uc002vnw.2_Silent_p.L191L	NM_001122779	NP_001116251	Q9H5Z6	F124B_HUMAN	hypothetical protein LOC79843 isoform a	191							protein binding			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)														---	---	---	---
COL4A3	1285	broad.mit.edu	37	2	228153918	228153918	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228153918A>G	uc002vom.1	+	35	3096	c.2934A>G	c.(2932-2934)CCA>CCG	p.P978P	COL4A3_uc002von.1_Silent_p.P978P|COL4A3_uc002voo.1_Silent_p.P978P|COL4A3_uc002vop.1_Silent_p.P978P|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	978	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)														---	---	---	---
MFF	56947	broad.mit.edu	37	2	228211948	228211948	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228211948A>G	uc002vos.2	+	8	1018	c.600A>G	c.(598-600)ACA>ACG	p.T200T	MFF_uc002vot.2_Silent_p.T149T|MFF_uc002vou.2_Intron|MFF_uc002vov.2_Intron|MFF_uc002vow.2_Intron|MFF_uc002vox.2_Intron|MFF_uc002voy.2_Silent_p.T200T|MFF_uc002voz.2_Intron|MFF_uc002vpa.2_5'UTR	NM_020194	NP_064579	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	200	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane				large_intestine(1)	1																		---	---	---	---
TM4SF20	79853	broad.mit.edu	37	2	228228629	228228629	+	Silent	SNP	C	T	T	rs141014397		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228228629C>T	uc002vpb.2	-	4	539	c.501G>A	c.(499-501)GCG>GCA	p.A167A		NM_024795	NP_079071	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	167	Extracellular (Potential).					integral to membrane|plasma membrane					0		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)														---	---	---	---
SPHKAP	80309	broad.mit.edu	37	2	228881110	228881110	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228881110C>T	uc002vpq.2	-						SPHKAP_uc002vpp.2_Intron|SPHKAP_uc010zlx.1_Intron	NM_001142644	NP_001136116			sphingosine kinase type 1-interacting protein							cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)														---	---	---	---
PID1	55022	broad.mit.edu	37	2	229890462	229890462	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:229890462G>A	uc002vpr.3	-	3	677	c.639C>T	c.(637-639)CAC>CAT	p.H213H	PID1_uc002vps.3_Silent_p.H211H|PID1_uc002vpt.3_Silent_p.H180H|PID1_uc002vpu.3_Silent_p.H131H	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	213	PID.					cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)														---	---	---	---
PID1	55022	broad.mit.edu	37	2	230020592	230020592	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230020592G>A	uc002vpr.3	-	2	256	c.218C>T	c.(217-219)GCC>GTC	p.A73V	PID1_uc002vps.3_Missense_Mutation_p.A71V|PID1_uc002vpt.3_Missense_Mutation_p.A40V|PID1_uc002vpu.3_Intron	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	73						cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)														---	---	---	---
SP100	6672	broad.mit.edu	37	2	231313824	231313824	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231313824G>A	uc002vqt.2	+	6	686	c.545G>A	c.(544-546)CGA>CAA	p.R182Q	SP100_uc002vqs.2_Missense_Mutation_p.R182Q|SP100_uc002vqu.1_Missense_Mutation_p.R182Q|SP100_uc010zmb.1_Missense_Mutation_p.R182Q|SP100_uc002vqq.1_Missense_Mutation_p.R182Q|SP100_uc002vqr.1_Missense_Mutation_p.R157Q|SP100_uc010zmc.1_Missense_Mutation_p.R157Q|SP100_uc002vqv.1_Missense_Mutation_p.R146Q	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	182					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)														---	---	---	---
B3GNT7	93010	broad.mit.edu	37	2	232263030	232263030	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:232263030C>T	uc002vrs.2	+	2	780	c.600C>T	c.(598-600)TAC>TAT	p.Y200Y		NM_145236	NP_660279	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal	200	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)														---	---	---	---
GBX2	2637	broad.mit.edu	37	2	237074908	237074908	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:237074908C>T	uc002vvw.1	-	2	734	c.696G>A	c.(694-696)CCG>CCA	p.P232P	GBX2_uc010zng.1_3'UTR	NM_001485	NP_001476	P52951	GBX2_HUMAN	gastrulation brain homeo box 2	232				QAAHKEEDPGHALEETPPSSGA -> PGSSQGGRPGPRGGG DPAEQRR (in Ref. 6).		nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)														---	---	---	---
COL6A3	1293	broad.mit.edu	37	2	238253469	238253469	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238253469C>T	uc002vwl.2	-	36	7477	c.7192G>A	c.(7192-7194)GTC>ATC	p.V2398I	COL6A3_uc002vwo.2_Missense_Mutation_p.V2192I|COL6A3_uc010znj.1_Missense_Mutation_p.V1791I|COL6A3_uc002vwj.2_5'Flank|COL6A3_uc002vwp.1_Missense_Mutation_p.V219I	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2398	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)														---	---	---	---
COL6A3	1293	broad.mit.edu	37	2	238277420	238277420	+	Silent	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238277420C>A	uc002vwl.2	-	10	4971	c.4686G>T	c.(4684-4686)GTG>GTT	p.V1562V	COL6A3_uc002vwo.2_Silent_p.V1356V|COL6A3_uc010znj.1_Silent_p.V955V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1562	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)														---	---	---	---
PER2	8864	broad.mit.edu	37	2	239167156	239167156	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239167156C>A	uc002vyc.2	-	15	1994	c.1757G>T	c.(1756-1758)TGC>TTC	p.C586F	PER2_uc010znv.1_Missense_Mutation_p.C586F	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	586	CSNK1E binding domain (By similarity).				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)														---	---	---	---
HDLBP	3069	broad.mit.edu	37	2	242194469	242194469	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242194469T>C	uc002waz.2	-	9	1413	c.1185A>G	c.(1183-1185)CCA>CCG	p.P395P	HDLBP_uc002wba.2_Silent_p.P395P|HDLBP_uc002wbb.2_Silent_p.P347P|HDLBP_uc010fzn.1_Silent_p.P124P	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	395	KH 4.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)														---	---	---	---
NEU4	129807	broad.mit.edu	37	2	242757365	242757365	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242757365T>C	uc010fzr.2	+						NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Intron|NEU4_uc002wcn.1_Intron|NEU4_uc002wco.1_Intron|NEU4_uc002wcp.1_Intron	NM_080741	NP_542779			sialidase 4							lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)														---	---	---	---
CHL1	10752	broad.mit.edu	37	3	439979	439979	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:439979C>T	uc003bou.2	+	24	3387	c.3116C>T	c.(3115-3117)CCG>CTG	p.P1039L	CHL1_uc003bot.2_Missense_Mutation_p.P1055L|CHL1_uc003bow.1_Missense_Mutation_p.P1039L|CHL1_uc011asi.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1039	Extracellular (Potential).	Cleavage; by ADAM8 (By similarity).			axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)														---	---	---	---
ARPC4	10093	broad.mit.edu	37	3	9839372	9839372	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9839372C>T	uc003bsz.1	+	2	612	c.33C>T	c.(31-33)GCC>GCT	p.A11A	ARPC4_uc003bta.1_5'UTR|ARPC4_uc003btb.1_5'UTR|ARPC4_uc003btc.1_5'UTR|TTLL3_uc003btd.3_5'UTR	NM_005718	NP_005709	P59998	ARPC4_HUMAN	actin related protein 2/3 complex subunit 4	11					actin filament polymerization|actin nucleation	Arp2/3 protein complex|cell projection|cytoplasm	actin binding				0	Medulloblastoma(99;0.227)																	---	---	---	---
PPARG	5468	broad.mit.edu	37	3	12421297	12421297	+	Silent	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12421297C>A	uc003bwx.2	+	2	268	c.177C>A	c.(175-177)TCC>TCA	p.S59S	PPARG_uc003bwr.2_Silent_p.S31S|PPARG_uc003bws.2_Silent_p.S31S|PPARG_uc003bwu.2_Silent_p.S31S|PPARG_uc003bwv.2_Silent_p.S31S|PPARG_uc010hea.1_RNA|PPARG_uc003bwq.1_Silent_p.S31S|PPARG_uc010hdz.1_RNA|PPARG_uc003bwt.1_Silent_p.S31S|PPARG_uc003bww.1_Silent_p.S59S	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	59					activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)			T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						---	---	---	---
RAF1	5894	broad.mit.edu	37	3	12660008	12660008	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12660008A>G	uc003bxf.3	-						RAF1_uc011auu.1_Intron	NM_002880	NP_002871			v-raf-1 murine leukemia viral oncogene homolog						activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)			T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				---	---	---	---
CAND2	23066	broad.mit.edu	37	3	12856772	12856772	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12856772T>C	uc003bxk.2	+	8	1188	c.1139T>C	c.(1138-1140)GTG>GCG	p.V380A	CAND2_uc003bxj.2_Missense_Mutation_p.V287A	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	380	HEAT 9.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4																		---	---	---	---
KCNH8	131096	broad.mit.edu	37	3	19575324	19575324	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:19575324G>A	uc003cbk.1	+	16	3252	c.3057G>A	c.(3055-3057)ACG>ACA	p.T1019T	KCNH8_uc010hex.1_Silent_p.T480T	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	1019	Ser-rich.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5																		---	---	---	---
TOP2B	7155	broad.mit.edu	37	3	25642584	25642584	+	Intron	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:25642584T>G	uc003cdj.2	-						TOP2B_uc011awm.1_Intron|TOP2B_uc010hff.1_Intron	NM_001068	NP_001059			DNA topoisomerase II, beta isozyme						DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5																		---	---	---	---
TOP2B	7155	broad.mit.edu	37	3	25650830	25650830	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:25650830T>C	uc003cdj.2	-	30	3922	c.3922A>G	c.(3922-3924)AGA>GGA	p.R1308G	TOP2B_uc011awm.1_Missense_Mutation_p.R165G|TOP2B_uc010hff.1_Missense_Mutation_p.R174G	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	1313					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5																		---	---	---	---
TOP2B	7155	broad.mit.edu	37	3	25668765	25668765	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:25668765T>A	uc011awn.1	-	16	1972	c.1929A>T	c.(1927-1929)AAA>AAT	p.K643N	TOP2B_uc003cdj.2_Missense_Mutation_p.K638N	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	643					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5																		---	---	---	---
RBMS3	27303	broad.mit.edu	37	3	29938929	29938929	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:29938929C>T	uc003cel.2	+	9	1081	c.851C>T	c.(850-852)ACG>ATG	p.T284M	RBMS3_uc003cek.2_Missense_Mutation_p.T284M|RBMS3_uc010hfq.2_Missense_Mutation_p.T297M|RBMS3_uc003cem.2_Missense_Mutation_p.T283M|RBMS3_uc010hfr.2_Missense_Mutation_p.T284M	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	284						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)																---	---	---	---
TRIM71	131405	broad.mit.edu	37	3	32932817	32932817	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32932817G>A	uc003cff.2	+	4	2184	c.2121G>A	c.(2119-2121)GCG>GCA	p.A707A		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	707	NHL 3.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3																		---	---	---	---
CLASP2	23122	broad.mit.edu	37	3	33543196	33543196	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33543196G>A	uc003cfu.2	-	37	4736	c.4382C>T	c.(4381-4383)GCG>GTG	p.A1461V	CLASP2_uc003cfs.2_Missense_Mutation_p.A668V|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1470										ovary(3)|central_nervous_system(1)	4																		---	---	---	---
CLASP2	23122	broad.mit.edu	37	3	33729800	33729800	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33729800C>T	uc003cfu.2	-	4	793	c.439G>A	c.(439-441)GTG>ATG	p.V147M	CLASP2_uc010hgb.2_RNA	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	147										ovary(3)|central_nervous_system(1)	4																		---	---	---	---
TRANK1	9881	broad.mit.edu	37	3	36874710	36874710	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:36874710C>T	uc003cgj.2	-	12	4884	c.4582G>A	c.(4582-4584)GTG>ATG	p.V1528M		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2078					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
TRANK1	9881	broad.mit.edu	37	3	36897192	36897192	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:36897192A>G	uc003cgj.2	-	3	2541	c.2239T>C	c.(2239-2241)TAC>CAC	p.Y747H		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1297					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
LRRFIP2	9209	broad.mit.edu	37	3	37162993	37162993	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37162993C>T	uc003cgp.2	-	7	743	c.320G>A	c.(319-321)GGC>GAC	p.G107D	LRRFIP2_uc011ayf.1_Missense_Mutation_p.G90D|LRRFIP2_uc003cgr.2_Intron|LRRFIP2_uc003cgs.3_Intron|LRRFIP2_uc003cgt.3_Intron	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	107	DVL3-binding.				Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1																		---	---	---	---
GOLGA4	2803	broad.mit.edu	37	3	37292888	37292888	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37292888G>A	uc003cgv.2	+	2	379	c.75G>A	c.(73-75)GCG>GCA	p.A25A	GOLGA4_uc010hgr.1_Silent_p.A25A|GOLGA4_uc003cgw.2_Silent_p.A25A|GOLGA4_uc010hgs.2_Silent_p.A25A|GOLGA4_uc003cgu.1_Silent_p.A25A	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	25					Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
VILL	50853	broad.mit.edu	37	3	38037234	38037234	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38037234A>G	uc003chj.2	+	5	632	c.346A>G	c.(346-348)AGG>GGG	p.R116G	VILL_uc003chk.1_Missense_Mutation_p.R116G|VILL_uc003chl.2_Missense_Mutation_p.R116G|VILL_uc010hgu.2_5'UTR	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	116					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)														---	---	---	---
SCN5A	6331	broad.mit.edu	37	3	38601896	38601896	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38601896G>A	uc003cio.2	-	23	4181	c.3987C>T	c.(3985-3987)GGC>GGT	p.G1329G	SCN5A_uc003cin.2_Silent_p.G1328G|SCN5A_uc003cil.3_Silent_p.G1329G|SCN5A_uc010hhi.2_Silent_p.G1329G|SCN5A_uc010hhk.2_Silent_p.G1328G|SCN5A_uc011ayr.1_Silent_p.G1275G|SCN5A_uc010hhj.1_Silent_p.G939G	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1329					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)													---	---	---	---
SCN5A	6331	broad.mit.edu	37	3	38608015	38608015	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38608015G>A	uc003cio.2	-	21	3919	c.3725C>T	c.(3724-3726)GCC>GTC	p.A1242V	SCN5A_uc003cin.2_Missense_Mutation_p.A1241V|SCN5A_uc003cil.3_Missense_Mutation_p.A1242V|SCN5A_uc010hhi.2_Missense_Mutation_p.A1242V|SCN5A_uc010hhk.2_Missense_Mutation_p.A1241V|SCN5A_uc011ayr.1_Missense_Mutation_p.A1188V|SCN5A_uc010hhj.1_Missense_Mutation_p.A852V	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1242	Helical; Name=S2 of repeat III; (Potential).				blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)													---	---	---	---
SCN5A	6331	broad.mit.edu	37	3	38620974	38620974	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38620974G>C	uc003cio.2	-	18	3435	c.3241C>G	c.(3241-3243)CCT>GCT	p.P1081A	SCN5A_uc003cin.2_Missense_Mutation_p.P1080A|SCN5A_uc003cil.3_Missense_Mutation_p.P1081A|SCN5A_uc010hhi.2_Missense_Mutation_p.P1081A|SCN5A_uc010hhk.2_Missense_Mutation_p.P1080A|SCN5A_uc011ayr.1_Intron|SCN5A_uc010hhj.1_Missense_Mutation_p.P691A	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1081					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)													---	---	---	---
SCN5A	6331	broad.mit.edu	37	3	38639229	38639229	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38639229G>A	uc003cio.2	-	14	2447	c.2253C>T	c.(2251-2253)GTC>GTT	p.V751V	SCN5A_uc003cin.2_Silent_p.V751V|SCN5A_uc003cil.3_Silent_p.V751V|SCN5A_uc010hhi.2_Silent_p.V751V|SCN5A_uc010hhk.2_Silent_p.V751V|SCN5A_uc011ayr.1_Silent_p.V751V|SCN5A_uc010hhj.1_Silent_p.V362V	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	751	Helical; Name=S2 of repeat II; (Potential).				blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)													---	---	---	---
SCN10A	6336	broad.mit.edu	37	3	38739639	38739639	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38739639T>C	uc003ciq.2	-	27	5072	c.5072A>G	c.(5071-5073)GAC>GGC	p.D1691G		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1691	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)													---	---	---	---
CX3CR1	1524	broad.mit.edu	37	3	39307753	39307753	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:39307753G>A	uc003cjl.2	-	2	340	c.248C>T	c.(247-249)ACT>ATT	p.T83I		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	83	Helical; Name=2; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)														---	---	---	---
MYRIP	25924	broad.mit.edu	37	3	40251387	40251387	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:40251387C>T	uc003cka.2	+	11	1843	c.1708C>T	c.(1708-1710)CGG>TGG	p.R570W	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Missense_Mutation_p.R570W|MYRIP_uc010hhw.2_Missense_Mutation_p.R481W|MYRIP_uc011ayz.1_Missense_Mutation_p.R383W|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	570	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)														---	---	---	---
HHATL	57467	broad.mit.edu	37	3	42740589	42740589	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:42740589C>T	uc003clw.2	-	5	370	c.223G>A	c.(223-225)GTC>ATC	p.V75I	HHATL_uc003clx.2_Missense_Mutation_p.V75I	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	75	Helical; (Potential).				negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)														---	---	---	---
ZNF167	55888	broad.mit.edu	37	3	44612251	44612251	+	Missense_Mutation	SNP	C	A	A	rs145479931	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44612251C>A	uc010hin.2	+	6	2037	c.1649C>A	c.(1648-1650)CCT>CAT	p.P550H	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.P550H|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	550					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)														---	---	---	---
FYCO1	79443	broad.mit.edu	37	3	46008705	46008705	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46008705G>A	uc003cpb.3	-	8	2327	c.2121C>T	c.(2119-2121)GGC>GGT	p.G707G	FYCO1_uc011bal.1_Silent_p.G707G	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	707	Potential.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)														---	---	---	---
LTF	4057	broad.mit.edu	37	3	46482949	46482949	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46482949C>T	uc003cpq.2	-	14	1719	c.1681G>A	c.(1681-1683)GTT>ATT	p.V561I	LTF_uc003fzr.2_Missense_Mutation_p.V517I|LTF_uc010hjh.2_Missense_Mutation_p.V559I|LTF_uc003cpr.2_Missense_Mutation_p.V548I	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	561	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)													---	---	---	---
SCAP	22937	broad.mit.edu	37	3	47462130	47462130	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47462130A>T	uc003crh.1	-	12	1732	c.1477T>A	c.(1477-1479)TCT>ACT	p.S493T	SCAP_uc011baz.1_Missense_Mutation_p.S238T|SCAP_uc003crg.2_Missense_Mutation_p.S101T	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	493	Cytoplasmic (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)												OREG0015548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SCAP	22937	broad.mit.edu	37	3	47467488	47467488	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47467488C>T	uc003crh.1	-	7	1164	c.909G>A	c.(907-909)ACG>ACA	p.T303T	SCAP_uc011baz.1_Silent_p.T48T|SCAP_uc003crg.2_Intron	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	303	Cytoplasmic (By similarity).|SSD.				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)														---	---	---	---
CSPG5	10675	broad.mit.edu	37	3	47619165	47619165	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47619165G>A	uc003crp.3	-	2	527	c.351C>T	c.(349-351)AGC>AGT	p.S117S	CSPG5_uc003crn.2_5'UTR|CSPG5_uc003cro.3_Silent_p.S117S|CSPG5_uc011bbb.1_5'UTR	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	117	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)														---	---	---	---
CELSR3	1951	broad.mit.edu	37	3	48698284	48698284	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48698284A>G	uc003cul.2	-	1	2065	c.1784T>C	c.(1783-1785)ATC>ACC	p.I595T	CELSR3_uc003cuf.1_Missense_Mutation_p.I665T	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	595	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)														---	---	---	---
CCDC71	64925	broad.mit.edu	37	3	49201445	49201445	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49201445C>T	uc003cwg.3	-	2	335	c.197G>A	c.(196-198)CGC>CAC	p.R66H		NM_022903	NP_075054	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	66										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)														---	---	---	---
KLHDC8B	200942	broad.mit.edu	37	3	49212181	49212181	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49212181G>A	uc003cwh.2	+	4	733	c.548G>A	c.(547-549)CGC>CAC	p.R183H	KLHDC8B_uc003cwi.1_Missense_Mutation_p.R56H	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	183	Kelch 5.					cytoplasm					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)														---	---	---	---
USP4	7375	broad.mit.edu	37	3	49332009	49332009	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49332009C>T	uc003cwq.2	-	14	1793	c.1714G>A	c.(1714-1716)GTG>ATG	p.V572M	USP4_uc003cwo.2_Missense_Mutation_p.V284M|USP4_uc003cwp.2_Missense_Mutation_p.V302M|USP4_uc003cwr.2_Missense_Mutation_p.V525M	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	572					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)														---	---	---	---
DAG1	1605	broad.mit.edu	37	3	49548116	49548116	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49548116T>C	uc003cxc.3	+	2	567	c.149T>C	c.(148-150)ATG>ACG	p.M50T		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	50	Required for laminin recognition.|O-glycosylated at one site.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)														---	---	---	---
APEH	327	broad.mit.edu	37	3	49713595	49713595	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49713595C>T	uc003cxf.2	+	6	949	c.549C>T	c.(547-549)GAC>GAT	p.D183D	APEH_uc010hkw.1_Silent_p.D183D	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	183					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)														---	---	---	---
MST1	4485	broad.mit.edu	37	3	49723549	49723549	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49723549G>A	uc003cxg.2	-	9	1165	c.1093C>T	c.(1093-1095)CGC>TGC	p.R365C	MST1_uc011bcs.1_Silent_p.C403C|MST1_uc010hkx.2_3'UTR|MST1_uc011bct.1_3'UTR	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	351	Kringle 3.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)														---	---	---	---
MST1R	4486	broad.mit.edu	37	3	49936356	49936356	+	Missense_Mutation	SNP	C	T	T	rs148258933		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49936356C>T	uc003cxy.3	-	3	1756	c.1492G>A	c.(1492-1494)GTG>ATG	p.V498M	MST1R_uc011bdd.1_Missense_Mutation_p.V498M|MST1R_uc011bde.1_Missense_Mutation_p.V498M|MST1R_uc011bdf.1_Intron|MST1R_uc011bdc.1_5'Flank	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	498	Extracellular (Potential).|Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)														---	---	---	---
RBM5	10181	broad.mit.edu	37	3	50155809	50155809	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50155809G>A	uc003cyg.2	+	25	2516	c.2368G>A	c.(2368-2370)GCA>ACA	p.A790T	RBM5_uc011bdk.1_Missense_Mutation_p.A618T|RBM5_uc003cyh.2_Missense_Mutation_p.A247T|uc003cyi.1_Intron	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	790	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
TMEM115	11070	broad.mit.edu	37	3	50396068	50396068	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50396068C>A	uc003dan.1	-	1	872	c.427G>T	c.(427-429)GGT>TGT	p.G143C		NM_007024	NP_008955	Q12893	TM115_HUMAN	PL6 protein	143	Helical; (Potential).				negative regulation of cell proliferation	Golgi apparatus|integral to membrane|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)														---	---	---	---
VPRBP	9730	broad.mit.edu	37	3	51458110	51458110	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51458110G>T	uc003dbe.1	-	14	2482	c.2314C>A	c.(2314-2316)CGG>AGG	p.R772R	VPRBP_uc003dbf.1_Silent_p.R48R	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	772					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)														---	---	---	---
STAB1	23166	broad.mit.edu	37	3	52551965	52551965	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52551965C>T	uc003dej.2	+	45	4781	c.4707C>T	c.(4705-4707)TGC>TGT	p.C1569C	STAB1_uc003dek.1_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1569	Extracellular (Potential).|EGF-like 13.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)														---	---	---	---
PDHB	5162	broad.mit.edu	37	3	58414314	58414314	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58414314T>C	uc003dkf.3	-	9	849	c.820A>G	c.(820-822)ATG>GTG	p.M274V	PDHB_uc003dke.3_Missense_Mutation_p.M232V|PDHB_uc003dkg.3_Missense_Mutation_p.M256V|PDHB_uc010hnl.2_Missense_Mutation_p.M256V|PDHB_uc011bff.1_Missense_Mutation_p.M256V	NM_000925	NP_000916	P11177	ODPB_HUMAN	pyruvate dehydrogenase (lipoamide) beta	274					glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(55;0.000179)|Kidney(10;0.00231)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.187)	NADH(DB00157)|Pyruvic acid(DB00119)													---	---	---	---
CADPS	8618	broad.mit.edu	37	3	62423862	62423862	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:62423862C>T	uc003dll.2	-	28	4054	c.3694G>A	c.(3694-3696)GCC>ACC	p.A1232T	CADPS_uc003dlj.1_Missense_Mutation_p.A187T|CADPS_uc003dlk.1_Missense_Mutation_p.A680T|CADPS_uc003dlm.2_Missense_Mutation_p.A1193T|CADPS_uc003dln.2_Missense_Mutation_p.A1153T	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1232	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)														---	---	---	---
PRICKLE2	166336	broad.mit.edu	37	3	64133159	64133159	+	Missense_Mutation	SNP	C	T	T	rs147289291	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64133159C>T	uc003dmf.2	-	7	1593	c.1007G>A	c.(1006-1008)CGC>CAC	p.R336H		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	336						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)														---	---	---	---
ADAMTS9	56999	broad.mit.edu	37	3	64592738	64592738	+	Silent	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64592738T>A	uc003dmg.2	-	23	3404	c.3372A>T	c.(3370-3372)GGA>GGT	p.G1124G	ADAMTS9_uc011bfo.1_Silent_p.G1096G|ADAMTS9_uc003dmh.1_Silent_p.G953G|ADAMTS9_uc011bfp.1_Silent_p.G35G	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1124	TSP type-1 6.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)														---	---	---	---
EPHA3	2042	broad.mit.edu	37	3	89259309	89259309	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:89259309T>C	uc003dqy.2	+	3	678	c.453T>C	c.(451-453)AGT>AGC	p.S151S	EPHA3_uc003dqx.1_Silent_p.S151S|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	151	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)											TSP Lung(6;0.00050)			---	---	---	---
GABRR3	200959	broad.mit.edu	37	3	97711889	97711889	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97711889A>T	uc011bgr.1	-	8	911	c.911T>A	c.(910-912)ATC>AAC	p.I304N		NM_001105580	NP_001099050	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 3	304	Helical; (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0																		---	---	---	---
IMPG2	50939	broad.mit.edu	37	3	100964765	100964765	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100964765G>T	uc003duq.1	-	12	1627	c.1424C>A	c.(1423-1425)TCC>TAC	p.S475Y	IMPG2_uc011bhe.1_Missense_Mutation_p.S338Y	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	475	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3																		---	---	---	---
FAM55C	91775	broad.mit.edu	37	3	101520160	101520160	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101520160C>T	uc003dvn.2	+	5	812	c.175C>T	c.(175-177)CGA>TGA	p.R59*	FAM55C_uc010hpn.2_Nonsense_Mutation_p.R59*	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	59						extracellular region				ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
FAM55C	91775	broad.mit.edu	37	3	101540650	101540650	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101540650G>A	uc003dvn.2	+	8	2169	c.1532G>A	c.(1531-1533)AGG>AAG	p.R511K	FAM55C_uc010hpn.2_Missense_Mutation_p.R511K	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	511						extracellular region				ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
TMPRSS7	344805	broad.mit.edu	37	3	111766741	111766741	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111766741G>A	uc010hqb.2	+	5	678	c.508G>A	c.(508-510)GCC>ACC	p.A170T	TMPRSS7_uc011bhr.1_Missense_Mutation_p.A25T	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	296	Extracellular (Potential).|CUB 1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2																		---	---	---	---
TMPRSS7	344805	broad.mit.edu	37	3	111769635	111769635	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111769635C>T	uc010hqb.2	+						TMPRSS7_uc011bhr.1_Intron	NM_001042575	NP_001036040			transmembrane protease, serine 7						proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2																		---	---	---	---
BOC	91653	broad.mit.edu	37	3	112968754	112968754	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112968754C>T	uc003dzx.2	+						BOC_uc010hqi.2_Intron|BOC_uc003dzy.2_Intron|BOC_uc003dzz.2_Intron|BOC_uc003dzw.1_Intron|BOC_uc003eaa.1_Intron	NM_033254	NP_150279			brother of CDO precursor						cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)															---	---	---	---
KIAA2018	205717	broad.mit.edu	37	3	113375850	113375850	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113375850T>C	uc003eam.2	-	7	5090	c.4679A>G	c.(4678-4680)CAG>CGG	p.Q1560R	KIAA2018_uc003eal.2_Missense_Mutation_p.Q1504R	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1560	Gln-rich.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3																		---	---	---	---
ATP6V1A	523	broad.mit.edu	37	3	113497599	113497599	+	5'UTR	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113497599T>A	uc003eao.2	+	2					ATP6V1A_uc011bik.1_5'UTR	NM_001690	NP_001681			ATPase, H+ transporting, lysosomal V1 subunit A						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3																		---	---	---	---
KIAA1407	57577	broad.mit.edu	37	3	113753973	113753973	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113753973C>T	uc003eax.2	-	6	764	c.617G>A	c.(616-618)CGT>CAT	p.R206H	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.R184H|KIAA1407_uc011bip.1_Missense_Mutation_p.R193H	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	206	Potential.									ovary(2)	2																		---	---	---	---
ARHGAP31	57514	broad.mit.edu	37	3	119120974	119120974	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119120974G>A	uc003ecj.3	+	10	1907	c.1375G>A	c.(1375-1377)GAC>AAC	p.D459N		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	459					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2																		---	---	---	---
GTF2E1	2960	broad.mit.edu	37	3	120469477	120469477	+	Nonsense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:120469477T>G	uc003edz.3	+	2	192	c.78T>G	c.(76-78)TAT>TAG	p.Y26*	GTF2E1_uc003edy.2_Nonsense_Mutation_p.Y26*	NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	26	HTH TFE/IIEalpha-type.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)														---	---	---	---
POLQ	10721	broad.mit.edu	37	3	121179017	121179017	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121179017A>G	uc003eee.3	-	25	7161	c.7032T>C	c.(7030-7032)CAT>CAC	p.H2344H	POLQ_uc003eed.2_Silent_p.H1516H	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2344					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
POLQ	10721	broad.mit.edu	37	3	121206610	121206610	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121206610C>T	uc003eee.3	-	16	5297	c.5168G>A	c.(5167-5169)CGT>CAT	p.R1723H	POLQ_uc003eed.2_Missense_Mutation_p.R895H	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1723					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
GOLGB1	2804	broad.mit.edu	37	3	121411357	121411357	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121411357T>C	uc003eei.3	-	14	6965	c.6839A>G	c.(6838-6840)GAT>GGT	p.D2280G	GOLGB1_uc010hrc.2_Missense_Mutation_p.D2285G|GOLGB1_uc003eej.3_Missense_Mutation_p.D2246G	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2280	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)														---	---	---	---
HSPBAP1	79663	broad.mit.edu	37	3	122512524	122512524	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122512524C>T	uc003efu.1	-	1	127	c.4G>A	c.(4-6)GCA>ACA	p.A2T	DIRC2_uc003efw.3_5'Flank|DIRC2_uc010hrl.2_5'Flank|DIRC2_uc010hrm.2_5'Flank|HSPBAP1_uc003efv.1_Missense_Mutation_p.A2T	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	2						cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)														---	---	---	---
SEMA5B	54437	broad.mit.edu	37	3	122646807	122646807	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122646807G>A	uc003efz.1	-	8	984	c.680C>T	c.(679-681)GCC>GTC	p.A227V	SEMA5B_uc011bju.1_Missense_Mutation_p.A169V|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.A227V|SEMA5B_uc010hro.1_Missense_Mutation_p.A169V|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	227	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)														---	---	---	---
KALRN	8997	broad.mit.edu	37	3	124438126	124438126	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124438126C>T	uc003ehg.2	+	60	8897	c.8770C>T	c.(8770-8772)CGG>TGG	p.R2924W	KALRN_uc003ehk.2_Missense_Mutation_p.R1227W	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2923	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
ITGB5	3693	broad.mit.edu	37	3	124578267	124578267	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124578267G>T	uc003eho.2	-	3	480	c.183C>A	c.(181-183)ACC>ACA	p.T61T		NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	61	Extracellular (Potential).|PSI.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)														---	---	---	---
ZXDC	79364	broad.mit.edu	37	3	126185161	126185161	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126185161G>A	uc003eiv.2	-	5	1332	c.1278C>T	c.(1276-1278)TGC>TGT	p.C426C	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Silent_p.C426C	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	426	C2H2-type 9.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)														---	---	---	---
PLXNA1	5361	broad.mit.edu	37	3	126730890	126730890	+	Silent	SNP	G	A	A	rs144586368		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126730890G>A	uc003ejg.2	+	9	2137	c.2133G>A	c.(2131-2133)CAG>CAA	p.Q711Q		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	734	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)														---	---	---	---
KBTBD12	166348	broad.mit.edu	37	3	127642914	127642914	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:127642914C>T	uc010hsr.2	+	1	1013	c.1010C>T	c.(1009-1011)GCT>GTT	p.A337V	KBTBD12_uc003ejy.3_Intron|KBTBD12_uc010hsq.2_Intron|KBTBD12_uc003eka.3_Intron|KBTBD12_uc003ejz.2_Missense_Mutation_p.A337V	NM_207335	NP_997218	Q3ZCT8	KBTBC_HUMAN	kelch domain containing 6	337										ovary(1)	1																		---	---	---	---
EEFSEC	60678	broad.mit.edu	37	3	128127069	128127069	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128127069C>T	uc003eki.2	+	7	1796	c.1758C>T	c.(1756-1758)TTC>TTT	p.F586F	EEFSEC_uc003ekj.2_3'UTR	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	586						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1																		---	---	---	---
PLXND1	23129	broad.mit.edu	37	3	129290521	129290521	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129290521T>C	uc003emx.2	-	16	3344	c.3244A>G	c.(3244-3246)AGT>GGT	p.S1082G		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1082	Extracellular (Potential).|IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1																		---	---	---	---
ACAD11	84129	broad.mit.edu	37	3	132324009	132324009	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132324009C>A	uc003eov.3	-	12	1835	c.1455G>T	c.(1453-1455)GAG>GAT	p.E485D	ACAD11_uc011blr.1_Missense_Mutation_p.E96D	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	485						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1																		---	---	---	---
CLSTN2	64084	broad.mit.edu	37	3	140251228	140251228	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:140251228C>T	uc003etn.2	+	9	1597	c.1407C>T	c.(1405-1407)TAC>TAT	p.Y469Y	CLSTN2_uc003etm.2_Silent_p.Y469Y	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	469	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7															HNSCC(16;0.037)			---	---	---	---
CHST2	9435	broad.mit.edu	37	3	142840665	142840665	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142840665C>T	uc003evm.2	+	2	1896	c.1007C>T	c.(1006-1008)GCG>GTG	p.A336V		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	336	Lumenal (Potential).|PAPS (Probable).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3																		---	---	---	---
GYG1	2992	broad.mit.edu	37	3	148714687	148714687	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148714687T>C	uc003ewn.2	+	4	530	c.477T>C	c.(475-477)TTT>TTC	p.F159F	GYG1_uc011bnp.1_Intron|GYG1_uc003ewo.2_Silent_p.F159F|GYG1_uc003ewp.2_Silent_p.F159F	NM_004130	NP_004121	P46976	GLYG_HUMAN	glycogenin 1	159					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	glycogenin glucosyltransferase activity|metal ion binding|protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)															---	---	---	---
FAM194A	131831	broad.mit.edu	37	3	150387141	150387141	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150387141G>T	uc003eyg.2	-	12	1498	c.1441C>A	c.(1441-1443)CTA>ATA	p.L481I	FAM194A_uc003eyh.2_Missense_Mutation_p.L335I	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	481										skin(2)|ovary(1)	3																		---	---	---	---
SGEF	26084	broad.mit.edu	37	3	153839836	153839836	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:153839836C>T	uc011bog.1	+	2	266	c.55C>T	c.(55-57)CGG>TGG	p.R19W	uc003ezu.1_5'Flank|SGEF_uc011boh.1_Missense_Mutation_p.R19W	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	19					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
PLCH1	23007	broad.mit.edu	37	3	155282736	155282736	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155282736C>T	uc011bok.1	-	7	1278	c.1001G>A	c.(1000-1002)CGG>CAG	p.R334Q	PLCH1_uc011boj.1_Missense_Mutation_p.R334Q|PLCH1_uc011bol.1_Missense_Mutation_p.R316Q	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	334	PI-PLC X-box.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---
MFSD1	64747	broad.mit.edu	37	3	158537447	158537447	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:158537447C>T	uc003fcl.1	+	8	692	c.662C>T	c.(661-663)ACG>ATG	p.T221M	MFSD1_uc003fcm.1_RNA|MFSD1_uc003fcn.1_Missense_Mutation_p.T124M|MFSD1_uc011bow.1_Missense_Mutation_p.T182M|MFSD1_uc011box.1_Missense_Mutation_p.T148M	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	221	Helical; (Potential).				transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)															---	---	---	---
SI	6476	broad.mit.edu	37	3	164735854	164735854	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:164735854A>G	uc003fei.2	-	29	3486	c.3424T>C	c.(3424-3426)TAC>CAC	p.Y1142H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1142	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)										HNSCC(35;0.089)			---	---	---	---
SAMD7	344658	broad.mit.edu	37	3	169642898	169642898	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169642898A>G	uc003fgd.2	+	5	531	c.264A>G	c.(262-264)GAA>GAG	p.E88E	SAMD7_uc003fge.2_Silent_p.E88E|SAMD7_uc011bpo.1_5'UTR	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	88										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)															---	---	---	---
SLC7A14	57709	broad.mit.edu	37	3	170201230	170201230	+	Missense_Mutation	SNP	C	A	A	rs2276717	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170201230C>A	uc003fgz.2	-	6	1304	c.988G>T	c.(988-990)GGG>TGG	p.G330W	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	330						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)													OREG0015917	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TNIK	23043	broad.mit.edu	37	3	170857333	170857333	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170857333G>A	uc003fhh.2	-	14	1690	c.1345C>T	c.(1345-1347)CGA>TGA	p.R449*	TNIK_uc003fhi.2_Nonsense_Mutation_p.R449*|TNIK_uc003fhj.2_Intron|TNIK_uc003fhk.2_Nonsense_Mutation_p.R449*|TNIK_uc003fhl.2_Intron|TNIK_uc003fhm.2_Nonsense_Mutation_p.R449*|TNIK_uc003fhn.2_Intron|TNIK_uc003fho.2_Intron	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	449	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)															---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178916876	178916876	+	Missense_Mutation	SNP	G	A	A	rs121913287		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178916876G>A	uc003fjk.2	+	2	420	c.263G>A	c.(262-264)CGA>CAA	p.R88Q		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	88	PI3K-ABD.		R -> Q (in cancer; may disrupt the interaction between the PI3K-ABD domain and the N-terminal lobe of PI3K/PI4K kinase domain possibly affecting the conformation of the kinase domain).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R88Q(26)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			R88Q(SKUT1_SOFT_TISSUE)|R88Q(JHUEM1_ENDOMETRIUM)|R88Q(SNGM_ENDOMETRIUM)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178943836	178943836	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178943836A>G	uc003fjk.2	+							NM_006218	NP_006209			phosphoinositide-3-kinase, catalytic, alpha						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)				57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
MCF2L2	23101	broad.mit.edu	37	3	183017896	183017896	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183017896C>T	uc003fli.1	-	11	1292	c.1202G>A	c.(1201-1203)CGG>CAG	p.R401Q	MCF2L2_uc003flj.1_Missense_Mutation_p.R401Q|MCF2L2_uc011bqr.1_RNA|MCF2L2_uc003flp.1_3'UTR	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	401	Spectrin.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)															---	---	---	---
DGKG	1608	broad.mit.edu	37	3	185978308	185978308	+	Intron	SNP	G	A	A	rs111691516		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185978308G>A	uc003fqa.2	-						DGKG_uc003fqb.2_Intron|DGKG_uc003fqc.2_Intron|DGKG_uc011brx.1_Intron	NM_001346	NP_001337			diacylglycerol kinase gamma isoform 1						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)													---	---	---	---
TPRG1	285386	broad.mit.edu	37	3	189028328	189028328	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:189028328G>T	uc003frv.1	+	10	1860	c.633G>T	c.(631-633)AAG>AAT	p.K211N	TPRG1_uc003frw.1_Missense_Mutation_p.K211N	NM_198485	NP_940887	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	211											0	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)														---	---	---	---
GP5	2814	broad.mit.edu	37	3	194118298	194118298	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:194118298G>A	uc003ftv.1	-	2	745	c.714C>T	c.(712-714)TTC>TTT	p.F238F		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	238	Extracellular (Potential).|LRR 7.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)														---	---	---	---
ACAP2	23527	broad.mit.edu	37	3	195022892	195022892	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195022892C>G	uc003fun.3	-	14	1369	c.1128G>C	c.(1126-1128)AAG>AAC	p.K376N		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	376					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
MUC4	4585	broad.mit.edu	37	3	195497165	195497165	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195497165G>A	uc011bto.1	-	7	13396	c.12936C>T	c.(12934-12936)AAC>AAT	p.N4312N	MUC4_uc003fuz.2_Intron|MUC4_uc003fva.2_Translation_Start_Site|MUC4_uc003fvb.2_Translation_Start_Site|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Translation_Start_Site|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Silent_p.N4N|MUC4_uc011bti.1_Silent_p.N4N|MUC4_uc011btj.1_Silent_p.N181N|MUC4_uc011btk.1_Translation_Start_Site|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Silent_p.N204N|MUC4_uc003fvp.2_Silent_p.N153N|MUC4_uc010hzu.1_Silent_p.N1052N	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1197	NIDO.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)														---	---	---	---
LRCH3	84859	broad.mit.edu	37	3	197547200	197547200	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197547200T>C	uc011bul.1	+	4	544	c.539T>C	c.(538-540)GTG>GCG	p.V180A	LRCH3_uc003fyj.1_Missense_Mutation_p.V180A|LRCH3_uc011bum.1_Missense_Mutation_p.V180A|LRCH3_uc011bun.1_Intron	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	180	LRR 5.					extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)														---	---	---	---
ZNF718	255403	broad.mit.edu	37	4	155880	155880	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155880C>A	uc003fzt.3	+	8	1538	c.1405C>A	c.(1405-1407)CAT>AAT	p.H469N	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_3'UTR	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	469	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)														---	---	---	---
WHSC1	7468	broad.mit.edu	37	4	1962797	1962797	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1962797C>T	uc003gdz.3	+	18	3467	c.3291C>T	c.(3289-3291)ATC>ATT	p.I1097I	WHSC1_uc003geb.3_Silent_p.I1097I|WHSC1_uc003gec.3_Silent_p.I1097I|WHSC1_uc003ged.3_Silent_p.I1097I|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Silent_p.I316I|WHSC1_uc011bvh.1_Silent_p.I158I|WHSC1_uc010icf.2_Silent_p.I445I	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1097	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)				T	IGH@	MM								---	---	---	---
ADD1	118	broad.mit.edu	37	4	2899982	2899982	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2899982T>C	uc003gfr.2	+	7	1001	c.813T>C	c.(811-813)CAT>CAC	p.H271H	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Silent_p.H271H|ADD1_uc003gfo.2_Silent_p.H271H|ADD1_uc003gfp.2_Silent_p.H271H|ADD1_uc003gfq.2_Silent_p.H271H|ADD1_uc003gfs.2_Silent_p.H271H|ADD1_uc003gft.3_Silent_p.H271H|ADD1_uc003gfu.2_Silent_p.H21H	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	271					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)														---	---	---	---
EVC	2121	broad.mit.edu	37	4	5785435	5785435	+	Missense_Mutation	SNP	C	T	T	rs141820870		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5785435C>T	uc003gil.1	+	12	1904	c.1720C>T	c.(1720-1722)CGC>TGC	p.R574C	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	574					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)																---	---	---	---
EVC	2121	broad.mit.edu	37	4	5806514	5806514	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5806514C>T	uc003gil.1	+	17	2691	c.2507C>T	c.(2506-2508)TCG>TTG	p.S836L	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	836					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)																---	---	---	---
C4orf50	389197	broad.mit.edu	37	4	5982061	5982061	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5982061C>T	uc003git.1	-	2	98	c.8G>A	c.(7-9)CGG>CAG	p.R3Q		NM_207405	NP_997288	Q6ZRC1	CD050_HUMAN	hypothetical protein LOC389197	3										pancreas(2)|breast(1)	3																		---	---	---	---
MRFAP1L1	114932	broad.mit.edu	37	4	6711156	6711156	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:6711156G>C	uc003gjn.2	-	1	441	c.201C>G	c.(199-201)ATC>ATG	p.I67M	MRFAP1L1_uc003gjo.2_Missense_Mutation_p.I67M	NM_203462	NP_982287	Q96HT8	MR1L1_HUMAN	Morf4 family associated protein 1-like 1	67											0																		---	---	---	---
KIAA0232	9778	broad.mit.edu	37	4	6864819	6864819	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:6864819T>A	uc003gjr.3	+	7	3173	c.2710T>A	c.(2710-2712)TCA>ACA	p.S904T	KIAA0232_uc003gjq.3_Missense_Mutation_p.S904T	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	904							ATP binding			ovary(2)	2																		---	---	---	---
SORCS2	57537	broad.mit.edu	37	4	7666180	7666180	+	Silent	SNP	C	T	T	rs35935435	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:7666180C>T	uc003gkb.3	+	7	1053	c.1053C>T	c.(1051-1053)GAC>GAT	p.D351D	SORCS2_uc011bwi.1_Silent_p.D179D	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	351	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
ACOX3	8310	broad.mit.edu	37	4	8411994	8411994	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:8411994G>A	uc010idk.2	-	6	777	c.632C>T	c.(631-633)GCT>GTT	p.A211V	ACOX3_uc003glc.3_Missense_Mutation_p.A211V|ACOX3_uc003gld.3_Missense_Mutation_p.A211V|ACOX3_uc003gle.1_Missense_Mutation_p.A116V	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	211					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1																		---	---	---	---
LDB2	9079	broad.mit.edu	37	4	16900030	16900030	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:16900030G>A	uc003goz.2	-	1	395	c.79C>T	c.(79-81)CAG>TAG	p.Q27*	LDB2_uc003gpa.2_Nonsense_Mutation_p.Q27*|LDB2_uc003gpb.2_Nonsense_Mutation_p.Q27*|LDB2_uc011bxh.1_Nonsense_Mutation_p.Q27*|LDB2_uc010iee.2_Nonsense_Mutation_p.Q27*	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	27							LIM domain binding|transcription cofactor activity				0																		---	---	---	---
NCAPG	64151	broad.mit.edu	37	4	17819716	17819716	+	Intron	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:17819716A>T	uc003gpp.2	+						NCAPG_uc011bxj.1_Intron	NM_022346	NP_071741			chromosome condensation protein G						cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)														---	---	---	---
SLIT2	9353	broad.mit.edu	37	4	20620460	20620460	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:20620460C>G	uc003gpr.1	+	37	4622	c.4418C>G	c.(4417-4419)ACA>AGA	p.T1473R	SLIT2_uc003gps.1_Missense_Mutation_p.T1465R	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1473	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11																		---	---	---	---
GPR125	166647	broad.mit.edu	37	4	22415322	22415322	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22415322C>T	uc003gqm.1	-	13	2190	c.1925G>A	c.(1924-1926)CGC>CAC	p.R642H	GPR125_uc010ieo.1_Missense_Mutation_p.R498H	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	642	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)																---	---	---	---
PPARGC1A	10891	broad.mit.edu	37	4	23830129	23830129	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:23830129G>A	uc003gqs.2	-	5	771	c.651C>T	c.(649-651)AAC>AAT	p.N217N	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	217					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)																---	---	---	---
ANAPC4	29945	broad.mit.edu	37	4	25404657	25404657	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25404657A>G	uc003gro.2	+						ANAPC4_uc003grp.2_Intron	NM_013367	NP_037499			anaphase-promoting complex subunit 4						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)																---	---	---	---
FAM114A1	92689	broad.mit.edu	37	4	38910256	38910256	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:38910256T>C	uc003gtn.2	+	7	877	c.701T>C	c.(700-702)ATC>ACC	p.I234T	FAM114A1_uc011byh.1_Missense_Mutation_p.I27T	NM_138389	NP_612398	Q8IWE2	NXP20_HUMAN	hypothetical protein LOC92689	234						cytoplasm				ovary(1)	1																		---	---	---	---
FAM114A1	92689	broad.mit.edu	37	4	38910296	38910296	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:38910296G>A	uc003gtn.2	+	7	917	c.741G>A	c.(739-741)CCG>CCA	p.P247P	FAM114A1_uc011byh.1_Silent_p.P40P	NM_138389	NP_612398	Q8IWE2	NXP20_HUMAN	hypothetical protein LOC92689	247						cytoplasm				ovary(1)	1																		---	---	---	---
KLHL5	51088	broad.mit.edu	37	4	39104951	39104951	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39104951A>G	uc003gts.2	+	7	1558	c.1483A>G	c.(1483-1485)ACT>GCT	p.T495A	KLHL5_uc003gtp.2_Missense_Mutation_p.T449A|KLHL5_uc003gtq.2_Missense_Mutation_p.T308A|KLHL5_uc003gtr.1_Missense_Mutation_p.T495A|KLHL5_uc003gtt.2_Missense_Mutation_p.T434A	NM_015990	NP_057074	Q96PQ7	KLHL5_HUMAN	kelch-like 5 isoform 1	495	Kelch 1.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1																		---	---	---	---
UGDH	7358	broad.mit.edu	37	4	39512462	39512462	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39512462G>T	uc003guk.1	-	4	600	c.284C>A	c.(283-285)ACC>AAC	p.T95N	UGDH_uc011byp.1_5'UTR|UGDH_uc003gul.1_Intron	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	95					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)													---	---	---	---
LIMCH1	22998	broad.mit.edu	37	4	41687824	41687824	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:41687824C>T	uc003gvu.3	+	23	2967	c.2913C>T	c.(2911-2913)ATC>ATT	p.I971I	LIMCH1_uc003gvv.3_Silent_p.I971I|LIMCH1_uc003gvw.3_Silent_p.I970I|LIMCH1_uc003gvx.3_Silent_p.I983I|LIMCH1_uc003gwe.3_Silent_p.I894I|LIMCH1_uc003gvy.3_Silent_p.I799I|LIMCH1_uc003gwa.3_Silent_p.I811I|LIMCH1_uc003gvz.3_Silent_p.I1355I|LIMCH1_uc011byu.1_Silent_p.I804I|LIMCH1_uc003gwc.3_Silent_p.I816I|LIMCH1_uc003gwd.3_Silent_p.I804I|LIMCH1_uc011byv.1_Silent_p.I721I|LIMCH1_uc011byw.1_Silent_p.I270I	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	971					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
LIMCH1	22998	broad.mit.edu	37	4	41691639	41691639	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:41691639T>C	uc003gvu.3	+	25	3164	c.3110T>C	c.(3109-3111)ATC>ACC	p.I1037T	LIMCH1_uc003gvv.3_Missense_Mutation_p.I1011T|LIMCH1_uc003gvw.3_Missense_Mutation_p.I1010T|LIMCH1_uc003gvx.3_Missense_Mutation_p.I1023T|LIMCH1_uc003gwe.3_Missense_Mutation_p.I934T|LIMCH1_uc003gvy.3_Missense_Mutation_p.I839T|LIMCH1_uc003gwa.3_Missense_Mutation_p.I851T|LIMCH1_uc003gvz.3_Missense_Mutation_p.I1421T|LIMCH1_uc011byu.1_Missense_Mutation_p.I870T|LIMCH1_uc003gwc.3_Missense_Mutation_p.I856T|LIMCH1_uc003gwd.3_Missense_Mutation_p.I844T|LIMCH1_uc011byv.1_Missense_Mutation_p.I787T|LIMCH1_uc011byw.1_Missense_Mutation_p.I310T	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	1037	LIM zinc-binding.				actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
DCAF4L1	285429	broad.mit.edu	37	4	41984149	41984149	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:41984149G>T	uc003gwk.2	+	1	437	c.340G>T	c.(340-342)GTG>TTG	p.V114L		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	114										skin(1)	1																		---	---	---	---
PDGFRA	5156	broad.mit.edu	37	4	54244047	54244047	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:54244047C>T	uc003haa.2	+	1	228	c.42C>T	c.(40-42)AGC>AGT	p.S14S	FIP1L1_uc003gzx.3_Silent_p.S14S|FIP1L1_uc011bzt.1_Silent_p.S14S|FIP1L1_uc003gzy.2_Silent_p.S14S|FIP1L1_uc011bzu.1_Silent_p.S14S|FIP1L1_uc003gzz.2_Silent_p.S14S|FIP1L1_uc003hab.2_5'UTR	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	Error:Variant_position_missing_in_P16234_after_alignment					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			---	---	---	---
GSX2	170825	broad.mit.edu	37	4	54967794	54967794	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:54967794C>T	uc010igp.1	+	2	884	c.620C>T	c.(619-621)ACG>ATG	p.T207M	PDGFRA_uc003haa.2_Intron	NM_133267	NP_573574	Q9BZM3	GSX2_HUMAN	GS homeobox 2	207	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)															---	---	---	---
KIT	3815	broad.mit.edu	37	4	55569973	55569973	+	Silent	SNP	G	A	A	rs142772432		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:55569973G>A	uc010igr.2	+	5	927	c.840G>A	c.(838-840)GCG>GCA	p.A280A	KIT_uc010igs.2_Silent_p.A280A	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	280	Extracellular (Potential).|Ig-like C2-type 3.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				---	---	---	---
EPHA5	2044	broad.mit.edu	37	4	66356166	66356166	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:66356166A>T	uc003hcy.2	-	5	1524	c.1331T>A	c.(1330-1332)GTG>GAG	p.V444E	EPHA5_uc003hcx.2_Missense_Mutation_p.V375E|EPHA5_uc003hcz.2_Missense_Mutation_p.V444E|EPHA5_uc011cah.1_Missense_Mutation_p.V444E|EPHA5_uc011cai.1_Missense_Mutation_p.V444E|EPHA5_uc003hda.2_Missense_Mutation_p.V444E	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	444	Fibronectin type-III 1.|Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24															TSP Lung(17;0.13)			---	---	---	---
TMPRSS11A	339967	broad.mit.edu	37	4	68812182	68812182	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68812182T>C	uc003hdr.1	-	2	240	c.119A>G	c.(118-120)CAC>CGC	p.H40R	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.H40R	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	40	Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1																		---	---	---	---
SULT1E1	6783	broad.mit.edu	37	4	70719960	70719960	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:70719960G>A	uc003heo.2	-	4	457	c.344C>T	c.(343-345)GCC>GTC	p.A115V	SULT1E1_uc010ihv.1_Missense_Mutation_p.A115V	NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	115					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1																		---	---	---	---
AMBN	258	broad.mit.edu	37	4	71472342	71472342	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71472342C>T	uc003hfl.2	+	13	1314	c.1239C>T	c.(1237-1239)ACC>ACT	p.T413T		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	413					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)															---	---	---	---
SLC4A4	8671	broad.mit.edu	37	4	72338444	72338444	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:72338444C>T	uc003hfy.2	+	14	1777	c.1660C>T	c.(1660-1662)CGC>TGC	p.R554C	SLC4A4_uc010iic.2_Missense_Mutation_p.R554C|SLC4A4_uc010iib.2_Missense_Mutation_p.R554C|SLC4A4_uc003hfz.2_Missense_Mutation_p.R554C|SLC4A4_uc003hgc.3_Missense_Mutation_p.R510C|SLC4A4_uc010iid.2_Intron|SLC4A4_uc003hga.2_Missense_Mutation_p.R432C|SLC4A4_uc003hgb.3_Missense_Mutation_p.R510C	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	554	Cytoplasmic (Potential).		R -> H (in pRTA-OA; mistargeting and altered function).	R->D: Prevents membrane targeting.		basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)															---	---	---	---
NAAA	27163	broad.mit.edu	37	4	76836121	76836121	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76836121G>A	uc003hjb.2	-	10	1080	c.1016C>T	c.(1015-1017)ACG>ATG	p.T339M	NAAA_uc003hja.2_Intron	NM_014435	NP_055250	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase isoform 1	339					lipid metabolic process	lysosome	hydrolase activity			skin(1)	1																		---	---	---	---
GK2	2712	broad.mit.edu	37	4	80329115	80329115	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:80329115A>G	uc003hlu.2	-	1	258	c.240T>C	c.(238-240)ATT>ATC	p.I80I		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	80					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4																		---	---	---	---
PRDM8	56978	broad.mit.edu	37	4	81123201	81123201	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:81123201C>T	uc010ijo.2	+	8	1424	c.585C>T	c.(583-585)GGC>GGT	p.G195G	PRDM8_uc003hmb.3_Silent_p.G195G|PRDM8_uc003hmc.3_Silent_p.G195G	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	195	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1																OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RASGEF1B	153020	broad.mit.edu	37	4	82355838	82355838	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:82355838A>G	uc003hmi.1	-	11	1299	c.1155T>C	c.(1153-1155)AAT>AAC	p.N385N	RASGEF1B_uc003hmj.1_Silent_p.N384N|RASGEF1B_uc010ijq.1_Silent_p.N343N	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	385	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0																		---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85609395	85609395	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85609395G>A	uc003hpd.2	-	62	9795	c.9387C>T	c.(9385-9387)ACC>ACT	p.T3129T		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	3129	WD 2.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85722917	85722917	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85722917C>T	uc003hpd.2	-	17	3116	c.2708G>A	c.(2707-2709)CGA>CAA	p.R903Q		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	903						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
C4orf36	132989	broad.mit.edu	37	4	87808959	87808959	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87808959A>G	uc003hqe.3	-	4	621	c.308T>C	c.(307-309)CTG>CCG	p.L103P		NM_144645	NP_653246	Q96KX1	CD036_HUMAN	hypothetical protein LOC132989	103											0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00141)														---	---	---	---
AFF1	4299	broad.mit.edu	37	4	87968255	87968255	+	Nonsense_Mutation	SNP	G	T	T	rs148083475		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87968255G>T	uc003hqj.3	+	3	954	c.547G>T	c.(547-549)GGA>TGA	p.G183*	AFF1_uc011ccx.1_Nonsense_Mutation_p.G124*|AFF1_uc003hqh.1_Nonsense_Mutation_p.G190*|AFF1_uc011ccy.1_Nonsense_Mutation_p.G190*|AFF1_uc011ccz.1_Nonsense_Mutation_p.G190*|AFF1_uc003hqk.3_Nonsense_Mutation_p.G183*|AFF1_uc011cda.1_Intron	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	183						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)														---	---	---	---
DSPP	1834	broad.mit.edu	37	4	88533595	88533595	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88533595C>A	uc003hqu.2	+	4	377	c.257C>A	c.(256-258)GCA>GAA	p.A86E		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	86					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)														---	---	---	---
MMRN1	22915	broad.mit.edu	37	4	90830464	90830464	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:90830464A>G	uc003hst.2	+	2	732	c.661A>G	c.(661-663)ACA>GCA	p.T221A	MMRN1_uc010iku.2_Missense_Mutation_p.T187A|MMRN1_uc011cds.1_5'UTR	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	221	EMI.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)														---	---	---	---
SMARCAD1	56916	broad.mit.edu	37	4	95199819	95199819	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:95199819C>T	uc003htc.3	+	18	2486	c.2231C>T	c.(2230-2232)TCG>TTG	p.S744L	SMARCAD1_uc003htb.3_Missense_Mutation_p.S744L|SMARCAD1_uc003htd.3_Missense_Mutation_p.S744L|SMARCAD1_uc010ila.2_Missense_Mutation_p.S607L|SMARCAD1_uc011cdw.1_Missense_Mutation_p.S314L	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	744					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)														---	---	---	---
METAP1	23173	broad.mit.edu	37	4	99962266	99962266	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:99962266G>A	uc003huf.3	+	6	622	c.505G>A	c.(505-507)GCT>ACT	p.A169T	METAP1_uc003hug.2_RNA	NM_015143	NP_055958	P53582	AMPM1_HUMAN	methionyl aminopeptidase 1	169					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis|regulation of translation	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(123;3.12e-07)														---	---	---	---
NPNT	255743	broad.mit.edu	37	4	106863655	106863655	+	Missense_Mutation	SNP	A	G	G	rs144959760	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106863655A>G	uc003hya.2	+	8	1160	c.955A>G	c.(955-957)ACA>GCA	p.T319A	NPNT_uc011cfc.1_Missense_Mutation_p.T336A|NPNT_uc011cfd.1_Missense_Mutation_p.T349A|NPNT_uc011cfe.1_Missense_Mutation_p.T349A|NPNT_uc010ilt.1_Missense_Mutation_p.T319A|NPNT_uc011cff.1_Missense_Mutation_p.T319A|NPNT_uc010ilu.1_Missense_Mutation_p.T215A	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	319	Pro-rich.				cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)														---	---	---	---
DKK2	27123	broad.mit.edu	37	4	107845698	107845698	+	Intron	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:107845698C>A	uc003hyi.2	-						DKK2_uc003hyj.1_Missense_Mutation_p.R178M	NM_014421	NP_055236			dickkopf homolog 2 precursor						multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)														---	---	---	---
ENPEP	2028	broad.mit.edu	37	4	111397859	111397859	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:111397859G>A	uc003iab.3	+	1	631	c.289G>A	c.(289-291)GTC>ATC	p.V97I		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	97	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)													---	---	---	---
NDST3	9348	broad.mit.edu	37	4	118975701	118975701	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:118975701A>G	uc003ibx.2	+	2	1039	c.636A>G	c.(634-636)AAA>AAG	p.K212K	NDST3_uc011cgf.1_Silent_p.K212K|NDST3_uc003ibw.2_Silent_p.K212K	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	212	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1																		---	---	---	---
PRSS12	8492	broad.mit.edu	37	4	119237471	119237471	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119237471G>A	uc003ica.1	-	6	1205	c.1158C>T	c.(1156-1158)GTC>GTT	p.V386V		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	386						membrane	scavenger receptor activity			skin(1)	1																		---	---	---	---
EXOSC9	5393	broad.mit.edu	37	4	122731160	122731160	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122731160G>A	uc003iea.2	+	7	752	c.644G>A	c.(643-645)CGT>CAT	p.R215H	EXOSC9_uc003idz.2_Missense_Mutation_p.R215H|EXOSC9_uc003ieb.2_Missense_Mutation_p.R199H|EXOSC9_uc010inp.1_RNA	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	215	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123171679	123171679	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123171679G>A	uc003ieh.2	+	35	5918	c.5873G>A	c.(5872-5874)CGG>CAG	p.R1958Q	KIAA1109_uc003iek.2_Missense_Mutation_p.R577Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1958					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126328095	126328095	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126328095G>A	uc003ifj.3	+	3	5368	c.5368G>A	c.(5368-5370)GAC>AAC	p.D1790N	FAT4_uc011cgp.1_Missense_Mutation_p.D88N	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1790	Cadherin 17.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
PCDH10	57575	broad.mit.edu	37	4	134072881	134072881	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:134072881G>A	uc003iha.2	+	1	2412	c.1586G>A	c.(1585-1587)CGC>CAC	p.R529H	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.R529H	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	529	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)														---	---	---	---
NAA15	80155	broad.mit.edu	37	4	140275179	140275179	+	Splice_Site	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:140275179G>T	uc003ihu.1	+	10	1271	c.1015_splice	c.e10-1	p.V339_splice		NM_057175	NP_476516			NMDA receptor regulated 1						angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2																		---	---	---	---
ARHGAP10	79658	broad.mit.edu	37	4	148984398	148984398	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:148984398G>A	uc003ilf.2	+	21	2127	c.2127G>A	c.(2125-2127)TCG>TCA	p.S709S	ARHGAP10_uc003ilg.2_Intron|ARHGAP10_uc003ilh.2_Silent_p.S290S|ARHGAP10_uc003ili.2_Silent_p.S142S	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	709					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)														---	---	---	---
DCLK2	166614	broad.mit.edu	37	4	151169505	151169505	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151169505G>A	uc003ilm.3	+	14	2024	c.1924G>A	c.(1924-1926)GCG>ACG	p.A642T	DCLK2_uc003iln.3_Missense_Mutation_p.A641T|DCLK2_uc003ilo.3_Missense_Mutation_p.A659T|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	642	Protein kinase.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)																	---	---	---	---
TIGD4	201798	broad.mit.edu	37	4	153691221	153691221	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:153691221A>G	uc003imy.2	-	2	1718	c.936T>C	c.(934-936)TCT>TCC	p.S312S		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	312	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)																	---	---	---	---
KIAA0922	23240	broad.mit.edu	37	4	154519856	154519856	+	Silent	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154519856C>A	uc003inm.3	+	21	2287	c.2235C>A	c.(2233-2235)CCC>CCA	p.P745P	KIAA0922_uc010ipp.2_Silent_p.P746P|KIAA0922_uc010ipq.2_Silent_p.P514P	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	745	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)																---	---	---	---
GRIA2	2891	broad.mit.edu	37	4	158224771	158224771	+	Silent	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:158224771C>A	uc003ipm.3	+	3	756	c.297C>A	c.(295-297)ACC>ACA	p.T99T	GRIA2_uc011cit.1_Silent_p.T52T|GRIA2_uc003ipl.3_Silent_p.T99T|GRIA2_uc003ipk.3_Silent_p.T52T|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	99	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)													---	---	---	---
TLL1	7092	broad.mit.edu	37	4	166981351	166981351	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166981351A>G	uc003irh.1	+						TLL1_uc011cjn.1_Intron|TLL1_uc011cjo.1_Intron	NM_012464	NP_036596			tolloid-like 1 precursor						cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)														---	---	---	---
CCDC111	201973	broad.mit.edu	37	4	185599425	185599425	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185599425C>A	uc003iwk.2	+	8	1317	c.884C>A	c.(883-885)TCA>TAA	p.S295*	CCDC111_uc010isd.1_RNA|CCDC111_uc003iwj.2_Nonsense_Mutation_p.S295*|CCDC111_uc003iwl.2_Nonsense_Mutation_p.S295*|CCDC111_uc003iwm.2_Nonsense_Mutation_p.S166*|CCDC111_uc003iwn.2_Intron	NM_152683	NP_689896	Q96LW4	CC111_HUMAN	coiled-coil domain containing 111	295					DNA replication, synthesis of RNA primer		DNA primase activity			central_nervous_system(1)	1		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)														---	---	---	---
AHRR	57491	broad.mit.edu	37	5	424025	424025	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:424025C>T	uc003jav.2	+	7	697	c.653C>T	c.(652-654)TCG>TTG	p.S218L	AHRR_uc003jaw.2_Missense_Mutation_p.S214L|AHRR_uc010isy.2_Missense_Mutation_p.S64L|AHRR_uc010isz.2_Missense_Mutation_p.S214L|AHRR_uc003jax.2_5'UTR|AHRR_uc003jay.2_Missense_Mutation_p.S74L	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	218					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)															---	---	---	---
IRX4	50805	broad.mit.edu	37	5	1879766	1879766	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1879766C>T	uc003jcz.2	-	4	707	c.588G>A	c.(586-588)GCG>GCA	p.A196A	IRX4_uc011cmf.1_Silent_p.A57A	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	196	Homeobox; TALE-type.				heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)														---	---	---	---
CCT5	22948	broad.mit.edu	37	5	10264815	10264815	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:10264815C>T	uc003jeq.2	+	11	1717	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	CCT5_uc003jer.2_3'UTR|CCT5_uc010its.2_3'UTR|CCT5_uc011cmr.1_Nonsense_Mutation_p.Q461*|CCT5_uc011cms.1_Nonsense_Mutation_p.Q478*|CCT5_uc011cmt.1_Nonsense_Mutation_p.Q423*	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	516					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2																		---	---	---	---
DNAH5	1767	broad.mit.edu	37	5	13786321	13786321	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13786321C>T	uc003jfd.2	-	52	8829	c.8787G>A	c.(8785-8787)GTG>GTA	p.V2929V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2929	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---
TRIO	7204	broad.mit.edu	37	5	14419959	14419959	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:14419959C>T	uc003jff.2	+	34	5038	c.5032C>T	c.(5032-5034)CGA>TGA	p.R1678*	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Nonsense_Mutation_p.R1327*	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1678	SH3 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)																	---	---	---	---
BASP1	10409	broad.mit.edu	37	5	17275415	17275415	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:17275415G>A	uc003jfx.2	+	2	269	c.90G>A	c.(88-90)GCG>GCA	p.A30A		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	30					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0																		---	---	---	---
CDH18	1016	broad.mit.edu	37	5	19591227	19591227	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:19591227A>G	uc003jgc.2	-	6	1315	c.938T>C	c.(937-939)ATG>ACG	p.M313T	CDH18_uc003jgd.2_Missense_Mutation_p.M313T|CDH18_uc011cnm.1_Missense_Mutation_p.M313T	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	313	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)																	---	---	---	---
CDH12	1010	broad.mit.edu	37	5	21842351	21842351	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:21842351G>A	uc010iuc.2	-	5	1191	c.733C>T	c.(733-735)CAG>TAG	p.Q245*	CDH12_uc011cno.1_Nonsense_Mutation_p.Q205*|CDH12_uc003jgk.2_Nonsense_Mutation_p.Q245*	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	245	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2															HNSCC(59;0.17)			---	---	---	---
RNASEN	29102	broad.mit.edu	37	5	31526774	31526774	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31526774G>A	uc003jhg.2	-	4	625	c.266C>T	c.(265-267)GCG>GTG	p.A89V	RNASEN_uc003jhh.2_Missense_Mutation_p.A89V|RNASEN_uc003jhi.2_Missense_Mutation_p.A89V|RNASEN_uc010iui.1_Missense_Mutation_p.A80V	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	89	Pro-rich.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0																		---	---	---	---
PDZD2	23037	broad.mit.edu	37	5	32058117	32058117	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32058117C>T	uc003jhl.2	+	12	2496	c.2108C>T	c.(2107-2109)GCG>GTG	p.A703V	PDZD2_uc003jhm.2_Missense_Mutation_p.A703V|PDZD2_uc011cnx.1_Missense_Mutation_p.A529V	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	703					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9																		---	---	---	---
AMACR	23600	broad.mit.edu	37	5	33989221	33989221	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33989221T>C	uc003jig.2	-	5	1208	c.1126A>G	c.(1126-1128)AAT>GAT	p.N376D	AMACR_uc003jih.2_3'UTR|AMACR_uc003jii.2_Missense_Mutation_p.N361D|AMACR_uc003jij.2_Missense_Mutation_p.N376D	NM_014324	NP_055139	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase isoform 1	376					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity				0																		---	---	---	---
C1QTNF3	114899	broad.mit.edu	37	5	34033499	34033499	+	Silent	SNP	G	A	A	rs147942281	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:34033499G>A	uc003jin.2	-	3	348	c.261C>T	c.(259-261)GGC>GGT	p.G87G	C1QTNF3_uc003jio.2_Silent_p.G160G	NM_030945	NP_112207	Q9BXJ4	C1QT3_HUMAN	C1q and tumor necrosis factor related protein 3	87	Collagen-like.					collagen					0	all_lung(31;0.0207)																	---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	37000602	37000602	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37000602T>C	uc003jkl.3	+	12	3931	c.3432T>C	c.(3430-3432)GGT>GGC	p.G1144G	NIPBL_uc003jkk.3_Silent_p.G1144G	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1144					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
C5orf42	65250	broad.mit.edu	37	5	37120454	37120454	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37120454A>G	uc011cpa.1	-						C5orf42_uc003jko.1_Intron|C5orf42_uc003jkp.1_Intron|C5orf42_uc011coy.1_Intron|C5orf42_uc003jks.2_Intron|C5orf42_uc011coz.1_Intron	NM_023073	NP_075561			hypothetical protein LOC65250											ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)															---	---	---	---
NUP155	9631	broad.mit.edu	37	5	37350336	37350336	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37350336C>T	uc003jku.1	-	7	873	c.755G>A	c.(754-756)AGG>AAG	p.R252K	NUP155_uc003jkt.1_Missense_Mutation_p.R193K|NUP155_uc010iuz.1_Missense_Mutation_p.R252K	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	252					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
GDNF	2668	broad.mit.edu	37	5	37815867	37815867	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37815867T>C	uc011cpi.1	-	3	722	c.522A>G	c.(520-522)GTA>GTG	p.V174V	GDNF_uc011cpc.1_Silent_p.V96V|GDNF_uc011cpd.1_Silent_p.V122V|GDNF_uc011cpe.1_Silent_p.V148V|GDNF_uc011cpf.1_Silent_p.V148V|GDNF_uc011cpg.1_Silent_p.V191V|GDNF_uc011cph.1_Silent_p.V165V	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	174					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)																	---	---	---	---
C6	729	broad.mit.edu	37	5	41149542	41149542	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:41149542G>A	uc003jmk.2	-	17	2634	c.2424C>T	c.(2422-2424)AAC>AAT	p.N808N	C6_uc003jml.1_Silent_p.N808N	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	808	C5b-binding domain.|Complement control factor I module 1.|Kazal-like 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)																---	---	---	---
GPBP1	65056	broad.mit.edu	37	5	56527097	56527097	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:56527097C>T	uc003jrh.3	+	5	1634	c.360C>T	c.(358-360)ACC>ACT	p.T120T	GPBP1_uc010iwg.2_Silent_p.T120T|GPBP1_uc003jri.3_5'UTR|GPBP1_uc003jrj.3_Silent_p.T127T|GPBP1_uc003jrk.3_Silent_p.T127T|GPBP1_uc003jrl.3_RNA	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)														---	---	---	---
GPBP1	65056	broad.mit.edu	37	5	56546783	56546783	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:56546783T>C	uc003jrh.3	+	10	2249	c.975T>C	c.(973-975)GAT>GAC	p.D325D	GPBP1_uc010iwg.2_Silent_p.D345D|GPBP1_uc003jri.3_Silent_p.D154D|GPBP1_uc003jrj.3_Silent_p.D317D|GPBP1_uc003jrk.3_Silent_p.D332D|GPBP1_uc003jrl.3_RNA	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)														---	---	---	---
HTR1A	3350	broad.mit.edu	37	5	63256803	63256803	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:63256803C>T	uc011cqt.1	-	1	744	c.744G>A	c.(742-744)CCG>CCA	p.P248P		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	248	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)													---	---	---	---
TRIM23	373	broad.mit.edu	37	5	64910016	64910016	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64910016T>A	uc003jty.2	-	3	361	c.275A>T	c.(274-276)AAT>ATT	p.N92I	TRIM23_uc003jtw.2_Missense_Mutation_p.N92I|TRIM23_uc003jtx.2_Missense_Mutation_p.N92I	NM_001656	NP_001647	P36406	TRI23_HUMAN	ADP-ribosylation factor domain protein 1 isoform	92					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)														---	---	---	---
ERBB2IP	55914	broad.mit.edu	37	5	65320250	65320250	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65320250T>G	uc003juk.1	+	10	1097	c.789T>G	c.(787-789)AAT>AAG	p.N263K	ERBB2IP_uc003juh.1_Missense_Mutation_p.N263K|ERBB2IP_uc003jui.1_Missense_Mutation_p.N263K|ERBB2IP_uc003juj.1_Missense_Mutation_p.N263K|ERBB2IP_uc011cqx.1_Missense_Mutation_p.N263K|ERBB2IP_uc011cqy.1_Missense_Mutation_p.N263K|ERBB2IP_uc011cqz.1_Missense_Mutation_p.N263K|ERBB2IP_uc010iwx.1_Missense_Mutation_p.N263K|ERBB2IP_uc003jul.1_Missense_Mutation_p.N263K	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	263	LRR 11.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)														---	---	---	---
MAST4	375449	broad.mit.edu	37	5	66448592	66448592	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:66448592G>A	uc003jut.1	+	24	2924	c.2856G>A	c.(2854-2856)CCG>CCA	p.P952P	MAST4_uc003juw.2_Silent_p.P880P	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1144	PDZ.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)														---	---	---	---
MAP1B	4131	broad.mit.edu	37	5	71491093	71491093	+	Silent	SNP	G	A	A	rs140902387	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:71491093G>A	uc003kbw.3	+	5	2152	c.1911G>A	c.(1909-1911)ACG>ACA	p.T637T	MAP1B_uc010iyw.1_Silent_p.T654T|MAP1B_uc010iyx.1_Silent_p.T511T|MAP1B_uc010iyy.1_Silent_p.T511T	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	637	Lys-rich (highly basic, contains many KKEE and KKEI/V repeats).					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)														---	---	---	---
RGNEF	64283	broad.mit.edu	37	5	73163798	73163798	+	Silent	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:73163798A>T	uc011csq.1	+	18	2261	c.2250A>T	c.(2248-2250)GGA>GGT	p.G750G	RGNEF_uc003kcx.2_Silent_p.G750G|RGNEF_uc010izf.2_Silent_p.G750G|RGNEF_uc011csr.1_Silent_p.G437G	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	750					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)														---	---	---	---
AGGF1	55109	broad.mit.edu	37	5	76344774	76344774	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:76344774G>C	uc003ket.2	+	8	1687	c.1327G>C	c.(1327-1329)GAA>CAA	p.E443Q		NM_018046	NP_060516	Q8N302	AGGF1_HUMAN	angiogenic factor VG5Q	443	FHA.				angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)														---	---	---	---
SCAMP1	9522	broad.mit.edu	37	5	77717683	77717683	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:77717683T>C	uc003kfl.2	+	6	688	c.531T>C	c.(529-531)GAT>GAC	p.D177D	SCAMP1_uc010jaa.2_Intron|SCAMP1_uc011ctc.1_RNA|SCAMP1_uc011ctd.1_RNA|SCAMP1_uc003kfm.2_RNA	NM_004866	NP_004857	O15126	SCAM1_HUMAN	secretory carrier membrane protein 1	177	Lumenal (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane|recycling endosome membrane|trans-Golgi network	protein binding				0		all_lung(232;0.000397)|Lung NSC(167;0.00105)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;1.9e-46)|Epithelial(54;9.4e-43)|all cancers(79;1.12e-37)														---	---	---	---
CMYA5	202333	broad.mit.edu	37	5	79031505	79031505	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79031505T>C	uc003kgc.2	+	2	6989	c.6917T>C	c.(6916-6918)GTA>GCA	p.V2306A		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2306						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)														---	---	---	---
ZFYVE16	9765	broad.mit.edu	37	5	79735824	79735824	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79735824G>A	uc003kgr.3	+	5	2694	c.2392G>A	c.(2392-2394)GTA>ATA	p.V798I	ZFYVE16_uc010jak.1_Missense_Mutation_p.V798I|ZFYVE16_uc003kgp.2_Missense_Mutation_p.V798I|ZFYVE16_uc003kgq.3_Missense_Mutation_p.V798I|ZFYVE16_uc003kgs.3_Missense_Mutation_p.V798I	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	798	FYVE-type.				BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)														---	---	---	---
XRCC4	7518	broad.mit.edu	37	5	82400785	82400785	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82400785T>A	uc003kib.2	+	2	175	c.47T>A	c.(46-48)ATA>AAA	p.I16K	XRCC4_uc003kia.1_Missense_Mutation_p.I16K|XRCC4_uc003kid.2_Missense_Mutation_p.I16K|XRCC4_uc003kic.2_Missense_Mutation_p.I16K|XRCC4_uc003kie.2_Missense_Mutation_p.I16K|XRCC4_uc003kif.1_Missense_Mutation_p.I16K	NM_022406	NP_071801	Q13426	XRCC4_HUMAN	X-ray repair cross complementing protein 4	16					DNA ligation involved in DNA repair|double-strand break repair via nonhomologous end joining|initiation of viral infection|positive regulation of ligase activity|provirus integration|response to X-ray	cytosol|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|nucleoplasm	DNA binding|protein C-terminus binding			skin(3)	3		Lung NSC(167;0.00132)|all_lung(232;0.00154)|Ovarian(174;0.034)		OV - Ovarian serous cystadenocarcinoma(54;1.44e-38)|Epithelial(54;3.72e-33)|all cancers(79;9.22e-28)									NHEJ					---	---	---	---
EDIL3	10085	broad.mit.edu	37	5	83360539	83360539	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:83360539A>C	uc003kio.1	-	8	1351	c.932T>G	c.(931-933)CTT>CGT	p.L311R	EDIL3_uc003kip.1_Missense_Mutation_p.L301R|EDIL3_uc011ctt.1_Missense_Mutation_p.L88R	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	311	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	89924611	89924611	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89924611A>G	uc003kju.2	+	8	1567	c.1471A>G	c.(1471-1473)ACA>GCA	p.T491A	GPR98_uc003kjt.2_Translation_Start_Site	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	491	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
FAM172A	83989	broad.mit.edu	37	5	93386492	93386492	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:93386492T>G	uc010jbd.2	-	4	460	c.253A>C	c.(253-255)AAC>CAC	p.N85H	FAM172A_uc011cuf.1_Missense_Mutation_p.N39H|FAM172A_uc011cug.1_Missense_Mutation_p.N39H|FAM172A_uc011cuh.1_Intron|FAM172A_uc011cui.1_Intron|FAM172A_uc011cuj.1_Intron|FAM172A_uc003kkm.3_Missense_Mutation_p.N85H	NM_032042	NP_114431	Q8WUF8	F172A_HUMAN	hypothetical protein LOC83989 isoform 1	85						endoplasmic reticulum|extracellular region					0																		---	---	---	---
TSLP	85480	broad.mit.edu	37	5	110409325	110409325	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110409325A>G	uc003kpb.2	+	3	532	c.333A>G	c.(331-333)CCA>CCG	p.P111P	TSLP_uc003kpa.2_RNA|TSLP_uc010jbt.1_Silent_p.P15P	NM_033035	NP_149024	Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin isoform 1	111						extracellular space	cytokine activity				0		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)														---	---	---	---
FAM170A	340069	broad.mit.edu	37	5	118970280	118970280	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118970280G>A	uc003ksm.2	+	3	1047	c.837G>A	c.(835-837)GAG>GAA	p.E279E	FAM170A_uc003ksl.2_Intron|FAM170A_uc003ksn.2_Silent_p.E279E|FAM170A_uc003kso.2_Silent_p.E232E	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	279	Glu-rich.					intracellular	zinc ion binding			skin(1)	1																		---	---	---	---
SRFBP1	153443	broad.mit.edu	37	5	121309939	121309939	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:121309939C>T	uc003kst.1	+	2	157	c.85C>T	c.(85-87)CGA>TGA	p.R29*		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)														---	---	---	---
ZNF474	133923	broad.mit.edu	37	5	121488306	121488306	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:121488306C>T	uc003ksv.2	+	2	997	c.621C>T	c.(619-621)GGC>GGT	p.G207G		NM_207317	NP_997200	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	207						intracellular	zinc ion binding				0		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)														---	---	---	---
FBN2	2201	broad.mit.edu	37	5	127728848	127728848	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127728848C>T	uc003kuu.2	-	10	1884	c.1445G>A	c.(1444-1446)GGA>GAA	p.G482E	FBN2_uc003kuv.2_Missense_Mutation_p.G449E	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	482					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)														---	---	---	---
IL3	3562	broad.mit.edu	37	5	131398351	131398351	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:131398351T>C	uc003kwe.1	+							NM_000588	NP_000579			interleukin 3 precursor						cell-cell signaling|immune response|nervous system development|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of survival gene product expression|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|growth factor activity|interleukin-3 receptor binding			ovary(2)|central_nervous_system(1)	3		all_cancers(142;7.42e-12)|Lung NSC(810;4.25e-07)|all_lung(232;1.93e-06)|Prostate(281;0.00741)|Breast(839;0.0544)|Lung SC(612;0.122)|Ovarian(839;0.223)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.0161)|Lung(113;0.105)	Amlexanox(DB01025)											OREG0016762	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SLC22A5	6584	broad.mit.edu	37	5	131726528	131726528	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:131726528G>A	uc003kww.3	+	7	1463	c.1199G>A	c.(1198-1200)CGC>CAC	p.R400H	SLC22A5_uc003kwx.3_Missense_Mutation_p.R424H|SLC22A5_uc010jdr.1_Missense_Mutation_p.R20H	NM_003060	NP_003051	O76082	S22A5_HUMAN	solute carrier family 22 member 5	400	Cytoplasmic (Potential).				positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity				0		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)													---	---	---	---
PHF15	23338	broad.mit.edu	37	5	133914938	133914938	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:133914938T>C	uc003kzo.1	+	11	2483	c.2304T>C	c.(2302-2304)GGT>GGC	p.G768G	PHF15_uc011cxt.1_Silent_p.G812G|PHF15_uc003kzk.2_Silent_p.G828G|PHF15_uc003kzm.2_Silent_p.G769G|PHF15_uc003kzn.2_3'UTR	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	768					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
PITX1	5307	broad.mit.edu	37	5	134364597	134364597	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134364597C>T	uc010jea.2	-	3	1210	c.817G>A	c.(817-819)GTC>ATC	p.V273I	PITX1_uc011cxy.1_Missense_Mutation_p.V273I	NM_002653	NP_002644	P78337	PITX1_HUMAN	paired-like homeodomain transcription factor 1	273	Interacts with PIT-1 (By similarity).					nucleolus	sequence-specific DNA binding	p.V273I(1)		ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)														---	---	---	---
FBXL21	26223	broad.mit.edu	37	5	135272337	135272337	+	Silent	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:135272337A>C	uc010jec.1	+	1	75	c.54A>C	c.(52-54)GCA>GCC	p.A18A	FBXL21_uc003lbc.2_Intron	NM_012159	NP_036291	Q9UKT6	FXL21_HUMAN	F-box and leucine-rich repeat protein 21	18					rhythmic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
KDM3B	51780	broad.mit.edu	37	5	137715371	137715371	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137715371C>T	uc003lcy.1	+	5	879	c.679C>T	c.(679-681)CGT>TGT	p.R227C	KDM3B_uc010jew.1_5'UTR	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	227					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11																		---	---	---	---
PSD2	84249	broad.mit.edu	37	5	139193918	139193918	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:139193918C>T	uc003leu.1	+	4	1190	c.985C>T	c.(985-987)CGC>TGC	p.R329C		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	329	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
C5orf53	492311	broad.mit.edu	37	5	139508231	139508231	+	3'UTR	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:139508231C>T	uc003lfb.1	+	1						NM_001007189	NP_001007190			IgA-inducing protein precursor							extracellular region					0																		---	---	---	---
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139884482	139884482	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:139884482G>A	uc003lfs.1	+	16	3205	c.3081G>A	c.(3079-3081)TCG>TCA	p.S1027S	ANKHD1_uc003lfq.1_Silent_p.S1046S|ANKHD1_uc003lfr.2_Silent_p.S1027S|ANKHD1_uc003lft.1_Silent_p.S238S|ANKHD1_uc003lfu.1_Silent_p.S507S|ANKHD1_uc003lfv.1_Silent_p.S104S	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1027						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
CD14	929	broad.mit.edu	37	5	140011637	140011637	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140011637C>A	uc003lgi.1	-	2	1286	c.932G>T	c.(931-933)AGG>ATG	p.R311M	CD14_uc003lgj.1_Missense_Mutation_p.R311M	NM_000591	NP_000582	P08571	CD14_HUMAN	CD14 antigen precursor	311	LRR 10.				apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA4	56144	broad.mit.edu	37	5	140186806	140186806	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140186806C>T	uc003lhi.2	+	1	135	c.34C>T	c.(34-36)CGG>TGG	p.R12W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.R12W|PCDHA4_uc011daa.1_Missense_Mutation_p.R12W	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	12					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA4	56144	broad.mit.edu	37	5	140188497	140188497	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140188497C>T	uc003lhi.2	+	1	1826	c.1725C>T	c.(1723-1725)GGC>GGT	p.G575G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.G575G|PCDHA4_uc011daa.1_Silent_p.G575G	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	575	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA6	56142	broad.mit.edu	37	5	140207942	140207942	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140207942G>A	uc003lho.2	+	1	293	c.266G>A	c.(265-267)CGG>CAG	p.R89Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.R89Q|PCDHA6_uc011dab.1_Missense_Mutation_p.R89Q	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	89	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA6	56142	broad.mit.edu	37	5	140208825	140208825	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140208825G>A	uc003lho.2	+	1	1176	c.1149G>A	c.(1147-1149)GGG>GGA	p.G383G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.G383G|PCDHA6_uc011dab.1_Silent_p.G383G	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	383	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA7	56141	broad.mit.edu	37	5	140215089	140215089	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140215089T>C	uc003lhq.2	+	1	1121	c.1121T>C	c.(1120-1122)GTG>GCG	p.V374A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.V374A	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	374	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA11	56138	broad.mit.edu	37	5	140248987	140248987	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140248987C>T	uc003lia.2	+	1	1157	c.299C>T	c.(298-300)GCG>GTG	p.A100V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.A100V	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	100	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA11	56138	broad.mit.edu	37	5	140249919	140249919	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140249919G>A	uc003lia.2	+	1	2089	c.1231G>A	c.(1231-1233)GCC>ACC	p.A411T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.A411T	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	411	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHAC1	56135	broad.mit.edu	37	5	140306856	140306856	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140306856G>A	uc003lih.2	+	1	555	c.379G>A	c.(379-381)GGC>AGC	p.G127S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.G127S	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	127	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHAC2	56134	broad.mit.edu	37	5	140347356	140347356	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140347356G>A	uc003lii.2	+	1	1245	c.1005G>A	c.(1003-1005)GTG>GTA	p.V335V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Silent_p.V335V	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	335	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHB5	26167	broad.mit.edu	37	5	140517107	140517107	+	Silent	SNP	G	A	A	rs61745780		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140517107G>A	uc003liq.2	+	1	2308	c.2091G>A	c.(2089-2091)TCG>TCA	p.S697S		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	697	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB6	56130	broad.mit.edu	37	5	140531423	140531423	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140531423G>A	uc003lir.2	+	1	1585	c.1585G>A	c.(1585-1587)GTG>ATG	p.V529M	PCDHB6_uc011dah.1_Missense_Mutation_p.V393M	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	529	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB6	56130	broad.mit.edu	37	5	140531506	140531506	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140531506G>A	uc003lir.2	+	1	1668	c.1668G>A	c.(1666-1668)TCG>TCA	p.S556S	PCDHB6_uc011dah.1_Silent_p.S420S	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	556	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB8	56128	broad.mit.edu	37	5	140559225	140559225	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140559225G>A	uc011dai.1	+	1	1796	c.1610G>A	c.(1609-1611)CGC>CAC	p.R537H	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	537	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB12	56124	broad.mit.edu	37	5	140589745	140589745	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140589745C>T	uc003liz.2	+	1	1455	c.1266C>T	c.(1264-1266)ACC>ACT	p.T422T	PCDHB12_uc011dak.1_Silent_p.T85T	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	422	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB14	56122	broad.mit.edu	37	5	140605165	140605165	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140605165G>A	uc003ljb.2	+	1	2088	c.2088G>A	c.(2086-2088)TCG>TCA	p.S696S	PCDHB14_uc011dal.1_Silent_p.S543S	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	696	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHGB2	56103	broad.mit.edu	37	5	140740782	140740782	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140740782G>A	uc003ljs.1	+	1	1080	c.1080G>A	c.(1078-1080)TCG>TCA	p.S360S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Silent_p.S360S	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	360	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGB7	56099	broad.mit.edu	37	5	140798770	140798770	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140798770C>T	uc003lkn.1	+	1	1489	c.1344C>T	c.(1342-1344)AAC>AAT	p.N448N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Silent_p.N448N|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	448	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
HDAC3	8841	broad.mit.edu	37	5	141014481	141014481	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141014481G>A	uc003llf.2	-	3	244	c.178C>T	c.(178-180)CGC>TGC	p.R60C	HDAC3_uc003lle.1_Missense_Mutation_p.R3C|HDAC3_uc010jgd.1_Intron|HDAC3_uc010jge.1_Intron|RELL2_uc003lli.2_5'Flank|RELL2_uc003llh.2_5'Flank|RELL2_uc003llg.2_5'Flank|RELL2_uc010jgf.2_5'Flank	NM_003883	NP_003874	O15379	HDAC3_HUMAN	histone deacetylase 3	60	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)													---	---	---	---
ARAP3	64411	broad.mit.edu	37	5	141051787	141051787	+	Silent	SNP	G	A	A	rs149846650	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141051787G>A	uc003llm.2	-	10	1545	c.1467C>T	c.(1465-1467)TAC>TAT	p.Y489Y	ARAP3_uc011dbe.1_Silent_p.Y151Y|ARAP3_uc003lln.2_Silent_p.Y411Y|ARAP3_uc003llo.1_Silent_p.Y489Y	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	489	Arf-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7																		---	---	---	---
SPRY4	81848	broad.mit.edu	37	5	141694062	141694062	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141694062C>A	uc003lml.2	-	2	871	c.612G>T	c.(610-612)CAG>CAT	p.Q204H	SPRY4_uc010jgi.1_Missense_Mutation_p.Q227H	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	204	Cys-rich.|SPR.				multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)											Testicular_Cancer_Familial_Clustering_of				---	---	---	---
DPYSL3	1809	broad.mit.edu	37	5	146781177	146781177	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:146781177C>T	uc003lon.1	-	9	1004	c.894G>A	c.(892-894)GCG>GCA	p.A298A	DPYSL3_uc003loo.2_Silent_p.A412A	NM_001387	NP_001378	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	298					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
FBXO38	81545	broad.mit.edu	37	5	147805103	147805103	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147805103G>A	uc003lpf.1	+	14	1877	c.1757G>A	c.(1756-1758)CGT>CAT	p.R586H	FBXO38_uc003lpg.1_Missense_Mutation_p.R586H|FBXO38_uc003lph.2_Missense_Mutation_p.R586H	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	586						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
SH3TC2	79628	broad.mit.edu	37	5	148406585	148406585	+	Nonsense_Mutation	SNP	G	A	A	rs80338931	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148406585G>A	uc003lpu.2	-	11	2862	c.2710C>T	c.(2710-2712)CGA>TGA	p.R904*	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Nonsense_Mutation_p.R548*|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Nonsense_Mutation_p.R451*|SH3TC2_uc010jgx.2_Nonsense_Mutation_p.R897*|SH3TC2_uc003lpv.1_Nonsense_Mutation_p.R451*|SH3TC2_uc011dbz.1_Nonsense_Mutation_p.R789*	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	904							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
ARHGEF37	389337	broad.mit.edu	37	5	149006814	149006814	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149006814G>A	uc003lra.1	+	11	1704	c.1640G>A	c.(1639-1641)CGC>CAC	p.R547H		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	547	SH3 1.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0																		---	---	---	---
CSF1R	1436	broad.mit.edu	37	5	149453020	149453020	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149453020A>G	uc003lrl.2	-	6	1121	c.926T>C	c.(925-927)CTC>CCC	p.L309P	CSF1R_uc011dcd.1_Missense_Mutation_p.L161P|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.L309P|CSF1R_uc011dce.1_Intron	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	309	Extracellular (Potential).|Ig-like C2-type 4.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)													---	---	---	---
ARSI	340075	broad.mit.edu	37	5	149677808	149677808	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149677808G>A	uc003lrv.2	-	2	1268	c.679C>T	c.(679-681)CGT>TGT	p.R227C		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	227						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
GRIA1	2890	broad.mit.edu	37	5	152873596	152873596	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:152873596T>C	uc003lva.3	+	2	556	c.191T>C	c.(190-192)ATC>ACC	p.I64T	GRIA1_uc003luy.3_Missense_Mutation_p.I64T|GRIA1_uc003luz.3_5'UTR|GRIA1_uc011dcv.1_Intron|GRIA1_uc011dcw.1_Missense_Mutation_p.I64T|GRIA1_uc011dcx.1_5'UTR|GRIA1_uc011dcy.1_Missense_Mutation_p.I74T|GRIA1_uc011dcz.1_Missense_Mutation_p.I74T|GRIA1_uc010jia.1_Missense_Mutation_p.I44T	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	64	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)													---	---	---	---
GRIA1	2890	broad.mit.edu	37	5	153085355	153085355	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:153085355G>A	uc003lva.3	+	11	1916	c.1551G>A	c.(1549-1551)ATG>ATA	p.M517I	GRIA1_uc003luy.3_Missense_Mutation_p.M517I|GRIA1_uc003luz.3_Missense_Mutation_p.M422I|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.M437I|GRIA1_uc011dcx.1_Missense_Mutation_p.M448I|GRIA1_uc011dcy.1_Missense_Mutation_p.M527I|GRIA1_uc011dcz.1_Missense_Mutation_p.M527I|GRIA1_uc010jia.1_Missense_Mutation_p.M497I	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	517	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)													---	---	---	---
GRIA1	2890	broad.mit.edu	37	5	153144175	153144175	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:153144175A>G	uc003lva.3	+	12	2370	c.2005A>G	c.(2005-2007)ACT>GCT	p.T669A	GRIA1_uc003luy.3_Missense_Mutation_p.T669A|GRIA1_uc003luz.3_Missense_Mutation_p.T574A|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.T589A|GRIA1_uc011dcx.1_Missense_Mutation_p.T600A|GRIA1_uc011dcy.1_Missense_Mutation_p.T679A|GRIA1_uc011dcz.1_Missense_Mutation_p.T679A	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	669	Glutamate binding (By similarity).|Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)													---	---	---	---
KIF4B	285643	broad.mit.edu	37	5	154396385	154396385	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154396385T>C	uc010jih.1	+	1	3126	c.2966T>C	c.(2965-2967)ATC>ACC	p.I989T		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	989	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
CLINT1	9685	broad.mit.edu	37	5	157214796	157214796	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:157214796A>G	uc003lxj.1	-	12	1926	c.1736T>C	c.(1735-1737)ATG>ACG	p.M579T	CLINT1_uc003lxg.1_Missense_Mutation_p.M116T|CLINT1_uc003lxh.1_Missense_Mutation_p.M153T|CLINT1_uc003lxi.1_Missense_Mutation_p.M579T|CLINT1_uc011ddv.1_Missense_Mutation_p.M597T	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	579	Met-rich.				endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)															---	---	---	---
ODZ2	57451	broad.mit.edu	37	5	167674458	167674458	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167674458A>G	uc010jjd.2	+	27	6487	c.6487A>G	c.(6487-6489)ATG>GTG	p.M2163V	ODZ2_uc003lzr.3_Missense_Mutation_p.M1933V|ODZ2_uc003lzt.3_Missense_Mutation_p.M1536V|ODZ2_uc010jje.2_Missense_Mutation_p.M1427V	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)														---	---	---	---
RANBP17	64901	broad.mit.edu	37	5	170632540	170632540	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:170632540G>A	uc003mba.2	+	20	2171	c.2155G>A	c.(2155-2157)GGG>AGG	p.G719R	RANBP17_uc003mbb.2_Missense_Mutation_p.G44R|RANBP17_uc003mbd.2_Missense_Mutation_p.G82R|RANBP17_uc010jjs.2_RNA|RANBP17_uc003mbc.2_Missense_Mutation_p.G82R	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	719					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)					T	TRD@	ALL								---	---	---	---
BOD1	91272	broad.mit.edu	37	5	173036230	173036230	+	Intron	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:173036230G>T	uc003mcq.2	-						BOD1_uc003mcr.2_Intron	NM_138369	NP_612378			biorientation of chromosomes in cell division 1						cell division|mitosis	condensed chromosome kinetochore|microtubule organizing center				ovary(2)	2																		---	---	---	---
UNC5A	90249	broad.mit.edu	37	5	176295907	176295907	+	Silent	SNP	C	T	T	rs144713374		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176295907C>T	uc003mey.2	+	5	855	c.663C>T	c.(661-663)TGC>TGT	p.C221C	UNC5A_uc003mex.1_Silent_p.C221C|UNC5A_uc010jkg.1_Silent_p.C181C	NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	221	Ig-like C2-type.|Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
N4BP3	23138	broad.mit.edu	37	5	177548793	177548793	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:177548793C>T	uc003mik.1	+	5	1673	c.1426C>T	c.(1426-1428)CGA>TGA	p.R476*	N4BP3_uc003mil.1_Nonsense_Mutation_p.R145*	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	476	Potential.					cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
GRM6	2916	broad.mit.edu	37	5	178408747	178408747	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178408747G>A	uc003mjr.2	-	10	2724	c.2545C>T	c.(2545-2547)CAG>TAG	p.Q849*	GRM6_uc003mjq.2_Nonsense_Mutation_p.Q252*	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	849	Cytoplasmic (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)														---	---	---	---
ADAMTS2	9509	broad.mit.edu	37	5	178566909	178566909	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178566909C>T	uc003mjw.2	-	11	1757	c.1757G>A	c.(1756-1758)CGC>CAC	p.R586H		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	586	TSP type-1 1.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)														---	---	---	---
MAML1	9794	broad.mit.edu	37	5	179201712	179201712	+	Missense_Mutation	SNP	C	A	A	rs142452741		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179201712C>A	uc003mkm.2	+	5	3148	c.2885C>A	c.(2884-2886)CCT>CAT	p.P962H	MAML1_uc003mkn.1_Intron	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	962					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
TBC1D9B	23061	broad.mit.edu	37	5	179301892	179301892	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179301892G>A	uc003mlh.2	-						TBC1D9B_uc003mli.2_Intron|TBC1D9B_uc003mlj.2_Intron|TBC1D9B_uc011dgv.1_5'Flank	NM_198868	NP_942568			TBC1 domain family, member 9B (with GRAM domain)							integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
CNOT6	57472	broad.mit.edu	37	5	179991555	179991555	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179991555A>G	uc003mlx.2	+	5	801	c.452A>G	c.(451-453)AAC>AGC	p.N151S	CNOT6_uc010jld.2_Missense_Mutation_p.N151S|CNOT6_uc010jle.2_Missense_Mutation_p.N151S	NM_015455	NP_056270	Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	151					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding				0	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)														---	---	---	---
EXOC2	55770	broad.mit.edu	37	6	599181	599181	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:599181G>A	uc003mtd.2	-	8	921	c.787C>T	c.(787-789)CGG>TGG	p.R263W	EXOC2_uc003mte.2_Missense_Mutation_p.R263W|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	263					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)														---	---	---	---
PRPF4B	8899	broad.mit.edu	37	6	4037685	4037685	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:4037685C>T	uc003mvv.2	+	3	1384	c.1293C>T	c.(1291-1293)AGC>AGT	p.S431S	PRPF4B_uc003mvw.2_RNA|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	431	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)																---	---	---	---
PECI	10455	broad.mit.edu	37	6	4117629	4117629	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:4117629T>C	uc003mwf.2	-	9	979	c.942A>G	c.(940-942)CAA>CAG	p.Q314Q	C6orf201_uc003mwa.3_Intron|C6orf201_uc003mvz.3_Intron|C6orf201_uc011dhw.1_Intron|C6orf201_uc003mwb.3_Intron|PECI_uc003mwc.2_Silent_p.Q147Q|PECI_uc003mwd.2_Silent_p.Q284Q|PECI_uc003mwe.2_Silent_p.Q161Q|PECI_uc010jnr.1_RNA	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	314	ECH-like.				fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)																---	---	---	---
CDYL	9425	broad.mit.edu	37	6	4892486	4892486	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:4892486A>G	uc003mwi.2	+	4	857	c.726A>G	c.(724-726)GGA>GGG	p.G242G	CDYL_uc003mwj.2_Silent_p.G188G|CDYL_uc003mwk.2_Intron|CDYL_uc011dhx.1_Silent_p.G56G|CDYL_uc011dhy.1_Silent_p.G56G	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	242					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)														---	---	---	---
MAK	4117	broad.mit.edu	37	6	10796519	10796519	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:10796519T>G	uc003mzl.2	-	8	1084	c.855A>C	c.(853-855)CAA>CAC	p.Q285H	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_Intron|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Missense_Mutation_p.Q285H|MAK_uc010jov.1_RNA	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	285					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)																---	---	---	---
SIRT5	23408	broad.mit.edu	37	6	13584404	13584404	+	Missense_Mutation	SNP	C	A	A	rs113600137		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13584404C>A	uc003nay.2	+	3	358	c.62C>A	c.(61-63)CCT>CAT	p.P21H	SIRT5_uc003naw.2_Missense_Mutation_p.P21H|SIRT5_uc003nax.2_5'UTR|SIRT5_uc011dit.1_Missense_Mutation_p.P21H	NM_012241	NP_036373	Q9NXA8	SIRT5_HUMAN	sirtuin 5 isoform 1	21					chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)													---	---	---	---
JARID2	3720	broad.mit.edu	37	6	15496926	15496926	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:15496926G>A	uc003nbj.2	+	7	1714	c.1470G>A	c.(1468-1470)CCG>CCA	p.P490P	JARID2_uc011diu.1_Silent_p.P354P|JARID2_uc011div.1_Silent_p.P318P|JARID2_uc011diw.1_Silent_p.P452P	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	490					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)																---	---	---	---
LRRC16A	55604	broad.mit.edu	37	6	25515955	25515955	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:25515955T>C	uc011djw.1	+	21	2061	c.1685T>C	c.(1684-1686)ATC>ACC	p.I562T	LRRC16A_uc010jpx.2_Missense_Mutation_p.I562T|LRRC16A_uc010jpy.2_Missense_Mutation_p.I562T	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	562	LRR 8.				actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
SLC17A2	10246	broad.mit.edu	37	6	25921412	25921412	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:25921412C>T	uc011dkb.1	-	3	552	c.469G>A	c.(469-471)GCC>ACC	p.A157T	SLC17A2_uc011dkc.1_Missense_Mutation_p.A157T|SLC17A2_uc003nfl.2_Missense_Mutation_p.A157T			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	157					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1																		---	---	---	---
BTN3A3	10384	broad.mit.edu	37	6	26452153	26452153	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26452153C>T	uc003nhz.2	+	11	1449	c.1269C>T	c.(1267-1269)GTC>GTT	p.V423V	BTN3A3_uc003nia.2_Silent_p.V381V|BTN3A3_uc011dkn.1_Silent_p.V374V	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	423	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane					0																		---	---	---	---
SCAND3	114821	broad.mit.edu	37	6	28547153	28547153	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28547153A>G	uc003nlo.2	-	2	1082	c.464T>C	c.(463-465)ATG>ACG	p.M155T		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	155					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
ZNF311	282890	broad.mit.edu	37	6	28964030	28964030	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28964030G>A	uc003nlu.2	-	7	1262	c.749C>T	c.(748-750)GCC>GTC	p.A250V	ZNF311_uc011dlk.1_Missense_Mutation_p.A158V|ZNF311_uc003nlv.2_Missense_Mutation_p.A158V	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	250	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0																		---	---	---	---
TRIM26	7726	broad.mit.edu	37	6	30166679	30166679	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30166679C>T	uc003npr.2	-	3	411	c.202G>A	c.(202-204)GTG>ATG	p.V68M	TRIM26_uc003nps.2_Missense_Mutation_p.V68M|TRIM26_uc010jry.2_Translation_Start_Site|TRIM26_uc003npt.2_Missense_Mutation_p.V68M|TRIM26_uc003npu.1_Missense_Mutation_p.V68M	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	68							DNA binding|zinc ion binding			ovary(2)|lung(1)	3																		---	---	---	---
PPP1R10	5514	broad.mit.edu	37	6	30571948	30571948	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30571948G>A	uc003nqn.1	-	14	1897	c.1345C>T	c.(1345-1347)CGT>TGT	p.R449C	PPP1R10_uc010jsc.1_Missense_Mutation_p.R103C	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	449	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4																		---	---	---	---
MDC1	9656	broad.mit.edu	37	6	30673671	30673671	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30673671C>A	uc003nrg.3	-	10	3729	c.3289G>T	c.(3289-3291)GAG>TAG	p.E1097*	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Nonsense_Mutation_p.E704*	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1097	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4													Other_conserved_DNA_damage_response_genes					---	---	---	---
POU5F1	5460	broad.mit.edu	37	6	31133735	31133735	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31133735G>A	uc003nsv.2	-	2	549	c.495C>T	c.(493-495)GCC>GCT	p.A165A	POU5F1_uc003nsu.2_Silent_p.A70A|uc011dnf.1_RNA	NM_002701	NP_002692	Q01860	PO5F1_HUMAN	POU domain, class 5, transcription factor 1	165	POU-specific.				anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	skin(7)|salivary_gland(2)|bone(2)|lung(1)|ovary(1)	13								T	EWSR1	sarcoma								---	---	---	---
HLA-B	3106	broad.mit.edu	37	6	31322412	31322412	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31322412G>A	uc003nth.2	-	6	1097	c.1043C>T	c.(1042-1044)GCG>GTG	p.A348V	HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Missense_Mutation_p.A227V|HLA-B_uc003nti.1_RNA	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	348	Cytoplasmic (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0														Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				---	---	---	---
AIF1	199	broad.mit.edu	37	6	31583458	31583458	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31583458C>T	uc003nuy.2	+	3	173	c.99C>T	c.(97-99)GAC>GAT	p.D33D	AIF1_uc010jsy.2_Translation_Start_Site|AIF1_uc003nva.2_5'Flank	NM_001623	NP_001614	P55008	AIF1_HUMAN	allograft inflammatory factor 1 isoform 3	33				D -> H (in Ref. 2; AAA92457).	actin filament bundle assembly|cell cycle arrest|inflammatory response|negative regulation of cell proliferation	nucleus|ruffle membrane	actin filament binding|calcium ion binding			ovary(1)	1																		---	---	---	---
C2	717	broad.mit.edu	37	6	31868916	31868916	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31868916G>T	uc011dop.1	+	1	141	c.73G>T	c.(73-75)GCT>TCT	p.A25S	C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|ZBTB12_uc003nyd.1_Missense_Mutation_p.P56H	NM_001145903	NP_001139375	P06681	CO2_HUMAN	complement component 2 isoform 2 preproprotein	148					complement activation, classical pathway|innate immune response|proteolysis	extracellular space	serine-type endopeptidase activity			ovary(1)|skin(1)	2		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)														---	---	---	---
TNXB	7148	broad.mit.edu	37	6	32011609	32011609	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32011609A>T	uc003nzl.2	-	35	11643	c.11441T>A	c.(11440-11442)ATC>AAC	p.I3814N	TNXB_uc003nzg.1_Missense_Mutation_p.I245N|TNXB_uc003nzh.1_Missense_Mutation_p.I283N	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3861	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0																		---	---	---	---
PRRT1	80863	broad.mit.edu	37	6	32117369	32117369	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32117369G>A	uc003nzt.2	-	3	805	c.689C>T	c.(688-690)ACC>ATC	p.T230I	PRRT1_uc003nzs.2_Missense_Mutation_p.T271I|PRRT1_uc003nzu.2_Silent_p.D122D	NM_030651	NP_085154	Q99946	PRRT1_HUMAN	NG5 protein	230	Helical; (Potential).				response to biotic stimulus	integral to membrane				breast(1)	1																		---	---	---	---
EGFL8	80864	broad.mit.edu	37	6	32134513	32134513	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32134513G>A	uc003oab.1	+	4	318	c.260G>A	c.(259-261)CGG>CAG	p.R87Q	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Missense_Mutation_p.R87Q	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	87	EMI.					extracellular region|integral to membrane	calcium ion binding				0																		---	---	---	---
C6orf227	401253	broad.mit.edu	37	6	33561013	33561013	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33561013A>G	uc003oew.1	-	1	103	c.101T>C	c.(100-102)CTG>CCG	p.L34P		NR_027908				RecName: Full=Putative uncharacterized protein C6orf227;												0																		---	---	---	---
ITPR3	3710	broad.mit.edu	37	6	33623676	33623676	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33623676T>C	uc011drk.1	+							NM_002224	NP_002215			inositol 1,4,5-triphosphate receptor, type 3						activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19																		---	---	---	---
IP6K3	117283	broad.mit.edu	37	6	33693227	33693227	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33693227G>A	uc010jvf.2	-	6	1292	c.756C>T	c.(754-756)TGC>TGT	p.C252C	IP6K3_uc003ofb.2_Silent_p.C252C	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	252					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0																		---	---	---	---
IP6K3	117283	broad.mit.edu	37	6	33703227	33703227	+	Silent	SNP	G	A	A	rs150212654		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33703227G>A	uc010jvf.2	-	3	563	c.27C>T	c.(25-27)GCC>GCT	p.A9A	IP6K3_uc003ofb.2_Silent_p.A9A	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	9					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0																		---	---	---	---
LHFPL5	222662	broad.mit.edu	37	6	35773664	35773664	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35773664C>A	uc003olg.1	+	1	594	c.217C>A	c.(217-219)CTG>ATG	p.L73M		NM_182548	NP_872354	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	73	Helical; (Potential).					integral to membrane				skin(1)	1																		---	---	---	---
MAPK14	1432	broad.mit.edu	37	6	36027133	36027133	+	Intron	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36027133A>T	uc003olp.2	+						MAPK14_uc011dth.1_Intron|MAPK14_uc003olo.2_Intron|MAPK14_uc003olq.2_Intron|MAPK14_uc003olr.2_Intron|MAPK14_uc011dti.1_Intron	NM_001315	NP_001306			mitogen-activated protein kinase 14 isoform 1						activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
ZFAND3	60685	broad.mit.edu	37	6	38120049	38120049	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38120049C>T	uc003onx.2	+	6	983	c.568C>T	c.(568-570)CAC>TAC	p.H190Y		NM_021943	NP_068762	Q9H8U3	ZFAN3_HUMAN	zinc finger, AN1-type domain 3	190	AN1-type.						DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38690893	38690893	+	5'UTR	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38690893T>C	uc003ooe.1	+	1					DNAH8_uc003ood.1_Missense_Mutation_p.L103S	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
KCNK5	8645	broad.mit.edu	37	6	39159505	39159505	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:39159505C>T	uc003oon.2	-	5	1025	c.661G>A	c.(661-663)GCC>ACC	p.A221T		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	221					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2																		---	---	---	---
KIF6	221458	broad.mit.edu	37	6	39693056	39693056	+	Silent	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:39693056T>G	uc003oot.2	-	1	126	c.31A>C	c.(31-33)AGG>CGG	p.R11R	KIF6_uc011dua.1_Silent_p.R11R|KIF6_uc010jxb.1_Silent_p.R11R	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	11	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3																		---	---	---	---
CUL7	9820	broad.mit.edu	37	6	43017887	43017887	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43017887G>A	uc003otq.2	-	6	1686	c.1383C>T	c.(1381-1383)GCC>GCT	p.A461A	CUL7_uc011dvb.1_Silent_p.A545A|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	461					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)															---	---	---	---
CUL9	23113	broad.mit.edu	37	6	43181612	43181612	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43181612G>A	uc003ouk.2	+	29	5725	c.5650G>A	c.(5650-5652)GGG>AGG	p.G1884R	CUL9_uc003oul.2_Missense_Mutation_p.G1856R|CUL9_uc010jyk.2_Missense_Mutation_p.G1036R|CUL9_uc003oun.2_5'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1884					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12																		---	---	---	---
RUNX2	860	broad.mit.edu	37	6	45390650	45390650	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:45390650C>A	uc011dvx.1	+	3	589	c.379C>A	c.(379-381)CCC>ACC	p.P127T	RUNX2_uc011dvy.1_Missense_Mutation_p.P127T|RUNX2_uc003oxt.2_Missense_Mutation_p.P113T	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	127	Runt.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3																		---	---	---	---
TFAP2D	83741	broad.mit.edu	37	6	50696582	50696582	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:50696582G>A	uc003paf.2	+	4	1124	c.612G>A	c.(610-612)GTG>GTA	p.V204V	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	204							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)																	---	---	---	---
DST	667	broad.mit.edu	37	6	56382399	56382399	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56382399G>A	uc003pdf.2	-	64	11820	c.11792C>T	c.(11791-11793)GCT>GTT	p.A3931V	DST_uc003pcz.3_Missense_Mutation_p.A3753V|DST_uc011dxj.1_Missense_Mutation_p.A3782V|DST_uc011dxk.1_Missense_Mutation_p.A3793V|DST_uc003pcy.3_Missense_Mutation_p.A3427V	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5839	Spectrin 10.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
DST	667	broad.mit.edu	37	6	56480956	56480956	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56480956G>A	uc003pdf.2	-						DST_uc003pcz.3_Intron|DST_uc011dxj.1_Intron|DST_uc011dxk.1_Intron|DST_uc003pcy.3_Intron|DST_uc003pdb.2_Intron|DST_uc003pdc.3_Missense_Mutation_p.R2437W	NM_001144769	NP_001138241			dystonin isoform 2						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
KHDRBS2	202559	broad.mit.edu	37	6	62887178	62887178	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:62887178T>A	uc003peg.2	-	2	378	c.131A>T	c.(130-132)GAC>GTC	p.D44V		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	44					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)														---	---	---	---
EYS	346007	broad.mit.edu	37	6	66200483	66200483	+	Intron	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:66200483T>A	uc011dxu.1	-						EYS_uc003peq.2_Intron|EYS_uc003per.1_Intron	NM_001142800	NP_001136272			eyes shut homolog isoform 1						response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6																		---	---	---	---
COL9A1	1297	broad.mit.edu	37	6	70992675	70992675	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70992675G>A	uc003pfg.3	-						COL9A1_uc003pfe.3_5'Flank|COL9A1_uc003pff.3_Intron	NM_001851	NP_001842			alpha 1 type IX collagen isoform 1 precursor						axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4																		---	---	---	---
COL9A1	1297	broad.mit.edu	37	6	71004218	71004218	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:71004218C>T	uc003pfg.3	-	5	507	c.348G>A	c.(346-348)ACG>ACA	p.T116T		NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	116	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4																		---	---	---	---
RNGTT	8732	broad.mit.edu	37	6	89614482	89614482	+	Silent	SNP	G	A	A	rs144619191	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:89614482G>A	uc003pmr.2	-	6	856	c.636C>T	c.(634-636)CCC>CCT	p.P212P	RNGTT_uc003pms.2_Silent_p.P212P|RNGTT_uc011dzu.1_Silent_p.P152P|RNGTT_uc003pmt.2_Silent_p.P212P	NM_003800	NP_003791	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	212	TPase.			P -> T (in Ref. 6; AAH19954).	interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)														---	---	---	---
BACH2	60468	broad.mit.edu	37	6	90661494	90661494	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90661494G>A	uc011eab.1	-	7	1140	c.331C>T	c.(331-333)CGC>TGC	p.R111C	BACH2_uc003pnw.2_Missense_Mutation_p.R111C|BACH2_uc010kch.2_Missense_Mutation_p.R111C	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	111						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)														---	---	---	---
SIM1	6492	broad.mit.edu	37	6	100838484	100838484	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:100838484T>C	uc003pqj.3	-	11	2261	c.2054A>G	c.(2053-2055)CAT>CGT	p.H685R	SIM1_uc010kcu.2_Missense_Mutation_p.H685R	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	685	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)														---	---	---	---
ASCC3	10973	broad.mit.edu	37	6	101109676	101109676	+	Intron	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:101109676T>A	uc003pqk.2	-						ASCC3_uc011eai.1_Intron	NM_006828	NP_006819			activating signal cointegrator 1 complex subunit						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)														---	---	---	---
GRIK2	2898	broad.mit.edu	37	6	101847142	101847142	+	5'UTR	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:101847142C>T	uc003pqp.3	+	1					GRIK2_uc003pqn.2_5'UTR|GRIK2_uc003pqo.3_5'UTR|GRIK2_uc010kcw.2_5'UTR	NM_021956	NP_068775			glutamate receptor, ionotropic, kainate 2						glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)													---	---	---	---
HACE1	57531	broad.mit.edu	37	6	105198303	105198303	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:105198303G>T	uc003pqu.1	-	20	2533	c.2256C>A	c.(2254-2256)GCC>GCA	p.A752A	HACE1_uc010kcy.1_Silent_p.A234A|HACE1_uc010kcz.1_Silent_p.A537A|HACE1_uc010kcx.1_Silent_p.A161A|HACE1_uc003pqt.1_Silent_p.A405A	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	752	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)														---	---	---	---
SEC63	11231	broad.mit.edu	37	6	108222672	108222672	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:108222672C>T	uc003psc.3	-	13	1528	c.1259G>A	c.(1258-1260)CGT>CAT	p.R420H	SEC63_uc003psb.3_Missense_Mutation_p.R280H	NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	420	SEC63 1.|Cytoplasmic (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)														---	---	---	---
FOXO3	2309	broad.mit.edu	37	6	108985139	108985139	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:108985139G>A	uc003psk.2	+	3	1419	c.1103G>A	c.(1102-1104)CGG>CAG	p.R368Q	FOXO3_uc003psn.2_Intron|FOXO3_uc003psm.2_Missense_Mutation_p.R368Q|FOXO3_uc011ean.1_Missense_Mutation_p.R148Q|FOXO3_uc010kdj.1_Missense_Mutation_p.R148Q	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	368					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)														---	---	---	---
ARMC2	84071	broad.mit.edu	37	6	109294701	109294701	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109294701C>A	uc003pss.3	+	18	2762	c.2588C>A	c.(2587-2589)CCC>CAC	p.P863H	ARMC2_uc011eao.1_Missense_Mutation_p.P698H	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	863							binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)														---	---	---	---
GJA1	2697	broad.mit.edu	37	6	121768103	121768103	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:121768103T>C	uc003pyr.2	+	2	360	c.110T>C	c.(109-111)CTG>CCG	p.L37P	GJA1_uc011ebo.1_Intron|GJA1_uc011ebp.1_5'UTR	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	37	Extracellular (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)													---	---	---	---
PTPRK	5796	broad.mit.edu	37	6	128316642	128316642	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:128316642G>A	uc003qbk.2	-	18	3173	c.2806C>T	c.(2806-2808)CCT>TCT	p.P936S	PTPRK_uc003qbj.2_Missense_Mutation_p.P937S|PTPRK_uc010kfc.2_Missense_Mutation_p.P937S|PTPRK_uc011ebu.1_Missense_Mutation_p.P953S	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	936	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129419458	129419458	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129419458T>C	uc003qbn.2	+	4	642	c.537T>C	c.(535-537)CTT>CTC	p.L179L	LAMA2_uc003qbo.2_Silent_p.L179L	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	179	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129813110	129813110	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129813110A>G	uc003qbn.2	+	56	8068	c.7963A>G	c.(7963-7965)ATC>GTC	p.I2655V	LAMA2_uc003qbo.2_Missense_Mutation_p.I2651V|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2655	Laminin G-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
ENPP1	5167	broad.mit.edu	37	6	132193250	132193250	+	Intron	SNP	C	A	A	rs57367395		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:132193250C>A	uc011ecf.1	+						ENPP1_uc003qcy.2_Intron	NM_006208	NP_006199			ectonucleotide pyrophosphatase/phosphodiesterase						3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)													---	---	---	---
MAP3K5	4217	broad.mit.edu	37	6	136913687	136913687	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136913687A>G	uc003qhc.2	-	22	3305	c.2944T>C	c.(2944-2946)TAC>CAC	p.Y982H	MAP3K5_uc011edj.1_Missense_Mutation_p.Y229H|MAP3K5_uc011edk.1_Missense_Mutation_p.Y828H	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	982					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)														---	---	---	---
IL20RA	53832	broad.mit.edu	37	6	137329811	137329811	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:137329811G>A	uc003qhj.2	-	5	1082	c.649C>T	c.(649-651)CAC>TAC	p.H217Y	IL20RA_uc011edl.1_Missense_Mutation_p.H168Y|IL20RA_uc003qhk.2_Missense_Mutation_p.H106Y|IL20RA_uc003qhi.2_5'UTR	NM_014432	NP_055247	Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha precursor	217	Extracellular (Potential).|Fibronectin type-III 2.					integral to membrane	receptor activity			ovary(2)|skin(2)	4	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)														---	---	---	---
TNFAIP3	7128	broad.mit.edu	37	6	138201244	138201244	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:138201244C>T	uc003qhr.2	+	8	2009	c.1943C>T	c.(1942-1944)GCG>GTG	p.A648V	TNFAIP3_uc003qhs.2_Missense_Mutation_p.A648V	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	648	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)				D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								---	---	---	---
HECA	51696	broad.mit.edu	37	6	139487945	139487945	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:139487945G>A	uc003qin.2	+	2	1081	c.796G>A	c.(796-798)GGT>AGT	p.G266S		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	266					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)														---	---	---	---
FBXO30	84085	broad.mit.edu	37	6	146126057	146126057	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146126057C>T	uc003qla.2	-	2	1684	c.1485G>A	c.(1483-1485)CCG>CCA	p.P495P	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	495							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)														---	---	---	---
GRM1	2911	broad.mit.edu	37	6	146480484	146480484	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146480484G>T	uc010khw.1	+	3	1171	c.701G>T	c.(700-702)GGG>GTG	p.G234V	GRM1_uc010khu.1_Missense_Mutation_p.G234V|GRM1_uc010khv.1_Missense_Mutation_p.G234V|GRM1_uc003qll.2_Missense_Mutation_p.G234V|GRM1_uc011edz.1_Missense_Mutation_p.G234V|GRM1_uc011eea.1_Missense_Mutation_p.G234V	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	234	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)													---	---	---	---
PLEKHG1	57480	broad.mit.edu	37	6	151142322	151142322	+	Intron	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151142322G>C	uc003qny.1	+						PLEKHG1_uc011eel.1_Intron|PLEKHG1_uc011eem.1_Intron|PLEKHG1_uc003qnz.2_Intron	NM_001029884	NP_001025055			pleckstrin homology domain containing, family G						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)														---	---	---	---
C6orf97	80129	broad.mit.edu	37	6	151857487	151857487	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151857487C>T	uc003qol.2	+	2	181	c.92C>T	c.(91-93)ACG>ATG	p.T31M		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	31	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)														---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152466625	152466625	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152466625A>G	uc010kiw.2	-						SYNE1_uc010kiv.2_Intron|SYNE1_uc003qos.3_Intron|SYNE1_uc003qot.3_Missense_Mutation_p.S8277P|SYNE1_uc003qou.3_Intron|SYNE1_uc003qop.3_Missense_Mutation_p.S510P|SYNE1_uc011eez.1_Intron|SYNE1_uc003qoq.3_Intron|SYNE1_uc003qor.3_Missense_Mutation_p.S1248P	NM_182961	NP_892006			spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152702327	152702327	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152702327C>A	uc010kiw.2	-	56	9425	c.8823G>T	c.(8821-8823)CAG>CAT	p.Q2941H	SYNE1_uc003qot.3_Missense_Mutation_p.Q2948H|SYNE1_uc003qou.3_Missense_Mutation_p.Q2941H|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_Missense_Mutation_p.Q19H|SYNE1_uc010kjb.1_Missense_Mutation_p.Q2924H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2941	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152776602	152776602	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152776602C>T	uc010kiw.2	-	24	3453	c.2851G>A	c.(2851-2853)GAG>AAG	p.E951K	SYNE1_uc003qot.3_Missense_Mutation_p.E958K|SYNE1_uc003qou.3_Missense_Mutation_p.E951K|SYNE1_uc010kjb.1_Missense_Mutation_p.E934K|SYNE1_uc003qow.2_Missense_Mutation_p.E246K|SYNE1_uc003qox.1_Missense_Mutation_p.E467K|SYNE1_uc003qoz.2_Missense_Mutation_p.E383K|SYNE1_uc003qoy.2_Missense_Mutation_p.E518K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	951	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
TIAM2	26230	broad.mit.edu	37	6	155577810	155577810	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155577810T>C	uc003qqb.2	+	29	5934	c.4661T>C	c.(4660-4662)TTG>TCG	p.L1554S	TIAM2_uc003qqe.2_Missense_Mutation_p.L1554S|TIAM2_uc010kjj.2_Missense_Mutation_p.L1116S|TIAM2_uc003qqf.2_Missense_Mutation_p.L930S|TIAM2_uc011efl.1_Missense_Mutation_p.L898S|TIAM2_uc003qqg.2_Missense_Mutation_p.L866S|TIAM2_uc003qqh.2_Missense_Mutation_p.L479S|uc003qqi.1_RNA	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1554					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)														---	---	---	---
TFB1M	51106	broad.mit.edu	37	6	155581523	155581523	+	Silent	SNP	G	A	A	rs149796947	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155581523G>A	uc003qqj.3	-	6	742	c.678C>T	c.(676-678)GGC>GGT	p.G226G	TFB1M_uc003qqk.2_Intron	NM_016020	NP_057104	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			skin(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)														---	---	---	---
ARID1B	57492	broad.mit.edu	37	6	157522620	157522620	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:157522620T>A	uc003qqn.2	+	18	4990	c.4838T>A	c.(4837-4839)ATC>AAC	p.I1613N	ARID1B_uc003qqo.2_Missense_Mutation_p.I1573N|ARID1B_uc003qqp.2_Missense_Mutation_p.I1560N	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1618					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)														---	---	---	---
SYNJ2	8871	broad.mit.edu	37	6	158499313	158499313	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158499313G>T	uc003qqx.1	+	18	2642	c.2567G>T	c.(2566-2568)AGA>ATA	p.R856I	SYNJ2_uc003qqw.1_Missense_Mutation_p.R856I|SYNJ2_uc003qqy.1_Missense_Mutation_p.R569I|SYNJ2_uc003qqz.1_Missense_Mutation_p.R473I|SYNJ2_uc003qra.1_Missense_Mutation_p.R199I	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	856	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)														---	---	---	---
SYNJ2	8871	broad.mit.edu	37	6	158509770	158509770	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158509770C>T	uc003qqx.1	+	24	3497	c.3422C>T	c.(3421-3423)ACG>ATG	p.T1141M	SYNJ2_uc003qqw.1_Missense_Mutation_p.T1141M|SYNJ2_uc003qqy.1_Missense_Mutation_p.T854M|SYNJ2_uc003qqz.1_Missense_Mutation_p.T758M|SYNJ2_uc003qra.1_Missense_Mutation_p.T484M|SYNJ2_uc010kjp.1_Missense_Mutation_p.T24M	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1141	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)														---	---	---	---
TULP4	56995	broad.mit.edu	37	6	158834150	158834150	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158834150G>A	uc003qrf.2	+	2	1663	c.306G>A	c.(304-306)GCG>GCA	p.A102A	TULP4_uc011efo.1_Silent_p.A102A|TULP4_uc003qrg.2_Silent_p.A102A	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	102	WD 1.				intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)														---	---	---	---
FNDC1	84624	broad.mit.edu	37	6	159654471	159654471	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:159654471C>T	uc010kjv.2	+	11	3127	c.2927C>T	c.(2926-2928)GCG>GTG	p.A976V	FNDC1_uc010kjw.1_Missense_Mutation_p.A861V	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	976						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)														---	---	---	---
SLC22A2	6582	broad.mit.edu	37	6	160662497	160662497	+	Intron	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160662497A>T	uc003qtf.2	-						SLC22A2_uc003qte.1_Intron	NM_003058	NP_003049			solute carrier family 22 member 2						body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)														---	---	---	---
PLG	5340	broad.mit.edu	37	6	161135861	161135861	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161135861G>T	uc003qtm.3	+	6	646	c.583G>T	c.(583-585)GGC>TGC	p.G195C		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	195	Kringle 2.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)													---	---	---	---
PLG	5340	broad.mit.edu	37	6	161139823	161139823	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161139823C>T	uc003qtm.3	+	9	1112	c.1049C>T	c.(1048-1050)CCG>CTG	p.P350L		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	350	Kringle 3.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)													---	---	---	---
CCR6	1235	broad.mit.edu	37	6	167549868	167549868	+	Silent	SNP	G	A	A	rs145186145		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:167549868G>A	uc003qvl.2	+	13	2626	c.150G>A	c.(148-150)CCG>CCA	p.P50P	CCR6_uc010kkm.2_Silent_p.P50P|CCR6_uc003qvn.3_Silent_p.P50P|CCR6_uc003qvm.3_Silent_p.P50P	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	50	Helical; Name=1; (Potential).				cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)														---	---	---	---
MLLT4	4301	broad.mit.edu	37	6	168319457	168319457	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:168319457G>A	uc003qwd.2	+	20	2870	c.2728G>A	c.(2728-2730)GAT>AAT	p.D910N	MLLT4_uc003qwb.1_Missense_Mutation_p.D895N|MLLT4_uc003qwc.1_Missense_Mutation_p.D911N|MLLT4_uc003qwg.1_Missense_Mutation_p.D220N	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	911					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)				T	MLL	AL								---	---	---	---
GPER	2852	broad.mit.edu	37	7	1132152	1132152	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1132152C>T	uc010ksd.1	+	2	1177	c.788C>T	c.(787-789)GCG>GTG	p.A263V	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPER_uc003sjz.1_Missense_Mutation_p.A263V|GPER_uc003ska.1_Missense_Mutation_p.A263V|GPER_uc003skb.2_Missense_Mutation_p.A263V	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	263	Helical; Name=6; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)														---	---	---	---
MICALL2	79778	broad.mit.edu	37	7	1484922	1484922	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1484922C>T	uc003skj.3	-	6	931	c.784G>A	c.(784-786)GCC>ACC	p.A262T	MICALL2_uc003ski.3_5'Flank	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	262						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)														---	---	---	---
TMEM184A	202915	broad.mit.edu	37	7	1588314	1588314	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1588314C>T	uc003skv.3	-	7	972	c.655G>A	c.(655-657)GGC>AGC	p.G219S	TMEM184A_uc003skt.3_Missense_Mutation_p.G198S|TMEM184A_uc003skw.3_Missense_Mutation_p.G24S	NM_001097620	NP_001091089	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	219						integral to membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)														---	---	---	---
EIF3B	8662	broad.mit.edu	37	7	2402723	2402723	+	Missense_Mutation	SNP	C	G	G	rs145413649		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2402723C>G	uc003slx.2	+	4	914	c.831C>G	c.(829-831)GAC>GAG	p.D277E	EIF3B_uc003sly.2_Missense_Mutation_p.D277E|EIF3B_uc003slz.1_Missense_Mutation_p.D238E|EIF3B_uc003sma.2_Missense_Mutation_p.D5E	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	277	Sufficient for interaction with EIF3E.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)														---	---	---	---
TTYH3	80727	broad.mit.edu	37	7	2687619	2687619	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2687619T>C	uc003smp.2	+	5	840	c.653T>C	c.(652-654)CTG>CCG	p.L218P	TTYH3_uc010ksn.2_Intron|TTYH3_uc003smq.2_Missense_Mutation_p.L47P	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	218	Helical; Name=3; (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)														---	---	---	---
SLC29A4	222962	broad.mit.edu	37	7	5330864	5330864	+	Silent	SNP	C	T	T	rs145785340		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5330864C>T	uc003sod.2	+	4	572	c.411C>T	c.(409-411)ACC>ACT	p.T137T	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Silent_p.T137T|SLC29A4_uc003soe.2_Silent_p.T137T	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	137	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)														---	---	---	---
KDELR2	11014	broad.mit.edu	37	7	6505847	6505847	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6505847G>A	uc003sqe.3	-	4	620	c.459C>T	c.(457-459)TTC>TTT	p.F153F	DAGLB_uc003sqd.3_Intron|KDELR2_uc003sqf.3_Intron	NM_006854	NP_006845	P33947	ERD22_HUMAN	KDEL receptor 2 isoform 1	153	Helical; (Potential).				intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	KDEL sequence binding|protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)														---	---	---	---
TMEM106B	54664	broad.mit.edu	37	7	12263969	12263969	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:12263969C>T	uc011jxk.1	+	5	799	c.399C>T	c.(397-399)GTC>GTT	p.V133V	TMEM106B_uc003ssh.2_Silent_p.V133V	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	133						integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)														---	---	---	---
SNX13	23161	broad.mit.edu	37	7	17908067	17908067	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:17908067C>T	uc003stw.1	-	9	1013	c.800G>A	c.(799-801)AGT>AAT	p.S267N	SNX13_uc003stv.2_Missense_Mutation_p.S267N|SNX13_uc010kuc.2_Missense_Mutation_p.S64N|SNX13_uc003stx.1_Missense_Mutation_p.S187N			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	267	PXA.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)																	---	---	---	---
TWIST1	7291	broad.mit.edu	37	7	19156576	19156576	+	Silent	SNP	C	T	T	rs144664279	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:19156576C>T	uc003sum.2	-	1	720	c.369G>A	c.(367-369)TCG>TCA	p.S123S		NM_000474	NP_000465	Q15672	TWST1_HUMAN	twist	123	Helix-loop-helix motif.				aortic valve morphogenesis|cellular response to hypoxia|embryonic camera-type eye formation|embryonic cranial skeleton morphogenesis|eyelid development in camera-type eye|muscle organ development|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of histone phosphorylation|negative regulation of osteoblast differentiation|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of cell motility|positive regulation of epithelial to mesenchymal transition|positive regulation of fatty acid beta-oxidation|positive regulation of monocyte chemotactic protein-1 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of tumor necrosis factor production|regulation of bone mineralization	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding RNA polymerase II transcription factor activity				0														Saethre-Chotzen_syndrome				---	---	---	---
ABCB5	340273	broad.mit.edu	37	7	20785017	20785017	+	Missense_Mutation	SNP	G	A	A	rs146066744	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:20785017G>A	uc003suw.3	+	17	2596	c.2050G>A	c.(2050-2052)GCA>ACA	p.A684T	ABCB5_uc010kuh.2_Missense_Mutation_p.A1129T	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	684	Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6																		---	---	---	---
CDCA7L	55536	broad.mit.edu	37	7	21946056	21946056	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:21946056G>A	uc010kuk.2	-	6	892	c.772C>T	c.(772-774)CGG>TGG	p.R258W	CDCA7L_uc003sve.3_Missense_Mutation_p.R224W|CDCA7L_uc010kul.2_Missense_Mutation_p.R212W|CDCA7L_uc003svf.3_Missense_Mutation_p.R257W	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	258					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0																		---	---	---	---
RAPGEF5	9771	broad.mit.edu	37	7	22197498	22197498	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:22197498A>G	uc003svg.2	-	15	1386	c.1073T>C	c.(1072-1074)GTA>GCA	p.V358A	RAPGEF5_uc011jyl.1_Missense_Mutation_p.V39A	NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	208					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
FAM126A	84668	broad.mit.edu	37	7	23018028	23018028	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:23018028G>A	uc003svm.3	-	4	448	c.193C>T	c.(193-195)CGC>TGC	p.R65C	FAM126A_uc003svn.3_5'UTR|FAM126A_uc011jyr.1_Missense_Mutation_p.R31C	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	65						cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1																		---	---	---	---
NOD1	10392	broad.mit.edu	37	7	30465314	30465314	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30465314G>A	uc003tav.2	-	14	3325	c.2802C>T	c.(2800-2802)AAC>AAT	p.N934N		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	934	LRR 9.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2																		---	---	---	---
BBS9	27241	broad.mit.edu	37	7	33195315	33195315	+	Splice_Site	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:33195315G>A	uc003tdn.1	+	4	841	c.328_splice	c.e4+1	p.G110_splice	BBS9_uc003tdo.1_Splice_Site_p.G110_splice|BBS9_uc003tdp.1_Splice_Site_p.G110_splice|BBS9_uc003tdq.1_Splice_Site_p.G110_splice|BBS9_uc010kwn.1_Splice_Site|BBS9_uc011kan.1_Splice_Site_p.G110_splice|BBS9_uc011kao.1_5'Flank	NM_198428	NP_940820			parathyroid hormone-responsive B1 isoform 2						fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)											Bardet-Biedl_syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	7	38402707	38402707	+	Intron	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:38402707C>A	uc003tgp.1	+						uc003tgs.1_Nonsense_Mutation_p.E38*					Homo sapiens cDNA FLJ43658 fis, clone SYNOV4004184.																														---	---	---	---
Unknown	0	broad.mit.edu	37	7	38402757	38402757	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:38402757T>C	uc003tgp.1	+						uc003tgs.1_Missense_Mutation_p.N21S					Homo sapiens cDNA FLJ43658 fis, clone SYNOV4004184.																														---	---	---	---
C7orf10	79783	broad.mit.edu	37	7	40899966	40899966	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:40899966C>T	uc003thn.1	+	14	1250	c.1205C>T	c.(1204-1206)CCG>CTG	p.P402L	C7orf10_uc003thm.1_Missense_Mutation_p.P398L|C7orf10_uc003tho.1_Missense_Mutation_p.P354L|C7orf10_uc003thp.1_RNA	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	409							transferase activity			ovary(2)	2																		---	---	---	---
GLI3	2737	broad.mit.edu	37	7	42004994	42004994	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:42004994G>T	uc011kbh.1	-	15	3768	c.3677C>A	c.(3676-3678)CCA>CAA	p.P1226Q	GLI3_uc011kbg.1_Missense_Mutation_p.P1167Q	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1226					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19														Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				---	---	---	---
STK17A	9263	broad.mit.edu	37	7	43635706	43635706	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:43635706T>G	uc003tih.2	+	2	564	c.413T>G	c.(412-414)CTG>CGG	p.L138R		NM_004760	NP_004751	Q9UEE5	ST17A_HUMAN	serine/threonine kinase 17a	138	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			skin(2)	2																		---	---	---	---
POLM	27434	broad.mit.edu	37	7	44113278	44113278	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44113278G>A	uc003tjt.2	-	10	1436	c.1344C>T	c.(1342-1344)AGC>AGT	p.S448S	POLM_uc003tjw.1_Silent_p.S67S|POLM_uc003tju.2_Silent_p.S411S|POLM_uc003tjx.2_Silent_p.S368S|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_Silent_p.S98S	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	448					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3													DNA_polymerases_(catalytic_subunits)					---	---	---	---
AEBP1	165	broad.mit.edu	37	7	44151594	44151594	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44151594G>A	uc003tkb.2	+	16	2287	c.1982G>A	c.(1981-1983)CGC>CAC	p.R661H	AEBP1_uc003tkc.3_Missense_Mutation_p.R236H|AEBP1_uc003tkd.2_5'UTR	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	661	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
MYO1G	64005	broad.mit.edu	37	7	45006267	45006267	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:45006267G>A	uc003tmh.2	-						MYO1G_uc003tmf.2_Intron|MYO1G_uc003tmg.2_Intron|MYO1G_uc010kym.2_Intron|MYO1G_uc003tmi.1_Silent_p.Y563Y	NM_033054	NP_149043			myosin IG							myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
CCM2	83605	broad.mit.edu	37	7	45103550	45103550	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:45103550C>A	uc003tmo.2	+	3	384	c.238C>A	c.(238-240)CTG>ATG	p.L80M	CCM2_uc003tmn.2_RNA|CCM2_uc003tmp.2_Missense_Mutation_p.L22M|CCM2_uc003tmq.2_RNA|CCM2_uc003tmr.2_Missense_Mutation_p.L80M|CCM2_uc011kcb.1_Missense_Mutation_p.L43M|CCM2_uc011kcc.1_Intron|CCM2_uc003tms.2_Missense_Mutation_p.L101M	NM_031443	NP_113631	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2 isoform 2	80	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding				0														Familial_Cerebral_Cavernous_Angioma				---	---	---	---
TBRG4	9238	broad.mit.edu	37	7	45142994	45142994	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:45142994C>T	uc003tmv.2	-	6	1240	c.1114G>A	c.(1114-1116)GTA>ATA	p.V372I	TBRG4_uc003tmu.2_Missense_Mutation_p.V197I|TBRG4_uc003tmw.2_Missense_Mutation_p.V262I|TBRG4_uc003tmx.2_Missense_Mutation_p.V262I|TBRG4_uc011kcd.1_Missense_Mutation_p.V383I	NM_004749	NP_004740	Q969Z0	TBRG4_HUMAN	cell cycle progression 2 protein isoform 1	372					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity				0																		---	---	---	---
ADCY1	107	broad.mit.edu	37	7	45748012	45748012	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:45748012G>A	uc003tne.3	+	18	2899	c.2881G>A	c.(2881-2883)GTT>ATT	p.V961I		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	961	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)													---	---	---	---
EGFR	1956	broad.mit.edu	37	7	55240694	55240694	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:55240694C>T	uc003tqk.2	+	17	2184	c.1938C>T	c.(1936-1938)ATC>ATT	p.I646I	EGFR_uc010kzg.1_Silent_p.I601I|EGFR_uc011kco.1_Silent_p.I593I	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	646	Helical; (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			---	---	---	---
ZNF117	51351	broad.mit.edu	37	7	64452895	64452895	+	5'Flank	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:64452895C>T	uc003ttr.2	-						ZNF117_uc011kdr.1_Silent_p.T167T	NM_015852	NP_056936			zinc finger protein 117							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)																---	---	---	---
AUTS2	26053	broad.mit.edu	37	7	70252292	70252292	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:70252292G>A	uc003tvw.3	+	18	3149	c.2406G>A	c.(2404-2406)TCG>TCA	p.S802S	AUTS2_uc003tvx.3_Silent_p.S778S|AUTS2_uc011keg.1_Silent_p.S254S	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	802										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)														---	---	---	---
WBSCR17	64409	broad.mit.edu	37	7	71142200	71142200	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:71142200G>A	uc003tvy.2	+	9	1409	c.1409G>A	c.(1408-1410)CGC>CAC	p.R470H	WBSCR17_uc003tvz.2_Missense_Mutation_p.R169H	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	470	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)																---	---	---	---
WBSCR17	64409	broad.mit.edu	37	7	71175921	71175921	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:71175921C>T	uc003tvy.2	+						WBSCR17_uc003tvz.2_Intron	NM_022479	NP_071924			UDP-GalNAc:polypeptide							Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)																---	---	---	---
POM121	9883	broad.mit.edu	37	7	72409869	72409869	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72409869T>C	uc003twk.2	+						POM121_uc003twj.2_Intron|POM121_uc010lam.1_Intron	NM_172020	NP_742017			nuclear pore membrane protein 121						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)																---	---	---	---
TRIM50	135892	broad.mit.edu	37	7	72738518	72738518	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72738518C>T	uc010lbd.1	-	2	393	c.268G>A	c.(268-270)GTG>ATG	p.V90M	FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Missense_Mutation_p.V90M|TRIM50_uc003txz.1_Missense_Mutation_p.V90M	NM_178125	NP_835226	Q86XT4	TRI50_HUMAN	tripartite motif protein 50A	90	B box-type.					cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1																OREG0018105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CLDN4	1364	broad.mit.edu	37	7	73245910	73245910	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73245910T>A	uc003tzi.3	+	1	718	c.379T>A	c.(379-381)TTG>ATG	p.L127M	RFC2_uc011kfa.1_Intron|CLDN4_uc003tzh.1_RNA	NM_001305	NP_001296	O14493	CLD4_HUMAN	claudin 4	127	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity				0		Lung NSC(55;0.159)																---	---	---	---
EIF4H	7458	broad.mit.edu	37	7	73604058	73604058	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73604058C>T	uc003uad.1	+	3	311	c.303C>T	c.(301-303)TAC>TAT	p.Y101Y	RFC2_uc011kfa.1_Intron|EIF4H_uc011kfg.1_Silent_p.Y101Y|EIF4H_uc010lbm.2_Silent_p.Y101Y|EIF4H_uc003uae.1_Silent_p.Y101Y|EIF4H_uc003uaf.1_RNA|MIR590_hsa-mir-590|MI0003602_5'Flank	NM_022170	NP_071496	Q15056	IF4H_HUMAN	eukaryotic translation initiation factor 4H	101	RRM.				interspecies interaction between organisms|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0																		---	---	---	---
LAT2	7462	broad.mit.edu	37	7	73638506	73638506	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73638506C>T	uc003uag.2	+	12	1157	c.607C>T	c.(607-609)CGC>TGC	p.R203C	RFC2_uc011kfa.1_Intron|LAT2_uc003uah.2_Missense_Mutation_p.R203C|LAT2_uc003uai.2_Missense_Mutation_p.R203C|LAT2_uc010lbo.2_RNA	NM_032464	NP_115853	Q9GZY6	NTAL_HUMAN	linker for activation of T cells family member	203	Cytoplasmic (Potential).				B cell activation|B cell receptor signaling pathway|calcium-mediated signaling|mast cell degranulation	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding				0																		---	---	---	---
DTX2	113878	broad.mit.edu	37	7	76110102	76110102	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:76110102G>A	uc003uff.3	+						DTX2_uc011kgk.1_Intron|DTX2_uc003ufg.3_Intron|DTX2_uc003ufh.3_Intron|DTX2_uc003ufj.3_Intron	NM_020892	NP_065943			deltex 2 isoform a						Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
C7orf23	79161	broad.mit.edu	37	7	86827314	86827314	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:86827314C>T	uc003uio.2	-	3	389	c.177G>A	c.(175-177)CCG>CCA	p.P59P		NM_024315	NP_077291	Q9BU79	CG023_HUMAN	chromosome 7 open reading frame 23	59						integral to membrane					0	Esophageal squamous(14;0.0058)|all_lung(186;0.191)|Lung NSC(181;0.192)														HNSCC(41;0.11)			---	---	---	---
STEAP4	79689	broad.mit.edu	37	7	87912268	87912268	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87912268G>C	uc003ujs.2	-	3	777	c.672C>G	c.(670-672)ATC>ATG	p.I224M	STEAP4_uc010lek.2_Intron|STEAP4_uc003ujt.2_Missense_Mutation_p.I224M	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	224					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)																	---	---	---	---
ZNF804B	219578	broad.mit.edu	37	7	88963633	88963633	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:88963633T>G	uc011khi.1	+	4	1875	c.1337T>G	c.(1336-1338)GTT>GGT	p.V446G		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	446						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)												HNSCC(36;0.09)			---	---	---	---
KRIT1	889	broad.mit.edu	37	7	91852279	91852279	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91852279C>T	uc003ulq.1	-	11	1439	c.1268G>A	c.(1267-1269)CGA>CAA	p.R423Q	KRIT1_uc010lev.1_Missense_Mutation_p.R180Q|KRIT1_uc003ulr.1_Missense_Mutation_p.R423Q|KRIT1_uc003uls.1_Missense_Mutation_p.R423Q|KRIT1_uc003ult.1_Missense_Mutation_p.R375Q|KRIT1_uc003ulu.1_Missense_Mutation_p.R423Q|KRIT1_uc003ulv.1_Missense_Mutation_p.R423Q	NM_194456	NP_919438	O00522	KRIT1_HUMAN	krev interaction trapped 1 isoform 1	423	FERM.				angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)											Familial_Cerebral_Cavernous_Angioma				---	---	---	---
ANKIB1	54467	broad.mit.edu	37	7	92027163	92027163	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92027163A>G	uc003ulw.2	+	19	2898	c.2522A>G	c.(2521-2523)GAC>GGC	p.D841G	ANKIB1_uc010lew.1_Missense_Mutation_p.D110G	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	841							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)															---	---	---	---
SLC25A13	10165	broad.mit.edu	37	7	95775901	95775901	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:95775901G>A	uc003uof.3	-	14	1610	c.1419C>T	c.(1417-1419)GTC>GTT	p.V473V	SLC25A13_uc003uog.3_Silent_p.V474V|SLC25A13_uc011kik.1_Silent_p.V365V	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	473	Solcar 2.				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)													---	---	---	---
ZNF394	84124	broad.mit.edu	37	7	99091276	99091276	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99091276C>A	uc003uqs.2	-	3	1723	c.1562G>T	c.(1561-1563)GGG>GTG	p.G521V	ZNF394_uc003uqt.2_Missense_Mutation_p.G314V	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	521					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)																	---	---	---	---
MCM7	4176	broad.mit.edu	37	7	99690627	99690627	+	Silent	SNP	C	T	T	rs139468339		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99690627C>T	uc003usw.1	-	15	2598	c.2088G>A	c.(2086-2088)GCG>GCA	p.A696A	MCM7_uc003usv.1_Silent_p.A520A|MCM7_uc003usx.1_Silent_p.A520A	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	696	Interaction with ATRIP.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)													---	---	---	---
PVRIG	79037	broad.mit.edu	37	7	99818219	99818219	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99818219C>T	uc003uue.2	+	5	891	c.519C>T	c.(517-519)GCC>GCT	p.A173A	GATS_uc003uty.3_Intron|GATS_uc003utz.3_Intron|GATS_uc003uua.3_Intron|GATS_uc010lgt.2_Intron|GATS_uc011kjl.1_Intron|GATS_uc010lgu.2_Intron|PVRIG_uc003uuf.1_Silent_p.A173A	NM_024070	NP_076975	Q6DKI7	PVRIG_HUMAN	poliovirus receptor related immunoglobulin	173	Helical; (Potential).					integral to membrane				skin(2)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
SPDYE3	441272	broad.mit.edu	37	7	99913460	99913460	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99913460A>G	uc003uug.1	+	2	363	c.123A>G	c.(121-123)TCA>TCG	p.S41S		NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	418											0																		---	---	---	---
FBXO24	26261	broad.mit.edu	37	7	100192158	100192158	+	Missense_Mutation	SNP	G	A	A	rs140728414		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100192158G>A	uc003uvm.1	+	6	1239	c.946G>A	c.(946-948)GTC>ATC	p.V316I	FBXO24_uc003uvl.1_Missense_Mutation_p.V302I|FBXO24_uc003uvn.1_Missense_Mutation_p.V11I|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Missense_Mutation_p.V354I|FBXO24_uc011kka.1_Missense_Mutation_p.V304I	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	316						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)																	---	---	---	---
GIGYF1	64599	broad.mit.edu	37	7	100282113	100282113	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100282113C>T	uc003uwg.1	-	13	2598	c.1589G>A	c.(1588-1590)CGC>CAC	p.R530H		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	530										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)																	---	---	---	---
GIGYF1	64599	broad.mit.edu	37	7	100283673	100283673	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100283673C>T	uc003uwg.1	-	9	1987	c.978G>A	c.(976-978)GAG>GAA	p.E326E		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	326										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)																	---	---	---	---
EPHB4	2050	broad.mit.edu	37	7	100403278	100403278	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100403278C>T	uc003uwn.1	-	15	3014	c.2523G>A	c.(2521-2523)CCG>CCA	p.P841P	EPHB4_uc003uwm.1_Silent_p.P748P|EPHB4_uc010lhj.1_Silent_p.P841P	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	841	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
SLC12A9	56996	broad.mit.edu	37	7	100454739	100454739	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100454739C>T	uc003uwp.2	+	5	840	c.698C>T	c.(697-699)CCG>CTG	p.P233L	SLC12A9_uc003uwo.1_Missense_Mutation_p.P144L|SLC12A9_uc003uwq.2_Missense_Mutation_p.P144L|SLC12A9_uc011kki.1_Intron|SLC12A9_uc003uwr.2_5'UTR|SLC12A9_uc003uws.2_5'UTR|SLC12A9_uc003uwt.2_5'UTR|SLC12A9_uc003uwv.2_5'Flank	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	233	Extracellular (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
TRIM56	81844	broad.mit.edu	37	7	100732369	100732369	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100732369C>T	uc003uxq.2	+	3	2007	c.1776C>T	c.(1774-1776)CAC>CAT	p.H592H	TRIM56_uc003uxr.2_Intron	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	592					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)																	---	---	---	---
CUX1	1523	broad.mit.edu	37	7	101845475	101845475	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:101845475C>T	uc003uyx.3	+	18	2936	c.2898C>T	c.(2896-2898)TTC>TTT	p.F966F	CUX1_uc003uys.3_Silent_p.F977F|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	966	CUT 2.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
LRRC17	10234	broad.mit.edu	37	7	102574619	102574619	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102574619C>T	uc003vau.2	+	2	648	c.259C>T	c.(259-261)CTG>TTG	p.L87L	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_Silent_p.L87L	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	87	LRR 1.				bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1																		---	---	---	---
PRKAR2B	5577	broad.mit.edu	37	7	106791470	106791470	+	Splice_Site	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:106791470T>C	uc003vdx.2	+	7	1018	c.843_splice	c.e7+2	p.E281_splice		NM_002736	NP_002727			cAMP-dependent protein kinase, regulatory						activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1																		---	---	---	---
PPP1R3A	5506	broad.mit.edu	37	7	113519436	113519436	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:113519436C>T	uc010ljy.1	-	4	1742	c.1711G>A	c.(1711-1713)GCA>ACA	p.A571T		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	571					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34																		---	---	---	---
CFTR	1080	broad.mit.edu	37	7	117171005	117171005	+	Missense_Mutation	SNP	A	G	G	rs121909031		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117171005A>G	uc003vjd.2	+	4	458	c.326A>G	c.(325-327)TAT>TGT	p.Y109C	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	109	ABC transmembrane type-1 1.|Extracellular (Potential).		Y -> C (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)									Cystic_Fibrosis				---	---	---	---
KCND2	3751	broad.mit.edu	37	7	119915439	119915439	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:119915439G>A	uc003vjj.1	+	1	1718	c.753G>A	c.(751-753)GCG>GCA	p.A251A		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	251	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)																	---	---	---	---
C7orf58	79974	broad.mit.edu	37	7	120781026	120781026	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:120781026G>C	uc003vjq.3	+	15	2292	c.1845G>C	c.(1843-1845)AAG>AAC	p.K615N	C7orf58_uc003vjs.3_Missense_Mutation_p.K615N|C7orf58_uc003vjt.3_Missense_Mutation_p.K395N	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	615						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)																	---	---	---	---
HYAL4	23553	broad.mit.edu	37	7	123508820	123508820	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:123508820C>A	uc003vlc.2	+	3	1131	c.493C>A	c.(493-495)CAG>AAG	p.Q165K	HYAL4_uc011knz.1_Missense_Mutation_p.Q165K	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	165	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1																		---	---	---	---
GCC1	79571	broad.mit.edu	37	7	127223030	127223030	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:127223030C>T	uc003vma.2	-	2	1784	c.1366G>A	c.(1366-1368)GTG>ATG	p.V456M		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	456	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2																		---	---	---	---
FSCN3	29999	broad.mit.edu	37	7	127235709	127235709	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:127235709C>T	uc003vmd.1	+	2	712	c.493C>T	c.(493-495)CGC>TGC	p.R165C	FSCN3_uc003vmc.1_Missense_Mutation_p.R120C|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_Missense_Mutation_p.R31C|FSCN3_uc010llc.1_Missense_Mutation_p.R165C	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	165						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1																		---	---	---	---
FLNC	2318	broad.mit.edu	37	7	128483862	128483862	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128483862G>A	uc003vnz.3	+	19	3033	c.2824G>A	c.(2824-2826)GTG>ATG	p.V942M	FLNC_uc003voa.3_Missense_Mutation_p.V942M	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	942	Filamin 7.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12																		---	---	---	---
FLNC	2318	broad.mit.edu	37	7	128494555	128494555	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128494555C>T	uc003vnz.3	+	41	7025	c.6816C>T	c.(6814-6816)AGC>AGT	p.S2272S	FLNC_uc003voa.3_Silent_p.S2239S	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2272	Filamin 20.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12																		---	---	---	---
FAM40B	57464	broad.mit.edu	37	7	129122851	129122851	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129122851C>T	uc011koy.1	+	20	2258	c.2218C>T	c.(2218-2220)CGT>TGT	p.R740C	FAM40B_uc003vow.2_Missense_Mutation_p.R740C|FAM40B_uc011koz.1_Missense_Mutation_p.R232C	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	740											0																		---	---	---	---
COPG2	26958	broad.mit.edu	37	7	130351756	130351756	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:130351756T>C	uc003vqh.1	-	3	194	c.104A>G	c.(103-105)AAT>AGT	p.N35S		NM_012133	NP_036265	Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2	35					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity				0	Melanoma(18;0.0435)																	---	---	---	---
PODXL	5420	broad.mit.edu	37	7	131191014	131191014	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:131191014C>T	uc003vqw.3	-						PODXL_uc003vqx.3_Intron	NM_001018111	NP_001018121			podocalyxin-like isoform 1 precursor						cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)																	---	---	---	---
PLXNA4	91584	broad.mit.edu	37	7	131895805	131895805	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:131895805G>T	uc003vra.3	-	10	2424	c.2195C>A	c.(2194-2196)TCT>TAT	p.S732Y		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	732	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1																		---	---	---	---
CHCHD3	54927	broad.mit.edu	37	7	132659927	132659927	+	Splice_Site	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:132659927A>G	uc003vre.2	-	4	505	c.369_splice	c.e4+1	p.L123_splice	CHCHD3_uc010lmi.2_Splice_Site|CHCHD3_uc003vrf.2_Missense_Mutation_p.V124A|CHCHD3_uc010lmj.2_5'UTR|CHCHD3_uc011kpn.1_Splice_Site_p.L123_splice	NM_017812	NP_060282			coiled-coil-helix-coiled-coil-helix domain						inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold				0																		---	---	---	---
CNOT4	4850	broad.mit.edu	37	7	135079001	135079001	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:135079001C>T	uc003vsv.1	-	10	1603	c.1296G>A	c.(1294-1296)TCG>TCA	p.S432S	CNOT4_uc003vss.2_Silent_p.S429S|CNOT4_uc011kpz.1_Silent_p.S429S|CNOT4_uc003vst.2_Silent_p.S432S|CNOT4_uc003vsu.1_Silent_p.S429S|CNOT4_uc011kpy.1_Silent_p.S432S	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	432					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
DGKI	9162	broad.mit.edu	37	7	137270094	137270094	+	Splice_Site	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:137270094T>C	uc003vtt.2	-	14	1427	c.1426_splice	c.e14-1	p.G476_splice	DGKI_uc003vtu.2_Splice_Site_p.G176_splice	NM_004717	NP_004708			diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
SVOPL	136306	broad.mit.edu	37	7	138314877	138314877	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138314877T>C	uc011kqh.1	-						SVOPL_uc003vue.2_Intron	NM_001139456	NP_001132928			SVOP-like isoform 1							integral to membrane	transmembrane transporter activity				0																		---	---	---	---
ZC3HAV1	56829	broad.mit.edu	37	7	138758625	138758625	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138758625T>C	uc003vun.2	-	7	2237	c.1849A>G	c.(1849-1851)ACA>GCA	p.T617A	ZC3HAV1_uc003vuo.2_Missense_Mutation_p.T78A|ZC3HAV1_uc003vup.2_Missense_Mutation_p.T617A	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	617	WWE.				response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
HIPK2	28996	broad.mit.edu	37	7	139268623	139268623	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139268623C>T	uc003vvf.3	-	13	3079	c.2905G>A	c.(2905-2907)GTG>ATG	p.V969M	HIPK2_uc003vvd.3_Missense_Mutation_p.V942M	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	969	Required for localization to nuclear speckles (By similarity).|Interaction with AXIN1 (By similarity).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)																	---	---	---	---
HIPK2	28996	broad.mit.edu	37	7	139315949	139315949	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139315949G>A	uc003vvf.3	-	4	1483	c.1309C>T	c.(1309-1311)CGT>TGT	p.R437C	HIPK2_uc003vvd.3_Missense_Mutation_p.R437C	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	437	Protein kinase.|Interaction with DAXX.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)																	---	---	---	---
DENND2A	27147	broad.mit.edu	37	7	140255465	140255465	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140255465G>A	uc010lnj.2	-	10	2153	c.2008C>T	c.(2008-2010)CGC>TGC	p.R670C	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.R670C|DENND2A_uc003vvw.2_Missense_Mutation_p.R670C|DENND2A_uc003vvx.2_Missense_Mutation_p.R670C	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	670	DENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)																	---	---	---	---
ADCK2	90956	broad.mit.edu	37	7	140379077	140379077	+	Silent	SNP	G	A	A	rs141910091		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140379077G>A	uc003vvy.1	+	3	1381	c.1203G>A	c.(1201-1203)ACG>ACA	p.T401T	ADCK2_uc003vvz.2_Silent_p.T401T	NM_052853	NP_443085	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	401	Protein kinase.					integral to membrane	ATP binding|protein serine/threonine kinase activity				0	Melanoma(164;0.00956)																	---	---	---	---
AGK	55750	broad.mit.edu	37	7	141351372	141351372	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141351372G>A	uc003vwi.2	+	15	1265	c.1094G>A	c.(1093-1095)TGT>TAT	p.C365Y	AGK_uc011krg.1_RNA	NM_018238	NP_060708	Q53H12	AGK_HUMAN	acylglycerol kinase precursor	365					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			ovary(1)|breast(1)	2	Melanoma(164;0.0171)																	---	---	---	---
KIAA1147	57189	broad.mit.edu	37	7	141386388	141386388	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141386388A>G	uc003vwk.2	-	2	339	c.339T>C	c.(337-339)AGT>AGC	p.S113S		NM_001080392	NP_001073861	A4D1U4	LCHN_HUMAN	hypothetical protein LOC57189	113										ovary(1)	1	Melanoma(164;0.0171)																	---	---	---	---
EPHB6	2051	broad.mit.edu	37	7	142568426	142568426	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142568426A>G	uc011kst.1	+	19	3732	c.2945A>G	c.(2944-2946)CAG>CGG	p.Q982R	EPHB6_uc011ksu.1_Missense_Mutation_p.Q982R|EPHB6_uc003wbs.2_Missense_Mutation_p.Q690R|EPHB6_uc003wbt.2_Missense_Mutation_p.Q456R|EPHB6_uc003wbu.2_Missense_Mutation_p.Q690R|EPHB6_uc003wbv.2_Missense_Mutation_p.Q366R	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	982	SAM.|Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)																	---	---	---	---
TRPV6	55503	broad.mit.edu	37	7	142574151	142574151	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142574151C>T	uc003wbx.1	-						TRPV6_uc003wbw.1_Intron|TRPV6_uc010lou.1_Intron	NM_018646	NP_061116			transient receptor potential cation channel,						regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)																	---	---	---	---
EPHA1	2041	broad.mit.edu	37	7	143090966	143090966	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143090966C>T	uc003wcz.2	-							NM_005232	NP_005223			ephrin receptor EphA1 precursor							integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)																---	---	---	---
TAS2R60	338398	broad.mit.edu	37	7	143140741	143140741	+	Missense_Mutation	SNP	C	T	T	rs148979644		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143140741C>T	uc011ktg.1	+	1	196	c.196C>T	c.(196-198)CGC>TGC	p.R66C	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	66	Extracellular (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)																	---	---	---	---
OR6B1	135946	broad.mit.edu	37	7	143701922	143701922	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143701922T>C	uc003wdt.1	+	1	833	c.833T>C	c.(832-834)ATT>ACT	p.I278T		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)																	---	---	---	---
OR2A14	135941	broad.mit.edu	37	7	143826976	143826976	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143826976G>A	uc011kua.1	+	1	771	c.771G>A	c.(769-771)ACG>ACA	p.T257T		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)																	---	---	---	---
NOBOX	135935	broad.mit.edu	37	7	144101645	144101645	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:144101645G>A	uc011kue.1	-							NM_001080413	NP_001073882			NOBOX oogenesis homeobox						cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)																	---	---	---	---
ZNF786	136051	broad.mit.edu	37	7	148768017	148768017	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148768017G>A	uc003wfh.2	-	4	1984	c.1847C>T	c.(1846-1848)ACG>ATG	p.T616M	ZNF786_uc011kuk.1_Missense_Mutation_p.T579M|ZNF786_uc003wfi.2_Missense_Mutation_p.T530M	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)															---	---	---	---
ZNF746	155061	broad.mit.edu	37	7	149171723	149171723	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149171723C>T	uc003wfw.2	-	7	1958	c.1687G>A	c.(1687-1689)GTG>ATG	p.V563M	ZNF746_uc010lpi.2_Missense_Mutation_p.V564M	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	563					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)															---	---	---	---
SLC4A2	6522	broad.mit.edu	37	7	150771384	150771384	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150771384C>T	uc003wit.3	+						SLC4A2_uc011kve.1_Intron|SLC4A2_uc003wiu.3_Intron|SLC4A2_uc003wiv.3_Intron	NM_003040	NP_003031			solute carrier family 4, anion exchanger, member						bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151856005	151856005	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151856005G>A	uc003wla.2	-	44	11832	c.11613C>T	c.(11611-11613)GAC>GAT	p.D3871D	MLL3_uc003wkz.2_Silent_p.D2932D|MLL3_uc003wkx.2_5'Flank|MLL3_uc003wky.2_Silent_p.D1380D	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3871					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
DPP6	1804	broad.mit.edu	37	7	154263935	154263935	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154263935A>T	uc003wlk.2	+	5	690	c.561A>T	c.(559-561)TTA>TTT	p.L187F	DPP6_uc003wli.2_Missense_Mutation_p.L123F|DPP6_uc003wlj.2_Missense_Mutation_p.L187F|DPP6_uc003wlm.2_Missense_Mutation_p.L125F|DPP6_uc011kvq.1_Missense_Mutation_p.L125F	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	187	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)															---	---	---	---
PTPRN2	5799	broad.mit.edu	37	7	157370836	157370836	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:157370836C>T	uc003wno.2	-						PTPRN2_uc003wnp.2_Intron|PTPRN2_uc003wnq.2_Intron|PTPRN2_uc003wnr.2_Intron|PTPRN2_uc011kwa.1_Intron	NM_002847	NP_002838			protein tyrosine phosphatase, receptor type, N							integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)														---	---	---	---
VIPR2	7434	broad.mit.edu	37	7	158896468	158896468	+	Missense_Mutation	SNP	C	T	T	rs149519347		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:158896468C>T	uc003woh.2	-	4	523	c.337G>A	c.(337-339)GAC>AAC	p.D113N	VIPR2_uc010lqx.2_RNA|VIPR2_uc010lqy.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	113	Extracellular (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	3245111	3245111	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:3245111G>T	uc011kwk.1	-	18	3080	c.2690C>A	c.(2689-2691)ACT>AAT	p.T897N	CSMD1_uc011kwj.1_Missense_Mutation_p.T289N|CSMD1_uc003wqe.2_Missense_Mutation_p.T53N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	897	Extracellular (Potential).|Sushi 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
DEFA4	1669	broad.mit.edu	37	8	6794409	6794409	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6794409C>T	uc003wqu.1	-	2	64	c.13G>A	c.(13-15)GCC>ACC	p.A5T		NM_001925	NP_001916	P12838	DEF4_HUMAN	defensin, alpha 4 preproprotein	5					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				large_intestine(1)	1				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)														---	---	---	---
TNKS	8658	broad.mit.edu	37	8	9609295	9609295	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:9609295C>T	uc003wss.2	+	19	3014	c.3009C>T	c.(3007-3009)GCC>GCT	p.A1003A	TNKS_uc011kww.1_Silent_p.A766A|TNKS_uc010lrt.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1003					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)														---	---	---	---
RP1L1	94137	broad.mit.edu	37	8	10469597	10469597	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:10469597G>A	uc003wtc.2	-	4	2240	c.2011C>T	c.(2011-2013)CGC>TGC	p.R671C		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	671					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)														---	---	---	---
FAM86B1	85002	broad.mit.edu	37	8	12044028	12044028	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:12044028C>T	uc010lse.2	-	5	518	c.473G>A	c.(472-474)CGG>CAG	p.R158Q	FAM66D_uc011kxp.1_Intron|FAM86B1_uc003wvf.3_Intron|FAM86B1_uc003wvi.3_Intron|FAM86B1_uc010lsd.2_Intron|FAM86B1_uc003wvh.3_Intron|FAM86B1_uc011kxq.1_Intron|FAM86B1_uc010lsf.2_Intron|FAM86B1_uc003wvj.3_Missense_Mutation_p.R92Q|FAM86B1_uc003wvk.3_Missense_Mutation_p.R192Q|FAM86B1_uc010lsg.2_Intron|FAM86B1_uc003wvl.3_Intron	NM_001083537	NP_001077006	Q8N7N1	F86B1_HUMAN	hypothetical protein LOC85002	158											0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.0965)														---	---	---	---
SGCZ	137868	broad.mit.edu	37	8	13965704	13965704	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:13965704C>T	uc003wwq.2	-	6	1248	c.588G>A	c.(586-588)CCG>CCA	p.P196P	SGCZ_uc010lss.2_Silent_p.P149P	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	183	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)														---	---	---	---
MTUS1	57509	broad.mit.edu	37	8	17503472	17503472	+	Missense_Mutation	SNP	G	A	A	rs148435996	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17503472G>A	uc003wxv.2	-	15	4250	c.3776C>T	c.(3775-3777)TCG>TTG	p.S1259L	MTUS1_uc003wxt.2_Missense_Mutation_p.S506L|MTUS1_uc011kyg.1_Missense_Mutation_p.S404L|MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.S1205L|MTUS1_uc003wxs.2_Missense_Mutation_p.S425L	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	1259						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)														---	---	---	---
MTUS1	57509	broad.mit.edu	37	8	17611433	17611433	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17611433C>T	uc003wxv.2	-	2	2358	c.1884G>A	c.(1882-1884)GGG>GGA	p.G628G	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Silent_p.G628G|MTUS1_uc010lsz.2_Silent_p.G628G	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	628						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)														---	---	---	---
MTUS1	57509	broad.mit.edu	37	8	17612446	17612446	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17612446C>T	uc003wxv.2	-	2	1345	c.871G>A	c.(871-873)GCA>ACA	p.A291T	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.A291T|MTUS1_uc010lsz.2_Missense_Mutation_p.A291T	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	291						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)														---	---	---	---
CSGALNACT1	55790	broad.mit.edu	37	8	19277935	19277935	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:19277935T>C	uc011kyn.1	-	7	2112	c.1048A>G	c.(1048-1050)AGC>GGC	p.S350G	CSGALNACT1_uc011kyo.1_Missense_Mutation_p.S350G|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Missense_Mutation_p.S349G	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	350	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)														---	---	---	---
NPM2	10361	broad.mit.edu	37	8	21882970	21882970	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21882970C>T	uc003xab.2	+	3	740	c.82C>T	c.(82-84)CGG>TGG	p.R28W	NPM2_uc003xac.2_Missense_Mutation_p.R28W|NPM2_uc003xad.2_Missense_Mutation_p.R28W|NPM2_uc003xae.2_Missense_Mutation_p.R28W|NPM2_uc003xaf.2_Missense_Mutation_p.R28W	NM_182795	NP_877724	Q86SE8	NPM2_HUMAN	nucleoplasmin 2	28					chromatin remodeling|embryo development|oocyte differentiation|positive regulation of meiosis|regulation of exit from mitosis|single fertilization	cytoplasmic chromatin|nuclear chromatin	histone binding|nucleic acid binding				0				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)														---	---	---	---
PDLIM2	64236	broad.mit.edu	37	8	22452116	22452116	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22452116G>A	uc003xcc.1	+	10	1189	c.1055G>A	c.(1054-1056)CGG>CAG	p.R352Q		NM_176871	NP_789847	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 isoform 1	Error:Variant_position_missing_in_Q96JY6_after_alignment						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)														---	---	---	---
CHMP7	91782	broad.mit.edu	37	8	23106740	23106740	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23106740G>A	uc003xdc.2	+	3	965	c.317G>A	c.(316-318)CGG>CAG	p.R106Q	CHMP7_uc011kzs.1_Intron|CHMP7_uc003xdd.2_5'UTR	NM_152272	NP_689485	Q8WUX9	CHMP7_HUMAN	CHMP family, member 7	106					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity				0		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)														---	---	---	---
ENTPD4	9583	broad.mit.edu	37	8	23291937	23291937	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23291937C>T	uc003xdl.2	-	12	1679	c.1515G>A	c.(1513-1515)TCG>TCA	p.S505S	ENTPD4_uc011kzu.1_Silent_p.S497S|ENTPD4_uc003xdm.2_Silent_p.S497S|ENTPD4_uc011kzv.1_Silent_p.S505S	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	505	Lumenal (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)														---	---	---	---
ENTPD4	9583	broad.mit.edu	37	8	23292942	23292942	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23292942C>T	uc003xdl.2	-	11	1587	c.1423G>A	c.(1423-1425)GGA>AGA	p.G475R	ENTPD4_uc011kzu.1_Missense_Mutation_p.G467R|ENTPD4_uc003xdm.2_Missense_Mutation_p.G467R|ENTPD4_uc011kzv.1_Missense_Mutation_p.G475R	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	475	Lumenal (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)														---	---	---	---
ADAM28	10863	broad.mit.edu	37	8	24171018	24171018	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:24171018C>T	uc003xdy.2	+	6	584	c.501C>T	c.(499-501)AGC>AGT	p.S167S	ADAM28_uc003xdx.2_Silent_p.S167S|ADAM28_uc011kzz.1_Intron|ADAM28_uc011laa.1_RNA	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	167	Cysteine switch (By similarity).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)														---	---	---	---
ADAM28	10863	broad.mit.edu	37	8	24187564	24187564	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:24187564A>T	uc003xdy.2	+	11	1122	c.1039A>T	c.(1039-1041)ATG>TTG	p.M347L	ADAM28_uc003xdx.2_Missense_Mutation_p.M347L|ADAM28_uc011kzz.1_Missense_Mutation_p.M114L|ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Missense_Mutation_p.M34L	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	347	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)														---	---	---	---
HMBOX1	79618	broad.mit.edu	37	8	28902895	28902895	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28902895A>G	uc003xhd.3	+	7	1211	c.869A>G	c.(868-870)CAA>CGA	p.Q290R	HMBOX1_uc010lvd.2_Missense_Mutation_p.Q290R|HMBOX1_uc003xhc.3_Missense_Mutation_p.Q290R|HMBOX1_uc010lve.2_RNA|HMBOX1_uc003xhe.2_Missense_Mutation_p.Q290R|HMBOX1_uc011lay.1_Missense_Mutation_p.Q290R|HMBOX1_uc003xhf.2_Missense_Mutation_p.Q278R|HMBOX1_uc003xhg.2_Missense_Mutation_p.Q278R	NM_001135726	NP_001129198	Q6NT76	HMBX1_HUMAN	homeobox containing 1	290	Homeobox.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)														---	---	---	---
UNC5D	137970	broad.mit.edu	37	8	35544067	35544067	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:35544067T>C	uc003xjr.1	+	7	1252	c.924T>C	c.(922-924)GAT>GAC	p.D308D	UNC5D_uc003xjs.1_Silent_p.D303D|UNC5D_uc003xjt.1_Silent_p.D77D	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	308	Extracellular (Potential).|TSP type-1 2.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)														---	---	---	---
GPR124	25960	broad.mit.edu	37	8	37697634	37697634	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:37697634C>T	uc003xkj.2	+						GPR124_uc010lvy.2_Intron	NM_032777	NP_116166			G protein-coupled receptor 124 precursor						central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)															---	---	---	---
ASH2L	9070	broad.mit.edu	37	8	37967974	37967974	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:37967974G>A	uc003xkt.3	+	4	537	c.479G>A	c.(478-480)CGG>CAG	p.R160Q	ASH2L_uc011lbk.1_Missense_Mutation_p.R21Q|ASH2L_uc003xku.3_Missense_Mutation_p.R66Q|ASH2L_uc010lwa.2_Missense_Mutation_p.R66Q	NM_004674	NP_004665	Q9UBL3	ASH2L_HUMAN	ash2-like isoform a	160					hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)																---	---	---	---
FGFR1	2260	broad.mit.edu	37	8	38282177	38282177	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38282177G>A	uc003xlp.2	-	7	1728	c.786C>T	c.(784-786)CCC>CCT	p.P262P	FGFR1_uc011lbo.1_Silent_p.P260P|FGFR1_uc011lbp.1_Silent_p.P173P|FGFR1_uc011lbq.1_Silent_p.P171P|FGFR1_uc010lwk.2_Silent_p.P254P|FGFR1_uc011lbr.1_RNA|FGFR1_uc011lbs.1_Silent_p.P102P|FGFR1_uc011lbt.1_Silent_p.P171P|FGFR1_uc011lbu.1_Silent_p.P293P|FGFR1_uc011lbv.1_Silent_p.P260P|FGFR1_uc011lbw.1_Silent_p.P173P|FGFR1_uc011lbx.1_Silent_p.P173P|FGFR1_uc003xlv.2_Silent_p.P173P|FGFR1_uc003xlu.2_Silent_p.P171P	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	262	Ig-like C2-type 3.|Extracellular (Potential).				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						---	---	---	---
HTRA4	203100	broad.mit.edu	37	8	38840069	38840069	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38840069T>C	uc003xmj.2	+	7	1282	c.1167T>C	c.(1165-1167)ACT>ACC	p.T389T		NM_153692	NP_710159	P83105	HTRA4_HUMAN	HtrA serine peptidase 4 precursor	389	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)															---	---	---	---
ADAM32	203102	broad.mit.edu	37	8	39131867	39131867	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39131867C>T	uc003xmt.3	+	21	2483	c.2238C>T	c.(2236-2238)AGC>AGT	p.S746S	ADAM32_uc011lch.1_Silent_p.S647S|ADAM32_uc003xmu.3_Intron|ADAM32_uc003xmv.2_Intron	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	746	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)															---	---	---	---
ANK1	286	broad.mit.edu	37	8	41522389	41522389	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41522389G>A	uc003xok.2	-						NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Intron|ANK1_uc003xoi.2_Intron|ANK1_uc003xoj.2_Intron|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Intron|ANK1_uc011lcl.1_Silent_p.S51S|ANK1_uc003xod.2_Silent_p.S51S|ANK1_uc003xoc.2_Silent_p.S51S|ANK1_uc003xof.2_Silent_p.S51S	NM_020476	NP_065209			ankyrin 1 isoform 1						axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)															---	---	---	---
ANK1	286	broad.mit.edu	37	8	41575732	41575732	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41575732A>G	uc003xok.2	-						NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Intron|ANK1_uc003xoj.2_Intron|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Intron	NM_020476	NP_065209			ankyrin 1 isoform 1						axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)															---	---	---	---
HOOK3	84376	broad.mit.edu	37	8	42812253	42812253	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42812253C>A	uc003xpr.2	+	7	727	c.485C>A	c.(484-486)TCT>TAT	p.S162Y	HOOK3_uc010lxq.1_Missense_Mutation_p.S162Y	NM_032410	NP_115786	Q86VS8	HOOK3_HUMAN	golgi-associated microtubule-binding protein	162	Sufficient for interaction with microtubules.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			ovary(1)|breast(1)	2	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)					T	RET	papillary thyroid								---	---	---	---
HGSNAT	138050	broad.mit.edu	37	8	43048942	43048942	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:43048942C>A	uc003xpx.3	+	14	1468	c.1420C>A	c.(1420-1422)CTG>ATG	p.L474M		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	502	Helical; (Potential).				lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)															---	---	---	---
KIAA0146	23514	broad.mit.edu	37	8	48641512	48641512	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48641512G>T	uc003xqd.2	+	18	2462	c.2453G>T	c.(2452-2454)GGG>GTG	p.G818V	KIAA0146_uc011ldc.1_Missense_Mutation_p.G748V|KIAA0146_uc011ldd.1_Missense_Mutation_p.G758V|KIAA0146_uc003xqe.2_Missense_Mutation_p.G293V|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc010lxt.2_Intron|KIAA0146_uc011ldf.1_Missense_Mutation_p.G323V|KIAA0146_uc011ldg.1_Missense_Mutation_p.G308V|KIAA0146_uc003xqg.1_Intron	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	818											0		Lung NSC(58;0.175)																---	---	---	---
MCM4	4173	broad.mit.edu	37	8	48875312	48875312	+	Intron	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48875312C>A	uc003xqk.1	+						PRKDC_uc003xqi.2_5'Flank|PRKDC_uc003xqj.2_5'Flank|PRKDC_uc011ldh.1_5'Flank|MCM4_uc003xql.1_Intron|MCM4_uc011ldi.1_Intron|MCM4_uc010lxw.1_Intron	NM_182746	NP_877423			minichromosome maintenance complex component 4						cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)																---	---	---	---
SNAI2	6591	broad.mit.edu	37	8	49832564	49832564	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:49832564G>A	uc003xqp.2	-	2	680	c.516C>T	c.(514-516)GGC>GGT	p.G172G		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	172	C2H2-type 2.				canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)																---	---	---	---
RP1	6101	broad.mit.edu	37	8	55542602	55542602	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:55542602C>G	uc003xsd.1	+	4	6308	c.6160C>G	c.(6160-6162)CTC>GTC	p.L2054V	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	2054					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)															---	---	---	---
TGS1	96764	broad.mit.edu	37	8	56723563	56723563	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:56723563A>G	uc003xsj.3	+	11	2654	c.2267A>G	c.(2266-2268)AAG>AGG	p.K756R	TGS1_uc010lyh.2_Intron	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	756	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)															---	---	---	---
NSMAF	8439	broad.mit.edu	37	8	59512542	59512542	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:59512542G>A	uc003xtt.2	-	17	1533	c.1319C>T	c.(1318-1320)ACG>ATG	p.T440M	NSMAF_uc011lee.1_Missense_Mutation_p.T471M	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	440	BEACH.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)																---	---	---	---
TOX	9760	broad.mit.edu	37	8	59872540	59872540	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:59872540T>G	uc003xtw.1	-	2	351	c.130A>C	c.(130-132)ATG>CTG	p.M44L		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	44						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)																---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61769375	61769375	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61769375G>A	uc003xue.2	+	34	8013	c.7536G>A	c.(7534-7536)AGG>AGA	p.R2512R		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2512					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
CYP7B1	9420	broad.mit.edu	37	8	65527711	65527711	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:65527711C>T	uc003xvj.2	-	4	1133	c.929G>A	c.(928-930)CGG>CAG	p.R310Q		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	310					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)																---	---	---	---
ADHFE1	137872	broad.mit.edu	37	8	67369066	67369066	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67369066A>G	uc003xwb.3	+	11	1035	c.1001A>G	c.(1000-1002)TAC>TGC	p.Y334C	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Missense_Mutation_p.Y286C|ADHFE1_uc003xwe.3_RNA|ADHFE1_uc003xwf.3_RNA|ADHFE1_uc011les.1_Missense_Mutation_p.Y264C	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	334					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)															---	---	---	---
C8orf44	56260	broad.mit.edu	37	8	67590095	67590095	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67590095C>T	uc003xwo.1	+	2	305	c.152C>T	c.(151-153)GCC>GTC	p.A51V	SGK3_uc003xwp.2_Intron|C8orf44_uc003xwq.1_Missense_Mutation_p.A51V	NM_019607	NP_062553	Q96CB5	CH044_HUMAN	hypothetical protein LOC56260	51											0	Breast(64;0.186)		Epithelial(68;0.000959)|OV - Ovarian serous cystadenocarcinoma(28;0.00318)|all cancers(69;0.00363)|BRCA - Breast invasive adenocarcinoma(89;0.149)															---	---	---	---
ARFGEF1	10565	broad.mit.edu	37	8	68170430	68170430	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68170430G>A	uc003xxo.1	-	16	2721	c.2331C>T	c.(2329-2331)TTC>TTT	p.F777F	ARFGEF1_uc003xxl.1_Silent_p.F231F	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	777	SEC7.				exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)															---	---	---	---
KCNB2	9312	broad.mit.edu	37	8	73849681	73849681	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:73849681C>T	uc003xzb.2	+	3	2679	c.2091C>T	c.(2089-2091)ACC>ACT	p.T697T		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	697	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)															---	---	---	---
TCEB1	6921	broad.mit.edu	37	8	74859040	74859040	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:74859040T>C	uc003xzx.1	-	4	249	c.164A>G	c.(163-165)AAC>AGC	p.N55S	TCEB1_uc003xzy.1_Missense_Mutation_p.N55S|TCEB1_uc003xzz.1_Missense_Mutation_p.N39S|TCEB1_uc003yaa.1_Missense_Mutation_p.N55S	NM_005648	NP_005639	Q15369	ELOC_HUMAN	elongin C	55					interspecies interaction between organisms|positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm	protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0136)|all cancers(69;0.0431)|BRCA - Breast invasive adenocarcinoma(89;0.0499)															---	---	---	---
HNF4G	3174	broad.mit.edu	37	8	76456166	76456166	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:76456166A>C	uc003yaq.2	+	3	368	c.98A>C	c.(97-99)AAG>ACG	p.K33T	HNF4G_uc003yap.1_Missense_Mutation_p.K33T|HNF4G_uc003yar.2_Missense_Mutation_p.K70T	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	33	Nuclear receptor.				endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)															---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77766792	77766792	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77766792G>A	uc003yav.2	+	10	7887	c.7500G>A	c.(7498-7500)CCG>CCA	p.P2500P	ZFHX4_uc003yau.1_Silent_p.P2545P|ZFHX4_uc003yaw.1_Silent_p.P2500P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2500						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77767737	77767737	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77767737C>T	uc003yav.2	+	10	8832	c.8445C>T	c.(8443-8445)TGC>TGT	p.C2815C	ZFHX4_uc003yau.1_Silent_p.C2860C|ZFHX4_uc003yaw.1_Silent_p.C2815C	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2815						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77768336	77768336	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77768336C>T	uc003yav.2	+	10	9431	c.9044C>T	c.(9043-9045)GCA>GTA	p.A3015V	ZFHX4_uc003yau.1_Missense_Mutation_p.A3060V|ZFHX4_uc003yaw.1_Missense_Mutation_p.A3015V	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3015						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
STMN2	11075	broad.mit.edu	37	8	80567284	80567284	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:80567284G>A	uc003ybj.2	+	4	518	c.467G>A	c.(466-468)CGT>CAT	p.R156H	STMN2_uc010lzp.2_RNA|STMN2_uc011lfn.1_Intron	NM_007029	NP_008960	Q93045	STMN2_HUMAN	superiorcervical ganglia, neural specific 10	156	Potential.				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)															---	---	---	---
ZBTB10	65986	broad.mit.edu	37	8	81411872	81411872	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:81411872A>G	uc003ybx.3	+	2	1714	c.1116A>G	c.(1114-1116)GGA>GGG	p.G372G	ZBTB10_uc003ybv.3_Silent_p.G80G|ZBTB10_uc003ybw.3_Silent_p.G372G|ZBTB10_uc010lzt.2_Silent_p.G372G	NM_001105539	NP_001099009	Q96DT7	ZBT10_HUMAN	zinc finger and BTB domain containing 10 isoform	372	BTB.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)	1	all_cancers(3;1.68e-09)|all_epithelial(4;5.13e-11)|Lung NSC(7;1.75e-07)|all_lung(9;7.38e-07)|Breast(3;2.96e-06)		BRCA - Breast invasive adenocarcinoma(6;0.000434)|Epithelial(68;0.00486)|all cancers(69;0.0296)															---	---	---	---
WWP1	11059	broad.mit.edu	37	8	87473498	87473498	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:87473498T>C	uc003ydt.2	+	23	2825	c.2545T>C	c.(2545-2547)TTC>CTC	p.F849L		NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	849	HECT.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2																		---	---	---	---
DCAF4L2	138009	broad.mit.edu	37	8	88885973	88885973	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:88885973C>T	uc003ydz.2	-	1	324	c.227G>A	c.(226-228)CGC>CAC	p.R76H		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	76										ovary(1)	1																		---	---	---	---
MMP16	4325	broad.mit.edu	37	8	89198806	89198806	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:89198806G>A	uc003yeb.3	-	3	585	c.303C>T	c.(301-303)TGC>TGT	p.C101C	MMP16_uc003yec.2_Silent_p.C101C	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	101	Cysteine switch (By similarity).	Zinc; in inhibited form (By similarity).			collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8																		---	---	---	---
KLF10	7071	broad.mit.edu	37	8	103663847	103663847	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103663847G>A	uc011lhk.1	-	3	867	c.713C>T	c.(712-714)ACG>ATG	p.T238M	KLF10_uc011lhj.1_Missense_Mutation_p.T227M	NM_005655	NP_005646	Q13118	KLF10_HUMAN	Kruppel-like factor 10 isoform a	238					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)													OREG0018913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZFPM2	23414	broad.mit.edu	37	8	106813836	106813836	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:106813836T>C	uc003ymd.2	+	8	1549	c.1526T>C	c.(1525-1527)ATG>ACG	p.M509T	ZFPM2_uc011lhs.1_Missense_Mutation_p.M240T	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	509					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)															---	---	---	---
OXR1	55074	broad.mit.edu	37	8	107763096	107763096	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:107763096C>T	uc011lht.1	+	16	2651	c.2552C>T	c.(2551-2553)ACG>ATG	p.T851M	OXR1_uc003ymf.2_Missense_Mutation_p.T823M|OXR1_uc011lhu.1_Missense_Mutation_p.T816M|OXR1_uc010mcg.2_RNA|OXR1_uc010mch.2_Missense_Mutation_p.T479M|OXR1_uc003ymk.2_Missense_Mutation_p.T220M|OXR1_uc003yml.2_Missense_Mutation_p.T193M	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	851					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)															---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110432768	110432768	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110432768C>T	uc003yne.2	+	23	2650	c.2546C>T	c.(2545-2547)CCT>CTT	p.P849L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	849	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	113529433	113529433	+	Missense_Mutation	SNP	C	T	T	rs138068999		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113529433C>T	uc003ynu.2	-	28	4745	c.4586G>A	c.(4585-4587)CGT>CAT	p.R1529H	CSMD3_uc003yns.2_Missense_Mutation_p.R801H|CSMD3_uc003ynt.2_Missense_Mutation_p.R1489H|CSMD3_uc011lhx.1_Missense_Mutation_p.R1425H	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1529	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---	---
TRPS1	7227	broad.mit.edu	37	8	116426706	116426706	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:116426706C>T	uc003ynz.2	-	6	3850	c.3391G>A	c.(3391-3393)GTG>ATG	p.V1131M	TRPS1_uc011lhy.1_Missense_Mutation_p.V1135M|TRPS1_uc003yny.2_Missense_Mutation_p.V1144M|TRPS1_uc010mcy.2_Missense_Mutation_p.V1131M	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	1131	Mediates interaction with RNF4 (By similarity).				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)											Langer-Giedion_syndrome				---	---	---	---
TRPS1	7227	broad.mit.edu	37	8	116430602	116430602	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:116430602C>T	uc003ynz.2	-	5	3199	c.2740G>A	c.(2740-2742)GGA>AGA	p.G914R	TRPS1_uc011lhy.1_Missense_Mutation_p.G918R|TRPS1_uc003yny.2_Missense_Mutation_p.G927R|TRPS1_uc010mcy.2_Missense_Mutation_p.G914R	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	914	GATA-type.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)											Langer-Giedion_syndrome				---	---	---	---
C8orf85	441376	broad.mit.edu	37	8	117950492	117950492	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:117950492G>A	uc003yof.2	+	1	29	c.10G>A	c.(10-12)GGG>AGG	p.G4R		NM_001025357	NP_001020528	Q4LEZ3	AARD_HUMAN	alanine and arginine-rich domain-containing	4											0																		---	---	---	---
EXT1	2131	broad.mit.edu	37	8	119123086	119123086	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:119123086G>T	uc003yok.1	-	1	973	c.200C>A	c.(199-201)CCT>CAT	p.P67H		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	67	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)					Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				---	---	---	---
ZHX1	11244	broad.mit.edu	37	8	124267604	124267604	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124267604G>A	uc003yqe.2	-	3	1013	c.583C>T	c.(583-585)CGG>TGG	p.R195W	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.R195W|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.R195W	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	195					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)															---	---	---	---
KLHL38	340359	broad.mit.edu	37	8	124663913	124663913	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124663913G>A	uc003yqs.1	-	1	1278	c.1254C>T	c.(1252-1254)CCC>CCT	p.P418P		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	418	Kelch 3.										0																		---	---	---	---
ZFAT	57623	broad.mit.edu	37	8	135596140	135596140	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:135596140A>G	uc003yup.2	-	10	2997	c.2822T>C	c.(2821-2823)ATG>ACG	p.M941T	ZFAT_uc003yun.2_Missense_Mutation_p.M929T|ZFAT_uc003yuo.2_Missense_Mutation_p.M929T|ZFAT_uc010meh.2_Missense_Mutation_p.M929T|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.M929T|ZFAT_uc010mej.2_Missense_Mutation_p.M879T	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	941	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)															---	---	---	---
ZFAT	57623	broad.mit.edu	37	8	135612794	135612794	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:135612794C>T	uc003yup.2	-	7	2535	c.2360G>A	c.(2359-2361)CGC>CAC	p.R787H	ZFAT_uc003yun.2_Missense_Mutation_p.R775H|ZFAT_uc003yuo.2_Missense_Mutation_p.R775H|ZFAT_uc010meh.2_Missense_Mutation_p.R775H|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.R775H|ZFAT_uc010mej.2_Missense_Mutation_p.R725H|ZFAT_uc003yur.2_Missense_Mutation_p.R775H|ZFATAS_uc003yus.1_RNA	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	787	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)															---	---	---	---
ZFAT	57623	broad.mit.edu	37	8	135614222	135614222	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:135614222G>A	uc003yup.2	-	6	1915	c.1740C>T	c.(1738-1740)ACC>ACT	p.T580T	ZFAT_uc003yun.2_Silent_p.T568T|ZFAT_uc003yuo.2_Silent_p.T568T|ZFAT_uc010meh.2_Silent_p.T568T|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.T568T|ZFAT_uc010mej.2_Silent_p.T518T|ZFAT_uc003yur.2_Silent_p.T568T	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	580					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)															---	---	---	---
FAM135B	51059	broad.mit.edu	37	8	139164785	139164785	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139164785T>G	uc003yuy.2	-	13	2104	c.1933A>C	c.(1933-1935)AGT>CGT	p.S645R	FAM135B_uc003yux.2_Missense_Mutation_p.S546R|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.S207R|FAM135B_uc003yvb.2_Missense_Mutation_p.S207R	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	645										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)												HNSCC(54;0.14)			---	---	---	---
COL22A1	169044	broad.mit.edu	37	8	139833475	139833475	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139833475C>T	uc003yvd.2	-	7	1596	c.1149G>A	c.(1147-1149)GCG>GCA	p.A383A		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	383	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)												HNSCC(7;0.00092)			---	---	---	---
SLC45A4	57210	broad.mit.edu	37	8	142221699	142221699	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142221699A>T	uc003ywd.1	-	8	2547	c.2239T>A	c.(2239-2241)TTT>ATT	p.F747I	SLC45A4_uc003ywc.1_3'UTR|SLC45A4_uc010meq.1_Missense_Mutation_p.I747N	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	Error:Variant_position_missing_in_Q5BKX6_after_alignment					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)															---	---	---	---
TSNARE1	203062	broad.mit.edu	37	8	143399948	143399948	+	Missense_Mutation	SNP	C	G	G	rs149572193		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143399948C>G	uc003ywk.2	-	7	1059	c.941G>C	c.(940-942)AGC>ACC	p.S314T	TSNARE1_uc011lju.1_Missense_Mutation_p.S314T|TSNARE1_uc003ywj.2_Missense_Mutation_p.S314T|TSNARE1_uc003ywl.3_Missense_Mutation_p.S95T	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	314					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)																	---	---	---	---
JRK	8629	broad.mit.edu	37	8	143747230	143747230	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143747230G>A	uc003ywo.2	-	2	762	c.248C>T	c.(247-249)ACG>ATG	p.T83M	JRK_uc003ywp.2_Missense_Mutation_p.T83M|JRK_uc010mew.1_Missense_Mutation_p.T83M	NM_001077527	NP_001070995			jerky isoform b												0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)																---	---	---	---
CYP11B1	1584	broad.mit.edu	37	8	143957721	143957721	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143957721G>A	uc003yxi.2	-	5	897	c.890C>T	c.(889-891)GCG>GTG	p.A297V	CYP11B1_uc010mex.2_5'Flank|CYP11B1_uc003yxh.2_5'UTR|CYP11B1_uc003yxj.2_Missense_Mutation_p.A297V|CYP11B1_uc010mey.2_Missense_Mutation_p.A368V	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	297					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)									Familial_Hyperaldosteronism_type_I				---	---	---	---
TOP1MT	116447	broad.mit.edu	37	8	144406745	144406745	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144406745G>A	uc003yxz.2	-	6	745	c.726C>T	c.(724-726)TCC>TCT	p.S242S	TOP1MT_uc011lkd.1_Silent_p.S144S|TOP1MT_uc011lke.1_Silent_p.S144S|TOP1MT_uc010mfb.2_Silent_p.S144S|TOP1MT_uc011lkf.1_Silent_p.S37S|TOP1MT_uc010mfd.1_Silent_p.S37S	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	242					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)													---	---	---	---
FAM83H	286077	broad.mit.edu	37	8	144810854	144810854	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144810854C>T	uc003yzk.2	-	5	846	c.777G>A	c.(775-777)GCG>GCA	p.A259A	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	259					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)															---	---	---	---
EPPK1	83481	broad.mit.edu	37	8	144942069	144942069	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144942069G>A	uc003zaa.1	-	1	5366	c.5353C>T	c.(5353-5355)CGC>TGC	p.R1785C		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1785						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
PLEC	5339	broad.mit.edu	37	8	144993399	144993399	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144993399G>A	uc003zaf.1	-	32	11171	c.11001C>T	c.(10999-11001)TGC>TGT	p.C3667C	PLEC_uc003zab.1_Silent_p.C3530C|PLEC_uc003zac.1_Silent_p.C3534C|PLEC_uc003zad.2_Silent_p.C3530C|PLEC_uc003zae.1_Silent_p.C3498C|PLEC_uc003zag.1_Silent_p.C3508C|PLEC_uc003zah.2_Silent_p.C3516C|PLEC_uc003zaj.2_Silent_p.C3557C	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3667	Globular 2.|Plectin 16.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
GRINA	2907	broad.mit.edu	37	8	145066190	145066190	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145066190G>A	uc003zan.1	+	4	803	c.637G>A	c.(637-639)GTC>ATC	p.V213I	GRINA_uc003zao.1_Missense_Mutation_p.V213I|GRINA_uc003zap.1_Missense_Mutation_p.V213I	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	213	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
GPR172A	79581	broad.mit.edu	37	8	145583773	145583773	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145583773A>G	uc003zcc.1	+	3	778	c.621A>G	c.(619-621)TCA>TCG	p.S207S	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Silent_p.S207S|GPR172A_uc003zce.1_Silent_p.S207S|GPR172A_uc010mfy.1_Silent_p.S207S|GPR172A_uc003zcf.1_Silent_p.S207S|GPR172A_uc011llc.1_Silent_p.S119S	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	207	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)															---	---	---	---
NFKBIL2	4796	broad.mit.edu	37	8	145666225	145666225	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145666225G>A	uc011llg.1	-	9	1055	c.1040C>T	c.(1039-1041)CCG>CTG	p.P347L		NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	347					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)															---	---	---	---
LRRC14	9684	broad.mit.edu	37	8	145746672	145746672	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145746672C>A	uc003zdk.1	+	4	1438	c.1292C>A	c.(1291-1293)CCT>CAT	p.P431H	LRRC14_uc003zdl.1_Missense_Mutation_p.P431H|LRRC14_uc003zdo.2_5'Flank	NM_014665	NP_055480	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	431											0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)															---	---	---	---
ARHGAP39	80728	broad.mit.edu	37	8	145770865	145770865	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145770865T>C	uc003zdt.1	-	7	2844	c.2289A>G	c.(2287-2289)CCA>CCG	p.P763P	ARHGAP39_uc011llk.1_Silent_p.P763P|ARHGAP39_uc003zds.1_Silent_p.P763P	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	763	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0																		---	---	---	---
ARHGAP39	80728	broad.mit.edu	37	8	145773530	145773530	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145773530C>T	uc003zdt.1	-	6	1495	c.940G>A	c.(940-942)GAG>AAG	p.E314K	ARHGAP39_uc011llk.1_Missense_Mutation_p.E314K|ARHGAP39_uc003zds.1_Missense_Mutation_p.E314K	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	314	Pro-rich.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0																		---	---	---	---
ZNF34	80778	broad.mit.edu	37	8	145999295	145999295	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145999295A>G	uc003zdy.3	-	6	1141	c.1039T>C	c.(1039-1041)TAC>CAC	p.Y347H	ZNF34_uc010mgb.2_Missense_Mutation_p.Y244H|ZNF34_uc003zdx.3_Missense_Mutation_p.Y326H	NM_030580	NP_085057	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	347	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)														---	---	---	---
ZNF16	7564	broad.mit.edu	37	8	146156790	146156790	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:146156790G>A	uc003zet.2	-	4	1570	c.1383C>T	c.(1381-1383)CAC>CAT	p.H461H	ZNF16_uc003zeu.2_Silent_p.H461H	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	461	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)														---	---	---	---
ZNF16	7564	broad.mit.edu	37	8	146157713	146157713	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:146157713C>T	uc003zet.2	-	4	647	c.460G>A	c.(460-462)GAC>AAC	p.D154N	ZNF16_uc003zeu.2_Missense_Mutation_p.D154N	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	154					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)														---	---	---	---
DOCK8	81704	broad.mit.edu	37	9	311983	311983	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:311983C>T	uc003zgf.2	+	6	670	c.558C>T	c.(556-558)TGC>TGT	p.C186C	DOCK8_uc011lls.1_Silent_p.C186C|DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Silent_p.C118C|DOCK8_uc010mgt.2_Silent_p.C118C|DOCK8_uc003zgg.2_Silent_p.C118C|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	186					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)														---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2076291	2076291	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2076291C>T	uc003zhc.2	+	13	2097	c.1998C>T	c.(1996-1998)AGC>AGT	p.S666S	SMARCA2_uc003zhd.2_Silent_p.S666S|SMARCA2_uc010mha.2_Silent_p.S657S	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	666					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2170415	2170415	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2170415G>A	uc003zhc.2	+						SMARCA2_uc003zhd.2_Intron|SMARCA2_uc010mha.2_Intron|SMARCA2_uc011llw.1_Intron|SMARCA2_uc003zhf.2_Intron|SMARCA2_uc011llx.1_Intron|SMARCA2_uc003zhe.2_Intron|SMARCA2_uc003zhg.2_Intron|SMARCA2_uc010mhb.2_Intron	NM_003070	NP_003061			SWI/SNF-related matrix-associated						chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
GLIS3	169792	broad.mit.edu	37	9	4118541	4118541	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4118541C>T	uc003zhw.1	-	3	666	c.472G>A	c.(472-474)GGG>AGG	p.G158R	GLIS3_uc003zhx.1_Missense_Mutation_p.G313R|GLIS3_uc003zic.1_Missense_Mutation_p.G313R|GLIS3_uc003zie.1_Missense_Mutation_p.G313R|GLIS3_uc010mhh.1_Missense_Mutation_p.G188R|GLIS3_uc003zid.1_Missense_Mutation_p.G91R|GLIS3_uc010mhi.1_Missense_Mutation_p.G120R|GLIS3_uc003zif.1_Missense_Mutation_p.G91R|GLIS3_uc003zig.1_Missense_Mutation_p.G157R|GLIS3_uc003zih.1_Missense_Mutation_p.G91R|GLIS3_uc003zhy.1_Missense_Mutation_p.G91R|GLIS3_uc003zhz.1_Missense_Mutation_p.G91R|GLIS3_uc003zib.1_Missense_Mutation_p.G157R|GLIS3_uc010mhg.1_Missense_Mutation_p.G91R	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	158					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)														---	---	---	---
JAK2	3717	broad.mit.edu	37	9	5065030	5065030	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5065030G>A	uc010mhm.2	+	8	1317	c.1204G>A	c.(1204-1206)GGC>AGC	p.G402S	JAK2_uc003ziw.2_Missense_Mutation_p.G402S	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	402	SH2; atypical.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				---	---	---	---
RLN1	6013	broad.mit.edu	37	9	5335449	5335449	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5335449C>T	uc003zjb.1	-	2	487	c.360G>A	c.(358-360)AAG>AAA	p.K120K		NM_006911	NP_008842	P04808	REL1_HUMAN	relaxin 1 preproprotein	120					female pregnancy|signal transduction	extracellular region	hormone activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.02)|Lung(218;0.0984)														---	---	---	---
C9orf123	90871	broad.mit.edu	37	9	7798583	7798583	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:7798583C>T	uc003zki.2	-	2	287	c.243G>A	c.(241-243)CCG>CCA	p.P81P	C9orf123_uc003zkj.2_Missense_Mutation_p.R110H			Q96GE9	CI123_HUMAN	Homo sapiens cDNA FLJ46908 fis, clone FEBRA2004867.	78						integral to membrane					0		all_cancers(3;0.0539)|Lung NSC(3;3.36e-05)|all_lung(3;0.000156)|all_epithelial(3;0.0356)		GBM - Glioblastoma multiforme(50;0.0561)														---	---	---	---
PTPRD	5789	broad.mit.edu	37	9	8465548	8465548	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:8465548T>C	uc003zkk.2	-	31	4343	c.3632A>G	c.(3631-3633)TAT>TGT	p.Y1211C	PTPRD_uc003zkp.2_Missense_Mutation_p.Y800C|PTPRD_uc003zkq.2_Missense_Mutation_p.Y800C|PTPRD_uc003zkr.2_Missense_Mutation_p.Y795C|PTPRD_uc003zks.2_Missense_Mutation_p.Y790C|PTPRD_uc003zkl.2_Missense_Mutation_p.Y1202C|PTPRD_uc003zkm.2_Missense_Mutation_p.Y1198C|PTPRD_uc003zkn.2_Missense_Mutation_p.Y800C|PTPRD_uc003zko.2_Missense_Mutation_p.Y797C	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1211	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)											TSP Lung(15;0.13)			---	---	---	---
MPDZ	8777	broad.mit.edu	37	9	13217262	13217262	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:13217262C>A	uc010mia.1	-	8	1175	c.1118G>T	c.(1117-1119)AGT>ATT	p.S373I	MPDZ_uc010mhy.2_Missense_Mutation_p.S373I|MPDZ_uc010mhz.2_Missense_Mutation_p.S373I|MPDZ_uc011lmn.1_Missense_Mutation_p.S373I|MPDZ_uc003zlb.3_Missense_Mutation_p.S373I	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	373					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)														---	---	---	---
C9orf93	203238	broad.mit.edu	37	9	15678851	15678851	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:15678851A>G	uc003zmd.2	+	10	1487	c.1172A>G	c.(1171-1173)TAT>TGT	p.Y391C	C9orf93_uc010mih.1_Missense_Mutation_p.Y391C|C9orf93_uc003zme.2_Missense_Mutation_p.Y298C|C9orf93_uc011lmu.1_Missense_Mutation_p.Y391C	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	391	Potential.										0				GBM - Glioblastoma multiforme(50;4.84e-07)														---	---	---	---
BNC2	54796	broad.mit.edu	37	9	16582983	16582983	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:16582983T>C	uc003zml.2	-	4	571	c.431A>G	c.(430-432)CAT>CGT	p.H144R	BNC2_uc011lmw.1_Missense_Mutation_p.H49R|BNC2_uc003zmm.2_Missense_Mutation_p.H102R|BNC2_uc003zmq.1_Missense_Mutation_p.H158R|BNC2_uc003zmr.1_Missense_Mutation_p.H181R|BNC2_uc003zmp.1_Missense_Mutation_p.H172R|BNC2_uc010mij.1_Missense_Mutation_p.H66R|BNC2_uc003zmu.1_RNA|BNC2_uc010mim.1_RNA|BNC2_uc010min.1_RNA|BNC2_uc003zmo.1_Missense_Mutation_p.H66R|BNC2_uc003zms.1_RNA|BNC2_uc010mik.1_RNA|BNC2_uc010mil.1_RNA|BNC2_uc003zmt.1_RNA	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)														---	---	---	---
DENND4C	55667	broad.mit.edu	37	9	19346646	19346646	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19346646T>G	uc003znq.2	+	18	3057	c.3024T>G	c.(3022-3024)AGT>AGG	p.S1008R	DENND4C_uc011lnc.1_Missense_Mutation_p.S338R|DENND4C_uc011lnd.1_Missense_Mutation_p.S296R|DENND4C_uc003znr.2_Missense_Mutation_p.S296R|DENND4C_uc003zns.2_Missense_Mutation_p.S190R|DENND4C_uc003znt.2_Missense_Mutation_p.S190R	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1008						integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
KIAA1797	54914	broad.mit.edu	37	9	20981690	20981690	+	Intron	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:20981690G>T	uc003zog.1	+						KIAA1797_uc003zoh.1_Intron	NM_017794	NP_060264			hypothetical protein LOC54914							integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)														---	---	---	---
KIAA1797	54914	broad.mit.edu	37	9	20988400	20988400	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:20988400C>T	uc003zog.1	+	43	5339	c.4976C>T	c.(4975-4977)ACA>ATA	p.T1659I	KIAA1797_uc003zoh.1_Missense_Mutation_p.T1095I	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1659						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)														---	---	---	---
LINGO2	158038	broad.mit.edu	37	9	27950586	27950586	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:27950586G>A	uc003zqu.1	-	2	278	c.84C>T	c.(82-84)TGC>TGT	p.C28C	LINGO2_uc010mjf.1_Silent_p.C28C|LINGO2_uc003zqv.1_Silent_p.C28C	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	28	LRRNT.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)														---	---	---	---
TMEM215	401498	broad.mit.edu	37	9	32784413	32784413	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32784413C>T	uc003zri.3	+	2	597	c.232C>T	c.(232-234)CGC>TGC	p.R78C		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	78						integral to membrane					0																		---	---	---	---
KIF24	347240	broad.mit.edu	37	9	34269331	34269331	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34269331T>C	uc003zua.3	-	8	1487	c.1367A>G	c.(1366-1368)GAA>GGA	p.E456G	KIF24_uc010mkb.2_Missense_Mutation_p.E487G	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	456	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)															---	---	---	---
KIAA1161	57462	broad.mit.edu	37	9	34371111	34371111	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34371111G>A	uc003zue.3	-	3	1998	c.1831C>T	c.(1831-1833)CGG>TGG	p.R611W		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	611	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)														---	---	---	---
FBXO10	26267	broad.mit.edu	37	9	37532017	37532017	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37532017C>T	uc004aab.2	-	4	1507	c.1458G>A	c.(1456-1458)GCG>GCA	p.A486A	FBXO10_uc004aac.2_Silent_p.A502A|FBXO10_uc004aad.2_Silent_p.A36A	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	486	PbH1 5.					ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)														---	---	---	---
PGM5	5239	broad.mit.edu	37	9	70993145	70993145	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:70993145A>G	uc004agr.2	+	2	521	c.292A>G	c.(292-294)ATC>GTC	p.I98V		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	98					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2																		---	---	---	---
TMC1	117531	broad.mit.edu	37	9	75420425	75420425	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:75420425A>G	uc004aiz.1	+	18	2234	c.1694A>G	c.(1693-1695)TAT>TGT	p.Y565C	TMC1_uc010moz.1_Missense_Mutation_p.Y523C|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.Y419C|TMC1_uc010mpa.1_Missense_Mutation_p.Y419C	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	565	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1																		---	---	---	---
ALDH1A1	216	broad.mit.edu	37	9	75555148	75555148	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:75555148C>T	uc004ajd.2	-	2	140	c.87G>A	c.(85-87)TGG>TGA	p.W29*	ALDH1A1_uc011lsh.1_5'UTR	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	29					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)													---	---	---	---
C9orf95	54981	broad.mit.edu	37	9	77681726	77681726	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:77681726T>C	uc004aju.2	-	8	1125	c.527A>G	c.(526-528)GAC>GGC	p.D176G	C9orf95_uc004ajs.3_Missense_Mutation_p.D180G|C9orf95_uc004ajr.3_Missense_Mutation_p.D176G|C9orf95_uc004ajt.3_Missense_Mutation_p.D152G	NM_017881	NP_060351	Q9NWW6	NRK1_HUMAN	nicotinamide riboside kinase 1 isoform 1	176					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|ribosylnicotinamide kinase activity				0																		---	---	---	---
PRUNE2	158471	broad.mit.edu	37	9	79322121	79322121	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79322121T>C	uc010mpk.2	-	8	5193	c.5069A>G	c.(5068-5070)GAC>GGC	p.D1690G		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1690					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0																		---	---	---	---
KIF27	55582	broad.mit.edu	37	9	86457221	86457221	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86457221G>A	uc004ana.2	-	17	3796	c.3652C>T	c.(3652-3654)CGG>TGG	p.R1218W	KIF27_uc010mpw.2_Missense_Mutation_p.R1152W|KIF27_uc010mpx.2_Missense_Mutation_p.R1121W	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	1218	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5																		---	---	---	---
SECISBP2	79048	broad.mit.edu	37	9	91965778	91965778	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91965778A>G	uc004aqj.1	+						SECISBP2_uc011ltk.1_Intron|SECISBP2_uc004aqk.1_Intron|SECISBP2_uc010mqo.1_Intron|SECISBP2_uc011ltl.1_Intron	NM_024077	NP_076982			SECIS binding protein 2						translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3																		---	---	---	---
IARS	3376	broad.mit.edu	37	9	95048815	95048815	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95048815T>C	uc004art.1	-						IARS_uc004ars.1_Intron|IARS_uc004aru.3_Intron|IARS_uc010mqr.2_Intron|IARS_uc010mqt.2_Intron	NM_013417	NP_038203			isoleucine tRNA synthetase						isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)													---	---	---	---
BICD2	23299	broad.mit.edu	37	9	95481509	95481509	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95481509C>T	uc004aso.1	-	5	1475	c.1418G>A	c.(1417-1419)CGC>CAC	p.R473H	BICD2_uc004asp.1_Missense_Mutation_p.R473H	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	473	Potential.				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1																		---	---	---	---
ZNF484	83744	broad.mit.edu	37	9	95610559	95610559	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95610559G>T	uc004asu.1	-	5	659	c.510C>A	c.(508-510)TCC>TCA	p.S170S	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Silent_p.S172S|ZNF484_uc010mrb.1_Silent_p.S134S|ZNF484_uc004asv.1_Silent_p.S134S	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
FGD3	89846	broad.mit.edu	37	9	95784667	95784667	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95784667C>G	uc004asw.2	+	14	2181	c.1553C>G	c.(1552-1554)GCA>GGA	p.A518G	FGD3_uc004asx.2_Missense_Mutation_p.A518G|FGD3_uc004asz.2_Missense_Mutation_p.A518G|FGD3_uc011luc.1_Missense_Mutation_p.A121G	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	518					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2																		---	---	---	---
TDRD7	23424	broad.mit.edu	37	9	100245161	100245161	+	Missense_Mutation	SNP	G	A	A	rs142092319	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100245161G>A	uc004axj.2	+	15	2668	c.2443G>A	c.(2443-2445)GCA>ACA	p.A815T	TDRD7_uc011lux.1_Missense_Mutation_p.A741T|TDRD7_uc010msp.1_Missense_Mutation_p.A67T|TDRD7_uc011luy.1_Missense_Mutation_p.A135T	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	815					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)																---	---	---	---
ANKS6	203286	broad.mit.edu	37	9	101552841	101552841	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101552841T>C	uc004ayu.2	-	2	428	c.407A>G	c.(406-408)GAT>GGT	p.D136G	ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	136	ANK 3.									ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)																---	---	---	---
COL15A1	1306	broad.mit.edu	37	9	101787222	101787222	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101787222T>C	uc004azb.1	+	15	2127	c.1921T>C	c.(1921-1923)TTC>CTC	p.F641L		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	641	Triple-helical region 2 (COL2).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)																---	---	---	---
KIAA0368	23392	broad.mit.edu	37	9	114137450	114137450	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114137450G>A	uc004bfe.1	-	39	4587	c.4587C>T	c.(4585-4587)GGC>GGT	p.G1529G		NM_001080398	NP_001073867			KIAA0368 protein												0																		---	---	---	---
KIAA1958	158405	broad.mit.edu	37	9	115421992	115421992	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115421992G>A	uc004bgf.1	+	4	1969	c.1794G>A	c.(1792-1794)ACG>ACA	p.T598T	KIAA1958_uc011lwx.1_Silent_p.T626T	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	598										skin(1)	1																		---	---	---	---
RGS3	5998	broad.mit.edu	37	9	116246469	116246469	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116246469G>A	uc004bhq.2	+	7	786	c.577G>A	c.(577-579)GTT>ATT	p.V193I	RGS3_uc004bhr.2_Missense_Mutation_p.V81I|RGS3_uc004bhs.2_Missense_Mutation_p.V83I	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	193	C2.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
TNC	3371	broad.mit.edu	37	9	117786296	117786296	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117786296G>A	uc004bjj.3	-	27	6813	c.6451C>T	c.(6451-6453)CGT>TGT	p.R2151C	TNC_uc010mvf.2_Missense_Mutation_p.R1878C	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	2151	Fibrinogen C-terminal.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7																		---	---	---	---
ASTN2	23245	broad.mit.edu	37	9	119188284	119188284	+	Missense_Mutation	SNP	C	T	T	rs139072409	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:119188284C>T	uc004bjs.1	-	23	3967	c.3866G>A	c.(3865-3867)CGC>CAC	p.R1289H	ASTN2_uc004bjr.1_Missense_Mutation_p.R1285H|ASTN2_uc004bjt.1_Missense_Mutation_p.R1238H|ASTN2_uc004bjp.1_Missense_Mutation_p.R382H|ASTN2_uc004bjq.1_Missense_Mutation_p.R341H|ASTN2_uc011lxr.1_Missense_Mutation_p.R341H|ASTN2_uc011lxs.1_Missense_Mutation_p.R341H|ASTN2_uc011lxt.1_Missense_Mutation_p.R341H|ASTN2_uc004bjo.1_Missense_Mutation_p.R70H	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1289	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9																		---	---	---	---
OR1L8	138881	broad.mit.edu	37	9	125330568	125330568	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125330568G>C	uc004bmp.1	-	1	189	c.189C>G	c.(187-189)TTC>TTG	p.F63L		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
RABGAP1	23637	broad.mit.edu	37	9	125748541	125748541	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125748541G>A	uc011lzh.1	+	4	567	c.433G>A	c.(433-435)GTA>ATA	p.V145I	RABGAP1_uc004bnl.3_RNA|RABGAP1_uc004bnm.1_Missense_Mutation_p.V145I	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	145	PID.				cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5																		---	---	---	---
CRB2	286204	broad.mit.edu	37	9	126125190	126125190	+	Silent	SNP	C	T	T	rs138658467		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:126125190C>T	uc004bnx.1	+	2	233	c.141C>T	c.(139-141)TGC>TGT	p.C47C	CRB2_uc004bnw.1_Silent_p.C47C	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	47	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1																		---	---	---	---
NR6A1	2649	broad.mit.edu	37	9	127495601	127495601	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127495601A>G	uc004bor.1	-	2	306	c.128T>C	c.(127-129)CTT>CCT	p.L43P	NR6A1_uc004boq.1_Missense_Mutation_p.L43P|NR6A1_uc010mwq.1_Missense_Mutation_p.L43P	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	43					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3																		---	---	---	---
RABEPK	10244	broad.mit.edu	37	9	127994881	127994881	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127994881T>C	uc004bpi.2	+	8	856	c.683T>C	c.(682-684)ATG>ACG	p.M228T	RABEPK_uc004bpj.2_Missense_Mutation_p.M177T|RABEPK_uc004bpk.2_Missense_Mutation_p.M228T|RABEPK_uc004bpl.1_Missense_Mutation_p.M177T|RABEPK_uc004bpm.2_Missense_Mutation_p.M228T	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	228	Kelch 4.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1																		---	---	---	---
ST6GALNAC6	30815	broad.mit.edu	37	9	130656852	130656852	+	Missense_Mutation	SNP	C	T	T	rs139501224	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130656852C>T	uc004bso.1	-	4	355	c.236G>A	c.(235-237)CGA>CAA	p.R79Q	ST6GALNAC6_uc004bsn.1_Missense_Mutation_p.R45Q|ST6GALNAC6_uc011man.1_Missense_Mutation_p.D15N|ST6GALNAC6_uc004bsp.1_Missense_Mutation_p.R79Q|ST6GALNAC6_uc004bsq.1_Missense_Mutation_p.R45Q|ST6GALNAC6_uc004bsr.2_Missense_Mutation_p.R45Q|ST6GALNAC6_uc010mxp.1_RNA	NM_013443	NP_038471	Q969X2	SIA7F_HUMAN	sialytransferase 7F	79	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane|plasma membrane					0																		---	---	---	---
WDR34	89891	broad.mit.edu	37	9	131399202	131399202	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131399202G>A	uc004bvq.1	-	3	664	c.540C>T	c.(538-540)TAC>TAT	p.Y180Y	WDR34_uc004bvs.1_Silent_p.Y171Y|WDR34_uc004bvr.1_Silent_p.Y180Y|WDR34_uc011mbi.1_Silent_p.Y63Y	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	180						cytoplasm				central_nervous_system(2)|skin(1)	3																		---	---	---	---
SET	6418	broad.mit.edu	37	9	131456213	131456213	+	Missense_Mutation	SNP	A	T	T	rs145251942	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131456213A>T	uc004bvt.3	+	7	982	c.741A>T	c.(739-741)GAA>GAT	p.E247D	SET_uc004bvu.3_Missense_Mutation_p.E234D|SET_uc010myg.2_RNA|SET_uc011mbj.1_Missense_Mutation_p.E223D	NM_001122821	NP_001116293	Q01105	SET_HUMAN	SET translocation (myeloid leukemia-associated)	247	Asp/Glu-rich (highly acidic).				DNA replication|mRNA metabolic process|negative regulation of histone acetylation|negative regulation of neuron apoptosis|negative regulation of transcription, DNA-dependent|nucleocytoplasmic transport|nucleosome assembly|nucleosome disassembly	cytosol|endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm|protein complex	histone binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0		Myeloproliferative disorder(178;0.204)		GBM - Glioblastoma multiforme(294;3.1e-09)				T	NUP214	AML								---	---	---	---
SH3GLB2	56904	broad.mit.edu	37	9	131784632	131784632	+	Missense_Mutation	SNP	C	T	T	rs138289691		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131784632C>T	uc004bwv.2	-	2	280	c.134G>A	c.(133-135)CGG>CAG	p.R45Q	SH3GLB2_uc004bww.2_Missense_Mutation_p.R45Q|SH3GLB2_uc004bwx.1_Missense_Mutation_p.R45Q|SH3GLB2_uc011mbm.1_Missense_Mutation_p.R45Q	NM_020145	NP_064530	Q9NR46	SHLB2_HUMAN	SH3-domain GRB2-like endophilin B2	45	BAR.				filopodium assembly|signal transduction	cytoplasm|nucleus	cytoskeletal adaptor activity|SH3 domain binding				0																		---	---	---	---
DOLPP1	57171	broad.mit.edu	37	9	131847046	131847046	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131847046C>T	uc004bxc.2	+	2	204	c.176C>T	c.(175-177)ACG>ATG	p.T59M	DOLPP1_uc004bxd.2_Missense_Mutation_p.T59M|DOLPP1_uc004bxe.2_RNA|DOLPP1_uc004bxf.2_5'Flank	NM_020438	NP_065171	Q86YN1	DOPP1_HUMAN	dolichyl pyrophosphate phosphatase 1 isoform a	59					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			skin(1)	1																		---	---	---	---
ASB6	140459	broad.mit.edu	37	9	132400635	132400635	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132400635T>C	uc004byf.1	-	6	866	c.700A>G	c.(700-702)ATG>GTG	p.M234V	ASB6_uc004bye.1_Missense_Mutation_p.M159V|ASB6_uc004byg.1_Silent_p.R197R|ASB6_uc011mbt.1_Missense_Mutation_p.M155V|ASB6_uc010myx.1_Missense_Mutation_p.M205V	NM_017873	NP_060343	Q9NWX5	ASB6_HUMAN	ankyrin repeat and SOCS box-containing 6 isoform	234	ANK 5.				intracellular signal transduction	cytoplasm					0		Ovarian(14;0.00556)																---	---	---	---
ASS1	445	broad.mit.edu	37	9	133333784	133333784	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133333784G>A	uc004bzm.2	+						ASS1_uc004bzn.2_Intron|ASS1_uc010mza.2_Intron|ASS1_uc004bzo.2_Intron|ASS1_uc010mzb.2_Intron|ASS1_uc004bzp.2_Intron|ASS1_uc010mzc.2_Intron	NM_000050	NP_000041			argininosuccinate synthetase 1						arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)													---	---	---	---
FIBCD1	84929	broad.mit.edu	37	9	133779552	133779552	+	Missense_Mutation	SNP	C	T	T	rs143570837	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133779552C>T	uc004bzz.2	-	7	1530	c.1285G>A	c.(1285-1287)GCC>ACC	p.A429T	FIBCD1_uc011mcc.1_Missense_Mutation_p.A429T	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	429	Fibrinogen C-terminal.|Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)														---	---	---	---
PPAPDC3	84814	broad.mit.edu	37	9	134165480	134165480	+	Silent	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134165480C>G	uc004cal.2	+	1	400	c.96C>G	c.(94-96)GGC>GGG	p.G32G		NM_032728	NP_116117	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain	32	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(1)	1	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)														---	---	---	---
TTF1	7270	broad.mit.edu	37	9	135251548	135251548	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135251548G>A	uc004cbl.2	-	11	2524	c.2472C>T	c.(2470-2472)ATC>ATT	p.I824I	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Silent_p.I309I	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	824					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)														---	---	---	---
DDX31	64794	broad.mit.edu	37	9	135487649	135487649	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135487649G>A	uc004cbq.1	-						DDX31_uc010mzu.1_Intron	NM_022779	NP_073616			DEAD (Asp-Glu-Ala-Asp) box polypeptide 31							nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)														---	---	---	---
GTF3C4	9329	broad.mit.edu	37	9	135553527	135553527	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135553527G>A	uc010mzv.2	+	2	779	c.521G>A	c.(520-522)TGC>TAC	p.C174Y	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	174					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)														---	---	---	---
CEL	1056	broad.mit.edu	37	9	135946427	135946427	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135946427C>T	uc010naa.1	+	11	1563	c.1547C>T	c.(1546-1548)ACG>ATG	p.T516M		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	513					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)														---	---	---	---
ADAMTS13	11093	broad.mit.edu	37	9	136304557	136304557	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136304557C>T	uc004cdv.3	+	15	2220	c.1776C>T	c.(1774-1776)TTC>TTT	p.F592F	ADAMTS13_uc004cdp.3_5'UTR|ADAMTS13_uc004cdt.1_Silent_p.F592F|ADAMTS13_uc004cdu.1_Silent_p.F561F|ADAMTS13_uc004cdw.3_Silent_p.F592F|ADAMTS13_uc004cdx.3_Silent_p.F561F|ADAMTS13_uc004cdy.1_RNA|ADAMTS13_uc004cdz.3_Silent_p.F262F|ADAMTS13_uc004cds.1_Silent_p.F117F|ADAMTS13_uc004cdr.1_RNA	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	592	Spacer.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)														---	---	---	---
TMEM8C	389827	broad.mit.edu	37	9	136389958	136389958	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136389958C>T	uc011mdk.1	-	1	9	c.9G>A	c.(7-9)ACG>ACA	p.T3T		NM_001080483	NP_001073952	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	3						integral to membrane					0																		---	---	---	---
SARDH	1757	broad.mit.edu	37	9	136577755	136577755	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136577755A>G	uc004cep.3	-	10	1448	c.1314T>C	c.(1312-1314)CAT>CAC	p.H438H	SARDH_uc004ceo.2_Silent_p.H438H|SARDH_uc011mdn.1_Silent_p.H438H|SARDH_uc011mdo.1_Silent_p.H270H	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	438					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)														---	---	---	---
COL5A1	1289	broad.mit.edu	37	9	137660308	137660308	+	Missense_Mutation	SNP	C	T	T	rs138259992		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:137660308C>T	uc004cfe.2	+	25	2667	c.2285C>T	c.(2284-2286)CCG>CTG	p.P762L		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	762	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)														---	---	---	---
NOTCH1	4851	broad.mit.edu	37	9	139407849	139407849	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139407849A>G	uc004chz.2	-	14	2348	c.2348T>C	c.(2347-2349)TTC>TCC	p.F783S	NOTCH1_uc004cia.1_Missense_Mutation_p.F13S	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	783	Extracellular (Potential).|EGF-like 20.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)				T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---	---
TPRN	286262	broad.mit.edu	37	9	140087050	140087050	+	Missense_Mutation	SNP	C	G	G	rs77086130		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140087050C>G	uc004clt.2	-	2	1636	c.1636G>C	c.(1636-1638)GAG>CAG	p.E546Q	TPRN_uc004clu.2_Missense_Mutation_p.E546Q	NM_173691	NP_775962	Q4KMQ1	TPRN_HUMAN	hypothetical protein LOC286262 isoform 2	607	Glu-rich.				sensory perception of sound	stereocilium					0																		---	---	---	---
FAM166A	401565	broad.mit.edu	37	9	140138245	140138245	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140138245G>A	uc004cmi.1	-							NM_001001710	NP_001001710			hypothetical protein LOC401565											ovary(1)	1																		---	---	---	---
NELF	26012	broad.mit.edu	37	9	140344457	140344457	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140344457C>T	uc004cna.2	-	14	1569	c.1337G>A	c.(1336-1338)CGC>CAC	p.R446H	C9orf167_uc011mew.1_Intron|NELF_uc011mex.1_Missense_Mutation_p.R243H|NELF_uc010nci.2_Missense_Mutation_p.R190H|NELF_uc011mey.1_RNA|NELF_uc011mez.1_Missense_Mutation_p.R423H|NELF_uc004cmz.2_Missense_Mutation_p.R444H|NELF_uc004cnc.2_Missense_Mutation_p.R421H|NELF_uc004cnb.2_Missense_Mutation_p.R416H	NM_001130969	NP_001124441	Q6X4W1	NELF_HUMAN	nasal embryonic LHRH factor isoform a	446						nucleus|plasma membrane					0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000222)|Epithelial(140;0.000888)														---	---	---	---
CACNA1B	774	broad.mit.edu	37	9	140773593	140773593	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140773593G>A	uc004cog.2	+	2	517	c.372G>A	c.(370-372)ACG>ACA	p.T124T	uc004cof.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	124	I.|Extracellular (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)													---	---	---	---
TUBB8	347688	broad.mit.edu	37	10	93721	93721	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93721T>A	uc001ifi.2	-	4	611	c.611A>T	c.(610-612)AAC>ATC	p.N204I	TUBB8_uc009xhe.2_Missense_Mutation_p.N167I|TUBB8_uc010pzs.1_Missense_Mutation_p.N132I	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	204					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)														---	---	---	---
ANKRD16	54522	broad.mit.edu	37	10	5931081	5931081	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5931081G>T	uc010qat.1	-	1	780	c.237C>A	c.(235-237)GCC>GCA	p.A79A	ANKRD16_uc009xie.2_Silent_p.A79A|ANKRD16_uc009xif.2_Silent_p.A79A|ANKRD16_uc001iiq.2_Silent_p.A79A|FBXO18_uc001iir.2_5'Flank|FBXO18_uc001iis.2_5'Flank|FBXO18_uc009xig.2_5'Flank	NM_019046	NP_061919	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16 isoform a	79	ANK 2.										0																		---	---	---	---
ITIH5	80760	broad.mit.edu	37	10	7618870	7618870	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7618870G>A	uc001ijq.2	-	10	1603	c.1524C>T	c.(1522-1524)AAC>AAT	p.N508N	ITIH5_uc001ijp.2_Silent_p.N294N|ITIH5_uc001ijr.1_Silent_p.N508N	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	508					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
CDNF	441549	broad.mit.edu	37	10	14867588	14867588	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:14867588G>A	uc001inb.1	-	3	313	c.275C>T	c.(274-276)GCC>GTC	p.A92V	CDNF_uc010qbv.1_Missense_Mutation_p.A92V|CDNF_uc001inc.1_5'UTR	NM_001029954	NP_001025125	Q49AH0	CDNF_HUMAN	arginine-rich, mutated in early stage	92						extracellular region	growth factor activity				0																		---	---	---	---
FAM171A1	221061	broad.mit.edu	37	10	15256478	15256478	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15256478G>A	uc001iob.2	-	8	1116	c.1109C>T	c.(1108-1110)GCG>GTG	p.A370V		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	370	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4																		---	---	---	---
MLLT10	8028	broad.mit.edu	37	10	21823702	21823702	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:21823702C>T	uc001iqs.2	+	2	477	c.129C>T	c.(127-129)GAC>GAT	p.D43D	MLLT10_uc001iqt.2_Silent_p.D43D|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Silent_p.D43D|MLLT10_uc001iqr.1_Silent_p.D43D|MLLT10_uc001iqq.1_Silent_p.D43D|MLLT10_uc001iqu.1_Silent_p.D43D|MLLT10_uc009xke.1_RNA|MLLT10_uc001iqw.1_Silent_p.D43D|MLLT10_uc001iqx.1_RNA|MLLT10_uc009xkf.1_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	43	PHD-type 1.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2								T	MLL|PICALM|CDK6	AL								---	---	---	---
ANKRD30A	91074	broad.mit.edu	37	10	37508154	37508154	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:37508154A>G	uc001iza.1	+	34	3445	c.3346A>G	c.(3346-3348)ATA>GTA	p.I1116V		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1172	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9																		---	---	---	---
BMS1	9790	broad.mit.edu	37	10	43287077	43287077	+	Silent	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:43287077T>G	uc001jaj.2	+	6	997	c.639T>G	c.(637-639)GGT>GGG	p.G213G		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	213					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3																		---	---	---	---
BMS1	9790	broad.mit.edu	37	10	43326431	43326431	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:43326431G>A	uc001jaj.2	+	23	4094	c.3736G>A	c.(3736-3738)GAG>AAG	p.E1246K		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	1246					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3																		---	---	---	---
GDF2	2658	broad.mit.edu	37	10	48414360	48414360	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:48414360C>T	uc001jfa.1	-	2	671	c.508G>A	c.(508-510)GTG>ATG	p.V170M		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	170					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3																		---	---	---	---
ERCC6	2074	broad.mit.edu	37	10	50667115	50667115	+	Missense_Mutation	SNP	C	T	T	rs4253229	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50667115C>T	uc001jhs.3	-	21	4382	c.4228G>A	c.(4228-4230)GGG>AGG	p.G1410R	ERCC6_uc009xod.2_Missense_Mutation_p.G570R|ERCC6_uc010qgr.1_Missense_Mutation_p.G780R|ERCC6_uc001jhr.3_Missense_Mutation_p.G778R	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1410	Ubiquitin-binding domain (UBD).				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16													Direct_reversal_of_damage|NER					---	---	---	---
ERCC6	2074	broad.mit.edu	37	10	50682250	50682250	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50682250G>A	uc001jhs.3	-	13	2575	c.2421C>T	c.(2419-2421)AAC>AAT	p.N807N	ERCC6_uc009xod.2_5'UTR|ERCC6_uc010qgr.1_Silent_p.N177N|ERCC6_uc001jhr.3_Silent_p.N175N	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	807					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16													Direct_reversal_of_damage|NER					---	---	---	---
ERCC6	2074	broad.mit.edu	37	10	50686478	50686478	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50686478A>G	uc001jhs.3	-	11	2362	c.2208T>C	c.(2206-2208)GAT>GAC	p.D736D	ERCC6_uc009xod.2_5'Flank|ERCC6_uc010qgr.1_Silent_p.D106D|ERCC6_uc001jhr.3_Silent_p.D136D	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	736					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16													Direct_reversal_of_damage|NER					---	---	---	---
CHAT	1103	broad.mit.edu	37	10	50863468	50863468	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50863468C>T	uc001jhz.2	+	13	1966	c.1813C>T	c.(1813-1815)CGT>TGT	p.R605C	CHAT_uc001jhv.1_Missense_Mutation_p.R487C|CHAT_uc001jhx.1_Missense_Mutation_p.R487C|CHAT_uc001jhy.1_Missense_Mutation_p.R487C|CHAT_uc001jia.2_Missense_Mutation_p.R487C|CHAT_uc010qgs.1_Missense_Mutation_p.R487C	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	605					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)													---	---	---	---
DKK1	22943	broad.mit.edu	37	10	54074806	54074806	+	Missense_Mutation	SNP	C	T	T	rs138015066		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:54074806C>T	uc001jjr.2	+	2	521	c.367C>T	c.(367-369)CGT>TGT	p.R123C	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor	123	DKK-type Cys-1.				negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3																OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ANK3	288	broad.mit.edu	37	10	61941099	61941099	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61941099G>A	uc001jky.2	-	18	2364	c.2172C>T	c.(2170-2172)GAC>GAT	p.D724D	ANK3_uc010qih.1_Silent_p.D707D|ANK3_uc001jkz.3_Silent_p.D718D|ANK3_uc001jlb.1_Silent_p.D253D|ANK3_uc001jlc.1_Silent_p.D385D	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	724	ANK 20.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
HKDC1	80201	broad.mit.edu	37	10	71020998	71020998	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71020998C>T	uc001jpf.3	+	16	2453	c.2320C>T	c.(2320-2322)CGT>TGT	p.R774C	HKDC1_uc010qje.1_Missense_Mutation_p.R637C|HKDC1_uc009xqb.2_RNA	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	774					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5																		---	---	---	---
PSAP	5660	broad.mit.edu	37	10	73577214	73577214	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73577214C>T	uc001jsm.2	-	14	1663	c.1559G>A	c.(1558-1560)CGC>CAC	p.R520H	PSAP_uc001jsl.2_Missense_Mutation_p.R244H	NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	520	Saposin A-type 2.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1																		---	---	---	---
CBARA1	10367	broad.mit.edu	37	10	74135630	74135630	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74135630A>G	uc001jtb.1	-	12	1320	c.1187T>C	c.(1186-1188)GTG>GCG	p.V396A	CBARA1_uc010qjw.1_Missense_Mutation_p.V196A|CBARA1_uc010qjx.1_Missense_Mutation_p.V196A|CBARA1_uc009xqo.1_RNA	NM_006077	NP_006068	Q9BPX6	MICU1_HUMAN	calcium binding atopy-related autoantigen 1	394					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			ovary(1)	1																		---	---	---	---
PPP3CB	5532	broad.mit.edu	37	10	75239068	75239068	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75239068A>G	uc001jue.2	-						PPP3CB_uc001juf.2_Intron|PPP3CB_uc001jug.2_Intron|PPP3CB_uc001jui.2_Intron|PPP3CB_uc001juh.2_Intron	NM_021132	NP_066955			protein phosphatase 3, catalytic subunit, beta											skin(1)	1	Prostate(51;0.0119)																	---	---	---	---
USP54	159195	broad.mit.edu	37	10	75296060	75296060	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75296060A>G	uc001juo.2	-	9	1128	c.1111T>C	c.(1111-1113)TAC>CAC	p.Y371H	USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA|USP54_uc001jup.2_Missense_Mutation_p.Y371H|USP54_uc010qkl.1_Missense_Mutation_p.Y371H|USP54_uc001juq.1_Missense_Mutation_p.Y164H	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	371					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)																	---	---	---	---
ADK	132	broad.mit.edu	37	10	76074474	76074474	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:76074474T>G	uc001jwi.2	+	4	316	c.244T>G	c.(244-246)TCT>GCT	p.S82A	ADK_uc010qlb.1_Missense_Mutation_p.S82A|ADK_uc001jwj.2_Missense_Mutation_p.S65A|ADK_uc010qlc.1_Missense_Mutation_p.S47A	NM_006721	NP_006712	P55263	ADK_HUMAN	adenosine kinase isoform b	82					purine base metabolic process|purine ribonucleoside salvage	cytosol	adenosine kinase activity|ATP binding|metal ion binding|phosphotransferase activity, alcohol group as acceptor			ovary(1)|skin(1)	2	Prostate(51;0.0112)|Ovarian(15;0.148)				Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Pegademase bovine(DB00061)|Ribavirin(DB00811)													---	---	---	---
MYST4	23522	broad.mit.edu	37	10	76784854	76784854	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:76784854C>T	uc001jwn.1	+	17	4004	c.3511C>T	c.(3511-3513)CAG>TAG	p.Q1171*	MYST4_uc001jwo.1_Nonsense_Mutation_p.Q879*|MYST4_uc001jwp.1_Nonsense_Mutation_p.Q988*	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1171					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)							T	CREBBP	AML								---	---	---	---
SAMD8	142891	broad.mit.edu	37	10	76910646	76910646	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:76910646C>T	uc001jwx.1	+	2	463	c.360C>T	c.(358-360)GAC>GAT	p.D120D	SAMD8_uc001jwy.1_Silent_p.D120D	NM_144660	NP_653261	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	120					sphingomyelin biosynthetic process	integral to membrane					0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)																	---	---	---	---
TSPAN14	81619	broad.mit.edu	37	10	82280496	82280496	+	3'UTR	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:82280496C>T	uc001kcj.3	+	9					TSPAN14_uc009xss.2_3'UTR|TSPAN14_uc001kci.3_3'UTR	NM_030927	NP_112189			tetraspanin 14 isoform 1							integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)															---	---	---	---
ACTA2	59	broad.mit.edu	37	10	90699305	90699305	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:90699305C>T	uc001kfp.2	-	7	883	c.767G>A	c.(766-768)CGT>CAT	p.R256H	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Missense_Mutation_p.R211H|ACTA2_uc001kfq.2_Missense_Mutation_p.R256H|uc001kfo.1_RNA	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	256					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)														---	---	---	---
IFIT2	3433	broad.mit.edu	37	10	91066258	91066258	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:91066258G>T	uc009xts.2	+	2	720	c.545G>T	c.(544-546)AGC>ATC	p.S182I	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	182	TPR 3.				negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)																---	---	---	---
KIF20B	9585	broad.mit.edu	37	10	91478615	91478615	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:91478615G>A	uc001kgs.1	+	12	1492	c.1420G>A	c.(1420-1422)GCC>ACC	p.A474T	KIF20B_uc001kgr.1_Missense_Mutation_p.A474T	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	474					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
ANKRD1	27063	broad.mit.edu	37	10	92672639	92672639	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:92672639C>T	uc001khe.1	-	9	1192	c.944G>A	c.(943-945)CGC>CAC	p.R315H		NM_014391	NP_055206	Q15327	ANKR1_HUMAN	cardiac ankyrin repeat protein	315	ANK 5.				cellular lipid metabolic process|defense response|signal transduction		DNA binding				0		Colorectal(252;0.0475)																---	---	---	---
TNKS2	80351	broad.mit.edu	37	10	93596667	93596667	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93596667C>T	uc001khp.2	+							NM_025235	NP_079511			tankyrase, TRF1-interacting ankyrin-related						positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)																---	---	---	---
HHEX	3087	broad.mit.edu	37	10	94452213	94452213	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94452213C>T	uc001kid.2	+	2	513	c.450C>T	c.(448-450)ATC>ATT	p.I150I		NM_002729	NP_002720	Q03014	HHEX_HUMAN	hematopoietically expressed homeobox	150	Homeobox.				anterior/posterior pattern formation|B cell differentiation|cell cycle|DNA conformation change|negative regulation of angiogenesis|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of vascular endothelial growth factor receptor signaling pathway|poly(A)+ mRNA export from nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|Wnt receptor signaling pathway	cytoplasm|nucleus|protein-DNA complex	DNA bending activity|eukaryotic initiation factor 4E binding|protein homodimerization activity|repressing transcription factor binding|sequence-specific DNA binding|TBP-class protein binding|transcription regulatory region DNA binding			ovary(1)	1																		---	---	---	---
MYOF	26509	broad.mit.edu	37	10	95111464	95111464	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95111464A>G	uc001kin.2	-	33	3744	c.3621T>C	c.(3619-3621)AAT>AAC	p.N1207N	MYOF_uc001kio.2_Silent_p.N1194N|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1207	Cytoplasmic (Potential).|C2 4.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4																		---	---	---	---
LGI1	9211	broad.mit.edu	37	10	95518094	95518094	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95518094G>A	uc001kjc.3	+	1	529	c.193G>A	c.(193-195)GTT>ATT	p.V65I	LGI1_uc010qnv.1_Missense_Mutation_p.V65I|LGI1_uc001kjd.3_Missense_Mutation_p.V65I|LGI1_uc009xui.2_RNA|LGI1_uc001kje.2_RNA	NM_005097	NP_005088	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1 precursor	65	LRRNT.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4		Colorectal(252;0.124)																---	---	---	---
CYP2C19	1557	broad.mit.edu	37	10	96540423	96540423	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96540423C>T	uc010qnz.1	+						CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Intron	NM_000769	NP_000760			cytochrome P450, family 2, subfamily C,						exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)													---	---	---	---
SORBS1	10580	broad.mit.edu	37	10	97192201	97192201	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97192201G>A	uc001kkp.2	-						SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Intron|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Intron|SORBS1_uc001kkx.1_Intron	NM_001034954	NP_001030126			sorbin and SH3 domain containing 1 isoform 3						focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)														---	---	---	---
FRAT1	10023	broad.mit.edu	37	10	99079988	99079988	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99079988C>T	uc001knc.1	+	1	967	c.778C>T	c.(778-780)CCT>TCT	p.P260S		NM_005479	NP_005470	Q92837	FRAT1_HUMAN	GSK-3 binding protein FRAT1	260					Wnt receptor signaling pathway	cytoplasm					0		Colorectal(252;0.0846)		Epithelial(162;2.76e-09)|all cancers(201;1.57e-07)														---	---	---	---
COX15	1355	broad.mit.edu	37	10	101486739	101486739	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101486739G>T	uc001kqb.3	-	4	1185	c.568C>A	c.(568-570)CTC>ATC	p.L190I	COX15_uc001kqc.3_Missense_Mutation_p.L190I|COX15_uc010qpj.1_Missense_Mutation_p.L11I	NM_078470	NP_510870	Q7KZN9	COX15_HUMAN	COX15 homolog isoform 1	190	Helical; (Potential).				heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)														---	---	---	---
COX15	1355	broad.mit.edu	37	10	101489383	101489383	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101489383G>A	uc001kqb.3	-	2	816	c.199C>T	c.(199-201)CGG>TGG	p.R67W	COX15_uc001kqc.3_Missense_Mutation_p.R67W|COX15_uc010qpj.1_5'UTR|CUTC_uc010qpk.1_5'Flank|CUTC_uc001kqd.3_5'Flank|CUTC_uc001kqe.3_5'Flank	NM_078470	NP_510870	Q7KZN9	COX15_HUMAN	COX15 homolog isoform 1	67					heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)														---	---	---	---
ABCC2	1244	broad.mit.edu	37	10	101572764	101572764	+	Intron	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101572764C>A	uc001kqf.2	+							NM_000392	NP_000383			ATP-binding cassette, sub-family C (CFTR/MRP),							apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)													---	---	---	---
LBX1	10660	broad.mit.edu	37	10	102987152	102987152	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102987152C>T	uc001ksx.2	-	2	866	c.721G>A	c.(721-723)GCC>ACC	p.A241T	uc010qpy.1_5'Flank	NM_006562	NP_006553	P52954	LBX1_HUMAN	ladybird homeobox 1	241					muscle organ development		sequence-specific DNA binding				0		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)														---	---	---	---
HPS6	79803	broad.mit.edu	37	10	103827571	103827571	+	3'UTR	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103827571G>T	uc001kuj.2	+	1						NM_024747	NP_079023			Hermansky-Pudlak syndrome-6							cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)										Hermansky-Pudlak_syndrome				---	---	---	---
NFKB2	4791	broad.mit.edu	37	10	104160088	104160088	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104160088G>T	uc001kvb.2	+	16	1903	c.1638G>T	c.(1636-1638)CTG>CTT	p.L546L	NFKB2_uc001kva.2_Silent_p.L546L|NFKB2_uc001kvd.2_Silent_p.L546L|NFKB2_uc009xxc.2_Silent_p.L546L	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	546	ANK 2.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)				T	IGH@	B-NHL								---	---	---	---
CNNM2	54805	broad.mit.edu	37	10	104678648	104678648	+	Silent	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104678648C>G	uc001kwm.2	+	1	535	c.411C>G	c.(409-411)GGC>GGG	p.G137G	CNNM2_uc001kwn.2_Silent_p.G137G|CNNM2_uc001kwl.2_Silent_p.G137G	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	137					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)														---	---	---	---
CALHM1	255022	broad.mit.edu	37	10	105215212	105215212	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105215212G>A	uc001kxe.2	-	2	988	c.848C>T	c.(847-849)GCG>GTG	p.A283V	CALHM2_uc001kxd.1_5'Flank	NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	283						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1																		---	---	---	---
COL17A1	1308	broad.mit.edu	37	10	105809853	105809853	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105809853G>T	uc001kxr.2	-	28	2327	c.2158C>A	c.(2158-2160)CTC>ATC	p.L720I	MIR936_hsa-mir-936|MI0005758_5'Flank	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	720	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)														---	---	---	---
SORCS1	114815	broad.mit.edu	37	10	108923852	108923852	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:108923852G>A	uc001kym.2	-	1	441	c.433C>T	c.(433-435)CGG>TGG	p.R145W	SORCS1_uc001kyl.2_Missense_Mutation_p.R145W|SORCS1_uc009xxs.2_Missense_Mutation_p.R145W|SORCS1_uc001kyn.1_Missense_Mutation_p.R145W|SORCS1_uc001kyo.2_Missense_Mutation_p.R145W	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	145	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)														---	---	---	---
ADD3	120	broad.mit.edu	37	10	111878421	111878421	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:111878421C>A	uc001kyt.3	+	7	958	c.644C>A	c.(643-645)CCC>CAC	p.P215H	ADD3_uc001kys.3_Missense_Mutation_p.P215H|ADD3_uc001kyu.2_Missense_Mutation_p.P215H|ADD3_uc001kyv.2_Missense_Mutation_p.P215H|ADD3_uc001kyw.2_Missense_Mutation_p.P215H	NM_016824	NP_058432	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma) isoform a	215						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			ovary(2)|skin(2)|large_intestine(1)	5		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)														---	---	---	---
SMC3	9126	broad.mit.edu	37	10	112338430	112338430	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112338430G>A	uc001kze.2	+	7	521	c.395G>A	c.(394-396)CGA>CAA	p.R132Q		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	132					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)														---	---	---	---
PNLIPRP2	5408	broad.mit.edu	37	10	118404543	118404543	+	Splice_Site	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118404543A>G	uc001lcq.2	+	16	1373	c.1350_splice	c.e16-2	p.E450_splice		NM_005396	NP_005387			pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)														---	---	---	---
KIAA1598	57698	broad.mit.edu	37	10	118700118	118700118	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118700118G>T	uc009xyw.2	-	9	1215	c.717C>A	c.(715-717)TTC>TTA	p.F239L	KIAA1598_uc001lcz.3_Missense_Mutation_p.F239L|KIAA1598_uc010qso.1_Missense_Mutation_p.F179L|KIAA1598_uc010qsp.1_Missense_Mutation_p.F239L|KIAA1598_uc010qsq.1_Missense_Mutation_p.F179L|KIAA1598_uc001lcy.3_Missense_Mutation_p.F209L	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	239	Potential.				axon guidance	axon					0				all cancers(201;0.00494)														---	---	---	---
VAX1	11023	broad.mit.edu	37	10	118896101	118896101	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118896101C>T	uc009xyx.2	-	2	556	c.311G>A	c.(310-312)CGC>CAC	p.R104H	VAX1_uc001ldb.1_Missense_Mutation_p.R104H	NM_001112704	NP_001106175	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1 isoform a	104	Homeobox.					nucleus	sequence-specific DNA binding			ovary(2)	2				all cancers(201;0.0108)														---	---	---	---
EIF3A	8661	broad.mit.edu	37	10	120796733	120796733	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:120796733G>A	uc001ldu.2	-	21	3963	c.3817C>T	c.(3817-3819)CGT>TGT	p.R1273C	EIF3A_uc010qsu.1_Missense_Mutation_p.R1239C	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	1273	Asp-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)														---	---	---	---
RGS10	6001	broad.mit.edu	37	10	121275031	121275031	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121275031A>G	uc001lee.2	-	3	365	c.365T>C	c.(364-366)CTC>CCC	p.L122P	RGS10_uc001lef.2_Missense_Mutation_p.L116P|RGS10_uc001leg.2_Missense_Mutation_p.L130P	NM_002925	NP_002916	O43665	RGS10_HUMAN	regulator of G-protein signaling 10 isoform b	122	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|protein binding|signal transducer activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00105)|GBM - Glioblastoma multiforme(135;0.195)														---	---	---	---
C10orf119	79892	broad.mit.edu	37	10	121618608	121618608	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121618608T>C	uc001ler.2	-	3	528	c.230A>G	c.(229-231)GAC>GGC	p.D77G	C10orf119_uc001les.1_5'UTR	NM_024834	NP_079110	Q9BTE3	MCMBP_HUMAN	chromosome 10 open reading frame 119	77					cell division|DNA-dependent DNA replication|mitosis|S phase of mitotic cell cycle|sister chromatid cohesion	nucleus	chromatin binding				0		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.0044)														---	---	---	---
FGFR2	2263	broad.mit.edu	37	10	123279676	123279676	+	Silent	SNP	C	T	T	rs138769323		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123279676C>T	uc010qtk.1	-	7	1403	c.756G>A	c.(754-756)TCG>TCA	p.S252S	FGFR2_uc010qtg.1_Intron|FGFR2_uc010qth.1_Silent_p.S137S|FGFR2_uc010qti.1_Silent_p.S163S|FGFR2_uc010qtj.1_Silent_p.S252S|FGFR2_uc010qtl.1_Silent_p.S252S|FGFR2_uc010qtm.1_Silent_p.S137S|FGFR2_uc001lfl.3_Silent_p.S252S|FGFR2_uc001lfm.2_Silent_p.S163S|FGFR2_uc001lfn.3_RNA|FGFR2_uc010qtn.1_Silent_p.S271S|FGFR2_uc010qto.1_Silent_p.S156S|FGFR2_uc001lfo.1_Silent_p.S271S|FGFR2_uc010qtp.1_Silent_p.S271S|FGFR2_uc001lfg.3_5'Flank	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	252	Extracellular (Potential).		S -> W (in APRS and PS; common mutation).|S -> F (in APRS; requires 2 nucleotide substitutions).|S -> L (in CS).|SP -> FS (in PS).		angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding	p.S252W(19)		endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				---	---	---	---
TACC2	10579	broad.mit.edu	37	10	123843197	123843197	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123843197C>T	uc001lfv.2	+	4	1542	c.1182C>T	c.(1180-1182)GGC>GGT	p.G394G	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.G394G|TACC2_uc010qtv.1_Silent_p.G394G	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	394						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)																---	---	---	---
C10orf90	118611	broad.mit.edu	37	10	128150089	128150089	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:128150089T>C	uc001ljq.2	-	5	1721	c.1600A>G	c.(1600-1602)ACA>GCA	p.T534A	C10orf90_uc001ljp.2_Missense_Mutation_p.T390A|C10orf90_uc010qum.1_Missense_Mutation_p.T631A|C10orf90_uc001ljo.2_RNA	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	534										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)														---	---	---	---
MKI67	4288	broad.mit.edu	37	10	129903773	129903773	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:129903773T>C	uc001lke.2	-	13	6526	c.6331A>G	c.(6331-6333)ATG>GTG	p.M2111V	MKI67_uc001lkf.2_Missense_Mutation_p.M1751V|MKI67_uc009yav.1_Missense_Mutation_p.M1686V|MKI67_uc009yaw.1_Missense_Mutation_p.M1261V	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2111	16 X 122 AA approximate repeats.|10.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)																---	---	---	---
MKI67	4288	broad.mit.edu	37	10	129904519	129904519	+	Missense_Mutation	SNP	G	A	A	rs138689138		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:129904519G>A	uc001lke.2	-	13	5780	c.5585C>T	c.(5584-5586)CCG>CTG	p.P1862L	MKI67_uc001lkf.2_Missense_Mutation_p.P1502L|MKI67_uc009yav.1_Missense_Mutation_p.P1437L|MKI67_uc009yaw.1_Missense_Mutation_p.P1012L	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1862	16 X 122 AA approximate repeats.|8.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)																---	---	---	---
PPP2R2D	55844	broad.mit.edu	37	10	133747960	133747960	+	5'UTR	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:133747960A>G	uc001lks.2	+	1					PPP2R2D_uc001lkr.2_5'UTR|PPP2R2D_uc001lkt.2_5'UTR	NM_018461	NP_060931			protein phosphatase 2, regulatory subunit B,						cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			skin(1)	1		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)														---	---	---	---
CYP2E1	1571	broad.mit.edu	37	10	135347279	135347279	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135347279G>A	uc001lnj.1	+	6	878	c.845G>A	c.(844-846)CGC>CAC	p.R282H	CYP2E1_uc001lnk.1_Missense_Mutation_p.R145H|CYP2E1_uc009ybl.1_Missense_Mutation_p.R83H|CYP2E1_uc009ybm.1_Intron|CYP2E1_uc001lnl.1_Missense_Mutation_p.R83H	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	282					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				---	---	---	---
FRG2B	441581	broad.mit.edu	37	10	135438851	135438851	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135438851G>T	uc010qvg.1	-	4	642	c.589C>A	c.(589-591)CAG>AAG	p.Q197K		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	197						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)														---	---	---	---
RNH1	6050	broad.mit.edu	37	11	498463	498463	+	Missense_Mutation	SNP	G	A	A	rs150334174	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:498463G>A	uc001lpk.1	-	6	2358	c.950C>T	c.(949-951)TCG>TTG	p.S317L	RNH1_uc001lpl.1_Missense_Mutation_p.S317L|RNH1_uc001lpm.1_Missense_Mutation_p.S317L|RNH1_uc001lpn.1_Missense_Mutation_p.S317L|RNH1_uc001lpo.1_Missense_Mutation_p.S317L|RNH1_uc009ybw.1_RNA|RNH1_uc001lpp.1_Missense_Mutation_p.S317L|RNH1_uc001lpt.1_Missense_Mutation_p.S74L|RNH1_uc001lpq.1_Missense_Mutation_p.S317L|RNH1_uc001lpr.1_Missense_Mutation_p.S317L|RNH1_uc001lps.1_Missense_Mutation_p.S317L	NM_203389	NP_976323	P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor	317	LRR 11.				mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity				0		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
DRD4	1815	broad.mit.edu	37	11	640597	640597	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:640597C>G	uc001lqp.1	+	4	1254	c.1254C>G	c.(1252-1254)TGC>TGG	p.C418W		NM_000797	NP_000788	P21917	DRD4_HUMAN	dopamine receptor D4	466	Cytoplasmic (Potential).				activation of MAPK activity|adult locomotory behavior|arachidonic acid secretion|behavioral fear response|behavioral response to cocaine|behavioral response to ethanol|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of protein secretion|positive regulation of sodium:hydrogen antiporter activity|regulation of dopamine metabolic process|regulation of inhibitory postsynaptic membrane potential|response to amphetamine|response to histamine|social behavior	integral to plasma membrane	dopamine D4 receptor activity|drug binding|potassium channel regulator activity|SH3 domain binding				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.36e-28)|Epithelial(43;2.59e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Apomorphine(DB00714)|Clozapine(DB00363)|Olanzapine(DB00334)|Pramipexole(DB00413)|Promazine(DB00420)|Propiomazine(DB00777)|Ropinirole(DB00268)|Thiethylperazine(DB00372)|Ziprasidone(DB00246)													---	---	---	---
MUC2	4583	broad.mit.edu	37	11	1075884	1075884	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1075884T>C	uc001lsx.1	+	2	337	c.310T>C	c.(310-312)TAC>CAC	p.Y104H		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	104	VWFD 1.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)													---	---	---	---
MUC2	4583	broad.mit.edu	37	11	1082685	1082685	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1082685T>C	uc001lsx.1	+	15	1961	c.1934T>C	c.(1933-1935)ATG>ACG	p.M645T		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	645						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)													---	---	---	---
OR51B4	79339	broad.mit.edu	37	11	5322905	5322905	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5322905G>A	uc010qza.1	-	1	272	c.272C>T	c.(271-273)GCC>GTC	p.A91V	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033179	NP_149419	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
UBQLN3	50613	broad.mit.edu	37	11	5528897	5528897	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5528897C>T	uc001may.1	-	2	1978	c.1892G>A	c.(1891-1893)CGT>CAT	p.R631H	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	631	UBA.							p.R631G(1)		ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
UBQLN3	50613	broad.mit.edu	37	11	5529850	5529850	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5529850T>C	uc001may.1	-	2	1025	c.939A>G	c.(937-939)TCA>TCG	p.S313S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	313										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
CNGA4	1262	broad.mit.edu	37	11	6260711	6260711	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6260711T>G	uc001mco.2	+	2	267	c.160T>G	c.(160-162)TGC>GGC	p.C54G	CNGA4_uc010raa.1_Missense_Mutation_p.C14G|CNGA4_uc001mcn.2_Missense_Mutation_p.C14G	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	54	Helical; Name=H1; (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
SMPD1	6609	broad.mit.edu	37	11	6412983	6412983	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6412983C>T	uc001mcw.2	+	2	862	c.688C>T	c.(688-690)CGC>TGC	p.R230C	SMPD1_uc001mcv.1_Intron|SMPD1_uc009yex.2_RNA|SMPD1_uc001mcx.2_Missense_Mutation_p.R230C|SMPD1_uc009yew.2_Missense_Mutation_p.R229C	NM_000543	NP_000534	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid	228			R -> C (in NPDB).|R -> H (in NPDA/NPDB; intermediate form).		cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)													---	---	---	---
DCHS1	8642	broad.mit.edu	37	11	6646598	6646598	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6646598C>T	uc001mem.1	-	19	7387	c.6977G>A	c.(6976-6978)CGC>CAC	p.R2326H		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2326	Cadherin 22.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
ST5	6764	broad.mit.edu	37	11	8739392	8739392	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8739392G>A	uc001mgt.2	-	5	1711	c.1525C>T	c.(1525-1527)CGA>TGA	p.R509*	ST5_uc009yfr.2_Nonsense_Mutation_p.R89*|ST5_uc001mgu.2_Nonsense_Mutation_p.R89*|ST5_uc001mgv.2_Nonsense_Mutation_p.R509*|ST5_uc010rbq.1_RNA|ST5_uc010rbp.1_Nonsense_Mutation_p.R22*	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	509					positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)														---	---	---	---
DENND5A	23258	broad.mit.edu	37	11	9202415	9202415	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9202415T>C	uc001mhl.2	-	6	1609	c.1354A>G	c.(1354-1356)ATT>GTT	p.I452V	DENND5A_uc010rbw.1_Missense_Mutation_p.I452V|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	452										liver(1)	1																		---	---	---	---
FAR1	84188	broad.mit.edu	37	11	13750163	13750163	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:13750163C>T	uc001mld.2	+	12	1545	c.1390C>T	c.(1390-1392)CGG>TGG	p.R464W		NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	464					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2																		---	---	---	---
SOX6	55553	broad.mit.edu	37	11	16340017	16340017	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:16340017C>A	uc001mme.2	-	3	492	c.459G>T	c.(457-459)GAG>GAT	p.E153D	SOX6_uc001mmd.2_Missense_Mutation_p.E143D|SOX6_uc001mmf.2_Missense_Mutation_p.E140D|SOX6_uc001mmg.2_Missense_Mutation_p.E140D|SOX6_uc001mmh.1_RNA|SOX6_uc009ygs.2_RNA|SOX6_uc001mmi.3_Missense_Mutation_p.E140D|SOX6_uc001mmj.2_Missense_Mutation_p.E140D	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	140					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3																		---	---	---	---
ABCC8	6833	broad.mit.edu	37	11	17414551	17414551	+	Missense_Mutation	SNP	C	T	T	rs143557848		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17414551C>T	uc001mnc.2	-	39	4859	c.4733G>A	c.(4732-4734)CGT>CAT	p.R1578H		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1578	Cytoplasmic (By similarity).|ABC transporter 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)													---	---	---	---
ABCC8	6833	broad.mit.edu	37	11	17418493	17418493	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17418493G>A	uc001mnc.2	-	33	4215	c.4089C>T	c.(4087-4089)CAC>CAT	p.H1363H		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1363	Cytoplasmic (By similarity).|ABC transporter 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)													---	---	---	---
TSG101	7251	broad.mit.edu	37	11	18531139	18531139	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18531139C>T	uc001mor.2	-	5	557	c.431G>A	c.(430-432)CGT>CAT	p.R144H	TSG101_uc001mos.1_Missense_Mutation_p.R92H|TSG101_uc009yhs.1_RNA	NM_006292	NP_006283	Q99816	TS101_HUMAN	tumor susceptibility gene 101	144	UEV.				cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0																		---	---	---	---
NAV2	89797	broad.mit.edu	37	11	20078096	20078096	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20078096G>A	uc010rdm.1	+	21	5282	c.4921G>A	c.(4921-4923)GTG>ATG	p.V1641M	NAV2_uc001mpp.2_Intron|NAV2_uc001mpr.3_Intron|NAV2_uc001mpt.2_Intron|NAV2_uc009yhx.2_Intron|NAV2_uc009yhy.1_Intron|NAV2_uc009yhz.2_Intron|NAV2_uc001mpu.2_Intron	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1641	Ser-rich.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6																		---	---	---	---
LGR4	55366	broad.mit.edu	37	11	27390022	27390022	+	Missense_Mutation	SNP	C	T	T	rs149204548	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:27390022C>T	uc001mrj.3	-	18	2733	c.2248G>A	c.(2248-2250)GCT>ACT	p.A750T	LGR4_uc001mrk.3_Missense_Mutation_p.A726T	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	750	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1																		---	---	---	---
HIPK3	10114	broad.mit.edu	37	11	33308272	33308272	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:33308272G>A	uc001mul.1	+	2	582	c.312G>A	c.(310-312)GTG>GTA	p.V104V	HIPK3_uc001mum.1_Silent_p.V104V|HIPK3_uc009yjv.1_Silent_p.V104V	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	104					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5																		---	---	---	---
LDLRAD3	143458	broad.mit.edu	37	11	36057669	36057669	+	Silent	SNP	C	T	T	rs149080200		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:36057669C>T	uc001mwk.1	+	2	100	c.63C>T	c.(61-63)CCC>CCT	p.P21P	LDLRAD3_uc010rey.1_Intron|LDLRAD3_uc010rez.1_Intron	NM_174902	NP_777562	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain	21	Extracellular (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)																---	---	---	---
HSD17B12	51144	broad.mit.edu	37	11	43876365	43876365	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:43876365C>A	uc001mxq.3	+	10	1020	c.785C>A	c.(784-786)ACA>AAA	p.T262K		NM_016142	NP_057226	Q53GQ0	DHB12_HUMAN	hydroxysteroid (17-beta) dehydrogenase 12	262					long-chain fatty-acyl-CoA biosynthetic process|steroid biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	estradiol 17-beta-dehydrogenase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity				0																		---	---	---	---
ALKBH3	221120	broad.mit.edu	37	11	43918795	43918795	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:43918795G>A	uc001mxs.2	+						ALKBH3_uc009ykp.2_RNA|ALKBH3_uc001mxt.2_RNA|ALKBH3_uc009ykq.2_Intron|LOC729799_uc010rfk.1_5'Flank	NM_139178	NP_631917			AlkB homolog 3						DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation	mitochondrion|nucleoplasm	damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)								Direct_reversal_of_damage					---	---	---	---
ACCS	84680	broad.mit.edu	37	11	44102795	44102795	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:44102795G>A	uc009yks.1	+	12	1180	c.1036G>A	c.(1036-1038)GTG>ATG	p.V346M	EXT2_uc010rfo.1_Intron|ACCS_uc001mxx.2_Missense_Mutation_p.V346M	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase	346							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4																		---	---	---	---
PEX16	9409	broad.mit.edu	37	11	45935754	45935754	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:45935754A>G	uc001nbu.2	-	8	1007	c.695T>C	c.(694-696)TTG>TCG	p.L232S	PEX16_uc001nbt.2_Missense_Mutation_p.L232S	NM_004813	NP_004804	Q9Y5Y5	PEX16_HUMAN	peroxisomal biogenesis factor 16 isoform 1	232	Interaction with PEX19.|Cytoplasmic (Potential).				ER-dependent peroxisome organization|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein import into peroxisome membrane	endoplasmic reticulum membrane|integral to peroxisomal membrane	protein C-terminus binding			ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.223)														---	---	---	---
FNBP4	23360	broad.mit.edu	37	11	47746252	47746252	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47746252A>C	uc009ylv.2	-	13	2240	c.2087T>G	c.(2086-2088)CTT>CGT	p.L696R	FNBP4_uc001ngi.2_Missense_Mutation_p.L10R|FNBP4_uc001ngj.2_Missense_Mutation_p.L603R|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	696										ovary(1)	1																		---	---	---	---
FOLH1	2346	broad.mit.edu	37	11	49190753	49190753	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49190753T>C	uc001ngy.2	-	12	1627	c.1366A>G	c.(1366-1368)ATA>GTA	p.I456V	FOLH1_uc001ngz.2_Missense_Mutation_p.I456V|FOLH1_uc009yly.2_Missense_Mutation_p.I441V|FOLH1_uc009ylz.2_Missense_Mutation_p.I441V|FOLH1_uc009yma.2_Missense_Mutation_p.I148V	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	456	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)													---	---	---	---
FOLH1	2346	broad.mit.edu	37	11	49208219	49208219	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49208219C>T	uc001ngy.2	-	5	877	c.616G>A	c.(616-618)GGG>AGG	p.G206R	FOLH1_uc001ngz.2_Missense_Mutation_p.G206R|FOLH1_uc009yly.2_Missense_Mutation_p.G191R|FOLH1_uc009ylz.2_Missense_Mutation_p.G191R|FOLH1_uc009yma.2_5'UTR	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	206	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)													---	---	---	---
OR10AG1	282770	broad.mit.edu	37	11	55735845	55735845	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55735845C>T	uc010rit.1	-	1	95	c.95G>A	c.(94-96)TGC>TAC	p.C32Y		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)																	---	---	---	---
OR8H3	390152	broad.mit.edu	37	11	55890069	55890069	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55890069A>C	uc001nii.1	+	1	221	c.221A>C	c.(220-222)TAC>TCC	p.Y74S		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)																	---	---	---	---
OR5J2	282775	broad.mit.edu	37	11	55944465	55944465	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55944465G>T	uc010rjb.1	+	1	372	c.372G>T	c.(370-372)GTG>GTT	p.V124V		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)																	---	---	---	---
P2RX3	5024	broad.mit.edu	37	11	57115716	57115716	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57115716C>T	uc001nju.2	+	5	540	c.464C>T	c.(463-465)ACG>ATG	p.T155M		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	155	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0																		---	---	---	---
OR10W1	81341	broad.mit.edu	37	11	58035201	58035201	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58035201T>C	uc001nmq.1	-	1	532	c.130A>G	c.(130-132)ACC>GCC	p.T44A		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	44	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)																---	---	---	---
MS4A12	54860	broad.mit.edu	37	11	60271163	60271163	+	Intron	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60271163A>C	uc001npr.2	+							NM_017716	NP_060186			membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity				0																		---	---	---	---
TMEM132A	54972	broad.mit.edu	37	11	60704345	60704345	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60704345G>A	uc001nqj.2	+	11	3231	c.3038G>A	c.(3037-3039)CGC>CAC	p.R1013H	TMEM132A_uc001nqi.2_Missense_Mutation_p.R1014H|TMEM132A_uc001nqm.2_Missense_Mutation_p.R223H	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	1013	Cytoplasmic (Potential).|Confers cellular localization similar to full-length form (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1																		---	---	---	---
C11orf66	220004	broad.mit.edu	37	11	61257273	61257273	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61257273A>G	uc001nru.1	+	12	1188	c.1063A>G	c.(1063-1065)AAG>GAG	p.K355E	C11orf66_uc009ynq.1_Missense_Mutation_p.K335E	NM_145017	NP_659454	Q7Z5V6	CK066_HUMAN	IIIG9 protein	355										ovary(1)	1																		---	---	---	---
DAGLA	747	broad.mit.edu	37	11	61504660	61504660	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61504660G>A	uc001nsa.2	+	14	1489	c.1378G>A	c.(1378-1380)GGA>AGA	p.G460R		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	460	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)														---	---	---	---
INCENP	3619	broad.mit.edu	37	11	61919240	61919240	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61919240C>T	uc001nsw.1	+	19	2751	c.2549C>T	c.(2548-2550)CCG>CTG	p.P850L	INCENP_uc001nsx.1_Missense_Mutation_p.P846L|INCENP_uc001nsy.1_Missense_Mutation_p.P264L	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	850					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1																		---	---	---	---
AHNAK	79026	broad.mit.edu	37	11	62287437	62287437	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62287437C>T	uc001ntl.2	-	5	14752	c.14452G>A	c.(14452-14454)GTT>ATT	p.V4818I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4818					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)																---	---	---	---
LRRN4CL	221091	broad.mit.edu	37	11	62455710	62455710	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62455710C>A	uc001nun.2	-	2	578	c.271G>T	c.(271-273)GTG>TTG	p.V91L		NM_203422	NP_981967	Q8ND94	LRN4L_HUMAN	LRRN4 C-terminal like precursor	91	Fibronectin type-III.|Extracellular (Potential).					integral to membrane					0																		---	---	---	---
HNRNPUL2	221092	broad.mit.edu	37	11	62483058	62483058	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62483058G>A	uc001nuw.2	-	13	2270	c.2077C>T	c.(2077-2079)CGA>TGA	p.R693*	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	693	Tyr-rich.				cell killing	nucleus	ATP binding|nucleic acid binding				0																		---	---	---	---
SLC3A2	6520	broad.mit.edu	37	11	62653086	62653086	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62653086G>A	uc001nwd.2	+						SLC3A2_uc001nwb.2_Intron|SLC3A2_uc001nwc.2_Intron|SLC3A2_uc001nwe.2_Intron|SLC3A2_uc001nwf.2_Intron|SLC3A2_uc001nwg.2_Intron	NM_002394	NP_002385			solute carrier family 3, member 2 isoform c						blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0																		---	---	---	---
SLC22A6	9356	broad.mit.edu	37	11	62744711	62744711	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62744711G>A	uc001nwk.2	-	9	1817	c.1510C>T	c.(1510-1512)CTG>TTG	p.L504L	SLC22A6_uc001nwl.2_Silent_p.L460L|SLC22A6_uc001nwj.2_Silent_p.L504L|SLC22A6_uc001nwm.2_Silent_p.L460L	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	504	Helical; (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0																		---	---	---	---
MARK2	2011	broad.mit.edu	37	11	63666286	63666286	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63666286C>T	uc001nxw.2	+	6	1034	c.455C>T	c.(454-456)GCT>GTT	p.A152V	MARK2_uc001nxx.2_Missense_Mutation_p.A152V|MARK2_uc001nxy.2_Missense_Mutation_p.A152V|MARK2_uc001nxv.3_Missense_Mutation_p.A152V|MARK2_uc001nxz.3_Missense_Mutation_p.A119V|MARK2_uc009yoy.2_Missense_Mutation_p.A119V	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	152	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3																		---	---	---	---
MARK2	2011	broad.mit.edu	37	11	63669730	63669730	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63669730G>A	uc001nxw.2	+	12	1741	c.1162G>A	c.(1162-1164)GCC>ACC	p.A388T	MARK2_uc001nxx.2_Missense_Mutation_p.A388T|MARK2_uc001nxy.2_Missense_Mutation_p.A388T|MARK2_uc001nxv.3_Missense_Mutation_p.A388T|MARK2_uc001nxz.3_Missense_Mutation_p.A355T|MARK2_uc009yoy.2_Missense_Mutation_p.A355T	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	388					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3																OREG0021038	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MACROD1	28992	broad.mit.edu	37	11	63782731	63782731	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63782731G>A	uc001nyh.2	-	4	659	c.540C>T	c.(538-540)GGC>GGT	p.G180G		NM_014067	NP_054786	Q9BQ69	MACD1_HUMAN	MACRO domain containing 1	180	Macro.										0																		---	---	---	---
GPR137	56834	broad.mit.edu	37	11	64054328	64054328	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64054328C>T	uc001nzg.1	+	2	640	c.332C>T	c.(331-333)ACG>ATG	p.T111M	BAD_uc001nzd.2_5'Flank|BAD_uc001nzc.2_5'Flank|GPR137_uc009ypj.1_Missense_Mutation_p.T117M|BAD_uc009ypk.2_5'Flank|GPR137_uc010rni.1_Missense_Mutation_p.T169M|GPR137_uc001nze.1_Missense_Mutation_p.T111M|GPR137_uc001nzf.2_Missense_Mutation_p.T111M|GPR137_uc001nzh.1_Missense_Mutation_p.T111M|GPR137_uc001nzi.2_Missense_Mutation_p.T111M|GPR137_uc010rnj.1_Missense_Mutation_p.T111M	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	111	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1																		---	---	---	---
CDC42BPG	55561	broad.mit.edu	37	11	64604405	64604405	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64604405C>A	uc001obs.3	-	10	1292	c.1292G>T	c.(1291-1293)AGG>ATG	p.R431M		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	431	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4																		---	---	---	---
ATG2A	23130	broad.mit.edu	37	11	64677365	64677365	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64677365G>A	uc001obx.2	-	14	2010	c.1895C>T	c.(1894-1896)ACG>ATG	p.T632M		NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	632							protein binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
NAALADL1	10004	broad.mit.edu	37	11	64825848	64825848	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64825848A>G	uc001ocn.2	-	1	162	c.146T>C	c.(145-147)ATG>ACG	p.M49T	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	49	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0																		---	---	---	---
MALAT1	378938	broad.mit.edu	37	11	65272957	65272957	+	RNA	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65272957G>C	uc010roh.1	+	1		c.7725G>C			uc001ody.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0																		---	---	---	---
CD248	57124	broad.mit.edu	37	11	66083272	66083272	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66083272G>T	uc001ohm.1	-	1	1244	c.1227C>A	c.(1225-1227)GCC>GCA	p.A409A		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	409	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)													---	---	---	---
PELI3	246330	broad.mit.edu	37	11	66238785	66238785	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66238785C>T	uc001oic.3	+	4	461	c.297C>T	c.(295-297)CAC>CAT	p.H99H	PELI3_uc001oib.2_Silent_p.H99H|PELI3_uc001oid.3_Silent_p.H75H|PELI3_uc001oie.3_Translation_Start_Site|PELI3_uc010rpd.1_5'Flank	NM_145065	NP_659502	Q8N2H9	PELI3_HUMAN	pellino 3 alpha isoform 1	99						cytosol	protein binding			ovary(1)	1																		---	---	---	---
CCS	9973	broad.mit.edu	37	11	66373260	66373260	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66373260G>T	uc001oir.2	+	8	802	c.759G>T	c.(757-759)GAG>GAT	p.E253D	CCS_uc001ois.2_RNA	NM_005125	NP_005116	O14618	CCS_HUMAN	copper chaperone for superoxide dismutase	253					intracellular copper ion transport|oxidation-reduction process|removal of superoxide radicals	cytosol|mitochondrial inner membrane|nucleus|soluble fraction	copper ion transmembrane transporter activity|protein binding|superoxide dismutase copper chaperone activity|zinc ion binding				0																		---	---	---	---
ANKRD13D	338692	broad.mit.edu	37	11	67069033	67069033	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67069033C>T	uc001okc.1	+	14	1673	c.1162C>T	c.(1162-1164)CGC>TGC	p.R388C	ANKRD13D_uc001okd.1_Missense_Mutation_p.R475C|ANKRD13D_uc001oke.1_Missense_Mutation_p.R388C|ANKRD13D_uc001okg.1_Missense_Mutation_p.R171C|ANKRD13D_uc001okh.1_Missense_Mutation_p.R171C|ANKRD13D_uc001oki.1_Missense_Mutation_p.R125C|SSH3_uc001okj.2_5'Flank|SSH3_uc001okk.2_5'Flank|SSH3_uc001okl.2_5'Flank	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	388										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)															---	---	---	---
SSH3	54961	broad.mit.edu	37	11	67075730	67075730	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67075730C>T	uc001okj.2	+	9	1149	c.971C>T	c.(970-972)GCA>GTA	p.A324V	SSH3_uc001okk.2_RNA|SSH3_uc001okl.2_Missense_Mutation_p.A178V	NM_017857	NP_060327	Q8TE77	SSH3_HUMAN	slingshot homolog 3	324					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)															---	---	---	---
PITPNM1	9600	broad.mit.edu	37	11	67267200	67267200	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67267200T>C	uc001olx.2	-	7	1354	c.1165A>G	c.(1165-1167)ACG>GCG	p.T389A	PITPNM1_uc001olw.2_5'Flank|PITPNM1_uc001oly.2_Missense_Mutation_p.T389A|PITPNM1_uc001olz.2_Missense_Mutation_p.T389A	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	389				T->A: No detectable effect on phosphorylation; when associated with A- 793 and A-1222. Strongly reduced phosphorylation; when associated with A- 287. Loss of threonine phosphorylation; when associated with A-287; A-794 and A- 1222.	brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity	p.T389M(1)		lung(2)|central_nervous_system(1)	3																		---	---	---	---
TPCN2	219931	broad.mit.edu	37	11	68840103	68840103	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68840103T>C	uc001oos.2	+	12	1186	c.1070T>C	c.(1069-1071)GTG>GCG	p.V357A	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Missense_Mutation_p.V272A|TPCN2_uc010rqg.1_Missense_Mutation_p.V357A|TPCN2_uc001oot.2_5'Flank	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	357	Cytoplasmic (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)															---	---	---	---
ORAOV1	220064	broad.mit.edu	37	11	69488006	69488006	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:69488006T>C	uc001opc.2	-	2	292	c.134A>G	c.(133-135)CAT>CGT	p.H45R	ORAOV1_uc010rqi.1_Missense_Mutation_p.H45R|ORAOV1_uc009ysm.2_RNA|ORAOV1_uc001opd.2_Intron|ORAOV1_uc001ope.1_Missense_Mutation_p.H45R	NM_153451	NP_703152	Q8WV07	ORAV1_HUMAN	oral cancer overexpressed 1	45											0	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;5.64e-57)|all cancers(3;5.98e-51)|BRCA - Breast invasive adenocarcinoma(2;5.49e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)															---	---	---	---
CTTN	2017	broad.mit.edu	37	11	70282414	70282414	+	3'UTR	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70282414G>A	uc001opv.3	+	18					CTTN_uc001opu.2_Missense_Mutation_p.R602Q|CTTN_uc001opw.3_3'UTR|CTTN_uc001opx.2_3'UTR	NM_005231	NP_005222			cortactin isoform a							cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)														---	---	---	---
SHANK2	22941	broad.mit.edu	37	11	70333142	70333142	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70333142C>T	uc001oqc.2	-	21	3334	c.3256G>A	c.(3256-3258)GTC>ATC	p.V1086I	SHANK2_uc010rqn.1_Missense_Mutation_p.V498I|SHANK2_uc001opz.2_Missense_Mutation_p.V491I|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	707					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)															---	---	---	---
P2RY6	5031	broad.mit.edu	37	11	73007682	73007682	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73007682G>T	uc001otm.2	+	4	524	c.119G>T	c.(118-120)GGC>GTC	p.G40V	P2RY6_uc001otn.2_Missense_Mutation_p.G40V|P2RY6_uc001oto.2_Missense_Mutation_p.G40V|P2RY6_uc001otp.2_Missense_Mutation_p.G40V|P2RY6_uc001otq.2_Missense_Mutation_p.G40V|P2RY6_uc001otr.2_Missense_Mutation_p.G40V|P2RY6_uc001ots.2_Missense_Mutation_p.G40V	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	40	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1																		---	---	---	---
SERPINH1	871	broad.mit.edu	37	11	75282937	75282937	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:75282937G>A	uc001owr.2	+	5	1295	c.1066G>A	c.(1066-1068)GCC>ACC	p.A356T	SERPINH1_uc009yug.2_Missense_Mutation_p.A356T|SERPINH1_uc001ows.2_Missense_Mutation_p.A356T|SERPINH1_uc001owt.2_Missense_Mutation_p.A139T	NM_001235	NP_001226	P50454	SERPH_HUMAN	serine (or cysteine) proteinase inhibitor, clade	356					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			ovary(2)	2	Ovarian(111;0.11)																	---	---	---	---
MAP6	4135	broad.mit.edu	37	11	75298694	75298694	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:75298694C>A	uc001owu.2	-	4	1917	c.1852G>T	c.(1852-1854)GGT>TGT	p.G618C		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	618	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)																	---	---	---	---
INTS4	92105	broad.mit.edu	37	11	77649864	77649864	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77649864C>T	uc001oys.2	-	10	1026	c.998G>A	c.(997-999)CGT>CAT	p.R333H	INTS4_uc001oyt.2_RNA|INTS4_uc001oyu.1_Missense_Mutation_p.R333H	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	333					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)															---	---	---	---
ODZ4	26011	broad.mit.edu	37	11	78440583	78440583	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:78440583G>A	uc001ozl.3	-	22	3707	c.3244C>T	c.(3244-3246)CCG>TCG	p.P1082S		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1082	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4																		---	---	---	---
RAB38	23682	broad.mit.edu	37	11	87883091	87883091	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:87883091A>G	uc001pcj.1	-	2	282	c.235T>C	c.(235-237)TAT>CAT	p.Y79H		NM_022337	NP_071732	P57729	RAB38_HUMAN	RAB38	79					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)																---	---	---	---
CTSC	1075	broad.mit.edu	37	11	88027300	88027300	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:88027300G>A	uc001pck.3	-	7	1367	c.1266C>T	c.(1264-1266)TAC>TAT	p.Y422Y	CTSC_uc001pcl.3_Silent_p.Y274Y	NM_001814	NP_001805	P53634	CATC_HUMAN	cathepsin C isoform a preproprotein	422					immune response	lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92532253	92532253	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92532253A>C	uc001pdj.3	+	9	6091	c.6074A>C	c.(6073-6075)AAG>ACG	p.K2025T		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2025	Extracellular (Potential).|Cadherin 18.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92577560	92577560	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92577560C>T	uc001pdj.3	+	18	11044	c.11027C>T	c.(11026-11028)GCA>GTA	p.A3676V	FAT3_uc001pdi.3_Missense_Mutation_p.A116V	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3676	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
MRE11A	4361	broad.mit.edu	37	11	94180539	94180539	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94180539A>G	uc001peu.2	-	15	1818	c.1629T>C	c.(1627-1629)GAT>GAC	p.D543D	MRE11A_uc001pev.2_Silent_p.D543D|MRE11A_uc009ywj.2_Silent_p.D546D	NM_005591	NP_005582	P49959	MRE11_HUMAN	meiotic recombination 11 homolog A isoform 1	543					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(4)|lung(1)	5		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)											Homologous_recombination	Ataxia-Telangiectasia-Like_Disorder				---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	102992131	102992131	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102992131G>A	uc001pho.2	+	10	1535	c.1391G>A	c.(1390-1392)CGA>CAA	p.R464Q	DYNC2H1_uc001phn.1_Missense_Mutation_p.R464Q|DYNC2H1_uc009yxe.1_Missense_Mutation_p.R464Q	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	464	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	103041640	103041640	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:103041640G>A	uc001pho.2	+	34	5321	c.5177G>A	c.(5176-5178)CGA>CAA	p.R1726Q	DYNC2H1_uc001phn.1_Missense_Mutation_p.R1726Q|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1726	AAA 1 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
NPAT	4863	broad.mit.edu	37	11	108040522	108040522	+	Missense_Mutation	SNP	C	T	T	rs62642487		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108040522C>T	uc001pjz.3	-	15	3061	c.2959G>A	c.(2959-2961)GTC>ATC	p.V987I	NPAT_uc010rvv.1_Missense_Mutation_p.V43I	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	987					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)														---	---	---	---
ATM	472	broad.mit.edu	37	11	108160489	108160489	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108160489G>A	uc001pkb.1	+	29	4782	c.4397G>A	c.(4396-4398)CGA>CAA	p.R1466Q	ATM_uc009yxr.1_Missense_Mutation_p.R1466Q|ATM_uc001pkd.3_Missense_Mutation_p.R118Q|ATM_uc001pke.1_Missense_Mutation_p.R118Q|ATM_uc010rvw.1_Missense_Mutation_p.R118Q|ATM_uc001pkf.2_Missense_Mutation_p.R118Q	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1466					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
KDELC2	143888	broad.mit.edu	37	11	108351905	108351905	+	Splice_Site	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108351905A>G	uc001pkj.2	-	5	1164	c.1098_splice	c.e5+1	p.K366_splice	KDELC2_uc001pki.2_Splice_Site_p.K310_splice	NM_153705	NP_714916			KDEL (Lys-Asp-Glu-Leu) containing 2 precursor							endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)														---	---	---	---
NCAM1	4684	broad.mit.edu	37	11	113126681	113126681	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113126681C>T	uc001pns.2	+	1	83	c.51C>T	c.(49-51)GAC>GAT	p.D17D				P13591	NCAM1_HUMAN	SubName: Full=cDNA FLJ52974, highly similar to Neural cell adhesion molecule 1, 140 kDa isoform;	637	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)														---	---	---	---
TTC12	54970	broad.mit.edu	37	11	113196305	113196305	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113196305C>T	uc001pnu.2	+	6	487	c.382C>T	c.(382-384)CGC>TGC	p.R128C	TTC12_uc001pnv.2_Missense_Mutation_p.R128C|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_5'UTR	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	128	TPR 1.						binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)														---	---	---	---
FXYD6	53826	broad.mit.edu	37	11	117710514	117710514	+	3'UTR	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117710514A>G	uc001pro.1	-	7					FXYD6_uc001prn.1_Intron|FXYD6_uc001prp.1_3'UTR|FXYD6_uc001prq.1_3'UTR|FXYD6_uc001prr.1_3'UTR|FXYD6_uc009yzq.1_3'UTR	NM_022003	NP_071286			FXYD domain-containing ion transport regulator 6							integral to membrane|plasma membrane	ion channel activity			central_nervous_system(1)|skin(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|Breast(348;0.111)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.89e-05)|Epithelial(105;0.00122)														---	---	---	---
MLL	4297	broad.mit.edu	37	11	118375926	118375926	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118375926T>C	uc001pta.2	+	27	9333	c.9310T>C	c.(9310-9312)TTG>CTG	p.L3104L	MLL_uc001ptb.2_Silent_p.L3107L	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3104					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
MLL	4297	broad.mit.edu	37	11	118379858	118379858	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118379858G>A	uc001pta.2	+	29	10857	c.10834G>A	c.(10834-10836)GCT>ACT	p.A3612T	MLL_uc001ptb.2_Missense_Mutation_p.A3615T	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3612					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
TMEM25	84866	broad.mit.edu	37	11	118405304	118405304	+	3'UTR	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118405304C>T	uc010rye.1	+	9					TMEM25_uc001ptk.3_Intron|TMEM25_uc001pth.2_3'UTR|TMEM25_uc009zad.2_3'UTR|TMEM25_uc001pti.2_3'UTR|TMEM25_uc010ryf.1_3'UTR|TMEM25_uc001ptl.2_Intron|TMEM25_uc001ptm.2_Intron|TMEM25_uc001ptn.2_Intron	NM_032780	NP_116169			transmembrane protein 25 isoform 1							extracellular region|integral to membrane|plasma membrane					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)														---	---	---	---
IFT46	56912	broad.mit.edu	37	11	118427698	118427698	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118427698A>G	uc001ptp.1	-	4	486	c.108T>C	c.(106-108)GAT>GAC	p.D36D	IFT46_uc001pto.1_Silent_p.D87D|IFT46_uc009zaf.1_Silent_p.D87D	NM_020153	NP_064538	Q9NQC8	IFT46_HUMAN	IFT46	36	Asp/Glu-rich (highly acidic).				flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding				0																		---	---	---	---
PDZD3	79849	broad.mit.edu	37	11	119057184	119057184	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119057184C>T	uc001pwb.2	+	2	837	c.313C>T	c.(313-315)CCA>TCA	p.P105S	PDZD3_uc001pvy.2_Intron|PDZD3_uc001pvz.2_Intron|PDZD3_uc010rzd.1_Intron|PDZD3_uc001pwa.2_Intron			Q86UT5	NHRF4_HUMAN	RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF4;          Short=NHERF-4; AltName: Full=PDZ domain-containing protein 3; AltName: Full=PDZ domain-containing protein 2; AltName: Full=Intestinal and kidney-enriched PDZ protein; AltName: Full=Sodium-hydrogen exchanger regulatory factor 4;	105					cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)	1	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)														---	---	---	---
ARHGEF12	23365	broad.mit.edu	37	11	120298860	120298860	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120298860G>A	uc001pxl.1	+	8	496	c.489G>A	c.(487-489)CCG>CCA	p.P163P	ARHGEF12_uc009zat.2_Silent_p.P144P|ARHGEF12_uc010rzn.1_Silent_p.P60P|ARHGEF12_uc009zau.1_Silent_p.P60P	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	163					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)				T	MLL	AML								---	---	---	---
TECTA	7007	broad.mit.edu	37	11	121037453	121037453	+	Silent	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:121037453C>A	uc010rzo.1	+	17	5550	c.5550C>A	c.(5548-5550)ATC>ATA	p.I1850I		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1850	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)														---	---	---	---
SORL1	6653	broad.mit.edu	37	11	121460806	121460806	+	Missense_Mutation	SNP	G	A	A	rs148551848	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:121460806G>A	uc001pxx.2	+	30	4216	c.4136G>A	c.(4135-4137)GGC>GAC	p.G1379D	SORL1_uc010rzp.1_Missense_Mutation_p.G225D|SORL1_uc010rzq.1_5'Flank	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1379	Extracellular (Potential).|LDL-receptor class A 8.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)														---	---	---	---
UBASH3B	84959	broad.mit.edu	37	11	122659877	122659877	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122659877A>G	uc001pyi.3	+	6	1201	c.841A>G	c.(841-843)ATC>GTC	p.I281V		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	281	SH3.					cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)														---	---	---	---
ASAM	79827	broad.mit.edu	37	11	122944466	122944466	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122944466G>C	uc001pyt.2	-	7	1197	c.838C>G	c.(838-840)CCA>GCA	p.P280A		NM_024769	NP_079045	Q9H6B4	CLMP_HUMAN	adipocyte-specific adhesion molecule precursor	280	Cytoplasmic (Potential).					integral to membrane|tight junction					0		Breast(109;0.0025)|Lung NSC(97;0.0179)|all_lung(97;0.0182)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.73e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)														---	---	---	---
ZNF202	7753	broad.mit.edu	37	11	123597620	123597620	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123597620T>C	uc001pzd.1	-	9	1432	c.1032A>G	c.(1030-1032)GGA>GGG	p.G344G	ZNF202_uc001pzc.1_Silent_p.G120G|ZNF202_uc001pze.1_Silent_p.G344G|ZNF202_uc001pzf.1_Silent_p.G344G	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	344					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)														---	---	---	---
Unknown	0	broad.mit.edu	37	11	124135342	124135342	+	IGR	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124135342A>G								OR8G2 (39032 upstream) : OR8D1 (44395 downstream)																																			---	---	---	---
ESAM	90952	broad.mit.edu	37	11	124626554	124626554	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124626554G>A	uc001qav.3	-	3	507	c.334C>T	c.(334-336)CGG>TGG	p.R112W	ESAM_uc010sao.1_Intron|ESAM_uc001qau.3_Missense_Mutation_p.R39W|ESAM_uc001qaw.3_RNA|ESAM_uc001qax.3_RNA|ESAM_uc009zbi.2_Missense_Mutation_p.R112W	NM_138961	NP_620411	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule precursor	112	Extracellular (Potential).|Ig-like V-type.				blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction					0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)														---	---	---	---
ROBO3	64221	broad.mit.edu	37	11	124749423	124749423	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124749423C>T	uc001qbc.2	+	25	3940	c.3748C>T	c.(3748-3750)CGG>TGG	p.R1250W	ROBO3_uc001qbd.2_Missense_Mutation_p.R175W|ROBO3_uc010sar.1_Missense_Mutation_p.R299W|ROBO3_uc001qbe.2_Missense_Mutation_p.R175W|ROBO3_uc001qbf.1_Missense_Mutation_p.R134W	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	1250	Cytoplasmic (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)														---	---	---	---
STT3A	3703	broad.mit.edu	37	11	125472242	125472242	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125472242T>C	uc001qcd.2	+	4	304	c.194T>C	c.(193-195)TTT>TCT	p.F65S	STT3A_uc009zbm.2_Missense_Mutation_p.F65S|STT3A_uc001qce.2_Missense_Mutation_p.F65S|STT3A_uc010sbg.1_5'UTR	NM_152713	NP_689926	P46977	STT3A_HUMAN	integral membrane protein 1	65	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)														---	---	---	---
GLB1L2	89944	broad.mit.edu	37	11	134238664	134238664	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134238664T>C	uc001qhp.2	+	10	1204	c.1016T>C	c.(1015-1017)GTC>GCC	p.V339A	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	339					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)														---	---	---	---
WNT5B	81029	broad.mit.edu	37	12	1748923	1748923	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1748923C>T	uc009zdq.2	+	4	644	c.402C>T	c.(400-402)CGC>CGT	p.R134R	WNT5B_uc001qjj.2_Silent_p.R134R|WNT5B_uc001qjk.2_Silent_p.R134R|WNT5B_uc001qjl.2_Silent_p.R134R	NM_032642	NP_116031	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family,	134				R -> S (in Ref. 1; AAG38659).	angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)															---	---	---	---
CACNA2D4	93589	broad.mit.edu	37	12	1983828	1983828	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1983828A>G	uc001qjp.2	-	18	2051	c.1820T>C	c.(1819-1821)ATG>ACG	p.M607T	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Intron	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	607	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)														---	---	---	---
KCNA1	3736	broad.mit.edu	37	12	5021148	5021148	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:5021148G>A	uc001qnh.2	+	2	1709	c.604G>A	c.(604-606)GTC>ATC	p.V202I		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	202					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)													---	---	---	---
ANO2	57101	broad.mit.edu	37	12	5721879	5721879	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:5721879C>T	uc001qnm.2	-	20	2102	c.2030G>A	c.(2029-2031)AGC>AAC	p.S677N		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	682	Extracellular (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7																		---	---	---	---
VWF	7450	broad.mit.edu	37	12	6092336	6092336	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6092336C>T	uc001qnn.1	-	41	7311	c.7061G>A	c.(7060-7062)TGC>TAC	p.C2354Y	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2354					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)													---	---	---	---
NCAPD2	9918	broad.mit.edu	37	12	6640079	6640079	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6640079T>C	uc001qoo.2	+						NCAPD2_uc010sfd.1_Intron	NM_014865	NP_055680			non-SMC condensin I complex, subunit D2						cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5																		---	---	---	---
C12orf53	196500	broad.mit.edu	37	12	6806618	6806618	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6806618G>A	uc001qqf.1	-	3	434	c.358C>T	c.(358-360)CCC>TCC	p.P120S	C12orf53_uc001qqg.1_Missense_Mutation_p.P120S	NM_153685	NP_710152	Q8IYJ0	CL053_HUMAN	hypothetical protein LOC196500 precursor	120	Extracellular (Potential).					integral to membrane					0																		---	---	---	---
CLSTN3	9746	broad.mit.edu	37	12	7293944	7293944	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7293944G>A	uc001qsr.2	+	9	1708	c.1430G>A	c.(1429-1431)GGC>GAC	p.G477D	CLSTN3_uc001qss.2_Missense_Mutation_p.G489D	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	477	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1																OREG0021650	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GDF3	9573	broad.mit.edu	37	12	7842986	7842986	+	Missense_Mutation	SNP	G	A	A	rs112895783	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7842986G>A	uc001qte.2	-	2	619	c.583C>T	c.(583-585)CGG>TGG	p.R195W		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	195			R -> Q (in MCOP7).		eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6																		---	---	---	---
A2M	2	broad.mit.edu	37	12	9264580	9264580	+	Intron	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9264580C>A	uc001qvk.1	-						A2M_uc009zgk.1_Intron	NM_000014	NP_000005			alpha-2-macroglobulin precursor						blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)													---	---	---	---
CLEC1A	51267	broad.mit.edu	37	12	10225945	10225945	+	Silent	SNP	A	C	C	rs34926270		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10225945A>C	uc001qxb.2	-	5	693	c.609T>G	c.(607-609)CCT>CCG	p.P203P	CLEC1A_uc009zhf.2_Silent_p.P115P|CLEC1A_uc001qxc.2_Silent_p.P115P|CLEC1A_uc001qxd.2_Silent_p.P160P|CLEC1A_uc010sgx.1_Silent_p.P101P	NM_016511	NP_057595	Q8NC01	CLC1A_HUMAN	C-type lectin-like receptor-1	203	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
TAS2R30	259293	broad.mit.edu	37	12	11286356	11286356	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:11286356G>C	uc009zhs.1	-	1	488	c.488C>G	c.(487-489)ACT>AGT	p.T163S	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_001097643	NP_001091112			type 2 taste receptor member 30												0																		---	---	---	---
DUSP16	80824	broad.mit.edu	37	12	12629784	12629784	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:12629784T>G	uc001rao.1	-	7	2613	c.1981A>C	c.(1981-1983)ATC>CTC	p.I661L	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.I513L	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	661					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)														---	---	---	---
PLBD1	79887	broad.mit.edu	37	12	14706188	14706188	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14706188T>G	uc001rcc.1	-	2	435	c.274A>C	c.(274-276)ACC>CCC	p.T92P		NM_024829	NP_079105	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	92					lipid catabolic process	extracellular region	hydrolase activity				0																		---	---	---	---
GUCY2C	2984	broad.mit.edu	37	12	14781623	14781623	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14781623G>A	uc001rcd.2	-	20	2343	c.2206C>T	c.(2206-2208)CCA>TCA	p.P736S		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	736	Cytoplasmic (Potential).|Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6																		---	---	---	---
GUCY2C	2984	broad.mit.edu	37	12	14794028	14794028	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14794028G>A	uc001rcd.2	-	18	2193	c.2056C>T	c.(2056-2058)CGG>TGG	p.R686W		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	686	Cytoplasmic (Potential).|Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6																		---	---	---	---
KIAA0528	9847	broad.mit.edu	37	12	22624384	22624384	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22624384G>T	uc001rfq.2	-	20	2535	c.2307C>A	c.(2305-2307)TGC>TGA	p.C769*	KIAA0528_uc010sir.1_Nonsense_Mutation_p.C584*|KIAA0528_uc010sis.1_Nonsense_Mutation_p.C769*|KIAA0528_uc010sit.1_Nonsense_Mutation_p.C771*|KIAA0528_uc010siu.1_Nonsense_Mutation_p.C769*|KIAA0528_uc001rfr.2_Nonsense_Mutation_p.C760*	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	769							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
KIAA0528	9847	broad.mit.edu	37	12	22677399	22677399	+	Intron	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22677399T>A	uc001rfq.2	-						KIAA0528_uc010sir.1_Intron|KIAA0528_uc010sis.1_Intron|KIAA0528_uc010sit.1_Intron|KIAA0528_uc010siu.1_Intron|KIAA0528_uc001rfr.2_Intron|KIAA0528_uc009ziy.1_Intron	NM_014802	NP_055617			hypothetical protein LOC9847								protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
ITPR2	3709	broad.mit.edu	37	12	26572039	26572039	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:26572039C>T	uc001rhg.2	-	50	7470	c.7053G>A	c.(7051-7053)GCG>GCA	p.A2351A	ITPR2_uc009zjg.1_Silent_p.A502A	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2351	Extracellular (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)																	---	---	---	---
KLHDC5	57542	broad.mit.edu	37	12	27950767	27950767	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27950767G>A	uc001rij.2	+	3	1263	c.1186G>A	c.(1186-1188)GTG>ATG	p.V396M	KLHDC5_uc009zjj.2_RNA	NM_020782	NP_065833	Q9P2K6	KLDC5_HUMAN	kelch domain containing 5	396	Kelch 5.									ovary(1)|central_nervous_system(1)	2	Lung SC(9;0.0873)																	---	---	---	---
PTHLH	5744	broad.mit.edu	37	12	28122392	28122392	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:28122392C>T	uc001rik.2	-	2	339	c.36G>A	c.(34-36)GCG>GCA	p.A12A	PTHLH_uc001ril.2_Silent_p.A12A|PTHLH_uc001rim.2_Silent_p.A12A|PTHLH_uc001rin.2_Silent_p.A12A	NM_198966	NP_945317	P12272	PTHR_HUMAN	parathyroid hormone-like hormone isoform 1	12					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)	1	Lung SC(9;0.184)																	---	---	---	---
IPO8	10526	broad.mit.edu	37	12	30784848	30784848	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:30784848C>T	uc001rjd.2	-	24	3167	c.2997G>A	c.(2995-2997)GAG>GAA	p.E999E	IPO8_uc001rje.1_Silent_p.E488E|IPO8_uc010sjt.1_Silent_p.E794E	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	999					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)																	---	---	---	---
LRRK2	120892	broad.mit.edu	37	12	40717061	40717061	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40717061T>C	uc001rmg.3	+	38	5730	c.5609T>C	c.(5608-5610)TTG>TCG	p.L1870S	LRRK2_uc009zjw.2_Missense_Mutation_p.L708S|LRRK2_uc001rmi.2_Missense_Mutation_p.L703S	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1870			L -> F.		activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)																---	---	---	---
NELL2	4753	broad.mit.edu	37	12	45269072	45269072	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:45269072C>T	uc001rog.2	-	2	715	c.120G>A	c.(118-120)GAG>GAA	p.E40E	NELL2_uc001rof.3_Silent_p.E39E|NELL2_uc001roh.2_Silent_p.E40E|NELL2_uc009zkd.2_Silent_p.E39E|NELL2_uc010skz.1_Silent_p.E90E|NELL2_uc010sla.1_Silent_p.E63E|NELL2_uc001roi.1_Silent_p.E40E|NELL2_uc010slb.1_Silent_p.E39E|NELL2_uc001roj.2_Silent_p.E40E	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	40	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)														---	---	---	---
SENP1	29843	broad.mit.edu	37	12	48477525	48477525	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48477525G>A	uc001rqx.2	-	6	847	c.401C>T	c.(400-402)GCG>GTG	p.A134V	SENP1_uc001rqw.2_Missense_Mutation_p.A134V|SENP1_uc001rqy.2_5'UTR|SENP1_uc001rqz.2_5'UTR|SENP1_uc009zkx.2_Missense_Mutation_p.A134V	NM_014554	NP_055369	Q9P0U3	SENP1_HUMAN	sentrin/SUMO-specific protease 1	134	Ser-rich.				activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			pancreas(2)|lung(1)	3		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)																---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49445038	49445038	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49445038T>C	uc001rta.3	-	10	2428	c.2428A>G	c.(2428-2430)ACT>GCT	p.T810A		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	810	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
KCNH3	23416	broad.mit.edu	37	12	49948198	49948198	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49948198C>T	uc001ruh.1	+	11	2257	c.1997C>T	c.(1996-1998)ACG>ATG	p.T666M	KCNH3_uc010smj.1_Missense_Mutation_p.T606M	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	666	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0																		---	---	---	---
AQP6	363	broad.mit.edu	37	12	50369275	50369275	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:50369275G>A	uc001rvr.1	+	4	1007	c.670G>A	c.(670-672)GCC>ACC	p.A224T	AQP6_uc001rvp.1_Missense_Mutation_p.A50T|AQP6_uc001rvq.1_RNA	NM_001652	NP_001643	Q13520	AQP6_HUMAN	aquaporin 6	224	Helical; (Potential).				excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity				0																		---	---	---	---
DIP2B	57609	broad.mit.edu	37	12	51054033	51054033	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51054033G>A	uc001rwv.2	+	4	514	c.358G>A	c.(358-360)GCT>ACT	p.A120T	DIP2B_uc001rwu.2_Missense_Mutation_p.A120T|DIP2B_uc009zls.1_Missense_Mutation_p.A2T	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	120						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6																		---	---	---	---
KRT73	319101	broad.mit.edu	37	12	53009982	53009982	+	Silent	SNP	G	A	A	rs116369374	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53009982G>A	uc001sas.2	-	2	665	c.630C>T	c.(628-630)AGC>AGT	p.S210S		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	210	Coil 1B.|Rod.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)														---	---	---	---
KRT3	3850	broad.mit.edu	37	12	53189265	53189265	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53189265C>T	uc001say.2	-	1	628	c.562G>A	c.(562-564)GAC>AAC	p.D188N		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	188	Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0																		---	---	---	---
TENC1	23371	broad.mit.edu	37	12	53448186	53448186	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53448186G>A	uc001sbp.2	+	7	618	c.483G>A	c.(481-483)CTG>CTA	p.L161L	uc001sbk.1_RNA|TENC1_uc001sbl.2_Silent_p.L37L|TENC1_uc001sbm.2_Silent_p.L171L|TENC1_uc001sbn.2_Silent_p.L171L|TENC1_uc001sbo.1_Silent_p.L161L	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	161	Phosphatase tensin-type.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2																		---	---	---	---
ITGB7	3695	broad.mit.edu	37	12	53586138	53586138	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53586138C>T	uc009zmv.2	-	13	2202	c.2131G>A	c.(2131-2133)GTG>ATG	p.V711M	ITGB7_uc001scc.2_Missense_Mutation_p.V711M|ITGB7_uc010snz.1_RNA	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	711	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8																		---	---	---	---
ESPL1	9700	broad.mit.edu	37	12	53679949	53679949	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53679949A>G	uc001sck.2	+	18	3520	c.3429A>G	c.(3427-3429)TCA>TCG	p.S1143S	ESPL1_uc001scj.2_Silent_p.S818S|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1143					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3																		---	---	---	---
AMHR2	269	broad.mit.edu	37	12	53818998	53818998	+	Silent	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53818998C>G	uc001scx.1	+	4	552	c.474C>G	c.(472-474)CTC>CTG	p.L158L	AMHR2_uc009zmy.1_Silent_p.L158L	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	158	Helical; (Potential).				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				---	---	---	---
HOXC13	3229	broad.mit.edu	37	12	54338951	54338951	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54338951C>T	uc001sei.2	+	2	1019	c.904C>T	c.(904-906)CGC>TGC	p.R302C	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	302	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1								T	NUP98	AML								---	---	---	---
HOXC10	3226	broad.mit.edu	37	12	54379398	54379398	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54379398C>T	uc001sen.2	+	1	453	c.355C>T	c.(355-357)CGG>TGG	p.R119W		NM_017409	NP_059105	Q9NYD6	HXC10_HUMAN	homeobox C10	119					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1																		---	---	---	---
HOXC5	3222	broad.mit.edu	37	12	54427288	54427288	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54427288C>T	uc001sew.2	+	1	457	c.382C>T	c.(382-384)CCC>TCC	p.P128S	HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron|MIR615_hsa-mir-615|MI0003628_5'Flank	NM_018953	NP_061826	Q00444	HXC5_HUMAN	homeobox C5	128					regulation of transcription from RNA polymerase II promoter	cell junction|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
HOXC5	3222	broad.mit.edu	37	12	54428259	54428259	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54428259A>G	uc001sew.2	+	2	727	c.652A>G	c.(652-654)AGC>GGC	p.S218G	HOXC5_uc001set.2_RNA|HOXC4_uc001seu.2_Intron	NM_018953	NP_061826	Q00444	HXC5_HUMAN	homeobox C5	218					regulation of transcription from RNA polymerase II promoter	cell junction|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
SMUG1	23583	broad.mit.edu	37	12	54576034	54576034	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54576034C>T	uc001sff.1	-	4	788	c.659G>A	c.(658-660)CGG>CAG	p.R220Q	SMUG1_uc001sfa.1_RNA|SMUG1_uc001sfe.1_3'UTR|SMUG1_uc001sfg.1_Missense_Mutation_p.R220Q|SMUG1_uc009znf.1_Missense_Mutation_p.R220Q|SMUG1_uc001sfb.3_Intron|SMUG1_uc001sfc.3_Intron|SMUG1_uc001sfd.3_Intron	NM_014311	NP_055126	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional	220					depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity				0													BER_DNA_glycosylases					---	---	---	---
ERBB3	2065	broad.mit.edu	37	12	56494032	56494032	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56494032A>G	uc001sjh.2	+						ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Intron|ERBB3_uc009zok.2_Intron|ERBB3_uc001sjk.2_Intron|ERBB3_uc001sjl.2_Intron	NM_001982	NP_001973			erbB-3 isoform 1 precursor						cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)															---	---	---	---
SLC39A5	283375	broad.mit.edu	37	12	56629008	56629008	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56629008G>A	uc010sqj.1	+	7	959	c.702G>A	c.(700-702)CTG>CTA	p.L234L	SLC39A5_uc010sqi.1_Silent_p.L125L|SLC39A5_uc010sqk.1_Silent_p.L234L	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	234	Cytoplasmic (Potential).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2																		---	---	---	---
SLC39A5	283375	broad.mit.edu	37	12	56630979	56630979	+	Missense_Mutation	SNP	T	G	G	rs145213363		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56630979T>G	uc010sqj.1	+	12	1591	c.1334T>G	c.(1333-1335)CTG>CGG	p.L445R	SLC39A5_uc010sqk.1_Missense_Mutation_p.L445R	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	445	Helical; (Potential).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2																		---	---	---	---
ANKRD52	283373	broad.mit.edu	37	12	56639302	56639302	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56639302G>A	uc001skm.3	-	21	2353	c.2263C>T	c.(2263-2265)CGC>TGC	p.R755C		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	755	ANK 22.						protein binding			ovary(2)	2																		---	---	---	---
APOF	319	broad.mit.edu	37	12	56755073	56755073	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56755073T>C	uc001sle.1	-	2	971	c.917A>G	c.(916-918)TAC>TGC	p.Y306C		NM_001638	NP_001629	Q13790	APOF_HUMAN	apolipoprotein F precursor	306					cholesterol metabolic process	high-density lipoprotein particle|low-density lipoprotein particle	cholesterol binding|lipid transporter activity|receptor binding				0																		---	---	---	---
NACA	4666	broad.mit.edu	37	12	57111304	57111304	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57111304G>A	uc001slz.2	-						NACA_uc001sly.2_Intron|NACA_uc009zoy.1_Missense_Mutation_p.A1337V|NACA_uc001smc.2_Intron|NACA_uc001sma.2_Intron|NACA_uc001smb.2_Intron|NACA_uc010squ.1_Intron	NM_001113201	NP_001106672			nascent polypeptide-associated complex alpha						interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1								T	BCL6	NHL								---	---	---	---
NACA	4666	broad.mit.edu	37	12	57111308	57111308	+	Intron	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57111308G>C	uc001slz.2	-						NACA_uc001sly.2_Intron|NACA_uc009zoy.1_Missense_Mutation_p.P1336A|NACA_uc001smc.2_Intron|NACA_uc001sma.2_Intron|NACA_uc001smb.2_Intron|NACA_uc010squ.1_Intron	NM_001113201	NP_001106672			nascent polypeptide-associated complex alpha						interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1								T	BCL6	NHL								---	---	---	---
LRP1	4035	broad.mit.edu	37	12	57567028	57567028	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57567028C>T	uc001snd.2	+	21	3707	c.3241C>T	c.(3241-3243)CGC>TGC	p.R1081C		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1081	Extracellular (Potential).|LDL-receptor class A 8.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)											OREG0021936	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
LRIG3	121227	broad.mit.edu	37	12	59279691	59279691	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:59279691A>G	uc001sqr.2	-						LRIG3_uc009zqh.2_Intron|LRIG3_uc010ssh.1_Intron	NM_153377	NP_700356			leucine-rich repeats and immunoglobulin-like							integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)															---	---	---	---
DPY19L2	283417	broad.mit.edu	37	12	63976277	63976277	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:63976277A>G	uc001srp.1	-	18	1815	c.1634T>C	c.(1633-1635)GTG>GCG	p.V545A	DPY19L2_uc010sso.1_5'UTR	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	545	Helical; (Potential).				multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)														---	---	---	---
DPY19L2	283417	broad.mit.edu	37	12	64061905	64061905	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64061905G>A	uc001srp.1	-	1	450	c.269C>T	c.(268-270)GCG>GTG	p.A90V	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	90					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)														---	---	---	---
GNS	2799	broad.mit.edu	37	12	65110520	65110520	+	3'UTR	SNP	G	A	A	rs113381844		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:65110520G>A	uc001ssg.3	-	14					GNS_uc001ssf.2_3'UTR|GNS_uc010ssq.1_3'UTR|GNS_uc010ssr.1_3'UTR	NM_002076	NP_002067			glucosamine (N-acetyl)-6-sulfatase precursor							lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)														---	---	---	---
GRIP1	23426	broad.mit.edu	37	12	66990656	66990656	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66990656G>A	uc001stk.2	-	2	348	c.107C>T	c.(106-108)GCG>GTG	p.A36V	GRIP1_uc010sta.1_Intron|GRIP1_uc001stm.2_Missense_Mutation_p.A36V	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	36					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)														---	---	---	---
CAND1	55832	broad.mit.edu	37	12	67706561	67706561	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:67706561T>C	uc001stn.2	+	15	4081	c.3644T>C	c.(3643-3645)ATC>ACC	p.I1215T	CAND1_uc001sto.2_Missense_Mutation_p.I725T	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	1215					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)														---	---	---	---
YEATS4	8089	broad.mit.edu	37	12	69753804	69753804	+	Splice_Site	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69753804G>A	uc001sux.2	+	1	272	c.51_splice	c.e1+1	p.K17_splice		NM_006530	NP_006521			glioma-amplified sequence-41						histone H2A acetylation|histone H4 acetylation|mitosis|positive regulation of transcription, DNA-dependent|regulation of growth	NuA4 histone acetyltransferase complex|nuclear matrix	DNA binding|protein C-terminus binding|sequence-specific DNA binding transcription factor activity|structural constituent of cytoskeleton				0	all_epithelial(5;9.25e-35)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;6.89e-18)|BRCA - Breast invasive adenocarcinoma(5;3.14e-09)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)															---	---	---	---
TRHDE	29953	broad.mit.edu	37	12	73050744	73050744	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:73050744A>G	uc001sxa.2	+	18	2917	c.2887A>G	c.(2887-2889)AGT>GGT	p.S963G		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	963	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
NAV3	89795	broad.mit.edu	37	12	78569092	78569092	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:78569092G>A	uc001syp.2	+	25	5161	c.4988G>A	c.(4987-4989)CGC>CAC	p.R1663H	NAV3_uc001syo.2_Missense_Mutation_p.R1663H|NAV3_uc010sub.1_Missense_Mutation_p.R1149H|NAV3_uc009zsf.2_Missense_Mutation_p.R494H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1663						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17															HNSCC(70;0.22)			---	---	---	---
TMTC2	160335	broad.mit.edu	37	12	83379836	83379836	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:83379836G>A	uc001szt.2	+						TMTC2_uc001szs.1_Missense_Mutation_p.R694H|TMTC2_uc010suk.1_Intron	NM_152588	NP_689801			transmembrane and tetratricopeptide repeat							endoplasmic reticulum|integral to membrane	binding			ovary(2)	2																		---	---	---	---
TMTC2	160335	broad.mit.edu	37	12	83455558	83455558	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:83455558T>C	uc001szt.2	+	11	2711	c.2279T>C	c.(2278-2280)CTC>CCC	p.L760P	TMTC2_uc010suk.1_Missense_Mutation_p.L515P	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	760	TPR 9.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2																		---	---	---	---
POC1B	282809	broad.mit.edu	37	12	89864258	89864258	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:89864258T>C	uc001tbc.2	-	7	795	c.690A>G	c.(688-690)GGA>GGG	p.G230G	POC1B_uc001tba.2_Silent_p.G188G|POC1B_uc001tbb.2_Silent_p.G100G|POC1B_uc010sun.1_RNA|POC1B_uc009zsp.2_RNA|POC1B_uc009zsq.2_Intron	NM_172240	NP_758440	Q8TC44	POC1B_HUMAN	WD repeat domain 51B	230	WD 6.				cell projection organization	centriole|microtubule basal body				ovary(1)	1																		---	---	---	---
NR2C1	7181	broad.mit.edu	37	12	95443007	95443007	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95443007G>A	uc001tdm.3	-	9	1224	c.968C>T	c.(967-969)GCA>GTA	p.A323V	NR2C1_uc010suu.1_Missense_Mutation_p.A323V|NR2C1_uc001tdo.3_Missense_Mutation_p.A323V|NR2C1_uc001tdn.3_Missense_Mutation_p.A323V	NM_003297	NP_003288	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	323					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
FGD6	55785	broad.mit.edu	37	12	95604038	95604038	+	Missense_Mutation	SNP	G	A	A	rs150209312		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95604038G>A	uc001tdp.3	-	2	1246	c.1022C>T	c.(1021-1023)CCG>CTG	p.P341L	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	341					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3																		---	---	---	---
AMDHD1	144193	broad.mit.edu	37	12	96350720	96350720	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96350720C>T	uc001tel.1	+	4	673	c.567C>T	c.(565-567)TGC>TGT	p.C189C	AMDHD1_uc009zth.1_Silent_p.C80C	NM_152435	NP_689648	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	189					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)	1																		---	---	---	---
ELK3	2004	broad.mit.edu	37	12	96641215	96641215	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96641215C>T	uc001teo.1	+	3	984	c.705C>T	c.(703-705)TCC>TCT	p.S235S		NM_005230	NP_005221	P41970	ELK3_HUMAN	ELK3 protein	235					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	all_cancers(2;0.00173)																	---	---	---	---
IGF1	3479	broad.mit.edu	37	12	102813396	102813396	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:102813396C>T	uc001tjp.3	-	3	512	c.293G>A	c.(292-294)CGG>CAG	p.R98Q	IGF1_uc001tjn.2_Missense_Mutation_p.R82Q|IGF1_uc001tjm.2_Missense_Mutation_p.R98Q|IGF1_uc001tjo.2_Missense_Mutation_p.R98Q	NM_001111285	NP_001104755	P05019	IGF1_HUMAN	insulin-like growth factor 1 isoform 3	98	A.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
KIAA1033	23325	broad.mit.edu	37	12	105540906	105540906	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:105540906G>A	uc001tld.2	+	24	2583	c.2496G>A	c.(2494-2496)ACG>ACA	p.T832T	KIAA1033_uc010swr.1_Silent_p.T833T|KIAA1033_uc010sws.1_Silent_p.T644T	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	832					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2																		---	---	---	---
ASCL4	121549	broad.mit.edu	37	12	108169016	108169016	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:108169016G>A	uc001tmr.2	+	1	855	c.24G>A	c.(22-24)GCG>GCA	p.A8A		NM_203436	NP_982260	Q6XD76	ASCL4_HUMAN	achaete-scute complex-like 4	7					regulation of transcription from RNA polymerase II promoter|skin development|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)	1																		---	---	---	---
SELPLG	6404	broad.mit.edu	37	12	109017999	109017999	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109017999C>T	uc001tni.2	-	2	245	c.85G>A	c.(85-87)GAG>AAG	p.E29K	SELPLG_uc001tnh.2_Missense_Mutation_p.E29K|SELPLG_uc010sxe.1_Missense_Mutation_p.E45K	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	29	Extracellular (Potential).			Missing (in Ref. 3; BAC05283).	blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0																		---	---	---	---
UBE3B	89910	broad.mit.edu	37	12	109972426	109972426	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109972426C>T	uc001top.2	+	28	3649	c.3046C>T	c.(3046-3048)CGG>TGG	p.R1016W	UBE3B_uc001toq.2_Missense_Mutation_p.R1016W|UBE3B_uc001tos.2_Missense_Mutation_p.R443W|UBE3B_uc001tot.2_Missense_Mutation_p.R134W|UBE3B_uc010sxp.1_3'UTR	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	1016	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4																		---	---	---	---
ANKRD13A	88455	broad.mit.edu	37	12	110457005	110457005	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110457005C>T	uc001tpx.2	+	6	865	c.606C>T	c.(604-606)TTC>TTT	p.F202F	ANKRD13A_uc009zvl.1_RNA|ANKRD13A_uc009zvm.1_Silent_p.F202F|ANKRD13A_uc010sxw.1_Silent_p.F202F	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13	202											0																		---	---	---	---
ATXN2	6311	broad.mit.edu	37	12	111954043	111954043	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111954043C>T	uc001tsj.2	-	10	1932	c.1770G>A	c.(1768-1770)TCG>TCA	p.S590S	ATXN2_uc001tsh.2_Silent_p.S325S|ATXN2_uc001tsi.2_Silent_p.S301S|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_Silent_p.S325S	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	590	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2																		---	---	---	---
ANAPC5	51433	broad.mit.edu	37	12	121775094	121775094	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121775094C>T	uc001uag.2	-	6	881	c.759G>A	c.(757-759)GCG>GCA	p.A253A	ANAPC5_uc001uae.2_5'Flank|ANAPC5_uc010szv.1_5'Flank|ANAPC5_uc001uaf.2_RNA|ANAPC5_uc001uah.2_Silent_p.A154A|ANAPC5_uc001uai.1_5'UTR	NM_016237	NP_057321	Q9UJX4	APC5_HUMAN	anaphase-promoting complex subunit 5 isoform a	253					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			skin(3)|breast(2)|kidney(1)	6	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)																	---	---	---	---
KDM2B	84678	broad.mit.edu	37	12	122016853	122016853	+	Splice_Site	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122016853T>C	uc001uat.2	-	2	231	c.127_splice	c.e2-1	p.R43_splice	KDM2B_uc001uas.2_Splice_Site_p.R12_splice|KDM2B_uc001uau.2_Splice_Site|KDM2B_uc001uav.3_Splice_Site_p.R43_splice	NM_032590	NP_115979			F-box and leucine-rich repeat protein 10 isoform						embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
RSRC2	65117	broad.mit.edu	37	12	122992836	122992836	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122992836C>T	uc001ucr.2	-	8	1110	c.964G>A	c.(964-966)GCT>ACT	p.A322T	RSRC2_uc001uco.2_Missense_Mutation_p.A91T|RSRC2_uc001ucp.2_Missense_Mutation_p.A263T|RSRC2_uc001ucq.2_Missense_Mutation_p.A90T|RSRC2_uc001ucs.2_Missense_Mutation_p.A91T|RSRC2_uc001uct.2_Missense_Mutation_p.A274T|RSRC2_uc001ucu.2_Missense_Mutation_p.A323T	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	322										ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)														---	---	---	---
P2RX2	22953	broad.mit.edu	37	12	133197083	133197083	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133197083G>A	uc001ukj.1	+	7	688	c.688G>A	c.(688-690)GAG>AAG	p.E230K	P2RX2_uc001uki.1_Missense_Mutation_p.E230K|P2RX2_uc001ukk.1_Missense_Mutation_p.E230K|P2RX2_uc001ukl.1_Missense_Mutation_p.E206K|P2RX2_uc001ukm.1_Missense_Mutation_p.E158K|P2RX2_uc001ukn.1_Missense_Mutation_p.E138K|P2RX2_uc009zyt.1_Missense_Mutation_p.E230K|P2RX2_uc001uko.1_Missense_Mutation_p.R194Q	NM_170682	NP_733782	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X2 isoform A	230	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)														---	---	---	---
POLE	5426	broad.mit.edu	37	12	133256104	133256104	+	Missense_Mutation	SNP	G	A	A	rs151325267	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133256104G>A	uc001uks.1	-	6	601	c.557C>T	c.(556-558)GCG>GTG	p.A186V	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.A159V	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	186					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
ANKLE2	23141	broad.mit.edu	37	12	133319798	133319798	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133319798G>A	uc001ukx.2	-	6	1362	c.1295C>T	c.(1294-1296)TCG>TTG	p.S432L	ANKLE2_uc001uky.3_Missense_Mutation_p.S370L	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	432	ANK.					cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)														---	---	---	---
GOLGA3	2802	broad.mit.edu	37	12	133374948	133374948	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133374948G>A	uc001ukz.1	-	9	2475	c.1916C>T	c.(1915-1917)GCG>GTG	p.A639V	GOLGA3_uc001ula.1_Missense_Mutation_p.A639V|GOLGA3_uc001ulb.2_Missense_Mutation_p.A639V	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	639	Gln-rich.|Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)														---	---	---	---
IFT88	8100	broad.mit.edu	37	13	21264849	21264849	+	Missense_Mutation	SNP	G	A	A	rs138716049		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21264849G>A	uc001unh.2	+	27	2671	c.2275G>A	c.(2275-2277)GGC>AGC	p.G759S	IFT88_uc001uni.2_Missense_Mutation_p.G750S|IFT88_uc001unj.2_Missense_Mutation_p.G749S|IFT88_uc010tcq.1_Missense_Mutation_p.G730S	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	759					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)														---	---	---	---
PARP4	143	broad.mit.edu	37	13	25009229	25009229	+	Silent	SNP	G	A	A	rs145651021	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25009229G>A	uc001upl.2	-	31	4156	c.4050C>T	c.(4048-4050)TTC>TTT	p.F1350F		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1350					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)														---	---	---	---
ATP8A2	51761	broad.mit.edu	37	13	26273359	26273359	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:26273359C>T	uc001uqk.2	+	25	2402	c.2260C>T	c.(2260-2262)CTG>TTG	p.L754L	ATP8A2_uc010tdi.1_Silent_p.L714L|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Silent_p.L304L	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	714	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)														---	---	---	---
WASF3	10810	broad.mit.edu	37	13	27255288	27255288	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:27255288G>A	uc001uqv.2	+	8	1039	c.814G>A	c.(814-816)GTG>ATG	p.V272M	WASF3_uc001uqw.2_Missense_Mutation_p.V269M	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	272					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)														---	---	---	---
FRY	10129	broad.mit.edu	37	13	32705925	32705925	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32705925G>A	uc001utx.2	+	8	1329	c.833G>A	c.(832-834)CGA>CAA	p.R278Q	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)														---	---	---	---
BRCA2	675	broad.mit.edu	37	13	32914985	32914985	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32914985T>C	uc001uub.1	+	11	6720	c.6493T>C	c.(6493-6495)TTG>CTG	p.L2165L		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2165					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)				D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			---	---	---	---
N4BP2L2	10443	broad.mit.edu	37	13	33012780	33012780	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33012780C>T	uc010abe.1	-						N4BP2L2_uc001uug.2_Intron|N4BP2L2_uc010abd.1_Intron|N4BP2L2_uc001uuh.2_Intron|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Intron	NM_033111	NP_149102			phosphonoformate immuno-associated protein 5												0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)														---	---	---	---
STARD13	90627	broad.mit.edu	37	13	33700225	33700225	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33700225A>G	uc001uuw.2	-	7	2201	c.2075T>C	c.(2074-2076)CTC>CCC	p.L692P	STARD13_uc001uuu.2_Missense_Mutation_p.L684P|STARD13_uc001uuv.2_Missense_Mutation_p.L574P|STARD13_uc001uux.2_Missense_Mutation_p.L657P|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	692	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)														---	---	---	---
DCLK1	9201	broad.mit.edu	37	13	36396959	36396959	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:36396959G>A	uc001uvf.2	-	11	1694	c.1461C>T	c.(1459-1461)GAC>GAT	p.D487D	DCLK1_uc001uve.3_Silent_p.D180D|DCLK1_uc010teh.1_Silent_p.D180D|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	487	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)														---	---	---	---
EXOSC8	11340	broad.mit.edu	37	13	37582318	37582318	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37582318A>G	uc001uwa.2	+						EXOSC8_uc001uvz.2_Intron|EXOSC8_uc001uwb.2_Intron|EXOSC8_uc001uwc.2_Intron	NM_181503	NP_852480			exosome component 8						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	AU-rich element binding|identical protein binding			pancreas(1)	1		Lung NSC(96;6.57e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.67e-07)|Epithelial(112;1.31e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00699)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0411)														---	---	---	---
FAM48A	55578	broad.mit.edu	37	13	37599472	37599472	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37599472T>C	uc001uwg.2	-	17	1562	c.1314A>G	c.(1312-1314)CCA>CCG	p.P438P	FAM48A_uc010abt.2_Silent_p.P439P|FAM48A_uc001uwh.2_Silent_p.P439P|FAM48A_uc001uwi.2_Silent_p.P438P|FAM48A_uc001uwj.2_Silent_p.P439P|FAM48A_uc001uwk.2_Silent_p.P438P|FAM48A_uc010tes.1_Silent_p.P402P|FAM48A_uc001uwl.1_Silent_p.P438P|FAM48A_uc001uwd.2_5'Flank|FAM48A_uc001uwe.2_5'Flank|FAM48A_uc001uwf.2_Silent_p.P16P	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	438					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)														---	---	---	---
NAA16	79612	broad.mit.edu	37	13	41894849	41894849	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41894849T>C	uc001uyf.2	+	4	615	c.291T>C	c.(289-291)GAT>GAC	p.D97D	NAA16_uc010tfg.1_RNA|NAA16_uc001uye.3_Silent_p.D97D|NAA16_uc001uyd.3_Silent_p.D97D	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	97	TPR 2.				N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1																		---	---	---	---
AKAP11	11215	broad.mit.edu	37	13	42873557	42873557	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42873557T>C	uc001uys.1	+	8	850	c.675T>C	c.(673-675)GGT>GGC	p.G225G		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	225					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)														---	---	---	---
ENOX1	55068	broad.mit.edu	37	13	43930086	43930086	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:43930086G>A	uc001uza.3	-	8	1092	c.792C>T	c.(790-792)CAC>CAT	p.H264H	ENOX1_uc001uzb.3_Silent_p.H264H|ENOX1_uc001uzc.3_Silent_p.H264H|ENOX1_uc001uyz.3_Translation_Start_Site|ENOX1_uc010tfm.1_Silent_p.H77H	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	264					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)														---	---	---	---
CPB2	1361	broad.mit.edu	37	13	46661878	46661878	+	Splice_Site	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46661878A>G	uc001vaw.2	-	2	217	c.150_splice	c.e2+1	p.E50_splice	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Splice_Site_p.E50_splice	NM_001872	NP_001863			plasma carboxypeptidase B2 isoform a						blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)														---	---	---	---
FAM124A	220108	broad.mit.edu	37	13	51854975	51854975	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:51854975G>T	uc001vfg.1	+	4	1355	c.1224G>T	c.(1222-1224)GGG>GGT	p.G408G	FAM124A_uc001vff.1_Silent_p.G444G	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	408										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)														---	---	---	---
THSD1	55901	broad.mit.edu	37	13	52960165	52960165	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52960165G>A	uc001vgo.2	-	4	1723	c.1178C>T	c.(1177-1179)GCT>GTT	p.A393V	THSD1_uc001vgp.2_Intron|THSD1_uc010tgz.1_Missense_Mutation_p.A14V|THSD1_uc010aea.2_Intron	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	393	Extracellular (Potential).|TSP type-1.					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)														---	---	---	---
PCDH9	5101	broad.mit.edu	37	13	67801400	67801400	+	Missense_Mutation	SNP	C	A	A	rs139934102	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:67801400C>A	uc001vik.2	-	2	1865	c.1173G>T	c.(1171-1173)AAG>AAT	p.K391N	PCDH9_uc001vil.2_Missense_Mutation_p.K391N|PCDH9_uc010thl.1_Missense_Mutation_p.K391N|PCDH9_uc001vin.3_Missense_Mutation_p.K391N	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	391	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)														---	---	---	---
KLHL1	57626	broad.mit.edu	37	13	70371098	70371098	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:70371098A>G	uc001vip.2	-						KLHL1_uc010thm.1_Intron	NM_020866	NP_065917			kelch-like 1 protein						actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)														---	---	---	---
SCEL	8796	broad.mit.edu	37	13	78176201	78176201	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:78176201A>G	uc001vki.2	+	16	1089	c.919A>G	c.(919-921)ATC>GTC	p.I307V	SCEL_uc001vkj.2_Missense_Mutation_p.I287V|SCEL_uc010thx.1_Missense_Mutation_p.I285V	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	307	16 X approximate tandem repeats.|4.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)														---	---	---	---
SLAIN1	122060	broad.mit.edu	37	13	78318470	78318470	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:78318470G>A	uc010thy.1	+	3	370	c.327G>A	c.(325-327)GAG>GAA	p.E109E	SLAIN1_uc001vkk.1_Silent_p.E32E|SLAIN1_uc001vkl.1_5'UTR|SLAIN1_uc010thz.1_5'UTR|SLAIN1_uc010aex.1_5'UTR|SLAIN1_uc010aey.1_5'UTR|SLAIN1_uc001vkm.2_5'UTR	NM_144595	NP_653196	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1 B	251										ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)														---	---	---	---
SLITRK5	26050	broad.mit.edu	37	13	88329581	88329581	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:88329581C>T	uc001vln.2	+	2	2157	c.1938C>T	c.(1936-1938)ACC>ACT	p.T646T	SLITRK5_uc010tic.1_Silent_p.T405T	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	646	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)																	---	---	---	---
GPC5	2262	broad.mit.edu	37	13	92345891	92345891	+	Missense_Mutation	SNP	C	A	A	rs141328977		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:92345891C>A	uc010tif.1	+	3	1142	c.776C>A	c.(775-777)CCG>CAG	p.P259Q		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	259						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)																---	---	---	---
ABCC4	10257	broad.mit.edu	37	13	95714990	95714990	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95714990C>T	uc001vmd.3	-	26	3453	c.3334G>A	c.(3334-3336)GAT>AAT	p.D1112N	ABCC4_uc010afj.2_5'UTR|ABCC4_uc010afk.2_Missense_Mutation_p.D1065N	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	1112	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)													---	---	---	---
UGGT2	55757	broad.mit.edu	37	13	96529620	96529620	+	Splice_Site	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:96529620T>C	uc001vmt.2	-	29	3558	c.3388_splice	c.e29-1	p.G1130_splice	UGGT2_uc001vmu.1_3'UTR	NM_020121	NP_064506			UDP-glucose ceramide glucosyltransferase-like 2						post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
FARP1	10160	broad.mit.edu	37	13	99087849	99087849	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99087849G>T	uc001vnj.2	+	19	2499	c.2163G>T	c.(2161-2163)ACG>ACT	p.T721T	FARP1_uc001vnh.2_Silent_p.T721T	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	721	DH.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)															---	---	---	---
DOCK9	23348	broad.mit.edu	37	13	99515326	99515326	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99515326C>T	uc001vnt.2	-	32	3584	c.3529G>A	c.(3529-3531)GTC>ATC	p.V1177I	DOCK9_uc001vnw.2_Missense_Mutation_p.V1176I|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.V1177I|DOCK9_uc010tis.1_Missense_Mutation_p.V1176I|DOCK9_uc010tit.1_Missense_Mutation_p.V1177I|DOCK9_uc010tiq.1_Missense_Mutation_p.V155I|DOCK9_uc010afu.1_Missense_Mutation_p.V1023I	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1177					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
TMTC4	84899	broad.mit.edu	37	13	101277913	101277913	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101277913G>A	uc001vou.2	-	14	1815	c.1655C>T	c.(1654-1656)GCG>GTG	p.A552V	TMTC4_uc001vot.2_Missense_Mutation_p.A571V|TMTC4_uc010tja.1_Missense_Mutation_p.A441V|TMTC4_uc001vov.1_Missense_Mutation_p.A297V|TMTC4_uc001vow.1_Missense_Mutation_p.A335V	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	552	TPR 4.					integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
COL4A2	1284	broad.mit.edu	37	13	111109772	111109772	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:111109772G>T	uc001vqx.2	+	21	1711	c.1422G>T	c.(1420-1422)AAG>AAT	p.K474N		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	474	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)															---	---	---	---
MCF2L	23263	broad.mit.edu	37	13	113740563	113740563	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113740563C>T	uc001vsu.2	+	21	2566	c.2544C>T	c.(2542-2544)GAC>GAT	p.D848D	MCF2L_uc001vsq.2_Silent_p.D848D|MCF2L_uc010tjr.1_Silent_p.D791D|MCF2L_uc001vsr.2_Silent_p.D795D|MCF2L_uc001vss.3_Silent_p.D789D|MCF2L_uc010tjs.1_Silent_p.D789D|MCF2L_uc001vst.1_Silent_p.D753D	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	821					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)																---	---	---	---
F10	2159	broad.mit.edu	37	13	113803259	113803259	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113803259G>A	uc001vsx.2	+	8	952	c.895G>A	c.(895-897)GGT>AGT	p.G299S	F10_uc001vsy.2_Silent_p.A295A|F10_uc001vsz.2_Silent_p.A297A	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	299	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
PCID2	55795	broad.mit.edu	37	13	113833353	113833353	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113833353G>A	uc010tju.1	-	13	1118	c.1037C>T	c.(1036-1038)GCC>GTC	p.A346V	PCID2_uc001vtb.2_Missense_Mutation_p.A179V|PCID2_uc010tjv.1_Missense_Mutation_p.A346V|PCID2_uc010tjw.1_Missense_Mutation_p.A346V|PCID2_uc001vte.2_Missense_Mutation_p.A239V|PCID2_uc001vtd.2_Missense_Mutation_p.A239V|PCID2_uc001vtf.2_Missense_Mutation_p.A239V	NM_001127203	NP_001120675	Q5JVF3	PCID2_HUMAN	PCI domain containing 2	346	PCI.				negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)															---	---	---	---
PCID2	55795	broad.mit.edu	37	13	113851338	113851338	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113851338T>C	uc010tju.1	-						PCID2_uc010tjv.1_Intron|PCID2_uc010tjw.1_Intron|PCID2_uc001vte.2_Intron|PCID2_uc001vtd.2_Intron|PCID2_uc001vtf.2_Intron|PCID2_uc001vtg.1_RNA	NM_001127203	NP_001120675			PCI domain containing 2						negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)															---	---	---	---
POTEG	404785	broad.mit.edu	37	14	19553784	19553784	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:19553784A>G	uc001vuz.1	+	1	420	c.368A>G	c.(367-369)TAC>TGC	p.Y123C	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	123										ovary(1)	1																		---	---	---	---
PARP2	10038	broad.mit.edu	37	14	20813247	20813247	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20813247G>A	uc001vxc.2	+	2	231	c.203G>A	c.(202-204)GGT>GAT	p.G68D	RPPH1_uc001vxa.1_5'Flank|PARP2_uc001vxd.2_Splice_Site_p.E68_splice|PARP2_uc001vxb.1_Missense_Mutation_p.G68D	NM_005484	NP_005475	Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase family, member 2	68	Potential.				protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			ovary(1)|pancreas(1)	2	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)									Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					---	---	---	---
TMEM55B	90809	broad.mit.edu	37	14	20928395	20928395	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20928395G>T	uc001vxl.2	-	3	549	c.396C>A	c.(394-396)ATC>ATA	p.I132I	TMEM55B_uc001vxk.2_Silent_p.I139I	NM_144568	NP_653169	Q86T03	TM55B_HUMAN	transmembrane protein 55B isoform 2	132						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)														---	---	---	---
CHD8	57680	broad.mit.edu	37	14	21871355	21871355	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21871355T>C	uc001was.1	-	18	2792	c.2698A>G	c.(2698-2700)ATT>GTT	p.I900V	CHD8_uc001war.1_Missense_Mutation_p.I796V|CHD8_uc001wav.1_Missense_Mutation_p.I342V	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1179	Helicase C-terminal.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)														---	---	---	---
CDH24	64403	broad.mit.edu	37	14	23517694	23517694	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23517694C>T	uc001wil.2	-						CDH24_uc001wik.3_Intron|CDH24_uc010akf.2_Intron	NM_022478	NP_071923			cadherin-like 24 isoform 1						adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)														---	---	---	---
ACIN1	22985	broad.mit.edu	37	14	23549510	23549510	+	Missense_Mutation	SNP	G	A	A	rs12589748	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23549510G>A	uc001wit.3	-	6	1536	c.1208C>T	c.(1207-1209)GCG>GTG	p.A403V	ACIN1_uc001wis.3_Missense_Mutation_p.A85V|ACIN1_uc010akg.2_Missense_Mutation_p.A403V|ACIN1_uc010tnj.1_Missense_Mutation_p.A363V	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	403	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)														---	---	---	---
CPNE6	9362	broad.mit.edu	37	14	24546935	24546935	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24546935C>T	uc001wll.2	+	16	1769	c.1670C>T	c.(1669-1671)CCG>CTG	p.P557L	CPNE6_uc010tnv.1_Missense_Mutation_p.P612L|CPNE6_uc001wlm.2_Missense_Mutation_p.P382L|CPNE6_uc001wln.2_3'UTR	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	557					lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)														---	---	---	---
PSME2	5721	broad.mit.edu	37	14	24613431	24613431	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24613431T>C	uc001wmj.2	-	8	532	c.467A>G	c.(466-468)AAA>AGA	p.K156R	FAM158A_uc001wmi.2_5'Flank|PSME2_uc001wmk.2_Missense_Mutation_p.K79R|RNF31_uc001wml.1_5'Flank	NM_002818	NP_002809	Q9UL46	PSME2_HUMAN	proteasome activator subunit 2	156					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome activator complex					0				GBM - Glioblastoma multiforme(265;0.00839)														---	---	---	---
IPO4	79711	broad.mit.edu	37	14	24649726	24649726	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24649726G>A	uc001wmv.1	-	30	3299	c.3168C>T	c.(3166-3168)ACC>ACT	p.T1056T	IPO4_uc001wmt.1_Silent_p.T536T|IPO4_uc001wmu.2_Silent_p.T718T|IPO4_uc001wmx.1_Silent_p.T920T|IPO4_uc001wmy.1_Silent_p.T920T|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Silent_p.T1056T	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	1056					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)														---	---	---	---
FOXG1	2290	broad.mit.edu	37	14	29237480	29237480	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:29237480C>T	uc001wqe.2	+	1	1194	c.995C>T	c.(994-996)TCG>TTG	p.S332L		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	332					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)														---	---	---	---
SCFD1	23256	broad.mit.edu	37	14	31169382	31169382	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31169382T>C	uc001wqm.1	+						SCFD1_uc001wqn.1_Intron|SCFD1_uc010tpg.1_Intron|SCFD1_uc010tph.1_Intron|SCFD1_uc010amf.1_Intron|SCFD1_uc010tpi.1_Intron|SCFD1_uc010amd.1_Intron|SCFD1_uc010ame.1_Intron	NM_016106	NP_057190			vesicle transport-related protein isoform a						post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)														---	---	---	---
INSM2	84684	broad.mit.edu	37	14	36003451	36003451	+	5'UTR	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36003451A>G	uc001wth.1	+	1						NM_032594	NP_115983			insulinoma-associated protein IA-6						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)														---	---	---	---
BRMS1L	84312	broad.mit.edu	37	14	36300660	36300660	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36300660G>A	uc001wtl.2	+	2	313	c.187G>A	c.(187-189)GAT>AAT	p.D63N	BRMS1L_uc010tpx.1_Missense_Mutation_p.D15N	NM_032352	NP_115728	Q5PSV4	BRM1L_HUMAN	breast cancer metastasis-suppressor 1-like	63	Potential.				regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				skin(1)	1	Breast(36;0.137)|Hepatocellular(127;0.158)		Lung(8;1.7e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.00467)|all cancers(34;0.0157)|BRCA - Breast invasive adenocarcinoma(188;0.158)	GBM - Glioblastoma multiforme(112;0.0333)														---	---	---	---
MBIP	51562	broad.mit.edu	37	14	36780790	36780790	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36780790C>T	uc001wtm.2	-	6	867	c.779G>A	c.(778-780)CGG>CAG	p.R260Q	MBIP_uc001wto.2_Missense_Mutation_p.R260Q|MBIP_uc010tpy.1_Missense_Mutation_p.R119Q|MBIP_uc001wtn.2_Missense_Mutation_p.R260Q	NM_016586	NP_057670	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1 isoform 1	260	Interaction with MAP3K12.				histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)														---	---	---	---
PAX9	5083	broad.mit.edu	37	14	37132270	37132270	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:37132270C>T	uc001wty.3	+	3	890	c.173C>T	c.(172-174)GCG>GTG	p.A58V	PAX9_uc010amq.2_5'Flank	NM_006194	NP_006185	P55771	PAX9_HUMAN	paired box 9	58	Paired.				multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)														---	---	---	---
SEC23A	10484	broad.mit.edu	37	14	39532546	39532546	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39532546A>G	uc001wup.1	-	12	1603	c.1380T>C	c.(1378-1380)TAT>TAC	p.Y460Y	SEC23A_uc010tqa.1_Silent_p.Y322Y|SEC23A_uc010tqb.1_Silent_p.Y431Y|SEC23A_uc010tqc.1_Silent_p.Y322Y	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	460					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)														---	---	---	---
SEC23A	10484	broad.mit.edu	37	14	39565194	39565194	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39565194T>C	uc001wup.1	-	2	352	c.129A>G	c.(127-129)ACA>ACG	p.T43T	SEC23A_uc010tqa.1_Intron|SEC23A_uc010tqb.1_Silent_p.T43T	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	43					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)														---	---	---	---
FAM179B	23116	broad.mit.edu	37	14	45475281	45475281	+	Silent	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45475281A>C	uc001wvv.2	+	5	2924	c.2715A>C	c.(2713-2715)CGA>CGC	p.R905R	FAM179B_uc001wvw.2_Silent_p.R905R|FAM179B_uc010anc.2_RNA|FAM179B_uc001wvu.2_Silent_p.R905R	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	905							binding			skin(2)|upper_aerodigestive_tract(1)	3																		---	---	---	---
CDKL1	8814	broad.mit.edu	37	14	50863894	50863894	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50863894T>C	uc010anu.1	-	4	396	c.396A>G	c.(394-396)GGA>GGG	p.G132G	CDKL1_uc001wxz.2_5'Flank	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	Error:Variant_position_missing_in_Q00532_after_alignment						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)																	---	---	---	---
FRMD6	122786	broad.mit.edu	37	14	52186842	52186842	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:52186842G>T	uc001wzd.2	+	11	1379	c.1094G>T	c.(1093-1095)CGG>CTG	p.R365L	FRMD6_uc001wzb.2_Missense_Mutation_p.R357L|FRMD6_uc001wzc.2_Missense_Mutation_p.R357L|FRMD6_uc001wze.2_Missense_Mutation_p.R288L|FRMD6_uc001wzf.2_Missense_Mutation_p.R58L|FRMD6_uc001wzg.2_Missense_Mutation_p.R7L	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	365						cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)																	---	---	---	---
BMP4	652	broad.mit.edu	37	14	54418806	54418806	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:54418806G>T	uc001xal.3	-	2	322	c.135C>A	c.(133-135)CGC>CGA	p.R45R	BMP4_uc010aoh.2_Silent_p.R45R|BMP4_uc001xao.3_Silent_p.R45R|BMP4_uc001xan.3_Silent_p.R45R	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	45					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0																		---	---	---	---
EXOC5	10640	broad.mit.edu	37	14	57698340	57698340	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:57698340G>T	uc001xct.2	-	11	1283	c.1032C>A	c.(1030-1032)TCC>TCA	p.S344S	EXOC5_uc001xcs.2_Silent_p.S23S|EXOC5_uc010trg.1_Silent_p.S289S|EXOC5_uc010trh.1_Silent_p.S279S	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein	344					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3																		---	---	---	---
SFRS5	6430	broad.mit.edu	37	14	70235592	70235592	+	Missense_Mutation	SNP	G	A	A	rs149440957	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:70235592G>A	uc001xll.2	+	5	1726	c.275G>A	c.(274-276)CGC>CAC	p.R92H	SFRS5_uc001xlm.2_RNA|SFRS5_uc001xln.1_Missense_Mutation_p.R92H|SFRS5_uc001xlo.2_Missense_Mutation_p.R92H|SFRS5_uc001xlp.2_Missense_Mutation_p.R92H|SFRS5_uc001xlq.2_Missense_Mutation_p.R89H	NM_006925	NP_008856	Q13243	SRSF5_HUMAN	splicing factor, arginine/serine-rich 5	92					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding				0				all cancers(60;0.00144)|BRCA - Breast invasive adenocarcinoma(234;0.0132)|OV - Ovarian serous cystadenocarcinoma(108;0.0154)														---	---	---	---
ADAM21	8747	broad.mit.edu	37	14	70925078	70925078	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:70925078T>C	uc001xmd.2	+	1	862	c.862T>C	c.(862-864)TCC>CCC	p.S288P		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	288	Peptidase M12B.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)														---	---	---	---
RGS6	9628	broad.mit.edu	37	14	73029147	73029147	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73029147G>A	uc001xna.3	+	17	1914	c.1391G>A	c.(1390-1392)CGC>CAC	p.R464H	RGS6_uc010ttn.1_Missense_Mutation_p.R482H|RGS6_uc001xmx.3_Missense_Mutation_p.R464H|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.R482H|RGS6_uc001xmz.1_Intron	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	464					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)														---	---	---	---
C14orf169	79697	broad.mit.edu	37	14	73959137	73959137	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73959137G>A	uc001xok.1	+	3	1495	c.1416G>A	c.(1414-1416)CCG>CCA	p.P472P	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	472					negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)														---	---	---	---
COQ6	51004	broad.mit.edu	37	14	74424920	74424920	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74424920C>A	uc001xph.2	+	5	632	c.552C>A	c.(550-552)GAC>GAA	p.D184E	ENTPD5_uc001xpi.2_3'UTR|COQ6_uc001xpe.2_Missense_Mutation_p.D109E|COQ6_uc001xpf.2_Missense_Mutation_p.D109E|COQ6_uc010tuk.1_Missense_Mutation_p.D159E|COQ6_uc010tul.1_Missense_Mutation_p.D129E|COQ6_uc010tum.1_Missense_Mutation_p.D184E|COQ6_uc010tun.1_Missense_Mutation_p.D129E|COQ6_uc001xpg.2_Missense_Mutation_p.D184E	NM_182476	NP_872282	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 homolog isoform a	184					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.00337)														---	---	---	---
LTBP2	4053	broad.mit.edu	37	14	74969608	74969608	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74969608G>A	uc001xqa.2	-	34	5305	c.4918C>T	c.(4918-4920)CGC>TGC	p.R1640C		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1640					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)														---	---	---	---
ANGEL1	23357	broad.mit.edu	37	14	77257053	77257053	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77257053G>A	uc001xsv.2	-	9	1866	c.1753C>T	c.(1753-1755)CGT>TGT	p.R585C	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	585										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)														---	---	---	---
ADCK1	57143	broad.mit.edu	37	14	78397874	78397874	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:78397874G>A	uc001xui.2	+	10	1319	c.1220G>A	c.(1219-1221)CGC>CAC	p.R407H	ADCK1_uc001xuj.2_Missense_Mutation_p.R339H|ADCK1_uc001xul.2_Missense_Mutation_p.R114H	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	414	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)														---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	78710088	78710088	+	RNA	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:78710088G>A	uc001xum.1	+	2		c.1445G>A								Homo sapiens mRNA for KIAA0743 protein, partial cds.						axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
C14orf145	145508	broad.mit.edu	37	14	81366324	81366324	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81366324C>T	uc001xux.2	-	6	701	c.530G>A	c.(529-531)CGC>CAC	p.R177H	C14orf145_uc001xuz.2_Missense_Mutation_p.R177H|C14orf145_uc001xva.1_Missense_Mutation_p.R177H|C14orf145_uc001xuy.1_Missense_Mutation_p.R35H	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	177						centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)														---	---	---	---
SEL1L	6400	broad.mit.edu	37	14	81952096	81952096	+	Intron	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81952096G>T	uc010tvv.1	-							NM_005065	NP_005056			sel-1 suppressor of lin-12-like precursor						Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)														---	---	---	---
SLC24A4	123041	broad.mit.edu	37	14	92905714	92905714	+	Silent	SNP	C	T	T	rs146323738	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92905714C>T	uc001yak.2	+	4	327	c.303C>T	c.(301-303)TGC>TGT	p.C101C	SLC24A4_uc001yai.2_Silent_p.C54C|SLC24A4_uc010twm.1_Silent_p.C118C|SLC24A4_uc001yaj.2_Silent_p.C101C|SLC24A4_uc010auj.2_Silent_p.C9C	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	118	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)														---	---	---	---
RIN3	79890	broad.mit.edu	37	14	93125676	93125676	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93125676G>A	uc001yap.2	+	7	2349	c.2197G>A	c.(2197-2199)GTG>ATG	p.V733M	RIN3_uc010auk.2_Missense_Mutation_p.V395M|RIN3_uc001yaq.2_Missense_Mutation_p.V658M|RIN3_uc001yar.1_Missense_Mutation_p.V395M|RIN3_uc001yas.1_Missense_Mutation_p.V395M	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	733	VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)																---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	94158100	94158100	+	Silent	SNP	C	T	T	rs151304420		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94158100C>T	uc001ybv.1	+	45	7013	c.6930C>T	c.(6928-6930)TCC>TCT	p.S2310S	KIAA1409_uc001ybs.1_Silent_p.S2288S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2465						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
SERPINA6	866	broad.mit.edu	37	14	94776106	94776106	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94776106G>A	uc001ycv.2	-	3	955	c.851C>T	c.(850-852)ACG>ATG	p.T284M	SERPINA6_uc010auv.2_RNA	NM_001756	NP_001747	P08185	CBG_HUMAN	corticosteroid binding globulin precursor	284					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			skin(3)|ovary(1)|central_nervous_system(1)	5		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)													---	---	---	---
DICER1	23405	broad.mit.edu	37	14	95596387	95596387	+	Intron	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95596387A>T	uc001ydw.2	-						DICER1_uc001ydv.2_Intron|DICER1_uc001ydx.2_Intron	NM_030621	NP_085124			dicer1						negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)				Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				---	---	---	---
C14orf49	161176	broad.mit.edu	37	14	95921913	95921913	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95921913C>T	uc001yei.3	-	5	953	c.938G>A	c.(937-939)CGC>CAC	p.R313H	C14orf49_uc010avi.2_Missense_Mutation_p.R313H|C14orf49_uc001yej.1_Missense_Mutation_p.R313H	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	313	Spectrin 1.|Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)														---	---	---	---
C14orf49	161176	broad.mit.edu	37	14	95923557	95923557	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95923557C>T	uc001yei.3	-	4	761	c.746G>A	c.(745-747)CGG>CAG	p.R249Q	C14orf49_uc010avi.2_Missense_Mutation_p.R249Q|C14orf49_uc001yej.1_Missense_Mutation_p.R249Q	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	249	Spectrin 1.|Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)														---	---	---	---
C14orf129	51527	broad.mit.edu	37	14	96851949	96851949	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96851949C>T	uc001yfj.3	+	4	493	c.348C>T	c.(346-348)CCC>CCT	p.P116P	C14orf129_uc001yfl.2_Silent_p.P116P	NM_016472	NP_057556	Q9P0R6	GSKIP_HUMAN	chromosome 14 open reading frame 129	116	Interaction with GSK3B.					cytoplasm	protein binding				0		Melanoma(154;0.226)		Epithelial(152;0.109)|COAD - Colon adenocarcinoma(157;0.205)														---	---	---	---
PAPOLA	10914	broad.mit.edu	37	14	96986463	96986463	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96986463G>A	uc001yfq.2	+	2	290	c.80G>A	c.(79-81)AGC>AAC	p.S27N	PAPOLA_uc001yfo.2_Missense_Mutation_p.S27N|PAPOLA_uc001yfp.2_Missense_Mutation_p.S27N|PAPOLA_uc001yfr.2_Missense_Mutation_p.S27N|PAPOLA_uc010twv.1_Missense_Mutation_p.S27N|PAPOLA_uc010avp.2_5'UTR	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	27					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)														---	---	---	---
CCNK	8812	broad.mit.edu	37	14	99969288	99969288	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:99969288G>T	uc001ygi.3	+	8	1108	c.978G>T	c.(976-978)CAG>CAT	p.Q326H	CCNK_uc001ygg.3_Intron	NM_001099402	NP_001092872	O75909	CCNK_HUMAN	cyclin K isoform 1	326					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding				0		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)																---	---	---	---
WARS	7453	broad.mit.edu	37	14	100808882	100808882	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:100808882G>A	uc001yhf.1	-	8	1050	c.966C>T	c.(964-966)GAC>GAT	p.D322D	WARS_uc001yhe.1_Silent_p.D128D|WARS_uc001yhg.1_Silent_p.D322D|WARS_uc001yhh.1_Silent_p.D322D|WARS_uc001yhi.1_Silent_p.D281D|WARS_uc001yhj.1_Silent_p.D281D|WARS_uc001yhk.1_Silent_p.D281D|WARS_uc001yhl.1_Silent_p.D322D	NM_173701	NP_776049	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase isoform a	322					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(1)	1		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)													---	---	---	---
XRCC3	7517	broad.mit.edu	37	14	104165790	104165790	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:104165790C>T	uc001yny.3	-	8	1065	c.685G>A	c.(685-687)GCC>ACC	p.A229T	KLC1_uc010tyf.1_Intron|KLC1_uc001yno.2_Intron|KLC1_uc001yns.2_Intron|XRCC3_uc001ynx.3_Missense_Mutation_p.A229T|XRCC3_uc001ynz.3_Missense_Mutation_p.A229T|XRCC3_uc001yoa.3_Missense_Mutation_p.A229T	NM_005432	NP_005423	O43542	XRCC3_HUMAN	X-ray repair cross complementing protein 3	229					DNA recombination|DNA repair	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0		Melanoma(154;0.155)|all_epithelial(191;0.19)		Epithelial(152;0.239)									Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105414613	105414613	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105414613G>A	uc010axc.1	-	7	7295	c.7175C>T	c.(7174-7176)CCG>CTG	p.P2392L	AHNAK2_uc001ypx.2_Missense_Mutation_p.P2292L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2392						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
GPR132	29933	broad.mit.edu	37	14	105517868	105517868	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105517868G>T	uc001yqd.2	-	4	1505	c.606C>A	c.(604-606)GCC>GCA	p.A202A	GPR132_uc001yqc.2_Silent_p.A14A|GPR132_uc001yqe.2_Silent_p.A193A	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	202	Helical; Name=5; (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)														---	---	---	---
BTBD6	90135	broad.mit.edu	37	14	105716569	105716569	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105716569C>T	uc010tyq.1	+	5	1126	c.1018C>T	c.(1018-1020)CGA>TGA	p.R340*	BRF1_uc010tyo.1_Intron|BRF1_uc010typ.1_Intron|BRF1_uc001yql.2_5'Flank|BRF1_uc001yqo.2_5'Flank|BRF1_uc010axg.1_Intron|BRF1_uc001yqp.2_Intron|BRF1_uc001yqn.2_5'Flank|BRF1_uc010axh.1_5'Flank|BRF1_uc010axj.1_5'Flank	NM_033271	NP_150374	Q96KE9	BTBD6_HUMAN	BTB domain protein BDPL	340						cytoplasmic mRNA processing body					0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.0163)|Epithelial(46;0.0391)	Epithelial(152;0.18)														---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106110840	106110840	+	RNA	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106110840C>T	uc010tyt.1	-	3640		c.60921G>A			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_RNA					Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106725223	106725223	+	RNA	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106725223G>A	uc010tyt.1	-	588		c.18324C>T								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106829805	106829805	+	RNA	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106829805C>G	uc010tyt.1	-	323		c.12700G>C			uc001ysx.1_RNA					Parts of antibodies, mostly variable regions.												0																		---	---	---	---
NIPA1	123606	broad.mit.edu	37	15	23048857	23048857	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23048857A>G	uc001yvc.2	-	5	987	c.962T>C	c.(961-963)ATG>ACG	p.M321T	NIPA1_uc001yvd.2_Missense_Mutation_p.M151T|NIPA1_uc001yve.2_Missense_Mutation_p.M246T	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	321	Cytoplasmic (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)														---	---	---	---
NIPA1	123606	broad.mit.edu	37	15	23048996	23048996	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23048996C>T	uc001yvc.2	-	5	848	c.823G>A	c.(823-825)GCC>ACC	p.A275T	NIPA1_uc001yvd.2_Missense_Mutation_p.A105T|NIPA1_uc001yve.2_Missense_Mutation_p.A200T	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	275	Helical; (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)														---	---	---	---
NIPA1	123606	broad.mit.edu	37	15	23049218	23049218	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23049218A>C	uc001yvc.2	-	5	626	c.601T>G	c.(601-603)TTC>GTC	p.F201V	NIPA1_uc001yvd.2_Missense_Mutation_p.F31V|NIPA1_uc001yve.2_Missense_Mutation_p.F126V	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	201	Helical; (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)														---	---	---	---
NDN	4692	broad.mit.edu	37	15	23932081	23932081	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23932081G>A	uc001ywk.2	-	1	370	c.284C>T	c.(283-285)CCG>CTG	p.P95L		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	95					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)										Prader-Willi_syndrome				---	---	---	---
ATP10A	57194	broad.mit.edu	37	15	25953381	25953381	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25953381G>A	uc010ayu.2	-	11	2517	c.2411C>T	c.(2410-2412)GCG>GTG	p.A804V		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	804	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)														---	---	---	---
GABRG3	2567	broad.mit.edu	37	15	27777969	27777969	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:27777969T>C	uc001zbg.1	+	10	1512	c.1346T>C	c.(1345-1347)TTC>TCC	p.F449S		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	449	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)														---	---	---	---
OCA2	4948	broad.mit.edu	37	15	28090167	28090167	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28090167G>A	uc001zbh.3	-	23	2480	c.2370C>T	c.(2368-2370)AAC>AAT	p.N790N	OCA2_uc010ayv.2_Silent_p.N766N	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	790	Extracellular (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)										Oculocutaneous_Albinism				---	---	---	---
APBA2	321	broad.mit.edu	37	15	29346438	29346438	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:29346438C>T	uc001zck.2	+	3	558	c.351C>T	c.(349-351)AAC>AAT	p.N117N	APBA2_uc010azj.2_Silent_p.N117N|APBA2_uc010uat.1_Silent_p.N117N|APBA2_uc001zcl.2_Silent_p.N117N|APBA2_uc010uas.1_Silent_p.N117N	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	117					nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	33873743	33873743	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33873743G>A	uc001zhi.2	+	14	1542	c.1472G>A	c.(1471-1473)CGC>CAC	p.R491H	RYR3_uc010bar.2_Missense_Mutation_p.R491H	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	491	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
EIF2AK4	440275	broad.mit.edu	37	15	40308866	40308866	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40308866A>G	uc001zkm.1	+	28	3973	c.3923A>G	c.(3922-3924)AAG>AGG	p.K1308R	EIF2AK4_uc010bbj.1_Missense_Mutation_p.K1009R|EIF2AK4_uc001zkn.1_Missense_Mutation_p.K408R|EIF2AK4_uc001zko.1_Intron|EIF2AK4_uc010bbk.1_RNA	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	1308	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)														---	---	---	---
FAM82A2	55177	broad.mit.edu	37	15	41029864	41029864	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41029864T>C	uc001zmo.1	-	10	1330	c.1186A>G	c.(1186-1188)AGT>GGT	p.S396G	FAM82A2_uc001zmp.1_Missense_Mutation_p.S396G|FAM82A2_uc001zmq.1_Missense_Mutation_p.S396G	NM_018145	NP_060615	Q96TC7	RMD3_HUMAN	family with sequence similarity 82, member A2	396					apoptosis|cell differentiation	integral to membrane|microtubule|mitochondrial membrane|nucleus|spindle pole	protein binding				0																		---	---	---	---
INO80	54617	broad.mit.edu	37	15	41362706	41362706	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41362706T>C	uc001zni.2	-	13	1858	c.1645A>G	c.(1645-1647)AAA>GAA	p.K549E	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	549	ATP (By similarity).|Helicase ATP-binding.|Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
ITPKA	3706	broad.mit.edu	37	15	41794637	41794637	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41794637C>T	uc001znz.2	+	5	1057	c.1046C>T	c.(1045-1047)ACG>ATG	p.T349M		NM_002220	NP_002211	P23677	IP3KA_HUMAN	1D-myo-inositol-trisphosphate 3-kinase A	349					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)														---	---	---	---
VPS39	23339	broad.mit.edu	37	15	42459039	42459039	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42459039C>T	uc001zpd.2	-	15	1634	c.1483G>A	c.(1483-1485)GTG>ATG	p.V495M	VPS39_uc001zpc.2_Missense_Mutation_p.V484M|VPS39_uc001zpb.2_5'Flank	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	495					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)														---	---	---	---
ZFP106	64397	broad.mit.edu	37	15	42743481	42743481	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42743481G>T	uc001zpw.2	-	2	1255	c.920C>A	c.(919-921)CCT>CAT	p.P307H	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Missense_Mutation_p.P90H|ZFP106_uc001zpy.1_Missense_Mutation_p.P330H	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	307						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)														---	---	---	---
DUOX2	50506	broad.mit.edu	37	15	45388103	45388103	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45388103C>T	uc010bea.2	-	30	4206	c.4003G>A	c.(4003-4005)GCA>ACA	p.A1335T	DUOX2_uc001zun.2_Missense_Mutation_p.A1335T	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	1335	Cytoplasmic (Potential).|FAD-binding FR-type.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)														---	---	---	---
MIR147B	100126311	broad.mit.edu	37	15	45725301	45725301	+	RNA	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45725301C>T	hsa-mir-147b|MI0005544	+			c.54C>T			C15orf48_uc001zvg.2_3'UTR|C15orf48_uc001zvh.2_3'UTR																	0																		---	---	---	---
FBN1	2200	broad.mit.edu	37	15	48752456	48752456	+	Silent	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48752456G>C	uc001zwx.1	-	43	5611	c.5283C>G	c.(5281-5283)ACC>ACG	p.T1761T	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1761					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)														---	---	---	---
NEDD4	4734	broad.mit.edu	37	15	56134223	56134223	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:56134223A>T	uc002adj.2	-	15	3304	c.3004T>A	c.(3004-3006)TTG>ATG	p.L1002M	NEDD4_uc002adl.2_Missense_Mutation_p.L583M|NEDD4_uc002adi.2_Missense_Mutation_p.L930M|NEDD4_uc010ugj.1_Missense_Mutation_p.L986M|NEDD4_uc010bfm.2_Missense_Mutation_p.L985M|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1002	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)														---	---	---	---
VPS13C	54832	broad.mit.edu	37	15	62209578	62209578	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:62209578G>T	uc002agz.2	-	60	8091	c.8017C>A	c.(8017-8019)CGG>AGG	p.R2673R	VPS13C_uc002aha.2_Silent_p.R2630R|VPS13C_uc002ahb.1_Silent_p.R2673R|VPS13C_uc002ahc.1_Silent_p.R2630R|VPS13C_uc002ahd.1_Silent_p.R50R	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2673					protein localization					ovary(2)	2																		---	---	---	---
TLN2	83660	broad.mit.edu	37	15	63000709	63000709	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:63000709C>T	uc002alb.3	+	18	2181	c.2181C>T	c.(2179-2181)AGC>AGT	p.S727S		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	727					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11																		---	---	---	---
PARP16	54956	broad.mit.edu	37	15	65553245	65553245	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65553245A>G	uc002aoo.2	-	5	1065	c.811T>C	c.(811-813)TAT>CAT	p.Y271H	PARP16_uc002aop.2_Missense_Mutation_p.Y156H|PARP16_uc002aoq.2_Missense_Mutation_p.Y271H	NM_017851	NP_060321	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	271	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			lung(2)	2																		---	---	---	---
GLCE	26035	broad.mit.edu	37	15	69561347	69561347	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69561347C>T	uc002ary.1	+	5	1846	c.1618C>T	c.(1618-1620)CGT>TGT	p.R540C		NM_015554	NP_056369	O94923	GLCE_HUMAN	D-glucuronyl C5-epimerase	540	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			ovary(2)	2																		---	---	---	---
LRRC49	54839	broad.mit.edu	37	15	71276445	71276445	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:71276445T>C	uc002asw.2	+	11	1265	c.1018T>C	c.(1018-1020)TTA>CTA	p.L340L	LRRC49_uc002asu.2_Silent_p.L330L|LRRC49_uc002asx.2_Silent_p.L296L|LRRC49_uc010ukf.1_Silent_p.L345L|LRRC49_uc002asy.2_Silent_p.L46L|LRRC49_uc002asz.2_Silent_p.L312L	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	340	Potential.					cytoplasm|microtubule				ovary(1)	1																		---	---	---	---
THSD4	79875	broad.mit.edu	37	15	72063445	72063445	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72063445C>T	uc002atb.1	+	16	2891	c.2812C>T	c.(2812-2814)CGG>TGG	p.R938W	THSD4_uc002ate.2_Missense_Mutation_p.R578W|THSD4_uc002atg.1_Missense_Mutation_p.R141W	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	938	TSP type-1 6.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2																		---	---	---	---
PKM2	5315	broad.mit.edu	37	15	72501132	72501132	+	Silent	SNP	C	T	T	rs11558356		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72501132C>T	uc002atx.1	-	6	907	c.666G>A	c.(664-666)TCG>TCA	p.S222S	PKM2_uc002ats.1_5'Flank|PKM2_uc002att.1_5'UTR|PKM2_uc002atu.1_5'UTR|PKM2_uc010bit.1_Silent_p.S227S|PKM2_uc010uki.1_Silent_p.S296S|PKM2_uc002atv.1_Silent_p.S257S|PKM2_uc002atw.1_Silent_p.S222S|PKM2_uc002aty.1_Silent_p.S222S|PKM2_uc010ukj.1_Silent_p.S207S|PKM2_uc010ukk.1_Silent_p.S148S|PKM2_uc010biu.1_Silent_p.S243S|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	222					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)													---	---	---	---
CSK	1445	broad.mit.edu	37	15	75094434	75094434	+	Intron	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75094434G>T	uc010bkb.1	+						CSK_uc002ays.2_Intron|CSK_uc010bkc.1_Intron	NM_001127190	NP_001120662			c-src tyrosine kinase						blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3																		---	---	---	---
CSPG4	1464	broad.mit.edu	37	15	75981164	75981164	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75981164G>A	uc002baw.2	-	3	2335	c.2242C>T	c.(2242-2244)CCA>TCA	p.P748S		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	748	CSPG 3.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3																		---	---	---	---
CIB2	10518	broad.mit.edu	37	15	78401632	78401632	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78401632C>T	uc002bdb.1	-	4	612	c.291G>A	c.(289-291)GTG>GTA	p.V97V	CIB2_uc002bdc.1_Silent_p.V54V|CIB2_uc010ums.1_Silent_p.V97V	NM_006383	NP_006374	O75838	CIB2_HUMAN	DNA-dependent protein kinase catalytic	97	EF-hand 1.						calcium ion binding				0																		---	---	---	---
CRABP1	1381	broad.mit.edu	37	15	78633393	78633393	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78633393G>A	uc002bdp.2	+	2	184	c.79G>A	c.(79-81)GCC>ACC	p.A27T		NM_004378	NP_004369	P29762	RABP1_HUMAN	cellular retinoic acid binding protein 1	27	Nuclear localization signal (By similarity).				multicellular organismal development|signal transduction	cytoplasm	retinal binding|retinol binding|transporter activity				0					Alitretinoin(DB00523)|Etretinate(DB00926)													---	---	---	---
AP3B2	8120	broad.mit.edu	37	15	83346060	83346060	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83346060A>T	uc010uoh.1	-	13	1631	c.1454T>A	c.(1453-1455)ATC>AAC	p.I485N	AP3B2_uc010uoi.1_Missense_Mutation_p.I485N|AP3B2_uc010uoj.1_Missense_Mutation_p.I453N|AP3B2_uc010uog.1_Missense_Mutation_p.I121N	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	485					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)															---	---	---	---
FSD2	123722	broad.mit.edu	37	15	83430979	83430979	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83430979C>A	uc002bjd.2	-	12	2039	c.1872G>T	c.(1870-1872)TGG>TGT	p.W624C	FSD2_uc010uol.1_Missense_Mutation_p.W579C|FSD2_uc010uom.1_Missense_Mutation_p.W579C	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	624	B30.2/SPRY.									central_nervous_system(1)	1																		---	---	---	---
ZNF774	342132	broad.mit.edu	37	15	90904478	90904478	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90904478C>T	uc002bpk.3	+	4	1601	c.1415C>T	c.(1414-1416)GCG>GTG	p.A472V		NM_001004309	NP_001004309	Q6NX45	ZN774_HUMAN	zinc finger protein 774	472	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)															---	---	---	---
SYNM	23336	broad.mit.edu	37	15	99670499	99670499	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:99670499G>A	uc002bup.2	+	6	2054	c.1934G>A	c.(1933-1935)AGT>AAT	p.S645N	SYNM_uc002buo.2_Missense_Mutation_p.S645N|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	645	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
MSLNL	401827	broad.mit.edu	37	16	830412	830412	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:830412C>T	uc002cjz.1	-	3	589	c.589G>A	c.(589-591)GTG>ATG	p.V197M		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:Variant_position_missing_in_Q96KJ4_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4																		---	---	---	---
TELO2	9894	broad.mit.edu	37	16	1551487	1551487	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1551487G>A	uc002cly.2	+	10	1639	c.1348G>A	c.(1348-1350)GCC>ACC	p.A450T		NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	450						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)																---	---	---	---
TELO2	9894	broad.mit.edu	37	16	1556320	1556320	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1556320C>T	uc002cly.2	+	17	2407	c.2116C>T	c.(2116-2118)CGC>TGC	p.R706C		NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	706						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)																---	---	---	---
RPL3L	6123	broad.mit.edu	37	16	2004000	2004000	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2004000C>T	uc002cnh.2	-	2	200	c.153G>A	c.(151-153)GCG>GCA	p.A51A		NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	51					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0																		---	---	---	---
TBL3	10607	broad.mit.edu	37	16	2027994	2027994	+	Missense_Mutation	SNP	G	A	A	rs147338596	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2027994G>A	uc002cnu.1	+	19	2096	c.1994G>A	c.(1993-1995)CGG>CAG	p.R665Q	TBL3_uc002cnv.1_Missense_Mutation_p.R551Q|TBL3_uc010bsb.1_Intron|TBL3_uc010bsc.1_Missense_Mutation_p.R532Q|TBL3_uc010uvt.1_Missense_Mutation_p.R134Q|TBL3_uc002cnw.1_RNA	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	665					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0																		---	---	---	---
CCDC64B	146439	broad.mit.edu	37	16	3085468	3085468	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3085468C>T	uc002ctf.3	-	1	75	c.30G>A	c.(28-30)CCG>CCA	p.P10P	CCDC64B_uc002cte.3_5'Flank	NM_001103175	NP_001096645	A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	10											0																		---	---	---	---
ZNF205	7755	broad.mit.edu	37	16	3169295	3169295	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3169295G>A	uc002cub.2	+	7	769	c.634G>A	c.(634-636)GTG>ATG	p.V212M	ZNF205_uc002cua.2_Missense_Mutation_p.V212M	NM_001042428	NP_001035893	O95201	ZN205_HUMAN	zinc finger protein 205	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0																		---	---	---	---
ZNF597	146434	broad.mit.edu	37	16	3493164	3493164	+	5'UTR	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3493164G>T	uc002cvd.2	-	2					NAT15_uc002cvh.3_5'Flank|NAT15_uc010uxb.1_5'Flank	NM_152457	NP_689670			zinc finger protein 597						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
BTBD12	84464	broad.mit.edu	37	16	3640549	3640549	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3640549C>T	uc002cvp.2	-	12	3717	c.3090G>A	c.(3088-3090)CCG>CCA	p.P1030P		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1030	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0													Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				---	---	---	---
BTBD12	84464	broad.mit.edu	37	16	3658536	3658536	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3658536G>A	uc002cvp.2	-	2	1057	c.430C>T	c.(430-432)CTT>TTT	p.L144F	BTBD12_uc002cvq.1_Missense_Mutation_p.L144F	NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	144	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0													Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				---	---	---	---
C16orf5	29965	broad.mit.edu	37	16	4562627	4562627	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4562627C>T	uc002cwu.2	-	5	868	c.573G>A	c.(571-573)ACG>ACA	p.T191T	C16orf5_uc002cwv.2_Silent_p.T191T|C16orf5_uc002cww.2_Silent_p.T191T|C16orf5_uc010uxl.1_Silent_p.T152T|C16orf5_uc010uxm.1_Silent_p.T112T|C16orf5_uc010btu.2_RNA	NM_013399	NP_037531	Q9H305	LITFL_HUMAN	cell death inducing protein	191					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|tumor necrosis factor-mediated signaling pathway	nucleus				ovary(1)	1		Ovarian(90;0.17)																---	---	---	---
MGRN1	23295	broad.mit.edu	37	16	4723609	4723609	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4723609C>T	uc002cwz.2	+	10	1042	c.906C>T	c.(904-906)TGC>TGT	p.C302C	MGRN1_uc002cxa.2_Silent_p.C302C|MGRN1_uc010btx.2_Silent_p.C303C|MGRN1_uc010btw.2_Silent_p.C303C|MGRN1_uc002cxb.2_Silent_p.C341C|MGRN1_uc010uxo.1_Silent_p.C302C|MGRN1_uc010uxp.1_Silent_p.C302C|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	302	RING-type.				endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
USP7	7874	broad.mit.edu	37	16	8987926	8987926	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:8987926C>T	uc002czl.2	-	31	3437	c.3238G>A	c.(3238-3240)GAC>AAC	p.D1080N	USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.D981N|USP7_uc002czk.2_Missense_Mutation_p.D1064N	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	1080					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3																		---	---	---	---
CIITA	4261	broad.mit.edu	37	16	11017143	11017143	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11017143C>T	uc002dai.3	+	19	3509	c.3376C>T	c.(3376-3378)CGG>TGG	p.R1126W	CIITA_uc002daj.3_Missense_Mutation_p.R1127W|CIITA_uc002dak.3_Missense_Mutation_p.R542W	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	1126					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1								T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								---	---	---	---
SNX29	92017	broad.mit.edu	37	16	12162983	12162983	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:12162983G>A	uc002dby.3	+	3	214	c.158G>A	c.(157-159)CGG>CAG	p.R53Q	SNX29_uc010uyx.1_Missense_Mutation_p.R80Q	NM_001080530	NP_001073999	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	53					cell communication		phosphatidylinositol binding			ovary(1)	1																		---	---	---	---
GPR139	124274	broad.mit.edu	37	16	20084900	20084900	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20084900C>T	uc002dgu.1	-	1	201	c.39G>A	c.(37-39)TCG>TCA	p.S13S	GPR139_uc010vaw.1_5'UTR	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	13	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)	2																		---	---	---	---
PDILT	204474	broad.mit.edu	37	16	20386166	20386166	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20386166T>A	uc002dhc.1	-	5	882	c.659A>T	c.(658-660)GAC>GTC	p.D220V		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	220					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1																		---	---	---	---
DNAH3	55567	broad.mit.edu	37	16	20974905	20974905	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20974905C>T	uc010vbe.1	-	53	10301	c.10301G>A	c.(10300-10302)GGC>GAC	p.G3434D	DNAH3_uc010vbd.1_Missense_Mutation_p.G869D	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3434					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)														---	---	---	---
EARS2	124454	broad.mit.edu	37	16	23563615	23563615	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23563615G>A	uc002dlt.3	-	2	182	c.150C>T	c.(148-150)CAC>CAT	p.H50H	EARS2_uc002dlr.3_5'Flank|EARS2_uc002dls.3_RNA|EARS2_uc002dlu.2_Silent_p.H50H	NM_001083614	NP_001077083	Q5JPH6	SYEM_HUMAN	glutamyl-tRNA synthetase 2 precursor	50	HIGH region.	ATP (By similarity).			glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding				0				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)													---	---	---	---
RBBP6	5930	broad.mit.edu	37	16	24581665	24581665	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:24581665A>C	uc002dmh.2	+	17	4694	c.3654A>C	c.(3652-3654)AAA>AAC	p.K1218N	RBBP6_uc010vcb.1_Missense_Mutation_p.K1085N|RBBP6_uc002dmi.2_Missense_Mutation_p.K1184N|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.K1051N	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1218					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)														---	---	---	---
GTF3C1	2975	broad.mit.edu	37	16	27503681	27503681	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27503681G>A	uc002dov.1	-	19	3169	c.3129C>T	c.(3127-3129)TGC>TGT	p.C1043C	GTF3C1_uc002dou.2_Silent_p.C1043C	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1043						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5																		---	---	---	---
GSG1L	146395	broad.mit.edu	37	16	27840262	27840262	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27840262G>T	uc002doz.2	-	5	763	c.678C>A	c.(676-678)TCC>TCA	p.S226S	GSG1L_uc010bya.1_Silent_p.S175S|GSG1L_uc010bxz.1_Silent_p.S71S|GSG1L_uc002doy.2_Silent_p.S71S	NM_001109763	NP_001103233	Q6UXU4	GSG1L_HUMAN	GSG1-like isoform 1	226	Helical; (Potential).					integral to membrane				ovary(1)	1																		---	---	---	---
ATP2A1	487	broad.mit.edu	37	16	28893761	28893761	+	Intron	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28893761T>C	uc002dro.1	+						uc010vct.1_Intron|ATP2A1_uc002drn.1_Intron|ATP2A1_uc002drp.1_Intron	NM_173201	NP_775293			ATPase, Ca++ transporting, fast twitch 1 isoform						apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
DOC2A	8448	broad.mit.edu	37	16	30018218	30018218	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30018218G>A	uc002dvm.2	-	8	866	c.766C>T	c.(766-768)CTG>TTG	p.L256L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|DOC2A_uc002dvl.2_Silent_p.L254L|DOC2A_uc002dvn.2_Silent_p.L256L|DOC2A_uc010vef.1_RNA|DOC2A_uc002dvo.2_Silent_p.L256L|DOC2A_uc002dvp.2_Silent_p.L256L|DOC2A_uc002dvq.2_Silent_p.L256L	NM_003586	NP_003577	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	256	C2 2.|Interaction with UNC13D.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			ovary(2)	2																		---	---	---	---
ZNF668	79759	broad.mit.edu	37	16	31073394	31073394	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31073394G>A	uc010caf.2	-	3	1212	c.855C>T	c.(853-855)TGC>TGT	p.C285C	ZNF668_uc002eao.2_Silent_p.C285C	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	285	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4																		---	---	---	---
ITGAX	3687	broad.mit.edu	37	16	31373185	31373185	+	Silent	SNP	C	T	T	rs138230749	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31373185C>T	uc002ebu.1	+	10	1108	c.1041C>T	c.(1039-1041)TTC>TTT	p.F347F	ITGAX_uc002ebt.2_Silent_p.F347F|ITGAX_uc010vfk.1_5'UTR	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	347	FG-GAP 3.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
TGFB1I1	7041	broad.mit.edu	37	16	31485238	31485238	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31485238G>A	uc002ecd.1	+	4	291	c.265G>A	c.(265-267)GGG>AGG	p.G89R	TGFB1I1_uc002ece.1_Missense_Mutation_p.G72R|TGFB1I1_uc010caq.1_5'UTR	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	89	Transcription activation (By similarity).|Interaction with PTK2 (By similarity).|Interaction with PTK2B.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0																		---	---	---	---
SLC5A2	6524	broad.mit.edu	37	16	31500366	31500366	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31500366G>T	uc002ecf.3	+	11	1465	c.1446G>T	c.(1444-1446)GAG>GAT	p.E482D	SLC5A2_uc010car.2_Intron|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	482	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1																		---	---	---	---
VPS35	55737	broad.mit.edu	37	16	46705645	46705645	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:46705645C>T	uc002eef.3	-	12	1595	c.1496G>A	c.(1495-1497)CGC>CAC	p.R499H	VPS35_uc002eed.2_Missense_Mutation_p.R320H|VPS35_uc002eee.2_Missense_Mutation_p.R460H	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	499					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)																---	---	---	---
ADCY7	113	broad.mit.edu	37	16	50347950	50347950	+	Missense_Mutation	SNP	G	A	A	rs150764665		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50347950G>A	uc002egd.1	+	22	3101	c.2833G>A	c.(2833-2835)GTC>ATC	p.V945I		NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	945	Cytoplasmic (Potential).|Guanylate cyclase 2.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)													---	---	---	---
OGFOD1	55239	broad.mit.edu	37	16	56485619	56485619	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56485619A>G	uc002ejb.2	+	1	196	c.95A>G	c.(94-96)GAA>GGA	p.E32G	OGFOD1_uc002ejc.2_Intron|NUDT21_uc002eja.2_5'Flank	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	32							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)													---	---	---	---
NUP93	9688	broad.mit.edu	37	16	56864512	56864512	+	Missense_Mutation	SNP	G	A	A	rs145578512		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56864512G>A	uc002eka.2	+	10	1121	c.1000G>A	c.(1000-1002)GCT>ACT	p.A334T	NUP93_uc002ekb.2_Missense_Mutation_p.A211T|NUP93_uc010vhi.1_Missense_Mutation_p.A211T	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	334					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2																		---	---	---	---
DOK4	55715	broad.mit.edu	37	16	57509501	57509501	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57509501G>A	uc010cdb.2	-	3	504	c.206C>T	c.(205-207)ACG>ATG	p.T69M	DOK4_uc002elu.1_Missense_Mutation_p.T69M|DOK4_uc002elv.3_Missense_Mutation_p.T69M	NM_018110	NP_060580	Q8TEW6	DOK4_HUMAN	docking protein 4	69	PH.						insulin receptor binding			skin(1)	1																		---	---	---	---
KATNB1	10300	broad.mit.edu	37	16	57789830	57789830	+	Splice_Site	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57789830G>A	uc002eml.1	+	17	2017	c.1643_splice	c.e17+1	p.A548_splice		NM_005886	NP_005877			katanin p80 subunit B 1						cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)																---	---	---	---
PRSS54	221191	broad.mit.edu	37	16	58318533	58318533	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58318533G>A	uc002enf.2	-	6	1010	c.615C>T	c.(613-615)TGC>TGT	p.C205C	PRSS54_uc002eng.2_Silent_p.C205C|PRSS54_uc010vie.1_Silent_p.C106C	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	205	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
NDRG4	65009	broad.mit.edu	37	16	58537768	58537768	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58537768C>T	uc002eno.2	+	2	194	c.88C>T	c.(88-90)CGC>TGC	p.R30C	NDRG4_uc002enk.2_Missense_Mutation_p.R62C|NDRG4_uc002enm.2_Missense_Mutation_p.R82C|NDRG4_uc010vif.1_Missense_Mutation_p.R62C|NDRG4_uc010cdk.2_Missense_Mutation_p.R30C|NDRG4_uc010vig.1_Missense_Mutation_p.R60C|NDRG4_uc010vih.1_5'UTR|NDRG4_uc010vii.1_Missense_Mutation_p.R48C|NDRG4_uc002enp.2_Missense_Mutation_p.R30C|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	30					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1																		---	---	---	---
CMTM4	146223	broad.mit.edu	37	16	66670346	66670346	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66670346G>T	uc002epz.2	-	2	507	c.325C>A	c.(325-327)CTG>ATG	p.L109M	CMTM4_uc002eqa.2_Missense_Mutation_p.L109M	NM_178818	NP_848933	Q8IZR5	CKLF4_HUMAN	chemokine-like factor superfamily 4 isoform 1	109	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			pancreas(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0811)|Epithelial(162;0.214)														---	---	---	---
B3GNT9	84752	broad.mit.edu	37	16	67183705	67183705	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67183705G>A	uc002erf.2	-	2	1005	c.684C>T	c.(682-684)GGC>GGT	p.G228G	uc002erg.1_Silent_p.S36S	NM_033309	NP_171608	Q6UX72	B3GN9_HUMAN	UDP-GlcNAc:betaGal	228	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0																		---	---	---	---
ELMO3	79767	broad.mit.edu	37	16	67235944	67235944	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67235944T>C	uc002esa.2	+	12	1317	c.1274T>C	c.(1273-1275)TTG>TCG	p.L425S	ELMO3_uc002esb.2_Missense_Mutation_p.L408S|ELMO3_uc002esc.2_Missense_Mutation_p.L259S	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	372	ELMO.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)														---	---	---	---
SLC9A5	6553	broad.mit.edu	37	16	67290816	67290816	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67290816G>A	uc002esm.2	+	7	1198	c.1135G>A	c.(1135-1137)GTA>ATA	p.V379I	SLC9A5_uc010cee.2_Missense_Mutation_p.V84I|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	379	Helical; (Potential).				regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)														---	---	---	---
PRMT7	54496	broad.mit.edu	37	16	68373230	68373230	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68373230T>A	uc002evy.1	+	8	786	c.510T>A	c.(508-510)AAT>AAA	p.N170K	PRMT7_uc002evx.1_Missense_Mutation_p.N170K|PRMT7_uc010vlg.1_Missense_Mutation_p.N120K|PRMT7_uc002evz.1_Missense_Mutation_p.N16K	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	170					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)														---	---	---	---
CHTF8	54921	broad.mit.edu	37	16	69155070	69155070	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69155070C>T	uc002ewn.1	-	3	128	c.27G>A	c.(25-27)GCG>GCA	p.A9A	CHTF8_uc002ewm.1_5'UTR|CHTF8_uc002ewo.1_5'UTR|CHTF8_uc002ewp.1_Silent_p.A9A	NM_001040146	NP_001035236	P0CG13	CTF8_HUMAN	chromosome transmission fidelity factor 8	9					cell cycle|DNA replication	nucleus	DNA binding				0																		---	---	---	---
NFAT5	10725	broad.mit.edu	37	16	69681374	69681374	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69681374C>T	uc002exm.1	+	3	1851	c.643C>T	c.(643-645)CGA>TGA	p.R215*	NFAT5_uc002exh.1_Intron|NFAT5_uc002exi.2_Nonsense_Mutation_p.R139*|NFAT5_uc002exj.1_Nonsense_Mutation_p.R139*|NFAT5_uc002exk.1_Nonsense_Mutation_p.R139*|NFAT5_uc002exl.1_Nonsense_Mutation_p.R233*|NFAT5_uc002exn.1_Nonsense_Mutation_p.R233*	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	215					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
DHX38	9785	broad.mit.edu	37	16	72141255	72141255	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72141255G>A	uc002fcb.2	+	20	2972	c.2617G>A	c.(2617-2619)GCC>ACC	p.A873T	DHX38_uc010vmp.1_Missense_Mutation_p.A185T	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	873	Helicase C-terminal.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)																---	---	---	---
ZFHX3	463	broad.mit.edu	37	16	72834006	72834006	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72834006A>G	uc002fck.2	-	8	4560	c.3887T>C	c.(3886-3888)ATG>ACG	p.M1296T	ZFHX3_uc002fcl.2_Missense_Mutation_p.M382T	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1296					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)																---	---	---	---
ZFHX3	463	broad.mit.edu	37	16	72993954	72993954	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72993954G>T	uc002fck.2	-	2	764	c.91C>A	c.(91-93)CAC>AAC	p.H31N	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	31					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)																---	---	---	---
WWOX	51741	broad.mit.edu	37	16	79245555	79245555	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:79245555G>A	uc002ffk.2	+	9	1232	c.1107G>A	c.(1105-1107)GAG>GAA	p.E369E	WWOX_uc010vnk.1_Silent_p.E256E|WWOX_uc002ffl.2_Silent_p.E189E|WWOX_uc010che.2_Missense_Mutation_p.G154R	NM_016373	NP_057457	Q9NZC7	WWOX_HUMAN	WW domain-containing oxidoreductase isoform 1	369	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity				0		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)														---	---	---	---
CDYL2	124359	broad.mit.edu	37	16	80638416	80638416	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:80638416G>A	uc002ffs.2	-	7	1495	c.1390C>T	c.(1390-1392)CGG>TGG	p.R464W		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	464						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1																		---	---	---	---
GAN	8139	broad.mit.edu	37	16	81398967	81398967	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81398967G>A	uc002fgo.2	+	9	1534	c.1386G>A	c.(1384-1386)GTG>GTA	p.V462V		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	462	Kelch 4.				cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)																---	---	---	---
TAF1C	9013	broad.mit.edu	37	16	84217343	84217343	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84217343C>T	uc002fhn.2	-	3	408	c.180G>A	c.(178-180)CCG>CCA	p.P60P	TAF1C_uc002fhm.2_5'UTR|TAF1C_uc010vnx.1_Silent_p.P60P|TAF1C_uc010vny.1_5'UTR|TAF1C_uc010vnz.1_Intron|TAF1C_uc002fho.2_Intron|TAF1C_uc010voa.1_Intron|TAF1C_uc002fhp.1_RNA|TAF1C_uc010vob.1_Silent_p.P60P	NM_005679	NP_005670	Q15572	TAF1C_HUMAN	TBP-associated factor 1C isoform 1	60					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			ovary(1)	1																		---	---	---	---
FOXF1	2294	broad.mit.edu	37	16	86544680	86544680	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:86544680A>G	uc002fjl.2	+	1	548	c.505A>G	c.(505-507)ACC>GCC	p.T169A	uc002fjk.1_5'Flank	NM_001451	NP_001442	Q12946	FOXF1_HUMAN	forkhead box F1	169					branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0																		---	---	---	---
MTHFSD	64779	broad.mit.edu	37	16	86575788	86575788	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:86575788G>A	uc002fjn.2	-	6	525	c.474C>T	c.(472-474)GCC>GCT	p.A158A	MTHFSD_uc010voo.1_Silent_p.A138A|MTHFSD_uc002fjo.2_5'UTR|MTHFSD_uc002fjm.2_Silent_p.A157A|MTHFSD_uc010vop.1_5'UTR|MTHFSD_uc010voq.1_Silent_p.A157A|MTHFSD_uc010vor.1_Silent_p.A158A|MTHFSD_uc002fjp.2_Silent_p.A138A	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	158					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0																		---	---	---	---
ZC3H18	124245	broad.mit.edu	37	16	88695190	88695190	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88695190C>T	uc002fky.2	+	16	2694	c.2494C>T	c.(2494-2496)CGC>TGC	p.R832C	ZC3H18_uc010voz.1_Missense_Mutation_p.R856C|ZC3H18_uc010chw.2_RNA|ZC3H18_uc002fkz.2_Missense_Mutation_p.R102C	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	832						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)														---	---	---	---
SNAI3	333929	broad.mit.edu	37	16	88748042	88748042	+	Missense_Mutation	SNP	C	T	T	rs45506693		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88748042C>T	uc002flj.2	-	2	225	c.157G>A	c.(157-159)GGT>AGT	p.G53S	MGC23284_uc002fli.3_Intron	NM_178310	NP_840101	Q3KNW1	SNAI3_HUMAN	snail homolog 3	53					oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.048)														---	---	---	---
GLOD4	51031	broad.mit.edu	37	17	679152	679152	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:679152G>A	uc002frv.2	-	5	390	c.314C>T	c.(313-315)ACG>ATG	p.T105M	GLOD4_uc002frt.2_Missense_Mutation_p.T34M|GLOD4_uc002fru.2_Missense_Mutation_p.T90M|GLOD4_uc010vqc.1_Missense_Mutation_p.T81M	NM_016080	NP_057164	Q9HC38	GLOD4_HUMAN	glyoxalase domain containing 4	105						mitochondrion					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)														---	---	---	---
YWHAE	7531	broad.mit.edu	37	17	1264466	1264466	+	Silent	SNP	C	T	T	rs146808095	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1264466C>T	uc002fsj.2	-	4	650	c.498G>A	c.(496-498)ACG>ACA	p.T166T	YWHAE_uc002fsk.2_Silent_p.T144T|YWHAE_uc010vqh.1_RNA|YWHAE_uc010vqi.1_Intron	NM_006761	NP_006752	P62258	1433E_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	166					apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding			lung(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)														---	---	---	---
MYO1C	4641	broad.mit.edu	37	17	1373490	1373490	+	Silent	SNP	C	T	T	rs139792172		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1373490C>T	uc002fsp.2	-	24	2725	c.2505G>A	c.(2503-2505)ACG>ACA	p.T835T	MYO1C_uc002fsn.2_Silent_p.T816T|MYO1C_uc002fso.2_Silent_p.T800T|MYO1C_uc010vqj.1_Silent_p.T800T	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	835					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
RILP	83547	broad.mit.edu	37	17	1549887	1549887	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1549887G>T	uc002ftd.2	-	8	1349	c.1055C>A	c.(1054-1056)GCT>GAT	p.A352D	SCARF1_uc002fsy.1_5'Flank|SCARF1_uc002fsz.1_5'Flank|SCARF1_uc002fta.1_5'Flank|SCARF1_uc010cjv.1_5'Flank	NM_031430	NP_113618	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	352					endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
WDR81	124997	broad.mit.edu	37	17	1637274	1637274	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1637274C>T	uc002fti.2	+	7	1523	c.1262C>T	c.(1261-1263)TCG>TTG	p.S421L	WDR81_uc002fth.2_Missense_Mutation_p.S597L|WDR81_uc010vqp.1_Missense_Mutation_p.S445L|WDR81_uc002ftj.2_Missense_Mutation_p.S1648L|WDR81_uc010vqq.1_Missense_Mutation_p.S279L	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	421										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
SRR	63826	broad.mit.edu	37	17	2222212	2222212	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2222212C>T	uc002fue.1	+	4	456	c.388C>T	c.(388-390)CCT>TCT	p.P130S	SRR_uc002fui.1_5'UTR	NM_021947	NP_068766	Q9GZT4	SRR_HUMAN	serine racemase	130					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity				0		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)													---	---	---	---
TRPV3	162514	broad.mit.edu	37	17	3432285	3432285	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3432285C>T	uc002fvt.1	-	10	1569	c.1247G>A	c.(1246-1248)CGG>CAG	p.R416Q	TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Missense_Mutation_p.R400Q|TRPV3_uc010vri.1_Missense_Mutation_p.R371Q|TRPV3_uc010vrj.1_Missense_Mutation_p.R400Q|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Missense_Mutation_p.R400Q|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Missense_Mutation_p.R416Q|TRPV3_uc002fvu.2_Missense_Mutation_p.R416Q|TRPV3_uc010vrn.1_5'UTR	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	416	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)													---	---	---	---
ATP2A3	489	broad.mit.edu	37	17	3850844	3850844	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3850844C>T	uc002fxb.1	-	8	1087	c.936G>A	c.(934-936)CCG>CCA	p.P312P	ATP2A3_uc002fwx.1_Silent_p.P312P|ATP2A3_uc002fwy.1_Silent_p.P312P|ATP2A3_uc002fwz.1_Silent_p.P312P|ATP2A3_uc002fxa.1_Silent_p.P312P|ATP2A3_uc002fxc.1_Silent_p.P312P|ATP2A3_uc002fxd.1_Silent_p.P312P	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	312	Helical; Name=4; (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)														---	---	---	---
CAMTA2	23125	broad.mit.edu	37	17	4883674	4883674	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4883674G>A	uc002gah.1	-	9	1051	c.943C>T	c.(943-945)CGA>TGA	p.R315*	CAMTA2_uc010cku.1_Nonsense_Mutation_p.R338*|CAMTA2_uc002gag.1_Nonsense_Mutation_p.R314*|CAMTA2_uc002gai.1_Nonsense_Mutation_p.R317*|CAMTA2_uc010ckv.1_5'UTR|CAMTA2_uc010vsu.1_Nonsense_Mutation_p.R128*	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	315					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1																OREG0024111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
C1QBP	708	broad.mit.edu	37	17	5337060	5337060	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5337060C>T	uc002gby.1	-	4	583	c.505G>A	c.(505-507)GTG>ATG	p.V169M		NM_001212	NP_001203	Q07021	C1QBP_HUMAN	complement component 1, q subcomponent binding	169					blood coagulation, intrinsic pathway|immune response|interspecies interaction between organisms	mitochondrial matrix|nucleus|plasma membrane				ovary(1)	1																		---	---	---	---
NLRP1	22861	broad.mit.edu	37	17	5418368	5418368	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5418368C>T	uc002gci.2	-	17	4683	c.4128G>A	c.(4126-4128)CCG>CCA	p.P1376P	NLRP1_uc002gcg.1_Intron|NLRP1_uc002gck.2_Silent_p.P1332P|NLRP1_uc002gcj.2_Silent_p.P1346P|NLRP1_uc002gcl.2_Silent_p.P1302P|NLRP1_uc002gch.3_Silent_p.P1332P	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	1376	CARD.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)																---	---	---	---
KIAA0753	9851	broad.mit.edu	37	17	6502643	6502643	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6502643A>G	uc002gde.3	-						KIAA0753_uc010vtd.1_Intron|KIAA0753_uc010clo.2_Intron|KIAA0753_uc010vte.1_Intron	NM_014804	NP_055619			hypothetical protein LOC9851							centrosome					0				COAD - Colon adenocarcinoma(228;0.157)														---	---	---	---
CHD3	1107	broad.mit.edu	37	17	7794025	7794025	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7794025G>A	uc002gje.2	+	3	500	c.350G>A	c.(349-351)CGG>CAG	p.R117Q	CHD3_uc002gjd.2_Missense_Mutation_p.R176Q|CHD3_uc002gjf.2_Missense_Mutation_p.R117Q|CHD3_uc002gjg.1_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	117					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)																---	---	---	---
CHD3	1107	broad.mit.edu	37	17	7803219	7803219	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7803219G>T	uc002gje.2	+	16	2700	c.2550G>T	c.(2548-2550)GAG>GAT	p.E850D	CHD3_uc002gjd.2_Missense_Mutation_p.E909D|CHD3_uc002gjf.2_Missense_Mutation_p.E850D	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	850	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)																---	---	---	---
ARHGEF15	22899	broad.mit.edu	37	17	8215418	8215418	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8215418C>T	uc002glc.2	+	2	182	c.61C>T	c.(61-63)CGC>TGC	p.R21C	ARHGEF15_uc002glb.1_Missense_Mutation_p.R21C|ARHGEF15_uc002gld.2_Missense_Mutation_p.R21C|ARHGEF15_uc010vuw.1_Missense_Mutation_p.R21C	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	21	Pro-rich.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3																		---	---	---	---
MYH10	4628	broad.mit.edu	37	17	8404186	8404186	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8404186T>C	uc002gll.2	-	27	3705	c.3609A>G	c.(3607-3609)ACA>ACG	p.T1203T	MYH10_uc002glm.2_Silent_p.T1234T|MYH10_uc010cnx.2_Silent_p.T1212T	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1203	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2																		---	---	---	---
RCVRN	5957	broad.mit.edu	37	17	9804356	9804356	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9804356G>A	uc002gme.1	-	2	630	c.443C>T	c.(442-444)CCG>CTG	p.P148L		NM_002903	NP_002894	P35243	RECO_HUMAN	recoverin	148	EF-hand 4.				visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity				0																		---	---	---	---
MYH8	4626	broad.mit.edu	37	17	10301751	10301751	+	Intron	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10301751C>A	uc002gmm.2	-						uc002gml.1_Intron	NM_002472	NP_002463			myosin, heavy chain 8, skeletal muscle,						muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11														Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				---	---	---	---
DNAH9	1770	broad.mit.edu	37	17	11648122	11648122	+	Silent	SNP	C	T	T	rs138108837	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:11648122C>T	uc002gne.2	+	31	6188	c.6120C>T	c.(6118-6120)TAC>TAT	p.Y2040Y	DNAH9_uc010coo.2_Silent_p.Y1334Y	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2040	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)														---	---	---	---
MAP2K4	6416	broad.mit.edu	37	17	12016623	12016623	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12016623G>A	uc002gnj.2	+	7	828	c.759G>A	c.(757-759)CAG>CAA	p.Q253Q	MAP2K4_uc002gnk.2_Silent_p.Q264Q|MAP2K4_uc010vvi.1_Silent_p.Q135Q|MAP2K4_uc010vvj.1_Silent_p.Q125Q	NM_003010	NP_003001	P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	253	Protein kinase.				cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.?(1)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)				D|Mis|N		pancreatic|breast|colorectal								---	---	---	---
MAP2K4	6416	broad.mit.edu	37	17	12028690	12028690	+	Splice_Site	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12028690T>C	uc002gnj.2	+	8	960	c.891_splice	c.e8+2	p.L297_splice	MAP2K4_uc002gnk.2_Splice_Site_p.L308_splice|MAP2K4_uc010vvi.1_Splice_Site_p.L179_splice|MAP2K4_uc010vvj.1_Splice_Site_p.L169_splice	NM_003010	NP_003001			mitogen-activated protein kinase kinase 4						cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.?(1)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)				D|Mis|N		pancreatic|breast|colorectal								---	---	---	---
COX10	1352	broad.mit.edu	37	17	14110390	14110390	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:14110390C>T	uc002gof.3	+	7	1396	c.1192C>T	c.(1192-1194)CGC>TGC	p.R398C	COX10_uc010vvs.1_Missense_Mutation_p.R181C|COX10_uc010vvt.1_Missense_Mutation_p.R206C	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	398					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)														---	---	---	---
C17orf76	388341	broad.mit.edu	37	17	16365691	16365691	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:16365691T>C	uc010cph.1	-	2	432	c.256A>G	c.(256-258)ATG>GTG	p.M86V	C17orf76_uc002gqh.2_Missense_Mutation_p.M86V|NCRNA00188_uc010vwl.1_Intron|NCRNA00188_uc010vwm.1_Intron|NCRNA00188_uc010vwn.1_Intron|NCRNA00188_uc010cpe.2_Intron|NCRNA00188_uc010vwo.1_Intron|NCRNA00188_uc010vwp.1_Intron	NM_001113567	NP_001107039	Q8NAA5	CQ076_HUMAN	hypothetical protein LOC388341 isoform 1	86											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)														---	---	---	---
MYO15A	51168	broad.mit.edu	37	17	18062941	18062941	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18062941A>G	uc010vxh.1	+	54	9589	c.9251A>G	c.(9250-9252)GAT>GGT	p.D3084G	MYO15A_uc010vxi.1_Missense_Mutation_p.D348G|MYO15A_uc010vxk.1_Intron|MYO15A_uc010vxl.1_Missense_Mutation_p.D73G|MYO15A_uc002gsl.2_Missense_Mutation_p.D6G|MYO15A_uc010vxm.1_Missense_Mutation_p.D6G|MYO15A_uc002gsm.1_5'Flank|MYO15A_uc010cpv.2_5'Flank	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3084	Tail.|MyTH4 2.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)																	---	---	---	---
SMCR8	140775	broad.mit.edu	37	17	18219725	18219725	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18219725G>A	uc002gsy.3	+	1	1132	c.622G>A	c.(622-624)GTG>ATG	p.V208M		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	208										central_nervous_system(1)	1																		---	---	---	---
FBXW10	10517	broad.mit.edu	37	17	18653319	18653319	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18653319C>T	uc002guk.2	+						FBXW10_uc002guj.2_Intron|FBXW10_uc002gul.2_Missense_Mutation_p.P319S|FBXW10_uc010cqh.1_Intron	NM_031456	NP_113644			F-box and WD-40 domain protein 10											ovary(1)	1																		---	---	---	---
ALDH3A1	218	broad.mit.edu	37	17	19643645	19643645	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:19643645G>A	uc010cqu.2	-						ALDH3A1_uc010vzd.1_Intron|ALDH3A1_uc002gwj.2_Intron|ALDH3A1_uc010cqv.2_Intron|ALDH3A1_uc002gwk.2_Intron|ALDH3A1_uc002gwl.1_Intron	NM_001135168	NP_001128640			aldehyde dehydrogenase 3A1						cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)													---	---	---	---
AKAP10	11216	broad.mit.edu	37	17	19839741	19839741	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:19839741T>C	uc002gwo.2	-	9	1462	c.1325A>G	c.(1324-1326)TAC>TGC	p.Y442C	AKAP10_uc002gwp.1_Missense_Mutation_p.Y442C|AKAP10_uc010cqw.1_Missense_Mutation_p.Y442C	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	442	RGS 2.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)																	---	---	---	---
FAM27L	284123	broad.mit.edu	37	17	21826146	21826146	+	RNA	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:21826146C>T	uc002gyz.2	+	2		c.256C>T				NR_028336				Homo sapiens family with sequence similarity 27-like, mRNA (cDNA clone MGC:35151 IMAGE:5169482), complete cds.												0				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)														---	---	---	---
SUPT6H	6830	broad.mit.edu	37	17	27016406	27016406	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27016406C>T	uc002hby.2	+	25	3259	c.3169C>T	c.(3169-3171)CGT>TGT	p.R1057C	SUPT6H_uc010crt.2_Missense_Mutation_p.R1057C|SUPT6H_uc002hbz.1_5'UTR	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1057					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)																	---	---	---	---
RAB34	83871	broad.mit.edu	37	17	27042506	27042506	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27042506G>T	uc002hce.2	-	6	1023	c.399C>A	c.(397-399)AAC>AAA	p.N133K	RAB34_uc002hcg.2_Missense_Mutation_p.N133K|RAB34_uc002hcf.2_Missense_Mutation_p.N134K|RAB34_uc010was.1_Missense_Mutation_p.N190K|RAB34_uc010wat.1_Missense_Mutation_p.N190K|RAB34_uc002hch.2_Missense_Mutation_p.N133K|RAB34_uc010wau.1_Missense_Mutation_p.N111K|RAB34_uc010wav.1_Missense_Mutation_p.N191K	NM_031934	NP_114140	Q9BZG1	RAB34_HUMAN	Ras-related protein RAB34 isoform 1	133					protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	Lung NSC(42;0.00431)																	---	---	---	---
C17orf79	55352	broad.mit.edu	37	17	30183884	30183884	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30183884C>T	uc002hgp.2	-	2	208	c.100G>A	c.(100-102)GCT>ACT	p.A34T	C17orf79_uc010css.2_RNA	NM_018405	NP_060875	Q9NQ92	COPR5_HUMAN	chromosome 17 open reading frame 79	34					histone H4-R3 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding				0		all_cancers(10;4.54e-07)|all_hematologic(16;0.0216)|Acute lymphoblastic leukemia(14;0.0255)|Myeloproliferative disorder(56;0.0393)|Ovarian(249;0.1)																---	---	---	---
MYO1D	4642	broad.mit.edu	37	17	31048090	31048090	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:31048090G>A	uc002hho.1	-	15	1876	c.1864C>T	c.(1864-1866)CGT>TGT	p.R622C	MYO1D_uc002hhp.1_Missense_Mutation_p.R622C	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	622	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)															---	---	---	---
AP2B1	163	broad.mit.edu	37	17	33954650	33954650	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33954650G>A	uc002hjr.2	+	9	1249	c.1060G>A	c.(1060-1062)GTT>ATT	p.V354I	AP2B1_uc002hjq.2_Missense_Mutation_p.V354I|AP2B1_uc010wci.1_Missense_Mutation_p.V316I|AP2B1_uc002hjs.2_Missense_Mutation_p.V297I|AP2B1_uc002hjt.2_Missense_Mutation_p.V354I|AP2B1_uc010ctv.2_Missense_Mutation_p.V354I|AP2B1_uc010wcj.1_Missense_Mutation_p.V91I	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	354					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)														---	---	---	---
C17orf66	256957	broad.mit.edu	37	17	34182245	34182245	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34182245C>A	uc002hke.1	-	15	1684	c.1535G>T	c.(1534-1536)CGA>CTA	p.R512L	C17orf66_uc010wck.1_RNA|C17orf66_uc010wcl.1_Missense_Mutation_p.R472L	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957	512							binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)														---	---	---	---
ACACA	31	broad.mit.edu	37	17	35486328	35486328	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35486328G>A	uc002hnm.2	-	47	5987	c.5796C>T	c.(5794-5796)TAC>TAT	p.Y1932Y	ACACA_uc002hnk.2_Silent_p.Y1854Y|ACACA_uc002hnl.2_Silent_p.Y1874Y|ACACA_uc002hnn.2_Silent_p.Y1932Y|ACACA_uc002hno.2_Silent_p.Y1969Y|ACACA_uc010cuy.2_Silent_p.Y577Y|ACACA_uc010wdc.1_Silent_p.Y58Y	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1932	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
ACACA	31	broad.mit.edu	37	17	35601498	35601498	+	Intron	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35601498A>G	uc002hnm.2	-						ACACA_uc002hnk.2_Intron|ACACA_uc002hnl.2_Intron|ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc010cuz.2_Intron	NM_198836	NP_942133			acetyl-Coenzyme A carboxylase alpha isoform 2						acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
SOCS7	30837	broad.mit.edu	37	17	36533673	36533673	+	Intron	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36533673G>T	uc002hqa.2	+						SOCS7_uc010cvl.2_Intron|SOCS7_uc002hqb.2_Intron	NM_014598	NP_055413			suppressor of cytokine signaling 7						intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)																	---	---	---	---
MLLT6	4302	broad.mit.edu	37	17	36861965	36861965	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36861965G>T	uc002hqi.3	+	1	93	c.80G>T	c.(79-81)GGG>GTG	p.G27V	MLLT6_uc010wdr.1_Missense_Mutation_p.G27V|MLLT6_uc010cvm.1_Missense_Mutation_p.G27V	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	27	PHD-type 1.				regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)							T	MLL	AL								---	---	---	---
PCGF2	7703	broad.mit.edu	37	17	36896593	36896593	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36896593G>A	uc002hqp.1	-	3	306	c.63C>T	c.(61-63)TGC>TGT	p.C21C	PCGF2_uc002hqn.1_Silent_p.C21C|PCGF2_uc002hqo.1_Silent_p.C21C|PCGF2_uc010cvo.1_Intron|PCGF2_uc002hqq.1_Silent_p.C21C	NM_007144	NP_009075	P35227	PCGF2_HUMAN	ring finger protein 110	21	RING-type.				negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2	Breast(7;9.07e-22)																	---	---	---	---
ZPBP2	124626	broad.mit.edu	37	17	38026975	38026975	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38026975T>A	uc002hte.2	+	3	300	c.147T>A	c.(145-147)AAT>AAA	p.N49K	ZPBP2_uc002htf.2_Missense_Mutation_p.N27K	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	49					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)															---	---	---	---
SMARCE1	6605	broad.mit.edu	37	17	38793825	38793825	+	Splice_Site	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38793825C>A	uc002hux.2	-	5	281	c.157_splice	c.e5-1	p.A53_splice	SMARCE1_uc010wff.1_Splice_Site_p.A18_splice|SMARCE1_uc010wfg.1_Splice_Site|SMARCE1_uc002huy.2_Splice_Site_p.A18_splice|SMARCE1_uc010wfh.1_Splice_Site|SMARCE1_uc010wfi.1_Splice_Site_p.A35_splice|SMARCE1_uc002huz.1_Splice_Site_p.A18_splice|SMARCE1_uc010wfj.1_Splice_Site_p.A35_splice	NM_003079	NP_003070			SWI/SNF-related matrix-associated						chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)																---	---	---	---
KRT27	342574	broad.mit.edu	37	17	38935850	38935850	+	Silent	SNP	G	A	A	rs116084493	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38935850G>A	uc002hvg.2	-	5	917	c.876C>T	c.(874-876)GAC>GAT	p.D292D		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	292	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)																---	---	---	---
KRT27	342574	broad.mit.edu	37	17	38938700	38938700	+	Missense_Mutation	SNP	C	T	T	rs139116362	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38938700C>T	uc002hvg.2	-	1	87	c.46G>A	c.(46-48)GGG>AGG	p.G16R		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	16	Head.|Gly-rich.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)																---	---	---	---
KRTAP3-3	85293	broad.mit.edu	37	17	39150246	39150246	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39150246G>A	uc002hvr.1	-	1	140	c.104C>T	c.(103-105)ACC>ATC	p.T35I		NM_033185	NP_149441	Q9BYR6	KRA33_HUMAN	keratin associated protein 3-3	35	3 X 5 AA repeats of C-C-X(3).					keratin filament	structural molecule activity				0		Breast(137;0.00043)																---	---	---	---
KRTAP4-1	85285	broad.mit.edu	37	17	39340883	39340883	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39340883C>T	uc002hwe.3	-	1	265	c.224G>A	c.(223-225)CGC>CAC	p.R75H	KRTAP4-1_uc010cxm.1_RNA	NM_033060	NP_149049	Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	75	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)															---	---	---	---
KRT38	8687	broad.mit.edu	37	17	39596889	39596889	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39596889A>G	uc002hwq.1	-	1	708	c.285T>C	c.(283-285)TAT>TAC	p.Y95Y		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	95	Head.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)																---	---	---	---
KRT38	8687	broad.mit.edu	37	17	39596907	39596907	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39596907A>G	uc002hwq.1	-	1	690	c.267T>C	c.(265-267)ATT>ATC	p.I89I		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	89	Head.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)																---	---	---	---
KRT15	3866	broad.mit.edu	37	17	39674627	39674627	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39674627G>A	uc002hwy.2	-	1	644	c.453C>T	c.(451-453)TGC>TGT	p.C151C	KRT15_uc002hwz.2_Missense_Mutation_p.A14V|KRT15_uc002hxa.2_Missense_Mutation_p.A14V|KRT15_uc002hxb.1_Missense_Mutation_p.A14V	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	151	Rod.|Linker 1.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)																---	---	---	---
KLHL11	55175	broad.mit.edu	37	17	40011390	40011390	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40011390C>T	uc002hyf.1	-	2	735	c.729G>A	c.(727-729)ACG>ACA	p.T243T		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	kelch-like 11 precursor	243	BACK.					extracellular region					0		Breast(137;0.00156)																---	---	---	---
DHX58	79132	broad.mit.edu	37	17	40253855	40253855	+	Missense_Mutation	SNP	C	T	T	rs117253612	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40253855C>T	uc002hyw.3	-	14	2184	c.1961G>A	c.(1960-1962)CGC>CAC	p.R654H	DHX58_uc002hyv.3_RNA	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	654	RNA-binding.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)												OREG0024418	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
STAT5B	6777	broad.mit.edu	37	17	40371806	40371806	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40371806G>A	uc002hzh.2	-	6	774	c.605C>T	c.(604-606)ACG>ATG	p.T202M	STAT5B_uc002hzi.3_Missense_Mutation_p.T202M	NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	202					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)													---	---	---	---
STAT5A	6776	broad.mit.edu	37	17	40459717	40459717	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40459717A>G	uc002hzj.1	+	16	2524	c.1882A>G	c.(1882-1884)ACC>GCC	p.T628A	STAT5A_uc010cya.1_Missense_Mutation_p.T628A|STAT5A_uc010cyb.1_Missense_Mutation_p.T597A|STAT5A_uc010cyc.1_Missense_Mutation_p.T598A|STAT5A_uc010cyd.1_Missense_Mutation_p.T116A|STAT5A_uc010cye.1_Missense_Mutation_p.T116A	NM_003152	NP_003143	P42229	STA5A_HUMAN	signal transducer and activator of transcription	628	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)														---	---	---	---
BRCA1	672	broad.mit.edu	37	17	41246445	41246445	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41246445T>C	uc002icq.2	-	10	1335	c.1103A>G	c.(1102-1104)GAA>GGA	p.E368G	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.E297G|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.E321G|BRCA1_uc002ict.2_Missense_Mutation_p.E368G|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.E368G|BRCA1_uc002ide.1_Missense_Mutation_p.E199G|BRCA1_uc010cyy.1_Missense_Mutation_p.E368G|BRCA1_uc010whs.1_Missense_Mutation_p.E368G|BRCA1_uc010cyz.2_Missense_Mutation_p.E321G|BRCA1_uc010cza.2_Missense_Mutation_p.E342G|BRCA1_uc010wht.1_Missense_Mutation_p.E72G	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	368					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)				D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			---	---	---	---
MPP3	4356	broad.mit.edu	37	17	41908667	41908667	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41908667T>C	uc002iei.3	-	5	333	c.167A>G	c.(166-168)TAT>TGT	p.Y56C	MPP3_uc002ieh.2_Missense_Mutation_p.Y81C|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Missense_Mutation_p.Y56C|MPP3_uc010wik.1_Missense_Mutation_p.Y81C|MPP3_uc010czj.1_Missense_Mutation_p.Y56C	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	56	L27 1.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)														---	---	---	---
SLC25A39	51629	broad.mit.edu	37	17	42397752	42397752	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42397752A>G	uc002ign.2	-	10	1008	c.854T>C	c.(853-855)GTC>GCC	p.V285A	SLC25A39_uc002igm.2_Missense_Mutation_p.V277A|SLC25A39_uc002igo.2_Missense_Mutation_p.V277A|SLC25A39_uc010wiw.1_Missense_Mutation_p.V262A|SLC25A39_uc010czu.2_Missense_Mutation_p.V153A	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	285	Solcar 3.				heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)														---	---	---	---
GPATCH8	23131	broad.mit.edu	37	17	42475537	42475537	+	Missense_Mutation	SNP	G	A	A	rs34826608		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42475537G>A	uc002igw.1	-	8	3972	c.3908C>T	c.(3907-3909)GCC>GTC	p.A1303V	GPATCH8_uc002igv.1_Missense_Mutation_p.A1225V|GPATCH8_uc010wiz.1_Missense_Mutation_p.A1225V	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1303						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)														---	---	---	---
GPATCH8	23131	broad.mit.edu	37	17	42476193	42476193	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42476193G>A	uc002igw.1	-	8	3316	c.3252C>T	c.(3250-3252)GAC>GAT	p.D1084D	GPATCH8_uc002igv.1_Silent_p.D1006D|GPATCH8_uc010wiz.1_Silent_p.D1006D	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1084						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)														---	---	---	---
PLEKHM1	9842	broad.mit.edu	37	17	43531400	43531400	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43531400G>A	uc002ija.2	-	7	1988	c.1818C>T	c.(1816-1818)CGC>CGT	p.R606R	PLEKHM1_uc010wjm.1_Silent_p.R578R|PLEKHM1_uc002ijb.2_Silent_p.R81R|PLEKHM1_uc010wjn.1_Silent_p.R555R|PLEKHM1_uc002ijc.2_Silent_p.R60R	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	606	PH 1.				intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)																	---	---	---	---
PLEKHM1	9842	broad.mit.edu	37	17	43553069	43553069	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43553069T>C	uc002ija.2	-	4	490	c.320A>G	c.(319-321)CAC>CGC	p.H107R	PLEKHM1_uc010wjm.1_Missense_Mutation_p.H79R|PLEKHM1_uc002ijb.2_5'UTR|PLEKHM1_uc010wjn.1_Missense_Mutation_p.H56R|hsa-mir-4315-1|MI0015844_5'Flank	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	107	RUN.				intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)																	---	---	---	---
CRHR1	1394	broad.mit.edu	37	17	43906680	43906680	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43906680C>T	uc010dap.2	+	5	692	c.427C>T	c.(427-429)CGG>TGG	p.R143W	CRHR1_uc010wjx.1_5'UTR|CRHR1_uc002ijp.2_Missense_Mutation_p.R42W|CRHR1_uc002ijm.2_Missense_Mutation_p.R143W|CRHR1_uc002ijn.2_Missense_Mutation_p.R103W|CRHR1_uc010dar.2_Missense_Mutation_p.R143W|CRHR1_uc010dao.2_Missense_Mutation_p.R42W|CRHR1_uc010daq.2_5'UTR|CRHR1_uc010das.1_RNA|CRHR1_uc002ijo.1_RNA	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	143	Cytoplasmic (Potential).				female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(3)	3	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)														---	---	---	---
ITGB3	3690	broad.mit.edu	37	17	45377889	45377889	+	Silent	SNP	C	T	T	rs112717328	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45377889C>T	uc002ilj.2	+	12	1979	c.1959C>T	c.(1957-1959)GAC>GAT	p.D653D	ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	653	Extracellular (Potential).			GALHD -> EPYMT (in Ref. 1; AAA52589, 2; AAA60122 and 4; AAB71380).	activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)													---	---	---	---
UBE2Z	65264	broad.mit.edu	37	17	47004503	47004503	+	3'UTR	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47004503C>A	uc002ioi.2	+	7						NM_023079	NP_075567			ubiquitin-conjugating enzyme E2Z						apoptosis	cytoplasm|nucleus	ATP binding|ubiquitin-protein ligase activity				0																		---	---	---	---
NGFR	4804	broad.mit.edu	37	17	47587858	47587858	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47587858C>A	uc002ioz.3	+	4	778	c.653C>A	c.(652-654)CCT>CAT	p.P218H		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	218	Ser/Thr-rich.|Extracellular (Potential).				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)																	---	---	---	---
XYLT2	64132	broad.mit.edu	37	17	48433494	48433494	+	Missense_Mutation	SNP	G	A	A	rs139052712		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48433494G>A	uc002iqo.2	+	7	1463	c.1354G>A	c.(1354-1356)GTG>ATG	p.V452M	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	452	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)																	---	---	---	---
XYLT2	64132	broad.mit.edu	37	17	48435836	48435836	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48435836C>T	uc002iqo.2	+	10	2319	c.2210C>T	c.(2209-2211)CCG>CTG	p.P737L	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	737	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)																	---	---	---	---
RSAD1	55316	broad.mit.edu	37	17	48561095	48561095	+	Missense_Mutation	SNP	C	T	T	rs148371199		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48561095C>T	uc002iqw.1	+	7	1137	c.1081C>T	c.(1081-1083)CGC>TGC	p.R361C	RSAD1_uc010wmq.1_Intron	NM_018346	NP_060816	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing	361					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)															---	---	---	---
SPAG9	9043	broad.mit.edu	37	17	49098699	49098699	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:49098699C>T	uc002itc.2	-	7	1020	c.811G>A	c.(811-813)GGA>AGA	p.G271R	SPAG9_uc002itb.2_Missense_Mutation_p.G257R|SPAG9_uc002itd.2_Missense_Mutation_p.G257R|SPAG9_uc002itf.2_Missense_Mutation_p.G92R|SPAG9_uc002ita.2_Missense_Mutation_p.G114R|SPAG9_uc002ite.2_Missense_Mutation_p.G101R	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	271					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)															---	---	---	---
NME1-NME2	654364	broad.mit.edu	37	17	49247316	49247316	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:49247316G>A	uc002itk.2	+	8	920	c.667G>A	c.(667-669)GTG>ATG	p.V223M	NME1-NME2_uc002itj.2_Missense_Mutation_p.V198M|NME2_uc002itl.2_Missense_Mutation_p.V83M|NME2_uc002itm.2_Missense_Mutation_p.V83M|NME2_uc002itn.2_Missense_Mutation_p.V83M|NME2_uc002ito.2_Missense_Mutation_p.V83M	NM_002512	NP_002503	P22392	NDKB_HUMAN	nucleoside diphosphate kinase B	83					cell adhesion|CTP biosynthetic process|GTP biosynthetic process|negative regulation of apoptosis|nucleobase, nucleoside and nucleotide interconversion|positive regulation of epithelial cell proliferation|positive regulation of keratinocyte differentiation|UTP biosynthetic process	cytosol|lamellipodium|nucleus|ruffle	ATP binding|DNA binding|metal ion binding|nucleoside diphosphate kinase activity|protein binding|protein histidine kinase activity|sequence-specific DNA binding transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)															---	---	---	---
KIF2B	84643	broad.mit.edu	37	17	51900915	51900915	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:51900915G>A	uc002iua.2	+	1	677	c.521G>A	c.(520-522)CGC>CAC	p.R174H	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	174	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8																		---	---	---	---
MPO	4353	broad.mit.edu	37	17	56348170	56348170	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56348170G>T	uc002ivu.1	-	12	2262	c.2085C>A	c.(2083-2085)GCC>GCA	p.A695A		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	695					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)													---	---	---	---
MTMR4	9110	broad.mit.edu	37	17	56584616	56584616	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56584616G>A	uc002iwj.2	-	9	840	c.730C>T	c.(730-732)CGC>TGC	p.R244C		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	244	Myotubularin phosphatase.					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
C17orf47	284083	broad.mit.edu	37	17	56620624	56620624	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56620624G>A	uc002iwq.1	-	1	1060	c.924C>T	c.(922-924)TCC>TCT	p.S308S	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	308										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
CLTC	1213	broad.mit.edu	37	17	57760780	57760780	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57760780G>A	uc002ixq.1	+	26	4517	c.4074G>A	c.(4072-4074)TGG>TGA	p.W1358*	CLTC_uc002ixp.2_Nonsense_Mutation_p.W1358*|CLTC_uc002ixr.1_Nonsense_Mutation_p.W1362*	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	1358	Heavy chain arm.|Proximal segment.|Involved in binding clathrin light chain (By similarity).				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)							T	ALK|TFE3	ALCL|renal 								---	---	---	---
USP32	84669	broad.mit.edu	37	17	58343335	58343335	+	Splice_Site	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58343335A>G	uc002iyo.1	-	8	1213	c.927_splice	c.e8+1	p.P309_splice	USP32_uc010wov.1_Splice_Site_p.P309_splice	NM_032582	NP_115971			ubiquitin specific protease 32						protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)															---	---	---	---
TBX4	9496	broad.mit.edu	37	17	59560552	59560552	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:59560552C>T	uc002izi.2	+	8	1358	c.1313C>T	c.(1312-1314)CCG>CTG	p.P438L	TBX4_uc010ddo.2_Missense_Mutation_p.P439L|TBX4_uc010woy.1_Missense_Mutation_p.P439L	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	438					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2																		---	---	---	---
MED13	9969	broad.mit.edu	37	17	60059688	60059688	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60059688G>A	uc002izo.2	-	16	3753	c.3676C>T	c.(3676-3678)CGT>TGT	p.R1226C		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1226					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
TANC2	26115	broad.mit.edu	37	17	61466684	61466684	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61466684A>G	uc002jal.3	+	15	2631	c.2608A>G	c.(2608-2610)ATT>GTT	p.I870V	TANC2_uc010wpe.1_Missense_Mutation_p.I780V|TANC2_uc002jan.1_Missense_Mutation_p.I21V|TANC2_uc002jao.3_5'UTR|TANC2_uc002jam.1_Missense_Mutation_p.I237V	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	870	ANK 1.						binding			ovary(2)	2																		---	---	---	---
KCNH6	81033	broad.mit.edu	37	17	61611294	61611294	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61611294G>A	uc002jay.2	+	5	803	c.723G>A	c.(721-723)GCG>GCA	p.A241A	KCNH6_uc002jax.1_Silent_p.A241A|KCNH6_uc010wpl.1_Silent_p.A118A|KCNH6_uc010wpm.1_Silent_p.A241A|KCNH6_uc002jaz.1_Silent_p.A241A	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	241	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)													---	---	---	---
MAP3K3	4215	broad.mit.edu	37	17	61710073	61710073	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61710073G>A	uc002jbg.2	+	2	356	c.37G>A	c.(37-39)GAT>AAT	p.D13N	MAP3K3_uc002jbe.2_Missense_Mutation_p.D13N|MAP3K3_uc002jbf.2_Missense_Mutation_p.D13N|MAP3K3_uc002jbh.2_Missense_Mutation_p.D13N|MAP3K3_uc010wpo.1_5'UTR|MAP3K3_uc010wpp.1_Missense_Mutation_p.D13N	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	13					MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6																		---	---	---	---
PSMC5	5705	broad.mit.edu	37	17	61908237	61908237	+	Silent	SNP	G	A	A	rs138950745	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61908237G>A	uc002jcb.2	+	7	662	c.621G>A	c.(619-621)ACG>ACA	p.T207T	PSMC5_uc010ddy.2_Silent_p.T184T|PSMC5_uc010ddz.2_Silent_p.T128T|PSMC5_uc002jcc.2_Silent_p.T199T|PSMC5_uc002jcd.2_Silent_p.T199T	NM_002805	NP_002796	P62195	PRS8_HUMAN	proteasome 26S ATPase subunit 5	207					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of programmed cell death|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|thyrotropin-releasing hormone receptor binding|transcription cofactor activity|transcription factor binding			large_intestine(1)	1																		---	---	---	---
CSHL1	1444	broad.mit.edu	37	17	61987659	61987659	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61987659G>A	uc002jda.1	-	4	396	c.334C>T	c.(334-336)CTG>TTG	p.L112L	CSHL1_uc002jcz.1_Silent_p.L89L|CSHL1_uc002jdb.1_Silent_p.L18L|CSHL1_uc002jdc.1_Silent_p.L29L|CSHL1_uc002jdd.1_Silent_p.L50L|CSHL1_uc002jde.2_3'UTR|CSHL1_uc002jdf.2_Silent_p.L29L|CSHL1_uc002jdg.2_3'UTR|CSHL1_uc002jdh.2_Silent_p.L18L	NM_022579	NP_072101	Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	112						extracellular region	hormone activity|metal ion binding				0																		---	---	---	---
APOH	350	broad.mit.edu	37	17	64216830	64216830	+	Missense_Mutation	SNP	G	A	A	rs113544357		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:64216830G>A	uc002jfn.3	-	5	505	c.446C>T	c.(445-447)ACG>ATG	p.T149M		NM_000042	NP_000033	P02749	APOH_HUMAN	apolipoprotein H precursor	149	Sushi 3.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding				0			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)															---	---	---	---
PITPNC1	26207	broad.mit.edu	37	17	65628318	65628318	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65628318C>T	uc002jgc.2	+	6	773	c.426C>T	c.(424-426)TGC>TGT	p.C142C	PITPNC1_uc002jgb.2_Silent_p.C142C	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	142					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)															---	---	---	---
KPNA2	3838	broad.mit.edu	37	17	66039402	66039402	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66039402C>T	uc002jgk.2	+	7	985	c.853C>T	c.(853-855)CGA>TGA	p.R285*	KPNA2_uc002jgl.2_Nonsense_Mutation_p.R285*	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	285	ARM 6.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
ABCA8	10351	broad.mit.edu	37	17	66924149	66924149	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66924149C>T	uc002jhp.2	-	9	1360	c.1181G>A	c.(1180-1182)GGC>GAC	p.G394D	ABCA8_uc002jhq.2_Missense_Mutation_p.G394D|ABCA8_uc010wqq.1_Missense_Mutation_p.G394D|ABCA8_uc010wqr.1_Missense_Mutation_p.G333D|ABCA8_uc002jhr.2_Missense_Mutation_p.G394D	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	394						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)																	---	---	---	---
KIAA0195	9772	broad.mit.edu	37	17	73491708	73491708	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73491708C>T	uc002jnz.3	+	22	3203	c.2928C>T	c.(2926-2928)ACC>ACT	p.T976T	KIAA0195_uc010wsa.1_Silent_p.T986T|KIAA0195_uc010wsb.1_Silent_p.T616T|KIAA0195_uc002job.3_5'UTR	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	976					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
TRIM65	201292	broad.mit.edu	37	17	73888555	73888555	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73888555C>A	uc002jpx.2	-	3	573	c.537G>T	c.(535-537)TGG>TGT	p.W179C		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	179	Potential.					intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
FBF1	85302	broad.mit.edu	37	17	73919411	73919411	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73919411A>G	uc002jqc.2	-	13	1509	c.1235T>C	c.(1234-1236)CTG>CCG	p.L412P	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.L403P|FBF1_uc002jqd.1_Missense_Mutation_p.L413P|FBF1_uc010dgr.1_5'Flank	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	412											0																		---	---	---	---
ACOX1	51	broad.mit.edu	37	17	73947496	73947496	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73947496C>A	uc002jqf.2	-	8	1397	c.1107G>T	c.(1105-1107)GAG>GAT	p.E369D	ACOX1_uc010wsq.1_Missense_Mutation_p.E331D|ACOX1_uc002jqe.2_Missense_Mutation_p.E369D|ACOX1_uc010wsr.1_Missense_Mutation_p.E301D	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	369					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1																		---	---	---	---
CCDC40	55036	broad.mit.edu	37	17	78023884	78023884	+	Silent	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78023884C>A	uc010dht.2	+	7	988	c.961C>A	c.(961-963)CGA>AGA	p.R321R	CCDC40_uc010wub.1_Silent_p.R321R|CCDC40_uc002jxm.3_Silent_p.R104R	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	321					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)															---	---	---	---
RPTOR	57521	broad.mit.edu	37	17	78796110	78796110	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78796110C>T	uc002jyt.1	+						RPTOR_uc002jys.2_Intron|RPTOR_uc010wuf.1_Intron|RPTOR_uc010wug.1_Intron	NM_020761	NP_065812			raptor isoform 1						cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6																		---	---	---	---
C17orf70	80233	broad.mit.edu	37	17	79508401	79508401	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79508401G>A	uc002kaq.2	-	8	2503	c.2448C>T	c.(2446-2448)GCC>GCT	p.A816A	C17orf70_uc002kao.1_Silent_p.A465A|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Silent_p.A665A	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	816					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)															---	---	---	---
C17orf70	80233	broad.mit.edu	37	17	79517607	79517607	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79517607C>T	uc002kaq.2	-	3	968	c.913G>A	c.(913-915)GAG>AAG	p.E305K	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Missense_Mutation_p.E154K	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	305					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)															---	---	---	---
RAC3	5881	broad.mit.edu	37	17	79991663	79991663	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79991663G>A	uc002kdf.2	+	6	643	c.537G>A	c.(535-537)CCG>CCA	p.P179P		NM_005052	NP_005043	P60763	RAC3_HUMAN	ras-related C3 botulinum toxin substrate 3 (rho	179					actin cytoskeleton organization|cell projection assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endomembrane system|filamentous actin|growth cone|lamellipodium|neuronal cell body|plasma membrane	GTP binding|GTPase activity|protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)															---	---	---	---
DUS1L	64118	broad.mit.edu	37	17	80017938	80017938	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80017938C>T	uc002kdq.2	-	10	1473	c.1054G>A	c.(1054-1056)GCG>ACG	p.A352T	DUS1L_uc002kdp.2_Missense_Mutation_p.A221T|DUS1L_uc002kdr.2_Missense_Mutation_p.A352T|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	352					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)															---	---	---	---
EPB41L3	23136	broad.mit.edu	37	18	5443867	5443867	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:5443867G>T	uc002kmt.1	-	5	585	c.499C>A	c.(499-501)CCT>ACT	p.P167T	EPB41L3_uc010wzh.1_Missense_Mutation_p.P167T|EPB41L3_uc002kmu.1_Missense_Mutation_p.P167T|EPB41L3_uc010dkq.1_Missense_Mutation_p.P58T|EPB41L3_uc010dks.1_Missense_Mutation_p.P189T|EPB41L3_uc002kmv.1_Missense_Mutation_p.P58T	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	167	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5																		---	---	---	---
TMEM200C	645369	broad.mit.edu	37	18	5891983	5891983	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:5891983C>T	uc002kmx.1	-	1	121	c.80G>A	c.(79-81)CGC>CAC	p.R27H		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	27						integral to membrane					0																		---	---	---	---
PTPRM	5797	broad.mit.edu	37	18	8370934	8370934	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:8370934A>G	uc002knn.3	+	22	3565	c.3062A>G	c.(3061-3063)GAC>GGC	p.D1021G	PTPRM_uc010dkv.2_Missense_Mutation_p.D1034G|PTPRM_uc010wzl.1_Missense_Mutation_p.D808G	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1021	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)																---	---	---	---
TXNDC2	84203	broad.mit.edu	37	18	9887504	9887504	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:9887504A>G	uc002koi.3	+	2	1477	c.1028A>G	c.(1027-1029)GAC>GGC	p.D343G	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.D276G	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	343	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.|16.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
TXNDC2	84203	broad.mit.edu	37	18	9887579	9887579	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:9887579A>T	uc002koi.3	+	2	1552	c.1103A>T	c.(1102-1104)CAG>CTG	p.Q368L	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.Q301L	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	368	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.|18.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
TUBB6	84617	broad.mit.edu	37	18	12308711	12308711	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12308711A>G	uc002kqw.2	+	2	128	c.83A>G	c.(82-84)CAC>CGC	p.H28R	TUBB6_uc002kqv.2_5'UTR|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Missense_Mutation_p.H28R|TUBB6_uc002kqy.2_Missense_Mutation_p.H28R	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	28					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)														---	---	---	---
SPIRE1	56907	broad.mit.edu	37	18	12454398	12454398	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12454398G>C	uc002kre.2	-	13	1770	c.1723C>G	c.(1723-1725)CTG>GTG	p.L575V	SPIRE1_uc002krc.2_RNA|SPIRE1_uc010wzw.1_Missense_Mutation_p.L441V|SPIRE1_uc010wzx.1_Missense_Mutation_p.L364V|SPIRE1_uc010wzy.1_Missense_Mutation_p.L561V	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a	575	Spir-box.					cytoskeleton|perinuclear region of cytoplasm	actin binding				0																		---	---	---	---
PTPN2	5771	broad.mit.edu	37	18	12830993	12830993	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12830993C>T	uc002krp.2	-	4	503	c.309G>A	c.(307-309)CAG>CAA	p.Q103Q	PTPN2_uc002krl.2_Silent_p.Q103Q|PTPN2_uc002krn.2_Silent_p.Q103Q|PTPN2_uc002kro.2_Silent_p.Q103Q|PTPN2_uc002krm.2_Silent_p.Q103Q	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	103	Tyrosine-protein phosphatase.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)																---	---	---	---
CHST9	83539	broad.mit.edu	37	18	24722722	24722722	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:24722722G>A	uc002kwd.2	-	1	250	c.52C>T	c.(52-54)CTG>TTG	p.L18L	C18orf16_uc010xbm.1_Intron|CHST9_uc002kwe.2_Silent_p.L18L	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	18	Helical; Signal-anchor for type II membrane protein; (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)																	---	---	---	---
MOCOS	55034	broad.mit.edu	37	18	33775270	33775270	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33775270C>T	uc002kzq.3	+	2	216	c.193C>T	c.(193-195)CTC>TTC	p.L65F		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	65					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)													---	---	---	---
CELF4	56853	broad.mit.edu	37	18	34854283	34854283	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:34854283G>A	uc002lae.2	-	6	1188	c.792C>T	c.(790-792)TAC>TAT	p.Y264Y	CELF4_uc010dnd.1_Silent_p.Y263Y|CELF4_uc002lag.2_Silent_p.Y254Y|CELF4_uc002laf.2_Silent_p.Y259Y|CELF4_uc002lai.2_Silent_p.Y249Y|CELF4_uc002lah.1_5'Flank|CELF4_uc002laj.1_Missense_Mutation_p.R100C	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	264	Sufficient for RNA-binding and MSE- dependent splicing activity.|Ala-rich.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2																		---	---	---	---
PIK3C3	5289	broad.mit.edu	37	18	39570520	39570520	+	Splice_Site	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:39570520T>C	uc002lap.2	+	6	772	c.714_splice	c.e6+2	p.K238_splice	PIK3C3_uc010xcl.1_Splice_Site_p.K175_splice	NM_002647	NP_002638			catalytic phosphatidylinositol 3-kinase 3						cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10															TSP Lung(28;0.18)			---	---	---	---
SETBP1	26040	broad.mit.edu	37	18	42531185	42531185	+	Missense_Mutation	SNP	G	A	A	rs138819848	byFrequency	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:42531185G>A	uc010dni.2	+	4	2176	c.1880G>A	c.(1879-1881)CGC>CAC	p.R627H		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	627						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)										Schinzel-Giedion_syndrome				---	---	---	---
SLC14A1	6563	broad.mit.edu	37	18	43328373	43328373	+	Missense_Mutation	SNP	G	A	A	rs147114544	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43328373G>A	uc010xcn.1	+	10	1298	c.979G>A	c.(979-981)GCA>ACA	p.A327T	SLC14A1_uc010dnk.2_Missense_Mutation_p.A383T|SLC14A1_uc002lbf.3_Missense_Mutation_p.A327T|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Missense_Mutation_p.A222T|SLC14A1_uc002lbh.3_Missense_Mutation_p.A219T|SLC14A1_uc002lbi.3_Missense_Mutation_p.A195T|SLC14A1_uc002lbj.3_Missense_Mutation_p.A383T|SLC14A1_uc002lbk.3_Missense_Mutation_p.A327T	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	327	Helical; (Potential).					integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
CDH20	28316	broad.mit.edu	37	18	59221564	59221564	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:59221564C>T	uc010dps.1	+	11	2054	c.2042C>T	c.(2041-2043)GCG>GTG	p.A681V	CDH20_uc002lif.2_Missense_Mutation_p.A675V	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	681	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)																---	---	---	---
PHLPP1	23239	broad.mit.edu	37	18	60609077	60609077	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:60609077G>A	uc002lis.2	+	12	1729	c.1551G>A	c.(1549-1551)GTG>GTA	p.V517V		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1029	LRR 16.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0																		---	---	---	---
SERPINB8	5271	broad.mit.edu	37	18	61654298	61654298	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:61654298C>T	uc002ljv.2	+	7	1080	c.911C>T	c.(910-912)ACT>ATT	p.T304I	SERPINB8_uc002lju.2_Missense_Mutation_p.T304I|SERPINB8_uc010xex.1_Missense_Mutation_p.T122I	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	304					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)																---	---	---	---
CD226	10666	broad.mit.edu	37	18	67563239	67563239	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:67563239G>A	uc010dqo.2	-	3	872	c.425C>T	c.(424-426)TCG>TTG	p.S142L	CD226_uc002lkm.3_Missense_Mutation_p.S142L	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	142	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)																---	---	---	---
C18orf55	29090	broad.mit.edu	37	18	71825638	71825638	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:71825638C>T	uc010dqr.1	+	6	968	c.670C>T	c.(670-672)CGA>TGA	p.R224*		NM_014177	NP_054896	Q9BVV7	TI21L_HUMAN	hypothetical protein LOC29090 precursor	224					protein transport|transmembrane transport	integral to membrane|mitochondrial membrane					0		Esophageal squamous(42;0.0746)|Prostate(75;0.157)|Melanoma(33;0.211)																---	---	---	---
ZNF236	7776	broad.mit.edu	37	18	74639309	74639309	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:74639309T>C	uc002lmi.2	+	24	4442	c.4244T>C	c.(4243-4245)CTG>CCG	p.L1415P	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1415					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)														---	---	---	---
SALL3	27164	broad.mit.edu	37	18	76757103	76757103	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:76757103C>T	uc002lmt.2	+	3	3684	c.3684C>T	c.(3682-3684)AAC>AAT	p.N1228N	SALL3_uc010dra.2_Silent_p.N763N	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1228					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)														---	---	---	---
NFATC1	4772	broad.mit.edu	37	18	77170868	77170868	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77170868C>T	uc010xfg.1	+	2	1046	c.593C>T	c.(592-594)GCG>GTG	p.A198V	NFATC1_uc002lnc.1_Missense_Mutation_p.A198V|NFATC1_uc010xff.1_Missense_Mutation_p.A198V|NFATC1_uc002lnd.2_Missense_Mutation_p.A198V|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Missense_Mutation_p.A198V|NFATC1_uc010xfi.1_Missense_Mutation_p.A185V|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Missense_Mutation_p.A185V|NFATC1_uc002lng.2_Missense_Mutation_p.A185V|NFATC1_uc010xfk.1_Missense_Mutation_p.A185V	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	198	Trans-activation domain A (TAD-A).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)														---	---	---	---
NFATC1	4772	broad.mit.edu	37	18	77287538	77287538	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77287538A>G	uc010xfg.1	+	10	3246	c.2793A>G	c.(2791-2793)ATA>ATG	p.I931M	NFATC1_uc002lnd.2_3'UTR|NFATC1_uc002lne.2_3'UTR|NFATC1_uc010xfh.1_Missense_Mutation_p.I701M|NFATC1_uc010xfj.1_Missense_Mutation_p.I459M|NFATC1_uc002lnf.2_Missense_Mutation_p.I918M|NFATC1_uc002lng.2_3'UTR|NFATC1_uc010xfk.1_Missense_Mutation_p.I688M|NFATC1_uc010drc.2_RNA	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	931	Nuclear export signal.|Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)														---	---	---	---
CTDP1	9150	broad.mit.edu	37	18	77475153	77475153	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77475153G>A	uc002lnh.1	+	8	1840	c.1693G>A	c.(1693-1695)GGG>AGG	p.G565R	CTDP1_uc002lni.1_Missense_Mutation_p.G565R|CTDP1_uc010drd.1_Missense_Mutation_p.G565R	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	565					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)														---	---	---	---
PPAP2C	8612	broad.mit.edu	37	19	287508	287508	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:287508A>G	uc002loi.2	-	3	547	c.448T>C	c.(448-450)TGC>CGC	p.C150R	PPAP2C_uc002loh.2_Missense_Mutation_p.C171R|PPAP2C_uc002loj.2_Missense_Mutation_p.C94R	NM_003712	NP_003703	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C isoform 1	150					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
PPAP2C	8612	broad.mit.edu	37	19	287537	287537	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:287537C>T	uc002loi.2	-	3	518	c.419G>A	c.(418-420)TGC>TAC	p.C140Y	PPAP2C_uc002loh.2_Missense_Mutation_p.C161Y|PPAP2C_uc002loj.2_Missense_Mutation_p.C84Y	NM_003712	NP_003703	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C isoform 1	140					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
FGF22	27006	broad.mit.edu	37	19	643535	643535	+	Silent	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:643535G>C	uc010xfq.1	+	3	444	c.444G>C	c.(442-444)GGG>GGC	p.G148G	FGF22_uc010xfr.1_Missense_Mutation_p.A141P	NM_020637	NP_065688	Q9HCT0	FGF22_HUMAN	fibroblast growth factor 22 precursor	148					cell differentiation|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular space	growth factor activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
FSTL3	10272	broad.mit.edu	37	19	681536	681536	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:681536G>A	uc002lpk.1	+	4	744	c.709G>A	c.(709-711)GTG>ATG	p.V237M	FSTL3_uc010drt.1_RNA	NM_005860	NP_005851	O95633	FSTL3_HUMAN	follistatin-like 3 glycoprotein precursor	237	Kazal-like 2.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)				T	CCND1	B-CLL								---	---	---	---
GRIN3B	116444	broad.mit.edu	37	19	1004645	1004645	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1004645C>T	uc002lqo.1	+	3	1145	c.1145C>T	c.(1144-1146)GCC>GTC	p.A382V		NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	382	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)													---	---	---	---
ABCA7	10347	broad.mit.edu	37	19	1054565	1054565	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1054565C>T	uc002lqw.3	+						ABCA7_uc010dsb.1_Intron|ABCA7_uc002lqy.2_5'Flank	NM_019112	NP_061985			ATP-binding cassette, sub-family A, member 7						phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
APC2	10297	broad.mit.edu	37	19	1468467	1468467	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1468467G>A	uc002lsr.1	+	15	5375	c.5167G>A	c.(5167-5169)GGG>AGG	p.G1723R	APC2_uc002lss.1_Missense_Mutation_p.G1305R|APC2_uc002lst.1_Missense_Mutation_p.G1723R|APC2_uc002lsu.1_Missense_Mutation_p.G1722R|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1723					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
TCF3	6929	broad.mit.edu	37	19	1619109	1619109	+	Splice_Site	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1619109C>T	uc002ltr.2	-	16	1517	c.1450_splice	c.e16+1	p.G484_splice	TCF3_uc002lto.2_Splice_Site_p.G245_splice|TCF3_uc002ltt.3_Splice_Site_p.G484_splice|TCF3_uc002ltq.2_Splice_Site_p.G433_splice|TCF3_uc002lts.1_Splice_Site_p.G400_splice	NM_003200	NP_003191			transcription factor 3 isoform E12						B cell lineage commitment|B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			lung(2)|breast(2)|ovary(1)|large_intestine(1)|skin(1)	7		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)				T	PBX1|HLF|TFPT	pre B-ALL								---	---	---	---
SLC39A3	29985	broad.mit.edu	37	19	2737213	2737213	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2737213C>T	uc002lwg.2	-	2	297	c.43G>A	c.(43-45)GTG>ATG	p.V15M	SLC39A3_uc010xgy.1_Missense_Mutation_p.V15M|SLC39A3_uc002lwh.2_Missense_Mutation_p.V15M	NM_144564	NP_653165	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter),	15	Helical; (Potential).					integral to membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ZNF556	80032	broad.mit.edu	37	19	2877353	2877353	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2877353A>G	uc002lwp.1	+	4	484	c.397A>G	c.(397-399)AAT>GAT	p.N133D	ZNF556_uc002lwq.2_Missense_Mutation_p.N132D	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
NFIC	4782	broad.mit.edu	37	19	3382066	3382066	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3382066G>A	uc010xhi.1	+	2	449	c.387G>A	c.(385-387)CGG>CGA	p.R129R	NFIC_uc002lxo.2_Silent_p.R120R|NFIC_uc010xhh.1_Silent_p.R120R|NFIC_uc002lxp.2_Silent_p.R129R|NFIC_uc010xhj.1_Silent_p.R129R|NFIC_uc002lxq.1_Silent_p.R81R	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	129	CTF/NF-I.				DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)														---	---	---	---
MRPL54	116541	broad.mit.edu	37	19	3767394	3767394	+	3'UTR	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3767394T>C	uc002lyq.3	+	3						NM_172251	NP_758455			mitochondrial ribosomal protein L54 precursor							mitochondrion|ribosome					0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ZFR2	23217	broad.mit.edu	37	19	3834969	3834969	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3834969C>T	uc002lyw.2	-	2	78	c.66G>A	c.(64-66)CCG>CCA	p.P22P	ZFR2_uc010xhx.1_RNA	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	22						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)														---	---	---	---
PIAS4	51588	broad.mit.edu	37	19	4024034	4024034	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4024034T>C	uc002lzg.2	+	3	465	c.455T>C	c.(454-456)GTC>GCC	p.V152A		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	152	PINIT.				positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
SH3GL1	6455	broad.mit.edu	37	19	4361746	4361746	+	Missense_Mutation	SNP	C	T	T	rs146842065		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4361746C>T	uc002maj.2	-	10	1064	c.958G>A	c.(958-960)GAG>AAG	p.E320K	SH3GL1_uc002mak.2_Missense_Mutation_p.E256K|SH3GL1_uc010xig.1_Missense_Mutation_p.E272K	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	320	SH3.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)				T	MLL	AL								---	---	---	---
SH3GL1	6455	broad.mit.edu	37	19	4361778	4361778	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4361778G>A	uc002maj.2	-	10	1032	c.926C>T	c.(925-927)CCG>CTG	p.P309L	SH3GL1_uc002mak.2_Missense_Mutation_p.P245L|SH3GL1_uc010xig.1_Missense_Mutation_p.P261L	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	309	SH3.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)				T	MLL	AL								---	---	---	---
CHAF1A	10036	broad.mit.edu	37	19	4428859	4428859	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4428859T>C	uc002mal.2	+	8	1676	c.1576T>C	c.(1576-1578)TCC>CCC	p.S526P		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	526					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding	p.S526F(1)		ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)									Chromatin_Structure					---	---	---	---
PLIN4	729359	broad.mit.edu	37	19	4511362	4511362	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4511362G>A	uc002mar.1	-	3	2568	c.2568C>T	c.(2566-2568)ACC>ACT	p.T856T	PLIN4_uc010dub.1_Intron	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	856	27 X 33 AA approximate tandem repeat.|24.					lipid particle|plasma membrane					0																		---	---	---	---
KDM4B	23030	broad.mit.edu	37	19	5047640	5047640	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5047640T>C	uc002mbq.3	+	6	812	c.586T>C	c.(586-588)TAC>CAC	p.Y196H	KDM4B_uc010xil.1_Missense_Mutation_p.Y196H|KDM4B_uc010xim.1_Missense_Mutation_p.Y196H	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	196	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1																		---	---	---	---
KDM4B	23030	broad.mit.edu	37	19	5111407	5111407	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5111407G>A	uc002mbq.3	+						KDM4B_uc010xil.1_Silent_p.P379P|KDM4B_uc010xim.1_Intron|KDM4B_uc002mbr.3_Intron	NM_015015	NP_055830			jumonji domain containing 2B						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1																		---	---	---	---
SAFB2	9667	broad.mit.edu	37	19	5587937	5587937	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5587937G>A	uc002mcd.2	-	19	2792	c.2580C>T	c.(2578-2580)CGC>CGT	p.R860R		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	860	Interacts with SAFB1.|Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)														---	---	---	---
DENND1C	79958	broad.mit.edu	37	19	6475354	6475354	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6475354C>T	uc002mfe.2	-	14	1076	c.984G>A	c.(982-984)GTG>GTA	p.V328V	DENND1C_uc002mfb.2_5'UTR|DENND1C_uc002mfc.2_5'UTR|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Silent_p.V284V	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	328	dDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1																		---	---	---	---
C3	718	broad.mit.edu	37	19	6678248	6678248	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6678248T>C	uc002mfm.2	-	40	4827	c.4765A>G	c.(4765-4767)AAG>GAG	p.K1589E	C3_uc002mfl.2_Missense_Mutation_p.K325E	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1589	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)														---	---	---	---
C3	718	broad.mit.edu	37	19	6690640	6690640	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6690640G>A	uc002mfm.2	-	27	3551	c.3489C>T	c.(3487-3489)AAC>AAT	p.N1163N	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1163				N->A: No effect on binding of C3d to CR2. Impaired binding of C3d to CR2; when associated with 1108-R-R-1109.|N->R: Impaired binding of C3d to CR2.	complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)														---	---	---	---
ARHGEF18	23370	broad.mit.edu	37	19	7523449	7523449	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7523449G>A	uc002mgi.2	+	9	1922	c.1669G>A	c.(1669-1671)GCC>ACC	p.A557T	ARHGEF18_uc010xjm.1_Missense_Mutation_p.A399T|ARHGEF18_uc002mgh.2_Missense_Mutation_p.A399T|ARHGEF18_uc002mgj.1_Missense_Mutation_p.A200T	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	557	PH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)																---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9049967	9049967	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9049967C>A	uc002mkp.2	-	5	31868	c.31664G>T	c.(31663-31665)AGG>ATG	p.R10555M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10557	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9083647	9083647	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9083647T>C	uc002mkp.2	-	1	8372	c.8168A>G	c.(8167-8169)CAT>CGT	p.H2723R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2723	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
ILF3	3609	broad.mit.edu	37	19	10790609	10790609	+	Intron	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10790609G>T	uc002mpn.2	+						ILF3_uc002mpm.2_Intron|ILF3_uc002mpl.2_Intron|ILF3_uc002mpk.2_Intron|ILF3_uc010xli.1_Intron|ILF3_uc002mpo.2_Intron|ILF3_uc002mpp.2_Intron	NM_012218	NP_036350			interleukin enhancer binding factor 3 isoform a						M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)															---	---	---	---
SMARCA4	6597	broad.mit.edu	37	19	11097631	11097631	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11097631G>A	uc002mqf.3	+	5	1095	c.811G>A	c.(811-813)GGG>AGG	p.G271R	SMARCA4_uc010dxp.2_Missense_Mutation_p.G271R|SMARCA4_uc010dxo.2_Missense_Mutation_p.G271R|SMARCA4_uc002mqg.1_Missense_Mutation_p.G271R|SMARCA4_uc010dxq.2_Missense_Mutation_p.G271R|SMARCA4_uc010dxr.2_Missense_Mutation_p.G271R|SMARCA4_uc002mqj.3_Missense_Mutation_p.G271R|SMARCA4_uc010dxs.2_Missense_Mutation_p.G271R|SMARCA4_uc002mqe.2_Missense_Mutation_p.G271R	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	271	Necessary for interaction with SS18L1/CREST (By similarity).				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)						F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				---	---	---	---
RGL3	57139	broad.mit.edu	37	19	11527510	11527510	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11527510C>T	uc002mrp.2	-	3	435	c.371G>A	c.(370-372)GGG>GAG	p.G124E	RGL3_uc002mrn.2_5'UTR|RGL3_uc002mrm.2_5'UTR|RGL3_uc002mro.2_Missense_Mutation_p.G124E|RGL3_uc002mrq.2_Missense_Mutation_p.G124E	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	124	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1																		---	---	---	---
PRKCSH	5589	broad.mit.edu	37	19	11552119	11552119	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11552119C>T	uc002mrt.2	+	6	751	c.415C>T	c.(415-417)CGT>TGT	p.R139C	PRKCSH_uc002mru.2_Missense_Mutation_p.R139C|PRKCSH_uc010xlz.1_Missense_Mutation_p.R139C|PRKCSH_uc010dya.2_Silent_p.S107S|PRKCSH_uc002mrv.1_Missense_Mutation_p.R139C|PRKCSH_uc010dyb.2_Missense_Mutation_p.R139C	NM_002743	NP_002734	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H isoform 1	139					innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding				0																		---	---	---	---
RAD23A	5886	broad.mit.edu	37	19	13063564	13063564	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13063564C>T	uc002mvw.1	+	8	984	c.875C>T	c.(874-876)GCG>GTG	p.A292V	RAD23A_uc002mvx.1_Missense_Mutation_p.A291V|RAD23A_uc002mvz.1_Missense_Mutation_p.A291V|RAD23A_uc002mwa.1_Intron|RAD23A_uc002mvy.1_Missense_Mutation_p.A126V|RAD23A_uc010xmw.1_Missense_Mutation_p.A127V	NM_005053	NP_005044	P54725	RD23A_HUMAN	UV excision repair protein RAD23 homolog A	292					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)	1													NER					---	---	---	---
OR7C1	26664	broad.mit.edu	37	19	14910551	14910551	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14910551G>A	uc010xnz.1	-	1	398	c.398C>T	c.(397-399)ACG>ATG	p.T133M		NM_198944	NP_945182	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C,	133	Cytoplasmic (Potential).				sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2																		---	---	---	---
CYP4F3	4051	broad.mit.edu	37	19	15752380	15752380	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15752380C>T	uc002nbj.2	+	2	205	c.155C>T	c.(154-156)CCG>CTG	p.P52L	CYP4F3_uc010xok.1_Missense_Mutation_p.P52L|CYP4F3_uc010xol.1_Missense_Mutation_p.P52L|CYP4F3_uc010xom.1_5'UTR|CYP4F3_uc002nbk.2_Missense_Mutation_p.P52L	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	52					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3																		---	---	---	---
OR10H2	26538	broad.mit.edu	37	19	15839703	15839703	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15839703C>T	uc002nbm.2	+	1	870	c.850C>T	c.(850-852)CCC>TCC	p.P284S		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)																	---	---	---	---
CYP4F2	8529	broad.mit.edu	37	19	16003188	16003188	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16003188C>T	uc002nbs.1	-	5	506	c.456G>A	c.(454-456)ACG>ACA	p.T152T	CYP4F2_uc010xot.1_Silent_p.T3T|CYP4F2_uc010xou.1_Silent_p.T3T	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	152					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2																		---	---	---	---
CHERP	10523	broad.mit.edu	37	19	16632356	16632356	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16632356G>A	uc002nei.1	-	12	2164	c.2090C>T	c.(2089-2091)CCG>CTG	p.P697L	MED26_uc002nee.2_Intron|CHERP_uc010xpg.1_Missense_Mutation_p.P236L	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	697					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2																		---	---	---	---
MED26	9441	broad.mit.edu	37	19	16689216	16689216	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16689216C>T	uc002nen.1	-	2	338	c.77G>A	c.(76-78)CGG>CAG	p.R26Q	MED26_uc002nee.2_RNA	NM_004831	NP_004822	O95402	MED26_HUMAN	mediator complex subunit 26	26	TFIIS N-terminal.				regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			ovary(2)	2																		---	---	---	---
NWD1	284434	broad.mit.edu	37	19	16874647	16874647	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16874647G>A	uc002neu.3	+	9	2564	c.2142G>A	c.(2140-2142)CCG>CCA	p.P714P	NWD1_uc002net.3_Silent_p.P579P|NWD1_uc002nev.3_Silent_p.P508P			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	714							ATP binding			skin(3)|ovary(2)|pancreas(2)	7																		---	---	---	---
PLVAP	83483	broad.mit.edu	37	19	17476311	17476311	+	Silent	SNP	C	T	T	rs150210307		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17476311C>T	uc002ngk.1	-	3	1013	c.963G>A	c.(961-963)GCG>GCA	p.A321A		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	321	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0																		---	---	---	---
KIAA1683	80726	broad.mit.edu	37	19	18368203	18368203	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18368203C>T	uc002nin.2	-	4	3546	c.3330G>A	c.(3328-3330)CCG>CCA	p.P1110P	PDE4C_uc002nil.3_5'Flank|KIAA1683_uc010ebn.2_Silent_p.P1297P|KIAA1683_uc010xqe.1_Silent_p.P1064P|KIAA1683_uc010xqf.1_RNA	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	1110						mitochondrion				ovary(2)	2																		---	---	---	---
KIAA1683	80726	broad.mit.edu	37	19	18368702	18368702	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18368702C>T	uc002nin.2	-	4	3047	c.2831G>A	c.(2830-2832)CGC>CAC	p.R944H	PDE4C_uc002nil.3_5'Flank|KIAA1683_uc010ebn.2_Missense_Mutation_p.R1131H|KIAA1683_uc010xqe.1_Missense_Mutation_p.R898H|KIAA1683_uc010xqf.1_RNA	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	944	IQ 2.					mitochondrion				ovary(2)	2																		---	---	---	---
ISYNA1	51477	broad.mit.edu	37	19	18547133	18547133	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18547133C>T	uc002njd.1	-						ISYNA1_uc002nja.1_Intron|ISYNA1_uc002njb.1_Intron|ISYNA1_uc002njc.1_Intron|ISYNA1_uc010xqh.1_Intron|ISYNA1_uc002nje.1_Intron|ISYNA1_uc002njf.1_Intron	NM_016368	NP_057452			inositol-3-phosphate synthase 1						inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
ZNF101	94039	broad.mit.edu	37	19	19790992	19790992	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19790992G>C	uc002nni.1	+	4	1304	c.1194G>C	c.(1192-1194)CAG>CAC	p.Q398H	ZNF101_uc010ecg.1_Missense_Mutation_p.Q278H|ZNF101_uc002nnj.1_Missense_Mutation_p.Q278H	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	398	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2																		---	---	---	---
ZNF676	163223	broad.mit.edu	37	19	22363169	22363169	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22363169T>C	uc002nqs.1	-	3	1668	c.1350A>G	c.(1348-1350)AAA>AAG	p.K450K		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	450	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)																---	---	---	---
ZNF676	163223	broad.mit.edu	37	19	22363511	22363511	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22363511G>A	uc002nqs.1	-	3	1326	c.1008C>T	c.(1006-1008)CCC>CCT	p.P336P		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	336					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)																---	---	---	---
ZNF676	163223	broad.mit.edu	37	19	22375886	22375886	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22375886A>T	uc002nqs.1	-	2	380	c.62T>A	c.(61-63)ATC>AAC	p.I21N		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	21	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)																---	---	---	---
ZNF91	7644	broad.mit.edu	37	19	23543818	23543818	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:23543818C>G	uc002nre.2	-	4	2076	c.1963G>C	c.(1963-1965)GAG>CAG	p.E655Q	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.E623Q	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	655						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)																---	---	---	---
ZNF681	148213	broad.mit.edu	37	19	23927062	23927062	+	Silent	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:23927062A>C	uc002nrk.3	-	4	1432	c.1290T>G	c.(1288-1290)GCT>GCG	p.A430A	ZNF681_uc002nrl.3_Silent_p.A361A|ZNF681_uc002nrj.3_Silent_p.A361A	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	430	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)																---	---	---	---
CCNE1	898	broad.mit.edu	37	19	30313408	30313408	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:30313408G>T	uc002nsn.2	+	11	1191	c.1008G>T	c.(1006-1008)ATG>ATT	p.M336I	CCNE1_uc002nso.2_Missense_Mutation_p.M321I|CCNE1_uc002nsp.2_Missense_Mutation_p.M83I	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	336					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)															---	---	---	---
RHPN2	85415	broad.mit.edu	37	19	33487079	33487079	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33487079G>A	uc002nuf.2	-	11	1339	c.1273C>T	c.(1273-1275)CGG>TGG	p.R425W	RHPN2_uc010xro.1_Missense_Mutation_p.R274W|RHPN2_uc002nue.2_Missense_Mutation_p.R155W	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	425	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)																	---	---	---	---
MAG	4099	broad.mit.edu	37	19	35791095	35791095	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35791095A>T	uc002nyy.1	+	6	907	c.758A>T	c.(757-759)GAG>GTG	p.E253V	MAG_uc002nyx.1_Missense_Mutation_p.E253V|MAG_uc010eds.1_Missense_Mutation_p.E228V|MAG_uc002nyz.1_Missense_Mutation_p.E253V	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	253	Ig-like C2-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)															---	---	---	---
COX6B1	1340	broad.mit.edu	37	19	36149530	36149530	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36149530C>T	uc002oav.2	+	4	404	c.242C>T	c.(241-243)ACG>ATG	p.T81M		NM_001863	NP_001854	P14854	CX6B1_HUMAN	cytochrome c oxidase subunit VIb polypeptide 1	81					respiratory electron transport chain	mitochondrial inner membrane|mitochondrial intermembrane space	cytochrome-c oxidase activity				0	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
ARHGAP33	115703	broad.mit.edu	37	19	36276343	36276343	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36276343G>A	uc002obr.1	+	19	1985	c.1900G>A	c.(1900-1902)GCC>ACC	p.A634T	ARHGAP33_uc002obs.1_Missense_Mutation_p.A634T|ARHGAP33_uc002obt.1_Missense_Mutation_p.A498T|ARHGAP33_uc010eel.2_Missense_Mutation_p.A222T|ARHGAP33_uc002obv.1_Missense_Mutation_p.A222T	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	634					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
ARHGAP33	115703	broad.mit.edu	37	19	36277956	36277956	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36277956G>T	uc002obr.1	+	20	2669	c.2584G>T	c.(2584-2586)GGA>TGA	p.G862*	ARHGAP33_uc002obs.1_Nonsense_Mutation_p.G701*|ARHGAP33_uc002obt.1_Nonsense_Mutation_p.G726*|ARHGAP33_uc010eel.2_Nonsense_Mutation_p.G450*|ARHGAP33_uc002obv.1_Nonsense_Mutation_p.G450*	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	862					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
PRODH2	58510	broad.mit.edu	37	19	36293120	36293120	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36293120T>C	uc002obx.1	-	10	1417	c.1399A>G	c.(1399-1401)ATG>GTG	p.M467V		NM_021232	NP_067055	Q9UF12	PROD2_HUMAN	kidney and liver proline oxidase 1	467					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			ovary(2)	2	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
APLP1	333	broad.mit.edu	37	19	36369799	36369799	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36369799C>T	uc002oce.2	+	15	1793	c.1655C>T	c.(1654-1656)GCG>GTG	p.A552V	APLP1_uc010xsz.1_Missense_Mutation_p.A513V|APLP1_uc002ocf.2_Missense_Mutation_p.A553V|APLP1_uc002ocg.2_Missense_Mutation_p.A456V|APLP1_uc010xta.1_Missense_Mutation_p.A546V	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	552	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
WDR62	284403	broad.mit.edu	37	19	36580076	36580076	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36580076G>A	uc002odc.2	+						WDR62_uc002odd.2_Intron	NM_173636	NP_775907			WD repeat domain 62 isoform 2						cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)															---	---	---	---
ZNF527	84503	broad.mit.edu	37	19	37871245	37871245	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37871245A>C	uc010efk.1	+	4	338	c.227A>C	c.(226-228)GAG>GCG	p.E76A	ZNF527_uc002ogf.3_Intron|ZNF527_uc010xtq.1_RNA|ZNF527_uc002oge.2_Missense_Mutation_p.E76A	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	76	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
GGN	199720	broad.mit.edu	37	19	38876360	38876360	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38876360G>A	uc002oij.1	-	3	1677	c.1542C>T	c.(1540-1542)CCC>CCT	p.P514P	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Silent_p.P431P	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	514	Interactions with ZNF403/GGNBP2 and OAZ3 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)															---	---	---	---
SUPT5H	6829	broad.mit.edu	37	19	39964163	39964163	+	Splice_Site	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39964163T>C	uc002olo.3	+	25	2671	c.2492_splice	c.e25+2	p.R831_splice	SUPT5H_uc002olp.3_Splice_Site_p.R831_splice|SUPT5H_uc002olq.3_Splice_Site_p.R827_splice|SUPT5H_uc002oln.3_Splice_Site_p.R831_splice|SUPT5H_uc002olr.3_Splice_Site_p.R831_splice|SUPT5H_uc002ols.1_Splice_Site_p.R454_splice	NM_001111020	NP_001104490			suppressor of Ty 5 homolog isoform a						cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)															---	---	---	---
C19orf47	126526	broad.mit.edu	37	19	40832280	40832280	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40832280G>A	uc002oni.3	-	7	665	c.664C>T	c.(664-666)CGC>TGC	p.R222C	C19orf47_uc002ong.2_Missense_Mutation_p.R81C|C19orf47_uc002onh.2_Missense_Mutation_p.R155C	NM_178830	NP_849152	Q8N9M1	CS047_HUMAN	hypothetical protein LOC126526	222										ovary(1)|skin(1)	2			Lung(22;0.000636)															---	---	---	---
SPTBN4	57731	broad.mit.edu	37	19	40993644	40993644	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40993644G>T	uc002ony.2	+	3	296	c.210G>T	c.(208-210)TGG>TGT	p.W70C	SPTBN4_uc002onx.2_Missense_Mutation_p.W70C|SPTBN4_uc002onz.2_Missense_Mutation_p.W70C	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	70	CH 1.|Actin-binding.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
SHKBP1	92799	broad.mit.edu	37	19	41086826	41086826	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41086826C>T	uc002oob.2	+	9	877	c.828C>T	c.(826-828)GGC>GGT	p.G276G	SHKBP1_uc002ooc.2_Silent_p.G276G|SHKBP1_uc002ood.2_Silent_p.G276G|SHKBP1_uc010xvl.1_Silent_p.G199G|SHKBP1_uc002ooe.2_Silent_p.G113G|SHKBP1_uc002oof.2_Silent_p.G113G|SHKBP1_uc010xvm.1_Silent_p.G113G|SHKBP1_uc010xvn.1_Silent_p.G154G	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	276	WD 1.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
CEACAM4	1089	broad.mit.edu	37	19	42128059	42128059	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42128059G>T	uc002orh.1	-	3	618	c.507C>A	c.(505-507)GCC>GCA	p.A169A	CEACAM4_uc010xwd.1_Silent_p.A169A	NM_001817	NP_001808	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion	169	Helical; (Potential).					integral to plasma membrane|membrane fraction					0																		---	---	---	---
RABAC1	10567	broad.mit.edu	37	19	42462889	42462889	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42462889C>T	uc002osf.2	-	2	352	c.268G>A	c.(268-270)GTG>ATG	p.V90M		NM_006423	NP_006414	Q9UI14	PRAF1_HUMAN	Rab acceptor 1	90	Helical; (By similarity).					cell junction|Golgi apparatus|integral to membrane|synaptic vesicle	identical protein binding				0																		---	---	---	---
GRIK5	2901	broad.mit.edu	37	19	42510901	42510901	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42510901C>T	uc002osj.1	-	15	1968	c.1933G>A	c.(1933-1935)GTG>ATG	p.V645M	GRIK5_uc002osi.1_Missense_Mutation_p.V217M	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	645	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)													---	---	---	---
ERF	2077	broad.mit.edu	37	19	42752808	42752808	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42752808G>A	uc002ote.3	-	4	1614	c.1456C>T	c.(1456-1458)CGG>TGG	p.R486W	ERF_uc002otd.3_Missense_Mutation_p.R217W	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	486					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)																---	---	---	---
ERF	2077	broad.mit.edu	37	19	42752834	42752834	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42752834C>T	uc002ote.3	-	4	1588	c.1430G>A	c.(1429-1431)TGC>TAC	p.C477Y	ERF_uc002otd.3_Missense_Mutation_p.C208Y	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	477					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)																---	---	---	---
MEGF8	1954	broad.mit.edu	37	19	42848707	42848707	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42848707G>A	uc002otl.3	+	11	2538	c.1903G>A	c.(1903-1905)GTG>ATG	p.V635M	MEGF8_uc002otm.3_Missense_Mutation_p.V176M	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	675	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)																---	---	---	---
LIPE	3991	broad.mit.edu	37	19	42914843	42914843	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42914843C>T	uc002otr.2	-	2	1312	c.1035G>A	c.(1033-1035)GCG>GCA	p.A345A	uc010eif.1_Intron|LIPE_uc002ots.1_Silent_p.A90A	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	345					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)																---	---	---	---
PSG1	5669	broad.mit.edu	37	19	43372462	43372462	+	Missense_Mutation	SNP	C	T	T	rs1058748		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43372462C>T	uc002ovb.2	-	5	1172	c.1034G>A	c.(1033-1035)CGT>CAT	p.R345H	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_Intron|PSG1_uc002our.1_Missense_Mutation_p.R345H|PSG1_uc010eio.1_Missense_Mutation_p.R345H|PSG1_uc002oux.1_Missense_Mutation_p.R274H|PSG1_uc002ouy.1_Missense_Mutation_p.R252H|PSG1_uc002ouz.1_Missense_Mutation_p.R345H|PSG1_uc002ova.1_Missense_Mutation_p.R252H|PSG1_uc002ovc.2_Missense_Mutation_p.R252H|PSG1_uc002ovd.1_Missense_Mutation_p.R345H	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	345	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)																---	---	---	---
IRGC	56269	broad.mit.edu	37	19	44223764	44223764	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44223764G>A	uc002oxh.2	+	2	1201	c.1054G>A	c.(1054-1056)GAC>AAC	p.D352N		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	352						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)																---	---	---	---
PVR	5817	broad.mit.edu	37	19	45162145	45162145	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45162145G>T	uc002ozm.2	+	6	1426	c.1127G>T	c.(1126-1128)TGG>TTG	p.W376L	PVR_uc010ejs.2_Missense_Mutation_p.W376L|PVR_uc010xxb.1_Intron|PVR_uc010xxc.1_Intron|PVR_uc002ozn.2_Missense_Mutation_p.W321L	NM_006505	NP_006496	P15151	PVR_HUMAN	poliovirus receptor isoform alpha	376	Cytoplasmic (Potential).				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity				0	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)														---	---	---	---
BCAM	4059	broad.mit.edu	37	19	45322873	45322873	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45322873C>T	uc002ozu.2	+	13	1697	c.1653C>T	c.(1651-1653)GTC>GTT	p.V551V	BCAM_uc002ozt.1_Silent_p.V551V	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	551	Helical; (Potential).				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)																---	---	---	---
ERCC2	2068	broad.mit.edu	37	19	45856040	45856040	+	Silent	SNP	G	A	A	rs16979773	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45856040G>A	uc002pbj.2	-	20	1913	c.1866C>T	c.(1864-1866)GGC>GGT	p.G622G	ERCC2_uc002pbh.2_Silent_p.G185G|ERCC2_uc002pbi.2_Silent_p.G315G|ERCC2_uc010ejz.2_Silent_p.G544G|ERCC2_uc002pbk.2_Silent_p.G598G	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	622	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)				Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				---	---	---	---
PPP1R13L	10848	broad.mit.edu	37	19	45899896	45899896	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45899896G>T	uc002pbn.2	-	4	696	c.619C>A	c.(619-621)CCT>ACT	p.P207T	PPP1R13L_uc002pbo.2_Missense_Mutation_p.P207T|PPP1R13L_uc002pbp.2_Missense_Mutation_p.P207T	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	207	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)														---	---	---	---
ELSPBP1	64100	broad.mit.edu	37	19	48511920	48511920	+	5'UTR	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48511920C>T	uc002pht.2	+	2						NM_022142	NP_071425			epididymal sperm binding protein 1 precursor						single fertilization	extracellular region					0		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)														---	---	---	---
LIG1	3978	broad.mit.edu	37	19	48634326	48634326	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48634326C>T	uc002pia.1	-						LIG1_uc010xze.1_Intron|LIG1_uc002phz.1_Intron|LIG1_uc002pib.1_Intron|LIG1_uc010xzf.1_Intron|LIG1_uc010xzg.1_Intron	NM_000234	NP_000225			DNA ligase I						anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)								NER					---	---	---	---
ZNF114	163071	broad.mit.edu	37	19	48789060	48789060	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48789060C>T	uc002pil.1	+	6	676	c.179C>T	c.(178-180)CCG>CTG	p.P60L	ZNF114_uc010elv.1_Missense_Mutation_p.P60L|ZNF114_uc002pim.1_Missense_Mutation_p.P60L|ZNF114_uc002pin.2_Missense_Mutation_p.P26L	NM_153608	NP_705836	Q8NC26	ZN114_HUMAN	zinc finger protein 114	60	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)														---	---	---	---
IZUMO1	284359	broad.mit.edu	37	19	49245072	49245072	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49245072G>A	uc002pkj.2	-	8	1276	c.728C>T	c.(727-729)GCC>GTC	p.A243V	RASIP1_uc002pki.2_5'Flank|IZUMO1_uc010eme.2_RNA|IZUMO1_uc010emf.2_RNA	NM_182575	NP_872381	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1 precursor	243	Ig-like C2-type.|Extracellular (Potential).				fusion of sperm to egg plasma membrane	integral to membrane		p.A243A(1)		ovary(1)	1		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)														---	---	---	---
SNRNP70	6625	broad.mit.edu	37	19	49601926	49601926	+	Missense_Mutation	SNP	C	T	T	rs11539820		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49601926C>T	uc002pmk.2	+	6	797	c.358C>T	c.(358-360)CGG>TGG	p.R120W	SNRNP70_uc002pmh.1_RNA|SNRNP70_uc002pmi.1_Missense_Mutation_p.R120W|SNRNP70_uc002pml.2_5'UTR|SNRNP70_uc002pmm.2_RNA	NM_003089	NP_003080	P08621	RU17_HUMAN	U1 small nuclear ribonucleoprotein 70 kDa	120	RRM.				nuclear mRNA splicing, via spliceosome|regulation of RNA splicing	nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0																OREG0025616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RPL13A	23521	broad.mit.edu	37	19	49994179	49994179	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49994179G>A	uc002pny.2	+						RPL13A_uc002pnz.2_Intron|RPL13A_uc002poa.2_Intron|SNORD34_uc010ena.1_RNA|SNORD35A_uc010enb.1_5'Flank	NM_012423	NP_036555			ribosomal protein L13a						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)														---	---	---	---
IL4I1	259307	broad.mit.edu	37	19	50399296	50399296	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50399296C>T	uc002pqt.1	-	3	106	c.28G>A	c.(28-30)GTC>ATC	p.V10I	IL4I1_uc002pqv.1_Missense_Mutation_p.V19I|IL4I1_uc010eno.1_Missense_Mutation_p.V18I|IL4I1_uc002pqw.1_Missense_Mutation_p.V18I|IL4I1_uc002pqu.1_Missense_Mutation_p.V32I	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	10						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)														---	---	---	---
NUP62	23636	broad.mit.edu	37	19	50412020	50412020	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50412020G>A	uc002pqx.2	-	2	1149	c.1045C>T	c.(1045-1047)CGG>TGG	p.R349W	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.R349W|NUP62_uc002pqz.2_Missense_Mutation_p.R349W|NUP62_uc002pra.2_Missense_Mutation_p.R349W|NUP62_uc002prb.2_Missense_Mutation_p.R349W|NUP62_uc002prc.2_Intron	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	349	Potential.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)														---	---	---	---
MYH14	79784	broad.mit.edu	37	19	50735186	50735186	+	Splice_Site	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50735186G>A	uc002prr.1	+	9	997	c.950_splice	c.e9-1	p.A317_splice	MYH14_uc010enu.1_Splice_Site_p.A325_splice|MYH14_uc002prq.1_Splice_Site_p.A325_splice	NM_024729	NP_079005			myosin, heavy chain 14 isoform 2						axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)														---	---	---	---
MYBPC2	4606	broad.mit.edu	37	19	50951604	50951604	+	Missense_Mutation	SNP	G	A	A	rs144074433	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50951604G>A	uc002psf.2	+	13	1480	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	477	Ig-like C2-type 4.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)														---	---	---	---
LRRC4B	94030	broad.mit.edu	37	19	51021132	51021132	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51021132C>T	uc002pss.2	-	3	1975	c.1838G>A	c.(1837-1839)CGC>CAC	p.R613H		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	613	Cytoplasmic (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)														---	---	---	---
KLK13	26085	broad.mit.edu	37	19	51561877	51561877	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51561877T>C	uc002pvn.2	-	4	606	c.563A>G	c.(562-564)GAG>GGG	p.E188G	KLK13_uc002pvl.2_RNA|KLK13_uc002pvm.2_RNA|KLK13_uc002pvo.2_RNA|KLK13_uc002pvp.2_RNA|KLK13_uc010eon.2_Missense_Mutation_p.E115G|KLK13_uc002pvq.2_RNA|KLK13_uc010eoo.2_Missense_Mutation_p.E36G	NM_015596	NP_056411	Q9UKR3	KLK13_HUMAN	kallikrein 13 precursor	188	Peptidase S1.				proteolysis		protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)														---	---	---	---
FPR2	2358	broad.mit.edu	37	19	52272775	52272775	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52272775C>T	uc002pxr.2	+	2	909	c.864C>T	c.(862-864)AGC>AGT	p.S288S	FPR2_uc002pxs.3_Silent_p.S288S|FPR2_uc010epf.2_Silent_p.S288S	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	288	Helical; Name=7; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4																		---	---	---	---
ZNF616	90317	broad.mit.edu	37	19	52619216	52619216	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52619216G>A	uc002pym.2	-	4	1484	c.1201C>T	c.(1201-1203)CGA>TGA	p.R401*	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	401	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)														---	---	---	---
ZNF808	388558	broad.mit.edu	37	19	53050886	53050886	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53050886C>T	uc010epq.1	+	4	362	c.185C>T	c.(184-186)GCT>GTT	p.A62V	ZNF808_uc002pzq.2_Intron	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	62	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)														---	---	---	---
ZNF600	162966	broad.mit.edu	37	19	53269926	53269926	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53269926A>G	uc002qab.3	-	3	1369	c.1083T>C	c.(1081-1083)AAT>AAC	p.N361N		NM_198457	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	361	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)														---	---	---	---
ZNF320	162967	broad.mit.edu	37	19	53385079	53385079	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53385079C>T	uc002qag.2	-	4	491	c.300G>A	c.(298-300)CAG>CAA	p.Q100Q	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Silent_p.Q46Q|ZNF320_uc002qai.2_Silent_p.Q100Q	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)														---	---	---	---
ZNF765	91661	broad.mit.edu	37	19	53911017	53911017	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53911017A>G	uc010ydx.1	+	6	536	c.209A>G	c.(208-210)CAT>CGT	p.H70R	ZNF765_uc002qbm.2_Missense_Mutation_p.H70R|ZNF765_uc002qbn.2_Intron	NM_001040185	NP_001035275	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	70	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00379)														---	---	---	---
LILRA6	79168	broad.mit.edu	37	19	54744212	54744212	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54744212G>T	uc002qeu.1	-	6	1320	c.1196C>A	c.(1195-1197)TCA>TAA	p.S399*	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Nonsense_Mutation_p.S399*|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Nonsense_Mutation_p.S399*|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Nonsense_Mutation_p.S399*|LILRA6_uc010yeq.1_Nonsense_Mutation_p.S399*|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Nonsense_Mutation_p.S260*	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	399	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)														---	---	---	---
SBK2	646643	broad.mit.edu	37	19	56042650	56042650	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56042650C>T	uc010ygc.1	-	2	316	c.316G>A	c.(316-318)GAG>AAG	p.E106K		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	106	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0																		---	---	---	---
ZNF71	58491	broad.mit.edu	37	19	57133126	57133126	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57133126G>A	uc002qnm.3	+	3	709	c.471G>A	c.(469-471)CCG>CCA	p.P157P		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	157						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)														---	---	---	---
ZNF304	57343	broad.mit.edu	37	19	57866632	57866632	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57866632G>A	uc010ygw.1	+						ZNF304_uc010etw.2_Intron|ZNF304_uc010etx.2_Intron	NM_020657	NP_065708			zinc finger protein 304						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)														---	---	---	---
ZSCAN4	201516	broad.mit.edu	37	19	58189820	58189820	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58189820T>C	uc002qpu.2	+	5	1546	c.849T>C	c.(847-849)CCT>CCC	p.P283P		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	283					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
ZNF497	162968	broad.mit.edu	37	19	58867595	58867595	+	Silent	SNP	G	A	A	rs143724070		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58867595G>A	uc002qsh.1	-	3	1596	c.1407C>T	c.(1405-1407)CCC>CCT	p.P469P	A1BG_uc002qsd.3_5'Flank|A1BG_uc002qsf.1_Intron|ZNF497_uc002qsi.1_Silent_p.P469P|uc002qsj.1_5'Flank|uc002qsk.1_5'Flank	NM_198458	NP_940860	Q6ZNH5	ZN497_HUMAN	zinc finger protein 497	469					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0278)														---	---	---	---
RPS5	6193	broad.mit.edu	37	19	58904820	58904820	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58904820C>T	uc002qsn.2	+	4	485	c.413C>T	c.(412-414)GCT>GTT	p.A138V	RPS5_uc002qso.2_Missense_Mutation_p.A138V	NM_001009	NP_001000	P46782	RS5_HUMAN	ribosomal protein S5	138					endocrine pancreas development|regulation of translational fidelity|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|structural constituent of ribosome				0		all_cancers(17;1.71e-22)|all_epithelial(17;1.69e-16)|Lung NSC(17;2.25e-06)|all_lung(17;9.97e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Breast(46;0.0194)|Ovarian(87;0.0443)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.171)|GBM - Glioblastoma multiforme(193;0.0323)|Lung(386;0.0543)|LUSC - Lung squamous cell carcinoma(496;0.176)														---	---	---	---
ZNF324	25799	broad.mit.edu	37	19	58980635	58980635	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58980635G>A	uc002qsw.1	+	2	177	c.83G>A	c.(82-84)CGC>CAC	p.R28H	ZNF324_uc002qsx.1_5'Flank	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)														---	---	---	---
MZF1	7593	broad.mit.edu	37	19	59082545	59082545	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:59082545T>C	uc002qto.2	-	2	773	c.212A>G	c.(211-213)CAG>CGG	p.Q71R	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Missense_Mutation_p.Q71R|MZF1_uc010euu.1_Missense_Mutation_p.Q112R	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	71	SCAN box.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)														---	---	---	---
DEFB126	81623	broad.mit.edu	37	20	126315	126315	+	Silent	SNP	C	T	T	rs11467417		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:126315C>T	uc002wcx.2	+	2	336	c.318C>T	c.(316-318)CCC>CCT	p.P106P		NM_030931	NP_112193	Q9BYW3	DB126_HUMAN	defensin, beta 126 preproprotein	106					defense response to bacterium	extracellular region					0		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)															---	---	---	---
SIGLEC1	6614	broad.mit.edu	37	20	3669851	3669851	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3669851C>T	uc002wja.2	-	20	5021	c.5021G>A	c.(5020-5022)AGC>AAC	p.S1674N	SIGLEC1_uc002wjb.1_3'UTR|SIGLEC1_uc002wiz.3_Intron	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1674	Cytoplasmic (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10																		---	---	---	---
MAVS	57506	broad.mit.edu	37	20	3846576	3846576	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3846576C>A	uc002wjw.3	+	7	1574	c.1405C>A	c.(1405-1407)CAC>AAC	p.H469N	MAVS_uc002wjx.3_Missense_Mutation_p.H328N|MAVS_uc002wjy.3_Missense_Mutation_p.H167N	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	469	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0																		---	---	---	---
LRRN4	164312	broad.mit.edu	37	20	6021879	6021879	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:6021879C>T	uc002wmo.2	-	5	2236	c.2012G>A	c.(2011-2013)TGC>TAC	p.C671Y		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	671	Extracellular (Potential).					integral to membrane				skin(3)	3																		---	---	---	---
JAG1	182	broad.mit.edu	37	20	10625879	10625879	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:10625879C>T	uc002wnw.2	-	17	2655	c.2139G>A	c.(2137-2139)ACG>ACA	p.T713T	JAG1_uc010gcd.1_Silent_p.T271T	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	713	Extracellular (Potential).|EGF-like 13.				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9														Alagille_Syndrome				---	---	---	---
JAG1	182	broad.mit.edu	37	20	10628735	10628735	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:10628735A>G	uc002wnw.2	-	13	2109	c.1593T>C	c.(1591-1593)CCT>CCC	p.P531P	JAG1_uc010gcd.1_Silent_p.P89P	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	531	Extracellular (Potential).|EGF-like 9.				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9														Alagille_Syndrome				---	---	---	---
JAG1	182	broad.mit.edu	37	20	10637041	10637041	+	Intron	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:10637041T>A	uc002wnw.2	-							NM_000214	NP_000205			jagged 1 precursor						angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9														Alagille_Syndrome				---	---	---	---
SPTLC3	55304	broad.mit.edu	37	20	13098152	13098152	+	Splice_Site	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13098152G>A	uc002wod.1	+	8	1222	c.933_splice	c.e8-1	p.S311_splice		NM_018327	NP_060797			serine palmitoyltransferase, long chain base						sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)													---	---	---	---
XRN2	22803	broad.mit.edu	37	20	21329003	21329003	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21329003G>A	uc002wsf.1	+	19	1893	c.1798G>A	c.(1798-1800)GGG>AGG	p.G600R	XRN2_uc002wsg.1_Missense_Mutation_p.G524R|XRN2_uc010zsk.1_Missense_Mutation_p.G546R	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	600					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1																		---	---	---	---
XRN2	22803	broad.mit.edu	37	20	21346276	21346276	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21346276C>G	uc002wsf.1	+	26	2485	c.2390C>G	c.(2389-2391)CCT>CGT	p.P797R	XRN2_uc002wsg.1_Missense_Mutation_p.P721R|XRN2_uc010zsk.1_Missense_Mutation_p.P743R	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	797					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1																		---	---	---	---
NAPB	63908	broad.mit.edu	37	20	23377795	23377795	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23377795T>C	uc002wta.2	-	3	326	c.209A>G	c.(208-210)AAG>AGG	p.K70R	NAPB_uc002wtc.2_5'UTR|NAPB_uc002wtb.2_Missense_Mutation_p.K74R|NAPB_uc002wtd.3_RNA|NAPB_uc010zss.1_5'Flank|NAPB_uc010zst.1_Intron	NM_022080	NP_071363	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment	70					intracellular protein transport|vesicle-mediated transport	membrane				ovary(1)	1	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)																	---	---	---	---
CST9L	128821	broad.mit.edu	37	20	23545639	23545639	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23545639G>T	uc002wtk.3	-	3	689	c.390C>A	c.(388-390)CCC>CCA	p.P130P		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	130						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)																	---	---	---	---
KIF3B	9371	broad.mit.edu	37	20	30897800	30897800	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30897800G>A	uc002wxq.2	+	2	387	c.220G>A	c.(220-222)GAT>AAT	p.D74N	KIF3B_uc010ztv.1_Missense_Mutation_p.D74N|KIF3B_uc010ztw.1_Missense_Mutation_p.D74N	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	74	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)															---	---	---	---
KIF3B	9371	broad.mit.edu	37	20	30898711	30898711	+	Missense_Mutation	SNP	G	T	T	rs1923098		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30898711G>T	uc002wxq.2	+	2	1298	c.1131G>T	c.(1129-1131)AGG>AGT	p.R377S	KIF3B_uc010ztv.1_Intron|KIF3B_uc010ztw.1_Intron	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	377	Potential.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)															---	---	---	---
C20orf114	92747	broad.mit.edu	37	20	31893802	31893802	+	Intron	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31893802T>A	uc002wyw.1	+						C20orf114_uc002wyx.1_Intron	NM_033197	NP_149974			LPLUNC1 protein precursor							extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4																		---	---	---	---
NCOA6	23054	broad.mit.edu	37	20	33337956	33337956	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33337956T>C	uc002xav.2	-	10	4613	c.2042A>G	c.(2041-2043)AAG>AGG	p.K681R	NCOA6_uc002xaw.2_Missense_Mutation_p.K681R	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	681	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7																		---	---	---	---
NCOA6	23054	broad.mit.edu	37	20	33345770	33345770	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33345770G>A	uc002xav.2	-	8	3352	c.781C>T	c.(781-783)CAG>TAG	p.Q261*	NCOA6_uc002xaw.2_Nonsense_Mutation_p.Q261*|NCOA6_uc010gew.1_Nonsense_Mutation_p.Q218*	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	261	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7																		---	---	---	---
MYH7B	57644	broad.mit.edu	37	20	33584501	33584501	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33584501C>T	uc002xbi.1	+	28	3424	c.3332C>T	c.(3331-3333)ACG>ATG	p.T1111M		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1069	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)															---	---	---	---
RBL1	5933	broad.mit.edu	37	20	35689589	35689589	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35689589T>C	uc002xgi.2	-	9	1246	c.1167A>G	c.(1165-1167)TCA>TCG	p.S389S	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Silent_p.S389S|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	389	Domain A.|Pocket; binds T and E1A.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)																---	---	---	---
FAM83D	81610	broad.mit.edu	37	20	37580194	37580194	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37580194G>A	uc002xjg.2	+	4	920	c.879G>A	c.(877-879)ACG>ACA	p.T293T		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	263					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)																---	---	---	---
DHX35	60625	broad.mit.edu	37	20	37639048	37639048	+	Splice_Site	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37639048G>A	uc002xjh.2	+	13	1358	c.1347_splice	c.e13+1	p.S449_splice	DHX35_uc010zwa.1_Splice_Site_p.S294_splice|DHX35_uc010zwb.1_Splice_Site_p.S294_splice|DHX35_uc010zwc.1_Splice_Site_p.S418_splice	NM_021931	NP_068750			DEAH (Asp-Glu-Ala-His) box polypeptide 35							catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)																---	---	---	---
DHX35	60625	broad.mit.edu	37	20	37650575	37650575	+	Silent	SNP	C	T	T	rs141540547	byFrequency;by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37650575C>T	uc002xjh.2	+	16	1601	c.1590C>T	c.(1588-1590)CAC>CAT	p.H530H	DHX35_uc010zwa.1_Silent_p.H375H|DHX35_uc010zwb.1_Silent_p.H375H|DHX35_uc010zwc.1_Silent_p.H499H	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	530						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)																---	---	---	---
PTPRT	11122	broad.mit.edu	37	20	40944615	40944615	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40944615C>A	uc002xkg.2	-	12	2071	c.1887G>T	c.(1885-1887)AAG>AAT	p.K629N	PTPRT_uc010ggj.2_Missense_Mutation_p.K629N	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	629	Extracellular (Potential).|Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)																---	---	---	---
STK4	6789	broad.mit.edu	37	20	43629173	43629173	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43629173C>T	uc002xnb.2	+						STK4_uc010ggx.2_Intron|STK4_uc010ggy.2_Intron|STK4_uc010ggw.1_Silent_p.S324S	NM_006282	NP_006273			serine/threonine kinase 4						apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)																---	---	---	---
PIGT	51604	broad.mit.edu	37	20	44052984	44052984	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44052984G>A	uc002xoh.1	+	10	1436	c.1363G>A	c.(1363-1365)GAG>AAG	p.E455K	PIGT_uc010ghf.1_Missense_Mutation_p.E408K|PIGT_uc002xoj.1_Missense_Mutation_p.E388K|PIGT_uc002xok.1_Missense_Mutation_p.E420K|PIGT_uc010zwu.1_Missense_Mutation_p.E193K|PIGT_uc002xoi.1_RNA|PIGT_uc010zwv.1_Missense_Mutation_p.E193K|PIGT_uc010zww.1_Missense_Mutation_p.E399K|PIGT_uc010zwx.1_Missense_Mutation_p.E290K|PIGT_uc010zwy.1_Missense_Mutation_p.E353K|PIGT_uc010zwz.1_Missense_Mutation_p.E193K|PIGT_uc010zxa.1_Missense_Mutation_p.E293K|PIGT_uc002xol.1_Missense_Mutation_p.E244K|PIGT_uc010zxb.1_Missense_Mutation_p.E131K|PIGT_uc002xom.1_Missense_Mutation_p.E47K	NM_015937	NP_057021	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	455	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			pancreas(1)	1		Myeloproliferative disorder(115;0.0122)																---	---	---	---
ZSWIM3	140831	broad.mit.edu	37	20	44506069	44506069	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44506069G>A	uc002xqd.2	+	2	1075	c.872G>A	c.(871-873)CGG>CAG	p.R291Q	ZSWIM3_uc010zxg.1_Missense_Mutation_p.R285Q	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	291							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)																---	---	---	---
MMP9	4318	broad.mit.edu	37	20	44640898	44640898	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44640898G>A	uc002xqz.2	+	7	1139	c.1120G>A	c.(1120-1122)GCT>ACT	p.A374T		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	374	Fibronectin type-II 3.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)													---	---	---	---
EYA2	2139	broad.mit.edu	37	20	45811964	45811964	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:45811964A>G	uc002xsm.2	+	15	1835	c.1461A>G	c.(1459-1461)ATA>ATG	p.I487M	EYA2_uc010ghp.2_Missense_Mutation_p.I408M|EYA2_uc002xsn.2_Missense_Mutation_p.I492M|EYA2_uc002xso.2_Missense_Mutation_p.I487M|EYA2_uc002xsp.2_Missense_Mutation_p.I487M|EYA2_uc002xsq.2_Missense_Mutation_p.I457M	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	487					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)																---	---	---	---
ZMYND8	23613	broad.mit.edu	37	20	45891150	45891150	+	Silent	SNP	C	T	T	rs145166978		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:45891150C>T	uc002xta.1	-	12	1697	c.1443G>A	c.(1441-1443)ACG>ACA	p.T481T	ZMYND8_uc010ghq.1_Silent_p.T158T|ZMYND8_uc010ghr.1_Silent_p.T456T|ZMYND8_uc002xst.1_Intron|ZMYND8_uc002xsu.1_Silent_p.T481T|ZMYND8_uc002xsv.1_Intron|ZMYND8_uc002xsw.1_Silent_p.T233T|ZMYND8_uc002xsx.1_Silent_p.T233T|ZMYND8_uc002xsy.1_Silent_p.T456T|ZMYND8_uc002xsz.1_Silent_p.T418T|ZMYND8_uc010zxy.1_Silent_p.T508T|ZMYND8_uc002xtb.1_Silent_p.T501T|ZMYND8_uc002xss.2_Silent_p.T481T|ZMYND8_uc010zxz.1_Silent_p.T476T|ZMYND8_uc002xtc.1_Silent_p.T501T|ZMYND8_uc002xtd.1_Silent_p.T476T|ZMYND8_uc002xte.1_Silent_p.T481T|ZMYND8_uc010zya.1_Silent_p.T481T|ZMYND8_uc002xtf.1_Silent_p.T501T|ZMYND8_uc002xtg.2_Silent_p.T475T|ZMYND8_uc010ghs.1_Silent_p.T475T	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	481							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)															---	---	---	---
ZFP64	55734	broad.mit.edu	37	20	50701307	50701307	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50701307G>A	uc002xwk.2	-	9	2076	c.1727C>T	c.(1726-1728)ACG>ATG	p.T576M	ZFP64_uc002xwj.2_Missense_Mutation_p.T357M	NM_199427	NP_955459	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform d	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
GNAS	2778	broad.mit.edu	37	20	57415346	57415346	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57415346G>A	uc002xzt.2	+	1	552	c.185G>A	c.(184-186)CGG>CAG	p.R62Q	GNASAS_uc002xzs.1_Intron|GNAS_uc002xzu.3_5'Flank|GNAS_uc010gjq.2_5'Flank	NM_016592	NP_057676	P63092	GNAS2_HUMAN	GNAS complex locus NESP55	62					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)					Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			---	---	---	---
TAF4	6874	broad.mit.edu	37	20	60589624	60589624	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60589624G>A	uc002ybs.2	-	2	1500	c.1500C>T	c.(1498-1500)CCC>CCT	p.P500P		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	500					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)															---	---	---	---
LAMA5	3911	broad.mit.edu	37	20	60921226	60921226	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60921226A>G	uc002ycq.2	-	10	1395	c.1328T>C	c.(1327-1329)CTG>CCG	p.L443P		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	443	Laminin EGF-like 3.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
COL9A3	1299	broad.mit.edu	37	20	61472005	61472005	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61472005C>T	uc002ydm.2	+	32	1979	c.1976C>T	c.(1975-1977)CCG>CTG	p.P659L	COL9A3_uc002ydn.2_Missense_Mutation_p.P153L	NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	659	Triple-helical region 1 (COL1).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)																	---	---	---	---
BHLHE23	128408	broad.mit.edu	37	20	61637673	61637673	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61637673G>A	uc002yeb.2	-	1	715	c.406C>T	c.(406-408)CGC>TGC	p.R136C		NM_080606	NP_542173	Q8NDY6	BHE23_HUMAN	basic helix-loop-helix domain containing, class	136	Helix-loop-helix motif.				transcription, DNA-dependent	nucleus	DNA binding				0																		---	---	---	---
CHRNA4	1137	broad.mit.edu	37	20	61981656	61981656	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61981656C>T	uc002yes.2	-	5	1285	c.1107G>A	c.(1105-1107)CGG>CGA	p.R369R	CHRNA4_uc002yet.1_Silent_p.R193R|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.R298R|CHRNA4_uc002yev.1_Silent_p.R193R|CHRNA4_uc010gkf.1_Silent_p.R193R	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	369	Cytoplasmic (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)													---	---	---	---
PRPF6	24148	broad.mit.edu	37	20	62663288	62663288	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62663288G>A	uc002yho.2	+	20	2732	c.2564G>A	c.(2563-2565)CGG>CAG	p.R855Q	PRPF6_uc002yhp.2_Missense_Mutation_p.R815Q|NCRNA00176_uc002yhq.2_5'Flank|NCRNA00176_uc011abq.1_5'Flank	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	855	HAT 9.				assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)																	---	---	---	---
MYT1	4661	broad.mit.edu	37	20	62871235	62871235	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62871235C>T	uc002yii.2	+	22	3580	c.3216C>T	c.(3214-3216)GCC>GCT	p.A1072A	MYT1_uc002yij.2_Silent_p.A731A|MYT1_uc002yik.2_Silent_p.A38A	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1072					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)																	---	---	---	---
TPTE	7179	broad.mit.edu	37	21	10969092	10969092	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:10969092C>T	uc002yip.1	-	7	524	c.156G>A	c.(154-156)GTG>GTA	p.V52V	TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Intron|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	52					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)														---	---	---	---
NRIP1	8204	broad.mit.edu	37	21	16337566	16337566	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:16337566C>T	uc002yjx.2	-	4	3546	c.2948G>A	c.(2947-2949)GGA>GAA	p.G983E		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	983					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)														---	---	---	---
NCAM2	4685	broad.mit.edu	37	21	22658687	22658687	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:22658687G>A	uc002yld.1	+	4	685	c.436G>A	c.(436-438)GTC>ATC	p.V146I	NCAM2_uc011acb.1_Intron|NCAM2_uc011acc.1_Missense_Mutation_p.V171I	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	146	Ig-like C2-type 2.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)														---	---	---	---
ADAMTS5	11096	broad.mit.edu	37	21	28337870	28337870	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:28337870G>A	uc002ymg.2	-	1	1570	c.841C>T	c.(841-843)CGG>TGG	p.R281W		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	281	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
USP16	10600	broad.mit.edu	37	21	30407165	30407165	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30407165G>A	uc002ymy.2	+	4	450	c.248G>A	c.(247-249)GGC>GAC	p.G83D	USP16_uc002ymx.2_Missense_Mutation_p.G83D|USP16_uc002ymw.2_Missense_Mutation_p.G83D|USP16_uc011acm.1_Missense_Mutation_p.G69D|USP16_uc011acn.1_Intron	NM_006447	NP_006438	Q9Y5T5	UBP16_HUMAN	ubiquitin specific protease 16 isoform a	83	UBP-type.				cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4																		---	---	---	---
C21orf63	59271	broad.mit.edu	37	21	33840140	33840140	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33840140G>A	uc002ypr.1	+	4	1028	c.618G>A	c.(616-618)GAG>GAA	p.E206E	C21orf63_uc002ypq.1_Silent_p.E206E|C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Silent_p.E206E|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Silent_p.E111E	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	206	SUEL-type lectin 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3																		---	---	---	---
KCNJ6	3763	broad.mit.edu	37	21	38997732	38997732	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38997732T>C	uc011aej.1	-	4	1054	c.1001A>G	c.(1000-1002)TAC>TGC	p.Y334C	KCNJ6_uc002ywo.2_Missense_Mutation_p.Y334C	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	334	Cytoplasmic (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)													---	---	---	---
HSF2BP	11077	broad.mit.edu	37	21	45076572	45076572	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45076572A>G	uc002zdi.2	-	3	415	c.83T>C	c.(82-84)CTG>CCG	p.L28P	RRP1B_uc002zdk.2_5'Flank|HSF2BP_uc011aey.1_Intron	NM_007031	NP_008962	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding	28					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.18)														---	---	---	---
C21orf29	54084	broad.mit.edu	37	21	45947252	45947252	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45947252C>T	uc002zfe.1	-	7	1138	c.1072G>A	c.(1072-1074)GAA>AAA	p.E358K	C21orf29_uc010gpv.1_Missense_Mutation_p.E290K	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	358	EAR 1.				cell adhesion	extracellular region	structural molecule activity				0																		---	---	---	---
PRMT2	3275	broad.mit.edu	37	21	48071869	48071869	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:48071869C>T	uc002zjx.2	+						PRMT2_uc002zjw.2_Intron|PRMT2_uc002zjy.2_Intron|PRMT2_uc010gqm.2_Intron|PRMT2_uc011aga.1_Intron|PRMT2_uc011agb.1_Intron|PRMT2_uc011agc.1_Intron|PRMT2_uc002zjz.1_Intron	NM_206962	NP_996845			HMT1 hnRNP methyltransferase-like 1						developmental cell growth|induction of apoptosis|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of androgen receptor signaling pathway	cytosol|nucleus	androgen receptor binding|estrogen receptor binding|histone-arginine N-methyltransferase activity|peroxisome proliferator activated receptor binding|progesterone receptor binding|protein homodimerization activity|retinoic acid receptor binding|signal transducer activity|thyroid hormone receptor binding|transcription coactivator activity			ovary(1)	1	Breast(49;0.247)	Lung NSC(3;0.245)		Epithelial(3;1.03e-07)|OV - Ovarian serous cystadenocarcinoma(3;4.68e-07)|all cancers(3;7.48e-07)|Colorectal(79;0.167)|Lung(125;0.203)|LUSC - Lung squamous cell carcinoma(216;0.23)|READ - Rectum adenocarcinoma(84;0.248)														---	---	---	---
GAB4	128954	broad.mit.edu	37	22	17473042	17473042	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17473042G>T	uc002zlw.2	-	2	307	c.199C>A	c.(199-201)CTG>ATG	p.L67M	GAB4_uc010gqs.1_Missense_Mutation_p.L67M	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	67	PH.									large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)																---	---	---	---
DGCR2	9993	broad.mit.edu	37	22	19048348	19048348	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19048348G>A	uc002zoq.1	-						DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Intron	NM_005137	NP_005128			integral membrane protein DGCR2 precursor						cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)																	---	---	---	---
DGCR14	8220	broad.mit.edu	37	22	19124850	19124850	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19124850C>T	uc002zou.2	-	8	1058	c.1021G>A	c.(1021-1023)GGC>AGC	p.G341S	DGCR14_uc002zot.2_Missense_Mutation_p.G262S|DGCR14_uc002zov.2_RNA	NM_022719	NP_073210	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region protein 14	341					nervous system development	catalytic step 2 spliceosome				ovary(1)	1	Colorectal(54;0.0993)																	---	---	---	---
CLTCL1	8218	broad.mit.edu	37	22	19207438	19207438	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19207438C>T	uc002zpb.2	-	18	2950	c.2875G>A	c.(2875-2877)GTC>ATC	p.V959I	CLTCL1_uc011agv.1_Missense_Mutation_p.V959I|CLTCL1_uc011agw.1_Missense_Mutation_p.V959I	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	959	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)							T	?	ALCL								---	---	---	---
HIRA	7290	broad.mit.edu	37	22	19381879	19381879	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19381879C>T	uc002zpf.1	-	8	1028	c.808G>A	c.(808-810)GCT>ACT	p.A270T	HIRA_uc011agx.1_Missense_Mutation_p.A136T|HIRA_uc010grn.1_Missense_Mutation_p.A270T|HIRA_uc010gro.1_Missense_Mutation_p.A226T|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	270	WD 6.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)																	---	---	---	---
GNB1L	54584	broad.mit.edu	37	22	19808148	19808148	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19808148G>A	uc002zqe.1	-	3	621	c.227C>T	c.(226-228)ACG>ATG	p.T76M	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqf.1_Missense_Mutation_p.T76M	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	76	WD 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)																	---	---	---	---
ARVCF	421	broad.mit.edu	37	22	19960457	19960457	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19960457C>T	uc002zqz.2	-	15	2812	c.2541G>A	c.(2539-2541)GCG>GCA	p.A847A	ARVCF_uc002zqy.2_Silent_p.A363A	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	847					cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)																	---	---	---	---
MED15	51586	broad.mit.edu	37	22	20920907	20920907	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20920907C>T	uc002zsp.2	+	7	924	c.844C>T	c.(844-846)CCC>TCC	p.P282S	MED15_uc002zso.2_Missense_Mutation_p.P211S|MED15_uc002zsq.2_Missense_Mutation_p.P282S|MED15_uc010gso.2_Missense_Mutation_p.P282S|MED15_uc002zsr.2_Missense_Mutation_p.P256S|MED15_uc011ahs.1_Missense_Mutation_p.P256S|MED15_uc002zss.2_Missense_Mutation_p.P201S|MED15_uc011ahu.1_Missense_Mutation_p.P8S	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	282	Pro-rich.			Missing (in Ref. 3; BAB85034).	regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)															---	---	---	---
HIC2	23119	broad.mit.edu	37	22	21800421	21800421	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21800421G>A	uc002zur.3	+	3	1467	c.1237G>A	c.(1237-1239)GGG>AGG	p.G413R	HIC2_uc002zus.3_Missense_Mutation_p.G413R	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	413					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)																---	---	---	---
CCDC116	164592	broad.mit.edu	37	22	21988657	21988657	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21988657C>T	uc002zve.2	+	3	512	c.419C>T	c.(418-420)CCG>CTG	p.P140L	CCDC116_uc011aih.1_Missense_Mutation_p.P140L	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	140										ovary(1)|skin(1)	2	Colorectal(54;0.105)																	---	---	---	---
LOC96610	96610	broad.mit.edu	37	22	22724301	22724301	+	RNA	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22724301G>T	uc011aim.1	+	43		c.4574G>T								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ZNF280A	129025	broad.mit.edu	37	22	22868374	22868374	+	Silent	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22868374A>G	uc002zwe.2	-	2	1834	c.1581T>C	c.(1579-1581)GCT>GCC	p.A527A	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	527					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)														---	---	---	---
BCR	613	broad.mit.edu	37	22	23603147	23603147	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23603147A>G	uc002zww.2	+	3	2068	c.1472A>G	c.(1471-1473)GAC>GGC	p.D491G	BCR_uc002zwx.2_Missense_Mutation_p.D491G|BCR_uc011aiy.1_Missense_Mutation_p.D80G|BCR_uc010gtx.1_5'UTR|uc010gty.2_5'Flank	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	491					regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12								T	ABL1| FGFR1|JAK2 	CML|ALL|AML								---	---	---	---
SEZ6L	23544	broad.mit.edu	37	22	26688613	26688613	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26688613C>T	uc003acb.2	+	2	492	c.336C>T	c.(334-336)GCC>GCT	p.A112A	SEZ6L_uc003acc.2_Silent_p.A112A|SEZ6L_uc011akc.1_Silent_p.A112A|SEZ6L_uc003acd.2_Silent_p.A112A|SEZ6L_uc011akd.1_Silent_p.A112A|SEZ6L_uc003ace.2_Silent_p.A112A|SEZ6L_uc003acf.1_5'UTR|SEZ6L_uc010gvc.1_5'UTR	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	112	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
C1QTNF6	114904	broad.mit.edu	37	22	37578651	37578651	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37578651C>T	uc003aqw.1	-	2	862	c.357G>A	c.(355-357)CCG>CCA	p.P119P	C1QTNF6_uc003aqx.1_Silent_p.P138P|C1QTNF6_uc003aqy.1_Silent_p.P138P|C1QTNF6_uc003aqz.1_Intron	NM_182486	NP_872292	Q9BXI9	C1QT6_HUMAN	C1q and tumor necrosis factor related protein 6	119	Collagen-like.					collagen					0																		---	---	---	---
SOX10	6663	broad.mit.edu	37	22	38373997	38373997	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38373997C>A	uc003aun.1	-	3	852	c.574G>T	c.(574-576)GGT>TGT	p.G192C	POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_Missense_Mutation_p.G192C	NM_006941	NP_008872	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	192						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)																	---	---	---	---
PDGFB	5155	broad.mit.edu	37	22	39626130	39626130	+	Missense_Mutation	SNP	C	T	T	rs146204796		TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39626130C>T	uc003axf.2	-	5	1549	c.560G>A	c.(559-561)CGG>CAG	p.R187Q	PDGFB_uc003axe.2_Missense_Mutation_p.R172Q	NM_002608	NP_002599	P01127	PDGFB_HUMAN	platelet-derived growth factor beta isoform 1	187					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(1)	373	Melanoma(58;0.04)				Becaplermin(DB00102)			T	COL1A1	DFSP								---	---	---	---
MGAT3	4248	broad.mit.edu	37	22	39884756	39884756	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39884756G>A	uc003axv.3	+	2	1643	c.1404G>A	c.(1402-1404)ACG>ACA	p.T468T	MGAT3_uc010gxy.2_Silent_p.T468T	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	468	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)																	---	---	---	---
TNRC6B	23112	broad.mit.edu	37	22	40662758	40662758	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40662758G>T	uc011aor.1	+	5	2735	c.2524G>T	c.(2524-2526)GGC>TGC	p.G842C	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Missense_Mutation_p.G842C|TNRC6B_uc003ayo.2_Missense_Mutation_p.G646C	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	842	Pro-rich.				gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0																		---	---	---	---
MKL1	57591	broad.mit.edu	37	22	40814610	40814610	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40814610G>T	uc003ayv.1	-	9	2039	c.1832C>A	c.(1831-1833)CCT>CAT	p.P611H	MKL1_uc003ayw.1_Missense_Mutation_p.P611H|MKL1_uc010gye.1_Missense_Mutation_p.P611H|MKL1_uc010gyf.1_Missense_Mutation_p.P561H	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	611	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5								T	RBM15	acute megakaryocytic leukemia								---	---	---	---
TOB2	10766	broad.mit.edu	37	22	41832815	41832815	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41832815C>T	uc003azz.1	-	2	1242	c.535G>A	c.(535-537)GCC>ACC	p.A179T		NM_016272	NP_057356	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	179					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				ovary(1)	1																		---	---	---	---
TTLL1	25809	broad.mit.edu	37	22	43435868	43435868	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43435868G>T	uc003bdi.2	-	11	1427	c.1186C>A	c.(1186-1188)CTG>ATG	p.L396M	TTLL1_uc010gzh.2_Missense_Mutation_p.L367M|TTLL1_uc003bdj.2_Missense_Mutation_p.L282M|TTLL1_uc003bdh.2_Missense_Mutation_p.L358M	NM_012263	NP_036395	O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	396					protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			skin(1)	1		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)														---	---	---	---
EFCAB6	64800	broad.mit.edu	37	22	44011785	44011785	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:44011785G>A	uc003bdy.1	-	21	2698	c.2483C>T	c.(2482-2484)GCG>GTG	p.A828V	EFCAB6_uc003bdz.1_Missense_Mutation_p.A676V|EFCAB6_uc010gzi.1_Missense_Mutation_p.A676V|EFCAB6_uc010gzj.1_Intron	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	828					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)																---	---	---	---
PNPLA5	150379	broad.mit.edu	37	22	44287040	44287040	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:44287040C>T	uc003beg.2	-	2	425	c.328G>A	c.(328-330)GTC>ATC	p.V110I	PNPLA5_uc011aqc.1_5'UTR|PNPLA5_uc003beh.2_Intron	NM_138814	NP_620169	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	110	Patatin.				lipid catabolic process		hydrolase activity				0		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)																---	---	---	---
FBLN1	2192	broad.mit.edu	37	22	45970515	45970515	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45970515G>A	uc003bgj.1	+	15	1969	c.1822G>A	c.(1822-1824)GAG>AAG	p.E608K		NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	608					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)														---	---	---	---
PPARA	5465	broad.mit.edu	37	22	46631044	46631044	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46631044C>A	uc003bgw.1	+	9	1440	c.1174C>A	c.(1174-1176)CTA>ATA	p.L392I	PPARA_uc003bgx.1_Missense_Mutation_p.L392I|PPARA_uc010hab.1_Missense_Mutation_p.L392I|PPARA_uc003bhb.1_Missense_Mutation_p.L392I|PPARA_uc010hac.1_Missense_Mutation_p.L189I	NM_005036	NP_005027	Q07869	PPARA_HUMAN	peroxisome proliferative activated receptor,	392	Ligand-binding.|Required for heterodimerization with RXRA.				fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)													---	---	---	---
CELSR1	9620	broad.mit.edu	37	22	46794456	46794456	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46794456C>G	uc003bhw.1	-	11	5491	c.5491G>C	c.(5491-5493)GTC>CTC	p.V1831L	CELSR1_uc011arc.1_Missense_Mutation_p.V152L	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1831	Extracellular (Potential).|Laminin G-like 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)														---	---	---	---
HDAC10	83933	broad.mit.edu	37	22	50686680	50686680	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50686680G>T	uc003bkg.2	-	12	1428	c.1055C>A	c.(1054-1056)CCG>CAG	p.P352Q	HDAC10_uc003bke.2_Missense_Mutation_p.P78Q|HDAC10_uc003bkf.2_Missense_Mutation_p.P78Q|HDAC10_uc010hav.2_Missense_Mutation_p.P332Q|HDAC10_uc003bkh.2_Missense_Mutation_p.P145Q|HDAC10_uc003bki.2_Missense_Mutation_p.P302Q|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_5'UTR	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	352					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
PLXNB2	23654	broad.mit.edu	37	22	50714329	50714329	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50714329A>G	uc003bkv.3	-	36	5507	c.5401T>C	c.(5401-5403)TAC>CAC	p.Y1801H	PLXNB2_uc003bkt.1_Missense_Mutation_p.Y593H|PLXNB2_uc003bku.1_Missense_Mutation_p.Y786H	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1801	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)												OREG0026679	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NLGN4X	57502	broad.mit.edu	37	X	5827153	5827153	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:5827153A>C	uc010ndh.2	-	4	1254	c.753T>G	c.(751-753)TTT>TTG	p.F251L	NLGN4X_uc004crp.2_Missense_Mutation_p.F271L|NLGN4X_uc004crq.2_Missense_Mutation_p.F251L|NLGN4X_uc010ndi.2_Missense_Mutation_p.F288L|NLGN4X_uc004crr.2_Missense_Mutation_p.F251L|NLGN4X_uc010ndj.2_Missense_Mutation_p.F251L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	251	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4																		---	---	---	---
AP1S2	8905	broad.mit.edu	37	X	15870579	15870579	+	Silent	SNP	T	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15870579T>G	uc004cxi.2	-	2	359	c.69A>C	c.(67-69)TCA>TCC	p.S23S	AP1S2_uc004cxh.2_Silent_p.S23S|AP1S2_uc010nex.2_Silent_p.S65S|AP1S2_uc011mis.1_Silent_p.S65S|AP1S2_uc011mit.1_Silent_p.S65S|AP1S2_uc011miu.1_Silent_p.S65S	NM_003916	NP_003907	P56377	AP1S2_HUMAN	adaptor-related protein complex 1 sigma 2	23					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	AP-type membrane coat adaptor complex|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein transporter activity				0	Hepatocellular(33;0.183)																	---	---	---	---
CTPS2	56474	broad.mit.edu	37	X	16709659	16709659	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16709659C>T	uc004cxk.2	-						CTPS2_uc004cxl.2_Intron|CTPS2_uc004cxm.2_Intron	NM_001144002	NP_001137474			cytidine triphosphate synthase II						glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
PHKA2	5256	broad.mit.edu	37	X	18913264	18913264	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18913264T>C	uc004cyv.3	-	31	3758	c.3328A>G	c.(3328-3330)ACC>GCC	p.T1110A	PHKA2_uc004cyu.3_Missense_Mutation_p.T416A|PHKA2_uc010nfe.1_Missense_Mutation_p.T142A|PHKA2_uc010nff.1_RNA	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1110					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)																	---	---	---	---
ZFX	7543	broad.mit.edu	37	X	24229411	24229411	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:24229411A>G	uc004dbf.2	+	9	2594	c.2336A>G	c.(2335-2337)GAG>GGG	p.E779G	ZFX_uc004dbe.2_3'UTR|ZFX_uc011mjv.1_Missense_Mutation_p.E818G|ZFX_uc010nfz.2_Missense_Mutation_p.E435G	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	779	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2																		---	---	---	---
MAGEB1	4112	broad.mit.edu	37	X	30268697	30268697	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30268697C>T	uc004dcc.2	+	4	407	c.87C>T	c.(85-87)CAC>CAT	p.H29H	MAGEB1_uc004dcd.2_Silent_p.H29H|MAGEB1_uc004dce.2_Silent_p.H29H	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	29											0																		---	---	---	---
DMD	1756	broad.mit.edu	37	X	31164461	31164461	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:31164461C>T	uc004dda.1	-	76	11112	c.10868G>A	c.(10867-10869)AGC>AAC	p.S3623N	DMD_uc004dcq.1_Missense_Mutation_p.S894N|DMD_uc004dcr.1_Missense_Mutation_p.S1043N|DMD_uc004dcs.1_Missense_Mutation_p.S1053N|DMD_uc004dct.1_Missense_Mutation_p.S1163N|DMD_uc004dcu.1_Missense_Mutation_p.S1163N|DMD_uc004dcv.1_Missense_Mutation_p.S1150N|DMD_uc004dcw.2_Missense_Mutation_p.S2279N|DMD_uc004dcx.2_Missense_Mutation_p.S2282N|DMD_uc004dcz.2_Missense_Mutation_p.S3500N|DMD_uc004dcy.1_Missense_Mutation_p.S3619N|DMD_uc004ddb.1_Missense_Mutation_p.S3615N|DMD_uc004dcm.1_Missense_Mutation_p.S555N|DMD_uc004dcn.1_Missense_Mutation_p.S542N|DMD_uc004dco.1_Missense_Mutation_p.S555N|DMD_uc004dcp.1_Missense_Mutation_p.S542N|DMD_uc011mkb.1_Missense_Mutation_p.S445N	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3623					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)																---	---	---	---
CXorf36	79742	broad.mit.edu	37	X	45051067	45051067	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:45051067G>T	uc004dgg.2	-	2	502	c.427C>A	c.(427-429)CGT>AGT	p.R143S	CXorf36_uc004dgi.3_Missense_Mutation_p.R143S	NM_176819	NP_789789	Q9H7Y0	CX036_HUMAN	hypothetical protein LOC79742 isoform 1	143						extracellular region				lung(1)	1																		---	---	---	---
SLC9A7	84679	broad.mit.edu	37	X	46513103	46513103	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:46513103G>A	uc004dgu.1	-	8	1093	c.1085C>T	c.(1084-1086)GCG>GTG	p.A362V		NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	362	Helical; (Potential).				regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2																		---	---	---	---
UBA1	7317	broad.mit.edu	37	X	47072270	47072270	+	Intron	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47072270G>A	uc004dhj.3	+						UBA1_uc004dhk.3_Intron|UBA1_uc004dhm.2_Intron	NM_153280	NP_695012			ubiquitin-activating enzyme E1						cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1																		---	---	---	---
CDK16	5127	broad.mit.edu	37	X	47085414	47085414	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47085414G>A	uc004dho.2	+	8	1176	c.780G>A	c.(778-780)ATG>ATA	p.M260I	CDK16_uc011mli.1_Missense_Mutation_p.M266I|CDK16_uc011mlj.1_Missense_Mutation_p.M260I|CDK16_uc011mlk.1_Missense_Mutation_p.M260I|CDK16_uc011mll.1_Missense_Mutation_p.M334I	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	260	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	47662698	47662698	+	IGR	SNP	C	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47662698C>A								LOC100133957 (142922 upstream) : ZNF81 (33603 downstream)																																			---	---	---	---
GRIPAP1	56850	broad.mit.edu	37	X	48837734	48837734	+	Intron	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48837734G>T	uc004dly.1	-						GRIPAP1_uc004dlz.2_Intron|GRIPAP1_uc004dma.2_Intron	NM_020137	NP_064522			GRIP1 associated protein 1 isoform 1							early endosome				breast(2)|kidney(1)	3																		---	---	---	---
MAGED1	9500	broad.mit.edu	37	X	51638686	51638686	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:51638686A>G	uc004dpm.2	+	3	678	c.583A>G	c.(583-585)ACC>GCC	p.T195A	MAGED1_uc004dpn.2_Missense_Mutation_p.T251A|MAGED1_uc004dpo.2_Missense_Mutation_p.T195A	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	195					apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)														Multiple Myeloma(10;0.10)			---	---	---	---
SSX7	280658	broad.mit.edu	37	X	52677309	52677309	+	Splice_Site	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:52677309A>G	uc004dqx.1	-	6	625	c.466_splice	c.e6+1	p.G156_splice		NM_173358	NP_775494			synovial sarcoma, X breakpoint 7						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			skin(1)	1	Ovarian(276;0.236)																	---	---	---	---
LAS1L	81887	broad.mit.edu	37	X	64749749	64749749	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64749749A>G	uc004dwa.1	-	5	596	c.524T>C	c.(523-525)TTT>TCT	p.F175S	LAS1L_uc004dwc.1_Missense_Mutation_p.F175S|LAS1L_uc004dwd.1_Missense_Mutation_p.F133S	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	175						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4																		---	---	---	---
MIR325	442899	broad.mit.edu	37	X	76225900	76225900	+	RNA	SNP	A	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:76225900A>C	hsa-mir-325|MI0000824	-			c.27A>C			uc010nlv.1_Intron																	0																		---	---	---	---
PGAM4	441531	broad.mit.edu	37	X	77224579	77224579	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:77224579T>C	uc004ecy.1	-	1	557	c.557A>G	c.(556-558)CAT>CGT	p.H186R	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	186		By similarity.			glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0																		---	---	---	---
CYLC1	1538	broad.mit.edu	37	X	83141586	83141586	+	Silent	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:83141586G>T	uc004eei.1	+	5	1971	c.1950G>T	c.(1948-1950)CTG>CTT	p.L650L		NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	650	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5																		---	---	---	---
PCDH11X	27328	broad.mit.edu	37	X	91133388	91133388	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:91133388G>T	uc004efk.1	+	2	2994	c.2149G>T	c.(2149-2151)GGA>TGA	p.G717*	PCDH11X_uc004efl.1_Nonsense_Mutation_p.G717*|PCDH11X_uc004efo.1_Nonsense_Mutation_p.G717*|PCDH11X_uc010nmv.1_Nonsense_Mutation_p.G717*|PCDH11X_uc004efm.1_Nonsense_Mutation_p.G717*|PCDH11X_uc004efn.1_Nonsense_Mutation_p.G717*|PCDH11X_uc004efh.1_Nonsense_Mutation_p.G717*|PCDH11X_uc004efj.1_Nonsense_Mutation_p.G717*	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	717	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2																		---	---	---	---
ARL13A	392509	broad.mit.edu	37	X	100243452	100243452	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100243452G>C	uc004ego.2	+	8	946	c.830G>C	c.(829-831)AGG>ACG	p.R277T	ARL13A_uc011mrf.1_Missense_Mutation_p.R277T|ARL13A_uc010nng.2_Intron	NM_001012990	NP_001013008	Q5H913	AR13A_HUMAN	ADP-ribosylation factor-like 13 isoform a	277							GTP binding			ovary(1)	1																		---	---	---	---
BHLHB9	80823	broad.mit.edu	37	X	102004167	102004167	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102004167G>A	uc010nog.2	+	4	815	c.244G>A	c.(244-246)GGC>AGC	p.G82S	BHLHB9_uc011mrq.1_Missense_Mutation_p.G82S|BHLHB9_uc011mrr.1_Missense_Mutation_p.G82S|BHLHB9_uc011mrs.1_Missense_Mutation_p.G82S|BHLHB9_uc011mrt.1_Missense_Mutation_p.G82S|BHLHB9_uc004ejo.2_Missense_Mutation_p.G82S|BHLHB9_uc011mru.1_Missense_Mutation_p.G82S|BHLHB9_uc011mrv.1_Missense_Mutation_p.G82S	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	82						cytoplasm|nucleus	binding			ovary(2)	2																		---	---	---	---
KIAA1210	57481	broad.mit.edu	37	X	118281430	118281430	+	Intron	SNP	C	T	T	rs148525771	by1000genomes	TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118281430C>T	uc004era.3	-							NM_020721	NP_065772			hypothetical protein LOC57481											ovary(4)|skin(1)	5																		---	---	---	---
C1GALT1C1	29071	broad.mit.edu	37	X	119760722	119760722	+	Silent	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119760722G>A	uc004esy.2	-	3	647	c.300C>T	c.(298-300)TTC>TTT	p.F100F	C1GALT1C1_uc004esz.2_Silent_p.F100F	NM_152692	NP_689905	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	100	Lumenal (Potential).					integral to membrane					0																		---	---	---	---
THOC2	57187	broad.mit.edu	37	X	122759791	122759791	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:122759791T>A	uc004etu.2	-	25	3061	c.3029A>T	c.(3028-3030)AAT>ATT	p.N1010I	THOC2_uc004etw.1_5'Flank	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1010					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3																		---	---	---	---
ODZ1	10178	broad.mit.edu	37	X	123695633	123695633	+	Silent	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:123695633T>C	uc004euj.2	-	14	2386	c.2322A>G	c.(2320-2322)CGA>CGG	p.R774R	ODZ1_uc011muj.1_Silent_p.R773R|ODZ1_uc010nqy.2_Silent_p.R774R	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	774	EGF-like 8.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23																		---	---	---	---
XPNPEP2	7512	broad.mit.edu	37	X	128896746	128896746	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:128896746G>T	uc004eut.1	+	19	1984	c.1740G>T	c.(1738-1740)AAG>AAT	p.K580N		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	580					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0																		---	---	---	---
AIFM1	9131	broad.mit.edu	37	X	129272624	129272624	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129272624G>A	uc004evg.2	-	9	1089	c.911C>T	c.(910-912)ACG>ATG	p.T304M	AIFM1_uc011mur.1_5'Flank|AIFM1_uc011mus.1_Missense_Mutation_p.T304M|AIFM1_uc004evh.2_Missense_Mutation_p.T300M|AIFM1_uc004evi.2_Intron|AIFM1_uc004evk.2_RNA	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	304	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5																		---	---	---	---
USP26	83844	broad.mit.edu	37	X	132161368	132161368	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:132161368C>T	uc010nrm.1	-	6	1351	c.881G>A	c.(880-882)TGC>TAC	p.C294Y	USP26_uc011mvf.1_Missense_Mutation_p.C294Y	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	294					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
FAM127A	8933	broad.mit.edu	37	X	134166475	134166475	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134166475G>A	uc004eyd.2	+	1	143	c.62G>A	c.(61-63)CGT>CAT	p.R21H	uc004eye.1_RNA	NM_001078171	NP_001071639	A6ZKI3	F127A_HUMAN	family with sequence similarity 127, member A	21											0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ZNF449	203523	broad.mit.edu	37	X	134494414	134494414	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134494414C>T	uc004eys.2	+	5	1135	c.970C>T	c.(970-972)CGA>TGA	p.R324*	ZNF449_uc004eyt.2_Nonsense_Mutation_p.R204*|ZNF449_uc004eyu.2_Nonsense_Mutation_p.R130*	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	324	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
GPR112	139378	broad.mit.edu	37	X	135494507	135494507	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135494507C>T	uc004ezu.1	+	24	9310	c.9019C>T	c.(9019-9021)CGA>TGA	p.R3007*	GPR112_uc010nsb.1_Nonsense_Mutation_p.R2802*	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	3007	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
SPANXN3	139067	broad.mit.edu	37	X	142596637	142596637	+	3'UTR	SNP	T	C	C			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:142596637T>C	uc004fbw.2	-	2						NM_001009609	NP_001009609			SPANX-N3 protein											ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
GABRA3	2556	broad.mit.edu	37	X	151366116	151366116	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151366116C>T	uc010ntk.1	-	8	1160	c.920G>A	c.(919-921)CGT>CAT	p.R307H		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	307	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)													---	---	---	---
PNMA3	29944	broad.mit.edu	37	X	152226635	152226635	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:152226635G>A	uc004fhc.2	+	2	1559	c.1223G>A	c.(1222-1224)CGG>CAG	p.R408Q	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	408	Arg-rich.				apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
HAUS7	55559	broad.mit.edu	37	X	152721027	152721027	+	Silent	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:152721027C>T	uc004fho.1	-	8	1491	c.933G>A	c.(931-933)ACG>ACA	p.T311T	HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA|HAUS7_uc004fhn.1_Silent_p.T311T|HAUS7_uc004fhp.1_RNA	NM_017518	NP_059988	Q99871	HAUS7_HUMAN	HAUS augmin-like complex subunit 7	311					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding				0																		---	---	---	---
IL9R	3581	broad.mit.edu	37	X	155235745	155235745	+	Intron	SNP	C	T	T			TCGA-CG-5728-01A-11D-1600-08	TCGA-CG-5728-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:155235745C>T	uc004fnv.1	+						IL9R_uc010nvn.2_Intron|IL9R_uc004fnu.1_Intron	NM_002186	NP_002177			interleukin 9 receptor precursor						cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)																	---	---	---	---
