Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CASZ1	54897	broad.mit.edu	37	1	10720553	10720553	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr1:10720553C>T	uc001aro.2	-	6	866	c.546G>A	c.(544-546)ATG>ATA	p.M182I	CASZ1_uc001arp.1_Missense_Mutation_p.M182I|CASZ1_uc009vmx.2_Missense_Mutation_p.M206I|CASZ1_uc001arq.1_Missense_Mutation_p.M41I	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GGAACTCGGTCATGGTGGAGG	0.652000													5	21	---	---	---	---	0	0	0.029380	0	0
KTI12	112970	broad.mit.edu	37	1	52499429	52499429	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr1:52499429G>A	uc001ctj.1	-	1	44	c.5C>T	c.(4-6)CCG>CTG	p.P2L	TXNDC12_uc001cti.2_Intron	NM_138417	NP_612426	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated	2							ATP binding			central_nervous_system(2)	2						CACCACGAGCGGCATCCTCTC	0.657000													4	11	---	---	---	---	0	0	0.014758	0	0
BCAR3	8412	broad.mit.edu	37	1	94054850	94054850	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr1:94054850C>T	uc001dpz.2	-	5	888	c.613G>A	c.(613-615)GTT>ATT	p.V205I	BCAR3_uc001dqa.2_Missense_Mutation_p.V205I|BCAR3_uc001dqb.2_Missense_Mutation_p.V205I|BCAR3_uc001dpy.2_Missense_Mutation_p.V114I|uc009wdn.2_5'Flank	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	205	SH2.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		AGTCGCAGAACTGTCCGGTTG	0.582000													4	22	---	---	---	---	0	0	0.014758	0	0
TRIM46	80128	broad.mit.edu	37	1	155149705	155149705	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr1:155149705G>A	uc001fhs.1	+	5	931	c.848G>A	c.(847-849)GGA>GAA	p.G283E	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc010pez.1_Missense_Mutation_p.G270E|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Missense_Mutation_p.G283E|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Missense_Mutation_p.G157E|TRIM46_uc001fhu.1_Missense_Mutation_p.G260E|TRIM46_uc009wpg.1_Missense_Mutation_p.G270E|TRIM46_uc001fhv.3_Missense_Mutation_p.G270E|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	283						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TACATCCTGGGAAACCAGGAC	0.612000													35	126	---	---	---	---	0	0	0.025465	0	0
ASPM	259266	broad.mit.edu	37	1	197115496	197115496	+	Silent	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr1:197115496C>T	uc001gtu.2	-	1	329	c.72G>A	c.(70-72)CTG>CTA	p.L24L	ASPM_uc001gtv.2_Silent_p.L24L|ASPM_uc001gtw.3_5'UTR	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	24					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						cggggccccgcagccccgcgg	0.214000													6	21	---	---	---	---	0	0	0.029380	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453000													4	67	---	---	---	---	0	0	0.009096	0	0
ZDHHC16	84287	broad.mit.edu	37	10	99213324	99213324	+	Silent	SNP	G	C	C			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr10:99213324G>C	uc001knj.2	+	7	943	c.594G>C	c.(592-594)CGG>CGC	p.R198R	ZDHHC16_uc001knp.2_Intron|ZDHHC16_uc001knk.2_Silent_p.R198R|ZDHHC16_uc001knl.2_Silent_p.R198R|ZDHHC16_uc001knm.2_Silent_p.R133R|ZDHHC16_uc001knn.2_Intron|ZDHHC16_uc010qow.1_Silent_p.R198R|ZDHHC16_uc009xvq.2_RNA|ZDHHC16_uc001kno.2_Silent_p.R198R|ZDHHC16_uc009xvr.2_Silent_p.R198R	NM_198046	NP_932163	Q969W1	ZDH16_HUMAN	Abl-philin 2 isoform 1	198	Cytoplasmic (Potential).|DHHC-type.				apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		ATAACCATCGGTACTTCTTCT	0.483000													5	168	---	---	---	---	0	0	0.014758	0	0
VTI1A	143187	broad.mit.edu	37	10	114298090	114298090	+	Splice_Site	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr10:114298090G>A	uc001kzy.2	+	5	803	c.427_splice	c.e5+1	p.E143_splice	VTI1A_uc001kzz.2_Splice_Site_p.E143_splice	NM_145206	NP_660207	Q96AJ9	VTI1A_HUMAN	SNARE Vti1a-beta protein						intracellular protein transport|retrograde transport, endosome to Golgi	SNARE complex	protein transporter activity|SNAP receptor activity			ovary(1)	1		Colorectal(252;0.0314)|Breast(234;0.183)		Epithelial(162;0.0126)|all cancers(201;0.0487)		GTGGAAACCGGTAAGAATTCT	0.453000													19	61	---	---	---	---	0	0	0.038395	0	0
SESN3	143686	broad.mit.edu	37	11	94963999	94963999	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr11:94963999G>A	uc001pfk.1	-	1	248	c.26C>T	c.(25-27)TCG>TTG	p.S9L	SESN3_uc010rug.1_Intron|SESN3_uc001pfl.2_Missense_Mutation_p.S9L	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	9					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		GGCGGCGGCCGACGGGCTGCC	0.751000													5	9	---	---	---	---	0	0	0.014758	0	0
C11orf53	341032	broad.mit.edu	37	11	111154827	111154827	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr11:111154827G>A	uc001plc.2	+	3	181	c.34G>A	c.(34-36)GGT>AGT	p.G12S		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	12											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		AGGTTACTACGGTGTCAGAAG	0.502000											OREG0021325	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	178	---	---	---	---	0	0	0.029380	0	0
DNAJC22	79962	broad.mit.edu	37	12	49742735	49742735	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr12:49742735G>A	uc001rua.2	+	2	481	c.80G>A	c.(79-81)AGG>AAG	p.R27K	DNAJC22_uc001rub.2_Missense_Mutation_p.R27K	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	27					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						TACCTGGGAAGGGACAGCCAC	0.652000													4	78	---	---	---	---	0	0	0.009096	0	0
C15orf52	388115	broad.mit.edu	37	15	40630052	40630052	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr15:40630052C>T	uc001zlh.3	-	6	704	c.688G>A	c.(688-690)GAG>AAG	p.E230K	C15orf52_uc001zli.1_Missense_Mutation_p.E162K|C15orf52_uc010ucn.1_Missense_Mutation_p.E20K	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	230										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CAGCCCGCCTCCGGGGGCTCC	0.697000													3	13	---	---	---	---	0	0	0.009096	0	0
ZNF710	374655	broad.mit.edu	37	15	90617455	90617455	+	Silent	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr15:90617455C>T	uc002bov.1	+	4	1881	c.1758C>T	c.(1756-1758)CTC>CTT	p.L586L		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	586	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			AGTTTAATCTCAAGGGCAACC	0.592000													18	33	---	---	---	---	0	0	0.038395	0	0
SPSB3	90864	broad.mit.edu	37	16	1828539	1828539	+	Silent	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr16:1828539G>A	uc002cmr.2	-	2	234	c.201C>T	c.(199-201)GGC>GGT	p.G67G	SPSB3_uc002cms.2_5'UTR|SPSB3_uc002cmt.2_5'UTR|SPSB3_uc002cmu.2_Silent_p.G67G|SPSB3_uc002cmv.2_5'UTR|SPSB3_uc010uvm.1_Silent_p.G122G	NM_080861	NP_543137	Q6PJ21	SPSB3_HUMAN	splA/ryanodine receptor domain and SOCS box	67					intracellular signal transduction						0						AGAAGGACTCGCCGGTCACGG	0.677000													16	58	---	---	---	---	0	0	0.012319	0	0
RUNDC2A	84127	broad.mit.edu	37	16	12121194	12121194	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr16:12121194C>T	uc002dbw.1	+	4	202	c.140C>T	c.(139-141)GCC>GTC	p.A47V		NM_032167	NP_115543	Q9HA26	RUN2A_HUMAN	RUN domain containing 2A	47	RUN.									ovary(1)	1						TGTCTGTGTGCCCAGTTTGAA	0.572000			T	CIITA	PMBL|Hodgkin Lymphona|								27	57	---	---	---	---	0	0	0.027356	0	0
KIAA0174	9798	broad.mit.edu	37	16	71954709	71954709	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr16:71954709G>A	uc002fbj.1	+	7	747	c.464G>A	c.(463-465)GGA>GAA	p.G155E	KIAA0174_uc010cgh.1_Missense_Mutation_p.G155E|KIAA0174_uc002fbk.1_Missense_Mutation_p.G142E|KIAA0174_uc002fbm.1_Missense_Mutation_p.G142E|KIAA0174_uc002fbl.1_Missense_Mutation_p.G142E|KIAA0174_uc002fbn.1_5'UTR|KIAA0174_uc010cgi.1_Intron|KIAA0174_uc010cgj.1_Missense_Mutation_p.G74E|KIAA0174_uc010vml.1_5'Flank|KIAA0174_uc010vmk.1_Intron			P53990	IST1_HUMAN	SubName: Full=cDNA FLJ32696 fis, clone TESTI2000358; SubName: Full=cDNA FLJ77725;	142	Interaction with VPS37B.|Interaction with CHMP1A and CHMP1B.				cell cycle|cell division	cytoplasmic membrane-bounded vesicle|ER-Golgi intermediate compartment	protein binding			ovary(1)	1						AACCAGATTGGAACTGTGAAT	0.413000													3	83	---	---	---	---	0	0	0.004672	0	0
SLC16A13	201232	broad.mit.edu	37	17	6939881	6939881	+	Silent	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr17:6939881C>T	uc002geh.2	+	1	488	c.180C>T	c.(178-180)ATC>ATT	p.I60I		NM_201566	NP_963860	Q7RTY0	MOT13_HUMAN	monocarboxylate transporter 13	60	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(1)|skin(1)	2						CCATAGGAATCGCGGTGCAGC	0.637000													5	42	---	---	---	---	0	0	0.014758	0	0
TP53	7157	broad.mit.edu	37	17	7578275	7578275	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	26	---	---	---	---	0	0	0.004482	0	0
Unknown	0	broad.mit.edu	37	17	18967379	18967379	+	IGR	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr17:18967379C>T								GRAP (17043 upstream) : GRAPL (63403 downstream)																							tcggggttttcggtgctctac	0.090000													9	32	---	---	---	---	0	0	0.006214	0	0
PCGF2	7703	broad.mit.edu	37	17	36896590	36896591	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr17:36896590_36896591CC>TT	uc002hqp.1	-	3	308_309	c.65_66GG>AA	c.(64-66)GGG>GAA	p.G22E	PCGF2_uc002hqn.1_Missense_Mutation_p.G22E|PCGF2_uc002hqo.1_Missense_Mutation_p.G22E|PCGF2_uc010cvo.1_Intron|PCGF2_uc002hqq.1_Missense_Mutation_p.G22E	NM_007144	NP_009075	P35227	PCGF2_HUMAN	ring finger protein 110	22	RING-type.				negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2	Breast(7;9.07e-22)					TGAAGTACCCCCCGCAGAGGGC	0.624000													10	57	---	---	---	---	0	0	0.004672	0	0
PIP4K2B	8396	broad.mit.edu	37	17	36926732	36926732	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr17:36926732G>A	uc002hqs.2	-	9	1608	c.1127C>T	c.(1126-1128)ACA>ATA	p.T376I	PIP4K2B_uc010cvp.2_5'Flank	NM_003559	NP_003550	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	376	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			ovary(1)	1						TTTCTTCTTTGTATCGTATGG	0.542000													7	148	---	---	---	---	0	0	0.038147	0	0
ITGA3	3675	broad.mit.edu	37	17	48156836	48156836	+	Missense_Mutation	SNP	G	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr17:48156836G>T	uc010dbl.2	+	21	3085	c.2621G>T	c.(2620-2622)CGG>CTG	p.R874L	ITGA3_uc010dbm.2_Missense_Mutation_p.R874L	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	874	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						CAGCGCAGGCGGCGACAGCTG	0.627000													4	66	---	---	---	---	0.00909568	0.00955622	0.009096	1	0
NAPG	8774	broad.mit.edu	37	18	10526109	10526109	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr18:10526109C>T	uc002kon.2	+	1	237	c.10C>T	c.(10-12)CAG>TAG	p.Q4*	NAPG_uc010wzr.1_5'UTR|NAPG_uc002koo.2_5'UTR	NM_003826	NP_003817	Q99747	SNAG_HUMAN	N-ethylmaleimide-sensitive factor attachment	4					cellular membrane fusion|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein complex assembly|protein stabilization	membrane|membrane fraction|mitochondrion	protein binding				0						GATGGCGGCTCAGAAGATAAA	0.597000													3	28	---	---	---	---	0	0	0.004672	0	0
LOC644669	644669	broad.mit.edu	37	18	15323340	15323340	+	RNA	SNP	A	G	G			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr18:15323340A>G	uc002ktd.1	-	3		c.119T>C				NR_027417				Homo sapiens cDNA FLJ40312 fis, clone TESTI2029880.												0						CTTATGGCCAATAAAAGTGGT	0.299000													2	5	---	---	---	---	0	0	0.004672	0	0
ZNF91	7644	broad.mit.edu	37	19	23544777	23544777	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr19:23544777G>A	uc002nre.2	-	4	1117	c.1004C>T	c.(1003-1005)TCA>TTA	p.S335L	ZNF91_uc010xrj.1_Missense_Mutation_p.S303L	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	335	C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGCAAGGGTTGAAGAACGGCT	0.383000													20	75	---	---	---	---	0	0	0.043863	0	0
IL29	282618	broad.mit.edu	37	19	39787080	39787080	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr19:39787080G>A	uc002okv.2	+	1	116	c.19G>A	c.(19-21)GTG>ATG	p.V7M		NM_172140	NP_742152	Q8IU54	IL29_HUMAN	interleukin 29 precursor	7					defense response to virus|negative regulation of cell proliferation|negative regulation of interleukin-13 production|negative regulation of interleukin-5 production|negative regulation of memory T cell differentiation|negative regulation of transcription, DNA-dependent|negative regulation of type 2 immune response|positive regulation of immune response|positive regulation of interferon-gamma production|positive regulation of MHC class I biosynthetic process|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of STAT protein	extracellular space|interleukin-28 receptor complex	cytokine activity|interleukin-28 receptor binding				0	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			AGCTTGGACCGTGGTGCTGGT	0.567000													19	60	---	---	---	---	0	0	0.012319	0	0
ID2	3398	broad.mit.edu	37	2	8822537	8822537	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr2:8822537C>T	uc010yiu.1	+	3	737	c.242C>T	c.(241-243)TCG>TTG	p.S81L	ID2_uc002qza.2_Missense_Mutation_p.S81L	NM_002166	NP_002157	Q02363	ID2_HUMAN	inhibitor of DNA binding 2	81					cellular senescence|embryonic digestive tract morphogenesis|endodermal digestive tract morphogenesis|epithelial cell differentiation involved in mammary gland alveolus development|mammary gland epithelial cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of neuron differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|neuron fate commitment|positive regulation of blood pressure|positive regulation of cell cycle arrest|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent	protein complex	protein binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GCCCTGGACTCGCATCCCACT	0.587000													16	41	---	---	---	---	0	0	0.043863	0	0
CCDC80	151887	broad.mit.edu	37	3	112357200	112357200	+	Missense_Mutation	SNP	G	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr3:112357200G>T	uc003dzf.2	-	2	1771	c.1553C>A	c.(1552-1554)TCT>TAT	p.S518Y	CCDC80_uc011bhv.1_Missense_Mutation_p.S518Y|CCDC80_uc003dzg.2_Missense_Mutation_p.S518Y|CCDC80_uc003dzh.1_Missense_Mutation_p.S518Y	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	518	Lys-rich.									ovary(2)	2						CTCCAGCTGAGAGGCAGTAGG	0.448000													24	53	---	---	---	---	1.96895e-08	2.23867e-08	0.016522	1	0
MCM2	4171	broad.mit.edu	37	3	127335823	127335823	+	Silent	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr3:127335823C>T	uc003ejp.2	+	10	1692	c.1635C>T	c.(1633-1635)TTC>TTT	p.F545F	MCM2_uc011bkm.1_Silent_p.F415F|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Silent_p.F498F	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	545	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						GAGCCATCTTCACCACTGGCC	0.607000													46	75	---	---	---	---	0	0	0.014410	0	0
PLXND1	23129	broad.mit.edu	37	3	129324718	129324718	+	Silent	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr3:129324718G>A	uc003emx.2	-	1	865	c.765C>T	c.(763-765)TTC>TTT	p.F255F		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	255	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						GGTTGAGGTCGAAGGTGAAGA	0.657000													3	15	---	---	---	---	0	0	0.004672	0	0
RPL9	6133	broad.mit.edu	37	4	39460022	39460023	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr4:39460022_39460023GG>AA	uc003gub.2	-	1	185_186	c.37_38CC>TT	c.(37-39)CCA>TTA	p.P13L	RPL9_uc003guc.2_Missense_Mutation_p.P13L|RPL9_uc011byk.1_RNA|RPL9_uc011byl.1_Missense_Mutation_p.P13L|RPL9_uc003gud.1_Missense_Mutation_p.P13L|LIAS_uc003gue.3_5'Flank|LIAS_uc011bym.1_5'Flank|LIAS_uc003guf.2_5'Flank|LIAS_uc003gug.2_5'Flank|LIAS_uc003guh.2_5'Flank	NM_001024921	NP_001020092	P32969	RL9_HUMAN	ribosomal protein L9	13					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|nucleolus|ribosome	rRNA binding|structural constituent of ribosome			skin(1)	1						ACCATTTTCTGGAATGTCGACA	0.470000													11	45	---	---	---	---	0	0	0.004672	0	0
RUFY3	22902	broad.mit.edu	37	4	71634264	71634264	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr4:71634264C>A	uc003hfq.2	+	5	1177	c.582C>A	c.(580-582)TAC>TAA	p.Y194*	RUFY3_uc003hfp.3_Nonsense_Mutation_p.Y254*|RUFY3_uc011cax.1_Nonsense_Mutation_p.Y212*|RUFY3_uc003hfr.2_Nonsense_Mutation_p.Y194*|RUFY3_uc011cay.1_Nonsense_Mutation_p.Y130*	NM_014961	NP_055776	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 2	194	RUN.				negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			GTGAATTCTACGAACCCAATG	0.388000													4	104	---	---	---	---	1.024e-07	1.14854e-07	0.014758	1	0
INTU	27152	broad.mit.edu	37	4	128554328	128554328	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr4:128554328G>A	uc003ifk.1	+	1	209	c.139G>A	c.(139-141)GAT>AAT	p.D47N	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	47										ovary(1)	1						AGCGAGTAGCGATTATGAGTA	0.488000													5	65	---	---	---	---	0	0	0.021553	0	0
USP38	84640	broad.mit.edu	37	4	144109022	144109022	+	Silent	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr4:144109022G>A	uc003ijb.2	+	2	1260	c.726G>A	c.(724-726)CAG>CAA	p.Q242Q	USP38_uc003ija.3_Silent_p.Q242Q|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	242					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					GCCTTGTGCAGCATATTCCTC	0.388000													3	49	---	---	---	---	0	0	0.004672	0	0
CASP3	836	broad.mit.edu	37	4	185550615	185550615	+	Silent	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr4:185550615G>A	uc003iwh.2	-	8	908	c.645C>T	c.(643-645)TTC>TTT	p.F215F	CASP3_uc003iwg.2_Missense_Mutation_p.S175L|CASP3_uc003iwi.2_Silent_p.F215F	NM_004346	NP_004337	P42574	CASP3_HUMAN	caspase 3 preproprotein	215					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|negative regulation of apoptosis|nerve growth factor receptor signaling pathway|nuclear fragmentation involved in apoptotic nuclear change|proteolysis|response to tumor necrosis factor	cytosol|mitochondrion|nucleoplasm|plasma membrane	cysteine-type endopeptidase activity|protein binding			kidney(1)	1		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.057)|all_hematologic(60;0.0592)		all cancers(43;2.05e-27)|Epithelial(43;4.27e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.04e-11)|Colorectal(24;2e-05)|STAD - Stomach adenocarcinoma(60;2.35e-05)|GBM - Glioblastoma multiforme(59;4.94e-05)|COAD - Colon adenocarcinoma(29;0.00017)|BRCA - Breast invasive adenocarcinoma(30;0.000218)|LUSC - Lung squamous cell carcinoma(40;0.00904)|READ - Rectum adenocarcinoma(43;0.161)	Melatonin(DB01065)|Minocycline(DB01017)|Simvastatin(DB00641)	GCGACTGGATGAACCAGGAGC	0.393000													15	42	---	---	---	---	0	0	0.038395	0	0
CTNND2	1501	broad.mit.edu	37	5	10973762	10973762	+	Missense_Mutation	SNP	G	C	C			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr5:10973762G>C	uc003jfa.1	-	22	3626	c.3481C>G	c.(3481-3483)CAG>GAG	p.Q1161E	CTNND2_uc010itt.2_Missense_Mutation_p.Q1070E|CTNND2_uc011cmy.1_Missense_Mutation_p.Q824E|CTNND2_uc011cmz.1_Missense_Mutation_p.Q728E|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.Q753E	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1161					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GTGGAATTCTGAAATGGCTGG	0.532000													19	47	---	---	---	---	0	0	0.043863	0	0
MYO10	4651	broad.mit.edu	37	5	16689986	16689986	+	Silent	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr5:16689986G>A	uc003jft.3	-	28	4311	c.3843C>T	c.(3841-3843)ATC>ATT	p.I1281I	MYO10_uc011cnc.1_Silent_p.I160I|MYO10_uc011cnd.1_Silent_p.I638I|MYO10_uc011cne.1_Silent_p.I638I|MYO10_uc010itx.2_Silent_p.I904I	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1281	PH 1.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CGGCCATAATGATGTCGATCC	0.468000													3	49	---	---	---	---	0	0	0.009096	0	0
ATG12	9140	broad.mit.edu	37	5	115177522	115177522	+	5'Flank	SNP	C	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr5:115177522C>A	uc003krh.2	-						AP3S1_uc003krl.2_5'Flank|AP3S1_uc003krk.2_5'Flank|AP3S1_uc003krm.2_5'Flank|ATG12_uc003kri.2_5'Flank|ATG12_uc003krj.2_Splice_Site	NM_004707	NP_004698	O94817	ATG12_HUMAN	APG12 autophagy 12-like						autophagic vacuole assembly|negative regulation of type I interferon production	pre-autophagosomal structure membrane	protein binding				0		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;7.59e-08)|Epithelial(69;7.05e-07)|all cancers(49;3.11e-05)		CCAGTTAGGCCGCTGGCTCGG	0.652000													6	3	---	---	---	---	3.59834e-05	3.92976e-05	0.021553	1	0
IRF1	3659	broad.mit.edu	37	5	131822017	131822017	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr5:131822017G>A	uc003kxa.2	-	7	827	c.593C>T	c.(592-594)CCA>CTA	p.P198L	C5orf56_uc010jds.1_Missense_Mutation_p.G60R|IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Missense_Mutation_p.P198L|IRF1_uc010jdt.1_Missense_Mutation_p.P198L	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	198					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		AACTTCCACTGGGATGTGCCA	0.582000													4	88	---	---	---	---	0	0	0.009096	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573408	140573408	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr5:140573408C>T	uc003lix.2	+	1	1457	c.1283C>T	c.(1282-1284)ACA>ATA	p.T428I		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	428	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACTTGGGGACACCCAGGCTG	0.537000													33	46	---	---	---	---	0	0	0.013726	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156747	26156747	+	Silent	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr6:26156747C>T	uc003ngq.2	+	1	189	c.129C>T	c.(127-129)CTC>CTT	p.L43L	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	43	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						TGTCCGAGCTCATTACTAAAG	0.627000													13	38	---	---	---	---	0	0	0.013537	0	0
TRIM10	10107	broad.mit.edu	37	6	30121959	30121959	+	Silent	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr6:30121959G>A	uc003npo.3	-	7	1309	c.1233C>T	c.(1231-1233)TTC>TTT	p.F411F	TRIM10_uc003npn.2_Intron	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	411	B30.2/SPRY.					cytoplasm	zinc ion binding				0						GAGCCGAGACGAAGCCCCAAG	0.672000													11	23	---	---	---	---	0	0	0.016723	0	0
FGD2	221472	broad.mit.edu	37	6	36983609	36983609	+	Missense_Mutation	SNP	G	C	C			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr6:36983609G>C	uc010jwp.1	+	9	1266	c.1095G>C	c.(1093-1095)AGG>AGC	p.R365S	FGD2_uc003ong.2_Missense_Mutation_p.R87S|FGD2_uc011dtv.1_5'UTR	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	365	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						TCCAGGTGAGGACCCGCATCG	0.612000													2	6	---	---	---	---	0	0	0.004672	0	0
TREM1	54210	broad.mit.edu	37	6	41254385	41254385	+	Silent	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr6:41254385C>T	uc003oqf.1	-	1	73	c.9G>A	c.(7-9)AAG>AAA	p.K3K	TREM1_uc003oqg.1_Silent_p.K3K	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	3					blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	AGAGCCTGGTCTTCCTCATCC	0.582000													12	52	---	---	---	---	0	0	0.020292	0	0
NMBR	4829	broad.mit.edu	37	6	142409595	142409595	+	Silent	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr6:142409595G>A	uc003qiu.2	-	1	342	c.201C>T	c.(199-201)ATC>ATT	p.I67I		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	67	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		TGGTGATGAAGATCTTCACCA	0.602000													15	24	---	---	---	---	0	0	0.024245	0	0
SQLE	6713	broad.mit.edu	37	8	126033114	126033114	+	Splice_Site	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr8:126033114G>A	uc011liq.1	+	10	2458	c.1532_splice	c.e10+1	p.V511_splice		NM_003129	NP_003120	Q14534	ERG1_HUMAN	squalene epoxidase						cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			ovary(1)|breast(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	TGCTTTCTGTGTAAGTTGTGA	0.383000													6	17	---	---	---	---	0	0	0.021553	0	0
KANK1	23189	broad.mit.edu	37	9	732477	732477	+	Silent	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr9:732477G>A	uc003zgl.1	+	10	3754	c.3105G>A	c.(3103-3105)GAG>GAA	p.E1035E	KANK1_uc003zgm.2_3'UTR|KANK1_uc003zgn.1_Silent_p.E1035E|KANK1_uc003zgs.1_Silent_p.E877E|KANK1_uc010mgx.1_5'UTR|KANK1_uc010mgy.1_5'UTR|KANK1_uc003zgt.1_5'Flank	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	1035					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TTGAAGAAGAGGAGGAGGAGG	0.468000													4	102	---	---	---	---	0	0	0.009096	0	0
FREM1	158326	broad.mit.edu	37	9	14824915	14824915	+	Missense_Mutation	SNP	C	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr9:14824915C>A	uc003zlm.2	-	11	2547	c.1957G>T	c.(1957-1959)GTC>TTC	p.V653F	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	653	CSPG 4.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GTTTCCTTGACAACCAAATGC	0.418000													8	35	---	---	---	---	7.48243e-07	8.28055e-07	0.006214	1	0
PPP6C	5537	broad.mit.edu	37	9	127915858	127915858	+	Missense_Mutation	SNP	C	G	G			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr9:127915858C>G	uc004bpg.3	-	6	844	c.623G>C	c.(622-624)AGT>ACT	p.S208T	PPP6C_uc010mwv.2_Missense_Mutation_p.S245T|PPP6C_uc010mww.2_Missense_Mutation_p.S186T|PPP6C_uc011lzr.1_Missense_Mutation_p.S61T	NM_002721	NP_002712	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit isoform	208					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			ovary(1)|skin(1)	2						TCCTCGGGGACTGATAGCCCA	0.438000													14	10	---	---	---	---	0	0	0.016723	0	0
C9orf116	138162	broad.mit.edu	37	9	138391667	138391667	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr9:138391667C>T	uc004cft.1	-	1	95	c.31G>A	c.(31-33)GAG>AAG	p.E11K	C9orf116_uc004cfs.1_Missense_Mutation_p.E11K|C9orf116_uc004cfu.1_RNA|MRPS2_uc004cfv.3_5'Flank|MRPS2_uc004cfw.3_5'Flank|MRPS2_uc004cfx.3_5'Flank|MRPS2_uc010nat.2_5'Flank	NM_001048265	NP_001041730	Q5BN46	CI116_HUMAN	hypothetical protein LOC138162 isoform 1	11											0				OV - Ovarian serous cystadenocarcinoma(145;7.39e-08)|Epithelial(140;5.19e-07)|all cancers(34;1.04e-05)		GCCACAGGCTCCGCGCACGCT	0.697000													4	5	---	---	---	---	0	0	0.014758	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071154	141071154	+	Missense_Mutation	SNP	T	C	C	rs150819761	by1000genomes	TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr9:141071154T>C	uc004com.2	+	4	818	c.557T>C	c.(556-558)GTC>GCC	p.V186A	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						GTGAACATGGTCCCGTTTCCC	0.632000													8	30	---	---	---	---	0	0	0.004482	0	0
GAGE2A	729447	broad.mit.edu	37	X	49355893	49355893	+	Missense_Mutation	SNP	C	G	G	rs147803166	by1000genomes	TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chrX:49355893C>G	uc004doi.3	+	3	272	c.175C>G	c.(175-177)CAG>GAG	p.Q59E	GAGE1_uc011mnu.1_Intron|GAGE1_uc004doj.2_Intron	NM_001127212	NP_001120684	Q6NT46	GAG2A_HUMAN	G antigen 2A	59											0	Ovarian(276;0.236)					TCAGGAGGGACAGGATGAGGG	0.443000													6	631	---	---	---	---	0	0	0.038147	0	0
DCX	1641	broad.mit.edu	37	X	110653602	110653602	+	Missense_Mutation	SNP	C	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chrX:110653602C>A	uc004epd.2	-	2	440	c.268G>T	c.(268-270)GAC>TAC	p.D90Y	DCX_uc011msv.1_Missense_Mutation_p.D90Y|DCX_uc004epe.2_Missense_Mutation_p.D9Y|DCX_uc004epf.2_Missense_Mutation_p.D9Y|DCX_uc004epg.2_Missense_Mutation_p.D9Y	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	90					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						TCTCTTTCGTCAAAGTGTCCA	0.507000													27	112	---	---	---	---	1.16021e-09	1.33746e-09	0.034045	1	0
CT47B1	643311	broad.mit.edu	37	X	120008779	120008779	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chrX:120008779G>A	uc011muc.1	-	1	1001	c.746C>T	c.(745-747)CCG>CTG	p.P249L		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	249											0						CTCTGAGGTCGGTTCCTCTGC	0.547000													55	100	---	---	---	---	0	0	0.014410	0	0
GABRA3	2556	broad.mit.edu	37	X	151336929	151336929	+	Missense_Mutation	SNP	G	T	T			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chrX:151336929G>T	uc010ntk.1	-	10	1490	c.1250C>A	c.(1249-1251)TCC>TAC	p.S417Y		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	417	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGCGCCCTTGGAGATGGTGGA	0.557000													7	248	---	---	---	---	0.00198382	0.00211099	0.029380	1	0
Unknown	0	broad.mit.edu	37	10	121312535	121312536	+	IGR	INS	-	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr10:121312535_121312536insA								RGS10 (10313 upstream) : TIAL1 (20442 downstream)																							gcaagactctcaaaaaaaaaaa	0.000													3	3	---	---	---	---					
KIAA0284	283638	broad.mit.edu	37	14	105352853	105352854	+	Frame_Shift_Ins	INS	-	G	G			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr14:105352853_105352854insG	uc010axb.2	+	12	2501_2502	c.2277_2278insG	c.(2275-2280)CCCGAGfs	p.P759fs	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Frame_Shift_Ins_p.P689fs|KIAA0284_uc001yps.2_Frame_Shift_Ins_p.P665fs|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	759_760						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		GCCGAGGCCCCGAGCCAGGGGT	0.723													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	17	19091624	19091625	+	IGR	INS	-	A	A			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr17:19091624_19091625insA								GRAPL (29476 upstream) : EPN2 (49065 downstream)																							TCCTGCTTGGCATGTCGCGAGA	0.480													4	2	---	---	---	---					
Unknown	0	broad.mit.edu	37	17	26772648	26772649	+	IGR	DEL	GC	-	-			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr17:26772648_26772649delGC								SLC46A1 (39420 upstream) : SLC13A2 (28015 downstream)																							GGACACACATGCtttttttttt	0.218													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	21	16055951	16055966	+	IGR	DEL	AAAGAAGAAAGGAAGA	-	-	rs146806868	by1000genomes	TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr21:16055951_16055966delAAAGAAGAAAGGAAGA								SAMSN1 (100228 upstream) : NRIP1 (277590 downstream)																							ggaaggaaggaaagaagaaaggaagaaaggaaggta	0.074													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	21	30274390	30274390	+	IGR	DEL	T	-	-			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr21:30274390delT								N6AMT1 (16697 upstream) : RNF160 (26076 downstream)																							ttttttttccttttttttttt	0.184													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	3	110401054	110401054	+	IGR	DEL	T	-	-	rs113398685		TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr3:110401054delT								None (None upstream) : PVRL3 (389811 downstream)																							CTTTGACTTCTTTTTTTTTTT	0.408													2	4	---	---	---	---					
SLC22A4	6583	broad.mit.edu	37	5	131676327	131676327	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr5:131676327delT	uc003kwq.2	+	9	1679	c.1514delT	c.(1513-1515)CTTfs	p.L505fs	uc003kwr.3_Intron	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	505	Helical; Name=12; (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	ATCCTCACCCTTTTTTTCCCT	0.418													7	229	---	---	---	---					
Unknown	0	broad.mit.edu	37	6	79424144	79424144	+	IGR	DEL	A	-	-	rs111390657		TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr6:79424144delA								None (None upstream) : IRAK1BP1 (153045 downstream)																							AAACACTGACAAAAAAAAAAA	0.393													4	9	---	---	---	---					
Unknown	0	broad.mit.edu	37	6	155028499	155028499	+	IGR	DEL	A	-	-	rs147940473		TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr6:155028499delA								CNKSR3 (196746 upstream) : RBM16 (26013 downstream)																							gactccatctaaaaaaaaaaa	0.169													3	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	7	56244094	56244094	+	IGR	DEL	A	-	-			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr7:56244094delA								PSPH (60004 upstream) : DKFZp434L192 (319822 downstream)																							TCCCCCACCTAAAAAAAAACA	0.448													8	172	---	---	---	---					
DPY19L4	286148	broad.mit.edu	37	8	95738654	95738657	+	Frame_Shift_Del	DEL	GAAA	-	-			TCGA-EM-A1YB-01A-11D-A14W-08	TCGA-EM-A1YB-10A-01D-A14W-08									Somatic	Phase_I	Capture				Illumina GAIIx	d01545d4-8162-4d14-9c1f-b86832e1c2d4	9443fcf8-ae1f-4a09-adf8-503bb03f63db	g.chr8:95738654_95738657delGAAA	uc003ygx.2	+	2	236_239	c.112_115delGAAA	c.(112-117)GAAAGAfs	p.E38fs		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	38_39						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					TCCAATTCCTGAAAGAGCTCCAAA	0.328													8	29	---	---	---	---					
