Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LSP1	4046	broad.mit.edu	37	11	1907970	1907970	+	Silent	SNP	C	T	T			TCGA-ET-A3DT-01A-11D-A19J-08	TCGA-ET-A3DT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	71d4fa4b-f805-4b31-957e-defc6913a3c5	79039652-38f5-4155-8ee4-bf4312bde77d	g.chr11:1907970C>T	uc001lui.2	+	8	901	c.726C>T	c.(724-726)GGC>GGT	p.G242G	LSP1_uc001luj.2_Silent_p.G370G|LSP1_uc001luk.2_Silent_p.G180G|LSP1_uc001lul.2_Silent_p.G180G|LSP1_uc001lum.2_Silent_p.G180G	NM_002339	NP_002330	P33241	LSP1_HUMAN	lymphocyte-specific protein 1 isoform 1	242					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			large_intestine(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		AGACCGCTGGCCGGACCCCCA	0.602													8	84	---	---	---	---	0	0	0.038147	0	0
NCOR1	9611	broad.mit.edu	37	17	15973810	15973810	+	Silent	SNP	T	A	A			TCGA-ET-A3DT-01A-11D-A19J-08	TCGA-ET-A3DT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	71d4fa4b-f805-4b31-957e-defc6913a3c5	79039652-38f5-4155-8ee4-bf4312bde77d	g.chr17:15973810T>A	uc002gpo.2	-	31	4422	c.4182A>T	c.(4180-4182)TCA>TCT	p.S1394S	NCOR1_uc002gpn.2_Silent_p.S1410S|NCOR1_uc002gpp.1_Silent_p.S1301S|NCOR1_uc002gpm.2_5'Flank|NCOR1_uc010vwb.1_5'UTR|NCOR1_uc010coy.2_Silent_p.S302S|NCOR1_uc010vwc.1_Silent_p.S205S	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1394	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAGATTGACCTGAGTTGTTGT	0.428													21	61	---	---	---	---	0	0	0.069288	0	0
GRM2	2912	broad.mit.edu	37	3	51746681	51746681	+	Missense_Mutation	SNP	G	T	T			TCGA-ET-A3DT-01A-11D-A19J-08	TCGA-ET-A3DT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	71d4fa4b-f805-4b31-957e-defc6913a3c5	79039652-38f5-4155-8ee4-bf4312bde77d	g.chr3:51746681G>T	uc010hlv.2	+	3	882	c.643G>T	c.(643-645)GAC>TAC	p.D215Y	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	215	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GTCTGAGGGCGACTATGGCGA	0.602													24	62	---	---	---	---	6.36457e-07	7.77892e-07	0.091800	1	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-ET-A3DT-01A-11D-A19J-08	TCGA-ET-A3DT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	71d4fa4b-f805-4b31-957e-defc6913a3c5	79039652-38f5-4155-8ee4-bf4312bde77d	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				14	40	---	---	---	---	0	0	0.020292	0	0
Unknown	0	broad.mit.edu	37	1	154350594	154350594	+	IGR	DEL	T	-	-			TCGA-ET-A3DT-01A-11D-A19J-08	TCGA-ET-A3DT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	71d4fa4b-f805-4b31-957e-defc6913a3c5	79039652-38f5-4155-8ee4-bf4312bde77d	g.chr1:154350594delT								ATP8B2 (26815 upstream) : IL6R (27075 downstream)																							TCTTTTTTTCTTTTTTTTTTT	0.338													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	43063100	43063101	+	IGR	INS	-	AAA	AAA	rs34202394		TCGA-ET-A3DT-01A-11D-A19J-08	TCGA-ET-A3DT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	71d4fa4b-f805-4b31-957e-defc6913a3c5	79039652-38f5-4155-8ee4-bf4312bde77d	g.chr10:43063100_43063101insAAA								ZNF37B (14820 upstream) : ZNF33B (6532 downstream)																							TTTGGAGCCAGAAAAAAAAAAA	0.218													3	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	11	49104678	49104678	+	IGR	DEL	T	-	-	rs111997628		TCGA-ET-A3DT-01A-11D-A19J-08	TCGA-ET-A3DT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	71d4fa4b-f805-4b31-957e-defc6913a3c5	79039652-38f5-4155-8ee4-bf4312bde77d	g.chr11:49104678delT								OR4A47 (593406 upstream) : FOLH1 (63510 downstream)																							AGCTTCCTTGttttttttttt	0.428													6	11	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	98910246	98910246	+	IGR	DEL	A	-	-	rs139074595		TCGA-ET-A3DT-01A-11D-A19J-08	TCGA-ET-A3DT-10A-01D-A19M-08									Somatic	Phase_I	Capture				Illumina GAIIx	71d4fa4b-f805-4b31-957e-defc6913a3c5	79039652-38f5-4155-8ee4-bf4312bde77d	g.chr9:98910246delA								NCRNA00092 (126209 upstream) : HSD17B3 (87343 downstream)																							CCATCTCCTGAAAAAAAAAAA	0.313													5	6	---	---	---	---					
