Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MST1P2	11209	broad.mit.edu	37	1	16974243	16974243	+	RNA	SNP	G	C	C	rs142213352	by1000genomes	TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr1:16974243G>C	uc009vow.2	+	5		c.1053G>C			MST1P2_uc010ocg.1_RNA|MST1P2_uc010och.1_Intron|MST1P2_uc010oci.1_RNA|MST1P2_uc001azk.2_Intron|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_Intron|MST1P2_uc001azm.3_Intron					Homo sapiens cDNA FLJ53774 complete cds, moderately similar to Hepatocyte growth factor-like protein precursor.												0						GATCTCAGCTGTCGCTCGGGG	0.652000													4	33	---	---	---	---	0	0	0.014758	0	0
NPR1	4881	broad.mit.edu	37	1	153660571	153660571	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr1:153660571G>A	uc001fcs.3	+	15	2712	c.2291G>A	c.(2290-2292)CGG>CAG	p.R764Q	NPR1_uc010pdz.1_Missense_Mutation_p.R510Q|NPR1_uc010pea.1_Missense_Mutation_p.R242Q	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	764	Cytoplasmic (Potential).|Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CCCCCCTTCCGGCCCTCCCTG	0.657000													26	44	---	---	---	---	0	0	0.027356	0	0
KCNN3	3782	broad.mit.edu	37	1	154841828	154841828	+	Missense_Mutation	SNP	C	T	T			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr1:154841828C>T	uc001ffp.2	-	1	927	c.613G>A	c.(613-615)GGC>AGC	p.G205S	KCNN3_uc009wox.1_Missense_Mutation_p.G205S	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	210						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			AGGGGTTGGCCCTCAGTCTCG	0.632000													32	33	---	---	---	---	0	0	0.013726	0	0
CACNA1G	8913	broad.mit.edu	37	17	48680555	48680555	+	Silent	SNP	G	A	A			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr17:48680555G>A	uc002irk.1	+	21	4536	c.4164G>A	c.(4162-4164)CCG>CCA	p.P1388P	CACNA1G_uc002iri.1_Silent_p.P1388P|CACNA1G_uc002irj.1_Silent_p.P1365P|CACNA1G_uc002irl.1_Silent_p.P1365P|CACNA1G_uc002irm.1_Silent_p.P1365P|CACNA1G_uc002irn.1_Silent_p.P1365P|CACNA1G_uc002iro.1_Silent_p.P1365P|CACNA1G_uc002irp.1_Silent_p.P1388P|CACNA1G_uc002irq.1_Silent_p.P1365P|CACNA1G_uc002irr.1_Silent_p.P1388P|CACNA1G_uc002irs.1_Silent_p.P1388P|CACNA1G_uc002irt.1_Silent_p.P1388P|CACNA1G_uc002irv.1_Silent_p.P1388P|CACNA1G_uc002irw.1_Silent_p.P1365P|CACNA1G_uc002iru.1_Silent_p.P1365P|CACNA1G_uc002irx.1_Silent_p.P1301P|CACNA1G_uc002iry.1_Silent_p.P1301P|CACNA1G_uc002irz.1_Silent_p.P1301P|CACNA1G_uc002isa.1_Silent_p.P1301P|CACNA1G_uc002isb.1_Silent_p.P1301P|CACNA1G_uc002isc.1_Silent_p.P1301P|CACNA1G_uc002isd.1_Silent_p.P1301P|CACNA1G_uc002ise.1_Silent_p.P1301P|CACNA1G_uc002isf.1_Silent_p.P1301P|CACNA1G_uc002isg.1_Silent_p.P1301P|CACNA1G_uc002ish.1_Silent_p.P1301P|CACNA1G_uc002isi.1_Silent_p.P1278P|CACNA1G_uc002isj.2_Silent_p.P112P	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1388	III.|Helical; Name=S4 of repeat III; (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCCTGCGCCCGCTCAGGTGAC	0.637000													10	17	---	---	---	---	0	0	0.008291	0	0
CGB1	114335	broad.mit.edu	37	19	49539494	49539494	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr19:49539494G>A	uc002plx.2	-	2	299	c.76C>T	c.(76-78)CGG>TGG	p.R26W	CGB_uc010yad.1_Intron|SNAR-G1_uc010emp.1_5'Flank	NM_033377	NP_203695	A6NKQ9	CGB1_HUMAN	chorionic gonadotropin, beta polypeptide 1	58						extracellular region	hormone activity				0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		GGGCGGCACCGTGGCCGAAGC	0.652000													6	89	---	---	---	---	0	0	0.003080	0	0
TIA1	7072	broad.mit.edu	37	2	70439917	70439917	+	Silent	SNP	C	T	T			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr2:70439917C>T	uc002sgj.3	-	13	1312	c.1095G>A	c.(1093-1095)GGG>GGA	p.G365G	TIA1_uc002sgk.3_Silent_p.G354G|TIA1_uc002sgl.3_RNA	NM_022173	NP_071505	P31483	TIA1_HUMAN	TIA1 cytotoxic granule-associated RNA binding	365					apoptosis|induction of apoptosis|regulation of nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|poly(A) RNA binding|protein binding				0						TGCCATTTTGCCCTTGAGGCG	0.502000													4	130	---	---	---	---	0	0	0.009096	0	0
ANKRD5	63926	broad.mit.edu	37	20	10025188	10025188	+	Silent	SNP	C	T	T			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr20:10025188C>T	uc002wno.2	+	5	1086	c.693C>T	c.(691-693)TTC>TTT	p.F231F	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Silent_p.F231F|ANKRD5_uc010gbz.2_Silent_p.F42F	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	231	ANK 3.						calcium ion binding			ovary(1)|breast(1)	2						GAGGCTTTTTCGATGTAATAA	0.358000													4	101	---	---	---	---	0	0	0.014758	0	0
FRG1B	284802	broad.mit.edu	37	20	29628278	29628278	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr20:29628278G>A	uc010ztl.1	+	3	222	c.190G>A	c.(190-192)GCA>ACA	p.A64T	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.A16T					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						ATGCAATGAAGCAGGGGACAT	0.373000													5	96	---	---	---	---	0	0	0.004482	0	0
SLC2A9	56606	broad.mit.edu	37	4	9982230	9982230	+	Missense_Mutation	SNP	C	T	T	rs147289616	byFrequency	TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr4:9982230C>T	uc003gmc.2	-	5	728	c.667G>A	c.(667-669)GAG>AAG	p.E223K	SLC2A9_uc003gmd.2_Missense_Mutation_p.E194K	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	223	Extracellular (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						CCCAGCAGCTCGGGCAGGCCC	0.567000													5	49	---	---	---	---	0	0	0.021553	0	0
FIP1L1	81608	broad.mit.edu	37	4	54310242	54310242	+	Silent	SNP	T	C	C			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr4:54310242T>C	uc003gzy.2	+	15	1443	c.1257T>C	c.(1255-1257)CGT>CGC	p.R419R	PDGFRA_uc003haa.2_Intron|FIP1L1_uc011bzu.1_Silent_p.R413R|FIP1L1_uc003gzz.2_Silent_p.R345R|FIP1L1_uc003hab.2_Silent_p.R384R|FIP1L1_uc003hac.2_Silent_p.R173R|FIP1L1_uc010ign.2_RNA|FIP1L1_uc003had.2_Missense_Mutation_p.V4A|FIP1L1_uc003hae.2_Missense_Mutation_p.V4A	NM_030917	NP_112179	Q6UN15	FIP1_HUMAN	FIP1 like 1 isoform 1	419					mRNA processing	nucleus	RNA binding			ovary(1)|skin(1)	2			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			ATGATAGTCGTTCTGCACGTG	0.303000			T	PDGFRA	idiopathic hypereosinophilic syndrome								3	82	---	---	---	---	0	0	0.014758	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68939712	68939712	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr4:68939712G>A	uc003hdt.1	-	4	347	c.298C>T	c.(298-300)CGA>TGA	p.R100*	LOC550112_uc003hdl.3_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	100	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GAAGAATGTCGAAATATCCTA	0.244000													10	16	---	---	---	---	0	0	0.008291	0	0
PRDM9	56979	broad.mit.edu	37	5	23526762	23526762	+	Missense_Mutation	SNP	C	T	T			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr5:23526762C>T	uc003jgo.2	+	11	1747	c.1565C>T	c.(1564-1566)GCA>GTA	p.A522V		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	522					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TCAAGAATTGCAAAAGTCAAG	0.433000										HNSCC(3;0.000094)			5	71	---	---	---	---	0	0	0.014758	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181052	140181052	+	Silent	SNP	A	C	C			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr5:140181052A>C	uc003lhf.2	+	1	270	c.270A>C	c.(268-270)ATA>ATC	p.I90I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.I90I	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	90	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATAGACCGCGAGG	0.592000													5	284	---	---	---	---	0	0	0.021553	0	0
STC2	8614	broad.mit.edu	37	5	172752921	172752921	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr5:172752921G>A	uc003mco.1	-	2	1554	c.244C>T	c.(244-246)CAT>TAT	p.H82Y	STC2_uc003mcn.1_5'UTR	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	82					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CAAATCCCATGTAAGCCCCGA	0.468000													12	373	---	---	---	---	0	0	0.013537	0	0
PMS2	5395	broad.mit.edu	37	7	6018249	6018249	+	Silent	SNP	A	G	G	rs140779135	by1000genomes	TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr7:6018249A>G	uc003spl.2	-	13	2340	c.2253T>C	c.(2251-2253)TTT>TTC	p.F751F	PMS2_uc003spj.2_Silent_p.F645F|PMS2_uc003spk.2_Silent_p.F616F|PMS2_uc011jwl.1_Silent_p.F616F|PMS2_uc010ktg.2_Silent_p.F440F|PMS2_uc010kte.2_Silent_p.F350F|PMS2_uc010ktf.1_Intron	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	751					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		TAACAAAATCAAAGCCATTCT	0.224000			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				4	26	---	---	---	---	0	0	0.009096	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				31	59	---	---	---	---	0	0	0.010818	0	0
IARS	3376	broad.mit.edu	37	9	95030578	95030578	+	Missense_Mutation	SNP	G	C	C			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr9:95030578G>C	uc004art.1	-	14	1566	c.1309C>G	c.(1309-1311)CCA>GCA	p.P437A	IARS_uc004ars.1_Missense_Mutation_p.P282A|IARS_uc004aru.3_Missense_Mutation_p.P437A|IARS_uc010mqr.2_Missense_Mutation_p.P327A|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	437					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	ACCAACTCTGGGACCCTGCAA	0.418000													15	139	---	---	---	---	0	0	0.024245	0	0
TRO	7216	broad.mit.edu	37	X	54954164	54954164	+	Missense_Mutation	SNP	C	T	T			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chrX:54954164C>T	uc004dtq.2	+	11	1935	c.1828C>T	c.(1828-1830)CGC>TGC	p.R610C	TRO_uc004dts.2_Missense_Mutation_p.R610C|TRO_uc004dtr.2_Missense_Mutation_p.R610C|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_RNA|TRO_uc004dtv.2_Missense_Mutation_p.R213C|TRO_uc011mok.1_Missense_Mutation_p.R141C|TRO_uc004dtw.2_Missense_Mutation_p.R213C|TRO_uc004dtx.2_5'UTR	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	610	MAGE.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						CTGGGGCTTGCGCTCCTACCA	0.483000													4	93	---	---	---	---	0	0	0.009096	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298907	125298907	+	Missense_Mutation	SNP	G	A	A			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chrX:125298907G>A	uc004euk.1	-	1	1028	c.1001C>T	c.(1000-1002)CCG>CTG	p.P334L		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	334										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GCGCTGGCGCGGATCCAGGAA	0.617000													49	81	---	---	---	---	0	0	0.014410	0	0
PHF6	84295	broad.mit.edu	37	X	133527567	133527567	+	Missense_Mutation	SNP	G	T	T			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chrX:133527567G>T	uc004exj.2	+	4	479	c.277G>T	c.(277-279)GGT>TGT	p.G93C	PHF6_uc004exk.2_Missense_Mutation_p.G93C|PHF6_uc011mvk.1_Missense_Mutation_p.G59C|PHF6_uc004exh.2_Missense_Mutation_p.G93C|PHF6_uc010nrr.2_Missense_Mutation_p.G93C|PHF6_uc004exi.2_Missense_Mutation_p.G93C	NM_001015877	NP_001015877	Q8IWS0	PHF6_HUMAN	PHD finger protein 6 isoform 1	93	PHD-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AGCAACAATTGGTTGTGATGT	0.368000													15	167	---	---	---	---	6.72482e-11	1.29117e-10	0.024245	1	0
Unknown	0	broad.mit.edu	37	1	20200621	20200623	+	IGR	DEL	CAC	-	-	rs144954291		TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr1:20200621_20200623delCAC								RNF186 (58850 upstream) : OTUD3 (8265 downstream)																							ccaccaccatcaccaccaccacc	0.202													3	6	---	---	---	---					
APOA4	337	broad.mit.edu	37	11	116693873	116693873	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr11:116693873delA	uc001pps.1	-	1	139	c.35delT	c.(34-36)CTGfs	p.L12fs		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		GACAGCCACCAGGGCCAGGGT	0.592													107	140	---	---	---	---					
Unknown	0	broad.mit.edu	37	12	7338794	7338794	+	IGR	DEL	G	-	-	rs113717305		TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr12:7338794delG								CLSTN3 (27266 upstream) : PEX5 (2965 downstream)																							cctgttgagaggggggactga	0.000													3	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	14	90203668	90203668	+	IGR	DEL	C	-	-	rs12897726		TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr14:90203668delC								FOXN3 (118174 upstream) : C14orf143 (59803 downstream)																							CTCTTTCTTTCtttttttttt	0.189													5	8	---	---	---	---					
Unknown	0	broad.mit.edu	37	15	22013074	22013075	+	IGR	INS	-	C	C	rs146327079		TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr15:22013074_22013075insC								LOC646214 (72335 upstream) : CXADRP2 (1345 downstream)																							AGAGGACCCAGCCCCTCGCATC	0.634													11	71	---	---	---	---					
Unknown	0	broad.mit.edu	37	15	31128274	31128275	+	IGR	INS	-	T	T	rs34976531		TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr15:31128274_31128275insT								ARHGAP11B (150465 upstream) : MTMR15 (67780 downstream)																							TTTTGATAAGCTTTTTTTTTTT	0.312													4	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	16	64770704	64770705	+	IGR	INS	-	CCAGTGATGGTCACCT	CCAGTGATGGTCACCT	rs140029302	by1000genomes	TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr16:64770704_64770705insCCAGTGATGGTCACCT								None (None upstream) : CDH11 (209980 downstream)																							TGTCACCACTGCCACCTTGTTC	0.371													3	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	19	14997642	14997642	+	IGR	DEL	A	-	-	rs34351275		TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr19:14997642delA								OR7A17 (5475 upstream) : OR7C2 (54659 downstream)																							ccatctcactaaaaaaaaaaa	0.184													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	2	92068309	92068310	+	IGR	INS	-	A	A			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr2:92068309_92068310insA								GGT8P (98156 upstream) : FKSG73 (60849 downstream)																							AAATACTATGGAAAAAATTTGT	0.292													8	24	---	---	---	---					
PRRT1	80863	broad.mit.edu	37	6	32119729	32119729	+	5'Flank	DEL	G	-	-	rs9281658		TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr6:32119729delG	uc003nzt.2	-						PRRT1_uc003nzs.2_5'Flank|PRRT1_uc003nzu.2_Intron|PPT2_uc003nzw.2_5'Flank|PPT2_uc003nzx.2_5'Flank|PPT2_uc011dpi.1_5'Flank|PPT2_uc003nzy.1_5'Flank|PPT2_uc003nzz.2_5'Flank|PPT2_uc003oaa.2_5'Flank|PPT2_uc010jtu.1_5'Flank	NM_030651	NP_085154	Q99946	PRRT1_HUMAN	NG5 protein						response to biotic stimulus	integral to membrane				breast(1)	1						AGGCAGCGGCggggggggggg	0.502													3	5	---	---	---	---					
HLA-DRB5	3127	broad.mit.edu	37	6	32557588	32557589	+	5'Flank	INS	-	T	T	rs35683586		TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr6:32557588_32557589insT	uc003obk.3	-						HLA-DRB1_uc003obp.3_5'Flank	NM_002125	NP_002116	Q30154	DRB5_HUMAN	major histocompatibility complex, class II, DR						antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						ACTATGAACCCCTCCACCCACA	0.520													4	5	---	---	---	---					
SLC22A2	6582	broad.mit.edu	37	6	160664756	160664757	+	Frame_Shift_Del	DEL	AT	-	-			TCGA-FE-A235-01A-11D-A16O-08	TCGA-FE-A235-10A-01D-A16O-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe317172-c1fd-4d34-a694-ef2be40ff0e4	93ec843a-30ab-4881-ac2a-7bfcd79d5e67	g.chr6:160664756_160664757delAT	uc003qtf.2	-	7	1296_1297	c.1126_1127delAT	c.(1126-1128)ATCfs	p.I376fs	SLC22A2_uc003qte.1_Frame_Shift_Del_p.I376fs	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	376	Helical; (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		ATCCAGGTAGATATTGTCACCT	0.535													41	56	---	---	---	---					
