Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
MTOR	2475	broad.mit.edu	37	1	11187151	11187151	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:11187151C>T	uc001asd.2	-	45	6388	c.6267G>A	c.(6265-6267)ATG>ATA	p.M2089I	MTOR_uc001asc.2_Missense_Mutation_p.M294I	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	2089					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TCCCTGATTTCATGTACTTCC	0.488000													8	38					0	0	0	0
PTPRU	10076	broad.mit.edu	37	1	29602008	29602008	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:29602008G>A	uc001bru.2	+	8	1303	c.1193G>A	c.(1192-1194)CGT>CAT	p.R398H	PTPRU_uc001brv.2_Missense_Mutation_p.R398H|PTPRU_uc001brw.2_Missense_Mutation_p.R398H|PTPRU_uc009vtq.2_Missense_Mutation_p.R398H|PTPRU_uc009vtr.2_Missense_Mutation_p.R398H	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	398	Fibronectin type-III 2.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		ATCCAGGCCCGTCAGCTGACC	0.483000													21	18					0	0	0	0
CSMD2	114784	broad.mit.edu	37	1	34049245	34049245	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:34049245C>G	uc001bxn.1	-	48	7272	c.7243G>C	c.(7243-7245)GAT>CAT	p.D2415H	CSMD2_uc001bxm.1_Missense_Mutation_p.D2413H	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2415	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GACTTACCATCAAAAATCTCA	0.328000													20	98					0	0	0	0
EBNA1BP2	10969	broad.mit.edu	37	1	43630162	43630162	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:43630162C>T	uc001cin.2	-	9	1070	c.873G>A	c.(871-873)AAG>AAA	p.K291K	EBNA1BP2_uc001cio.2_Silent_p.K346K|EBNA1BP2_uc001cim.2_Silent_p.K186K|EBNA1BP2_uc010ojx.1_Silent_p.K346K	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	291					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTCCAGGTCTCTTCTACAGAA	0.448000													12	66					0	0	0	0
CYP4B1	1580	broad.mit.edu	37	1	47278285	47278285	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:47278285G>A	uc001cqm.3	+	4	569	c.485G>A	c.(484-486)CGT>CAT	p.R162H	CYP4B1_uc009vyl.1_5'UTR|CYP4B1_uc001cqn.3_Missense_Mutation_p.R162H|CYP4B1_uc009vym.2_Missense_Mutation_p.R147H|CYP4B1_uc010omk.1_5'UTR|CYP4B1_uc010oml.1_5'UTR	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	162					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					GAGTCTACACGTATCATGCTG	0.572000													20	46					0	0	0	0
GBP2	2634	broad.mit.edu	37	1	89579771	89579771	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:89579771C>T	uc001dmz.1	-	7	1348	c.1077G>A	c.(1075-1077)GAG>GAA	p.E359E	GBP2_uc001dmy.1_RNA	NM_004120	NP_004111	P32456	GBP2_HUMAN	guanylate binding protein 2,	359					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)	1		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		TGGCCTCTCTCTCACTGTCCC	0.502000													23	97					0	0	0	0
SPAG17	200162	broad.mit.edu	37	1	118583431	118583431	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:118583431G>C	uc001ehk.2	-	22	3156	c.3088C>G	c.(3088-3090)CAA>GAA	p.Q1030E		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1030						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CCTGAGATTTGAGTGGGTATA	0.363000													8	44					0	0	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145015938	145015938	+	Silent	SNP	C	T	T	rs144857876	byFrequency	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:145015938C>T	uc001elx.3	-	3	485	c.150G>A	c.(148-150)CCG>CCA	p.P50P	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elm.3_5'UTR|PDE4DIP_uc001eln.3_Silent_p.P50P|PDE4DIP_uc001elo.2_Silent_p.P121P|PDE4DIP_uc001emh.2_Silent_p.P121P|uc001emj.2_Intron	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:Variant_position_missing_in_Q5VU43_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTGCACAAACGGGACCTTTT	0.443000			T	PDGFRB	MPD								29	492					0	0	0	0
TCHH	7062	broad.mit.edu	37	1	152083791	152083791	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:152083791C>T	uc001ezp.2	-	2	1902	c.1902G>A	c.(1900-1902)CTG>CTA	p.L634L	TCHH_uc009wne.1_Silent_p.L634L	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	634	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCGCTCTTCAGCAGCTGCT	0.672000													22	46					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152277136	152277136	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:152277136C>T	uc001ezu.1	-	3	10262	c.10226G>A	c.(10225-10227)CGA>CAA	p.R3409Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3409	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTTGTCTTCGTCCAGTGCT	0.602000									Ichthyosis				53	169					0	0	0	0
SMG5	23381	broad.mit.edu	37	1	156233278	156233278	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:156233278G>A	uc001foc.3	-	13	2088	c.1939C>T	c.(1939-1941)CAG>TAG	p.Q647*	SMG5_uc009wrv.2_Nonsense_Mutation_p.Q132*	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	647					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					ATCAGGACCTGAAGCTTCTCC	0.602000													11	97					0	0	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161024455	161024455	+	Missense_Mutation	SNP	T	C	C	rs146389701	byFrequency	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:161024455T>C	uc001fxl.2	-	4	732	c.386A>G	c.(385-387)AAG>AGG	p.K129R	ARHGAP30_uc001fxk.2_Missense_Mutation_p.K129R|ARHGAP30_uc001fxm.2_5'UTR|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_5'UTR	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	129	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CTCTAGGATCTTGACCAAGCG	0.527000													15	60					0	0	0	0
NOS1AP	9722	broad.mit.edu	37	1	162326887	162326887	+	Silent	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:162326887C>G	uc001gbv.2	+	8	1287	c.900C>G	c.(898-900)CTC>CTG	p.L300L	NOS1AP_uc010pkr.1_Silent_p.L295L|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Silent_p.L295L	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	300					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			agcagctcctccagcagcAGC	0.517000													13	45					0	0	0	0
ABL2	27	broad.mit.edu	37	1	179084052	179084052	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:179084052C>T	uc001gmj.3	-	9	1809	c.1522G>A	c.(1522-1524)GAG>AAG	p.E508K	ABL2_uc010pnf.1_Missense_Mutation_p.E508K|ABL2_uc010png.1_Missense_Mutation_p.E487K|ABL2_uc010pnh.1_Missense_Mutation_p.E487K|ABL2_uc009wxe.2_Missense_Mutation_p.E487K|ABL2_uc001gmg.3_Missense_Mutation_p.E493K|ABL2_uc001gmi.3_Missense_Mutation_p.E493K|ABL2_uc001gmh.3_Missense_Mutation_p.E472K|ABL2_uc010pne.1_Missense_Mutation_p.E472K	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	508	Protein kinase.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.H508L(1)		lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GGGCATCCCTCAGGCTGTTCC	0.403000			T	ETV6	AML								22	72					0	0	0	0
PRG4	10216	broad.mit.edu	37	1	186276052	186276052	+	Missense_Mutation	SNP	A	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:186276052A>C	uc001gru.3	+	7	1252	c.1201A>C	c.(1201-1203)ACC>CCC	p.T401P	PRG4_uc001grt.3_Missense_Mutation_p.T360P|PRG4_uc009wyl.2_Missense_Mutation_p.T308P|PRG4_uc009wym.2_Missense_Mutation_p.T267P|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	401	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|7.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ACCCACCACCACCAAGGAGCC	0.642000													6	55					0	0	0	0
TMEM183A	92703	broad.mit.edu	37	1	202992016	202992016	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:202992016C>T	uc001gyu.1	+	8	1037	c.979C>T	c.(979-981)CAT>TAT	p.H327Y	TMEM183A_uc001gyv.1_RNA|TMEM183A_uc001gyw.1_Missense_Mutation_p.H326Y|TMEM183A_uc001gyx.1_Missense_Mutation_p.S323L|TMEM183A_uc001gyy.2_5'Flank	NM_001079809	NP_001073277	Q8IXX5	T183A_HUMAN	transmembrane protein 183B	327						integral to membrane					0			BRCA - Breast invasive adenocarcinoma(75;0.18)			CATGCGGCATCATCGAGTGAG	0.488000													31	114					0	0	0	0
AVPR1B	553	broad.mit.edu	37	1	206224835	206224835	+	Missense_Mutation	SNP	G	A	A	rs41314448		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:206224835G>A	uc001hds.2	+	1	553	c.395G>A	c.(394-396)CGC>CAC	p.R132H		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	132	Cytoplasmic (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	ACGCTGGACCGCTACCTGGCT	0.657000													15	62					0	0	0	0
PLXNA2	5362	broad.mit.edu	37	1	208218548	208218548	+	Missense_Mutation	SNP	T	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:208218548T>G	uc001hgz.2	-	19	4261	c.3503A>C	c.(3502-3504)AAC>ACC	p.N1168T		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1168	IPT/TIG 4.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		AGGGCAGAGGTTTTTGCCCTG	0.388000													4	54					0	0	0	0
Unknown	0	broad.mit.edu	37	1	211380654	211380654	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:211380654G>A	uc001hid.2	+	1	266	c.74G>A	c.(73-75)CGG>CAG	p.R25Q						SubName: Full=Px19-like protein, isoform CRA_c; SubName: Full=cDNA, FLJ92457, Homo sapiens px19-like protein (PX19), mRNA;																		TTCTGGCAGCGGTACCCGAAT	0.607000													3	11					0	0	0	0
PTPN14	5784	broad.mit.edu	37	1	214556663	214556663	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:214556663C>T	uc001hkk.1	-	13	2806	c.2535G>A	c.(2533-2535)ATG>ATA	p.M845I	PTPN14_uc010pty.1_Missense_Mutation_p.M746I	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	845					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CCCTGATCATCATCTCTCTCT	0.512000													18	61					0	0	0	0
WDR64	128025	broad.mit.edu	37	1	241850813	241850813	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:241850813C>T	uc001hze.1	+	7	1067	c.860C>T	c.(859-861)TCA>TTA	p.S287L	WDR64_uc001hzf.1_Missense_Mutation_p.S7L			B1ANS9	WDR64_HUMAN	RecName: Full=WD repeat-containing protein 64;	287										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			AGATATATTTCAGCCCTAAAT	0.343000													20	83					0	0	0	0
ZNF496	84838	broad.mit.edu	37	1	247492661	247492661	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:247492661C>T	uc001ico.2	-	3	685	c.220G>A	c.(220-222)GAG>AAG	p.E74K	ZNF496_uc009xgv.2_Missense_Mutation_p.E74K|ZNF496_uc001icp.2_Missense_Mutation_p.E74K|ZNF496_uc010pyv.1_Missense_Mutation_p.E74K	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	74	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			GTGTGCCTCTCAGGCCGCAGC	0.711000													8	29					0	0	0	0
ZMYND11	10771	broad.mit.edu	37	10	267290	267290	+	Silent	SNP	T	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:267290T>C	uc010pzt.1	+	4	860	c.432T>C	c.(430-432)GTT>GTC	p.V144V	ZMYND11_uc001ifk.2_Silent_p.V144V|ZMYND11_uc010pzu.1_Silent_p.V144V|ZMYND11_uc010pzv.1_Intron|ZMYND11_uc010pzw.1_Intron|ZMYND11_uc001ifm.2_Intron|ZMYND11_uc010pzx.1_Silent_p.V144V|ZMYND11_uc001ifn.2_Intron|ZMYND11_uc009xhg.2_Silent_p.V127V|ZMYND11_uc009xhh.2_Intron|ZMYND11_uc010pzy.1_Intron	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	104	PHD-type.				cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		AGTGCCCAGTTTGCAGGGTGA	0.453000													14	78					0	0	0	0
C10orf18	54906	broad.mit.edu	37	10	5781788	5781788	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:5781788C>T	uc001iij.2	+	13	2280	c.1655C>T	c.(1654-1656)TCT>TTT	p.S552F	C10orf18_uc001iik.2_Intron	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	552										ovary(1)|central_nervous_system(1)	2						ACACCAGTATCTGAGGCTAGA	0.403000													29	78					0	0	0	0
PHYH	5264	broad.mit.edu	37	10	13323083	13323083	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:13323083C>T	uc001imf.2	-	8	944	c.856G>A	c.(856-858)GAT>AAT	p.D286N	PHYH_uc001ime.2_Missense_Mutation_p.D186N|PHYH_uc001img.2_Missense_Mutation_p.D269N	NM_006214	NP_006205	O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase isoform a precursor	286					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding				0		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	TAGTGGCAATCGGCACTGGCG	0.433000													15	58					0	0	0	0
FZD8	8325	broad.mit.edu	37	10	35928655	35928655	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:35928655G>A	uc001iyz.1	-	1	1708	c.1703C>T	c.(1702-1704)CCG>CTG	p.P568L		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	568	Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						CCGCAGGCACGGGCAGTTGTG	0.672000													12	35					0	0	0	0
BTAF1	9044	broad.mit.edu	37	10	93719794	93719794	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:93719794G>C	uc001khr.2	+	11	1244	c.1146G>C	c.(1144-1146)ATG>ATC	p.M382I	BTAF1_uc001khs.1_Missense_Mutation_p.M52I	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	382					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TAAAACACATGAACGAAACAG	0.383000													29	87					0	0	0	0
PLCE1	51196	broad.mit.edu	37	10	95791053	95791053	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:95791053G>C	uc001kjk.2	+	2	884	c.250G>C	c.(250-252)GAG>CAG	p.E84Q	PLCE1_uc010qnx.1_Missense_Mutation_p.E84Q	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	84					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				AGTGAGTGATGAGAACAGTAA	0.383000													25	58					0	0	0	0
LOC729020	729020	broad.mit.edu	37	10	105005975	105005975	+	Silent	SNP	C	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:105005975C>A	uc009xxi.2	+	1	332	c.222C>A	c.(220-222)TCC>TCA	p.S74S	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	74					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						TGATGGTGTCCAAGCCAGAAC	0.488000													8	113					7.93312e-07	8.322e-07	1	0
COL17A1	1308	broad.mit.edu	37	10	105796297	105796297	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:105796297G>C	uc001kxr.2	-	48	3540	c.3371C>G	c.(3370-3372)TCT>TGT	p.S1124C		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1124	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		ATAGTCCAAAGACAGGAGGGA	0.592000													7	25					0	0	0	0
EMX2	2018	broad.mit.edu	37	10	119303110	119303110	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:119303110C>T	uc001ldh.3	+	1	1155	c.332C>T	c.(331-333)TCG>TTG	p.S111L	EMX2OS_uc001ldf.2_5'Flank|EMX2OS_uc001ldg.2_Intron|EMX2_uc001ldi.3_Missense_Mutation_p.S111L	NM_004098	NP_004089	Q04743	EMX2_HUMAN	empty spiracles homeobox 2 isoform 1	111						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		CTATTCGCCTCGCAGCAGCGG	0.697000													17	46					0	0	0	0
NLRP6	171389	broad.mit.edu	37	11	280967	280967	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:280967G>A	uc010qvs.1	+	4	1233	c.1233G>A	c.(1231-1233)ACG>ACA	p.T411T	NLRP6_uc010qvt.1_Silent_p.T411T	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	411	NACHT.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		TGTCGCGCACGTCCAAGACCA	0.652000													43	134					0	0	0	0
OR51M1	390059	broad.mit.edu	37	11	5411115	5411115	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:5411115C>T	uc010qzc.1	+	1	487	c.487C>T	c.(487-489)CGG>TGG	p.R163W	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	163						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTCATCTTCCGGGGACCTGT	0.542000													42	180					0	0	0	0
ST5	6764	broad.mit.edu	37	11	8751512	8751512	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:8751512C>T	uc001mgt.2	-	3	1511	c.1325G>A	c.(1324-1326)CGC>CAC	p.R442H	ST5_uc009yfr.2_Intron|ST5_uc001mgu.2_Intron|ST5_uc001mgv.2_Missense_Mutation_p.R442H|ST5_uc010rbq.1_Intron|ST5_uc001mgw.1_Missense_Mutation_p.R442H	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	442	Interaction with ABL1.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CTGGGACTTGCGGTGACCACG	0.577000													6	409					0	0	0	0
USP47	55031	broad.mit.edu	37	11	11964241	11964241	+	Silent	SNP	T	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:11964241T>C	uc001mjq.1	+	21	3496	c.2733T>C	c.(2731-2733)CCT>CCC	p.P911P	USP47_uc001mjr.2_Silent_p.P823P|USP47_uc001mjs.2_Silent_p.P891P|USP47_uc001mjt.1_Silent_p.P197P	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	911				P -> S (in Ref. 1; BAG54467).	base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TCGAATCACCTCTCAATGAGA	0.413000													4	57					0	0	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18633881	18633881	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:18633881G>A	uc001moy.2	-	4	2082	c.1866C>T	c.(1864-1866)ATC>ATT	p.I622I	SPTY2D1_uc010rdi.1_Silent_p.I622I	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	622										breast(1)	1						CATAACCAAAGATTTCTCTAA	0.323000													16	64					0	0	0	0
ZNF408	79797	broad.mit.edu	37	11	46726882	46726882	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:46726882C>G	uc001nde.1	+	5	1862	c.1632C>G	c.(1630-1632)ATC>ATG	p.I544M	ZNF408_uc010rgw.1_Missense_Mutation_p.I536M	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	544	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						GCCATCTCATCTCACACACCG	0.677000													10	24					0	0	0	0
OR4C11	219429	broad.mit.edu	37	11	55371308	55371308	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:55371308G>A	uc010rii.1	-	1	542	c.542C>T	c.(541-543)CCC>CTC	p.P181L		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTTCAACAAGGGCTGCAAATC	0.403000													16	14					0	0	0	0
OR5R1	219479	broad.mit.edu	37	11	56185150	56185150	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:56185150G>C	uc010rji.1	-	1	559	c.559C>G	c.(559-561)CTG>GTG	p.L187V		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAGCAGGACAGAGCTAAGAAG	0.448000													15	54					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62289230	62289230	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:62289230G>C	uc001ntl.2	-	5	12959	c.12659C>G	c.(12658-12660)TCA>TGA	p.S4220*	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4220					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTTGGGTCCTGAGACGTCAAG	0.483000													72	245					0	0	0	0
FERMT3	83706	broad.mit.edu	37	11	63990638	63990638	+	Missense_Mutation	SNP	A	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:63990638A>T	uc001nyl.2	+	14	1950	c.1801A>T	c.(1801-1803)AAT>TAT	p.N601Y	FERMT3_uc001nym.2_Missense_Mutation_p.N597Y	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	601					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						GCGCCAGTGGAATGTCAACTG	0.637000													24	70					0	0	0	0
PYGM	5837	broad.mit.edu	37	11	64521495	64521495	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:64521495C>T	uc001oax.3	-	10	1912	c.1095G>A	c.(1093-1095)GCG>GCA	p.A365A	PYGM_uc001oay.3_Silent_p.A277A	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	365					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	TCACATCCCACGCCTGGCACA	0.672000													4	11					0	0	0	0
MALAT1	378938	broad.mit.edu	37	11	65270662	65270662	+	RNA	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:65270662G>C	uc010roh.1	+	1		c.5430G>C			uc001ody.2_RNA|MALAT1_uc001odz.2_RNA	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						GCTGTTAACAGATAAGTTTAA	0.408000													5	12					0	0	0	0
PC	5091	broad.mit.edu	37	11	66617476	66617476	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:66617476C>T	uc001ojn.1	-	18	2879	c.2830G>A	c.(2830-2832)GTG>ATG	p.V944M	PC_uc001ojo.1_Missense_Mutation_p.V944M|PC_uc001ojp.1_Missense_Mutation_p.V944M|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	944					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	AACTCCACCACGGAGCGGGGA	0.627000													9	70					0	0	0	0
SHANK2	22941	broad.mit.edu	37	11	70331881	70331881	+	Missense_Mutation	SNP	G	A	A	rs146717159		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:70331881G>A	uc001oqc.2	-	21	4595	c.4517C>T	c.(4516-4518)ACG>ATG	p.T1506M	SHANK2_uc010rqn.1_Missense_Mutation_p.T918M|SHANK2_uc001opz.2_Missense_Mutation_p.T911M|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1127					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			AGTGCTGGTCGTCTCGAGGTG	0.587000													27	51					0	0	0	0
OR2AT4	341152	broad.mit.edu	37	11	74799942	74799942	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:74799942G>A	uc010rro.1	-	1	817	c.817C>T	c.(817-819)CTT>TTT	p.L273F		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	273	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGGAAGTCAAGGGGCAGGTCA	0.522000													19	62					0	0	0	0
DGAT2	84649	broad.mit.edu	37	11	75508295	75508295	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:75508295G>C	uc001oxa.2	+	6	986	c.727G>C	c.(727-729)GAG>CAG	p.E243Q	DGAT2_uc001oxb.2_Missense_Mutation_p.E200Q	NM_032564	NP_115953	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	243	Cytoplasmic (Potential).				glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity				0	Ovarian(111;0.103)					GGGTGCGGCTGAGTCTCTGAG	0.572000													24	68					0	0	0	0
PICALM	8301	broad.mit.edu	37	11	85779727	85779727	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:85779727G>A	uc001pbm.2	-	1	382	c.96C>T	c.(94-96)CAC>CAT	p.H32H	PICALM_uc001pbl.2_Silent_p.H32H|PICALM_uc001pbn.2_Silent_p.H32H|PICALM_uc010rtl.1_Intron	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly	32	ENTH.				clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				CCATGATCTCGTGGGTCGTGG	0.468000			T	MLLT10|MLL	TALL|AML|								3	22					0	0	0	0
TMEM135	65084	broad.mit.edu	37	11	86868385	86868385	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:86868385C>T	uc001pch.2	+	5	422	c.399C>T	c.(397-399)GCC>GCT	p.A133A	TMEM135_uc010rtt.1_5'UTR|TMEM135_uc001pci.2_Intron|TMEM135_uc001pcg.1_Intron	NM_022918	NP_075069	Q86UB9	TM135_HUMAN	transmembrane protein 135	133						integral to membrane					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ATTTACAGGCCACAGAAACAC	0.303000													15	57					0	0	0	0
UBTFL1	642623	broad.mit.edu	37	11	89819202	89819202	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:89819202G>A	uc010rub.1	+	1	85	c.85G>A	c.(85-87)GAT>AAT	p.D29N		NM_001143975	NP_001137447	P0CB47	UBFL1_HUMAN	upstream binding transcription factor, RNA	29					multicellular organismal development	cytoplasm|nucleus	DNA binding				0						TCGCCCATCTGATGACAACAG	0.428000													31	101					0	0	0	0
TAGLN	6876	broad.mit.edu	37	11	117075058	117075058	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:117075058C>T	uc001pqm.2	+	5	710	c.589C>T	c.(589-591)CGG>TGG	p.R197W	uc001pqk.1_5'Flank|TAGLN_uc001pql.1_Intron|TAGLN_uc001pqn.2_Missense_Mutation_p.R197W|TAGLN_uc001pqo.2_Missense_Mutation_p.R197W|TAGLN_uc001pqp.2_Missense_Mutation_p.R197W|uc001pqq.1_5'Flank	NM_003186	NP_003177	Q01995	TAGL_HUMAN	transgelin	197	Calponin-like.				muscle organ development	cytoplasm	actin binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|Epithelial(105;5.49e-05)|all cancers(92;0.000435)		CGGACGACCTCGGCAGATCAT	0.647000													16	49					0	0	0	0
IL10RA	3587	broad.mit.edu	37	11	117869847	117869847	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:117869847G>A	uc001prv.2	+	7	1305	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	IL10RA_uc010rxl.1_Missense_Mutation_p.E390K|IL10RA_uc010rxm.1_Missense_Mutation_p.E390K|IL10RA_uc010rxn.1_Missense_Mutation_p.E261K|IL10RA_uc001prw.2_Missense_Mutation_p.E261K	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	410	Cytoplasmic (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		TCAAAACTCTGAGGGCCGGGC	0.652000													10	41					0	0	0	0
MCAM	4162	broad.mit.edu	37	11	119181849	119181849	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:119181849G>A	uc001pwf.2	-	13	1625	c.1596C>T	c.(1594-1596)CTC>CTT	p.L532L	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	532	Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		TGGAAGTGCTGAGGCCAGTGG	0.577000													26	145					0	0	0	0
CDON	50937	broad.mit.edu	37	11	125891182	125891182	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:125891182C>T	uc009zbw.2	-	3	438	c.310G>A	c.(310-312)GGT>AGT	p.G104S	CDON_uc001qdc.3_Missense_Mutation_p.G104S|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.G104S	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	104	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		ACAATGGCACCGATGCTATTG	0.433000													5	31					0	0	0	0
PRDM10	56980	broad.mit.edu	37	11	129772280	129772280	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:129772280C>T	uc001qfm.2	-	22	3643	c.3411G>A	c.(3409-3411)CAG>CAA	p.Q1137Q	PRDM10_uc001qfj.2_Silent_p.Q1038Q|PRDM10_uc001qfk.2_Silent_p.Q1000Q|PRDM10_uc001qfl.2_Silent_p.Q1051Q|PRDM10_uc010sbx.1_Silent_p.Q1047Q|PRDM10_uc001qfn.2_Silent_p.Q1133Q	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	1124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		ACTGTGTGGTCTGCTGTTGGC	0.547000													37	100					0	0	0	0
APLP2	334	broad.mit.edu	37	11	129999970	129999970	+	Missense_Mutation	SNP	G	A	A	rs140505383	byFrequency	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:129999970G>A	uc010sby.1	+	11	1650	c.1493G>A	c.(1492-1494)CGT>CAT	p.R498H	APLP2_uc001qfp.2_Missense_Mutation_p.R498H|APLP2_uc001qfq.2_Missense_Mutation_p.R442H|APLP2_uc010sbz.1_Missense_Mutation_p.R286H|APLP2_uc001qfr.2_Missense_Mutation_p.R264H|APLP2_uc001qfs.2_Missense_Mutation_p.R269H|APLP2_uc001qfv.2_Missense_Mutation_p.R389H	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	498	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		CGTTATGTCCGTGCTGAGAAC	0.468000													4	124					0	0	0	0
CD163	9332	broad.mit.edu	37	12	7639395	7639395	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:7639395G>A	uc001qsz.3	-	10	2286	c.2158C>T	c.(2158-2160)CGC>TGC	p.R720C	CD163_uc001qta.3_Missense_Mutation_p.R720C|CD163_uc009zfw.2_Missense_Mutation_p.R753C	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	720	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TTTACCAGGCGAAGTTGACCA	0.448000													20	67					0	0	0	0
LDHB	3945	broad.mit.edu	37	12	21794926	21794926	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:21794926G>A	uc001rfc.2	-	4	573	c.555C>T	c.(553-555)AGC>AGT	p.S185S	LDHB_uc001rfd.2_Silent_p.S185S|LDHB_uc001rfe.2_Silent_p.S185S	NM_002300	NP_002291	P07195	LDHB_HUMAN	L-lactate dehydrogenase B	185					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity			breast(2)|ovary(1)	3					NADH(DB00157)	ATCCATGGCAGCTGCTGGGAT	0.408000													13	56					0	0	0	0
ABCD2	225	broad.mit.edu	37	12	40013386	40013386	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:40013386C>G	uc001rmb.2	-	1	458	c.32G>C	c.(31-33)CGA>CCA	p.R11P		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	11	Interaction with PEX19.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						CCATTTCACTCGATCAGCTGC	0.473000													4	39					0	0	0	0
CNTN1	1272	broad.mit.edu	37	12	41374736	41374736	+	Silent	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:41374736G>C	uc001rmm.1	+	16	1943	c.1830G>C	c.(1828-1830)CTG>CTC	p.L610L	CNTN1_uc001rmn.1_Silent_p.L599L	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	610	Fibronectin type-III 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CAGGTGGTCTGAGAATAGAAG	0.413000													30	130					0	0	0	0
RACGAP1	29127	broad.mit.edu	37	12	50392997	50392997	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:50392997C>G	uc001rvt.2	-	11	1116	c.806G>C	c.(805-807)AGA>ACA	p.R269T	RACGAP1_uc009zlm.1_Missense_Mutation_p.R269T|RACGAP1_uc001rvs.2_Missense_Mutation_p.R269T|RACGAP1_uc001rvu.2_Missense_Mutation_p.R269T	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	269	Interaction with SLC26A8.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						TGTCTCAGTTCTTGGCTCCAG	0.443000													10	36					0	0	0	0
KRT2	3849	broad.mit.edu	37	12	53040579	53040579	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:53040579C>G	uc001sat.2	-	7	1447	c.1414G>C	c.(1414-1416)GCC>CCC	p.A472P		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	472	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		ACATCTAGGGCCAGCTTCACG	0.622000													21	68					0	0	0	0
ESPL1	9700	broad.mit.edu	37	12	53664560	53664560	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:53664560G>A	uc001sck.2	+	5	1438	c.1347G>A	c.(1345-1347)CTG>CTA	p.L449L	ESPL1_uc001scj.2_Silent_p.L124L	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	449					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GCCAAGAGCTGACGGACCACA	0.547000													20	61					0	0	0	0
MBD6	114785	broad.mit.edu	37	12	57919424	57919424	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:57919424C>A	uc001soj.1	+	6	897	c.673C>A	c.(673-675)CCC>ACC	p.P225T	MBD6_uc001sok.1_Missense_Mutation_p.P92T|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	225	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCTCAATGCTCCCTCATACAA	0.652000													40	163					2.66277e-13	2.86828e-13	1	0
USP15	9958	broad.mit.edu	37	12	62708688	62708688	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:62708688G>A	uc001src.1	+	4	475	c.466G>A	c.(466-468)GAC>AAC	p.D156N	USP15_uc001srb.1_Missense_Mutation_p.D156N|USP15_uc001sra.2_Missense_Mutation_p.D156N	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	156					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TAGCAAAGCTGACACAATAGG	0.308000													34	137					0	0	0	0
MYBPC1	4604	broad.mit.edu	37	12	102025384	102025384	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:102025384G>A	uc001tii.2	+	5	352	c.250G>A	c.(250-252)GAA>AAA	p.E84K	MYBPC1_uc001tif.1_Missense_Mutation_p.E97K|MYBPC1_uc001tig.2_Missense_Mutation_p.E109K|MYBPC1_uc010svq.1_Missense_Mutation_p.E71K|MYBPC1_uc001tih.2_Missense_Mutation_p.E109K|MYBPC1_uc001tij.2_Missense_Mutation_p.E84K|MYBPC1_uc010svr.1_Missense_Mutation_p.E84K|MYBPC1_uc010svs.1_Missense_Mutation_p.E84K|MYBPC1_uc010svt.1_Missense_Mutation_p.E72K|MYBPC1_uc010svu.1_Missense_Mutation_p.E84K|MYBPC1_uc001tik.2_Missense_Mutation_p.E58K	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	84	Ig-like C2-type 1.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						AGTCAAGGCTGAAGATCTTCT	0.438000													15	79					0	0	0	0
C12orf51	283450	broad.mit.edu	37	12	112703016	112703016	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr12:112703016G>C	uc009zwc.2	-	9	1304	c.1286C>G	c.(1285-1287)TCT>TGT	p.S429C	C12orf51_uc010syk.1_Missense_Mutation_p.S252C|C12orf51_uc001tts.2_Missense_Mutation_p.S252C|C12orf51_uc001ttt.3_Missense_Mutation_p.S252C	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						ATCATCTTTAGAGACAGTTTG	0.313000													13	40					0	0	0	0
ZMYM2	7750	broad.mit.edu	37	13	20601408	20601408	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr13:20601408G>C	uc001umr.2	+	10	2099	c.1801G>C	c.(1801-1803)GAT>CAT	p.D601H	ZMYM2_uc001ums.2_Missense_Mutation_p.D601H|ZMYM2_uc001umt.2_Missense_Mutation_p.D601H|ZMYM2_uc010tco.1_RNA|ZMYM2_uc001umv.2_5'UTR|ZMYM2_uc001umw.2_Missense_Mutation_p.D54H	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	601					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CACAATGCCTGATGGAAAACT	0.358000													3	3					0	0	0	0
ATP8A2	51761	broad.mit.edu	37	13	26436529	26436529	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr13:26436529C>G	uc001uqk.2	+	33	3308	c.3166C>G	c.(3166-3168)CCA>GCA	p.P1056A	ATP8A2_uc010tdi.1_Missense_Mutation_p.P991A|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.P606A	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	1016	Extracellular (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TCCCATTGCTCCAGATATGAG	0.532000													7	40					0	0	0	0
STARD13	90627	broad.mit.edu	37	13	33701584	33701584	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr13:33701584G>A	uc001uuw.2	-	6	1974	c.1848C>T	c.(1846-1848)CTC>CTT	p.L616L	STARD13_uc001uuu.2_Silent_p.L608L|STARD13_uc001uuv.2_Silent_p.L498L|STARD13_uc001uux.2_Silent_p.L581L|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Silent_p.L601L	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	616					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AGAAGCGCTGGAGCAGGCTCA	0.642000													5	15					0	0	0	0
GPC5	2262	broad.mit.edu	37	13	92101090	92101090	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr13:92101090C>T	uc010tif.1	+	2	605	c.239C>T	c.(238-240)GCG>GTG	p.A80V		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	80						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TATCAGATTGCGGCTCGCCAG	0.433000													17	50					0	0	0	0
Unknown	0	broad.mit.edu	37	14	19857019	19857019	+	RNA	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:19857019C>T	uc001vvq.1	-	5		c.511G>A								Homo sapiens cDNA FLJ12852 fis, clone NT2RP2003445.																		ATTATACTCTCAGCATCCTGG	0.383000													5	144					0	0	0	0
JUB	84962	broad.mit.edu	37	14	23451250	23451250	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:23451250G>A	uc001whz.2	-	1	602	c.226C>T	c.(226-228)CAG>TAG	p.Q76*		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	76	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		GAGCCGCGCTGATTTCGCTCA	0.687000													5	13					0	0	0	0
JUB	84962	broad.mit.edu	37	14	23451383	23451383	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:23451383G>A	uc001whz.2	-	1	469	c.93C>T	c.(91-93)CCC>CCT	p.P31P		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	31	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		TGCCCGGCCCGGGGGTCCCGT	0.677000													7	24					0	0	0	0
IRF9	10379	broad.mit.edu	37	14	24633337	24633337	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:24633337G>C	uc001wmq.2	+	6	770	c.643G>C	c.(643-645)GAG>CAG	p.E215Q	RNF31_uc001wmp.2_RNA|IRF9_uc010alj.2_Missense_Mutation_p.E113Q	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	215					interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)		GCTTCCTCCAGAGCCAGGTAC	0.522000													36	113					0	0	0	0
AKAP6	9472	broad.mit.edu	37	14	33291002	33291002	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:33291002C>T	uc001wrq.2	+	13	4153	c.3983C>T	c.(3982-3984)TCT>TTT	p.S1328F		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1328					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AGTAAAGACTCTTCATTTTCA	0.428000													3	58					0	0	0	0
SFRS5	6430	broad.mit.edu	37	14	70237755	70237755	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:70237755G>A	uc001xll.2	+	8	1935	c.484G>A	c.(484-486)GAA>AAA	p.E162K	SFRS5_uc001xlm.2_RNA|SFRS5_uc001xlo.2_Missense_Mutation_p.E162K|SFRS5_uc001xlp.2_Missense_Mutation_p.E162K|SFRS5_uc001xlq.2_Missense_Mutation_p.E159K	NM_006925	NP_008856	Q13243	SRSF5_HUMAN	splicing factor, arginine/serine-rich 5	162	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding				0				all cancers(60;0.00144)|BRCA - Breast invasive adenocarcinoma(234;0.0132)|OV - Ovarian serous cystadenocarcinoma(108;0.0154)		GAATGCTATTGAAAAACTTTC	0.328000													14	51					0	0	0	0
CKB	1152	broad.mit.edu	37	14	103986629	103986629	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:103986629G>A	uc001ynf.1	-	7	877	c.797C>T	c.(796-798)TCT>TTT	p.S266F	CKB_uc001yne.1_Missense_Mutation_p.S88F|CKB_uc010awr.1_Missense_Mutation_p.S197F	NM_001823	NP_001814	P12277	KCRB_HUMAN	brain creatine kinase	266	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity				0		Melanoma(154;0.155)	Epithelial(46;0.14)		Creatine(DB00148)	ATAGTCCTTAGACTTGAAGAG	0.567000													8	35					0	0	0	0
INF2	64423	broad.mit.edu	37	14	105174903	105174903	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:105174903G>A	uc001ypb.2	+	9	2009	c.1866G>A	c.(1864-1866)CGG>CGA	p.R622R	INF2_uc010tyi.1_Silent_p.R622R|INF2_uc001ypc.2_Silent_p.R622R|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	622	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		TGGCCCCCCGGGCCAGGAAGG	0.697000											OREG0022959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	28					0	0	0	0
TPM1	7168	broad.mit.edu	37	15	63336307	63336307	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr15:63336307G>C	uc002alg.2	+	2	387	c.196G>C	c.(196-198)GAT>CAT	p.D66H	TPM1_uc002alh.2_Missense_Mutation_p.D66H|TPM1_uc010bgn.2_RNA|TPM1_uc002ali.2_Missense_Mutation_p.D66H|TPM1_uc002alj.2_Intron|TPM1_uc002alk.2_Missense_Mutation_p.D66H|TPM1_uc002all.2_Intron|TPM1_uc002alm.2_Missense_Mutation_p.D108H|TPM1_uc010uie.1_Intron|TPM1_uc002alp.2_Missense_Mutation_p.D66H	NM_001018005	NP_001018005	P09493	TPM1_HUMAN	tropomyosin 1 alpha chain isoform 1	66	By similarity.				cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle				0						GGCTCTCAAAGATGCCCAGGA	0.567000													10	38					0	0	0	0
ADPGK	83440	broad.mit.edu	37	15	73048650	73048650	+	Missense_Mutation	SNP	G	C	C	rs142833607	by1000genomes	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr15:73048650G>C	uc002avg.3	-	5	876	c.782C>G	c.(781-783)TCT>TGT	p.S261C	ADPGK_uc002ave.3_5'UTR|ADPGK_uc010ukw.1_Missense_Mutation_p.S203C|ADPGK_uc002avf.3_Missense_Mutation_p.S261C|ADPGK_uc002avi.3_Missense_Mutation_p.S139C|ADPGK_uc002avh.3_Missense_Mutation_p.S22C	NM_031284	NP_112574	Q9BRR6	ADPGK_HUMAN	ADP-dependent glucokinase	261	ADPK.				glycolysis	extracellular region	ADP-specific glucokinase activity|metal ion binding				0						GTGCAATCCAGAGAGGACCAC	0.517000													14	67					0	0	0	0
MESDC1	59274	broad.mit.edu	37	15	81295306	81295306	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr15:81295306G>A	uc002bfz.2	+	1	2012	c.694G>A	c.(694-696)GTG>ATG	p.V232M		NM_022566	NP_072088	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	232											0						GCTGGCCTGCGTGCGCGAGGT	0.697000													4	16					0	0	0	0
HN1L	90861	broad.mit.edu	37	16	1741947	1741947	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:1741947C>T	uc002cmg.2	+	3	333	c.297C>T	c.(295-297)GTC>GTT	p.V99V	HN1L_uc010uvi.1_Silent_p.V127V|HN1L_uc010brt.2_RNA|HN1L_uc010bru.2_Intron|HN1L_uc010uvj.1_Intron|HN1L_uc010uvk.1_Silent_p.V86V	NM_144570	NP_653171	Q9H910	HN1L_HUMAN	hematological and neurological expressed 1-like	99						cytoplasm|nucleus				upper_aerodigestive_tract(1)	1						GGTCTCCGGTCACTGCCACTT	0.542000													15	46					0	0	0	0
CP110	9738	broad.mit.edu	37	16	19548342	19548342	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:19548342G>A	uc002dgl.3	+	4	1598	c.1351G>A	c.(1351-1353)GAA>AAA	p.E451K	CP110_uc002dgk.3_Missense_Mutation_p.E451K			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	451	Interaction with CEP76.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						TGAAGTCAAAGAAGATGTGGT	0.358000													13	70					0	0	0	0
DNAH3	55567	broad.mit.edu	37	16	21011751	21011751	+	Silent	SNP	G	A	A	rs138378920		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:21011751G>A	uc010vbe.1	-	43	6216	c.6216C>T	c.(6214-6216)TTC>TTT	p.F2072F		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2072	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TGGGACCCACGAACAGCATTG	0.493000													14	32					0	0	0	0
UBFD1	56061	broad.mit.edu	37	16	23570850	23570850	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:23570850G>A	uc002dlv.2	+	3	619	c.417G>A	c.(415-417)TTG>TTA	p.L139L	EARS2_uc002dls.3_5'Flank|EARS2_uc002dlt.3_5'Flank|EARS2_uc002dlu.2_5'Flank	NM_019116	NP_061989	O14562	UBFD1_HUMAN	ubiquitin-binding protein homolog	139	Ubiquitin-like.										0				GBM - Glioblastoma multiforme(48;0.0331)		ATAAAACATTGAGAGAAATAA	0.483000													5	27					0	0	0	0
NKD1	85407	broad.mit.edu	37	16	50667367	50667367	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:50667367G>C	uc002egg.1	+	10	1312	c.1088G>C	c.(1087-1089)AGA>ACA	p.R363T		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	363					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		CACGTGGCCAGAGGGGCAAGA	0.711000													8	30					0	0	0	0
CES3	23491	broad.mit.edu	37	16	67005131	67005131	+	Silent	SNP	G	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:67005131G>T	uc002eqt.2	+	10	1273	c.1200G>T	c.(1198-1200)TCG>TCT	p.S400S	CES3_uc010cdz.2_Silent_p.S400S|CES3_uc010cea.2_Intron|CES3_uc010viw.1_Silent_p.S39S	NM_024922	NP_079198	Q6UWW8	EST3_HUMAN	carboxylesterase 3 precursor	400						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			ovary(3)|central_nervous_system(2)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GAAGCAACTCGGACGCACAAG	0.537000													16	33					2.32078e-09	2.46679e-09	1	0
CTCF	10664	broad.mit.edu	37	16	67662366	67662366	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:67662366C>G	uc002etl.2	+	9	1902	c.1612C>G	c.(1612-1614)CTC>GTC	p.L538V	CTCF_uc010cek.2_Missense_Mutation_p.L210V|CTCF_uc002etm.1_Missense_Mutation_p.L27V	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	538	C2H2-type 10.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		GAAGCAGCTTCTCGACATGCA	0.547000													34	62					0	0	0	0
CTCF	10664	broad.mit.edu	37	16	67662427	67662427	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:67662427C>G	uc002etl.2	+	9	1963	c.1673C>G	c.(1672-1674)TCT>TGT	p.S558C	CTCF_uc010cek.2_Missense_Mutation_p.S230C|CTCF_uc002etm.1_Missense_Mutation_p.S47C	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	558	C2H2-type 11; atypical.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		TTTGTCTGTTCTAAGTGTGGG	0.483000													37	76					0	0	0	0
EDC4	23644	broad.mit.edu	37	16	67912724	67912724	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr16:67912724C>T	uc002eur.2	+	11	1435	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L	EDC4_uc010cer.2_Silent_p.L42L|EDC4_uc010vkg.1_Silent_p.L355L|EDC4_uc010ces.1_Silent_p.L266L|EDC4_uc002eus.2_Silent_p.L153L	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	423					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		ACCTGATTCTCAGCGATGTGC	0.567000													38	106					0	0	0	0
MYO15A	51168	broad.mit.edu	37	17	18045516	18045516	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:18045516C>T	uc010vxh.1	+	23	6111	c.5773C>T	c.(5773-5775)CTG>TTG	p.L1925L		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1925	Neck or regulatory domain.|IQ 2.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					ATTCCGCTCTCTGCGCCACAA	0.592000													8	24					0	0	0	0
SARM1	23098	broad.mit.edu	37	17	26715421	26715421	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:26715421G>A	uc010crl.1	+	10	1853	c.1786G>A	c.(1786-1788)GAG>AAG	p.E596K	SARM1_uc010waj.1_RNA|SARM1_uc002hbe.1_Missense_Mutation_p.E140K	NM_015077	NP_055892	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	596	TIR.				innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CATTGATGTGGAGAAGCTGGA	0.552000													14	70					0	0	0	0
NR1D1	9572	broad.mit.edu	37	17	38251870	38251870	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:38251870G>A	uc002htz.1	-	5	1701	c.1075C>T	c.(1075-1077)CGC>TGC	p.R359C	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_Intron	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	359					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					GGAGCCTGGCGCAGACCATTT	0.637000													4	84					0	0	0	0
KRT37	8688	broad.mit.edu	37	17	39580458	39580458	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:39580458C>T	uc002hwp.1	-	1	365	c.318G>A	c.(316-318)GAG>GAA	p.E106E	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	106	Coil 1A.|Rod.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				ACTTCATGGTCTCCTTCTCAT	0.572000													13	54					0	0	0	0
ACLY	47	broad.mit.edu	37	17	40063716	40063716	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:40063716G>A	uc002hyg.2	-	7	889	c.726C>T	c.(724-726)TTC>TTT	p.F242F	ACLY_uc002hyh.2_Silent_p.F242F|ACLY_uc002hyi.2_Silent_p.F296F|ACLY_uc010wfx.1_Silent_p.F296F|ACLY_uc010wfy.1_Intron	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	242					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CCTCCCGCCCGAAGGGGGGAG	0.582000													4	72					0	0	0	0
MAPT	4137	broad.mit.edu	37	17	44061080	44061080	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:44061080C>G	uc002ijr.3	+	6	1230	c.910C>G	c.(910-912)CAC>GAC	p.H304D	MAPT_uc010dau.2_Missense_Mutation_p.H304D|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	304					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				GTTCACGTTTCACGTGGAAAT	0.622000													12	61					0	0	0	0
CA4	762	broad.mit.edu	37	17	58235751	58235751	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:58235751G>A	uc002iym.3	+	7	782	c.688G>A	c.(688-690)GAT>AAT	p.D230N	CA4_uc010wou.1_RNA	NM_000717	NP_000708	P22748	CAH4_HUMAN	carbonic anhydrase IV precursor	230					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	ACCGACCTGCGATGAGAAGGT	0.612000													11	32					0	0	0	0
UNC13D	201294	broad.mit.edu	37	17	73831829	73831829	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:73831829C>T	uc002jpp.2	-	19	2006	c.1626G>A	c.(1624-1626)ACG>ACA	p.T542T	UNC13D_uc010wsk.1_Silent_p.T542T|UNC13D_uc002jpq.1_Silent_p.T192T	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	542	Interaction with RAB27A.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			CACCCACAACCGTCGTGTGGT	0.622000									Familial_Hemophagocytic_Lymphohistiocytosis				30	69					0	0	0	0
CDK3	1018	broad.mit.edu	37	17	73998157	73998157	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:73998157C>T	uc010dgt.2	+	4	325	c.249C>T	c.(247-249)CTC>CTT	p.L83L	CDK3_uc002jqg.3_Silent_p.L111L	NM_001258	NP_001249	Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	83	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						TTGAGTTCCTCAGCCAGGACC	0.572000													14	54					0	0	0	0
MYOM1	8736	broad.mit.edu	37	18	3129359	3129359	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr18:3129359G>C	uc002klp.2	-	18	2999	c.2665C>G	c.(2665-2667)CAA>GAA	p.Q889E	MYOM1_uc002klq.2_Intron	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	889						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CCCAGGTTTTGAGAGCTACTG	0.532000											OREG0024838	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	114					0	0	0	0
PTPRM	5797	broad.mit.edu	37	18	7955287	7955287	+	Missense_Mutation	SNP	C	T	T	rs150274533	by1000genomes	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr18:7955287C>T	uc002knn.3	+	7	1510	c.1007C>T	c.(1006-1008)ACG>ATG	p.T336M	PTPRM_uc010dkv.2_Missense_Mutation_p.T336M|PTPRM_uc010wzl.1_Missense_Mutation_p.T123M	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	336	Fibronectin type-III 1.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GTCGATTCCACGAGCTATAAA	0.572000													6	30					0	0	0	0
MC4R	4160	broad.mit.edu	37	18	58039474	58039474	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr18:58039474C>T	uc002lie.1	-	1	528	c.109G>A	c.(109-111)GAT>AAT	p.D37N		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	37	Extracellular (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				CACCCTCCATCAGAGTAGCCT	0.512000													15	44					0	0	0	0
CDH19	28513	broad.mit.edu	37	18	64176484	64176484	+	Splice_Site	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr18:64176484C>G	uc002lkc.1	-	11	1715	c.1577_splice	c.e11-1	p.D526_splice	CDH19_uc010dql.1_Intron|CDH19_uc010xey.1_Intron	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				GCTGTGTTATCTAAAACAAAA	0.343000													9	17					0	0	0	0
CNDP2	55748	broad.mit.edu	37	18	72180833	72180833	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr18:72180833G>A	uc002llm.1	+	8	944	c.782G>A	c.(781-783)GGC>GAC	p.G261D	CNDP2_uc002lln.1_Missense_Mutation_p.G177D|CNDP2_uc010dqs.2_Intron	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	261						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		CTGATCCCCGGCATTAACGAG	0.607000													3	30					0	0	0	0
TICAM1	148022	broad.mit.edu	37	19	4817044	4817044	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:4817044G>A	uc002mbi.2	-	2	1597	c.1346C>T	c.(1345-1347)TCA>TTA	p.S449L		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	449	TIR.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GATGAAAGCTGAGTGGTCTAT	0.632000													8	57					0	0	0	0
KDM4B	23030	broad.mit.edu	37	19	5131326	5131326	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:5131326G>A	uc002mbq.3	+	12	1781	c.1555G>A	c.(1555-1557)GAG>AAG	p.E519K	KDM4B_uc010xim.1_Missense_Mutation_p.E553K|KDM4B_uc002mbr.3_Missense_Mutation_p.E277K	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	519	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						TGAGGAGCTAGAGGCCAAGCC	0.687000													8	26					0	0	0	0
TUBB4	10382	broad.mit.edu	37	19	6495568	6495568	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:6495568G>A	uc002mfg.1	-	4	1049	c.942C>T	c.(940-942)GCC>GCT	p.A314A	TUBB4_uc002mff.1_Silent_p.A242A|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	314					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		GGAACACGGCGGCCACGGTCA	0.647000													24	99					0	0	0	0
MAP2K7	5609	broad.mit.edu	37	19	7968931	7968931	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:7968931C>T	uc002mit.2	+	1	167	c.102C>T	c.(100-102)ATC>ATT	p.I34I	MAP2K7_uc002mis.1_Silent_p.I34I|MAP2K7_uc002miv.2_Silent_p.I34I|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Silent_p.I34I|MAP2K7_uc010dvv.2_5'UTR	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	34					activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	ACCTGGATATCAGCCCCCAGC	0.398000													5	12					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9066948	9066948	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:9066948G>A	uc002mkp.2	-	3	20702	c.20498C>T	c.(20497-20499)TCA>TTA	p.S6833L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6835	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGAGCAGTGAGGTCATAGG	0.502000													10	62					0	0	0	0
SLC44A2	57153	broad.mit.edu	37	19	10747142	10747142	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:10747142C>T	uc002mpf.2	+	15	1516	c.1377C>T	c.(1375-1377)TTC>TTT	p.F459F	SLC44A2_uc002mpe.3_Silent_p.F457F|SLC44A2_uc002mpg.1_Silent_p.F179F|SLC44A2_uc002mph.2_Silent_p.F8F	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	459	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	TGGCCAACTTCGTGCTGGCGC	0.647000													34	76					0	0	0	0
ZNF490	57474	broad.mit.edu	37	19	12721450	12721450	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:12721450G>A	uc002mtz.2	-	1	174	c.45C>T	c.(43-45)CTC>CTT	p.L15L	ZNF791_uc002mua.2_5'Flank|ZNF791_uc010xml.1_5'Flank|ZNF791_uc010dyu.1_5'Flank|ZNF791_uc010xmm.1_5'Flank	NM_020714	NP_065765	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTGCTCCTCGAGGGGTCGCT	0.567000													14	30					0	0	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13915816	13915816	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:13915816C>T	uc002mxh.1	+	3	755	c.566C>T	c.(565-567)TCC>TTC	p.S189F	ZSWIM4_uc010xng.1_5'UTR	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	189							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CTGCCCATCTCCGAGACGCTC	0.637000											OREG0025298	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	39					0	0	0	0
SAMD1	90378	broad.mit.edu	37	19	14199324	14199324	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:14199324G>A	uc010xnl.1	-	7	1522	c.1522C>T	c.(1522-1524)CGC>TGC	p.R508C		NM_138352	NP_612361	Q6SPF0	SAMD1_HUMAN	sterile alpha motif domain containing 1	508	SAM.					cytoplasm|extracellular region					0		Renal(1328;0.00183)|Hepatocellular(1079;0.00826)		GBM - Glioblastoma multiforme(1328;0.000411)|STAD - Stomach adenocarcinoma(1328;0.00644)|Lung(535;0.199)		GGCCCGAGGCGGATGGACAGG	0.577000													10	36					0	0	0	0
SIN3B	23309	broad.mit.edu	37	19	16980676	16980676	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:16980676G>A	uc002ney.1	+	14	2322	c.2308G>A	c.(2308-2310)GAT>AAT	p.D770N	SIN3B_uc002nez.1_Missense_Mutation_p.D738N|SIN3B_uc010xpi.1_Missense_Mutation_p.D328N	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	770					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						GCCCCTGGACGATGTCTACAG	0.642000													7	25					0	0	0	0
KIRREL2	84063	broad.mit.edu	37	19	36357325	36357325	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:36357325C>T	uc002ocb.3	+	15	2270	c.2058C>T	c.(2056-2058)CCC>CCT	p.P686P	KIRREL2_uc002obz.3_Intron|KIRREL2_uc002oca.3_Intron|KIRREL2_uc002occ.3_Silent_p.P633P|KIRREL2_uc002ocd.3_Silent_p.P648P|APLP1_uc010xsz.1_5'Flank|APLP1_uc002oce.2_5'Flank|APLP1_uc002ocf.2_5'Flank|APLP1_uc002ocg.2_5'Flank	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	686	Pro-rich.|Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATCTGGCCCCCGGGACTCCCC	0.592000													26	71					0	0	0	0
WDR62	284403	broad.mit.edu	37	19	36558321	36558321	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:36558321C>T	uc002odc.2	+	6	766	c.675C>T	c.(673-675)TTC>TTT	p.F225F	WDR62_uc002odd.2_Silent_p.F225F|WDR62_uc002odb.2_Silent_p.F225F	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	225	WD 3.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGTTCTGGTTCTTGGAAGTCT	0.532000													8	56					0	0	0	0
ZNF568	374900	broad.mit.edu	37	19	37440743	37440743	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:37440743G>T	uc002ofc.2	+	7	1203	c.688G>T	c.(688-690)GAC>TAC	p.D230Y	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.D154Y|ZNF568_uc010efe.2_Missense_Mutation_p.D154Y|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	230	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTGTGGACAAGACTTCAGTCA	0.398000													14	72					2.61681e-11	2.80936e-11	1	0
LGALS4	3960	broad.mit.edu	37	19	39299490	39299490	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:39299490G>A	uc002ojg.2	-	3	447	c.233C>T	c.(232-234)ACG>ATG	p.T78M	LGALS4_uc010xuj.1_Missense_Mutation_p.T78M	NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	78	Galectin 1.				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GCCCTGCAACGTGTTGAAGAC	0.582000													11	37					0	0	0	0
PSG6	5675	broad.mit.edu	37	19	43421931	43421931	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:43421931G>A	uc002ovj.1	-	1	66	c.14C>T	c.(13-15)TCA>TTA	p.S5L	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ovf.1_Missense_Mutation_p.S5L|PSG6_uc002ovg.1_Missense_Mutation_p.S5L	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	5					female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GGGAGGGGCTGAGAGGGGTCC	0.597000													31	101					0	0	0	0
CD3EAP	10849	broad.mit.edu	37	19	45910392	45910392	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:45910392G>A	uc002pbq.1	+	2	551	c.63G>A	c.(61-63)AAG>AAA	p.K21K	PPP1R13L_uc002pbn.2_5'Flank|PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Silent_p.K23K	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	21					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		TTACCGCGAAGCCCCCAGCCT	0.597000													17	60					0	0	0	0
FUT2	2524	broad.mit.edu	37	19	49206875	49206875	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:49206875G>A	uc002pke.3	+	2	773	c.662G>A	c.(661-663)CGA>CAA	p.R221Q	FUT2_uc010emc.2_Missense_Mutation_p.R221Q	NM_001097638	NP_001091107	Q10981	FUT2_HUMAN	fucosyltransferase 2	221	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity	p.R221*(1)		central_nervous_system(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		GCCGACCGGCGATACCTACAG	0.607000													23	95					0	0	0	0
SIGLEC6	946	broad.mit.edu	37	19	52033148	52033148	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:52033148G>A	uc002pwy.2	-	5	1004	c.842C>T	c.(841-843)CCT>CTT	p.P281L	SIGLEC6_uc002pwz.2_Missense_Mutation_p.P265L|SIGLEC6_uc002pxa.2_Missense_Mutation_p.P281L|SIGLEC6_uc010ydb.1_Missense_Mutation_p.P218L|SIGLEC6_uc010ydc.1_Missense_Mutation_p.P281L|SIGLEC6_uc010eoz.1_Missense_Mutation_p.P259L|SIGLEC6_uc010epb.1_Missense_Mutation_p.P234L|SIGLEC6_uc010epa.1_Missense_Mutation_p.P270L	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	281	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CAGGTGTGCAGGGGGGTTGCC	0.617000													18	70					0	0	0	0
FPR2	2358	broad.mit.edu	37	19	52272800	52272800	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:52272800C>T	uc002pxr.2	+	2	934	c.889C>T	c.(889-891)CTC>TTC	p.L297F	FPR2_uc002pxs.3_Missense_Mutation_p.L297F|FPR2_uc010epf.2_Missense_Mutation_p.L297F	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	297	Helical; Name=7; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						CAACAGCTGCCTCAACCCCAT	0.542000													23	52					0	0	0	0
MIR519C	574466	broad.mit.edu	37	19	54189750	54189750	+	RNA	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:54189750G>A	hsa-mir-519c|MI0003148	+			c.28G>A			MIR1283-1_hsa-mir-1283-1|MI0003832_5'Flank																	0						CTAGAGGGAAGCGCTTTCTGT	0.388000													39	126					0	0	0	0
ZNF580	51157	broad.mit.edu	37	19	56154207	56154207	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr19:56154207C>T	uc002qlo.2	+	2	503	c.333C>T	c.(331-333)CGC>CGT	p.R111R	ZNF580_uc002qlm.2_Silent_p.R124R|ZNF581_uc002qln.2_Intron|ZNF580_uc002qlp.2_Silent_p.R111R|ZNF580_uc010ygd.1_Silent_p.R111R|ZNF581_uc002qlq.2_5'Flank	NM_207115	NP_996998	Q9UK33	ZN580_HUMAN	zinc finger protein 580	111	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		AGAGCCACCGCGTGTCGCACT	0.692000													3	17					0	0	0	0
RSAD2	91543	broad.mit.edu	37	2	7035928	7035928	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:7035928G>A	uc002qyp.1	+	6	1077	c.941G>A	c.(940-942)AGA>AAA	p.R314K		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	314					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		CTGAACTGTAGAAAGGGACGG	0.378000													12	50					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15519752	15519752	+	Silent	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:15519752G>C	uc002rcc.1	-	30	3590	c.3564C>G	c.(3562-3564)CTC>CTG	p.L1188L	NBAS_uc010exl.1_Silent_p.L260L|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1188										ovary(2)|liver(1)|skin(1)	4						AGCTATCAGTGAGGTTGGTAG	0.428000													18	49					0	0	0	0
GPR113	165082	broad.mit.edu	37	2	26533572	26533572	+	Silent	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:26533572G>C	uc002rhe.3	-	11	3024	c.3024C>G	c.(3022-3024)CTC>CTG	p.L1008L	GPR113_uc010yky.1_Silent_p.L939L|GPR113_uc002rhb.1_Silent_p.L611L|GPR113_uc010eyk.1_Silent_p.L809L|GPR113_uc002rhc.1_Silent_p.L611L|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	1008	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGGGTGTTGAGAATGGTGA	0.473000													6	10					0	0	0	0
GPR113	165082	broad.mit.edu	37	2	26533788	26533788	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:26533788G>A	uc002rhe.3	-	11	2808	c.2808C>T	c.(2806-2808)ATC>ATT	p.I936I	GPR113_uc010yky.1_Silent_p.I867I|GPR113_uc002rhb.1_Silent_p.I539I|GPR113_uc010eyk.1_Silent_p.I737I|GPR113_uc002rhc.1_Silent_p.I539I|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	936	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCACGCCTATGATGGCCAGCA	0.597000													9	12					0	0	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27907945	27907945	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:27907945G>A	uc002rlk.3	+	10	2199	c.1917G>A	c.(1915-1917)ATG>ATA	p.M639I		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	639						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					CAACTCTAATGAGAATGAAAG	0.299000													18	46					0	0	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27907958	27907958	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:27907958G>A	uc002rlk.3	+	10	2212	c.1930G>A	c.(1930-1932)GAG>AAG	p.E644K		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	644	Glu-rich.					cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					AATGAAAGATGAGCCTGAAGT	0.328000													21	42					0	0	0	0
LRPPRC	10128	broad.mit.edu	37	2	44128664	44128664	+	Splice_Site	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:44128664C>G	uc002rtr.2	-	32	3423	c.3365_splice	c.e32-1	p.E1122_splice	LRPPRC_uc010yob.1_Intron	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein						mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTCACAGCCTCTAAAATACAA	0.433000													8	31					0	0	0	0
CCDC88A	55704	broad.mit.edu	37	2	55561402	55561402	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:55561402A>T	uc002ryv.2	-	15	3397	c.2555T>A	c.(2554-2556)TTA>TAA	p.L852*	CCDC88A_uc010yoz.1_Nonsense_Mutation_p.L852*|CCDC88A_uc010ypa.1_Nonsense_Mutation_p.L852*|CCDC88A_uc010ypb.1_Nonsense_Mutation_p.L754*|CCDC88A_uc002ryu.2_Nonsense_Mutation_p.L135*|CCDC88A_uc002ryw.2_Nonsense_Mutation_p.L135*	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	852	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						ATTTTCTTCTAATGTGGTATC	0.323000													15	70					0	0	0	0
PCBP1	5093	broad.mit.edu	37	2	70315832	70315832	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:70315832G>A	uc002sgf.2	+	1	1248	c.957G>A	c.(955-957)GTG>GTA	p.V319V	ASPRV1_uc002sga.2_5'Flank|uc002sgb.1_5'Flank|uc002sgd.2_5'Flank|uc002sge.1_5'Flank	NM_006196	NP_006187	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	319	KH 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding				0						CCAACCCAGTGGAAGGCTCCT	0.512000													15	34					0	0	0	0
FBXO41	150726	broad.mit.edu	37	2	73492491	73492491	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:73492491C>T	uc002sjb.1	-	5	1666	c.1666G>A	c.(1666-1668)GAG>AAG	p.E556K		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	F-box protein 41	495						intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3						GCCTCTGACTCAGTGGTTCGG	0.687000													13	40					0	0	0	0
NCAPH	23397	broad.mit.edu	37	2	97035190	97035190	+	Silent	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:97035190C>G	uc002svz.1	+	17	2202	c.2118C>G	c.(2116-2118)CTC>CTG	p.L706L	NCAPH_uc010yum.1_Silent_p.L682L|NCAPH_uc010fhw.1_Silent_p.L695L|NCAPH_uc010yun.1_Silent_p.L570L|NCAPH_uc002swa.1_Silent_p.L301L	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	706					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				CTCAGAACCTCTCCATACCTC	0.433000													33	100					0	0	0	0
NCAPH	23397	broad.mit.edu	37	2	97035215	97035215	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:97035215C>G	uc002svz.1	+	17	2227	c.2143C>G	c.(2143-2145)CTC>GTC	p.L715V	NCAPH_uc010yum.1_Missense_Mutation_p.L691V|NCAPH_uc010fhw.1_Missense_Mutation_p.L704V|NCAPH_uc010yun.1_Missense_Mutation_p.L579V|NCAPH_uc002swa.1_Missense_Mutation_p.L310V	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	715					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				TTTTGCCTGTCTCCTACATTT	0.428000													34	105					0	0	0	0
TBC1D8	11138	broad.mit.edu	37	2	101624355	101624355	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:101624355G>A	uc010fiv.2	-	20	3482	c.3351C>T	c.(3349-3351)ATC>ATT	p.I1117I	RPL31_uc010yvu.1_Intron|RPL31_uc010yvv.1_Intron|RPL31_uc010fiu.1_Intron|TBC1D8_uc002tau.3_Silent_p.I874I	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	1117				I -> T (in Ref. 4; BAF85515).	blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						TGTACTGATTGATCTTGGCAT	0.383000													39	129					0	0	0	0
LCT	3938	broad.mit.edu	37	2	136590728	136590728	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:136590728C>G	uc002tuu.1	-	2	684	c.673G>C	c.(673-675)GAT>CAT	p.D225H		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	225	Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCCGGGATATCTTCAGCTCGC	0.517000													33	115					0	0	0	0
KYNU	8942	broad.mit.edu	37	2	143799685	143799685	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:143799685T>C	uc002tvl.2	+	14	1472	c.1342T>C	c.(1342-1344)TAT>CAT	p.Y448H	KYNU_uc010fnm.2_Missense_Mutation_p.Y448H	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	448					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	ccatgatgtttataaaTTTAC	0.284000													13	63					0	0	0	0
SLC4A10	57282	broad.mit.edu	37	2	162820729	162820729	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:162820729G>T	uc002ubx.3	+	22	3131	c.2947G>T	c.(2947-2949)GTG>TTG	p.V983L	SLC4A10_uc002uby.3_Missense_Mutation_p.V953L|SLC4A10_uc010zcs.1_Missense_Mutation_p.V964L	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	983	Extracellular (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						GCTTCGAAAAGTGCATCTCTT	0.378000													8	25					1.06961e-07	1.12943e-07	1	0
KBTBD10	10324	broad.mit.edu	37	2	170377507	170377507	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:170377507G>C	uc002ueu.1	+	5	1776	c.1699G>C	c.(1699-1701)GAC>CAC	p.D567H	KBTBD10_uc010zdh.1_Missense_Mutation_p.D505H	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	567	Kelch 5.				striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						TGAAGTCAATGACATATGGAA	0.338000													8	62					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179427277	179427277	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:179427277G>C	uc010zfg.1	-	275	76102	c.75878C>G	c.(75877-75879)TCT>TGT	p.S25293C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S18988C|TTN_uc010zfi.1_Missense_Mutation_p.S18921C|TTN_uc010zfj.1_Missense_Mutation_p.S18796C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26220							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTGGTTCAGACACTTTAAC	0.443000													10	48					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179638442	179638442	+	Silent	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:179638442C>G	uc010zfg.1	-	32	7565	c.7341G>C	c.(7339-7341)GTG>GTC	p.V2447V	TTN_uc010zfh.1_Silent_p.V2401V|TTN_uc010zfi.1_Silent_p.V2401V|TTN_uc010zfj.1_Silent_p.V2401V|TTN_uc002unb.2_Silent_p.V2447V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2447							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGGTGTTATCACGTCCACAC	0.373000													8	53					0	0	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801352	185801352	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:185801352C>A	uc002uph.2	+	4	1823	c.1229C>A	c.(1228-1230)ACT>AAT	p.T410N		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	410						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GTTAACATAACTATACATAAG	0.383000													23	68					4.54149e-19	4.95856e-19	1	0
HIBCH	26275	broad.mit.edu	37	2	191155142	191155142	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:191155142T>C	uc002uru.2	-	5	457	c.374A>G	c.(373-375)AAT>AGT	p.N125S	HIBCH_uc002urv.2_Missense_Mutation_p.N125S	NM_014362	NP_055177	Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-Coenzyme A hydrolase isoform	125					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			AACAGCATTATTCAGCATATA	0.343000													15	28					0	0	0	0
SGOL2	151246	broad.mit.edu	37	2	201436564	201436564	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:201436564G>A	uc002uvw.2	+	7	1608	c.1495G>A	c.(1495-1497)GAG>AAG	p.E499K	SGOL2_uc010zhd.1_Missense_Mutation_p.E499K|SGOL2_uc010zhe.1_Missense_Mutation_p.E499K	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	499					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						AATAACAAATGAGCAAGAGGA	0.338000													23	129					0	0	0	0
ANKZF1	55139	broad.mit.edu	37	2	220098944	220098944	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:220098944G>A	uc002vkg.2	+	9	1312	c.1138G>A	c.(1138-1140)GAA>AAA	p.E380K	ANKZF1_uc010zkv.1_Missense_Mutation_p.E324K|ANKZF1_uc010zkw.1_Missense_Mutation_p.E170K|ANKZF1_uc002vkh.2_Missense_Mutation_p.E170K|ANKZF1_uc002vki.2_Missense_Mutation_p.E380K|ANKZF1_uc002vkj.1_Missense_Mutation_p.E368K	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	380						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TACTGAGGAAGAAATAAGAAA	0.468000													9	51					0	0	0	0
SH3BP4	23677	broad.mit.edu	37	2	235962446	235962446	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:235962446G>A	uc002vvp.2	+	6	3271	c.2878G>A	c.(2878-2880)GAC>AAC	p.D960N	SH3BP4_uc010fym.2_Missense_Mutation_p.D942N|SH3BP4_uc002vvq.2_Missense_Mutation_p.D960N	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	960					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GGACCAGGACGACTTCGTGAT	0.622000													10	72					0	0	0	0
PDYN	5173	broad.mit.edu	37	20	1961196	1961196	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:1961196G>A	uc010gaj.2	-	3	780	c.538C>T	c.(538-540)CGC>TGC	p.R180C	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.R180C|PDYN_uc010zpt.1_Missense_Mutation_p.R25C	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	180					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity	p.R180C(1)		upper_aerodigestive_tract(1)|ovary(1)	2						GGGTATTTGCGCAAAAAGCCC	0.602000													26	66					0	0	0	0
TGM6	343641	broad.mit.edu	37	20	2375141	2375141	+	Silent	SNP	C	T	T	rs147506152	by1000genomes	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:2375141C>T	uc002wfy.1	+	2	112	c.51C>T	c.(49-51)GGC>GGT	p.G17G	TGM6_uc010gal.1_Silent_p.G17G	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	17					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CGAGGAATGGCGCTGCCCACC	0.647000													3	28					0	0	0	0
PAK7	57144	broad.mit.edu	37	20	9547019	9547019	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:9547019G>A	uc002wnl.2	-	6	1548	c.1003C>T	c.(1003-1005)CGA>TGA	p.R335*	PAK7_uc002wnk.2_Nonsense_Mutation_p.R335*|PAK7_uc002wnj.2_Nonsense_Mutation_p.R335*|PAK7_uc010gby.1_Nonsense_Mutation_p.R335*	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	335	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ATCTGTGCTCGATCGTAATCC	0.537000													23	90					0	0	0	0
NCOA6	23054	broad.mit.edu	37	20	33329679	33329679	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:33329679C>T	uc002xav.2	-	12	6952	c.4381G>A	c.(4381-4383)GAT>AAT	p.D1461N	NCOA6_uc002xaw.2_Missense_Mutation_p.D1461N	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1461					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						GGCTGCCCATCCTTTTTGGAC	0.448000													19	67					0	0	0	0
NCOA3	8202	broad.mit.edu	37	20	46256365	46256365	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:46256365G>A	uc002xtk.2	+	7	798	c.593G>A	c.(592-594)CGT>CAT	p.R198H	NCOA3_uc010ght.1_Missense_Mutation_p.R198H|NCOA3_uc002xtl.2_Missense_Mutation_p.R198H|NCOA3_uc002xtm.2_Missense_Mutation_p.R198H|NCOA3_uc002xtn.2_Missense_Mutation_p.R198H|NCOA3_uc010zyc.1_5'UTR	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	198					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TTTAATTGCCGTATGTTGATG	0.383000													24	60					0	0	0	0
ADRM1	11047	broad.mit.edu	37	20	60883183	60883183	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr20:60883183G>A	uc002ycn.2	+	8	1043	c.963G>A	c.(961-963)CCG>CCA	p.P321P	ADRM1_uc002yco.2_Silent_p.P321P	NM_007002	NP_008933	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1 precursor	321					proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			AGTCGCTGCCGCAGACCGCGG	0.647000													6	17					0	0	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812666	31812666	+	Silent	SNP	T	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr21:31812666T>A	uc002yod.2	+	1	21	c.21T>A	c.(19-21)TCT>TCA	p.S7S		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	7						intermediate filament					0						ACTGCAGCTCTGGAAACTTCT	0.438000													14	62					0	0	0	0
SFRS15	57466	broad.mit.edu	37	21	33067131	33067131	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr21:33067131G>A	uc002ypd.2	-	10	1657	c.1231C>T	c.(1231-1233)CAG>TAG	p.Q411*	SFRS15_uc002ype.2_Nonsense_Mutation_p.Q411*|SFRS15_uc010glu.2_Nonsense_Mutation_p.Q396*|SFRS15_uc002ypf.1_Nonsense_Mutation_p.Q85*	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	411						nucleus	nucleotide binding|RNA binding				0						TTTACCTGCTGATGCGGCTTC	0.408000													12	40					0	0	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671493	39671493	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr21:39671493C>G	uc002ywv.2	+	4	612	c.310C>G	c.(310-312)CAT>GAT	p.H104D	KCNJ15_uc002yww.2_Missense_Mutation_p.H104D|KCNJ15_uc002ywx.2_Missense_Mutation_p.H104D	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	104	Extracellular (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						CATTTCAAATCATACCCCCTG	0.493000													20	73					0	0	0	0
ADRBK2	157	broad.mit.edu	37	22	26118286	26118286	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:26118286G>A	uc003abx.3	+	21	2083	c.1936G>A	c.(1936-1938)GAG>AAG	p.E646K	ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	646	PH.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	GTGGAAGAAAGAGTTGAACGA	0.552000													23	84					0	0	0	0
TST	7263	broad.mit.edu	37	22	37407206	37407206	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:37407206G>A	uc003aqg.2	-	2	1456	c.756C>T	c.(754-756)GTC>GTT	p.V252V	TST_uc003aqh.2_Silent_p.V252V	NM_003312	NP_003303	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase	252	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity				0						GGCAGGCGGTGACTCCCTTGC	0.642000													5	30					0	0	0	0
EP300	2033	broad.mit.edu	37	22	41547912	41547912	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:41547912C>T	uc003azl.3	+	15	3288	c.2893C>T	c.(2893-2895)CAG>TAG	p.Q965*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	965					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AGTGAATTCTCAGGCCATTGC	0.478000			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				11	84					0	0	0	0
EFCAB6	64800	broad.mit.edu	37	22	43924776	43924776	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:43924776G>C	uc003bdy.1	-	32	4678	c.4463C>G	c.(4462-4464)TCA>TGA	p.S1488*	EFCAB6_uc003bdz.1_Nonsense_Mutation_p.S1336*|EFCAB6_uc010gzi.1_Nonsense_Mutation_p.S1336*	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1488	Interaction with AR.|Interaction with PARK7.|EF-hand 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				GGAGATTTTTGAAGACAGCGT	0.512000													8	91					0	0	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50659487	50659487	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:50659487G>A	uc003bkb.1	-	16	3813	c.3301C>T	c.(3301-3303)CGG>TGG	p.R1101W	TUBGCP6_uc003bka.1_Missense_Mutation_p.R188W|TUBGCP6_uc010har.1_Missense_Mutation_p.R1093W|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1101	9 X 27 AA tandem repeats.|3.				G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CACCGTGGCCGAGTGGGAGCC	0.597000													20	111					0	0	0	0
BHLHE40	8553	broad.mit.edu	37	3	5025027	5025027	+	Missense_Mutation	SNP	G	A	A	rs141865687		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:5025027G>A	uc003bqf.2	+	5	1196	c.889G>A	c.(889-891)GAT>AAT	p.D297N	BHLHE40_uc011asw.1_Missense_Mutation_p.D157N	NM_003670	NP_003661	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	297						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCTTTCGGATGATGAAGGCCA	0.562000													9	62					0	0	0	0
FBLN2	2199	broad.mit.edu	37	3	13655526	13655526	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:13655526G>A	uc011avb.1	+	5	1716	c.1591G>A	c.(1591-1593)GAG>AAG	p.E531K	FBLN2_uc011auz.1_Missense_Mutation_p.E557K|FBLN2_uc011ava.1_Missense_Mutation_p.E531K|FBLN2_uc011avc.1_Missense_Mutation_p.E531K|uc003byc.1_5'Flank	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	531	Anaphylatoxin-like 3.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CGTGCGGGCCGAGGGCCAGTC	0.597000													12	41					0	0	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37034418	37034418	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:37034418C>T	uc003cgk.2	-	1	378	c.151G>A	c.(151-153)GAA>AAA	p.E51K	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	51						endoplasmic reticulum					0						ACGTCGCGTTCGCGGGTAGCT	0.677000													9	30					0	0	0	0
OXSR1	9943	broad.mit.edu	37	3	38266161	38266161	+	Missense_Mutation	SNP	A	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:38266161A>C	uc003chy.2	+	8	1144	c.802A>C	c.(802-804)ATT>CTT	p.I268L	OXSR1_uc010hhb.2_Missense_Mutation_p.I202L|OXSR1_uc010hha.1_Missense_Mutation_p.I200L	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	268	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TAGAAAAATGATTTCATTGTG	0.313000													13	24					0	0	0	0
XIRP1	165904	broad.mit.edu	37	3	39228921	39228921	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:39228921G>A	uc003cjk.1	-	2	2237	c.2016C>T	c.(2014-2016)GGC>GGT	p.G672G	XIRP1_uc003cji.2_Silent_p.G672G|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	672							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CACAGGGACGGCCTGAGGCCT	0.612000													12	54					0	0	0	0
CCDC51	79714	broad.mit.edu	37	3	48475178	48475178	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:48475178C>A	uc003csz.2	-	3	537	c.416G>T	c.(415-417)CGT>CTT	p.R139L	CCDC51_uc003cta.2_Missense_Mutation_p.R30L|CCDC51_uc003ctb.2_Missense_Mutation_p.R30L|CCDC51_uc003ctc.2_Missense_Mutation_p.R139L|CCDC51_uc003ctd.2_Missense_Mutation_p.R30L	NM_024661	NP_078937	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	139	Potential.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CCTGGAGACACGGTCCAAGCG	0.597000													35	88					3.90053e-15	4.2443e-15	1	0
CACNA1D	776	broad.mit.edu	37	3	53839030	53839030	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:53839030G>A	uc003dgv.3	+	45	5769	c.5606G>A	c.(5605-5607)AGC>AAC	p.S1869N	CACNA1D_uc003dgu.3_Missense_Mutation_p.S1889N|CACNA1D_uc003dgy.3_Missense_Mutation_p.S1845N|CACNA1D_uc003dgw.3_Missense_Mutation_p.S1536N|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1869	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGCTACTACAGCAGATACCCA	0.522000													14	42					0	0	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64084754	64084754	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:64084754C>A	uc003dmf.2	-	8	3094	c.2508G>T	c.(2506-2508)CAG>CAT	p.Q836H		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	836						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		TTTTGCTCTTCTGTCTTTTCC	0.438000													29	72					9.39395e-14	1.01531e-13	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64619398	64619398	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:64619398G>A	uc003dmg.2	-	13	2046	c.2014C>T	c.(2014-2016)CGC>TGC	p.R672C	ADAMTS9_uc011bfo.1_Missense_Mutation_p.R644C|ADAMTS9_uc003dmh.1_Missense_Mutation_p.R501C|ADAMTS9_uc003dmk.1_Missense_Mutation_p.R672C	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	672	Cys-rich.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGGACCCAGCGCACATTGGGA	0.512000													43	225					0	0	0	0
LOC255025	255025	broad.mit.edu	37	3	94890846	94890846	+	RNA	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:94890846C>T	uc003drn.2	+	3		c.310C>T								Homo sapiens hypothetical protein LOC255025, mRNA (cDNA clone IMAGE:5267157).												0						AAAACAGCCTCTGCCATCACT	0.468000													6	11					0	0	0	0
POLQ	10721	broad.mit.edu	37	3	121207251	121207251	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:121207251C>T	uc003eee.3	-	16	4656	c.4527G>A	c.(4525-4527)ATG>ATA	p.M1509I	POLQ_uc003eed.2_Missense_Mutation_p.M681I	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1509					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		GGGGTTCTTTCATTTGCATAT	0.318000								DNA_polymerases_(catalytic_subunits)					18	58					0	0	0	0
POLQ	10721	broad.mit.edu	37	3	121207996	121207996	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:121207996C>T	uc003eee.3	-	16	3911	c.3782G>A	c.(3781-3783)AGA>AAA	p.R1261K	POLQ_uc003eed.2_Missense_Mutation_p.R433K	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1261					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TATCACAGTTCTGCTTATATC	0.343000								DNA_polymerases_(catalytic_subunits)					38	151					0	0	0	0
KALRN	8997	broad.mit.edu	37	3	123987636	123987636	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:123987636C>T	uc003ehg.2	+	5	624	c.497C>T	c.(496-498)TCC>TTC	p.S166F	KALRN_uc010hrv.1_Missense_Mutation_p.S166F|KALRN_uc003ehf.1_Missense_Mutation_p.S166F|KALRN_uc011bjy.1_Missense_Mutation_p.S166F	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	166	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GTGGACCCCTCCCAGCTGACG	0.577000													8	47					0	0	0	0
KALRN	8997	broad.mit.edu	37	3	124380748	124380748	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:124380748G>A	uc003ehg.2	+	45	6442	c.6315G>A	c.(6313-6315)ATG>ATA	p.M2105I	KALRN_uc003ehi.2_Missense_Mutation_p.M446I|KALRN_uc003ehk.2_Missense_Mutation_p.M408I|KALRN_uc011bjz.1_Missense_Mutation_p.M197I	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2104					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ATGACATGATGAATCTAGGAC	0.507000													28	89					0	0	0	0
ARMC8	25852	broad.mit.edu	37	3	137942337	137942337	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:137942337C>G	uc003esa.1	+	5	626	c.259C>G	c.(259-261)CTA>GTA	p.L87V	ARMC8_uc003erw.2_Missense_Mutation_p.L87V|ARMC8_uc003erx.2_Missense_Mutation_p.L87V|ARMC8_uc003ery.2_Missense_Mutation_p.L59V|ARMC8_uc003erz.2_Missense_Mutation_p.L59V|ARMC8_uc011bmf.1_Missense_Mutation_p.L101V|ARMC8_uc011bmg.1_Missense_Mutation_p.L101V|ARMC8_uc011bmh.1_Missense_Mutation_p.L59V|ARMC8_uc003esb.1_Missense_Mutation_p.L59V	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	101	ARM 2.						binding				0						TGTCAAGTCTCTACTGGACTG	0.413000													20	78					0	0	0	0
CPB1	1360	broad.mit.edu	37	3	148563304	148563304	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:148563304G>A	uc003ewl.2	+	9	895	c.872G>A	c.(871-873)CGC>CAC	p.R291H		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	291					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			GATTTCATCCGCAACAAACTC	0.463000													27	70					0	0	0	0
SOX2	6657	broad.mit.edu	37	3	181430864	181430864	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:181430864C>A	uc003fkx.2	+	1	1143	c.716C>A	c.(715-717)TCC>TAC	p.S239Y	SOX2OT_uc003fkv.2_Intron|SOX2OT_uc003fkw.3_Intron	NM_003106	NP_003097	P48431	SOX2_HUMAN	sex-determining region Y-box 2	239					cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			GCTCTTGGCTCCATGGGTTCG	0.652000			A		NSCLC|oesophageal squamous carcinoma		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						18	61					9.16793e-09	9.71256e-09	1	0
ABCF3	55324	broad.mit.edu	37	3	183910898	183910898	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:183910898G>A	uc003fmz.2	+	19	1892	c.1759G>A	c.(1759-1761)GAG>AAG	p.E587K	ABCF3_uc003fna.2_Missense_Mutation_p.E581K|ABCF3_uc003fnb.2_Missense_Mutation_p.E268K	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	587	ABC transporter 2.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGGCGGCCTGAGGAGGAGTA	0.632000													12	39					0	0	0	0
CHRD	8646	broad.mit.edu	37	3	184100495	184100495	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:184100495C>T	uc003fov.2	+	8	1161	c.915C>T	c.(913-915)CTC>CTT	p.L305L	CHRD_uc003fow.2_5'UTR|CHRD_uc003fox.2_Silent_p.L305L|CHRD_uc003foy.2_5'UTR|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'UTR	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	305	CHRD 2.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCTCACTCTCAGTGACACAG	0.592000													24	93					0	0	0	0
LSG1	55341	broad.mit.edu	37	3	194362875	194362875	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:194362875C>T	uc003fui.2	-	14	2214	c.1899G>A	c.(1897-1899)GCG>GCA	p.A633A		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	633					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		AGGGCTTCCCCGCCCCGTTCT	0.498000													21	74					0	0	0	0
NCBP2	22916	broad.mit.edu	37	3	196664450	196664450	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr3:196664450G>C	uc003fxd.1	-	3	420	c.330C>G	c.(328-330)ATC>ATG	p.I110M	NCBP2_uc003fxb.1_Missense_Mutation_p.I40M|NCBP2_uc011btz.1_Missense_Mutation_p.I92M|NCBP2_uc003fxc.1_RNA|NCBP2_uc003fxe.1_Missense_Mutation_p.I57M|NCBP2_uc003fxf.2_3'UTR	NM_007362	NP_031388	P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	110	RRM.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding				0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		CTGTGCGAATGATTCGGTCAT	0.532000													25	69					0	0	0	0
SH3TC1	54436	broad.mit.edu	37	4	8230222	8230222	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:8230222C>T	uc003gkv.3	+	12	2902	c.2801C>T	c.(2800-2802)TCG>TTG	p.S934L	SH3TC1_uc003gkw.3_Missense_Mutation_p.S858L|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	934							binding			large_intestine(2)|pancreas(1)	3						CGGCTGTTCTCGAGGCTGCCC	0.711000													12	27					0	0	0	0
LCORL	254251	broad.mit.edu	37	4	17847407	17847407	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:17847407C>G	uc003gpq.2	-	7	905	c.894G>C	c.(892-894)TTG>TTC	p.L298F	LCORL_uc011bxk.1_3'UTR	NM_153686	NP_710153	Q8N3X6	LCORL_HUMAN	ligand dependent nuclear receptor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						ATGCTGTTGTCAAATTCAGAT	0.383000													30	71					0	0	0	0
ARAP2	116984	broad.mit.edu	37	4	36230305	36230305	+	Silent	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:36230305C>G	uc003gsq.1	-	2	1142	c.804G>C	c.(802-804)GTG>GTC	p.V268V	ARAP2_uc003gsr.1_Silent_p.V268V	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	268					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TACGACTTCTCACAGGTGCTA	0.418000													24	91					0	0	0	0
LOC401127	401127	broad.mit.edu	37	4	39482422	39482422	+	RNA	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:39482422G>A	uc011byn.1	+	1		c.548G>A			LOC401127_uc011byo.1_RNA	NR_026854				Homo sapiens WD repeat domain 5 pseudogene (LOC401127), non-coding RNA.												0						AAACCTTGAAGATACGGGACG	0.463000													14	23					0	0	0	0
GABRG1	2565	broad.mit.edu	37	4	46043203	46043203	+	Silent	SNP	A	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:46043203A>G	uc003gxb.2	-	9	1352	c.1200T>C	c.(1198-1200)GAT>GAC	p.D400D		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	400	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		ACCCATAATCATCTTCTTGCG	0.423000													16	37					0	0	0	0
KDR	3791	broad.mit.edu	37	4	55968137	55968137	+	Silent	SNP	G	A	A	rs138304068		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:55968137G>A	uc003has.2	-	15	2495	c.2193C>T	c.(2191-2193)GAC>GAT	p.D731D	KDR_uc003hat.1_Silent_p.D731D	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	731	Ig-like C2-type 7.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGAGGCCTTCGTCCTCCTTCC	0.418000			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			18	65					0	0	0	0
CLOCK	9575	broad.mit.edu	37	4	56310880	56310880	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:56310880C>G	uc003haz.1	-	20	2538	c.1612G>C	c.(1612-1614)GAA>CAA	p.E538Q	CLOCK_uc003hba.1_Missense_Mutation_p.E538Q|CLOCK_uc010igu.1_RNA	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	538	Implicated in the circadian rhythmicity (By similarity).				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			ATATTTGCTTCTATCATGCGT	0.388000													13	50					0	0	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73414358	73414358	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:73414358G>C	uc003hgk.1	-	3	378	c.341C>G	c.(340-342)TCT>TGT	p.S114C		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	114					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGGCACCAGAGATGTCTCATG	0.463000													29	102					0	0	0	0
BANK1	55024	broad.mit.edu	37	4	102751026	102751026	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:102751026G>C	uc003hvy.3	+	2	406	c.132G>C	c.(130-132)TTG>TTC	p.L44F	BANK1_uc003hvx.3_Missense_Mutation_p.L29F|BANK1_uc010ill.2_Intron|BANK1_uc003hvz.3_Missense_Mutation_p.L14F	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	44	Interaction with ITPR2.				B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		CTCTGTACTTGACAGAAGTAT	0.333000													4	47					0	0	0	0
TACR3	6870	broad.mit.edu	37	4	104640753	104640753	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:104640753G>A	uc003hxe.1	-	1	223	c.80C>T	c.(79-81)TCG>TTG	p.S27L		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	27	Extracellular (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGCAGCTAGCGAGGCGGTCAG	0.682000													10	35					0	0	0	0
PCDH10	57575	broad.mit.edu	37	4	134076091	134076091	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:134076091G>A	uc003iha.2	+	3	3536	c.2710G>A	c.(2710-2712)GAC>AAC	p.D904N		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	904	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CCAGGAAGCCGACATAGTAAG	0.433000													12	26					0	0	0	0
FBXW7	55294	broad.mit.edu	37	4	153247366	153247366	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:153247366C>T	uc003ims.2	-	10	1585	c.1436G>A	c.(1435-1437)CGA>CAA	p.R479Q	FBXW7_uc011cii.1_Missense_Mutation_p.R479Q|FBXW7_uc003imt.2_Missense_Mutation_p.R479Q|FBXW7_uc011cih.1_Missense_Mutation_p.R303Q|FBXW7_uc003imq.2_Missense_Mutation_p.R399Q|FBXW7_uc003imr.2_Missense_Mutation_p.R361Q	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	479	WD 3.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R479Q(31)|p.R479L(7)|p.R479G(3)|p.R399Q(2)|p.R240L(1)|p.R399L(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403000			Mis|N|D|F		colorectal|endometrial|T-ALL								12	38					0	0	0	0
MORF4	10934	broad.mit.edu	37	4	174537509	174537509	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:174537509G>T	uc011cke.1	-	1	286	c.286C>A	c.(286-288)CTT>ATT	p.L96I		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TCGGCAGGAAGATAGAAGAGC	0.378000													29	146					1.39806e-14	1.51613e-14	1	0
NEIL3	55247	broad.mit.edu	37	4	178272586	178272586	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:178272586C>T	uc003iut.2	+	7	1039	c.922C>T	c.(922-924)CAT>TAT	p.H308Y	NEIL3_uc010irs.2_Intron	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	308					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		CAGGGTGGATCATGTTATGGA	0.398000								BER_DNA_glycosylases					34	75					0	0	0	0
CDKN2AIP	55602	broad.mit.edu	37	4	184367411	184367411	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:184367411C>T	uc003ivp.1	+	3	736	c.574C>T	c.(574-576)CGG>TGG	p.R192W	CDKN2AIP_uc003ivq.1_5'UTR	NM_017632	NP_060102	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	192	Ser-rich.				negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding				0		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GAACTCAGCTCGGAGCTCTGG	0.512000													6	44					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187531171	187531171	+	Splice_Site	SNP	T	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:187531171T>A	uc003izf.2	-	15	10042	c.9854_splice	c.e15-1	p.G3285_splice		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATACGGCCCCTGAATAGAAAT	0.413000										HNSCC(5;0.00058)			5	12					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187541129	187541129	+	Missense_Mutation	SNP	A	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:187541129A>C	uc003izf.2	-	10	6799	c.6611T>G	c.(6610-6612)GTG>GGG	p.V2204G		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2204	Extracellular (Potential).|Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTTAGCCTGCACGTGGACCAC	0.483000										HNSCC(5;0.00058)			29	102					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187541201	187541201	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr4:187541201G>A	uc003izf.2	-	10	6727	c.6539C>T	c.(6538-6540)CCT>CTT	p.P2180L		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2180	Extracellular (Potential).|Cadherin 19.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTCAAACACAGGCATGGCTTT	0.483000										HNSCC(5;0.00058)			9	51					0	0	0	0
SLC9A3	6550	broad.mit.edu	37	5	482690	482690	+	Missense_Mutation	SNP	G	C	C	rs141238439		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:482690G>C	uc003jbe.2	-	7	1441	c.1329C>G	c.(1327-1329)ATC>ATG	p.I443M	SLC9A3_uc011clx.1_Missense_Mutation_p.I443M	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	443	Helical; Name=M/M10; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AGAACACTACGATGATGGTGG	0.662000													15	66					0	0	0	0
GHR	2690	broad.mit.edu	37	5	42718786	42718786	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:42718786G>A	uc003jmt.2	+	10	1220	c.1177G>A	c.(1177-1179)GAC>AAC	p.D393N	GHR_uc011cpq.1_Missense_Mutation_p.D206N	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	393	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTGTGAACCTGACATTCTGGA	0.473000													20	76					0	0	0	0
PARP8	79668	broad.mit.edu	37	5	50055555	50055555	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:50055555G>A	uc003jon.3	+	5	445	c.263G>A	c.(262-264)AGA>AAA	p.R88K	PARP8_uc011cpz.1_Intron|PARP8_uc003joo.2_Missense_Mutation_p.R88K|PARP8_uc003jop.2_Missense_Mutation_p.R88K	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	88						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				ATTTTTCATAGAATAGCAACA	0.259000													9	48					0	0	0	0
PDE4D	5144	broad.mit.edu	37	5	58289223	58289223	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:58289223C>G	uc003jsa.2	-	7	1163	c.991G>C	c.(991-993)GAG>CAG	p.E331Q	PDE4D_uc003jrx.2_Missense_Mutation_p.E195Q|PDE4D_uc003jry.2_Missense_Mutation_p.E29Q|PDE4D_uc003jrz.2_Missense_Mutation_p.E267Q|PDE4D_uc003jsb.2_Missense_Mutation_p.E270Q|PDE4D_uc003jrt.2_Missense_Mutation_p.E29Q|PDE4D_uc003jru.2_Missense_Mutation_p.E107Q|PDE4D_uc003jrv.2_Missense_Mutation_p.E201Q|PDE4D_uc003jrw.2_Missense_Mutation_p.E209Q|PDE4D_uc010iwi.1_3'UTR|PDE4D_uc003jrs.2_Missense_Mutation_p.E40Q	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	331					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	GATATAAACTCTGACACTTGA	0.343000													12	41					0	0	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65339965	65339965	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:65339965G>A	uc003juk.1	+	17	1737	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K	ERBB2IP_uc003juh.1_Missense_Mutation_p.E477K|ERBB2IP_uc003jui.1_Missense_Mutation_p.E477K|ERBB2IP_uc003juj.1_Missense_Mutation_p.E477K|ERBB2IP_uc011cqx.1_Missense_Mutation_p.E477K|ERBB2IP_uc011cqy.1_Missense_Mutation_p.E477K|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.E477K|ERBB2IP_uc003jul.1_Missense_Mutation_p.E477K	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	477					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		ATTTCTCTAGGAGGGAAATTT	0.284000													10	37					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	90103466	90103466	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:90103466T>C	uc003kju.2	+	73	14980	c.14884T>C	c.(14884-14886)TGG>CGG	p.W4962R	GPR98_uc003kjt.2_Missense_Mutation_p.W2668R|GPR98_uc003kjw.2_Missense_Mutation_p.W623R	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4962	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGTTTTCCTGTGGACGTTTCC	0.468000													10	28					0	0	0	0
SHROOM1	134549	broad.mit.edu	37	5	132159668	132159668	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:132159668G>A	uc003kxx.2	-	7	2490	c.1685C>T	c.(1684-1686)TCC>TTC	p.S562F	SHROOM1_uc003kxy.1_Missense_Mutation_p.S562F	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	562	ASD2.				actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCTGGGCTGGGAAGCAAGAGG	0.632000													18	32					0	0	0	0
CTNNA1	1495	broad.mit.edu	37	5	138266343	138266343	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:138266343G>A	uc003ldh.2	+	15	2287	c.2192G>A	c.(2191-2193)CGA>CAA	p.R731Q	CTNNA1_uc011cyx.1_Missense_Mutation_p.R628Q|CTNNA1_uc011cyy.1_Missense_Mutation_p.R608Q|CTNNA1_uc003ldi.2_Missense_Mutation_p.R429Q|CTNNA1_uc003ldj.2_Missense_Mutation_p.R731Q|CTNNA1_uc003ldl.2_Missense_Mutation_p.R361Q	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	731					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GACTTTACCCGGTGAGCAGCA	0.577000													19	78					0	0	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140800862	140800862	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:140800862C>T	uc003lkq.1	+	1	326	c.68C>T	c.(67-69)ACG>ATG	p.T23M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.T23M|PCDHGA11_uc003lkp.1_Missense_Mutation_p.T23M	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	23					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCTGGGGACGCTGCGGGGG	0.622000													4	25					0	0	0	0
ARSI	340075	broad.mit.edu	37	5	149677914	149677914	+	Silent	SNP	G	A	A	rs150264448	byFrequency	TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:149677914G>A	uc003lrv.2	-	2	1162	c.573C>T	c.(571-573)TTC>TTT	p.F191F		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	191						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGTGCAGGTCGAAGCCGCACA	0.627000													5	23					0	0	0	0
FAT2	2196	broad.mit.edu	37	5	150946494	150946494	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:150946494G>T	uc003lue.3	-	1	2012	c.1999C>A	c.(1999-2001)CCT>ACT	p.P667T	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.P667T	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	667	Extracellular (Potential).|Cadherin 5.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATGTTACAGGAACTTCAAAA	0.423000													22	99					3.62473e-10	3.86558e-10	1	0
FAT2	2196	broad.mit.edu	37	5	150946976	150946976	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:150946976G>A	uc003lue.3	-	1	1530	c.1517C>T	c.(1516-1518)TCT>TTT	p.S506F	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.S506F	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	506	Cadherin 4.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGGTCAATAGAAAATGGCAA	0.483000													10	59					0	0	0	0
C1QTNF2	114898	broad.mit.edu	37	5	159776351	159776351	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:159776351C>T	uc003lyd.2	-	3	821	c.817G>A	c.(817-819)GGC>AGC	p.G273S		NM_031908	NP_114114	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	228	C1q.					collagen				skin(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCGTGGTTGCCGGTGTTGGCA	0.577000													4	91					0	0	0	0
WWC1	23286	broad.mit.edu	37	5	167812240	167812240	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:167812240G>A	uc003lzu.2	+	3	347	c.254G>A	c.(253-255)CGA>CAA	p.R85Q	WWC1_uc003lzv.2_Missense_Mutation_p.R85Q|WWC1_uc011den.1_Missense_Mutation_p.R85Q	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	85	WW 2.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GAGGATCCTCGAGTACAATGG	0.527000													5	23					0	0	0	0
DOCK2	1794	broad.mit.edu	37	5	169503008	169503008	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:169503008C>T	uc003maf.2	+	47	4866	c.4786C>T	c.(4786-4788)CGA>TGA	p.R1596*	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Nonsense_Mutation_p.R1088*|DOCK2_uc003mah.2_Nonsense_Mutation_p.R152*	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1596	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATAACTTGCGACCCTTCCA	0.502000													34	86					0	0	0	0
CNOT6	57472	broad.mit.edu	37	5	179998330	179998330	+	Silent	SNP	G	A	A	rs34154769		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:179998330G>A	uc003mlx.2	+	11	1708	c.1359G>A	c.(1357-1359)GGG>GGA	p.G453G	CNOT6_uc010jld.2_Silent_p.G453G|CNOT6_uc010jle.2_Silent_p.G448G	NM_015455	NP_056270	Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	453					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding				0	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)		GCTGTCATGGGAAGAATGGAA	0.403000													26	51					0	0	0	0
BTN3A3	10384	broad.mit.edu	37	6	26452578	26452578	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:26452578C>T	uc003nhz.2	+	11	1874	c.1694C>T	c.(1693-1695)TCC>TTC	p.S565F	BTN3A3_uc003nia.2_Missense_Mutation_p.S523F|BTN3A3_uc011dkn.1_Missense_Mutation_p.S516F	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	565	Cytoplasmic (Potential).					integral to membrane					0						GCTGAGGTCTCCCCTTCTGCA	0.383000													9	19					0	0	0	0
PPP1R11	6992	broad.mit.edu	37	6	30037047	30037047	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:30037047C>G	uc003npb.2	+	3	601	c.345C>G	c.(343-345)GAC>GAG	p.D115E	PPP1R11_uc010jrw.2_RNA|PPP1R11_uc003npc.2_RNA	NM_021959	NP_068778	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor)	115	Pro-rich.					soluble fraction	protein binding|protein phosphatase inhibitor activity			ovary(1)|lung(1)|skin(1)	3						AGCCTCCTGACCCTTCCCAGC	0.597000													19	88					0	0	0	0
ITPR3	3710	broad.mit.edu	37	6	33636878	33636878	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:33636878G>A	uc011drk.1	+	18	2353	c.2134G>A	c.(2134-2136)GCC>ACC	p.A712T		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	712	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GAGGCAGCTGGCCCAGGAGGC	0.602000													7	82					0	0	0	0
TTBK1	84630	broad.mit.edu	37	6	43230734	43230734	+	Silent	SNP	C	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:43230734C>A	uc003ouq.1	+	13	1911	c.1632C>A	c.(1630-1632)GTC>GTA	p.V544V	TTBK1_uc011dvg.1_Silent_p.V67V	NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	544						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			AAGAGTGGGTCATCATCGACA	0.642000													10	10					1.58986e-06	1.66237e-06	1	0
LRRC1	55227	broad.mit.edu	37	6	53761313	53761313	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:53761313C>T	uc003pcd.1	+	5	741	c.464C>T	c.(463-465)TCA>TTA	p.S155L		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	155	LRR 7.					cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		AACCTGGCTTCACTGGAACTG	0.368000													14	51					0	0	0	0
HTR1E	3354	broad.mit.edu	37	6	87725456	87725456	+	Missense_Mutation	SNP	C	T	T	rs143974435		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:87725456C>T	uc003pli.2	+	2	1107	c.404C>T	c.(403-405)ACG>ATG	p.T135M		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	135	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	AGGAAGAGGACGGCCAAGAGG	0.577000													19	44					0	0	0	0
REV3L	5980	broad.mit.edu	37	6	111678329	111678329	+	Splice_Site	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:111678329C>G	uc003puy.3	-	18	7396	c.7073_splice	c.e18-1	p.D2358_splice	REV3L_uc003pux.3_Splice_Site_p.D2280_splice|REV3L_uc003puz.3_Splice_Site_p.D2280_splice|REV3L_uc003pva.1_Splice_Site	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta						DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TATCTGATATCTAAAAAACAA	0.264000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					10	35					0	0	0	0
KPNA5	3841	broad.mit.edu	37	6	117047696	117047696	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:117047696G>C	uc003pxh.2	+	12	1295	c.1164G>C	c.(1162-1164)GAG>GAC	p.E388D		NM_002269	NP_002260	O15131	IMA5_HUMAN	karyopherin alpha 5	385	NLS binding site (minor) (By similarity).|ARM 8.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		TTTTGATTGAGATTCTTCAGA	0.338000													22	67					0	0	0	0
AGPAT4	56895	broad.mit.edu	37	6	161575246	161575246	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:161575246C>G	uc003qtr.1	-	4	672	c.445G>C	c.(445-447)GAG>CAG	p.E149Q	AGPAT4_uc003qts.1_Missense_Mutation_p.E9Q|AGPAT4_uc011egb.1_Intron|AGPAT4_uc003qtt.1_RNA|AGPAT4_uc011egc.1_Missense_Mutation_p.E149Q|AGPAT4_uc011egd.1_Missense_Mutation_p.E87Q|AGPAT4_uc011ege.1_Missense_Mutation_p.G92A	NM_020133	NP_064518	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	149					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding				0		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		CGATCCTGCTCCCACTTGCGC	0.562000													11	62					0	0	0	0
T	6862	broad.mit.edu	37	6	166580264	166580264	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:166580264G>A	uc003quu.1	-	3	780	c.287C>T	c.(286-288)GCG>GTG	p.A96V	T_uc003qut.1_Missense_Mutation_p.A96V|T_uc003quv.1_Missense_Mutation_p.A96V	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	96	T-box.				anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		GTTGTCCGCCGCCACGAAGTC	0.657000									Chordoma_Familial_Clustering_of				5	51					0	0	0	0
COX19	90639	broad.mit.edu	37	7	1012890	1012890	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:1012890G>A	uc003sjp.1	-	2	211	c.121C>T	c.(121-123)CTT>TTT	p.L41F	ADAP1_uc010ksc.2_5'UTR	NM_001031617	NP_001026788	Q49B96	COX19_HUMAN	COX19 cytochrome c oxidase assembly homolog	41	CHCH.					cytosol					0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;2.15e-15)		TTGTTATGAAGACACTTCATG	0.343000													9	56					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21750198	21750198	+	Silent	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:21750198C>G	uc003svc.2	+	42	6763	c.6732C>G	c.(6730-6732)CTC>CTG	p.L2244L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2244	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TTATAGGTCTCTTCTCATCCA	0.348000									Kartagener_syndrome				4	19					0	0	0	0
FAM188B	84182	broad.mit.edu	37	7	30830790	30830790	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:30830790C>T	uc003tbt.2	+	5	750	c.673C>T	c.(673-675)CAC>TAC	p.H225Y	FAM188B_uc010kwe.2_Missense_Mutation_p.H196Y	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	225											0						GGATTCTTTTCACAGACACTA	0.438000													48	149					0	0	0	0
PDE1C	5137	broad.mit.edu	37	7	31918650	31918650	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:31918650C>G	uc003tcm.1	-	4	853	c.384G>C	c.(382-384)AAG>AAC	p.K128N	PDE1C_uc003tcn.1_Missense_Mutation_p.K128N|PDE1C_uc003tco.1_Missense_Mutation_p.K188N|PDE1C_uc003tcr.2_Missense_Mutation_p.K128N|PDE1C_uc003tcs.2_Missense_Mutation_p.K128N	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	128					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			GAACGATGCTCTTGAACCGGG	0.532000													21	62					0	0	0	0
ABCA13	154664	broad.mit.edu	37	7	48237849	48237849	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:48237849G>A	uc003toq.2	+	3	204	c.179G>A	c.(178-180)CGA>CAA	p.R60Q	ABCA13_uc003top.2_Missense_Mutation_p.R60Q|ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	60					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTGCAGCCCCGAGATCTACCC	0.408000													6	18					0	0	0	0
ABCA13	154664	broad.mit.edu	37	7	48284261	48284261	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:48284261C>G	uc003toq.2	+	11	1376	c.1351C>G	c.(1351-1353)CTC>GTC	p.L451V	ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	451					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TGATGGAGCTCTCAGAAATGC	0.428000													11	53					0	0	0	0
PEX1	5189	broad.mit.edu	37	7	92146808	92146808	+	Missense_Mutation	SNP	G	C	C	rs137856931		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:92146808G>C	uc003uly.2	-	5	1117	c.1021C>G	c.(1021-1023)CCA>GCA	p.P341A	PEX1_uc011khr.1_Missense_Mutation_p.P133A|PEX1_uc010ley.2_Missense_Mutation_p.P341A|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	341					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TGTTGCTTTGGAGAAAGTAGC	0.368000													13	39					0	0	0	0
ZAN	7455	broad.mit.edu	37	7	100345237	100345237	+	Silent	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:100345237C>G	uc003uwj.2	+	9	1161	c.996C>G	c.(994-996)GTC>GTG	p.V332V	ZAN_uc003uwk.2_Silent_p.V332V|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	332	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTGTTTCTGTCAATTACACAG	0.488000													14	45					0	0	0	0
ZAN	7455	broad.mit.edu	37	7	100346010	100346010	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:100346010C>T	uc003uwj.2	+	11	1331	c.1166C>T	c.(1165-1167)TCC>TTC	p.S389F	ZAN_uc003uwk.2_Missense_Mutation_p.S389F|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	389	MAM 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GTCCAGACTTCCGGGGATGGT	0.537000													12	47					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103151303	103151303	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:103151303A>G	uc003vca.2	-	51	8429	c.8269T>C	c.(8269-8271)TTC>CTC	p.F2757L	RELN_uc010liz.2_Missense_Mutation_p.F2757L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2757					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCACCTTGAATTGCATAATC	0.388000													8	28					0	0	0	0
RINT1	60561	broad.mit.edu	37	7	105183014	105183014	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:105183014C>G	uc003vda.1	+	4	664	c.433C>G	c.(433-435)CTT>GTT	p.L145V	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	145					cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						GATGGACGATCTTGGAACCAT	0.413000													19	34					0	0	0	0
NRCAM	4897	broad.mit.edu	37	7	107875082	107875082	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:107875082C>T	uc003vfb.2	-	6	646	c.175G>A	c.(175-177)GAC>AAC	p.D59N	NRCAM_uc003vfc.2_Missense_Mutation_p.D53N|NRCAM_uc011kmk.1_Missense_Mutation_p.D54N|NRCAM_uc003vfd.2_Missense_Mutation_p.D54N|NRCAM_uc003vfe.2_Missense_Mutation_p.D54N	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	59	Ig-like 1.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TCCCGAGGGTCAATAATGTAA	0.358000													20	55					0	0	0	0
CFTR	1080	broad.mit.edu	37	7	117227829	117227829	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:117227829C>A	uc003vjd.2	+	12	1753	c.1621C>A	c.(1621-1623)CTT>ATT	p.L541I	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	541	Cytoplasmic (Potential).|ABC transporter 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CAATATAGTTCTTGGAGAAGG	0.358000									Cystic_Fibrosis				18	29					5.35356e-11	5.72831e-11	1	0
NUP205	23165	broad.mit.edu	37	7	135292096	135292096	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:135292096C>T	uc003vsw.2	+	22	3203	c.3172C>T	c.(3172-3174)CAG>TAG	p.Q1058*		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1058					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						AGAATCTCCTCAGCTGGCTGA	0.498000													21	38					0	0	0	0
TMUB1	83590	broad.mit.edu	37	7	150779330	150779330	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:150779330C>T	uc003wjb.2	-	1	436	c.321G>A	c.(319-321)CTG>CTA	p.L107L	FASTK_uc003wiw.1_5'Flank|FASTK_uc003wix.1_5'Flank|FASTK_uc003wiy.1_5'Flank|FASTK_uc003wiz.1_5'Flank|FASTK_uc003wja.1_5'Flank|TMUB1_uc003wjc.2_Silent_p.L107L|TMUB1_uc003wjd.2_Silent_p.L107L	NM_031434	NP_113622	Q9BVT8	TMUB1_HUMAN	transmembrane and ubiquitin-like domain	107	Ubiquitin-like.					cytoplasm|integral to membrane|nucleus					0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGAGGAATTTCAGCCGTAGCA	0.597000													68	200					0	0	0	0
MTMR9	66036	broad.mit.edu	37	8	11152790	11152790	+	Silent	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:11152790G>A	uc003wtm.2	+	2	668	c.270G>A	c.(268-270)TTG>TTA	p.L90L	MTMR9_uc010lrx.2_5'UTR|MTMR9_uc011kxa.1_Silent_p.L5L	NM_015458	NP_056273	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	90						cytoplasm	phosphatase activity|protein binding				0			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		AGGAATGCTTGAATATAGCCA	0.323000													16	115					0	0	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24256527	24256527	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:24256527G>T	uc003xdz.2	+	9	1123	c.903G>T	c.(901-903)AAG>AAT	p.K301N	ADAMDEC1_uc010lub.2_Missense_Mutation_p.K222N|ADAMDEC1_uc011lab.1_Missense_Mutation_p.K222N	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	301	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		TGGGGAAAAAGATCCACGACC	0.512000													7	25					3.09899e-07	3.26155e-07	1	0
MOS	4342	broad.mit.edu	37	8	57025568	57025568	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:57025568G>A	uc011leb.1	-	1	974	c.974C>T	c.(973-975)GCG>GTG	p.A325V		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	325	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			CCTCTGCGCCGCGCTGGGTCT	0.627000													8	32					0	0	0	0
C8orf45	157777	broad.mit.edu	37	8	67808488	67808488	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:67808488C>T	uc003xwz.3	+	11	1534	c.1363C>T	c.(1363-1365)CAG>TAG	p.Q455*	C8orf45_uc011lev.1_Nonsense_Mutation_p.Q455*|C8orf45_uc011lew.1_Nonsense_Mutation_p.Q386*|C8orf45_uc011lex.1_Nonsense_Mutation_p.Q213*|C8orf45_uc003xwy.3_Nonsense_Mutation_p.Q455*	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	455					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TTTTCCAGTTCAGTGCAGTTT	0.388000													14	69					0	0	0	0
CCNE2	9134	broad.mit.edu	37	8	95902690	95902690	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:95902690C>T	uc003yhc.2	-	6	515	c.406G>A	c.(406-408)GAC>AAC	p.D136N	CCNE2_uc003yhd.2_Missense_Mutation_p.D136N	NM_057749	NP_477097	O96020	CCNE2_HUMAN	cyclin E2	136					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding				0	Breast(36;8.75e-07)					GGTTCCAAGTCAGAATGCAGA	0.373000													45	190					0	0	0	0
COL14A1	7373	broad.mit.edu	37	8	121381598	121381598	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:121381598C>T	uc003yox.2	+	47	5450	c.5185C>T	c.(5185-5187)CCT>TCT	p.P1729S	COL14A1_uc003yoz.2_Missense_Mutation_p.P694S	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1729	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GCCTGGCAGCCCTGGGCCCCC	0.582000													18	56					0	0	0	0
PLEC	5339	broad.mit.edu	37	8	144997457	144997457	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr8:144997457C>T	uc003zaf.1	-	31	7221	c.7051G>A	c.(7051-7053)GCG>ACG	p.A2351T	PLEC_uc003zab.1_Missense_Mutation_p.A2214T|PLEC_uc003zac.1_Missense_Mutation_p.A2218T|PLEC_uc003zad.2_Missense_Mutation_p.A2214T|PLEC_uc003zae.1_Missense_Mutation_p.A2182T|PLEC_uc003zag.1_Missense_Mutation_p.A2192T|PLEC_uc003zah.2_Missense_Mutation_p.A2200T|PLEC_uc003zaj.2_Missense_Mutation_p.A2241T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2351	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTGGCCTCCGCCTTCAGCCGC	0.662000													5	11					0	0	0	0
KIF24	347240	broad.mit.edu	37	9	34286638	34286638	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:34286638C>G	uc003zua.3	-	6	1312	c.1192G>C	c.(1192-1194)GAC>CAC	p.D398H	KIF24_uc010mkb.2_Missense_Mutation_p.D429H	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	398	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			TCCACACTGTCCACCTGAAGC	0.443000													9	55					0	0	0	0
KIAA1045	23349	broad.mit.edu	37	9	34976157	34976157	+	Silent	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:34976157C>T	uc003zvq.2	+	4	751	c.573C>T	c.(571-573)ATC>ATT	p.I191I	KIAA1045_uc003zvr.2_Silent_p.I191I	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	191							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			AGGACAACATCAACTTGCTGC	0.458000													14	36					0	0	0	0
FAM74A3	728495	broad.mit.edu	37	9	40716111	40716111	+	RNA	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:40716111C>T	uc010mmk.2	+	1		c.588C>T				NR_026801				Homo sapiens family with sequence similarity 74, member A3 (FAM74A3), non-coding RNA.											skin(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CAGACGCTGTCTGCAAGAAGA	0.537000													9	50					0	0	0	0
ANKRD20A4	728747	broad.mit.edu	37	9	69420272	69420272	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:69420272G>A	uc004afn.2	+	13	1274	c.1162G>A	c.(1162-1164)GGA>AGA	p.G388R		NM_001098805	NP_001092275	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	388											0						GGTCAAAGAAGGAAATAATAC	0.259000													3	45					0	0	0	0
TRPM3	80036	broad.mit.edu	37	9	73225627	73225627	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:73225627C>G	uc004aid.2	-	18	2773	c.2529G>C	c.(2527-2529)AAG>AAC	p.K843N	TRPM3_uc004ahu.2_Missense_Mutation_p.K673N|TRPM3_uc004ahv.2_Missense_Mutation_p.K645N|TRPM3_uc004ahw.2_Missense_Mutation_p.K715N|TRPM3_uc004ahx.2_Missense_Mutation_p.K702N|TRPM3_uc004ahy.2_Missense_Mutation_p.K705N|TRPM3_uc004ahz.2_Missense_Mutation_p.K692N|TRPM3_uc004aia.2_Missense_Mutation_p.K690N|TRPM3_uc004aib.2_Missense_Mutation_p.K680N|TRPM3_uc004aic.2_Missense_Mutation_p.K843N	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	868	Extracellular (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CTTCATCCTTCTTCCTGGAGG	0.388000													12	94					0	0	0	0
GOLM1	51280	broad.mit.edu	37	9	88650317	88650317	+	Silent	SNP	G	A	A	rs147755244		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:88650317G>A	uc004aol.2	-	8	1179	c.981C>T	c.(979-981)GAC>GAT	p.D327D	GOLM1_uc004aom.2_Silent_p.D327D	NM_016548	NP_057632	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1	327	Lumenal (Potential).					Golgi apparatus|integral to plasma membrane					0						CCTCCTGTCCGTCGGGGATGA	0.637000											OREG0019278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	66					0	0	0	0
GSN	2934	broad.mit.edu	37	9	124091231	124091231	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:124091231A>G	uc004blf.1	+	14	2039	c.1978A>G	c.(1978-1980)AAG>GAG	p.K660E	GSN_uc004bld.1_Missense_Mutation_p.K609E|GSN_uc010mvq.1_Missense_Mutation_p.K620E|GSN_uc010mvr.1_Missense_Mutation_p.K620E|GSN_uc010mvu.1_Missense_Mutation_p.K609E|GSN_uc010mvt.1_Missense_Mutation_p.K609E|GSN_uc010mvs.1_Missense_Mutation_p.K609E|GSN_uc004ble.1_Missense_Mutation_p.K609E|GSN_uc010mvv.1_Missense_Mutation_p.K609E|GSN_uc011lyh.1_Missense_Mutation_p.K626E|GSN_uc011lyi.1_Missense_Mutation_p.K609E|GSN_uc011lyj.1_Missense_Mutation_p.K633E|GSN_uc004blg.1_Missense_Mutation_p.K391E	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	660	Actin-binding, Ca-sensitive (Potential).				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						GCTGAAGGACAAGAAGATGGA	0.622000													6	25					0	0	0	0
BAT2L1	84726	broad.mit.edu	37	9	134351594	134351594	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr9:134351594G>C	uc004can.3	+	15	4133	c.4078G>C	c.(4078-4080)GAG>CAG	p.E1360Q	BAT2L1_uc010mzj.1_Missense_Mutation_p.E943Q|BAT2L1_uc004cao.3_Missense_Mutation_p.E718Q	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1360							protein binding				0						CAGGTCCCCTGAGCTCTCCTA	0.672000											OREG0019561	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	19					0	0	0	0
PFKFB1	5207	broad.mit.edu	37	X	54971913	54971913	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:54971913G>A	uc004dty.1	-	10	1128	c.1057C>T	c.(1057-1059)CGA>TGA	p.R353*	PFKFB1_uc010nkd.1_Nonsense_Mutation_p.R161*|PFKFB1_uc011mol.1_Nonsense_Mutation_p.R288*	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	353	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						TCTTGGTCTCGCAGTGCAAAT	0.473000													7	19					0	0	0	0
EFNB1	1947	broad.mit.edu	37	X	68058611	68058611	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:68058611G>A	uc004dxd.3	+	2	1060	c.280G>A	c.(280-282)GAC>AAC	p.D94N	EFNB1_uc004dxe.2_Missense_Mutation_p.D94N	NM_004429	NP_004420	P98172	EFNB1_HUMAN	ephrin-B1 precursor	94	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding				0						CACAGTTCTCGACCCCAACGT	0.567000													6	12					0	0	0	0
CYLC1	1538	broad.mit.edu	37	X	83127918	83127918	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:83127918G>C	uc004eei.1	+	4	223	c.202G>C	c.(202-204)GAA>CAA	p.E68Q	CYLC1_uc004eeh.1_Missense_Mutation_p.E67Q	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	68					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						AAAACTAGAAGAAGGCCAGAA	0.343000													3	19					0	0	0	0
LHFPL1	340596	broad.mit.edu	37	X	111874751	111874751	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:111874751G>C	uc004epq.2	-	4	893	c.560C>G	c.(559-561)TCT>TGT	p.S187C	LHFPL1_uc004epp.2_Missense_Mutation_p.S210C|LHFPL1_uc010nqa.2_RNA|LHFPL1_uc010nqb.2_Missense_Mutation_p.S154C	NM_178175	NP_835469	Q86WI0	LHPL1_HUMAN	lipoma HMGIC fusion partner-like 1 precursor	187						integral to membrane					0						AGCAAAGCAAGAGAGCCAGGT	0.512000													21	74					0	0	0	0
RHOXF2B	727940	broad.mit.edu	37	X	119293055	119293055	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:119293055G>T	uc004esl.3	+	2	404	c.214G>T	c.(214-216)GAT>TAT	p.D72Y		NM_001099685	NP_001093155	P0C7M4	RHF2B_HUMAN	Rhox homeobox family, member 2B	72						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGAAGAAAAAGATGGCGGCGG	0.592000													5	55					0.000151284	0.00015716	1	0
ODZ1	10178	broad.mit.edu	37	X	123554626	123554626	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:123554626G>C	uc004euj.2	-	24	4560	c.4496C>G	c.(4495-4497)TCC>TGC	p.S1499C	ODZ1_uc011muj.1_Missense_Mutation_p.S1505C|ODZ1_uc010nqy.2_Missense_Mutation_p.S1506C	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1499	Extracellular (Potential).|NHL 5.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CACTGCTAAGGAGGAAGGGGC	0.463000													22	61					0	0	0	0
GPR50	9248	broad.mit.edu	37	X	150349840	150349840	+	Silent	SNP	C	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:150349840C>G	uc010ntg.1	+	2	1920	c.1785C>G	c.(1783-1785)ACC>ACG	p.T595T		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	595	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TAGTCACTACCAGTACCAATG	0.537000													23	157					0	0	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303720	151303720	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:151303720C>T	uc004ffk.2	-	5	781	c.373G>A	c.(373-375)GAC>AAC	p.D125N	MAGEA10_uc004ffl.2_Missense_Mutation_p.D125N	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	125											0	Acute lymphoblastic leukemia(192;6.56e-05)					GACTCACTGTCTGGCAGGACC	0.502000													47	146					0	0	0	0
DNASE1L1	1774	broad.mit.edu	37	X	153640369	153640369	+	5'Flank	SNP	C	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chrX:153640369C>T	uc004fks.1	-						DNASE1L1_uc004fkt.1_5'Flank|DNASE1L1_uc004fku.1_5'UTR|DNASE1L1_uc004fkv.1_5'UTR|DNASE1L1_uc004fkw.1_5'UTR|TAZ_uc004fkx.2_Intron|TAZ_uc004fky.2_Intron|TAZ_uc004fkz.2_Intron|TAZ_uc004fla.2_Intron|TAZ_uc004flb.2_Intron|TAZ_uc010nuy.2_Intron|TAZ_uc004flc.3_Intron	NM_006730	NP_006721	P49184	DNSL1_HUMAN	deoxyribonuclease I-like 1 precursor						DNA catabolic process	endoplasmic reticulum	DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGGACGCCGCGGCCCCGACC	0.701000											OREG0003602	type=REGULATORY REGION|Gene=DNASE1L1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	14					0	0	0	0
EPHA2	1969	broad.mit.edu	37	1	16475129	16475130	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:16475129_16475130delCA	uc001aya.1	-	3	703_704	c.566_567delTG	c.(565-567)GTGfs	p.V189fs	EPHA2_uc010oca.1_Frame_Shift_Del_p.V189fs	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	189	Extracellular (Potential).|Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	AGAGCAGCGCCACACAGGCACC	0.644													---	---	---							
IRF2BP2	359948	broad.mit.edu	37	1	234743542	234743543	+	Frame_Shift_Ins	INS	-	CC	CC			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr1:234743542_234743543insCC	uc001hwg.2	-	2	1135_1136	c.1104_1105insGG	c.(1102-1107)GGGCCCfs	p.G368fs	IRF2BP2_uc009xfw.2_5'UTR|IRF2BP2_uc001hwf.2_Frame_Shift_Ins_p.G352fs	NM_182972	NP_892017	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	368_369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			ATCTTAGGGGGCCCGACTTCAC	0.520													---	---	---							
Unknown	0	broad.mit.edu	37	10	52467360	52467361	+	IGR	DEL	CA	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:52467360_52467361delCA								SGMS1 (82437 upstream) : ASAH2B (32335 downstream)																							AGCTGATATCcacacacacaca	0.342													---	---	---							
C10orf120	399814	broad.mit.edu	37	10	124457552	124457553	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr10:124457552_124457553insT	uc001lgn.2	-	3	736_737	c.704_705insA	c.(703-705)AACfs	p.N235fs		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	235										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				GTCTTTTTGTGTTTTTTCCCTC	0.371													---	---	---							
C11orf80	79703	broad.mit.edu	37	11	66568153	66568154	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:66568153_66568154delCA	uc001ojf.2	+	7	766_767	c.759_760delCA	c.(757-762)TCCACAfs	p.S253fs	C11orf80_uc001ojg.2_Frame_Shift_Del_p.S19fs|C11orf80_uc001ojh.2_Frame_Shift_Del_p.S19fs|C11orf80_uc001oji.2_Frame_Shift_Del_p.S19fs|C11orf80_uc010rpk.1_Frame_Shift_Del_p.S87fs	NM_024650	NP_078926	Q8N6T0	CK080_HUMAN	hypothetical protein LOC79703	98_99											0						GAATCCTCTCCACAGAGATCTT	0.356													---	---	---							
TECTA	7007	broad.mit.edu	37	11	120979983	120979983	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr11:120979983delC	uc010rzo.1	+	3	262	c.262delC	c.(262-264)CCCfs	p.P88fs		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	88					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGAATCCTTTCCCCTGACAGA	0.488													---	---	---							
RB1	5925	broad.mit.edu	37	13	48881435	48881435	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr13:48881435delG	uc001vcb.2	+	2	323	c.157delG	c.(157-159)GAAfs	p.E53fs	RB1_uc010acs.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	53					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(13)|p.?(3)|p.E53K(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGAAGAAACAGAAGAACCTGA	0.328		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			---	---	---							
ADAM6	8755	broad.mit.edu	37	14	106774086	106774087	+	Splice_Site	INS	-	AGTAATACACGGCA	AGTAATACACGGCA			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr14:106774086_106774087insAGTAATACACGGCA	uc010tyt.1	-	430		c.15674_splice	c.e430+1							Parts of antibodies, mostly variable regions.												0						GCCTCTTGCACGTGTCCTCAGC	0.550													---	---	---							
Unknown	0	broad.mit.edu	37	15	23265335	23265336	+	IGR	INS	-	G	G			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr15:23265335_23265336insG								GOLGA9P (2592 upstream) : HERC2P2 (16929 downstream)																							AGGCAGGAAGAGGGGGCTCCCA	0.639													---	---	---							
Unknown	0	broad.mit.edu	37	15	75541371	75541371	+	IGR	DEL	T	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr15:75541371delT								C15orf39 (36863 upstream) : GOLGA6C (9528 downstream)																							ATATAACGAGTTTTTTTTTTT	0.289													---	---	---							
ENGASE	64772	broad.mit.edu	37	17	77070997	77070998	+	5'Flank	INS	-	A	A			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr17:77070997_77070998insA	uc002jwv.2	+						ENGASE_uc002jwu.1_5'Flank|ENGASE_uc010wtz.1_5'Flank	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase							cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						ccgggccTGCGATTGCCTCTCG	0.366													---	---	---							
PLA2R1	22925	broad.mit.edu	37	2	160826691	160826692	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:160826691_160826692insC	uc002ube.1	-	18	2834_2835	c.2627_2628insG	c.(2626-2628)GGAfs	p.G876fs	PLA2R1_uc010zcp.1_Frame_Shift_Ins_p.G876fs|PLA2R1_uc002ubf.2_Frame_Shift_Ins_p.G876fs	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	876	Extracellular (Potential).|C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CTTCTTGAAGTCCAATCCACCA	0.322													---	---	---							
CASP8	841	broad.mit.edu	37	2	202131502	202131505	+	Frame_Shift_Del	DEL	TTTC	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr2:202131502_202131505delTTTC	uc002uxr.1	+	3	502_505	c.293_296delTTTC	c.(292-297)ATTTCTfs	p.I98fs	CASP8_uc010ftc.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxo.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxp.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxq.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxs.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxt.1_Frame_Shift_Del_p.I157fs|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxw.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxy.1_Frame_Shift_Del_p.I98fs|CASP8_uc002uxx.1_Frame_Shift_Del_p.I98fs|CASP8_uc010ftf.2_Frame_Shift_Del_p.I98fs	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	98_99					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						AGGGCTCAAATTTCTGCCTACAGG	0.495										HNSCC(4;0.00038)			---	---	---							
Unknown	0	broad.mit.edu	37	21	11180762	11180762	+	IGR	DEL	T	-	-	rs146742149		TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr21:11180762delT								BAGE (81825 upstream) : None (None downstream)																							aACTAACTTCTTTTTTTTTTT	0.169													---	---	---							
SREBF2	6721	broad.mit.edu	37	22	42262949	42262951	+	In_Frame_Del	DEL	GCA	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr22:42262949_42262951delGCA	uc003bbi.2	+	2	372_374	c.203_205delGCA	c.(202-207)GGCAGC>GGC	p.S74del	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	74	Gly/Pro/Ser-rich.|Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						ggcagcagtggcagcagcagcag	0.365													---	---	---							
C5orf39	389289	broad.mit.edu	37	5	43040059	43040060	+	Frame_Shift_Ins	INS	-	GAAC	GAAC			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:43040059_43040060insGAAC	uc003jnf.2	-	1	388_389	c.89_90insGTTC	c.(88-90)TCAfs	p.S30fs	C5orf39_uc010ivj.1_RNA|LOC153684_uc003jng.2_5'Flank|LOC153684_uc003jni.2_5'Flank	NM_001014279	NP_001014301	Q3ZCQ2	AX2R_HUMAN	annexin II receptor	30							receptor activity				0						CACGATCTTCTGAACTCACAAT	0.569											OREG0016598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---							
Unknown	0	broad.mit.edu	37	5	157414414	157414421	+	IGR	DEL	CAGCTGCT	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr5:157414414_157414421delCAGCTGCT								CLINT1 (128246 upstream) : EBF1 (708503 downstream)																							CCTCGGCCTGCAGCTGCTCCAGCTCTGC	0.630													---	---	---							
ABCC10	89845	broad.mit.edu	37	6	43400148	43400148	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:43400148delG	uc003ouy.1	+	3	645	c.430delG	c.(430-432)GCTfs	p.A144fs	ABCC10_uc003ouz.1_Frame_Shift_Del_p.A101fs	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	144	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CTTGCTGCCAGCTCCAGCCCT	0.652													---	---	---							
DLL1	28514	broad.mit.edu	37	6	170592567	170592569	+	In_Frame_Del	DEL	CTT	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr6:170592567_170592569delCTT	uc003qxm.2	-	9	2268_2270	c.1798_1800delAAG	c.(1798-1800)AAGdel	p.K600del		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	600	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CTGAGATGTCCTTCTCACGCTGG	0.631													---	---	---							
RAPGEF5	9771	broad.mit.edu	37	7	22259497	22259499	+	In_Frame_Del	DEL	CTC	-	-			TCGA-CQ-5327-01A-01D-1683-08	TCGA-CQ-5327-10A-01D-1683-08									Somatic	Phase_I	Capture				Illumina GAIIx	da19d7bc-9748-4cd4-bd54-4792894838f0	1f1bed30-9b6d-4a36-9a45-5ee31005bd34	g.chr7:22259497_22259499delCTC	uc003svg.2	-	9	836_838	c.523_525delGAG	c.(523-525)GAGdel	p.E175del		NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	Error:Variant_position_missing_in_Q92565_after_alignment					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						GTTCAGACTTCTCCTGTTCTTTT	0.419													---	---	---							
