Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTLL10	254173	broad.mit.edu	37	1	1118394	1118394	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:1118394C>T	uc001acy.2	+	11	1206	c.1055C>T	c.(1054-1056)CCG>CTG	p.P352L	TTLL10_uc010nyg.1_Missense_Mutation_p.P352L|TTLL10_uc001acz.1_Missense_Mutation_p.P279L	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	352	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACAAGACGCCGTTCCGGGGG	0.706000													4	5					0	0	8.12818e-05	0	0
TAS1R1	80835	broad.mit.edu	37	1	6634946	6634947	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:6634946_6634947GG>AA	uc001ant.2	+	3	754_755	c.754_755GG>AA	c.(754-756)GGC>AAC	p.G252N	TAS1R1_uc001anu.2_Intron|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_Missense_Mutation_p.G252N	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	252	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TGCCCAGGTGGGCGATGAGAGG	0.614000													7	14					0	0	6.4e-05	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854245	12854245	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:12854245G>A	uc001auj.1	+	3	572	c.469G>A	c.(469-471)GAA>AAA	p.E157K		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	157											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCCTCAAGGAAATACCCCA	0.493000													42	53					0	0	0.000147903	0	0
Unknown	0	broad.mit.edu	37	1	21752760	21752760	+	RNA	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:21752760C>T	uc001bep.1	-	3		c.216G>A								Homo sapiens cDNA FLJ25572 fis, clone JTH05111.																		ACGTGTTCTTCCTCCAATGAG	0.453000													4	35					0	0	3.59834e-05	0	0
USP48	84196	broad.mit.edu	37	1	22033010	22033010	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:22033010G>A	uc001bfb.2	-	17	2399	c.2161C>T	c.(2161-2163)CCA>TCA	p.P721S	USP48_uc001bfa.2_Missense_Mutation_p.P259S|USP48_uc010odq.1_Missense_Mutation_p.P733S|USP48_uc009vqc.2_Missense_Mutation_p.P655S|USP48_uc001bfc.2_Missense_Mutation_p.P721S|USP48_uc001bfd.1_5'Flank	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	721	DUSP 3.				ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		AACAAATTTGGGAGAGAAGTC	0.378000													32	30					0	0	0.000409698	0	0
EPHB2	2048	broad.mit.edu	37	1	23222924	23222925	+	Missense_Mutation	DNP	CT	TC	TC			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:23222924_23222925CT>TC	uc009vqj.1	+	9	1863_1864	c.1718_1719CT>TC	c.(1717-1719)GCT>GTC	p.A573V	EPHB2_uc001bge.2_Missense_Mutation_p.A574V|EPHB2_uc001bgf.2_Missense_Mutation_p.A573V|EPHB2_uc010odu.1_Intron	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	573	Cytoplasmic (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TTTGAGCGTGCTGACTCGGAGT	0.589000									Hereditary_Prostate_Cancer				7	15					0	0	6.4e-05	0	0
AIM1L	55057	broad.mit.edu	37	1	26669245	26669245	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:26669245C>T	uc001bmd.3	-	4	499	c.69G>A	c.(67-69)TGG>TGA	p.W23*		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	23							sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		ACTCACTCACCCAGACAACCC	0.458000													9	46					0	0	0.000442599	0	0
ST3GAL3	6487	broad.mit.edu	37	1	44386575	44386575	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:44386575C>T	uc001ckc.2	+	11	1190	c.1013C>T	c.(1012-1014)ACC>ATC	p.T338I	ST3GAL3_uc001cjz.2_Missense_Mutation_p.T353I|ST3GAL3_uc001cka.2_Intron|ST3GAL3_uc001ckb.2_Missense_Mutation_p.T407I|ST3GAL3_uc001ckd.2_Missense_Mutation_p.T392I|ST3GAL3_uc001cke.2_Missense_Mutation_p.T322I|ST3GAL3_uc001ckf.2_Missense_Mutation_p.T376I|ST3GAL3_uc001ckg.2_Intron|ST3GAL3_uc001ckh.2_Intron|ST3GAL3_uc001cki.2_Intron|ST3GAL3_uc009vwv.2_Missense_Mutation_p.T308I|ST3GAL3_uc001ckj.2_RNA|ST3GAL3_uc009vww.2_RNA|ST3GAL3_uc001ckk.2_Missense_Mutation_p.T307I|ST3GAL3_uc009vwy.2_Missense_Mutation_p.T244I|ST3GAL3_uc009vwx.2_Intron|ST3GAL3_uc001ckm.2_Intron|ST3GAL3_uc001ckl.2_Intron|ST3GAL3_uc009vwz.2_Missense_Mutation_p.T112I|ST3GAL3_uc001ckn.2_Intron|ST3GAL3_uc001ckp.2_Intron|ST3GAL3_uc001cko.2_Intron|ST3GAL3_uc009vxa.2_Missense_Mutation_p.T125I|ST3GAL3_uc001ckq.2_Intron|ST3GAL3_uc001ckr.2_Intron|ST3GAL3_uc009vxb.2_Intron	NM_006279	NP_006270	Q11203	SIAT6_HUMAN	sialyltransferase 6 isoform j	338	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			ovary(3)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				TACTATGAGACCGTTCGCATG	0.577000													4	3					0	0	0.00024832	0	0
MAST2	23139	broad.mit.edu	37	1	46501426	46501426	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:46501426G>A	uc001cov.2	+	29	5368	c.5085G>A	c.(5083-5085)AAG>AAA	p.K1695K	MAST2_uc001cow.2_Silent_p.K1694K|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	1695					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CCCAGCCTAAGAACCTGTCTC	0.592000													9	12					0	0	0.000442599	0	0
DAB1	1600	broad.mit.edu	37	1	57491659	57491659	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:57491659G>C	uc001cys.1	-	12	1455	c.781C>G	c.(781-783)CCC>GCC	p.P261A	DAB1_uc001cyt.1_Missense_Mutation_p.P259A|DAB1_uc001cyq.1_Missense_Mutation_p.P259A|DAB1_uc001cyr.1_Missense_Mutation_p.P175A|DAB1_uc009vzw.1_Missense_Mutation_p.P243A|DAB1_uc009vzx.1_Missense_Mutation_p.P261A	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	294					cell differentiation|nervous system development					skin(2)|ovary(1)	3						CTTACGGGGGGAGAGGTTATA	0.368000													15	47					0	0	0.000308642	0	0
L1TD1	54596	broad.mit.edu	37	1	62675689	62675689	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:62675689G>A	uc001dae.3	+	4	1545	c.1243G>A	c.(1243-1245)GAG>AAG	p.E415K		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	415	Glu-rich.									ovary(1)|skin(1)	2						agggctggaggaggaagaaga	0.259000													16	10					0	0	0.000422831	0	0
JAK1	3716	broad.mit.edu	37	1	65344732	65344732	+	Missense_Mutation	SNP	G	A	A	rs67657858		TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:65344732G>A	uc001dbu.1	-	4	554	c.305C>T	c.(304-306)TCC>TTC	p.S102F	JAK1_uc009wam.1_Missense_Mutation_p.S90F|JAK1_uc001dbv.2_5'Flank	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	102	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		GAGCCGGAGGGACATCTTGTC	0.552000			Mis		ALL								7	12					0	0	8.12818e-05	0	0
LRRC7	57554	broad.mit.edu	37	1	70541791	70541791	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:70541791C>T	uc001dep.2	+	22	4178	c.4148C>T	c.(4147-4149)TCC>TTC	p.S1383F	LRRC7_uc009wbg.2_Missense_Mutation_p.S667F|LRRC7_uc001deq.2_Missense_Mutation_p.S577F	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1383						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TTGATGGGGTCCCAAAGCCTT	0.478000													7	25					0	0	0.000442599	0	0
CYB561D1	284613	broad.mit.edu	37	1	110038845	110038845	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:110038845C>T	uc010ovn.1	+	3	715	c.654C>T	c.(652-654)TCC>TCT	p.S218S	CYB561D1_uc010ovl.1_Silent_p.S161S|CYB561D1_uc010ovm.1_Silent_p.S160S|CYB561D1_uc001dxu.2_3'UTR|CYB561D1_uc001dxw.2_3'UTR|CYB561D1_uc010ovo.1_Silent_p.S240S|CYB561D1_uc009wfd.2_Silent_p.S167S|CYB561D1_uc010ovp.1_Silent_p.S152S	NM_182580	NP_872386	Q8N8Q1	C56D1_HUMAN	cytochrome b-561 domain containing 1 isoform 2	218	Cytochrome b561.|Cytoplasmic (Potential).				electron transport chain|transport	integral to membrane	metal ion binding				0		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0422)|Epithelial(280;0.0655)|all cancers(265;0.0685)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		ACCAGATTTCCAGATCCTACT	0.527000													15	32					0	0	0.000308642	0	0
HMGCS2	3158	broad.mit.edu	37	1	120301885	120301885	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:120301885C>G	uc001eid.2	-	4	757	c.706G>C	c.(706-708)GAG>CAG	p.E236Q	HMGCS2_uc010oxj.1_Missense_Mutation_p.E194Q|HMGCS2_uc001eie.2_Missense_Mutation_p.E144Q	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	236					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		TACACATTCTCCATATGGGTT	0.473000													4	144					0	0	0.000602214	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144864154	144864155	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:144864154_144864155GG>TT	uc001elw.3	-	36	6231_6232	c.5940_5941CC>AA	c.(5938-5943)TCCCTC>TCAATC	p.L1981I	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.L1875I|PDE4DIP_uc001elv.3_Missense_Mutation_p.L988I|PDE4DIP_uc001ema.2_Missense_Mutation_p.L168I	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1981	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTTTCCTGGAGGGAAAGACGTT	0.441000			T	PDGFRB	MPD								10	217					0	0	6.4e-05	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	G	G	rs9424867		TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													3	24					0	0	3.59834e-05	0	0
EFNA4	1945	broad.mit.edu	37	1	155041374	155041374	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:155041374C>T	uc001fhd.2	+	4	602	c.515C>T	c.(514-516)ACA>ATA	p.T172I	EFNA3_uc010pew.1_Intron|EFNA4_uc001fhc.2_Intron|EFNA4_uc001fhe.2_Intron	NM_005227	NP_005218	P52798	EFNA4_HUMAN	ephrin A4 isoform a	172					cell-cell signaling	anchored to membrane|extracellular region|integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity				0	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GAGAGTGGCACATCAGGGTGG	0.577000													4	9					0	0	0.00024832	0	0
OR10J3	441911	broad.mit.edu	37	1	159283771	159283771	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:159283771G>A	uc010piu.1	-	1	679	c.679C>T	c.(679-681)CTT>TTT	p.L227F		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					GCAATCTTAAGAATGGTGGAG	0.488000													9	34					0	0	0.000442599	0	0
SLAMF1	6504	broad.mit.edu	37	1	160604530	160604530	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:160604530G>A	uc001fwl.3	-	3	919	c.573C>T	c.(571-573)TCC>TCT	p.S191S	SLAMF1_uc010pjk.1_RNA|SLAMF1_uc010pjl.1_RNA|SLAMF1_uc010pjm.1_RNA	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	191	Ig-like C2-type.|Extracellular (Potential).|Ig-like V-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ACAGGAGGTGGGAGCTGTTGG	0.587000													14	20					0	0	0.000422831	0	0
KIF21B	23046	broad.mit.edu	37	1	200974494	200974494	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:200974494G>A	uc001gvs.1	-	5	991	c.674C>T	c.(673-675)TCC>TTC	p.S225F	KIF21B_uc001gvr.1_Missense_Mutation_p.S225F|KIF21B_uc009wzl.1_Missense_Mutation_p.S225F|KIF21B_uc010ppn.1_Missense_Mutation_p.S225F|KIF21B_uc001gvt.1_Missense_Mutation_p.S8F	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	225	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GATGGCGTGGGAGCGTGAGCT	0.642000													13	14					0	0	0.000422831	0	0
SLC26A9	115019	broad.mit.edu	37	1	205904882	205904882	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:205904882C>T	uc001hdq.2	-	2	181	c.67G>A	c.(67-69)GAG>AAG	p.E23K	SLC26A9_uc001hdp.2_Missense_Mutation_p.E23K	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	23						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TTCTCAAACTCATCGTCGAAG	0.552000													15	53					0	0	0.000422831	0	0
USH2A	7399	broad.mit.edu	37	1	215987101	215987101	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:215987101C>T	uc001hku.1	-	49	10103	c.9716G>A	c.(9715-9717)GGG>GAG	p.G3239E		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3239	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGCGTAATACCCAGAGCAGCA	0.423000										HNSCC(13;0.011)			5	22					0	0	0.000602214	0	0
CHML	1122	broad.mit.edu	37	1	241797475	241797475	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:241797475G>A	uc001hzd.2	-	1	1758	c.1594C>T	c.(1594-1596)CCG>TCG	p.P532S	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	532					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TCAGTATACGGAGTGAATAAT	0.383000													5	34					0	0	0.000602214	0	0
CNST	163882	broad.mit.edu	37	1	246810825	246810825	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:246810825G>A	uc001ibp.2	+	9	1700	c.1322G>A	c.(1321-1323)CGT>CAT	p.R441H	CNST_uc001ibo.3_Missense_Mutation_p.R441H	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	441					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						GGCTGTGACCGTATACCTCCT	0.502000											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	68					0	0	0.000147903	0	0
ZNF496	84838	broad.mit.edu	37	1	247464421	247464421	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:247464421G>A	uc001ico.2	-	9	1629	c.1164C>T	c.(1162-1164)TCC>TCT	p.S388S	ZNF496_uc009xgv.2_Silent_p.S424S|ZNF496_uc001icp.2_Silent_p.S388S	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	388					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			TGCTCCGGTGGGAGGCGGGGA	0.632000													6	18					0	0	3.59834e-05	0	0
OR2M1P	388762	broad.mit.edu	37	1	248285733	248285733	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr1:248285733C>T	uc001idy.1	+	1	296	c.296C>T	c.(295-297)TCC>TTC	p.S99F		NR_002141				RecName: Full=Olfactory receptor 2M5;												0						TTTTCCTTCTCCTACTGTGGG	0.418000													10	75					0	0	0.000673444	0	0
NEBL	10529	broad.mit.edu	37	10	21141545	21141545	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:21141545C>T	uc001iqi.2	-	10	1334	c.937G>A	c.(937-939)GGA>AGA	p.G313R	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	313	Nebulin 8.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TGATACATTCCTTTGTTTTCC	0.398000													10	4					0	0	0.000219431	0	0
PCDH15	65217	broad.mit.edu	37	10	55913032	55913032	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:55913032C>T	uc001jju.1	-	14	2007	c.1612G>A	c.(1612-1614)GAA>AAA	p.E538K	PCDH15_uc010qhq.1_Missense_Mutation_p.E543K|PCDH15_uc010qhr.1_Missense_Mutation_p.E538K|PCDH15_uc010qhs.1_Missense_Mutation_p.E550K|PCDH15_uc010qht.1_Missense_Mutation_p.E545K|PCDH15_uc010qhu.1_Missense_Mutation_p.E538K|PCDH15_uc001jjv.1_Missense_Mutation_p.E516K|PCDH15_uc010qhv.1_Missense_Mutation_p.E538K|PCDH15_uc010qhw.1_Missense_Mutation_p.E501K|PCDH15_uc010qhx.1_Missense_Mutation_p.E538K|PCDH15_uc010qhy.1_Missense_Mutation_p.E543K|PCDH15_uc010qhz.1_Missense_Mutation_p.E538K|PCDH15_uc010qia.1_Missense_Mutation_p.E516K|PCDH15_uc010qib.1_Missense_Mutation_p.E516K|PCDH15_uc001jjw.2_Missense_Mutation_p.E538K	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	538	Cadherin 5.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTTGACCCTTCGTCTGCGTCG	0.458000										HNSCC(58;0.16)			4	12					0	0	0.000602214	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72462080	72462080	+	Missense_Mutation	SNP	C	T	T	rs34022601	byFrequency	TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:72462080C>T	uc001jrh.2	+	3	535	c.535C>T	c.(535-537)CGC>TGC	p.R179C	ADAMTS14_uc001jrg.2_Missense_Mutation_p.R179C	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	179					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						GGGCCTCATCCGCACAGACAG	0.607000													11	19					0	0	0.00010058	0	0
NDST2	8509	broad.mit.edu	37	10	75567585	75567585	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:75567585G>A	uc001jvk.2	-	3	1366	c.562C>T	c.(562-564)CCC>TCC	p.P188S	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Missense_Mutation_p.P65S|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_Missense_Mutation_p.P65S	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	188	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					AAAAAAAGGGGAAAGCCCTTG	0.582000													6	11					0	0	3.59834e-05	0	0
MYST4	23522	broad.mit.edu	37	10	76784907	76784908	+	Silent	DNP	CC	TT	TT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:76784907_76784908CC>TT	uc001jwn.1	+	17	4057_4058	c.3564_3565CC>TT	c.(3562-3567)GTCCTG>GTTTTG	p.1188_1189VL>VL	MYST4_uc001jwo.1_Silent_p.896_897VL>VL|MYST4_uc001jwp.1_Silent_p.1005_1006VL>VL	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1188_1189					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					GGAAGCCAGTCCTGAGAAAAGC	0.475000			T	CREBBP	AML								8	14					0	0	6.4e-05	0	0
MYOF	26509	broad.mit.edu	37	10	95116542	95116542	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:95116542G>A	uc001kin.2	-	30	3307	c.3184C>T	c.(3184-3186)CAC>TAC	p.H1062Y	MYOF_uc001kio.2_Missense_Mutation_p.H1049Y|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1062	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						TGTTTCCAGTGAAATTTCCAG	0.418000													9	28					0	0	0.000442599	0	0
GPR120	338557	broad.mit.edu	37	10	95335922	95335922	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:95335922G>A	uc010qnt.1	+	2	698	c.642G>A	c.(640-642)TTG>TTA	p.L214L	GPR120_uc010qnu.1_Silent_p.L214L	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	G protein-coupled receptor 120	214	Helical; Name=5; (Potential).				negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding				0		Colorectal(252;0.122)				TTGTTACTTTGAACTTCTTGG	0.433000													18	55					0	0	0.000132079	0	0
VWA2	340706	broad.mit.edu	37	10	116045904	116045904	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:116045904G>A	uc001lbl.1	+	11	1525	c.1204G>A	c.(1204-1206)GAT>AAT	p.D402N	VWA2_uc001lbk.1_Missense_Mutation_p.D402N|VWA2_uc009xyf.1_Missense_Mutation_p.D98N	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	402	VWFA 2.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		GGAGTACCAGGATGTGCCTGA	0.682000													11	16					0	0	0.00010058	0	0
SLC18A2	6571	broad.mit.edu	37	10	119027222	119027222	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:119027222G>A	uc001ldd.1	+	13	1192	c.1161G>A	c.(1159-1161)CCG>CCA	p.P387P	SLC18A2_uc009xyy.1_Silent_p.P184P	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	387	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TCATAGCTCCGAACTTTGGAG	0.383000													9	22					0	0	0.00010058	0	0
DMBT1	1755	broad.mit.edu	37	10	124358388	124358388	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:124358388G>A	uc001lgk.1	+	26	3161	c.3055G>A	c.(3055-3057)GAT>AAT	p.D1019N	DMBT1_uc001lgl.1_Missense_Mutation_p.D1009N|DMBT1_uc001lgm.1_Missense_Mutation_p.D520N|DMBT1_uc009xzz.1_Missense_Mutation_p.D1019N|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_5'UTR	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1019	SRCR 8.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CACCGTGTGCGATGACAGCTG	0.602000													29	60					0	0	0.00058488	0	0
ADAM12	8038	broad.mit.edu	37	10	127708368	127708368	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:127708368C>T	uc001ljk.2	-	22	2978	c.2565G>A	c.(2563-2565)CAG>CAA	p.Q855Q	ADAM12_uc010qul.1_Silent_p.Q806Q	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	855	Cytoplasmic (Potential).				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GCAGAGGCTTCTGAGGGGGGT	0.622000													3	4					0	0	6.4e-05	0	0
PWWP2B	170394	broad.mit.edu	37	10	134219629	134219629	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr10:134219629C>T	uc001lll.3	+	2	1654	c.1625C>T	c.(1624-1626)TCA>TTA	p.S542L	PWWP2B_uc009ybe.2_Intron	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	542	PWWP.										0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		TTGTCTATTTCAAAACTCTCC	0.478000													9	25					0	0	0.000442599	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1629423	1629423	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:1629423C>T	uc001ltw.1	-	1	271	c.193G>A	c.(193-195)GGG>AGG	p.G65R		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	65	11 X 4 AA repeats of C-C-X-P.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		CCACAGACCCCCTTGGAGCCC	0.672000													15	34					0	0	0.000422831	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5664422	5664422	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:5664422C>T	uc001mbf.2	+	14	2256	c.2012C>T	c.(2011-2013)TCA>TTA	p.S671L	HBG2_uc001mak.1_Intron|TRIM34_uc001mbh.2_Missense_Mutation_p.S317L|TRIM34_uc009yeq.2_Missense_Mutation_p.S72L|TRIM34_uc001mbi.2_Missense_Mutation_p.S317L|TRIM78P_uc009yer.2_RNA	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	671						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		CTTGTCCTTTCAGAAGATCAG	0.323000													8	13					0	0	0.000274275	0	0
OR5P3	120066	broad.mit.edu	37	11	7847104	7847104	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:7847104C>T	uc010rbg.1	-	1	416	c.416G>A	c.(415-417)GGA>GAA	p.G139E		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GATGCAGACTCCAGGGGACAT	0.532000													16	20					0	0	9.7654e-05	0	0
OR10A6	390093	broad.mit.edu	37	11	7949332	7949332	+	Missense_Mutation	SNP	C	T	T	rs143603778		TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:7949332C>T	uc010rbh.1	-	1	878	c.878G>A	c.(877-879)CGA>CAA	p.R293Q		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTCACTATTTCGCAAACTGTA	0.418000													16	32					0	0	0.000566183	0	0
AMPD3	272	broad.mit.edu	37	11	10483082	10483082	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:10483082C>T	uc001mio.1	+	2	351	c.16C>T	c.(16-18)CCC>TCC	p.P6S	AMPD3_uc010rbz.1_5'UTR|AMPD3_uc001min.1_Missense_Mutation_p.P15S|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Missense_Mutation_p.P6S|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.P13S|AMPD3_uc009yfy.2_Missense_Mutation_p.P6S	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	6					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		GCGGCAGTTTCCCAAGCTGAA	0.542000													35	60					0	0	0.000270559	0	0
MICALCL	84953	broad.mit.edu	37	11	12315206	12315206	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:12315206G>A	uc001mkg.1	+	3	519	c.228G>A	c.(226-228)AGG>AGA	p.R76R		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	76	Interaction with MAPK1 (By similarity).				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		GAGCACCCAGGGAAATTCCCC	0.582000													21	50					0	0	0.000586117	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17153471	17153472	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:17153471_17153472CC>AA	uc001mmq.3	-	11	2288_2289	c.2222_2223GG>TT	c.(2221-2223)TGG>TTT	p.W741F	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.W361F|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	741					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	ACAGTTCATCCCATTTAATAAG	0.312000													9	180					0	0	6.4e-05	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137497	40137497	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:40137497C>T	uc001mxa.1	-	2	2310	c.346G>A	c.(346-348)GAA>AAA	p.E116K	LRRC4C_uc001mxc.1_Missense_Mutation_p.E112K|LRRC4C_uc001mxd.1_Missense_Mutation_p.E112K|LRRC4C_uc001mxb.1_Missense_Mutation_p.E112K	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	116	LRR 2.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GCCCCAATTTCAATGGTTCTG	0.428000													7	22					0	0	0.000274275	0	0
GYLTL1B	120071	broad.mit.edu	37	11	45949026	45949026	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:45949026G>A	uc001nbv.1	+	11	1597	c.1486G>A	c.(1486-1488)GGG>AGG	p.G496R	GYLTL1B_uc001nbw.1_Missense_Mutation_p.G465R|GYLTL1B_uc001nbx.1_Missense_Mutation_p.G496R|GYLTL1B_uc001nby.1_Missense_Mutation_p.G179R|GYLTL1B_uc001nbz.1_5'Flank	NM_152312	NP_689525	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	496	Lumenal (Potential).				muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.226)		GTACCGTGAGGGGCCCCTATA	0.607000													22	30					0	0	0.000295444	0	0
OR4S1	256148	broad.mit.edu	37	11	48328285	48328285	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:48328285G>A	uc010rhu.1	+	1	511	c.511G>A	c.(511-513)GAG>AAG	p.E171K		NM_001004725	NP_001004725	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGGGCCCAATGAGATAGACAA	0.552000													17	26					0	0	0.000566183	0	0
OR8K3	219473	broad.mit.edu	37	11	56086116	56086116	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:56086116C>T	uc010rjf.1	+	1	334	c.334C>T	c.(334-336)CTT>TTT	p.L112F		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TGGTAGTGAACTTTTTATTCT	0.378000													30	52					0	0	0.000409698	0	0
CTNND1	1500	broad.mit.edu	37	11	57569667	57569668	+	Nonsense_Mutation	DNP	CG	AT	AT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:57569667_57569668CG>AT	uc001nmc.3	+	7	1990_1991	c.1419_1420CG>AT	c.(1417-1422)ACCGGA>ACATGA	p.G474*	CTNND1_uc001nlh.1_Nonsense_Mutation_p.G474*|CTNND1_uc001nlu.3_Nonsense_Mutation_p.G373*|CTNND1_uc001nlt.3_Nonsense_Mutation_p.G373*|CTNND1_uc001nls.3_Nonsense_Mutation_p.G373*|CTNND1_uc001nlw.3_Nonsense_Mutation_p.G373*|CTNND1_uc001nmf.3_Nonsense_Mutation_p.G474*|CTNND1_uc001nmd.3_Nonsense_Mutation_p.G420*|CTNND1_uc001nlk.3_Nonsense_Mutation_p.G420*|CTNND1_uc001nme.3_Nonsense_Mutation_p.G474*|CTNND1_uc001nll.3_Nonsense_Mutation_p.G420*|CTNND1_uc001nmg.3_Nonsense_Mutation_p.G420*|CTNND1_uc001nlj.3_Nonsense_Mutation_p.G420*|CTNND1_uc001nlr.3_Nonsense_Mutation_p.G420*|CTNND1_uc001nlp.3_Nonsense_Mutation_p.G420*|CTNND1_uc001nlx.3_Nonsense_Mutation_p.G151*|CTNND1_uc001nlz.3_Nonsense_Mutation_p.G151*|CTNND1_uc009ymn.2_Nonsense_Mutation_p.G151*|CTNND1_uc001nlm.3_Nonsense_Mutation_p.G474*|CTNND1_uc001nly.3_Nonsense_Mutation_p.G151*|CTNND1_uc001nmb.3_Nonsense_Mutation_p.G151*|CTNND1_uc001nma.3_Nonsense_Mutation_p.G151*|CTNND1_uc001nmi.3_Nonsense_Mutation_p.G373*|CTNND1_uc001nmh.3_Nonsense_Mutation_p.G474*|CTNND1_uc001nlq.3_Nonsense_Mutation_p.G373*|CTNND1_uc001nln.3_Nonsense_Mutation_p.G474*|CTNND1_uc001nli.3_Nonsense_Mutation_p.G474*|CTNND1_uc001nlo.3_Nonsense_Mutation_p.G373*|CTNND1_uc001nlv.3_Nonsense_Mutation_p.G373*	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	474	ARM 3.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				AAGTTATTACCGGTGAGTTCTA	0.411000													7	144					0	0	6.4e-05	0	0
OR5B12	390191	broad.mit.edu	37	11	58207358	58207358	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:58207358G>A	uc010rkh.1	-	1	267	c.267C>T	c.(265-267)TTC>TTT	p.F89F		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TATATAATATGAATTTGTCTC	0.453000													5	12					0	0	3.59834e-05	0	0
MS4A12	54860	broad.mit.edu	37	11	60265037	60265037	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:60265037G>A	uc001npr.2	+	2	303	c.246G>A	c.(244-246)ATG>ATA	p.M82I	MS4A12_uc009ynb.2_Missense_Mutation_p.M82I	NM_017716	NP_060186	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member	82	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						CAGCAGTAATGAACTTTAAAG	0.393000													11	19					0	0	0.000673444	0	0
SLC22A6	9356	broad.mit.edu	37	11	62751136	62751136	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:62751136C>T	uc001nwk.2	-	3	808	c.501G>A	c.(499-501)TTG>TTA	p.L167L	SLC22A6_uc001nwl.2_Silent_p.L167L|SLC22A6_uc001nwj.2_Silent_p.L167L|SLC22A6_uc001nwm.2_Silent_p.L167L	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	167	Helical; (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						GCAGGTAGTTCAAGATGAGTA	0.637000													6	14					0	0	0.000157383	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64699325	64699325	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:64699325C>T	uc001oby.2	+	11	1686	c.1101C>T	c.(1099-1101)TCC>TCT	p.S367S	PPP2R5B_uc001obz.2_Silent_p.S367S	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	367					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						GCTGTGTTTCCAGCCCCCATT	0.552000													15	22					0	0	0.000175454	0	0
FRMD8	83786	broad.mit.edu	37	11	65161522	65161522	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:65161522C>T	uc001odu.3	+	5	558	c.366C>T	c.(364-366)TTC>TTT	p.F122F	FRMD8_uc009yqj.2_Silent_p.F66F|FRMD8_uc010rof.1_Silent_p.F88F	NM_031904	NP_114110	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	122	FERM.					cytoskeleton	binding			lung(1)|pancreas(1)	2						ATGAGCCTTTCCTGCAGTTCC	0.672000													5	9					0	0	0.000602214	0	0
NPAS4	266743	broad.mit.edu	37	11	66192030	66192030	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:66192030C>T	uc001ohx.1	+	7	1845	c.1669C>T	c.(1669-1671)CCT>TCT	p.P557S	NPAS4_uc010rpc.1_Missense_Mutation_p.P347S	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	557					transcription, DNA-dependent		DNA binding|signal transducer activity				0						GAGCCCCAACCCTACCAAGAC	0.582000													14	46					0	0	0.000151284	0	0
SYT12	91683	broad.mit.edu	37	11	66807332	66807333	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:66807332_66807333CC>TT	uc009yrl.2	+	4	509_510	c.279_280CC>TT	c.(277-282)AGCCGC>AGTTGC	p.R94C	SYT12_uc001oju.2_Missense_Mutation_p.R94C	NM_177963	NP_808878	Q8IV01	SYT12_HUMAN	synaptotagmin XII	94	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane				ovary(1)	1						GACCACCCAGCCGCAAAGGCAG	0.634000													18	31					0	0	6.4e-05	0	0
FCHSD2	9873	broad.mit.edu	37	11	72726930	72726931	+	Splice_Site	DNP	CC	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:72726930_72726931CC>AA	uc009ytl.2	-	4	387	c.166_splice	c.e4-1	p.G56_splice	FCHSD2_uc010rrg.1_Splice_Site|FCHSD2_uc001oth.3_Splice_Site|FCHSD2_uc001oti.2_Splice_Site_p.G15_splice	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2								protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			TTCTGCATACCCTGttaaaaaa	0.302000													15	360					0	0	6.4e-05	0	0
ODZ4	26011	broad.mit.edu	37	11	78413143	78413143	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:78413143G>A	uc001ozl.3	-	28	4978	c.4515C>T	c.(4513-4515)CTC>CTT	p.L1505L	ODZ4_uc009yvb.1_Silent_p.L89L	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1505	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CCCCAGCAACGAGTGAGATCT	0.473000													11	11					0	0	0.000673444	0	0
FAT3	120114	broad.mit.edu	37	11	92533086	92533087	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:92533086_92533087GG>TT	uc001pdj.3	+	9	6924_6925	c.6907_6908GG>TT	c.(6907-6909)GGG>TTG	p.G2303L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2303	Cadherin 21.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATCTCTTATTGGGACACCTGTT	0.366000										TCGA Ovarian(4;0.039)			11	369					0	0	6.4e-05	0	0
FAT3	120114	broad.mit.edu	37	11	92592472	92592473	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:92592472_92592473CC>AA	uc001pdj.3	+	20	11659_11660	c.11642_11643CC>AA	c.(11641-11643)CCC>CAA	p.P3881Q	FAT3_uc001pdi.3_Missense_Mutation_p.P321Q	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3881	Laminin G-like.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGAGCAAATCCCTGCATAATTC	0.391000										TCGA Ovarian(4;0.039)			8	177					0	0	6.4e-05	0	0
HEPHL1	341208	broad.mit.edu	37	11	93837781	93837781	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:93837781G>A	uc001pep.2	+	16	2927	c.2770G>A	c.(2770-2772)GAA>AAA	p.E924K	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	924	Extracellular (Potential).|Plastocyanin-like 6.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CGTTGATTATGAATTTGCTCT	0.363000													46	50					0	0	0.000147903	0	0
DRD2	1813	broad.mit.edu	37	11	113283578	113283578	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:113283578C>T	uc001pnz.2	-	6	1159	c.838G>A	c.(838-840)GAG>AAG	p.E280K	DRD2_uc010rwv.1_Missense_Mutation_p.E279K|DRD2_uc001poa.3_Missense_Mutation_p.E280K|DRD2_uc001pob.3_Missense_Mutation_p.E251K	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	280	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	ATCTCCATCTCCAGCTCCTGG	0.672000													6	9					0	0	3.59834e-05	0	0
USP2	9099	broad.mit.edu	37	11	119229734	119229735	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:119229734_119229735GG>AA	uc001pwm.3	-	6	1466_1467	c.1171_1172CC>TT	c.(1171-1173)CCT>TTT	p.P391F	USP2_uc001pwl.3_Missense_Mutation_p.P182F|USP2_uc001pwn.3_Missense_Mutation_p.P148F	NM_004205	NP_004196	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2 isoform a	391					cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			ovary(2)|urinary_tract(1)|skin(1)	4		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		TCTTACTTACGGAAGATGATCG	0.450000													15	19					0	0	6.4e-05	0	0
THY1	7070	broad.mit.edu	37	11	119290151	119290151	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:119290151G>A	uc001pwq.2	-	3	487	c.453C>T	c.(451-453)TCC>TCT	p.S151S	uc001pwo.2_Intron|uc001pwp.1_Intron|THY1_uc001pwr.2_Silent_p.S151S|THY1_uc001pws.2_RNA	NM_006288	NP_006279	P04216	THY1_HUMAN	Thy-1 cell surface antigen preproprotein	151					angiogenesis|cell-cell adhesion|cytoskeleton organization|focal adhesion assembly|negative regulation of axonogenesis|negative regulation of cell migration|negative regulation of protein kinase activity|negative regulation of T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell activation|retinal cone cell development|T cell receptor signaling pathway	endoplasmic reticulum|growth cone|integral to plasma membrane|membrane raft	GPI anchor binding|integrin binding|Rho GTPase activator activity				0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.83e-05)		CCTGGAGGAGGGAGAGGGAGA	0.587000													11	18					0	0	6.40141e-05	0	0
OR10G4	390264	broad.mit.edu	37	11	123887086	123887086	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:123887086G>A	uc010sac.1	+	1	805	c.805G>A	c.(805-807)GGA>AGA	p.G269R		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	269	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TGCCATGGATGGAGTTGTGGC	0.493000													20	26					0	0	0.000175454	0	0
HEPN1	641654	broad.mit.edu	37	11	124789780	124789780	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr11:124789780C>T	uc001qbj.1	+	1	635	c.134C>T	c.(133-135)TCT>TTT	p.S45F	HEPACAM_uc009zbj.2_3'UTR|HEPACAM_uc001qbk.2_3'UTR	NM_001037558	NP_001032647	Q6WQI6	HEPN1_HUMAN	HEPACAM opposite strand 1	45						cytoplasm					0	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0287)		GCCTCCTTCTCTTTCAGCTTT	0.502000													15	11					0	0	0.000308642	0	0
C12orf53	196500	broad.mit.edu	37	12	6804720	6804720	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:6804720C>T	uc001qqf.1	-	5	779	c.703G>A	c.(703-705)GGA>AGA	p.G235R	C12orf53_uc001qqg.1_Missense_Mutation_p.G235R	NM_153685	NP_710152	Q8IYJ0	CL053_HUMAN	hypothetical protein LOC196500 precursor	235	Cytoplasmic (Potential).					integral to membrane					0						ACAGTGACTCCAGCCGGGGAC	0.701000													6	21					0	0	3.59834e-05	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716619	13716619	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:13716619C>T	uc001rbt.2	-	13	3732	c.3553G>A	c.(3553-3555)GAC>AAC	p.D1185N		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1185	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCGTGTTTGTCGCCCGTCCCG	0.622000													9	14					0	0	6.40141e-05	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717242	13717242	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:13717242T>A	uc001rbt.2	-	13	3109	c.2930A>T	c.(2929-2931)GAC>GTC	p.D977V		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	977	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CACGTTGCTGTCCTTCAGCTG	0.542000													16	19					0	0	0.000422831	0	0
PLCZ1	89869	broad.mit.edu	37	12	18847964	18847964	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:18847964C>T	uc010sid.1	-	12	1532	c.1341G>A	c.(1339-1341)GGG>GGA	p.G447G	PLCZ1_uc001rdv.3_Silent_p.G343G|PLCZ1_uc001rdw.3_Silent_p.G188G|PLCZ1_uc001rdu.1_Silent_p.G229G|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	447	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CCAAAAATTTCCCATTTTGCA	0.348000													14	24					0	0	0.000219431	0	0
PRPF40B	25766	broad.mit.edu	37	12	50025232	50025232	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:50025232C>T	uc001rur.1	+	2	131	c.67C>T	c.(67-69)CCC>TCC	p.P23S	PRPF40B_uc001rup.1_Missense_Mutation_p.P45S|PRPF40B_uc001ruq.1_Missense_Mutation_p.P17S|PRPF40B_uc001rus.1_5'Flank	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	23	Pro-rich.				mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GGGGCTACCCCCCATGAGTCA	0.592000													7	27					0	0	0.000157383	0	0
MIP	4284	broad.mit.edu	37	12	56847477	56847477	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:56847477G>A	uc001slh.2	-	2	455	c.423C>T	c.(421-423)TTC>TTT	p.F141F		NM_012064	NP_036196	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	141	Helical; (By similarity).				response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			skin(1)	1						TGCAGAGCACGAACTGGAGCG	0.607000													6	10					0	0	3.59834e-05	0	0
LRIG3	121227	broad.mit.edu	37	12	59266385	59266385	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:59266385G>A	uc001sqr.2	-	19	3575	c.3329C>T	c.(3328-3330)CCA>CTA	p.P1110L	LRIG3_uc009zqh.2_Missense_Mutation_p.P1050L|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	1110						integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			CTGAAAATTTGGAGTCCTGTA	0.358000													29	23					0	0	0.000117367	0	0
PPFIA2	8499	broad.mit.edu	37	12	81688696	81688696	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:81688696G>A	uc001szo.1	-	24	3004	c.2843C>T	c.(2842-2844)CCA>CTA	p.P948L	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	874										ovary(3)|lung(2)|pancreas(1)	6						GCGATGCAGTGGATTGCTGAT	0.493000													6	11					0	0	3.59834e-05	0	0
C12orf63	374467	broad.mit.edu	37	12	97136223	97136223	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:97136223G>A	uc001tet.1	+	19	2431	c.2353G>A	c.(2353-2355)GAA>AAA	p.E785K		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	785										skin(6)|ovary(1)	7						TTAGGTCACTGAAAATAAAGA	0.348000													13	20					0	0	0.000308642	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640542	99640542	+	Silent	SNP	A	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:99640542A>G	uc001tge.1	-	13	2274	c.1857T>C	c.(1855-1857)CCT>CCC	p.P619P	ANKS1B_uc001tgf.1_Silent_p.P199P|ANKS1B_uc001tgk.2_5'UTR|ANKS1B_uc009ztt.1_Silent_p.P585P	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	619						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		ATGGATTTTCAGGGGACTCAC	0.463000													4	89					0	0	3.59834e-05	0	0
UTP20	27340	broad.mit.edu	37	12	101755832	101755832	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:101755832G>A	uc001tia.1	+	44	5940	c.5784G>A	c.(5782-5784)ATG>ATA	p.M1928I		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1928					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TAGATATAATGATTGAGGTAA	0.378000													30	45					0	0	0.000279167	0	0
ATP2A2	488	broad.mit.edu	37	12	110760812	110760812	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:110760812C>T	uc001tqk.3	+	6	1042	c.479C>T	c.(478-480)CCT>CTT	p.P160L	ATP2A2_uc001tql.3_Missense_Mutation_p.P160L|ATP2A2_uc010sxy.1_Intron	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	160	Cytoplasmic (By similarity).		P -> L (in DD).		ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						GACAAAGTTCCTGCTGATATA	0.318000													27	43					0	0	0.000227799	0	0
ALDH2	217	broad.mit.edu	37	12	112221087	112221087	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:112221087C>T	uc001tst.2	+	3	786	c.345C>T	c.(343-345)GAC>GAT	p.D115D	ALDH2_uc010syi.1_Intron|ALDH2_uc009zvy.2_Silent_p.D115D	NM_000690	NP_000681	P05091	ALDH2_HUMAN	mitochondrial aldehyde dehydrogenase 2	115					carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase|electron carrier activity			skin(2)|ovary(1)|central_nervous_system(1)	4					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)	TCGAGCGGGACCGGACCTACC	0.662000			T	HMGA2	leiomyoma								5	23					0	0	0.000602214	0	0
TPCN1	53373	broad.mit.edu	37	12	113724876	113724876	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:113724876C>T	uc001tuw.2	+	19	1908	c.1611C>T	c.(1609-1611)GTC>GTT	p.V537V	TPCN1_uc001tux.2_Silent_p.V609V|TPCN1_uc010syt.1_Silent_p.V469V	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	537	Helical; Name=S4 of repeat II; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						TCATCGTGGTCCTGCGCCCCC	0.612000													8	24					0	0	0.000274275	0	0
KSR2	283455	broad.mit.edu	37	12	117993065	117993065	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr12:117993065G>A	uc001two.2	-	9	1395	c.1340C>T	c.(1339-1341)CCG>CTG	p.P447L		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	476					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GATGTCACACGGAACGGACTC	0.488000													5	6					0	0	3.59834e-05	0	0
SACS	26278	broad.mit.edu	37	13	23915544	23915544	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr13:23915544G>A	uc001uon.2	-	10	3060	c.2471C>T	c.(2470-2472)TCG>TTG	p.S824L	SACS_uc001uoo.2_Missense_Mutation_p.S677L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	824				QTCVELIRLRIPSLVILDDES -> FLFDEDSNGKLKMVAV LITSC (in Ref. 3; CAE45964).	cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AATGACTAACGATGGAATCCT	0.383000													29	47					0	0	0.000339439	0	0
SPATA13	221178	broad.mit.edu	37	13	24823957	24823957	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr13:24823957G>A	uc001upg.1	+	2	528	c.121G>A	c.(121-123)GAA>AAA	p.E41K	SPATA13_uc001upd.1_Missense_Mutation_p.E666K|C1QTNF9_uc001upe.2_Intron|SPATA13_uc010tcy.1_5'Flank|SPATA13_uc010tcz.1_5'Flank	NM_153023	NP_694568	Q96N96	SPT13_HUMAN	spermatogenesis associated 13	41					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		CCAGACGGAGGAACTGGACAA	0.567000													13	16					0	0	0.000308642	0	0
BRCA2	675	broad.mit.edu	37	13	32893249	32893249	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr13:32893249C>T	uc001uub.1	+	3	330	c.103C>T	c.(103-105)CTT>TTT	p.L35F	BRCA2_uc001uua.1_5'UTR	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	35	Interaction with PALB2.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GTTTGAAGAACTTTCTTCAGA	0.338000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			27	59					0	0	0.000279167	0	0
AKAP11	11215	broad.mit.edu	37	13	42876436	42876436	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr13:42876436T>C	uc001uys.1	+	8	3729	c.3554T>C	c.(3553-3555)GTG>GCG	p.V1185A		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1185					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CTCCCAGAAGTGGATGTGAAG	0.413000													24	13					0	0	0.00047179	0	0
OR4M1	441670	broad.mit.edu	37	14	20248886	20248886	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr14:20248886C>T	uc010tku.1	+	1	405	c.405C>T	c.(403-405)ATC>ATT	p.I135I		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATGCTACCATCATGAATCGAC	0.498000													27	20					0	0	0.00058488	0	0
OR4N5	390437	broad.mit.edu	37	14	20612593	20612593	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr14:20612593G>A	uc010tla.1	+	1	699	c.699G>A	c.(697-699)AAG>AAA	p.K233K		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		CTGAAGGAAAGAGCAAGGCTA	0.498000													15	10					0	0	0.000219431	0	0
Unknown	0	broad.mit.edu	37	14	28734154	28734154	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr14:28734154C>T	uc001wqd.2	+	1	535	c.395C>T	c.(394-396)TCC>TTC	p.S132F						SubName: Full=cDNA FLJ60537, highly similar to BCL2/adenovirus E1B 19 kDa protein-interacting protein 3;																		CCAAGGAGTTCCTCTTTAAAC	0.463000													14	6					0	0	0.000308642	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70712768	70712768	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr14:70712768C>T	uc010ttg.1	-	1	1751	c.1100G>A	c.(1099-1101)GGA>GAA	p.G367E		NR_003951				SubName: Full=ADAM21-like protein;												0						AAAACGGTTTCCCTGAGAGTT	0.388000													24	62					0	0	0.00047179	0	0
ADAM21	8747	broad.mit.edu	37	14	70925826	70925826	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr14:70925826G>A	uc001xmd.2	+	1	1610	c.1610G>A	c.(1609-1611)GGA>GAA	p.G537E		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	537	Cys-rich.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AATTCTCAGGGAAACCGTTTT	0.383000													5	19					0	0	3.59834e-05	0	0
KCNK13	56659	broad.mit.edu	37	14	90651018	90651018	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr14:90651018C>T	uc001xye.1	+	2	1340	c.898C>T	c.(898-900)CCG>TCG	p.P300S		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	300	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				CGGGTGCTGCCCGCAATGCCA	0.552000													9	11					0	0	0.000673444	0	0
KIAA1409	57578	broad.mit.edu	37	14	94120313	94120313	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr14:94120313C>T	uc001ybv.1	+	36	5959	c.5876C>T	c.(5875-5877)TCG>TTG	p.S1959L	KIAA1409_uc001ybs.1_Missense_Mutation_p.S1937L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2114						integral to membrane		p.S1937L(1)		ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		ACCTTAGCCTCGTCTCTGATG	0.507000													7	27					0	0	0.000442599	0	0
AK7	122481	broad.mit.edu	37	14	96922720	96922720	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr14:96922720G>A	uc001yfn.2	+	11	1179	c.1135G>A	c.(1135-1137)GGA>AGA	p.G379R		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	379	Adenylate kinase.|ATP (Potential).|Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CCCTGCTGTGGGAAAATCCAG	0.438000													13	8					0	0	0.000308642	0	0
MIR495	574453	broad.mit.edu	37	14	101500125	101500125	+	RNA	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr14:101500125C>T	hsa-mir-495|MI0003135	+			c.34C>T																				0						ATGTTATTTTCGCTTTATATG	0.522000													6	5					0	0	0.000157383	0	0
ADAM6	8755	broad.mit.edu	37	14	107219119	107219119	+	RNA	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr14:107219119C>T	uc010tyt.1	-	11		c.696G>A								Parts of antibodies, mostly variable regions.												0						CCAGCTCAGCCCAAACTCCAT	0.512000													11	16					0	0	0.000219431	0	0
HERC2	8924	broad.mit.edu	37	15	28422610	28422610	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr15:28422610G>A	uc001zbj.2	-	60	9315	c.9209C>T	c.(9208-9210)TCG>TTG	p.S3070L		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3070	RCC1 8.			S -> W (in Ref. 3; AAO27475).	DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTCGCCCCACGAAAACACTTT	0.468000													20	26					0	0	0.000295444	0	0
FAM63B	54629	broad.mit.edu	37	15	59139614	59139614	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr15:59139614G>A	uc002afj.2	+	7	1689	c.1487G>A	c.(1486-1488)CGA>CAA	p.R496Q	FAM63B_uc002afi.2_Missense_Mutation_p.R496Q|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_RNA	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	hypothetical protein LOC54629 isoform a	496										central_nervous_system(1)	1						TTTCATCTTCGACCTCCTTCA	0.383000													13	32					0	0	0.00010058	0	0
SLC24A1	9187	broad.mit.edu	37	15	65946287	65946287	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr15:65946287C>T	uc010ujf.1	+	10	3457	c.3170C>T	c.(3169-3171)TCT>TTT	p.S1057F	SLC24A1_uc010uje.1_Intron|SLC24A1_uc010ujg.1_Missense_Mutation_p.S1027F|SLC24A1_uc010ujh.1_Missense_Mutation_p.S1039F|SLC24A1_uc010uji.1_Missense_Mutation_p.S384F	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	1057	Helical; (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						TTTGTGATCTCTTCAATTGCG	0.383000													39	123					0	0	0.000374591	0	0
TM6SF1	53346	broad.mit.edu	37	15	83791518	83791518	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr15:83791518G>A	uc002bjp.2	+	6	600	c.491G>A	c.(490-492)GGA>GAA	p.G164E	TM6SF1_uc010bmq.2_Missense_Mutation_p.G164E|TM6SF1_uc002bjq.2_Intron|TM6SF1_uc010bmr.2_Intron|TM6SF1_uc002bjr.2_Missense_Mutation_p.G16E	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	164						integral to membrane				ovary(1)	1						GGGAAGTATGGAACACGAATT	0.353000													22	18					0	0	0.000586117	0	0
AXIN1	8312	broad.mit.edu	37	16	343690	343690	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr16:343690G>A	uc002cgp.1	-	8	2161	c.1984C>T	c.(1984-1986)CAT>TAT	p.H662Y	AXIN1_uc002cgq.1_Missense_Mutation_p.H662Y	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	662	Interaction with RNF111.|Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GAGTTCTCATGGGGCTGTGGC	0.632000													29	24					0	0	0.000227799	0	0
WFIKKN1	117166	broad.mit.edu	37	16	683313	683313	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr16:683313G>A	uc002cht.1	+	2	1145	c.903G>A	c.(901-903)CCG>CCA	p.P301P	WFIKKN1_uc002chs.1_3'UTR	NM_053284	NP_444514	Q96NZ8	WFKN1_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz	301	BPTI/Kunitz inhibitor 1.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity				0		Hepatocellular(780;0.00335)				AGTGCCTGCCGGATGTGCAGG	0.716000													5	1					0	0	3.59834e-05	0	0
E4F1	1877	broad.mit.edu	37	16	2283184	2283184	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr16:2283184G>A	uc002cpm.2	+	7	1104	c.1056G>A	c.(1054-1056)GAG>GAA	p.E352E	E4F1_uc010bsi.2_Silent_p.E352E|E4F1_uc010bsj.2_Silent_p.E352E	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	352					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						TGGCCCCAGAGGTGGGGGCGA	0.657000													6	21					0	0	8.12818e-05	0	0
KCTD5	54442	broad.mit.edu	37	16	2747994	2747994	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr16:2747994C>T	uc002crd.2	+	3	504	c.449C>T	c.(448-450)TCG>TTG	p.S150L		NM_018992	NP_061865	Q9NXV2	KCTD5_HUMAN	potassium channel tetramerisation domain	150					interspecies interaction between organisms	cytosol|nucleus|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity				0						AGCAAAACATCGCAGGTGAGA	0.458000													7	11					0	0	8.12818e-05	0	0
OR1F1	4992	broad.mit.edu	37	16	3254843	3254843	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr16:3254843C>T	uc010uwu.1	+	1	597	c.597C>T	c.(595-597)ATC>ATT	p.I199I		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGTCATAATCCTTAGTGAGG	0.493000													19	22					0	0	0.000132079	0	0
ACSM2B	348158	broad.mit.edu	37	16	20559473	20559473	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr16:20559473C>T	uc002dhj.3	-	9	1219	c.1009G>A	c.(1009-1011)GGA>AGA	p.G337R	ACSM2B_uc002dhk.3_Missense_Mutation_p.G337R|ACSM2B_uc010bwf.1_Missense_Mutation_p.G337R	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	337					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GACTCCCCTCCAGCGAGGCAG	0.522000													23	36					0	0	9.22233e-05	0	0
DNAH3	55567	broad.mit.edu	37	16	21080788	21080788	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr16:21080788C>T	uc010vbe.1	-	23	3329	c.3329G>A	c.(3328-3330)GGG>GAG	p.G1110E		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1110	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AAATTTCCTCCCCTCTTCTGG	0.428000													17	31					0	0	0.000566183	0	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	Silent	SNP	G	A	A	rs150520281	by1000genomes	TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr16:21817457G>A	uc010vbl.1	-	7	603	c.106C>T	c.(106-108)CTG>TTG	p.L36L	uc002diq.3_Intron	NR_003370				SubName: Full=Putative uncharacterized protein ENSP00000219758;												0						CTTACATCCAGCTTGAGTAGT	0.254000													4	37					0	0	0.00024832	0	0
EXOSC6	118460	broad.mit.edu	37	16	70285795	70285795	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr16:70285795C>T	uc002eym.1	-	1	39	c.9G>A	c.(7-9)GGG>GGA	p.G3G		NM_058219	NP_478126	Q5RKV6	EXOS6_HUMAN	homolog of yeast mRNA transport regulator 3	3					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|isotype switching|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	RNA binding				0						GGCGGTGATCCCCAGGCATGG	0.697000											OREG0023912	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	1					0	0	3.59834e-05	0	0
FBXO31	79791	broad.mit.edu	37	16	87367562	87367562	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr16:87367562C>T	uc002fjw.2	-	8	1371	c.1327G>A	c.(1327-1329)GGG>AGG	p.G443R	FBXO31_uc010vot.1_Missense_Mutation_p.G271R|FBXO31_uc002fjv.2_Missense_Mutation_p.G335R	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	443					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		AACGGCTGCCCCTGCCCACAC	0.677000													6	5					0	0	3.59834e-05	0	0
ZMYND15	84225	broad.mit.edu	37	17	4646597	4646597	+	Splice_Site	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:4646597G>A	uc002fyt.2	+	6	1184	c.1145_splice	c.e6-1	p.E382_splice	ZMYND15_uc002fyv.2_Splice_Site_p.E382_splice|ZMYND15_uc002fyu.2_Splice_Site_p.E382_splice	NM_032265	NP_115641	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15 isoform 2								zinc ion binding				0						TCCTTCTCCAGAGGTGACCAG	0.448000													24	32					0	0	0.000147802	0	0
ZBTB4	57659	broad.mit.edu	37	17	7366747	7366747	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:7366747C>T	uc002ghc.3	-	4	1804	c.1554G>A	c.(1552-1554)AAG>AAA	p.K518K	ZBTB4_uc002ghd.3_Silent_p.K518K	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	518	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		ATTCTCGTTTCTTGGGTGGCC	0.667000													4	1					0	0	0.00024832	0	0
TRIM16	10626	broad.mit.edu	37	17	15518999	15519000	+	Missense_Mutation	DNP	GG	AT	AT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:15518999_15519000GG>AT	uc002gor.1	-	8	1896_1897	c.1559_1560CC>AT	c.(1558-1560)GCC>GAT	p.A520D	CDRT1_uc002gov.3_Missense_Mutation_p.A210D			O95361	TRI16_HUMAN	SubName: Full=Putative uncharacterized protein; Flags: Fragment;	Error:Variant_position_missing_in_O95361_after_alignment					histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		CATTTTCTGGGGCTTTGGACAA	0.411000													7	9					0	0	6.4e-05	0	0
SEZ6	124925	broad.mit.edu	37	17	27308689	27308689	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:27308689G>A	uc002hdp.2	-	2	618	c.424C>T	c.(424-426)CCG>TCG	p.P142S	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.P142S|SEZ6_uc002hdq.1_Missense_Mutation_p.P17S|SEZ6_uc010crz.1_Missense_Mutation_p.P142S	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	142	Pro-rich.|Extracellular (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			TCTGACTCCGGACTCCAGGGT	0.652000													4	9					0	0	0.00024832	0	0
ABHD15	116236	broad.mit.edu	37	17	27893340	27893340	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:27893340G>A	uc002hed.1	-	1	709	c.645C>T	c.(643-645)CTC>CTT	p.L215L	TP53I13_uc002hee.2_5'Flank	NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	215						extracellular region	carboxylesterase activity				0						CCGCCTCCTTGAGGTCGGACG	0.701000													5	10					0	0	3.59834e-05	0	0
ATAD5	79915	broad.mit.edu	37	17	29162841	29162841	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:29162841C>G	uc002hfs.1	+	2	2088	c.1742C>G	c.(1741-1743)TCT>TGT	p.S581C	ATAD5_uc002hft.1_Missense_Mutation_p.S478C	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	581					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AAAGCTGAATCTGAAGCCAGC	0.378000													12	55					0	0	6.40141e-05	0	0
ATAD5	79915	broad.mit.edu	37	17	29162877	29162877	+	Nonsense_Mutation	SNP	C	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:29162877C>G	uc002hfs.1	+	2	2124	c.1778C>G	c.(1777-1779)TCA>TGA	p.S593*	ATAD5_uc002hft.1_Nonsense_Mutation_p.S490*	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	593					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ACGCCCAAGTCAACTAGAAGA	0.383000													15	57					0	0	0.000566183	0	0
SLFN11	91607	broad.mit.edu	37	17	33679391	33679391	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:33679391G>A	uc010ctp.2	-	7	3132	c.2690C>T	c.(2689-2691)CCG>CTG	p.P897L	SLFN11_uc010ctq.2_Missense_Mutation_p.P897L|SLFN11_uc002hjh.3_Missense_Mutation_p.P897L|SLFN11_uc002hjg.3_Missense_Mutation_p.P897L|SLFN11_uc010ctr.2_Missense_Mutation_p.P897L	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	897						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCCACCCCACGGAAAAATATA	0.428000													13	45					0	0	0.000566183	0	0
KRT39	390792	broad.mit.edu	37	17	39122700	39122700	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:39122700G>A	uc002hvo.1	-	1	445	c.409C>T	c.(409-411)CCT>TCT	p.P137S	KRT39_uc010wfm.1_5'UTR	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	137	Linker 1.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				CATAGAACAGGGAGCTCTTTG	0.428000													14	82					0	0	0.000219431	0	0
KRTAP9-2	83899	broad.mit.edu	37	17	39382983	39382983	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:39382983C>T	uc002hwf.2	+	1	84	c.77C>T	c.(76-78)CCC>CTC	p.P26L		NM_031961	NP_114167	Q9BYQ4	KRA92_HUMAN	keratin associated protein 9.2	26	17 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]- [TASP].					keratin filament	protein binding			upper_aerodigestive_tract(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			TGCTGGAAGCCCACCACTGTG	0.642000													4	31					0	0	0.00024832	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411699	39411699	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:39411699C>T	uc010wfq.1	+	2	79	c.77C>T	c.(76-78)CCC>CTC	p.P26L		NM_030975	NP_112237	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	21						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			TGCTGGAAGCCCACCACTGTG	0.617000													4	10					0	0	0.00024832	0	0
AARSD1	80755	broad.mit.edu	37	17	41131281	41131281	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:41131281G>A	uc002icf.2	-	5	541	c.323C>T	c.(322-324)TCC>TTC	p.S108F	AARSD1_uc002icd.2_Missense_Mutation_p.S47F|AARSD1_uc002ice.2_Missense_Mutation_p.S47F|AARSD1_uc010whg.1_Missense_Mutation_p.S108F|AARSD1_uc002icg.2_RNA|AARSD1_uc002ich.2_Missense_Mutation_p.S70F|AARSD1_uc010whh.1_Intron|RUNDC1_uc002ici.1_5'Flank|RUNDC1_uc010whi.1_5'Flank	NM_025267	NP_079543	Q9BTE6	AASD1_HUMAN	alanyl-tRNA synthetase domain containing 1	Error:Variant_position_missing_in_Q9BTE6_after_alignment					alanyl-tRNA aminoacylation	cytoplasm	alanine-tRNA ligase activity|ATP binding|metal ion binding|nucleic acid binding				0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CTTATCCTGGGAGTCCTGCCA	0.512000													12	40					0	0	6.40141e-05	0	0
TANC2	26115	broad.mit.edu	37	17	61498624	61498624	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:61498624G>A	uc002jal.3	+	25	5304	c.5281G>A	c.(5281-5283)GAA>AAA	p.E1761K	TANC2_uc010wpe.1_3'UTR|TANC2_uc002jao.3_Missense_Mutation_p.E872K	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1761							binding			ovary(2)	2						CAACCCTAACGAAATCAAACC	0.507000													20	31					0	0	0.000132079	0	0
KCNH6	81033	broad.mit.edu	37	17	61623084	61623084	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:61623084G>A	uc002jay.2	+	14	2886	c.2806G>A	c.(2806-2808)GAA>AAA	p.E936K	KCNH6_uc010wpl.1_Missense_Mutation_p.E777K|KCNH6_uc010wpm.1_Missense_Mutation_p.E900K|KCNH6_uc002jaz.1_Missense_Mutation_p.E847K	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	936	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CTCAGAACAGGAACAGCCTGA	0.572000													4	22					0	0	0.000602214	0	0
GH1	2688	broad.mit.edu	37	17	61995207	61995207	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:61995207G>A	uc002jdj.2	-	4	431	c.369C>T	c.(367-369)TTC>TTT	p.F123F	GH1_uc002jdi.2_Silent_p.F108F|GH1_uc002jdk.2_Silent_p.F83F|GH1_uc002jdl.2_Intron|GH1_uc002jdm.2_Intron|GH1_uc002jdn.2_Intron	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	123					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						GGCTGTTGGCGAAGACACTCC	0.607000													23	12					0	0	0.000586117	0	0
KCNJ16	3773	broad.mit.edu	37	17	68128684	68128684	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:68128684C>T	uc002jin.2	+	5	942	c.456C>T	c.(454-456)CTC>CTT	p.L152L	KCNJ16_uc002jio.2_Silent_p.L152L|KCNJ16_uc002jip.2_Silent_p.L152L|KCNJ16_uc002jiq.2_Silent_p.L184L	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	152	Helical; Name=M2; (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					TGGTGATCCTCCAGTCCATCT	0.468000													7	38					0	0	0.000157383	0	0
RNF213	57674	broad.mit.edu	37	17	78319813	78319813	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr17:78319813C>T	uc002jyh.1	+	4	2120	c.1897C>T	c.(1897-1899)CCT>TCT	p.P633S		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GGGCTCCATTCCTCTGAGGCA	0.562000													11	15					0	0	6.40141e-05	0	0
CABLES1	91768	broad.mit.edu	37	18	20815896	20815896	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr18:20815896C>T	uc002kuc.2	+	6	1223	c.1223C>T	c.(1222-1224)GCC>GTC	p.A408V	C18orf45_uc010xaq.1_Intron|CABLES1_uc002kub.2_Intron|CABLES1_uc002kud.2_Missense_Mutation_p.A143V	NM_001100619	NP_001094089	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1 isoform 2	408	Interacts with CDK3 (By similarity).				blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)	1	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCCACAAATGCCTTTGGAGCC	0.512000													29	62					0	0	0.000339439	0	0
TAF4B	6875	broad.mit.edu	37	18	23872342	23872342	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr18:23872342C>T	uc002kvu.3	+	8	2212	c.1723C>T	c.(1723-1725)CCA>TCA	p.P575S	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.P580S	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	575					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			TCAGTTTCCTCCAGGTAGATG	0.423000													19	45					0	0	0.000295444	0	0
FAM59A	64762	broad.mit.edu	37	18	29867642	29867642	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr18:29867642G>A	uc002kxl.2	-	4	974	c.918C>T	c.(916-918)TTC>TTT	p.F306F	FAM59A_uc002kxk.1_Silent_p.F306F	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	306	CABIT.									ovary(1)|skin(1)	2						CTGGGAGGCTGAACTTGGGGA	0.527000													11	26					0	0	0.00010058	0	0
KIAA1328	57536	broad.mit.edu	37	18	34647250	34647250	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr18:34647250C>T	uc002kzz.2	+	7	996	c.974C>T	c.(973-975)CCT>CTT	p.P325L	KIAA1328_uc002lab.2_Missense_Mutation_p.P41L|KIAA1328_uc002lac.1_Missense_Mutation_p.P148L|KIAA1328_uc010dnc.1_RNA|KIAA1328_uc002lad.2_Missense_Mutation_p.P41L	NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	325										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		AACATGACCCCTCAACATCCT	0.473000													11	26					0	0	0.000422831	0	0
SLC14A2	8170	broad.mit.edu	37	18	43247925	43247925	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr18:43247925G>A	uc010dnj.2	+	15	2166	c.1845G>A	c.(1843-1845)GCG>GCA	p.A615A	SLC14A2_uc002lbe.2_Silent_p.A615A	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	615	Helical; (Potential).					apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CCTGGTGGGCGATCTCAGGCT	0.562000													18	32					0	0	0.000132079	0	0
SERPINB3	6317	broad.mit.edu	37	18	61322951	61322951	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr18:61322951G>A	uc002lji.2	-	8	1257	c.1113C>T	c.(1111-1113)TTC>TTT	p.F371F	SERPINB4_uc002ljg.2_Intron|SERPINB3_uc010dqa.2_Silent_p.F319F	NM_006919	NP_008850	P29508	SPB3_HUMAN	serine (or cysteine) proteinase inhibitor, clade	371					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GCCTTATGAAGAATAGGAAAG	0.443000													18	38					0	0	0.000175454	0	0
SERPINB8	5271	broad.mit.edu	37	18	61654137	61654137	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr18:61654137C>T	uc002ljv.2	+	7	919	c.750C>T	c.(748-750)TTC>TTT	p.F250F	SERPINB8_uc002lju.2_Silent_p.F250F|SERPINB8_uc010xex.1_Silent_p.F68F	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	250					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				ATGAGAAATTCAAAGCCTGGA	0.373000													68	79					0	0	0.000147903	0	0
FBXO15	201456	broad.mit.edu	37	18	71749176	71749176	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr18:71749176C>T	uc002lle.2	-	9	1357	c.1021G>A	c.(1021-1023)GAT>AAT	p.D341N	FBXO15_uc002lld.2_RNA|FBXO15_uc002llf.2_Missense_Mutation_p.D417N	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	341										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		ATACAGCCATCAAAAATATCA	0.284000													18	30					0	0	0.000295444	0	0
ZNF236	7776	broad.mit.edu	37	18	74639998	74639999	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr18:74639998_74639999GG>AA	uc002lmi.2	+	25	4722_4723	c.4524_4525GG>AA	c.(4522-4527)CAGGCC>CAAACC	p.A1509T	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1509					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TCCTGGCACAGGCCGCTGGGCC	0.545000													14	25					0	0	6.4e-05	0	0
ZNF77	58492	broad.mit.edu	37	19	2934250	2934250	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:2934250C>G	uc002lws.3	-	4	1006	c.875G>C	c.(874-876)GGA>GCA	p.G292A		NM_021217	NP_067040	Q15935	ZNF77_HUMAN	zinc finger protein 77	292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGTTTCTCTCCAGTGTGTGT	0.463000													3	61					0	0	6.4e-05	0	0
FBN3	84467	broad.mit.edu	37	19	8130862	8130862	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:8130862C>T	uc002mjf.2	-	63	8392	c.8371G>A	c.(8371-8373)GGG>AGG	p.G2791R	FBN3_uc002mje.2_Missense_Mutation_p.G587R	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2791						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCTGGCTGCCCCTCTGGCTGG	0.687000													9	17					0	0	0.000673444	0	0
ACTL9	284382	broad.mit.edu	37	19	8808406	8808406	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:8808406G>A	uc002mkl.2	-	1	767	c.646C>T	c.(646-648)CAC>TAC	p.H216Y		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	216						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						TCCGTGGCGTGGAGCAGGTTG	0.682000													6	18					0	0	8.12818e-05	0	0
MUC16	94025	broad.mit.edu	37	19	9049655	9049655	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:9049655G>A	uc002mkp.2	-	5	32180	c.31976C>T	c.(31975-31977)TCG>TTG	p.S10659L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10661	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATCTGTCCCCGAAATAGTGAC	0.498000													17	31					0	0	0.000175454	0	0
MUC16	94025	broad.mit.edu	37	19	9058623	9058623	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:9058623G>A	uc002mkp.2	-	3	29027	c.28823C>T	c.(28822-28824)CCC>CTC	p.P9608L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCACCAGAGGGCATCTTGTA	0.527000													6	8					0	0	8.12818e-05	0	0
MUC16	94025	broad.mit.edu	37	19	9085314	9085314	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:9085314C>T	uc002mkp.2	-	1	6705	c.6501G>A	c.(6499-6501)CCG>CCA	p.P2167P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2167	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGCCTAAACTCGGGTTAGCAG	0.468000													12	20					0	0	6.40141e-05	0	0
MAST1	22983	broad.mit.edu	37	19	12958212	12958212	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:12958212G>A	uc002mvm.2	+	5	564	c.436G>A	c.(436-438)GAG>AAG	p.E146K	MAST1_uc002mvk.2_Missense_Mutation_p.E142K|MAST1_uc002mvl.2_Silent_p.T119T	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	146					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CATCACAGACGAGGATGGTGG	0.652000											OREG0025277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	20					0	0	0.000442599	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13910553	13910553	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:13910553G>C	uc002mxh.1	+	2	362	c.173G>C	c.(172-174)CGG>CCG	p.R58P		NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	58							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CGGTTCTCCCGGGTGCCTGAG	0.398000													3	48					0	0	0.000602214	0	0
BRD4	23476	broad.mit.edu	37	19	15376315	15376315	+	Silent	SNP	G	A	A	rs141035305	by1000genomes	TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:15376315G>A	uc002nar.2	-	5	921	c.699C>T	c.(697-699)ATC>ATT	p.I233I	BRD4_uc002nas.2_Silent_p.I233I|BRD4_uc002nat.3_Silent_p.I233I|BRD4_uc002nau.3_Silent_p.I233I	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	233					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GGGTCTGGACGATGAGGTCCG	0.692000			T	NUT|C15orf55	lethal midline carcinoma of young people								15	25					0	0	0.000308642	0	0
RASAL3	64926	broad.mit.edu	37	19	15569352	15569352	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:15569352G>A	uc002nbe.2	-	7	863	c.777C>T	c.(775-777)CCC>CCT	p.P259P	RASAL3_uc010eaa.1_5'Flank	NM_022904	NP_075055	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	259	PH.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity				0						GAAAGCAGTGGGGCTCCCCCA	0.617000													5	3					0	0	3.59834e-05	0	0
CYP4F12	66002	broad.mit.edu	37	19	15807832	15807832	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:15807832G>A	uc002nbl.2	+	13	1573	c.1512G>A	c.(1510-1512)TTG>TTA	p.L504L		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					AGCTGGAATTGATCATGCGCG	0.582000													9	12					0	0	0.000274275	0	0
FCHO1	23149	broad.mit.edu	37	19	17881371	17881371	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:17881371G>A	uc010ebb.2	+	7	663	c.474G>A	c.(472-474)CAG>CAA	p.Q158Q	FCHO1_uc002nhg.3_Silent_p.Q158Q|FCHO1_uc002nhh.2_Silent_p.Q158Q|FCHO1_uc010xpw.1_Silent_p.Q108Q|FCHO1_uc010ebc.1_Silent_p.Q165Q	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	158	Potential.									breast(1)	1						GTACCAGCCAGAAGGAGATGG	0.627000													12	13					0	0	0.000219431	0	0
PDE4C	5143	broad.mit.edu	37	19	18322646	18322646	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:18322646C>T	uc010xqc.1	-	14	2194	c.1714G>A	c.(1714-1716)GGA>AGA	p.G572R	PDE4C_uc002nik.3_Missense_Mutation_p.G572R|PDE4C_uc002nil.3_Missense_Mutation_p.G572R|PDE4C_uc002nif.3_Missense_Mutation_p.G341R|PDE4C_uc002nig.3_Missense_Mutation_p.G287R|PDE4C_uc002nih.3_Missense_Mutation_p.G342R|PDE4C_uc010ebk.2_Missense_Mutation_p.G466R|PDE4C_uc002nii.3_Missense_Mutation_p.G540R|PDE4C_uc010ebl.2_Missense_Mutation_p.G286R	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	572					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	TCGCGGTCTCCCTGCTGGAAG	0.627000													9	24					0	0	0.000673444	0	0
CILP2	148113	broad.mit.edu	37	19	19655192	19655192	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:19655192G>A	uc002nmv.3	+	8	1923	c.1838G>A	c.(1837-1839)CGA>CAA	p.R613Q	CILP2_uc002nmw.3_Missense_Mutation_p.R619Q	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	613						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GTGGACCCCCGAGACCTCACC	0.697000													15	31					0	0	0.000422831	0	0
ZNF208	7757	broad.mit.edu	37	19	22157600	22157600	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:22157600G>A	uc002nqp.2	-	4	385	c.236C>T	c.(235-237)TCT>TTT	p.S79F	ZNF208_uc002nqo.1_Missense_Mutation_p.S79F|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGCAAAATGAGAACATATAAC	0.299000													5	14					0	0	0.000602214	0	0
CD22	933	broad.mit.edu	37	19	35835825	35835825	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:35835825G>A	uc010edt.2	+	10	2206	c.2129G>A	c.(2128-2130)CGA>CAA	p.R710Q	CD22_uc010xst.1_Missense_Mutation_p.R538Q|CD22_uc010edu.2_Missense_Mutation_p.R622Q|CD22_uc010edv.2_Missense_Mutation_p.R710Q|CD22_uc002nzb.3_Missense_Mutation_p.R533Q|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	710	Cytoplasmic (Potential).				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AAGCTCCAGCGACGGTGAGCT	0.642000													16	28					0	0	0.000308642	0	0
NPHS1	4868	broad.mit.edu	37	19	36339065	36339065	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:36339065G>A	uc002oby.2	-	11	1318	c.1318C>T	c.(1318-1320)CCC>TCC	p.P440S		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	440	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TTCTGGGCGGGATCTGGCGGG	0.617000													17	23					0	0	0.000422831	0	0
PSG1	5669	broad.mit.edu	37	19	43376012	43376013	+	Missense_Mutation	DNP	CC	AA	AA	rs1058697		TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:43376012_43376013CC>AA	uc002ovb.2	-	3	753_754	c.615_616GG>TT	c.(613-618)TTGGGT>TTTTGT	p.205_206LG>FC	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.205_206LG>FC|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.205_206LG>FC|PSG1_uc010eio.1_Missense_Mutation_p.205_206LG>FC|PSG1_uc002oux.1_Missense_Mutation_p.134_135LG>FC|PSG1_uc002ouy.1_Missense_Mutation_p.205_206LG>FC|PSG1_uc002ouz.1_Missense_Mutation_p.205_206LG>FC|PSG1_uc002ova.1_Intron|PSG1_uc002ovc.2_Intron|PSG1_uc002ovd.1_Missense_Mutation_p.205_206LG>FC	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	205_206	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TTTGTGACACCCAATAGAAAGA	0.520000													9	178					0	0	6.4e-05	0	0
PSG7	5676	broad.mit.edu	37	19	43439843	43439843	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:43439843C>T	uc002ovl.3	-	2	245	c.143G>A	c.(142-144)GGG>GAG	p.G48E	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	48	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				AACATCCTTCCCCTCGGAAAC	0.483000													38	89					0	0	0.000191422	0	0
PSG5	5673	broad.mit.edu	37	19	43679501	43679501	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:43679501C>T	uc002ovu.2	-	4	961	c.830G>A	c.(829-831)GGG>GAG	p.G277E	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.G152E|PSG5_uc002ovx.2_Missense_Mutation_p.G277E|PSG5_uc002ovv.2_Missense_Mutation_p.G370E|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	277	Ig-like C2-type 2.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				CTGAAACTTCCCATTAATTGT	0.438000													34	145					0	0	0.00058488	0	0
ZNF229	7772	broad.mit.edu	37	19	44933745	44933745	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:44933745G>A	uc002oze.1	-	6	1645	c.1211C>T	c.(1210-1212)CCA>CTA	p.P404L	ZNF229_uc010ejk.1_Missense_Mutation_p.P58L|ZNF229_uc010ejl.1_Missense_Mutation_p.P398L	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				GCATTTATATGGTTTCTCTCC	0.522000													18	29					0	0	9.7654e-05	0	0
CLPTM1	1209	broad.mit.edu	37	19	45489774	45489774	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:45489774A>G	uc002pai.2	+	7	749	c.734A>G	c.(733-735)AAC>AGC	p.N245S	CLPTM1_uc010ejv.1_Missense_Mutation_p.N143S|CLPTM1_uc010xxf.1_Missense_Mutation_p.N143S|CLPTM1_uc010xxg.1_Missense_Mutation_p.N231S	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	245	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		ATCACCATCAACATCGTGGAC	0.617000													46	101					0	0	0.000147903	0	0
CCDC61	729440	broad.mit.edu	37	19	46509959	46509959	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:46509959C>T	uc002pdw.2	+	5	545	c.545C>T	c.(544-546)TCC>TTC	p.S182F		NM_001080402	NP_001073871			coiled-coil domain containing 61											ovary(1)	1		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		CTCATCTACTCCGTGGAGTTT	0.667000													23	23					0	0	0.00047179	0	0
LMTK3	114783	broad.mit.edu	37	19	49012191	49012191	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:49012191G>A	uc002pjk.2	-	6	561	c.561C>T	c.(559-561)CCC>CCT	p.P187P		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CCACCTGGGCGGGGGTGTAGT	0.637000													13	33					0	0	0.000308642	0	0
KLK12	43849	broad.mit.edu	37	19	51535154	51535154	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:51535154C>G	uc002pvg.1	-	3	555	c.435G>C	c.(433-435)TGG>TGC	p.W145C	KLK12_uc010ycp.1_RNA|KLK12_uc010ycq.1_Intron|KLK12_uc010ycr.1_Intron|KLK12_uc010ycs.1_Intron|KLK12_uc002pvh.1_Missense_Mutation_p.W145C|KLK12_uc002pvi.1_Missense_Mutation_p.W145C|KLK12_uc002pvj.1_Intron	NM_145894	NP_665901	Q9UKR0	KLK12_HUMAN	kallikrein 12 isoform 2	145	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			ovary(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		TGGTGATGCCCCAGCCTGAGA	0.657000													3	56					0	0	6.4e-05	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034594	52034594	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:52034594C>T	uc002pwy.2	-	2	409	c.247G>A	c.(247-249)GAA>AAA	p.E83K	SIGLEC6_uc002pwz.2_Missense_Mutation_p.E83K|SIGLEC6_uc002pxa.2_Missense_Mutation_p.E83K|SIGLEC6_uc010ydb.1_Missense_Mutation_p.E36K|SIGLEC6_uc010ydc.1_Missense_Mutation_p.E72K|SIGLEC6_uc010eoz.1_Missense_Mutation_p.E72K|SIGLEC6_uc010epb.1_Missense_Mutation_p.E36K|SIGLEC6_uc010epa.1_Missense_Mutation_p.E72K	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	83	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TGCACTTCTTCGTCTGGGTCG	0.582000													12	23					0	0	6.40141e-05	0	0
ZNF610	162963	broad.mit.edu	37	19	52869199	52869199	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:52869199C>T	uc002pyx.3	+	6	974	c.568C>T	c.(568-570)CCA>TCA	p.P190S	ZNF610_uc002pyy.3_Missense_Mutation_p.P190S|ZNF610_uc002pyz.3_Missense_Mutation_p.P147S|ZNF610_uc002pza.2_Missense_Mutation_p.P190S	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		CCCATTACTCCCACAAGAAGA	0.333000													11	65					0	0	0.000673444	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55294979	55294979	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:55294979G>A	uc002qhb.1	+	7	897	c.859G>A	c.(859-861)GCG>ACG	p.A287T	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_5'Flank|KIR2DL3_uc010erw.1_Missense_Mutation_p.A288T|KIR2DL1_uc002qgz.1_Missense_Mutation_p.A197T|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.A313T	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	287	Cytoplasmic (Potential).				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		AAACAGAACAGCGAATAGCGA	0.522000													19	32					0	0	0.000295444	0	0
NLRP11	204801	broad.mit.edu	37	19	56321408	56321408	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:56321408C>T	uc010ygf.1	-	5	1279	c.568G>A	c.(568-570)GAA>AAA	p.E190K	NLRP11_uc002qlz.2_Missense_Mutation_p.E91K|NLRP11_uc002qmb.2_Missense_Mutation_p.E91K|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	190	NACHT.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TGGTTTATTTCGTGAGCAGTG	0.493000													9	19					0	0	0.000673444	0	0
NLRP5	126206	broad.mit.edu	37	19	56539225	56539225	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr19:56539225G>A	uc002qmj.2	+	7	1626	c.1626G>A	c.(1624-1626)AGG>AGA	p.R542R	NLRP5_uc002qmi.2_Silent_p.R523R	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	542	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGTGGAATAGGAAGTCAGTGT	0.562000													9	11					0	0	0.000442599	0	0
APOB	338	broad.mit.edu	37	2	21236077	21236077	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:21236077T>C	uc002red.2	-	25	4299	c.4171A>G	c.(4171-4173)ATG>GTG	p.M1391V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1391					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAGCCTTCATGTGGTAACGA	0.532000													56	45					0	0	0.000147903	0	0
APOB	338	broad.mit.edu	37	2	21249769	21249770	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:21249769_21249770GG>TT	uc002red.2	-	15	2262_2263	c.2134_2135CC>AA	c.(2134-2136)CCA>AAA	p.P712K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	712					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GACACTGTCTGGGAAAAATCCT	0.411000													13	173					0	0	6.4e-05	0	0
TGFA	7039	broad.mit.edu	37	2	70680389	70680389	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:70680389G>A	uc002sgs.3	-	5	642	c.436C>T	c.(436-438)CTC>TTC	p.L146F	TGFA_uc010fdq.2_Missense_Mutation_p.L152F|TGFA_uc010fdr.2_Missense_Mutation_p.L151F|TGFA_uc002sgt.3_Missense_Mutation_p.L145F|TGFA_uc002sgu.2_Missense_Mutation_p.L145F|TGFA_uc002sgv.2_Missense_Mutation_p.L146F|TGFA_uc002sgw.2_Missense_Mutation_p.L145F	NM_003236	NP_003227	P01135	TGFA_HUMAN	transforming growth factor, alpha isoform 1	146	Cytoplasmic (Potential).				activation of MAPK activity|cell proliferation|positive regulation of cell division|positive regulation of epidermal growth factor receptor activity|positive regulation of epithelial cell proliferation|positive regulation of mitosis	cell surface|extracellular space|integral to membrane|plasma membrane	epidermal growth factor receptor binding|growth factor activity|MAP kinase kinase activity|signal transducer activity			prostate(1)	1						CCCTTCAGGAGGGCGCTGGGC	0.587000													13	30					0	0	0.000566183	0	0
AFF3	3899	broad.mit.edu	37	2	100210279	100210279	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:100210279C>T	uc002tag.2	-	14	2080	c.1844G>A	c.(1843-1845)GGG>GAG	p.G615E	AFF3_uc002taf.2_Missense_Mutation_p.G640E|AFF3_uc010fiq.1_Missense_Mutation_p.G615E|AFF3_uc010yvr.1_Missense_Mutation_p.G768E|AFF3_uc002tah.1_Missense_Mutation_p.G640E	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	615					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CACGCTCGTCCCCAGCGCGTC	0.731000													15	5					0	0	0.000566183	0	0
IL1RL1	9173	broad.mit.edu	37	2	102955354	102955354	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:102955354G>A	uc002tbu.1	+	3	390	c.119G>A	c.(118-120)GGA>GAA	p.G40E	IL1RL1_uc010ywa.1_Intron|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Missense_Mutation_p.G40E	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	40	Extracellular (Potential).|Ig-like C2-type 1.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CCTAGACAAGGAAAACCTAGT	0.383000													17	55					0	0	7.07596e-05	0	0
DDX11L2	84771	broad.mit.edu	37	2	114357735	114357735	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:114357735G>C	uc010yxx.1	-	3	531	c.204C>G	c.(202-204)CAC>CAG	p.H68Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						AGGGTGCCGGGTGTATCACTG	0.567000													2	3					0	0	6.4e-05	0	0
MARCO	8685	broad.mit.edu	37	2	119752009	119752009	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:119752009G>A	uc002tln.1	+	17	1608	c.1476G>A	c.(1474-1476)GAG>GAA	p.E492E	MARCO_uc010yyf.1_Silent_p.E414E	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	492	SRCR.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGGGCACGGAGAGTACCCTGT	0.557000													9	6					0	0	0.000442599	0	0
KYNU	8942	broad.mit.edu	37	2	143676226	143676226	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:143676226G>A	uc002tvl.2	+	3	348	c.218G>A	c.(217-219)GGA>GAA	p.G73E	KYNU_uc002tvk.2_Missense_Mutation_p.G73E|KYNU_uc010fnm.2_Missense_Mutation_p.G73E	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	73					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TATTTCTTGGGAAATTCTCTT	0.279000													18	20					0	0	0.000566183	0	0
FMNL2	114793	broad.mit.edu	37	2	153475652	153475652	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:153475652C>T	uc002tye.2	+	14	1974	c.1607C>T	c.(1606-1608)TCA>TTA	p.S536L	FMNL2_uc010fob.2_5'Flank|FMNL2_uc002tyf.2_5'Flank	NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	536	Pro-rich.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						CTGCCTCCCTCATCAGACACA	0.458000													5	14					0	0	0.000602214	0	0
TANC1	85461	broad.mit.edu	37	2	160084340	160084340	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:160084340T>A	uc002uag.2	+	25	4188	c.3914T>A	c.(3913-3915)ATG>AAG	p.M1305K	TANC1_uc010zcm.1_Missense_Mutation_p.M1297K|TANC1_uc010fom.1_Missense_Mutation_p.M1111K|TANC1_uc010fon.2_Missense_Mutation_p.M149K	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1305	TPR 1.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						AAAGGGAAAATGAAAGAGGCA	0.433000													4	12					0	0	3.59834e-05	0	0
SCN7A	6332	broad.mit.edu	37	2	167284358	167284358	+	Silent	SNP	T	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:167284358T>C	uc002udu.1	-	17	2920	c.2793A>G	c.(2791-2793)GTA>GTG	p.V931V	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	931	Helical; Name=S1 of repeat III; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AATTGTTCTCTACAATCTTGC	0.468000													4	9					0	0	0.00024832	0	0
XIRP2	129446	broad.mit.edu	37	2	168107877	168107877	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:168107877C>T	uc002udx.2	+	8	9993	c.9975C>T	c.(9973-9975)TTC>TTT	p.F3325F	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.F3150F|XIRP2_uc010fpq.2_Silent_p.F3103F|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3150					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTGAAAATTTCGTGAATGACC	0.448000													16	21					0	0	0.000422831	0	0
MYO3B	140469	broad.mit.edu	37	2	171375994	171375994	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:171375994C>T	uc002ufy.2	+	30	3662	c.3519C>T	c.(3517-3519)TCC>TCT	p.S1173S	MYO3B_uc002ufv.2_Silent_p.S1160S|MYO3B_uc010fqb.1_Silent_p.S1160S|MYO3B_uc002ufz.2_Silent_p.S1146S|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	1173					response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						AAGCAGAATCCAACAATGGCC	0.468000													11	18					0	0	0.00010058	0	0
TTN	7273	broad.mit.edu	37	2	179585787	179585787	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:179585787C>T	uc010zfg.1	-	76	19451	c.19227G>A	c.(19225-19227)TGG>TGA	p.W6409*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.W3070*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7336							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTGTATTTCCAACTTTCAT	0.413000													14	67					0	0	0.000308642	0	0
TTN	7273	broad.mit.edu	37	2	179634931	179634931	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:179634931C>T	uc010zfg.1	-	36	8721	c.8497G>A	c.(8497-8499)GAA>AAA	p.E2833K	TTN_uc010zfh.1_Missense_Mutation_p.E2787K|TTN_uc010zfi.1_Missense_Mutation_p.E2787K|TTN_uc010zfj.1_Missense_Mutation_p.E2787K|TTN_uc002unb.2_Missense_Mutation_p.E2833K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2833							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTTAATTTCCACACTCTTA	0.458000													43	38					0	0	0.000147903	0	0
NCKAP1	10787	broad.mit.edu	37	2	183841668	183841668	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:183841668C>T	uc002upc.2	-	15	1837	c.1435G>A	c.(1435-1437)GAA>AAA	p.E479K	NCKAP1_uc002upb.2_Missense_Mutation_p.E485K	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	479					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TCAAATACTTCCCCATCTTCA	0.259000													6	11					0	0	0.000157383	0	0
ZNF804A	91752	broad.mit.edu	37	2	185798364	185798364	+	Missense_Mutation	SNP	G	A	A	rs145158210		TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:185798364G>A	uc002uph.2	+	3	884	c.290G>A	c.(289-291)CGA>CAA	p.R97Q		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	97						intracellular	zinc ion binding	p.R97Q(1)		ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAATTTGCTCGAAATGTAGCA	0.368000													26	21					0	0	0.000184323	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187703734	187703734	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:187703734A>T	uc002upu.1	-	4	486	c.446T>A	c.(445-447)ATT>AAT	p.I149N		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	149	RING-type 1.				apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			CTCTTGACAAATAGAGCAGAT	0.333000													28	49					0	0	0.000692331	0	0
SLC40A1	30061	broad.mit.edu	37	2	190440039	190440039	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:190440039C>T	uc002uqp.3	-	3	470	c.119G>A	c.(118-120)CGG>CAG	p.R40Q	SLC40A1_uc002uqq.2_Missense_Mutation_p.R40Q	NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	40					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			GTGCCACATCCGATCTCCCTT	0.448000													7	32					0	0	8.12818e-05	0	0
DNAH7	56171	broad.mit.edu	37	2	196729544	196729544	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:196729544C>T	uc002utj.3	-	41	6936	c.6835G>A	c.(6835-6837)GAG>AAG	p.E2279K		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2279					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTGGTATCCTCCCTCTTGGGA	0.378000													21	49					0	0	0.000375601	0	0
WDR12	55759	broad.mit.edu	37	2	203748930	203748931	+	Silent	DNP	GG	TT	TT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:203748930_203748931GG>TT	uc002uzl.2	-	10	1728_1729	c.978_979CC>AA	c.(976-981)CCCCGA>CCAAGA	p.326_327PR>PR	WDR12_uc010ftt.2_Silent_p.326_327PR>PR	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	326_327	WD 5.|Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						CCTTTAGTTCGGGGATCCCACA	0.366000													7	179					0	0	6.4e-05	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208773276	208773276	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:208773276G>A	uc002vcl.2	-	6	2402	c.1912C>T	c.(1912-1914)CAA>TAA	p.Q638*	PLEKHM3_uc002vcm.2_Silent_p.F652F	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	638					intracellular signal transduction		metal ion binding			ovary(1)	1						TGGATCTGTTGAAGGAGGTAT	0.443000													24	25					0	0	0.000147802	0	0
ERBB4	2066	broad.mit.edu	37	2	212495299	212495299	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:212495299C>T	uc002veg.1	-	17	2065	c.1967G>A	c.(1966-1968)GGA>GAA	p.G656E	ERBB4_uc002veh.1_Missense_Mutation_p.G656E|ERBB4_uc010zji.1_Missense_Mutation_p.G646E|ERBB4_uc010zjj.1_Missense_Mutation_p.G646E|ERBB4_uc010fut.1_Missense_Mutation_p.G656E	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	656	Potential.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ACCAATTACTCCAGCTGCAAT	0.393000										TSP Lung(8;0.080)			7	39					0	0	0.000274275	0	0
PTPRN	5798	broad.mit.edu	37	2	220164775	220164775	+	Silent	SNP	G	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:220164775G>T	uc002vkz.2	-	9	1457	c.1368C>A	c.(1366-1368)CCC>CCA	p.P456P	PTPRN_uc010zlc.1_Silent_p.P366P|PTPRN_uc002vla.2_Silent_p.P456P	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	456	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CTGCCACCGTGGGCTGGCTCT	0.602000													17	26					1.37522e-17	2.11341e-16	9.7654e-05	1	0
COL4A4	1286	broad.mit.edu	37	2	227886863	227886863	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:227886863C>T	uc010zlt.1	-	43	4771	c.4117G>A	c.(4117-4119)GAT>AAT	p.D1373N		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1373	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GGACAGTCATCCACATCTGCA	0.572000													21	65					0	0	0.000229342	0	0
DIS3L2	129563	broad.mit.edu	37	2	233001212	233001212	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:233001212C>T	uc010fxz.2	+	8	1009	c.733C>T	c.(733-735)CGA>TGA	p.R245*	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	245							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		AAAACATTCTCGAGCAGCAAC	0.433000													9	46					0	0	0.000442599	0	0
SH3BP4	23677	broad.mit.edu	37	2	235951000	235951000	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:235951000C>T	uc002vvp.2	+	4	1980	c.1587C>T	c.(1585-1587)TTC>TTT	p.F529F	SH3BP4_uc010fym.2_Silent_p.F529F|SH3BP4_uc002vvq.2_Silent_p.F529F	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	529					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		AGCACCAGTTCGTTTTGTCCA	0.592000													12	9					0	0	0.000219431	0	0
IQCA1	79781	broad.mit.edu	37	2	237308114	237308114	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:237308114C>T	uc002vvz.1	-	9	1334	c.1152G>A	c.(1150-1152)TGG>TGA	p.W384*	IQCA1_uc002vwb.2_Nonsense_Mutation_p.W391*|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Nonsense_Mutation_p.W343*	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	384	Lys-rich.						ATP binding			ovary(1)	1						GTGACATTTTCCATTTTTCGT	0.458000													12	61					0	0	0.00010058	0	0
MTERFD2	130916	broad.mit.edu	37	2	242036799	242036799	+	Silent	SNP	G	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr2:242036799G>C	uc002wan.1	-	2	1144	c.651C>G	c.(649-651)ACC>ACG	p.T217T	MTERFD2_uc010zoj.1_5'UTR|MTERFD2_uc010zok.1_Silent_p.T188T	NM_182501	NP_872307	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	188										ovary(1)	1		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		GCTGGCGCATGGTGAAAATTT	0.448000													4	51					0	0	0.00024832	0	0
PAK7	57144	broad.mit.edu	37	20	9523346	9523346	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr20:9523346T>G	uc002wnl.2	-	10	2436	c.1891A>C	c.(1891-1893)ATC>CTC	p.I631L	PAK7_uc002wnk.2_Missense_Mutation_p.I631L|PAK7_uc002wnj.2_Missense_Mutation_p.I631L|PAK7_uc010gby.1_Intron	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	631	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ATCACCATGATCCCGAGGGAC	0.517000													5	32					0	0	0.000602214	0	0
TTLL9	164395	broad.mit.edu	37	20	30496448	30496448	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr20:30496448C>T	uc010gdx.1	+	5	514	c.261C>T	c.(259-261)TTC>TTT	p.F87F	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_RNA|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Intron|TTLL9_uc010ztp.1_RNA|TTLL9_uc010ztq.1_5'Flank	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	87	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GGGAGAACTTCGACCACACCT	0.592000													5	9					0	0	3.59834e-05	0	0
SUN5	140732	broad.mit.edu	37	20	31577456	31577456	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr20:31577456C>T	uc002wyi.2	-	9	676	c.583G>A	c.(583-585)GAA>AAA	p.E195K		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	195					spermatogenesis					skin(1)	1						TCTGGCTTTTCGATGTAATCT	0.488000													9	21					0	0	0.00010058	0	0
EPB41L1	2036	broad.mit.edu	37	20	34775631	34775631	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr20:34775631C>T	uc002xfb.2	+	8	990	c.819C>T	c.(817-819)TTC>TTT	p.F273F	EPB41L1_uc002xeu.2_Silent_p.F211F|EPB41L1_uc010zvo.1_Silent_p.F273F|EPB41L1_uc002xev.2_Silent_p.F273F|EPB41L1_uc002xew.2_Silent_p.F176F|EPB41L1_uc002xex.2_Silent_p.F242F|EPB41L1_uc002xey.2_Silent_p.F200F|EPB41L1_uc002xez.2_Silent_p.F211F	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	273	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					AAATCCACTTCTTAGAGAATG	0.552000													5	12					0	0	0.000157383	0	0
TGIF2	60436	broad.mit.edu	37	20	35207364	35207364	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr20:35207364C>T	uc002xfn.2	+	2	360	c.187C>T	c.(187-189)CTG>TTG	p.L63L	C20orf24_uc002xfo.2_Silent_p.L63L	NM_021809	NP_068581	Q9GZN2	TGIF2_HUMAN	TGFB-induced factor homeobox 2	63	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)|skin(1)	2	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				CCTGTCAGTGCTGCAAGTAAG	0.363000													5	22					0	0	0.000157383	0	0
PTPRT	11122	broad.mit.edu	37	20	41408906	41408906	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr20:41408906G>A	uc002xkg.2	-	4	704	c.520C>T	c.(520-522)CCT>TCT	p.P174S	PTPRT_uc010ggj.2_Missense_Mutation_p.P174S	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	174	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATGTAGCCAGGATGACCCTTC	0.522000													13	30					0	0	0.000151284	0	0
WFDC10B	280664	broad.mit.edu	37	20	44313574	44313574	+	Silent	SNP	G	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr20:44313574G>T	uc002xpb.2	-	4	348	c.117C>A	c.(115-117)CCC>CCA	p.P39P	WFDC10B_uc002xpc.2_Silent_p.P55P	NM_172006	NP_742003	Q8IUB3	WF10B_HUMAN	WAP four-disulfide core domain 10B isoform a	39	WAP.					extracellular region	peptidase inhibitor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GATCTATGCTGGGTCGCTTCT	0.448000													21	20					2.32416e-17	3.56228e-16	0.000295444	1	0
BCAS1	8537	broad.mit.edu	37	20	52601880	52601880	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr20:52601880G>A	uc002xws.2	-	7	1424	c.1086C>T	c.(1084-1086)ACC>ACT	p.T362T	BCAS1_uc010zza.1_Silent_p.T120T|BCAS1_uc010zzb.1_Silent_p.T310T|BCAS1_uc010gim.2_Silent_p.T310T|BCAS1_uc002xwt.2_Silent_p.T362T|BCAS1_uc010gil.1_Silent_p.T362T	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	362						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			ATTTCTCCTTGGTGCCTTCCT	0.547000													25	45					0	0	0.000227799	0	0
AURKA	6790	broad.mit.edu	37	20	54956548	54956548	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr20:54956548C>T	uc002xxd.1	-	8	1212	c.646G>A	c.(646-648)GGA>AGA	p.G216R	AURKA_uc002xxe.1_Missense_Mutation_p.G216R|AURKA_uc002xxf.1_Missense_Mutation_p.G216R|AURKA_uc002xxg.1_Missense_Mutation_p.G216R|AURKA_uc002xxh.1_Missense_Mutation_p.G216R|AURKA_uc002xxi.1_Missense_Mutation_p.G216R|AURKA_uc002xxj.1_Missense_Mutation_p.G216R|AURKA_uc002xxk.1_Missense_Mutation_p.G216R|AURKA_uc010zzd.1_RNA	NM_198433	NP_940835	O14965	AURKA_HUMAN	serine/threonine protein kinase 6	216	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(1)|large_intestine(1)|skin(1)	8			Colorectal(105;0.202)			TAAACTGTTCCAAGTGGTGCA	0.363000													25	26					0	0	0.00047179	0	0
TFF1	7031	broad.mit.edu	37	21	43783454	43783454	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr21:43783454G>A	uc002zax.1	-	2	188	c.148C>T	c.(148-150)CAG>TAG	p.Q50*		NM_003225	NP_003216	P04155	TFF1_HUMAN	trefoil factor 1 precursor	50	P-type.				carbohydrate metabolic process|response to estradiol stimulus		growth factor activity				0						TTTGCACACTGGGAGGGCGTG	0.532000													6	15					0	0	8.12818e-05	0	0
DGCR2	9993	broad.mit.edu	37	22	19055627	19055627	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr22:19055627G>A	uc002zoq.1	-	3	562	c.314C>T	c.(313-315)CCC>CTC	p.P105L	DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Missense_Mutation_p.P64L	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	105	Extracellular (Potential).				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					GAAGCGAACGGGCTGCGCCAC	0.642000													6	13					0	0	0.000274275	0	0
CYTSA	23384	broad.mit.edu	37	22	24718497	24718497	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr22:24718497A>G	uc002zzw.2	+	5	1856	c.1549A>G	c.(1549-1551)AGC>GGC	p.S517G	CYTSA_uc002zzv.3_Missense_Mutation_p.S517G|CYTSA_uc011ajq.1_Missense_Mutation_p.S517G	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	517	Potential.				cell cycle|cell division						0						GCAGCATTTAAGCAATACTTT	0.443000													18	35					0	0	0.000175454	0	0
PES1	23481	broad.mit.edu	37	22	30974944	30974944	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr22:30974944C>T	uc003aij.1	-	14	1637	c.1563G>A	c.(1561-1563)AAG>AAA	p.K521K	PES1_uc003aik.1_Silent_p.K516K|PES1_uc003ail.1_Silent_p.K504K|PES1_uc003aim.1_Silent_p.K520K|PES1_uc003ain.1_Silent_p.K382K|PES1_uc003aio.1_Silent_p.K382K	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	521	Glu-rich.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						CCAGCCGCTGCTTATCCTCCA	0.582000													8	21					0	0	0.000274275	0	0
MORC2	22880	broad.mit.edu	37	22	31338215	31338215	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr22:31338215G>A	uc003aje.1	-	8	1648	c.284C>T	c.(283-285)CCT>CTT	p.P95L		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	157							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						GTCTGTGACAGGTTCCCGGGT	0.502000													24	49					0	0	0.000147802	0	0
C22orf33	339669	broad.mit.edu	37	22	37398071	37398071	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr22:37398071C>T	uc003aqf.2	-	3	442	c.296G>A	c.(295-297)CGA>CAA	p.R99Q	C22orf33_uc003aqe.2_Missense_Mutation_p.R14Q	NM_001163857	NP_001157329	O43247	EAN57_HUMAN	hypothetical protein LOC339669 isoform 1	99											0						CGAGGAGGATCGAGAGCCCGC	0.647000													7	8					0	0	8.12818e-05	0	0
TNRC6B	23112	broad.mit.edu	37	22	40681768	40681768	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr22:40681768C>T	uc011aor.1	+	12	3913	c.3702C>T	c.(3700-3702)TCC>TCT	p.S1234S	TNRC6B_uc003aym.2_Silent_p.S430S|TNRC6B_uc003ayn.3_Silent_p.S1124S|TNRC6B_uc003ayo.2_Silent_p.S981S	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	1234					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						AGTTTATTTCCCCCCAGGTAA	0.448000													44	62					0	0	0.000147903	0	0
FBLN1	2192	broad.mit.edu	37	22	45929726	45929727	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr22:45929726_45929727GG>AA	uc003bgj.1	+	7	879_880	c.732_733GG>AA	c.(730-735)CGGGAC>CGAAAC	p.D245N	FBLN1_uc003bgg.1_Missense_Mutation_p.D245N|FBLN1_uc003bgh.2_Missense_Mutation_p.D245N|FBLN1_uc010gzz.2_Missense_Mutation_p.D283N|FBLN1_uc003bgi.1_Missense_Mutation_p.D245N	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	245	EGF-like 2; calcium-binding (Potential).				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GCTGCCAGCGGGACAGCAGCTG	0.569000													20	58					0	0	6.4e-05	0	0
CNTN4	152330	broad.mit.edu	37	3	2908551	2908551	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:2908551G>A	uc003bpc.2	+	7	791	c.570G>A	c.(568-570)GGG>GGA	p.G190G	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Silent_p.G190G	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	190	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CAGATGTTGGGAATTATACCT	0.408000													9	31					0	0	0.000442599	0	0
ITPR1	3708	broad.mit.edu	37	3	4853113	4853114	+	Missense_Mutation	DNP	AG	GA	GA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:4853113_4853114AG>GA	uc003bqa.2	+	53	7641_7642	c.7293_7294AG>GA	c.(7291-7296)GTAGAT>GTGAAT	p.D2432N	ITPR1_uc010hca.1_Missense_Mutation_p.D2417N|ITPR1_uc011asu.1_Missense_Mutation_p.D443N|ITPR1_uc003bqc.2_Missense_Mutation_p.D1402N|ITPR1_uc010hcc.1_Missense_Mutation_p.D200N|ITPR1_uc011asv.1_Missense_Mutation_p.D156N	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2480	Lumenal (Potential).|Interaction with ERP44 (By similarity).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TCTTGGAAGTAGATAGGCTGCC	0.406000													16	45					0	0	6.4e-05	0	0
SLC6A6	6533	broad.mit.edu	37	3	14485187	14485187	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:14485187G>A	uc010heg.2	+	10	336	c.45G>A	c.(43-45)AAG>AAA	p.K15K	SLC6A6_uc010hee.1_Silent_p.K15K|SLC6A6_uc003byp.2_Silent_p.K15K|SLC6A6_uc010hef.1_RNA|SLC6A6_uc003byq.2_Silent_p.K15K|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	15	Cytoplasmic (Potential).				cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						ATTTCCACAAGGACATCCTGA	0.562000													10	32					0	0	0.000673444	0	0
TTC21A	199223	broad.mit.edu	37	3	39162558	39162558	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:39162558C>T	uc003cjc.2	+	9	1172	c.995C>T	c.(994-996)TCG>TTG	p.S332L	TTC21A_uc003cje.2_Missense_Mutation_p.S332L|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.S283L	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	332							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GCCACCCCCTCGTATGTCCAT	0.512000													10	14					0	0	0.000673444	0	0
PLXNB1	5364	broad.mit.edu	37	3	48461145	48461146	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:48461145_48461146GG>AA	uc003csw.2	-	11	2819_2820	c.2549_2550CC>TT	c.(2548-2550)CCC>CTT	p.P850L	PLXNB1_uc003csu.2_Intron|PLXNB1_uc003csx.2_Missense_Mutation_p.P850L|PLXNB1_uc010hjx.1_Intron	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	850	Extracellular (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGTCCGCCTCGGGCAGCTCGCC	0.688000													4	6					0	0	6.4e-05	0	0
CELSR3	1951	broad.mit.edu	37	3	48697976	48697976	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:48697976G>A	uc003cul.2	-	1	2373	c.2092C>T	c.(2092-2094)CCT>TCT	p.P698S	CELSR3_uc003cuf.1_Missense_Mutation_p.P768S	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	698	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATCACAAAAGGAGTATCAGGT	0.542000													9	13					0	0	0.000274275	0	0
STAB1	23166	broad.mit.edu	37	3	52556956	52556956	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:52556956G>A	uc003dej.2	+	62	6984	c.6910G>A	c.(6910-6912)GAT>AAT	p.D2304N	STAB1_uc003dek.1_Missense_Mutation_p.D319N|STAB1_uc003del.2_Missense_Mutation_p.D191N	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2304	Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCGTGTGCAAGGTGTGTCCAC	0.612000													15	18					0	0	0.000308642	0	0
LRTM1	57408	broad.mit.edu	37	3	54958924	54958924	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:54958924G>A	uc003dhl.2	-	2	460	c.326C>T	c.(325-327)TCA>TTA	p.S109L	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	109	LRR 3.|Extracellular (Potential).					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		GGAAAGGAGTGAATTCTGGGT	0.468000													9	19					0	0	0.000442599	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55108195	55108195	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:55108195C>T	uc003dhf.2	+	38	3286	c.3238C>T	c.(3238-3240)CTT>TTT	p.L1080F		NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	1080	Helical; (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GACAGTCCTCCTTCTGCTCCC	0.507000													21	33					0	0	9.22233e-05	0	0
FLNB	2317	broad.mit.edu	37	3	58107012	58107012	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:58107012G>A	uc003djj.2	+	20	3073	c.2908G>A	c.(2908-2910)GGG>AGG	p.G970R	FLNB_uc010hne.2_Missense_Mutation_p.G970R|FLNB_uc003djk.2_Missense_Mutation_p.G970R|FLNB_uc010hnf.2_Missense_Mutation_p.G970R|FLNB_uc003djl.2_Missense_Mutation_p.G801R|FLNB_uc003djm.2_Missense_Mutation_p.G801R	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	970	Filamin 8.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TGATACCAGGGGGGCAGGAGG	0.577000													12	47					0	0	0.000219431	0	0
MYH15	22989	broad.mit.edu	37	3	108129532	108129532	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:108129532C>T	uc003dxa.1	-	32	4510	c.4453G>A	c.(4453-4455)GAA>AAA	p.E1485K		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1485	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GCCTGAACTTCCTTCTGAGAG	0.577000													8	21					0	0	0.000274275	0	0
GOLGB1	2804	broad.mit.edu	37	3	121414026	121414027	+	Nonsense_Mutation	DNP	CG	AT	AT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:121414026_121414027CG>AT	uc003eei.3	-	13	5454_5455	c.5328_5329CG>AT	c.(5326-5331)ACCGAG>ACATAG	p.E1777*	GOLGB1_uc010hrc.2_Nonsense_Mutation_p.E1782*|GOLGB1_uc003eej.3_Nonsense_Mutation_p.E1743*|GOLGB1_uc011bjm.1_Nonsense_Mutation_p.E1663*|GOLGB1_uc010hrd.1_Nonsense_Mutation_p.E1741*	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1777	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCATGTTTCTCGGTGGCCTCTA	0.411000													5	103					0	0	6.4e-05	0	0
SLC15A2	6565	broad.mit.edu	37	3	121613396	121613396	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:121613396C>T	uc003eep.2	+	1	226	c.73C>T	c.(73-75)CGA>TGA	p.R25*	SLC15A2_uc011bjn.1_Nonsense_Mutation_p.R25*	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	25					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GGTACCACCTCGACCACCTAG	0.502000													44	62					0	0	0.000147903	0	0
CASR	846	broad.mit.edu	37	3	121981094	121981094	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:121981094C>T	uc003eev.3	+	4	1584	c.1212C>T	c.(1210-1212)GTC>GTT	p.V404V	CASR_uc003eew.3_Silent_p.V404V	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	404	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TCAGCAGTGTCGAGACCCCTT	0.483000													5	19					0	0	8.12818e-05	0	0
MYLK	4638	broad.mit.edu	37	3	123452564	123452564	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:123452564C>T	uc003ego.2	-	10	1561	c.1279G>A	c.(1279-1281)GAA>AAA	p.E427K	MYLK_uc011bjw.1_Missense_Mutation_p.E427K|MYLK_uc003egp.2_Missense_Mutation_p.E427K|MYLK_uc003egq.2_Missense_Mutation_p.E427K|MYLK_uc003egr.2_Missense_Mutation_p.E427K|MYLK_uc003egs.2_Missense_Mutation_p.E251K	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	427	Ig-like C2-type 3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GTTTGATTTTCCTTGACCTCC	0.507000													12	58					0	0	0.000219431	0	0
KALRN	8997	broad.mit.edu	37	3	124437996	124437996	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:124437996C>T	uc003ehg.2	+	60	8767	c.8640C>T	c.(8638-8640)TTC>TTT	p.F2880F	KALRN_uc003ehk.2_Silent_p.F1183F	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2879	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TCTCCCCCTTCTTGGATGAGA	0.527000													13	16					0	0	0.00010058	0	0
ZXDC	79364	broad.mit.edu	37	3	126180782	126180782	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:126180782G>A	uc003eiv.2	-	6	1777	c.1723C>T	c.(1723-1725)CCC>TCC	p.P575S	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Missense_Mutation_p.P575S	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	575					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		AGGCTTGGGGGAATATCACTG	0.602000													10	13					0	0	0.000151284	0	0
CPA3	1359	broad.mit.edu	37	3	148614368	148614368	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:148614368C>T	uc003ewm.2	+	11	1180	c.1128C>T	c.(1126-1128)GCC>GCT	p.A376A		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	376					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			ACACATTTGCCTTTGAGCTCC	0.413000													32	31					0	0	0.000491102	0	0
MED12L	116931	broad.mit.edu	37	3	151105632	151105632	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:151105632C>A	uc003eyp.2	+	35	5056	c.5018C>A	c.(5017-5019)CCG>CAG	p.P1673Q	MED12L_uc011bnz.1_Missense_Mutation_p.P1533Q|MED12L_uc003eyy.1_Missense_Mutation_p.P836Q	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1673					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGGTGTCCCCGTGGGACTTG	0.527000													4	33					0.00024832	0.00378607	0.00024832	1	0
OTOL1	131149	broad.mit.edu	37	3	161221394	161221394	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:161221394C>T	uc011bpb.1	+	4	1098	c.1098C>T	c.(1096-1098)CTC>CTT	p.L366L		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	366	C1q.					collagen					0						AAAAGATTCTCTATAATGACC	0.473000													10	6					0	0	0.000442599	0	0
AP2M1	1173	broad.mit.edu	37	3	183900603	183900604	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:183900603_183900604CC>TT	uc011bqx.1	+	11	1277_1278	c.1120_1121CC>TT	c.(1120-1122)CCT>TTT	p.P374F	AP2M1_uc003fmw.2_Missense_Mutation_p.P372F|AP2M1_uc003fmx.2_Missense_Mutation_p.P302F|AP2M1_uc003fmy.2_Missense_Mutation_p.P372F|AP2M1_uc011bqy.1_Missense_Mutation_p.P244F|AP2M1_uc011bqz.1_Missense_Mutation_p.P190F	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	374	MHD.				axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGAGCTTCTGCCTACCAACGAC	0.480000													10	18					0	0	6.4e-05	0	0
EPHB3	2049	broad.mit.edu	37	3	184297636	184297636	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:184297636C>T	uc003foz.2	+	11	2523	c.2086C>T	c.(2086-2088)CGG>TGG	p.R696W		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	696	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			CAATATAATCCGGCTCGAGGG	0.582000													14	22					0	0	0.000219431	0	0
LPP	4026	broad.mit.edu	37	3	188242563	188242563	+	Silent	SNP	T	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:188242563T>C	uc003frs.1	+	5	663	c.417T>C	c.(415-417)CCT>CCC	p.P139P	LPP_uc011bsg.1_Silent_p.P139P|LPP_uc011bsi.1_Silent_p.P139P|LPP_uc003frt.2_Silent_p.P139P	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	139	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		CCTATAAGCCTCGGCCTCCAC	0.527000			T	HMGA2|MLL|C12orf9	lipoma|leukemia								18	54					0	0	0.000175454	0	0
TMEM44	93109	broad.mit.edu	37	3	194336417	194336417	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:194336417G>A	uc010hzn.2	-	8	1103	c.934C>T	c.(934-936)CTT>TTT	p.L312F	TMEM44_uc010hzm.2_5'UTR|TMEM44_uc003fuc.2_5'UTR|TMEM44_uc003fue.2_Missense_Mutation_p.L265F|TMEM44_uc003fud.2_Missense_Mutation_p.L265F|TMEM44_uc003fuf.2_Missense_Mutation_p.L265F|TMEM44_uc011bsv.1_Missense_Mutation_p.L265F|TMEM44_uc003fuh.1_RNA	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	312	Helical; (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		ACACACGAAAGGAAAATAATC	0.522000													49	84					0	0	0.000147903	0	0
ACAP2	23527	broad.mit.edu	37	3	195009893	195009893	+	Silent	SNP	A	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr3:195009893A>G	uc003fun.3	-	21	2372	c.2131T>C	c.(2131-2133)TTG>CTG	p.L711L		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	711	ANK 3.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						GCTATGCTCAAAGGGTCTTTC	0.363000													22	44					0	0	0.000586117	0	0
ZNF595	152687	broad.mit.edu	37	4	59361	59362	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:59361_59362CC>AA	uc003fzv.1	+	2	198_199	c.42_43CC>AA	c.(40-45)TCCCCT>TCAACT	p.P15T	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Missense_Mutation_p.P15T|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	15					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TAGAATTCTCCCCTGAAGAGTG	0.421000													10	206					0	0	6.4e-05	0	0
ZNF518B	85460	broad.mit.edu	37	4	10445685	10445685	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:10445685G>A	uc003gmn.2	-	3	2755	c.2268C>T	c.(2266-2268)ACC>ACT	p.T756T		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	756					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						CTCTGCTTTTGGTTTTCCTAT	0.453000													17	37					0	0	7.07596e-05	0	0
LGI2	55203	broad.mit.edu	37	4	25026478	25026478	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:25026478C>T	uc003grf.2	-	4	476	c.377G>A	c.(376-378)AGA>AAA	p.R126K		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	126	LRR 2.					extracellular region					0		Breast(46;0.173)				AAAGGCATTTCTTGAAATGGT	0.368000													16	30					0	0	0.000132079	0	0
SEPSECS	51091	broad.mit.edu	37	4	25125802	25125802	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:25125802G>A	uc003grg.2	-	11	1470	c.1257C>T	c.(1255-1257)TTC>TTT	p.F419F	SEPSECS_uc003gri.2_Silent_p.F418F|SEPSECS_uc003grh.2_Silent_p.F340F	NM_153825	NP_722547	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine)	419					selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding				0		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	TAAAGCCTCTGAAAGTATAGC	0.408000													7	30					0	0	0.000157383	0	0
TLR6	10333	broad.mit.edu	37	4	38829222	38829222	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:38829222G>A	uc003gtm.2	-	1	1939	c.1873C>T	c.(1873-1875)CGG>TGG	p.R625W	TLR6_uc010ifg.1_Missense_Mutation_p.R625W	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	625	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						GCCCTGCGCCGAGTCTGGGTC	0.512000													8	40					0	0	0.000274275	0	0
NSUN7	79730	broad.mit.edu	37	4	40763240	40763240	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:40763240G>A	uc003gvj.3	+	4	905	c.410G>A	c.(409-411)AGA>AAA	p.R137K	NSUN7_uc003gvh.2_Missense_Mutation_p.R137K|NSUN7_uc003gvi.3_Missense_Mutation_p.R137K	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						TTCCAAGATAGAAAATTTCAA	0.313000													53	73					0	0	0.000147903	0	0
ATP10D	57205	broad.mit.edu	37	4	47548647	47548647	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:47548647G>A	uc003gxk.1	+	10	1567	c.1403G>A	c.(1402-1404)AGG>AAG	p.R468K	ATP10D_uc003gxl.1_5'UTR|ATP10D_uc003gxj.3_Missense_Mutation_p.R453K	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	468	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						ACAGCCAGGAGGTTGGAGTCC	0.413000													9	42					0	0	0.000673444	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69097045	69097045	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:69097045C>T	uc003hdw.3	-	7	698	c.562G>A	c.(562-564)GGA>AGA	p.G188R		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	188	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GAGCTTTTTCCATTCACAATT	0.488000													9	36					0	0	0.000442599	0	0
ALB	213	broad.mit.edu	37	4	74279343	74279343	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:74279343C>T	uc003hgs.3	+	8	1123	c.1050C>T	c.(1048-1050)TTC>TTT	p.F350F	ALB_uc003hgw.3_Silent_p.F158F|ALB_uc011cbe.1_Silent_p.F29F|ALB_uc003hgt.3_Silent_p.F350F|ALB_uc010iii.2_Silent_p.F235F|ALB_uc003hgu.3_Silent_p.F200F|ALB_uc003hgv.3_Silent_p.F29F|ALB_uc011cbf.1_Silent_p.F240F|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Silent_p.F29F	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	350	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AGGATGTCTTCCTGGGCATGT	0.398000													9	33					0	0	0.000274275	0	0
HERC3	8916	broad.mit.edu	37	4	89579585	89579585	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:89579585C>T	uc003hrw.1	+	10	1255	c.1089C>T	c.(1087-1089)ATC>ATT	p.I363I	HERC3_uc011cdn.1_Silent_p.I245I|HERC3_uc011cdo.1_5'UTR	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	363	RCC1 7.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		AATATCATATCGTTAAGCAGA	0.338000													9	42					0	0	0.00010058	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95170890	95170891	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:95170890_95170891CC>AA	uc003htc.3	+	7	1046_1047	c.791_792CC>AA	c.(790-792)CCC>CAA	p.P264Q	SMARCAD1_uc003htb.3_Missense_Mutation_p.P264Q|SMARCAD1_uc003htd.3_Missense_Mutation_p.P264Q|SMARCAD1_uc010ila.2_Missense_Mutation_p.P127Q	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	264	CUE 2.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		AAGGAATTTCCCAATTTTGATA	0.332000													9	103					0	0	6.4e-05	0	0
EDNRA	1909	broad.mit.edu	37	4	148463717	148463717	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr4:148463717G>A	uc003iky.2	+	8	1923	c.1231G>A	c.(1231-1233)GAT>AAT	p.D411N	EDNRA_uc011cid.1_Missense_Mutation_p.D186N|EDNRA_uc010ipf.1_RNA|EDNRA_uc010ipg.1_Missense_Mutation_p.D302N	NM_001957	NP_001948	P25101	EDNRA_HUMAN	endothelin receptor type A isoform a precursor	411	Cytoplasmic (Potential).				activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|breast(1)	2	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	GAAGAACCACGATCAAAACAA	0.522000													10	16					0	0	0.000442599	0	0
DNAH5	1767	broad.mit.edu	37	5	13769652	13769652	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:13769652C>T	uc003jfd.2	-	57	9720	c.9678G>A	c.(9676-9678)GCG>GCA	p.A3226A	DNAH5_uc003jfc.2_5'Flank	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3226	Stalk (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCTTTTCTTTCGCTTCCAGTT	0.433000									Kartagener_syndrome				47	68					0	0	0.000147903	0	0
IL7R	3575	broad.mit.edu	37	5	35873648	35873648	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:35873648G>A	uc003jjs.2	+	5	693	c.604G>A	c.(604-606)GAG>AAG	p.E202K	IL7R_uc011coo.1_Missense_Mutation_p.E202K|IL7R_uc011cop.1_Intron	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	202	Extracellular (Potential).|Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AGCAATGTATGAGATTAAAGT	0.418000													9	34					0	0	0.000274275	0	0
LIFR	3977	broad.mit.edu	37	5	38530715	38530715	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:38530715G>A	uc010ive.1	-	2	367	c.35C>T	c.(34-36)TCC>TTC	p.S12F	LIFR_uc003jli.2_Missense_Mutation_p.S12F	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	12					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					CACCATCCAGGATGGTCGTTT	0.388000			T	PLAG1	salivary adenoma								29	37					0	0	0.000491102	0	0
OXCT1	5019	broad.mit.edu	37	5	41842835	41842835	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:41842835C>T	uc003jmn.2	-	6	944	c.613G>A	c.(613-615)GGG>AGG	p.G205R		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	205					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	GCAAAATCCCCTGTAATTGCT	0.443000													44	78					0	0	0.000147903	0	0
C5orf28	64417	broad.mit.edu	37	5	43446579	43446579	+	Silent	SNP	A	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:43446579A>G	uc003jny.2	-	3	536	c.393T>C	c.(391-393)ACT>ACC	p.T131T	C5orf28_uc003jnv.3_Silent_p.T131T|C5orf28_uc003jnx.2_Silent_p.T131T	NM_022483	NP_071928	Q0VDI3	CE028_HUMAN	hypothetical protein LOC64417	131	Helical; (Potential).					integral to membrane					0	Lung NSC(6;2.07e-05)					AAAGGTGCATAGTAAATTTCA	0.448000													18	39					0	0	0.000175454	0	0
F2RL2	2151	broad.mit.edu	37	5	75913780	75913780	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:75913780G>C	uc003kem.2	-	2	937	c.752C>G	c.(751-753)ACT>AGT	p.T251S	IQGAP2_uc003kek.2_Intron|IQGAP2_uc010izv.2_Intron|IQGAP2_uc011csv.1_Intron|IQGAP2_uc003kel.2_Intron|F2RL2_uc011csw.1_Missense_Mutation_p.T229S	NM_004101	NP_004092	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	251	Extracellular (Potential).				platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity			skin(2)|ovary(1)	3		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		GGACTCGCAAGTGTTGTGAAC	0.413000													8	32					0	0	0.000157383	0	0
HOMER1	9456	broad.mit.edu	37	5	78672008	78672008	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:78672008G>A	uc003kfy.2	-	9	1992	c.889C>T	c.(889-891)CGG>TGG	p.R297W	HOMER1_uc010jab.2_3'UTR|HOMER1_uc010jac.2_Missense_Mutation_p.R167W|HOMER1_uc010jad.2_Missense_Mutation_p.R123W	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	297	Potential.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		TCTTTGTTCCGAATTTCTACT	0.368000													22	42					0	0	0.000586117	0	0
SLC25A46	91137	broad.mit.edu	37	5	110077790	110077790	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:110077790G>A	uc003koz.2	+	2	393	c.326G>A	c.(325-327)AGT>AAT	p.S109N	SLC25A46_uc011cvi.1_Missense_Mutation_p.S18N	NM_138773	NP_620128	Q96AG3	S2546_HUMAN	solute carrier family 25, member 46	109	Solcar 1.|Helical; Name=1; (Potential).				transport	integral to membrane|mitochondrial inner membrane					0		all_cancers(142;0.00203)|all_epithelial(76;4.52e-05)|Prostate(80;0.0115)|Colorectal(57;0.0676)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;2.58e-09)|Epithelial(69;7.29e-08)|all cancers(49;9.35e-06)|COAD - Colon adenocarcinoma(37;0.211)		GGACTTGCAAGGTAATGTTTT	0.244000													16	50					0	0	9.7654e-05	0	0
AQPEP	206338	broad.mit.edu	37	5	115319054	115319054	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:115319054C>T	uc003kro.2	+	2	930	c.766C>T	c.(766-768)CTG>TTG	p.L256L	AQPEP_uc003krp.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	256	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TGAGCCAGCTCTGAAGGCAAC	0.398000													20	14					0	0	0.000132079	0	0
FAM170A	340069	broad.mit.edu	37	5	118970376	118970376	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:118970376G>A	uc003ksm.2	+	3	1143	c.933G>A	c.(931-933)AGG>AGA	p.R311R	FAM170A_uc003ksl.2_Intron|FAM170A_uc003ksn.2_Silent_p.R311R|FAM170A_uc003kso.2_Silent_p.R264R	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	311						intracellular	zinc ion binding			skin(1)	1						TTGGCCTGAGGAGATCCTGGA	0.348000													22	35					0	0	9.22233e-05	0	0
PRR16	51334	broad.mit.edu	37	5	120021677	120021677	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:120021677C>T	uc003ksq.2	+	2	351	c.188C>T	c.(187-189)TCT>TTT	p.S63F	PRR16_uc003ksp.2_Missense_Mutation_p.S40F|PRR16_uc003ksr.2_5'UTR	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	63	Potential.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		ACCCTGACCTCTGACCTACAG	0.438000													17	34					0	0	0.000566183	0	0
PCDHB17	54661	broad.mit.edu	37	5	140536860	140536860	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:140536860G>A	uc003lis.2	+	1	1281	c.1281G>A	c.(1279-1281)GGG>GGA	p.G427G		NR_001280				SubName: Full=Protocadherin-psi1;												0						CAGACTTGGGGACACCCAGGC	0.517000													8	18					0	0	0.000274275	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573489	140573489	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:140573489C>T	uc003lix.2	+	1	1538	c.1364C>T	c.(1363-1365)TCC>TTC	p.S455F		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	455	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCCAAACCTCCTACACCCTG	0.617000													17	26					0	0	0.000175454	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774082	140774082	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:140774082C>T	uc003lkd.1	+	1	2600	c.1702C>T	c.(1702-1704)CCC>TCC	p.P568S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.P568S	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	568	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCGCCCTCCCCACAGACGG	0.667000													14	41					0	0	0.000308642	0	0
GLRA1	2741	broad.mit.edu	37	5	151239414	151239414	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:151239414G>A	uc003lut.2	-	4	695	c.408C>T	c.(406-408)TTC>TTT	p.F136F	GLRA1_uc003lur.2_Silent_p.F136F|GLRA1_uc003lus.2_Silent_p.F53F	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	136	Extracellular (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGATCTCATGGAAGTGGGCCC	0.522000													21	19					0	0	0.000132079	0	0
HAVCR1	26762	broad.mit.edu	37	5	156456847	156456847	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:156456847G>A	uc010jij.1	-	9	1177	c.992C>T	c.(991-993)TCA>TTA	p.S331L	HAVCR1_uc011ddl.1_Missense_Mutation_p.H151Y|HAVCR1_uc003lwi.2_Missense_Mutation_p.S331L	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	326	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCTGCTAAATGAAACACTGTA	0.353000													84	126					0	0	0.000147903	0	0
GPRIN1	114787	broad.mit.edu	37	5	176025032	176025033	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr5:176025032_176025033GG>AA	uc003meo.1	-	2	1978_1979	c.1803_1804CC>TT	c.(1801-1806)ATCCCA>ATTTCA	p.P602S		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	602						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTTCCCTCTGGGATAGCTTCTG	0.569000													16	15					0	0	6.4e-05	0	0
PIP5K1P1	206426	broad.mit.edu	37	6	7987825	7987825	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:7987825G>A	uc003mxx.3	+	1	1491	c.1056G>A	c.(1054-1056)ATG>ATA	p.M352I	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						CCACAGCCATGGAATTCATCC	0.532000													5	6					0	0	0.000602214	0	0
FAM65B	9750	broad.mit.edu	37	6	24874004	24874004	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:24874004G>A	uc003neo.1	-	3	301	c.125C>T	c.(124-126)TCC>TTC	p.S42F	FAM65B_uc011djs.1_Missense_Mutation_p.S71F|FAM65B_uc011dju.1_Missense_Mutation_p.S76F|FAM65B_uc003nep.2_Missense_Mutation_p.S42F|FAM65B_uc011djt.1_Missense_Mutation_p.S42F	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	42					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						GAGAGCGGAGGAATTTTCAAT	0.408000													12	44					0	0	0.000151284	0	0
MDC1	9656	broad.mit.edu	37	6	30680224	30680224	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:30680224C>T	uc003nrg.3	-	5	1935	c.1495G>A	c.(1495-1497)GTG>ATG	p.V499M	MDC1_uc003nrf.3_Missense_Mutation_p.V153M|MDC1_uc011dmp.1_Missense_Mutation_p.V371M|MDC1_uc003nrh.1_Missense_Mutation_p.V371M|MDC1_uc003nri.2_Missense_Mutation_p.V499M	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	499	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TCTGCTTCCACACTGTCATCA	0.502000								Other_conserved_DNA_damage_response_genes					24	36					0	0	0.000147802	0	0
ZNF76	7629	broad.mit.edu	37	6	35258483	35258483	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:35258483C>T	uc003oki.1	+	7	820	c.615C>T	c.(613-615)GCC>GCT	p.A205A	ZNF76_uc011dsy.1_Silent_p.A205A|ZNF76_uc011dsz.1_Silent_p.A205A|ZNF76_uc003okj.1_Silent_p.A205A	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	205	C2H2-type 2.				regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTGGAAAGGCCTTTGCCACAG	0.547000													11	32					0	0	0.000219431	0	0
CD2AP	23607	broad.mit.edu	37	6	47576971	47576971	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:47576971C>T	uc003oyw.2	+	16	2201	c.1745C>T	c.(1744-1746)TCC>TTC	p.S582F		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	582	Potential.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			AAAAAAAATTCCCTGGATGAA	0.393000													19	33					0	0	0.000175454	0	0
ZNF451	26036	broad.mit.edu	37	6	57012296	57012296	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:57012296C>T	uc003pdm.1	+	10	1637	c.1413C>T	c.(1411-1413)ACC>ACT	p.T471T	ZNF451_uc003pdl.2_Silent_p.T471T|ZNF451_uc003pdn.1_Silent_p.T471T|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Silent_p.T471T	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	471					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TAGTTAAAACCTGGTTCTGTG	0.383000													12	24					0	0	0.00010058	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62887095	62887095	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:62887095G>A	uc003peg.2	-	2	461	c.214C>T	c.(214-216)CCA>TCA	p.P72S		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	72	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		AGTACCTTTGGATACTGCTTG	0.279000													9	26					0	0	0.00010058	0	0
BAI3	577	broad.mit.edu	37	6	70049369	70049369	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:70049369C>T	uc003pev.3	+	26	3880	c.3432C>T	c.(3430-3432)GTC>GTT	p.V1144V	BAI3_uc010kak.2_Silent_p.V1144V|BAI3_uc011dxx.1_Silent_p.V350V|BAI3_uc003pex.1_Silent_p.V274V	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1144	Helical; Name=7; (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TTGTTATAGTCATGGTCCACT	0.403000													20	49					0	0	0.000175454	0	0
RIMS1	22999	broad.mit.edu	37	6	72678710	72678710	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:72678710G>A	uc003pga.2	+	2	266	c.189G>A	c.(187-189)AAG>AAA	p.K63K		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	63	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				ACATGGCGAAGCCTGCTGCCT	0.448000													5	34					0	0	8.12818e-05	0	0
KCNQ5	56479	broad.mit.edu	37	6	73751701	73751701	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:73751701C>T	uc003pgk.2	+	3	879	c.532C>T	c.(532-534)CGA>TGA	p.R178*	KCNQ5_uc003pgj.3_Nonsense_Mutation_p.R178*|KCNQ5_uc011dyh.1_Nonsense_Mutation_p.R178*|KCNQ5_uc011dyi.1_Nonsense_Mutation_p.R178*|KCNQ5_uc010kat.2_Nonsense_Mutation_p.R178*|KCNQ5_uc011dyj.1_Nonsense_Mutation_p.R178*|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	178					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GTTCATCATTCGAATCTGGTC	0.423000													61	58					0	0	0.000147903	0	0
MDN1	23195	broad.mit.edu	37	6	90363971	90363971	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:90363971C>T	uc003pnn.1	-	93	15689	c.15573G>A	c.(15571-15573)ATG>ATA	p.M5191I		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5191					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CCTCTGTGTCCATAAGGGTGT	0.532000													60	61					0	0	0.000147903	0	0
MCHR2	84539	broad.mit.edu	37	6	100395747	100395747	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:100395747G>A	uc003pqh.1	-	3	598	c.283C>T	c.(283-285)CGA>TGA	p.R95*	MCHR2_uc003pqi.1_Nonsense_Mutation_p.R95*	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	95	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		TCTCCCCCTCGGGCCCATTGG	0.488000													6	23					0	0	3.59834e-05	0	0
SIM1	6492	broad.mit.edu	37	6	100841753	100841753	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:100841753G>A	uc003pqj.3	-	10	1387	c.1180C>T	c.(1180-1182)CAC>TAC	p.H394Y	SIM1_uc010kcu.2_Missense_Mutation_p.H394Y	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	394	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CTTTCTGTGTGAAATCCCGAA	0.478000													11	10					0	0	0.000151284	0	0
AKD1	221264	broad.mit.edu	37	6	109850220	109850220	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:109850220C>T	uc003ptn.2	-	29	3704	c.3627G>A	c.(3625-3627)AGG>AGA	p.R1209R	AKD1_uc011eat.1_Silent_p.R288R	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1209					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						TTACCTCCCTCCTTTTTTTAT	0.184000													6	25					0	0	8.12818e-05	0	0
DSE	29940	broad.mit.edu	37	6	116752308	116752308	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:116752308C>T	uc003pws.2	+	4	1056	c.862C>T	c.(862-864)CCG>TCG	p.P288S	DSE_uc011ebg.1_Missense_Mutation_p.P307S|DSE_uc003pwt.2_Missense_Mutation_p.P288S|DSE_uc003pwu.2_5'Flank	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	288					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		CTTTGGCCATCCGTGGCTTAA	0.413000													13	26					0	0	0.00010058	0	0
ROS1	6098	broad.mit.edu	37	6	117704553	117704553	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:117704553G>A	uc003pxp.1	-	16	2622	c.2423C>T	c.(2422-2424)TCA>TTA	p.S808L	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	808	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCTTTCCACTGAATAGAGTGT	0.433000			T	GOPC|ROS1	glioblastoma|NSCLC								12	30					0	0	0.000151284	0	0
HIVEP2	3097	broad.mit.edu	37	6	143090952	143090952	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:143090952G>A	uc003qjd.2	-	5	5667	c.4924C>T	c.(4924-4926)CGG>TGG	p.R1642W		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1642					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GTTGTTGTCCGCAGACTGGGG	0.502000													8	5					0	0	0.000157383	0	0
PLAGL1	5325	broad.mit.edu	37	6	144263496	144263496	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:144263496C>T	uc003qjv.2	-	3	1723	c.457G>A	c.(457-459)GAA>AAA	p.E153K	PLAGL1_uc003qjx.2_Missense_Mutation_p.E153K|PLAGL1_uc003qjy.2_Missense_Mutation_p.E153K|PLAGL1_uc010khl.2_Missense_Mutation_p.E153K|PLAGL1_uc010khm.2_Missense_Mutation_p.E153K|PLAGL1_uc003qjz.2_Missense_Mutation_p.E153K|PLAGL1_uc003qka.2_Missense_Mutation_p.E153K|PLAGL1_uc003qkb.2_Missense_Mutation_p.E101K|PLAGL1_uc003qkc.2_Missense_Mutation_p.E153K|PLAGL1_uc003qkd.2_Missense_Mutation_p.E101K|PLAGL1_uc003qke.2_Missense_Mutation_p.E153K|PLAGL1_uc003qkf.2_Missense_Mutation_p.E153K|PLAGL1_uc003qkg.2_Missense_Mutation_p.E101K|PLAGL1_uc003qkh.2_Missense_Mutation_p.E153K|PLAGL1_uc003qki.2_Missense_Mutation_p.E101K|PLAGL1_uc003qkj.2_Missense_Mutation_p.E153K|PLAGL1_uc003qkk.2_Missense_Mutation_p.E101K|PLAGL1_uc003qkl.2_Missense_Mutation_p.E101K|PLAGL1_uc003qkm.2_Missense_Mutation_p.E153K|PLAGL1_uc010khn.2_Missense_Mutation_p.E153K|PLAGL1_uc003qkn.2_Missense_Mutation_p.E101K|PLAGL1_uc003qko.2_Missense_Mutation_p.E153K|PLAGL1_uc003qkp.2_Missense_Mutation_p.E101K|PLAGL1_uc003qjw.2_Missense_Mutation_p.E101K	NM_002656	NP_002647	Q9UM63	PLAL1_HUMAN	pleiomorphic adenoma gene-like 1 isoform 1	153					cell cycle arrest|induction of apoptosis|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.74e-07)|GBM - Glioblastoma multiforme(68;0.0885)		TGCTTCTTTTCCTTGGTTCCG	0.592000											OREG0017707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	70					0	0	9.22233e-05	0	0
KIF25	3834	broad.mit.edu	37	6	168439243	168439243	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:168439243G>A	uc003qwk.1	+	5	590	c.328G>A	c.(328-330)GAA>AAA	p.E110K	KIF25_uc003qwl.1_Missense_Mutation_p.E110K	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	110	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GCTCATTTTGGAAAATACCTC	0.438000													6	19					0	0	0.000157383	0	0
SDK1	221935	broad.mit.edu	37	7	4201469	4201469	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:4201469C>T	uc003smx.2	+	32	4920	c.4781C>T	c.(4780-4782)TCT>TTT	p.S1594F	SDK1_uc010kso.2_Missense_Mutation_p.S870F|SDK1_uc003smy.2_Missense_Mutation_p.S81F	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1594	Fibronectin type-III 10.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACCACGTCCTCTGTCCTGATA	0.562000													12	21					0	0	0.000422831	0	0
COL28A1	340267	broad.mit.edu	37	7	7421240	7421240	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:7421240C>T	uc003src.1	-	28	2257	c.2140G>A	c.(2140-2142)GAA>AAA	p.E714K	COL28A1_uc011jxe.1_Missense_Mutation_p.E397K	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	714					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GGTCCTTGTTCCCCCTACATA	0.468000													44	96					0	0	0.000147903	0	0
HOXA2	3199	broad.mit.edu	37	7	27140752	27140753	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:27140752_27140753CC>TT	uc003syh.2	-	2	998_999	c.723_724GG>AA	c.(721-726)GGGGCC>GGAACC	p.A242T		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	242						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						TCCAGAAGGGCCCCAGAGACGC	0.525000													15	17					0	0	6.4e-05	0	0
HOXA3	3200	broad.mit.edu	37	7	27150085	27150085	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:27150085C>T	uc011jzl.1	-	2	375	c.175G>A	c.(175-177)GGG>AGG	p.G59R	HOXA3_uc011jzk.1_Intron|HOXA3_uc003syk.2_Missense_Mutation_p.G59R	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	59					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						GGGTGGCCCCCGGCGCTGGAG	0.642000													4	10					0	0	0.00024832	0	0
PDE1C	5137	broad.mit.edu	37	7	31904624	31904624	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:31904624G>A	uc003tcm.1	-	7	1151	c.682C>T	c.(682-684)CAT>TAT	p.H228Y	PDE1C_uc003tcn.1_Missense_Mutation_p.H228Y|PDE1C_uc003tco.1_Missense_Mutation_p.H288Y|PDE1C_uc003tcr.2_Missense_Mutation_p.H228Y|PDE1C_uc003tcs.2_Missense_Mutation_p.H228Y	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	228	Catalytic (By similarity).	Proton donor (By similarity).			activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			ATTAAGTTATGGTAAGGATTT	0.458000													8	18					0	0	0.000274275	0	0
TBX20	57057	broad.mit.edu	37	7	35244193	35244193	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:35244193C>T	uc011kas.1	-	7	903	c.892G>A	c.(892-894)GAA>AAA	p.E298K		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	298						nucleus	DNA binding			central_nervous_system(1)	1						TCCACACTTTCCCTAGGTTAG	0.438000													7	9					0	0	0.000442599	0	0
INHBA	3624	broad.mit.edu	37	7	41729763	41729763	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:41729763G>A	uc003thq.2	-	2	1001	c.766C>T	c.(766-768)CTC>TTC	p.L256F	INHBA_uc003thr.2_Missense_Mutation_p.L256F	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	256					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						tTGCCCAGGAGAACCAAGCTG	0.358000										TSP Lung(11;0.080)			9	17					0	0	0.000274275	0	0
GLI3	2737	broad.mit.edu	37	7	42004782	42004783	+	Silent	DNP	GG	AA	AA	rs145618226		TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:42004782_42004783GG>AA	uc011kbh.1	-	15	3979_3980	c.3888_3889CC>TT	c.(3886-3891)GGCCTG>GGTTTG	p.1296_1297GL>GL	GLI3_uc011kbg.1_Silent_p.1237_1238GL>GL	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1296_1297					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GCTACCGGCAGGCCGAAATTCA	0.634000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				9	17					0	0	6.4e-05	0	0
GLI3	2737	broad.mit.edu	37	7	42006170	42006170	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:42006170G>A	uc011kbh.1	-	15	2592	c.2501C>T	c.(2500-2502)TCT>TTT	p.S834F	GLI3_uc011kbg.1_Missense_Mutation_p.S775F	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	834					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GTCCACCCCAGAGAGGTCGCT	0.617000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				14	26					0	0	0.000219431	0	0
MYO1G	64005	broad.mit.edu	37	7	45005409	45005409	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:45005409G>A	uc003tmh.2	-	17	2352	c.2208C>T	c.(2206-2208)ATC>ATT	p.I736I	MYO1G_uc003tmf.2_Silent_p.I179I|MYO1G_uc003tmg.2_Silent_p.I498I|MYO1G_uc010kym.2_Silent_p.I621I	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	736	IQ.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						TGATGGTGTAGATAGCCCTCA	0.652000													10	18					0	0	6.40141e-05	0	0
EGFR	1956	broad.mit.edu	37	7	55211060	55211060	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:55211060G>T	uc003tqk.2	+	3	549	c.303G>T	c.(301-303)TTG>TTT	p.L101F	EGFR_uc003tqh.2_Missense_Mutation_p.L101F|EGFR_uc003tqi.2_Missense_Mutation_p.L101F|EGFR_uc003tqj.2_Missense_Mutation_p.L101F|EGFR_uc010kzg.1_Missense_Mutation_p.L101F|EGFR_uc011kco.1_Missense_Mutation_p.L48F	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	101	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GAATTCCTTTGGAAAACCTGC	0.418000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			33	57					1.49673e-21	2.30624e-20	0.000228196	1	0
ZNF716	441234	broad.mit.edu	37	7	57510016	57510016	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:57510016C>T	uc011kdi.1	+	1	134	c.22C>T	c.(22-24)CCT>TCT	p.P8S		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						ACCGGGACCCCCTGGAAGCCG	0.562000													9	11					0	0	6.40141e-05	0	0
ZNF679	168417	broad.mit.edu	37	7	63720720	63720720	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:63720720C>T	uc003tsx.2	+	3	430	c.161C>T	c.(160-162)TCC>TTC	p.S54F		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	54	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						AACCTGGTCTCCCTGGGTGAG	0.368000													42	57					0	0	0.000147903	0	0
ZNF273	10793	broad.mit.edu	37	7	64388822	64388822	+	Silent	SNP	A	G	G			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:64388822A>G	uc003tto.2	+	4	1192	c.1116A>G	c.(1114-1116)AAA>AAG	p.K372K	ZNF273_uc003ttl.2_Silent_p.K307K|ZNF273_uc003ttn.2_Silent_p.K307K	NM_021148	NP_066971	Q14593	ZN273_HUMAN	zinc finger protein 273	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(55;0.0295)|all_lung(88;0.0691)				CTGGAGAGAAACCCTACAAAT	0.383000													3	42					0	0	0.00024832	0	0
PCLO	27445	broad.mit.edu	37	7	82584366	82584366	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:82584366G>A	uc003uhx.2	-	5	6192	c.5903C>T	c.(5902-5904)TCG>TTG	p.S1968L	PCLO_uc003uhv.2_Missense_Mutation_p.S1968L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1899					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCCATCTACCGATCCATTGTA	0.363000													56	57					0	0	0.000147903	0	0
PCLO	27445	broad.mit.edu	37	7	82584459	82584459	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:82584459C>T	uc003uhx.2	-	5	6099	c.5810G>A	c.(5809-5811)CGA>CAA	p.R1937Q	PCLO_uc003uhv.2_Missense_Mutation_p.R1937Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1868					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CACTTCATCTCGTTCATTTGC	0.363000													36	42					0	0	0.000228196	0	0
ABCB1	5243	broad.mit.edu	37	7	87135224	87135224	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:87135224C>T	uc003uiz.1	-	28	4043	c.3625G>A	c.(3625-3627)GAA>AAA	p.E1209K	ABCB1_uc011khc.1_Missense_Mutation_p.E1145K	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	1209	Cytoplasmic (Potential).|ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTTTCACTTTCTGTATCCAGA	0.418000													18	27					0	0	0.000132079	0	0
STEAP2	261729	broad.mit.edu	37	7	89861715	89861715	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:89861715G>A	uc003ujz.2	+	5	1643	c.1250G>A	c.(1249-1251)CGA>CAA	p.R417Q	STEAP2_uc010len.2_Missense_Mutation_p.R417Q|STEAP2_uc003uka.2_Missense_Mutation_p.R417Q|STEAP2_uc003ukb.2_Missense_Mutation_p.R417Q|STEAP2_uc003ukc.2_Intron|STEAP2_uc003ukd.2_Missense_Mutation_p.R417Q	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	417					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					GGATGGAAACGAGCTTTTGAG	0.368000													9	16					0	0	0.000274275	0	0
PON1	5444	broad.mit.edu	37	7	94947640	94947640	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:94947640C>T	uc003uns.2	-	2	237	c.140G>A	c.(139-141)GGA>GAA	p.G47E	PON1_uc011kih.1_Intron	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	47					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	CATACCGATTCCTTTAACTAA	0.388000													14	59					0	0	0.000422831	0	0
TMEM130	222865	broad.mit.edu	37	7	98452871	98452871	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:98452871G>A	uc003upo.2	-	5	984	c.795C>T	c.(793-795)TTC>TTT	p.F265F	TMEM130_uc011kiq.1_Silent_p.F246F|TMEM130_uc011kir.1_Silent_p.F265F|TMEM130_uc003upn.2_Silent_p.F163F	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	265	Extracellular (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ACCTCCCCAGGAAGTTCAAGG	0.572000													12	15					0	0	0.00010058	0	0
MCM7	4176	broad.mit.edu	37	7	99697359	99697359	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:99697359C>T	uc003usw.1	-	3	639	c.129G>A	c.(127-129)CGG>CGA	p.R43R	MCM7_uc003usv.1_5'UTR|MCM7_uc003usx.1_5'UTR|AP4M1_uc011kjg.1_5'Flank|AP4M1_uc010lgl.1_5'Flank|AP4M1_uc003utb.3_5'Flank|AP4M1_uc003utc.3_5'Flank|AP4M1_uc010lgm.2_5'Flank|AP4M1_uc003utd.2_5'Flank|AP4M1_uc011kjh.1_5'Flank|AP4M1_uc003ute.3_5'Flank|AP4M1_uc003utf.3_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	43					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	CCACCTGTTCCCGATGAGCCA	0.532000													10	24					0	0	6.40141e-05	0	0
PNPLA8	50640	broad.mit.edu	37	7	108154703	108154704	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:108154703_108154704CG>AT	uc003vff.1	-	5	1497_1498	c.1090_1091CG>AT	c.(1090-1092)CGG>ATG	p.R364M	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Missense_Mutation_p.R364M|PNPLA8_uc003vfi.1_Missense_Mutation_p.R264M|PNPLA8_uc003vfj.1_Missense_Mutation_p.R364M|PNPLA8_uc003vfk.1_Missense_Mutation_p.R264M	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	364					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						AACTAATGCCCGGGTCCTGTTA	0.356000													8	172					0	0	6.4e-05	0	0
LMOD2	442721	broad.mit.edu	37	7	123302492	123302492	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:123302492G>A	uc003vky.2	+	2	1009	c.852G>A	c.(850-852)GGG>GGA	p.G284G		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	284						cytoskeleton	actin binding|tropomyosin binding				0						CGGGAAAGGGGATCCTGGCCA	0.537000													41	15					0	0	0.000589545	0	0
COPG2	26958	broad.mit.edu	37	7	130295969	130295970	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:130295969_130295970CC>AA	uc003vqh.1	-	9	681_682	c.591_592GG>TT	c.(589-594)TTGGGA>TTTTGA	p.197_198LG>F*		NM_012133	NP_036265	Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2	197_198					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity				0	Melanoma(18;0.0435)					TACAGGACTCCCAATGCATGGT	0.342000													10	293					0	0	6.4e-05	0	0
DGKI	9162	broad.mit.edu	37	7	137271890	137271890	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:137271890G>A	uc003vtt.2	-	13	1379	c.1378C>T	c.(1378-1380)CCT>TCT	p.P460S	DGKI_uc003vtu.2_Missense_Mutation_p.P160S	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	460	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GTCCCCAGAGGAAGGACCCCC	0.567000													7	9					0	0	8.12818e-05	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				38	19					0	0	0.000270559	0	0
CLCN1	1180	broad.mit.edu	37	7	143018516	143018516	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:143018516G>C	uc003wcr.1	+	4	579	c.492G>C	c.(490-492)TGG>TGC	p.W164C	CLCN1_uc011ktc.1_5'UTR|CLCN1_uc003wcs.1_RNA|CLCN1_uc010lox.1_RNA|CLCN1_uc010loy.1_Missense_Mutation_p.W12C	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	164	Helical; (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					TCCTGGTCTGGGTCACCTTCC	0.597000													3	27					0	0	0.00024832	0	0
MLL3	58508	broad.mit.edu	37	7	151880143	151880144	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:151880143_151880144GG>TT	uc003wla.2	-	35	5399_5400	c.5180_5181CC>AA	c.(5179-5181)CCC>CAA	p.P1727Q	MLL3_uc003wkz.2_Missense_Mutation_p.P788Q	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1727	Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TACGAGAGCTGGGATCAATGCT	0.371000			N		medulloblastoma								12	345					0	0	6.4e-05	0	0
NCAPG2	54892	broad.mit.edu	37	7	158448069	158448069	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:158448069C>A	uc003wnv.1	-	20	2612	c.2467G>T	c.(2467-2469)GGT>TGT	p.G823C	NCAPG2_uc010lqu.1_Missense_Mutation_p.G615C|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Missense_Mutation_p.G823C|NCAPG2_uc011kwe.1_Missense_Mutation_p.G823C|NCAPG2_uc011kwc.1_Missense_Mutation_p.G324C|NCAPG2_uc011kwd.1_Missense_Mutation_p.G266C	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	823					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		CAGTGGAGACCAAAGGCTCGC	0.522000													8	112					0.000274275	0.00417085	0.000274275	1	0
ZNF596	169270	broad.mit.edu	37	8	195476	195476	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr8:195476T>C	uc003wot.2	+	6	917	c.629T>C	c.(628-630)CTT>CCT	p.L210P	ZNF596_uc003wou.2_Missense_Mutation_p.L109P|ZNF596_uc003wov.2_Missense_Mutation_p.L210P|ZNF596_uc003wow.2_Missense_Mutation_p.L210P	NM_173539	NP_775810	Q8TC21	ZN596_HUMAN	zinc finger protein 596	210	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)		AATTCTAATCTTAGGCGACAT	0.423000													18	53					0	0	0.000132079	0	0
Unknown	0	broad.mit.edu	37	8	26237032	26237032	+	RNA	SNP	T	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr8:26237032T>C	uc003xew.2	-	2		c.2917A>G								Homo sapiens cDNA clone IMAGE:4826633.																		TGTTTTTTCTTCTCTTTACTT	0.398000													23	29					0	0	0.000375601	0	0
FNTA	2339	broad.mit.edu	37	8	42938323	42938323	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr8:42938323G>A	uc003xps.2	+	7	893	c.845G>A	c.(844-846)GGG>GAG	p.G282E	FNTA_uc003xpt.2_Missense_Mutation_p.G191E|FNTA_uc003xpu.2_Missense_Mutation_p.G215E|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	282	PFTA 5.				cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			TATTTGAAAGGGTAAGAGGTT	0.284000													28	190					0	0	0.000339439	0	0
ST18	9705	broad.mit.edu	37	8	53073958	53073958	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr8:53073958C>T	uc003xqz.2	-	9	1727	c.1571G>A	c.(1570-1572)CGA>CAA	p.R524Q	ST18_uc011ldq.1_Missense_Mutation_p.R171Q|ST18_uc011ldr.1_Missense_Mutation_p.R489Q|ST18_uc011lds.1_Missense_Mutation_p.R429Q|ST18_uc003xra.2_Missense_Mutation_p.R524Q|ST18_uc003xrb.2_Missense_Mutation_p.R524Q	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	524						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGGTGTTTTTCGTCCTTGCAC	0.438000													33	32					0	0	0.000132358	0	0
PREX2	80243	broad.mit.edu	37	8	68982109	68982110	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr8:68982109_68982110CC>AA	uc003xxv.1	+	13	1510_1511	c.1483_1484CC>AA	c.(1483-1485)CCA>AAA	p.P495K	PREX2_uc003xxu.1_Missense_Mutation_p.P495K|PREX2_uc011lez.1_Missense_Mutation_p.P430K	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	495	DEP 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CCTTTTTACTCCAGTGATAAGG	0.327000													8	194					0	0	6.4e-05	0	0
SNX31	169166	broad.mit.edu	37	8	101589289	101589290	+	Missense_Mutation	DNP	CG	AT	AT	rs149337394	byFrequency	TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr8:101589289_101589290CG>AT	uc003yjr.2	-	13	1335_1336	c.1184_1185CG>AT	c.(1183-1185)CCG>CAT	p.P395H	SNX31_uc011lha.1_Missense_Mutation_p.P190H|SNX31_uc011lhb.1_Missense_Mutation_p.P296H	NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	sorting nexin 31	395					cell communication|protein transport		phosphatidylinositol binding				0	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TGCTTTGTTCCGGAACTTCAAT	0.347000													6	173					0	0	6.4e-05	0	0
DPYS	1807	broad.mit.edu	37	8	105456640	105456640	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr8:105456640C>T	uc003yly.3	-	4	758	c.629G>A	c.(628-630)GGG>GAG	p.G210E		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	210					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GCCTGTTATCCCCAGAGCCAA	0.498000													12	33					0	0	0.000219431	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119938803	119938803	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr8:119938803C>T	uc003yon.3	-	4	1070	c.747G>A	c.(745-747)CAG>CAA	p.Q249Q	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	249	Death 1.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			GCTGGAAAGTCTGTTCTTGTG	0.398000													86	73					0	0	0.000147903	0	0
WISP1	8840	broad.mit.edu	37	8	134239694	134239694	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr8:134239694C>T	uc003yub.2	+	5	921	c.845C>T	c.(844-846)TCC>TTC	p.S282F	WISP1_uc003yuc.2_Missense_Mutation_p.S195F|WISP1_uc010meb.2_Missense_Mutation_p.S110F|WISP1_uc010mec.2_Silent_p.I130I|WISP1_uc010med.2_Missense_Mutation_p.S37F|WISP1_uc003yud.2_RNA	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	282	CTCK.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CCAGAGGCATCCATGAACTTC	0.517000													20	42					0	0	0.000229342	0	0
ZFP41	286128	broad.mit.edu	37	8	144332304	144332304	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr8:144332304G>A	uc003yxw.2	+	2	649	c.291G>A	c.(289-291)AAG>AAA	p.K97K	ZFP41_uc003yxv.2_RNA	NM_173832	NP_776193	Q8N8Y5	ZFP41_HUMAN	zinc finger protein 41 homolog	97	C2H2-type 1.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GGATCTTTAAGCACAAGACAG	0.527000													29	22					0	0	0.000147802	0	0
PTPRD	5789	broad.mit.edu	37	9	8317942	8317942	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr9:8317942C>T	uc003zkk.2	-	45	6382	c.5671G>A	c.(5671-5673)GAT>AAT	p.D1891N	PTPRD_uc003zkp.2_Missense_Mutation_p.D1485N|PTPRD_uc003zkq.2_Missense_Mutation_p.D1484N|PTPRD_uc003zkr.2_Missense_Mutation_p.D1475N|PTPRD_uc003zks.2_Missense_Mutation_p.D1484N|PTPRD_uc003zkl.2_Missense_Mutation_p.D1882N|PTPRD_uc003zkm.2_Missense_Mutation_p.D1878N|PTPRD_uc003zkn.2_Missense_Mutation_p.D1480N|PTPRD_uc003zko.2_Missense_Mutation_p.D1481N	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1891	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGATATTGATCCTGCAGGAGA	0.383000										TSP Lung(15;0.13)			9	9					0	0	0.000673444	0	0
DDX58	23586	broad.mit.edu	37	9	32500834	32500834	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr9:32500834G>A	uc003zra.2	-	2	368	c.210C>T	c.(208-210)TTC>TTT	p.F70F	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Intron|DDX58_uc011lnr.1_5'UTR|DDX58_uc010mji.2_5'UTR	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	70	CARD 1.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		AAAAGCCACGGAACCAGCCTT	0.443000													30	20					0	0	0.000227799	0	0
STOML2	30968	broad.mit.edu	37	9	35100138	35100138	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr9:35100138G>A	uc003zwi.2	-	10	1028	c.965C>T	c.(964-966)GCC>GTC	p.A322V	STOML2_uc003zwh.2_Missense_Mutation_p.A213V|STOML2_uc003zwj.2_Missense_Mutation_p.A213V|STOML2_uc011lou.1_Missense_Mutation_p.A277V|STOML2_uc003zwk.2_Missense_Mutation_p.A271V	NM_013442	NP_038470	Q9UJZ1	STML2_HUMAN	stomatin (EPB72)-like 2	322						cytoskeleton	receptor binding				0			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGGCACTGGGGCTTTGGTGAG	0.542000													30	22					0	0	0.000491102	0	0
Unknown	0	broad.mit.edu	37	9	43828117	43828117	+	RNA	SNP	T	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr9:43828117T>C	uc004acz.1	+	9		c.1605T>C								Homo sapiens cDNA FLJ30083 fis, clone BGGI12001097, weakly similar to Homo sapiens contactin associated protein (Caspr) mRNA.																		TCTGTATCCTTCTCTGCCAAG	0.453000													28	20					0	0	0.000339439	0	0
PGM5	5239	broad.mit.edu	37	9	70999394	70999394	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr9:70999394C>T	uc004agr.2	+	3	734	c.505C>T	c.(505-507)CGA>TGA	p.R169*		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	169					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						TCCTGATCTCCGAATCGACCT	0.378000													20	14					0	0	0.000132079	0	0
RORB	6096	broad.mit.edu	37	9	77300508	77300508	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr9:77300508C>T	uc004aji.2	+	10	1436	c.1387C>T	c.(1387-1389)CCT>TCT	p.P463S	RORB_uc004ajh.2_Missense_Mutation_p.P452S	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	463	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GCTCTTTAATCCTGACTGTGC	0.438000													22	16					0	0	0.000117367	0	0
OR1N1	138883	broad.mit.edu	37	9	125289385	125289385	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr9:125289385T>C	uc004bmn.1	-	1	188	c.188A>G	c.(187-189)AAC>AGC	p.N63S		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						AAAAGACAGGTTGGCCAAGAA	0.498000													15	12					0	0	0.000566183	0	0
QSOX2	169714	broad.mit.edu	37	9	139113687	139113687	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr9:139113687G>A	uc010nbi.2	-	6	814	c.776C>T	c.(775-777)TCG>TTG	p.S259L		NM_181701	NP_859052	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2 precursor	259					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		CAGGTAACACGAAGGGACTGA	0.537000													17	9					0	0	7.07596e-05	0	0
ARSH	347527	broad.mit.edu	37	X	2933279	2933279	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:2933279C>T	uc011mhj.1	+	4	609	c.609C>T	c.(607-609)CTC>CTT	p.L203L		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	203	Helical; (Potential).					integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TTGCTCTCCTCGCCTTTCTGT	0.478000													8	1					0	0	0.000157383	0	0
MAGEB16	139604	broad.mit.edu	37	X	35821039	35821039	+	Silent	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:35821039C>T	uc010ngt.1	+	2	1005	c.726C>T	c.(724-726)ATC>ATT	p.I242I		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	242	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						AGCACTTCATCTTTGGAGAGC	0.488000													5	5					0	0	3.59834e-05	0	0
ZNF182	7569	broad.mit.edu	37	X	47837101	47837101	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:47837101T>C	uc004dir.2	-	7	731	c.385A>G	c.(385-387)ATT>GTT	p.I129V	ZNF182_uc004dis.2_Missense_Mutation_p.I110V|ZNF182_uc004dit.2_Missense_Mutation_p.I129V|ZNF182_uc011mlu.1_Missense_Mutation_p.I109V	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						TTGGTGATAATTGTTTTCTTG	0.393000													20	9					0	0	0.000132079	0	0
IQSEC2	23096	broad.mit.edu	37	X	53268417	53268417	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:53268417G>A	uc004dsd.2	-	11	3276	c.3075C>T	c.(3073-3075)TTC>TTT	p.F1025F	IQSEC2_uc004dsc.2_Silent_p.F820F	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	1015	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						CCACGAGGGGGAAAGACTGAC	0.512000											OREG0019800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	5					0	0	0.00047179	0	0
AWAT2	158835	broad.mit.edu	37	X	69261693	69261693	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:69261693C>T	uc004dxt.1	-	7	973	c.967G>A	c.(967-969)GGT>AGT	p.G323S		NM_001002254	NP_001002254	Q6E213	AWAT2_HUMAN	wax synthase 2	323						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity				0						TCTGAGATACCAAACTTGGTC	0.483000													15	2					0	0	7.07596e-05	0	0
XIST	7503	broad.mit.edu	37	X	73063782	73063782	+	RNA	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:73063782C>T	uc004ebm.1	-	1		c.8807G>A				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0						TGTTGATAGTCCACCAGAAGG	0.403000													11	3					0	0	0.000673444	0	0
KLHL4	56062	broad.mit.edu	37	X	86880675	86880675	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:86880675G>A	uc004efb.2	+	6	1385	c.1203G>A	c.(1201-1203)ATG>ATA	p.M401I	KLHL4_uc004efa.2_Missense_Mutation_p.M401I	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	401						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding	p.M401I(1)		ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AGCTCCTGATGGAAGCTATGA	0.433000													15	4					0	0	0.000422831	0	0
COL4A6	1288	broad.mit.edu	37	X	107417781	107417781	+	Silent	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:107417781G>A	uc004enw.3	-	31	3133	c.3030C>T	c.(3028-3030)ATC>ATT	p.I1010I	COL4A6_uc004env.3_Silent_p.I1009I|COL4A6_uc011msn.1_Silent_p.I1009I|COL4A6_uc010npk.2_Silent_p.I1009I	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1010	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						TAACTCCTTTGATAATGCCTG	0.547000									Alport_syndrome_with_Diffuse_Leiomyomatosis				8	10					0	0	0.000442599	0	0
ODZ1	10178	broad.mit.edu	37	X	123587288	123587288	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:123587288G>A	uc004euj.2	-	22	4046	c.3982C>T	c.(3982-3984)CGC>TGC	p.R1328C	ODZ1_uc011muj.1_Missense_Mutation_p.R1334C|ODZ1_uc010nqy.2_Missense_Mutation_p.R1335C	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1328	NHL 2.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCAATTTTGCGAATCATAGTC	0.423000													31	8					0	0	0.000339439	0	0
OR13H1	347468	broad.mit.edu	37	X	130678510	130678510	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:130678510C>T	uc011muw.1	+	1	463	c.463C>T	c.(463-465)CTC>TTC	p.L155F	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					ATCACTTGTGCTCACTGCCAT	0.502000													28	9					0	0	0.000339439	0	0
CDR1	1038	broad.mit.edu	37	X	139865886	139865886	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chrX:139865886C>T	uc004fbg.1	-	1	838	c.646G>A	c.(646-648)GGA>AGA	p.G216R	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	216											0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCAGGTCTTCCAGTCAATCCA	0.438000													21	11					0	0	0.000375601	0	0
COL20A1	57642	broad.mit.edu	37	20	61943784	61943784	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr20:61943784delG	uc011aau.1	+	15	1916	c.1816delG	c.(1816-1818)GGGfs	p.G606fs	COL20A1_uc011aav.1_Frame_Shift_Del_p.G427fs	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	606	Fibronectin type-III 4.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					AGAGGCTCCTGGGAACGCCAC	0.672													2	4	---	---	---	---					
RBM9	23543	broad.mit.edu	37	22	36152169	36152169	+	Frame_Shift_Del	DEL	A	-	-			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr22:36152169delA	uc003aon.3	-	11	1244	c.1132delT	c.(1132-1134)TACfs	p.Y378fs	RBM9_uc003aog.3_Frame_Shift_Del_p.Y284fs|RBM9_uc003aol.3_Frame_Shift_Del_p.Y303fs|RBM9_uc003aoj.3_Frame_Shift_Del_p.Y307fs|RBM9_uc003aok.3_Intron|RBM9_uc003aoh.3_Intron|RBM9_uc003aom.3_Frame_Shift_Del_p.Y285fs|RBM9_uc010gwu.2_Frame_Shift_Del_p.Y283fs|RBM9_uc003aoo.3_Frame_Shift_Del_p.Y377fs	NM_001082578	NP_001076047	O43251	RFOX2_HUMAN	RNA binding motif protein 9 isoform 5	317	Ala-rich.				estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding				0						TCAGCACCGTAAAATCCGTCC	0.353													2	4	---	---	---	---					
EFHC1	114327	broad.mit.edu	37	6	52319006	52319006	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:52319006delC	uc003pap.3	+	5	1052	c.837delC	c.(835-837)CACfs	p.H279fs	EFHC1_uc011dwv.1_Frame_Shift_Del_p.H188fs|EFHC1_uc011dww.1_Frame_Shift_Del_p.H260fs	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	279	DM10 2.					axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					GAGAGGTCCACGAACGGAATG	0.433													27	30	---	---	---	---					
SIM1	6492	broad.mit.edu	37	6	100838735	100838735	+	Frame_Shift_Del	DEL	T	-	-			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr6:100838735delT	uc003pqj.3	-	11	2010	c.1803delA	c.(1801-1803)AAAfs	p.K601fs	SIM1_uc010kcu.2_Frame_Shift_Del_p.K601fs	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	601	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		ACAGGGAGTGTTTTTTCCCAG	0.483													7	27	---	---	---	---					
C7orf47	221908	broad.mit.edu	37	7	100033871	100033871	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D3-A2JP-06A-11D-A19A-08	TCGA-D3-A2JP-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	e7a31a49-d8ae-4f47-ae7f-d9aebfb482a1	4c97cfe7-dd20-41c9-be79-1f017cf0909d	g.chr7:100033871delC	uc003uuy.1	-	1	224	c.127delG	c.(127-129)GACfs	p.D43fs	C7orf47_uc003uux.1_5'UTR	NM_145030	NP_659467	Q8TAP8	CG047_HUMAN	hypothetical protein LOC221908	43	Pro-rich.									ovary(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGGCTCAAGTCCAGGCCGGGC	0.602													2	4	---	---	---	---					
