Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIAA0562	9731	broad.mit.edu	37	1	3742397	3742397	+	Silent	SNP	G	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:3742397G>T	uc001aky.2	-	18	2648	c.2289C>A	c.(2287-2289)TCC>TCA	p.S763S	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	763						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		CCTCTGTGAAGGATTCACTCC	0.498													26	63					1.08312e-15	3.98849e-15	0.00178596	1	0
RERE	473	broad.mit.edu	37	1	8418512	8418512	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:8418512G>A	uc001ape.2	-	21	4893	c.4083C>T	c.(4081-4083)CCC>CCT	p.P1361P	RERE_uc001apf.2_Silent_p.P1361P|RERE_uc001apd.2_Silent_p.P807P	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1361					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CAAAAGGGTGGGGCCCGGCGG	0.697													4	13					0	0	0.00024832	0	0
H6PD	9563	broad.mit.edu	37	1	9322191	9322191	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:9322191C>T	uc001apt.2	+	4	1092	c.819C>T	c.(817-819)ACC>ACT	p.T273T		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	273	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	AGGTCCTCACCCTCGTGGCCA	0.642													16	30					0	0	0.00074312	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12835246	12835246	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:12835246G>A	uc001aui.2	+	1	263	c.236G>A	c.(235-237)CGA>CAA	p.R79Q		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	79										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAGATCTTTCGAGCTGTGCTG	0.582													30	68					0	0	0.00209593	0	0
PRDM2	7799	broad.mit.edu	37	1	14107476	14107476	+	Silent	SNP	T	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:14107476T>G	uc001avi.2	+	8	4042	c.3186T>G	c.(3184-3186)TCT>TCG	p.S1062S	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Silent_p.S1062S|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Silent_p.S861S|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1062	Poly-Ser.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		cctcctcctcttcgttttctt	0.383													9	18					0	0	0.000274275	0	0
DNAJC16	23341	broad.mit.edu	37	1	15890475	15890475	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:15890475C>T	uc001aws.2	+	10	1510	c.1390C>T	c.(1390-1392)CTG>TTG	p.L464L	DNAJC16_uc001awr.1_Silent_p.L464L|DNAJC16_uc001awt.2_Silent_p.L152L|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	464	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GTATAAAACCCTGGAAGACCC	0.443													96	143					0	0	0.000781405	0	0
C1orf94	84970	broad.mit.edu	37	1	34663240	34663240	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:34663240G>A	uc001bxs.3	+	2	564	c.165G>A	c.(163-165)CTG>CTA	p.L55L	C1orf94_uc001bxt.2_Silent_p.L245L	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	55							protein binding				0		Myeloproliferative disorder(586;0.0393)				AGTTCCCACTGAAGTCCACTG	0.562													26	34					0	0	0.00127121	0	0
MACF1	23499	broad.mit.edu	37	1	39753029	39753029	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:39753029T>C	uc010ois.1	+	16	1800	c.1595T>C	c.(1594-1596)TTC>TCC	p.F532S	MACF1_uc001cda.1_Missense_Mutation_p.F440S	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	532					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAGGGTCATTTCACTTCACTT	0.463													54	139					0	0	0.000781405	0	0
ERMAP	114625	broad.mit.edu	37	1	43296721	43296721	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:43296721C>G	uc001cic.1	+	4	638	c.368C>G	c.(367-369)TCT>TGT	p.S123C	ERMAP_uc010ojw.1_Missense_Mutation_p.S184C|ERMAP_uc001cid.1_Intron|ERMAP_uc001cie.1_Missense_Mutation_p.S123C|ERMAP_uc001cif.1_Missense_Mutation_p.S33C	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	123	Ig-like V-type.|Extracellular (Potential).		Missing (in Sc-3 allele).			integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GACCAAGGGTCTTACCGATGT	0.522													15	33					0	0	0.000422831	0	0
C1orf168	199920	broad.mit.edu	37	1	57204318	57204318	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:57204318G>A	uc001cym.3	-	14	2118	c.1712C>T	c.(1711-1713)TCC>TTC	p.S571F	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_Intron	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	571										ovary(3)|skin(2)	5						CAGCAAAATGGAAAATGCACT	0.378													31	62					0	0	0.00128727	0	0
LEPR	3953	broad.mit.edu	37	1	66058373	66058373	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:66058373C>T	uc001dci.2	+	6	730	c.528C>T	c.(526-528)CCC>CCT	p.P176P	LEPR_uc001dcg.2_Silent_p.P176P|LEPR_uc001dch.2_Silent_p.P176P|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Silent_p.P176P|LEPR_uc001dck.2_Silent_p.P176P	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	176	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CTCTGGTTCCCCAAAAAGGCA	0.353													11	28					0	0	0.000978159	0	0
COL11A1	1301	broad.mit.edu	37	1	103471820	103471820	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:103471820T>A	uc001dul.2	-	16	2053	c.1735A>T	c.(1735-1737)AGG>TGG	p.R579W	COL11A1_uc001duk.2_Translation_Start_Site|COL11A1_uc001dum.2_Missense_Mutation_p.R591W|COL11A1_uc001dun.2_Missense_Mutation_p.R540W|COL11A1_uc009weh.2_Missense_Mutation_p.R463W	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	579	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGCCATACCCTTTTTCCAGGT	0.353													54	81					0	0	0.000781405	0	0
CD53	963	broad.mit.edu	37	1	111441775	111441775	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:111441775G>A	uc001dzw.2	+	9	789	c.618G>A	c.(616-618)CTG>CTA	p.L206L	CD53_uc001dzx.2_Silent_p.L206L|CD53_uc010owa.1_Silent_p.L147L|CD53_uc001dzy.2_Silent_p.L151L	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	206	Helical; (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		CACTGACCCTGAACTGCCAGA	0.443													19	52					0	0	0.00047179	0	0
CHIA	27159	broad.mit.edu	37	1	111862065	111862065	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:111862065G>A	uc001eas.2	+	11	1255	c.1152G>A	c.(1150-1152)AAG>AAA	p.K384K	CHIA_uc001ear.2_Silent_p.K276K|CHIA_uc001eaq.2_Silent_p.K276K|CHIA_uc009wgc.2_Silent_p.K276K|CHIA_uc001eat.2_Silent_p.K223K|CHIA_uc001eav.2_Silent_p.K223K|CHIA_uc001eau.2_Silent_p.K223K|CHIA_uc009wgd.2_Silent_p.K223K	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	384					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		CCACCCTGAAGAAGGCCCTCG	0.517													16	45					0	0	0.000958276	0	0
SYCP1	6847	broad.mit.edu	37	1	115454127	115454127	+	Silent	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:115454127T>C	uc001efr.2	+	18	1662	c.1453T>C	c.(1453-1455)TTA>CTA	p.L485L	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Silent_p.L485L|SYCP1_uc009wgw.2_Silent_p.L485L	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	485	Potential.			IQLTAITTSEQYYSKEVKDLKTELENEK -> YSYCHYHKW TVLPKRGQRPKLSSKRE (in Ref. 2; BAA22586).	cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGAAATACAGTTAACTGCCAT	0.294													10	35					0	0	0.00136819	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144679930	144679930	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:144679930C>T	uc001elo.2	-	5	809	c.592G>A	c.(592-594)GAA>AAA	p.E198K	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc009wig.1_Intron|NBPF9_uc001eli.3_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF9_uc009wii.1_Intron|PDE4DIP_uc001elk.1_Missense_Mutation_p.E61K|PDE4DIP_uc001ell.1_Missense_Mutation_p.E64K|PDE4DIP_uc001elm.3_Missense_Mutation_p.E29K|PDE4DIP_uc001eln.3_Missense_Mutation_p.E127K	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	61	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCTGGAGTTCTCGTTTCAAG	0.418			T	PDGFRB	MPD								6	55					0	0	0.000274275	0	0
ANKRD35	148741	broad.mit.edu	37	1	145561156	145561157	+	Missense_Mutation	DNP	GA	AT	AT			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:145561156_145561157GA>AT	uc001eob.1	+	10	952_953	c.844_845GA>AT	c.(844-846)GAA>ATA	p.E282I	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.E125I	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	282										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AGCAGAGCCTGAAGAGGAGCAA	0.55													13	35					0	0	6.4e-05	0	0
LOC200030	200030	broad.mit.edu	37	1	148342006	148342007	+	Splice_Site	DNP	CC	AA	AA			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:148342006_148342007CC>AA	uc001eqf.2	-	5	602	c.567_splice	c.e5-1	p.R189_splice	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqg.2_Intron|NBPF14_uc009wkf.1_Splice_Site|uc001erd.3_Splice_Site_p.R189_splice|uc001erc.3_Splice_Site|uc010paj.1_Intron|uc010pau.1_5'UTR|uc010pav.1_Splice_Site_p.R189_splice|uc010paw.1_Splice_Site_p.R114_splice	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672							cytoplasm					0						TCTGCACCTCCCTGATGAGCCA	0.525													10	607					0	0	6.4e-05	0	0
CRNN	49860	broad.mit.edu	37	1	152383020	152383020	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:152383020T>C	uc001ezx.2	-	3	612	c.538A>G	c.(538-540)AGC>GGC	p.S180G		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	180	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCTGCGGGCTTATTCTTTCC	0.572													101	167					0	0	0.000781405	0	0
DCST1	149095	broad.mit.edu	37	1	155013970	155013970	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:155013970A>G	uc001fgn.1	+	7	725	c.629A>G	c.(628-630)GAG>GGG	p.E210G	DCST1_uc010per.1_Missense_Mutation_p.E235G|DCST1_uc010pes.1_Missense_Mutation_p.E185G	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	210	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TACACGCCTGAGGATACCATG	0.577													18	50					0	0	0.00074312	0	0
GON4L	54856	broad.mit.edu	37	1	155823261	155823261	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:155823261G>A	uc001flz.2	-	2	408	c.311C>T	c.(310-312)ACC>ATC	p.T104I	GON4L_uc001fly.1_Missense_Mutation_p.T104I|GON4L_uc009wrh.1_Missense_Mutation_p.T104I|GON4L_uc001fma.1_Missense_Mutation_p.T104I|GON4L_uc001fmc.2_Missense_Mutation_p.T104I|GON4L_uc001fmd.3_Missense_Mutation_p.T104I|GON4L_uc009wri.2_5'UTR	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	104					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGAAGGTAGGGTGATTCCCTG	0.453													51	87					0	0	0.000781405	0	0
FCRL1	115350	broad.mit.edu	37	1	157771776	157771776	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:157771776C>T	uc001frg.2	-	5	928	c.815G>A	c.(814-816)GGA>GAA	p.G272E	FCRL1_uc001frf.2_RNA|FCRL1_uc001frh.2_Missense_Mutation_p.G272E|FCRL1_uc001fri.2_Missense_Mutation_p.G272E|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	272	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GGAGTAGTTTCCAGAATGTTC	0.557													25	62					0	0	0.000586117	0	0
OR10K1	391109	broad.mit.edu	37	1	158436017	158436017	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:158436017C>T	uc010pij.1	+	1	666	c.666C>T	c.(664-666)ATC>ATT	p.I222I		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCCGCATCATCTCTGCCATTC	0.478													27	58					0	0	0.000586117	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576309	158576309	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:158576309C>T	uc010pio.1	+	1	81	c.81C>T	c.(79-81)CTC>CTT	p.L27L		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					AGCTCCTTCTCTTTGCCTTGT	0.507													31	73					0	0	0.00127121	0	0
ATP1A4	480	broad.mit.edu	37	1	160141540	160141540	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:160141540G>A	uc001fve.3	+	12	2326	c.1847G>A	c.(1846-1848)GGA>GAA	p.G616E	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.G119E	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	616	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CGCAGTGCAGGAATTAAGGTA	0.498													33	85					0	0	0.000692331	0	0
ADCY10	55811	broad.mit.edu	37	1	167805774	167805774	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:167805774C>T	uc001ger.2	-	23	3380	c.3082G>A	c.(3082-3084)GAA>AAA	p.E1028K	ADCY10_uc009wvj.2_5'Flank|ADCY10_uc009wvk.2_Missense_Mutation_p.E936K|ADCY10_uc010plj.1_Missense_Mutation_p.E875K	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1028					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						CTTATTTCTTCAGGACTGTCC	0.264													20	65					0	0	0.00229938	0	0
BAT2L2	23215	broad.mit.edu	37	1	171509511	171509511	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:171509511C>T	uc010pmg.1	+	16	3166	c.2900C>T	c.(2899-2901)CCA>CTA	p.P967L	BAT2L2_uc010pmh.1_5'UTR	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	967							protein C-terminus binding				0						GAGGAGAAACCAAAAAAGGAA	0.418													5	21					0	0	0.00116845	0	0
KLHL20	27252	broad.mit.edu	37	1	173725152	173725152	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:173725152C>T	uc001gjc.2	+	6	1121	c.942C>T	c.(940-942)ATC>ATT	p.I314I	KLHL20_uc010pmr.1_Silent_p.I125I|KLHL20_uc009wwf.2_Silent_p.I296I	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	314					cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						GGAAACCTATCCGATGTGGGG	0.418													15	40					0	0	0.000308642	0	0
TNN	63923	broad.mit.edu	37	1	175046806	175046806	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:175046806C>T	uc001gkl.1	+	2	365	c.252C>T	c.(250-252)ATC>ATT	p.I84I	TNN_uc010pmx.1_Silent_p.I84I	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	84					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AACAGAACATCATCTTCAGGC	0.612													11	24					0	0	0.00136819	0	0
DHX9	1660	broad.mit.edu	37	1	182845266	182845266	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:182845266C>T	uc001gpr.2	+	17	2060	c.1897C>T	c.(1897-1899)CCT>TCT	p.P633S	DHX9_uc001gps.2_Missense_Mutation_p.P419S	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	633					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						AAAGGAAACTCCTTTTGAACT	0.398													34	68					0	0	0.0024448	0	0
CFHR5	81494	broad.mit.edu	37	1	196964856	196964856	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:196964856G>A	uc001gts.3	+	5	745	c.617G>A	c.(616-618)CGA>CAA	p.R206Q		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	206	Sushi 4.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						GGACAAGTACGATCATGTGGT	0.323													35	71					0	0	0.00128727	0	0
PKP1	5317	broad.mit.edu	37	1	201294148	201294148	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:201294148C>T	uc001gwd.2	+	12	2228	c.1977C>T	c.(1975-1977)TCC>TCT	p.S659S	PKP1_uc001gwe.2_Silent_p.S638S|PKP1_uc009wzm.2_Silent_p.S246S	NM_000299	NP_000290	Q13835	PKP1_HUMAN	plakophilin 1 isoform 1b	659	ARM 9.				cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			ovary(2)	2						ACATCTTGTCCTCGGCCTGCT	0.577													71	126					0	0	0.000781405	0	0
NFASC	23114	broad.mit.edu	37	1	204946814	204946814	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:204946814C>T	uc001hbj.2	+	17	2165	c.1837C>T	c.(1837-1839)CAG>TAG	p.Q613*	NFASC_uc010pra.1_Intron|NFASC_uc001hbi.2_Intron|NFASC_uc010prb.1_Nonsense_Mutation_p.Q624*|NFASC_uc010prc.1_Nonsense_Mutation_p.Q180*|NFASC_uc001hbk.1_Intron	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	613	Extracellular (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGCAGCTGATCAGGCCACTCC	0.537													10	24					0	0	0.000978159	0	0
C1orf186	440712	broad.mit.edu	37	1	206239499	206239499	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:206239499C>T	uc001hdt.1	-	6	1038	c.399G>A	c.(397-399)GAG>GAA	p.E133E		NM_001007544	NP_001007545	Q6ZWK4	CA186_HUMAN	hypothetical protein LOC440712	133						integral to membrane					0			BRCA - Breast invasive adenocarcinoma(75;0.0754)			CCTTTATGTTCTCATAGTCCA	0.448													10	33					0	0	0.000673444	0	0
CR2	1380	broad.mit.edu	37	1	207643212	207643212	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:207643212G>A	uc001hfw.2	+	6	1084	c.990G>A	c.(988-990)CAG>CAA	p.Q330Q	CR2_uc001hfv.2_Silent_p.Q330Q|CR2_uc009xch.2_Silent_p.Q330Q|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	330	Sushi 5.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TTGATAGTCAGAAGACTGGGA	0.517													12	17					0	0	0.00136819	0	0
FAM71A	149647	broad.mit.edu	37	1	212799719	212799719	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:212799719G>A	uc001hjk.2	+	1	1904	c.1500G>A	c.(1498-1500)AAG>AAA	p.K500K	uc010pth.1_RNA	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	500										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CCATCTCAAAGGAGTCCAGGA	0.557													37	66					0	0	0.00222228	0	0
RYR2	6262	broad.mit.edu	37	1	237838033	237838033	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:237838033G>A	uc001hyl.1	+	60	8837	c.8717G>A	c.(8716-8718)GGA>GAA	p.G2906E	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2906	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.|4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTTCCAGAGGATTTAAGGAC	0.353													13	20					0	0	0.000308642	0	0
GREM2	64388	broad.mit.edu	37	1	240656512	240656512	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:240656512C>T	uc001hys.2	-	2	544	c.264G>A	c.(262-264)CGG>CGA	p.R88R		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	88	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			TGGTGCGGCTCCGGCAGCCCT	0.647													13	39					0	0	0.000308642	0	0
KIF26B	55083	broad.mit.edu	37	1	245849121	245849122	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:245849121_245849122CC>TT	uc001ibf.1	+	12	3276_3277	c.2836_2837CC>TT	c.(2836-2838)CCT>TTT	p.P946F	KIF26B_uc001ibg.1_Missense_Mutation_p.P564F|KIF26B_uc001ibh.1_Missense_Mutation_p.P188F	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	946					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CAGCAGCTTTCCTTTCGAAGAA	0.604													9	20					0	0	6.4e-05	0	0
OR2T2	401992	broad.mit.edu	37	1	248616137	248616137	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr1:248616137C>T	uc001iek.1	+	1	39	c.39C>T	c.(37-39)TTC>TTT	p.F13F		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCACTAACTTCGTCCTCACAG	0.507													30	140					0	0	0.000781405	0	0
SYT15	83849	broad.mit.edu	37	10	46968679	46968679	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr10:46968679C>T	uc001jea.2	-	3	410	c.257G>A	c.(256-258)CGA>CAA	p.R86Q	SYT15_uc001jdz.2_Missense_Mutation_p.R86Q|SYT15_uc001jeb.2_5'UTR|SYT15_uc010qfp.1_5'Flank	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	86	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						CACCCAATCTCGGCCTTGAAG	0.632													13	42					0	0	0.00244969	0	0
PCDH15	65217	broad.mit.edu	37	10	55570336	55570336	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr10:55570336C>T	uc010qhs.1	-	36	4893	c.4498G>A	c.(4498-4500)GAA>AAA	p.E1500K	PCDH15_uc010qhq.1_Missense_Mutation_p.E1493K|PCDH15_uc010qhr.1_Missense_Mutation_p.E1488K|PCDH15_uc010qht.1_Missense_Mutation_p.E1493K|PCDH15_uc010qhu.1_Silent_p.R1511R	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCATATTCTTCCTCAGCTTCA	0.393										HNSCC(58;0.16)			53	56					0	0	0.000781405	0	0
PCDH15	65217	broad.mit.edu	37	10	55826552	55826552	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr10:55826552C>T	uc001jju.1	-	18	2580	c.2185G>A	c.(2185-2187)GAA>AAA	p.E729K	PCDH15_uc010qhq.1_Missense_Mutation_p.E734K|PCDH15_uc010qhr.1_Missense_Mutation_p.E729K|PCDH15_uc010qhs.1_Missense_Mutation_p.E741K|PCDH15_uc010qht.1_Missense_Mutation_p.E736K|PCDH15_uc010qhu.1_Missense_Mutation_p.E729K|PCDH15_uc001jjv.1_Missense_Mutation_p.E707K|PCDH15_uc010qhv.1_Missense_Mutation_p.E729K|PCDH15_uc010qhw.1_Missense_Mutation_p.E692K|PCDH15_uc010qhx.1_Missense_Mutation_p.E658K|PCDH15_uc010qhy.1_Missense_Mutation_p.E734K|PCDH15_uc010qhz.1_Missense_Mutation_p.E729K|PCDH15_uc010qia.1_Missense_Mutation_p.E707K|PCDH15_uc010qib.1_Missense_Mutation_p.E707K|PCDH15_uc001jjw.2_Missense_Mutation_p.E729K	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	729	Extracellular (Potential).|Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GCTTCTTCTTCCACCACAGAT	0.348										HNSCC(58;0.16)			26	22					0	0	0.000586117	0	0
CDHR1	92211	broad.mit.edu	37	10	85972965	85972965	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr10:85972965C>T	uc001kcv.2	+	16	1901	c.1901C>T	c.(1900-1902)TCC>TTC	p.S634F	CDHR1_uc001kcw.2_Missense_Mutation_p.S634F|CDHR1_uc009xst.2_Missense_Mutation_p.S338F|CDHR1_uc001kcx.2_5'UTR	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	634	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						CTCAAGAATTCCATCCGCTCC	0.587													32	42					0	0	0.00058488	0	0
MUC5B	727897	broad.mit.edu	37	11	1271262	1271262	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:1271262C>T	uc009ycr.1	+	51	14697	c.14571C>T	c.(14569-14571)TCC>TCT	p.S4857S	MUC5B_uc001ltb.2_Silent_p.S4387S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4384	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCCCTCCTCCACTCCGGGGA	0.667													39	26					0	0	0.00195071	0	0
OR10A6	390093	broad.mit.edu	37	11	7949581	7949581	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:7949581G>A	uc010rbh.1	-	1	629	c.629C>T	c.(628-630)CCT>CTT	p.P210L		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAACAAGAAAGGAACCAAAAT	0.423													12	13					0	0	0.000978159	0	0
LOC494141	494141	broad.mit.edu	37	11	18231859	18231859	+	RNA	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:18231859G>A	uc009yhh.2	+	2		c.883G>A			LOC494141_uc001mnx.3_RNA|LOC494141_uc009yhi.1_RNA	NR_026541				Homo sapiens cDNA FLJ29025 fis, clone PRS03236.												0						ATTCTCATTTGGTCAATGATT	0.423													10	11					0	0	0.000978159	0	0
GTF2H1	2965	broad.mit.edu	37	11	18357426	18357426	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:18357426G>A	uc001moi.2	+	4	974	c.280G>A	c.(280-282)GAC>AAC	p.D94N	GTF2H1_uc001moh.2_Missense_Mutation_p.D94N|GTF2H1_uc009yhm.2_Intron	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	94					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding				0						TGCAGTAAAAGACCTTCTTCA	0.428								NER					23	43					0	0	0.000586117	0	0
RAPSN	5913	broad.mit.edu	37	11	47460343	47460343	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:47460343G>A	uc001nfi.1	-	7	1320	c.1106C>T	c.(1105-1107)TCC>TTC	p.S369F	RAPSN_uc001nfj.1_Missense_Mutation_p.S310F|RAPSN_uc009yls.1_Missense_Mutation_p.S310F	NM_005055	NP_005046	Q13702	RAPSN_HUMAN	43 kD receptor-associated protein of the synapse	369	RING-type.				synaptic transmission, cholinergic	cell junction|cytoskeleton|postsynaptic membrane	acetylcholine receptor binding|zinc ion binding			ovary(1)	1						CTCGCCTATGGACTCGCCGCA	0.662													3	2					0	0	6.4e-05	0	0
OR4C3	256144	broad.mit.edu	37	11	48346900	48346900	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:48346900G>A	uc010rhv.1	+	1	408	c.408G>A	c.(406-408)GAG>GAA	p.E136E		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAGGTGTTGAGATCATTCTGC	0.483													51	175					0	0	0.000781405	0	0
FOLH1	2346	broad.mit.edu	37	11	49179583	49179583	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:49179583C>T	uc001ngy.2	-	14	1714	c.1453G>A	c.(1453-1455)GAT>AAT	p.D485N	FOLH1_uc001ngz.2_Missense_Mutation_p.D485N|FOLH1_uc009yly.2_Missense_Mutation_p.D470N|FOLH1_uc009ylz.2_Missense_Mutation_p.D470N|FOLH1_uc009yma.2_Missense_Mutation_p.D177N	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	485	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AAGCCTTCATCAGGGCTTTTC	0.343													6	56					0	0	0.000157383	0	0
OR4C46	119749	broad.mit.edu	37	11	51515428	51515428	+	Silent	SNP	C	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:51515428C>A	uc010ric.1	+	1	147	c.147C>A	c.(145-147)GCC>GCA	p.A49A		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	49	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCATCACTGCCAGCCCATCAC	0.448													13	151					6.72482e-11	2.46577e-10	0.000308642	1	0
OR4C15	81309	broad.mit.edu	37	11	55322838	55322838	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:55322838G>A	uc010rig.1	+	1	1056	c.1056G>A	c.(1054-1056)AGG>AGA	p.R352R		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGGCCATGAGGAGAATATGGA	0.333										HNSCC(20;0.049)			27	19					0	0	0.000586117	0	0
OR9G9	504191	broad.mit.edu	37	11	56468245	56468245	+	Missense_Mutation	SNP	C	T	T	rs139404745		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:56468245C>T	uc010rjn.1	+	1	382	c.382C>T	c.(382-384)CCC>TCC	p.P128S		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATCTCCAAGCCCCTGCTTTA	0.517													14	119					0	0	0.000566183	0	0
MPEG1	219972	broad.mit.edu	37	11	58978890	58978890	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:58978890G>A	uc001nnu.3	-	1	1605	c.1449C>T	c.(1447-1449)TTC>TTT	p.F483F		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	483	Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				TCTTGCTGCTGAAGAGGCCCC	0.488													38	45					0	0	0.000814825	0	0
MS4A8B	83661	broad.mit.edu	37	11	60470919	60470919	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:60470919G>A	uc001npv.2	+	3	491	c.288G>A	c.(286-288)GGG>GGA	p.G96G	MS4A8B_uc009yne.1_Silent_p.G96G	NM_031457	NP_113645	Q9BY19	M4A8B_HUMAN	membrane-spanning 4-domains, subfamily A, member	96	Extracellular (Potential).					integral to membrane	receptor activity				0						TTCTCGTAGGGGAATACCTGT	0.552													15	109					0	0	0.00074312	0	0
INCENP	3619	broad.mit.edu	37	11	61895761	61895761	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:61895761G>A	uc001nsw.1	+	2	330	c.128G>A	c.(127-129)CGC>CAC	p.R43H	INCENP_uc009ynv.2_Missense_Mutation_p.R43H|INCENP_uc009ynw.1_Missense_Mutation_p.R43H|INCENP_uc001nsx.1_Missense_Mutation_p.R43H	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	43					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						GAGGCCGAGCGCATGTTCACC	0.572													23	29					0	0	0.000720815	0	0
SLC22A9	114571	broad.mit.edu	37	11	63174115	63174115	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:63174115G>A	uc001nww.2	+	7	1488	c.1220G>A	c.(1219-1221)CGA>CAA	p.R407Q	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	407	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						ATGAACCGTCGAGCAAGCCAG	0.483													14	28					0	0	0.00244969	0	0
RTN3	10313	broad.mit.edu	37	11	63486692	63486692	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:63486692G>A	uc001nxq.2	+	3	905	c.718G>A	c.(718-720)GAA>AAA	p.E240K	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Missense_Mutation_p.E221K|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Missense_Mutation_p.E128K|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	240					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						TGATGTTATTGAAAAGGATTC	0.368													7	50					0	0	0.00198382	0	0
PITPNM1	9600	broad.mit.edu	37	11	67266146	67266146	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:67266146G>A	uc001olx.2	-	9	1594	c.1405C>T	c.(1405-1407)CCT>TCT	p.P469S	PITPNM1_uc001olw.2_5'Flank|PITPNM1_uc001oly.2_Missense_Mutation_p.P469S|PITPNM1_uc001olz.2_Missense_Mutation_p.P469S	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	469					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						AAGGCCTCAGGGAAGTGGATG	0.662													4	57					0	0	0.00024832	0	0
KRTAP5-7	440050	broad.mit.edu	37	11	71238569	71238569	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:71238569G>T	uc001oqq.1	+	1	257	c.223G>T	c.(223-225)GGG>TGG	p.G75W		NM_001012503	NP_001012521	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	75	7 X 4 AA repeats of C-C-X-P.					keratin filament					0						GGGCTCCAAGGGGGGCTGTGG	0.488													60	90					7.92265e-33	2.9427e-32	0.000781405	1	0
FOLH1B	219595	broad.mit.edu	37	11	89420549	89420549	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:89420549C>T	uc001pda.2	+	9	1077	c.551C>T	c.(550-552)TCT>TTT	p.S184F		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	184					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GAAGGCAAATCTCTTTATGAA	0.348													25	32					0	0	0.00127121	0	0
ENDOD1	23052	broad.mit.edu	37	11	94862476	94862476	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:94862476C>T	uc001pfh.2	+	2	1311	c.1236C>T	c.(1234-1236)CTC>CTT	p.L412L		NM_015036	NP_055851	O94919	ENDD1_HUMAN	endonuclease domain containing 1 precursor	412						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding				0		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				TCAGGGCTCTCCTCCGGATCC	0.552													45	39					0	0	0.000781405	0	0
DDI1	414301	broad.mit.edu	37	11	103907691	103907691	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:103907691C>T	uc001phr.2	+	1	384	c.141C>T	c.(139-141)ATC>ATT	p.I47I	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	47	Ubiquitin-like.				proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		AGATCCAGATCATCCACATGG	0.557													52	42					0	0	0.000781405	0	0
GRIA4	2893	broad.mit.edu	37	11	105842717	105842717	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:105842717G>A	uc001pix.2	+	15	2817	c.2371G>A	c.(2371-2373)GAT>AAT	p.D791N	GRIA4_uc001piw.2_Intron|GRIA4_uc010rvm.1_RNA|GRIA4_uc009yxl.1_Intron	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	791	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATGGTGGTACGATAAAGGTGA	0.463													16	11					0	0	0.00074312	0	0
BCO2	83875	broad.mit.edu	37	11	112088573	112088573	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:112088573C>T	uc001pnf.2	+	12	1833	c.1716C>T	c.(1714-1716)TTC>TTT	p.F572F	BCO2_uc001png.2_Silent_p.F499F|BCO2_uc001pnh.2_Silent_p.F538F|BCO2_uc010rwt.1_Silent_p.F467F|BCO2_uc009yyn.2_Silent_p.F532F|BCO2_uc001pni.2_Silent_p.F538F	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	572					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CTTATGGGTTCCATGGTACCT	0.353													15	20					0	0	0.000422831	0	0
USP28	57646	broad.mit.edu	37	11	113677220	113677220	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:113677220C>T	uc001poh.2	-	19	2424	c.2391G>A	c.(2389-2391)GGG>GGA	p.G797G	USP28_uc001pog.2_Intron|USP28_uc010rwy.1_Intron|USP28_uc001poi.2_Intron	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	797					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		CCTTAATCAGCCCTGCTTCAG	0.438													25	25					0	0	0.00106085	0	0
VWA5A	4013	broad.mit.edu	37	11	124016027	124016027	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr11:124016027G>A	uc001pzu.2	+	18	2447	c.2238G>A	c.(2236-2238)GAG>GAA	p.E746E	VWA5A_uc001pzt.2_Silent_p.E746E	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	746										upper_aerodigestive_tract(1)|ovary(1)	2						GTGAATGGGAGCTTCTGGAAA	0.582													24	29					0	0	0.00047179	0	0
AKAP3	10566	broad.mit.edu	37	12	4747274	4747274	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:4747274C>T	uc001qnb.3	-	3	318	c.89G>A	c.(88-90)TGG>TAG	p.W30*		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	30					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						TACCATTTTCCAGTCCTGGGC	0.443													93	200					0	0	0.000781405	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6425066	6425066	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:6425066G>A	uc001qnr.2	+	6	735	c.587G>A	c.(586-588)CGA>CAA	p.R196Q	PLEKHG6_uc001qns.2_Missense_Mutation_p.R196Q|PLEKHG6_uc010sew.1_Missense_Mutation_p.R196Q|PLEKHG6_uc010sex.1_Missense_Mutation_p.R164Q	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	196	DH.				regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						AACCTGCAGCGAGTGGGACTG	0.677													5	4					0	0	0.00116845	0	0
A2M	2	broad.mit.edu	37	12	9252104	9252104	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:9252104G>A	uc001qvk.1	-	14	1687	c.1574C>T	c.(1573-1575)TCC>TTC	p.S525F	A2M_uc009zgk.1_Missense_Mutation_p.S375F	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	525					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GATTGAGATGGAAAAATGGCC	0.433													6	9					0	0	0.000157383	0	0
PZP	5858	broad.mit.edu	37	12	9309907	9309907	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:9309907C>T	uc001qvl.2	-	28	3443	c.3414G>A	c.(3412-3414)TGG>TGA	p.W1138*	PZP_uc009zgl.2_Nonsense_Mutation_p.W924*	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TTGCTACATTCCAGGCTGACT	0.488													25	52					0	0	0.000878237	0	0
KLRC3	3823	broad.mit.edu	37	12	10569334	10569334	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:10569334C>T	uc001qyf.2	-	5	564	c.519G>A	c.(517-519)TGG>TGA	p.W173*	KLRC3_uc001qyh.2_Nonsense_Mutation_p.W173*|KLRC3_uc001qyi.1_Nonsense_Mutation_p.W173*	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	173	C-type lectin.|Extracellular (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						ACACACCAATCCATGAGGAAG	0.289													12	30					0	0	0.000422831	0	0
KLRC3	3823	broad.mit.edu	37	12	10571034	10571034	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:10571034C>T	uc001qyf.2	-	4	440	c.395G>A	c.(394-396)GGT>GAT	p.G132D	KLRC3_uc001qyh.2_Missense_Mutation_p.G132D|KLRC3_uc001qyi.1_Missense_Mutation_p.G132D|KLRC3_uc010shc.1_Missense_Mutation_p.V116I|KLRC3_uc010shd.1_3'UTR	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	132	C-type lectin.|Extracellular (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						TCTTTCCTTACCAATGTAATA	0.368													36	90					0	0	0.000781405	0	0
PLCZ1	89869	broad.mit.edu	37	12	18847928	18847928	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:18847928C>T	uc010sid.1	-	12	1568	c.1377G>A	c.(1375-1377)TTG>TTA	p.L459L	PLCZ1_uc001rdv.3_Silent_p.L355L|PLCZ1_uc001rdw.3_Silent_p.L200L|PLCZ1_uc001rdu.1_Silent_p.L241L|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	459	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AATGTGGTTTCAAAATATATC	0.343													20	38					0	0	0.000958276	0	0
LYRM5	144363	broad.mit.edu	37	12	25357093	25357093	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:25357093C>T	uc001rgo.2	+	3	283	c.114C>T	c.(112-114)TTC>TTT	p.F38F	LYRM5_uc001rgn.2_Silent_p.F40F	NM_001001660	NP_001001660	Q6IPR1	LYRM5_HUMAN	LYR motif containing 5	38											0	all_cancers(2;4.75e-35)|all_epithelial(2;1.91e-37)|all_lung(3;1.07e-23)|Lung NSC(3;5.49e-23)|Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.0016)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;2.21e-21)|Epithelial(3;8.04e-19)|all cancers(3;2.26e-16)|STAD - Stomach adenocarcinoma(2;0.00138)			AGAACATTTTCCTTAAAAACA	0.338													24	37					0	0	0.00229938	0	0
IPO8	10526	broad.mit.edu	37	12	30818721	30818721	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:30818721G>A	uc001rjd.2	-	12	1450	c.1280C>T	c.(1279-1281)CCT>CTT	p.P427L	IPO8_uc001rje.1_5'Flank|IPO8_uc010sjt.1_Missense_Mutation_p.P222L	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	427					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TTTCTTCCTAGGGTCAAAGTT	0.353													20	42					0	0	0.00229938	0	0
GXYLT1	283464	broad.mit.edu	37	12	42499824	42499824	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:42499824G>A	uc001rms.3	-	5	885	c.660C>T	c.(658-660)ATC>ATT	p.I220I	GXYLT1_uc001rmt.3_Silent_p.I189I	NM_173601	NP_775872	Q4G148	GXLT1_HUMAN	glycosyltransferase 8 domain containing 3	220	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						GTAAAAAAAGGATATCAGTGT	0.323													21	55					0	0	0.00229938	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43887025	43887025	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:43887025C>T	uc010skx.1	-	5	899	c.899G>A	c.(898-900)GGA>GAA	p.G300E		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	300	Peptidase M12B.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TATCAAATTTCCAATACTTGG	0.289													3	11					0	0	6.4e-05	0	0
MFSD5	84975	broad.mit.edu	37	12	53646733	53646733	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:53646733C>T	uc001sci.1	+	2	305	c.114C>T	c.(112-114)TTC>TTT	p.F38F	MFSD5_uc001sch.1_Silent_p.F145F	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	38					transport	integral to membrane				skin(2)|ovary(1)	3						ATCCCTCCTTCCTTCGGTTTC	0.557													66	91					0	0	0.000781405	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54911364	54911364	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:54911364C>T	uc001sgc.3	+	12	1222	c.1143C>T	c.(1141-1143)ACC>ACT	p.T381T	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Silent_p.T331T	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	381					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						ATGAGGTCACCTGGCTGGTTC	0.438													40	63					0	0	0.00285205	0	0
ZBTB39	9880	broad.mit.edu	37	12	57398619	57398619	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:57398619G>A	uc001sml.1	-	2	169	c.83C>T	c.(82-84)ACC>ATC	p.T28I	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						GTCGCACATGGTCTCTGAGAG	0.562													51	90					0	0	0.000781405	0	0
STAC3	246329	broad.mit.edu	37	12	57640632	57640632	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:57640632G>A	uc001snp.2	-	6	753	c.558C>T	c.(556-558)ATC>ATT	p.I186I	STAC3_uc009zpl.2_5'UTR|STAC3_uc001snq.2_Silent_p.I147I|STAC3_uc010srm.1_5'UTR	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	186					intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						TGTTTGCCATGATCACCCCAG	0.507													74	117					0	0	0.000781405	0	0
SRGAP1	57522	broad.mit.edu	37	12	64519840	64519840	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:64519840C>T	uc010ssp.1	+	19	2364	c.2308C>T	c.(2308-2310)CTG>TTG	p.L770L	SRGAP1_uc001srv.2_Silent_p.L707L	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	770	SH3.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		GGGTGCCTCCCTGCTGCTGTA	0.522													40	60					0	0	0.00195071	0	0
MDM2	4193	broad.mit.edu	37	12	69207352	69207352	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:69207352C>T	uc001sui.2	+	3	405	c.118C>T	c.(118-120)CTT>TTT	p.L40F	MDM2_uc009zri.2_Missense_Mutation_p.L40F|MDM2_uc009zqx.2_Missense_Mutation_p.L40F|MDM2_uc009zqw.2_Missense_Mutation_p.L40F|MDM2_uc001suk.2_Missense_Mutation_p.L40F|MDM2_uc009zqy.1_Missense_Mutation_p.L29F|MDM2_uc001sun.3_Missense_Mutation_p.L29F|MDM2_uc009zqz.2_Missense_Mutation_p.L34F|MDM2_uc009zra.2_Missense_Mutation_p.L34F|MDM2_uc009zrb.1_RNA|MDM2_uc001sum.1_Missense_Mutation_p.L29F|MDM2_uc009zrd.2_Intron|MDM2_uc009zrc.2_5'UTR|MDM2_uc009zre.2_Missense_Mutation_p.L29F|MDM2_uc009zrf.2_Intron|MDM2_uc001suo.2_Intron|MDM2_uc009zrg.2_Intron|MDM2_uc009zrh.2_Intron	NM_002392	NP_002383	Q00987	MDM2_HUMAN	mouse double minute 2 homolog isoform MDM2	34	Necessary for interaction with USP2.|SWIB.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			AAAGCCATTGCTTTTGAAGTT	0.348			A		sarcoma|glioma|colorectal|other								58	116					0	0	0.000781405	0	0
LGR5	8549	broad.mit.edu	37	12	71966646	71966646	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:71966646G>A	uc001swl.2	+	13	1201	c.1153G>A	c.(1153-1155)GAA>AAA	p.E385K	LGR5_uc001swm.2_Missense_Mutation_p.E361K|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	385	LRR 14.|Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						AAGACATAATGAAATCTACGA	0.413													113	244					0	0	0.000781405	0	0
TMTC3	160418	broad.mit.edu	37	12	88586521	88586521	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:88586521C>T	uc001tau.2	+	13	2067	c.1847C>T	c.(1846-1848)GCC>GTC	p.A616V		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	616	TPR 6.					integral to membrane	binding			skin(1)	1						CCAAATGAAGCCCTAAAAAAC	0.343													33	80					0	0	0.00283554	0	0
SLC17A8	246213	broad.mit.edu	37	12	100774536	100774536	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:100774536G>A	uc010svi.1	+	2	472	c.159G>A	c.(157-159)AGG>AGA	p.R53R	SLC17A8_uc009ztx.2_Silent_p.R53R	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	53	Cytoplasmic (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						AAGAAGGAAGGCCGGTGCAGA	0.502													61	117					0	0	0.000781405	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686135	108686135	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:108686135G>C	uc009zuw.2	-	3	796	c.605C>G	c.(604-606)TCG>TGG	p.S202W	CMKLR1_uc001tmw.2_Missense_Mutation_p.S202W|CMKLR1_uc001tmv.2_Missense_Mutation_p.S200W|CMKLR1_uc009zuv.2_Missense_Mutation_p.S202W	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	202	Extracellular (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						AGTGGGCCACGAGGAAGACCC	0.567													4	63					0	0	0.00024832	0	0
SART3	9733	broad.mit.edu	37	12	108917343	108917343	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:108917343G>A	uc001tmz.1	-	19	3018	c.2783C>T	c.(2782-2784)CCT>CTT	p.P928L	SART3_uc001tmy.1_Missense_Mutation_p.P454L|SART3_uc009zux.1_Missense_Mutation_p.P540L|SART3_uc010swx.1_Missense_Mutation_p.P892L	NM_014706	NP_055521	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T	928					RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			pancreas(1)	1						CTCAGCCTGAGGAGCTGCAGC	0.602									Porokeratosis				33	73					0	0	0.00178596	0	0
C12orf51	283450	broad.mit.edu	37	12	112654721	112654721	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:112654721G>A	uc009zwc.2	-	40	5993	c.5975C>T	c.(5974-5976)CCG>CTG	p.P1992L	C12orf51_uc001ttr.1_Missense_Mutation_p.P167L	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GTAAAAAGACGGGGCCTGAAG	0.473													32	76					0	0	0.000953801	0	0
C12orf51	283450	broad.mit.edu	37	12	112691863	112691863	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr12:112691863G>A	uc009zwc.2	-	15	2153	c.2135C>T	c.(2134-2136)CCG>CTG	p.P712L	C12orf51_uc010syk.1_Missense_Mutation_p.P544L|C12orf51_uc001tts.2_Missense_Mutation_p.P535L|C12orf51_uc001ttt.3_Missense_Mutation_p.P533L	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CAAGTCTTTCGGCCAACCAGT	0.458													37	77					0	0	0.00148497	0	0
LOC284232	284232	broad.mit.edu	37	13	19409926	19409926	+	RNA	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr13:19409926C>T	uc010tcj.1	-	1		c.36184G>A				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						TTTTCTTGTACCttttttttt	0.174													7	28					0	0	0.00198382	0	0
TPTE2	93492	broad.mit.edu	37	13	20004653	20004653	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr13:20004653C>T	uc001umd.2	-	18	1468	c.1257G>A	c.(1255-1257)ATG>ATA	p.M419I	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.M308I|TPTE2_uc001ume.2_Missense_Mutation_p.M342I|TPTE2_uc009zzm.2_Missense_Mutation_p.M90I|TPTE2_uc010tcm.1_RNA|TPTE2_uc010tcl.1_Missense_Mutation_p.M90I	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	419	C2 tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CCTTTTTCTCCATTACTACTT	0.328													14	30					0	0	0.00074312	0	0
RNF17	56163	broad.mit.edu	37	13	25367326	25367326	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr13:25367326C>T	uc001upr.2	+	10	1123	c.1082C>T	c.(1081-1083)CCT>CTT	p.P361L	RNF17_uc010tdd.1_Missense_Mutation_p.P220L|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.P361L|RNF17_uc001ups.2_Missense_Mutation_p.P300L|RNF17_uc001upq.1_Missense_Mutation_p.P361L	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	361				P -> S (in Ref. 1; AAK31981).	multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CCACCACCTCCTTTGCAACCT	0.408													67	150					0	0	0.000781405	0	0
FLT3	2322	broad.mit.edu	37	13	28588626	28588626	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr13:28588626G>A	uc001urw.2	-	23	2904	c.2822C>T	c.(2821-2823)TCG>TTG	p.S941L	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.S900L	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	941	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCCTAAAAACGAAGTCAAATT	0.388			Mis|O		AML|ALL								23	48					0	0	0.000586117	0	0
RXFP2	122042	broad.mit.edu	37	13	32367120	32367120	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr13:32367120G>A	uc001utt.2	+	16	1752	c.1681G>A	c.(1681-1683)GAT>AAT	p.D561N	RXFP2_uc010aba.2_Missense_Mutation_p.D520N	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	561	Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TTGGAATAAGGATTATTTTGG	0.368													14	48					0	0	0.00185496	0	0
SETDB2	83852	broad.mit.edu	37	13	50065897	50065897	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr13:50065897G>A	uc001vcz.2	+	15	2978	c.2072G>A	c.(2071-2073)TGG>TAG	p.W691*	SETDB2_uc001vda.2_Nonsense_Mutation_p.W679*	NM_031915	NP_114121	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2 isoform a	691	SET.				cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		GAGCTAACATGGGATTATGGC	0.313													25	38					0	0	0.00106085	0	0
GPC5	2262	broad.mit.edu	37	13	92345753	92345753	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr13:92345753G>A	uc010tif.1	+	3	1004	c.638G>A	c.(637-639)GGA>GAA	p.G213E		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	213						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AGAGTAATGGGACAGATGGGG	0.517													18	25					0	0	0.00074312	0	0
OR4K17	390436	broad.mit.edu	37	14	20585753	20585753	+	Missense_Mutation	SNP	C	T	T	rs150087607		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:20585753C>T	uc001vwo.1	+	1	188	c.188C>T	c.(187-189)TCG>TTG	p.S63L		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GCCCTCTTCTCGGTTATCTAT	0.408													62	187					0	0	0.000781405	0	0
RNF31	55072	broad.mit.edu	37	14	24618780	24618780	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:24618780A>T	uc001wmn.1	+	6	1046	c.797A>T	c.(796-798)CAC>CTC	p.H266L	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_Missense_Mutation_p.H115L|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.H81L|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	266	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		CAGGGTACCCACCTGAGCCCC	0.552													28	50					0	0	0.00127121	0	0
SSTR1	6751	broad.mit.edu	37	14	38678615	38678615	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:38678615C>T	uc001wul.1	+	3	638	c.21C>T	c.(19-21)GCC>GCT	p.A7A	SSTR1_uc010amu.1_RNA	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	7	Extracellular (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	ATGGCACCGCCTCCTCTCCTT	0.756													6	7					0	0	0.000274275	0	0
FANCM	57697	broad.mit.edu	37	14	45645573	45645573	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:45645573C>T	uc001wwd.3	+	14	3715	c.3616C>T	c.(3616-3618)CAG>TAG	p.Q1206*	FANCM_uc010anf.2_Nonsense_Mutation_p.Q1180*|FANCM_uc001wwe.3_Nonsense_Mutation_p.Q742*|FANCM_uc010ang.2_Nonsense_Mutation_p.Q420*	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1206					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						ATCTCGTGATCAGAGAGGTGT	0.353								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				25	55					0	0	0.000586117	0	0
RTN1	6252	broad.mit.edu	37	14	60194368	60194368	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:60194368G>A	uc001xen.1	-	3	1243	c.1034C>T	c.(1033-1035)TCC>TTC	p.S345F	RTN1_uc001xem.1_5'UTR	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	345					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TTTCCCCTGGGATTCTGCAGC	0.562													10	16					0	0	0.000978159	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713652	70713652	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:70713652C>T	uc010ttg.1	-	1	867	c.216G>A	c.(214-216)GTG>GTA	p.V72V		NR_003951				SubName: Full=ADAM21-like protein;												0						ACATGGAATCCACTATGTTGA	0.368													21	46					0	0	0.00229938	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73490959	73490959	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:73490959C>T	uc001xnm.2	-	2	898	c.258G>A	c.(256-258)CAG>CAA	p.Q86Q	ZFYVE1_uc010arj.2_Silent_p.Q86Q	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	86						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		CTATTGCCCTCTGCCTAACAC	0.517													81	144					0	0	0.000781405	0	0
ADCK1	57143	broad.mit.edu	37	14	78325425	78325425	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:78325425C>T	uc001xui.2	+	4	325	c.226C>T	c.(226-228)CTT>TTT	p.L76F	ADCK1_uc010tvo.1_RNA|ADCK1_uc001xuj.2_Intron|ADCK1_uc001xuk.1_5'UTR	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	83						extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		GCAGGTGCACCTTCGCTCTGC	0.597													31	90					0	0	0.00058488	0	0
KCNK10	54207	broad.mit.edu	37	14	88693821	88693821	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:88693821G>A	uc001xwo.2	-	4	1021	c.564C>T	c.(562-564)GCC>GCT	p.A188A	KCNK10_uc001xwm.2_Silent_p.A193A|KCNK10_uc001xwn.2_Silent_p.A193A	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	188	Helical; (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						TTCCAAAGATGGCATATAAAA	0.413													39	95					0	0	0.00170553	0	0
RIN3	79890	broad.mit.edu	37	14	93118452	93118452	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:93118452C>T	uc001yap.2	+	6	1210	c.1058C>T	c.(1057-1059)CCC>CTC	p.P353L	RIN3_uc010auk.2_Missense_Mutation_p.P15L|RIN3_uc001yaq.2_Missense_Mutation_p.P278L|RIN3_uc001yar.1_Missense_Mutation_p.P15L|RIN3_uc001yas.1_Missense_Mutation_p.P15L	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	353	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				GGCCTGGGCCCCCTCAGGGAG	0.667													13	25					0	0	0.00244969	0	0
ASB2	51676	broad.mit.edu	37	14	94401096	94401096	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:94401096C>T	uc001ycc.1	-	8	2159	c.1670G>A	c.(1669-1671)CGA>CAA	p.R557Q	ASB2_uc001ycb.1_Missense_Mutation_p.R251Q|ASB2_uc001ycd.2_Missense_Mutation_p.R605Q	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	557	SOCS box.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		AATGGCCTTTCGAACCCGCAG	0.488													26	55					0	0	0.000720815	0	0
DDX24	57062	broad.mit.edu	37	14	94521401	94521401	+	Nonsense_Mutation	SNP	T	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:94521401T>A	uc001ycj.2	-	7	2218	c.2119A>T	c.(2119-2121)AAG>TAG	p.K707*	DDX24_uc010twq.1_Nonsense_Mutation_p.K664*|DDX24_uc010twr.1_Nonsense_Mutation_p.K457*	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	707	Helicase C-terminal.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		TCATCTTTCTTGAGCGTTTTG	0.458													60	127					0	0	0.000781405	0	0
C14orf49	161176	broad.mit.edu	37	14	95899695	95899695	+	Missense_Mutation	SNP	G	A	A	rs141951711		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:95899695G>A	uc001yei.3	-	15	2605	c.2590C>T	c.(2590-2592)CGT>TGT	p.R864C	C14orf49_uc010avi.2_Missense_Mutation_p.R859C	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	864	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		GGCCCGAGACGAAGGAGGTTC	0.597													33	78					0	0	0.000692331	0	0
RTL1	388015	broad.mit.edu	37	14	101351047	101351047	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:101351047C>T	uc010txj.1	-	1	138	c.79G>A	c.(79-81)GAG>AAG	p.E27K	uc010txk.1_RNA|MIR136_hsa-mir-136|MI0000475_RNA	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	27										pancreas(1)	1						GATGAGCCCTCGGAGGACTCC	0.567													8	26					0	0	0.000157383	0	0
SIVA1	10572	broad.mit.edu	37	14	105222123	105222123	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:105222123G>A	uc001yph.2	+	2	344	c.275G>A	c.(274-276)GGC>GAC	p.G92D	INF2_uc010tyi.1_Intron|SIVA1_uc010tyj.1_Missense_Mutation_p.G92D|SIVA1_uc001ypg.1_Missense_Mutation_p.G92D|SIVA1_uc001ypi.2_Intron	NM_006427	NP_006418	O15304	SIVA_HUMAN	CD27-binding (Siva) protein isoform 1	92					activation of caspase activity by cytochrome c|activation-induced cell death of T cells|apoptosis|induction of apoptosis|interspecies interaction between organisms|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity	cytoplasm|mitochondrion|nucleoplasm|nucleus	caspase activator activity|CD27 receptor binding|metal ion binding|viral receptor activity|zinc ion binding				0		all_cancers(154;0.14)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.173)		GGACCAGACGGCCGCCTGATC	0.652													15	16					0	0	0.000422831	0	0
ADAM6	8755	broad.mit.edu	37	14	106641711	106641711	+	RNA	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:106641711C>T	uc010tyt.1	-	1021		c.24290G>A								Parts of antibodies, mostly variable regions.												0						GCTGATCCATCCCATCCACTC	0.542													68	153					0	0	0.000781405	0	0
ADAM6	8755	broad.mit.edu	37	14	106790942	106790942	+	RNA	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr14:106790942C>T	uc010tyt.1	-	387		c.14676G>A								Parts of antibodies, mostly variable regions.												0						CCGCTGATTTCCCGCCAGCGT	0.587													21	142					0	0	0.00278032	0	0
RYR3	6263	broad.mit.edu	37	15	33993274	33993274	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr15:33993274T>G	uc001zhi.2	+	42	6546	c.6476T>G	c.(6475-6477)CTC>CGC	p.L2159R	RYR3_uc010bar.2_Missense_Mutation_p.L2159R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2159	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAACCAGACCTCGAGAAGGTA	0.567											OREG0023030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	8					0	0	0.000274275	0	0
SPRED1	161742	broad.mit.edu	37	15	38614474	38614474	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr15:38614474C>T	uc001zka.3	+	3	575	c.240C>T	c.(238-240)CTC>CTT	p.L80L		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	80	WH1.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		AAAAAGACCTCATTTATAATA	0.338									Legius_syndrome				55	48					0	0	0.000781405	0	0
ANXA2	302	broad.mit.edu	37	15	60646353	60646354	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr15:60646353_60646354CC>TT	uc002agn.2	-	9	747_748	c.587_588GG>AA	c.(586-588)CGG>CAA	p.R196Q	ANXA2_uc002agk.2_Missense_Mutation_p.R196Q|ANXA2_uc002agl.2_Missense_Mutation_p.R196Q|ANXA2_uc002agm.2_Missense_Mutation_p.R214Q|ANXA2_uc010uhd.1_Intron	NM_001136015	NP_001129487	P07355	ANXA2_HUMAN	annexin A2 isoform 2	196					angiogenesis|positive regulation of vesicle fusion|skeletal system development	basement membrane|melanosome|midbody|soluble fraction	calcium ion binding|calcium-dependent phospholipid binding|cytoskeletal protein binding|phospholipase inhibitor activity			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Tenecteplase(DB00031)	CAGCACTTACCCGAGCATCTTG	0.317													14	7					0	0	6.4e-05	0	0
LARP6	55323	broad.mit.edu	37	15	71124689	71124689	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr15:71124689G>A	uc002ass.2	-	3	1249	c.1178C>T	c.(1177-1179)TCC>TTC	p.S393F		NM_018357	NP_060827	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	393					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0						GGACTTTCTGGAAACGCCTTT	0.562													38	39					0	0	0.00111076	0	0
AEN	64782	broad.mit.edu	37	15	89172573	89172573	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr15:89172573C>G	uc002bmt.2	+	3	808	c.657C>G	c.(655-657)AAC>AAG	p.N219K	AEN_uc010bnm.1_Missense_Mutation_p.N219K	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	219	Exonuclease.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						ATGTCCCAAACTTCCTCAGCG	0.642													51	32					0	0	0.000781405	0	0
AEN	64782	broad.mit.edu	37	15	89172601	89172601	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr15:89172601C>T	uc002bmt.2	+	3	836	c.685C>T	c.(685-687)CGG>TGG	p.R229W	AEN_uc010bnm.1_Missense_Mutation_p.R229W	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	229	Exonuclease.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						CCTCCACACCCGGGCCCGGGT	0.647													39	36					0	0	0.000781405	0	0
BLM	641	broad.mit.edu	37	15	91312735	91312736	+	Missense_Mutation	DNP	CG	AT	AT	rs147587050	byFrequency	TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr15:91312735_91312736CG>AT	uc002bpr.2	+	12	2571_2572	c.2474_2475CG>AT	c.(2473-2475)CCG>CAT	p.P825H	BLM_uc010uqh.1_Missense_Mutation_p.P825H|BLM_uc010uqi.1_Missense_Mutation_p.P450H|BLM_uc010bnx.2_Missense_Mutation_p.P825H|BLM_uc002bps.1_Missense_Mutation_p.P387H	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	825	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			CCTTCTGTTCCGGTGATGGCTC	0.446			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				9	698					0	0	6.4e-05	0	0
MCTP2	55784	broad.mit.edu	37	15	94841704	94841704	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr15:94841704G>A	uc002btj.2	+	1	275	c.210G>A	c.(208-210)GGG>GGA	p.G70G	MCTP2_uc010urg.1_Silent_p.G70G|MCTP2_uc002bti.2_Silent_p.G70G|MCTP2_uc010boj.2_5'UTR|MCTP2_uc010bok.2_Silent_p.G70G|MCTP2_uc002btg.3_Silent_p.G70G|MCTP2_uc002bth.3_Silent_p.G70G	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	70					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CTTACTCCGGGCCACAGTCTT	0.592													60	27					0	0	0.000781405	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100537734	100537734	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr15:100537734C>T	uc002bvv.1	-	19	2731	c.2652G>A	c.(2650-2652)CGG>CGA	p.R884R		NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	884	TSP type-1 3.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		AGGTCACCTCCCGGTGCTGGA	0.567													30	22					0	0	0.00209593	0	0
MSLNL	401827	broad.mit.edu	37	16	824291	824291	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:824291G>A	uc002cjz.1	-	9	1865	c.1865C>T	c.(1864-1866)TCG>TTG	p.S622L		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	271	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						CACCTGGCACGAAGCCACCAC	0.697													6	3					0	0	0.00116845	0	0
RPUSD1	113000	broad.mit.edu	37	16	836346	836346	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:836346A>C	uc002cka.2	-	5	777	c.543T>G	c.(541-543)AGT>AGG	p.S181R	RPUSD1_uc002ckb.2_Missense_Mutation_p.S181R|RPUSD1_uc002ckc.2_Missense_Mutation_p.S52R|RPUSD1_uc002ckd.2_3'UTR|CHTF18_uc010uus.1_5'Flank|CHTF18_uc010bre.1_5'Flank|CHTF18_uc002cke.3_5'Flank|CHTF18_uc002ckf.3_5'Flank|CHTF18_uc010brf.2_5'Flank|CHTF18_uc002ckg.3_5'Flank	NM_058192	NP_478072	Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing	181					pseudouridine synthesis		pseudouridine synthase activity|RNA binding				0		Hepatocellular(780;0.00335)				GGCCCAGGGCACTGCAGTGCA	0.677													20	19					0	0	0.00229938	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1816261	1816261	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:1816261C>T	uc002cmk.2	+	22	2787	c.2667C>T	c.(2665-2667)TCC>TCT	p.S889S	MAPK8IP3_uc002cml.2_Silent_p.S883S|MAPK8IP3_uc010uvl.1_Silent_p.S890S	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	889					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						TCAACCCGTCCCAGTCCACAG	0.657													20	23					0	0	0.00121646	0	0
SRRM2	23524	broad.mit.edu	37	16	2814310	2814310	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:2814310A>G	uc002crk.2	+	11	4330	c.3781A>G	c.(3781-3783)AAA>GAA	p.K1261E	SRRM2_uc002crj.1_Missense_Mutation_p.K1165E|SRRM2_uc002crl.1_Missense_Mutation_p.K1261E|SRRM2_uc010bsu.1_Missense_Mutation_p.K1165E	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1261	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TTCAGAACTTAAAGAAATGTC	0.443													80	69					0	0	0.000781405	0	0
OR1F1	4992	broad.mit.edu	37	16	3254567	3254567	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:3254567C>T	uc010uwu.1	+	1	321	c.321C>T	c.(319-321)TTC>TTT	p.F107F		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTTTCATGTTCGTGGACATGG	0.502													59	66					0	0	0.000781405	0	0
FAM57B	83723	broad.mit.edu	37	16	30037138	30037138	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:30037138C>T	uc002dvt.2	-	4	787	c.449G>A	c.(448-450)TGG>TAG	p.W150*	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|FAM57B_uc002dvu.2_Nonsense_Mutation_p.W100*	NM_031478	NP_113666	Q71RH2	FA57B_HUMAN	hypothetical protein LOC83723	150	TLC.|Helical; (Potential).					endoplasmic reticulum|integral to membrane					0						ACCCTGTCGCCACACCTGGGC	0.597													47	67					0	0	0.0025221	0	0
SETD1A	9739	broad.mit.edu	37	16	30976109	30976109	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:30976109C>T	uc002ead.1	+	7	1732	c.1046C>T	c.(1045-1047)TCG>TTG	p.S349L		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	349	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						tcgtcctcctcgtcatcctct	0.368													80	97					0	0	0.000781405	0	0
ABCC12	94160	broad.mit.edu	37	16	48177954	48177954	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:48177954C>T	uc002efc.1	-	2	488	c.142G>A	c.(142-144)GAT>AAT	p.D48N	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Missense_Mutation_p.D48N|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	48						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				AGCCCGGCATCATCCACCGGG	0.567													13	28					0	0	0.000422831	0	0
ABCC11	85320	broad.mit.edu	37	16	48226485	48226485	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:48226485G>A	uc002eff.1	-	19	3002	c.2652C>T	c.(2650-2652)TTC>TTT	p.F884F	ABCC11_uc002efg.1_Silent_p.F884F|ABCC11_uc002efh.1_Silent_p.F884F|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	884	Helical; (Potential).|ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TGACCTTGGTGAAAATCCCTG	0.577									Cerumen_Type				30	33					0	0	0.00127121	0	0
NKD1	85407	broad.mit.edu	37	16	50664200	50664200	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:50664200C>T	uc002egg.1	+	7	790	c.566C>T	c.(565-567)CCC>CTC	p.P189L		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	189	Interaction with DVL1, DVL2 and DVL3 (By similarity).				Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		ACCGTGGCCCCCGATGGCAGC	0.582													21	18					0	0	0.000586117	0	0
CES1	1066	broad.mit.edu	37	16	55855423	55855423	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:55855423C>T	uc002eim.2	-	5	655	c.547G>A	c.(547-549)GAA>AAA	p.E183K	CES1_uc002eil.2_Missense_Mutation_p.E184K|CES1_uc002ein.2_Missense_Mutation_p.E183K	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	183					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	CGGCTGTGTTCATCCCCTGTG	0.602													16	14					0	0	0.00074312	0	0
NFATC3	4775	broad.mit.edu	37	16	68156318	68156318	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:68156318G>A	uc002evo.1	+	2	742	c.532G>A	c.(532-534)GAT>AAT	p.D178N	NFATC3_uc010vkl.1_5'UTR|NFATC3_uc010vkm.1_5'UTR|NFATC3_uc010vkn.1_5'UTR|NFATC3_uc010vko.1_5'UTR|NFATC3_uc010vkp.1_5'UTR|NFATC3_uc010vkq.1_5'UTR|NFATC3_uc002evl.2_Intron|NFATC3_uc002evk.2_Missense_Mutation_p.D178N|NFATC3_uc002evm.1_Missense_Mutation_p.D178N|NFATC3_uc002evn.1_Missense_Mutation_p.D178N|NFATC3_uc010vkr.1_5'UTR|NFATC3_uc010vks.1_5'UTR|NFATC3_uc010vkt.1_5'UTR|NFATC3_uc010vku.1_5'UTR|NFATC3_uc010vkv.1_5'UTR|NFATC3_uc010vkw.1_5'UTR|NFATC3_uc010vkx.1_5'UTR|NFATC3_uc010vky.1_5'UTR|NFATC3_uc010vkz.1_5'UTR|NFATC3_uc010vla.1_5'UTR|NFATC3_uc010vlb.1_5'UTR|NFATC3_uc010vlc.1_5'UTR	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	178					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TTGGTTCTCTGATGCATCTTC	0.463													35	35					0	0	0.00058488	0	0
ADAT1	23536	broad.mit.edu	37	16	75646172	75646173	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:75646172_75646173GG>AA	uc002feo.1	-	7	1113_1114	c.1011_1012CC>TT	c.(1009-1014)AGCCAG>AGTTAG	p.Q338*	ADAT1_uc002fep.1_Nonsense_Mutation_p.Q189*	NM_012091	NP_036223	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	338	A to I editase.				tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			ovary(1)|skin(1)	2						ATGGCTTCCTGGCTGTATGGGC	0.401													21	30					0	0	6.4e-05	0	0
PKD1L2	114780	broad.mit.edu	37	16	81175102	81175102	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr16:81175102C>T	uc002fgh.1	-	31	5217	c.5217G>A	c.(5215-5217)GCG>GCA	p.A1739A	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1739	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CACTCCGTGCCGCCTTGGGCT	0.557													6	8					0	0	0.00198382	0	0
ZNF232	7775	broad.mit.edu	37	17	5012287	5012287	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:5012287C>T	uc002gas.2	-	4	1232	c.478G>A	c.(478-480)GGA>AGA	p.G160R	ZNF232_uc002gar.1_Missense_Mutation_p.G187R|ZNF232_uc002gat.2_Missense_Mutation_p.G187R|ZNF232_uc010vsv.1_3'UTR	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	160					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TGGGCTGCTCCCAGAGATTCC	0.552													53	63					0	0	0.000781405	0	0
TP53	7157	broad.mit.edu	37	17	7579329	7579329	+	Missense_Mutation	SNP	T	C	C	rs121912658		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:7579329T>C	uc002gim.2	-	4	552	c.358A>G	c.(358-360)AAG>GAG	p.K120E	TP53_uc002gig.1_Missense_Mutation_p.K120E|TP53_uc002gih.2_Missense_Mutation_p.K120E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.K120E|TP53_uc010cni.1_Missense_Mutation_p.K120E|TP53_uc002gij.2_Missense_Mutation_p.K120E|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.K81E|TP53_uc010cnk.1_Missense_Mutation_p.K135E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	120	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Interaction with DNA.	K -> R (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> Q (in a sporadic cancer; somatic mutation).|K -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.K120E(3)|p.G59fs*23(3)|p.K120R(2)|p.K120M(2)|p.K120*(2)|p.K120fs*3(2)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G112_V122delGFLHSGTAKSV(1)|p.T118fs*27(1)|p.H115fs*27(1)|p.K120N(1)|p.Y107fs*44(1)|p.K120Q(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCACAGACTTGGCTGTCCCA	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			34	32					0	0	0.00058488	0	0
MYH1	4619	broad.mit.edu	37	17	10399767	10399767	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:10399767C>T	uc002gmo.2	-	34	4850	c.4756G>A	c.(4756-4758)GAA>AAA	p.E1586K	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1586	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TGGTCAATTTCCTCATCTTTT	0.453													65	56					0	0	0.000781405	0	0
LOC162632	162632	broad.mit.edu	37	17	16705752	16705752	+	RNA	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:16705752C>T	uc010cpj.1	+	21		c.5069C>T			LOC162632_uc010cpk.1_RNA|LOC162632_uc002gqm.2_RNA					Homo sapiens mRNA for KIAA0565 protein, partial cds.												0						AGCAAAGCTACCACTCTGGCT	0.433													9	38					0	0	0.000673444	0	0
SYNRG	11276	broad.mit.edu	37	17	35880722	35880722	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:35880722G>A	uc002hoa.2	-	20	3779	c.3696C>T	c.(3694-3696)TCC>TCT	p.S1232S	SYNRG_uc010wde.1_Silent_p.S1177S|SYNRG_uc010wdf.1_Silent_p.S1154S|SYNRG_uc002hoc.2_Silent_p.S1153S|SYNRG_uc002hoe.2_Silent_p.S1154S|SYNRG_uc002hod.2_Silent_p.S1109S|SYNRG_uc010wdg.1_Silent_p.S1026S|SYNRG_uc002hob.2_Silent_p.S1232S	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	1232					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						GTAACATACAGGAGGAAAAAT	0.512													28	31					0	0	0.00283554	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40836075	40836076	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:40836075_40836076GG>AA	uc002iay.2	+	3	407_408	c.191_192GG>AA	c.(190-192)CGG>CAA	p.R64Q	CCR10_uc002iax.3_5'Flank|CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	64	Extracellular (Potential).|F5/8 type C.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		TGGTCACCACGGATTGGGGATC	0.594													40	42					0	0	6.4e-05	0	0
MPP2	4355	broad.mit.edu	37	17	41958487	41958487	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:41958487C>T	uc010wip.1	-	9	1151	c.1094G>A	c.(1093-1095)CGA>CAA	p.R365Q	MPP2_uc002ien.1_Missense_Mutation_p.R337Q|MPP2_uc010wim.1_Missense_Mutation_p.R309Q|MPP2_uc002ieo.1_Missense_Mutation_p.R320Q|MPP2_uc010win.1_Missense_Mutation_p.R181Q|MPP2_uc010wio.1_Missense_Mutation_p.R309Q	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	344					signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		ATACATCATTCGCTTCTTTTT	0.557											OREG0024443	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	62	67					0	0	0.000781405	0	0
GFAP	2670	broad.mit.edu	37	17	42992742	42992742	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:42992742G>A	uc002ihq.2	-	1	173	c.113C>T	c.(112-114)TCC>TTC	p.S38F	GFAP_uc002ihr.2_Missense_Mutation_p.S38F|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	38	Head.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				TCGAGCCAGGGAGAGGCGGGT	0.692													15	13					0	0	0.000308642	0	0
CACNA1G	8913	broad.mit.edu	37	17	48692763	48692763	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:48692763C>T	uc002irk.1	+	27	5173	c.4801C>T	c.(4801-4803)CGG>TGG	p.R1601W	CACNA1G_uc002irj.1_Missense_Mutation_p.R1567W|CACNA1G_uc002irl.1_Missense_Mutation_p.R1578W|CACNA1G_uc002irm.1_Missense_Mutation_p.R1567W|CACNA1G_uc002irn.1_Missense_Mutation_p.R1560W|CACNA1G_uc002iro.1_Missense_Mutation_p.R1567W|CACNA1G_uc002irp.1_Missense_Mutation_p.R1601W|CACNA1G_uc002irq.1_Missense_Mutation_p.R1578W|CACNA1G_uc002irr.1_Missense_Mutation_p.R1601W|CACNA1G_uc002irs.1_Missense_Mutation_p.R1590W|CACNA1G_uc002irt.1_Missense_Mutation_p.R1583W|CACNA1G_uc002irv.1_Missense_Mutation_p.R1590W|CACNA1G_uc002irw.1_Missense_Mutation_p.R1578W|CACNA1G_uc002iru.1_Missense_Mutation_p.R1567W|CACNA1G_uc002irx.1_Missense_Mutation_p.R1514W|CACNA1G_uc002iry.1_Missense_Mutation_p.R1503W|CACNA1G_uc002irz.1_Missense_Mutation_p.R1514W|CACNA1G_uc002isa.1_Missense_Mutation_p.R1480W|CACNA1G_uc002isb.1_Missense_Mutation_p.R1521W|CACNA1G_uc002isc.1_Missense_Mutation_p.R1503W|CACNA1G_uc002isd.1_Missense_Mutation_p.R1496W|CACNA1G_uc002ise.1_Missense_Mutation_p.R1469W|CACNA1G_uc002isf.1_Missense_Mutation_p.R1496W|CACNA1G_uc002isg.1_Missense_Mutation_p.R1462W|CACNA1G_uc002ish.1_Missense_Mutation_p.R1469W|CACNA1G_uc002isi.1_Missense_Mutation_p.R1457W	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1601	IV.|Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CTCCCGCTTCCGGCTCCTCGT	0.622													19	17					0	0	0.00152264	0	0
CLTC	1213	broad.mit.edu	37	17	57760513	57760513	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:57760513C>G	uc002ixq.1	+	25	4374	c.3931C>G	c.(3931-3933)CGA>GGA	p.R1311G	CLTC_uc002ixp.2_Missense_Mutation_p.R1311G|CLTC_uc002ixr.1_Missense_Mutation_p.R1315G	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	1311	Heavy chain arm.|Proximal segment.|Involved in binding clathrin light chain (By similarity).				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GGGACTTGAGCGAGCTCACAT	0.418			T	ALK|TFE3	ALCL|renal 								29	23					0	0	0.001512	0	0
ENGASE	64772	broad.mit.edu	37	17	77082173	77082173	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:77082173C>T	uc002jwv.2	+	14	1982	c.1974C>T	c.(1972-1974)GTC>GTT	p.V658V	ENGASE_uc002jww.2_Silent_p.V363V	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	658						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						TCTCACAAGTCCGTTGCTTCC	0.637													25	34					0	0	0.000720815	0	0
ENPP7	339221	broad.mit.edu	37	17	77709027	77709027	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:77709027C>T	uc002jxa.2	+	3	605	c.585C>T	c.(583-585)TTC>TTT	p.F195F		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	195					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CACTCTACTTCGGGGAGCCGG	0.622													10	18					0	0	0.00136819	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995826	19995826	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:19995826G>A	uc002ktv.1	-	1	2053	c.1949C>T	c.(1948-1950)CCC>CTC	p.P650L		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	650						integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					ATTTTCAGCGGGGAGAGATGA	0.428													60	167					0	0	0.000781405	0	0
LAMA3	3909	broad.mit.edu	37	18	21444815	21444815	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:21444815C>T	uc002kuq.2	+	36	4737	c.4651C>T	c.(4651-4653)CTT>TTT	p.L1551F	LAMA3_uc002kur.2_Missense_Mutation_p.L1551F	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1551	Laminin IV type A.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGACATGGTTCTTCTGGAAAA	0.453													35	64					0	0	0.00170553	0	0
DSG3	1830	broad.mit.edu	37	18	29046501	29046501	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:29046501G>A	uc002kws.2	+	11	1529	c.1420G>A	c.(1420-1422)GGT>AGT	p.G474S		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	474	Cadherin 4.|Extracellular (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGAATACACGGGTAAAACTTC	0.358													31	75					0	0	0.00209593	0	0
ASXL3	80816	broad.mit.edu	37	18	31323920	31323920	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:31323920C>T	uc010dmg.1	+	12	4163	c.4108C>T	c.(4108-4110)CCT>TCT	p.P1370S	ASXL3_uc002kxq.2_Missense_Mutation_p.P1077S	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CAACAGATTTCCTTCTGAGAA	0.498											OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	95					0	0	0.000680045	0	0
FHOD3	80206	broad.mit.edu	37	18	34081944	34081944	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:34081944C>T	uc002kzt.1	+	4	484	c.387C>T	c.(385-387)TCC>TCT	p.S129S	FHOD3_uc002kzr.1_Silent_p.S129S|FHOD3_uc002kzs.1_Silent_p.S129S	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	129	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CCCTCTTCTCCCTGAAGCAGA	0.338													5	8					0	0	0.000157383	0	0
CELF4	56853	broad.mit.edu	37	18	34853100	34853100	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:34853100C>T	uc002lae.2	-	7	1224	c.828G>A	c.(826-828)ATG>ATA	p.M276I	CELF4_uc010dnd.1_Missense_Mutation_p.M274I|CELF4_uc002lag.2_Missense_Mutation_p.M266I|CELF4_uc002laf.2_Missense_Mutation_p.M271I|CELF4_uc002lai.2_Missense_Mutation_p.M261I|CELF4_uc002lah.1_Missense_Mutation_p.M1I|CELF4_uc002laj.1_Missense_Mutation_p.G112S	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	276	Sufficient for RNA-binding and MSE- dependent splicing activity.|Ala-rich.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						CGACTGATGCCATCAGGGCCG	0.652													19	52					0	0	0.00152264	0	0
PIAS2	9063	broad.mit.edu	37	18	44426691	44426691	+	Silent	SNP	A	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:44426691A>C	uc002lck.2	-	6	998	c.840T>G	c.(838-840)TCT>TCG	p.S280S	PIAS2_uc010dnp.2_5'UTR|PIAS2_uc002lcl.2_Silent_p.S280S|PIAS2_uc010xda.1_5'UTR|PIAS2_uc002lcm.2_Silent_p.S280S|PIAS2_uc002lcn.1_Silent_p.S284S	NM_004671	NP_004662	O75928	PIAS2_HUMAN	protein inhibitor of activated STAT X isoform	280	PINIT.				androgen receptor signaling pathway|negative regulation of androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|PML body	androgen receptor binding|DNA binding|protein binding|SUMO ligase activity|transcription coactivator activity|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						CTGATGCCCAAGAAATGGAAA	0.448													24	73					0	0	0.00278032	0	0
CCDC11	220136	broad.mit.edu	37	18	47792804	47792804	+	Translation_Start_Site	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:47792804G>A	uc002lee.2	-	1	62	c.-29C>T	c.(-31--27)GACGC>GATGC			NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11											ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		CGGGGGCGGCGTCCGCCGCGT	0.672													12	55					0	0	0.00136819	0	0
CDH20	28316	broad.mit.edu	37	18	59206330	59206330	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:59206330C>T	uc010dps.1	+	8	1494	c.1482C>T	c.(1480-1482)TTC>TTT	p.F494F	CDH20_uc002lif.2_Silent_p.F488F	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	494	Cadherin 4.|Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				CTCCAGAGTTCCCCAGATTCT	0.473													52	92					0	0	0.000781405	0	0
PLIN5	440503	broad.mit.edu	37	19	4529248	4529248	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:4529248C>T	uc002mas.2	-	5	410	c.357G>A	c.(355-357)AAG>AAA	p.K119K	PLIN5_uc002mat.1_3'UTR	NM_001013706	NP_001013728	Q00G26	PLIN5_HUMAN	lipid storage droplet protein 5	119						lipid particle					0						CCACCACGTCCTTGGCTGAGG	0.527													30	27					0	0	0.0024448	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455836	5455836	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:5455836G>A	uc002mca.3	+	1	411	c.334G>A	c.(334-336)GAC>AAC	p.D112N		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	112	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GAGCTCGGTGGACTTTGCGGA	0.662													43	30					0	0	0.000781405	0	0
MUC16	94025	broad.mit.edu	37	19	9019292	9019292	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:9019292G>A	uc002mkp.2	-	23	37799	c.37595C>T	c.(37594-37596)TCC>TTC	p.S12532F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12534	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTTGGGAGGGAGAATGGAGT	0.458													12	19					0	0	0.00136819	0	0
TYK2	7297	broad.mit.edu	37	19	10476451	10476451	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:10476451G>A	uc002moc.3	-	7	1131	c.753C>T	c.(751-753)TCC>TCT	p.S251S	TYK2_uc010dxe.2_Silent_p.S66S|TYK2_uc002mod.2_Silent_p.S251S	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	251	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCATCTGCTGGGAGAGTCGGC	0.677													7	8					0	0	0.000157383	0	0
NWD1	284434	broad.mit.edu	37	19	16908678	16908678	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:16908678C>T	uc002neu.3	+	16	3862	c.3440C>T	c.(3439-3441)TCC>TTC	p.S1147F	NWD1_uc002net.3_Missense_Mutation_p.S1012F|NWD1_uc002nev.3_Missense_Mutation_p.S941F			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	1147	WD 8.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						ATCACGGGGTCCCTTGATGCG	0.522													85	89					0	0	0.000781405	0	0
RYR1	6261	broad.mit.edu	37	19	38956933	38956933	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:38956933C>T	uc002oit.2	+	24	3203	c.3073C>T	c.(3073-3075)CTG>TTG	p.L1025L	RYR1_uc002oiu.2_Silent_p.L1025L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1025	6 X approximate repeats.|2.|Cytoplasmic.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCCCTACCGCCTGCTGGATGA	0.682													5	5					0	0	0.000602214	0	0
MEGF8	1954	broad.mit.edu	37	19	42839497	42839497	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:42839497C>T	uc002otl.3	+	5	1423	c.788C>T	c.(787-789)TCC>TTC	p.S263F	MEGF8_uc002otm.3_5'Flank	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	263	Extracellular (Potential).|Kelch 1.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				TACAACTTCTCCGCCAACACC	0.627													25	65					0	0	0.00106085	0	0
PNMAL2	57469	broad.mit.edu	37	19	46998608	46998608	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:46998608G>A	uc002pes.2	-	1	562	c.115C>T	c.(115-117)CTG>TTG	p.L39L	uc002peu.1_3'UTR	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	39										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		gtcggctgcaggacggcttcg	0													38	50					0	0	0.00148497	0	0
CPT1C	126129	broad.mit.edu	37	19	50208316	50208316	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:50208316C>T	uc002ppj.2	+	8	1029	c.824C>T	c.(823-825)GCC>GTC	p.A275V	CPT1C_uc002ppl.3_Missense_Mutation_p.A241V|CPT1C_uc002ppi.2_Missense_Mutation_p.A192V|CPT1C_uc002ppk.2_Missense_Mutation_p.A264V|CPT1C_uc010eng.2_Missense_Mutation_p.A275V|CPT1C_uc010enh.2_Missense_Mutation_p.A275V|CPT1C_uc010ybc.1_Missense_Mutation_p.A113V|CPT1C_uc010eni.1_5'Flank	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	275	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GCTGGGAATGCCGTCCATGCC	0.647													21	44					0	0	0.00188189	0	0
KLK5	25818	broad.mit.edu	37	19	51446990	51446990	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:51446990G>A	uc002pue.2	-	7	997	c.779C>T	c.(778-780)TCC>TTC	p.S260F	KLK5_uc002puf.2_Missense_Mutation_p.S260F|KLK5_uc002pug.2_Missense_Mutation_p.S260F	NM_001077491	NP_001070959	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5 preproprotein	260	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		ATCTCCCCAGGACACGAGTCC	0.478													23	40					0	0	0.00229938	0	0
KLK11	11012	broad.mit.edu	37	19	51527935	51527935	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:51527935G>A	uc002pvd.1	-	3	364	c.252C>T	c.(250-252)ATC>ATT	p.I84I	KLK11_uc002pvb.1_Silent_p.I52I|KLK11_uc002pve.1_5'UTR|KLK11_uc002pvf.1_Silent_p.I52I|KLK11_uc002pvc.3_Silent_p.I52I|KLK11_uc010eom.2_Silent_p.I52I	NM_144947	NP_659196	Q9UBX7	KLK11_HUMAN	kallikrein 11 isoform 2 precursor	84	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|GBM - Glioblastoma multiforme(134;0.00878)		ATCTGGGGGCGATGAGCGTCG	0.453													4	13					0	0	0.00024832	0	0
LILRB3	11025	broad.mit.edu	37	19	54724986	54724986	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:54724986G>A	uc002qef.1	-	5	1035	c.924C>T	c.(922-924)GCC>GCT	p.A308A	LILRB3_uc002qee.1_Silent_p.A308A|LILRB3_uc002qeh.1_Silent_p.A308A|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Silent_p.A308A|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Silent_p.A308A|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Silent_p.A308A|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Silent_p.A308A|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	308	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGTCGCTGGGGGCCGACCACT	0.682													17	12					0	0	0.00152264	0	0
NCR1	9437	broad.mit.edu	37	19	55420724	55420724	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:55420724G>A	uc002qib.2	+	4	514	c.476G>A	c.(475-477)GGA>GAA	p.G159E	NCR1_uc002qic.2_Missense_Mutation_p.G159E|NCR1_uc002qie.2_Missense_Mutation_p.G159E|NCR1_uc002qid.2_Missense_Mutation_p.G64E|NCR1_uc002qif.2_Missense_Mutation_p.G64E|NCR1_uc010esj.2_Missense_Mutation_p.G52E	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	159	Extracellular (Potential).|Ig-like 2.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		CTCAAGGAGGGAAGATCCAGC	0.582													26	43					0	0	0.000586117	0	0
NLRP2	55655	broad.mit.edu	37	19	55505685	55505685	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:55505685G>A	uc002qij.2	+	11	2843	c.2757G>A	c.(2755-2757)AAG>AAA	p.K919K	NLRP2_uc010yfp.1_Silent_p.K896K|NLRP2_uc010esn.2_Silent_p.K895K|NLRP2_uc010eso.2_Silent_p.K916K|NLRP2_uc010esp.2_Silent_p.K897K	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	919					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ATCTCACAAAGCTTCTCCAAG	0.468													36	109					0	0	0.00148497	0	0
PEG3	5178	broad.mit.edu	37	19	57335908	57335908	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:57335908G>A	uc002qnu.2	-	1	467	c.116C>T	c.(115-117)CCA>CTA	p.P39L	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.P39L|PEG3_uc002qnv.2_Missense_Mutation_p.P39L|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Missense_Mutation_p.P39L	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	39					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGAGTCAGTTGGACCTTCTCC	0.483													27	56					0	0	0.000720815	0	0
ZNF154	7710	broad.mit.edu	37	19	58213359	58213359	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr19:58213359G>A	uc010euf.2	-	3	1198	c.958C>T	c.(958-960)CAT>TAT	p.H320Y	ZNF776_uc002qpx.2_Intron|ZNF154_uc002qpy.2_RNA	NM_001085384	NP_001078853	Q13106	ZN154_HUMAN	zinc finger protein 154	320	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGAACCCTATGGTGTTCAATG	0.473													23	52					0	0	0.00188189	0	0
GPR113	165082	broad.mit.edu	37	2	26533850	26533850	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:26533850C>T	uc002rhe.3	-	11	2746	c.2746G>A	c.(2746-2748)GAA>AAA	p.E916K	GPR113_uc010yky.1_Missense_Mutation_p.E847K|GPR113_uc002rhb.1_Missense_Mutation_p.E519K|GPR113_uc010eyk.1_Missense_Mutation_p.E717K|GPR113_uc002rhc.1_Missense_Mutation_p.E519K|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	916	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AACCAGCATTCCCCCTCCCTC	0.612													4	8					0	0	0.00198382	0	0
SLC5A6	8884	broad.mit.edu	37	2	27424713	27424713	+	Silent	SNP	A	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:27424713A>C	uc002rjd.2	-	14	1756	c.1365T>G	c.(1363-1365)GGT>GGG	p.G455G	SLC5A6_uc010eyv.1_Silent_p.G455G	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	455					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	CCACAACAGCACCCTGCCGAG	0.642													6	15					0	0	0.000442599	0	0
CAPN13	92291	broad.mit.edu	37	2	30985998	30985998	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:30985998C>T	uc002rnn.2	-	7	900	c.724G>A	c.(724-726)GAG>AAG	p.E242K	CAPN13_uc002rnp.1_Missense_Mutation_p.E242K	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	242	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AGCCCATTCTCCATCGCCTGT	0.517													10	5					0	0	0.00185496	0	0
SPAST	6683	broad.mit.edu	37	2	32352039	32352039	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:32352039C>T	uc002roc.2	+	8	1342	c.1121C>T	c.(1120-1122)CCT>CTT	p.P374L	SPAST_uc002rod.2_Missense_Mutation_p.P342L	NM_014946	NP_055761	Q9UBP0	SPAST_HUMAN	spastin isoform 1	374	Sufficient for microtubule severing.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CTTAGAGCTCCTGCCAGAGGG	0.383													12	40					0	0	0.00185496	0	0
SIX3	6496	broad.mit.edu	37	2	45171798	45171798	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:45171798G>A	uc002run.1	+	2	1105	c.898G>A	c.(898-900)GCG>ACG	p.A300T		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	300					visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GCCGTCCACGGCGGCCAGCCC	0.701													3	2					0	0	6.4e-05	0	0
APLF	200558	broad.mit.edu	37	2	68753283	68753283	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:68753283C>T	uc002sep.2	+	6	886	c.713C>T	c.(712-714)TCA>TTA	p.S238L	APLF_uc010fdf.2_Missense_Mutation_p.S214L	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	238					double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						CAATTAATTTCATCAGGAAGT	0.378													8	64					0	0	0.000442599	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746778	77746778	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:77746778T>C	uc002snr.2	-	3	632	c.217A>G	c.(217-219)ATT>GTT	p.I73V	LRRTM4_uc002snq.2_Missense_Mutation_p.I73V|LRRTM4_uc002sns.2_Missense_Mutation_p.I73V|LRRTM4_uc002snt.2_Missense_Mutation_p.I74V	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	73	LRR 1.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		AGCTTCTGAATGCTGTTGAAC	0.408													14	45					0	0	0.000422831	0	0
MAT2A	4144	broad.mit.edu	37	2	85770138	85770138	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:85770138C>T	uc002spr.2	+	8	1189	c.1066C>T	c.(1066-1068)CGC>TGC	p.R356C	MAT2A_uc010ysr.1_Missense_Mutation_p.R356C|MAT2A_uc010fgk.2_Missense_Mutation_p.R330C|MAT2A_uc010fgl.2_Missense_Mutation_p.R293C	NM_005911	NP_005902	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	356					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TTTCGATCTCCGCCCTGGGGT	0.428													35	50					0	0	0.000814825	0	0
KCNIP3	30818	broad.mit.edu	37	2	95963201	95963201	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:95963201G>A	uc002sup.2	+	1	130	c.15G>A	c.(13-15)AAG>AAA	p.K5K	KCNIP3_uc002sun.1_RNA|KCNIP3_uc002suo.1_Silent_p.K5K	NM_013434	NP_038462	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3 isoform 1	5					apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			breast(2)|ovary(1)	3				READ - Rectum adenocarcinoma(193;0.13)		AGCCGGCTAAGGTAGGTGCTG	0.627													3	6					0	0	0.00024832	0	0
TMEM131	23505	broad.mit.edu	37	2	98382998	98382998	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:98382998G>A	uc002syh.3	-	34	4745	c.4516C>T	c.(4516-4518)CCT>TCT	p.P1506S		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1506						integral to membrane				ovary(4)|central_nervous_system(2)	6						GTTGGAAGAGGAATCTTGCTT	0.383													32	97					0	0	0.0024448	0	0
CNGA3	1261	broad.mit.edu	37	2	99012839	99012839	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:99012839G>A	uc002syt.2	+	8	1623	c.1206G>A	c.(1204-1206)ATG>ATA	p.M402I	CNGA3_uc002syu.2_Missense_Mutation_p.M384I|CNGA3_uc010fij.2_Missense_Mutation_p.M406I	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	402					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						TGGGCTCCATGATCTCGAATA	0.517													30	54					0	0	0.00178596	0	0
SLC9A2	6549	broad.mit.edu	37	2	103274316	103274316	+	Missense_Mutation	SNP	G	A	A	rs61743555	byFrequency	TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:103274316G>A	uc002tca.2	+	2	725	c.583G>A	c.(583-585)GAA>AAA	p.E195K		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	195	Extracellular (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						CTGCCAGATCGAAGCATTCGG	0.478													71	157					0	0	0.000781405	0	0
SULT1C2	6819	broad.mit.edu	37	2	108917356	108917356	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:108917356C>T	uc002tdy.2	+	4	793	c.340C>T	c.(340-342)CTG>TTG	p.L114L	SULT1C2_uc010ywp.1_Silent_p.L29L|SULT1C2_uc002tdx.2_Silent_p.L125L|SULT1C2_uc010ywq.1_Silent_p.L128L	NM_001056	NP_001047	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 1	114					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			ovary(1)	1						TTCCACTCAGCTGCTGCCACC	0.478													44	98					0	0	0.000781405	0	0
LOC440905	440905	broad.mit.edu	37	2	130792768	130792768	+	RNA	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:130792768G>A	uc002tpz.2	-	8		c.2561C>T				NR_026758				Homo sapiens cDNA FLJ43933 fis, clone TESTI4013685.												0						TGTATCACCTGGAATTGGAAT	0.463													4	23					0	0	0.00024832	0	0
POTEE	445582	broad.mit.edu	37	2	132021568	132021568	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:132021568G>A	uc002tsn.2	+	15	2592	c.2540G>A	c.(2539-2541)CGT>CAT	p.R847H	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Missense_Mutation_p.R447H|POTEE_uc002tsl.2_Missense_Mutation_p.R429H|POTEE_uc010fmy.1_Missense_Mutation_p.R311H	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	847	Actin-like.						ATP binding				0						ACCTCTGGCCGTACTACTGGC	0.607													22	141					0	0	0.00047179	0	0
YSK4	80122	broad.mit.edu	37	2	135745354	135745354	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:135745354T>C	uc002tue.1	-	7	1119	c.1088A>G	c.(1087-1089)AAC>AGC	p.N363S	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.N250S|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.N91S|YSK4_uc002tui.3_Missense_Mutation_p.N380S	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	363							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		ATATTGAGAGTTCTCTTCTTC	0.378													27	58					0	0	0.000720815	0	0
THSD7B	80731	broad.mit.edu	37	2	138421075	138421075	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:138421075G>A	uc002tva.1	+	25	4494	c.4494G>A	c.(4492-4494)GGG>GGA	p.G1498G	THSD7B_uc010zbj.1_RNA	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		ACCTTTCTGGGAAAAACAGAC	0.363													3	12					0	0	6.4e-05	0	0
SCN7A	6332	broad.mit.edu	37	2	167273342	167273342	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:167273342G>A	uc002udu.1	-	20	3416	c.3289C>T	c.(3289-3291)CCT>TCT	p.P1097S	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1097					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TCAGATGAAGGAAACCTTTCT	0.388													11	19					0	0	0.000978159	0	0
TTN	7273	broad.mit.edu	37	2	179437859	179437859	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:179437859C>T	uc010zfg.1	-	275	65520	c.65296G>A	c.(65296-65298)GAT>AAT	p.D21766N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D15461N|TTN_uc010zfi.1_Missense_Mutation_p.D15394N|TTN_uc010zfj.1_Missense_Mutation_p.D15269N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22693							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCTTGTATCCAGAACACGT	0.448													13	40					0	0	0.00185496	0	0
TTN	7273	broad.mit.edu	37	2	179438868	179438868	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:179438868G>A	uc010zfg.1	-	275	64511	c.64287C>T	c.(64285-64287)TTC>TTT	p.F21429F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.F15124F|TTN_uc010zfi.1_Silent_p.F15057F|TTN_uc010zfj.1_Silent_p.F14932F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22356							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGATCACACGGAATTCATATG	0.473													20	63					0	0	0.00188189	0	0
TTN	7273	broad.mit.edu	37	2	179452496	179452496	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:179452496C>T	uc010zfg.1	-	255	56060	c.55836G>A	c.(55834-55836)ATG>ATA	p.M18612I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.M12307I|TTN_uc010zfi.1_Missense_Mutation_p.M12240I|TTN_uc010zfj.1_Missense_Mutation_p.M12115I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19539							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAGTTTCCTCATGCTGGCAT	0.428													14	24					0	0	0.000566183	0	0
TTN	7273	broad.mit.edu	37	2	179495596	179495596	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:179495596C>T	uc010zfg.1	-	187	36609	c.36385G>A	c.(36385-36387)GAA>AAA	p.E12129K	TTN_uc010zfh.1_Missense_Mutation_p.E5824K|TTN_uc010zfi.1_Missense_Mutation_p.E5757K|TTN_uc010zfj.1_Missense_Mutation_p.E5632K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13056							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGAGATTTCGGTTTCAAAG	0.493													23	89					0	0	0.00047179	0	0
TTN	7273	broad.mit.edu	37	2	179604664	179604664	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:179604664G>A	uc010zfh.1	-	46	13007	c.12783C>T	c.(12781-12783)ATC>ATT	p.I4261I	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Silent_p.I4194I|TTN_uc010zfj.1_Silent_p.I4069I|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTCTTGGGTGATGTTTACAG	0.473													30	83					0	0	0.001512	0	0
TTN	7273	broad.mit.edu	37	2	179610653	179610653	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:179610653C>T	uc002unb.2	-	46	16698	c.16474G>A	c.(16474-16476)GAA>AAA	p.E5492K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCAATTCTTCCATTAAACTG	0.408													26	38					0	0	0.00047179	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801921	185801921	+	Nonsense_Mutation	SNP	A	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:185801921A>T	uc002uph.2	+	4	2392	c.1798A>T	c.(1798-1800)AAA>TAA	p.K600*		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	600						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAAAAAAAGAAAAAAGTTATG	0.328													52	89					0	0	0.000781405	0	0
DNAH7	56171	broad.mit.edu	37	2	196801382	196801382	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:196801382G>A	uc002utj.3	-	20	3314	c.3213C>T	c.(3211-3213)TTC>TTT	p.F1071F		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1071	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ACAAAAAAAAGAATCTGGGGA	0.328													29	64					0	0	0.00178596	0	0
HECW2	57520	broad.mit.edu	37	2	197090520	197090520	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:197090520G>A	uc002utm.1	-	23	4175	c.3992C>T	c.(3991-3993)CCC>CTC	p.P1331L	HECW2_uc002utl.1_Missense_Mutation_p.P975L	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1331	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CTTATAAAAGGGCCGTGTGAA	0.373													13	53					0	0	0.000566183	0	0
HSPE1	3336	broad.mit.edu	37	2	198365916	198365916	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:198365916T>C	uc002uul.2	+	2	562	c.122T>C	c.(121-123)GTA>GCA	p.V41A	HSPD1_uc002uui.2_5'Flank|HSPD1_uc002uuj.2_5'Flank|HSPD1_uc010zgx.1_5'Flank|HSPD1_uc010fsm.2_5'Flank|HSPD1_uc002uuk.2_5'Flank|HSPD1_uc010zgy.1_5'Flank	NM_002157	NP_002148	P61604	CH10_HUMAN	heat shock 10kDa protein 1	41					activation of caspase activity|protein folding|response to unfolded protein	mitochondrial matrix	ATP binding|chaperone binding|unfolded protein binding				0			Epithelial(96;0.225)			CAAGGAAAAGTATTGCAAGCA	0.423													11	24					0	0	0.000673444	0	0
PLCL1	5334	broad.mit.edu	37	2	198949322	198949322	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:198949322G>A	uc010fsp.2	+	2	1372	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K	PLCL1_uc002uuv.3_Missense_Mutation_p.E282K	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	361					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AAGGAGATACGAACTTTCTGA	0.388													20	53					0	0	0.00121646	0	0
CXCR2P1	3580	broad.mit.edu	37	2	218925402	218925402	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:218925402C>T	uc002vgx.2	-	1	612	c.319G>A	c.(319-321)GGA>AGA	p.G107R	RUFY4_uc002vgw.2_Intron	NR_002712				Homo sapiens interleukin 8 receptor, beta pseudogene, mRNA (cDNA clone IMAGE:5450999), with apparent retained intron.												0						CCACATGGTCCAGTGCTTCTG	0.557													9	48					0	0	0.000978159	0	0
CXCR2	3579	broad.mit.edu	37	2	219000488	219000488	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:219000488C>T	uc002vgz.1	+	4	1189	c.964C>T	c.(964-966)CGC>TGC	p.R322C	CXCR2_uc002vha.1_Missense_Mutation_p.R322C|CXCR2_uc002vhb.1_Missense_Mutation_p.R322C	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	322	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						CCAGAAGTTTCGCCATGGACT	0.547													43	74					0	0	0.000781405	0	0
SPEG	10290	broad.mit.edu	37	2	220338231	220338231	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:220338231A>G	uc010fwg.2	+	17	4153	c.4153A>G	c.(4153-4155)ACC>GCC	p.T1385A		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1385	Ig-like 7.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCCAGGCCCAACCCTGGAGGA	0.363													35	56					0	0	0.0024448	0	0
SPEG	10290	broad.mit.edu	37	2	220356966	220356966	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:220356966C>T	uc010fwg.2	+	40	9595	c.9595C>T	c.(9595-9597)CTC>TTC	p.L3199F		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	3199	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCGAAAGGTTCTCTCTGTACA	0.617													16	40					0	0	0.000566183	0	0
PID1	55022	broad.mit.edu	37	2	229890441	229890441	+	Silent	SNP	C	T	T	rs140609082		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:229890441C>T	uc002vpr.3	-	3	698	c.660G>A	c.(658-660)AGG>AGA	p.R220R	PID1_uc002vps.3_Silent_p.R218R|PID1_uc002vpt.3_Silent_p.R187R|PID1_uc002vpu.3_Silent_p.R138R	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	220	PID.					cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GGAAAGTCTTCCTGAAGGCCT	0.552													43	66					0	0	0.0025221	0	0
HTR2B	3357	broad.mit.edu	37	2	231973942	231973942	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:231973942C>T	uc002vro.2	-	4	1240	c.735G>A	c.(733-735)CAG>CAA	p.Q245Q	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Silent_p.Q178Q	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	245	Cytoplasmic (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	AAGCCTTCTTCTGTAAAGCAT	0.448													24	60					0	0	0.00229938	0	0
AGAP1	116987	broad.mit.edu	37	2	236708045	236708045	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:236708045C>T	uc002vvs.2	+	8	1431	c.836C>T	c.(835-837)TCC>TTC	p.S279F	AGAP1_uc002vvt.2_Missense_Mutation_p.S279F	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	279					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						AGCGACTATTCCTCCTCCGTT	0.507													13	44					0	0	0.00136819	0	0
MAVS	57506	broad.mit.edu	37	20	3844945	3844945	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr20:3844945C>T	uc002wjw.3	+	6	837	c.668C>T	c.(667-669)CCA>CTA	p.P223L	MAVS_uc002wjx.3_Missense_Mutation_p.P82L|MAVS_uc002wjy.3_5'UTR	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	223	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						CCTGTGTCTCCATCTGTCTCC	0.602													37	101					0	0	0.0025221	0	0
CHGB	1114	broad.mit.edu	37	20	5903238	5903238	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr20:5903238G>A	uc002wmg.2	+	4	754	c.448G>A	c.(448-450)GAA>AAA	p.E150K	CHGB_uc010zqz.1_5'UTR	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	150						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						CCAAGTCTCTGAAGAAGTGAA	0.572													7	18					0	0	0.00198382	0	0
BMP2	650	broad.mit.edu	37	20	6759224	6759224	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr20:6759224G>A	uc002wmu.1	+	3	1464	c.679G>A	c.(679-681)GTG>ATG	p.V227M		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	227					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	CCATGGATTCGTGGTGGAAGT	0.522													6	21					0	0	0.00116845	0	0
MACROD2	140733	broad.mit.edu	37	20	15412057	15412057	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr20:15412057C>T	uc002wou.2	+	7	812	c.548C>T	c.(547-549)CCC>CTC	p.P183L	MACROD2_uc002wot.2_Missense_Mutation_p.P183L|MACROD2_uc002woz.2_5'UTR	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1	183	Macro.										0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				CAGGCATTTCCCTGCATCTCA	0.313													23	73					0	0	0.00178596	0	0
ERGIC3	51614	broad.mit.edu	37	20	34144766	34144766	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr20:34144766C>T	uc002xct.2	+	11	971	c.902C>T	c.(901-903)TCT>TTT	p.S301F	ERGIC3_uc002xcs.2_Missense_Mutation_p.S306F|ERGIC3_uc002xcu.2_Missense_Mutation_p.S316F|ERGIC3_uc002xcv.2_Missense_Mutation_p.S264F	NM_015966	NP_057050	Q9Y282	ERGI3_HUMAN	serologically defined breast cancer antigen 84	301	Lumenal (Potential).				vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane	protein binding			large_intestine(2)|ovary(1)	3	Lung NSC(9;0.00489)|all_lung(11;0.00729)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			AATCAGTTCTCTGTGACCAGA	0.612													15	22					0	0	0.000958276	0	0
ZMYND8	23613	broad.mit.edu	37	20	45867837	45867838	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr20:45867837_45867838GG>AA	uc002xta.1	-	15	2523_2524	c.2269_2270CC>TT	c.(2269-2271)CCC>TTC	p.P757F	ZMYND8_uc010ghq.1_Missense_Mutation_p.P434F|ZMYND8_uc010ghr.1_Missense_Mutation_p.P732F|ZMYND8_uc002xst.1_Missense_Mutation_p.P685F|ZMYND8_uc002xsu.1_Intron|ZMYND8_uc002xsv.1_Missense_Mutation_p.P685F|ZMYND8_uc002xsw.1_Missense_Mutation_p.P509F|ZMYND8_uc002xsx.1_Missense_Mutation_p.P509F|ZMYND8_uc002xsy.1_Missense_Mutation_p.P732F|ZMYND8_uc002xsz.1_Missense_Mutation_p.P694F|ZMYND8_uc010zxy.1_Missense_Mutation_p.P784F|ZMYND8_uc002xtb.1_Missense_Mutation_p.P777F|ZMYND8_uc002xss.2_Missense_Mutation_p.P757F|ZMYND8_uc010zxz.1_Intron|ZMYND8_uc002xtc.1_Missense_Mutation_p.P777F|ZMYND8_uc002xtd.1_Missense_Mutation_p.P752F|ZMYND8_uc002xte.1_Missense_Mutation_p.P757F|ZMYND8_uc010zya.1_Missense_Mutation_p.P757F|ZMYND8_uc002xtf.1_Missense_Mutation_p.P777F|ZMYND8_uc002xtg.2_Missense_Mutation_p.P751F|ZMYND8_uc010ghs.1_Missense_Mutation_p.P751F|ZMYND8_uc002xsr.1_5'UTR	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	757							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TGTTTCCGGGGGAGAATGGCTG	0.584													33	90					0	0	6.4e-05	0	0
ZNFX1	57169	broad.mit.edu	37	20	47869279	47869280	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr20:47869279_47869280GG>AA	uc002xui.2	-	12	3440_3441	c.3193_3194CC>TT	c.(3193-3195)CCC>TTC	p.P1065F		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1065							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ACGGACAAAGGGAATGTTTACT	0.505													37	103					0	0	6.4e-05	0	0
C20orf177	63939	broad.mit.edu	37	20	58519738	58519738	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr20:58519738C>T	uc002yba.2	+	5	1155	c.740C>T	c.(739-741)TCC>TTC	p.S247F	C20orf177_uc010zzx.1_Missense_Mutation_p.S90F|C20orf177_uc002ybc.2_Missense_Mutation_p.S247F	NM_022106	NP_071389	Q9NTX9	CT177_HUMAN	hypothetical protein LOC63939	247										ovary(2)|breast(1)	3	all_lung(29;0.00693)		BRCA - Breast invasive adenocarcinoma(7;1.22e-08)			TCAGGCCCTTCCCGAAAGAAA	0.493													37	84					0	0	0.000953801	0	0
KCNQ2	3785	broad.mit.edu	37	20	62076679	62076679	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr20:62076679G>A	uc002yey.1	-	3	603	c.426C>T	c.(424-426)TTC>TTT	p.F142F	KCNQ2_uc002yez.1_Silent_p.F142F|KCNQ2_uc002yfa.1_Silent_p.F142F|KCNQ2_uc002yfb.1_Silent_p.F142F|KCNQ2_uc011aax.1_Silent_p.F142F|KCNQ2_uc002yfc.1_Silent_p.F142F	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	142	Helical; Name=Segment S2; (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	AGATCCGCACGAAGTACTCCA	0.647													18	30					0	0	0.00074312	0	0
OPRL1	4987	broad.mit.edu	37	20	62730145	62730145	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr20:62730145C>T	uc002yic.2	+	5	1508	c.1106C>T	c.(1105-1107)CCC>CTC	p.P369L	OPRL1_uc002yid.2_Missense_Mutation_p.P369L|OPRL1_uc002yif.3_Missense_Mutation_p.P364L	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	369	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GTACCGCGGCCCGCATGACTA	0.662													9	21					0	0	0.000978159	0	0
TPTE	7179	broad.mit.edu	37	21	10934106	10934106	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr21:10934106C>T	uc002yip.1	-	16	1239	c.871G>A	c.(871-873)GAT>AAT	p.D291N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.D273N|TPTE_uc002yir.1_Missense_Mutation_p.D253N|TPTE_uc010gkv.1_Missense_Mutation_p.D153N	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	291	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.V291I(1)		ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGCTTAGGATCGTAAGCTCTT	0.308													24	221					0	0	0.000586117	0	0
USP25	29761	broad.mit.edu	37	21	17163931	17163931	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr21:17163931C>T	uc002yjy.1	+	5	720	c.503C>T	c.(502-504)CCC>CTC	p.P168L	USP25_uc011aby.1_Missense_Mutation_p.P168L|USP25_uc002yjz.1_Missense_Mutation_p.P168L|USP25_uc010gla.1_Missense_Mutation_p.P168L	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	168					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		GACAAAGCTCCCGTTGGGCTA	0.393													27	43					0	0	0.000878237	0	0
IL10RB	3588	broad.mit.edu	37	21	34655546	34655546	+	Missense_Mutation	SNP	G	A	A	rs45469692		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr21:34655546G>A	uc002yrk.1	+	5	745	c.646G>A	c.(646-648)GAA>AAA	p.E216K	IL10RB_uc002yrh.1_3'UTR|IL10RB_uc002yri.1_3'UTR|IL10RB_uc002yrl.1_Missense_Mutation_p.E218K	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	216	Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						AACCCATGACGGTAAGCCCTG	0.418													22	55					0	0	0.00188189	0	0
DSCAM	1826	broad.mit.edu	37	21	41465752	41465752	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr21:41465752G>A	uc002yyq.1	-	21	4198	c.3746C>T	c.(3745-3747)CCC>CTC	p.P1249L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1249	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ACTCAGGTTGGGAATTCTGTA	0.488													17	30					0	0	0.000566183	0	0
DNMT3L	29947	broad.mit.edu	37	21	45678547	45678547	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr21:45678547C>T	uc002zeg.1	-	6	859	c.375G>A	c.(373-375)CTG>CTA	p.L125L	DNMT3L_uc002zeh.1_Silent_p.L125L	NM_175867	NP_787063	Q9UJW3	DNM3L_HUMAN	cytosine-5-methyltransferase 3-like protein	125	PHD-type; atypical.|ADD.				DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			skin(2)	2				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		CGGGGCCGACCAGGCTATCCA	0.637													12	34					0	0	0.00185496	0	0
CECR6	27439	broad.mit.edu	37	22	17600384	17600384	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr22:17600384G>A	uc002zmb.2	-	1	1830	c.1634C>T	c.(1633-1635)CCG>CTG	p.P545L	CECR6_uc002zma.2_Missense_Mutation_p.P190L|uc002zmc.2_5'Flank	NM_031890	NP_114096	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	545	Poly-Pro.										0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		AGGTGGTGGCGGAGGTGGTGG	0.697													4	8					0	0	0.00024832	0	0
P2RX6	9127	broad.mit.edu	37	22	21377588	21377588	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr22:21377588C>T	uc010gsu.1	+	7	663	c.663C>T	c.(661-663)GAC>GAT	p.D221D	P2RX6_uc002ztz.2_Silent_p.D195D|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	221	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						AGACCTGGGACCCCACCTATT	0.582													50	120					0	0	0.000781405	0	0
MYO18B	84700	broad.mit.edu	37	22	26165193	26165193	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr22:26165193G>A	uc003abz.1	+	4	1560	c.1310G>A	c.(1309-1311)TGG>TAG	p.W437*	MYO18B_uc003aca.1_Nonsense_Mutation_p.W318*|MYO18B_uc010guy.1_Nonsense_Mutation_p.W318*|MYO18B_uc010guz.1_Nonsense_Mutation_p.W318*|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	437						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AAGGGAGGCTGGCCAGGAAGC	0.632													4	12					0	0	0.000602214	0	0
SF3A1	10291	broad.mit.edu	37	22	30735185	30735185	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr22:30735185G>A	uc003ahl.2	-	10	1563	c.1431C>T	c.(1429-1431)TTC>TTT	p.F477F		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	477					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						CCTCTACACCGAAGATGTCAG	0.488													49	105					0	0	0.000781405	0	0
FBLN1	2192	broad.mit.edu	37	22	45970515	45970515	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr22:45970515G>A	uc003bgj.1	+	15	1969	c.1822G>A	c.(1822-1824)GAG>AAG	p.E608K		NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	608					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TACCTTCCGCGAGTTCACCCG	0.647													19	17					0	0	0.00188189	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50660294	50660294	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr22:50660294G>A	uc003bkb.1	-	16	3006	c.2494C>T	c.(2494-2496)CCG>TCG	p.P832S	TUBGCP6_uc003bka.1_5'UTR|TUBGCP6_uc010har.1_Missense_Mutation_p.P824S|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_Missense_Mutation_p.P28S	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	832					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCAGGGCCCGGAGACGTGACC	0.622													7	27					0	0	0.000157383	0	0
PPARG	5468	broad.mit.edu	37	3	12421374	12421374	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:12421374G>A	uc003bwx.2	+	2	345	c.254G>A	c.(253-255)AGA>AAA	p.R85K	PPARG_uc003bwr.2_Missense_Mutation_p.R57K|PPARG_uc003bws.2_Missense_Mutation_p.R57K|PPARG_uc003bwu.2_Missense_Mutation_p.R57K|PPARG_uc003bwv.2_Missense_Mutation_p.R57K|PPARG_uc010hea.1_RNA|PPARG_uc003bwq.1_Missense_Mutation_p.R57K|PPARG_uc010hdz.1_RNA|PPARG_uc003bwt.1_Missense_Mutation_p.R57K|PPARG_uc003bww.1_Missense_Mutation_p.R85K	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	85					activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	CCATTCACAAGAACAGATCCA	0.393			T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						179	182					0	0	0.000781405	0	0
TMEM43	79188	broad.mit.edu	37	3	14174406	14174406	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:14174406C>T	uc003byk.2	+	6	737	c.483C>T	c.(481-483)TTC>TTT	p.F161F	TMEM43_uc003byl.1_Silent_p.F41F	NM_024334	NP_077310	Q9BTV4	TMM43_HUMAN	transmembrane protein 43	161	Lumenal (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|nuclear inner membrane				ovary(1)	1						GCAAAAACTTCGACCGAGAGA	0.498													17	14					0	0	0.000566183	0	0
TRIM71	131405	broad.mit.edu	37	3	32859584	32859584	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:32859584C>T	uc003cff.2	+	1	75	c.12C>T	c.(10-12)TTC>TTT	p.F4F		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	4					multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						TGGCTTCGTTCCCCGAGACCG	0.572													13	14					0	0	0.00185496	0	0
LTF	4057	broad.mit.edu	37	3	46485063	46485063	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:46485063G>A	uc003cpq.2	-	13	1562	c.1524C>T	c.(1522-1524)TTC>TTT	p.F508F	LTF_uc003fzr.2_Silent_p.F464F|LTF_uc010hjh.2_Silent_p.F506F|LTF_uc003cpr.2_Silent_p.F495F	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	508	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	AGCTTTGACTGAAATATTCAT	0.517													52	70					0	0	0.000781405	0	0
MYL3	4634	broad.mit.edu	37	3	46904827	46904827	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:46904827C>T	uc003cql.1	-	1	147	c.54G>A	c.(52-54)AAG>AAA	p.K18K		NM_000258	NP_000249	P08590	MYL3_HUMAN	slow skeletal ventricular myosin alkali light	18					cardiac muscle contraction|muscle filament sliding|positive regulation of ATPase activity|regulation of striated muscle contraction|regulation of the force of heart contraction|ventricular cardiac muscle tissue morphogenesis	A band|cytosol|I band|muscle myosin complex	actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle				0				BRCA - Breast invasive adenocarcinoma(193;0.00116)|KIRC - Kidney renal clear cell carcinoma(197;0.00557)|Kidney(197;0.0063)		CTGGAGCTGCCTTGGGGGCTG	0.582													29	22					0	0	0.000878237	0	0
SETD2	29072	broad.mit.edu	37	3	47162509	47162509	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:47162509G>A	uc003cqs.2	-	3	3670	c.3617C>T	c.(3616-3618)TCT>TTT	p.S1206F	SETD2_uc003cqv.2_Missense_Mutation_p.S1195F	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AAAATCAGAAGAATAAATTGG	0.418			N|F|S|Mis		clear cell renal carcinoma								36	45					0	0	0.00058488	0	0
STAB1	23166	broad.mit.edu	37	3	52554934	52554934	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:52554934G>A	uc003dej.2	+	55	5895	c.5821G>A	c.(5821-5823)GGC>AGC	p.G1941S	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1941	Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TAGGCCCCAAGGCCTGGGCAG	0.632													38	26					0	0	0.000692331	0	0
FOXP1	27086	broad.mit.edu	37	3	71247393	71247393	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:71247393C>T	uc003dol.2	-	2	463	c.140G>A	c.(139-141)GGG>GAG	p.G47E	FOXP1_uc003dom.2_Missense_Mutation_p.G47E|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Missense_Mutation_p.G47E|FOXP1_uc003dop.2_Missense_Mutation_p.G47E|FOXP1_uc003doq.1_Missense_Mutation_p.G47E|FOXP1_uc003dos.2_Missense_Mutation_p.G47E	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	47					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GTCAGCTGCCCCGATGTCCAC	0.627			T	PAX5	ALL								41	178					0	0	0.00148497	0	0
ALCAM	214	broad.mit.edu	37	3	105266104	105266104	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:105266104G>A	uc003dvx.2	+	10	1756	c.1216G>A	c.(1216-1218)GAG>AAG	p.E406K	ALCAM_uc003dvw.1_Missense_Mutation_p.E406K|ALCAM_uc003dvy.2_Missense_Mutation_p.E406K|ALCAM_uc010hpp.2_Missense_Mutation_p.E128K|ALCAM_uc003dvz.2_Missense_Mutation_p.E40K	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	406	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						AAAGAAAAGAGAGTCATTGAC	0.378													22	24					0	0	0.00188189	0	0
KIAA2018	205717	broad.mit.edu	37	3	113374606	113374606	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:113374606G>A	uc003eam.2	-	7	6334	c.5923C>T	c.(5923-5925)CCC>TCC	p.P1975S	KIAA2018_uc003eal.2_Missense_Mutation_p.P1919S	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1975					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GATCTCTGGGGAACTGAAGAA	0.498													15	30					0	0	0.00244969	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377038	113377038	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:113377038G>A	uc003eam.2	-	7	3902	c.3491C>T	c.(3490-3492)CCT>CTT	p.P1164L	KIAA2018_uc003eal.2_Missense_Mutation_p.P1108L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1164					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TGCTTCAGAAGGCTTTGAAGC	0.453													25	56					0	0	0.000586117	0	0
SLC15A2	6565	broad.mit.edu	37	3	121641931	121641931	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:121641931C>T	uc003eep.2	+	10	1065	c.912C>T	c.(910-912)TTC>TTT	p.F304F	SLC15A2_uc011bjn.1_Silent_p.F273F	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	304	Helical; (Potential).				protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GGGTACTATTCCTTTATATCC	0.453													57	135					0	0	0.000781405	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125877271	125877271	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:125877271G>A	uc003eim.1	-	3	529	c.339C>T	c.(337-339)CAC>CAT	p.H113H	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Silent_p.H113H|ALDH1L1_uc003eio.2_5'Flank|ALDH1L1_uc010hsf.1_Silent_p.H139H|ALDH1L1_uc003eip.1_Silent_p.H22H|ALDH1L1_uc011bkj.1_Intron	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	113	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	AGGCCCCTCGGTGCCTAGGGA	0.572													3	10					0	0	6.4e-05	0	0
CP	1356	broad.mit.edu	37	3	148928058	148928058	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:148928058C>G	uc003ewy.3	-	3	756	c.503G>C	c.(502-504)GGG>GCG	p.G168A	CP_uc011bnr.1_RNA|CP_uc003ewx.3_5'Flank|CP_uc003ewz.2_Missense_Mutation_p.G168A|CP_uc010hvf.1_5'Flank	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	168	F5/8 type A 1.|Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	ATCTCCTTCCCCAGGACTTTG	0.413													22	90					0	0	0.00152264	0	0
PRKCI	5584	broad.mit.edu	37	3	169999014	169999014	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:169999014C>T	uc003fgs.2	+	10	1181	c.943C>T	c.(943-945)CTT>TTT	p.L315F		NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	315	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TCATCCTTTCCTTGTTGGGCT	0.363													27	38					0	0	0.000878237	0	0
KLHL6	89857	broad.mit.edu	37	3	183209742	183209742	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:183209742C>T	uc003flr.2	-	7	1897	c.1839G>A	c.(1837-1839)AGG>AGA	p.R613R	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_3'UTR|KLHL6_uc010hxk.1_RNA	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	613										haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			CGGGCACGATCCTGCGGATGT	0.672													25	42					0	0	0.000720815	0	0
FGF12	2257	broad.mit.edu	37	3	192053236	192053236	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:192053236G>A	uc003fsx.2	-	3	1154	c.328C>T	c.(328-330)CCC>TCC	p.P110S	FGF12_uc003fsy.2_Missense_Mutation_p.P48S	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	110					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		AGGCCCACGGGAATTAGATTG	0.433													8	38					0	0	0.000157383	0	0
ATP13A5	344905	broad.mit.edu	37	3	193019021	193019021	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr3:193019021G>A	uc011bsq.1	-	24	2754	c.2754C>T	c.(2752-2754)ATC>ATT	p.I918I		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	918	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		GTAATGCACTGATAAACTGGA	0.343													41	53					0	0	0.00285205	0	0
KIAA1530	57654	broad.mit.edu	37	4	1347001	1347001	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:1347001C>T	uc003gde.3	+	5	1181	c.734C>T	c.(733-735)CCC>CTC	p.P245L		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	245											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			ACCCCTGACCCCCGGGACGGG	0.711													9	9					0	0	0.000442599	0	0
C4orf23	152992	broad.mit.edu	37	4	8467171	8467171	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:8467171C>T	uc003glg.1	+	8	878	c.690C>T	c.(688-690)TCC>TCT	p.S230S	C4orf23_uc003glf.1_Silent_p.S218S|C4orf23_uc003glh.1_Silent_p.S67S	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	459					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						GAAGATACTCCCGGAGGCAGA	0.488													33	31					0	0	0.00209593	0	0
KCNIP4	80333	broad.mit.edu	37	4	21305511	21305511	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:21305511C>T	uc003gqf.1	-	1	19	c.19G>A	c.(19-21)GAA>AAA	p.E7K	KCNIP4_uc003gqg.1_Intron|KCNIP4_uc003gqh.1_Intron|KCNIP4_uc003gqi.1_Intron	NM_147183	NP_671712	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4 isoform 4	Error:Variant_position_missing_in_Q6PIL6_after_alignment						plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)				GCTATCATTTCAAGCCCTTCC	0.433													24	16					0	0	0.000720815	0	0
LGI2	55203	broad.mit.edu	37	4	25013958	25013958	+	Silent	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:25013958T>C	uc003grf.2	-	7	918	c.819A>G	c.(817-819)ACA>ACG	p.T273T		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	273	EAR 2.					extracellular region					0		Breast(46;0.173)				ACAACACACCTGTAATGTTGT	0.522													3	94					0	0	0.00024832	0	0
KDR	3791	broad.mit.edu	37	4	55956161	55956161	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:55956161C>T	uc003has.2	-	23	3456	c.3154G>A	c.(3154-3156)GAT>AAT	p.D1052N	KDR_uc003hat.1_Missense_Mutation_p.D1052N	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1052	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TTATAAATATCCCGGGCCAAG	0.408			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			27	59					0	0	0.00106085	0	0
EPHA5	2044	broad.mit.edu	37	4	66280049	66280049	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:66280049C>T	uc003hcy.2	-	7	1833	c.1640G>A	c.(1639-1641)GGC>GAC	p.G547D	EPHA5_uc003hcx.2_Missense_Mutation_p.G478D|EPHA5_uc003hcz.2_Missense_Mutation_p.G547D|EPHA5_uc011cah.1_Missense_Mutation_p.G547D|EPHA5_uc011cai.1_Missense_Mutation_p.G547D|EPHA5_uc003hda.2_Missense_Mutation_p.G547D	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	547	Extracellular (Potential).|Fibronectin type-III 2.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GACACCATAGCCTGCTGCTGT	0.408										TSP Lung(17;0.13)			28	54					0	0	0.00127121	0	0
AFP	174	broad.mit.edu	37	4	74309109	74309109	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:74309109C>T	uc003hgz.1	+	6	708	c.661C>T	c.(661-663)CAA>TAA	p.Q221*	AFP_uc003hha.1_Nonsense_Mutation_p.Q221*|AFP_uc011cbg.1_5'UTR	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	221	Albumin 2.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTTGTTAAATCAACATGCATG	0.368									Alpha-Fetoprotein_Hereditary_Persistence_of				15	50					0	0	0.000566183	0	0
CCDC158	339965	broad.mit.edu	37	4	77288469	77288469	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:77288469C>T	uc003hkb.3	-	11	1961	c.1808G>A	c.(1807-1809)CGG>CAG	p.R603Q		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	603	Potential.									skin(3)|ovary(2)|pancreas(1)	6						TAGTTCCATCCGCCTATCATT	0.398													29	80					0	0	0.0024448	0	0
NUDT9	53343	broad.mit.edu	37	4	88356186	88356186	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:88356186C>T	uc003hqq.2	+	2	484	c.161C>T	c.(160-162)TCT>TTT	p.S54F	NUDT9_uc003hqr.2_Missense_Mutation_p.S4F|NUDT9_uc010ikl.2_Missense_Mutation_p.S54F	NM_024047	NP_076952	Q9BW91	NUDT9_HUMAN	nudix-type motif 9 isoform a	54						mitochondrion	ADP-ribose diphosphatase activity				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000937)		ATGTCTGGTTCTAATGGTTCC	0.383													12	35					0	0	0.000978159	0	0
DKK2	27123	broad.mit.edu	37	4	107846995	107846995	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:107846995G>A	uc003hyi.2	-	2	1039	c.334C>T	c.(334-336)CGA>TGA	p.R112*	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Nonsense_Mutation_p.R112*	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	112	DKK-type Cys-1.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space		p.R112G(1)		ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		ATGCCATCTCGGTGGCAGCGC	0.493													46	67					0	0	0.000781405	0	0
KIAA1109	84162	broad.mit.edu	37	4	123161105	123161105	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:123161105C>A	uc003ieh.2	+	27	4313	c.4268C>A	c.(4267-4269)ACC>AAC	p.T1423N	KIAA1109_uc003iei.1_Missense_Mutation_p.T1176N|KIAA1109_uc010ins.1_Missense_Mutation_p.T766N|KIAA1109_uc003iek.2_Missense_Mutation_p.T42N	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1423					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AAAAAGCAAACCCAGCAGATT	0.453													15	19					0.000422831	0.00154708	0.000422831	1	0
VEGFC	7424	broad.mit.edu	37	4	177650814	177650814	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr4:177650814C>T	uc003ius.1	-	2	664	c.234G>A	c.(232-234)TGG>TGA	p.W78*		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	78					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		TGTACATTTTCCAATATTCTG	0.433													11	10					0	0	0.000978159	0	0
ADCY2	108	broad.mit.edu	37	5	7414758	7414758	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:7414758C>T	uc003jdz.1	+	2	350	c.283C>T	c.(283-285)CTG>TTG	p.L95L		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	95	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GATATTTATCCTGGTCTGCAT	0.433													19	119					0	0	0.000958276	0	0
DNAH5	1767	broad.mit.edu	37	5	13753548	13753548	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:13753548G>A	uc003jfd.2	-	63	10708	c.10666C>T	c.(10666-10668)CCA>TCA	p.P3556S	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3556					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTTCCAAATGGAATTTTCCGG	0.403									Kartagener_syndrome				30	110					0	0	0.001512	0	0
CDH18	1016	broad.mit.edu	37	5	19503127	19503127	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:19503127G>A	uc003jgc.2	-	10	1981	c.1604C>T	c.(1603-1605)CCA>CTA	p.P535L	CDH18_uc003jgd.2_Missense_Mutation_p.P535L|CDH18_uc011cnm.1_Missense_Mutation_p.P535L	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	535	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGTGAAGTTTGGATTTACAGG	0.348													22	43					0	0	0.00188189	0	0
CDH6	1004	broad.mit.edu	37	5	31267675	31267675	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:31267675C>A	uc003jhe.1	+	2	421	c.95C>A	c.(94-96)CCA>CAA	p.P32Q	CDH6_uc003jhd.1_Missense_Mutation_p.P32Q	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	32					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						AGTGGTTTCCCAGCAAAGAAA	0.488													34	56					8.73648e-17	3.22404e-16	0.000814825	1	0
ZFR	51663	broad.mit.edu	37	5	32400223	32400223	+	Silent	SNP	A	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:32400223A>C	uc003jhr.1	-	9	1682	c.1602T>G	c.(1600-1602)GCT>GCG	p.A534A		NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	534					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		GAATCTGCACAGCAGAAGTGA	0.433													11	47					0	0	0.000978159	0	0
AGXT2	64902	broad.mit.edu	37	5	35040730	35040730	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:35040730G>A	uc003jjf.2	-	2	206	c.127C>T	c.(127-129)CAT>TAT	p.H43Y	AGXT2_uc011com.1_Missense_Mutation_p.H43Y|AGXT2_uc011con.1_Intron	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	43					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GGCTTTGTATGAAGACTGAGC	0.438													55	104					0	0	0.000781405	0	0
NNT	23530	broad.mit.edu	37	5	43628326	43628326	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:43628326G>A	uc003joe.2	+	7	1056	c.801G>A	c.(799-801)AAG>AAA	p.K267K	NNT_uc003jof.2_Silent_p.K267K	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	267	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	AACAGTTCAAGTCTCTTGGTG	0.418													35	96					0	0	0.000953801	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65350368	65350368	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:65350368C>T	uc003juk.1	+	21	3530	c.3222C>T	c.(3220-3222)ATC>ATT	p.I1074I	ERBB2IP_uc003jui.1_Silent_p.I1074I|ERBB2IP_uc003juj.1_Silent_p.I1074I|ERBB2IP_uc011cqx.1_Silent_p.I1074I|ERBB2IP_uc011cqy.1_Silent_p.I1074I|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Silent_p.I1070I|ERBB2IP_uc003jul.1_Silent_p.I1070I	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	1074					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		GAAGTACAATCCAGCGACAAA	0.473													39	45					0	0	0.00285205	0	0
MAN2A1	4124	broad.mit.edu	37	5	109125208	109125208	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:109125208A>G	uc003kou.1	+	12	2886	c.1923A>G	c.(1921-1923)ATA>ATG	p.I641M		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	641	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		AAAATATAATAAGGCTGAGTG	0.299													4	8					0	0	0.000602214	0	0
MAN2A1	4124	broad.mit.edu	37	5	109181655	109181655	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:109181655T>G	uc003kou.1	+	18	3753	c.2790T>G	c.(2788-2790)CAT>CAG	p.H930Q		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	930	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		ATGCCAAACATCGTTTGACAC	0.408													47	37					0	0	0.000781405	0	0
ZNF474	133923	broad.mit.edu	37	5	121488488	121488488	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:121488488C>T	uc003ksv.2	+	2	1179	c.803C>T	c.(802-804)CCC>CTC	p.P268L		NM_207317	NP_997200	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	268						intracellular	zinc ion binding				0		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		AAGCCTCAGCCCCTTCCGAAT	0.542													24	13					0	0	0.00127121	0	0
SNCAIP	9627	broad.mit.edu	37	5	121761086	121761086	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:121761086G>A	uc003ksw.1	+	5	1248	c.1042G>A	c.(1042-1044)GAA>AAA	p.E348K	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.E348K|SNCAIP_uc003ksx.1_Missense_Mutation_p.E395K|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.E42K|SNCAIP_uc010jcx.1_Intron	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	348					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AATTCACGACGAAAATGGAAA	0.438													49	46					0	0	0.000781405	0	0
ANKRD43	134548	broad.mit.edu	37	5	132150952	132150952	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:132150952C>A	uc003kxw.2	+	1	1920	c.1639C>A	c.(1639-1641)CCA>ACA	p.P547T		NM_175873	NP_787069	Q2M3V2	ANR43_HUMAN	ankyrin repeat domain 43 precursor	547											0		all_cancers(142;0.086)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGTTTTCCTCCAACAACCTG	0.567													13	8					2.62699e-14	9.65291e-14	0.000308642	1	0
CAMLG	819	broad.mit.edu	37	5	134086595	134086595	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:134086595C>T	uc003kzt.2	+	4	951	c.846C>T	c.(844-846)ATC>ATT	p.I282I	CAMLG_uc003kzu.2_3'UTR	NM_001745	NP_001736	P49069	CAMLG_HUMAN	calcium modulating ligand	282	Cytoplasmic (Potential).				defense response	endoplasmic reticulum|integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	TCACTTTTATCTTTTGTCATG	0.383													18	25					0	0	0.00074312	0	0
HARS2	23438	broad.mit.edu	37	5	140076761	140076761	+	Missense_Mutation	SNP	C	T	T	rs75387627		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:140076761C>T	uc003lgx.2	+	10	1183	c.967C>T	c.(967-969)CTC>TTC	p.L323F	HARS2_uc011czr.1_Missense_Mutation_p.L298F|HARS2_uc011czs.1_Missense_Mutation_p.L179F|HARS2_uc011czt.1_Missense_Mutation_p.L151F|HARS2_uc011czu.1_Missense_Mutation_p.L149F	NM_012208	NP_036340	P49590	SYHM_HUMAN	histidyl-tRNA synthetase 2 precursor	323					histidyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|histidine-tRNA ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCTTTGACCTCAGCCTGGC	0.557													39	50					0	0	0.00170553	0	0
PCDHB11	56125	broad.mit.edu	37	5	140579362	140579362	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:140579362G>A	uc003liy.2	+	1	15	c.15G>A	c.(13-15)GGG>GGA	p.G5G	PCDHB11_uc011daj.1_5'UTR	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	5					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAACCAAGGGACACGCACTC	0.498													17	15					0	0	0.000566183	0	0
PCDHB18	54660	broad.mit.edu	37	5	140615806	140615806	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:140615806C>T	uc003ljc.1	+	1	1869	c.1521C>T	c.(1519-1521)TTC>TTT	p.F507F		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						ACTCGCCCTTCGTGCTGTACC	0.716													18	22					0	0	0.00229938	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140750125	140750125	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:140750125G>A	uc003ljw.1	+	1	164	c.164G>A	c.(163-165)GGG>GAG	p.G55E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Missense_Mutation_p.G55E	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	55	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGACCTGGGGTTTGGCGTG	0.547													47	61					0	0	0.000781405	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140778884	140778884	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:140778884C>T	uc003lkf.1	+	1	1190	c.1190C>T	c.(1189-1191)TCG>TTG	p.S397L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.S397L	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	397	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAAAAATTCGTATAAGTTG	0.458													13	23					0	0	0.00185496	0	0
PCDH12	51294	broad.mit.edu	37	5	141336315	141336315	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:141336315G>A	uc003llx.2	-	1	2313	c.1102C>T	c.(1102-1104)CCC>TCC	p.P368S		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	368	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTCCTTGGGAAGAGCTTCT	0.507													42	49					0	0	0.00222228	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147040531	147040531	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:147040531C>T	uc003loq.1	-	3	989	c.607G>A	c.(607-609)GAG>AAG	p.E203K	JAKMIP2_uc011dbx.1_Missense_Mutation_p.E161K|JAKMIP2_uc003lor.1_Missense_Mutation_p.E203K|uc003lop.1_3'UTR|JAKMIP2_uc010jgo.1_Missense_Mutation_p.E203K	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	203						Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATATCCCGCTCCGACTCCCAC	0.502													31	50					0	0	0.0024448	0	0
UBLCP1	134510	broad.mit.edu	37	5	158697388	158697388	+	Silent	SNP	C	T	T	rs145226059		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:158697388C>T	uc003lxq.2	+	4	593	c.267C>T	c.(265-267)CCC>CCT	p.P89P		NM_145049	NP_659486	Q8WVY7	UBCP1_HUMAN	ubiquitin-like domain containing CTD phosphatase	89						nucleus	phosphoprotein phosphatase activity			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TAGGTCCACCCCCTGACAATG	0.313													25	42					0	0	0.00127121	0	0
MAT2B	27430	broad.mit.edu	37	5	162944660	162944660	+	Missense_Mutation	SNP	C	T	T	rs77428501		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr5:162944660C>T	uc003lzk.2	+	6	922	c.814C>T	c.(814-816)CCC>TCC	p.P272S	MAT2B_uc003lzj.2_Missense_Mutation_p.P261S|MAT2B_uc003lzl.1_3'UTR|MAT2B_uc003lzm.2_Missense_Mutation_p.P12S	NM_013283	NP_037415	Q9NZL9	MAT2B_HUMAN	methionine adenosyltransferase II, beta isoform	272					extracellular polysaccharide biosynthetic process|methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol|methionine adenosyltransferase complex|nucleus	dTDP-4-dehydrorhamnose reductase activity|methionine adenosyltransferase regulator activity|protein binding			upper_aerodigestive_tract(1)	1	Renal(175;0.000281)	Medulloblastoma(196;0.0208)|all_neural(177;0.0765)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.027)|OV - Ovarian serous cystadenocarcinoma(192;0.0406)|Epithelial(171;0.0797)	L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	CTTCAACCTCCCCAGCAGTCA	0.403													14	11					0	0	0.000422831	0	0
SYCP2L	221711	broad.mit.edu	37	6	10942729	10942729	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:10942729C>T	uc003mzo.2	+	22	2147	c.1851C>T	c.(1849-1851)TCC>TCT	p.S617S	SYCP2L_uc010jow.2_Silent_p.S237S	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	617						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			AGCTCTCTTCCTTGAAGCACT	0.353													7	22					0	0	0.00198382	0	0
GMPR	2766	broad.mit.edu	37	6	16254963	16254963	+	Silent	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:16254963T>C	uc003nbs.2	+	4	576	c.462T>C	c.(460-462)ATT>ATC	p.I154I		NM_006877	NP_006868	P36959	GMPR1_HUMAN	guanosine monophosphate reductase	154					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage|response to cold	cytosol	GMP reductase activity|metal ion binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.103)	all_hematologic(90;0.0895)				AACACACCATTATGGTAAGTA	0.453													40	59					0	0	0.00285205	0	0
SLC17A1	6568	broad.mit.edu	37	6	25811930	25811930	+	Silent	SNP	T	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:25811930T>G	uc003nfh.3	-	9	1082	c.966A>C	c.(964-966)TCA>TCC	p.S322S	SLC17A1_uc011djy.1_RNA|SLC17A1_uc010jqb.1_Silent_p.S320S|SLC17A1_uc010jqc.1_Silent_p.S266S	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	322					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						GGAAGAAGTCTGATAACTGAC	0.448													17	41					0	0	0.00074312	0	0
HIST1H2BH	8345	broad.mit.edu	37	6	26252092	26252092	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:26252092G>A	uc003nhh.2	+	1	214	c.214G>A	c.(214-216)GAG>AAG	p.E72K	HIST1H3F_uc003nhg.1_5'Flank	NM_003524	NP_003515	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	72					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)	3						CGATATCTTCGAGCGCATCGC	0.577													39	91					0	0	0.00111076	0	0
BTN1A1	696	broad.mit.edu	37	6	26505364	26505364	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:26505364G>A	uc003nif.3	+	3	659	c.639G>A	c.(637-639)GCG>GCA	p.A213A		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	213	Extracellular (Potential).|Ig-like V-type 2.					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						ACACTTCTGCGAAAAATGTGT	0.453													41	70					0	0	0.00222228	0	0
PRSS16	10279	broad.mit.edu	37	6	27215814	27215814	+	Missense_Mutation	SNP	G	A	A	rs150849072	byFrequency	TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:27215814G>A	uc003nja.2	+	2	236	c.224G>A	c.(223-225)CGA>CAA	p.R75Q	PRSS16_uc011dkt.1_RNA|PRSS16_uc003njb.2_Missense_Mutation_p.R75Q|PRSS16_uc010jqq.1_5'Flank|PRSS16_uc010jqr.1_5'Flank|PRSS16_uc003njc.1_5'Flank	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	75					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						TCCGACAGACGATCCTTCCTA	0.617													8	34					0	0	0.000157383	0	0
NKAPL	222698	broad.mit.edu	37	6	28227309	28227310	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:28227309_28227310CC>TT	uc003nkt.2	+	1	212_213	c.160_161CC>TT	c.(160-162)CCT>TTT	p.P54F	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	54										upper_aerodigestive_tract(1)|ovary(1)	2						CCTCAGGCCTCCTTGGAGTGAG	0.653													22	52					0	0	6.4e-05	0	0
SKIV2L	6499	broad.mit.edu	37	6	31933721	31933721	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:31933721C>T	uc003nyn.1	+	18	2522	c.2133C>T	c.(2131-2133)CCC>CCT	p.P711P	SKIV2L_uc011dou.1_Silent_p.P553P|SKIV2L_uc011dov.1_Silent_p.P518P	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	711	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						GCCTGGACCCCACAGGCACCG	0.667													77	179					0	0	0.000781405	0	0
TNXB	7148	broad.mit.edu	37	6	32032745	32032745	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:32032745C>T	uc003nzl.2	-	19	6896	c.6694G>A	c.(6694-6696)GAC>AAC	p.D2232N		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2304	Fibronectin type-III 15.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GGCTGCCCGTCCCCATTCTTA	0.597													153	306					0	0	0.000781405	0	0
HLA-DQA2	3118	broad.mit.edu	37	6	32713056	32713056	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:32713056T>C	uc003obx.2	+	2	261	c.203T>C	c.(202-204)GTC>GCC	p.V68A		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	68	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAAGAGACTGTCTGGCAGTTG	0.468													24	64					0	0	0.000586117	0	0
COL11A2	1302	broad.mit.edu	37	6	33145223	33145223	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:33145223C>T	uc003ocx.1	-	23	2165	c.1937G>A	c.(1936-1938)GGA>GAA	p.G646E	COL11A2_uc010jul.1_Missense_Mutation_p.D26N|COL11A2_uc003ocy.1_Missense_Mutation_p.G560E|COL11A2_uc003ocz.1_Missense_Mutation_p.G539E	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	646	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TCCAGGAGGTCCTGGCTCTCC	0.582													15	26					0	0	0.000308642	0	0
ITPR3	3710	broad.mit.edu	37	6	33639930	33639930	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:33639930G>A	uc011drk.1	+	22	3072	c.2853G>A	c.(2851-2853)CTG>CTA	p.L951L		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	951	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CTGAGCCGCTGGACAGAAGCA	0.597													22	55					0	0	0.00047179	0	0
IP6K3	117283	broad.mit.edu	37	6	33703227	33703227	+	Silent	SNP	G	A	A	rs150212654		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:33703227G>A	uc010jvf.2	-	3	563	c.27C>T	c.(25-27)GCC>GCT	p.A9A	IP6K3_uc003ofb.2_Silent_p.A9A	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	9					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						TCATGTCCCCGGCGTCTGCGC	0.617													9	25					0	0	0.000978159	0	0
MLN	4295	broad.mit.edu	37	6	33768863	33768863	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:33768863G>A	uc003off.1	-	2	149	c.78C>T	c.(76-78)TTC>TTT	p.F26F	MLN_uc003ofg.1_Silent_p.F26F|MLN_uc011drn.1_Silent_p.F26F	NM_002418	NP_002409	P12872	MOTI_HUMAN	motilin isoform 1 preproprotein	26					cell-cell signaling|G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	hormone activity				0						AGATGGGGACGAAGGCTTCCG	0.582													45	104					0	0	0.000781405	0	0
DEF6	50619	broad.mit.edu	37	6	35280207	35280208	+	Silent	DNP	CC	TT	TT	rs146706360		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:35280207_35280208CC>TT	uc003okk.2	+	4	591_592	c.552_553CC>TT	c.(550-555)TTCCTG>TTTTTG	p.184_185FL>FL	DEF6_uc010jvs.2_Silent_p.184_185FL>FL|DEF6_uc010jvt.2_Intron	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	184_185						cytoplasm|nucleus|plasma membrane					0						TCTGGCAGTTCCTGGAGCTCTT	0.658													25	73					0	0	6.4e-05	0	0
TULP1	7287	broad.mit.edu	37	6	35478645	35478645	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:35478645G>A	uc003okv.3	-	5	504	c.492C>T	c.(490-492)GGC>GGT	p.G164G	TULP1_uc003okw.3_Silent_p.G111G	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	164					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						CACCCCTTGGGCCCTGGGCCT	0.547													34	65					0	0	0.0025221	0	0
DNAH8	1769	broad.mit.edu	37	6	38899763	38899763	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:38899763G>A	uc003ooe.1	+	74	11400	c.10800G>A	c.(10798-10800)GAG>GAA	p.E3600E	DNAH8_uc003oog.1_Silent_p.E49E|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTCTAACAGAGAAACAGGTAA	0.318													19	57					0	0	0.000958276	0	0
ABCC10	89845	broad.mit.edu	37	6	43406504	43406504	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:43406504G>A	uc003ouy.1	+	8	2313	c.2098G>A	c.(2098-2100)GAA>AAA	p.E700K	ABCC10_uc003ouz.1_Missense_Mutation_p.E672K|ABCC10_uc010jyo.1_5'UTR	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	700	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGAGGTGCTAGAAGCCTGCGC	0.547													30	52					0	0	0.00283554	0	0
GPR115	221393	broad.mit.edu	37	6	47682748	47682748	+	Silent	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:47682748T>C	uc003oza.1	+	6	2025	c.1767T>C	c.(1765-1767)ATT>ATC	p.I589I	GPR115_uc003oyz.1_Silent_p.I646I|GPR115_uc003ozb.1_Silent_p.I587I	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	589	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						GGCCCTCTATTGGCAGTTCCA	0.478													57	97					0	0	0.000781405	0	0
FAM83B	222584	broad.mit.edu	37	6	54805208	54805208	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:54805208G>A	uc003pck.2	+	5	1555	c.1439G>A	c.(1438-1440)CGA>CAA	p.R480Q		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	480										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TTGCAACAACGAATGCCAACC	0.413													22	41					0	0	0.00188189	0	0
DST	667	broad.mit.edu	37	6	56328382	56328382	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:56328382G>A	uc003pdf.2	-	94	16539	c.16511C>T	c.(16510-16512)CCT>CTT	p.P5504L	DST_uc003pcz.3_Missense_Mutation_p.P5326L|DST_uc011dxj.1_Missense_Mutation_p.P5355L|DST_uc011dxk.1_Missense_Mutation_p.P5366L|DST_uc003pcy.3_Missense_Mutation_p.P5000L|DST_uc003pcv.3_Missense_Mutation_p.P122L|DST_uc003pcw.3_Missense_Mutation_p.P83L|DST_uc003pcx.3_Missense_Mutation_p.P83L	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7436					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GGTGGTGGCAGGGACCTGTGG	0.562													25	40					0	0	0.00106085	0	0
GPRC6A	222545	broad.mit.edu	37	6	117127921	117127921	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:117127921T>C	uc003pxj.1	-	3	969	c.947A>G	c.(946-948)AAT>AGT	p.N316S	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Missense_Mutation_p.N316S	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	316	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CTTTTTAACATTAGGAATGGT	0.363													13	45					0	0	0.00185496	0	0
ROS1	6098	broad.mit.edu	37	6	117724339	117724339	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:117724339G>A	uc003pxp.1	-	6	739	c.540C>T	c.(538-540)TCC>TCT	p.S180S	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	180	Fibronectin type-III 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GACTTGGAGGGGAGTAGAGCT	0.478			T	GOPC|ROS1	glioblastoma|NSCLC								28	65					0	0	0.001512	0	0
C6orf170	221322	broad.mit.edu	37	6	121625524	121625524	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:121625524G>A	uc003pyo.1	-	8	990	c.922C>T	c.(922-924)CGT>TGT	p.R308C	C6orf170_uc003pyq.1_RNA	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	308					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		TCTGGATGACGAATCCAGAAA	0.398													18	47					0	0	0.00121646	0	0
NKAIN2	154215	broad.mit.edu	37	6	124604234	124604234	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:124604234C>T	uc003pzo.2	+	2	415	c.138C>T	c.(136-138)ATC>ATT	p.I46I	NKAIN2_uc003pzn.1_Silent_p.I46I|NKAIN2_uc003pzp.2_Silent_p.I45I|NKAIN2_uc010keq.2_Silent_p.I46I|NKAIN2_uc010ker.2_5'UTR|NKAIN2_uc010kep.1_RNA	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	46	Helical; (Potential).					integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		ATATTATTATCGTCATTCTTG	0.348													27	61					0	0	0.00106085	0	0
LAMA2	3908	broad.mit.edu	37	6	129759851	129759851	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:129759851G>A	uc003qbn.2	+	42	6134	c.6029G>A	c.(6028-6030)GGG>GAG	p.G2010E	LAMA2_uc003qbo.2_Missense_Mutation_p.G2010E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2010	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCTAGAAATGGGGATCTCTTG	0.348													26	49					0	0	0.001512	0	0
AKAP7	9465	broad.mit.edu	37	6	131520696	131520696	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:131520696C>T	uc003qck.2	+	6	718	c.685C>T	c.(685-687)CCG>TCG	p.P229S	AKAP7_uc011ebz.1_Missense_Mutation_p.P207S|AKAP7_uc003qcl.1_Missense_Mutation_p.P110S	NM_016377	NP_057461	O43687	AKA7A_HUMAN	A-kinase anchor protein 7 isoform gamma	Error:Variant_position_missing_in_O43687_after_alignment					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			ovary(2)	2	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)		GTCAAAATCACCGTGGCTCCG	0.448											OREG0017662	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	23					0	0	0.00198382	0	0
MED23	9439	broad.mit.edu	37	6	131927666	131927666	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:131927666G>A	uc003qcs.1	-	13	1494	c.1320C>T	c.(1318-1320)AAC>AAT	p.N440N	MED23_uc003qcq.2_Silent_p.N446N|MED23_uc011eca.1_Silent_p.N81N|MED23_uc003qct.1_Silent_p.N446N|MED23_uc011ecb.1_RNA	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	440					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		GTAGCTTGGAGTTGTCATTTT	0.358													25	39					0	0	0.000720815	0	0
MAP3K5	4217	broad.mit.edu	37	6	136934291	136934291	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:136934291G>A	uc003qhc.2	-	17	2743	c.2382C>T	c.(2380-2382)CTC>CTT	p.L794L	MAP3K5_uc011edj.1_Silent_p.L41L|MAP3K5_uc011edk.1_Silent_p.L639L	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	794	Protein kinase.				activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GATTGTCATGGAGATATTTTA	0.373													18	55					0	0	0.00188189	0	0
LPA	4018	broad.mit.edu	37	6	161071527	161071527	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:161071527C>T	uc003qtl.2	-	3	172	c.52G>A	c.(52-54)GCA>ACA	p.A18T		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGCTCAGGTGCTGCTAAAATT	0.423													52	109					0	0	0.000781405	0	0
C6orf118	168090	broad.mit.edu	37	6	165715235	165715235	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:165715235G>A	uc003qum.3	-	2	612	c.576C>T	c.(574-576)TCC>TCT	p.S192S	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	192											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TGGTGCCTCTGGACCCGGCCT	0.642													23	38					0	0	0.00229938	0	0
DGKB	1607	broad.mit.edu	37	7	14880876	14880876	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:14880876C>T	uc003ssz.2	-	1	200	c.13G>A	c.(13-15)GAA>AAA	p.E5K	DGKB_uc011jxt.1_Missense_Mutation_p.E5K|DGKB_uc003sta.2_Missense_Mutation_p.E5K|DGKB_uc011jxu.1_Missense_Mutation_p.E5K|DGKB_uc011jxv.1_Missense_Mutation_p.E5K	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	5					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	GCCCATTTTTCCTGGTTTGTC	0.403													8	21					0	0	0.000274275	0	0
HDAC9	9734	broad.mit.edu	37	7	18975497	18975497	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:18975497G>A	uc003suh.2	+	22	2901	c.2860G>A	c.(2860-2862)GGA>AGA	p.G954R	HDAC9_uc003sue.2_Missense_Mutation_p.G954R|HDAC9_uc003sui.2_Missense_Mutation_p.G957R|HDAC9_uc003suj.2_Missense_Mutation_p.G913R|HDAC9_uc003suk.2_Missense_Mutation_p.G202R	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	954	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	GGCTCTAGAAGGAGGACATGA	0.418													71	143					0	0	0.000781405	0	0
STK31	56164	broad.mit.edu	37	7	23808674	23808674	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:23808674G>A	uc003sws.3	+	12	1544	c.1477G>A	c.(1477-1479)GAA>AAA	p.E493K	STK31_uc003swt.3_Missense_Mutation_p.E470K|STK31_uc011jze.1_Missense_Mutation_p.E493K|STK31_uc010kuq.2_Missense_Mutation_p.E470K	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	493							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						AAATTCTGATGAAATACTTAA	0.368													36	38					0	0	0.000953801	0	0
BMPER	168667	broad.mit.edu	37	7	34192725	34192725	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:34192725C>T	uc011kap.1	+	15	2012	c.1898C>T	c.(1897-1899)GCT>GTT	p.A633V		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	633	TIL.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						AAGCATGGTGCTGTGTACGAT	0.507													46	58					0	0	0.000781405	0	0
NPC1L1	29881	broad.mit.edu	37	7	44578891	44578891	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:44578891C>T	uc003tlb.2	-	2	1161	c.1105G>A	c.(1105-1107)GGC>AGC	p.G369S	NPC1L1_uc003tlc.2_Missense_Mutation_p.G369S|NPC1L1_uc011kbw.1_Missense_Mutation_p.G369S|NPC1L1_uc003tld.2_Missense_Mutation_p.G369S	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	369	Helical; Name=2; (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	AAGACCAGGCCCGCTGCCAAG	0.617													37	30					0	0	0.000692331	0	0
ABCA13	154664	broad.mit.edu	37	7	48269424	48269424	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:48269424C>T	uc003toq.2	+	7	660	c.635C>T	c.(634-636)TCC>TTC	p.S212F	ABCA13_uc003top.2_3'UTR|ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	212					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GGTTCTAGTTCCTTAATATCC	0.388													74	86					0	0	0.000781405	0	0
ZNF679	168417	broad.mit.edu	37	7	63720662	63720662	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:63720662C>T	uc003tsx.2	+	3	372	c.103C>T	c.(103-105)CAC>TAC	p.H35Y		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATGCCTGGATCACGCTCAGCA	0.383													25	49					0	0	0.000720815	0	0
GRM3	2913	broad.mit.edu	37	7	86415877	86415877	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:86415877G>A	uc003uid.2	+	3	1868	c.769G>A	c.(769-771)GAC>AAC	p.D257N	GRM3_uc010lef.2_Missense_Mutation_p.D255N|GRM3_uc010leg.2_Missense_Mutation_p.D129N|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	257	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CAAGTCCTACGACAGCGTGAT	0.647													23	44					0	0	0.00278032	0	0
GRM3	2913	broad.mit.edu	37	7	86468876	86468876	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:86468876C>T	uc003uid.2	+	4	3145	c.2046C>T	c.(2044-2046)TTC>TTT	p.F682F	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Silent_p.F554F|GRM3_uc010leh.2_Silent_p.F274F	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	682	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGCCAAAATTCATCAGCCCCA	0.542													21	51					0	0	0.00121646	0	0
CYP3A5	1577	broad.mit.edu	37	7	99258142	99258142	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:99258142C>T	uc003urq.2	-	10	1093	c.1006G>A	c.(1006-1008)GAT>AAT	p.D336N	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_Missense_Mutation_p.D156N|CYP3A5_uc003urr.2_Missense_Mutation_p.D223N|CYP3A5_uc011kiy.1_Missense_Mutation_p.D326N|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	336					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	AAAACTGCATCAATCTCCTTT	0.478													40	97					0	0	0.00170553	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99621901	99621901	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:99621901C>T	uc003usk.1	+	3	770	c.551C>T	c.(550-552)TCT>TTT	p.S184F	ZKSCAN1_uc003usj.2_Missense_Mutation_p.S183F|ZKSCAN1_uc003usl.1_Missense_Mutation_p.S148F|ZKSCAN1_uc003usm.1_Intron	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	184					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			AAACATTCGTCTCGGAAACCC	0.532													24	30					0	0	0.000586117	0	0
ZAN	7455	broad.mit.edu	37	7	100386959	100386959	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:100386959G>A	uc003uwj.2	+	40	7512	c.7347G>A	c.(7345-7347)AGG>AGA	p.R2449R	ZAN_uc003uwk.2_Silent_p.R2449R|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.R499R	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2449	VWFD 4.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTGGTGGAAGGAAAAATGCAG	0.537													28	79					0	0	0.00209593	0	0
MUC17	140453	broad.mit.edu	37	7	100686452	100686452	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:100686452C>T	uc003uxp.1	+	3	11808	c.11755C>T	c.(11755-11757)CCT>TCT	p.P3919S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3919	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCCACAATTCCTGTAGCCAC	0.493													54	112					0	0	0.000781405	0	0
MUC17	140453	broad.mit.edu	37	7	100687013	100687014	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:100687013_100687014CC>TT	uc003uxp.1	+	3	12369_12370	c.12316_12317CC>TT	c.(12316-12318)CCC>TTC	p.P4106F	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4106	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACTTCCTTCCCCACGGTGACC	0.535													26	46					0	0	6.4e-05	0	0
CDHR3	222256	broad.mit.edu	37	7	105656440	105656440	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:105656440C>T	uc003vdl.3	+	11	1503	c.1395C>T	c.(1393-1395)TCC>TCT	p.S465S	CDHR3_uc003vdk.2_Silent_p.S113S|CDHR3_uc003vdm.3_Silent_p.S452S|CDHR3_uc011klt.1_Silent_p.S377S|CDHR3_uc003vdn.2_Silent_p.S182S	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	465	Cadherin 4.|Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						ATAGGCCATCCTATGTATTTG	0.393													12	16					0	0	0.00185496	0	0
SLC26A4	5172	broad.mit.edu	37	7	107340578	107340578	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:107340578C>T	uc003vep.2	+	15	1889	c.1665C>T	c.(1663-1665)TTC>TTT	p.F555F	SLC26A4_uc011kmb.1_Silent_p.F142F|SLC26A4_uc011kmc.1_Silent_p.F116F|SLC26A4_uc011kmd.1_Silent_p.F124F	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	555	STAS.|Cytoplasmic (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						GTCCTATTTTCTATGGCAATG	0.308									Pendred_syndrome				22	46					0	0	0.000586117	0	0
ASZ1	136991	broad.mit.edu	37	7	117062383	117062383	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:117062383C>T	uc003vjb.2	-	3	299	c.236G>A	c.(235-237)GGA>GAA	p.G79E	ASZ1_uc011kno.1_Missense_Mutation_p.G79E|ASZ1_uc011knp.1_5'UTR	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	79	ANK 2.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			GGGAGTCCATCCATACTGAAA	0.413													30	37					0	0	0.001512	0	0
HYAL4	23553	broad.mit.edu	37	7	123508936	123508936	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:123508936C>T	uc003vlc.2	+	3	1247	c.609C>T	c.(607-609)ATC>ATT	p.I203I	HYAL4_uc011knz.1_Silent_p.I203I	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	203	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						AGGAAACCATCAAATTGGGAA	0.378													54	61					0	0	0.000781405	0	0
RBM28	55131	broad.mit.edu	37	7	127961330	127961330	+	Missense_Mutation	SNP	G	A	A	rs138112810	byFrequency	TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:127961330G>A	uc003vmp.2	-	14	1667	c.1552C>T	c.(1552-1554)CGC>TGC	p.R518C	RBM28_uc003vmo.2_Missense_Mutation_p.R135C|RBM28_uc011koj.1_Missense_Mutation_p.R377C	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	518	RRM 4.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						TCCTTGATGCGCACCCCTTTC	0.517													102	82					0	0	0.000781405	0	0
FLNC	2318	broad.mit.edu	37	7	128485029	128485029	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:128485029C>T	uc003vnz.3	+	21	3719	c.3510C>T	c.(3508-3510)GTC>GTT	p.V1170V	FLNC_uc003voa.3_Silent_p.V1170V	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1170	Filamin 10.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GCGGCAAGGTCGGTGAGGCAG	0.657													11	58					0	0	0.000978159	0	0
SVOPL	136306	broad.mit.edu	37	7	138305866	138305866	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:138305866C>T	uc011kqh.1	-	13	1278	c.1278G>A	c.(1276-1278)ACG>ACA	p.T426T	SVOPL_uc003vue.2_Silent_p.T274T	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	426						integral to membrane	transmembrane transporter activity				0						AAGCGCGCATCGTGGTGGGGT	0.602													13	15					0	0	0.00244969	0	0
SVOPL	136306	broad.mit.edu	37	7	138347878	138347878	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:138347878C>T	uc011kqh.1	-	4	286	c.286G>A	c.(286-288)GGC>AGC	p.G96S	SVOPL_uc003vue.2_5'UTR	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	96	Helical; (Potential).					integral to membrane	transmembrane transporter activity				0						ACCATGTAGCCAAAAAACACC	0.463													36	42					0	0	0.000692331	0	0
TTC26	79989	broad.mit.edu	37	7	138819411	138819411	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:138819411G>A	uc003vus.2	+	2	128	c.14G>A	c.(13-15)AGG>AAG	p.R5K	TTC26_uc003vuq.2_Missense_Mutation_p.R5K|TTC26_uc011kqm.1_Missense_Mutation_p.R5K|TTC26_uc003vur.3_Missense_Mutation_p.R5K|TTC26_uc011kqn.1_Missense_Mutation_p.R5K|TTC26_uc011kqo.1_Missense_Mutation_p.R5K|TTC26_uc011kqp.1_5'UTR|TTC26_uc003vut.2_5'UTR|TTC26_uc011kqq.1_Missense_Mutation_p.R5K	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	5							binding			ovary(1)	1						ATGCTTTCAAGGGCCAAACCT	0.383													35	27					0	0	0.00111076	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				48	44					0	0	0.000781405	0	0
PRSS37	136242	broad.mit.edu	37	7	141536257	141536257	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:141536257C>T	uc003vws.1	-	5	1018	c.646G>A	c.(646-648)GGC>AGC	p.G216S	PRSS37_uc011krk.1_Missense_Mutation_p.G203S|PRSS37_uc011krl.1_Missense_Mutation_p.G215S|PRSS37_uc003vwt.1_Missense_Mutation_p.G203S	NM_001008270	NP_001008271	A4D1T9	PRS37_HUMAN	protease, serine, 37 precursor	216	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			skin(1)	1						GTGTAGATGCCGACGTCCCCT	0.507													32	111					0	0	0.00058488	0	0
OR9A4	130075	broad.mit.edu	37	7	141619380	141619380	+	Silent	SNP	G	A	A	rs143629932		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:141619380G>A	uc003vwu.1	+	1	705	c.705G>A	c.(703-705)AGG>AGA	p.R235R		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R235R(1)		skin(1)	1	Melanoma(164;0.0171)					CTGGCCGGAGGAAATCCTTCT	0.502													28	127					0	0	0.00106085	0	0
TRY6	154754	broad.mit.edu	37	7	142481160	142481160	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:142481160C>T	uc011ksq.1	+	3	317	c.234C>T	c.(232-234)ATC>ATT	p.I78I	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|uc003wan.1_Intron|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						AGCACAATATCGAAGTCCTGG	0.522													45	10					0	0	0.000781405	0	0
ZNF775	285971	broad.mit.edu	37	7	150095105	150095105	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:150095105C>T	uc003whf.1	+	3	1661	c.1536C>T	c.(1534-1536)AGC>AGT	p.S512S	LOC728743_uc003whg.2_5'Flank	NM_173680	NP_775951	Q96BV0	ZN775_HUMAN	zinc finger protein 775	512	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCGGCTTCAGCCAGAAGCAGC	0.726													3	6					0	0	6.4e-05	0	0
XRCC2	7516	broad.mit.edu	37	7	152346130	152346130	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:152346130A>G	uc003wld.2	-	3	526	c.440T>C	c.(439-441)ATT>ACT	p.I147T		NM_005431	NP_005422	O43543	XRCC2_HUMAN	X-ray repair cross complementing protein 2	147					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			breast(1)|liver(1)	2		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		GCTATCCAAAATCAAAAGGCA	0.408								Homologous_recombination					20	69					0	0	0.00121646	0	0
PTPRN2	5799	broad.mit.edu	37	7	157926650	157926650	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr7:157926650C>T	uc003wno.2	-	9	1396	c.1275G>A	c.(1273-1275)AGG>AGA	p.R425R	PTPRN2_uc003wnp.2_Silent_p.R408R|PTPRN2_uc003wnq.2_Silent_p.R425R|PTPRN2_uc003wnr.2_Silent_p.R387R|PTPRN2_uc011kwa.1_Silent_p.R448R	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	425	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CGGACTTCTTCCTCTCCATGT	0.597													72	79					0	0	0.000781405	0	0
CNOT7	29883	broad.mit.edu	37	8	17094725	17094725	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:17094725G>A	uc003wxf.1	-	4	637	c.469C>T	c.(469-471)CAT>TAT	p.H157Y	CNOT7_uc003wxg.1_Missense_Mutation_p.H157Y|CNOT7_uc003wxh.1_Missense_Mutation_p.H157Y	NM_013354	NP_037486	Q9UIV1	CNOT7_HUMAN	CCR4-NOT transcription complex, subunit 7	157					carbohydrate metabolic process|nuclear-transcribed mRNA poly(A) tail shortening	CCR4-NOT complex|cytoplasmic mRNA processing body|cytosol	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1				Colorectal(111;0.0523)|COAD - Colon adenocarcinoma(73;0.209)		TTTTACCTATGAAATGACAAC	0.383													19	67					0	0	0.00188189	0	0
LOXL2	4017	broad.mit.edu	37	8	23174479	23174479	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:23174479C>T	uc003xdh.1	-	9	1958	c.1619G>A	c.(1618-1620)GGA>GAA	p.G540E	LOXL2_uc010lty.1_Missense_Mutation_p.G79E	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	540	SRCR 4.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		GCAGGCAACTCCGGCCCCGTA	0.662													10	25					0	0	0.000673444	0	0
PURG	29942	broad.mit.edu	37	8	30889984	30889984	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:30889984C>T	uc003xin.2	-	1	334	c.315G>A	c.(313-315)CTG>CTA	p.L105L	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Silent_p.L105L	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	105	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		GGGAGAGGGTCAGTTTACTCT	0.567													28	60					0	0	0.000878237	0	0
TACC1	6867	broad.mit.edu	37	8	38677043	38677043	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:38677043C>T	uc010lwp.2	+	3	660	c.281C>T	c.(280-282)TCA>TTA	p.S94L	TACC1_uc011lby.1_5'UTR|TACC1_uc003xma.2_Intron|TACC1_uc003xlz.2_5'UTR|TACC1_uc003xmc.3_5'UTR|TACC1_uc011lbz.1_Missense_Mutation_p.S110L|TACC1_uc003xmb.3_Missense_Mutation_p.S49L|TACC1_uc003xme.1_Intron|TACC1_uc003xmd.1_Intron|TACC1_uc010lwo.1_Intron|TACC1_uc003xmf.3_Intron|TACC1_uc011lca.1_Missense_Mutation_p.S94L|TACC1_uc011lcb.1_5'UTR|TACC1_uc011lcc.1_5'UTR|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_5'UTR|TACC1_uc010lwq.2_5'UTR	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	94					cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			ATTTTAGAATCACAAGAAGCT	0.348													9	20					0	0	0.000274275	0	0
PRKDC	5591	broad.mit.edu	37	8	48855781	48855781	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:48855781G>A	uc003xqi.2	-	10	1011	c.954C>T	c.(952-954)TCC>TCT	p.S318S	PRKDC_uc003xqj.2_Silent_p.S318S|PRKDC_uc011ldh.1_Silent_p.S318S	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	318	HEAT 1.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GTTTCAGAAAGGATTCCAGGG	0.368								NHEJ					10	24					0	0	0.00136819	0	0
SNTG1	54212	broad.mit.edu	37	8	51314860	51314860	+	Nonsense_Mutation	SNP	G	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:51314860G>T	uc010lxy.1	+	5	489	c.118G>T	c.(118-120)GAA>TAA	p.E40*	SNTG1_uc003xqs.1_Nonsense_Mutation_p.E40*|SNTG1_uc010lxz.1_Nonsense_Mutation_p.E40*|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	40					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GATGATCCAGGAACAGGATGT	0.383													35	77					6.97489e-18	2.57951e-17	0.000953801	1	0
PXDNL	137902	broad.mit.edu	37	8	52359701	52359701	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:52359701C>T	uc003xqu.3	-	12	1489	c.1388G>A	c.(1387-1389)GGC>GAC	p.G463D		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	463	Ig-like C2-type 3.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGTATGCTGGCCTTCCACAGG	0.522													34	72					0	0	0.0024448	0	0
COPS5	10987	broad.mit.edu	37	8	67963533	67963533	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:67963533G>A	uc003xxe.2	-	6	1034	c.703C>T	c.(703-705)CGC>TGC	p.R235C	COPS5_uc003xxd.2_Missense_Mutation_p.R171C|COPS5_uc003xxf.2_Missense_Mutation_p.R280C|COPS5_uc010lyu.1_RNA|COPS5_uc010lyv.1_Missense_Mutation_p.R235C	NM_006837	NP_006828	Q92905	CSN5_HUMAN	COP9 signalosome subunit 5	235					cullin deneddylation|transcription from RNA polymerase II promoter	eukaryotic translation initiation factor 3 complex|signalosome	metal ion binding|metallopeptidase activity|protein binding|transcription coactivator activity|translation initiation factor activity			ovary(1)|skin(1)	2	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00389)|OV - Ovarian serous cystadenocarcinoma(28;0.00691)|all cancers(69;0.0205)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AGCAATTTGCGATCCAAAGAG	0.308													27	58					0	0	0.00106085	0	0
EYA1	2138	broad.mit.edu	37	8	72127951	72127951	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:72127951G>A	uc003xys.3	-	14	1660	c.1373C>T	c.(1372-1374)CCA>CTA	p.P458L	EYA1_uc003xyr.3_Missense_Mutation_p.P423L|EYA1_uc003xyt.3_Missense_Mutation_p.P425L|EYA1_uc010lzf.2_Missense_Mutation_p.P385L|EYA1_uc003xyu.2_Missense_Mutation_p.P458L|EYA1_uc011lfe.1_Missense_Mutation_p.P452L|EYA1_uc003xyv.2_Missense_Mutation_p.P336L	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	458					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CCTCTTAGCTGGACCAAGCAG	0.468													10	27					0	0	0.000673444	0	0
VPS13B	157680	broad.mit.edu	37	8	100533237	100533237	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:100533237C>G	uc003yiv.2	+	30	4930	c.4819C>G	c.(4819-4821)CAG>GAG	p.Q1607E	VPS13B_uc003yiw.2_Missense_Mutation_p.Q1582E	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1607					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGATATTTACCAGTAAGTTTA	0.398													3	84					0	0	6.4e-05	0	0
RIMS2	9699	broad.mit.edu	37	8	105026819	105026819	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:105026819C>T	uc003yls.2	+	17	2771	c.2530C>T	c.(2530-2532)CCA>TCA	p.P844S	RIMS2_uc003ylp.2_Missense_Mutation_p.P1104S|RIMS2_uc003ylw.2_Missense_Mutation_p.P918S|RIMS2_uc003ylq.2_Missense_Mutation_p.P918S|RIMS2_uc003ylr.2_Missense_Mutation_p.P943S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1166					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.S844A(1)		ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TCCACAGCTTCCACCAAAGGG	0.448										HNSCC(12;0.0054)			13	46					0	0	0.000422831	0	0
EPPK1	83481	broad.mit.edu	37	8	144940720	144940720	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:144940720C>T	uc003zaa.1	-	2	14725	c.14712G>A	c.(14710-14712)AAG>AAA	p.K4904K		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4904	Plectin 61.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGGGCTGGTCCTTGGCGGGCA	0.697													26	81					0	0	0.000878237	0	0
KANK1	23189	broad.mit.edu	37	9	711620	711620	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:711620C>T	uc003zgl.1	+	7	1503	c.854C>T	c.(853-855)CCT>CTT	p.P285L	KANK1_uc003zgm.2_Missense_Mutation_p.P285L|KANK1_uc003zgn.1_Missense_Mutation_p.P285L|KANK1_uc003zgo.1_Missense_Mutation_p.P285L|KANK1_uc003zgp.1_Missense_Mutation_p.P285L|KANK1_uc003zgq.2_Missense_Mutation_p.P127L|KANK1_uc003zgr.1_Missense_Mutation_p.P127L|KANK1_uc003zgs.1_Missense_Mutation_p.P127L	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	285	Potential.				negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		CGAACCATCCCTGTGCTCCAG	0.542													26	33					0	0	0.00106085	0	0
GLIS3	169792	broad.mit.edu	37	9	4125859	4125859	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:4125859C>T	uc003zhw.1	-	2	200	c.6G>A	c.(4-6)ATG>ATA	p.M2I	GLIS3_uc003zhx.1_Missense_Mutation_p.M157I|GLIS3_uc003zic.1_Missense_Mutation_p.M157I|GLIS3_uc003zie.1_Missense_Mutation_p.M157I|GLIS3_uc010mhh.1_Missense_Mutation_p.M32I|GLIS3_uc003zid.1_Intron|GLIS3_uc010mhi.1_Intron|GLIS3_uc003zif.1_Intron|GLIS3_uc003zig.1_Missense_Mutation_p.M1I|GLIS3_uc003zih.1_Intron|GLIS3_uc003zib.1_Missense_Mutation_p.M1I|GLIS3_uc010mhg.1_Intron	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	2					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GTCGCTGAACCATCATGGGAC	0.507													31	32					0	0	0.00178596	0	0
CER1	9350	broad.mit.edu	37	9	14722582	14722582	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:14722582A>T	uc003zlj.2	-	1	134	c.89T>A	c.(88-90)CTT>CAT	p.L30H		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	30					BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		TACGGGGGAAAGAGAACTCTG	0.547													18	42					0	0	0.00121646	0	0
ACER2	340485	broad.mit.edu	37	9	19435068	19435068	+	Silent	SNP	C	T	T	rs141700425	byFrequency	TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:19435068C>T	uc003zny.1	+	4	647	c.489C>T	c.(487-489)ATC>ATT	p.I163I	ACER2_uc003znx.1_RNA|ACER2_uc003znz.1_Silent_p.I114I	NM_001010887	NP_001010887	Q5QJU3	ACER2_HUMAN	alkaline ceramidase 2	163	Helical; (Potential).				ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2						CACTGCTCATCGCAGAGCTAA	0.552													16	27					0	0	0.000566183	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627368	43627368	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:43627368A>G	uc011lrb.1	-	4	1348	c.1319T>C	c.(1318-1320)TTA>TCA	p.L440S		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	440						integral to membrane					0						AGGAGACTGTAAAGTATAAGA	0.502													92	151					0	0	0.000781405	0	0
Unknown	0	broad.mit.edu	37	9	68414259	68414259	+	RNA	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:68414259C>T	uc004aex.2	+	1		c.814C>T								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		ccacagtggcctcaaagaact	0.254													3	1					0	0	6.4e-05	0	0
PRKACG	5568	broad.mit.edu	37	9	71628516	71628516	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:71628516G>A	uc004agy.2	-	1	524	c.493C>T	c.(493-495)CAC>TAC	p.H165Y		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	165	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						AGGTCGCGGTGGATGAGGTCG	0.632													7	11					0	0	0.000157383	0	0
FGD3	89846	broad.mit.edu	37	9	95738973	95738973	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:95738973G>A	uc004asw.2	+	3	1063	c.435G>A	c.(433-435)AAG>AAA	p.K145K	FGD3_uc004asx.2_Silent_p.K145K|FGD3_uc004asz.2_Silent_p.K145K	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	145					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						AGGCTGACAAGGATGCCGGCC	0.642													12	26					0	0	0.00136819	0	0
CYLC2	1539	broad.mit.edu	37	9	105765445	105765445	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:105765445C>T	uc004bbs.2	+	3	150	c.80C>T	c.(79-81)TCA>TTA	p.S27L		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	27	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				AGCAAAAAATCATGGAATCAG	0.398													12	57					0	0	0.00136819	0	0
MUSK	4593	broad.mit.edu	37	9	113431248	113431248	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:113431248G>A	uc004bey.2	+	1	162	c.64G>A	c.(64-66)GAG>AAG	p.E22K	MUSK_uc004bex.2_Missense_Mutation_p.E22K	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	22					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						CAGCGGAACTGAGAAACTTCC	0.423													28	151					0	0	0.00127121	0	0
OR1L8	138881	broad.mit.edu	37	9	125329868	125329868	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:125329868G>A	uc004bmp.1	-	1	889	c.889C>T	c.(889-891)CTG>TTG	p.L297L		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3						CCCTGTTTCAGGTCTTTGTTT	0.458													39	52					0	0	0.00170553	0	0
OR1L8	138881	broad.mit.edu	37	9	125330013	125330013	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:125330013C>T	uc004bmp.1	-	1	744	c.744G>A	c.(742-744)GTG>GTA	p.V248V		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3						AGAGCGTCACCACGGTGAGGT	0.453													23	18					0	0	0.00188189	0	0
LRRC8A	56262	broad.mit.edu	37	9	131671262	131671262	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:131671262C>T	uc004bwl.3	+	3	2073	c.1819C>T	c.(1819-1821)CCC>TCC	p.P607S	LRRC8A_uc010myp.2_Missense_Mutation_p.P607S|LRRC8A_uc010myq.2_Missense_Mutation_p.P607S	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	607	LRR 10.				pre-B cell differentiation	integral to membrane					0						GGAGCGCATCCCCCACTCCAT	0.557													12	48					0	0	0.00136819	0	0
EXOSC2	23404	broad.mit.edu	37	9	133578458	133578458	+	Nonsense_Mutation	SNP	C	T	T	rs149299789	by1000genomes	TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:133578458C>T	uc004bzu.2	+	8	712	c.691C>T	c.(691-693)CGA>TGA	p.R231*	EXOSC2_uc011mbz.1_Nonsense_Mutation_p.R205*|EXOSC2_uc011mca.1_RNA	NM_014285	NP_055100	Q13868	EXOS2_HUMAN	exosome component 2	231					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|positive regulation of cell growth|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|7S RNA binding|protein binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(13;0.0588)		OV - Ovarian serous cystadenocarcinoma(145;0.000324)		TCTTGCTGATCGAGAGGTGAT	0.468													21	114					0	0	0.00278032	0	0
SETX	23064	broad.mit.edu	37	9	135203263	135203263	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:135203263G>T	uc004cbk.2	-	10	3905	c.3722C>A	c.(3721-3723)ACC>AAC	p.T1241N	SETX_uc004cbj.2_Missense_Mutation_p.T860N|SETX_uc010mzt.2_Missense_Mutation_p.T860N	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1241					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TTTCTTAGGGGTCTTAGAAAC	0.393													40	98					1.49673e-21	5.54729e-21	0.00128727	1	0
TTF1	7270	broad.mit.edu	37	9	135277771	135277771	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:135277771C>T	uc004cbl.2	-	2	490	c.438G>A	c.(436-438)CAG>CAA	p.Q146Q	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	146	N-terminal region (NRD) (By similarity).				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		TAGCAAGTACCTGAAATTTGT	0.383													41	73					0	0	0.00128727	0	0
COL5A1	1289	broad.mit.edu	37	9	137734038	137734038	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:137734038C>T	uc004cfe.2	+	66	5788	c.5406C>T	c.(5404-5406)ATC>ATT	p.I1802I	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1802	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TTCTGGAGATCGACACCCCCA	0.532													9	43					0	0	0.000274275	0	0
PRKX	5613	broad.mit.edu	37	X	3530319	3530319	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:3530319G>A	uc010nde.2	-	8	1366	c.999C>T	c.(997-999)TTC>TTT	p.F333F		NM_005044	NP_005035	P51817	PRKX_HUMAN	protein kinase, X-linked	333	AGC-kinase C-terminal.						ATP binding|cAMP-dependent protein kinase activity			skin(2)|lung(1)	3		all_lung(23;0.000396)|Lung NSC(23;0.00123)				GGTAAGTTTCGAAGTTGGAAG	0.527													14	29					0	0	0.000308642	0	0
SCML2	10389	broad.mit.edu	37	X	18264805	18264805	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:18264805C>T	uc004cyl.2	-	13	1871	c.1714G>A	c.(1714-1716)GAT>AAT	p.D572N	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.D572N|SCML2_uc011miz.1_Missense_Mutation_p.D506N|SCML2_uc010nfc.2_Missense_Mutation_p.D308N	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	572					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					CGAGAAAAATCCTGGGAGACT	0.413													39	91					0	0	0.00148497	0	0
DMD	1756	broad.mit.edu	37	X	32235169	32235169	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:32235169C>T	uc004dda.1	-	44	6546	c.6302G>A	c.(6301-6303)AGA>AAA	p.R2101K	DMD_uc004dcw.2_Missense_Mutation_p.R757K|DMD_uc004dcx.2_Missense_Mutation_p.R760K|DMD_uc004dcz.2_Missense_Mutation_p.R1978K|DMD_uc004dcy.1_Missense_Mutation_p.R2097K|DMD_uc004ddb.1_Missense_Mutation_p.R2093K|DMD_uc010ngo.1_Missense_Mutation_p.R10K|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2101	Spectrin 14.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTCAACAGATCTGTCAAATCG	0.338													4	23					0	0	0.000602214	0	0
DMD	1756	broad.mit.edu	37	X	32328381	32328381	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:32328381C>T	uc004dda.1	-	42	6179	c.5935G>A	c.(5935-5937)GAA>AAA	p.E1979K	DMD_uc004dcw.2_Missense_Mutation_p.E635K|DMD_uc004dcx.2_Missense_Mutation_p.E638K|DMD_uc004dcz.2_Missense_Mutation_p.E1856K|DMD_uc004dcy.1_Missense_Mutation_p.E1975K|DMD_uc004ddb.1_Missense_Mutation_p.E1971K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1979	Spectrin 13.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATCGTTTCTTCACGGACAGTG	0.368													4	17					0	0	0.00024832	0	0
FAM47B	170062	broad.mit.edu	37	X	34961617	34961617	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:34961617C>T	uc004ddi.1	+	1	687	c.669C>T	c.(667-669)CTC>CTT	p.L223L		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	223	Pro-rich.									ovary(3)|breast(1)	4						TGTCCAGTCTCCGCCCAGAGC	0.657													21	40					0	0	0.00047179	0	0
SLC9A7	84679	broad.mit.edu	37	X	46532037	46532037	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:46532037G>A	uc004dgu.1	-	4	637	c.629C>T	c.(628-630)TCT>TTT	p.S210F	SLC9A7_uc004dgv.1_Missense_Mutation_p.S210F	NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	210					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						GGCCAGTATAGATCCAAGATT	0.358													34	88					0	0	0.00128727	0	0
CDK16	5127	broad.mit.edu	37	X	47083085	47083085	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:47083085C>T	uc004dho.2	+	2	525	c.129C>T	c.(127-129)GAC>GAT	p.D43D	CDK16_uc011mli.1_Silent_p.D49D|CDK16_uc011mlj.1_Silent_p.D43D|CDK16_uc011mlk.1_Silent_p.D43D|CDK16_uc011mll.1_Silent_p.D117D	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	43							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						GCGGCAGTGACCCTGGAGAGG	0.632													9	19					0	0	0.000442599	0	0
CACNA1F	778	broad.mit.edu	37	X	49069183	49069183	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:49069183G>A	uc004dnb.2	-	33	3981	c.3919C>T	c.(3919-3921)CTC>TTC	p.L1307F	CACNA1F_uc010nip.2_Missense_Mutation_p.L1296F	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1307	Helical; Name=S4 of repeat IV; (Potential).|IV.				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CCCTTACTGAGAAGCTTGACC	0.542													15	24					0	0	0.000422831	0	0
CLCN5	1184	broad.mit.edu	37	X	49855487	49855487	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:49855487C>T	uc004dos.1	+	11	2342	c.2094C>T	c.(2092-2094)ATC>ATT	p.I698I	CLCN5_uc004dor.1_Silent_p.I768I|CLCN5_uc004doq.1_Silent_p.I768I|CLCN5_uc004dot.1_Silent_p.I698I	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	698	CBS 2.|Cytoplasmic (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					CCATGGAGATCGTAGTGGATA	0.488													21	45					0	0	0.00229938	0	0
HUWE1	10075	broad.mit.edu	37	X	53654416	53654416	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:53654416C>T	uc004dsp.2	-	17	1836	c.1434G>A	c.(1432-1434)AAG>AAA	p.K478K		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	478					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GTCTCTGGATCTTTGGCTTGA	0.323													46	102					0	0	0.000781405	0	0
TSR2	90121	broad.mit.edu	37	X	54470860	54470860	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:54470860G>A	uc004dte.2	+	5	455	c.453G>A	c.(451-453)ACG>ACA	p.T151T	TSR2_uc004dtf.2_Silent_p.T56T	NM_058163	NP_477511	Q969E8	TSR2_HUMAN	TSR2, 20S rRNA accumulation, homolog	151					rRNA processing		protein binding				0						TCACAGCTACGAATGATGGGG	0.363													11	16					0	0	0.000978159	0	0
ZMYM3	9203	broad.mit.edu	37	X	70464712	70464712	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:70464712G>A	uc004dzh.1	-	19	3126	c.3039C>T	c.(3037-3039)TTC>TTT	p.F1013F	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.F1013F|ZMYM3_uc004dzj.1_Silent_p.F1001F	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1013					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					AATCAAAGAGGAAGTCTACAC	0.478													16	39					0	0	0.00121646	0	0
HDAC8	55869	broad.mit.edu	37	X	71684536	71684536	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:71684536G>A	uc004eau.2	-	8	825	c.783C>T	c.(781-783)GTC>GTT	p.V261V	HDAC8_uc011mqe.1_Silent_p.V118V|HDAC8_uc011mqf.1_Silent_p.V66V|HDAC8_uc011mqg.1_Silent_p.V170V|HDAC8_uc011mqh.1_Silent_p.V170V|HDAC8_uc010nlk.1_Silent_p.V132V	NM_018486	NP_060956	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	261	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding				0	Renal(35;0.156)				Vorinostat(DB02546)	CCAGCTGTAAGACCACTGCTT	0.428													24	48					0	0	0.000878237	0	0
PGK1	5230	broad.mit.edu	37	X	77369647	77369647	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:77369647C>T	uc004ecz.3	+	4	579	c.407C>T	c.(406-408)TCT>TTT	p.S136F	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_Missense_Mutation_p.S108F	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	136					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						AAAGATGCTTCTGGGAACAAG	0.483													148	252					0	0	0.000781405	0	0
HDX	139324	broad.mit.edu	37	X	83599324	83599324	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:83599324C>T	uc004eek.1	-	6	1703	c.1594G>A	c.(1594-1596)GAA>AAA	p.E532K	HDX_uc011mqv.1_Missense_Mutation_p.E532K|HDX_uc004eel.1_Missense_Mutation_p.E474K	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	532						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCTCCTACTTCAGGCCCAGCT	0.453													9	25					0	0	0.000978159	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177429	89177429	+	Silent	SNP	G	A	A	rs138727889	byFrequency	TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:89177429G>A	uc004efe.2	+	2	394	c.345G>A	c.(343-345)CAG>CAA	p.Q115Q		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	115						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						TGCTTCAACAGCGTAGAAACG	0.522													47	65					0	0	0.000781405	0	0
LOC442459	442459	broad.mit.edu	37	X	98975264	98975264	+	RNA	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:98975264C>T	uc011mrd.1	-	8		c.1079G>A				NR_024608				Homo sapiens DNA repair protein mRNA, complete cds.												0						TATTAAATTTCCGGGACTTGG	0.433													22	32					0	0	0.000586117	0	0
SRPX2	27286	broad.mit.edu	37	X	99921834	99921834	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:99921834G>A	uc004egb.2	+	8	1345	c.865G>A	c.(865-867)GAA>AAA	p.E289K		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	289	Sushi 3.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						TGCCACCTGTGAATACCACTG	0.607													32	54					0	0	0.00283554	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106064139	106064139	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:106064139G>A	uc004emo.2	+	3	439	c.274G>A	c.(274-276)GAT>AAT	p.D92N	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emm.2_Missense_Mutation_p.D92N|TBC1D8B_uc004emn.2_Missense_Mutation_p.D92N	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	92						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CAAGCATTGGGATTGGTTGGA	0.308													21	65					0	0	0.00229938	0	0
DOCK11	139818	broad.mit.edu	37	X	117814593	117814593	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:117814593C>T	uc004eqp.2	+	49	5672	c.5609C>T	c.(5608-5610)ACT>ATT	p.T1870I	DOCK11_uc004eqq.2_Missense_Mutation_p.T1649I	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1870	DHR-2.				blood coagulation	cytosol	GTP binding			ovary(3)	3						GCCCCTTACACTTTATCAGGC	0.353													66	146					0	0	0.000781405	0	0
SEPT6	23157	broad.mit.edu	37	X	118783980	118783980	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:118783980C>T	uc004erv.2	-	5	875	c.610G>A	c.(610-612)GAG>AAG	p.E204K	SEPT6_uc010nqk.2_RNA|SEPT6_uc004ers.2_Missense_Mutation_p.E204K|SEPT6_uc004ert.2_Missense_Mutation_p.E204K|SEPT6_uc004eru.2_Missense_Mutation_p.E204K|SEPT6_uc004erw.2_Missense_Mutation_p.E146K|SEPT6_uc011mtv.1_Missense_Mutation_p.E146K|SEPT6_uc011mtw.1_Missense_Mutation_p.E234K	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	204					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4						CTGACAAGCTCGCTGGTGATT	0.473													65	144					0	0	0.000781405	0	0
UPF3B	65109	broad.mit.edu	37	X	118979221	118979221	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:118979221G>C	uc004erz.1	-	4	486	c.409C>G	c.(409-411)CAA>GAA	p.Q137E	UPF3B_uc004esa.1_Missense_Mutation_p.Q137E	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	137	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						GCAGCTTTTTGAAAAGGTGCA	0.348													41	81					0	0	0.00222228	0	0
ODZ1	10178	broad.mit.edu	37	X	123517893	123517893	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:123517893C>T	uc004euj.2	-	29	6931	c.6867G>A	c.(6865-6867)TCG>TCA	p.S2289S	ODZ1_uc011muj.1_Silent_p.S2295S|ODZ1_uc010nqy.2_Silent_p.S2296S	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2289	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						ATGTAATCTCCGAGCTTGTGT	0.443													58	109					0	0	0.000781405	0	0
ENOX2	10495	broad.mit.edu	37	X	129804055	129804055	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:129804055G>A	uc004evw.2	-	8	1083	c.665C>T	c.(664-666)GCC>GTC	p.A222V	ENOX2_uc004evx.2_Missense_Mutation_p.A193V|ENOX2_uc004evy.2_Missense_Mutation_p.A193V|ENOX2_uc004evv.2_Missense_Mutation_p.A49V	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	222					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						CTCCTCTCTGGCTAGCATACG	0.502													26	76					0	0	0.00047179	0	0
GPR112	139378	broad.mit.edu	37	X	135431704	135431704	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:135431704C>T	uc004ezu.1	+	6	6130	c.5839C>T	c.(5839-5841)CCT>TCT	p.P1947S	GPR112_uc010nsb.1_Missense_Mutation_p.P1742S|GPR112_uc010nsc.1_Missense_Mutation_p.P1714S	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1947	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AGGAATTCTTCCTAACCATGG	0.423													25	82					0	0	0.000720815	0	0
CDR1	1038	broad.mit.edu	37	X	139865895	139865895	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:139865895C>T	uc004fbg.1	-	1	829	c.637G>A	c.(637-639)GGA>AGA	p.G213R	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	213											0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCAGTCAATCCACATCTTCCG	0.433													44	83					0	0	0.0025221	0	0
AFF2	2334	broad.mit.edu	37	X	148044401	148044401	+	Silent	SNP	C	T	T			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:148044401C>T	uc004fcp.2	+	13	3326	c.2847C>T	c.(2845-2847)ATC>ATT	p.I949I	AFF2_uc004fcq.2_Silent_p.I939I|AFF2_uc004fcr.2_Silent_p.I910I|AFF2_uc011mxb.1_Silent_p.I914I|AFF2_uc004fcs.2_Silent_p.I916I|AFF2_uc011mxc.1_Silent_p.I590I	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	949					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CTGGACAAATCACATCTACCA	0.433													19	39					0	0	0.00229938	0	0
MAGEA5	4104	broad.mit.edu	37	X	151283959	151283959	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:151283959G>A	uc004ffj.2	-	3	259	c.54C>T	c.(52-54)ACC>ACT	p.T18T		NM_021049	NP_066387	P43359	MAGA5_HUMAN	melanoma antigen family A, 5	18	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCTTCTTGGGTGTCAAGGC	0.632													43	84					0	0	0.000781405	0	0
HCFC1	3054	broad.mit.edu	37	X	153220575	153220575	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:153220575G>A	uc004fjp.2	-	17	3803	c.3275C>T	c.(3274-3276)ACC>ATC	p.T1092I		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1092	HCF repeat 2.			T->A: Inactivates cleavage at HCF repeat.	cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ggtggcggtggtggcggtgtt	0.537													14	22					0	0	0.00244969	0	0
PLXNA3	55558	broad.mit.edu	37	X	153696822	153696822	+	Silent	SNP	G	A	A			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chrX:153696822G>A	uc004flm.2	+	23	4313	c.4140G>A	c.(4138-4140)ACG>ACA	p.T1380T		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1380	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACTATGCCACGGGGCTGCTCA	0.647													13	39					0	0	0.00185496	0	0
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	G	G	rs113730440		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr17:26684394_26684395insG	uc002haz.2	-	2	210	c.78_splice	c.e2+1	p.W26_splice	POLDIP2_uc010wag.1_RNA|TMEM199_uc002hba.2_5'Flank|SARM1_uc010wah.1_5'Flank	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	DNA polymerase delta interacting protein 2							mitochondrial nucleoid|nucleus					0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													6	5	---	---	---	---					
ASXL3	80816	broad.mit.edu	37	18	31323656	31323656	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:31323656delT	uc010dmg.1	+	12	3899	c.3844delT	c.(3844-3846)TTAfs	p.L1282fs	ASXL3_uc002kxq.2_Frame_Shift_Del_p.L989fs	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1282	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TATAAGCATGTTAAAAACCAT	0.393													30	77	---	---	---	---					
ZNF407	55628	broad.mit.edu	37	18	72344370	72344381	+	In_Frame_Del	DEL	AACACAGATGAA	-	-			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr18:72344370_72344381delAACACAGATGAA	uc002llw.2	+	1	1452_1463	c.1395_1406delAACACAGATGAA	c.(1393-1407)AGAACACAGATGAAA>AGA	p.TQMK466del	ZNF407_uc010xfc.1_In_Frame_Del_p.TQMK466del|ZNF407_uc010dqu.1_In_Frame_Del_p.TQMK466del|ZNF407_uc002llu.2_In_Frame_Del_p.TQMK465del	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	466_469					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AACACTTGAGAACACAGATGAAAACACACGAT	0.458													30	50	---	---	---	---					
ADCY3	109	broad.mit.edu	37	2	25141322	25141324	+	In_Frame_Del	DEL	AGG	-	-	rs140278293		TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr2:25141322_25141324delAGG	uc002rfs.3	-	1	732_734	c.533_535delCCT	c.(532-537)TCCTTC>TTC	p.S178del	ADCY3_uc010ykm.1_In_Frame_Del_p.S178del	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	178	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GTGATGAAGAAGGAGAAGACAAA	0.616													17	23	---	---	---	---					
CCDC28A	25901	broad.mit.edu	37	6	139097330	139097330	+	Frame_Shift_Del	DEL	A	-	-			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:139097330delA	uc003qie.2	+	2	498	c.343delA	c.(343-345)AAAfs	p.K115fs	uc003qid.1_5'Flank	NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	115											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TGTCAATGCCAAAAAAAATGC	0.413													7	103	---	---	---	---					
REPS1	85021	broad.mit.edu	37	6	139235874	139235887	+	Frame_Shift_Del	DEL	GCAACAACTCCAGC	-	-			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr6:139235874_139235887delGCAACAACTCCAGC	uc003qii.2	-	15	2311_2324	c.1732_1745delGCTGGAGTTGTTGC	c.(1732-1746)GCTGGAGTTGTTGCCfs	p.A578fs	REPS1_uc003qig.3_Frame_Shift_Del_p.A551fs|REPS1_uc011edr.1_Frame_Shift_Del_p.A577fs|REPS1_uc003qij.2_Frame_Shift_Del_p.A487fs|REPS1_uc003qik.2_Frame_Shift_Del_p.A184fs	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	578_582	Pro-rich.					coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		AGGAGGATGGGCAACAACTCCAGCCTGTTGTTGT	0.397													7	65	---	---	---	---					
KIAA1429	25962	broad.mit.edu	37	8	95503845	95503845	+	Frame_Shift_Del	DEL	G	-	-			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr8:95503845delG	uc003ygo.1	-	22	5114	c.5101delC	c.(5101-5103)CACfs	p.H1701fs	KIAA1429_uc010maz.1_Intron	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1701					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTCTGACTGTGGAAAGCACCC	0.398													27	75	---	---	---	---					
GRIN3A	116443	broad.mit.edu	37	9	104432476	104432477	+	Frame_Shift_Ins	INS	-	ACAT	ACAT			TCGA-DA-A1HW-06A-11D-A19A-08	TCGA-DA-A1HW-10A-01D-A19A-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc249113-83d4-4abe-8c80-a4f7305dcd91	33f2b633-1489-4934-a556-19cc41fc0841	g.chr9:104432476_104432477insACAT	uc004bbp.1	-	3	2818_2819	c.2217_2218insATGT	c.(2215-2220)TGTTGGfs	p.C739fs	GRIN3A_uc004bbq.1_Frame_Shift_Ins_p.C739fs	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	739_740	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CTTCCAGTCCAACATTTTGGAG	0.441													11	38	---	---	---	---					
