Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NSUN4	387338	broad.mit.edu	37	1	46818685	46818685	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr1:46818685G>A	uc001cpr.1	+	4	847	c.738G>A	c.(736-738)GGG>GGA	p.G246G	NSUN4_uc010omc.1_Silent_p.G197G|NSUN4_uc009vyf.1_Silent_p.G95G|NSUN4_uc009vyg.1_Silent_p.G197G|NSUN4_uc001cpt.1_RNA|NSUN4_uc001cps.1_RNA	NM_199044	NP_950245	Q96CB9	NSUN4_HUMAN	NOL1/NOP2/Sun domain family 4 protein	246							methyltransferase activity				0	Acute lymphoblastic leukemia(166;0.155)					AACTGGAGGGGGACACCTATG	0.517000													5	48					0	0	8.12818e-05	0	0
HMGCS2	3158	broad.mit.edu	37	1	120307194	120307194	+	Missense_Mutation	SNP	C	T	T	rs28937320		TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr1:120307194C>T	uc001eid.2	-	2	211	c.160G>A	c.(160-162)GTG>ATG	p.V54M	HMGCS2_uc010oxj.1_Missense_Mutation_p.V54M|HMGCS2_uc001eie.2_Translation_Start_Site	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	54					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		AGGATGCCCACGTCCTTTGGC	0.502000													58	262					0	0	0.000147903	0	0
TCHH	7062	broad.mit.edu	37	1	152080821	152080821	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr1:152080821G>C	uc001ezp.2	-	2	4872	c.4872C>G	c.(4870-4872)GAC>GAG	p.D1624E	TCHH_uc009wne.1_Missense_Mutation_p.D1624E	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1624	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCAGCTGTTCGTCTTCGCGGA	0.597000													3	123					0	0	6.4e-05	0	0
SPTA1	6708	broad.mit.edu	37	1	158614069	158614069	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr1:158614069C>T	uc001fst.1	-	30	4511	c.4312G>A	c.(4312-4314)GAT>AAT	p.D1438N		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1438	Spectrin 14.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTGTCCAAATCGTCCCGTTTC	0.353000													11	94					0	0	0.000151284	0	0
CACNA1E	777	broad.mit.edu	37	1	181453097	181453098	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr1:181453097_181453098GG>TT	uc001gow.2	+	1	382_383	c.217_218GG>TT	c.(217-219)GGA>TTA	p.G73L		NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	73	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GTTCATCTTCGGAGAAGATAAC	0.505000													9	307					0	0	6.4e-05	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232629308	232629309	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr1:232629308_232629309GG>TT	uc001hvg.2	-	2	1739_1740	c.1581_1582CC>AA	c.(1579-1584)TCCCAG>TCAAAG	p.Q528K		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	528					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TAGTTGAACTGGGATCCTTCTT	0.470000													16	443					0	0	6.4e-05	0	0
OR2T35	403244	broad.mit.edu	37	1	248801912	248801912	+	Silent	SNP	C	G	G	rs146851066	by1000genomes	TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr1:248801912C>G	uc001ies.1	-	1	648	c.648G>C	c.(646-648)GTG>GTC	p.V216V		NM_001001827	NP_001001827	Q8NGX2	O2T35_HUMAN	olfactory receptor, family 2, subfamily T,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;2.04e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCGTGTAGGACACAGAGATGA	0.542000													4	9					0	0	0.00024832	0	0
SVIL	6840	broad.mit.edu	37	10	29769471	29769471	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr10:29769471G>A	uc001iut.1	-	29	6125	c.5372C>T	c.(5371-5373)ACG>ATG	p.T1791M	LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Missense_Mutation_p.T705M|SVIL_uc001iuu.1_Missense_Mutation_p.T1365M|SVIL_uc009xlc.2_Missense_Mutation_p.T583M	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1791	Gelsolin-like 3.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CTAACCTGCCGTGCTCACCAT	0.562000													15	48					0	0	0.000175454	0	0
EXOC6	54536	broad.mit.edu	37	10	94708065	94708066	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr10:94708065_94708066CC>AA	uc001kig.2	+	14	1411_1412	c.1345_1346CC>AA	c.(1345-1347)CCT>AAT	p.P449N	EXOC6_uc010qnr.1_Missense_Mutation_p.P465N|EXOC6_uc001kie.2_Missense_Mutation_p.P444N|EXOC6_uc009xub.2_Missense_Mutation_p.P449N|EXOC6_uc009xuc.2_Missense_Mutation_p.P346N|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Missense_Mutation_p.P23N	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	449					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				CAGCCCCATCCCTGTTGTCAAT	0.312000													10	226					0	0	6.4e-05	0	0
OR52N1	79473	broad.mit.edu	37	11	5809489	5809489	+	Silent	SNP	C	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr11:5809489C>A	uc010qzo.1	-	1	558	c.558G>T	c.(556-558)GTG>GTT	p.V186V	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ATATCTTGGCCACAGACATGT	0.493000													22	23					5.26018e-13	1.64137e-11	0.000229342	1	0
MRGPRX4	117196	broad.mit.edu	37	11	18195349	18195349	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr11:18195349G>A	uc001mnv.1	+	1	966	c.546G>A	c.(544-546)GCG>GCA	p.A182A		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	182	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						TCCCAGTCGCGTGGCTGATTT	0.512000													21	101					0	0	0.000229342	0	0
LOC441601	441601	broad.mit.edu	37	11	50252746	50252746	+	RNA	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr11:50252746G>A	uc001nhd.2	-	3		c.440C>T				NR_003034				Homo sapiens septin 7 pseudogene, transcript variant 2, mRNA (cDNA clone IMAGE:5265802).												0						GTTCACGCATGATTCTGCATT	0.388000													7	41					0	0	8.12818e-05	0	0
ASAM	79827	broad.mit.edu	37	11	122953836	122953836	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr11:122953836G>A	uc001pyt.2	-	5	995	c.636C>T	c.(634-636)AAC>AAT	p.N212N		NM_024769	NP_079045	Q9H6B4	CLMP_HUMAN	adipocyte-specific adhesion molecule precursor	212	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Breast(109;0.0025)|Lung NSC(97;0.0179)|all_lung(97;0.0182)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.73e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		TCCCAGCTTCGTTGCCTGCTG	0.453000													8	64					0	0	0.000442599	0	0
HEPACAM	220296	broad.mit.edu	37	11	124792340	124792340	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr11:124792340G>A	uc001qbk.2	-	6	1298	c.892C>T	c.(892-894)CGA>TGA	p.R298*	HEPACAM_uc009zbj.2_Nonsense_Mutation_p.R16*	NM_152722	NP_689935	Q14CZ8	HECAM_HUMAN	hepatocyte cell adhesion molecule precursor	298	Cytoplasmic (Potential).				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TCACCACTTCGAGGGAGGGTG	0.607000													25	91					0	0	9.22233e-05	0	0
ETS1	2113	broad.mit.edu	37	11	128426240	128426240	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr11:128426240A>C	uc001qej.2	-	3	245	c.160T>G	c.(160-162)TGG>GGG	p.W54G		NM_001143820	NP_001137292	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		ATCTCATCCCAAAAGGGGTAG	0.458000													3	72					0	0	6.4e-05	0	0
DDX12	440081	broad.mit.edu	37	12	9580280	9580280	+	Silent	SNP	A	G	G	rs146037854	by1000genomes	TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr12:9580280A>G	uc010sgs.1	-	14	1626	c.1431T>C	c.(1429-1431)ACT>ACC	p.T477T		NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						AGTCGTTGATAGTCTTCAGCT	0.493000													3	37					0	0	3.59834e-05	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717349	13717349	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr12:13717349G>A	uc001rbt.2	-	13	3002	c.2823C>T	c.(2821-2823)TTC>TTT	p.F941F		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	941	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CAGAATGCGTGAAGCTGCGGC	0.557000													20	113					0	0	0.000229342	0	0
OR6C4	341418	broad.mit.edu	37	12	55945074	55945074	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr12:55945074C>A	uc010spp.1	+	1	64	c.64C>A	c.(64-66)CAA>AAA	p.Q22K		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACCTGAACTCCAAGTGATGAT	0.418000													18	87					5.3912e-06	0.000152675	7.07596e-05	1	0
RPH3A	22895	broad.mit.edu	37	12	113285499	113285499	+	Splice_Site	SNP	A	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr12:113285499A>G	uc010syl.1	+	5	446	c.84_splice	c.e5-2	p.Q28_splice	RPH3A_uc001ttz.2_Splice_Site_p.Q28_splice|RPH3A_uc001tty.2_Splice_Site_p.K24_splice|RPH3A_uc009zwe.1_Splice_Site_p.K24_splice|RPH3A_uc010sym.1_Intron	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1						intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		ATTTCCTTTCAGGCTCCAGGC	0.388000													3	62					0	0	6.4e-05	0	0
SIRT4	23409	broad.mit.edu	37	12	120750786	120750786	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr12:120750786C>A	uc001tyc.2	+	4	912	c.892C>A	c.(892-894)CTG>ATG	p.L298M		NM_012240	NP_036372	Q9Y6E7	SIRT4_HUMAN	sirtuin 4	298	Deacetylase sirtuin-type.				chromatin silencing|negative regulation of insulin secretion|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTTGGCGTGTCTGAAACTGAA	0.493000													28	88					7.01153e-11	2.12873e-09	0.000184323	1	0
P2RX7	5027	broad.mit.edu	37	12	121593937	121593937	+	Missense_Mutation	SNP	G	A	A	rs146441492	byFrequency	TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr12:121593937G>A	uc001tzm.2	+	3	446	c.350G>A	c.(349-351)CGG>CAG	p.R117Q	P2RX7_uc001tzn.2_Missense_Mutation_p.R27Q|P2RX7_uc001tzo.2_RNA|P2RX7_uc001tzp.2_5'UTR|P2RX7_uc001tzq.2_5'UTR	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	117						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAAGAGCAGCGGTTGTGTCCC	0.522000													54	301					0	0	0.000147903	0	0
KIAA0564	23078	broad.mit.edu	37	13	42266012	42266012	+	Silent	SNP	T	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr13:42266012T>C	uc001uyj.2	-	31	3808	c.3738A>G	c.(3736-3738)AAA>AAG	p.K1246K		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1246						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		GAGCTCACCCTTTTTCTTTGT	0.289000													3	113					0	0	0.00024832	0	0
RNASE3	6037	broad.mit.edu	37	14	21360234	21360234	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr14:21360234G>A	uc001vyj.2	+	2	443	c.389G>A	c.(388-390)GGA>GAA	p.G130E		NM_002935	NP_002926	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3 (eosinophil	130					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	GACAGACCAGGAAGGAGGTTC	0.478000													33	27					0	0	0.000491102	0	0
TGFB3	7043	broad.mit.edu	37	14	76437468	76437468	+	Splice_Site	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr14:76437468C>T	uc001xsc.2	-	3	1502	c.646_splice	c.e3+1	p.E216_splice	TGFB3_uc001xsd.2_Splice_Site_p.E214_splice	NM_003239	NP_003230	P10600	TGFB3_HUMAN	transforming growth factor, beta 3 precursor						cell growth|cell-cell junction organization|detection of hypoxia|face morphogenesis|in utero embryonic development|induction of apoptosis|lung alveolus development|mammary gland development|menstrual cycle phase|negative regulation of cell proliferation|negative regulation of DNA replication|negative regulation of macrophage cytokine production|negative regulation of neuron apoptosis|odontogenesis|ossification involved in bone remodeling|palate development|platelet activation|platelet degranulation|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of collagen biosynthetic process|positive regulation of DNA replication|positive regulation of epithelial to mesenchymal transition|positive regulation of filopodium assembly|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|response to progesterone stimulus|salivary gland morphogenesis|transforming growth factor beta receptor signaling pathway	extracellular matrix|platelet alpha granule lumen	growth factor activity|identical protein binding|transforming growth factor beta binding|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0169)		GGTCCACCTACCTCTTCTCAA	0.438000													14	77					0	0	0.000308642	0	0
HERC2	8924	broad.mit.edu	37	15	28386694	28386694	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr15:28386694C>G	uc001zbj.2	-	78	12005	c.11899G>C	c.(11899-11901)GGC>CGC	p.G3967R		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3967	WD 5.|RCC1 13.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CCTTCAATGCCCCCGAGCTGG	0.527000													22	92					0	0	0.000295444	0	0
C15orf54	400360	broad.mit.edu	37	15	39544862	39544862	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr15:39544862A>G	uc001zkg.2	+	2	894	c.526A>G	c.(526-528)ATG>GTG	p.M176V		NM_207445	NP_997328	Q8N8G6	CO054_HUMAN	hypothetical protein LOC400360	176											0		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		GTTCAATGTCATGGCTGTAAG	0.468000													7	57					0	0	0.000157383	0	0
MGA	23269	broad.mit.edu	37	15	42041031	42041031	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr15:42041031C>T	uc010ucy.1	+	16	5590	c.5409C>T	c.(5407-5409)CAC>CAT	p.H1803H	MGA_uc010ucz.1_Silent_p.H1594H|MGA_uc010uda.1_Silent_p.H419H|MGA_uc001zoi.2_Silent_p.H17H	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1764						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TATTCAGGCACCCTAATGGGC	0.483000													14	60					0	0	0.000151284	0	0
ANPEP	290	broad.mit.edu	37	15	90347174	90347174	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr15:90347174G>A	uc002bop.3	-	7	1531	c.1239C>T	c.(1237-1239)TTC>TTT	p.F413F		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	413	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CGTAGGAGGCGAAGCCCTCGT	0.642000													14	23					0	0	7.07596e-05	0	0
PRSS27	83886	broad.mit.edu	37	16	2763567	2763567	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr16:2763567C>T	uc002crf.2	-	5	1032	c.641G>A	c.(640-642)TGC>TAC	p.C214Y	PRSS27_uc002cre.2_Missense_Mutation_p.C178Y|PRSS27_uc002crg.2_Missense_Mutation_p.C112Y|PRSS27_uc010bst.1_Missense_Mutation_p.C112Y	NM_031948	NP_114154	Q9BQR3	PRS27_HUMAN	marapsin precursor	214	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						GAAGCCGGCGCACAGCATGTC	0.592000													16	89					0	0	0.000175454	0	0
SETD1A	9739	broad.mit.edu	37	16	30975994	30975994	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr16:30975994C>T	uc002ead.1	+	7	1617	c.931C>T	c.(931-933)CGC>TGC	p.R311C		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	311	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						TGCCTTTTCCCGCCGCCACTT	0.522000													16	93					0	0	0.000566183	0	0
ZNF423	23090	broad.mit.edu	37	16	49672451	49672451	+	Silent	SNP	G	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr16:49672451G>T	uc002efs.2	-	5	910	c.612C>A	c.(610-612)TCC>TCA	p.S204S	ZNF423_uc010vgn.1_Silent_p.S87S	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	204	C2H2-type 4.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GGTCGCTGCGGGAGAAGGCTG	0.612000													12	35					0.000151284	0.00424857	0.000151284	1	0
TSNAXIP1	55815	broad.mit.edu	37	16	67859130	67859130	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr16:67859130G>A	uc002euj.2	+	7	1001	c.607G>A	c.(607-609)GAG>AAG	p.E203K	TSNAXIP1_uc010cep.2_Missense_Mutation_p.E67K|TSNAXIP1_uc010vjz.1_Missense_Mutation_p.E80K|TSNAXIP1_uc002euf.3_5'UTR|TSNAXIP1_uc010vka.1_Missense_Mutation_p.E257K|TSNAXIP1_uc010vkb.1_Missense_Mutation_p.E188K|TSNAXIP1_uc002eug.3_5'UTR|TSNAXIP1_uc002euh.3_5'UTR|TSNAXIP1_uc002eui.3_5'UTR|TSNAXIP1_uc002euk.2_5'UTR	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	203					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		AGACCTGAATGAGCTGCGGTA	0.532000													8	73					0	0	0.000442599	0	0
ZFHX3	463	broad.mit.edu	37	16	72821615	72821615	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr16:72821615G>A	uc002fck.2	-	10	11233	c.10560C>T	c.(10558-10560)GGC>GGT	p.G3520G	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Silent_p.G2606G	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3520	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				cgccgccgccgccaccgccgc	0.408000													5	20					0	0	0.000602214	0	0
TCF25	22980	broad.mit.edu	37	16	89964996	89964996	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr16:89964996A>G	uc002fpb.2	+	10	1136	c.1054A>G	c.(1054-1056)AGC>GGC	p.S352G	TCF25_uc002fpc.2_Missense_Mutation_p.S117G	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	352					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		CAAGCAGATGAGCTTCCTGGA	0.577000													3	127					0	0	0.00024832	0	0
OR1A2	26189	broad.mit.edu	37	17	3100984	3100984	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr17:3100984C>A	uc002fvd.1	+	1	172	c.172C>A	c.(172-174)CCC>ACC	p.P58T		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CCTTCACAACCCCATGTATTT	0.458000													27	229					2.80507e-11	8.59372e-10	0.000409698	1	0
OR1E2	8388	broad.mit.edu	37	17	3337014	3337014	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr17:3337014C>T	uc010vre.1	-	1	122	c.122G>A	c.(121-123)GGG>GAG	p.G41E		NM_003554	NP_003545	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			large_intestine(1)	1						GAGGAGGTTCCCCAGGAGGGT	0.527000													26	49					0	0	0.000191422	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254013	39254013	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr17:39254013G>C	uc010wfo.1	-	1	363	c.324C>G	c.(322-324)AGC>AGG	p.S108R		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	108	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].|17.					keratin filament					0						gcttgcagcagctggacacac	0.179000													3	29					0	0	0.00024832	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43555412	43555412	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr17:43555412C>T	uc002ija.2	-	3	320	c.150G>A	c.(148-150)ATG>ATA	p.M50I	PLEKHM1_uc010wjm.1_Intron|PLEKHM1_uc002ijb.2_Translation_Start_Site|PLEKHM1_uc010wjn.1_Intron|hsa-mir-4315-1|MI0015844_5'Flank|PLEKHM1_uc002ijd.1_Missense_Mutation_p.M50I	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	50	RUN.				intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					GGGCGCTGCACATGGTGTTGG	0.567000													12	32					0	0	0.00010058	0	0
HEATR6	63897	broad.mit.edu	37	17	58144970	58144970	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr17:58144970C>T	uc002iyk.1	-	8	1080	c.1063G>A	c.(1063-1065)GAA>AAA	p.E355K	HEATR6_uc010ddk.1_5'Flank|HEATR6_uc010wos.1_Missense_Mutation_p.E187K	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	355							binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			GTGTTCCCTTCATGCAGGTTC	0.507000													6	36					0	0	3.59834e-05	0	0
MYOM1	8736	broad.mit.edu	37	18	3116374	3116374	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr18:3116374C>T	uc002klp.2	-	21	3592	c.3258G>A	c.(3256-3258)CAG>CAA	p.Q1086Q	MYOM1_uc002klq.2_Silent_p.Q990Q	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1086	Fibronectin type-III 5.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GCCCTCGCCACTGGTCTTCTT	0.527000													8	23					0	0	0.000442599	0	0
MAN2B1	4125	broad.mit.edu	37	19	12767424	12767424	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:12767424G>A	uc002mub.2	-	13	1681	c.1605C>T	c.(1603-1605)TTC>TTT	p.F535F	MAN2B1_uc010dyv.1_Silent_p.F534F	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	535					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						CCTTCACAACGAAAACGCCTT	0.587000													13	62					0	0	0.00010058	0	0
ZNF333	84449	broad.mit.edu	37	19	14806397	14806397	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:14806397C>T	uc002mzn.2	+	4	281	c.147C>T	c.(145-147)CCC>CCT	p.P49P	ZNF333_uc010dzq.2_Silent_p.P49P|ZNF333_uc002mzk.3_5'UTR|ZNF333_uc002mzl.3_Silent_p.P49P|ZNF333_uc002mzm.2_Intron|ZNF333_uc010dzr.1_RNA	NM_032433	NP_115809	Q96JL9	ZN333_HUMAN	zinc finger protein 333	49	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CATGCAAACCCAGTTGTGTCT	0.527000													11	29					0	0	6.40141e-05	0	0
CYP4F11	57834	broad.mit.edu	37	19	16040288	16040288	+	Missense_Mutation	SNP	G	A	A	rs138578304		TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:16040288G>A	uc002nbu.2	-	3	358	c.322C>T	c.(322-324)CGG>TGG	p.R108W	CYP4F11_uc010eab.1_Missense_Mutation_p.R108W|CYP4F11_uc002nbt.2_Missense_Mutation_p.R108W	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	108					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						GTGATAGGCCGGATAATGTCA	0.557000													21	120					0	0	0.00047179	0	0
ZNF208	7757	broad.mit.edu	37	19	22154362	22154362	+	Silent	SNP	A	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:22154362A>G	uc002nqp.2	-	6	3239	c.3090T>C	c.(3088-3090)TAT>TAC	p.Y1030Y	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTTTCTTATGATAACTAAGGG	0.353000													5	41					0	0	8.12818e-05	0	0
ZNF208	7757	broad.mit.edu	37	19	22155346	22155346	+	Silent	SNP	T	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:22155346T>C	uc002nqp.2	-	5	2339	c.2190A>G	c.(2188-2190)GAA>GAG	p.E730E	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGTAGGGCTTTTCTCCAGCAT	0.373000													3	67					0	0	6.4e-05	0	0
ZNF676	163223	broad.mit.edu	37	19	22363738	22363738	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:22363738C>T	uc002nqs.1	-	3	1099	c.781G>A	c.(781-783)GGA>AGA	p.G261R		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	261	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CTACTAAATCCTTTGCCACAT	0.393000													15	37					0	0	0.000566183	0	0
ZNF99	7652	broad.mit.edu	37	19	22939264	22939264	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:22939264C>T	uc010xrh.1	-	7	2907	c.2907G>A	c.(2905-2907)AAG>AAA	p.K969K		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTAGGGTTTCTTTCCAGTAT	0.368000													13	18					0	0	0.00010058	0	0
ZNF99	7652	broad.mit.edu	37	19	22940294	22940294	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:22940294T>A	uc010xrh.1	-	5	2144	c.2144A>T	c.(2143-2145)AAA>ATA	p.K715I		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TATCTCATGTTTTCTAAGGGT	0.333000													11	37					0	0	3.86212e-05	0	0
ZNF536	9745	broad.mit.edu	37	19	31039944	31039944	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:31039944C>A	uc002nsu.1	+	4	3556	c.3418C>A	c.(3418-3420)CAC>AAC	p.H1140N	ZNF536_uc010edd.1_Missense_Mutation_p.H1140N	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGGAAAGGCCCACTCTGAAGA	0.542000													14	44					4.3838e-07	1.28464e-05	0.000151284	1	0
CRX	1406	broad.mit.edu	37	19	48343031	48343031	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:48343031C>T	uc002phq.3	+	4	911	c.707C>T	c.(706-708)CCC>CTC	p.P236L		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	236					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		GCTCTTAGCCCCCTCTCTGGC	0.647000													22	123					0	0	0.00047179	0	0
NLRP7	199713	broad.mit.edu	37	19	55445871	55445871	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr19:55445871G>A	uc002qih.3	-	7	2533	c.2457C>T	c.(2455-2457)TTC>TTT	p.F819F	NLRP7_uc002qig.3_Silent_p.F791F|NLRP7_uc002qii.3_Silent_p.F819F|NLRP7_uc010esk.2_Silent_p.F819F|NLRP7_uc010esl.2_Silent_p.F847F	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	819	LRR 5.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		ACATCTGCAGGAAGTGTTTTG	0.532000													12	80					0	0	0.000151284	0	0
HADHA	3030	broad.mit.edu	37	2	26427001	26427002	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr2:26427001_26427002CC>AA	uc002rgy.2	-	12	1279_1280	c.1149_1150GG>TT	c.(1147-1152)AAGGGG>AATTGG	p.383_384KG>NW	HADHA_uc010yks.1_Missense_Mutation_p.296_297KG>NW	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	383_384					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	GTCTTTAGCCCCTTATCCACGG	0.505000													11	383					0	0	6.4e-05	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43953541	43953542	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr2:43953541_43953542CC>AA	uc010yny.1	+	17	2755_2756	c.2672_2673CC>AA	c.(2671-2673)CCC>CAA	p.P891Q	PLEKHH2_uc002rtf.3_Missense_Mutation_p.P890Q	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	891	PH 2.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTTATCCATCCCAAAGACCAAG	0.371000													12	451					0	0	6.4e-05	0	0
RTKN	6242	broad.mit.edu	37	2	74654713	74654713	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr2:74654713G>A	uc002sle.2	-	10	1210	c.1093C>T	c.(1093-1095)CGA>TGA	p.R365*	RTKN_uc002slc.2_Nonsense_Mutation_p.R352*|RTKN_uc002sld.2_Nonsense_Mutation_p.R315*	NM_001015055	NP_001015055	Q9BST9	RTKN_HUMAN	rhotekin isoform a	365	PH.			RV -> PI (in Ref. 3; AAG01181).	apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1						GCCCGGACTCGAGTCTCCTGC	0.547000													25	141					0	0	0.000147802	0	0
INPP4A	3631	broad.mit.edu	37	2	99149957	99149957	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr2:99149957A>G	uc002syy.2	+	5	662	c.269A>G	c.(268-270)GAG>GGG	p.E90G	INPP4A_uc010yvj.1_Missense_Mutation_p.E90G|INPP4A_uc010yvk.1_Missense_Mutation_p.E90G|INPP4A_uc002syx.2_Missense_Mutation_p.E90G|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	90	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						GAGATCATTGAGGTGGGTGCT	0.522000													5	52					0	0	3.59834e-05	0	0
PTPN18	26469	broad.mit.edu	37	2	131116970	131116970	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr2:131116970G>C	uc002trc.2	+	4	381	c.280G>C	c.(280-282)GGC>CGC	p.G94R	PTPN18_uc002trd.2_Missense_Mutation_p.G94R|PTPN18_uc002trb.2_Intron	NM_014369	NP_055184	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type	94	Tyrosine-protein phosphatase.					cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			ovary(3)|kidney(1)	4	Colorectal(110;0.1)					CCTTCACCAGGGCGTGGATGG	0.607000													7	45					0	0	8.12818e-05	0	0
SCN2A	6326	broad.mit.edu	37	2	166231203	166231203	+	Silent	SNP	A	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr2:166231203A>G	uc002udc.2	+	22	4271	c.3981A>G	c.(3979-3981)GTA>GTG	p.V1327V	SCN2A_uc002udd.2_Silent_p.V1327V|SCN2A_uc002ude.2_Silent_p.V1327V	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1327	III.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGGTTGTTGTAAATGCTCTTT	0.328000													18	129					0	0	0.000175454	0	0
TTN	7273	broad.mit.edu	37	2	179597184	179597184	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr2:179597184G>T	uc010zfg.1	-	53	13096	c.12872C>A	c.(12871-12873)GCA>GAA	p.A4291E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A952E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5218							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAACAAGTTTGCACTGCATTC	0.388000													13	65					4.3838e-07	1.28464e-05	0.000151284	1	0
COL5A2	1290	broad.mit.edu	37	2	189904130	189904130	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr2:189904130C>T	uc002uqk.2	-	51	4068	c.3793G>A	c.(3793-3795)GAC>AAC	p.D1265N	COL5A2_uc010frx.2_Missense_Mutation_p.D841N	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1265					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			ACCCCTGGGTCCGTTTTGTTT	0.517000													20	34					0	0	9.7654e-05	0	0
WDR12	55759	broad.mit.edu	37	2	203760887	203760888	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr2:203760887_203760888CC>AA	uc002uzl.2	-	6	1259_1260	c.509_510GG>TT	c.(508-510)TGG>TTT	p.W170F	WDR12_uc010ftt.2_Missense_Mutation_p.W170F	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	170	WD 2.|Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						CATTCCACTCCCATAAGAGAAT	0.396000													13	611					0	0	6.4e-05	0	0
SLC24A3	57419	broad.mit.edu	37	20	19677546	19677546	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr20:19677546G>A	uc002wrl.2	+	14	1794	c.1597G>A	c.(1597-1599)GCC>ACC	p.A533T		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	533	Cytoplasmic (Potential).|Alpha-2.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						CCTCATTGTGGCCAGACAAGG	0.373000													6	49					0	0	8.12818e-05	0	0
DYNLRB1	83658	broad.mit.edu	37	20	33122560	33122560	+	Silent	SNP	C	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr20:33122560C>A	uc002xal.2	+	3	268	c.208C>A	c.(208-210)CGA>AGA	p.R70R	DYNLRB1_uc010zuk.1_Silent_p.R70R|DYNLRB1_uc002xam.2_RNA|DYNLRB1_uc002xan.2_RNA	NM_014183	NP_054902	Q9NP97	DLRB1_HUMAN	Roadblock-1	70					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity				0						CACCTTCCTTCGAATTCGCTC	0.537000													7	50					5.18039e-06	0.000149213	0.000157383	1	0
TRPM2	7226	broad.mit.edu	37	21	45825902	45825902	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr21:45825902C>T	uc002zet.1	+	19	2985	c.2772C>T	c.(2770-2772)ATC>ATT	p.I924I	TRPM2_uc002zeu.1_Silent_p.I924I|TRPM2_uc002zew.1_Silent_p.I924I|TRPM2_uc010gpt.1_Silent_p.I924I|TRPM2_uc002zex.1_Silent_p.I710I|TRPM2_uc002zey.1_Silent_p.I437I	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	924	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCCCAAGATCATCATTGTGA	0.642000													25	109					0	0	0.000279167	0	0
SGSM1	129049	broad.mit.edu	37	22	25255689	25255689	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr22:25255689G>A	uc003abg.2	+	9	965	c.808G>A	c.(808-810)GAC>AAC	p.D270N	SGSM1_uc003abh.2_Missense_Mutation_p.D270N|SGSM1_uc010guu.1_Missense_Mutation_p.D270N|SGSM1_uc003abj.2_Missense_Mutation_p.D270N|SGSM1_uc003abi.1_Missense_Mutation_p.D245N|SGSM1_uc003abf.2_Missense_Mutation_p.D270N	NM_001039948	NP_001035037	Q2NKQ1	SGSM1_HUMAN	RUN and TBC1 domain containing 2 isoform 1	270						Golgi apparatus	Rab GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)	5						GCAGAGGGACGACATGGAGGC	0.562000													9	25					0	0	0.000274275	0	0
SLC5A1	6523	broad.mit.edu	37	22	32464543	32464543	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr22:32464543C>T	uc003amc.2	+	5	665	c.433C>T	c.(433-435)CTT>TTT	p.L145F	SLC5A1_uc011alz.1_Missense_Mutation_p.L18F	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	145	Helical; (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						CCAGGTCTACCTTTCCCTTCT	0.582000													18	47					0	0	0.000295444	0	0
MAGI1	9223	broad.mit.edu	37	3	65342698	65342698	+	Silent	SNP	G	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr3:65342698G>T	uc003dmn.2	-	23	4270	c.3744C>A	c.(3742-3744)CCC>CCA	p.P1248P	MAGI1_uc003dmm.2_3'UTR	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1277					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TGTGAAGATCGGGTGGGTAAC	0.612000													9	65					3.07112e-06	8.92213e-05	6.40141e-05	1	0
PLCH1	23007	broad.mit.edu	37	3	155199996	155199996	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr3:155199996G>A	uc011bok.1	-	23	4120	c.3843C>T	c.(3841-3843)CCC>CCT	p.P1281P	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.P1243P	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1281					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TTTTAGAGATGGGAGTGCAGG	0.488000													32	176					0	0	0.000132358	0	0
SLC7A11	23657	broad.mit.edu	37	4	139163201	139163201	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr4:139163201G>A	uc011chb.1	-	1	303	c.23C>T	c.(22-24)TCC>TTC	p.S8F		NM_014331	NP_055146	Q9UPY5	XCT_HUMAN	solute carrier family 7, (cationic amino acid	8	Cytoplasmic (Potential).				blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			skin(1)	1	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	GGAGATGGTGGACACAACAGG	0.493000													6	21					0	0	3.59834e-05	0	0
CPE	1363	broad.mit.edu	37	4	166416819	166416819	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr4:166416819C>G	uc003irg.3	+	8	1599	c.1322C>G	c.(1321-1323)CCT>CGT	p.P441R		NM_001873	NP_001864	P16870	CBPE_HUMAN	carboxypeptidase E preproprotein	441					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTTACAGCCCTGCTGCTGGG	0.303000													3	49					0	0	6.4e-05	0	0
CDH12	1010	broad.mit.edu	37	5	21975347	21975347	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:21975347G>C	uc010iuc.2	-	3	837	c.379C>G	c.(379-381)CTT>GTT	p.L127V	CDH12_uc011cno.1_Missense_Mutation_p.L127V|CDH12_uc003jgk.2_Missense_Mutation_p.L127V	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	127	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TGAGCACGAAGAGTGTAGAAA	0.448000										HNSCC(59;0.17)			11	66					0	0	6.40141e-05	0	0
IL31RA	133396	broad.mit.edu	37	5	55206397	55206397	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:55206397G>A	uc003jql.2	+	12	1604	c.1539G>A	c.(1537-1539)CTG>CTA	p.L513L	IL31RA_uc003jqm.2_Silent_p.L481L|IL31RA_uc003jqn.2_Silent_p.L513L|IL31RA_uc010iwa.1_Silent_p.L476L|IL31RA_uc003jqo.2_Silent_p.L371L	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	481	Extracellular (Potential).|Fibronectin type-III 5.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				AGTACGGCCTGGAGTCCCTGA	0.468000													13	69					0	0	0.000308642	0	0
WDR41	55255	broad.mit.edu	37	5	76734149	76734149	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:76734149T>C	uc003kff.1	-	10	1207	c.920A>G	c.(919-921)TAT>TGT	p.Y307C	WDR41_uc011csy.1_Missense_Mutation_p.Y249C|WDR41_uc011csz.1_Missense_Mutation_p.Y252C|WDR41_uc011cta.1_RNA	NM_018268	NP_060738	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	307											0		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		TTGAAGGCTATACACGTATAA	0.448000													23	74					0	0	0.000229342	0	0
JMY	133746	broad.mit.edu	37	5	78610271	78610271	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:78610271C>T	uc003kfx.3	+	9	2776	c.2256C>T	c.(2254-2256)CCC>CCT	p.P752P	JMY_uc003kfw.1_Silent_p.P398P	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	752					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		CAACAGAACCCCAGAGCCTTG	0.458000													26	126					0	0	0.00047179	0	0
RAB9BP1	9366	broad.mit.edu	37	5	104435182	104435182	+	RNA	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:104435182G>A	uc003kok.2	+	1		c.8G>A				NR_000039				Homo sapiens RAB9, member RAS oncogene family, pseudogene 1 (RAB9P1), non-coding RNA.												0						TTAACGGCAGGAAAATCATCA	0.358000													10	9					0	0	0.000442599	0	0
APC	324	broad.mit.edu	37	5	112175907	112175907	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:112175907C>T	uc010jby.2	+	16	4996	c.4616C>T	c.(4615-4617)TCA>TTA	p.S1539L	APC_uc011cvt.1_Missense_Mutation_p.S1521L|APC_uc003kpz.3_Missense_Mutation_p.S1539L|APC_uc003kpy.3_Missense_Mutation_p.S1539L|APC_uc010jbz.2_Missense_Mutation_p.S1256L|APC_uc010jca.2_Missense_Mutation_p.S839L	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1539	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E1540fs*4(1)|p.K1192fs*3(1)|p.?(1)|p.S1539*(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GAAACAGAATCAGAGCAGCCT	0.368000		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			12	72					0	0	6.40141e-05	0	0
CDKL3	51265	broad.mit.edu	37	5	133657520	133657520	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:133657520G>C	uc003kzf.3	-	5	733	c.614C>G	c.(613-615)TCT>TGT	p.S205C	CDKL3_uc011cxm.1_Missense_Mutation_p.S12C|CDKL3_uc011cxn.1_RNA|CDKL3_uc010jdw.2_5'UTR|CDKL3_uc011cxo.1_5'UTR|CDKL3_uc011cxp.1_5'UTR|CDKL3_uc011cxq.1_Missense_Mutation_p.S12C|CDKL3_uc003kzg.3_Missense_Mutation_p.S205C|CDKL3_uc011cxr.1_Missense_Mutation_p.S205C	NM_001113575	NP_001107047	Q8IVW4	CDKL3_HUMAN	cyclin-dependent kinase-like 3 isoform 1	205	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATCCAAATCAGAACTACTAGG	0.358000													4	30					0	0	3.59834e-05	0	0
SLIT3	6586	broad.mit.edu	37	5	168271604	168271604	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:168271604C>T	uc003mab.2	-	6	962	c.542G>A	c.(541-543)CGC>CAC	p.R181H	SLIT3_uc010jjg.2_Missense_Mutation_p.R181H|SLIT3_uc010jji.2_Missense_Mutation_p.R181H|SLIT3_uc003mac.1_5'UTR	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	181					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCCAAATCGCGCAGCGCTCG	0.458000													21	16					0	0	0.000117367	0	0
FAF2	23197	broad.mit.edu	37	5	175927043	175927043	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:175927043C>T	uc003mej.3	+	10	1104	c.1051C>T	c.(1051-1053)CCC>TCC	p.P351S		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	351					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						GGAATGCCTGCCCCCTGAACC	0.428000													14	111					0	0	0.000308642	0	0
FAF2	23197	broad.mit.edu	37	5	175927084	175927084	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:175927084C>G	uc003mej.3	+	10	1145	c.1092C>G	c.(1090-1092)ATC>ATG	p.I364M		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	364	UBX.				response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						GTGTCAAGATCATCTTCAAAT	0.433000													14	115					0	0	0.000566183	0	0
SLC17A1	6568	broad.mit.edu	37	6	25813338	25813338	+	Silent	SNP	G	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr6:25813338G>T	uc003nfh.3	-	7	836	c.720C>A	c.(718-720)TCC>TCA	p.S240S	SLC17A1_uc011djy.1_Intron|SLC17A1_uc010jqb.1_Silent_p.S238S|SLC17A1_uc010jqc.1_Silent_p.S238S	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	240					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						GGACCAGGGAGGATGTGATGT	0.433000													18	96					5.3912e-06	0.000152675	7.07596e-05	1	0
HLA-B	3106	broad.mit.edu	37	6	31323218	31323218	+	Silent	SNP	G	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr6:31323218G>C	uc003nth.2	-	4	825	c.771C>G	c.(769-771)ACC>ACG	p.T257T	HLA-C_uc003ntb.2_RNA|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_RNA|HLA-B_uc011dnk.1_RNA|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Silent_p.T136T|HLA-B_uc003nti.1_RNA|HLA-B_uc010jsn.1_RNA	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	257	Alpha-3.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						CTGCTGGTCTGGTCTCCACAA	0.587000									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				14	55					0	0	0.000219431	0	0
EGFR	1956	broad.mit.edu	37	7	55221747	55221747	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr7:55221747G>A	uc003tqk.2	+	7	1037	c.791G>A	c.(790-792)TGC>TAC	p.C264Y	EGFR_uc003tqh.2_Missense_Mutation_p.C264Y|EGFR_uc003tqi.2_Missense_Mutation_p.C264Y|EGFR_uc003tqj.2_Missense_Mutation_p.C264Y|EGFR_uc010kzg.1_Missense_Mutation_p.C219Y|EGFR_uc011kco.1_Missense_Mutation_p.C211Y|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	264	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AAGGACACCTGCCCCCCACTC	0.577000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			9	44					0	0	0.000442599	0	0
SLC26A3	1811	broad.mit.edu	37	7	107418723	107418723	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr7:107418723T>A	uc003ver.2	-	13	1622	c.1411A>T	c.(1411-1413)ATT>TTT	p.I471F	SLC26A3_uc003ves.2_Missense_Mutation_p.I436F	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	471	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						ATGATCCAAATTAACTGTGAA	0.393000													5	34					0	0	0.000602214	0	0
GPR85	54329	broad.mit.edu	37	7	112724287	112724287	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr7:112724287A>G	uc010ljv.2	-	2	1007	c.490T>C	c.(490-492)TCA>CCA	p.S164P	GPR85_uc003vgp.1_Missense_Mutation_p.S164P|GPR85_uc003vgq.2_Missense_Mutation_p.S164P|GPR85_uc010ljw.1_Missense_Mutation_p.S164P	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	164	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						CTAATGAATGAGTAAGTGCCC	0.498000													3	89					0	0	6.4e-05	0	0
KCND2	3751	broad.mit.edu	37	7	119914938	119914938	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr7:119914938C>T	uc003vjj.1	+	1	1217	c.252C>T	c.(250-252)TTC>TTT	p.F84F		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	84	Cytoplasmic (Potential).|Interaction with KCNIP1 (By similarity).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					AGCAGTATTTCTTTGACCGTG	0.527000													21	149					0	0	0.000295444	0	0
C7orf58	79974	broad.mit.edu	37	7	120906769	120906769	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr7:120906769C>T	uc003vjq.3	+	20	2987	c.2540C>T	c.(2539-2541)CCC>CTC	p.P847L		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	847						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AGATCACGTCCCCTAGAGAAT	0.398000													9	89					0	0	3.86212e-05	0	0
GRM8	2918	broad.mit.edu	37	7	126173763	126173763	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr7:126173763A>G	uc003vlr.2	-	8	1984	c.1673T>C	c.(1672-1674)CTG>CCG	p.L558P	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.L558P|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	558	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TCTCTGATCCAGAGGGCAAAG	0.532000										HNSCC(24;0.065)			18	107					0	0	0.000175454	0	0
ATP6V1F	9296	broad.mit.edu	37	7	128505545	128505545	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr7:128505545C>T	uc003voc.1	+	2	334	c.273C>T	c.(271-273)ATC>ATT	p.I91I	KCP_uc003vob.1_Intron	NM_004231	NP_004222	Q16864	VATF_HUMAN	ATPase, H+ transporting, lysosomal 14kD, V1	91					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|membrane fraction|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATPase activity, uncoupled|hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						TCCTGGAGATCCCCTCCAAGG	0.612000													5	40					0	0	0.000602214	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				73	28					0	0	0.000147903	0	0
MGAM	8972	broad.mit.edu	37	7	141799419	141799419	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr7:141799419G>A	uc003vwy.2	+	44	5122	c.5068G>A	c.(5068-5070)GAT>AAT	p.D1690N		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1690	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCAGGGTGTGGATATTAATGC	0.537000													51	52					0	0	0.000147903	0	0
FLJ10661	286042	broad.mit.edu	37	8	8092061	8092061	+	RNA	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr8:8092061C>T	uc011kwt.1	+	4		c.429C>T			FLJ10661_uc010lrq.2_Intron|FLJ10661_uc003wsf.3_RNA	NR_024362				Homo sapiens cDNA FLJ60033 complete cds, highly similar to Protein FAM86A.												0						TGGCGGAGACCCTGATGGCCA	0.572000													8	34					0	0	6.40141e-05	0	0
RP1	6101	broad.mit.edu	37	8	55540425	55540425	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr8:55540425C>A	uc003xsd.1	+	4	4131	c.3983C>A	c.(3982-3984)CCA>CAA	p.P1328Q	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1328					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGAGCTTGCCCAATTGATGAG	0.403000													7	114					0.000157383	0.00438332	0.000157383	1	0
CLVS1	157807	broad.mit.edu	37	8	62212623	62212623	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr8:62212623T>G	uc003xuh.2	+	2	561	c.237T>G	c.(235-237)TTT>TTG	p.F79L	CLVS1_uc003xug.2_Missense_Mutation_p.F79L|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Missense_Mutation_p.F79L	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	79					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						TCCTGAGATTTCTCCGAGCCA	0.463000													4	51					0	0	0.00024832	0	0
RDH10	157506	broad.mit.edu	37	8	74235028	74235028	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr8:74235028C>T	uc003xzi.2	+	5	1145	c.885C>T	c.(883-885)ATC>ATT	p.I295I	RDH10_uc003xzj.2_Silent_p.I130I|uc003xzk.1_Intron	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10	295					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity				0	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			TCATGTACATCGTGACCTTCA	0.522000													29	41					0	0	0.000227799	0	0
STAU2	27067	broad.mit.edu	37	8	74516060	74516060	+	Silent	SNP	G	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr8:74516060G>A	uc003xzm.2	-	10	1166	c.930C>T	c.(928-930)AGC>AGT	p.S310S	STAU2_uc011lfg.1_Silent_p.S138S|STAU2_uc003xzn.2_Silent_p.S278S|STAU2_uc011lfh.1_Silent_p.S206S|STAU2_uc003xzo.2_Silent_p.S310S|STAU2_uc003xzp.2_Silent_p.S278S|STAU2_uc011lfi.1_Silent_p.S272S|STAU2_uc003xzq.2_Silent_p.S90S|STAU2_uc010lzk.2_Silent_p.S278S|STAU2_uc010lzl.1_Silent_p.S138S	NM_014393	NP_055208	Q9NUL3	STAU2_HUMAN	staufen homolog 2 isoform e	310	DRBM 4.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding				0	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			GCGCCAGGCGGCTAATAGGGT	0.408000													14	47					0	0	0.000219431	0	0
IFNA21	3452	broad.mit.edu	37	9	21166051	21166051	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr9:21166051C>T	uc003zom.2	-	1	609	c.561G>A	c.(559-561)AGG>AGA	p.R187R		NM_002175	NP_002166	P01568	IFN21_HUMAN	interferon, alpha 21 precursor	187					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TTCATTCCTTCCTCCTTAATC	0.383000													16	79					0	0	0.000308642	0	0
TAF1L	138474	broad.mit.edu	37	9	32631651	32631651	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr9:32631651C>T	uc003zrg.1	-	1	4017	c.3927G>A	c.(3925-3927)TCG>TCA	p.S1309S	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1309					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CAACAGGTTTCGAAGGTGGCA	0.428000													75	129					0	0	0.000147903	0	0
NFX1	4799	broad.mit.edu	37	9	33328583	33328583	+	Silent	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr9:33328583C>T	uc003zsq.2	+	10	1972	c.1911C>T	c.(1909-1911)TTC>TTT	p.F637F	SUGT1P1_uc010mjq.1_Intron|NFX1_uc011lnw.1_Silent_p.F637F|NFX1_uc003zso.2_Silent_p.F637F|NFX1_uc003zsp.1_Silent_p.F637F|NFX1_uc010mjr.1_Silent_p.F637F|NFX1_uc003zsr.2_Silent_p.F637F	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	637	NF-X1-type 4.				inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		TTAAAGATTTCATTCATACCT	0.418000													15	77					0	0	0.000308642	0	0
LOC442421	442421	broad.mit.edu	37	9	66500871	66500871	+	RNA	SNP	T	C	C	rs11262348		TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr9:66500871T>C	uc004aed.1	+	3		c.964T>C								Homo sapiens similar to prostaglandin E receptor 4, subtype EP4; PGE receptor, EP4 subtype; prostaglandin E2 receptor, mRNA (cDNA clone IMAGE:5288780).												0						TACACGGAACTGCTGTTGGTC	0.597000													4	24					0	0	0.000602214	0	0
FANCC	2176	broad.mit.edu	37	9	97887370	97887370	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr9:97887370G>T	uc004avh.2	-	10	1256	c.994C>A	c.(994-996)CAG>AAG	p.Q332K	FANCC_uc004avi.3_Missense_Mutation_p.Q332K|uc004avj.2_5'Flank	NM_000136	NP_000127	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	332					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)	1		Acute lymphoblastic leukemia(62;0.138)				TAACAAACCTGCTTGCTTGCT	0.418000			D|Mis|N|F|S			AML|leukemia		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				14	27					0.000308642	0.0085256	0.000308642	1	0
TNC	3371	broad.mit.edu	37	9	117846627	117846627	+	Silent	SNP	C	A	A			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr9:117846627C>A	uc004bjj.3	-	4	2354	c.1992G>T	c.(1990-1992)CTG>CTT	p.L664L	TNC_uc010mvf.2_Silent_p.L664L	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	664	Fibronectin type-III 1.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						ACTGCATTTCCAGACCACCCT	0.567000													6	33					2.7689e-08	8.25768e-07	8.12818e-05	1	0
OR1Q1	158131	broad.mit.edu	37	9	125377374	125377374	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr9:125377374T>C	uc011lyy.1	+	1	358	c.358T>C	c.(358-360)TAT>CAT	p.Y120H		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGTGATGGCCTATGACAGGTA	0.473000													3	130					0	0	6.4e-05	0	0
XK	7504	broad.mit.edu	37	X	37545249	37545249	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chrX:37545249T>G	uc004ddq.2	+	1	117	c.35T>G	c.(34-36)TTC>TGC	p.F12C		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	12	Helical; (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				GCGTCCGTGTTCCTGTTCGTG	0.697000													3	2					0	0	0.00024832	0	0
ODZ1	10178	broad.mit.edu	37	X	123519727	123519727	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chrX:123519727C>T	uc004euj.2	-	28	5919	c.5855G>A	c.(5854-5856)CGA>CAA	p.R1952Q	ODZ1_uc011muj.1_Missense_Mutation_p.R1958Q|ODZ1_uc010nqy.2_Missense_Mutation_p.R1959Q	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1952	YD 11.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCGGCCATCTCGACTATAGTC	0.498000													44	27					0	0	0.000589545	0	0
TMEM52	339456	broad.mit.edu	37	1	1850628	1850636	+	In_Frame_Del	DEL	AGCGGCAGG	-	-			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr1:1850628_1850636delAGCGGCAGG	uc001aij.2	-	1	105_113	c.69_77delCCTGCCGCT	c.(67-78)CTCCTGCCGCTG>CTG	p.23_26LLPL>L	TMEM52_uc001aii.2_5'Flank	NM_178545	NP_848640	Q8NDY8	TMM52_HUMAN	transmembrane protein 52 precursor	23_26						integral to membrane					0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACCTgcggcagcggcaggagcggcagga	0.569													5	5	---	---	---	---					
UBQLN3	50613	broad.mit.edu	37	11	5529918	5529920	+	In_Frame_Del	DEL	TGG	-	-	rs2234451	byFrequency	TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr11:5529918_5529920delTGG	uc001may.1	-	2	955_957	c.869_871delCCA	c.(868-873)ACCAGC>AGC	p.T290del	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	290										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAGGTTGGCTGGTGGTGGTGGT	0.537													7	168	---	---	---	---					
CPD	1362	broad.mit.edu	37	17	28769357	28769358	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr17:28769357_28769358delAA	uc002hfb.1	+	10	2277_2278	c.2262_2263delAA	c.(2260-2265)ACAAATfs	p.T754fs	CPD_uc010wbo.1_Frame_Shift_Del_p.T507fs|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	754_755	Extracellular (Potential).|Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						ATTTACAAACAAATTGCTTTGA	0.361													23	119	---	---	---	---					
PPARGC1B	133522	broad.mit.edu	37	5	149216400	149216402	+	In_Frame_Del	DEL	CAG	-	-			TCGA-EE-A2M7-06A-11D-A197-08	TCGA-EE-A2M7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	dc5d0f51-0461-4183-bbda-a47dbfbb0052	2ad50067-18fc-4eee-ae12-3db1c6a59847	g.chr5:149216400_149216402delCAG	uc003lrc.2	+	8	2424_2426	c.2382_2384delCAG	c.(2380-2385)GACAGC>GAC	p.S799del	PPARGC1B_uc003lrb.1_In_Frame_Del_p.S799del|PPARGC1B_uc003lrd.2_In_Frame_Del_p.S760del|PPARGC1B_uc003lrf.2_In_Frame_Del_p.S778del|PPARGC1B_uc003lre.1_In_Frame_Del_p.S778del	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	799	Glu-rich.				estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TCTTTGAAGACAGCAGCAGCAGC	0.453													7	127	---	---	---	---					
