Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C1orf159	54991	broad.mit.edu	37	1	1019612	1019612	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:1019612C>T	uc001act.2	-	11	1217	c.731G>A	c.(730-732)GGG>GAG	p.G244E	C1orf159_uc001acu.2_Intron|C1orf159_uc001acr.2_Intron|C1orf159_uc001acs.2_Intron|C1orf159_uc010nyd.1_Intron|C1orf159_uc001acm.2_Intron|C1orf159_uc009vju.1_Intron|C1orf159_uc001acn.2_Missense_Mutation_p.G208E|C1orf159_uc001acp.2_Intron	NM_017891	NP_060361	Q96HA4	CA159_HUMAN	hypothetical protein LOC54991	244	Pro-rich.					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		TCCTGGGGACCCGGGCAGGGG	0.687													3	51					0	0	0.014758	0	0
TAS1R1	80835	broad.mit.edu	37	1	6635361	6635361	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:6635361A>G	uc001ant.2	+	3	1169	c.1169A>G	c.(1168-1170)TAC>TGC	p.Y390C	TAS1R1_uc001anu.2_Intron|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_Missense_Mutation_p.Y390C	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	390	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TACAACGCATACCGGGCTGTG	0.587													12	42					0	0	0.013537	0	0
VPS13D	55187	broad.mit.edu	37	1	12343435	12343435	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:12343435C>T	uc001atv.2	+	21	5417	c.5276C>T	c.(5275-5277)CCC>CTC	p.P1759L	VPS13D_uc001atw.2_Missense_Mutation_p.P1759L|VPS13D_uc001atx.2_Missense_Mutation_p.P947L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1759					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AAGGACTATCCCTTGACCCCA	0.458													5	35					0	0	0.014758	0	0
CTRC	11330	broad.mit.edu	37	1	15772132	15772132	+	Missense_Mutation	SNP	G	A	A	rs142027137		TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:15772132G>A	uc001awi.1	+	7	703	c.680G>A	c.(679-681)GGT>GAT	p.G227D	CTRC_uc001awj.1_Silent_p.R178R	NM_007272	NP_009203	Q99895	CTRC_HUMAN	chymotrypsin C preproprotein	227	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTGGAGAACGGTTCCTGGGAG	0.647													24	65					0	0	0.018920	0	0
CELA2A	63036	broad.mit.edu	37	1	15789236	15789236	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:15789236G>A	uc001awk.2	+	4	262	c.236G>A	c.(235-237)AGG>AAG	p.R79K		NM_033440	NP_254275	P08217	CEL2A_HUMAN	elastase 2A preproprotein	79	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						AGCTCCTCCAGGACCTACCGC	0.617													18	62					0	0	0.007413	0	0
MST1P2	11209	broad.mit.edu	37	1	16974686	16974686	+	RNA	SNP	G	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:16974686G>T	uc010och.1	+	7		c.1146G>T			MST1P2_uc001azk.2_RNA|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						ACGACGTGCGGCCCCAGGGTG	0.711													6	39					0.000274275	0.000283418	0.004482	1	0
Unknown	0	broad.mit.edu	37	1	21752758	21752758	+	RNA	SNP	T	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:21752758T>A	uc001bep.1	-	3		c.218A>T								Homo sapiens cDNA FLJ25572 fis, clone JTH05111.																		CAACGTGTTCTTCCTCCAATG	0.453													9	82					0	0	0.006214	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26885410	26885410	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:26885410C>T	uc001bmr.1	+	14	1360	c.1197C>T	c.(1195-1197)CCC>CCT	p.P399P	RPS6KA1_uc010ofe.1_Silent_p.P307P|RPS6KA1_uc010off.1_Silent_p.P383P|RPS6KA1_uc001bms.1_Silent_p.P408P|RPS6KA1_uc009vsl.1_Silent_p.P242P	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	399					axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		CGCAGGCACCCCTGCACTCGG	0.632													16	35					0	0	0.006122	0	0
SPOCD1	90853	broad.mit.edu	37	1	32264052	32264052	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:32264052G>A	uc001bts.1	-	8	2077	c.2019C>T	c.(2017-2019)CCC>CCT	p.P673P	SPOCD1_uc001btt.2_5'UTR|SPOCD1_uc001btu.2_Silent_p.P673P|SPOCD1_uc001btv.2_Silent_p.P166P|SPOCD1_uc001btw.1_5'UTR	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	673	TFIIS central.				transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CCAGGTTCCTGGGGTCCCGCA	0.617													14	37					0	0	0.004990	0	0
SPOCD1	90853	broad.mit.edu	37	1	32265660	32265660	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:32265660G>A	uc001bts.1	-	5	1743	c.1685C>T	c.(1684-1686)TCC>TTC	p.S562F	SPOCD1_uc001btt.2_5'Flank|SPOCD1_uc001btu.2_Missense_Mutation_p.S562F|SPOCD1_uc001btv.2_Missense_Mutation_p.S55F|SPOCD1_uc001btw.1_5'Flank	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	562					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		AAGGGCCAGGGAACCGCTTCT	0.632													7	38					0	0	0.001984	0	0
MRPS15	64960	broad.mit.edu	37	1	36921790	36921790	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:36921790G>A	uc001cas.2	-	7	798	c.634C>T	c.(634-636)CGG>TGG	p.R212W		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	212					translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				ACTCGTACCCGAATGCACAGA	0.547													6	39					0	0	0.003080	0	0
CYP4B1	1580	broad.mit.edu	37	1	47278227	47278227	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:47278227C>A	uc001cqm.3	+	4	511	c.427C>A	c.(427-429)CCT>ACT	p.P143T	CYP4B1_uc009vyl.1_5'UTR|CYP4B1_uc001cqn.3_Missense_Mutation_p.P143T|CYP4B1_uc009vym.2_Missense_Mutation_p.P128T|CYP4B1_uc010omk.1_5'UTR|CYP4B1_uc010oml.1_5'UTR	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	143					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					GCTGCTCACACCTGGCTTTCA	0.587													10	61					1.76689e-08	1.8495e-08	0.006214	1	0
SCP2	6342	broad.mit.edu	37	1	53420478	53420478	+	Splice_Site	SNP	T	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:53420478T>A	uc001cur.1	+	5	517	c.396_splice	c.e5+2	p.K132_splice	SCP2_uc001cus.1_Splice_Site|SCP2_uc010ono.1_Splice_Site_p.K51_splice|SCP2_uc010onp.1_Splice_Site_p.K108_splice|SCP2_uc009vzi.1_Splice_Site_p.K88_splice|SCP2_uc001cuq.1_Splice_Site_p.K88_splice	NM_002979	NP_002970	P22307	NLTP_HUMAN	sterol carrier protein 2 isoform 1 proprotein						bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)	1						GGAATAAAAGTGAGTGTTATT	0.299													10	60					0	0	0.010729	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507089	74507089	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:74507089G>A	uc001dfy.3	-	7	1718	c.1526C>T	c.(1525-1527)TCC>TTC	p.S509F	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	509										ovary(2)	2						AGCCTTTTGGGATTTTTCTTT	0.358													8	83					0	0	0.003080	0	0
GBP3	2635	broad.mit.edu	37	1	89480263	89480263	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:89480263C>T	uc001dmt.2	-	4	600	c.395G>A	c.(394-396)GGA>GAA	p.G132E	GBP3_uc010oss.1_Missense_Mutation_p.G53E|GBP3_uc001dmu.2_5'UTR|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	132	Helical; (Potential).					integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		GTTGATGGTTCCCATGCTATT	0.522													26	76					0	0	0.007291	0	0
COL11A1	1301	broad.mit.edu	37	1	103471395	103471395	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:103471395C>T	uc001dul.2	-	18	2162	c.1844G>A	c.(1843-1845)AGG>AAG	p.R615K	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.R627K|COL11A1_uc001dun.2_Missense_Mutation_p.R576K|COL11A1_uc009weh.2_Missense_Mutation_p.R499K	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	615	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTATCTTACCCTGTGACCTTT	0.289													22	72					0	0	0.018920	0	0
DDX20	11218	broad.mit.edu	37	1	112309444	112309444	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:112309444C>T	uc001ebs.2	+	11	2755	c.2398C>T	c.(2398-2400)CAG>TAG	p.Q800*	DDX20_uc010owf.1_Nonsense_Mutation_p.Q562*|DDX20_uc001ebt.2_Nonsense_Mutation_p.Q408*	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	800					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGGAATGCTCAGAGACATCC	0.393													12	43					0	0	0.016723	0	0
ST7L	54879	broad.mit.edu	37	1	113124629	113124629	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:113124629G>A	uc001ecd.2	-	9	1359	c.1054C>T	c.(1054-1056)CTA>TTA	p.L352L	ST7L_uc009wgh.2_Intron|ST7L_uc001ecc.2_Silent_p.L169L|ST7L_uc010owg.1_Silent_p.L287L|ST7L_uc010owh.1_Intron|ST7L_uc001ece.2_Silent_p.L352L|ST7L_uc001ecf.2_Silent_p.L335L|ST7L_uc001ecg.2_RNA|ST7L_uc010owi.1_Silent_p.L287L|ST7L_uc001ech.2_Silent_p.L335L|ST7L_uc001eci.2_Silent_p.L352L|ST7L_uc009wgi.1_RNA|ST7L_uc010owj.1_Silent_p.L335L	NM_017744	NP_060214	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7-like isoform 1	352					negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TATTTTGCTAGGACTGCCTGA	0.323													5	27					0	0	0.001168	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	C	C	rs11554290		TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:115256529T>C	uc009wgu.2	-	3	436	c.182A>G	c.(181-183)CAA>CGA	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458	Q61L(HEPG2_LIVER)|Q61R(SKMEL2_SKIN)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MHHES1_BONE)|Q61R(HT1197_URINARY_TRACT)|Q61L(MELJUSO_SKIN)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(KU1919_URINARY_TRACT)|Q61L(C3A_LIVER)|Q61R(TT2609C02_THYROID)|Q61R(NCIH2347_LUNG)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(SW1271_LUNG)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			38	109					0	0	0.021022	0	0
NOTCH2	4853	broad.mit.edu	37	1	120458690	120458690	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:120458690G>A	uc001eik.2	-	34	6911	c.6655C>T	c.(6655-6657)CCC>TCC	p.P2219S		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	2219	Cytoplasmic (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTCACTGAGGGAAGCACAGTG	0.572			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				113	421					0	0	0.014410	0	0
ANKRD35	148741	broad.mit.edu	37	1	145561799	145561799	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:145561799G>A	uc001eob.1	+	10	1595	c.1487G>A	c.(1486-1488)AGG>AAG	p.R496K	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.R339K	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	496										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTTCAACTAAGGGAGGAGCTT	0.602													36	124					0	0	0.006230	0	0
CD160	11126	broad.mit.edu	37	1	145704307	145704307	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:145704307C>T	uc001eol.1	-	4	328	c.110G>A	c.(109-111)GGA>GAA	p.G37E	NBPF10_uc001emp.3_Intron|CD160_uc001eom.1_Intron|CD160_uc010oyz.1_Intron	NM_007053	NP_008984	O95971	BY55_HUMAN	CD160 antigen precursor	37	Ig-like V-type.				cell proliferation|cell surface receptor linked signaling pathway|cellular defense response|regulation of immune response	anchored to plasma membrane	MHC class I receptor activity|receptor binding				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TAGTCGCGTTCCTTCCTGGGA	0.458													5	36					0	0	0.001984	0	0
APH1A	51107	broad.mit.edu	37	1	150238977	150238977	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:150238977A>G	uc001ety.1	-	6	1011	c.689T>C	c.(688-690)ATC>ACC	p.I230T	APH1A_uc010pbx.1_Missense_Mutation_p.I160T|APH1A_uc001etz.1_Missense_Mutation_p.I230T|APH1A_uc001eua.1_Missense_Mutation_p.I230T|APH1A_uc010pby.1_Missense_Mutation_p.I173T|APH1A_uc001eub.1_Missense_Mutation_p.I114T|APH1A_uc010pbz.1_Missense_Mutation_p.I114T	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	230	Helical; Name=7; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCCAGCTGTGATGAAGGCCCA	0.562													5	31					0	0	0.014758	0	0
RPRD2	23248	broad.mit.edu	37	1	150444375	150444375	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:150444375C>T	uc009wlr.2	+	11	3152	c.2951C>T	c.(2950-2952)CCC>CTC	p.P984L	RPRD2_uc010pcc.1_Silent_p.S911S|RPRD2_uc001eup.3_Missense_Mutation_p.P958L	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	984							protein binding			ovary(1)	1						CTTGCCGCTCCCACGGGTCAC	0.547													52	233					0	0	0.014410	0	0
CRNN	49860	broad.mit.edu	37	1	152383215	152383215	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:152383215C>T	uc001ezx.2	-	3	417	c.343G>A	c.(343-345)GAA>AAA	p.E115K		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	115					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTGTCCTTCGCCCAGCTCC	0.617													44	230					0	0	0.014410	0	0
INTS3	65123	broad.mit.edu	37	1	153741373	153741373	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:153741373C>T	uc009wom.2	+	23	2470	c.2249C>T	c.(2248-2250)CCA>CTA	p.P750L	INTS3_uc001fct.2_Missense_Mutation_p.P750L|INTS3_uc001fcu.2_Missense_Mutation_p.P442L|INTS3_uc001fcv.2_Missense_Mutation_p.P544L|INTS3_uc010peb.1_Missense_Mutation_p.P544L|INTS3_uc001fcw.2_Missense_Mutation_p.P263L|INTS3_uc010pec.1_Missense_Mutation_p.P263L|INTS3_uc001fcy.2_Missense_Mutation_p.P47L|INTS3_uc001fcx.2_Missense_Mutation_p.P47L	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	751					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			ATTTAGTTTCCAGATGAAACC	0.483													4	28					0	0	0.009096	0	0
PBXIP1	57326	broad.mit.edu	37	1	154919184	154919184	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:154919184G>A	uc001ffr.2	-	10	1025	c.966C>T	c.(964-966)GCC>GCT	p.A322A	PBXIP1_uc001ffs.2_Silent_p.A293A|PBXIP1_uc010pep.1_Silent_p.A167A	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	322	Potential.				cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CCCGCTGGAAGGCTTCGCCCT	0.667													5	23					0	0	0.014758	0	0
SCAMP3	10067	broad.mit.edu	37	1	155228653	155228653	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:155228653G>A	uc001fjs.2	-	5	734	c.481C>T	c.(481-483)CAG>TAG	p.Q161*	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjr.2_Nonsense_Mutation_p.Q8*|SCAMP3_uc001fju.2_Nonsense_Mutation_p.Q147*|SCAMP3_uc001fjv.2_Nonsense_Mutation_p.Q161*|SCAMP3_uc001fjt.2_Nonsense_Mutation_p.Q135*	NM_005698	NP_005689	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3 isoform 1	161	Cytoplasmic (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane				ovary(3)	3	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			ACAGTCTTCTGAAATTCTTGG	0.493													24	152					0	0	0.018920	0	0
GON4L	54856	broad.mit.edu	37	1	155736235	155736235	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:155736235G>A	uc001flz.2	-	21	3126	c.3029C>T	c.(3028-3030)CCC>CTC	p.P1010L	GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Missense_Mutation_p.P1010L|GON4L_uc009wrh.1_Missense_Mutation_p.P1010L|GON4L_uc001fma.1_Missense_Mutation_p.P1010L|GON4L_uc001fmb.3_Missense_Mutation_p.P206L|GON4L_uc001fmc.2_Missense_Mutation_p.P1010L|GON4L_uc001fmd.3_Missense_Mutation_p.P1010L|GON4L_uc009wri.2_Missense_Mutation_p.P596L	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	1010					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CTGGAGAGAGGGGCTGGGTTG	0.557													17	75					0	0	0.006122	0	0
SMG5	23381	broad.mit.edu	37	1	156236056	156236056	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:156236056G>A	uc001foc.3	-	12	1520	c.1371C>T	c.(1369-1371)TCC>TCT	p.S457S	SMG5_uc009wrv.2_5'UTR	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	457					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					GGCGGAGACAGGAGAGGCGAG	0.587													28	98					0	0	0.006320	0	0
MEF2D	4209	broad.mit.edu	37	1	156437893	156437893	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:156437893G>A	uc001fpc.2	-	11	1836	c.1446C>T	c.(1444-1446)GAC>GAT	p.D482D	MEF2D_uc001fpb.2_Silent_p.D475D|MEF2D_uc001fpd.2_Silent_p.D475D|MEF2D_uc001fpe.1_Silent_p.D482D|MEF2D_uc009wsa.2_RNA	NM_005920	NP_005911	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	482					apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGTCATCCCGGTCTCCCGTCT	0.701													15	38					0	0	0.004007	0	0
CD1A	909	broad.mit.edu	37	1	158224917	158224917	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:158224917C>T	uc001frt.2	+	2	635	c.102C>T	c.(100-102)TCC>TCT	p.S34S		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	34	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GGATCGCATCCTTTTACAACC	0.478													14	98					0	0	0.020292	0	0
DCAF6	55827	broad.mit.edu	37	1	168012370	168012370	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:168012370G>A	uc001gew.2	+	12	1846	c.1604G>A	c.(1603-1605)AGT>AAT	p.S535N	DCAF6_uc001gev.2_Missense_Mutation_p.S555N|DCAF6_uc001gex.2_Missense_Mutation_p.S612N|DCAF6_uc010plk.1_Missense_Mutation_p.S581N|DCAF6_uc001gey.2_Missense_Mutation_p.S408N|DCAF6_uc001gez.2_Translation_Start_Site	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	535					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GAAGGAGACAGTGAAACAAGT	0.408													11	37					0	0	0.010729	0	0
C1orf114	57821	broad.mit.edu	37	1	169388387	169388387	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:169388387C>T	uc001gga.1	-	4	1247	c.1079G>A	c.(1078-1080)CGA>CAA	p.R360Q	C1orf114_uc001gfz.1_Missense_Mutation_p.R360Q|C1orf114_uc009wvq.1_Missense_Mutation_p.R360Q|C1orf114_uc001ggb.2_Missense_Mutation_p.R360Q	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	360	Potential.										0	all_hematologic(923;0.208)					TTCTATTTTTCGTCGCTCTTC	0.303													5	18					0	0	0.014758	0	0
SLC9A11	284525	broad.mit.edu	37	1	173567119	173567119	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:173567119G>A	uc001giz.2	-	4	704	c.281C>T	c.(280-282)TCT>TTT	p.S94F	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	94	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TGAAAAGTAAGAATAAAGTGA	0.308													6	51					0	0	0.001168	0	0
TNR	7143	broad.mit.edu	37	1	175335040	175335040	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:175335040C>T	uc001gkp.1	-	9	2369	c.2288G>A	c.(2287-2289)AGC>AAC	p.S763N	TNR_uc009wwu.1_Missense_Mutation_p.S763N	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	763	Fibronectin type-III 5.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GGACTCCAAGCTCTGCTGCCG	0.532													18	66					0	0	0.008871	0	0
FAM129A	116496	broad.mit.edu	37	1	184777223	184777223	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:184777223C>T	uc001gra.2	-	10	1514	c.1320G>A	c.(1318-1320)CAG>CAA	p.Q440Q	FAM129A_uc001grb.1_Silent_p.Q203Q|FAM129A_uc009wyh.1_Silent_p.Q268Q|FAM129A_uc009wyi.1_Silent_p.Q238Q	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	440					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						GCATGTAGTTCTGTGTCCTCT	0.537													29	126					0	0	0.010818	0	0
CHIT1	1118	broad.mit.edu	37	1	203186132	203186132	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:203186132G>A	uc001gzn.2	-	11	1382	c.1286C>T	c.(1285-1287)CCC>CTC	p.P429L	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_Intron|CHIT1_uc009xal.1_Missense_Mutation_p.P191L|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.P420L	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	429	Chitin-binding type-2.				chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						CCGAGGATTGGGATAGAGCCC	0.592											OREG0014113	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	104					0	0	0.004007	0	0
MFSD4	148808	broad.mit.edu	37	1	205554035	205554035	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:205554035G>A	uc001hcv.3	+	5	977	c.891G>A	c.(889-891)AGG>AGA	p.R297R	MFSD4_uc010prk.1_Silent_p.R210R|MFSD4_uc010prl.1_RNA|MFSD4_uc010prm.1_Silent_p.R242R	NM_181644	NP_857595	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing	297					transmembrane transport	integral to membrane				skin(2)|central_nervous_system(1)	3	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GCTGCCAAAGGAAGAACCTCA	0.587											OREG0014158	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	89					0	0	0.007291	0	0
VASH2	79805	broad.mit.edu	37	1	213146268	213146268	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:213146268G>A	uc001hjy.2	+	5	1048	c.844G>A	c.(844-846)GAG>AAG	p.E282K	VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Missense_Mutation_p.E217K|VASH2_uc010ptn.1_Missense_Mutation_p.E178K|VASH2_uc001hjw.2_Missense_Mutation_p.E238K	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3	282					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		CATAAGGAAGGAGCTGGAGAA	0.527													10	37					0	0	0.008291	0	0
PROX1	5629	broad.mit.edu	37	1	214171436	214171436	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:214171436G>A	uc001hkh.2	+	2	1830	c.1558G>A	c.(1558-1560)GAT>AAT	p.D520N	PROX1_uc001hkg.1_Missense_Mutation_p.D520N	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	520					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CTTAACTAGGGATACCACGAG	0.557													10	88					0	0	0.013537	0	0
USH2A	7399	broad.mit.edu	37	1	216465538	216465538	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:216465538C>T	uc001hku.1	-	10	2206	c.1819G>A	c.(1819-1821)GAT>AAT	p.D607N	USH2A_uc001hkv.2_Missense_Mutation_p.D607N	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	607	Laminin EGF-like 2.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGCTCACAATCATCACAAACT	0.403										HNSCC(13;0.011)			9	42					0	0	0.006214	0	0
OBSCN	84033	broad.mit.edu	37	1	228452073	228452073	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:228452073C>T	uc009xez.1	+	16	4886	c.4842C>T	c.(4840-4842)TCC>TCT	p.S1614S	OBSCN_uc001hsn.2_Silent_p.S1614S	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1614	Ig-like 16.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGCGGCTGTCCTTCCACCTGC	0.647													6	20					0	0	0.001168	0	0
GALNT2	2590	broad.mit.edu	37	1	230390970	230390970	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:230390970C>T	uc010pwa.1	+	11	1088	c.1016C>T	c.(1015-1017)TCG>TTG	p.S339L	GALNT2_uc010pvy.1_Missense_Mutation_p.S301L|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	339	Lumenal (Potential).|Catalytic subdomain B.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				TCAGAGATCTCGTTCCGCGTG	0.617													21	88					0	0	0.014323	0	0
TBCE	6905	broad.mit.edu	37	1	235577778	235577778	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:235577778G>A	uc001hwz.1	+	4	339	c.216G>A	c.(214-216)CCG>CCA	p.P72P	TBCE_uc010pxq.1_RNA|TBCE_uc001hxa.1_Silent_p.P72P|TBCE_uc010pxr.1_Silent_p.P72P|TBCE_uc001hxb.1_5'UTR	NM_003193	NP_003184	Q15813	TBCE_HUMAN	beta-tubulin cofactor E	72					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			TTATTCGTCCGAACAAGGTAA	0.383													7	62					0	0	0.004482	0	0
RYR2	6262	broad.mit.edu	37	1	237919588	237919588	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:237919588G>A	uc001hyl.1	+	81	11266	c.11146G>A	c.(11146-11148)GAA>AAA	p.E3716K	RYR2_uc010pya.1_Missense_Mutation_p.E131K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3716					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTGTGTTCAGGAAAAAGAAAT	0.443													4	34					0	0	0.014758	0	0
NLRP3	114548	broad.mit.edu	37	1	247588534	247588534	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:247588534A>C	uc001icr.2	+	5	1927	c.1789A>C	c.(1789-1791)AGT>CGT	p.S597R	NLRP3_uc001ics.2_Missense_Mutation_p.S597R|NLRP3_uc001icu.2_Missense_Mutation_p.S597R|NLRP3_uc001icw.2_Missense_Mutation_p.S597R|NLRP3_uc001icv.2_Missense_Mutation_p.S597R|NLRP3_uc010pyw.1_Missense_Mutation_p.S595R|NLRP3_uc001ict.1_Missense_Mutation_p.S595R	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	597					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GAAGAAATTAAGTTGCAAGAT	0.438													16	36					0	0	0.006122	0	0
OR2W5	441932	broad.mit.edu	37	1	247654770	247654770	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr1:247654770T>C	uc001icz.1	+	1	341	c.341T>C	c.(340-342)CTC>CCC	p.L114P		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GAGTGCGTCCTCCTGGTTGTC	0.602													10	63					0	0	0.008291	0	0
MPP7	143098	broad.mit.edu	37	10	28409131	28409131	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:28409131G>A	uc001iua.1	-	12	1283	c.879C>T	c.(877-879)TTC>TTT	p.F293F	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Silent_p.F293F|MPP7_uc009xla.2_Silent_p.F293F|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	293	SH3.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						ACCTTTCCTGGAAATGCTTTG	0.438													8	33					0	0	0.003080	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508025	37508025	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:37508025G>A	uc001iza.1	+	34	3316	c.3217G>A	c.(3217-3219)GAA>AAA	p.E1073K		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1129	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CCAGGAAAAGGAAAATAAATA	0.318													18	44					0	0	0.004990	0	0
PPYR1	5540	broad.mit.edu	37	10	47087209	47087209	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:47087209C>T	uc001jee.2	+	3	845	c.426C>T	c.(424-426)CTC>CTT	p.L142L	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.L142L	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	142	Cytoplasmic (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						GGCATCAGCTCATCATCAACC	0.592													17	128					0	0	0.007413	0	0
ANK3	288	broad.mit.edu	37	10	61835986	61835986	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:61835986G>A	uc001jky.2	-	37	4845	c.4653C>T	c.(4651-4653)TCC>TCT	p.S1551S	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1551	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CGCCTAATGTGGATTTGATTG	0.423													24	69					0	0	0.006320	0	0
TET1	80312	broad.mit.edu	37	10	70405330	70405330	+	Silent	SNP	A	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:70405330A>T	uc001jok.3	+	4	3349	c.2844A>T	c.(2842-2844)GGA>GGT	p.G948G		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	948					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						ACTTACAGGGAGAGCCACCAA	0.428													9	30					0	0	0.006214	0	0
TTC18	118491	broad.mit.edu	37	10	75090940	75090940	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:75090940C>T	uc009xrc.2	-	9	1103	c.982G>A	c.(982-984)GAA>AAA	p.E328K	TTC18_uc001jty.2_Missense_Mutation_p.E328K|TTC18_uc009xrd.1_Missense_Mutation_p.E136K	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	328							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					TTTACCTTTTCAGTTTTGCCA	0.403													5	18					0	0	0.001168	0	0
TTC18	118491	broad.mit.edu	37	10	75101312	75101312	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:75101312C>T	uc009xrc.2	-	7	758	c.637G>A	c.(637-639)GGA>AGA	p.G213R	TTC18_uc001jty.2_Missense_Mutation_p.G213R|TTC18_uc009xrd.1_Missense_Mutation_p.G21R	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	213							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					TTCAGAGTTCCATTCTTAAAT	0.413													12	44					0	0	0.016723	0	0
SEC24C	9632	broad.mit.edu	37	10	75519806	75519806	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:75519806G>A	uc001juw.2	+	6	691	c.512G>A	c.(511-513)GGA>GAA	p.G171E	SEC24C_uc010qkn.1_RNA|SEC24C_uc009xrj.1_Missense_Mutation_p.G29E|SEC24C_uc001jux.2_Missense_Mutation_p.G171E|SEC24C_uc010qko.1_Missense_Mutation_p.G29E|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	171					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					TCAGCCTCAGGAAGTTTCCCT	0.547													28	79					0	0	0.008361	0	0
SH2D4B	387694	broad.mit.edu	37	10	82369223	82369223	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:82369223A>T	uc001kck.1	+	6	1331	c.901A>T	c.(901-903)ATC>TTC	p.I301F	SH2D4B_uc001kcl.1_Missense_Mutation_p.I253F|SH2D4B_uc001kcm.1_Missense_Mutation_p.I48F	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	300											0			Colorectal(32;0.229)			CAGAGATGTCATCGTCCGCTG	0.582													9	39					0	0	0.006214	0	0
CYP2C18	1562	broad.mit.edu	37	10	96484139	96484139	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:96484139G>A	uc001kjv.3	+	7	1324	c.998G>A	c.(997-999)AGA>AAA	p.R333K	CYP2C18_uc001kjw.3_Missense_Mutation_p.R274K|CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_5'UTR	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	333					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GTAGTTGGCAGAAACCGGAGC	0.473													18	68					0	0	0.014323	0	0
SORBS1	10580	broad.mit.edu	37	10	97097017	97097017	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:97097017G>A	uc001kkp.2	-	28	2945	c.2900C>T	c.(2899-2901)CCC>CTC	p.P967L	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.P921L|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	967					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CAGAGATGAGGGGGCTGGCGT	0.428													3	15					0	0	0.004672	0	0
LOXL4	84171	broad.mit.edu	37	10	100017472	100017472	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:100017472C>T	uc001kpa.1	-	8	1346	c.1195G>A	c.(1195-1197)GGT>AGT	p.G399S		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	399	SRCR 3.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		TGTTGGCAACCATTCTGGGAC	0.587													22	56					0	0	0.014323	0	0
CNNM2	54805	broad.mit.edu	37	10	104809545	104809545	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:104809545C>T	uc001kwm.2	+	2	1827	c.1703C>T	c.(1702-1704)ACC>ATC	p.T568I	CNNM2_uc001kwn.2_Missense_Mutation_p.T568I	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	568	CBS 2.		T -> I (in HOMG6; reduced activity; electrophysiological analysis shows that magnesium-sensitive sodium currents are significantly diminished and are blocked by increased extracellular magnesium concentrations).		ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GGAATCGTCACCTTAGAAGAT	0.388													6	61					0	0	0.001168	0	0
FRG2B	441581	broad.mit.edu	37	10	135440242	135440242	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:135440242C>T	uc010qvg.1	-	1	58	c.5G>A	c.(4-6)GGA>GAA	p.G2E		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	2						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		ATTTCCCTTTCCCATGTTGAA	0.532													9	141					0	0	0.016723	0	0
CHID1	66005	broad.mit.edu	37	11	902963	902963	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr11:902963G>A	uc001lsl.2	-	3	421	c.260C>T	c.(259-261)CCA>CTA	p.P87L	CHID1_uc010qwu.1_Missense_Mutation_p.P117L|CHID1_uc010qwv.1_Missense_Mutation_p.P148L|CHID1_uc001lsn.2_Missense_Mutation_p.P112L|CHID1_uc001lsm.2_Missense_Mutation_p.P87L|CHID1_uc001lso.2_Missense_Mutation_p.P87L|CHID1_uc001lsp.2_Missense_Mutation_p.P87L|CHID1_uc010qww.1_Missense_Mutation_p.P87L	NM_023947	NP_076436	Q9BWS9	CHID1_HUMAN	chitinase domain containing 1 isoform a	87					chitin catabolic process|innate immune response	extracellular region|lysosome	cation binding|chitinase activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.48e-25)|Epithelial(43;3.75e-24)|BRCA - Breast invasive adenocarcinoma(625;4.65e-05)|Lung(200;0.0624)|LUSC - Lung squamous cell carcinoma(625;0.0735)		CCAACTTACTGGAGTGACATA	0.607													5	16					0	0	0.014758	0	0
ABCC8	6833	broad.mit.edu	37	11	17491762	17491762	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr11:17491762C>T	uc001mnc.2	-	3	424	c.298G>A	c.(298-300)GAA>AAA	p.E100K	ABCC8_uc010rcy.1_Missense_Mutation_p.E100K	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	100	Extracellular (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGGTGGGATTCGGTCACCCTG	0.527													70	188					0	0	0.014410	0	0
GLYATL2	219970	broad.mit.edu	37	11	58605793	58605793	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr11:58605793C>T	uc001nnd.3	-	3	258	c.127G>A	c.(127-129)GAG>AAG	p.E43K	GLYATL2_uc009ymq.2_Missense_Mutation_p.E43K	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	43						mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	ACCAGCACCTCCATGTTGAAA	0.443													8	38					0	0	0.004482	0	0
CTSW	1521	broad.mit.edu	37	11	65649973	65649973	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr11:65649973G>A	uc001ogc.1	+	5	556	c.514G>A	c.(514-516)GAT>AAT	p.D172N	CTSW_uc001ogb.1_Missense_Mutation_p.D172N	NM_001335	NP_001326	P56202	CATW_HUMAN	cathepsin W preproprotein	172					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.168)		CAGTTTCTGGGATTTTGTGGA	0.627													10	45					0	0	0.008291	0	0
FOLH1B	219595	broad.mit.edu	37	11	89424095	89424095	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr11:89424095G>A	uc001pda.2	+	11	1271	c.745G>A	c.(745-747)GAA>AAA	p.E249K		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	249					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						CAGTGTCTATGAAACATATGA	0.368													8	23					0	0	0.006214	0	0
GRIA4	2893	broad.mit.edu	37	11	105769117	105769117	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr11:105769117T>A	uc001pix.2	+	7	1295	c.849T>A	c.(847-849)GAT>GAA	p.D283E	GRIA4_uc001piu.1_Missense_Mutation_p.D283E|GRIA4_uc001piw.2_Missense_Mutation_p.D283E|GRIA4_uc009yxk.1_Missense_Mutation_p.D283E	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	283	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	AGAAACTAGATCAGAGAGAGT	0.343													6	19					0	0	0.001984	0	0
CBL	867	broad.mit.edu	37	11	119158644	119158644	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr11:119158644C>T	uc001pwe.2	+	12	2162	c.2024C>T	c.(2023-2025)TCT>TTT	p.S675F		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	675	Interaction with CD2AP.|Pro-rich.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		GCCATTTATTCTCTGGCTGCC	0.333									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				11	35					0	0	0.016723	0	0
OR8D1	283159	broad.mit.edu	37	11	124180174	124180174	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr11:124180174C>T	uc010sag.1	-	1	489	c.489G>A	c.(487-489)ATG>ATA	p.M163I		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		ACAGTTTCATCATGGCACTTG	0.468													4	14					0	0	0.014758	0	0
CHD4	1108	broad.mit.edu	37	12	6702357	6702357	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:6702357G>A	uc001qpo.2	-	17	2716	c.2552C>T	c.(2551-2553)TCC>TTC	p.S851F	CHD4_uc001qpn.2_Missense_Mutation_p.S844F|CHD4_uc001qpp.2_Missense_Mutation_p.S848F	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	851	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CAATTCATAGGATGTCAGCAG	0.468													6	51					0	0	0.001984	0	0
PEX5	5830	broad.mit.edu	37	12	7343061	7343061	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:7343061C>T	uc009zfu.1	+	3	668	c.88C>T	c.(88-90)CTT>TTT	p.L30F	PEX5_uc001qsw.2_Missense_Mutation_p.L30F|PEX5_uc010sgc.1_Missense_Mutation_p.L30F|PEX5_uc001qsu.2_Missense_Mutation_p.L30F|PEX5_uc010sgd.1_Missense_Mutation_p.L51F|PEX5_uc001qsv.2_Missense_Mutation_p.L30F	NM_001131026	NP_001124498	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5 isoform d	30					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			ovary(1)	1						GGACAAGGCCCTTCGGCAGGA	0.677													6	44					0	0	0.001984	0	0
CD163L1	283316	broad.mit.edu	37	12	7510023	7510023	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:7510023G>A	uc001qsy.2	-	19	4365	c.4339C>T	c.(4339-4341)CCT>TCT	p.P1447S	CD163L1_uc010sge.1_Missense_Mutation_p.P1457S	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1447	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TCAGAGGCAGGAAGAACTCCC	0.413													7	53					0	0	0.006214	0	0
CD163L1	283316	broad.mit.edu	37	12	7550931	7550931	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:7550931C>T	uc001qsy.2	-	7	1684	c.1658G>A	c.(1657-1659)TGG>TAG	p.W553*	CD163L1_uc010sge.1_Nonsense_Mutation_p.W563*	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	553	SRCR 5.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TTCACAGTCCCAGATATTTGA	0.403													9	64					0	0	0.006214	0	0
NANOG	79923	broad.mit.edu	37	12	7945552	7945552	+	Missense_Mutation	SNP	C	T	T	rs71445169		TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:7945552C>T	uc009zfy.1	+	2	374	c.158C>T	c.(157-159)CCT>CTT	p.P53L		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	53					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		ACAGTCTCTCCTCTTCCTTCC	0.363													8	75					0	0	0.004482	0	0
TAS2R31	259290	broad.mit.edu	37	12	11183905	11183905	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:11183905G>A	uc001qzo.1	-	1	102	c.30C>T	c.(28-30)TCC>TCT	p.S10S	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	10	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						CTACCACACTGGAAAAAATGA	0.289													7	37					0	0	0.004482	0	0
ETNK1	55500	broad.mit.edu	37	12	22796809	22796809	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:22796809G>A	uc001rft.2	+	2	558	c.536G>A	c.(535-537)CGA>CAA	p.R179Q	ETNK1_uc009ziz.2_Missense_Mutation_p.R179Q|ETNK1_uc001rfs.2_Missense_Mutation_p.R179Q	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	179					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						TTAGTCGATCGAGATGAGGAA	0.403													10	63					0	0	0.008291	0	0
PKP2	5318	broad.mit.edu	37	12	33003895	33003895	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:33003895G>A	uc001rlj.3	-	5	1298	c.1183C>T	c.(1183-1185)CGT>TGT	p.R395C	PKP2_uc001rlk.3_Missense_Mutation_p.R395C|PKP2_uc010skj.1_Missense_Mutation_p.R395C	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	395	ARM 2.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AGGATGCCACGAAGCTGGTTA	0.408													16	36					0	0	0.003163	0	0
ZNF641	121274	broad.mit.edu	37	12	48739160	48739160	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:48739160A>C	uc001rrn.1	-	4	581	c.416T>G	c.(415-417)ATG>AGG	p.M139R	ZNF641_uc001rro.1_Missense_Mutation_p.M125R|ZNF641_uc010sls.1_Intron	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641	139	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						GTTTTCCTGCATGACATATTC	0.527													17	51					0	0	0.006122	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54922055	54922055	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:54922055G>A	uc001sgc.3	+	22	2479	c.2400G>A	c.(2398-2400)CAG>CAA	p.Q800Q	NCKAP1L_uc010sox.1_Silent_p.Q342Q|NCKAP1L_uc010soy.1_Silent_p.Q750Q	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	800					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TGCTTAGACAGGCAAGCAGTG	0.532													50	107					0	0	0.014410	0	0
DNAJC14	85406	broad.mit.edu	37	12	56215836	56215836	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:56215836C>T	uc001shx.1	-	7	2238	c.2034G>A	c.(2032-2034)AAG>AAA	p.K678K	DNAJC14_uc001shu.1_Silent_p.K678K|DNAJC14_uc009zob.1_Silent_p.K678K	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	678					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						TGCTGTTGGGCTTAGAGGCTG	0.547													16	60					0	0	0.006122	0	0
PAH	5053	broad.mit.edu	37	12	103248959	103248959	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:103248959C>T	uc001tjq.1	-	7	1133	c.661G>A	c.(661-663)GAA>AAA	p.E221K	PAH_uc010swc.1_Missense_Mutation_p.E221K	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	221			E -> G (in PKU; haplotype 4).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	ATGTTATCTTCATGGAAGCCA	0.463													6	27					0	0	0.001984	0	0
NAA25	80018	broad.mit.edu	37	12	112499158	112499158	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:112499158G>A	uc001ttm.2	-	12	1204	c.1184C>T	c.(1183-1185)TCG>TTG	p.S395L	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.S367L|NAA25_uc009zwa.1_Missense_Mutation_p.S395L	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	395						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						TGTTGGTGTCGACAAAGGAAC	0.453													9	32					0	0	0.006214	0	0
RASAL1	8437	broad.mit.edu	37	12	113553569	113553569	+	Silent	SNP	A	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:113553569A>G	uc001tum.1	-	11	1167	c.874T>C	c.(874-876)TTG>CTG	p.L292L	RASAL1_uc010syp.1_Silent_p.L292L|RASAL1_uc001tul.2_Silent_p.L292L|RASAL1_uc001tun.1_Silent_p.L292L|RASAL1_uc010syq.1_Silent_p.L292L|RASAL1_uc001tuo.3_Silent_p.L292L|RASAL1_uc010syr.1_Silent_p.L292L	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	292					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						TCTTCCAGCAAAGCCAAGGGG	0.627													12	35					0	0	0.004007	0	0
KSR2	283455	broad.mit.edu	37	12	118293378	118293378	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:118293378G>A	uc001two.2	-	3	295	c.240C>T	c.(238-240)ATC>ATT	p.I80I		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	109					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCCGGGGGAGATTTCCTAGA	0.602													7	20					0	0	0.001984	0	0
DNAH10	196385	broad.mit.edu	37	12	124323032	124323032	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:124323032G>A	uc001uft.3	+	28	4603	c.4578G>A	c.(4576-4578)GTG>GTA	p.V1526V		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1526	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AAGACCCCGTGATCAAGAGGT	0.547													4	15					0	0	0.009096	0	0
TMEM132B	114795	broad.mit.edu	37	12	126128629	126128629	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:126128629A>G	uc001uhe.1	+	6	1438	c.1430A>G	c.(1429-1431)AAC>AGC	p.N477S	TMEM132B_uc001uhf.1_5'UTR	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	477	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AAGGTTTCCAACAACTGTGAT	0.448													8	24					0	0	0.004482	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138638	126138638	+	Silent	SNP	C	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:126138638C>A	uc001uhe.1	+	9	2627	c.2619C>A	c.(2617-2619)CCC>CCA	p.P873P	TMEM132B_uc001uhf.1_Silent_p.P385P	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	873	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CAAGCTTCCCCACTCAAGGGA	0.507													9	21					7.48243e-07	7.79178e-07	0.006214	1	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	A	A	rs12366766		TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:132547087G>A	uc001ujn.2	+	46	8210	c.8175G>A	c.(8173-8175)CAG>CAA	p.Q2725Q	EP400_uc001ujl.2_Silent_p.Q2724Q|EP400_uc001ujm.2_Silent_p.Q2644Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.289													4	37					0	0	0.009096	0	0
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	G	G	rs28513925	by1000genomes	TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr12:132547093A>G	uc001ujn.2	+	46	8216	c.8181A>G	c.(8179-8181)CAA>CAG	p.Q2727Q	EP400_uc001ujl.2_Silent_p.Q2726Q|EP400_uc001ujm.2_Silent_p.Q2646Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.294													3	36					0	0	0.004672	0	0
GJB2	2706	broad.mit.edu	37	13	20763697	20763697	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr13:20763697C>T	uc001umy.2	-	2	239	c.24G>A	c.(22-24)ACG>ACA	p.T8T		NM_004004	NP_003995	P29033	CXB2_HUMAN	gap junction protein beta 2	8	Cytoplasmic (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane					0		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		CCCCCAGGATCGTCTGCAGCG	0.512									Keratitis_Ichthyosis_and_Deafness_syndrome		OREG0022282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	52					0	0	0.020292	0	0
HSPH1	10808	broad.mit.edu	37	13	31715323	31715323	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr13:31715323G>A	uc001utj.2	-	13	2188	c.1790C>T	c.(1789-1791)CCT>CTT	p.P597L	HSPH1_uc001utk.2_Missense_Mutation_p.P553L|HSPH1_uc010aaw.2_Missense_Mutation_p.P556L|HSPH1_uc001utl.2_Missense_Mutation_p.P599L|HSPH1_uc010tds.1_Missense_Mutation_p.P521L	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	597					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		GGCTTCAATAGGCAGCTCAAC	0.353													12	46					0	0	0.013537	0	0
RXFP2	122042	broad.mit.edu	37	13	32366091	32366091	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr13:32366091G>A	uc001utt.2	+	15	1365	c.1294G>A	c.(1294-1296)GGA>AGA	p.G432R	RXFP2_uc010aba.2_Missense_Mutation_p.G391R	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	432	Helical; Name=1; (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TACCTGCTTTGGAAATCTTTT	0.373													5	41					0	0	0.001168	0	0
NBEA	26960	broad.mit.edu	37	13	36223797	36223797	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr13:36223797C>T	uc001uvb.2	+	51	7919	c.7713C>T	c.(7711-7713)TTC>TTT	p.F2571F	NBEA_uc010abi.2_Silent_p.F1227F|NBEA_uc010tee.1_Silent_p.F364F|NBEA_uc010tef.1_Silent_p.F364F|NBEA_uc001uvd.2_Silent_p.F149F	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2571						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AACAGTGTTTCCTTCCACAGA	0.418													32	146					0	0	0.017118	0	0
ALG5	29880	broad.mit.edu	37	13	37569629	37569629	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr13:37569629G>A	uc001uvy.2	-	2	238	c.171C>T	c.(169-171)CCC>CCT	p.P57P	ALG5_uc010teq.1_Silent_p.P57P|ALG5_uc010ter.1_RNA	NM_013338	NP_037470	Q9Y673	ALG5_HUMAN	dolichyl-phosphate beta-glucosyltransferase	57	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate beta-glucosyltransferase activity|oligosaccharyl transferase activity				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;5.79e-07)|Epithelial(112;1.81e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00785)|BRCA - Breast invasive adenocarcinoma(63;0.0127)|GBM - Glioblastoma multiforme(144;0.0472)		CCCATATGCTGGGTAAAGTTT	0.403													14	57					0	0	0.020292	0	0
FREM2	341640	broad.mit.edu	37	13	39343824	39343824	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr13:39343824G>A	uc001uwv.2	+	4	5829	c.5520G>A	c.(5518-5520)CGG>CGA	p.R1840R	FREM2_uc001uww.2_5'UTR	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1840	Calx-beta 1.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGCGAGTGCGGATCCTGAGTG	0.542													12	40					0	0	0.013537	0	0
IRS2	8660	broad.mit.edu	37	13	110436510	110436510	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr13:110436510C>T	uc001vqv.2	-	1	2405	c.1891G>A	c.(1891-1893)GAC>AAC	p.D631N		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	631					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			TCTCCGTAGTCCTCTGGGTAG	0.701													3	18					0	0	0.009096	0	0
OR4K17	390436	broad.mit.edu	37	14	20586336	20586336	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr14:20586336G>A	uc001vwo.1	+	1	771	c.771G>A	c.(769-771)AAG>AAA	p.K257K		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TAACCATTAAGAACCACTCTC	0.418													16	50					0	0	0.004990	0	0
NFATC4	4776	broad.mit.edu	37	14	24839583	24839583	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr14:24839583C>T	uc001wpc.2	+	2	1300	c.979C>T	c.(979-981)CCT>TCT	p.P327S	NFATC4_uc010tok.1_Missense_Mutation_p.P390S|NFATC4_uc010tol.1_Missense_Mutation_p.P390S|NFATC4_uc010alr.2_Missense_Mutation_p.P390S|NFATC4_uc010als.2_Missense_Mutation_p.P340S|NFATC4_uc010tom.1_Missense_Mutation_p.P340S|NFATC4_uc010ton.1_Missense_Mutation_p.P340S|NFATC4_uc010too.1_Missense_Mutation_p.P340S|NFATC4_uc010alt.2_Missense_Mutation_p.P359S|NFATC4_uc010top.1_Missense_Mutation_p.P359S|NFATC4_uc010toq.1_Missense_Mutation_p.P359S|NFATC4_uc010alu.2_Intron|NFATC4_uc010tor.1_Missense_Mutation_p.P327S|NFATC4_uc010tos.1_Missense_Mutation_p.P257S|NFATC4_uc010tot.1_Missense_Mutation_p.P315S|NFATC4_uc010tou.1_Missense_Mutation_p.P257S|NFATC4_uc010tov.1_Missense_Mutation_p.P315S|NFATC4_uc010tow.1_Missense_Mutation_p.P257S|NFATC4_uc010alv.2_Missense_Mutation_p.P315S|NFATC4_uc010tox.1_Missense_Mutation_p.P257S|NFATC4_uc001wpd.2_5'Flank|NFATC4_uc010toy.1_5'Flank|NFATC4_uc010toz.1_5'Flank	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	327	Pro-rich.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		TGAGAGCATCCCTCAGAAGAC	0.662													6	27					0	0	0.001984	0	0
GZMB	3002	broad.mit.edu	37	14	25101557	25101557	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr14:25101557G>C	uc001wps.2	-	3	378	c.312C>G	c.(310-312)AAC>AAG	p.N104K	GZMB_uc010ama.2_Missense_Mutation_p.N92K|GZMB_uc010amb.2_Intron	NM_004131	NP_004122	P10144	GRAB_HUMAN	granzyme B precursor	104	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.028)		CGTTGGAGAAGTTCTTAGGAT	0.537													30	106					0	0	0.021022	0	0
PCNX	22990	broad.mit.edu	37	14	71575607	71575607	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr14:71575607C>T	uc001xmo.2	+	34	7034	c.6588C>T	c.(6586-6588)TCC>TCT	p.S2196S	PCNX_uc010are.1_Silent_p.S2085S|PCNX_uc010arf.1_Silent_p.S984S|PCNX_uc001xmp.2_Silent_p.S280S	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	2196	Ser-rich.					integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CCAGCAGCTCCAGCCAAAGCA	0.592													13	38					0	0	0.016723	0	0
NUMB	8650	broad.mit.edu	37	14	73783103	73783103	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr14:73783103C>T	uc001xny.1	-	6	549	c.229G>A	c.(229-231)GGA>AGA	p.G77R	NUMB_uc010aro.1_Missense_Mutation_p.G77R|NUMB_uc010arp.1_Intron|NUMB_uc010arq.1_Missense_Mutation_p.G77R|NUMB_uc010arr.1_Intron|NUMB_uc001xoa.1_Missense_Mutation_p.G77R|NUMB_uc001xnz.1_Intron|NUMB_uc001xob.1_Intron|NUMB_uc001xod.1_Missense_Mutation_p.G77R|NUMB_uc001xoc.1_Missense_Mutation_p.G77R|NUMB_uc010ars.1_Intron|NUMB_uc001xof.1_Intron|NUMB_uc001xog.2_Intron|NUMB_uc001xoh.1_Intron	NM_001005743	NP_001005743	P49757	NUMB_HUMAN	numb homolog isoform 1	77	PID.				axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				ovary(2)|central_nervous_system(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		CTTACTTTTCCAAAGAAGCCT	0.403													6	40					0	0	0.004482	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414195	105414195	+	Silent	SNP	G	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr14:105414195G>C	uc010axc.1	-	7	7713	c.7593C>G	c.(7591-7593)CTC>CTG	p.L2531L	AHNAK2_uc001ypx.2_Silent_p.L2431L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2531						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCTGAATGCTGAGGTCAGTGG	0.667													4	135					0	0	0.013537	0	0
RYR3	6263	broad.mit.edu	37	15	33961554	33961554	+	Splice_Site	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr15:33961554G>A	uc001zhi.2	+	37	5690	c.5620_splice	c.e37-1	p.I1874_splice	RYR3_uc010bar.2_Splice_Site_p.I1874_splice	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCCTCTCAAAGATCAACATGC	0.448													9	33					0	0	0.004482	0	0
IGDCC4	57722	broad.mit.edu	37	15	65682535	65682535	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr15:65682535G>A	uc002aou.1	-	13	2576	c.2366C>T	c.(2365-2367)CCC>CTC	p.P789L	IGDCC4_uc002aot.1_Missense_Mutation_p.P377L	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	789	Fibronectin type-III 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GAGCCCCCAGGGGCTGAAGCG	0.517													11	32					0	0	0.013537	0	0
STRA6	64220	broad.mit.edu	37	15	74481525	74481525	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr15:74481525C>T	uc002axk.2	-	12	1203	c.1021G>A	c.(1021-1023)GGA>AGA	p.G341R	STRA6_uc002axi.2_Missense_Mutation_p.G150R|STRA6_uc010ulh.1_Missense_Mutation_p.G379R|STRA6_uc002axj.2_Missense_Mutation_p.G380R|STRA6_uc010bji.2_Missense_Mutation_p.G341R|STRA6_uc002axl.2_Missense_Mutation_p.G273R|STRA6_uc002axm.2_Missense_Mutation_p.G341R|STRA6_uc002axn.2_Missense_Mutation_p.G332R|STRA6_uc010uli.1_Missense_Mutation_p.G378R|STRA6_uc010bjj.1_RNA	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	341	Helical; (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						AGCACGATTCCAAAGCCGGCC	0.642													6	16					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	15	82620400	82620400	+	RNA	SNP	T	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr15:82620400T>C	uc010bls.1	+	1		c.493T>C								Homo sapiens mRNA for FLJ00317 protein.																		GACCCAAGGGTCAGCCTGAGT	0.672													3	23					0	0	0.009096	0	0
MSLNL	401827	broad.mit.edu	37	16	830384	830384	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr16:830384G>A	uc002cjz.1	-	3	617	c.617C>T	c.(616-618)CCT>CTT	p.P206L		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:Variant_position_missing_in_Q96KJ4_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4						GGTGCATGCAGGCACGCACAT	0.597													10	51					0	0	0.006214	0	0
TMC5	79838	broad.mit.edu	37	16	19485449	19485449	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr16:19485449C>T	uc002dgc.3	+	12	2690	c.1941C>T	c.(1939-1941)TTC>TTT	p.F647F	TMC5_uc010vaq.1_Silent_p.F595F|TMC5_uc002dgb.3_Silent_p.F647F|TMC5_uc010var.1_Silent_p.F647F|TMC5_uc002dgd.1_Silent_p.F401F|TMC5_uc002dge.3_Silent_p.F401F|TMC5_uc002dgf.3_Silent_p.F330F|TMC5_uc002dgg.3_Silent_p.F288F	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	647	Extracellular (Potential).					integral to membrane				skin(1)	1						CCCTGCAGTTCCTGAAGACAC	0.522													25	106					0	0	0.009535	0	0
DNAH3	55567	broad.mit.edu	37	16	20999122	20999122	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr16:20999122C>T	uc010vbe.1	-	46	6775	c.6775G>A	c.(6775-6777)GTG>ATG	p.V2259M	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2259	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AAGTTCTCCACTGCATCTCTA	0.502													5	55					0	0	0.001168	0	0
EDC4	23644	broad.mit.edu	37	16	67910468	67910468	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr16:67910468C>G	uc002eur.2	+	3	483	c.317C>G	c.(316-318)TCT>TGT	p.S106C	EDC4_uc010cer.2_5'UTR|EDC4_uc010vkg.1_Missense_Mutation_p.S38C|EDC4_uc010ces.1_5'UTR|EDC4_uc002eus.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	106					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		AGCAGTGACTCTAGCATTTCA	0.527													3	37					0	0	0.014758	0	0
SMPD3	55512	broad.mit.edu	37	16	68405331	68405331	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr16:68405331C>T	uc002ewa.2	-	3	1176	c.754G>A	c.(754-756)GGC>AGC	p.G252S	SMPD3_uc010cfe.2_Missense_Mutation_p.G252S|SMPD3_uc010vlh.1_Missense_Mutation_p.G252S	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	252	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	GGCCGGCCGCCCTCCTCGCCA	0.711													4	20					0	0	0.009096	0	0
FBXO31	79791	broad.mit.edu	37	16	87364906	87364906	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr16:87364906G>A	uc002fjw.2	-	9	1652	c.1608C>T	c.(1606-1608)TCC>TCT	p.S536S	FBXO31_uc010vot.1_Silent_p.S364S|FBXO31_uc002fjv.2_Silent_p.S428S	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	536					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		AGGAGGTGAGGGACTGAATGT	0.582													8	22					0	0	0.003080	0	0
TP53	7157	broad.mit.edu	37	17	7578555	7578555	+	Splice_Site	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:7578555C>T	uc002gim.2	-	5	570	c.376_splice	c.e5-1	p.Y126_splice	TP53_uc002gig.1_Splice_Site_p.Y126_splice|TP53_uc002gih.2_Splice_Site_p.Y126_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Splice_Site_p.Y126_splice|TP53_uc010cni.1_Splice_Site_p.Y126_splice|TP53_uc002gij.2_Splice_Site_p.Y126_splice|TP53_uc010cnj.1_Splice_Site|TP53_uc002gin.2_Splice_Site_p.Y33_splice|TP53_uc002gio.2_Splice_Site|TP53_uc010vug.1_Splice_Site_p.Y87_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(31)|p.0?(7)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGGAGTACTGTAGGAAGA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	11					0	0	0.001168	0	0
MYH2	4620	broad.mit.edu	37	17	10447086	10447086	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:10447086G>A	uc010coi.2	-	8	811	c.683C>T	c.(682-684)CCC>CTC	p.P228L	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.P228L|MYH2_uc010coj.2_Missense_Mutation_p.P228L	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	228	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTCCAGTAGGGGGTTGGCACT	0.522													13	40					0	0	0.016723	0	0
AP2B1	163	broad.mit.edu	37	17	33977562	33977562	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:33977562C>T	uc002hjr.2	+	13	1739	c.1550C>T	c.(1549-1551)CCT>CTT	p.P517L	AP2B1_uc002hjq.2_Missense_Mutation_p.P517L|AP2B1_uc010wci.1_Missense_Mutation_p.P479L|AP2B1_uc002hjs.2_Missense_Mutation_p.P460L|AP2B1_uc002hjt.2_Missense_Mutation_p.P517L|AP2B1_uc010ctv.2_Missense_Mutation_p.P517L|AP2B1_uc010wcj.1_Missense_Mutation_p.P254L	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	517					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity	p.P517R(1)		ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TCTGATAATCCTGACCTTCGA	0.443													28	94					0	0	0.009535	0	0
GPR179	440435	broad.mit.edu	37	17	36482779	36482780	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:36482779_36482780CC>TT	uc002hpz.2	-	11	6693_6694	c.6672_6673GG>AA	c.(6670-6675)TGGGAA>TGAAAA	p.2224_2225WE>*K		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	2224_2225	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TCTGTGATTTCCCATTGGCACA	0.554													11	65					0	0	0.004672	0	0
KRT26	353288	broad.mit.edu	37	17	38926324	38926324	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:38926324C>T	uc002hvf.2	-	4	778	c.732G>A	c.(730-732)ATG>ATA	p.M244I		NM_181539	NP_853517	Q7Z3Y9	K1C26_HUMAN	keratin 26	244	Rod.|Linker 12.					intermediate filament	structural molecule activity				0		Breast(137;0.00526)				GGGTTGCATTCATCTCCACGT	0.483													22	67					0	0	0.012319	0	0
KRTAP3-2	83897	broad.mit.edu	37	17	39156052	39156052	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:39156052G>A	uc002hvs.2	-	1	87	c.54C>T	c.(52-54)ACC>ACT	p.T18T		NM_031959	NP_114165	Q9BYR7	KRA32_HUMAN	keratin associated protein 3.2	18	3 X 5 AA repeats of C-C-X(3).					keratin filament	structural molecule activity				0		Breast(137;0.00043)				AGGAGCAGATGGTGGTGGCAG	0.572													18	49					0	0	0.006122	0	0
JUP	3728	broad.mit.edu	37	17	39921203	39921203	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:39921203G>A	uc002hxq.2	-	6	1303	c.1026C>T	c.(1024-1026)CCC>CCT	p.P342P	JUP_uc010wfs.1_Intron|JUP_uc002hxr.2_Silent_p.P342P|JUP_uc002hxs.2_Silent_p.P342P	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	342	ARM 4.				adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GCTTATTGCTGGGACACACGG	0.592													25	80					0	0	0.004656	0	0
KCNH4	23415	broad.mit.edu	37	17	40327750	40327750	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:40327750G>A	uc002hzb.2	-	6	1167	c.834C>T	c.(832-834)ATC>ATT	p.I278I		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	278	Helical; Name=Segment S2; (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGTTCAGGATGATATCTGGGG	0.562													9	100					0	0	0.004482	0	0
OSBPL7	114881	broad.mit.edu	37	17	45891179	45891179	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:45891179G>A	uc002ilx.1	-	15	1576	c.1373C>T	c.(1372-1374)CCC>CTC	p.P458L	OSBPL7_uc002ilw.1_Missense_Mutation_p.P20L	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	458					lipid transport		lipid binding				0						TGGCCCCATGGGTCTCCCTGG	0.682													7	18					0	0	0.004482	0	0
SCRN2	90507	broad.mit.edu	37	17	45915274	45915274	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:45915274G>A	uc002imd.2	-	8	1340	c.1214C>T	c.(1213-1215)CCC>CTC	p.P405L	SCRN2_uc002imc.2_Missense_Mutation_p.P413L|SCRN2_uc002imf.2_3'UTR|SCRN2_uc002ime.2_RNA	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	secernin 2 isoform 1	405					proteolysis		dipeptidase activity			ovary(1)	1						CTCCCAGAGGGGTGGGGCCCA	0.662													5	28					0	0	0.001984	0	0
EPN3	55040	broad.mit.edu	37	17	48617661	48617661	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:48617661C>T	uc002ira.3	+	6	1380	c.945C>T	c.(943-945)TCC>TCT	p.S315S	SPATA20_uc002irc.2_5'Flank|EPN3_uc010wms.1_Silent_p.S343S|EPN3_uc010wmt.1_Intron|EPN3_uc010wmu.1_Silent_p.S288S	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	315						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CCCCGCCCTCCACACACTGCT	0.657													5	35					0	0	0.001984	0	0
MTMR4	9110	broad.mit.edu	37	17	56573397	56573397	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:56573397G>A	uc002iwj.2	-	16	2216	c.2106C>T	c.(2104-2106)TAC>TAT	p.Y702Y		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	702						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TAAGCAGTTTGTAACTTGGAG	0.483													26	202					0	0	0.007291	0	0
MTMR4	9110	broad.mit.edu	37	17	56581150	56581150	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:56581150G>A	uc002iwj.2	-	15	1876	c.1766C>T	c.(1765-1767)TCC>TTC	p.S589F		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	589						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGCCACTGGGGAAAGGTAAAG	0.527													25	82					0	0	0.021523	0	0
PPM1E	22843	broad.mit.edu	37	17	57046945	57046946	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:57046945_57046946GG>AA	uc002iwx.2	+	4	956_957	c.829_830GG>AA	c.(829-831)GGA>AAA	p.G277K	PPM1E_uc010ddd.2_Missense_Mutation_p.G40K	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	286	PP2C-like.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			TGGCCATGGGGGAGTAGATGCT	0.495													11	58					0	0	0.004672	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60351423	60351423	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:60351423G>A	uc002izq.2	-	2	166	c.54C>T	c.(52-54)ATC>ATT	p.I18I	TBC1D3P2_uc010woz.1_RNA					SubName: Full=Putative uncharacterized protein TBC1D3E;												0						ATTTCATAATGATGTCCTCTC	0.532													35	243					0	0	0.021022	0	0
KPNA2	3838	broad.mit.edu	37	17	66040459	66040459	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:66040459A>C	uc002jgk.2	+	9	1319	c.1187A>C	c.(1186-1188)GAA>GCA	p.E396A	KPNA2_uc002jgl.2_Missense_Mutation_p.E396A	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	396	NLS binding site (minor) (By similarity).|ARM 8.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			ACACAAAAGGAAGCTGTGTGG	0.378													35	103					0	0	0.005524	0	0
RNF157	114804	broad.mit.edu	37	17	74163764	74163764	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr17:74163764C>T	uc002jqz.2	-	4	480	c.411G>A	c.(409-411)CAG>CAA	p.Q137Q	RNF157_uc002jra.2_Silent_p.Q137Q	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	137							zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			CTTCCGTGGCCTGGTAATAGA	0.498													7	73					0	0	0.001984	0	0
TAF4B	6875	broad.mit.edu	37	18	23873455	23873455	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr18:23873455C>T	uc002kvu.3	+	9	2281	c.1792C>T	c.(1792-1794)CAG>TAG	p.Q598*	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Nonsense_Mutation_p.Q603*	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	598					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			ATCTCCTACTCAGAAAAATAG	0.274													4	19					0	0	0.014758	0	0
DSG2	1829	broad.mit.edu	37	18	29102104	29102104	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr18:29102104G>A	uc002kwu.3	+	6	770	c.582G>A	c.(580-582)TCG>TCA	p.S194S		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	194	Extracellular (Potential).|Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			CCCTGAATTCGAAAATTTCCT	0.368													5	25					0	0	0.001168	0	0
HDHD2	84064	broad.mit.edu	37	18	44656625	44656625	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr18:44656625G>A	uc002lcs.2	-	4	518	c.385C>T	c.(385-387)CAA>TAA	p.Q129*	HDHD2_uc002lct.2_Nonsense_Mutation_p.Q39*	NM_032124	NP_115500	Q9H0R4	HDHD2_HUMAN	haloacid dehalogenase-like hydrolase domain	129							hydrolase activity				0						CGGAATGCTTGATTCAGAATT	0.348													12	54					0	0	0.010729	0	0
LONP1	9361	broad.mit.edu	37	19	5705925	5705925	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:5705925G>A	uc002mcx.2	-	8	1258	c.1225C>T	c.(1225-1227)CTG>TTG	p.L409L	LONP1_uc002mcy.2_Silent_p.L345L|LONP1_uc010duh.2_Silent_p.L150L|LONP1_uc010dui.2_Silent_p.L393L|LONP1_uc002mcz.2_Silent_p.L213L	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	409					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						TCCTTCTCCAGGCCCAGCTCC	0.577													14	77					0	0	0.004990	0	0
C3	718	broad.mit.edu	37	19	6702496	6702496	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:6702496C>T	uc002mfm.2	-	18	2402	c.2340G>A	c.(2338-2340)GAG>GAA	p.E780E		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	780					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TTTTCGGTGGCTCTTTCAAGT	0.527													16	72					0	0	0.004990	0	0
MUC16	94025	broad.mit.edu	37	19	9018453	9018453	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:9018453C>T	uc002mkp.2	-	24	37925	c.37721G>A	c.(37720-37722)AGG>AAG	p.R12574K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12576	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGCAGGACCCTCTCAGTGGT	0.547													21	94					0	0	0.016522	0	0
ZNF560	147741	broad.mit.edu	37	19	9578257	9578257	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:9578257C>T	uc002mlp.1	-	10	1576	c.1366G>A	c.(1366-1368)GGA>AGA	p.G456R	ZNF560_uc010dwr.1_Missense_Mutation_p.G350R	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						GGCTTCTCTCCATTATGAACT	0.398													33	174					0	0	0.017118	0	0
MRPL4	51073	broad.mit.edu	37	19	10367430	10367430	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:10367430G>A	uc002mnm.2	+	6	528	c.374G>A	c.(373-375)CGG>CAG	p.R125Q	MRPL4_uc002mnn.2_Missense_Mutation_p.R125Q|MRPL4_uc002mno.2_Missense_Mutation_p.R125Q	NM_146387	NP_666499	Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4 isoform a	125					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		GGCGGTGGCCGGAAGCCTTGG	0.687													4	106					0	0	0.009096	0	0
LPPR2	64748	broad.mit.edu	37	19	11474874	11474875	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:11474874_11474875GG>AA	uc002mre.1	+	9	1322_1323	c.985_986GG>AA	c.(985-987)GGC>AAC	p.G329N	LPPR2_uc002mrf.1_Missense_Mutation_p.R309Q|LPPR2_uc010dxy.1_Missense_Mutation_p.R141Q	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	329						integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						ACACCGGCACGGCTCACCCCAT	0.644													13	95					0	0	0.004672	0	0
PDE4C	5143	broad.mit.edu	37	19	18333100	18333100	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:18333100C>T	uc010xqc.1	-	2	756	c.276G>A	c.(274-276)AGG>AGA	p.R92R	PDE4C_uc002nik.3_Silent_p.R92R|PDE4C_uc002nil.3_Silent_p.R92R|PDE4C_uc002nif.3_5'Flank|PDE4C_uc002nig.3_5'Flank|PDE4C_uc002nih.3_5'Flank|PDE4C_uc010ebk.2_5'UTR|PDE4C_uc002nii.3_Silent_p.R60R|PDE4C_uc010ebl.2_5'UTR|PDE4C_uc010xqd.1_5'UTR|PDE4C_uc010ebm.1_5'Flank|PDE4C_uc002nim.1_Silent_p.R92R	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	92					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	CCAGGGCCCTCCTCCCACACG	0.632													11	60					0	0	0.020292	0	0
SBSN	374897	broad.mit.edu	37	19	36017757	36017757	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:36017757G>A	uc002oae.1	-	2	468	c.398C>T	c.(397-399)GCG>GTG	p.A133V	SBSN_uc002oad.1_Missense_Mutation_p.A476V	NM_198538	NP_940940	Q6UWP8	SBSN_HUMAN	suprabasin isoform 2 precursor	133	Ala/Gly/His-rich.					extracellular region				ovary(1)	1	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCCTTGGACCGCTTTGTCTGC	0.607													12	16					0	0	0.013537	0	0
NPHS1	4868	broad.mit.edu	37	19	36330278	36330278	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:36330278G>A	uc002oby.2	-	22	2970	c.2970C>T	c.(2968-2970)GTC>GTT	p.V990V	NPHS1_uc010eem.1_RNA	NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	990	Fibronectin type-III.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGGGTGGTACGACATCCACAT	0.582													14	38					0	0	0.020292	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38673292	38673292	+	Nonsense_Mutation	SNP	A	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:38673292A>T	uc002ohk.2	+	16	4851	c.4342A>T	c.(4342-4344)AAG>TAG	p.K1448*		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1448					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CTTCTTCTCCAAGCAGCCTGT	0.607													15	76					0	0	0.020292	0	0
PRX	57716	broad.mit.edu	37	19	40902620	40902620	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:40902620G>C	uc002onr.2	-	7	1908	c.1639C>G	c.(1639-1641)CAG>GAG	p.Q547E	PRX_uc002onq.2_Missense_Mutation_p.Q408E|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	547	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].|18.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TTCGGCAGCTGTACCTCTGGA	0.587													3	138					0	0	0.004672	0	0
PSG8	440533	broad.mit.edu	37	19	43268068	43268068	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:43268068G>A	uc002ouo.2	-	2	528	c.430C>T	c.(430-432)CTG>TTG	p.L144L	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Silent_p.L144L|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_Missense_Mutation_p.P19S|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Silent_p.L144L|PSG8_uc002oum.3_Missense_Mutation_p.P144S|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.P144S	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	144	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				AATCACTCACGATATAAGGTG	0.498													29	169					0	0	0.017118	0	0
ZNF229	7772	broad.mit.edu	37	19	44932791	44932791	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:44932791C>T	uc002oze.1	-	6	2599	c.2165G>A	c.(2164-2166)AGA>AAA	p.R722K	ZNF229_uc010ejk.1_Missense_Mutation_p.R376K|ZNF229_uc010ejl.1_Missense_Mutation_p.R716K	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	722	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				TGAGCCATATCTGAAACCCTT	0.498													12	41					0	0	0.010729	0	0
TOMM40	10452	broad.mit.edu	37	19	45406309	45406309	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:45406309C>T	uc002ozx.3	+	10	1070	c.969C>T	c.(967-969)ATC>ATT	p.I323I	TOMM40_uc002ozy.3_Silent_p.I323I|TOMM40_uc002paa.3_Silent_p.I323I|TOMM40_uc002ozz.2_3'UTR|APOE_uc002pab.2_5'Flank	NM_006114	NP_006105	O96008	TOM40_HUMAN	translocase of outer mitochondrial membrane 40	323					protein targeting to mitochondrion	integral to membrane of membrane fraction|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex|pore complex	porin activity|protein transmembrane transporter activity|voltage-gated anion channel activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)			OV - Ovarian serous cystadenocarcinoma(262;0.0033)|Epithelial(262;0.176)		GCAACTGGATCGTGGGTGCCA	0.587													25	86					0	0	0.004656	0	0
PNMAL2	57469	broad.mit.edu	37	19	46997520	46997520	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:46997520G>A	uc002pes.2	-	1	1650	c.1203C>T	c.(1201-1203)GTC>GTT	p.V401V	uc002peu.1_5'Flank	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	401										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CCTTGCGCAGGACCACGGCGT	0.677													6	23					0	0	0.001168	0	0
POLD1	5424	broad.mit.edu	37	19	50902643	50902643	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:50902643C>T	uc002psb.3	+	3	274	c.218C>T	c.(217-219)TCA>TTA	p.S73L	POLD1_uc002psc.3_Missense_Mutation_p.S73L|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.S73L	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	73					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		GTCCCACCATCAGCCATAGAT	0.592								DNA_polymerases_(catalytic_subunits)					8	28					0	0	0.006214	0	0
ZNF175	7728	broad.mit.edu	37	19	52090840	52090840	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:52090840A>T	uc002pxb.2	+	5	1634	c.1256A>T	c.(1255-1257)TAT>TTT	p.Y419F		NM_007147	NP_009078	Q9Y473	ZN175_HUMAN	zinc finger protein 175	419	C2H2-type 6.				response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		GAGAGACAGTATGCATGCAGT	0.438													7	33					0	0	0.001984	0	0
FPR3	2359	broad.mit.edu	37	19	52327094	52327094	+	Silent	SNP	A	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:52327094A>G	uc002pxt.1	+	2	277	c.93A>G	c.(91-93)CTA>CTG	p.L31L		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	31	Helical; Name=1; (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						TCTCATTGCTAGTCCACGGAG	0.542													11	49					0	0	0.008291	0	0
ZNF701	55762	broad.mit.edu	37	19	53086410	53086410	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:53086410T>A	uc002pzs.1	+	4	1225	c.1098T>A	c.(1096-1098)GAT>GAA	p.D366E	ZNF701_uc010ydn.1_Missense_Mutation_p.D432E	NM_018260	NP_060730	Q9NV72	ZN701_HUMAN	zinc finger protein 701	366	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		TCAGACGTGATTCACACCTGG	0.398													7	46					0	0	0.004482	0	0
MIR526B	574468	broad.mit.edu	37	19	54197692	54197692	+	RNA	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:54197692G>A	hsa-mir-526b|MI0003150	+			c.46G>A			MIR519B_hsa-mir-519b|MI0003151_5'Flank																	0						TTGTCTGAAAGAAGAGAAAGT	0.413													9	39					0	0	0.010729	0	0
NLRP8	126205	broad.mit.edu	37	19	56473543	56473543	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:56473543C>T	uc002qmh.2	+	4	2224	c.2153C>T	c.(2152-2154)CCT>CTT	p.P718L	NLRP8_uc010etg.2_Missense_Mutation_p.P718L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	718						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TTGGGGCCTCCTTTTTTGAAG	0.488													14	58					0	0	0.020292	0	0
ZIM3	114026	broad.mit.edu	37	19	57646858	57646858	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr19:57646858C>T	uc002qnz.1	-	5	1233	c.847G>A	c.(847-849)GAA>AAA	p.E283K		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	283	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTCTCACATTCATTACACTGA	0.383													19	86					0	0	0.008871	0	0
FAM179A	165186	broad.mit.edu	37	2	29256361	29256361	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:29256361C>T	uc010ezl.2	+	16	2508	c.2157C>T	c.(2155-2157)CCC>CCT	p.P719P	FAM179A_uc010ymm.1_Silent_p.P664P|FAM179A_uc002rmr.3_Silent_p.P246P|FAM179A_uc002rms.1_Silent_p.P17P	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	719							binding			ovary(3)|skin(1)	4						ATGAACTTCCCTCTGCCAAAG	0.517													4	13					0	0	0.009096	0	0
CAPN13	92291	broad.mit.edu	37	2	31010176	31010176	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:31010176C>T	uc002rnn.2	-	2	192	c.16G>A	c.(16-18)GAG>AAG	p.E6K	CAPN13_uc002rnp.1_Missense_Mutation_p.E6K	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	6					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					ACTGAAGGCTCCTGGTAATAC	0.502													4	9					0	0	0.014758	0	0
Unknown	0	broad.mit.edu	37	2	91679135	91679135	+	RNA	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:91679135G>A	uc010yua.1	+	1		c.49G>A								Homo sapiens clone CIC 03 anticardiolipin immunoglobulin light chain mRNA, partial cds.																		ATCTGTAGGAGACAGAGTCAC	0.443													7	225					0	0	0.016723	0	0
TSGA10	80705	broad.mit.edu	37	2	99725886	99725886	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:99725886G>A	uc002szg.3	-	4	645	c.17C>T	c.(16-18)TCT>TTT	p.S6F	TSGA10_uc002szh.3_Missense_Mutation_p.S6F|TSGA10_uc002szi.3_Missense_Mutation_p.S6F|TSGA10_uc010fin.1_Missense_Mutation_p.S6F|TSGA10_uc010yvn.1_Missense_Mutation_p.S6F	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	6					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						TGGACTTTTAGACCTACTTCG	0.398													12	41					0	0	0.016723	0	0
TBC1D8	11138	broad.mit.edu	37	2	101652558	101652558	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:101652558G>A	uc010fiv.2	-	9	1611	c.1480C>T	c.(1480-1482)CGC>TGC	p.R494C	TBC1D8_uc010yvw.1_Missense_Mutation_p.R509C|TBC1D8_uc002tau.3_Missense_Mutation_p.R251C	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	494					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						TTCTCTGTGCGAAACATACAC	0.468													20	122					0	0	0.010504	0	0
IL1RL1	9173	broad.mit.edu	37	2	102959872	102959872	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:102959872C>T	uc002tbu.1	+	8	1238	c.967C>T	c.(967-969)CCA>TCA	p.P323S	IL1RL1_uc010ywa.1_Missense_Mutation_p.P206S|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Missense_Mutation_p.P323S	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	323	Extracellular (Potential).				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TAGGAAAAATCCAAGTAAGGA	0.448													15	94					0	0	0.006122	0	0
PLGLA	285189	broad.mit.edu	37	2	107007416	107007416	+	RNA	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:107007416C>T	uc002tdp.2	+	3		c.265C>T				NR_003506				Homo sapiens plasminogen-like A (PLGLA), non-coding RNA.												0						GGGACGATGTCCAAAACAAAA	0.438													3	26					0	0	0.004672	0	0
RGPD4	285190	broad.mit.edu	37	2	108476251	108476251	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:108476251G>T	uc010ywk.1	+	12	1790	c.1708G>T	c.(1708-1710)GGC>TGC	p.G570C	RGPD4_uc002tdu.2_5'UTR|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	570					intracellular transport		binding			skin(2)	2						GGAAAAACATGGCCTTCAACC	0.323													5	59					0.000157383	0.000163047	0.003080	1	0
MARCO	8685	broad.mit.edu	37	2	119748183	119748183	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:119748183G>A	uc002tln.1	+	13	1214	c.1082G>A	c.(1081-1083)GGA>GAA	p.G361E	MARCO_uc010yyf.1_Missense_Mutation_p.G283E	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	361	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGACAGCAAGGAAGAAAAGGA	0.468													14	43					0	0	0.004990	0	0
NEB	4703	broad.mit.edu	37	2	152512945	152512945	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:152512945C>T	uc010fnx.2	-	49	6408	c.6217G>A	c.(6217-6219)GGG>AGG	p.G2073R		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2073					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACCATTTTCCCCTTCCCTTTT	0.368													11	73					0	0	0.013537	0	0
PLA2R1	22925	broad.mit.edu	37	2	160798661	160798661	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:160798661G>A	uc002ube.1	-	29	4361	c.4154C>T	c.(4153-4155)ACT>ATT	p.T1385I	PLA2R1_uc010zcp.1_Missense_Mutation_p.T1383I	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1385	Extracellular (Potential).				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CGCCTCTGCAGTGTGAATATC	0.259													7	35					0	0	0.006214	0	0
SCN3A	6328	broad.mit.edu	37	2	165994598	165994598	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:165994598G>A	uc002ucx.2	-	15	2674	c.2182C>T	c.(2182-2184)CCA>TCA	p.P728S	SCN3A_uc002ucy.2_Missense_Mutation_p.P679S|SCN3A_uc002ucz.2_Missense_Mutation_p.P679S|SCN3A_uc002uda.1_Missense_Mutation_p.P548S|SCN3A_uc002udb.1_Missense_Mutation_p.P548S	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	728						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TACCAGCATGGCGGACATTTC	0.348													12	29					0	0	0.016723	0	0
SCN2A	6326	broad.mit.edu	37	2	166245390	166245390	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:166245390G>A	uc002udc.2	+	27	5364	c.5074G>A	c.(5074-5076)GAT>AAT	p.D1692N	SCN2A_uc002udd.2_Missense_Mutation_p.D1692N|SCN2A_uc002ude.2_Missense_Mutation_p.D1692N	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1692	IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGTTGGGATCGATGACATGTT	0.448													24	149					0	0	0.004656	0	0
PDK1	5163	broad.mit.edu	37	2	173451010	173451010	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:173451010G>A	uc002uhr.2	+	9	1050	c.950G>A	c.(949-951)AGT>AAT	p.S317N	PDK1_uc010zdz.1_Missense_Mutation_p.S162N|PDK1_uc010zea.1_RNA|PDK1_uc002uhq.1_Missense_Mutation_p.S337N|PDK1_uc002uhs.2_Missense_Mutation_p.S317N|PDK1_uc010zeb.1_Missense_Mutation_p.S337N	NM_002610	NP_002601	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase 1 precursor	317	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(3)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.12)			CCTTAGATGAGTGACCGAGGA	0.453									Autosomal_Dominant_Polycystic_Kidney_Disease				4	41					0	0	0.009096	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173659880	173659880	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:173659880G>A	uc002uhv.3	+	2	380	c.193G>A	c.(193-195)GAA>AAA	p.E65K	RAPGEF4_uc002uhu.2_Missense_Mutation_p.E65K|RAPGEF4_uc010fqn.2_Missense_Mutation_p.E48K	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	65	cAMP 1.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TGAGAATCTGGAAAAGGGAAT	0.328													18	102					0	0	0.010504	0	0
TTN	7273	broad.mit.edu	37	2	179433796	179433797	+	Missense_Mutation	DNP	TG	CT	CT			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:179433796_179433797TG>CT	uc010zfg.1	-	275	69582_69583	c.69358_69359CA>AG	c.(69358-69360)CAG>AGG	p.Q23120R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Q16815R|TTN_uc010zfi.1_Missense_Mutation_p.Q16748R|TTN_uc010zfj.1_Missense_Mutation_p.Q16623R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24047							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCAGCAGTCTGGGCAGGAAGG	0.436													19	91					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179434480	179434480	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:179434480C>T	uc010zfg.1	-	275	68899	c.68675G>A	c.(68674-68676)GGA>GAA	p.G22892E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G16587E|TTN_uc010zfi.1_Missense_Mutation_p.G16520E|TTN_uc010zfj.1_Missense_Mutation_p.G16395E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23819							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTATTAATTCCTGTTGGTGG	0.373													10	49					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179441825	179441825	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:179441825C>T	uc010zfg.1	-	273	61757	c.61533G>A	c.(61531-61533)AAG>AAA	p.K20511K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.K14206K|TTN_uc010zfi.1_Silent_p.K14139K|TTN_uc010zfj.1_Silent_p.K14014K|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21438							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTTTCTCTCTTTTCAAGTA	0.423													14	61					0	0	0.016723	0	0
TTN	7273	broad.mit.edu	37	2	179606096	179606096	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:179606096G>A	uc010zfh.1	-	46	11575	c.11351C>T	c.(11350-11352)GCC>GTC	p.A3784V	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.A3717V|TTN_uc010zfj.1_Missense_Mutation_p.A3592V|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCAAAGATGGCAGGAAGCCC	0.458													35	125					0	0	0.017118	0	0
TTN	7273	broad.mit.edu	37	2	179616237	179616237	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:179616237C>T	uc002unb.2	-	46	11114	c.10890G>A	c.(10888-10890)AGG>AGA	p.R3630R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAACCTTTATCCTATCTTCTC	0.363													19	85					0	0	0.016522	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803196	185803196	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:185803196G>A	uc002uph.2	+	4	3667	c.3073G>A	c.(3073-3075)GCT>ACT	p.A1025T		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1025						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GCAAATCCTGGCTCCATTAGC	0.418													6	53					0	0	0.001168	0	0
SPEG	10290	broad.mit.edu	37	2	220350076	220350076	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:220350076G>A	uc010fwg.2	+	31	7618	c.7618G>A	c.(7618-7620)GAA>AAA	p.E2540K		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2540					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGCCCCAGGGGAAAGCCGAAG	0.607													10	80					0	0	0.013537	0	0
WDR69	164781	broad.mit.edu	37	2	228750084	228750084	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:228750084G>A	uc002vpn.1	+	2	137	c.58G>A	c.(58-60)GAA>AAA	p.E20K	WDR69_uc010zlw.1_Missense_Mutation_p.E5K|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	20										breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		GTTGGAATATGAAAAACATGG	0.338													8	54					0	0	0.008291	0	0
DNER	92737	broad.mit.edu	37	2	230231745	230231745	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:230231745G>A	uc002vpv.2	-	12	2093	c.1946C>T	c.(1945-1947)GCC>GTC	p.A649V		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	649	Helical; (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AAGGATGAAGGCCACGCAGAG	0.557													8	19					0	0	0.003080	0	0
HDAC4	9759	broad.mit.edu	37	2	239976470	239976470	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr2:239976470G>A	uc002vyk.3	-	25	3840	c.3048C>T	c.(3046-3048)TCC>TCT	p.S1016S	HDAC4_uc010fyy.2_Silent_p.S973S	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	1016	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CTTTCTCCATGGAACGGACAG	0.512													13	70					0	0	0.004990	0	0
PLCB1	23236	broad.mit.edu	37	20	8770195	8770195	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:8770195C>T	uc002wnb.2	+	30	3312	c.3309C>T	c.(3307-3309)ATC>ATT	p.I1103I	PLCB1_uc002wna.2_Silent_p.I1103I	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	1103					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GGTCATATATCCAGGAAGTGG	0.388													16	79					0	0	0.007413	0	0
HM13	81502	broad.mit.edu	37	20	30132785	30132785	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:30132785C>T	uc002wwe.2	+	4	515	c.401C>T	c.(400-402)CCA>CTA	p.P134L	HM13_uc002wwc.2_Missense_Mutation_p.P134L|HM13_uc002wwd.2_Missense_Mutation_p.P134L|HM13_uc002wwf.2_5'Flank|HM13_uc010gdu.2_5'Flank|PSIMCT-1_uc010gdt.2_5'Flank	NM_030789	NP_110416	Q8TCT9	HM13_HUMAN	minor histocompatibility antigen 13 isoform 1	134	Cytoplasmic (Potential).				membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)	1	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			GCCAGCTTTCCAAATCGACAG	0.512													8	51					0	0	0.003080	0	0
MYLK2	85366	broad.mit.edu	37	20	30407947	30407947	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:30407947C>T	uc002wwq.2	+	3	173	c.71C>T	c.(70-72)CCC>CTC	p.P24L		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	24					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CCTAAAGGTCCCACAGGTGAA	0.602													9	35					0	0	0.004482	0	0
SUN5	140732	broad.mit.edu	37	20	31585462	31585462	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:31585462C>T	uc002wyi.2	-	6	465	c.372G>A	c.(370-372)TCG>TCA	p.S124S		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	124					spermatogenesis					skin(1)	1						CTTTCATTTTCGATGGTAAGT	0.403													9	58					0	0	0.008291	0	0
FAM83D	81610	broad.mit.edu	37	20	37581057	37581058	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:37581057_37581058GG>AA	uc002xjg.2	+	4	1783_1784	c.1742_1743GG>AA	c.(1741-1743)AGG>AAA	p.R581K		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	551					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				ATGCTGTCAAGGAGAACACTCT	0.45													19	71					0	0	0.004672	0	0
WFDC9	259240	broad.mit.edu	37	20	44238797	44238797	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:44238797G>A	uc002xoy.2	-	3	242	c.24C>T	c.(22-24)CTC>CTT	p.L8L		NM_147198	NP_671731	Q8NEX5	WFDC9_HUMAN	protease inhibitor WAP9 precursor	8						extracellular region					0		Myeloproliferative disorder(115;0.0122)				TGAACATGACGAGTAGAAGAA	0.493													5	35					0	0	0.014758	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47611060	47611060	+	Missense_Mutation	SNP	G	A	A	rs149644732		TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:47611060G>A	uc002xtx.3	+	22	3198	c.3046G>A	c.(3046-3048)GGA>AGA	p.G1016R	ARFGEF2_uc010zyf.1_Missense_Mutation_p.G309R	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1016					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CTACCTGTCTGGATCTGGGCG	0.537													10	41					0	0	0.008291	0	0
SALL4	57167	broad.mit.edu	37	20	50407356	50407356	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:50407356C>T	uc002xwh.3	-	2	1767	c.1666G>A	c.(1666-1668)GAG>AAG	p.E556K	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	556					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TCAATGTTCTCCACCAACTGC	0.542													21	102					0	0	0.014323	0	0
SALL4	57167	broad.mit.edu	37	20	50407813	50407813	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:50407813G>A	uc002xwh.3	-	2	1310	c.1209C>T	c.(1207-1209)TCC>TCT	p.S403S	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	403	C2H2-type 1.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTCCAGTGTGGGAGCGGAGGT	0.542													9	38					0	0	0.006214	0	0
PCK1	5105	broad.mit.edu	37	20	56138106	56138106	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:56138106C>T	uc002xyn.3	+	5	796	c.633C>T	c.(631-633)CCC>CCT	p.P211P	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	211					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			ACAACTGGCCCTGCAACCCGG	0.632													10	53					0	0	0.008291	0	0
ZNF831	128611	broad.mit.edu	37	20	57829475	57829475	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr20:57829475G>A	uc002yan.2	+	5	4711	c.4711G>A	c.(4711-4713)GCT>ACT	p.A1571T		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1571						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TGAAATACCAGCTTCAGGACC	0.483													10	56					0	0	0.008291	0	0
TPTE	7179	broad.mit.edu	37	21	10942744	10942744	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr21:10942744C>T	uc002yip.1	-	13	1065	c.697G>A	c.(697-699)GAT>AAT	p.D233N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.D215N|TPTE_uc002yir.1_Missense_Mutation_p.D195N|TPTE_uc010gkv.1_Missense_Mutation_p.D95N	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	233	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCAAATCCATCCCTTGTGTAT	0.308													20	293					0	0	0.021523	0	0
TPTE	7179	broad.mit.edu	37	21	10998311	10998311	+	RNA	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr21:10998311C>T	uc002yis.1	-	11		c.1942G>A						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTCTGATTTTCCATCACAATC	0.363													10	61					0	0	0.008291	0	0
KRTAP19-8	728299	broad.mit.edu	37	21	32410639	32410639	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr21:32410639C>T	uc010glt.2	-	1	157	c.124G>A	c.(124-126)GGA>AGA	p.G42R		NM_001099219	NP_001092689	Q3LI54	KR198_HUMAN	keratin associated protein 19-8	42						intermediate filament				upper_aerodigestive_tract(1)	1						CCATAGCCTCCGTAGCCACAG	0.532													12	76					0	0	0.020292	0	0
MICAL3	57553	broad.mit.edu	37	22	18301315	18301315	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr22:18301315G>A	uc002zng.3	-	26	4465	c.4112C>T	c.(4111-4113)TCC>TTC	p.S1371F	MICAL3_uc011agl.1_Missense_Mutation_p.S1287F|MICAL3_uc010gre.1_5'Flank	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1371	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		ATCCTGGGGGGACTTTTCAAC	0.637													15	168					0	0	0.004007	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20131078	20131078	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr22:20131078C>T	uc002zrq.2	+	10	2031	c.1925C>T	c.(1924-1926)TCG>TTG	p.S642L	ZDHHC8_uc002zrr.1_Missense_Mutation_p.S642L|ZDHHC8_uc010gsa.2_Missense_Mutation_p.S448L	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	642	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					CCGCGGACGTCGTCCTCCTCC	0.721													4	5					0	0	0.009096	0	0
RGL4	266747	broad.mit.edu	37	22	24035163	24035163	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr22:24035163G>A	uc002zxn.2	+	3	1851	c.681G>A	c.(679-681)CTG>CTA	p.L227L	LOC91316_uc002zxh.3_RNA|LOC91316_uc002zxi.3_RNA|LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Silent_p.L227L|RGL4_uc002zxp.1_Silent_p.L91L|RGL4_uc002zxq.2_Silent_p.L91L	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	227	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						CAGAGCAGCTGACCCTCATGG	0.612													9	18					0	0	0.006214	0	0
ADRBK2	157	broad.mit.edu	37	22	26100117	26100117	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr22:26100117C>T	uc003abx.3	+	15	1416	c.1269C>T	c.(1267-1269)TCC>TCT	p.S423S	ADRBK2_uc010gux.2_Silent_p.S423S|ADRBK2_uc003abw.2_Silent_p.S310S|ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	423	Protein kinase.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	AACTGAAGTCCCTTTTGGAGG	0.498													9	36					0	0	0.010729	0	0
EWSR1	2130	broad.mit.edu	37	22	29694811	29694811	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr22:29694811C>T	uc003aet.2	+	14	1834	c.1506C>T	c.(1504-1506)CCC>CCT	p.P502P	EWSR1_uc003aev.2_Silent_p.P507P|EWSR1_uc003aew.2_Silent_p.P446P|EWSR1_uc003aex.2_Silent_p.P501P|EWSR1_uc003aey.2_Silent_p.P297P|EWSR1_uc003aez.2_Silent_p.P163P	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	502	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						CAAGAGGACCCCGGGGTTCCC	0.602			T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								13	97					0	0	0.003163	0	0
RFPL1	5988	broad.mit.edu	37	22	29837577	29837577	+	Silent	SNP	T	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr22:29837577T>A	uc003afn.2	+	2	629	c.420T>A	c.(418-420)ATT>ATA	p.I140I	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	140	B30.2/SPRY.						zinc ion binding				0						TCCTCCTCATTTCTGACGACC	0.512													19	58					0	0	0.012319	0	0
SEC14L4	284904	broad.mit.edu	37	22	30891916	30891916	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr22:30891916C>T	uc003aid.2	-	3	273	c.173G>A	c.(172-174)AGG>AAG	p.R58K	SEC14L4_uc011akz.1_Missense_Mutation_p.R58K|SEC14L4_uc003aie.2_Missense_Mutation_p.G27R|SEC14L4_uc003aif.2_Missense_Mutation_p.R4K	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a	58						integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	GATCCTTACCCTTCGGAGCAT	0.517													4	20					0	0	0.001168	0	0
MYH9	4627	broad.mit.edu	37	22	36698617	36698617	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr22:36698617G>A	uc003apg.2	-	20	2727	c.2496C>T	c.(2494-2496)ACC>ACT	p.T832T	MYH9_uc003aph.1_Silent_p.T696T	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	832					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CACGCACCTTGGTGAAGAGCC	0.368			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				15	48					0	0	0.004990	0	0
ENTHD1	150350	broad.mit.edu	37	22	40161538	40161538	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr22:40161538G>A	uc003ayg.2	-	6	1160	c.909C>T	c.(907-909)ATC>ATT	p.I303I		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	303										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					TATTTGTAAAGATACCATCTG	0.383													15	75					0	0	0.004990	0	0
MOV10L1	54456	broad.mit.edu	37	22	50580616	50580616	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr22:50580616G>T	uc003bjj.2	+	16	2260	c.2177G>T	c.(2176-2178)TGG>TTG	p.W726L	MOV10L1_uc003bjk.3_Missense_Mutation_p.W726L|MOV10L1_uc011arp.1_Missense_Mutation_p.W706L|MOV10L1_uc011arq.1_Missense_Mutation_p.W487L|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	726					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		ATGAGCGATTGGGGTATGTGC	0.542											OREG0026672	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	27					7.03913e-09	7.38742e-09	0.013537	1	0
CHL1	10752	broad.mit.edu	37	3	431047	431047	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:431047G>A	uc003bou.2	+	19	2583	c.2312G>A	c.(2311-2313)CGG>CAG	p.R771Q	CHL1_uc003bot.2_Missense_Mutation_p.R787Q|CHL1_uc003bow.1_Missense_Mutation_p.R771Q|CHL1_uc011asi.1_Missense_Mutation_p.R787Q	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	771	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CACACATTGCGGGTGATGACG	0.413													21	45					0	0	0.005443	0	0
ITPR1	3708	broad.mit.edu	37	3	4722316	4722316	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:4722316C>T	uc003bqa.2	+	25	3368	c.3020C>T	c.(3019-3021)TCC>TTC	p.S1007F	ITPR1_uc010hca.1_Missense_Mutation_p.S992F|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.S1001F|ITPR1_uc003bqc.2_5'Flank	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	1016	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GAAAGCAATTCCCAGACTTCA	0.413													9	37					0	0	0.006214	0	0
VHL	7428	broad.mit.edu	37	3	10191497	10191497	+	Nonsense_Mutation	SNP	C	T	T	rs5030819		TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:10191497C>T	uc003bvc.2	+	3	703	c.490C>T	c.(490-492)CAG>TAG	p.Q164*	VHL_uc003bvd.2_Nonsense_Mutation_p.Q123*	NM_000551	NP_000542	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor isoform 1	164	Interaction with Elongin BC complex.		Q -> R (in VHLD; type II).|Q -> H (in VHLD).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.Q164*(4)|p.Q164P(3)|p.Q164H(3)|p.Q164fs*9(1)|p.Q164R(1)|p.L158fs*6(1)|p.Q164fs*10(1)|p.Q164L(1)		kidney(1273)|soft_tissue(24)|adrenal_gland(15)|large_intestine(13)|pancreas(5)|endometrium(4)|thyroid(3)|upper_aerodigestive_tract(3)|central_nervous_system(2)|lung(2)|pleura(1)|paratesticular_tissues(1)	1346				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		GCGATGCCTCCAGGTTGTCCG	0.502		1	D|Mis|N|F|S		renal|hemangioma|pheochromocytoma	renal|hemangioma|pheochromocytoma			von_Hippel-Lindau_disease|Chuvash_Polycythemia_|Pheochromocytoma_(Adrenal)_Familial				3	28					0	0	0.009096	0	0
SLC6A11	6538	broad.mit.edu	37	3	10865066	10865066	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:10865066G>A	uc003bvz.2	+	4	646	c.612G>A	c.(610-612)ATG>ATA	p.M204I	SLC6A11_uc003bvy.1_Missense_Mutation_p.M204I	NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	204	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CCCCTGTCATGGAGTTTTGGG	0.502													16	43					0	0	0.004007	0	0
KIF15	56992	broad.mit.edu	37	3	44852400	44852400	+	Silent	SNP	T	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:44852400T>C	uc003cnx.3	+	17	2183	c.2034T>C	c.(2032-2034)CCT>CCC	p.P678P	KIF15_uc010hiq.2_Silent_p.P581P|KIF15_uc003cny.1_Silent_p.P313P	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	678	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AATTAAGCCCTGAAATGGGAA	0.373													3	41					0	0	0.004672	0	0
GPX1	2876	broad.mit.edu	37	3	49395482	49395482	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:49395482G>C	uc011bcl.1	-	2	310	c.230C>G	c.(229-231)CCG>CGG	p.P77R	GPX1_uc011bcm.1_Missense_Mutation_p.P77R	NM_000581	NP_000572	P07203	GPX1_HUMAN	glutathione peroxidase 1 isoform 1	77					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CTGGTTGCACGGGAAGCCGAG	0.617													3	28					0	0	0.009096	0	0
LRTM1	57408	broad.mit.edu	37	3	54952855	54952855	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:54952855C>T	uc003dhl.2	-	3	803	c.669G>A	c.(667-669)AGG>AGA	p.R223R	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	223	Extracellular (Potential).|LRRCT.					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		CATGAGGGATCCTAAGGAGGT	0.547													3	22					0	0	0.004672	0	0
ROBO1	6091	broad.mit.edu	37	3	78667013	78667013	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:78667013C>T	uc003dqe.2	-	27	4262	c.4054G>A	c.(4054-4056)GAG>AAG	p.E1352K	ROBO1_uc003dqb.2_Missense_Mutation_p.E1313K|ROBO1_uc003dqc.2_Missense_Mutation_p.E1252K|ROBO1_uc003dqd.2_Missense_Mutation_p.E1307K|ROBO1_uc010hoh.2_Missense_Mutation_p.E544K|ROBO1_uc011bgl.1_Missense_Mutation_p.E924K	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1352	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GGTGTCTGCTCAAGCCCACGT	0.557													7	37					0	0	0.008291	0	0
EPHA3	2042	broad.mit.edu	37	3	89176412	89176412	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:89176412C>T	uc003dqy.2	+	2	367	c.142C>T	c.(142-144)CCA>TCA	p.P48S	EPHA3_uc003dqx.1_Missense_Mutation_p.P48S|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	48	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GATCTCTTATCCATCACATGG	0.338										TSP Lung(6;0.00050)			13	53					0	0	0.004007	0	0
OR5H14	403273	broad.mit.edu	37	3	97868537	97868537	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:97868537C>T	uc003dsg.1	+	1	308	c.308C>T	c.(307-309)TCG>TTG	p.S103L		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CAGTTGTTTTCGTTTGCAATC	0.393													28	100					0	0	0.008361	0	0
OR5H6	79295	broad.mit.edu	37	3	97983179	97983179	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:97983179G>A	uc003dsi.1	+	1	51	c.51G>A	c.(49-51)ATG>ATA	p.M17I		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						GTGAGGAGATGGAAGAGGAAA	0.388													11	74					0	0	0.008291	0	0
ZBED2	79413	broad.mit.edu	37	3	111312580	111312580	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:111312580C>T	uc003dxy.2	-	2	1354	c.469G>A	c.(469-471)GAA>AAA	p.E157K	CD96_uc003dxv.2_Intron|CD96_uc003dxw.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_024508	NP_078784	Q9BTP6	ZBED2_HUMAN	zinc finger, BED domain containing 2	157							DNA binding|metal ion binding			skin(1)	1						ACCTCCTTTTCCCTTTGGCTG	0.627													18	56					0	0	0.016522	0	0
MYLK	4638	broad.mit.edu	37	3	123419849	123419849	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:123419849C>T	uc003ego.2	-	18	2748	c.2466G>A	c.(2464-2466)GGG>GGA	p.G822G	MYLK_uc011bjw.1_Silent_p.G822G|MYLK_uc003egp.2_Silent_p.G753G|MYLK_uc003egq.2_Silent_p.G822G|MYLK_uc003egr.2_Silent_p.G753G|MYLK_uc003egs.2_Silent_p.G646G|MYLK_uc003egt.2_Silent_p.G13G	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	822					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CAGGCTCCCTCCCCCTGCAAC	0.592													5	24					0	0	0.001168	0	0
MYLK	4638	broad.mit.edu	37	3	123452564	123452564	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:123452564C>T	uc003ego.2	-	10	1561	c.1279G>A	c.(1279-1281)GAA>AAA	p.E427K	MYLK_uc011bjw.1_Missense_Mutation_p.E427K|MYLK_uc003egp.2_Missense_Mutation_p.E427K|MYLK_uc003egq.2_Missense_Mutation_p.E427K|MYLK_uc003egr.2_Missense_Mutation_p.E427K|MYLK_uc003egs.2_Missense_Mutation_p.E251K	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	427	Ig-like C2-type 3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GTTTGATTTTCCTTGACCTCC	0.507													21	92					0	0	0.021523	0	0
HPS3	84343	broad.mit.edu	37	3	148858186	148858186	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:148858186G>A	uc003ewu.1	+	2	753	c.613G>A	c.(613-615)GAA>AAA	p.E205K	HPS3_uc003ewt.1_Missense_Mutation_p.E205K|HPS3_uc011bnq.1_Intron	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	205						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GTCAGACTTAGAAGTCTTAAT	0.383									Hermansky-Pudlak_syndrome				13	47					0	0	0.016723	0	0
SHOX2	6474	broad.mit.edu	37	3	157818099	157818099	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:157818099A>G	uc003fbr.2	-	3	696	c.557T>C	c.(556-558)GTT>GCT	p.V186A	SHOX2_uc003fbs.2_Missense_Mutation_p.V210A|SHOX2_uc010hvw.2_Missense_Mutation_p.V186A	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	186	Homeobox.				nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TTGAAACCAAACCTATAGGTT	0.313													5	56					0	0	0.014758	0	0
SI	6476	broad.mit.edu	37	3	164750437	164750437	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:164750437C>T	uc003fei.2	-	24	2671	c.2609G>A	c.(2608-2610)GGA>GAA	p.G870E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	870	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAAGGTAGTTCCTTCCTGATA	0.348										HNSCC(35;0.089)			6	34					0	0	0.001984	0	0
MECOM	2122	broad.mit.edu	37	3	168833264	168833264	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:168833264C>T	uc003ffi.3	-	7	2101	c.1832G>A	c.(1831-1833)GGA>GAA	p.G611E	MECOM_uc010hwk.1_Missense_Mutation_p.G634E|MECOM_uc003ffj.3_Missense_Mutation_p.G676E|MECOM_uc011bpi.1_Missense_Mutation_p.G612E|MECOM_uc003ffn.3_Missense_Mutation_p.G611E|MECOM_uc003ffk.2_Missense_Mutation_p.G611E|MECOM_uc003ffl.2_Missense_Mutation_p.G771E|MECOM_uc011bpj.1_Missense_Mutation_p.G799E|MECOM_uc011bpk.1_Missense_Mutation_p.G601E|MECOM_uc010hwn.2_Missense_Mutation_p.G799E	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	611					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TCCTTTTTTTCCCCCAAACAC	0.502													9	25					0	0	0.006214	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169664277	169664277	+	RNA	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:169664277G>A	uc011bpp.1	-	2		c.3526C>T				NR_027622				Homo sapiens cDNA FLJ41016 fis, clone UTERU2018784.												0						TGTTGCACAGGATCTTGTTGT	0.517													12	37					0	0	0.013537	0	0
RPL39L	116832	broad.mit.edu	37	3	186839028	186839028	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:186839028G>A	uc003fre.1	-	3	416	c.61C>T	c.(61-63)CGT>TGT	p.R21C	RPL39L_uc003frf.1_RNA	NM_052969	NP_443201	Q96EH5	RL39L_HUMAN	ribosomal protein L39-like protein	21					spermatogenesis|translation	cytosolic large ribosomal subunit	structural constituent of ribosome				0	all_cancers(143;2.61e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.87e-18)	GBM - Glioblastoma multiforme(93;0.0745)		GGGATGGGACGATTTTGCTTT	0.458													7	74					0	0	0.001984	0	0
ATP13A5	344905	broad.mit.edu	37	3	193081925	193081925	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:193081925C>T	uc011bsq.1	-	2	208	c.208G>A	c.(208-210)GAA>AAA	p.E70K		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	70					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		GTGTCTGCTTCTTGCAAGGGG	0.527													36	97					0	0	0.019004	0	0
ATP13A3	79572	broad.mit.edu	37	3	194162180	194162180	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:194162180G>A	uc003fty.3	-	15	1972	c.1570C>T	c.(1570-1572)CCA>TCA	p.P524S	ATP13A3_uc003ftz.1_Missense_Mutation_p.P230S	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	524					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TTTTCTTCTGGTGAAAGAAAT	0.333													6	28					0	0	0.001984	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23833376	23833376	+	Splice_Site	SNP	T	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:23833376T>A	uc003gqs.2	-	3	355	c.235_splice	c.e3-1	p.K79_splice	PPARGC1A_uc003gqt.2_Splice_Site|PPARGC1A_uc011bxp.1_Splice_Site|PPARGC1A_uc010ier.1_Splice_Site	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor						androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				ATCTATCTTCTGCAGAAAGAG	0.448													14	103					0	0	0.016723	0	0
SLC34A2	10568	broad.mit.edu	37	4	25673274	25673274	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:25673274C>T	uc003grr.2	+	9	1060	c.979C>T	c.(979-981)CTC>TTC	p.L327F	SLC34A2_uc003grs.2_Missense_Mutation_p.L326F|SLC34A2_uc010iev.2_Missense_Mutation_p.L326F	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	327	Extracellular (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				CTCCCCTTCCCTCTGTTGGAC	0.502													14	164					0	0	0.020292	0	0
RBM47	54502	broad.mit.edu	37	4	40440415	40440415	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:40440415C>T	uc003gvc.2	-	4	1206	c.496G>A	c.(496-498)GAA>AAA	p.E166K	RBM47_uc003gvd.2_Missense_Mutation_p.E166K|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.E128K|RBM47_uc003gvg.1_Missense_Mutation_p.E166K	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	166	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(3)	3						TCCAGGATTTCCTCGCGCTTC	0.637													16	45					0	0	0.004007	0	0
PDGFRA	5156	broad.mit.edu	37	4	55153703	55153703	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:55153703C>T	uc003han.3	+	19	3000	c.2669C>T	c.(2668-2670)TCC>TTC	p.S890F	PDGFRA_uc003haa.2_Missense_Mutation_p.S650F	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	890	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GAGATCTTTTCCCTTGGTATG	0.483			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			20	54					0	0	0.008871	0	0
ARL9	132946	broad.mit.edu	37	4	57384993	57384993	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:57384993C>T	uc003hby.1	+	3	614	c.166C>T	c.(166-168)CCT>TCT	p.P56S		NM_206919	NP_996802	Q6T311	ARL9_HUMAN	ADP-ribosylation factor-like 9	120							GTP binding				0	Glioma(25;0.08)|all_neural(26;0.101)					CCCAGTACTTCCTCTGGTTGT	0.378													8	26					0	0	0.003080	0	0
ANKRD17	26057	broad.mit.edu	37	4	73942768	73942768	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:73942768G>A	uc003hgp.2	-	33	7758	c.7641C>T	c.(7639-7641)ATC>ATT	p.I2547I	ANKRD17_uc003hgo.2_Silent_p.I2434I|ANKRD17_uc003hgq.2_Silent_p.I2296I|ANKRD17_uc003hgr.2_Silent_p.I2546I	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2547					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CACCATCAGGGATAGGTGCTA	0.428													17	34					0	0	0.004007	0	0
CYP2U1	113612	broad.mit.edu	37	4	108870574	108870574	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:108870574C>T	uc003hyp.2	+	4	1440	c.1357C>T	c.(1357-1359)CCA>TCA	p.P453S	CYP2U1_uc011cfi.1_Missense_Mutation_p.P244S	NM_183075	NP_898898	Q7Z449	CP2U1_HUMAN	cytochrome P450, family 2, subfamily U,	453					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000128)		ACATAGAGACCCAGCCATTTG	0.408													4	42					0	0	0.009096	0	0
SYNPO2	171024	broad.mit.edu	37	4	119948129	119948130	+	Missense_Mutation	DNP	CC	GT	GT			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:119948129_119948130CC>GT	uc003icm.3	+	3	801_802	c.605_606CC>GT	c.(604-606)TCC>TGT	p.S202C	SYNPO2_uc010ina.2_Missense_Mutation_p.S202C|SYNPO2_uc010inb.2_Missense_Mutation_p.S202C|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.S130C	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	202						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						CTGCAACTGTCCCTTTCACAGG	0.54													5	22					0	0	0.004672	0	0
SMARCA5	8467	broad.mit.edu	37	4	144466732	144466732	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:144466732A>C	uc003ijg.2	+	18	2855	c.2393A>C	c.(2392-2394)TAC>TCC	p.Y798S		NM_003601	NP_003592	O60264	SMCA5_HUMAN	SWI/SNF-related matrix-associated	798					CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)					ACTATTGGGTACAAGGTAATT	0.318													4	39					0	0	0.009096	0	0
DCHS2	54798	broad.mit.edu	37	4	155157594	155157594	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:155157594G>A	uc003inw.2	-	25	6845	c.6845C>T	c.(6844-6846)ACC>ATC	p.T2282I		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2282	Cadherin 20.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GACAGTTAAGGTGAATTTTGT	0.353													8	37					0	0	0.003080	0	0
DCHS2	54798	broad.mit.edu	37	4	155241981	155241981	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:155241981G>A	uc003inw.2	-	14	3205	c.3205C>T	c.(3205-3207)CCC>TCC	p.P1069S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1069	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GTTCCTATGGGAACATTCTCC	0.438													21	74					0	0	0.008871	0	0
GRIA2	2891	broad.mit.edu	37	4	158254097	158254097	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:158254097C>T	uc003ipm.3	+	7	1468	c.1009C>T	c.(1009-1011)CCC>TCC	p.P337S	GRIA2_uc011cit.1_Missense_Mutation_p.P290S|GRIA2_uc003ipl.3_Missense_Mutation_p.P337S|GRIA2_uc003ipk.3_Missense_Mutation_p.P290S|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	337	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CCCAGCAGTGCCCTGGGGACA	0.458													8	41					0	0	0.003080	0	0
TLL1	7092	broad.mit.edu	37	4	166986935	166986935	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:166986935C>T	uc003irh.1	+	16	2755	c.2108C>T	c.(2107-2109)TCC>TTC	p.S703F	TLL1_uc011cjn.1_Missense_Mutation_p.S726F|TLL1_uc011cjo.1_Missense_Mutation_p.S527F	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	703	CUB 3.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GTGATCACATCCCAGTTCAAC	0.398													6	67					0	0	0.001168	0	0
SORBS2	8470	broad.mit.edu	37	4	186545539	186545539	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr4:186545539G>A	uc003iyl.2	-	13	1890	c.1032C>T	c.(1030-1032)GTC>GTT	p.V344V	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Silent_p.V444V|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Silent_p.V248V|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Silent_p.V458V|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	344						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		AGTCCCGAGGGACATCCAAGT	0.507													16	52					0	0	0.003163	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5146391	5146391	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:5146391C>T	uc003jdl.2	+	3	462	c.324C>T	c.(322-324)TTC>TTT	p.F108F	ADAMTS16_uc003jdk.1_Silent_p.F108F|ADAMTS16_uc003jdj.1_Silent_p.F108F	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	108					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						GGCACGACTTCCACATGGATC	0.552													11	39					0	0	0.008291	0	0
DNAH5	1767	broad.mit.edu	37	5	13700980	13700980	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:13700980C>T	uc003jfd.2	-	78	13534	c.13492G>A	c.(13492-13494)GAA>AAA	p.E4498K	DNAH5_uc003jfc.2_Missense_Mutation_p.E666K	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4498					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CGAGTTATTTCCTATTCAGGG	0.453									Kartagener_syndrome				8	51					0	0	0.003080	0	0
DNAH5	1767	broad.mit.edu	37	5	13824439	13824439	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:13824439G>A	uc003jfd.2	-	39	6490	c.6448C>T	c.(6448-6450)CAT>TAT	p.H2150Y		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2150	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAGTCATAATGAACCTAGAGA	0.388									Kartagener_syndrome				3	23					0	0	0.004672	0	0
CDH6	1004	broad.mit.edu	37	5	31305281	31305281	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:31305281C>T	uc003jhe.1	+	7	1326	c.1000C>T	c.(1000-1002)CTC>TTC	p.L334F	CDH6_uc003jhd.1_Missense_Mutation_p.L334F	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	334	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CAACCTCAAGCTCTTGGACTT	0.423													19	52					0	0	0.008871	0	0
IL7R	3575	broad.mit.edu	37	5	35876446	35876446	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:35876446G>A	uc003jjs.2	+	8	1327	c.1238G>A	c.(1237-1239)AGC>AAC	p.S413N	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	413	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ACTACAAACAGCACGCTGCCC	0.522													14	40					0	0	0.004007	0	0
C7	730	broad.mit.edu	37	5	40947853	40947853	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:40947853C>T	uc003jmh.2	+	8	1002	c.888C>T	c.(886-888)ATC>ATT	p.I296I	C7_uc011cpn.1_Intron	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	296	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				GAAGATTAATCGACCAGTACG	0.408													15	52					0	0	0.003163	0	0
C6	729	broad.mit.edu	37	5	41155163	41155163	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:41155163G>A	uc003jmk.2	-	14	2222	c.2012C>T	c.(2011-2013)TCA>TTA	p.S671L	C6_uc003jml.1_Missense_Mutation_p.S671L	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	671	Sushi 1.|C5b-binding domain.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AGTAAGGCATGAAATTTCAAC	0.398													10	41					0	0	0.006214	0	0
MCCC2	64087	broad.mit.edu	37	5	70892176	70892176	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:70892176A>G	uc003kbs.3	+	3	404	c.266A>G	c.(265-267)AAT>AGT	p.N89S	MCCC2_uc010iyv.1_Missense_Mutation_p.N89S|MCCC2_uc003kbt.3_RNA	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	89	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	AGAATTGACAATCTCATAGAC	0.388													21	81					0	0	0.012319	0	0
SV2C	22987	broad.mit.edu	37	5	75490905	75490905	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:75490905C>T	uc003kei.1	+	3	876	c.742C>T	c.(742-744)CGC>TGC	p.R248C		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	248	Extracellular (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		TCTCTTCTGTCGCTTACTTTC	0.388													20	184					0	0	0.016522	0	0
VCAN	1462	broad.mit.edu	37	5	82815321	82815321	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:82815321G>A	uc003kii.3	+	7	1552	c.1196G>A	c.(1195-1197)GGA>GAA	p.G399E	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.G399E|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	399	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCTCCCGTGGGAAATATTGTC	0.423													7	99					0	0	0.001984	0	0
HAPLN1	1404	broad.mit.edu	37	5	82948397	82948397	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:82948397C>T	uc003kim.2	-	2	418	c.347G>A	c.(346-348)GGA>GAA	p.G116E	HAPLN1_uc003kin.2_Missense_Mutation_p.G116E	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	116	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		ATCACTGCCTCCCTTCAGAAA	0.428													7	80					0	0	0.003080	0	0
FBXL17	64839	broad.mit.edu	37	5	107197446	107197446	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:107197446G>A	uc011cvc.1	-	9	2488	c.2081C>T	c.(2080-2082)CCC>CTC	p.P694L		NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	694											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		AGACATGTTGGGGGTCCAGCC	0.582													9	33					0	0	0.008291	0	0
ACSL6	23305	broad.mit.edu	37	5	131303644	131303644	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:131303644C>T	uc010jdo.1	-	16	1593	c.1510G>A	c.(1510-1512)GGA>AGA	p.G504R	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.G529R|ACSL6_uc003kvy.1_Missense_Mutation_p.G529R|ACSL6_uc003kwb.2_Missense_Mutation_p.G494R|ACSL6_uc003kvz.1_Missense_Mutation_p.G429R|ACSL6_uc003kwa.1_Missense_Mutation_p.G515R|ACSL6_uc003kvw.1_Missense_Mutation_p.G150R|ACSL6_uc010jdn.1_Missense_Mutation_p.G519R	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	504	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCTCCCTCTCCTTTGCAGGCC	0.488													7	110					0	0	0.003080	0	0
ACSL6	23305	broad.mit.edu	37	5	131329887	131329887	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:131329887C>T	uc010jdo.1	-	2	115	c.32G>A	c.(31-33)CGA>CAA	p.R11Q	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.R36Q|ACSL6_uc003kvy.1_Missense_Mutation_p.R36Q|ACSL6_uc003kwb.2_Missense_Mutation_p.R36Q|ACSL6_uc003kvz.1_Missense_Mutation_p.R11Q|ACSL6_uc003kwa.1_Missense_Mutation_p.R22Q|ACSL6_uc003kwc.1_Missense_Mutation_p.R11Q|ACSL6_uc003kwd.1_Missense_Mutation_p.R11Q|ACSL6_uc010jdn.1_Missense_Mutation_p.R11Q	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	11					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTCAGGCAGTCGCAGTATCCT	0.547													5	22					0	0	0.014758	0	0
BRD8	10902	broad.mit.edu	37	5	137502286	137502286	+	Silent	SNP	T	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:137502286T>C	uc003lcf.1	-	10	973	c.918A>G	c.(916-918)CAA>CAG	p.Q306Q	BRD8_uc003lcc.1_Intron|BRD8_uc011cyl.1_Silent_p.Q85Q|BRD8_uc003lcg.2_Silent_p.Q379Q|BRD8_uc003lci.2_Intron|BRD8_uc003lch.2_Silent_p.Q200Q|BRD8_uc011cym.1_Silent_p.Q290Q|BRD8_uc010jer.1_Intron|BRD8_uc011cyn.1_Silent_p.Q265Q	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	306				Q -> H (in Ref. 6; AAB87858).	cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAATGGTAGCTTGGGACACAG	0.557													7	28					0	0	0.004482	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515911	140515911	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:140515911G>A	uc003liq.2	+	1	1112	c.895G>A	c.(895-897)GAA>AAA	p.E299K		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	299	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAAACAGCAGAAATTCGCCT	0.448													20	74					0	0	0.010504	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531943	140531943	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:140531943C>T	uc003lir.2	+	1	2105	c.2105C>T	c.(2104-2106)TCG>TTG	p.S702L	PCDHB6_uc011dah.1_Missense_Mutation_p.S566L	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	702	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCCTCTTTTCGGTGCTCCTG	0.687													31	116					0	0	0.017118	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731426	140731426	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:140731426G>A	uc003ljo.1	+	1	1599	c.1599G>A	c.(1597-1599)CAG>CAA	p.Q533Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Silent_p.Q533Q	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	533	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGGGACCAGGGCTCCCCCG	0.701													15	55					0	0	0.020292	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140794192	140794192	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:140794192G>A	uc003lkl.1	+	1	1450	c.1450G>A	c.(1450-1452)GAC>AAC	p.D484N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.D484N	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	484	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGACCCGGACAGCAAAGA	0.517													8	111					0	0	0.004482	0	0
PDGFRB	5159	broad.mit.edu	37	5	149495355	149495355	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:149495355G>A	uc003lro.2	-	23	3761	c.3292C>T	c.(3292-3294)CGG>TGG	p.R1098W	CSF1R_uc003lrm.2_5'Flank|PDGFRB_uc003lrn.1_5'Flank|PDGFRB_uc010jhd.2_Missense_Mutation_p.R937W	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	1098	Cytoplasmic (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GCTTCCGCCCGAGGCGCAGGG	0.687			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								10	30					0	0	0.020292	0	0
GRIA1	2890	broad.mit.edu	37	5	153190641	153190642	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:153190641_153190642CC>TT	uc003lva.3	+	16	2942_2943	c.2577_2578CC>TT	c.(2575-2580)CTCCCC>CTTTCC	p.P860S	GRIA1_uc003luy.3_Missense_Mutation_p.P860S|GRIA1_uc003luz.3_Missense_Mutation_p.P765S|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.P780S|GRIA1_uc011dcx.1_Missense_Mutation_p.P791S|GRIA1_uc011dcy.1_Missense_Mutation_p.P870S|GRIA1_uc011dcz.1_Missense_Mutation_p.P870S	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	860	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CATCGACCCTCCCCCGCAACAG	0.584													8	53					0	0	0.004672	0	0
GABRB2	2561	broad.mit.edu	37	5	160758016	160758016	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr5:160758016G>A	uc003lys.1	-	9	1169	c.951C>T	c.(949-951)TTC>TTT	p.F317F	GABRB2_uc011deh.1_Silent_p.F156F|GABRB2_uc003lyr.1_Silent_p.F317F|GABRB2_uc003lyt.1_Silent_p.F317F|GABRB2_uc010jiu.1_Silent_p.F254F	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	317	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GAAGGGCCATGAAAACGAAGA	0.507													9	89					0	0	0.008291	0	0
DUSP22	56940	broad.mit.edu	37	6	348139	348139	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:348139C>T	uc003msx.2	+	6	739	c.300C>T	c.(298-300)ATC>ATT	p.I100I	DUSP22_uc011dhn.1_Silent_p.I100I|DUSP22_uc003msy.1_Silent_p.I57I	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	100	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CACTGGTGATCGCATACATCA	0.607													21	152					0	0	0.010504	0	0
JARID2	3720	broad.mit.edu	37	6	15513580	15513580	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:15513580C>T	uc003nbj.2	+	16	3621	c.3377C>T	c.(3376-3378)CCT>CTT	p.P1126L	JARID2_uc011div.1_Missense_Mutation_p.P954L	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	1126					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AAGAAAAAGCCTCGAAAGTGG	0.657													12	33					0	0	0.016723	0	0
ATXN1	6310	broad.mit.edu	37	6	16327065	16327065	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:16327065G>A	uc003nbt.2	-	8	2448	c.1477C>T	c.(1477-1479)CCG>TCG	p.P493S	ATXN1_uc010jpi.2_Missense_Mutation_p.P493S|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	493					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CTGCCGACCGGGATGAGCAGG	0.667													26	148					0	0	0.006320	0	0
MOG	4340	broad.mit.edu	37	6	29625034	29625034	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:29625034C>T	uc003nnf.2	+	1	226	c.48C>T	c.(46-48)TTC>TTT	p.F16F	MOG_uc003qzk.1_Silent_p.F16F|MOG_uc010kle.1_RNA|MOG_uc010klf.1_RNA|MOG_uc003nmy.1_Silent_p.F16F|MOG_uc003nmz.2_Silent_p.F16F|MOG_uc011dlt.1_5'UTR|MOG_uc003nna.2_Silent_p.F16F|MOG_uc011dlu.1_Silent_p.F16F|MOG_uc011dlv.1_Silent_p.F16F|MOG_uc003nnd.2_Silent_p.F16F|MOG_uc003nne.2_Silent_p.F16F|MOG_uc003nng.2_Silent_p.F16F|MOG_uc003nnh.2_Silent_p.F16F|MOG_uc003nni.2_Silent_p.F16F|MOG_uc003nnj.2_Silent_p.F16F|MOG_uc003nnk.2_Silent_p.F16F	NM_206809	NP_996532	Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein isoform	16					cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)	1						TCTGCTCCTtcctcctcctcc	0.478													4	22					0	0	0.009096	0	0
HLA-F	3134	broad.mit.edu	37	6	29692182	29692182	+	Silent	SNP	C	T	T	rs138293991	by1000genomes	TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:29692182C>T	uc010jrl.2	+	3	691	c.567C>T	c.(565-567)CTC>CTT	p.L189L	HLA-F_uc003nnm.3_Silent_p.L189L|HLA-F_uc003nno.3_Silent_p.L189L|HLA-F_uc011dlx.1_Silent_p.L189L|HLA-F_uc011dly.1_RNA	NM_018950	NP_061823	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	189	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						TGGAGTTGCTCCGCAGATACT	0.602													8	52					0	0	0.004482	0	0
HLA-E	3133	broad.mit.edu	37	6	30459126	30459126	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:30459126G>A	uc003nqg.2	+	4	861	c.823G>A	c.(823-825)GAG>AAG	p.E275K	HLA-E_uc011dmg.1_RNA|HLA-E_uc011dmh.1_Missense_Mutation_p.E316K	NM_005516	NP_005507	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	275	Ig-like C1-type.|Alpha-3.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(4)|ovary(1)	5						TTCTGGAGAGGAGCAGAGATA	0.617													11	62					0	0	0.008291	0	0
BAT2	7916	broad.mit.edu	37	6	31596995	31596995	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:31596995C>T	uc003nvb.3	+	13	2089	c.1840C>T	c.(1840-1842)CCA>TCA	p.P614S	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.P614S	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	614	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						ACCCCCAGTTCCAAAGGTGGA	0.552													26	98					0	0	0.005443	0	0
TNXB	7148	broad.mit.edu	37	6	32037589	32037589	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:32037589G>A	uc003nzl.2	-	15	5530	c.5328C>T	c.(5326-5328)CCC>CCT	p.P1776P		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1858	Fibronectin type-III 11.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCCCCAGACGGGGTTTTGGGG	0.587													67	302					0	0	0.014410	0	0
NOTCH4	4855	broad.mit.edu	37	6	32183118	32183118	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:32183118G>T	uc003obb.2	-	12	2045	c.1906C>A	c.(1906-1908)CCC>ACC	p.P636T	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	636	EGF-like 16.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						ATCTGCTTGGGCTGGCACAGG	0.572													42	230					1.61863e-15	1.70761e-15	0.014410	1	0
RNF8	9025	broad.mit.edu	37	6	37336896	37336896	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:37336896C>T	uc003onq.3	+	3	1070	c.877C>T	c.(877-879)CAG>TAG	p.Q293*	RNF8_uc003onr.3_Nonsense_Mutation_p.Q293*|RNF8_uc011dtx.1_Nonsense_Mutation_p.Q225*	NM_003958	NP_003949	O76064	RNF8_HUMAN	ring finger protein 8 isoform 1	293	Gln-rich.				cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						GCAGGAACTTCAGGACTTACA	0.468													9	38					0	0	0.006214	0	0
MDGA1	266727	broad.mit.edu	37	6	37622290	37622290	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:37622290C>T	uc003onu.1	-	6	1921	c.742G>A	c.(742-744)GAA>AAA	p.E248K	MDGA1_uc003onw.3_5'Flank	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	248	Ig-like 3.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						ACCAGAGTTTCGTTCACAGAC	0.617													25	94					0	0	0.005443	0	0
DNAH8	1769	broad.mit.edu	37	6	38891880	38891880	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:38891880G>A	uc003ooe.1	+	71	10853	c.10253G>A	c.(10252-10254)CGG>CAG	p.R3418Q	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTGAGAGCACGGAAAATTCCT	0.373													14	60					0	0	0.016723	0	0
CRISP1	167	broad.mit.edu	37	6	49815925	49815925	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:49815925G>A	uc003ozw.2	-	4	362	c.283C>T	c.(283-285)CCA>TCA	p.P95S	CRISP1_uc003ozx.2_Missense_Mutation_p.P95S	NM_001131	NP_001122	P54107	CRIS1_HUMAN	acidic epididymal glycoprotein-like 1 isoform 1	95					fusion of sperm to egg plasma membrane	extracellular space					0	Lung NSC(77;0.0358)					CACTTACTTGGAAGTCTCCTC	0.373													15	73					0	0	0.003163	0	0
FAM83B	222584	broad.mit.edu	37	6	54805208	54805208	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:54805208G>A	uc003pck.2	+	5	1555	c.1439G>A	c.(1438-1440)CGA>CAA	p.R480Q		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	480										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TTGCAACAACGAATGCCAACC	0.413													16	44					0	0	0.010504	0	0
LGSN	51557	broad.mit.edu	37	6	63990239	63990239	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:63990239T>G	uc003peh.2	-	4	1251	c.1217A>C	c.(1216-1218)GAA>GCA	p.E406A	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	406					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	TAGTTTATTTTCTATCCGGGT	0.448													22	70					0	0	0.012319	0	0
IMPG1	3617	broad.mit.edu	37	6	76728558	76728558	+	Silent	SNP	G	A	A	rs142510377	by1000genomes	TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:76728558G>A	uc003pik.1	-	7	814	c.684C>T	c.(682-684)TTC>TTT	p.F228F		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	228					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CCAACACAGCGAATTCTGTTT	0.413													13	24					0	0	0.016723	0	0
LAMA4	3910	broad.mit.edu	37	6	112440433	112440433	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:112440433C>T	uc003pvu.2	-	34	5056	c.4747G>A	c.(4747-4749)GAA>AAA	p.E1583K	LAMA4_uc003pvv.2_Missense_Mutation_p.E1576K|LAMA4_uc003pvt.2_Missense_Mutation_p.E1576K	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1583	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CAGGTAGCTTCAGTAGGAGGA	0.463													18	63					0	0	0.008871	0	0
MAN1A1	4121	broad.mit.edu	37	6	119525949	119525949	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:119525949G>A	uc003pym.1	-	7	1533	c.1091C>T	c.(1090-1092)TCA>TTA	p.S364L		NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	364	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		GGGGTTTCCTGATAAGTGGCT	0.468													12	59					0	0	0.010729	0	0
SYNJ2	8871	broad.mit.edu	37	6	158509711	158509711	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:158509711G>A	uc003qqx.1	+	24	3438	c.3363G>A	c.(3361-3363)AAG>AAA	p.K1121K	SYNJ2_uc003qqw.1_Silent_p.K1121K|SYNJ2_uc003qqy.1_Silent_p.K834K|SYNJ2_uc003qqz.1_Silent_p.K738K|SYNJ2_uc003qra.1_Silent_p.K464K|SYNJ2_uc010kjp.1_Silent_p.K4K	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1121	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		TGGTGAAAAAGTCGGCTTCAG	0.527													29	67					0	0	0.007291	0	0
LPA	4018	broad.mit.edu	37	6	161007619	161007619	+	Missense_Mutation	SNP	G	A	A	rs147936725	by1000genomes	TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:161007619G>A	uc003qtl.2	-	26	4111	c.3991C>T	c.(3991-3993)CGC>TGC	p.R1331C		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3839	Kringle 34.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CACCAAGGGCGAATCTCAGCA	0.498													17	30					0	0	0.004990	0	0
TCP10L2	401285	broad.mit.edu	37	6	167585680	167585680	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr6:167585680C>T	uc010kkp.2	+	2	179	c.48C>T	c.(46-48)CAC>CAT	p.H16H		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	16											0						AGGGCACCCACCCAGAGGACC	0.667													5	9					0	0	0.014758	0	0
RAC1	5879	broad.mit.edu	37	7	6441629	6441629	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:6441629C>T	uc003spx.2	+	5	660	c.419C>T	c.(418-420)CCG>CTG	p.P140L	RAC1_uc003spw.2_Missense_Mutation_p.P159L	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	140					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	ATCACCTATCCGCAGGGTCTA	0.458													18	93					0	0	0.014323	0	0
PMS2CL	441194	broad.mit.edu	37	7	6777288	6777288	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:6777288A>C	uc011jxb.1	+	5	1342	c.568A>C	c.(568-570)ACA>CCA	p.T190P	PMS2CL_uc003squ.2_RNA|PMS2CL_uc003sqv.1_RNA					SubName: Full=cDNA FLJ60281, highly similar to PMS1 protein homolog 2;												0						ATCCCCAAACACAAAAGTGTT	0.393													8	49					0	0	0.003080	0	0
DNAH11	8701	broad.mit.edu	37	7	21826306	21826306	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:21826306C>T	uc003svc.2	+	60	9714	c.9683C>T	c.(9682-9684)GCC>GTC	p.A3228V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3228	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTTACTGCAGCCGTGATGGTC	0.522									Kartagener_syndrome				13	87					0	0	0.020292	0	0
IL6	3569	broad.mit.edu	37	7	22769227	22769227	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:22769227C>G	uc011jyn.1	+	5	878	c.419C>G	c.(418-420)GCC>GGC	p.A140G	uc010kun.1_5'Flank|IL6_uc011jyo.1_Missense_Mutation_p.A140G|IL6_uc011jyp.1_Missense_Mutation_p.A64G|IL6_uc003svj.3_Missense_Mutation_p.A140G|IL6_uc011jyq.1_Missense_Mutation_p.A194G	NM_000600	NP_000591	P05231	IL6_HUMAN	interleukin 6 precursor	140					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding				0					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	GAGGAACAAGCCAGAGCTGTG	0.478													13	50					0	0	0.020292	0	0
AEBP1	165	broad.mit.edu	37	7	44151192	44151192	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:44151192C>T	uc003tkb.2	+	15	2108	c.1803C>T	c.(1801-1803)GCC>GCT	p.A601A	AEBP1_uc003tkc.3_Silent_p.A176A|AEBP1_uc003tkd.2_5'UTR	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	601	Interaction with MAPK1 and MAPK3 (By similarity).|Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGATCTATGCCATGGAGATCT	0.617													5	37					0	0	0.001168	0	0
PKD1L1	168507	broad.mit.edu	37	7	47874752	47874752	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:47874752G>A	uc003tny.1	-	38	6033	c.6033C>T	c.(6031-6033)TCC>TCT	p.S2011S		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2011	Helical; (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TGAAGAGCAGGGACAAGAGCT	0.607													7	41					0	0	0.003080	0	0
PKD1L1	168507	broad.mit.edu	37	7	47913507	47913507	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:47913507C>T	uc003tny.1	-	24	3886	c.3886G>A	c.(3886-3888)GGC>AGC	p.G1296S		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1296	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						AGGTCCTCGCCCAGACAGTCA	0.507													8	36					0	0	0.003080	0	0
ABCA13	154664	broad.mit.edu	37	7	48427419	48427419	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:48427419G>A	uc003toq.2	+	36	11361	c.11336G>A	c.(11335-11337)GGA>GAA	p.G3779E	ABCA13_uc010kys.1_Missense_Mutation_p.G853E|ABCA13_uc003tos.1_Missense_Mutation_p.G605E|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3779					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CATTTTTTAGGAACATTTGGT	0.294													3	8					0	0	0.004672	0	0
ZNF716	441234	broad.mit.edu	37	7	57522875	57522875	+	Splice_Site	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:57522875G>A	uc011kdi.1	+	3	374	c.262_splice	c.e3+1	p.V88_splice		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						AAACACCCAGGTAGGTGAGAG	0.458													15	66					0	0	0.003163	0	0
ZNF735	730291	broad.mit.edu	37	7	63673514	63673514	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:63673514G>A	uc011kdn.1	+	2	84	c.84G>A	c.(82-84)GCG>GCA	p.A28A		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCTCTCTGGCGGAGTGGCAAT	0.413													6	16					0	0	0.001168	0	0
TYW1B	441250	broad.mit.edu	37	7	72193812	72193812	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:72193812C>G	uc011kej.1	-	12	1329	c.1170G>C	c.(1168-1170)CAG>CAC	p.Q390H	TYW1B_uc011keh.1_Missense_Mutation_p.Q228H|TYW1B_uc011kei.1_Missense_Mutation_p.Q16H|TYW1B_uc011kek.1_RNA	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	390					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						TAATCATGTTCTGATGGTTTT	0.418													6	33					0	0	0.003080	0	0
SEMA3E	9723	broad.mit.edu	37	7	82997096	82997096	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:82997096C>T	uc003uhy.1	-	17	2600	c.2134G>A	c.(2134-2136)GAA>AAA	p.E712K		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	712					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TGCAAGAATTCCTTGTACCAT	0.458													19	82					0	0	0.007413	0	0
ZAN	7455	broad.mit.edu	37	7	100334225	100334225	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:100334225G>C	uc003uwj.2	+	4	391	c.226G>C	c.(226-228)GGG>CGG	p.G76R	ZAN_uc003uwk.2_Missense_Mutation_p.G76R|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	76	MAM 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CGGCTCCACCGGGGCCCCCGG	0.642													14	21					0	0	0.003163	0	0
CUX1	1523	broad.mit.edu	37	7	101847737	101847737	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:101847737A>T	uc003uyx.3	+	19	3012	c.2974A>T	c.(2974-2976)ACG>TCG	p.T992S	CUX1_uc003uys.3_Missense_Mutation_p.T1003S|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	992	CUT 2.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GAGCAAGCTGACGCAGAAAGG	0.647													22	79					0	0	0.014323	0	0
DLD	1738	broad.mit.edu	37	7	107558469	107558469	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:107558469C>T	uc003vet.2	+	12	1447	c.1337C>T	c.(1336-1338)TCG>TTG	p.S446L	DLD_uc011kmg.1_Missense_Mutation_p.S398L|DLD_uc011kmh.1_Missense_Mutation_p.S423L|DLD_uc011kmi.1_Missense_Mutation_p.S347L	NM_000108	NP_000099	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase precursor	446					branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			central_nervous_system(1)	1					NADH(DB00157)	GGGCAGAAATCGACAGACAGA	0.408													11	51					0	0	0.008291	0	0
LAMB4	22798	broad.mit.edu	37	7	107708494	107708494	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:107708494C>T	uc010ljo.1	-	19	2497	c.2413G>A	c.(2413-2415)GGA>AGA	p.G805R	LAMB4_uc003vey.2_Missense_Mutation_p.G805R	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	805	Laminin EGF-like 6.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TCATAGCTTCCAGTTGAGCAC	0.552													46	183					0	0	0.014410	0	0
DOCK4	9732	broad.mit.edu	37	7	111409609	111409609	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:111409609G>A	uc003vfx.2	-	36	4046	c.3777C>T	c.(3775-3777)ATC>ATT	p.I1259I	DOCK4_uc011kml.1_Silent_p.I140I|DOCK4_uc011kmm.1_Silent_p.I166I|DOCK4_uc003vfw.2_Silent_p.I709I|DOCK4_uc003vfy.2_Silent_p.I1304I	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1259	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				AGTTCTGGATGATGGTGAGGT	0.552													16	61					0	0	0.006122	0	0
FEZF1	389549	broad.mit.edu	37	7	121943282	121943282	+	Silent	SNP	T	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:121943282T>C	uc003vkd.2	-	2	959	c.885A>G	c.(883-885)AAA>AAG	p.K295K	FEZF1_uc003vkc.2_Silent_p.K245K|uc010lko.1_5'Flank|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	295	C2H2-type 2.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						GCCTGAAACCTTTTCCGCACA	0.468													4	114					0	0	0.009096	0	0
FLNC	2318	broad.mit.edu	37	7	128480100	128480100	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:128480100G>C	uc003vnz.3	+	9	1644	c.1435G>C	c.(1435-1437)GCC>CCC	p.A479P	FLNC_uc003voa.3_Missense_Mutation_p.A479P	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	479	Filamin 3.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CGCCTGCCGCGCCTCTGGGCG	0.642													28	116					0	0	0.013726	0	0
AKR1B10	57016	broad.mit.edu	37	7	134215553	134215553	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:134215553C>T	uc003vrr.2	+	2	545	c.225C>T	c.(223-225)ATC>ATT	p.I75I		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	75					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						ACCTGTTCATCGTCAGCAAGG	0.512													10	55					0	0	0.010729	0	0
KIAA1549	57670	broad.mit.edu	37	7	138555961	138555961	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:138555961G>A	uc011kql.1	-	13	4542	c.4493C>T	c.(4492-4494)CCC>CTC	p.P1498L	KIAA1549_uc011kqi.1_Missense_Mutation_p.P282L|KIAA1549_uc003vuk.3_Missense_Mutation_p.P1448L|KIAA1549_uc011kqj.1_Missense_Mutation_p.P1498L|KIAA1549_uc011kqk.1_Missense_Mutation_p.P282L	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1498						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GCGCTGGACGGGAGGTGCCGG	0.547			O	BRAF	pilocytic astrocytoma								15	43					0	0	0.004990	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174235	150174235	+	Silent	SNP	G	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:150174235G>T	uc003whj.2	+	5	1695	c.1365G>T	c.(1363-1365)GGG>GGT	p.G455G		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	455						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GTGCGACCGGGAACTCTATCC	0.592													11	66					2.80697e-09	2.95355e-09	0.010729	1	0
GIMAP7	168537	broad.mit.edu	37	7	150217899	150217899	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:150217899G>A	uc003whk.2	+	2	967	c.837G>A	c.(835-837)AGG>AGA	p.R279R		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	279							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTTTTAATAGGATTTGGAAGA	0.224													6	20					0	0	0.003080	0	0
MLL3	58508	broad.mit.edu	37	7	151945102	151945102	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:151945102G>A	uc003wla.2	-	14	2636	c.2417C>T	c.(2416-2418)TCC>TTC	p.S806F		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	806					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding	p.S806S(1)		large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCCAGCAGAGGAACTAAGAGC	0.438			N		medulloblastoma								18	578					0	0	0.014323	0	0
CSMD1	64478	broad.mit.edu	37	8	3076863	3076863	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:3076863C>T	uc011kwk.1	-	29	4979	c.4589G>A	c.(4588-4590)AGA>AAA	p.R1530K	CSMD1_uc011kwj.1_Missense_Mutation_p.R922K|CSMD1_uc003wqe.2_Missense_Mutation_p.R686K	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1530	Extracellular (Potential).|CUB 9.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACTCTCTATTCTTTCTGGGGC	0.507													3	4					0	0	0.004672	0	0
USP17L2	377630	broad.mit.edu	37	8	11995072	11995072	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:11995072C>T	uc003wvc.1	-	1	1198	c.1198G>A	c.(1198-1200)GAC>AAC	p.D400N	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	400					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						GCTCGCCTGTCTGTGTCTTCA	0.567													3	13					0	0	0.004672	0	0
MTMR7	9108	broad.mit.edu	37	8	17198974	17198974	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:17198974G>A	uc003wxm.2	-	6	869	c.630C>T	c.(628-630)TCC>TCT	p.S210S	MTMR7_uc003wxn.2_5'UTR	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	210	Myotubularin phosphatase.						protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		CACTGAAGCCGGACAGGGGCT	0.577													12	38					0	0	0.013537	0	0
POTEA	340441	broad.mit.edu	37	8	43159852	43159852	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:43159852T>A	uc003xpz.1	+	6	887	c.844T>A	c.(844-846)TTA>ATA	p.L282I	POTEA_uc003xqa.1_Missense_Mutation_p.L236I	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	282										ovary(1)	1						AATTTGCCAATTACTTTCTGA	0.249													8	20					0	0	0.003080	0	0
PENK	5179	broad.mit.edu	37	8	57354406	57354406	+	Missense_Mutation	SNP	G	A	A	rs148519224		TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:57354406G>A	uc003xsz.2	-	2	310	c.229C>T	c.(229-231)CCT>TCT	p.P77S	PENK_uc003xta.3_Missense_Mutation_p.P77S	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	77					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity	p.P77S(1)		ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CCATCTTGAGGAAGCTCTGGT	0.483													14	87					0	0	0.004990	0	0
CLVS1	157807	broad.mit.edu	37	8	62212827	62212827	+	Silent	SNP	T	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:62212827T>C	uc003xuh.2	+	2	765	c.441T>C	c.(439-441)AAT>AAC	p.N147N	CLVS1_uc003xug.2_Silent_p.N147N|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Silent_p.N147N	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	147	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						TTGCAGCCAATTGGGATCAGA	0.438													3	22					0	0	0.004672	0	0
NKAIN3	286183	broad.mit.edu	37	8	63659649	63659649	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:63659649C>T	uc010lyq.1	+	4	564	c.432C>T	c.(430-432)TAC>TAT	p.Y144Y		NM_173688	NP_775959	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	144						integral to membrane|plasma membrane					0	Breast(64;0.127)	Lung NSC(129;0.187)				ACTTCCAGTACCTGGAGGTCA	0.478													5	33					0	0	0.001168	0	0
SULF1	23213	broad.mit.edu	37	8	70539458	70539458	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:70539458C>T	uc010lza.1	+	16	2581	c.1864C>T	c.(1864-1866)CCC>TCC	p.P622S	SULF1_uc003xyd.2_Missense_Mutation_p.P622S|SULF1_uc003xye.2_Missense_Mutation_p.P622S|SULF1_uc003xyf.2_Missense_Mutation_p.P622S|SULF1_uc003xyg.2_Missense_Mutation_p.P622S|SULF1_uc003xyh.1_RNA|SULF1_uc003xyi.1_5'Flank	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	622					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTTTATTCTTCCCAATGACTC	0.378													4	17					0	0	0.014758	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764324	77764324	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:77764324C>T	uc003yav.2	+	10	5419	c.5032C>T	c.(5032-5034)CCT>TCT	p.P1678S	ZFHX4_uc003yau.1_Missense_Mutation_p.P1723S|ZFHX4_uc003yaw.1_Missense_Mutation_p.P1678S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1678	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCTCATTTTCCTATGACCCC	0.473										HNSCC(33;0.089)			4	52					0	0	0.009096	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767066	77767066	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:77767066C>T	uc003yav.2	+	10	8161	c.7774C>T	c.(7774-7776)CAT>TAT	p.H2592Y	ZFHX4_uc003yau.1_Missense_Mutation_p.H2637Y|ZFHX4_uc003yaw.1_Missense_Mutation_p.H2592Y	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2592	Homeobox 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AATGCTTGATCATATTGCCCG	0.512										HNSCC(33;0.089)			7	30					0	0	0.001984	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767767	77767767	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:77767767C>T	uc003yav.2	+	10	8862	c.8475C>T	c.(8473-8475)AGC>AGT	p.S2825S	ZFHX4_uc003yau.1_Silent_p.S2870S|ZFHX4_uc003yaw.1_Silent_p.S2825S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2825						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTCTCACAAGCCCATCCATCC	0.498										HNSCC(33;0.089)			5	23					0	0	0.014758	0	0
GRHL2	79977	broad.mit.edu	37	8	102589725	102589725	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:102589725G>A	uc010mbu.2	+	7	1311	c.981G>A	c.(979-981)GCG>GCA	p.A327A		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	327						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			AGCATACGGCGAAGCAGAGGG	0.498													11	45					0	0	0.010729	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110412386	110412386	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:110412386C>T	uc003yne.2	+	13	1198	c.1094C>T	c.(1093-1095)ACG>ATG	p.T365M		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	365	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AATGAAAAAACGCCTGGGTAC	0.433										HNSCC(38;0.096)			25	148					0	0	0.018920	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110477438	110477438	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:110477438G>A	uc003yne.2	+	49	8481	c.8377G>A	c.(8377-8379)GAA>AAA	p.E2793K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2793	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTGGGAACATGAAATGGTAAT	0.373										HNSCC(38;0.096)			5	30					0	0	0.003080	0	0
GSDMC	56169	broad.mit.edu	37	8	130765061	130765061	+	Missense_Mutation	SNP	C	T	T	rs142034966		TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr8:130765061C>T	uc003ysr.2	-	7	1609	c.727G>A	c.(727-729)GAA>AAA	p.E243K		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	243						mitochondrion				ovary(2)|skin(1)	3						tcggaaatttcgtactcttgg	0													7	71					0	0	0.001984	0	0
GNA14	9630	broad.mit.edu	37	9	80144101	80144101	+	Missense_Mutation	SNP	C	T	T	rs148544176		TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr9:80144101C>T	uc004aku.2	-	2	716	c.193G>A	c.(193-195)GAC>AAC	p.D65N		NM_004297	NP_004288	O95837	GNA14_HUMAN	G alpha 14	65					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(2)	2						CTGTCTTCGTCGCTGTAACCA	0.448													25	206					0	0	0.007291	0	0
SLC28A3	64078	broad.mit.edu	37	9	86920249	86920249	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr9:86920249C>T	uc010mpz.2	-	4	379	c.254G>A	c.(253-255)AGG>AAG	p.R85K	SLC28A3_uc011lsy.1_Missense_Mutation_p.R16K|SLC28A3_uc004anu.1_Missense_Mutation_p.R85K|SLC28A3_uc010mqb.2_Missense_Mutation_p.R16K	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	85	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						GTCATACCTCCTTTCCAAACA	0.383													5	33					0	0	0.001984	0	0
OR13C2	392376	broad.mit.edu	37	9	107367138	107367138	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr9:107367138G>A	uc011lvq.1	-	1	771	c.771C>T	c.(769-771)TTC>TTT	p.F257F		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCATGTACATGAAGAGGATGG	0.438													6	49					0	0	0.001984	0	0
PTPN3	5774	broad.mit.edu	37	9	112172648	112172648	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr9:112172648G>A	uc004bed.2	-	15	1473	c.1361C>T	c.(1360-1362)TCA>TTA	p.S454L	PTPN3_uc004beb.2_Missense_Mutation_p.S323L|PTPN3_uc004bec.2_Missense_Mutation_p.S278L|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.S409L|PTPN3_uc011lwh.1_Missense_Mutation_p.S300L|PTPN3_uc011lwd.1_5'UTR|PTPN3_uc011lwe.1_Missense_Mutation_p.S167L|PTPN3_uc011lwf.1_Missense_Mutation_p.S122L	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	454					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						AGAACTGGATGACTTCTGGGT	0.468													6	55					0	0	0.001168	0	0
LPAR1	1902	broad.mit.edu	37	9	113704021	113704021	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr9:113704021C>T	uc004bfa.2	-	4	728	c.473G>A	c.(472-474)CGG>CAG	p.R158Q	LPAR1_uc011lwm.1_Missense_Mutation_p.R159Q|LPAR1_uc004bfb.2_Missense_Mutation_p.R158Q|LPAR1_uc004bfc.2_Missense_Mutation_p.R158Q|LPAR1_uc011lwn.1_Missense_Mutation_p.R140Q|LPAR1_uc011lwo.1_Missense_Mutation_p.R159Q|LPAR1_uc010mub.2_Missense_Mutation_p.R158Q	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	158	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						GTTGCTCATCCGTGTGTGGAG	0.542													7	45					0	0	0.001984	0	0
ORM1	5004	broad.mit.edu	37	9	117086343	117086343	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr9:117086343G>A	uc004bik.3	+	3	414	c.303G>A	c.(301-303)CGG>CGA	p.R101R	ORM1_uc011lxo.1_Silent_p.R101R	NM_000607	NP_000598	P02763	A1AG1_HUMAN	orosomucoid 1 precursor	101					acute-phase response|regulation of immune system process|transport	extracellular space	protein binding				0		Myeloproliferative disorder(63;0.163)			Acenocoumarol(DB01418)|Alfentanil(DB00802)|Aprindine(DB01429)|Disopyramide(DB00280)|Penbutolol(DB01359)|Phenprocoumon(DB00946)|Quinidine(DB00908)|Tamsulosin(DB00706)	ATGTCCAGCGGGAAAATGGGA	0.537													10	54					0	0	0.006214	0	0
TTC16	158248	broad.mit.edu	37	9	130492962	130492962	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr9:130492962G>A	uc004brq.1	+	14	1967	c.1900G>A	c.(1900-1902)GAA>AAA	p.E634K	TTC16_uc011mai.1_Missense_Mutation_p.E621K|TTC16_uc004brr.1_Silent_p.R454R|TTC16_uc010mxn.1_Missense_Mutation_p.E230K	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	634							binding				0						TATCTGCCAGGAATACAGGAG	0.587													4	28					0	0	0.009096	0	0
TMEM8C	389827	broad.mit.edu	37	9	136385350	136385350	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr9:136385350G>A	uc011mdk.1	-	2	196	c.196C>T	c.(196-198)CTG>TTG	p.L66L		NM_001080483	NP_001073952	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	66	Helical; (Potential).					integral to membrane					0						AAATACTCCAGGATGTCGTGA	0.587													3	27					0	0	0.004672	0	0
ARSF	416	broad.mit.edu	37	X	3030371	3030371	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:3030371C>T	uc004cre.1	+	11	1768	c.1547C>T	c.(1546-1548)TCC>TTC	p.S516F	ARSF_uc004crf.1_Missense_Mutation_p.S516F	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	516						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCCTCAGAGTCCACACCCCTG	0.547													9	75					0	0	0.006214	0	0
REPS2	9185	broad.mit.edu	37	X	17040294	17040294	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:17040294G>A	uc004cxv.1	+	3	617	c.446G>A	c.(445-447)CGA>CAA	p.R149Q	REPS2_uc004cxw.1_Missense_Mutation_p.R149Q|REPS2_uc011miw.1_Missense_Mutation_p.R9Q	NM_004726	NP_004717	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	149					epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					GGTGAGATACGATTTGGGAAC	0.393													18	95					0	0	0.007413	0	0
PCYT1B	9468	broad.mit.edu	37	X	24625972	24625972	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:24625972C>T	uc004dbi.2	-	3	457	c.224G>A	c.(223-225)AGG>AAG	p.R75K	PCYT1B_uc004dbk.3_Missense_Mutation_p.R75K|PCYT1B_uc004dbj.2_Missense_Mutation_p.R57K	NM_004845	NP_004836	Q9Y5K3	PCY1B_HUMAN	choline phosphate cytidylyltransferase 1 beta	75	Catalytic (Potential).					endoplasmic reticulum	choline-phosphate cytidylyltransferase activity				0					Choline(DB00122)	TCTGACAGGCCTGTCAGCTGT	0.443													3	11					0	0	0.014758	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254885	30254885	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:30254885G>A	uc004dca.1	+	5	1581	c.844G>A	c.(844-846)GAA>AAA	p.E282K		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	282	MAGE.										0						AGCCCATGCTGAAACCAGCAA	0.493													5	51					0	0	0.001168	0	0
KDM6A	7403	broad.mit.edu	37	X	44922683	44922683	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:44922683T>C	uc004dge.3	+	16	1919	c.1544T>C	c.(1543-1545)GTT>GCT	p.V515A	KDM6A_uc010nhk.2_Missense_Mutation_p.V481A|KDM6A_uc011mkz.1_Missense_Mutation_p.V567A|KDM6A_uc011mla.1_Missense_Mutation_p.V470A|KDM6A_uc011mlb.1_Missense_Mutation_p.V522A|KDM6A_uc011mlc.1_Missense_Mutation_p.V219A|KDM6A_uc011mld.1_Missense_Mutation_p.V154A	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	515					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						CCAACAGGAGTTGCACAGGTA	0.458			D|N|F|S		renal|oesophageal SCC|MM								7	32					0	0	0.003080	0	0
WDR13	64743	broad.mit.edu	37	X	48463396	48463396	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:48463396C>T	uc004dkh.1	+	10	1581	c.1434C>T	c.(1432-1434)ATC>ATT	p.I478I	WDR13_uc004dki.1_Silent_p.I386I|WDR13_uc004dkj.1_Silent_p.I478I|WDR13_uc004dkk.1_Silent_p.I386I|WDR13_uc004dkl.3_Silent_p.I386I	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	478	WD 5.					cytoplasm|nucleus				ovary(2)	2						GCATGGTCATCGTCTGGAGGC	0.587													4	21					0	0	0.014758	0	0
CACNA1F	778	broad.mit.edu	37	X	49065103	49065103	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:49065103C>T	uc004dnb.2	-	43	5090	c.5028G>A	c.(5026-5028)GGG>GGA	p.G1676G	CACNA1F_uc010nip.2_Silent_p.G1665G	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1676	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	ACACAGAAATCCCGGAGCCCC	0.582													7	60					0	0	0.001984	0	0
CCNB3	85417	broad.mit.edu	37	X	50053595	50053595	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:50053595G>A	uc004dox.3	+	6	2724	c.2426G>A	c.(2425-2427)AGC>AAC	p.S809N	CCNB3_uc004doy.2_Missense_Mutation_p.S809N|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	809					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GAGGAGCCCAGCATTGAGAAG	0.547													5	23					0	0	0.014758	0	0
GSPT2	23708	broad.mit.edu	37	X	51488447	51488447	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:51488447C>T	uc004dpl.2	+	1	1951	c.1725C>T	c.(1723-1725)TTC>TTT	p.F575F		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	575					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					GACCCCGCTTCGTGAAACAAG	0.413													10	44					0	0	0.008291	0	0
SPANXN5	494197	broad.mit.edu	37	X	52825576	52825576	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:52825576C>T	uc004drc.1	-	2	171	c.171G>A	c.(169-171)AGG>AGA	p.R57R		NM_001009616	NP_001009616	Q5MJ07	SPXN5_HUMAN	SPANX family, member N5	57											0	Ovarian(276;0.236)					TCTTAGTCTTCCTGTAGCACA	0.428													6	52					0	0	0.001168	0	0
ARR3	407	broad.mit.edu	37	X	69489979	69489979	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:69489979T>A	uc004dyb.2	+	5	198	c.130T>A	c.(130-132)TTA>ATA	p.L44I	ARR3_uc004dya.2_Missense_Mutation_p.L44I	NM_004312	NP_004303	P36575	ARRC_HUMAN	arrestin 3, retinal (X-arrestin)	44					signal transduction|visual perception	cytoplasm|soluble fraction				large_intestine(2)|ovary(2)	4						TCCTGAGTACTTAAAATGTCG	0.438													9	62					0	0	0.006214	0	0
IL2RG	3561	broad.mit.edu	37	X	70328136	70328136	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:70328136C>T	uc004dyw.1	-	7	929	c.915G>A	c.(913-915)GGG>GGA	p.G305G	CXorf65_uc011mpo.1_5'Flank|CXorf65_uc011mpp.1_5'Flank|IL2RG_uc004dyv.1_Silent_p.G34G|IL2RG_uc004dyx.1_Silent_p.G115G	NM_000206	NP_000197	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma precursor	305	Cytoplasmic (Potential).				immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			pancreas(1)	1	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	CCGAAAAGTTCCCGTGGTATT	0.537									Severe_Combined_Immunodeficiency_X-linked				5	50					0	0	0.001984	0	0
CXCR3	2833	broad.mit.edu	37	X	70836525	70836525	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:70836525A>C	uc004eaf.2	-	2	865	c.797T>G	c.(796-798)CTC>CGC	p.L266R	BCYRN1_uc011mpt.1_Intron|CXCR3_uc011mpx.1_Missense_Mutation_p.L313R	NM_001504	NP_001495	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3 isoform A	266	Helical; Name=6; (Potential).				cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			ovary(2)|central_nervous_system(1)	3	Renal(35;0.156)					GGTCCAGCAGAGGGCAAAGGC	0.662													3	26					0	0	0.009096	0	0
LOC442459	442459	broad.mit.edu	37	X	98974871	98974871	+	RNA	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:98974871G>A	uc011mrd.1	-	8		c.1472C>T				NR_024608				Homo sapiens DNA repair protein mRNA, complete cds.												0						AGACCAGCTGGAAACCTGGAG	0.478													3	19					0	0	0.004672	0	0
TCEAL3	85012	broad.mit.edu	37	X	102864583	102864583	+	Silent	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:102864583C>T	uc004ekq.2	+	3	853	c.591C>T	c.(589-591)ATC>ATT	p.I197I	TCEAL3_uc004ekr.2_Silent_p.I197I	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						TACACGATATCCCATACCTTT	0.527													7	64					0	0	0.003080	0	0
ESX1	80712	broad.mit.edu	37	X	103495484	103495484	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:103495484C>T	uc004ely.2	-	4	704	c.646G>A	c.(646-648)GAC>AAC	p.D216N		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	216					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAGAACATGTCCAAAGGGTGG	0.507													16	114					0	0	0.004007	0	0
COL4A5	1287	broad.mit.edu	37	X	107939566	107939566	+	Silent	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:107939566G>A	uc004enz.1	+	52	5236	c.5034G>A	c.(5032-5034)AGG>AGA	p.R1678R	COL4A5_uc011mso.1_Silent_p.R1675R|COL4A5_uc011msp.1_Silent_p.R354R	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1672	Collagen IV NC1.		Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GAGACTTGAGGACACGAATTA	0.338									Alport_syndrome_with_Diffuse_Leiomyomatosis				5	53					0	0	0.001168	0	0
DOCK11	139818	broad.mit.edu	37	X	117712602	117712602	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:117712602C>T	uc004eqp.2	+	13	1567	c.1504C>T	c.(1504-1506)CCA>TCA	p.P502S	DOCK11_uc004eqq.2_Missense_Mutation_p.P268S	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	502					blood coagulation	cytosol	GTP binding			ovary(3)	3						AAATTCTGATCCAGTAAAGGT	0.343													5	19					0	0	0.014758	0	0
ZBTB33	10009	broad.mit.edu	37	X	119389023	119389023	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:119389023C>T	uc004esn.1	+	2	1981	c.1753C>T	c.(1753-1755)CGT>TGT	p.R585C	ZBTB33_uc010nqm.1_Missense_Mutation_p.R585C	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	585	Interaction with CTNND1 (By similarity).|Required for DNA-binding (By similarity).				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AAAGCTTTATCGTTTACATCC	0.378													8	56					0	0	0.006214	0	0
ODZ1	10178	broad.mit.edu	37	X	123699396	123699396	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:123699396C>T	uc004euj.2	-	12	2156	c.2092G>A	c.(2092-2094)GAG>AAG	p.E698K	ODZ1_uc011muj.1_Missense_Mutation_p.E697K|ODZ1_uc010nqy.2_Missense_Mutation_p.E698K	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	698	Extracellular (Potential).|EGF-like 6.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTACCACACTCCATGGTACAC	0.408													7	29					0	0	0.006214	0	0
IGSF1	3547	broad.mit.edu	37	X	130410995	130410995	+	Silent	SNP	A	C	C			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:130410995A>C	uc004ewd.2	-	14	2764	c.2526T>G	c.(2524-2526)GGT>GGG	p.G842G	IGSF1_uc004ewe.3_Silent_p.G836G|IGSF1_uc004ewf.2_Silent_p.G822G	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	842	Extracellular (Potential).|Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						TCCCTCCATCACCAATGCCCA	0.522													36	238					0	0	0.021022	0	0
SAGE1	55511	broad.mit.edu	37	X	134987465	134987465	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:134987465G>A	uc004ezh.2	+	5	535	c.368G>A	c.(367-369)CGA>CAA	p.R123Q	SAGE1_uc010nry.1_Missense_Mutation_p.R92Q|SAGE1_uc011mvv.1_Missense_Mutation_p.R123Q	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	123										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GGCCAATCTCGAACTGACAAA	0.468													8	55					0	0	0.003080	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935697	151935697	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:151935697G>A	uc004fgp.2	-	3	679	c.470C>T	c.(469-471)TCC>TTC	p.S157F		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	157	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCTGCAAGGAACTGGAAGC	0.547													10	84					0	0	0.006214	0	0
DIP2C	22982	broad.mit.edu	37	10	415480	415482	+	In_Frame_Del	DEL	CTT	-	-			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr10:415480_415482delCTT	uc001ifp.2	-	18	2173_2175	c.2083_2085delAAG	c.(2083-2085)AAGdel	p.K695del	DIP2C_uc009xhi.1_In_Frame_Del_p.K81del|DIP2C_uc010pzz.1_In_Frame_Del_p.K16del	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	695						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GCACGGACAGCTTCTCTTCCGAG	0.562													12	53	---	---	---	---					
DHRS2	10202	broad.mit.edu	37	14	24112393	24112400	+	Frame_Shift_Del	DEL	GCTGCTGA	-	-			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr14:24112393_24112400delGCTGCTGA	uc001wkt.3	+	5	900_907	c.453_460delGCTGCTGA	c.(451-462)CTGCTGCTGAGCfs	p.L151fs	DHRS2_uc010aku.1_3'UTR|DHRS2_uc001wku.3_Frame_Shift_Del_p.L151fs|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Frame_Shift_Del_p.L151fs	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	129_132					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		CCCCAGCCCTGCTGCTGAGCCAGTTGCT	0.577													22	143	---	---	---	---					
ADAM6	8755	broad.mit.edu	37	14	106805656	106805656	+	RNA	DEL	G	-	-	rs112628447		TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr14:106805656delG	uc010tyt.1	-	359		c.13633delC			uc001ysw.1_5'Flank					Parts of antibodies, mostly variable regions.												0						TTCTTGCACAGGAGGTCCAGG	0.502													5	7	---	---	---	---					
MUC20	200958	broad.mit.edu	37	3	195452664	195452664	+	Frame_Shift_Del	DEL	C	-	-			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr3:195452664delC	uc010hzo.2	+	3	803	c.677delC	c.(676-678)ACCfs	p.T226fs	MUC20_uc010hzp.2_Frame_Shift_Del_p.T191fs|MUC20_uc011bte.1_RNA	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	397	12 X 20 AA approximate tandem repeats of S-S-E-S-S-A-S-S-D-S-P-H-P-V-I-T-P-S-R-A.|12; approximate.				protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CCAGTCATCACCCCCTCATGG	0.587													5	1	---	---	---	---					
MLL5	55904	broad.mit.edu	37	7	104753026	104753027	+	Frame_Shift_Ins	INS	-	T	T			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chr7:104753026_104753027insT	uc003vcm.2	+	27	5357_5358	c.4823_4824insT	c.(4822-4824)CATfs	p.H1608fs	MLL5_uc010ljc.2_Frame_Shift_Ins_p.H1608fs|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Frame_Shift_Ins_p.H342fs	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1608	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						ACTCCAGGGCATTTTTTGCCCT	0.535													26	100	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	-	-			TCGA-ER-A199-06A-11D-A197-08	TCGA-ER-A199-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e8511e8-982a-433f-90af-1d2dda8f87a9	7e2d9950-df36-49f3-a893-588120d6eb78	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	uc010njt.2	-	1						NM_018159	NP_060629	Q96G61	NUD11_HUMAN	nudix-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.584										HNSCC(48;0.14)			9	8	---	---	---	---					
