Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NPHP4	261734	broad.mit.edu	37	1	5925288	5925288	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:5925288G>A	uc001alq.1	-	27	3956	c.3690C>T	c.(3688-3690)CTC>CTT	p.L1230L	NPHP4_uc001alr.1_3'UTR	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	1230					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGGGAGTGGAGGTAGACCT	0.642													8	0					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6188922	6188922	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:6188922C>T	uc001amb.1	-	23	3695	c.3595G>A	c.(3595-3597)GAA>AAA	p.E1199K	CHD5_uc001alz.1_Missense_Mutation_p.E56K|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1199					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TTGAAGAGTTCCTCCGTGCCG	0.657													16	20					0	0	1	0	0
TNFRSF9	3604	broad.mit.edu	37	1	7995160	7995160	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:7995160C>T	uc001aot.2	-	6	585	c.457G>A	c.(457-459)GAG>AAG	p.E153K		NM_001561	NP_001552	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily,	153	Extracellular (Potential).|TNFR-Cys 4.				induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		ACGTCCCTCTCCTTCGTCCCA	0.502													21	24					0	0	1	0	0
MASP2	10747	broad.mit.edu	37	1	11094906	11094906	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:11094906G>A	uc001aru.2	-	8	1087	c.1066C>T	c.(1066-1068)CGG>TGG	p.R356W		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	356	Sushi 1.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		GGCATTGGCCGGTCCCAAGAT	0.483													9	14					0	0	1	0	0
C1orf158	93190	broad.mit.edu	37	1	12815710	12815710	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:12815710C>T	uc001auh.2	+	2	388	c.172C>T	c.(172-174)CCA>TCA	p.P58S	C1orf158_uc010obe.1_Missense_Mutation_p.P58S	NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	58										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CATCCCCTTCCCAGACCACAG	0.502													31	25					0	0	1	0	0
KAZ	23254	broad.mit.edu	37	1	15386768	15386768	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:15386768C>T	uc001avm.3	+	6	1298	c.1017C>T	c.(1015-1017)TCC>TCT	p.S339S	KAZ_uc009vog.1_Silent_p.S339S|KAZ_uc010obj.1_Silent_p.S339S|KAZ_uc001avo.2_Silent_p.S333S|KAZ_uc001avp.2_Silent_p.S245S|KAZ_uc001avq.2_Silent_p.S245S|KAZ_uc001avr.2_Silent_p.S242S	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	339					keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						ACATCAACTCCCCTCGACACC	0.706													42	60					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418													6	35					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	17983152	17983152	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:17983152C>T	uc001ban.2	+	25	2968	c.2809C>T	c.(2809-2811)CTG>TTG	p.L937L	ARHGEF10L_uc009vpe.1_Silent_p.L898L|ARHGEF10L_uc001bao.2_Silent_p.L898L|ARHGEF10L_uc001bap.2_Silent_p.L893L|ARHGEF10L_uc001baq.2_Silent_p.L698L|ARHGEF10L_uc010ocs.1_Silent_p.L710L|ARHGEF10L_uc001bar.2_Silent_p.L640L|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	937					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CCCCTTCCACCTGCTCGCTGG	0.662													18	27					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18807831	18807831	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:18807831G>A	uc001bax.2	+	1	408	c.356G>A	c.(355-357)AGA>AAA	p.R119K	KLHDC7A_uc009vpg.2_5'UTR	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	119						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		AAGCCCCAGAGAAAAGGCTCA	0.627													12	10					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	21031117	21031117	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:21031117C>T	uc001bdr.3	-	5	1064	c.946G>A	c.(946-948)GAC>AAC	p.D316N	KIF17_uc001bds.3_Missense_Mutation_p.D316N	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	316					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TAGTTGTTGTCCGCAGGCGAC	0.612													46	13					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21562382	21562382	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:21562382G>A	uc001bek.2	-	13	1602	c.1527C>T	c.(1525-1527)TTC>TTT	p.F509F	ECE1_uc001bem.2_Silent_p.F493F|ECE1_uc001bej.2_Silent_p.F497F|ECE1_uc001bei.2_Silent_p.F506F|ECE1_uc010odl.1_Silent_p.F509F|ECE1_uc009vqa.1_Silent_p.F509F	NM_001397	NP_001388	P42892	ECE1_HUMAN	endothelin converting enzyme 1 isoform 1	509	Extracellular (Potential).				bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			ovary(2)|skin(1)	3		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		GATCCATGATGAAGTTGGGGT	0.552													98	22					0	0	1	0	0
ALPL	249	broad.mit.edu	37	1	21896825	21896825	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:21896825G>A	uc001bet.2	+	8	1077	c.820G>A	c.(820-822)GAA>AAA	p.E274K	ALPL_uc010odn.1_Missense_Mutation_p.E222K|ALPL_uc010odo.1_Missense_Mutation_p.E219K|ALPL_uc010odp.1_Missense_Mutation_p.E197K|ALPL_uc001beu.3_Missense_Mutation_p.E274K	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	274					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	GAACCGCACGGAACTCCTGAC	0.617													20	27					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22816548	22816548	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:22816548G>A	uc001bft.2	+	3	618	c.107G>A	c.(106-108)AGG>AAG	p.R36K	ZBTB40_uc001bfu.2_Missense_Mutation_p.R36K|ZBTB40_uc009vqi.1_Missense_Mutation_p.R36K	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	36	BTB.				bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		ATTTACTTCAGGGCTCACAAG	0.547													57	6					0	0	1	0	0
FUCA1	2517	broad.mit.edu	37	1	24175137	24175137	+	Splice_Site	SNP	A	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:24175137A>C	uc001bie.2	-	6	1205	c.1160_splice	c.e6+1	p.W387_splice		NM_000147	NP_000138	P04066	FUCO_HUMAN	fucosidase, alpha-L-1, tissue precursor						fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		GACAAGACTCACCATACAGAT	0.502													38	5					0	0	1	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33945142	33945142	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:33945142C>T	uc001bxj.3	+	2	420	c.253C>T	c.(253-255)CGT>TGT	p.R85C	ZSCAN20_uc001bxk.2_Missense_Mutation_p.R85C|ZSCAN20_uc009vui.2_Missense_Mutation_p.R85C	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	85	SCAN box.				viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GCCGGAGATCCGTCTCAAAGA	0.612													26	3					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34164509	34164509	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:34164509G>A	uc001bxn.1	-	24	3678	c.3649C>T	c.(3649-3651)CCC>TCC	p.P1217S	CSMD2_uc001bxm.1_Missense_Mutation_p.P1257S|CSMD2_uc001bxo.1_Missense_Mutation_p.P130S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1217	Sushi 7.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCAAACTTGGGGGTTCCTGGG	0.512													23	30					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370292	35370292	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:35370292G>A	uc001byc.2	-	1	693	c.693C>T	c.(691-693)CAC>CAT	p.H231H		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	231	Poly-His.				cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				ggtggtggtggtgatggtggt	0.547													29	38					0	0	1	0	0
ZMYM1	79830	broad.mit.edu	37	1	35579758	35579758	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:35579758A>G	uc001bym.2	+	11	2475	c.2327A>G	c.(2326-2328)AAC>AGC	p.N776S	ZMYM1_uc001byn.2_Missense_Mutation_p.N776S|ZMYM1_uc010ohu.1_Missense_Mutation_p.N757S|ZMYM1_uc001byo.2_Missense_Mutation_p.N416S|ZMYM1_uc009vut.2_Missense_Mutation_p.N701S	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	776						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TCTTTGTTCAACACTATTTGT	0.313													32	4					0	0	1	0	0
MTF1	4520	broad.mit.edu	37	1	38283093	38283093	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:38283093G>A	uc001cce.1	-	10	1970	c.1829C>T	c.(1828-1830)CCA>CTA	p.P610L		NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	610						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TTACATACCTGGGCTACTGGC	0.393													149	29					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39788337	39788337	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:39788337C>T	uc010ois.1	+	33	4307	c.4102C>T	c.(4102-4104)CCT>TCT	p.P1368S	MACF1_uc001cda.1_Missense_Mutation_p.P1276S|MACF1_uc001cdc.1_Missense_Mutation_p.P455S|MACF1_uc009vvq.1_Missense_Mutation_p.P425S|MACF1_uc001cdb.1_Missense_Mutation_p.P455S	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1368					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCAGAAATCCCCTGGCAAGCG	0.473													33	45					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39801114	39801114	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:39801114G>A	uc010oiu.1	+	1	4305	c.4174G>A	c.(4174-4176)GAA>AAA	p.E1392K	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2957					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AACATATTGTGAAACGTCAGG	0.393													30	4					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39908455	39908455	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:39908455C>A	uc010oiu.1	+	43	14634	c.14503C>A	c.(14503-14505)CTT>ATT	p.L4835I	MACF1_uc010ois.1_Missense_Mutation_p.L4333I	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	6401	Spectrin 13.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAATGAGCTTCTTGAATCCAG	0.438													11	17					4.3838e-07	4.40523e-07	1	1	0
MFSD2A	84879	broad.mit.edu	37	1	40420974	40420974	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:40420974G>A	uc001cev.2	+	1	191	c.10G>A	c.(10-12)GGA>AGA	p.G4R	MFSD2A_uc010ojb.1_Missense_Mutation_p.G4R|MFSD2A_uc001ceu.2_Missense_Mutation_p.G4R|MFSD2A_uc010ojc.1_5'UTR|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cew.1_Missense_Mutation_p.G4R	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	4					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						CATGGCCAAAGGAGAAGGCGC	0.706													6	2					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43119114	43119114	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:43119114G>A	uc009vwk.1	+	15	2251	c.2141G>A	c.(2140-2142)AGT>AAT	p.S714N	CCDC30_uc001chm.2_Missense_Mutation_p.S412N|CCDC30_uc001chn.2_Missense_Mutation_p.S503N	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	714											0						TCAAACTCCAGGTTAGTAAAG	0.393													12	31					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47279172	47279172	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:47279172G>A	uc001cqm.3	+	5	598	c.514G>A	c.(514-516)GCT>ACT	p.A172T	CYP4B1_uc009vyl.1_Missense_Mutation_p.A9T|CYP4B1_uc001cqn.3_Missense_Mutation_p.A172T|CYP4B1_uc009vym.2_Missense_Mutation_p.A157T|CYP4B1_uc010omk.1_Missense_Mutation_p.A9T|CYP4B1_uc010oml.1_Missense_Mutation_p.A9T	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	172					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					GGAAGAGAAAGCTCGGGAGGG	0.572													15	24					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47571800	47571801	+	Nonsense_Mutation	DNP	GG	AA	AA	rs149156333		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:47571800_47571801GG>AA	uc001cqu.1	+	9	1071_1072	c.1068_1069GG>AA	c.(1066-1071)TGGGAA>TGAAAA	p.356_357WE>*K		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	356_357	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						TTCTACCCAGGGAACACCTGAG	0.48													27	40					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57415351	57415351	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:57415351T>G	uc001cyp.2	-	6	808	c.741A>C	c.(739-741)AAA>AAC	p.K247N	C8B_uc010oon.1_Missense_Mutation_p.K185N|C8B_uc010ooo.1_Missense_Mutation_p.K195N	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	247	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TGCTTGCCATTTTCTCTGTGA	0.343													16	15					0	0	1	0	0
TACSTD2	4070	broad.mit.edu	37	1	59042193	59042193	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:59042193C>T	uc001cyz.3	-	1	974	c.636G>A	c.(634-636)AAG>AAA	p.K212K		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	212	Extracellular (Potential).				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					CACCGGCGGCCTTCTGAGACG	0.647													4	5					0	0	1	0	0
MYSM1	114803	broad.mit.edu	37	1	59147987	59147987	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:59147987A>G	uc009wab.1	-	8	752	c.729T>C	c.(727-729)AGT>AGC	p.S243S	MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	243					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					ACAAGAGATCACTGCTAGAAT	0.378													65	10					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66102286	66102286	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:66102286G>A	uc001dci.2	+	20	3288	c.3086G>A	c.(3085-3087)TGG>TAG	p.W1029*	LEPR_uc009waq.2_3'UTR	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	1029	Cytoplasmic (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		AATAGCTCATGGGAGATAGAG	0.388													51	61					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037295	75037295	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:75037295C>T	uc001dgg.2	-	14	4318	c.4099G>A	c.(4099-4101)GAG>AAG	p.E1367K		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1367	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTTTTCTCCTCGGCTGTCTCC	0.517													70	18					0	0	1	0	0
CRYZ	1429	broad.mit.edu	37	1	75184934	75184934	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:75184934G>A	uc001dgk.2	-	5	892	c.387C>T	c.(385-387)ATC>ATT	p.I129I	CRYZ_uc001dgj.2_Silent_p.I129I|CRYZ_uc001dgl.2_Silent_p.I129I|CRYZ_uc001dgm.2_Intron	NM_001130042	NP_001123514	Q08257	QOR_HUMAN	crystallin, zeta isoform a	129					protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)	ATGGAATGCCGATGGCAGCTC	0.443													40	6					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75862300	75862300	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:75862300G>A	uc001dgu.2	-	3	164	c.20C>T	c.(19-21)CCA>CTA	p.P7L	SLC44A5_uc001dgt.2_Missense_Mutation_p.P7L|SLC44A5_uc001dgs.2_5'UTR|SLC44A5_uc001dgr.2_5'UTR|SLC44A5_uc010oqz.1_Missense_Mutation_p.P46L|SLC44A5_uc010ora.1_Intron|SLC44A5_uc010orb.1_5'UTR	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	7	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						AGTATCTGCTGGTTTTTCTAG	0.368													53	8					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76344712	76344712	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:76344712C>T	uc001dhd.1	+	12	1617	c.1576C>T	c.(1576-1578)CCT>TCT	p.P526S		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	526					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						ATATAGTCTACCTTTAAGGAC	0.318								MMR					29	4					0	0	1	0	0
GIPC2	54810	broad.mit.edu	37	1	78601371	78601371	+	Missense_Mutation	SNP	G	A	A	rs138793126		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:78601371G>A	uc001dik.2	+	6	1082	c.892G>A	c.(892-894)GAA>AAA	p.E298K		NM_017655	NP_060125	Q8TF65	GIPC2_HUMAN	PDZ domain protein GIPC2	298						cytoplasm				ovary(1)	1						GTTCCCAGACGAATTTGTCTT	0.423													14	22					0	0	1	0	0
IFI44L	10964	broad.mit.edu	37	1	79093950	79093950	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:79093950C>T	uc010oro.1	+	2	529	c.350C>T	c.(349-351)TCG>TTG	p.S117L	IFI44L_uc010orp.1_Intron|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	117						cytoplasm					0						TGTCGTTTATCGAAAACGGAT	0.303													16	3					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82437561	82437561	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:82437561T>A	uc001dit.3	+	16	3110	c.2929T>A	c.(2929-2931)TTT>ATT	p.F977I	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.F977I|LPHN2_uc001div.2_Missense_Mutation_p.F977I|LPHN2_uc009wcd.2_Missense_Mutation_p.F977I|LPHN2_uc001diw.2_Missense_Mutation_p.F561I|LPHN2_uc009wce.1_Missense_Mutation_p.F63I	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	990	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TGATAACTACTTTATATGGAG	0.353													12	20					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86524851	86524851	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:86524851G>A	uc001dlj.2	-	9	1801	c.1759C>T	c.(1759-1761)CCA>TCA	p.P587S	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.P587S	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	587	Collagen-like 2.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GCAAATCCTGGAATTCCCTGA	0.338													8	12					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94520757	94520757	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:94520757C>T	uc001dqh.2	-	16	2601	c.2497G>A	c.(2497-2499)GAA>AAA	p.E833K	ABCA4_uc010otn.1_Missense_Mutation_p.E759K	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	833					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AAGCTGAATTCGTCCCCTTCC	0.537													42	7					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100350249	100350249	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:100350249C>T	uc001dsi.1	+	20	3071	c.2671C>T	c.(2671-2673)CCT>TCT	p.P891S	AGL_uc001dsj.1_Missense_Mutation_p.P891S|AGL_uc001dsk.1_Missense_Mutation_p.P891S|AGL_uc001dsl.1_Missense_Mutation_p.P891S|AGL_uc001dsm.1_Missense_Mutation_p.P875S|AGL_uc001dsn.1_Missense_Mutation_p.P874S	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	891	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		ATTAAAAATTCCTTTTGCTTC	0.373													35	4					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101196957	101196957	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:101196957T>C	uc001dti.2	+	6	1528	c.1408T>C	c.(1408-1410)TTC>CTC	p.F470L	VCAM1_uc001dtj.2_Missense_Mutation_p.F378L|VCAM1_uc010ouj.1_Missense_Mutation_p.F408L	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	470	Ig-like C2-type 5.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GGAAATGACCTTCATCCCTAC	0.388													20	29					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103377722	103377722	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:103377722C>T	uc001dul.2	-	54	4397	c.4079G>A	c.(4078-4080)GGA>GAA	p.G1360E	COL11A1_uc001duk.2_Missense_Mutation_p.G556E|COL11A1_uc001dum.2_Missense_Mutation_p.G1372E|COL11A1_uc001dun.2_Missense_Mutation_p.G1321E|COL11A1_uc009weh.2_Missense_Mutation_p.G1244E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1360	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TACTCGTTTTCCAGGAGGACC	0.383													12	4					0	0	1	0	0
SORT1	6272	broad.mit.edu	37	1	109883350	109883350	+	Silent	SNP	G	A	A	rs150785768		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:109883350G>A	uc001dxm.1	-	10	1309	c.1260C>T	c.(1258-1260)TCC>TCT	p.S420S	SORT1_uc010ovi.1_Silent_p.S283S	NM_002959	NP_002950	Q99523	SORT_HUMAN	sortilin 1 preproprotein	420	Extracellular (Potential).				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		ACTCACCTTCGGAGAGCACGC	0.557													108	137					0	0	1	0	0
KCNA2	3737	broad.mit.edu	37	1	111145957	111145957	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:111145957G>A	uc001dzu.2	-	2	1944	c.1448C>T	c.(1447-1449)ACC>ATC	p.T483I	KCNA2_uc009wfv.1_Intron|KCNA2_uc009wfw.2_Missense_Mutation_p.T483I	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	483						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		GTTAGCCAAGGTACAGTTGGC	0.383													54	11					0	0	1	0	0
RSBN1	54665	broad.mit.edu	37	1	114320371	114320371	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:114320371G>A	uc001edq.2	-	3	1473	c.1437C>T	c.(1435-1437)CTC>CTT	p.L479L	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	479						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGCTCCAACGAGACTTATCT	0.403													41	5					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256528	115256528	+	Missense_Mutation	SNP	T	A	A	rs121913255		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:115256528T>A	uc009wgu.2	-	3	437	c.183A>T	c.(181-183)CAA>CAT	p.Q61H		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGTACTCTTCTTGTCCAGCTG	0.463	Q61H(ME1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61H(RD_SOFT_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			109	10					0	0	1	0	0
CD101	9398	broad.mit.edu	37	1	117554315	117554315	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:117554315G>A	uc010oxb.1	+	3	626	c.568G>A	c.(568-570)GGA>AGA	p.G190R	CD101_uc009whd.2_Missense_Mutation_p.G190R|CD101_uc010oxc.1_Missense_Mutation_p.G190R|CD101_uc010oxd.1_Intron	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	190	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						AACACAGGATGGAGGAGGAAG	0.512													18	35					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119469224	119469224	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:119469224G>A	uc001ehl.1	-	3	427	c.112C>T	c.(112-114)CCT>TCT	p.P38S		NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	144	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CTCATGGCAGGAAACATCCTC	0.393													4	15					0	0	1	0	0
PPIAL4G	644591	broad.mit.edu	37	1	143767794	143767794	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:143767794G>A	uc001ejt.2	-	1	88	c.55C>T	c.(55-57)CGC>TGC	p.R19C		NM_001123068	NP_001116540	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like	19	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity				0						ATGGAGATGCGGCCCAAGGGC	0.493													105	120					0	0	1	0	0
NBPF9	400818	broad.mit.edu	37	1	144828697	144828697	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:144828697C>T	uc009wig.1	+	23	2818	c.2742C>T	c.(2740-2742)TTC>TTT	p.F914F	NBPF9_uc010oxn.1_Silent_p.F812F|NBPF9_uc010oxo.1_Silent_p.F839F|NBPF9_uc010oxr.1_Silent_p.F941F|NBPF9_uc010oxt.1_Silent_p.F729F|NBPF9_uc001ekg.1_Silent_p.F241F|NBPF9_uc001ekk.1_Silent_p.F485F|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Silent_p.F241F|NBPF9_uc010oye.1_Intron|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Silent_p.F574F|uc001elr.3_5'Flank	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	914	NBPF 7.					cytoplasm					0						ACATCAGCTTCGCCCTTTACG	0.428													7	199					0	0	1	0	0
TNFAIP8L2	79626	broad.mit.edu	37	1	151131694	151131694	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:151131694G>A	uc001ewx.2	+	2	647	c.521G>A	c.(520-522)GGA>GAA	p.G174E		NM_024575	NP_078851	Q6P589	TP8L2_HUMAN	tumor necrosis factor, alpha-induced protein	174					innate immune response						0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ATCTGTGACGGACTCAGGAAG	0.542													24	15					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127657	152127657	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:152127657C>T	uc001ezs.1	-	3	1983	c.1918G>A	c.(1918-1920)GAC>AAC	p.D640N		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	640	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						TGCTGTGAGTCCCTAGACTGG	0.493													48	111					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127941	152127941	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:152127941G>A	uc001ezs.1	-	3	1699	c.1634C>T	c.(1633-1635)TCC>TTC	p.S545F		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	545	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						ACCATAGTGGGAACTCTGGCC	0.527													468	332					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152323642	152323642	+	Missense_Mutation	SNP	C	T	T	rs146579981		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:152323642C>T	uc001ezw.3	-	3	6693	c.6620G>A	c.(6619-6621)CGA>CAA	p.R2207Q	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2207							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCCATGTCGAGATCCGGC	0.512													200	124					0	0	1	0	0
LCE1F	353137	broad.mit.edu	37	1	152748899	152748899	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:152748899C>T	uc010pdv.1	+	1	52	c.52C>T	c.(52-54)CCC>TCC	p.P18S		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	18	Pro-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			caagtgcactcccaagtgccc	0.368													20	15					0	0	1	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153276351	153276351	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:153276351G>A	uc001fbn.1	-	4	564	c.511C>T	c.(511-513)CCA>TCA	p.P171S		NM_052891	NP_443123	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3 precursor	171					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGCATCACTGGATGTTGAGGG	0.532													82	59					0	0	1	0	0
S100A12	6283	broad.mit.edu	37	1	153347040	153347040	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:153347040C>T	uc001fbr.1	-	2	97	c.29G>A	c.(28-30)GGA>GAA	p.G10E		NM_005621	NP_005612	P80511	S10AC_HUMAN	S100 calcium-binding protein A12	10					defense response to bacterium|defense response to fungus|inflammatory response|innate immune response|killing of cells of other organism|positive regulation of I-kappaB kinase/NF-kappaB cascade|xenobiotic metabolic process	cytosol|extracellular region|insoluble fraction|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	ATTGACAATTCCCTCCAGATG	0.478													47	109					0	0	1	0	0
UBAP2L	9898	broad.mit.edu	37	1	154229842	154229842	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:154229842C>T	uc001fep.3	+	20	2541	c.2374C>T	c.(2374-2376)CCT>TCT	p.P792S	UBAP2L_uc009wot.2_Missense_Mutation_p.P792S|UBAP2L_uc010pek.1_Missense_Mutation_p.P784S|UBAP2L_uc010pel.1_Missense_Mutation_p.P802S|UBAP2L_uc010pen.1_Missense_Mutation_p.P706S|UBAP2L_uc001feq.2_5'UTR|UBAP2L_uc001fer.2_5'UTR	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	792					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCCCAACCTCCCTCCTGGGGT	0.473													32	29					0	0	1	0	0
DCST1	149095	broad.mit.edu	37	1	155014062	155014062	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:155014062G>A	uc001fgn.1	+	7	817	c.721G>A	c.(721-723)GAG>AAG	p.E241K	DCST1_uc010per.1_Missense_Mutation_p.E266K|DCST1_uc010pes.1_Missense_Mutation_p.E216K	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	241	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GAAGATGTATGAGCTGAAGAC	0.617													55	42					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156504511	156504511	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:156504511G>A	uc001fpf.2	-	29	3597	c.3522C>T	c.(3520-3522)CTC>CTT	p.L1174L		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1174	Ras-GAP.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGTAGTACAGGAGGTTCCCGA	0.612													4	14					0	0	1	0	0
ISG20L2	81875	broad.mit.edu	37	1	156694030	156694030	+	Silent	SNP	G	A	A	rs141168468	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:156694030G>A	uc001fps.1	-	2	1119	c.858C>T	c.(856-858)ATC>ATT	p.I286I	ISG20L2_uc001fpt.1_Silent_p.I286I	NM_030980	NP_112242	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene	286	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGAGGGGGGGGATATGGGAGG	0.552													26	73					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156927605	156927605	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:156927605G>A	uc001fqo.2	-	17	2425	c.1385C>T	c.(1384-1386)TCC>TTC	p.S462F	ARHGEF11_uc001fqn.2_Missense_Mutation_p.S502F|ARHGEF11_uc001fqp.1_5'Flank	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	462	RGSL.|Potential.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTCATACTTGGACCTGGAATG	0.463													71	43					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157514230	157514230	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:157514230G>A	uc001fqu.2	-	5	824	c.666C>T	c.(664-666)GTC>GTT	p.V222V	FCRL5_uc009wsm.2_Silent_p.V222V|FCRL5_uc010phv.1_Silent_p.V222V|FCRL5_uc010phw.1_Silent_p.V137V|FCRL5_uc001fqv.1_Silent_p.V222V|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	222	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				ACCGGAGCGGGACATCTGACC	0.557													66	123					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157773723	157773723	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:157773723C>T	uc001frg.2	-	3	344	c.231G>A	c.(229-231)TGG>TGA	p.W77*	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Nonsense_Mutation_p.W77*|FCRL1_uc001fri.2_Nonsense_Mutation_p.W77*|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	77	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGTCTTCTTTCCACATGGCAG	0.552													68	56					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158226687	158226687	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:158226687G>A	uc001frt.2	+	4	1249	c.716G>A	c.(715-717)CGG>CAG	p.R239Q		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	239	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	ATGTGGATGCGGGGTGAGCAG	0.642													24	77					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158324383	158324383	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:158324383A>G	uc001fse.2	+	2	514	c.275A>G	c.(274-276)AAC>AGC	p.N92S	CD1E_uc010pid.1_Missense_Mutation_p.N90S|CD1E_uc010pie.1_Intron|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.N92S|CD1E_uc001fsk.2_Missense_Mutation_p.N92S|CD1E_uc001fsj.2_Missense_Mutation_p.N92S|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.N92S|CD1E_uc001fry.2_Missense_Mutation_p.N92S|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.N92S|CD1E_uc009wsv.2_Intron|CD1E_uc001frz.2_Missense_Mutation_p.N92S|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	92					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					GAGCTGAAAAACTTACAGTCA	0.478													17	37					0	0	1	0	0
OR10K2	391107	broad.mit.edu	37	1	158390626	158390626	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:158390626C>T	uc010pii.1	-	1	31	c.31G>A	c.(31-33)GAG>AAG	p.E11K		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AAGATGACCTCTCTCACCACA	0.502													40	21					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158436048	158436048	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:158436048G>A	uc010pij.1	+	1	697	c.697G>A	c.(697-699)GGA>AGA	p.G233R		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TTCCTCCGTTGGAAGATACAA	0.443													65	45					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158436122	158436122	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:158436122C>T	uc010pij.1	+	1	771	c.771C>T	c.(769-771)TTC>TTT	p.F257F		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GTGCCTCTTTCATCTACTTAA	0.423													67	44					0	0	1	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517122	158517122	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:158517122G>A	uc010pil.1	-	1	774	c.774C>T	c.(772-774)TCC>TCT	p.S258S		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	258	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AAAGTGTCATGGAATAGAAGA	0.498													34	88					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158617356	158617356	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:158617356T>A	uc001fst.1	-	27	4068	c.3869A>T	c.(3868-3870)AAA>ATA	p.K1290I		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1290	Spectrin 13.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CAGGTAGAATTTCTGGGCCTC	0.537													87	61					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158736179	158736179	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:158736179G>A	uc010piq.1	-	1	294	c.294C>T	c.(292-294)CTC>CTT	p.L98L		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGATCTGCAGGAGACACCCAG	0.498													20	63					0	0	1	0	0
APCS	325	broad.mit.edu	37	1	159557917	159557917	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:159557917C>T	uc001ftv.2	+	2	187	c.91C>T	c.(91-93)CCT>TCT	p.P31S		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	31	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					GTTTGTATTTCCTAGAGAATC	0.408													56	51					0	0	1	0	0
CCDC19	25790	broad.mit.edu	37	1	159860322	159860322	+	Missense_Mutation	SNP	G	A	A	rs62640918	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:159860322G>A	uc001fui.2	-	3	238	c.220C>T	c.(220-222)CGC>TGC	p.R74C	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_5'UTR|CCDC19_uc001ful.2_5'UTR|CCDC19_uc009wtc.1_Missense_Mutation_p.R74C	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	74						mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TCTGGCTTGCGATCCAAGCCC	0.552													58	109					0	0	1	0	0
USP21	27005	broad.mit.edu	37	1	161130677	161130677	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:161130677C>T	uc010pke.1	+	3	624	c.247C>T	c.(247-249)CGA>TGA	p.R83*	USP21_uc010pkc.1_Nonsense_Mutation_p.R83*|USP21_uc010pkd.1_Nonsense_Mutation_p.R83*|USP21_uc010pkf.1_Nonsense_Mutation_p.R83*	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	83					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			AGGCCCCCTTCGAGCAGATCA	0.637													42	37					0	0	1	0	0
PBX1	5087	broad.mit.edu	37	1	164789402	164789402	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:164789402G>A	uc001gct.2	+	7	1349	c.1091G>A	c.(1090-1092)GGA>GAA	p.G364E	PBX1_uc010pku.1_Missense_Mutation_p.G364E|PBX1_uc010pkv.1_Missense_Mutation_p.G281E|PBX1_uc001gcs.2_Intron|PBX1_uc010pkw.1_Missense_Mutation_p.G254E	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	364					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						GCCCAGGTTGGAGCCAACGTG	0.488			T	TCF3|EWSR1	pre B-ALL|myoepithelioma								43	41					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165218761	165218761	+	Missense_Mutation	SNP	C	T	T	rs150222420		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:165218761C>T	uc001gcy.1	-	3	601	c.380G>A	c.(379-381)CGA>CAA	p.R127Q	LMX1A_uc001gcz.1_Missense_Mutation_p.R127Q	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	127	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CTGAAGCTGTCGCTCGCAGAC	0.582													23	63					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167654684	167654684	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:167654684G>A	uc001gem.2	+	3	322	c.135G>A	c.(133-135)AGG>AGA	p.R45R	RCSD1_uc010pli.1_Intron	NM_052862	NP_443094	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	45								p.R45R(1)		ovary(2)|central_nervous_system(2)|skin(1)	5	all_hematologic(923;0.215)					CAACCCGAAGGAAACCGCCCT	0.577													17	45					0	0	1	0	0
FMO4	2329	broad.mit.edu	37	1	171310953	171310953	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:171310953A>T	uc001gho.2	+	10	1869	c.1652A>T	c.(1651-1653)TAC>TTC	p.Y551F		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	551					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					ATGTCCCCTTACCTAGTAAGT	0.323													16	30					0	0	1	0	0
SLC9A11	284525	broad.mit.edu	37	1	173523928	173523928	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:173523928G>A	uc001giz.2	-	11	1664	c.1241C>T	c.(1240-1242)TCA>TTA	p.S414L	SLC9A11_uc009wwe.2_Intron|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	414	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TGTCAATAATGATATTACTTG	0.308													40	109					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525995	176525995	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:176525995C>T	uc001gkz.2	+	2	1701	c.537C>T	c.(535-537)ACC>ACT	p.T179T	PAPPA2_uc001gky.1_Silent_p.T179T|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	179					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TTTTCACAACCCTGAACGAAC	0.577													74	60					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668454	176668455	+	Missense_Mutation	DNP	GA	AC	AC			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:176668454_176668455GA>AC	uc001gkz.2	+	8	4129_4130	c.2965_2966GA>AC	c.(2965-2967)GAA>ACA	p.E989T	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	989					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GATCTTGCTGGAAAACAAGGAG	0.554													64	191					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668661	176668661	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:176668661G>A	uc001gkz.2	+	8	4336	c.3172G>A	c.(3172-3174)GAT>AAT	p.D1058N	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1058					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GGTTCTCCGCGATCCCCCATT	0.552													60	147					0	0	1	0	0
FAM5B	57795	broad.mit.edu	37	1	177249819	177249819	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:177249819C>T	uc001glf.2	+	8	1819	c.1507C>T	c.(1507-1509)CTT>TTT	p.L503F	FAM5B_uc001glg.2_Missense_Mutation_p.L398F	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	503						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GGAAAACTTTCTTGGGCTGGA	0.572													29	24					0	0	1	0	0
C1orf125	126859	broad.mit.edu	37	1	179414258	179414258	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:179414258G>A	uc001gmo.2	+	16	1844	c.1717G>A	c.(1717-1719)GAG>AAG	p.E573K	C1orf125_uc009wxg.2_Intron|C1orf125_uc001gmn.1_Missense_Mutation_p.E361K|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.E573K	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	573	Potential.										0						GATGCCATCAGAGCGACAGTA	0.348													27	27					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181724526	181724526	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:181724526G>A	uc001gow.2	+	28	4147	c.3982G>A	c.(3982-3984)GAG>AAG	p.E1328K	CACNA1E_uc009wxs.2_Missense_Mutation_p.E1216K|CACNA1E_uc001gox.1_Missense_Mutation_p.E554K|CACNA1E_uc009wxt.2_Missense_Mutation_p.E554K	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1328	Extracellular (Potential).|III.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CACAGAGAAGGAGTGCATGTA	0.483													51	118					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181767591	181767591	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:181767591G>A	uc001gow.2	+	47	6599	c.6434G>A	c.(6433-6435)GGA>GAA	p.G2145E	CACNA1E_uc009wxs.2_Missense_Mutation_p.G2033E|CACNA1E_uc009wxt.2_Missense_Mutation_p.G1414E	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2188	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CCTGCTGATGGAAGCGAGGAG	0.637													31	60					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181767819	181767819	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:181767819A>G	uc001gow.2	+	47	6827	c.6662A>G	c.(6661-6663)AAC>AGC	p.N2221S	CACNA1E_uc009wxs.2_Missense_Mutation_p.N2109S|CACNA1E_uc009wxt.2_Missense_Mutation_p.N1490S	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	2264	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GGCCGTTCCAACACCATCGGC	0.662													14	12					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186332546	186332546	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:186332546T>C	uc001grv.2	-	5	756	c.459A>G	c.(457-459)AAA>AAG	p.K153K	TPR_uc010pop.1_Silent_p.K229K	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	153	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TATTGCTTTCTTTAAGTTTTT	0.313			T	NTRK1	papillary thyroid								34	21					0	0	1	0	0
TROVE2	6738	broad.mit.edu	37	1	193045023	193045023	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:193045023C>T	uc001gss.2	+	3	829	c.654C>T	c.(652-654)CTC>CTT	p.L218L	TROVE2_uc001gst.1_Intron|TROVE2_uc001gsu.1_5'UTR|TROVE2_uc001gsv.1_Silent_p.L218L|TROVE2_uc001gsw.2_Silent_p.L218L|TROVE2_uc009wyp.2_Silent_p.L218L|TROVE2_uc009wyq.2_Silent_p.L218L|TROVE2_uc001gsx.1_Silent_p.L218L	NM_004600	NP_004591	P10155	RO60_HUMAN	TROVE domain family, member 2 isoform 2	218	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding				0						AAAAAGCACTCTCTGTGGAGA	0.338													30	91					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196311220	196311220	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:196311220A>G	uc001gtd.1	-	15	1602	c.1542T>C	c.(1540-1542)CAT>CAC	p.H514H	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Intron|KCNT2_uc001gtf.1_Silent_p.H514H|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Silent_p.H514H|KCNT2_uc001gth.1_Silent_p.H35H	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	514	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TTTTGTGTGCATGGAAAGAGG	0.333													33	20					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196395036	196395036	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:196395036C>T	uc001gtd.1	-	11	1127	c.1067G>A	c.(1066-1068)CGA>CAA	p.R356Q	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.R356Q|KCNT2_uc001gtf.1_Missense_Mutation_p.R356Q|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.R356Q|KCNT2_uc009wyv.1_Missense_Mutation_p.R331Q	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	356	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						GTAGATAACTCGTTGGGACCA	0.413													33	22					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196646674	196646674	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:196646674C>T	uc001gtj.3	+	5	736	c.496C>T	c.(496-498)CGG>TGG	p.R166W	CFH_uc001gti.3_Missense_Mutation_p.R166W|CFH_uc009wyw.2_Missense_Mutation_p.R166W|CFH_uc009wyx.2_Intron	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	166	Sushi 3.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GGAACCAGATCGGGAATACCA	0.393													41	32					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196964873	196964873	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:196964873C>T	uc001gts.3	+	5	762	c.634C>T	c.(634-636)CCT>TCT	p.P212S		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	212	Sushi 4.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TGGTCCACCTCCTCAACTCTC	0.318													52	37					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196964900	196964900	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:196964900G>A	uc001gts.3	+	5	789	c.661G>A	c.(661-663)GAG>AAG	p.E221K		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	221	Sushi 4.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TGAAGTTAAGGAGATAAGAAA	0.343													53	35					0	0	1	0	0
TNNT2	7139	broad.mit.edu	37	1	201334340	201334340	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:201334340G>A	uc001gwf.2	-	10	459	c.390C>T	c.(388-390)CTC>CTT	p.L130L	TNNT2_uc001gwg.2_Silent_p.L120L|TNNT2_uc001gwh.2_Silent_p.L115L|TNNT2_uc001gwi.2_Intron|TNNT2_uc009wzr.2_Silent_p.L61L|TNNT2_uc001gwj.1_5'Flank|TNNT2_uc009wzs.1_Silent_p.L95L|TNNT2_uc001gwk.1_Silent_p.L61L|TNNT2_uc009wzt.1_Silent_p.L120L	NM_000364	NP_000355	P45379	TNNT2_HUMAN	troponin T type 2, cardiac isoform 1	130					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding				0						TGAGAGAAACGAGCTCCTCCT	0.522													55	92					0	0	1	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202533586	202533586	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:202533586C>T	uc001gya.1	+	21	2812	c.2668C>T	c.(2668-2670)CTG>TTG	p.L890L	PPP1R12B_uc001gxz.1_Silent_p.L890L|PPP1R12B_uc001gyb.1_Silent_p.L116L|PPP1R12B_uc001gyc.1_Silent_p.L116L	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	890					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			TGAGAGTGCTCTGACTGAAAA	0.473													16	48					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202911291	202911291	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:202911291G>A	uc001gyq.3	-	7	1128	c.861C>T	c.(859-861)ATC>ATT	p.I287I	ADIPOR1_uc010pqd.1_Silent_p.I211I|ADIPOR1_uc001gyr.3_Silent_p.I86I|ADIPOR1_uc001gys.3_Silent_p.I287I	NM_015999	NP_057083	Q96A54	ADR1_HUMAN	adiponectin receptor 1	287	Helical; Name=5; (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity				0			BRCA - Breast invasive adenocarcinoma(75;0.141)			AGCCCTCAGCGATAGTAAAGT	0.537													31	62					0	0	1	0	0
RBBP5	5929	broad.mit.edu	37	1	205065991	205065991	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:205065991G>A	uc001hbu.1	-	12	1345	c.1215C>T	c.(1213-1215)GCC>GCT	p.A405A	RBBP5_uc010prd.1_Silent_p.A440A|RBBP5_uc001hbv.1_Silent_p.A405A|RBBP5_uc010pre.1_Silent_p.A272A	NM_005057	NP_005048	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	405					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			lung(1)	1	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			CTACCTCAGGGGCAATGGGTA	0.478													35	118					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207135711	207135711	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:207135711G>A	uc001hfa.3	-	5	999	c.499C>T	c.(499-501)CGT>TGT	p.R167C	FCAMR_uc001hfb.2_Missense_Mutation_p.R167C|FCAMR_uc009xca.1_Missense_Mutation_p.R167C|FCAMR_uc001hfc.2_Missense_Mutation_p.R142C	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	122	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						ACACGGTCACGATAGCGATGG	0.567													29	70					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207643267	207643267	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:207643267G>A	uc001hfw.2	+	6	1139	c.1045G>A	c.(1045-1047)GTT>ATT	p.V349I	CR2_uc001hfv.2_Missense_Mutation_p.V349I|CR2_uc009xch.2_Missense_Mutation_p.V349I|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	349	Sushi 6.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TACTTCTGCGGTTCAGTGTCC	0.493													37	27					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207890860	207890860	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:207890860C>T	uc001hga.3	+	11	1587	c.1466C>T	c.(1465-1467)ACT>ATT	p.T489I	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	489	Sushi 8.					cytoplasm|extracellular region|membrane					0						CACACAGGAACTCCCCTTGGA	0.428													29	65					0	0	1	0	0
SERTAD4	56256	broad.mit.edu	37	1	210414989	210414989	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:210414989C>T	uc001hhy.2	+	4	557	c.378C>T	c.(376-378)CTC>CTT	p.L126L	SERTAD4_uc009xcw.2_Silent_p.L126L	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	126	SERTA.						protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		AAGTGTACCTCCGAAGATCTG	0.393													30	64					0	0	1	0	0
RD3	343035	broad.mit.edu	37	1	211652529	211652529	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:211652529G>A	uc001him.2	-	3	1601	c.437C>T	c.(436-438)CCC>CTC	p.P146L	RD3_uc001hin.2_RNA|RD3_uc009xda.2_RNA	NM_183059	NP_898882	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	146					response to stimulus|visual perception					ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		GCTGCCGCGGGGCCGCAGGCT	0.687													4	17					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214549624	214549624	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:214549624G>A	uc001hkk.1	-	15	3116	c.2845C>T	c.(2845-2847)CGA>TGA	p.R949*	PTPN14_uc010pty.1_Nonsense_Mutation_p.R850*	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	949	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		AGCTCTACTCGATTCTCCTCA	0.458													50	27					0	0	1	0	0
KCNK2	3776	broad.mit.edu	37	1	215368397	215368397	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:215368397G>T	uc001hkq.2	+	6	1094	c.925G>T	c.(925-927)GAT>TAT	p.D309Y	KCNK2_uc001hko.2_Missense_Mutation_p.D305Y|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.D294Y	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	309	Cytoplasmic (Potential).			DWL -> RLV (in Ref. 3; AAD01203).			outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CATGATTGGAGATTGGCTCCG	0.373													144	87					1.28125e-82	1.30668e-82	1	1	0
USH2A	7399	broad.mit.edu	37	1	215808020	215808020	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:215808020T>A	uc001hku.1	-	70	15465	c.15078A>T	c.(15076-15078)AAA>AAT	p.K5026N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	5026	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATCCCTTCTTTTTCCCAGGAG	0.453										HNSCC(13;0.011)			55	28					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215960037	215960037	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:215960037C>T	uc001hku.1	-	52	10749	c.10362G>A	c.(10360-10362)GGG>GGA	p.G3454G		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3454	Fibronectin type-III 19.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTTTACACTCCCTGTATGAA	0.438										HNSCC(13;0.011)			43	41					0	0	1	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220375673	220375673	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:220375673A>G	uc010puk.1	-	9	920	c.756T>C	c.(754-756)GCT>GCC	p.A252A	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_5'UTR|MIR664_hsa-mir-664|MI0006442_5'Flank|SNORA36B_uc010pul.1_5'Flank	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	252					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		ATTTCTTATAAGCTAATGGTG	0.323													39	42					0	0	1	0	0
DISP1	84976	broad.mit.edu	37	1	223178203	223178203	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:223178203C>T	uc001hnu.1	+	8	3611	c.3464C>T	c.(3463-3465)TCC>TTC	p.S1155F		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1155					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AGTGCCTTTTCCCATGCCTTG	0.473													447	296					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223283800	223283800	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:223283800G>A	uc001hnv.1	-	4	3020	c.2574C>T	c.(2572-2574)TCC>TCT	p.S858S	TLR5_uc001hnw.1_Silent_p.S858S	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	858	Cytoplasmic (Potential).		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		CCTTTGATTAGGAGATGGTTG	0.363													45	45					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223284895	223284895	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:223284895G>A	uc001hnv.1	-	4	1925	c.1479C>T	c.(1477-1479)CTC>CTT	p.L493L	TLR5_uc001hnw.1_Silent_p.L493L	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	493	Extracellular (Potential).|LRR 12.		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		CATCCCAACAGAGCTCAGTTT	0.423													44	28					0	0	1	0	0
NUP133	55746	broad.mit.edu	37	1	229631307	229631307	+	Silent	SNP	A	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:229631307A>C	uc001htn.2	-	8	1073	c.981T>G	c.(979-981)TCT>TCG	p.S327S		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	327					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				AGTTACTTTCAGATCCCTACA	0.194													11	27					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234040833	234040833	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:234040833C>T	uc001hvy.1	+	1	155	c.10C>T	c.(10-12)CGA>TGA	p.R4*		NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	Error:Variant_position_missing_in_Q8IY50_after_alignment					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TATGGGGATTCGAGAGTTTCC	0.711													3	2					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235955367	235955367	+	Nonsense_Mutation	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:235955367G>T	uc001hxj.2	-	12	4350	c.4175C>A	c.(4174-4176)TCA>TAA	p.S1392*	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_Intron|LYST_uc001hxl.1_Nonsense_Mutation_p.S1392*	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1392					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TAGATACTGTGAAGGGCTCAT	0.348									Chediak-Higashi_syndrome				37	57					1.60099e-16	1.62127e-16	1	1	0
HEATR1	55127	broad.mit.edu	37	1	236721628	236721628	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:236721628T>A	uc001hyd.1	-	36	5238	c.5113A>T	c.(5113-5115)AAG>TAG	p.K1705*	HEATR1_uc009xgh.1_Nonsense_Mutation_p.K867*	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1705					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTCTCCTCCTTTCTCTCTGGA	0.522													17	80					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237604755	237604755	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:237604755C>T	uc001hyl.1	+	13	1262	c.1142C>T	c.(1141-1143)TCC>TTC	p.S381F		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	381	Cytoplasmic (By similarity).|MIR 5.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GACGTGAAATCCGTGAGAATG	0.353													63	50					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	240969596	240969596	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:240969596C>T	uc001hyv.2	-	15	1443	c.1113G>A	c.(1111-1113)AAG>AAA	p.K371K	RGS7_uc010pyh.1_Silent_p.K345K|RGS7_uc010pyj.1_Silent_p.K287K|RGS7_uc001hyu.2_Silent_p.K371K|RGS7_uc009xgn.1_Silent_p.K318K|RGS7_uc001hyw.2_Silent_p.K371K|RGS7_uc001hyt.2_Silent_p.K203K	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	371	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TAATAGGCCTCTTTTTCAGGT	0.458													29	91					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243328064	243328064	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:243328064G>A	uc001hzs.2	-	13	3606	c.3198C>T	c.(3196-3198)TCC>TCT	p.S1066S	CEP170_uc001hzt.2_Silent_p.S968S|CEP170_uc001hzu.2_Silent_p.S968S|CEP170_uc001hzv.1_Silent_p.S444S	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1066	Targeting to microtubules.					centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CTTCCAGTTTGGAATGTACAT	0.433													4	48					0	0	1	0	0
OR14A16	284532	broad.mit.edu	37	1	247978897	247978897	+	Missense_Mutation	SNP	C	T	T	rs140410550		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:247978897C>T	uc001idm.1	-	1	135	c.135G>A	c.(133-135)ATG>ATA	p.M45I		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	45	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAGTTGTGATCATGATAATGA	0.393													18	48					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248039759	248039759	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:248039759C>T	uc001ido.2	+	6	1477	c.1429C>T	c.(1429-1431)CCT>TCT	p.P477S	OR2W3_uc001idp.1_Intron	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	477						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TCATTTAGATCCTGCTTCTGA	0.448													33	26					0	0	1	0	0
IL2RA	3559	broad.mit.edu	37	10	6066301	6066301	+	Silent	SNP	C	T	T	rs41290331		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:6066301C>T	uc001iiz.1	-	3	432	c.273G>A	c.(271-273)ACG>ACA	p.T91T	IL2RA_uc009xih.1_Silent_p.T91T|IL2RA_uc001ija.1_Silent_p.T53T	NM_000417	NP_000408	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha chain precursor	91	Extracellular (Potential).				cell proliferation	integral to membrane	interleukin-2 receptor activity			ovary(1)|skin(1)	2					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	TCACTTGTTTCGTTGTGTTCC	0.413													19	10					0	0	1	0	0
CAMK1D	57118	broad.mit.edu	37	10	12856267	12856267	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:12856267G>A	uc001ilo.2	+	7	950	c.715G>A	c.(715-717)GAG>AAG	p.E239K	CAMK1D_uc001iln.2_Missense_Mutation_p.E239K	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	239	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		GGCGGAATATGAGTTTGACTC	0.532													147	44					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13214476	13214476	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:13214476C>T	uc001ima.2	+	4	551	c.450C>T	c.(448-450)TCC>TCT	p.S150S	MCM10_uc001imb.2_Silent_p.S150S|MCM10_uc001imc.2_Silent_p.S150S	NM_182751	NP_877428	Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	150					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TGCAAAAATCCCCTGGTAAGA	0.403													20	16					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15639249	15639249	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:15639249A>G	uc001ioc.1	-	21	2168	c.2168T>C	c.(2167-2169)ATG>ACG	p.M723T	ITGA8_uc010qcb.1_Missense_Mutation_p.M708T	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	723	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						ACACACCACCATCCTGGTTAC	0.458													41	18					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25861613	25861613	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:25861613G>A	uc001isj.2	+	7	1610	c.1550G>A	c.(1549-1551)CGA>CAA	p.R517Q		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	517	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						ACGGCTCAACGAATTCCATAT	0.408													30	8					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28273954	28273954	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:28273954A>T	uc009xky.2	-	4	667	c.569T>A	c.(568-570)ATT>AAT	p.I190N	ARMC4_uc010qdt.1_5'Flank|ARMC4_uc001itz.2_Missense_Mutation_p.I190N	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	190							binding			ovary(4)|skin(2)	6						TCACAATGAAATATGTTTTAG	0.234													5	3					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28343131	28343131	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:28343131C>T	uc001iua.1	-	19	1998	c.1594G>A	c.(1594-1596)GAA>AAA	p.E532K	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Missense_Mutation_p.E532K|MPP7_uc009xla.2_Missense_Mutation_p.E532K	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	532	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						TATTGACTTTCCATTATCTGT	0.308													10	2					0	0	1	0	0
LOC387647	387647	broad.mit.edu	37	10	29710383	29710383	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:29710383C>T	uc001ium.2	+	3		c.1150C>T			LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|LOC387647_uc001iun.2_RNA					Homo sapiens cDNA FLJ31518 fis, clone NT2RI2000064.												0						TCCTGGCCTCCTTGTAAACCC	0.507													10	4					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43292897	43292897	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:43292897C>T	uc001jaj.2	+	11	2373	c.2015C>T	c.(2014-2016)TCC>TTC	p.S672F		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	672					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GAAGACCTTTCCAGAAAGGCA	0.493													44	16					0	0	1	0	0
SYT15	83849	broad.mit.edu	37	10	46963859	46963859	+	Silent	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:46963859C>A	uc001jea.2	-	7	1257	c.1104G>T	c.(1102-1104)GTG>GTT	p.V368V	SYT15_uc001jdz.2_Silent_p.V368V|SYT15_uc001jeb.2_Silent_p.V246V|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	368	Cytoplasmic (Potential).|C2 2.					integral to membrane|plasma membrane					0						CCATGTTCTGCACCACAGTCA	0.607													14	27					0.000308642	0.000309502	1	1	0
CTNNA3	29119	broad.mit.edu	37	10	67829092	67829092	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:67829092G>A	uc009xpn.1	-	15	2256	c.2133C>T	c.(2131-2133)ATC>ATT	p.I711I	CTNNA3_uc001jmw.2_Silent_p.I711I	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	711					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TCTCCATCATGATCATACACA	0.358													40	21					0	0	1	0	0
C10orf55	414236	broad.mit.edu	37	10	75671786	75671786	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:75671786G>A	uc001jvz.1	-	5	454	c.113C>T	c.(112-114)TCG>TTG	p.S38L	PLAU_uc001jwa.2_Intron|PLAU_uc010qkw.1_Intron|PLAU_uc010qkx.1_Intron|PLAU_uc001jwb.2_Intron|PLAU_uc001jwc.2_Intron|PLAU_uc009xrq.1_Intron	NM_001001791	NP_001001791	Q5SWW7	CJ055_HUMAN	hypothetical protein LOC414236	38											0	Prostate(51;0.0112)					GCCTCCTCCCGAATCTCTTCC	0.552													21	3					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79614108	79614108	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:79614108G>A	uc001jzk.2	-	4	627	c.557C>T	c.(556-558)CCT>CTT	p.P186L	DLG5_uc001jzj.2_5'Flank|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	186					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CTCATAGTCAGGATTCAGCCT	0.592													18	6					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97096931	97096931	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:97096931G>A	uc001kkp.2	-	28	3031	c.2986C>T	c.(2986-2988)CCA>TCA	p.P996S	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.P950S|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	996					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CGCCTGCCTGGGACCCCCACA	0.637													16	7					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	97969651	97969651	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:97969651C>T	uc001kls.3	-	9	867	c.689G>A	c.(688-690)GGG>GAG	p.G230E	BLNK_uc001kme.3_Missense_Mutation_p.G125E|BLNK_uc001klt.3_Missense_Mutation_p.G121E|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Missense_Mutation_p.G148E|BLNK_uc001klv.3_Missense_Mutation_p.G125E|BLNK_uc001klw.3_Intron|BLNK_uc001klx.3_Missense_Mutation_p.G207E|BLNK_uc001kly.3_Missense_Mutation_p.G230E|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Missense_Mutation_p.G207E|BLNK_uc001kmb.3_Missense_Mutation_p.G26E|BLNK_uc001kmc.3_Intron|BLNK_uc001kmd.3_Missense_Mutation_p.G148E|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	230	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		TTCCCAGGCCCCACTGTTTCG	0.587													50	15					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98092189	98092189	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:98092189C>T	uc001kmf.2	+	9	1365	c.1195C>T	c.(1195-1197)CAT>TAT	p.H399Y	DNTT_uc001kmg.2_Missense_Mutation_p.H399Y	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	399	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		TGCTTTGGATCATTTTCAAAA	0.433													26	6					0	0	1	0	0
SFXN2	118980	broad.mit.edu	37	10	104488272	104488272	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:104488272C>T	uc001kwb.2	+	4	583	c.417C>T	c.(415-417)TCC>TCT	p.S139S	SFXN2_uc001kwc.2_RNA|SFXN2_uc001kwd.2_RNA	NM_178858	NP_849189	Q96NB2	SFXN2_HUMAN	sideroflexin 2	139					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity				0		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)		ATGCGGCTTCCCCCACATCAG	0.562													18	11					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104679714	104679714	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:104679714G>A	uc001kwm.2	+	1	1601	c.1477G>A	c.(1477-1479)GAC>AAC	p.D493N	CNNM2_uc001kwn.2_Missense_Mutation_p.D493N|CNNM2_uc001kwl.2_Missense_Mutation_p.D493N	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	493	CBS 1.				ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CAATATCGTGGACCTGCTGTT	0.512													40	12					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106982947	106982947	+	Silent	SNP	C	T	T	rs12252190		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:106982947C>T	uc001kyi.1	+	20	3035	c.2808C>T	c.(2806-2808)GTC>GTT	p.V936V	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	936	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCAGTGCAGTCGTGTGGCCCA	0.443													58	22					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107012637	107012637	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:107012637G>A	uc001kyi.1	+	23	3437	c.3210G>A	c.(3208-3210)AGG>AGA	p.R1070R	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1070	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAGAGAGGAGGAAAGGCAATG	0.527													26	6					0	0	1	0	0
C10orf118	55088	broad.mit.edu	37	10	115922811	115922811	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:115922811G>A	uc001lbb.1	-	2	869	c.217C>T	c.(217-219)CAT>TAT	p.H73Y	C10orf118_uc001lbc.1_Missense_Mutation_p.H73Y|C10orf118_uc009xye.1_RNA|C10orf118_uc001lbd.2_Missense_Mutation_p.H73Y|C10orf118_uc001lbe.2_Missense_Mutation_p.H73Y	NM_018017	NP_060487	Q7Z3E2	CJ118_HUMAN	CTCL tumor antigen L14-2	73										ovary(2)	2		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		CCTCCACCATGATCTGGAATA	0.338													31	5					0	0	1	0	0
SFXN4	119559	broad.mit.edu	37	10	120925126	120925126	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:120925126C>T	uc001leb.2	-	1	79	c.34G>A	c.(34-36)GGG>AGG	p.G12R	SFXN4_uc001ldz.2_5'Flank|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	12					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		AGGAGCCGCCCAGGTTGCGTT	0.532													28	2					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124036365	124036365	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:124036365A>G	uc001lgc.1	+	3	329	c.78A>G	c.(76-78)AAA>AAG	p.K26K	BTBD16_uc001lgd.1_Silent_p.K25K	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	26										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				GTTTGCCCAAACAGCCTTTCT	0.507													32	13					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124045742	124045742	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:124045742G>A	uc001lgc.1	+	5	615	c.364G>A	c.(364-366)GAG>AAG	p.E122K	BTBD16_uc001lgd.1_Missense_Mutation_p.E121K	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	122										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CCCCCTGAGGGAGCTGGAGGA	0.597													47	17					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124395581	124395581	+	Missense_Mutation	SNP	G	A	A	rs147966171	by1000genomes	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:124395581G>A	uc001lgk.1	+	50	6342	c.6236G>A	c.(6235-6237)CGA>CAA	p.R2079Q	DMBT1_uc001lgl.1_Missense_Mutation_p.R2069Q|DMBT1_uc001lgm.1_Missense_Mutation_p.R1451Q|DMBT1_uc009xzz.1_Missense_Mutation_p.R2078Q|DMBT1_uc010qtx.1_Missense_Mutation_p.R799Q|DMBT1_uc009yab.1_Missense_Mutation_p.R782Q|DMBT1_uc009yac.1_Missense_Mutation_p.R373Q	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2079	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTCATTGCTCGAGTTTGTGAT	0.517													19	6					0	0	1	0	0
FAM196A	642938	broad.mit.edu	37	10	128974170	128974170	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:128974170C>G	uc001lju.1	-	1	531	c.490G>C	c.(490-492)GCG>CCG	p.A164P	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Missense_Mutation_p.A164P|FAM196A_uc001ljv.1_Missense_Mutation_p.A164P|FAM196A_uc009yap.1_Missense_Mutation_p.A164P	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	164										ovary(2)	2						ACCCGCCCCGCGCCACATGGC	0.552													26	11					0	0	1	0	0
SYCE1	93426	broad.mit.edu	37	10	135368917	135368917	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr10:135368917C>T	uc001lno.2	-	12	961	c.856G>A	c.(856-858)GGA>AGA	p.G286R	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Missense_Mutation_p.G158R|SYCE1_uc009ybn.2_Missense_Mutation_p.G286R|SYCE1_uc001lnn.2_Missense_Mutation_p.G250R	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	286	Gln-rich.|Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		ACTTGCATTCCATGCTTTTCC	0.398													40	18					0	0	1	0	0
LRRC56	115399	broad.mit.edu	37	11	552635	552635	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:552635G>A	uc010qvz.1	+	13	1753	c.1248G>A	c.(1246-1248)AGG>AGA	p.R416R		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	416										skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCCACGGAGGGTCCCTGAAG	0.687													10	9					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	609185	609185	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:609185C>T	uc001lqe.2	+	14	3860	c.3729C>T	c.(3727-3729)CCC>CCT	p.P1243P	PHRF1_uc010qwc.1_Silent_p.P1242P|PHRF1_uc010qwd.1_Silent_p.P1241P|PHRF1_uc010qwe.1_Silent_p.P1239P|PHRF1_uc009ybz.1_Silent_p.P1033P|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1243							RNA polymerase binding|zinc ion binding				0						TGCAGGCTCCCCCTGTCCTGG	0.652													19	46					0	0	1	0	0
TH	7054	broad.mit.edu	37	11	2191038	2191038	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:2191038C>T	uc001lvq.2	-	3	266	c.247G>A	c.(247-249)GCG>ACG	p.A83T	TH_uc001lvp.2_Missense_Mutation_p.A79T|TH_uc001lvr.2_Missense_Mutation_p.A52T|TH_uc010qxj.1_Missense_Mutation_p.A56T|TH_uc001lvs.2_Missense_Mutation_p.A52T|TH_uc001lvt.2_Missense_Mutation_p.A56T|TH_uc009ydh.1_5'Flank	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	83					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	GCTGCCACCGCCGCCTCCCGC	0.701													7	10					0	0	1	0	0
OR52K2	119774	broad.mit.edu	37	11	4471283	4471283	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:4471283G>T	uc001lyz.1	+	1	714	c.714G>T	c.(712-714)AAG>AAT	p.K238N		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	238	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCGCTACAAGGCATTTGGGA	0.493													66	87					4.45325e-31	4.5352e-31	1	1	0
OR52R1	119695	broad.mit.edu	37	11	4825176	4825176	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:4825176G>A	uc010qym.1	-	1	672	c.672C>T	c.(670-672)ATC>ATT	p.I224I		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCCCCAGTTTGATCACGACCG	0.587													21	36					0	0	1	0	0
OR51F2	119694	broad.mit.edu	37	11	4843021	4843021	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:4843021C>T	uc010qyn.1	+	1	406	c.406C>T	c.(406-408)CGT>TGT	p.R136C		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCCTTTGATCGTTTTGTGGC	0.463													75	82					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4869964	4869964	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:4869964G>A	uc010qyo.1	-	1	475	c.475C>T	c.(475-477)CGA>TGA	p.R159*		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCAGGCATCGAAAAGAAATG	0.542													48	54					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4929031	4929031	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:4929031G>A	uc010qyq.1	+	1	432	c.432G>A	c.(430-432)ATG>ATA	p.M144I		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTGCTAAAATGGGACTTATTT	0.368													28	46					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936570	4936570	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:4936570G>A	uc001lzr.1	-	1	324	c.324C>T	c.(322-324)TTC>TTT	p.F108F		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCAGTGAATGAAAAAGAGCT	0.507													13	14					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5013338	5013338	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5013338G>A	uc001lzv.2	+	5	758	c.740G>A	c.(739-741)AGG>AAG	p.R247K		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	247					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		GATATCCAAAGGATCCAGCAT	0.453													17	16					0	0	1	0	0
OR52A4	390053	broad.mit.edu	37	11	5142675	5142676	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5142675_5142676CC>TT	uc001lzz.1	-	1	133_134	c.133_134GG>AA	c.(133-135)GGA>AAA	p.G45K	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TAGAGAATTTCCAATCAGAGCA	0.436													32	51					0	0	1	0	0
HBB	3043	broad.mit.edu	37	11	5247894	5247894	+	Silent	SNP	C	T	T	rs35452098		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5247894C>T	uc001mae.1	-	2	278	c.228G>A	c.(226-228)CTG>CTA	p.L76L		NM_000518	NP_000509	P68871	HBB_HUMAN	beta globin	76			L -> R (in Pasadena; O(2) affinity up; unstable).|L -> P (in Atlanta; unstable).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	CCAGGTGAGCCAGGCCATCAC	0.542									Sickle_Cell_Trait				42	39					0	0	1	0	0
OR52D1	390066	broad.mit.edu	37	11	5510223	5510223	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5510223C>T	uc010qzg.1	+	1	287	c.287C>T	c.(286-288)TCC>TTC	p.S96F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGTGAGATTTCCTTTGGTGGA	0.498													21	34					0	0	1	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529600	5529600	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5529600G>A	uc001may.1	-	2	1275	c.1189C>T	c.(1189-1191)CCC>TCC	p.P397S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	397										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GACTCCTCGGGGAGAGGCTGG	0.572													58	75					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5536481	5536481	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5536481C>A	uc001maz.3	-	1	1476	c.1191G>T	c.(1189-1191)AAG>AAT	p.K397N	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	397										large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		CAGTGGCATCCTTGTATTCTT	0.522													40	46					1.07121e-22	1.08784e-22	1	1	0
TRIM22	10346	broad.mit.edu	37	11	5730793	5730793	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5730793G>A	uc001mbr.2	+	8	1689	c.1412G>A	c.(1411-1413)GGA>GAA	p.G471E	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.2_Missense_Mutation_p.G467E|TRIM22_uc010qzm.1_Missense_Mutation_p.G299E|TRIM22_uc009yeu.2_Missense_Mutation_p.G282E|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	471	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		AAGTTCTCTGGATGTCGCTTT	0.488													70	89					0	0	1	0	0
OR52N5	390075	broad.mit.edu	37	11	5799163	5799163	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5799163C>T	uc010qzn.1	-	1	702	c.702G>A	c.(700-702)GCG>GCA	p.A234A	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		AGAGGCTGATCGCTGCCTTGA	0.438													26	32					0	0	1	0	0
OR52N5	390075	broad.mit.edu	37	11	5799718	5799718	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5799718C>T	uc010qzn.1	-	1	147	c.147G>A	c.(145-147)GGG>GGA	p.G49G	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	49	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		GACCAAGATTCCCCACAAGGA	0.423													50	68					0	0	1	0	0
OR52E8	390079	broad.mit.edu	37	11	5878510	5878510	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5878510G>A	uc010qzr.1	-	1	423	c.423C>T	c.(421-423)ATC>ATT	p.I141I	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	141	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCTGGTGAGGATCATGGTGT	0.498													78	107					0	0	1	0	0
OR52E8	390079	broad.mit.edu	37	11	5878925	5878925	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5878925C>T	uc010qzr.1	-	1	8	c.8G>A	c.(7-9)GGA>GAA	p.G3E	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGACATTCTTCCTGCCATATA	0.423													36	50					0	0	1	0	0
OR56A3	390083	broad.mit.edu	37	11	5968801	5968801	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:5968801C>T	uc010qzt.1	+	1	225	c.225C>T	c.(223-225)ATC>ATT	p.I75I		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCTGGACATCGTGCTCTGCC	0.592													55	77					0	0	1	0	0
CCKBR	887	broad.mit.edu	37	11	6281242	6281242	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:6281242C>T	uc001mcp.2	+	1	277	c.84C>T	c.(82-84)CTC>CTT	p.L28L	CCKBR_uc001mcq.2_5'UTR|CCKBR_uc001mcr.2_Silent_p.L28L|CCKBR_uc001mcs.2_Silent_p.L28L	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	28	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GGGCGCCTCTCCTCAACAGCA	0.721													6	13					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7063707	7063707	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:7063707C>T	uc001mfb.1	+	4	773	c.450C>T	c.(448-450)TTC>TTT	p.F150F		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	150					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CTGAAGATTTCCATCATGGAA	0.418													27	30					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7091574	7091574	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:7091574C>T	uc001mfb.1	+	11	3356	c.3033C>T	c.(3031-3033)ATC>ATT	p.I1011I		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	1011					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CTGCTCTTATCTGCAACAAAA	0.348													17	31					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7335157	7335157	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:7335157C>T	uc001mfe.2	+	3	1266	c.1029C>T	c.(1027-1029)ATC>ATT	p.I343I	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	343	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GGAAGGATATCGAATATGTCA	0.453													38	69					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7981529	7981529	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:7981529C>T	uc001mfv.1	-	2	1647	c.1630G>A	c.(1630-1632)GAT>AAT	p.D544N		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	544							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGCTTCAGATCCTGCGCTAAA	0.408													19	29					0	0	1	0	0
C11orf16	56673	broad.mit.edu	37	11	8947545	8947545	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:8947545C>T	uc001mhb.3	-	5	793	c.669G>A	c.(667-669)GAG>GAA	p.E223E	C11orf16_uc001mhc.3_Silent_p.E223E	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	223								p.E223V(1)		upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		TGTGCAGCCTCTCCACAGCCT	0.557													46	57					0	0	1	0	0
DENND5A	23258	broad.mit.edu	37	11	9187423	9187423	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:9187423C>T	uc001mhl.2	-	11	2498	c.2243G>A	c.(2242-2244)TGG>TAG	p.W748*	DENND5A_uc001mhk.2_Nonsense_Mutation_p.W91*|DENND5A_uc010rbw.1_Nonsense_Mutation_p.W748*|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	748										liver(1)	1						TACAAACTTCCAATTGGTCTG	0.488													31	47					0	0	1	0	0
BTBD10	84280	broad.mit.edu	37	11	13427337	13427337	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:13427337A>G	uc001mkz.2	-	7	1132	c.875T>C	c.(874-876)ATG>ACG	p.M292T	BTBD10_uc010rcl.1_Missense_Mutation_p.M300T|BTBD10_uc001mla.2_Missense_Mutation_p.M276T|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Missense_Mutation_p.M244T|BTBD10_uc010rcn.1_Missense_Mutation_p.M261T|BTBD10_uc009ygo.2_Missense_Mutation_p.M244T	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	292						nucleus					0				Epithelial(150;0.0214)		AGGGAGGATCATTTCTTCCAG	0.398													31	47					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17139104	17139104	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:17139104C>T	uc001mmq.3	-	18	3216	c.3150G>A	c.(3148-3150)ACG>ACA	p.T1050T	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Silent_p.T670T|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1050					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	GTACAAGTTTCGTCTGTTTTA	0.418													22	52					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955962	18955962	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:18955962C>T	uc001mpg.2	-	1	588	c.370G>A	c.(370-372)GTC>ATC	p.V124I		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	124	Cytoplasmic (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						GGCCACAGGACGGACAGGCAG	0.602													28	76					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20077463	20077463	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:20077463C>T	uc010rdm.1	+	20	5221	c.4860C>T	c.(4858-4860)ACC>ACT	p.T1620T	NAV2_uc001mpp.2_Silent_p.T1533T|NAV2_uc001mpr.3_Silent_p.T1597T|NAV2_uc001mpt.2_Silent_p.T646T|NAV2_uc009yhx.2_Silent_p.T661T|NAV2_uc009yhy.1_Silent_p.T559T|NAV2_uc009yhz.2_Silent_p.T242T|NAV2_uc001mpu.2_Silent_p.T35T	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1620	Ser-rich.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						AGAGCAGAACCATGAGCCGTT	0.423													19	25					0	0	1	0	0
MPPED2	744	broad.mit.edu	37	11	30435775	30435775	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:30435775C>T	uc001msr.2	-	5	886	c.766G>A	c.(766-768)GGT>AGT	p.G256S	MPPED2_uc001msq.3_Missense_Mutation_p.V256I|MPPED2_uc009yji.2_Missense_Mutation_p.G130S	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	256					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						CTGTTCTTACCTTCATGGATT	0.428													19	22					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32663598	32663598	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:32663598C>T	uc001mtv.2	-	13	1014	c.970G>A	c.(970-972)GAG>AAG	p.E324K	CCDC73_uc001mtw.1_Missense_Mutation_p.E314K	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	324	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TTTACCTTCTCCCTTTGCAGC	0.284													3	14					0	0	1	0	0
RAG2	5897	broad.mit.edu	37	11	36614213	36614213	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:36614213C>T	uc001mwv.3	-	2	1694	c.1506G>A	c.(1504-1506)ATG>ATA	p.M502I	RAG1_uc001mwt.2_Intron|C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	502					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				GGAGGGATTTCATTGGAGGCT	0.408									Familial_Hemophagocytic_Lymphohistiocytosis				32	34					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137107	40137107	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:40137107G>A	uc001mxa.1	-	2	2700	c.736C>T	c.(736-738)CAA>TAA	p.Q246*	LRRC4C_uc001mxc.1_Nonsense_Mutation_p.Q242*|LRRC4C_uc001mxd.1_Nonsense_Mutation_p.Q242*|LRRC4C_uc001mxb.1_Nonsense_Mutation_p.Q242*	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	246	LRR 8.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CACAGTTTTTGAAGGTGCATC	0.453													21	25					0	0	1	0	0
CHRM4	1132	broad.mit.edu	37	11	46406877	46406877	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:46406877G>A	uc001nct.1	-	1	1231	c.1231C>T	c.(1231-1233)CTC>TTC	p.L411F		NM_000741	NP_000732	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	411	Helical; Name=6; (By similarity).				cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity				0				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	GTCCAGGTGAGGATGAAGGCT	0.597													6	15					0	0	1	0	0
C1QTNF4	114900	broad.mit.edu	37	11	47612180	47612180	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:47612180G>A	uc001ngc.2	-	2	450	c.183C>T	c.(181-183)TTC>TTT	p.F61F		NM_031909	NP_114115	Q9BXJ3	C1QT4_HUMAN	C1q and tumor necrosis factor related protein 4	61	C1q 1.					extracellular region					0						TGGCCACATCGAAGTCGCCCC	0.672													8	9					0	0	1	0	0
OR4B1	119765	broad.mit.edu	37	11	48238555	48238555	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:48238555C>T	uc010rhs.1	+	1	194	c.194C>T	c.(193-195)TCC>TTC	p.S65F		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						AGCTGCCTGTCCTTGGTGGAG	0.488													41	59					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347200	48347200	+	Silent	SNP	C	T	T	rs141730559		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:48347200C>T	uc010rhv.1	+	1	708	c.708C>T	c.(706-708)TTC>TTT	p.F236F		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGTTGAACTTCCTCATGCTGG	0.522													19	29					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55135613	55135613	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:55135613C>T	uc010rif.1	+	1	254	c.254C>T	c.(253-255)TCC>TTC	p.S85F		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	85	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCCCTGGGTTCCCCCATGTAC	0.408													40	41					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55340378	55340378	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:55340378C>T	uc010rih.1	+	1	775	c.775C>T	c.(775-777)CTT>TTT	p.L259F		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GTACACATGCCTTGCAACCGT	0.403													15	28					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433091	55433091	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:55433091G>A	uc001nht.3	+	3	714	c.449G>A	c.(448-450)GGA>GAA	p.G150E	OR4C6_uc010rik.1_Missense_Mutation_p.G150E	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TGGGTGGGGGGATTTATGCAC	0.468													35	47					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587654	55587654	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:55587654C>T	uc010rin.1	+	1	549	c.549C>T	c.(547-549)TCC>TCT	p.S183S		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GTGAGTTCTCCTCACTACTCT	0.423													38	56					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55905009	55905009	+	Silent	SNP	G	A	A	rs144645378		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:55905009G>A	uc010riz.1	-	1	186	c.186C>T	c.(184-186)TTC>TTT	p.F62F		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F62F(1)		skin(2)	2	Esophageal squamous(21;0.00693)					GATGTCTCAGGAAAAAGTACA	0.438													49	79					0	0	1	0	0
OR5J2	282775	broad.mit.edu	37	11	55944407	55944407	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:55944407G>A	uc010rjb.1	+	1	314	c.314G>A	c.(313-315)GGA>GAA	p.G105E		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					TTGTGTTTCGGAGTGTTCATC	0.463													33	50					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56057639	56057639	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:56057639G>A	uc010rje.1	-	1	900	c.900C>T	c.(898-900)CTC>CTT	p.L300L		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					TGACTCTAATGAGAGCATTTT	0.353													37	60					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57983038	57983038	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:57983038C>T	uc010rkc.1	+	1	822	c.822C>T	c.(820-822)TTC>TTT	p.F274F		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	274	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				TGTACTTTTTCCCCTCCTCCA	0.473													41	42					0	0	1	0	0
OR5B3	441608	broad.mit.edu	37	11	58170558	58170558	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:58170558C>T	uc010rkf.1	-	1	325	c.325G>A	c.(325-327)GAA>AAA	p.E109K		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGGTAATTTTCCACAGTGGCA	0.458													36	40					0	0	1	0	0
OR5B2	390190	broad.mit.edu	37	11	58190358	58190358	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:58190358T>C	uc010rkg.1	-	1	377	c.377A>G	c.(376-378)AAA>AGA	p.K126R		NM_001005566	NP_001005566	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GTGTAGGGGTTTGCACACTGC	0.512													18	36					0	0	1	0	0
OR5B21	219968	broad.mit.edu	37	11	58274928	58274928	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:58274928G>A	uc010rki.1	-	1	651	c.651C>T	c.(649-651)TTC>TTT	p.F217F		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGATGCATATGAAGAAGTAAG	0.473													17	22					0	0	1	0	0
OR4D10	390197	broad.mit.edu	37	11	59245168	59245168	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:59245168G>A	uc001nnz.1	+	1	266	c.266G>A	c.(265-267)AGA>AAA	p.R89K		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CTGTCTGAAAGAAAGACCATC	0.433													42	46					0	0	1	0	0
MS4A2	2206	broad.mit.edu	37	11	59857202	59857202	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:59857202G>A	uc001nop.2	+	2	196	c.94G>A	c.(94-96)GAA>AAA	p.E32K	MS4A2_uc009ymu.2_Missense_Mutation_p.E32K	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	32	Cytoplasmic (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	ATCTCCCCAGGAAGTATCTTC	0.453													25	30					0	0	1	0	0
MS4A10	341116	broad.mit.edu	37	11	60558500	60558500	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:60558500C>T	uc001npz.1	+	3	333	c.237C>T	c.(235-237)GCC>GCT	p.A79A		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	79	Helical; (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2						GCTACCTGGCCTCTATAGTCA	0.582													43	71					0	0	1	0	0
MTA2	9219	broad.mit.edu	37	11	62363555	62363555	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:62363555G>A	uc001ntq.1	-	12	1422	c.1041C>T	c.(1039-1041)ATC>ATT	p.I347I	MTA2_uc010rlx.1_Silent_p.I174I	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	347					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CCACAGAAATGATCTGGTTAG	0.488													14	24					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62763521	62763521	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:62763521C>T	uc001nwo.2	-	6	1001	c.865G>A	c.(865-867)GGA>AGA	p.G289R	SLC22A8_uc001nwn.1_Missense_Mutation_p.G80R|SLC22A8_uc001nwp.2_Missense_Mutation_p.G289R|SLC22A8_uc009yom.2_Missense_Mutation_p.G166R|SLC22A8_uc010rmm.1_Missense_Mutation_p.G198R|SLC22A8_uc009yon.2_Missense_Mutation_p.G289R	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	289	Cytoplasmic (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						AGCCTTTCTCCCTCTTCCTTC	0.582													30	42					0	0	1	0	0
C11orf20	25858	broad.mit.edu	37	11	64070988	64070988	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:64070988G>A	uc009ypm.2	+	3	407	c.387G>A	c.(385-387)GCG>GCA	p.A129A	KCNK4_uc001nzm.3_RNA|ESRRA_uc001nzq.1_5'Flank|ESRRA_uc001nzr.1_5'Flank|ESRRA_uc001nzs.1_5'Flank	NM_001039496	NP_001034585	Q9NTU4	CK020_HUMAN	hypothetical protein LOC25858	129					cell differentiation|spermatogenesis	cytoplasm					0						TCAATATTGCGAAGCACATGC	0.552													14	12					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64502690	64502690	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:64502690G>A	uc009ypu.2	-	12	1533	c.1306C>T	c.(1306-1308)CGG>TGG	p.R436W	RASGRP2_uc001oat.2_Missense_Mutation_p.R338W|RASGRP2_uc001oau.2_Missense_Mutation_p.R291W|RASGRP2_uc009ypv.2_Missense_Mutation_p.R436W|RASGRP2_uc009ypw.2_Missense_Mutation_p.R436W	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	436	EF-hand 1.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						TCAAAGTTCCGGAACACAGAC	0.572													10	23					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65266120	65266120	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:65266120C>T	uc010roh.1	+	1		c.888C>T				NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						AAGTAAAGCCCTGAACTATCA	0.458													18	50					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67261496	67261497	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:67261496_67261497GG>AA	uc001olx.2	-	19	3093_3094	c.2904_2905CC>TT	c.(2902-2907)ATCCAC>ATTTAC	p.H969Y	PITPNM1_uc001olw.2_Missense_Mutation_p.H251Y|PITPNM1_uc001oly.2_Missense_Mutation_p.H969Y|PITPNM1_uc001olz.2_Missense_Mutation_p.H968Y	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	969					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						GTGCCAAAGTGGATCCACTTGC	0.639													16	21					0	0	1	0	0
CLPB	81570	broad.mit.edu	37	11	72005444	72005444	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:72005444G>A	uc001osj.2	-	15	1745	c.1695C>T	c.(1693-1695)ATC>ATT	p.I565I	CLPB_uc010rqx.1_Silent_p.I520I|CLPB_uc010rqy.1_Silent_p.I506I|CLPB_uc001osk.2_Silent_p.I535I|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Silent_p.I364I|CLPB_uc001osi.2_Silent_p.I173I	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	565					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						GGAAGTAGACGATCTCATTGA	0.557													120	192					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73073519	73073519	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:73073519C>T	uc001otu.2	+	14	4757	c.4736C>T	c.(4735-4737)CCG>CTG	p.P1579L		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1579					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GAGACGGCACCGGAGCCCGCC	0.706													10	19					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76873905	76873905	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:76873905G>A	uc001oyb.2	+	14	1833	c.1561G>A	c.(1561-1563)GAC>AAC	p.D521N	MYO7A_uc010rsl.1_Missense_Mutation_p.D521N|MYO7A_uc010rsm.1_Missense_Mutation_p.D510N|MYO7A_uc001oyc.2_Missense_Mutation_p.D521N	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	521	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCAGGGCACAGACACCACCAT	0.582													45	45					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76886426	76886426	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:76886426C>T	uc001oyb.2	+	18	2375	c.2103C>T	c.(2101-2103)CTC>CTT	p.L701L	MYO7A_uc010rsl.1_Silent_p.L701L|MYO7A_uc010rsm.1_Silent_p.L690L|MYO7A_uc001oyc.2_Silent_p.L701L|MYO7A_uc001oyd.2_Silent_p.L41L	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	701	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						AGGGCGACCTCCGCGGGACTT	0.443													30	58					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77451871	77451871	+	Silent	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:77451871G>T	uc001oyn.2	-	4	603	c.483C>A	c.(481-483)CTC>CTA	p.L161L		NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	161					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			ACCAGTACATGAGGCCATCTT	0.398													18	37					1.99824e-07	2.01081e-07	1	1	0
GAB2	9846	broad.mit.edu	37	11	77934491	77934491	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:77934491G>A	uc001ozh.2	-	6	1534	c.1534C>T	c.(1534-1536)CCT>TCT	p.P512S	GAB2_uc001ozg.2_Missense_Mutation_p.P474S	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	512	SH3-binding.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			CGGTTGACAGGGGGTGGCTGA	0.547													53	72					0	0	1	0	0
ODZ4	26011	broad.mit.edu	37	11	78380298	78380298	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:78380298C>T	uc001ozl.3	-	32	7555	c.7092G>A	c.(7090-7092)GGG>GGA	p.G2364G	ODZ4_uc001ozk.3_Silent_p.G589G|ODZ4_uc009yvb.1_Silent_p.G948G	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2364	Extracellular (Potential).|YD 23.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CAAGAGGGGTCCCGATGTTGT	0.483													25	31					0	0	1	0	0
ODZ4	26011	broad.mit.edu	37	11	78516338	78516338	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:78516338G>A	uc001ozl.3	-	15	2641	c.2178C>T	c.(2176-2178)ATC>ATT	p.I726I		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	726	Extracellular (Potential).|EGF-like 6.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TGCATTTACCGATAGAACAGT	0.552													5	5					0	0	1	0	0
NAALAD2	10003	broad.mit.edu	37	11	89896481	89896481	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:89896481G>A	uc001pdf.3	+	10	1188	c.1079G>A	c.(1078-1080)AGG>AAG	p.R360K	NAALAD2_uc009yvx.2_Missense_Mutation_p.R327K|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pde.2_Missense_Mutation_p.R267K	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	360	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TTTCCAGACAGGTATGTTATT	0.368													48	76					0	0	1	0	0
NAALAD2	10003	broad.mit.edu	37	11	89896702	89896702	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:89896702G>A	uc001pdf.3	+	11	1305	c.1196_splice	c.e11-1	p.G399_splice	NAALAD2_uc009yvx.2_Splice_Site_p.G366_splice|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pde.2_Splice_Site_p.G306_splice	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2						proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				AATTCTTACAGGCTGGAGACC	0.388													19	24					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93778875	93778875	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:93778875G>A	uc001pep.2	+	2	364	c.207G>A	c.(205-207)AGG>AGA	p.R69R		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	69	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GGCCCAACAGGATAGGCAGTA	0.423													4	8					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100912728	100912728	+	Missense_Mutation	SNP	G	A	A	rs2020880		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:100912728G>A	uc001pgh.2	-	7	3337	c.2594C>T	c.(2593-2595)TCG>TTG	p.S865L	PGR_uc001pgg.2_Missense_Mutation_p.S246L|PGR_uc001pgi.2_Missense_Mutation_p.S763L|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	865	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CTGTGAGCTCGACACAACTCC	0.388													9	22					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101375292	101375292	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:101375292G>A	uc001pgk.3	-	2	833	c.408C>T	c.(406-408)GCC>GCT	p.A136A	TRPC6_uc009ywy.2_Silent_p.A136A|TRPC6_uc009ywz.1_Silent_p.A136A	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	136	Cytoplasmic (Potential).|ANK 2.				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CCAACTGTAGGGCATTCTGGC	0.453													37	27					0	0	1	0	0
MMP27	64066	broad.mit.edu	37	11	102564738	102564738	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:102564738G>A	uc001phd.1	-	8	1115	c.1092C>T	c.(1090-1092)ATC>ATT	p.I364I		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	364	Hemopexin-like 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		CTAATGTATGGATGGATTTGG	0.408													34	34					0	0	1	0	0
MMP1	4312	broad.mit.edu	37	11	102661252	102661252	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:102661252C>T	uc001phi.2	-	10	1444	c.1301G>A	c.(1300-1302)GGA>GAA	p.G434E	uc001phh.1_Intron|MMP1_uc010ruv.1_Missense_Mutation_p.G368E	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	434	Hemopexin-like 4.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		ATAGAAAAATCCTAGAAACAA	0.323													6	6					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110477360	110477360	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:110477360C>T	uc001pkz.1	-	10	1174	c.889G>A	c.(889-891)GAA>AAA	p.E297K	ARHGAP20_uc001pky.1_Missense_Mutation_p.E274K|ARHGAP20_uc009yyb.1_Missense_Mutation_p.E261K|ARHGAP20_uc001pla.1_Missense_Mutation_p.E261K	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	297					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GGGAGCTGTTCCATAAGGAAG	0.527													70	23					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110485297	110485297	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:110485297C>T	uc001pkz.1	-	7	903	c.618G>A	c.(616-618)GGG>GGA	p.G206G	ARHGAP20_uc001pky.1_Silent_p.G183G|ARHGAP20_uc009yyb.1_Silent_p.G170G|ARHGAP20_uc001pla.1_Silent_p.G170G	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	206	Ras-associating.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		AGGCACAATTCCCAATGTCCT	0.428													18	7					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117280472	117280472	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:117280472C>T	uc001prc.2	+	30	4034	c.3887C>T	c.(3886-3888)TCC>TTC	p.S1296F	CEP164_uc001prb.2_Missense_Mutation_p.S1291F|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_Missense_Mutation_p.S721F	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1296					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		CTCCTCGCCTCCATGCCAGCC	0.657													50	19					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117376437	117376437	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:117376437C>T	uc001prh.1	-	9	1976	c.1974G>A	c.(1972-1974)CTG>CTA	p.L658L		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	598	Extracellular (Potential).|Ig-like C2-type 7.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGGCTGGATCAGAGGGGGCA	0.647													12	5					0	0	1	0	0
MLL	4297	broad.mit.edu	37	11	118375435	118375435	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:118375435C>T	uc001pta.2	+	27	8842	c.8819C>T	c.(8818-8820)ACT>ATT	p.T2940I	MLL_uc001ptb.2_Missense_Mutation_p.T2943I	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2940					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CGGAGTCCCACTGTCCCCAGC	0.493			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								38	11					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008109	120008109	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:120008109G>A	uc001pwz.2	-	1	755	c.631C>T	c.(631-633)CAC>TAC	p.H211Y	TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	211					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		AGCAGCTGGTGGTCTCGGAAG	0.642													20	5					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121403206	121403206	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:121403206G>A	uc001pxx.2	+	12	1710	c.1630G>A	c.(1630-1632)GAC>AAC	p.D544N		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	544	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CACATGGGGAGACCACGGCGG	0.488													10	9					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123900541	123900541	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:123900541T>A	uc001pzp.1	+	1	212	c.212T>A	c.(211-213)TTC>TAC	p.F71Y		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GACATGTGGTTCTCCACTGTC	0.522													39	13					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124179772	124179772	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:124179772C>T	uc010sag.1	-	1	891	c.891G>A	c.(889-891)GTG>GTA	p.V297V		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		ATGCTTTCTTCACATCCTTAT	0.408													18	5					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180115	124180115	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:124180115G>A	uc010sag.1	-	1	548	c.548C>T	c.(547-549)CCC>CTC	p.P183L		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		ATTGAGGAGGGGAAGAACATC	0.458													14	5					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124252337	124252337	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:124252337C>T	uc010sai.1	-	1	903	c.903G>A	c.(901-903)AGG>AGA	p.R301R		NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TCAGAGCTTTCCTCAGTGCAA	0.348													22	3					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294385	124294385	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:124294385G>A	uc010sak.1	-	1	383	c.383C>T	c.(382-384)CCC>CTC	p.P128L		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GTAGAGCAGGGGGTTGCAGAT	0.493													22	5					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	330160	330160	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:330160G>A	uc001qic.1	-	15	1816	c.1763C>T	c.(1762-1764)CCC>CTC	p.P588L	SLC6A13_uc009zdj.1_Missense_Mutation_p.P578L|SLC6A13_uc010sdl.1_Missense_Mutation_p.P496L	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	588	Cytoplasmic (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TGAGGTCCTGGGGGTGGCGGG	0.657													11	20					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	333188	333189	+	Missense_Mutation	DNP	GG	AC	AC			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:333188_333189GG>AC	uc001qic.1	-	11	1333_1334	c.1280_1281CC>GT	c.(1279-1281)TCC>TGT	p.S427C	SLC6A13_uc009zdj.1_Missense_Mutation_p.S417C|SLC6A13_uc010sdl.1_Missense_Mutation_p.S335C	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	427	Helical; Name=9; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CCACAAGGAAGGAGACGACAGA	0.584													10	24					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	416919	416919	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:416919G>A	uc001qif.1	-	23	3994	c.3631C>T	c.(3631-3633)CTT>TTT	p.L1211F	KDM5A_uc001qie.1_Missense_Mutation_p.L1211F	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1211	PHD-type 2.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						AGAGGGCAAAGGAATTTTACT	0.473			T 	NUP98	AML								25	30					0	0	1	0	0
C12orf4	57102	broad.mit.edu	37	12	4609424	4609424	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:4609424C>T	uc001qms.2	-	11	1408	c.1320G>A	c.(1318-1320)TCG>TCA	p.S440S	C12orf4_uc001qmt.2_Silent_p.S440S	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	440											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		TGATGTTTCCCGATTTCACAT	0.408													20	27					0	0	1	0	0
AKAP3	10566	broad.mit.edu	37	12	4736815	4736815	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:4736815C>T	uc001qnb.3	-	4	1482	c.1253G>A	c.(1252-1254)CGA>CAA	p.R418Q		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	418					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						GTTCACATTTCGGTTTTTAGG	0.423													41	51					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4872467	4872467	+	Missense_Mutation	SNP	G	A	A	rs36007275		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:4872467G>A	uc001qne.1	+	8	1500	c.1408G>A	c.(1408-1410)GAA>AAA	p.E470K		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	470	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						GGCACTCCGGGAAAAACTGAA	0.388													17	26					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4920690	4920690	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:4920690G>A	uc001qng.2	+	1	2349	c.1483G>A	c.(1483-1485)GGA>AGA	p.G495R		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	495						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						AACTGACAACGGACTTGGCAA	0.592										HNSCC(72;0.22)			24	37					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5848555	5848555	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:5848555G>A	uc001qnm.2	-	13	1422	c.1350C>T	c.(1348-1350)TTC>TTT	p.F450F		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	455	Helical; (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						AGTTTTCCAGGAACATGGTAG	0.438													3	4					0	0	1	0	0
GAPDH	2597	broad.mit.edu	37	12	6646283	6646283	+	Missense_Mutation	SNP	G	A	A	rs11549340		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:6646283G>A	uc001qop.1	+	6	446	c.344G>A	c.(343-345)GGA>GAA	p.G115E	GAPDH_uc009zep.1_Missense_Mutation_p.G73E|GAPDH_uc001qoq.1_Missense_Mutation_p.G40E|GAPDH_uc001qor.1_Missense_Mutation_p.G74E|GAPDH_uc001qos.1_Missense_Mutation_p.G115E|GAPDH_uc001qot.1_Missense_Mutation_p.G115E|GAPDH_uc001qou.1_Missense_Mutation_p.G74E|GAPDH_uc001qov.1_Missense_Mutation_p.G73E|GAPDH_uc001qow.1_Missense_Mutation_p.G68E|GAPDH_uc001qox.1_5'Flank	NM_002046	NP_002037	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	115	Interaction with WARS.				gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding				0					NADH(DB00157)	TTGCAGGGGGGAGCCAAAAGG	0.577													13	21					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6709724	6709724	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:6709724G>A	uc001qpo.2	-	8	1203	c.1039C>T	c.(1039-1041)CGA>TGA	p.R347*	CHD4_uc001qpn.2_Nonsense_Mutation_p.R340*|CHD4_uc001qpp.2_Nonsense_Mutation_p.R344*	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	347					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TTAGTGGTTCGGAGTTTCTTG	0.448													36	41					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7640594	7640594	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:7640594C>T	uc001qsz.3	-	7	1638	c.1510G>A	c.(1510-1512)GAT>AAT	p.D504N	CD163_uc001qta.3_Missense_Mutation_p.D504N|CD163_uc009zfw.2_Missense_Mutation_p.D504N	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	504	SRCR 5.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						AAGTCCGAATCACAGATGGAG	0.527													14	15					0	0	1	0	0
DPPA3	359787	broad.mit.edu	37	12	7864227	7864227	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:7864227G>A	uc001qtf.2	+	1	139	c.61G>A	c.(61-63)GAA>AAA	p.E21K		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	21						cytoplasm|nucleus					0				Kidney(36;0.0887)		GCTCACCGAAGAAAATTCCCG	0.478													10	17					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13715852	13715852	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:13715852G>A	uc001rbt.2	-	13	4499	c.4320C>T	c.(4318-4320)GCC>GCT	p.A1440A		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1440	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCTGGAAACGGGCTGGCACGG	0.612													36	32					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716965	13716965	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:13716965G>A	uc001rbt.2	-	13	3386	c.3207C>T	c.(3205-3207)ACC>ACT	p.T1069T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1069	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGTTCCCATAGGTGACGGTGT	0.572													7	29					0	0	1	0	0
ARHGDIB	397	broad.mit.edu	37	12	15102817	15102817	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:15102817G>A	uc001rcq.1	-	3	288	c.184C>T	c.(184-186)CCG>TCG	p.P62S	ARHGDIB_uc001rcp.1_5'Flank	NM_001175	NP_001166	P52566	GDIR2_HUMAN	Rho GDP dissociation inhibitor (GDI) beta	62					actin cytoskeleton organization|cellular component movement|immune response|multicellular organismal development|negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytoskeleton|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity				0						GGGGCTTTCGGATCTGCAGGA	0.483													40	62					0	0	1	0	0
RERG	85004	broad.mit.edu	37	12	15264278	15264278	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:15264278C>T	uc001rcs.2	-	3	332	c.192G>A	c.(190-192)CAG>CAA	p.Q64Q	RERG_uc001rct.2_Silent_p.Q64Q|RERG_uc010shu.1_Silent_p.Q45Q	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	64	GTP.				negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						CTTTATTCACCTGACCAGCAG	0.353													20	61					0	0	1	0	0
RERG	85004	broad.mit.edu	37	12	15264295	15264295	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:15264295G>A	uc001rcs.2	-	3	315	c.175C>T	c.(175-177)CTA>TTA	p.L59L	RERG_uc001rct.2_Silent_p.L59L|RERG_uc010shu.1_Silent_p.L40L	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	59					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						GCAGTGTCTAGTATCTCCATG	0.338													22	65					0	0	1	0	0
RERGL	79785	broad.mit.edu	37	12	18234186	18234186	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:18234186C>T	uc001rdq.2	-	6	751	c.557G>A	c.(556-558)GGA>GAA	p.G186E	RERGL_uc001rdr.2_Missense_Mutation_p.G185E	NM_024730	NP_079006	Q9H628	RERGL_HUMAN	RERG/RAS-like	186	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity				0						TGATTTAGATCCACTGGGACG	0.383													14	16					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18876454	18876454	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:18876454C>T	uc010sid.1	-	4	349	c.158G>A	c.(157-159)GGA>GAA	p.G53E	PLCZ1_uc001rdv.3_5'UTR|PLCZ1_uc001rdw.3_Intron	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	53	EF-hand.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					GGTGATTCTTCCTTGTTTCAG	0.308													19	30					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33559958	33559958	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:33559958C>T	uc001rll.1	-	3	1140	c.843G>A	c.(841-843)AAG>AAA	p.K281K	SYT10_uc009zju.1_Silent_p.K91K	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	281	Cytoplasmic (Potential).|C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TCTGAAATTTCTTTTTCCTAT	0.358													14	12					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33579330	33579330	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:33579330C>T	uc001rll.1	-	2	549	c.252G>A	c.(250-252)TGG>TGA	p.W84*	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	84	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GTTTGCTTTTCCAGCATGGCC	0.433													10	9					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40740560	40740560	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:40740560C>T	uc001rmg.3	+	42	6236	c.6115C>T	c.(6115-6117)CGT>TGT	p.R2039C	LRRK2_uc009zjw.2_Missense_Mutation_p.R877C|LRRK2_uc001rmi.2_Missense_Mutation_p.R872C	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2039	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTCAGGGTTTCGTGCACCTGA	0.373													16	21					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826205	43826205	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:43826205G>A	uc010skx.1	-	21	2998	c.2998C>T	c.(2998-3000)CGT>TGT	p.R1000C	ADAMTS20_uc001rno.1_Missense_Mutation_p.R154C|ADAMTS20_uc001rnp.1_Missense_Mutation_p.R154C	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1000	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCAGCAAGACGATGGCCAAAG	0.433													21	35					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826601	43826601	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:43826601C>T	uc010skx.1	-	20	2734	c.2734G>A	c.(2734-2736)GGC>AGC	p.G912S	ADAMTS20_uc001rno.1_Missense_Mutation_p.G66S|ADAMTS20_uc001rnp.1_Missense_Mutation_p.G66S	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	912	TSP type-1 3.			WHVIG -> GMLLAK (in Ref. 1; AAO15766).		proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCACTTTTGCCAATAACATGC	0.343													42	51					0	0	1	0	0
IRAK4	51135	broad.mit.edu	37	12	44165129	44165129	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:44165129C>T	uc001rnu.3	+	4	398	c.268C>T	c.(268-270)CAA>TAA	p.Q90*	IRAK4_uc001rnt.3_Nonsense_Mutation_p.Q90*|IRAK4_uc001rnx.3_Intron|IRAK4_uc001rny.3_Intron|IRAK4_uc010sky.1_Intron|IRAK4_uc001rnv.3_5'UTR|IRAK4_uc001rnw.3_5'UTR	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	90	Death.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		TCTTTTGATCCAAAATGAATT	0.413													12	22					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46243434	46243434	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:46243434T>A	uc001ros.1	+	14	1787	c.1787T>A	c.(1786-1788)GTG>GAG	p.V596E	ARID2_uc001ror.2_Missense_Mutation_p.V596E|ARID2_uc009zkg.1_Missense_Mutation_p.V52E|ARID2_uc009zkh.1_Missense_Mutation_p.V223E|ARID2_uc001rou.1_5'Flank	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	596	RFX-type winged-helix.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CATATTCATGTGGTAGGAGTA	0.418													36	63					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48393854	48393854	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:48393854C>T	uc001rqu.2	-	2	321	c.140G>A	c.(139-141)TGG>TAG	p.W47*	COL2A1_uc001rqv.2_Intron	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	47	VWFC.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CTCCGGCTTCCACACATCCTT	0.468													12	18					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48919578	48919578	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:48919578T>A	uc010slu.1	+	1	164	c.164T>A	c.(163-165)CTC>CAC	p.L55H		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	55	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GATTCTTGTCTCCATAAGCCC	0.483													44	59					0	0	1	0	0
PRKAG1	5571	broad.mit.edu	37	12	49397577	49397577	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:49397577C>T	uc001rsy.2	-	9	735	c.666G>A	c.(664-666)CAG>CAA	p.Q222Q	uc001rsw.2_Intron|PRKAG1_uc010smd.1_Silent_p.Q190Q|PRKAG1_uc001rsx.2_Silent_p.Q138Q|PRKAG1_uc001rsz.2_Silent_p.Q231Q|PRKAG1_uc009zlb.2_Silent_p.Q34Q	NM_002733	NP_002724	P54619	AAKG1_HUMAN	AMP-activated protein kinase, noncatalytic	222	CBS 3.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glycolysis|spermatogenesis	cytosol	cAMP-dependent protein kinase activity|cAMP-dependent protein kinase regulator activity|protein kinase binding			kidney(1)	1						AGACTCGATGCTGTACAAAAA	0.542													55	80					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52799753	52799753	+	Silent	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:52799753G>T	uc001sai.1	-	1	424	c.309C>A	c.(307-309)GTC>GTA	p.V103V		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	103	Head.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		GTGCCAGTGGGACCAGCAGGC	0.572													50	57					3.21987e-24	3.27217e-24	1	1	0
KRT2	3849	broad.mit.edu	37	12	53045473	53045473	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:53045473C>T	uc001sat.2	-	1	487	c.454G>A	c.(454-456)GAA>AAA	p.E152K		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	152	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		ACAGAGACTTCGTGGATGCCA	0.418													26	38					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53451406	53451406	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:53451406C>T	uc001sbp.2	+	12	1036	c.901C>T	c.(901-903)CCT>TCT	p.P301S	TENC1_uc001sbl.2_Missense_Mutation_p.P177S|TENC1_uc001sbn.2_Missense_Mutation_p.P311S|TENC1_uc001sbo.1_Missense_Mutation_p.P301S|TENC1_uc001sbq.2_5'Flank|TENC1_uc001sbr.2_5'Flank|TENC1_uc009zmr.2_5'Flank	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	301	C2 tensin-type.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						GAACAGCAGCCCTCTCTTCCT	0.532													72	92					0	0	1	0	0
HOXC5	3222	broad.mit.edu	37	12	54427299	54427299	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:54427299G>A	uc001sew.2	+	1	468	c.393G>A	c.(391-393)CTG>CTA	p.L131L	HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron|MIR615_hsa-mir-615|MI0003628_5'Flank	NM_018953	NP_061826	Q00444	HXC5_HUMAN	homeobox C5	131					regulation of transcription from RNA polymerase II promoter	cell junction|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCGCCGGACTGAGCCAGCCAC	0.622													3	5					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54905870	54905870	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:54905870C>T	uc001sgc.3	+	9	1001	c.922C>T	c.(922-924)CTG>TTG	p.L308L	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Silent_p.L258L	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	308					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						CACCGAGGACCTGTTTAGCAG	0.498													16	20					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420886	55420886	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:55420886C>T	uc001sgp.3	+	2	1041	c.663C>T	c.(661-663)CTC>CTT	p.L221L		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	221					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						AAACACATCTCCTTCATCTCA	0.493													31	46					0	0	1	0	0
OR6C68	403284	broad.mit.edu	37	12	55886864	55886864	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:55886864G>A	uc010spo.1	+	1	718	c.718G>A	c.(718-720)GCC>ACC	p.A240T		NM_001005519	NP_001005519	A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AAAGAAAAAAGCCTTTTCTAC	0.338													21	16					0	0	1	0	0
MBD6	114785	broad.mit.edu	37	12	57921367	57921367	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:57921367C>T	uc001soj.1	+	8	2384	c.2160C>T	c.(2158-2160)TCC>TCT	p.S720S	MBD6_uc001sok.1_Silent_p.S587S|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	720	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CGGGGGCCTCCTCTCTGGGCA	0.587													47	75					0	0	1	0	0
AVIL	10677	broad.mit.edu	37	12	58202061	58202061	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:58202061A>C	uc001sqj.1	-	10	1139	c.1110T>G	c.(1108-1110)GAT>GAG	p.D370E	AVIL_uc009zqe.1_Missense_Mutation_p.D363E|AVIL_uc001sqk.1_5'UTR|AVIL_uc001sql.3_Missense_Mutation_p.D347E	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin	370	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CATCAAATTTATCCTGGAAAA	0.458													8	133					0	0	1	0	0
RPSAP52	204010	broad.mit.edu	37	12	66152108	66152108	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:66152108C>T	uc001sso.2	-	2	836	c.415G>A	c.(415-417)GAA>AAA	p.E139K		NR_026825				SubName: Full=Putative uncharacterized protein RPSAP52;												0						CCCTGAAATTCCTTCTTGGTC	0.478													4	6					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71286524	71286524	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:71286524C>T	uc001swi.1	-	2	708	c.292G>A	c.(292-294)GCC>ACC	p.A98T		NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	98	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CCATCCATGGCCAGCAGATTG	0.458													45	70					0	0	1	0	0
TSPAN8	7103	broad.mit.edu	37	12	71531783	71531783	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:71531783C>T	uc009zrt.1	-	5	556	c.394G>A	c.(394-396)GGG>AGG	p.G132R	TSPAN8_uc001swk.1_Missense_Mutation_p.G132R|TSPAN8_uc001swj.1_Missense_Mutation_p.G132R	NM_004616	NP_004607	P19075	TSN8_HUMAN	transmembrane 4 superfamily member 3	132	Extracellular (Potential).				protein glycosylation	integral to membrane|lysosome	signal transducer activity			skin(2)|lung(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			TCACTTTCCCCTGTGGCGCTC	0.348													134	207					0	0	1	0	0
ZDHHC17	23390	broad.mit.edu	37	12	77244668	77244668	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:77244668G>A	uc001syk.1	+	17	1965	c.1802G>A	c.(1801-1803)CGA>CAA	p.R601Q		NM_015336	NP_056151	Q8IUH5	ZDH17_HUMAN	huntingtin interacting protein 14	601	Cytoplasmic (Potential).				lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding				0						TTTGAATTTCGATGCTGTGGC	0.403													54	61					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78516158	78516158	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:78516158C>T	uc001syp.2	+	16	4361	c.4188C>T	c.(4186-4188)GTC>GTT	p.V1396V	NAV3_uc001syo.2_Silent_p.V1396V|NAV3_uc010sub.1_Silent_p.V896V|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1396	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTCACGAGGTCCAGAGCCTGC	0.547										HNSCC(70;0.22)			23	39					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81627211	81627211	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:81627211T>G	uc001szl.1	+	13	1771	c.1680T>G	c.(1678-1680)AAT>AAG	p.N560K	ACSS3_uc001szm.1_Missense_Mutation_p.N559K|ACSS3_uc001szn.1_Missense_Mutation_p.N242K	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	560						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						ATGTAATAAATGTTGCAGGTC	0.388													40	52					0	0	1	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373174	86373174	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:86373174C>T	uc001tai.3	-	8	2580	c.1330G>A	c.(1330-1332)GGT>AGT	p.G444S	MGAT4C_uc001tal.3_Missense_Mutation_p.G444S|MGAT4C_uc001taj.3_Missense_Mutation_p.G444S|MGAT4C_uc001tak.3_Missense_Mutation_p.G444S|MGAT4C_uc010sum.1_Missense_Mutation_p.G468S|MGAT4C_uc001tah.3_Missense_Mutation_p.G444S	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	444	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TGATTTACACCTGACATTTCA	0.333													9	26					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88381736	88381736	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:88381736C>T	uc001tam.1	-	9	876	c.708G>A	c.(706-708)AAG>AAA	p.K236K	C12orf50_uc001tan.2_Intron	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	236										skin(2)|ovary(1)	3						GAGGACTGTCCTTGTTATCTT	0.323													20	20					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	89985011	89985011	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:89985011C>T	uc001tbh.2	-	20	3594	c.3413G>A	c.(3412-3414)AGA>AAA	p.R1138K	ATP2B1_uc001tbg.2_3'UTR|ATP2B1_uc009zsr.2_RNA|ATP2B1_uc001tbf.2_Missense_Mutation_p.R772K	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	1176	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						AATCGAACTTCTTGATTCCGG	0.373													22	28					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502336	91502336	+	Missense_Mutation	SNP	C	T	T	rs143511085		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:91502336C>T	uc001tbm.2	-	2	810	c.421G>A	c.(421-423)GAT>AAT	p.D141N	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	141	LRR 4.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						AGCTGCAGATCCTCCAGAGAT	0.443													42	36					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99145181	99145181	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:99145181T>A	uc001tge.1	-	25	4041	c.3624A>T	c.(3622-3624)AAA>AAT	p.K1208N	ANKS1B_uc001tgf.1_Missense_Mutation_p.K724N|ANKS1B_uc001tgk.2_Missense_Mutation_p.K505N|ANKS1B_uc010svd.1_Missense_Mutation_p.K214N|ANKS1B_uc001tgd.1_Missense_Mutation_p.K374N|ANKS1B_uc009ztq.2_Missense_Mutation_p.K110N|ANKS1B_uc010sve.1_Missense_Mutation_p.K238N|ANKS1B_uc001tgh.3_Missense_Mutation_p.K214N|ANKS1B_uc001tgi.2_Missense_Mutation_p.K458N|ANKS1B_uc009ztr.2_Missense_Mutation_p.K398N|ANKS1B_uc001tgj.2_Missense_Mutation_p.K374N|ANKS1B_uc009ztp.2_Missense_Mutation_p.K239N|ANKS1B_uc010svf.1_Missense_Mutation_p.K238N|ANKS1B_uc001tgg.3_Missense_Mutation_p.K306N|ANKS1B_uc010svg.1_Missense_Mutation_p.K343N|ANKS1B_uc009zts.1_Missense_Mutation_p.K434N	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	1208	PID.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GTTTGGAGGGTTTGTTTTCAA	0.488													25	28					0	0	1	0	0
EID3	493861	broad.mit.edu	37	12	104698385	104698385	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:104698385T>C	uc001tkw.2	+	1	837	c.673T>C	c.(673-675)TTG>CTG	p.L225L	TXNRD1_uc010swk.1_Intron|TXNRD1_uc010swl.1_Intron|TXNRD1_uc010swm.1_Intron|TXNRD1_uc010swn.1_Intron|TXNRD1_uc010swo.1_Intron|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Intron|TXNRD1_uc001tku.2_Intron|TXNRD1_uc001tko.1_Intron|TXNRD1_uc001tkp.1_Intron|TXNRD1_uc001tkv.1_Intron	NM_001008394	NP_001008395	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0						AGAAAGGATTTTGGGATTGTT	0.398													11	20					0	0	1	0	0
ALDH1L2	160428	broad.mit.edu	37	12	105446646	105446646	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:105446646A>G	uc001tlc.2	-	11	1478	c.1351T>C	c.(1351-1353)TTC>CTC	p.F451L	ALDH1L2_uc009zuo.2_5'UTR|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	451	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						GCATCTGTGAACTGTCCATTT	0.378											OREG0022073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	22					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108035946	108035946	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:108035946C>T	uc001tmk.1	+	14	3441	c.2920C>T	c.(2920-2922)CAG>TAG	p.Q974*	BTBD11_uc001tmj.2_Nonsense_Mutation_p.Q974*|BTBD11_uc001tml.1_Nonsense_Mutation_p.Q511*|BTBD11_uc001tmm.1_Nonsense_Mutation_p.Q53*	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	974	BTB.					integral to membrane	DNA binding			skin(2)|ovary(1)	3						CTCCATCTTTCAGGTGAGCCC	0.522													15	25					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108600113	108600113	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:108600113C>T	uc001tms.2	+	3	1174	c.430C>T	c.(430-432)CGA>TGA	p.R144*	WSCD2_uc001tmt.2_Nonsense_Mutation_p.R144*	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	144	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						TCGGGCCCTTCGAGGAGTGTC	0.522													24	42					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108618589	108618589	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:108618589C>T	uc001tms.2	+	5	1500	c.756C>T	c.(754-756)GCC>GCT	p.A252A	WSCD2_uc001tmt.2_Silent_p.A252A|WSCD2_uc001tmu.2_5'UTR	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	252	WSC 2.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						TGACAGCTGCCATGCTGAACA	0.582													28	35					0	0	1	0	0
CORO1C	23603	broad.mit.edu	37	12	109046160	109046160	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:109046160C>T	uc001tnj.2	-	8	985	c.889G>A	c.(889-891)GAT>AAT	p.D297N	CORO1C_uc009zva.2_Missense_Mutation_p.D350N|CORO1C_uc010sxf.1_Missense_Mutation_p.D260N	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	297	WD 4.				actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						GGGGATTCATCCGTGATCTCA	0.468													51	43					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110230181	110230181	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:110230181G>A	uc001tpj.1	-	11	1973	c.1878C>T	c.(1876-1878)ATC>ATT	p.I626I	TRPV4_uc001tpg.1_Silent_p.I592I|TRPV4_uc001tph.1_Silent_p.I579I|TRPV4_uc001tpi.1_Silent_p.I519I|TRPV4_uc001tpk.1_Silent_p.I626I|TRPV4_uc001tpl.1_Silent_p.I566I	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	626	Helical; (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AAGCGTAGCCGATCATGAAGA	0.532													15	27					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117718532	117718532	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:117718532C>T	uc001twm.1	-	8	2208	c.1522G>A	c.(1522-1524)GAG>AAG	p.E508K		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	508					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GCTCGCACCTCTGTGAACTGC	0.592													28	46					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768185	117768185	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:117768185C>T	uc001twm.1	-	2	1376	c.690G>A	c.(688-690)AAG>AAA	p.K230K		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	230	PIN (nNOS-inhibiting protein) binding.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TCATCTCTGCCTTGGCAGGTG	0.423													42	61					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119583450	119583450	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:119583450T>C	uc001txa.1	+	9	1328	c.1036T>C	c.(1036-1038)TTG>CTG	p.L346L		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	346	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						GGGGGCCATGTTGGAGAATCT	0.597													7	8					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120584968	120584968	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:120584968G>A	uc001txo.2	-	38	4848	c.4835C>T	c.(4834-4836)TCC>TTC	p.S1612F		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1612	HEAT 11.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAGGGCCAGGGATGGGGCATC	0.577													16	31					0	0	1	0	0
MORN3	283385	broad.mit.edu	37	12	122097174	122097174	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:122097174T>G	uc001uax.2	-	2	397	c.226A>C	c.(226-228)ACC>CCC	p.T76P	MORN3_uc001uay.2_RNA	NM_173855	NP_776254	Q6PF18	MORN3_HUMAN	MORN repeat containing 3	76	MORN 2.										0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000409)|Epithelial(86;0.00145)		AGGCTGAGGGTGCCGTAGCCG	0.562													13	49					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124415896	124415896	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:124415896G>A	uc001uft.3	+	73	12464	c.12439G>A	c.(12439-12441)GAG>AAG	p.E4147K	DNAH10_uc001ufu.3_Missense_Mutation_p.E60K	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4147					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGAAGCCATCGAGGCCCTCCC	0.577													17	29					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834288	125834288	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:125834288C>T	uc001uhe.1	+	2	351	c.343C>T	c.(343-345)CCC>TCC	p.P115S		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	115	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GGACAAATTTCCCTTCAACTG	0.468													44	60					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125900147	125900147	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:125900147G>A	uc001uhe.1	+	3	1023	c.1015G>A	c.(1015-1017)GAG>AAG	p.E339K		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	339	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GGCAGTCCAGGAGGAAATTGA	0.542													29	30					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126128626	126128626	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:126128626C>T	uc001uhe.1	+	6	1435	c.1427C>T	c.(1426-1428)TCC>TTC	p.S476F	TMEM132B_uc001uhf.1_5'UTR	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	476	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCAAAGGTTTCCAACAACTGT	0.443													21	34					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129559150	129559150	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:129559150G>A	uc009zyl.1	-	9	2898	c.2570C>T	c.(2569-2571)ACA>ATA	p.T857I	TMEM132D_uc001uia.2_Missense_Mutation_p.T395I	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	857	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGACCTGTCTGTCGTGGTGCC	0.557													12	28					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648726	130648726	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:130648726C>T	uc001uii.2	+	1	1695	c.1239C>T	c.(1237-1239)ATC>ATT	p.I413I	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	413	Helical; Name=5; (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CGTCCTTCATCCTCTCGGGCT	0.627													21	34					0	0	1	0	0
ZNF10	7556	broad.mit.edu	37	12	133727701	133727701	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:133727701A>T	uc009zzb.2	+	3	568	c.121A>T	c.(121-123)AAT>TAT	p.N41Y	ZNF268_uc010tbv.1_5'UTR|ZNF10_uc001ulq.2_Missense_Mutation_p.N41Y	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CGTGTACAGAAATGTGATGCT	0.448													42	46					0	0	1	0	0
DKFZp686A1627	266695	broad.mit.edu	37	13	19625384	19625384	+	RNA	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:19625384A>G	uc001umb.1	-	8		c.3139T>C				NR_002801				Homo sapiens mRNA; cDNA DKFZp686A1627 (from clone DKFZp686A1627).												0						ATCAGGCAGGACTTGGTCACT	0.567													14	22					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20004618	20004618	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:20004618C>T	uc001umd.2	-	18	1503	c.1292G>A	c.(1291-1293)GGA>GAA	p.G431E	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.G320E|TPTE2_uc001ume.2_Missense_Mutation_p.G354E|TPTE2_uc009zzm.2_Missense_Mutation_p.G102E|TPTE2_uc010tcm.1_RNA|TPTE2_uc010tcl.1_Missense_Mutation_p.G102E	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	431	C2 tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CGAACAATTTCCTAATGAAGT	0.328													5	24					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20048175	20048175	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:20048175G>A	uc001umd.2	-	7	482	c.271C>T	c.(271-273)CTC>TTC	p.L91F	TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Intron|TPTE2_uc001ume.2_Missense_Mutation_p.L54F|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	91						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TCGGCAAGGAGGAGAGTGACA	0.294													26	59					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25481089	25481089	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:25481089C>T	uc001upt.3	-	7	1340	c.1087G>A	c.(1087-1089)GGA>AGA	p.G363R	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA|CENPJ_uc001upu.2_5'Flank	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	363					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		GGCAATGGTCCTTCTGCTTCC	0.284													16	10					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25671851	25671851	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:25671851G>A	uc001upy.2	+	1	1576	c.1515G>A	c.(1513-1515)CGG>CGA	p.R505R		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	505					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CGGTTCCACGGTATAAATATG	0.408													48	30					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38248494	38248494	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:38248494C>T	uc001uws.2	-	5	1480	c.1245G>A	c.(1243-1245)TGG>TGA	p.W415*	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Nonsense_Mutation_p.W415*|TRPC4_uc010tey.1_Nonsense_Mutation_p.W415*|TRPC4_uc010abw.2_Nonsense_Mutation_p.W242*|TRPC4_uc010abx.2_Nonsense_Mutation_p.W415*|TRPC4_uc010aby.2_Nonsense_Mutation_p.W415*	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	415	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TAATTTCTCCCCATATGAAGC	0.303													22	10					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39454684	39454684	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:39454684G>A	uc001uwv.2	+	24	9579	c.9270G>A	c.(9268-9270)GGG>GGA	p.G3090G		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	3090	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TCCCCCATGGGAGAGCACCTC	0.597													18	46					0	0	1	0	0
STOML3	161003	broad.mit.edu	37	13	39540966	39540966	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:39540966G>A	uc001uwx.2	-	7	1010	c.872C>T	c.(871-873)GCC>GTC	p.A291V	STOML3_uc010tez.1_Missense_Mutation_p.A282V	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	291	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		AGGACCTCAGGCTTTATTTGG	0.448													52	33					0	0	1	0	0
MRPS31	10240	broad.mit.edu	37	13	41345349	41345349	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:41345349C>T	uc001uxm.3	-	1	1	c.-74_splice	c.e1-1			NM_005830	NP_005821	Q92665	RT31_HUMAN	mitochondrial ribosomal protein S31 precursor							mitochondrion|ribosome	protein domain specific binding				0		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.52e-08)|Epithelial(112;7.63e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000192)|GBM - Glioblastoma multiforme(144;0.00233)|BRCA - Breast invasive adenocarcinoma(63;0.0706)		GCCCTCTCTTCCGCTTCCGGC	0.637													16	7					0	0	1	0	0
C13orf31	144811	broad.mit.edu	37	13	44455654	44455654	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:44455654T>C	uc010acg.2	+	2	1018	c.533T>C	c.(532-534)TTA>TCA	p.L178S	CCDC122_uc010acf.2_5'Flank|C13orf31_uc001uzf.3_Missense_Mutation_p.L178S	NM_001128303	NP_001121775	Q8IV20	CM031_HUMAN	hypothetical protein LOC144811	178											0		Lung NSC(96;0.000163)|all_hematologic(4;0.0127)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Breast(139;0.0364)|Lung SC(185;0.0367)|Acute lymphoblastic leukemia(4;0.138)		GBM - Glioblastoma multiforme(144;0.000573)|BRCA - Breast invasive adenocarcinoma(63;0.121)		AGAGGAAAATTAACTATTATC	0.348													32	22					0	0	1	0	0
KPNA3	3839	broad.mit.edu	37	13	50296138	50296138	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:50296138G>A	uc001vdj.2	-	9	1094	c.679C>T	c.(679-681)CTC>TTC	p.L227F		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3	227	NLS binding site (major) (By similarity).|ARM 4.				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		TTCCTGCAGAGATTGACAATG	0.458													31	87					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52542733	52542733	+	Silent	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:52542733G>T	uc001vfw.2	-	4	1711	c.1554C>A	c.(1552-1554)TCC>TCA	p.S518S	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Silent_p.S518S|ATP7B_uc001vfy.2_Silent_p.S407S|ATP7B_uc010tgt.1_Silent_p.S518S|ATP7B_uc010tgu.1_Silent_p.S518S|ATP7B_uc010tgv.1_Silent_p.S518S|ATP7B_uc010tgw.1_Intron	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	518	HMA 5.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CAACCAACACGGAGAGAACAC	0.512									Wilson_disease				16	50					5.35267e-07	5.37508e-07	1	1	0
LECT1	11061	broad.mit.edu	37	13	53313178	53313178	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:53313178C>T	uc001vhf.2	-	2	312	c.201G>A	c.(199-201)GGG>GGA	p.G67G	LECT1_uc001vhg.2_Silent_p.G67G|LECT1_uc001vhh.2_Silent_p.G94G	NM_007015	NP_008946	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1 isoform 1	67					cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				ovary(2)	2		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		GACTGTCGCTCCCCTTCCAGA	0.612													7	11					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53418961	53418961	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:53418961G>A	uc001vhi.2	-	3	3150	c.2947C>T	c.(2947-2949)CAG>TAG	p.Q983*	PCDH8_uc001vhj.2_Nonsense_Mutation_p.Q886*	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	983	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GTTGACATCTGGGCTGGTGGG	0.627													26	57					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455611	84455611	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:84455611G>A	uc001vlk.2	-	1	918	c.32C>T	c.(31-33)TCT>TTT	p.S11F		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	11						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AAAACAAAGAGACGTCTCCAG	0.468													60	45					0	0	1	0	0
ABCC4	10257	broad.mit.edu	37	13	95816659	95816659	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:95816659G>A	uc001vmd.3	-	16	2267	c.2148C>T	c.(2146-2148)TTC>TTT	p.F716F	ABCC4_uc010afk.2_Intron|ABCC4_uc001vme.2_Silent_p.F716F|ABCC4_uc010tih.1_Silent_p.F641F	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	716	Helical; (Potential).|ABC transmembrane type-1 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	GGAGAATAAGGAAAATGAAGA	0.383													10	44					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96237063	96237063	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:96237063C>T	uc001vmk.2	-	22	3303	c.2451G>A	c.(2449-2451)GCG>GCA	p.A817A	DZIP1_uc001vmi.2_Silent_p.A65A|DZIP1_uc001vmj.2_Silent_p.A293A|DZIP1_uc001vml.2_Silent_p.A798A|DZIP1_uc001vmm.2_5'Flank	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	817					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			GTTCATTTTTCGCAGGTGGAG	0.463													34	87					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96530022	96530022	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:96530022C>A	uc001vmt.2	-	28	3487	c.3317G>T	c.(3316-3318)CGG>CTG	p.R1106L	UGGT2_uc001vmu.1_Missense_Mutation_p.R193L	NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	1106					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						CTGCAGACCCCGAGGAGGCTG	0.388													26	61					1.17739e-12	1.18813e-12	1	1	0
ZIC5	85416	broad.mit.edu	37	13	100617849	100617849	+	Missense_Mutation	SNP	C	T	T	rs140607831		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:100617849C>T	uc001vom.1	-	2	2023	c.1774G>A	c.(1774-1776)GGG>AGG	p.G592R		NM_033132	NP_149123	Q96T25	ZIC5_HUMAN	zinc finger protein of the cerebellum 5	592					cell differentiation	nucleus	DNA binding|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACTGGAGTCCCCACTGATGAG	0.582													57	113					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	107822868	107822868	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:107822868C>T	uc001vql.2	-	3	1870	c.1354G>A	c.(1354-1356)GAA>AAA	p.E452K		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	452						integral to membrane	binding			skin(1)	1						GTTGAGTTTTCTTCCAGCGTG	0.517													38	22					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109318280	109318280	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:109318280C>T	uc001vqt.1	+	2	135	c.9C>T	c.(7-9)ATC>ATT	p.I3I	MYO16_uc010agk.1_Silent_p.I25I	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	3					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AGATGGAAATCGACCAGTGCT	0.493													19	42					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109507818	109507818	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:109507818G>A	uc001vqt.1	+	11	1336	c.1210G>A	c.(1210-1212)GAT>AAT	p.D404N	MYO16_uc010agk.1_Missense_Mutation_p.D426N|MYO16_uc001vqu.1_Missense_Mutation_p.D204N	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	404	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TGCCCCAAACGATGACCTGGC	0.473													27	18					0	0	1	0	0
RAB20	55647	broad.mit.edu	37	13	111176261	111176261	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr13:111176261C>T	uc001vqy.2	-	2	661	c.456G>A	c.(454-456)GAG>GAA	p.E152E		NM_017817	NP_060287	Q9NX57	RAB20_HUMAN	RAB20, member RAS oncogene family	152					protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	all_cancers(4;1.54e-11)|all_epithelial(4;1.22e-06)|all_lung(23;1e-05)|Lung NSC(43;0.000453)|Colorectal(4;0.00323)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.197)			CCACCGCATCCTCCAGCTGCA	0.582													15	39					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248603	20248603	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:20248603G>A	uc010tku.1	+	1	122	c.122G>A	c.(121-123)GGA>GAA	p.G41E		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCCTACCAGGAAATATCCTT	0.423													76	90					0	0	1	0	0
OR4K14	122740	broad.mit.edu	37	14	20483064	20483064	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:20483064C>T	uc010tky.1	-	1	289	c.289G>A	c.(289-291)GGA>AGA	p.G97R		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GCCATACATCCTCCAAAGGAG	0.488													13	23					0	0	1	0	0
OR4K13	390433	broad.mit.edu	37	14	20502267	20502268	+	Missense_Mutation	DNP	GG	AA	AA	rs139197151	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:20502267_20502268GG>AA	uc010tkz.1	-	1	650_651	c.650_651CC>TT	c.(649-651)TCC>TTT	p.S217F		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TGACTCCATAGGAGACAAGCAA	0.49													28	40					0	0	1	0	0
EDDM3A	10876	broad.mit.edu	37	14	21215878	21215878	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:21215878G>A	uc001vyb.2	+	2	206	c.139G>A	c.(139-141)GAG>AAG	p.E47K	EDDM3A_uc001vyc.2_Missense_Mutation_p.E47K	NM_006683	NP_006674	Q14507	EP3A_HUMAN	human epididymis-specific 3 alpha precursor	47					sperm displacement	extracellular space					0						AGAATTCAAAGAGTACAAATG	0.383													25	37					0	0	1	0	0
EDDM3A	10876	broad.mit.edu	37	14	21216002	21216002	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:21216002G>A	uc001vyb.2	+	2	330	c.263G>A	c.(262-264)CGA>CAA	p.R88Q	EDDM3A_uc001vyc.2_Missense_Mutation_p.R88Q	NM_006683	NP_006674	Q14507	EP3A_HUMAN	human epididymis-specific 3 alpha precursor	88					sperm displacement	extracellular space					0						GGGAGCGACCGATATAGAAAT	0.453													19	21					0	0	1	0	0
TPPP2	122664	broad.mit.edu	37	14	21498787	21498787	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:21498787G>A	uc001vzh.2	+	2	235	c.47G>A	c.(46-48)GGA>GAA	p.G16E	NDRG2_uc010tll.1_Intron	NM_173846	NP_776245	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family	16						cytoplasm					0	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GCTGCGTTTGGAGAATCATCA	0.522													9	12					0	0	1	0	0
METTL3	56339	broad.mit.edu	37	14	21967496	21967496	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:21967496G>A	uc001wbc.2	-	9	1564	c.1472C>T	c.(1471-1473)CCC>CTC	p.P491L	METTL3_uc001wbb.2_Missense_Mutation_p.P336L	NM_019852	NP_062826	Q86U44	MTA70_HUMAN	methyltransferase like 3	491					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			pancreas(1)|skin(1)	2	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		GAAGCCTTGGGGATTTCCTTT	0.418													33	62					0	0	1	0	0
MMP14	4323	broad.mit.edu	37	14	23314938	23314938	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:23314938G>A	uc001whc.2	+	10	1673	c.1439G>A	c.(1438-1440)GGG>GAG	p.G480E		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	480	Hemopexin-like 4.|Extracellular (Potential).					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TTCTACAAGGGGAACAAATAC	0.542													36	59					0	0	1	0	0
RBM23	55147	broad.mit.edu	37	14	23374144	23374144	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:23374144A>G	uc001whg.2	-	9	1003	c.804T>C	c.(802-804)GGT>GGC	p.G268G	RBM23_uc001whh.2_Silent_p.G252G|RBM23_uc001whi.2_Silent_p.G234G|RBM23_uc010tne.1_Silent_p.G98G|RBM23_uc001whj.2_Silent_p.G18G|RBM23_uc001whk.1_Silent_p.G268G	NM_001077351	NP_001070819	Q86U06	RBM23_HUMAN	RNA binding motif protein 23 isoform 1	268	RRM 2.				mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		AGTGCAGGGAACCCACATAGA	0.512													68	87					0	0	1	0	0
CMTM5	116173	broad.mit.edu	37	14	23847989	23847989	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:23847989C>T	uc010akm.2	+	3	835	c.391C>T	c.(391-393)CCA>TCA	p.P131S	CMTM5_uc001wjs.2_Intron|CMTM5_uc001wjt.2_Intron|CMTM5_uc010akn.2_Intron|CMTM5_uc001wju.2_Intron|CMTM5_uc010ako.2_Intron	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	131	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		CTGGCATACTCCAGCCGCTGT	0.642													9	26					0	0	1	0	0
NFATC4	4776	broad.mit.edu	37	14	24845860	24845860	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:24845860C>T	uc001wpc.2	+	9	2738	c.2417C>T	c.(2416-2418)TCT>TTT	p.S806F	NFATC4_uc010tok.1_Missense_Mutation_p.S869F|NFATC4_uc010tol.1_Missense_Mutation_p.S869F|NFATC4_uc010alr.2_Intron|NFATC4_uc010tom.1_Missense_Mutation_p.S819F|NFATC4_uc010ton.1_Missense_Mutation_p.S819F|NFATC4_uc010too.1_Intron|NFATC4_uc010alt.2_Missense_Mutation_p.S838F|NFATC4_uc010top.1_Missense_Mutation_p.S838F|NFATC4_uc010toq.1_Intron|NFATC4_uc010tor.1_Intron|NFATC4_uc010tos.1_Missense_Mutation_p.S736F|NFATC4_uc010tot.1_Missense_Mutation_p.S794F|NFATC4_uc010tou.1_Missense_Mutation_p.S736F|NFATC4_uc010tov.1_Intron|NFATC4_uc010tow.1_Intron|NFATC4_uc010alv.2_Missense_Mutation_p.S794F|NFATC4_uc010tox.1_Missense_Mutation_p.S736F|NFATC4_uc001wpd.2_Missense_Mutation_p.S341F|NFATC4_uc010toy.1_Intron|NFATC4_uc010toz.1_Missense_Mutation_p.S341F|NFATC4_uc010tpa.1_Missense_Mutation_p.S94F|NFATC4_uc010tpb.1_Missense_Mutation_p.S94F	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	806	Pro-rich.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		CTGCCATTCTCTCCGCCAGCC	0.642													40	52					0	0	1	0	0
HEATR5A	25938	broad.mit.edu	37	14	31792914	31792914	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:31792914G>A	uc001wrf.3	-	18	2842	c.2765C>T	c.(2764-2766)TCC>TTC	p.S922F	HEATR5A_uc010ami.2_Missense_Mutation_p.S820F|HEATR5A_uc001wrg.1_Missense_Mutation_p.S804F	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1209							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		AAAAGGATGGGATTTTTCATC	0.418													15	32					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33147619	33147619	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:33147619G>A	uc001wrq.2	+	8	3003	c.2833G>A	c.(2833-2835)GAA>AAA	p.E945K	AKAP6_uc010aml.2_Missense_Mutation_p.E942K	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	945					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CAAGCGAAAGGAAGAGTTTGC	0.413													23	24					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33293129	33293129	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:33293129C>T	uc001wrq.2	+	13	6280	c.6110C>T	c.(6109-6111)TCC>TTC	p.S2037F		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2037					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AGCAACATTTCCTGTTGCAAC	0.428													15	29					0	0	1	0	0
ATL1	51062	broad.mit.edu	37	14	51057789	51057789	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:51057789A>G	uc001wyf.3	+	3	654	c.413A>G	c.(412-414)AAA>AGA	p.K138R	ATL1_uc001wyd.3_Missense_Mutation_p.K138R|ATL1_uc001wye.3_Missense_Mutation_p.K138R	NM_015915	NP_056999	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1 isoform a	138	Cytoplasmic.				axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			skin(3)|central_nervous_system(1)	4						CCTGATGGTAAAAAGGTATGA	0.343													13	10					0	0	1	0	0
PTGER2	5732	broad.mit.edu	37	14	52781512	52781512	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:52781512C>T	uc001wzr.2	+	1	497	c.246C>T	c.(244-246)ACC>ACT	p.T82T		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	82	Helical; Name=2; (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	TGCTCGGGACCTGCCTCATCA	0.687													20	20					0	0	1	0	0
MAPK1IP1L	93487	broad.mit.edu	37	14	55529445	55529445	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:55529445C>T	uc001xbq.1	+	3	292	c.128C>T	c.(127-129)CCG>CTG	p.P43L		NM_144578	NP_653179	Q8NDC0	MISSL_HUMAN	MAPK-interacting and spindle-stabilizing	43	Pro-rich.										0						TGGAATAATCCGAGTGCTCCA	0.552													21	24					0	0	1	0	0
KTN1	3895	broad.mit.edu	37	14	56119569	56119570	+	Missense_Mutation	DNP	TT	AA	AA			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:56119569_56119570TT>AA	uc001xcb.2	+	27	2907_2908	c.2605_2606TT>AA	c.(2605-2607)TTA>AAA	p.L869K	KTN1_uc001xce.2_Missense_Mutation_p.L869K|KTN1_uc001xcc.2_Missense_Mutation_p.L869K|KTN1_uc001xcd.2_Missense_Mutation_p.L846K|KTN1_uc010trb.1_Missense_Mutation_p.L869K|KTN1_uc001xcf.1_Missense_Mutation_p.L846K|KTN1_uc010aoq.2_Missense_Mutation_p.L164K	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	869	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						TATTATCAGATTAAAAGGAAAA	0.322			T	RET	papillary thryoid								8	14					0	0	1	0	0
OTX2	5015	broad.mit.edu	37	14	57269062	57269062	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:57269062C>T	uc001xcp.2	-	3	432	c.261G>A	c.(259-261)AAG>AAA	p.K87K	OTX2_uc010aou.2_Silent_p.K87K|OTX2_uc001xcq.2_Silent_p.K95K	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	87	Homeobox.				axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					CTCTTCGATTCTTAAACCATA	0.423													33	61					0	0	1	0	0
SLC38A6	145389	broad.mit.edu	37	14	61518625	61518625	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:61518625A>T	uc001xfg.1	+	14	1287	c.1171A>T	c.(1171-1173)ATT>TTT	p.I391F	SLC38A6_uc001xfh.1_Missense_Mutation_p.I391F|SLC38A6_uc001xfi.2_RNA|SLC38A6_uc001xfj.1_RNA|SLC38A6_uc001xfk.2_RNA|SLC38A6_uc010trz.1_Missense_Mutation_p.I368F	NM_153811	NP_722518	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	391	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TGTTCCTGACATTAGAAATGT	0.328													7	24					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63246518	63246518	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:63246518G>A	uc001xfx.2	-	10	1998	c.1947C>T	c.(1945-1947)GTC>GTT	p.V649V	KCNH5_uc001xfy.2_Intron|KCNH5_uc001xfz.1_Silent_p.V591V	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	649	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		AAAAGTCCAGGACTTTGAGCA	0.478													25	47					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63269224	63269224	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:63269224G>A	uc001xfx.2	-	9	1696	c.1645C>T	c.(1645-1647)CCT>TCT	p.P549S	KCNH5_uc001xfy.2_Missense_Mutation_p.P549S|KCNH5_uc001xfz.1_Missense_Mutation_p.P491S	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	549	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CGAAAAGCAGGATGTTCATTA	0.493													13	25					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63468177	63468177	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:63468177C>T	uc001xfx.2	-	4	356	c.305G>A	c.(304-306)AGA>AAA	p.R102K	KCNH5_uc001xfy.2_Missense_Mutation_p.R102K|KCNH5_uc001xfz.1_Missense_Mutation_p.R44K|KCNH5_uc001xga.2_Missense_Mutation_p.R44K	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	102	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		AACAGGGGTTCCTGTAACAGA	0.438													7	11					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64529517	64529517	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:64529517C>T	uc001xgm.2	+	50	10346	c.10116C>T	c.(10114-10116)TAC>TAT	p.Y3372Y	SYNE2_uc001xgl.2_Silent_p.Y3372Y|SYNE2_uc010apw.1_Silent_p.Y78Y	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3372	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGGATATTTACACTAACCTCA	0.368													10	20					0	0	1	0	0
ZBTB25	7597	broad.mit.edu	37	14	64954344	64954344	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:64954344G>A	uc001xhf.2	-	3	788	c.605C>T	c.(604-606)TCC>TTC	p.S202F	ZBTB25_uc001xhc.2_Intron|ZBTB25_uc001xhg.2_Missense_Mutation_p.S202F	NM_006977	NP_008908	P24278	ZBT25_HUMAN	zinc finger protein 46	202						cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		CTGCTTGATGGAAACTGGGGG	0.567													65	106					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634132	70634132	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:70634132C>T	uc001xly.2	-	2	1762	c.1008G>A	c.(1006-1008)GTG>GTA	p.V336V	SLC8A3_uc001xlw.2_Silent_p.V336V|SLC8A3_uc001xlx.2_Silent_p.V336V|SLC8A3_uc001xlz.2_Silent_p.V336V|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	336	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TGGCCATCTCCACCAGCTGAT	0.507													32	40					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713473	70713473	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:70713473G>A	uc010ttg.1	-	1	1046	c.395C>T	c.(394-396)TCA>TTA	p.S132L		NR_003951				SubName: Full=ADAM21-like protein;												0						ACTTATAAGTGAATTTTTTAT	0.383													26	53					0	0	1	0	0
SYNJ2BP	55333	broad.mit.edu	37	14	70855188	70855188	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:70855188G>A	uc001xmc.3	-	2	327	c.200C>T	c.(199-201)TCG>TTG	p.S67L	SYNJ2BP_uc010arc.2_Intron	NM_018373	NP_060843	P57105	SYJ2B_HUMAN	synaptojanin 2 binding protein	67	PDZ.|Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane					0				all cancers(60;0.00367)|BRCA - Breast invasive adenocarcinoma(234;0.00716)|OV - Ovarian serous cystadenocarcinoma(108;0.0377)		CATTCTCACCGAAAGGATCTT	0.542													20	22					0	0	1	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73444715	73444715	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:73444715G>A	uc001xnm.2	-	8	2195	c.1555C>T	c.(1555-1557)CGT>TGT	p.R519C	ZFYVE1_uc001xnl.2_Missense_Mutation_p.R104C|ZFYVE1_uc010arj.2_Intron	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	519						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		TGCCGACTACGATAGACCACG	0.498													31	30					0	0	1	0	0
HEATR4	399671	broad.mit.edu	37	14	73987670	73987670	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:73987670C>T	uc010tub.1	-	4	1277	c.955G>A	c.(955-957)GAA>AAA	p.E319K	HEATR4_uc010tua.1_Missense_Mutation_p.E272K	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		CTCGTCTTTTCATGGATATCC	0.517													29	38					0	0	1	0	0
C14orf43	91748	broad.mit.edu	37	14	74186144	74186144	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:74186144G>T	uc001xot.2	-	12	3781	c.2998C>A	c.(2998-3000)CAG>AAG	p.Q1000K	C14orf43_uc001xos.2_Missense_Mutation_p.Q265K|C14orf43_uc001xou.2_Missense_Mutation_p.Q1000K|C14orf43_uc010tud.1_Missense_Mutation_p.Q1000K|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	1000					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		TCCGAGGCCTGGCCACCGGCA	0.527													12	18					9.31168e-06	9.34415e-06	1	1	0
LTBP2	4053	broad.mit.edu	37	14	74988710	74988710	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:74988710C>T	uc001xqa.2	-	17	3079	c.2692G>A	c.(2692-2694)GGA>AGA	p.G898R		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	898	EGF-like 5; calcium-binding (Potential).|Cys-rich.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CGCCCTTTTCCCTTGCAGGGG	0.617													8	16					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75265550	75265550	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:75265550C>T	uc001xqj.3	+	5	3674	c.3550C>T	c.(3550-3552)CAC>TAC	p.H1184Y	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	989	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GTATCCATATCACCGGGATGA	0.493													18	29					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75329591	75329591	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:75329591A>G	uc001xqr.1	-	1	947	c.947T>C	c.(946-948)ATC>ACC	p.I316T	PROX2_uc001xqq.1_Intron	NM_001080408	NP_001073877	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	316					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		TCTTGGAGGGATAGGGTACCT	0.527													33	67					0	0	1	0	0
TSHR	7253	broad.mit.edu	37	14	81610463	81610463	+	Silent	SNP	G	A	A	rs149789138	by1000genomes	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:81610463G>A	uc001xvd.1	+	10	2217	c.2061G>A	c.(2059-2061)AGG>AGA	p.R687R		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	687	Cytoplasmic (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CCTTCCAGAGGGATGTGTTCA	0.483			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						73	88					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89123778	89123778	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:89123778G>A	uc001xxg.2	-	28	4132	c.3946C>T	c.(3946-3948)CGC>TGC	p.R1316C	EML5_uc001xxf.2_Missense_Mutation_p.R111C|EML5_uc001xxh.1_Missense_Mutation_p.R455C	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1316						cytoplasm|microtubule				ovary(3)	3						AACATTGGGCGAATATTTGTT	0.313													10	15					0	0	1	0	0
PSMC1	5700	broad.mit.edu	37	14	90730089	90730089	+	Silent	SNP	C	T	T	rs140086070		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:90730089C>T	uc001xyf.2	+	5	411	c.363C>T	c.(361-363)GCC>GCT	p.A121A	PSMC1_uc001xyg.2_Silent_p.A48A|PSMC1_uc001xyh.2_Silent_p.A48A|PSMC1_uc010twh.1_Silent_p.A48A	NM_002802	NP_002793	P62191	PRS4_HUMAN	proteasome 26S ATPase subunit 1	121					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0		all_cancers(154;0.142)		COAD - Colon adenocarcinoma(157;0.21)		ACAATCATGCCATCGTGTCTA	0.478													23	28					0	0	1	0	0
CALM1	801	broad.mit.edu	37	14	90870227	90870227	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:90870227C>T	uc001xyl.1	+	4	402	c.200C>T	c.(199-201)CCC>CTC	p.P67L	CALM1_uc010atq.1_Missense_Mutation_p.P68L|CALM1_uc010atr.1_Intron|CALM1_uc001xym.1_Missense_Mutation_p.P31L	NM_006888	NP_008819	P62158	CALM_HUMAN	calmodulin 1 isoform 1	67	EF-hand 2.|2.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			central_nervous_system(1)	1		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.208)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	ATTGACTTCCCCGAATTTTTG	0.388													10	13					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91744483	91744483	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:91744483G>A	uc010aty.2	-	29	4940	c.4841C>T	c.(4840-4842)GCC>GTC	p.A1614V	CCDC88C_uc001xzj.2_Missense_Mutation_p.A138V|CCDC88C_uc001xzi.2_Missense_Mutation_p.A64V	NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1614					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				GGGCAAAGTGGCCAGGTCCCT	0.682													10	12					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91760626	91760626	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:91760626T>A	uc010aty.2	-	23	4102	c.4003A>T	c.(4003-4005)AAT>TAT	p.N1335Y		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1335	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				AGGTGATGATTTTCTTCCTCC	0.428													33	40					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91791245	91791245	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:91791245C>T	uc010aty.2	-	12	1319	c.1220G>A	c.(1219-1221)CGA>CAA	p.R407Q		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	407	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				CTCCTCAATTCGTTTCTTATC	0.552													13	23					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92264669	92264669	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:92264669C>T	uc001xzu.3	-	7	903	c.712G>A	c.(712-714)GAA>AAA	p.E238K	TC2N_uc001xzt.3_Missense_Mutation_p.E238K|TC2N_uc010auc.2_Missense_Mutation_p.E238K|TC2N_uc001xzv.3_Missense_Mutation_p.E238K	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	238						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		CAGATCTGTTCTACTGAAGAA	0.303													16	25					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95089958	95089958	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:95089958A>G	uc001ydp.2	+	5	1158	c.1079A>G	c.(1078-1080)AAG>AGG	p.K360R	SERPINA3_uc001ydo.3_Missense_Mutation_p.K385R|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.K360R|SERPINA3_uc001yds.2_Missense_Mutation_p.K360R|SERPINA3_uc010avg.2_Missense_Mutation_p.K360R	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	360					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		GTGGTCCATAAGGCTGTGCTT	0.522													23	37					0	0	1	0	0
DICER1	23405	broad.mit.edu	37	14	95556876	95556876	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:95556876G>A	uc001ydw.2	-	28	5910	c.5728C>T	c.(5728-5730)CGA>TGA	p.R1910*	DICER1_uc010avh.1_Nonsense_Mutation_p.R808*|DICER1_uc001ydv.2_Nonsense_Mutation_p.R1900*|DICER1_uc001ydx.2_Nonsense_Mutation_p.R1910*	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1910	DRBM.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TTGAGGCTTCGGAGGGCTCTT	0.398			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				62	79					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99640587	99640587	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:99640587G>A	uc001yga.2	-	4	2853	c.2586C>T	c.(2584-2586)CCC>CCT	p.P862P	BCL11B_uc001ygb.2_Silent_p.P791P	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	862	C2H2-type 6.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		AGACGCTGAAGGGCATCTGGC	0.582			T	TLX3	T-ALL								12	16					0	0	1	0	0
DIO3	1735	broad.mit.edu	37	14	102028470	102028470	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:102028470C>T	uc010txq.1	+	2	783	c.559C>T	c.(559-561)CCC>TCC	p.P187S	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	187	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				CACGGACTCTCCCTACATCAT	0.637													43	70					0	0	1	0	0
PPP2R5C	5527	broad.mit.edu	37	14	102391518	102391518	+	Missense_Mutation	SNP	G	A	A	rs147942579	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:102391518G>A	uc001yko.2	+	14	1624	c.1484G>A	c.(1483-1485)CGC>CAC	p.R495H	PPP2R5C_uc010txr.1_Missense_Mutation_p.R526H|PPP2R5C_uc001ykk.2_Missense_Mutation_p.R511H|PPP2R5C_uc001ykp.2_Missense_Mutation_p.R456H	NM_002719	NP_002710	Q13362	2A5G_HUMAN	gamma isoform of regulatory subunit B56, protein	495					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein binding|protein phosphatase type 2A regulator activity|protein phosphatase type 2A regulator activity			ovary(1)|breast(1)	2						CTTGCACGCCGCAAGTCCGAG	0.542													4	155					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103404697	103404697	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:103404697G>A	uc001ymi.1	-	35	5111	c.4879C>T	c.(4879-4881)CTG>TTG	p.L1627L		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1627					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TGGCGAGCCAGGTTGGTGGGA	0.667													48	51					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105177426	105177426	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:105177426C>T	uc001ypb.2	+	15	2464	c.2321C>T	c.(2320-2322)ACC>ATC	p.T774I	INF2_uc010tyi.1_Missense_Mutation_p.T774I|INF2_uc001ypc.2_Missense_Mutation_p.T774I|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	774	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		GGCAGCCACACCGGTGACGCC	0.632													2	3					0	0	1	0	0
MTA1	9112	broad.mit.edu	37	14	105936237	105936237	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:105936237C>T	uc001yqx.2	+	20	2092	c.1905C>T	c.(1903-1905)ATC>ATT	p.I635I	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Silent_p.I400I	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	635					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		TGCGCCTGATCCGGGGGGGCT	0.672													6	5					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106405789	106405789	+	RNA	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:106405789G>A	uc010tyt.1	-	2358		c.42275C>T								Parts of antibodies, mostly variable regions.												0						TCTCGATGGGGACTGCCTGAT	0.527													39	67					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106805374	106805374	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:106805374C>T	uc010tyt.1	-	360		c.13834G>A			uc001ysw.1_5'Flank					Parts of antibodies, mostly variable regions.												0						CCAGGCCCTTCCCTGGGTGCT	0.542													35	258					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106993902	106993902	+	RNA	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:106993902G>A	uc010tyt.1	-	187		c.8545C>T								Parts of antibodies, mostly variable regions.												0						TCTGGAGATGGTGAATCGGCC	0.512													6	115					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	107042487	107042487	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:107042487C>T	uc010tyt.1	-	149		c.7097G>A								Parts of antibodies, mostly variable regions.												0						TAGTATTTCTCACTTCCGTCA	0.537													22	27					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	107183621	107183621	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr14:107183621C>T	uc010tyt.1	-	29		c.1936G>A								Parts of antibodies, mostly variable regions.												0						GAAGGTGAATCCAGAGGCTGC	0.577													6	76					0	0	1	0	0
Unknown	0	broad.mit.edu	37	15	20489448	20489448	+	RNA	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:20489448G>A	uc001ytf.1	+	3		c.436G>A								full-length cDNA clone CS0DI026YN18 of Placenta Cot 25-normalized of Homo sapiens (human).																		ATCACCAGTGGAAAACACAAC	0.413													15	67					0	0	1	0	0
LOC646214	646214	broad.mit.edu	37	15	21937321	21937321	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:21937321C>T	uc010tzj.1	-	1		c.3419G>A				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						ACCTTCTGTCCCAGTGCAACG	0.348													13	69					0	0	1	0	0
LOC646214	646214	broad.mit.edu	37	15	21937437	21937437	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:21937437C>T	uc010tzj.1	-	1		c.3303G>A				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						TTAGTTTCTCCATAATCTCTT	0.383													17	98					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22369005	22369005	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:22369005C>T	uc010tzu.1	+	1	430	c.430C>T	c.(430-432)CTG>TTG	p.L144L	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTGCTGTATCCTGGTGGCTCT	0.502													54	192					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890702	23890702	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:23890702C>T	uc001ywj.3	-	1	474	c.379G>A	c.(379-381)GGC>AGC	p.G127S		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TTAGAGGAGCCCCTGCGGTCT	0.587													8	24					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890954	23890954	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:23890954C>T	uc001ywj.3	-	1	222	c.127G>A	c.(127-129)GAG>AAG	p.E43K		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		AAGGGCTGCTCCAGCTGGACC	0.701													4	9					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25959148	25959148	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:25959148G>T	uc010ayu.2	-	10	2123	c.2017C>A	c.(2017-2019)CAG>AAG	p.Q673K		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	673	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TTGTCCGCCTGGCTGCTGTAG	0.682													20	43					1.56452e-12	1.57768e-12	1	1	0
HERC2	8924	broad.mit.edu	37	15	28412966	28412966	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:28412966G>A	uc001zbj.2	-	68	10527	c.10421C>T	c.(10420-10422)TCC>TTC	p.S3474F		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3474					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GTCCTCAGAGGAAACAATCTA	0.522													56	35					0	0	1	0	0
C15orf53	400359	broad.mit.edu	37	15	38990343	38990343	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:38990343G>A	uc001zkf.1	+	2	147	c.137G>A	c.(136-138)GGA>GAA	p.G46E		NM_207444	NP_997327	Q8NAA6	CO053_HUMAN	hypothetical protein LOC400359	46											0		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		ttacagggaggaaagctgagg	0.119													12	24					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40659787	40659787	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:40659787C>T	uc001zlk.1	+	8	1563	c.1474C>T	c.(1474-1476)CCC>TCC	p.P492S		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	492	Helical; (Potential).|SSD.				smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CACGGTGTACCCCTTGCTGGC	0.622													34	89					0	0	1	0	0
GCHFR	2644	broad.mit.edu	37	15	41059480	41059481	+	Missense_Mutation	DNP	GG	AA	AA	rs149719928	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:41059480_41059481GG>AA	uc001zmr.1	+	3	282_283	c.188_189GG>AA	c.(187-189)AGG>AAA	p.R63K	GCHFR_uc010ucr.1_Missense_Mutation_p.R52K|C15orf62_uc010bby.2_5'Flank	NM_005258	NP_005249	P30047	GFRP_HUMAN	GTP cyclohydrolase I feedback regulatory	63					negative regulation of biosynthetic process|neurotransmitter metabolic process|nitric oxide biosynthetic process	cytosol|dendrite|melanosome|nuclear membrane				ovary(1)	1		all_cancers(109;3.3e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		CTGGAACGCAGGGGCTTCCGTG	0.599													37	95					0	0	1	0	0
DLL4	54567	broad.mit.edu	37	15	41224549	41224549	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:41224549G>A	uc001zng.1	+	6	1074	c.754G>A	c.(754-756)GAA>AAA	p.E252K		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	252	EGF-like 2.|Extracellular (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GCTGTGTAACGAATGCATCCC	0.622													44	122					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42054441	42054441	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:42054441C>T	uc010ucy.1	+	22	7806	c.7625C>T	c.(7624-7626)CCC>CTC	p.P2542L	MGA_uc010ucz.1_Missense_Mutation_p.P2333L|MGA_uc010uda.1_Missense_Mutation_p.P1158L	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2503						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GACATATCTCCCAGAATTAGC	0.393													58	33					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42178130	42178130	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:42178130G>A	uc001zos.2	-	7	1551	c.1218C>T	c.(1216-1218)TTC>TTT	p.F406F		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	441	Spectrin 2.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CATCCTTAAGGAAACTCTCCC	0.667													4	10					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42276716	42276716	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:42276716C>T	uc001zow.1	-	18	2217	c.2217G>A	c.(2215-2217)ATG>ATA	p.M739I	PLA2G4E_uc010udc.1_Missense_Mutation_p.M211I|PLA2G4E_uc001zov.1_Missense_Mutation_p.M392I	NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	756	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		GGGGGTTCTCCATCAGGTAGC	0.507													40	32					0	0	1	0	0
CAPN3	825	broad.mit.edu	37	15	42678418	42678418	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:42678418C>T	uc001zpn.1	+	3	739	c.433C>T	c.(433-435)CTT>TTT	p.L145F	CAPN3_uc001zpk.1_5'UTR|CAPN3_uc001zpl.1_Missense_Mutation_p.L58F|CAPN3_uc010udf.1_Missense_Mutation_p.L58F|CAPN3_uc010udg.1_Missense_Mutation_p.L58F|CAPN3_uc001zpo.1_Missense_Mutation_p.L145F|CAPN3_uc001zpp.1_Missense_Mutation_p.L145F	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	145	Calpain catalytic.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CCAGCACCTTCTTTTCCGAGT	0.542											OREG0023085	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	82					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43489561	43489561	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:43489561A>T	uc001zra.3	-	13	2315	c.2015T>A	c.(2014-2016)ATG>AAG	p.M672K	EPB42_uc001zqz.3_Missense_Mutation_p.M339K|EPB42_uc010bde.2_3'UTR|EPB42_uc001zrb.3_Missense_Mutation_p.M702K|EPB42_uc010udm.1_Missense_Mutation_p.M594K	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	672					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GTTCTGGAACATGTTGCAGTC	0.502													27	46					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43527779	43527779	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:43527779G>A	uc001zrd.1	-	10	1610	c.1602C>T	c.(1600-1602)TCC>TCT	p.S534S	TGM5_uc001zrc.1_Silent_p.S191S|TGM5_uc001zre.1_Silent_p.S452S	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	534					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CCTTGAACTGGGAGGACATGT	0.562													21	57					0	0	1	0	0
TRIM69	140691	broad.mit.edu	37	15	45059941	45059941	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:45059941G>A	uc001zuf.2	+	8	2369	c.1474G>A	c.(1474-1476)GAA>AAA	p.E492K	TRIM69_uc001zui.1_Missense_Mutation_p.E288K|TRIM69_uc010bdy.1_Missense_Mutation_p.E271K|TRIM69_uc001zug.1_Missense_Mutation_p.E492K|TRIM69_uc001zuh.1_Missense_Mutation_p.E333K	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	492	B30.2/SPRY.				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		AGAGAATAAAGAACCATTGCA	0.358													13	37					0	0	1	0	0
SHC4	399694	broad.mit.edu	37	15	49254728	49254728	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:49254728G>A	uc001zxb.1	-	1	914	c.485C>T	c.(484-486)TCG>TTG	p.S162L		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	162	CH2.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		AAGCGGGCACGAATCAGGGGT	0.612													18	52					0	0	1	0	0
COPS2	9318	broad.mit.edu	37	15	49436468	49436468	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:49436468C>T	uc001zxf.2	-	3	281	c.202G>A	c.(202-204)GGA>AGA	p.G68R	COPS2_uc001zxh.2_Missense_Mutation_p.G68R|COPS2_uc010ufa.1_Intron	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	68					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		GCTTTAAATCCCCATTCTCCT	0.284													13	30					0	0	1	0	0
KIAA1370	56204	broad.mit.edu	37	15	52902537	52902537	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:52902537T>C	uc002acg.3	-	6	727	c.574A>G	c.(574-576)ACT>GCT	p.T192A	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Missense_Mutation_p.T104A|KIAA1370_uc010ugf.1_Missense_Mutation_p.T199A	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	192											0				all cancers(107;0.0803)		TCAATTGGAGTCTGTGAAAAA	0.368													58	30					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55931947	55931947	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:55931947G>A	uc002adg.2	-	13	2265	c.2217C>T	c.(2215-2217)TTC>TTT	p.F739F		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	739	Fibronectin type-III 4.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TCCAGTGCAGGAAGATGGAAG	0.498													27	93					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65499177	65499177	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:65499177C>T	uc002aon.2	-	4	548	c.367G>A	c.(367-369)GAG>AAG	p.E123K		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	123					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						GGCCGCTGCTCCCTGTTGAGG	0.642													31	80					0	0	1	0	0
SMAD6	4091	broad.mit.edu	37	15	67073433	67073433	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:67073433G>A	uc002aqf.2	+	4	1974	c.1051G>A	c.(1051-1053)GAC>AAC	p.D351N	SMAD6_uc010bhx.2_RNA|SMAD6_uc002aqg.2_Missense_Mutation_p.D90N	NM_005585	NP_005576	O43541	SMAD6_HUMAN	SMAD family member 6 isoform 1	351	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			skin(1)	1						TGCGGTGTACGACCAGGCCGT	0.682													10	4					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67629389	67629389	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:67629389C>T	uc002aqo.1	+	5	511	c.464C>T	c.(463-465)CCC>CTC	p.P155L	IQCH_uc010ujv.1_Intron|IQCH_uc002aqn.1_Intron|IQCH_uc002aqq.1_Intron|IQCH_uc002aqp.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	155										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		TGCACAGATCCCTATTTCACT	0.348													66	65					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71300720	71300720	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:71300720C>T	uc002asw.2	+	12	1419	c.1172C>T	c.(1171-1173)CCT>CTT	p.P391L	LRRC49_uc002asu.2_Missense_Mutation_p.P381L|LRRC49_uc002asx.2_Missense_Mutation_p.P347L|LRRC49_uc010ukf.1_Missense_Mutation_p.P396L|LRRC49_uc002asy.2_Missense_Mutation_p.P97L|LRRC49_uc002asz.2_Missense_Mutation_p.P363L	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	391						cytoplasm|microtubule				ovary(1)	1						TTTTCCAGGCCTCTAGACTCA	0.373													19	53					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72144482	72144482	+	Nonsense_Mutation	SNP	G	A	A	rs145598484		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:72144482G>A	uc002atl.3	-	36	6939	c.6466C>T	c.(6466-6468)CGA>TGA	p.R2156*	MYO9A_uc002atj.2_Nonsense_Mutation_p.R69*|MYO9A_uc002atk.2_Nonsense_Mutation_p.R951*	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	2156	Tail.|Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						CCCATAGCTCGAAGAAATTCC	0.418													46	35					0	0	1	0	0
TMEM202	338949	broad.mit.edu	37	15	72691212	72691212	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:72691212C>A	uc002auq.2	+	2	300	c.300C>A	c.(298-300)AAC>AAA	p.N100K	TMEM202_uc002aur.2_Intron	NM_001080462	NP_001073931	A6NGA9	TM202_HUMAN	transmembrane protein 202	100						integral to membrane				central_nervous_system(1)|skin(1)	2						CCTTATGCAACCATGAGCTGT	0.537													4	137					0.150653	0.150758	1	1	0
NPTN	27020	broad.mit.edu	37	15	73862573	73862573	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:73862573C>A	uc002avs.2	-	6	1229	c.1032G>T	c.(1030-1032)TTG>TTT	p.L344F	NPTN_uc010bjc.2_Missense_Mutation_p.L344F|NPTN_uc002avt.2_Missense_Mutation_p.L228F|NPTN_uc002avr.2_Missense_Mutation_p.L228F|NPTN_uc010ula.1_Missense_Mutation_p.L139F	NM_012428	NP_036560	Q9Y639	NPTN_HUMAN	neuroplastin isoform b precursor	344	Helical; (Potential).				elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding				0						CCAGAATTCCCAAGAAAGGCC	0.522													29	65					1.08312e-15	1.09607e-15	1	1	0
STRA6	64220	broad.mit.edu	37	15	74476262	74476262	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:74476262G>A	uc002axk.2	-	14	1417	c.1235C>T	c.(1234-1236)CCC>CTC	p.P412L	STRA6_uc002axi.2_Missense_Mutation_p.P221L|STRA6_uc010ulh.1_Missense_Mutation_p.P450L|STRA6_uc002axj.2_Missense_Mutation_p.P451L|STRA6_uc010bji.2_Missense_Mutation_p.P412L|STRA6_uc002axl.2_Missense_Mutation_p.P344L|STRA6_uc002axm.2_Missense_Mutation_p.P412L|STRA6_uc002axn.2_Missense_Mutation_p.P403L|STRA6_uc010uli.1_Missense_Mutation_p.P449L|STRA6_uc010bjj.1_RNA	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	412	Extracellular (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						TTGGCGGGAGGGATGGGGACT	0.617													53	39					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74640303	74640303	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:74640303G>A	uc002axt.2	-	2	518	c.363C>T	c.(361-363)TTC>TTT	p.F121F	CYP11A1_uc002axs.2_5'UTR|CYP11A1_uc010bjm.1_Intron|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Silent_p.F121F|CYP11A1_uc010ulj.1_5'UTR|CYP11A1_uc010bjq.2_Silent_p.F121F	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	121					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	GCGGGATGAGGAATCGTTCTG	0.577													19	58					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81627296	81627296	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:81627296C>T	uc002bgo.1	-	21	2224	c.2224G>A	c.(2224-2226)GAA>AAA	p.E742K	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	742	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						TTGGTGCTTTCTTCCTGGGTC	0.542													38	17					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90176402	90176402	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:90176402G>C	uc002bof.2	-	13	2765	c.2688C>G	c.(2686-2688)AAC>AAG	p.N896K	KIF7_uc010upw.1_Missense_Mutation_p.N382K	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	896	Potential.				microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CCACAGAGCCGTTGCTGCCAC	0.627													5	13					0	0	1	0	0
WDR93	56964	broad.mit.edu	37	15	90281358	90281358	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:90281358C>T	uc002boj.2	+	16	1953	c.1852C>T	c.(1852-1854)CTG>TTG	p.L618L	WDR93_uc010bnr.2_Silent_p.L590L|WDR93_uc010upz.1_Silent_p.L335L	NM_020212	NP_064597	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	618					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			ovary(2)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CTGCCCACTCCTGGAAAATAT	0.448													96	222					0	0	1	0	0
FURIN	5045	broad.mit.edu	37	15	91424778	91424778	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:91424778C>T	uc002bpu.1	+	16	2271	c.2055C>T	c.(2053-2055)TCC>TCT	p.S685S	FES_uc010uqj.1_5'Flank|FES_uc010uqk.1_5'Flank|FES_uc002bpw.2_5'Flank|FES_uc002bpv.2_5'Flank	NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	685	Cys-rich.				cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GCCGAGAGTCCCCGCCACAGC	0.721													61	107					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94883460	94883460	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:94883460C>T	uc002btj.2	+	5	878	c.813C>T	c.(811-813)TTC>TTT	p.F271F	MCTP2_uc010urg.1_Silent_p.F271F|MCTP2_uc002bti.2_Silent_p.F271F|MCTP2_uc010boj.2_5'UTR|MCTP2_uc010bok.2_Silent_p.F271F|MCTP2_uc002btg.3_Silent_p.F271F|MCTP2_uc002bth.3_Silent_p.F271F	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	271	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CATCTGATTTCATGGGTTCTG	0.323													51	48					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101528919	101528919	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr15:101528919C>T	uc002bwr.2	+	5	833	c.514C>T	c.(514-516)CTG>TTG	p.L172L	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bwq.1_Silent_p.L172L	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	172	ANK 3.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTGAAGCTCCTGGTCCTGAC	0.632													31	79					0	0	1	0	0
RHBDF1	64285	broad.mit.edu	37	16	113625	113625	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:113625G>A	uc002cfl.3	-	7	570	c.422C>T	c.(421-423)CCC>CTC	p.P141L	RHBDF1_uc010uty.1_Missense_Mutation_p.P164L|RHBDF1_uc010utz.1_Missense_Mutation_p.P141L|RHBDF1_uc010bqo.1_RNA	NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	141	Cytoplasmic (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				GTAGAGTGGGGGTGGCGTCTC	0.642													28	35					0	0	1	0	0
TELO2	9894	broad.mit.edu	37	16	1547058	1547058	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:1547058C>T	uc002cly.2	+	4	926	c.635C>T	c.(634-636)TCC>TTC	p.S212F	TELO2_uc010uvg.1_Missense_Mutation_p.S212F	NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	212						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				TCCTCCGTGTCCTTCGTGTCT	0.612													12	10					0	0	1	0	0
OR1F1	4992	broad.mit.edu	37	16	3254555	3254555	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:3254555C>T	uc010uwu.1	+	1	309	c.309C>T	c.(307-309)TTC>TTT	p.F103F		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGATGTATTTCGTTTTCATGT	0.493													69	103					0	0	1	0	0
PMM2	5373	broad.mit.edu	37	16	8900254	8900255	+	Missense_Mutation	DNP	CC	TT	TT	rs80338700		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:8900254_8900255CC>TT	uc002czf.3	+	4	407_408	c.337_338CC>TT	c.(337-339)CCG>TTG	p.P113L	PMM2_uc010uyf.1_RNA|PMM2_uc010uyg.1_Missense_Mutation_p.P30L|PMM2_uc010uyh.1_Intron|PMM2_uc010buj.2_RNA|PMM2_uc010uyi.1_Intron|PMM2_uc010uye.1_Missense_Mutation_p.P113L	NM_000303	NP_000294	O15305	PMM2_HUMAN	phosphomannomutase 2	113			P -> L (in CDG1A).		dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			ovary(1)	1						AATTAAACTCCCGAAGAAGAGG	0.401													13	20					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9927992	9927992	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:9927992C>T	uc002czo.3	-	8	2295	c.1747G>A	c.(1747-1749)GGA>AGA	p.G583R	GRIN2A_uc010uym.1_Missense_Mutation_p.G583R|GRIN2A_uc010uyn.1_Missense_Mutation_p.G426R|GRIN2A_uc002czr.3_Missense_Mutation_p.G583R	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	583	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTGTTGTATCCAACAGGGCTG	0.398													46	61					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10032409	10032409	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:10032409C>T	uc002czo.3	-	3	963	c.415_splice	c.e3-1	p.D139_splice	GRIN2A_uc010uym.1_Splice_Site_p.D139_splice|GRIN2A_uc010uyn.1_Splice_Site|GRIN2A_uc002czr.3_Splice_Site_p.D139_splice	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform						response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACGTCGGATCCTGCCAGTGAA	0.463													22	19					0	0	1	0	0
PRM2	5620	broad.mit.edu	37	16	11370185	11370185	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:11370185C>T	uc002dau.1	-	1	153	c.43G>A	c.(43-45)GAG>AAG	p.E15K	C16orf75_uc002daq.1_Intron|PRM3_uc002dat.1_5'Flank|PRM2_uc010bus.1_Missense_Mutation_p.E15K	NM_002762	NP_002753	P04554	PRM2_HUMAN	protamine 2	15					chromosome condensation|multicellular organismal development	nucleoplasm|nucleosome	DNA binding				0						CTGTACACCTCGTGCGAGCGT	0.642													16	25					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15851708	15851708	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:15851708G>A	uc002ddy.2	-	13	1658	c.1551C>T	c.(1549-1551)CCC>CCT	p.P517P	MYH11_uc002ddv.2_Silent_p.P524P|MYH11_uc002ddw.2_Silent_p.P517P|MYH11_uc002ddx.2_Silent_p.P524P|MYH11_uc010bvg.2_Silent_p.P349P|MYH11_uc002dea.1_Silent_p.P223P	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	517	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GCTCGATGCAGGGCTGTAGGT	0.622			T	CBFB	AML								16	26					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16244078	16244078	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:16244078C>T	uc002den.3	-	31	4461	c.4424G>A	c.(4423-4425)GGG>GAG	p.G1475E	ABCC6_uc010bvo.2_RNA|ABCC6_uc002dem.2_Missense_Mutation_p.G227E	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	1475	Cytoplasmic (By similarity).|ABC transporter 2.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TGCCACCTGCCCCTTGTCCAT	0.652													8	30					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19020501	19020501	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:19020501C>T	uc002dfq.2	+	2	205	c.75C>T	c.(73-75)CTC>CTT	p.L25L	TMC7_uc010vao.1_Silent_p.L25L|TMC7_uc002dfp.2_Silent_p.L25L|TMC7_uc010vap.1_5'UTR	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	25	Extracellular (Potential).					integral to membrane				skin(2)|ovary(1)	3						TAGAGAACCTCTCTCTAGACT	0.468													47	74					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20477031	20477031	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:20477031C>T	uc010bwe.2	+	4	609	c.370C>T	c.(370-372)CTG>TTG	p.L124L	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Silent_p.L45L|ACSM2A_uc002dhf.3_Silent_p.L124L|ACSM2A_uc002dhg.3_Silent_p.L124L|ACSM2A_uc010vay.1_Silent_p.L45L	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	124					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GCTGGTGATCCTGGGCTGCAT	0.582													16	10					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20480865	20480865	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:20480865G>A	uc010bwe.2	+	5	659	c.420G>A	c.(418-420)ATG>ATA	p.M140I	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Missense_Mutation_p.M61I|ACSM2A_uc002dhf.3_Missense_Mutation_p.M140I|ACSM2A_uc002dhg.3_Missense_Mutation_p.M140I|ACSM2A_uc010vay.1_Missense_Mutation_p.M61I	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	140					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CCATCCAGATGAAATCCACTG	0.423													16	37					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21008734	21008734	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:21008734C>T	uc010vbe.1	-	44	6472	c.6472G>A	c.(6472-6474)GAG>AAG	p.E2158K		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2158	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTCAGGAGCTCGATGGGTGGC	0.532													26	54					0	0	1	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147561	26147561	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:26147561G>A	uc002dof.2	+	2	1755	c.1363G>A	c.(1363-1365)GAT>AAT	p.D455N		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	455	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		GGAAGAGGGTGATAAATGAGG	0.468													10	16					0	0	1	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29891326	29891326	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:29891326C>A	uc002duq.3	-	9	1672	c.1432G>T	c.(1432-1434)GAC>TAC	p.D478Y	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.D408Y|SEZ6L2_uc002dur.3_Missense_Mutation_p.D408Y|SEZ6L2_uc002dus.3_Missense_Mutation_p.D364Y|SEZ6L2_uc010vec.1_Missense_Mutation_p.D478Y|SEZ6L2_uc010ved.1_Missense_Mutation_p.D434Y	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	478	Sushi 2.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TACTCAGGGTCCGTGGTAGTG	0.582													11	62					4.68919e-08	4.722e-08	1	1	0
C16orf92	146378	broad.mit.edu	37	16	30035187	30035187	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:30035187C>T	uc002dvs.2	+	2	291	c.270C>T	c.(268-270)CCC>CCT	p.P90P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|C16orf92_uc002dvr.2_Silent_p.P68P	NM_001109660	NP_001103130	Q96LL3	CP092_HUMAN	hypothetical protein LOC146378 isoform 2	90						integral to membrane					0						GAGAGAAACCCATCGTGTTCA	0.557													17	33					0	0	1	0	0
STX4	6810	broad.mit.edu	37	16	31045633	31045633	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:31045633C>T	uc002eal.2	+	3	443	c.219C>T	c.(217-219)CCC>CCT	p.P73P	STX4_uc002eak.2_Silent_p.P71P|STX4_uc002eam.2_5'UTR	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	73	Cytoplasmic (Potential).|Potential.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						TGGCCACGCCCCTTCCCGAGG	0.602													22	43					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51173535	51173535	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:51173535C>T	uc010vgs.1	-	2	2629	c.2598G>A	c.(2596-2598)TTG>TTA	p.L866L	SALL1_uc010vgr.1_Silent_p.L769L|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	866					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TCTGATTTTCCAAAGCAGCGA	0.552													23	30					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51173934	51173934	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:51173934G>A	uc010vgs.1	-	2	2230	c.2199C>T	c.(2197-2199)CCC>CCT	p.P733P	SALL1_uc010vgr.1_Silent_p.P636P|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	733					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TACACTTAAAGGGCCTCTCCC	0.542													28	31					0	0	1	0	0
Unknown	0	broad.mit.edu	37	16	53404718	53404718	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:53404718C>T	uc002ehh.2	-	1		c.165G>A								Homo sapiens mRNA; cDNA DKFZp313P036 (from clone DKFZp313P036).																		AAGAATTTCTCGTCTATTATG	0.383													8	7					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57100495	57100495	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:57100495C>T	uc002ekk.1	+	34	4516	c.4291C>T	c.(4291-4293)CAG>TAG	p.Q1431*	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_5'UTR|NLRC5_uc002ekr.1_Nonsense_Mutation_p.Q318*	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1431					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				ATTTCCTCGCCAGGAAGAGAA	0.637													9	19					0	0	1	0	0
CPNE2	221184	broad.mit.edu	37	16	57171134	57171134	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:57171134C>T	uc002eks.1	+	14	1471	c.1242C>T	c.(1240-1242)TCC>TCT	p.S414S	CPNE2_uc010cct.1_Silent_p.S440S|CPNE2_uc010ccu.1_Silent_p.S414S|CPNE2_uc002ekt.1_Intron	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	414	VWFA.									central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				CCAATTTCTCCCCCATCGTCA	0.612													12	25					0	0	1	0	0
CX3CL1	6376	broad.mit.edu	37	16	57416899	57416899	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:57416899C>T	uc002eli.2	+	3	1216	c.1149C>T	c.(1147-1149)ATC>ATT	p.I383I		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	383	Cytoplasmic (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						TTCGCTACATCCCCCGGAGCT	0.587													45	63					0	0	1	0	0
KATNB1	10300	broad.mit.edu	37	16	57785890	57785890	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:57785890C>T	uc002eml.1	+	8	929	c.555C>T	c.(553-555)TTC>TTT	p.F185F		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	185	Interaction with centrosomes.|Interaction with dynein (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				TGTCTGAGTTCCCTGGTCACA	0.637													9	16					0	0	1	0	0
CMTM1	113540	broad.mit.edu	37	16	66612856	66612856	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:66612856G>A	uc002epi.3	+	4	585	c.462G>A	c.(460-462)AAG>AAA	p.K154K	CMTM1_uc002epb.3_RNA|CMTM1_uc002epc.3_RNA|CMTM1_uc002epd.3_RNA|CMTM1_uc002epe.3_RNA|CMTM1_uc002epf.3_RNA|CMTM1_uc002epg.3_RNA|CMTM1_uc002eph.3_3'UTR|CMTM1_uc002epl.3_Silent_p.K107K|CMTM1_uc002epj.3_3'UTR|CMTM1_uc002epk.3_Silent_p.K101K|CMTM1_uc002epa.3_3'UTR|CMTM1_uc002epn.3_3'UTR|CMTM1_uc002epo.3_RNA|CMTM1_uc002epp.3_RNA|CMTM1_uc002epq.3_RNA|CMTM1_uc010cds.2_RNA|CMTM1_uc002epr.3_Silent_p.K271K|CMTM1_uc002epm.3_RNA|CMTM1_uc002eps.2_RNA|CMTM2_uc002ept.2_5'Flank|CMTM2_uc010cdu.2_5'Flank	NM_181269	NP_851786	Q8IZ96	CKLF1_HUMAN	chemokine-like factor superfamily 1 isoform 1	154					chemotaxis	extracellular space|integral to membrane	cytokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		CCCCCGCCAAGGACGCCTACC	0.612													27	28					0	0	1	0	0
RRAD	6236	broad.mit.edu	37	16	66956118	66956118	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:66956118C>T	uc002eqn.2	-	5	940	c.788G>A	c.(787-789)CGA>CAA	p.R263Q	RRAD_uc002eqo.2_Missense_Mutation_p.R263Q	NM_001128850	NP_001122322	P55042	RAD_HUMAN	Ras-related associated with diabetes	263					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		TGCTTGCCGTCGTGCGTTGGC	0.597													22	40					0	0	1	0	0
C16orf70	80262	broad.mit.edu	37	16	67165208	67165208	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:67165208T>C	uc002erc.2	+	5	335	c.251T>C	c.(250-252)TTG>TCG	p.L84S	C16orf70_uc002erd.2_Missense_Mutation_p.L84S|C16orf70_uc002ere.1_Missense_Mutation_p.L62S	NM_025187	NP_079463	Q9BSU1	CP070_HUMAN	lin-10	84										ovary(2)	2		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		GTATGTGATTTGACTAAAGTA	0.299													14	31					0	0	1	0	0
DDX28	55794	broad.mit.edu	37	16	68057103	68057103	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:68057103C>T	uc002evh.1	-	1	857	c.3G>A	c.(1-3)ATG>ATA	p.M1I	DUS2L_uc002evi.2_5'Flank|DUS2L_uc002evj.2_5'Flank|DUS2L_uc010vkk.1_5'Flank	NM_018380	NP_060850	Q9NUL7	DDX28_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28	1						mitochondrial nucleoid|nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0116)|Epithelial(162;0.0474)|all cancers(182;0.233)		GCGTTAGAGCCATGTTTCCCT	0.682													8	11					0	0	1	0	0
HAS3	3038	broad.mit.edu	37	16	69148556	69148556	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:69148556G>A	uc010cfh.2	+	4	1273	c.1049G>A	c.(1048-1050)TGG>TAG	p.W350*	HAS3_uc002ewk.2_Intron|HAS3_uc002ewl.2_Nonsense_Mutation_p.W350*	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	350	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		TACCTCCGGTGGCTCAACCAG	0.572													26	44					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70935003	70935003	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:70935003C>T	uc002ezr.2	-	53	9077	c.8949G>A	c.(8947-8949)CTG>CTA	p.L2983L		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2984										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TCCCCTGCATCAGGGATACAG	0.567													19	88					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70954610	70954610	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:70954610C>T	uc002ezr.2	-	46	7794	c.7666G>A	c.(7666-7668)GAA>AAA	p.E2556K		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2557										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ttcttcccttcgtggtcctcc	0.229													4	12					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71724592	71724592	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:71724592G>A	uc002fax.2	-	3	445	c.439C>T	c.(439-441)CGT>TGT	p.R147C	PHLPP2_uc010cgf.2_Missense_Mutation_p.R147C|PHLPP2_uc002fay.1_Missense_Mutation_p.R147C	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	147				R -> C (in Ref. 3; BX647823).		cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						CGATCCAAACGATCCATGTGG	0.418													15	19					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72198810	72198810	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:72198810C>T	uc002fcc.3	-	3	190	c.18G>A	c.(16-18)GGG>GGA	p.G6G	PMFBP1_uc002fcd.2_Silent_p.G6G|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_5'UTR	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	6										ovary(2)	2		Ovarian(137;0.179)				TGTCTCTCTCCCCCGCCTAGG	0.443													14	20					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72991358	72991358	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:72991358G>A	uc002fck.2	-	2	3360	c.2687C>T	c.(2686-2688)GCC>GTC	p.A896V	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	896					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CATGGGCCCGGCGGGATCCAG	0.547													42	64					0	0	1	0	0
Unknown	0	broad.mit.edu	37	16	74419244	74419244	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:74419244C>T	uc010vmt.1	+	2	72	c.71C>T	c.(70-72)TCT>TTT	p.S24F						RecName: Full=Nuclear pore complex-interacting protein-like 2; Flags: Precursor;																		TCCTAGGTGTCTTTCCTGAAG	0.289													36	117					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74719425	74719425	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:74719425G>A	uc002fdb.2	-	5	1220	c.779C>T	c.(778-780)CCC>CTC	p.P260L	MLKL_uc002fdc.2_Intron	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	260	Protein kinase.						ATP binding|protein binding|protein kinase activity			stomach(2)	2						CAGGATGTTGGGAGATTCGAA	0.353													10	18					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74729419	74729419	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:74729419G>A	uc002fdb.2	-	2	678	c.237C>T	c.(235-237)TTC>TTT	p.F79F	MLKL_uc002fdc.2_Silent_p.F79F	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	79							ATP binding|protein binding|protein kinase activity			stomach(2)	2						ATCTATTGCTGAACTTTTCTA	0.493													51	50					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401601	77401601	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:77401601C>T	uc002ffc.3	-	4	934	c.515G>A	c.(514-516)CGA>CAA	p.R172Q	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	172					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TTCATTTTTTCGTGTCCTTAT	0.463													14	21					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78064399	78064399	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:78064399G>A	uc002ffh.3	+	3	336	c.255G>A	c.(253-255)TTG>TTA	p.L85L		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	85	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						CAGAAGGTTTGAAGCATTTCC	0.438													14	37					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81925096	81925096	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:81925096C>T	uc002fgt.2	+	11	1039	c.887C>T	c.(886-888)TCA>TTA	p.S296L	PLCG2_uc010chg.1_Missense_Mutation_p.S296L	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	296					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TACCTGTTTTCACGAGAAAAC	0.502													21	30					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81972454	81972454	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:81972454C>T	uc002fgt.2	+	29	3399	c.3247C>T	c.(3247-3249)CCC>TCC	p.P1083S		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	1083	C2.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TATTGCCTGTCCCTTTGTAGA	0.527													13	26					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	82660706	82660706	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:82660706G>A	uc002fgx.2	+	1	129	c.9G>A	c.(7-9)CCG>CCA	p.P3P	CDH13_uc010chh.2_Silent_p.P3P|CDH13_uc010vns.1_Missense_Mutation_p.R15Q|CDH13_uc010vnt.1_5'UTR|CDH13_uc010vnu.1_Silent_p.P3P	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	3					adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		AAATGCAGCCGAGAACTCCGC	0.627													5	3					0	0	1	0	0
KLHL36	79786	broad.mit.edu	37	16	84690632	84690632	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:84690632C>T	uc002fig.2	+	3	360	c.219C>T	c.(217-219)TCC>TCT	p.S73S	KLHL36_uc010chl.2_Silent_p.S72S	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	73	BTB.									skin(2)	2						ACTTCAACTCCATGTTCACCA	0.627													15	24					0	0	1	0	0
IRF8	3394	broad.mit.edu	37	16	85952157	85952157	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:85952157G>A	uc002fjh.2	+	7	793	c.736G>A	c.(736-738)GGC>AGC	p.G246S	IRF8_uc010chp.2_Intron	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	246					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				TGGGCCCGAGGGCCTGGAGCT	0.736													16	16					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1577111	1577111	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:1577111G>A	uc002fte.2	-	22	3489	c.3375C>T	c.(3373-3375)ATC>ATT	p.I1125I		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1125						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TATAGCCAACGATGTTTTCAT	0.512													38	67					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1657526	1657526	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:1657526G>A	uc002ftk.1	+	10	1251	c.1174G>A	c.(1174-1176)GAG>AAG	p.E392K	SERPINF2_uc010vqr.1_Missense_Mutation_p.E328K	NM_000934	NP_000925	P08697	A2AP_HUMAN	alpha-2-antiplasmin isoform a precursor	392					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	GGTCGGCGTGGAGGCGGCGGC	0.652													41	69					0	0	1	0	0
OR1A1	8383	broad.mit.edu	37	17	3119431	3119431	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:3119431G>A	uc010vrc.1	+	1	517	c.517G>A	c.(517-519)GAA>AAA	p.E173K		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGGCAACCAGGAAGTGGCCAA	0.488													30	69					0	0	1	0	0
OR3A1	4994	broad.mit.edu	37	17	3195299	3195299	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:3195299G>A	uc002fvh.1	-	1	578	c.578C>T	c.(577-579)TCC>TTC	p.S193F		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						TTGGGTGCTGGAGCAGGAGAG	0.527													45	71					0	0	1	0	0
P2RX5	5026	broad.mit.edu	37	17	3595052	3595052	+	Silent	SNP	G	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:3595052G>C	uc002fwi.2	-	2	458	c.174C>G	c.(172-174)GTC>GTG	p.V58V	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Silent_p.V58V|P2RX5_uc010vrx.1_Silent_p.V22V|P2RX5_uc002fwj.2_Silent_p.V58V|P2RX5_uc002fwk.2_Silent_p.V58V|P2RX5_uc002fwl.2_Silent_p.V58V|P2RX5_uc002fwm.1_Silent_p.V58V	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	58	Extracellular (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GGGAGGTGTCGACGTCTTGGT	0.602													46	79					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5462795	5462795	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:5462795G>A	uc002gci.2	-	4	1776	c.1221C>T	c.(1219-1221)TTC>TTT	p.F407F	NLRP1_uc002gcg.1_Silent_p.F407F|NLRP1_uc002gck.2_Silent_p.F407F|NLRP1_uc002gcj.2_Silent_p.F407F|NLRP1_uc002gcl.2_Silent_p.F407F|NLRP1_uc002gch.3_Silent_p.F407F|NLRP1_uc010clh.2_Silent_p.F407F	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	407	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				CATCGAGGATGAAGAGCAGCC	0.592													19	24					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5463109	5463109	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:5463109A>T	uc002gci.2	-	4	1462	c.907T>A	c.(907-909)TAT>AAT	p.Y303N	NLRP1_uc002gcg.1_Missense_Mutation_p.Y303N|NLRP1_uc002gck.2_Missense_Mutation_p.Y303N|NLRP1_uc002gcj.2_Missense_Mutation_p.Y303N|NLRP1_uc002gcl.2_Missense_Mutation_p.Y303N|NLRP1_uc002gch.3_Missense_Mutation_p.Y303N|NLRP1_uc010clh.2_Missense_Mutation_p.Y303N	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	303					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				TCCTCCACATAATCAGGCCAG	0.473													105	115					0	0	1	0	0
KIAA0753	9851	broad.mit.edu	37	17	6493866	6493866	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:6493866G>A	uc002gde.3	-	17	2884	c.2525C>T	c.(2524-2526)GCC>GTC	p.A842V	KIAA0753_uc010vtd.1_Missense_Mutation_p.A298V|KIAA0753_uc010clo.2_Missense_Mutation_p.A543V|KIAA0753_uc010vte.1_Missense_Mutation_p.A543V	NM_014804	NP_055619	Q2KHM9	K0753_HUMAN	hypothetical protein LOC9851	842						centrosome					0				COAD - Colon adenocarcinoma(228;0.157)		GATGTTCACGGCTGGATCCTT	0.413													25	22					0	0	1	0	0
KCTD11	147040	broad.mit.edu	37	17	7256761	7256761	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:7256761C>T	uc002gge.3	+	1	1554	c.500C>T	c.(499-501)CCC>CTC	p.P167L	TMEM95_uc002ggf.1_5'Flank|TMEM95_uc002ggg.1_5'Flank|TMEM95_uc002ggh.1_5'Flank	NM_001002914	NP_001002914	Q693B1	KCD11_HUMAN	potassium channel tetramerisation domain	167					cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Prostate(122;0.157)				GTGGAACTCCCCGAGGTGGAG	0.677													16	21					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7636504	7636504	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:7636504T>C	uc002giu.1	+	4	513	c.499T>C	c.(499-501)TAT>CAT	p.Y167H	DNAH2_uc002git.2_Missense_Mutation_p.Y167H|DNAH2_uc010vuk.1_Missense_Mutation_p.Y167H	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	167	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCGGGGCCCCTATATCCCGGC	0.552													3	106					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7707764	7707764	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:7707764G>A	uc002giu.1	+	58	9177	c.9163G>A	c.(9163-9165)GAG>AAG	p.E3055K	DNAH2_uc010cnm.1_Missense_Mutation_p.E32K	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3055	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCAGAAGCGGGAGGCAGATGA	0.612													12	17					0	0	1	0	0
C17orf68	80169	broad.mit.edu	37	17	8141428	8141428	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:8141428G>A	uc002gkq.3	-	4	627	c.568C>T	c.(568-570)CCT>TCT	p.P190S	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	190					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						ATGGTCAAAGGAAACACTGGC	0.577													37	40					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10312759	10312759	+	Silent	SNP	G	A	A	rs144464113		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:10312759G>A	uc002gmm.2	-	16	1829	c.1734C>T	c.(1732-1734)GCC>GCT	p.A578A	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	578	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GAGAGAAGTGGGCCTCAGCCT	0.522									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				37	48					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10364285	10364285	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:10364285C>T	uc002gmn.2	-	12	1206	c.1095G>A	c.(1093-1095)ATG>ATA	p.M365I	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	365	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GCTTGAATTTCATGTTCCCAT	0.483													31	66					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10408168	10408168	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:10408168G>A	uc002gmo.2	-	22	2744	c.2650C>T	c.(2650-2652)CTG>TTG	p.L884L	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	884	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCTTGCATCAGAGTAACCATT	0.428													23	39					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10439889	10439889	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:10439889C>T	uc010coi.2	-	17	2060	c.1932G>A	c.(1930-1932)AAG>AAA	p.K644K	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.K644K|MYH2_uc010coj.2_Silent_p.K644K	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	644	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AGCCCTTCTTCTTACCACCTT	0.403													9	15					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10446432	10446432	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:10446432G>A	uc010coi.2	-	9	916	c.788C>T	c.(787-789)TCT>TTT	p.S263F	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.S263F|MYH2_uc010coj.2_Missense_Mutation_p.S263F	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	263	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AATATCAGCAGATGCCAGTTT	0.294													34	54					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10447033	10447033	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:10447033G>A	uc010coi.2	-	8	864	c.736C>T	c.(736-738)CGC>TGC	p.R246C	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R246C|MYH2_uc010coj.2_Missense_Mutation_p.R246C	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	246	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTTACAAAGCGAGAGGAGTTG	0.448													18	32					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11651075	11651075	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:11651075G>A	uc002gne.2	+	32	6670	c.6602G>A	c.(6601-6603)TGG>TAG	p.W2201*	DNAH9_uc010coo.2_Nonsense_Mutation_p.W1495*	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2201	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACAGGAGAATGGAAGGATGGT	0.512													24	26					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12618858	12618858	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:12618858C>T	uc002gnn.2	+	3	443	c.144C>T	c.(142-144)TTC>TTT	p.F48F	MYOCD_uc002gno.2_Silent_p.F48F	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	48					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CAGCTGAATTCCATGAGCAAA	0.413													11	19					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12626277	12626277	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:12626277G>A	uc002gnn.2	+	5	666	c.367G>A	c.(367-369)GAA>AAA	p.E123K	MYOCD_uc002gno.2_Missense_Mutation_p.E123K|MYOCD_uc002gnp.1_Missense_Mutation_p.E27K	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	123	RPEL 3.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GGAGCTGGTGGAAAAAAACAT	0.473													49	61					0	0	1	0	0
TNFRSF13B	23495	broad.mit.edu	37	17	16852251	16852251	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:16852251G>A	uc002gqs.1	-	3	259	c.246C>T	c.(244-246)CTC>CTT	p.L82L	TNFRSF13B_uc010vwt.1_RNA|TNFRSF13B_uc002gqt.1_Silent_p.L36L|TNFRSF13B_uc010vwu.1_Silent_p.L82L	NM_012452	NP_036584	O14836	TR13B_HUMAN	tumor necrosis factor receptor 13B	82	Extracellular (Potential).|TNFR-Cys 2.				cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity			kidney(2)	2						AGTCCCTCAGGAGATGGTCAT	0.527									IgA_Deficiency_Selective				35	44					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18054713	18054713	+	Silent	SNP	A	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:18054713A>C	uc010vxh.1	+	39	7997	c.7659A>C	c.(7657-7659)TCA>TCC	p.S2553S	MYO15A_uc010vxi.1_5'Flank|MYO15A_uc010vxj.1_5'Flank|MYO15A_uc010vxk.1_5'Flank	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2553	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CCACAGCTTCACCCTCCCCAG	0.617													17	33					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18923089	18923089	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:18923089C>T	uc002guu.1	+	13	1515	c.1474C>T	c.(1474-1476)CTG>TTG	p.L492L	SLC5A10_uc002gur.1_Silent_p.L462L|SLC5A10_uc002gut.1_Silent_p.L508L|SLC5A10_uc002guv.1_Silent_p.L465L|SLC5A10_uc010vyl.1_Silent_p.L456L	NM_001042450	NP_001035915	A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/glucose	492	Helical; (Potential).				sodium ion transport|transmembrane transport	integral to membrane	transporter activity			ovary(1)	1						CCTGGAATTCCTGAACCCAGC	0.682													6	9					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18923740	18923740	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:18923740C>T	uc002guu.1	+	15	1828	c.1787C>T	c.(1786-1788)GCC>GTC	p.A596V	SLC5A10_uc002gur.1_Missense_Mutation_p.A566V|SLC5A10_uc002gut.1_Missense_Mutation_p.A612V|SLC5A10_uc002guv.1_Missense_Mutation_p.A569V|SLC5A10_uc010vyl.1_Missense_Mutation_p.A560V	NM_001042450	NP_001035915	A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/glucose	596	Helical; (Potential).				sodium ion transport|transmembrane transport	integral to membrane	transporter activity			ovary(1)	1						GCCTACTTCGCCTGACACTGC	0.562													12	21					0	0	1	0	0
Unknown	0	broad.mit.edu	37	17	19015619	19015619	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:19015619C>T	uc010vym.1	-	1		c.38G>A								DL492381																		GCCGTCACCGCTGAAACAGGA	0.547													5	45					0	0	1	0	0
MAPK7	5598	broad.mit.edu	37	17	19284811	19284811	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:19284811C>T	uc002gvn.2	+	4	1675	c.1289C>T	c.(1288-1290)GCC>GTC	p.A430V	MAPK7_uc002gvo.2_Missense_Mutation_p.A291V|MAPK7_uc002gvq.2_Missense_Mutation_p.A430V|MAPK7_uc002gvp.2_Missense_Mutation_p.A430V	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	430	May not be required for kinase activity; required to stimulate MEF2C activity (By similarity).|Pro-rich.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					GGGGACTGTGCCATGGAGTCT	0.627													27	41					0	0	1	0	0
Unknown	0	broad.mit.edu	37	17	25752543	25752543	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:25752543C>T	uc002gzg.2	+	9		c.1378C>T			uc002gzi.1_5'Flank					Homo sapiens similar to ubiquitin specific protease 6, mRNA (cDNA clone IMAGE:5168266), with apparent retained intron.																		GGCTCCAAGACCATCAGGAGC	0.552													44	62					0	0	1	0	0
PIGS	94005	broad.mit.edu	37	17	26881493	26881493	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:26881493G>A	uc002hbo.2	-	12	1786	c.1413C>T	c.(1411-1413)GCC>GCT	p.A471A	UNC119_uc002hbk.2_5'Flank|UNC119_uc002hbm.2_5'Flank|PIGS_uc002hbn.2_Silent_p.A463A|PIGS_uc010wap.1_Silent_p.A410A	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	471	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					ACTTCTGGACGGCAGCTACAG	0.557													32	76					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27028485	27028485	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:27028485G>A	uc002hby.2	+	37	5113	c.5023G>A	c.(5023-5025)GGA>AGA	p.G1675R	SUPT6H_uc010crt.2_Missense_Mutation_p.G1675R	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1675					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					CATCGACTGGGGAAAAATGGC	0.567													15	38					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29562741	29562741	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:29562741T>A	uc002hgg.2	+	28	4154	c.3821T>A	c.(3820-3822)CTC>CAC	p.L1274H	NF1_uc002hgh.2_Missense_Mutation_p.L1274H|NF1_uc010csn.1_Missense_Mutation_p.L1134H|NF1_uc002hgi.1_Missense_Mutation_p.L307H	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1274	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATGCAGACTCTCTTCCGAGGC	0.408			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			65	60					0	0	1	0	0
ACCN1	40	broad.mit.edu	37	17	31352993	31352993	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:31352993G>A	uc002hhu.2	-	5	1267	c.993C>T	c.(991-993)GCC>GCT	p.A331A	ACCN1_uc002hht.2_Silent_p.A382A	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	331	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	TACAAAAAGGGGCATCCCCTG	0.562													11	23					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32964901	32964901	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:32964901G>A	uc002hif.2	+	10	2933	c.2605G>A	c.(2605-2607)GAA>AAA	p.E869K		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	869	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CAACCCGCTGGAAACCGTGCC	0.701													11	11					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33772687	33772687	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:33772687G>A	uc002hjk.1	-	1	343	c.13C>T	c.(13-15)CAC>TAC	p.H5Y	SLFN13_uc010wch.1_Missense_Mutation_p.H5Y|SLFN13_uc002hjl.2_Missense_Mutation_p.H5Y|SLFN13_uc010ctt.2_Missense_Mutation_p.H5Y|SLFN13_uc002hjm.2_5'UTR	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	5						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AGGGAGCAGTGATTTGCCTCC	0.363													16	20					0	0	1	0	0
TAF15	8148	broad.mit.edu	37	17	34171101	34171101	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:34171101C>T	uc002hkd.2	+	13	1113	c.1027C>T	c.(1027-1029)CGT>TGT	p.R343C	TAF15_uc010ctw.1_RNA|TAF15_uc002hkc.2_Missense_Mutation_p.R340C	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	343	Arg/Gly-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		ATATAGAGGTCGTGGAGGCTT	0.488			T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								46	77					0	0	1	0	0
C17orf66	256957	broad.mit.edu	37	17	34192307	34192307	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:34192307C>T	uc002hke.1	-	3	381	c.232G>A	c.(232-234)GAG>AAG	p.E78K	C17orf66_uc010wck.1_RNA|C17orf66_uc010wcl.1_Missense_Mutation_p.E78K|C17orf66_uc010wcm.1_Missense_Mutation_p.E44K	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957	78							binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GTGTAGATCTCAGGTTTCTTG	0.517													18	24					0	0	1	0	0
CCL16	6360	broad.mit.edu	37	17	34308409	34308409	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:34308409G>A	uc002hkl.2	-	1	115	c.48C>T	c.(46-48)ATC>ATT	p.I16I	CCL16_uc002hkm.2_RNA	NM_004590	NP_004581	O15467	CCL16_HUMAN	small inducible cytokine A16 precursor	16					cell-cell signaling|immune response|inflammatory response	extracellular space	chemoattractant activity|chemokine activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCGAAGTAATGATAAGGATGA	0.557													11	12					0	0	1	0	0
SOCS7	30837	broad.mit.edu	37	17	36521280	36521280	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:36521280C>T	uc002hqa.2	+	4	1171	c.1048C>T	c.(1048-1050)CCC>TCC	p.P350S	SOCS7_uc010cvl.2_Intron|SOCS7_uc002hqb.2_RNA	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	350	Mediates interaction with SORBS3.|Poly-Pro.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					GCCTCCTCCACCCCATGCCCC	0.488													18	31					0	0	1	0	0
GRB7	2886	broad.mit.edu	37	17	37901701	37901701	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:37901701G>A	uc002hsr.2	+	11	1369	c.1119G>A	c.(1117-1119)GTG>GTA	p.V373V	GRB7_uc002hss.2_Silent_p.V373V|GRB7_uc010cwc.2_Silent_p.V373V|GRB7_uc002hst.2_Silent_p.V373V	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	373					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			ATACCCTGGTGGCCATGGACT	0.622													26	27					0	0	1	0	0
KRTAP1-1	81851	broad.mit.edu	37	17	39197478	39197478	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:39197478G>A	uc002hvw.1	-	1	236	c.172C>T	c.(172-174)CCT>TCT	p.P58S		NM_030967	NP_112229	Q07627	KRA11_HUMAN	keratin associated protein 1-1	58			Missing (in allele KAP1.7).|PSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQT SFCGFP -> R (in allele KAP1.6).			extracellular region|keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GAGAAGCTAGGAAATCCACAG	0.602													48	81					0	0	1	0	0
KRT33A	3883	broad.mit.edu	37	17	39505678	39505678	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:39505678G>A	uc002hwk.1	-	2	388	c.351C>T	c.(349-351)ATC>ATT	p.I117I		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	117	Rod.|Coil 1B.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				TGCTGCACAGGATCTAGAAGG	0.498													17	16					0	0	1	0	0
KRT9	3857	broad.mit.edu	37	17	39723556	39723556	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:39723556C>T	uc002hxe.3	-	7	1907	c.1841G>A	c.(1840-1842)GGA>GAA	p.G614E	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	614	Tail.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				gcttcctcctccgtagccgcc	0.194													19	28					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40322138	40322138	+	Silent	SNP	C	T	T	rs146054199		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:40322138C>T	uc002hzb.2	-	8	1710	c.1377G>A	c.(1375-1377)ACG>ACA	p.T459T		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	459	Extracellular (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTATGAGCATCGTGCAGATGG	0.498													21	38					0	0	1	0	0
NAGLU	4669	broad.mit.edu	37	17	40693178	40693178	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:40693178C>T	uc002hzv.2	+	5	1315	c.975C>T	c.(973-975)TCC>TCT	p.S325S		NM_000263	NP_000254	P54802	ANAG_HUMAN	alpha-N-acetylglucosaminidase precursor	325						lysosome	alpha-N-acetylglucosaminidase activity				0		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	CAGAGCCCTCCTACCTTGCCG	0.587													28	43					0	0	1	0	0
C17orf104	284071	broad.mit.edu	37	17	42745038	42745039	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:42745038_42745039GG>AA	uc010czv.2	+	5	1759_1760	c.1759_1760GG>AA	c.(1759-1761)GGA>AAA	p.G587K	C17orf104_uc002igy.1_Missense_Mutation_p.G421K|C17orf104_uc002igz.3_Missense_Mutation_p.G421K|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Missense_Mutation_p.G421K	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	587										central_nervous_system(1)	1						GCAGCCAAATGGATTTTGTGAT	0.351													9	21					0	0	1	0	0
C17orf57	124989	broad.mit.edu	37	17	45452298	45452298	+	Silent	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:45452298T>A	uc002iln.2	+	12	1749	c.1338T>A	c.(1336-1338)GTT>GTA	p.V446V	C17orf57_uc002ilm.2_Silent_p.V350V|C17orf57_uc002ill.1_Silent_p.V202V|C17orf57_uc010daz.1_Silent_p.V398V	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	446							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						AAAAACAGGTTTCGTCTACGG	0.368													6	13					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48741448	48741448	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:48741448C>T	uc002isl.2	+	10	1394	c.1314C>T	c.(1312-1314)ATC>ATT	p.I438I	ABCC3_uc002isk.3_Silent_p.I438I|ABCC3_uc002ism.2_Missense_Mutation_p.P151S	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	438	ABC transmembrane type-1 1.|Helical; Name=8; (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TGCAGATCATCCTGGCGATCT	0.552													44	37					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900577	51900578	+	Nonsense_Mutation	DNP	GG	AT	AT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:51900577_51900578GG>AT	uc002iua.2	+	1	339_340	c.183_184GG>AT	c.(181-186)GTGGAG>GTATAG	p.E62*		NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	62					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TAGAGTGGGTGGAGAAAGCAGT	0.554													45	62					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901311	51901311	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:51901311G>A	uc002iua.2	+	1	1073	c.917G>A	c.(916-918)GGA>GAA	p.G306E	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	306	ATP (By similarity).|Kinesin-motor.			G -> R (in Ref. 1; AAK20830).	blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GGGCAGACGGGAAGTGGGAAG	0.552													20	41					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54543772	54543772	+	Missense_Mutation	SNP	G	A	A	rs149688029	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:54543772G>A	uc002iun.1	+	14	1657	c.1622G>A	c.(1621-1623)CGA>CAA	p.R541Q		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	541										large_intestine(1)|ovary(1)	2						ATTAAAGATCGACATGGAAAC	0.403													20	29					0	0	1	0	0
BCAS3	54828	broad.mit.edu	37	17	59112065	59112065	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:59112065C>T	uc002iyv.3	+	18	1830	c.1721C>T	c.(1720-1722)TCG>TTG	p.S574L	BCAS3_uc010wow.1_Missense_Mutation_p.S346L|BCAS3_uc002iyu.3_Missense_Mutation_p.S559L|BCAS3_uc002iyw.3_Missense_Mutation_p.S555L|BCAS3_uc002iyy.3_Missense_Mutation_p.S330L|BCAS3_uc002iyz.3_Missense_Mutation_p.S128L|BCAS3_uc002iza.3_Missense_Mutation_p.S113L	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	574						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			CCCAGCAAATCGATGGGCGGA	0.348													22	33					0	0	1	0	0
EFCAB3	146779	broad.mit.edu	37	17	60484458	60484458	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:60484458G>A	uc002izu.1	+	8	830	c.752G>A	c.(751-753)GGG>GAG	p.G251E	EFCAB3_uc010wpc.1_Missense_Mutation_p.G303E	NM_173503	NP_775774	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3 isoform b	251							calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			AATGTGGATGGGGTGGTGATG	0.358													30	37					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62022171	62022171	+	Splice_Site	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:62022171C>T	uc002jds.1	-	21	3852	c.3775_splice	c.e21-1	p.K1259_splice		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha						muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GCTCCTCCTTCTGTGGGAGCC	0.592													11	12					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62036697	62036697	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:62036697G>A	uc002jds.1	-	12	2024	c.1947C>T	c.(1945-1947)ATC>ATT	p.I649I		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	649	Helical; Name=S3 of repeat II; (Potential).|II.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TGAGGGTGACGATGATGCTGT	0.552													30	25					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65907666	65907666	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:65907666T>G	uc002jgf.2	+	11	3727	c.3666T>G	c.(3664-3666)AGT>AGG	p.S1222R	BPTF_uc002jge.2_Missense_Mutation_p.S1348R	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1348					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			AACTAGCCAGTGCAGATGATA	0.388													15	21					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67077236	67077236	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:67077236A>G	uc002jhw.1	-	37	4842	c.4667T>C	c.(4666-4668)CTA>CCA	p.L1556P		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1556					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					GGTCTGTGATAGAGGGTAAAC	0.368													47	60					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232316	71232316	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:71232316C>T	uc002jjm.3	+	3	889	c.695C>T	c.(694-696)CCA>CTA	p.P232L	C17orf80_uc010wqu.1_Missense_Mutation_p.P232L|C17orf80_uc010dfj.2_Missense_Mutation_p.P232L|C17orf80_uc002jjk.1_Missense_Mutation_p.P232L|C17orf80_uc002jjl.3_Missense_Mutation_p.P232L	NM_017941	NP_060411	Q9BSJ5	CQ080_HUMAN	lung cancer-related protein 8 isoform a	232	Extracellular (Potential).					integral to membrane				skin(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			CATATTTCTCCAAAGAATGTC	0.403													19	42					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71335036	71335036	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:71335036G>A	uc010dfm.2	-	45	6209	c.6209C>T	c.(6208-6210)GCC>GTC	p.A2070V	SDK2_uc002jjt.3_Missense_Mutation_p.A1210V	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	2070	Cytoplasmic (Potential).				cell adhesion	integral to membrane				ovary(2)	2						AAAGGAGTGGGCCTTCTGGTG	0.582													18	34					0	0	1	0	0
CD300E	342510	broad.mit.edu	37	17	72613293	72613293	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:72613293C>T	uc002jlb.1	-	2	393	c.352G>A	c.(352-354)GAT>AAT	p.D118N		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	118	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TCCGAGGGATCGCGTGACCAT	0.537													23	54					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73089822	73089822	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:73089822C>T	uc002jmr.2	+	3	463	c.91C>T	c.(91-93)CCC>TCC	p.P31S	SLC16A5_uc002jms.1_Missense_Mutation_p.P31S|SLC16A5_uc002jmt.2_Missense_Mutation_p.P31S|SLC16A5_uc002jmu.2_Missense_Mutation_p.P31S|SLC16A5_uc010wrt.1_Missense_Mutation_p.P71S	NM_004695	NP_004686	O15375	MOT6_HUMAN	solute carrier family 16, member 5	31	Helical; (Potential).				organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	CCTGGGCTTCCCCACGTGTAT	0.632													41	39					0	0	1	0	0
RECQL5	9400	broad.mit.edu	37	17	73659055	73659055	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:73659055G>A	uc010dgl.2	-	4	431	c.275C>T	c.(274-276)ACC>ATC	p.T92I	RECQL5_uc010dgk.2_Missense_Mutation_p.T65I|RECQL5_uc002jpb.1_Missense_Mutation_p.T92I|RECQL5_uc002joz.3_Missense_Mutation_p.T92I|RECQL5_uc002jpa.3_Missense_Mutation_p.T92I	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	92	Helicase ATP-binding.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TACCTTTAGGGTTAGCAAGTG	0.512								Other_identified_genes_with_known_or_suspected_DNA_repair_function					66	82					0	0	1	0	0
ZACN	353174	broad.mit.edu	37	17	74077799	74077799	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:74077799G>A	uc002jqn.2	+	7	926	c.843G>A	c.(841-843)CAG>CAA	p.Q281Q	ZACN_uc002jqo.2_RNA|ZACN_uc010dgu.2_RNA|EXOC7_uc002jqp.1_3'UTR|EXOC7_uc010dgv.1_3'UTR|EXOC7_uc002jqs.2_3'UTR|EXOC7_uc002jqq.2_3'UTR|EXOC7_uc010wsw.1_3'UTR|EXOC7_uc010wsx.1_3'UTR|EXOC7_uc002jqr.2_3'UTR|EXOC7_uc010wsv.1_3'UTR	NM_180990	NP_851321	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	281	Helical; Name=2; (Potential).|Leu-rich.				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity				0						CCCTGGTGCAGGCCCTGCCCA	0.632													26	30					0	0	1	0	0
FAM100B	283991	broad.mit.edu	37	17	74261619	74261619	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:74261619G>A	uc010wsy.1	+	1	334	c.33G>A	c.(31-33)CAG>CAA	p.Q11Q		NM_182565	NP_872371	Q8IYN6	F100B_HUMAN	hypothetical protein LOC283991	11										central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			TGCGGCACCAGGTCATGATCA	0.438													5	10					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76498990	76498990	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:76498990C>T	uc010wtu.1	-	6	1112	c.935G>A	c.(934-936)TGG>TAG	p.W312*	uc002jvt.1_RNA					full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTCCAGGATCCACTGCTCCCT	0.627													14	23					0	0	1	0	0
GAA	2548	broad.mit.edu	37	17	78092030	78092030	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:78092030C>T	uc002jxo.2	+	19	2702	c.2520C>T	c.(2518-2520)CCC>CCT	p.P840P	GAA_uc002jxp.2_Silent_p.P840P|GAA_uc002jxq.2_Silent_p.P840P	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	840					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GCCAGCAGCCCATGGCCCTGG	0.662													15	50					0	0	1	0	0
C17orf56	146705	broad.mit.edu	37	17	79207446	79207446	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:79207446G>A	uc002jzu.1	-	6	468	c.446C>T	c.(445-447)CCT>CTT	p.P149L	C17orf56_uc002jzr.1_5'Flank|C17orf56_uc002jzs.1_5'UTR|C17orf56_uc002jzt.1_5'UTR|C17orf56_uc002jzv.1_5'UTR|uc002jzw.1_Intron	NM_144679	NP_653280	Q96N21	CQ056_HUMAN	hypothetical protein LOC146705	149						integral to membrane					0	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			ACCTGTGGCAGGCGGGGTCCC	0.667													11	11					0	0	1	0	0
FSCN2	25794	broad.mit.edu	37	17	79496291	79496291	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:79496291G>A	uc010wup.1	+	1	875	c.734G>A	c.(733-735)CGA>CAA	p.R245Q	FSCN2_uc010wuo.1_Missense_Mutation_p.R245Q	NM_012418	NP_036550	O14926	FSCN2_HUMAN	fascin 2 isoform 1	245					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging				0	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CGAAACACGCGACCTGGCAAG	0.647													4	14					0	0	1	0	0
THOC4	10189	broad.mit.edu	37	17	79847154	79847154	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:79847154G>A	uc002kbu.2	-	3	448	c.442C>T	c.(442-444)CGC>TGC	p.R148C	ANAPC11_uc002kbv.1_5'Flank|ANAPC11_uc002kbw.1_5'Flank|ANAPC11_uc002kbx.1_5'Flank|ANAPC11_uc002kby.1_5'Flank|ANAPC11_uc002kbz.1_5'Flank|ANAPC11_uc002kca.1_5'Flank|ANAPC11_uc002kcb.1_5'Flank|ANAPC11_uc002kcc.1_5'Flank	NM_005782	NP_005773	Q86V81	THOC4_HUMAN	THO complex 4	141	RRM.|Ala/Arg/Gly-rich.				intronless viral mRNA export from host nucleus|mRNA 3'-end processing|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear speck|transcription export complex	nucleotide binding|protein binding|RNA binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CGACCAGAGCGATCATAGTGC	0.532													37	54					0	0	1	0	0
PYCR1	5831	broad.mit.edu	37	17	79892830	79892830	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:79892830G>A	uc002kcr.1	-	4	790	c.512C>T	c.(511-513)ACG>ATG	p.T171M	PYCR1_uc002kcq.1_Missense_Mutation_p.T171M|PYCR1_uc002kcp.2_Missense_Mutation_p.T171M|PYCR1_uc002kcs.1_Missense_Mutation_p.T171M|PYCR1_uc010wvd.1_Missense_Mutation_p.T198M|PYCR1_uc002kct.1_Missense_Mutation_p.T171M|PYCR1_uc002kcu.1_Missense_Mutation_p.T171M|PYCR1_uc010wve.1_Missense_Mutation_p.T123M	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	171					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	ACTGAGCCCCGTGACGGCATC	0.697													12	19					0	0	1	0	0
ZNF750	79755	broad.mit.edu	37	17	80788706	80788706	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr17:80788706G>A	uc002kga.2	-	3	1795	c.1484C>T	c.(1483-1485)TCT>TTT	p.S495F	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	495						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CGAGACGAGAGAGGCGCTTCC	0.572													25	39					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887844	9887844	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:9887844G>A	uc002koi.3	+	2	1817	c.1368G>A	c.(1366-1368)AAG>AAA	p.K456K	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Silent_p.K389K	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	456	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						TCCTGAGCAAGGAGGACTTTG	0.567													16	15					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13068955	13068955	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:13068955G>A	uc010xac.1	+	25	5007	c.4927G>A	c.(4927-4929)GGA>AGA	p.G1643R	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.G1168R|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.G65R|CEP192_uc002krw.2_5'Flank	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1643										ovary(4)|pancreas(1)	5						AGCAAGAGCAGGAATAGCTAG	0.488													34	52					0	0	1	0	0
MC2R	4158	broad.mit.edu	37	18	13884922	13884922	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:13884922A>G	uc002ksp.1	-	2	773	c.596T>C	c.(595-597)CTG>CCG	p.L199P		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	199	Helical; Name=5; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	GGATCGAGCCAGCAGGAACAT	0.562													23	29					0	0	1	0	0
C18orf45	85019	broad.mit.edu	37	18	20889667	20889667	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:20889667G>A	uc002kuf.2	-	14	916	c.807C>T	c.(805-807)ATC>ATT	p.I269I	C18orf45_uc010xaq.1_RNA|C18orf45_uc010xar.1_RNA|C18orf45_uc002kug.2_RNA|C18orf45_uc002kuh.2_RNA|C18orf45_uc002kue.2_RNA	NM_032933	NP_116322	Q24JQ0	CR045_HUMAN	hypothetical protein LOC85019	269	Helical; (Potential).					integral to membrane					0	all_cancers(21;0.000238)|all_epithelial(16;5.29e-06)|Lung NSC(20;0.00925)|Colorectal(14;0.0202)|all_lung(20;0.0255)|Ovarian(20;0.127)					CACTGGTCAGGATCGCATCAA	0.398													20	39					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21136463	21136463	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:21136463G>A	uc002kum.3	-	8	1344	c.1070C>T	c.(1069-1071)TCG>TTG	p.S357L	NPC1_uc010xaz.1_Missense_Mutation_p.S158L|NPC1_uc010xba.1_Missense_Mutation_p.S202L	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	357	Helical; (Potential).				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GAAGACCAGCGAGAAGAAAAT	0.587													14	16					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21399878	21399878	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:21399878G>A	uc002kuq.2	+	19	2307	c.2221G>A	c.(2221-2223)GGG>AGG	p.G741R	LAMA3_uc002kur.2_Missense_Mutation_p.G741R	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	741					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACACCTAATGGGAGAGACCT	0.423													13	19					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21489216	21489216	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:21489216G>A	uc002kuq.2	+	55	7201	c.7115G>A	c.(7114-7116)AGA>AAA	p.R2372K	LAMA3_uc002kur.2_Missense_Mutation_p.R2316K|LAMA3_uc002kus.3_Missense_Mutation_p.R763K|LAMA3_uc002kut.3_Missense_Mutation_p.R707K	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2372	Domain II and I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AACATGGACAGAATACGAGAA	0.453													30	37					0	0	1	0	0
HRH4	59340	broad.mit.edu	37	18	22056887	22056887	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:22056887A>G	uc002kvi.2	+	3	634	c.534A>G	c.(532-534)ACA>ACG	p.T178T	HRH4_uc010xbd.1_3'UTR|HRH4_uc010dlx.2_Silent_p.T90T	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	178	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TTGCCATCACATCATTCTTGG	0.413													46	62					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28672216	28672216	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:28672216C>T	uc002kwl.3	-	3	656	c.202G>A	c.(202-204)GAT>AAT	p.D68N	DSC2_uc002kwk.3_Missense_Mutation_p.D68N|DSC2_uc010xbo.1_Missense_Mutation_p.D68N	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	68					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			AAGTCAGGATCACTTGAATGA	0.333													12	27					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28725590	28725590	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:28725590G>A	uc002kwn.2	-	7	1185	c.923C>T	c.(922-924)CCT>CTT	p.P308L	DSC1_uc002kwm.2_Missense_Mutation_p.P308L	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	308	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ATCCAGAAAAGGTGTAGTTGT	0.378													24	47					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28966653	28966653	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:28966653G>A	uc002kwq.2	+	3	222	c.87G>A	c.(85-87)GTG>GTA	p.V29V	DSG4_uc002kwr.2_Silent_p.V29V	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	29					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGCTTAAGGTGAAGGAATTTG	0.388													28	24					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29054225	29054225	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:29054225G>A	uc002kws.2	+	15	2352	c.2243G>A	c.(2242-2244)GGA>GAA	p.G748E	DSG3_uc002kwt.2_Missense_Mutation_p.G30E	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	748	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCTGCTTCAGGATTCGGAGCA	0.532													16	21					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29056140	29056140	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:29056140C>T	uc002kws.2	+	16	3026	c.2917C>T	c.(2917-2919)CCT>TCT	p.P973S	DSG3_uc002kwt.2_Missense_Mutation_p.P255S	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	973	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTCCAGTGTTCCTGGCAACCT	0.498													48	59					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29102103	29102103	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:29102103C>T	uc002kwu.3	+	6	769	c.581C>T	c.(580-582)TCG>TTG	p.S194L		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	194	Extracellular (Potential).|Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			ACCCTGAATTCGAAAATTTCC	0.363													13	24					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31319118	31319118	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:31319118C>T	uc010dmg.1	+	11	1805	c.1750C>T	c.(1750-1752)CCA>TCA	p.P584S	ASXL3_uc002kxq.2_Missense_Mutation_p.P291S	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AGGCCAGTTTCCAAATGAAGG	0.433													7	7					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325730	31325730	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:31325730G>A	uc010dmg.1	+	12	5973	c.5918G>A	c.(5917-5919)GGA>GAA	p.G1973E	ASXL3_uc002kxq.2_Missense_Mutation_p.G1680E	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1973					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AAGGGATTGGGAGAGGTTAGT	0.517													43	62					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31326539	31326540	+	Missense_Mutation	DNP	GC	TT	TT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:31326539_31326540GC>TT	uc010dmg.1	+	12	6782_6783	c.6727_6728GC>TT	c.(6727-6729)GCA>TTA	p.A2243L	ASXL3_uc002kxq.2_Missense_Mutation_p.A1950L	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2243	PHD-type; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ACTTTGTGTAGCATGCCTGGTT	0.46													21	38					0	0	1	0	0
C18orf21	83608	broad.mit.edu	37	18	33558943	33558943	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:33558943T>C	uc002kzc.2	+	5	741	c.637T>C	c.(637-639)TCT>CCT	p.S213P	C18orf21_uc002kzd.2_Missense_Mutation_p.S125P	NM_031446	NP_113634	Q32NC0	CR021_HUMAN	chromosome 18 open reading frame 21	213											0						TTTCTTATCTTCTCTGAAGGG	0.313													18	23					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47369720	47369720	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:47369720G>A	uc002leb.2	-	34	4790	c.4502C>T	c.(4501-4503)CCC>CTC	p.P1501L	MYO5B_uc002ldz.2_Missense_Mutation_p.P71L|MYO5B_uc002lea.2_Missense_Mutation_p.P616L	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1501					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GATGTAGGCGGGGAGACAGGG	0.557													27	27					0	0	1	0	0
POLI	11201	broad.mit.edu	37	18	51820450	51820450	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:51820450T>C	uc002lfj.3	+	10	1904	c.1836T>C	c.(1834-1836)TCT>TCC	p.S612S	POLI_uc010xds.1_Silent_p.S533S|POLI_uc002lfk.3_Silent_p.S509S|POLI_uc010dpg.2_Silent_p.S208S	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	612	Ser-rich.				DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		GCAGTAGTTCTTCTTACATGT	0.353								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					21	27					0	0	1	0	0
STARD6	147323	broad.mit.edu	37	18	51851242	51851242	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:51851242G>A	uc010xdt.1	-	6	483	c.483C>T	c.(481-483)AAC>AAT	p.N161N		NM_139171	NP_631910	P59095	STAR6_HUMAN	START domain containing protein 6	161	START.				lipid transport		lipid binding			ovary(1)	1				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		AATATGCTGGGTTTCTGTAAG	0.328													14	18					0	0	1	0	0
RAB27B	5874	broad.mit.edu	37	18	52556605	52556605	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:52556605G>A	uc002lfr.2	+	6	729	c.618G>A	c.(616-618)TTG>TTA	p.L206L		NM_004163	NP_004154	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	206					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity				0				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		CTGGAAACTTGGATGGGGAAA	0.393													11	20					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52586522	52586522	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:52586522G>A	uc002lfs.2	-	9	941	c.769C>T	c.(769-771)CTG>TTG	p.L257L	CCDC68_uc002lft.2_Silent_p.L257L	NM_001143829	NP_001137301	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	257	Potential.									skin(1)	1				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		ACACTGCGCAGGTTCTGATGT	0.473													46	73					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	52901899	52901899	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:52901899C>T	uc002lfz.2	-	16	1978	c.1366G>A	c.(1366-1368)GAA>AAA	p.E456K	TCF4_uc002lfw.3_Missense_Mutation_p.E296K|TCF4_uc010xdu.1_Missense_Mutation_p.E326K|TCF4_uc010xdv.1_Missense_Mutation_p.E326K|TCF4_uc002lfx.2_Missense_Mutation_p.E385K|TCF4_uc010xdw.1_Missense_Mutation_p.E326K|TCF4_uc002lfy.2_Missense_Mutation_p.E414K|TCF4_uc010xdx.1_Missense_Mutation_p.E432K|TCF4_uc010dph.1_Missense_Mutation_p.E456K|TCF4_uc010xdy.1_Missense_Mutation_p.E432K|TCF4_uc002lga.2_Missense_Mutation_p.E558K|TCF4_uc002lgb.1_Missense_Mutation_p.E296K|TCF4_uc010dpi.2_Missense_Mutation_p.E462K|TCF4_uc002lfv.2_Missense_Mutation_p.E239K	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	456					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		ACGCCATCTTCACGATGGGTC	0.592											OREG0024990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	44					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	52921820	52921820	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:52921820C>T	uc002lfz.2	-	15	1870	c.1258G>A	c.(1258-1260)GGA>AGA	p.G420R	TCF4_uc002lfw.3_Missense_Mutation_p.G260R|TCF4_uc010xdu.1_Missense_Mutation_p.G290R|TCF4_uc010xdv.1_Missense_Mutation_p.G290R|TCF4_uc002lfx.2_Missense_Mutation_p.G349R|TCF4_uc010xdw.1_Missense_Mutation_p.G290R|TCF4_uc002lfy.2_Missense_Mutation_p.G378R|TCF4_uc010xdx.1_Missense_Mutation_p.G396R|TCF4_uc010dph.1_Missense_Mutation_p.G420R|TCF4_uc010xdy.1_Missense_Mutation_p.G396R|TCF4_uc002lga.2_Missense_Mutation_p.G522R|TCF4_uc002lgb.1_Missense_Mutation_p.G260R|TCF4_uc010dpi.2_Missense_Mutation_p.G426R|TCF4_uc002lfv.2_Missense_Mutation_p.G203R	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	420					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		CCAATGATTCCATGCATGTCC	0.502													13	19					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55020174	55020174	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:55020174C>T	uc002lgn.2	+	1	454	c.97C>T	c.(97-99)CTG>TTG	p.L33L		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	33	Helical; Signal-anchor for type II membrane protein; (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CTACGTGTCCCTGAAAAAGGA	0.597													32	26					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024487	55024487	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:55024487G>A	uc002lgn.2	+	3	1003	c.646G>A	c.(646-648)GAA>AAA	p.E216K		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	216	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CAGCATCCTGGAAAAATATTA	0.408													18	33					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202905	56202905	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:56202905G>A	uc002lhj.3	-	5	4728	c.4514C>T	c.(4513-4515)CCA>CTA	p.P1505L	ALPK2_uc002lhk.1_Missense_Mutation_p.P836L	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1505							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						ACATCCACTTGGAATTCTTTC	0.483													17	39					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56204774	56204774	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:56204774C>T	uc002lhj.3	-	5	2859	c.2645G>A	c.(2644-2646)GGC>GAC	p.G882D	ALPK2_uc002lhk.1_Missense_Mutation_p.G213D	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	882							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GACTGAGTTGCCGTCCTTGCT	0.438													17	26					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56246930	56246930	+	Missense_Mutation	SNP	C	T	T	rs140973320	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:56246930C>T	uc002lhj.3	-	4	1292	c.1078G>A	c.(1078-1080)GAT>AAT	p.D360N		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	360							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TCTTCGTCATCGCTTTCTAAT	0.502											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	27					0	0	1	0	0
KDSR	2531	broad.mit.edu	37	18	61018276	61018276	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:61018276G>A	uc010dpw.2	-	6	609	c.454C>T	c.(454-456)CCC>TCC	p.P152S	KDSR_uc010xem.1_Intron	NM_002035	NP_002026	Q06136	KDSR_HUMAN	3-ketodihydrosphingosine reductase precursor	152	Cytoplasmic (Potential).				3-keto-sphinganine metabolic process	endoplasmic reticulum membrane|extracellular space|integral to membrane	3-dehydrosphinganine reductase activity|binding			skin(1)	1						GCCCGGCTGGGGTACACGCTG	0.552													33	50					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61260157	61260157	+	Missense_Mutation	SNP	G	A	A	rs138290904		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:61260157G>A	uc002ljc.2	+	5	592	c.424G>A	c.(424-426)GAT>AAT	p.D142N	SERPINB13_uc002ljd.2_5'UTR|SERPINB13_uc010xep.1_Missense_Mutation_p.D151N|SERPINB13_uc010xeq.1_Intron|SERPINB13_uc010xer.1_Intron	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	142					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1						AAATGCAGCCGATGAAAGTCG	0.323													21	34					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61305175	61305175	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:61305175C>T	uc002ljf.2	-	8	1037	c.951G>A	c.(949-951)ATG>ATA	p.M317I	SERPINB4_uc002lje.2_Missense_Mutation_p.M296I|SERPINB4_uc002ljg.2_Missense_Mutation_p.M317I	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	317					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						GGCTCCAGGTCATGCCTGAGA	0.517													32	48					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65180610	65180610	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:65180610G>A	uc002lke.1	-	2	2490	c.1266C>T	c.(1264-1266)TTC>TTT	p.F422F		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	412						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				CCCAGTTAGGGAATGTGTGTA	0.493													14	30					0	0	1	0	0
CNDP2	55748	broad.mit.edu	37	18	72186193	72186193	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:72186193T>C	uc002llm.1	+	11	1382	c.1220T>C	c.(1219-1221)GTT>GCT	p.V407A	CNDP2_uc002lln.1_Missense_Mutation_p.V323A|CNDP2_uc010dqs.2_Intron	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	407						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		GTTTTTGGTGTTGAGCCAGAC	0.547													30	46					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74091512	74091512	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr18:74091512G>A	uc010dqx.1	-	3	2793	c.2558C>T	c.(2557-2559)CCC>CTC	p.P853L	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	853					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CACTCCCAGGGGAGAAGAGCC	0.627													60	66					0	0	1	0	0
RPS15	6209	broad.mit.edu	37	19	1440453	1440453	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:1440453C>T	uc002lsp.1	+	4	492	c.430C>T	c.(430-432)CTC>TTC	p.L144F	RPS15_uc002lsq.1_Missense_Mutation_p.L151F	NM_001018	NP_001009	P62841	RS15_HUMAN	ribosomal protein S15	144					endocrine pancreas development|ribosomal small subunit export from nucleus|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleoplasm	DNA binding|protein binding|RNA binding				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCATCCCTCTCAAGTAATG	0.612													48	6					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1785534	1785534	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:1785534G>A	uc002ltw.2	-	26	3561	c.3327C>T	c.(3325-3327)AGC>AGT	p.S1109S	ATP8B3_uc002ltv.2_Silent_p.S1072S|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1109	Extracellular (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCGCTGAAGCTGGCGGGTC	0.627													43	6					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2216581	2216581	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:2216581C>A	uc002lvb.3	+	20	2261	c.2225C>A	c.(2224-2226)CCC>CAC	p.P742H	DOT1L_uc002lvc.1_Missense_Mutation_p.P36H|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_Missense_Mutation_p.P36H	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	742						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGCCTCACCCCTGGACCAG	0.672													29	66					4.87955e-14	4.93442e-14	1	1	0
ATCAY	85300	broad.mit.edu	37	19	3905638	3905638	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:3905638G>A	uc002lyy.3	+	4	773	c.343G>A	c.(343-345)GAA>AAA	p.E115K	ATCAY_uc010xhz.1_Missense_Mutation_p.E121K	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	115					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		GAATGGCAACGAACTGGAGTG	0.577													34	83					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3910877	3910877	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:3910877C>T	uc002lyy.3	+	8	1286	c.856C>T	c.(856-858)CCT>TCT	p.P286S	ATCAY_uc010xhz.1_Missense_Mutation_p.P292S|ATCAY_uc010dts.2_Missense_Mutation_p.P43S	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	286	CRAL-TRIO.				transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		CATCTCTCGCCCTTTCATCAG	0.433													18	54					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5082414	5082414	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:5082414C>T	uc002mbq.3	+	9	1043	c.817C>T	c.(817-819)CCC>TCC	p.P273S	KDM4B_uc010xil.1_Missense_Mutation_p.P273S|KDM4B_uc010xim.1_Missense_Mutation_p.P273S|KDM4B_uc002mbr.3_Missense_Mutation_p.P31S	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	273	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						GATCACATTTCCCTACGGCTA	0.597													25	5					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065405	9065405	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:9065405G>A	uc002mkp.2	-	3	22245	c.22041C>T	c.(22039-22041)ACC>ACT	p.T7347T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7349	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGAGGGAGTGGTTGATGTGT	0.488													59	9					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9066554	9066554	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:9066554A>T	uc002mkp.2	-	3	21096	c.20892T>A	c.(20890-20892)TTT>TTA	p.F6964L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6966	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTCAGTGGAAAAGCTGGCAT	0.458													160	11					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074082	9074082	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:9074082G>A	uc002mkp.2	-	3	13568	c.13364C>T	c.(13363-13365)TCC>TTC	p.S4455F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4457	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTGTCAGGGAAGAGGGATA	0.493													73	10					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204125	9204125	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:9204125G>A	uc010xkj.1	+	1	205	c.205G>A	c.(205-207)GTT>ATT	p.V69I		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						CCTGTCCCTGGTTGATTTCTG	0.557													4	61					0	0	1	0	0
ZNF699	374879	broad.mit.edu	37	19	9406189	9406189	+	Nonsense_Mutation	SNP	G	A	A	rs145027997	by1000genomes	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:9406189G>A	uc002mlc.1	-	5	1891	c.1891C>T	c.(1891-1893)CGA>TGA	p.R631*		NM_198535	NP_940937	Q32M78	ZN699_HUMAN	zinc finger protein 699	631	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACATGCCTTCGAAAGTAGGCA	0.423													30	53					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15284925	15284925	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:15284925C>A	uc002nan.2	-	25	4766	c.4690G>T	c.(4690-4692)GGC>TGC	p.G1564C		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1564	Extracellular (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GGTTCGGAGCCAGGACTAGGC	0.687													4	39					0.000602214	0.000603473	1	1	0
OR10H2	26538	broad.mit.edu	37	19	15838913	15838913	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:15838913C>T	uc002nbm.2	+	1	80	c.60C>T	c.(58-60)TTC>TTT	p.F20F		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					TCTCTGCCTTCCCCCACCTCC	0.577													179	24					0	0	1	0	0
CALR3	125972	broad.mit.edu	37	19	16590074	16590074	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:16590074C>T	uc002ned.2	-	9	1086	c.1023G>A	c.(1021-1023)AGG>AGA	p.R341R	MED26_uc002nee.2_RNA	NM_145046	NP_659483	Q96L12	CALR3_HUMAN	calreticulin 3 precursor	341	Glu/Lys-rich.|C-domain.				protein folding	endoplasmic reticulum lumen	calcium ion binding|sugar binding|unfolded protein binding				0						CATCCATCTCCCTTTCTGGAC	0.348													30	83					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17735637	17735637	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:17735637C>T	uc002nhd.2	-	35	4462	c.4462G>A	c.(4462-4464)GTG>ATG	p.V1488M		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1400	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GCAGGTCTCACCGTCTGGTCA	0.582													39	5					0	0	1	0	0
MAP1S	55201	broad.mit.edu	37	19	17837396	17837396	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:17837396C>T	uc002nhe.1	+	5	1212	c.1203C>T	c.(1201-1203)CCC>CCT	p.P401P	MAP1S_uc010eaz.1_RNA|MAP1S_uc010eba.1_Silent_p.P401P|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Silent_p.P375P	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	401	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						TGCACCCGCCCTCCGCCGGCG	0.726													3	10					0	0	1	0	0
MAST3	23031	broad.mit.edu	37	19	18255881	18255881	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:18255881C>T	uc002nhz.3	+	23	2794	c.2794C>T	c.(2794-2796)CGT>TGT	p.R932C		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	932	Ser-rich.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						CCCGTCGTCCCGTGACTCTTC	0.672													20	72					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20215083	20215083	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:20215083C>T	uc002nor.2	+	2	178	c.39C>T	c.(37-39)TTC>TTT	p.F13F	ZNF90_uc002nos.1_RNA|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	13	KRAB.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CCATAGAATTCTCTCTGGAGG	0.423													55	10					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271909	22271909	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:22271909C>T	uc010ecx.2	+	4	1526	c.1357C>T	c.(1357-1359)CAT>TAT	p.H453Y	ZNF257_uc010ecy.2_Missense_Mutation_p.H421Y	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	453	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAAGATAATTCATACTGGAGA	0.393													27	5					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22364321	22364321	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:22364321C>T	uc002nqs.1	-	3	516	c.198G>A	c.(196-198)ATG>ATA	p.M66I		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	66					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TTCTCAATATCATTTTTTGGA	0.303													45	5					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22939406	22939406	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:22939406C>T	uc010xrh.1	-	7	2765	c.2765G>A	c.(2764-2766)GGC>GAC	p.G922D		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAAAGCTTTGCCACATTCTTC	0.363													33	4					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31770312	31770312	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:31770312G>A	uc002nsy.3	-	2	452	c.387C>T	c.(385-387)TCC>TCT	p.S129S		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	129					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TGGACCAGTAGGAGTTGGAGA	0.423													14	57					0	0	1	0	0
KIAA0355	9710	broad.mit.edu	37	19	34833066	34833066	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:34833066C>T	uc002nvd.3	+	10	3086	c.2227C>T	c.(2227-2229)CCG>TCG	p.P743S		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	743										ovary(1)	1	Esophageal squamous(110;0.162)					GCCCATTGGACCGCAGCAGCC	0.622													53	168					0	0	1	0	0
ZNF599	148103	broad.mit.edu	37	19	35258237	35258237	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:35258237G>A	uc010edn.1	-	3	613	c.225C>T	c.(223-225)TCC>TCT	p.S75S	ZNF599_uc010edm.1_Silent_p.S38S|ZNF599_uc010xsd.1_RNA|ZNF599_uc010edo.1_RNA	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	75	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			AGGTGCTTTGGGAGAGGCCTC	0.552													38	5					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35449231	35449231	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:35449231C>T	uc002nxh.1	-	4	1915	c.1528G>A	c.(1528-1530)GAA>AAA	p.E510K		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	510	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TTCCCACATTCACTGCACTGG	0.498													39	4					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39025973	39025973	+	Silent	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:39025973T>A	uc002oit.2	+	81	11587	c.11457T>A	c.(11455-11457)CTT>CTA	p.L3819L	RYR1_uc002oiu.2_Silent_p.L3814L|RYR1_uc002oiv.1_Silent_p.L734L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3819					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGGATTATCTTAAGGACAAGA	0.498													24	81					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40433602	40433602	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:40433602G>A	uc002omp.3	-	2	675	c.667C>T	c.(667-669)CTC>TTC	p.L223F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	223	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGGCCAGAGAGGACAGCCACG	0.572													65	12					0	0	1	0	0
CNTD2	79935	broad.mit.edu	37	19	40732323	40732323	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:40732323C>T	uc010xvi.1	-	1	275	c.226G>A	c.(226-228)GGA>AGA	p.G76R	CNTD2_uc002ond.2_RNA	NM_024877	NP_079153	Q9H8S5	CNTD2_HUMAN	cyclin N-terminal domain containing 2 isoform 2	76					regulation of cyclin-dependent protein kinase activity		protein kinase binding				0						TCGCGTTCTCCCTGCAGCCCC	0.751													7	30					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41599627	41599627	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:41599627C>T	uc002opt.2	+	6	933	c.924C>T	c.(922-924)ACC>ACT	p.T308T		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	308					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	CCGTGAGCACCACCCTGCGCT	0.567													83	10					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42848976	42848976	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:42848976G>A	uc002otl.3	+	12	2723	c.2088G>A	c.(2086-2088)CAG>CAA	p.Q696Q	MEGF8_uc002otm.3_Silent_p.Q237Q	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				ATACCTCCCAGCCTGACAAGG	0.562													112	14					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699348	43699348	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:43699348C>T	uc002ovy.2	-	4	889	c.787G>A	c.(787-789)GAA>AAA	p.E263K	PSG6_uc010xwk.1_Intron|PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.E170K|PSG4_uc002ovz.2_Intron	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	263	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				CTCTTAGGTTCACAGGTGAAG	0.453													108	227					0	0	1	0	0
Unknown	0	broad.mit.edu	37	19	44503323	44503324	+	RNA	DNP	TT	CA	CA			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:44503323_44503324TT>CA	uc010ejc.1	-	2		c.628_629AA>TG			uc002oya.1_RNA					Homo sapiens cDNA FLJ33234 fis, clone ASTRO2002064.																		AAGCAGTTCCTTTTGAGTTTGT	0.351													10	24					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44604989	44604989	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:44604989C>T	uc002oyh.1	+	4	353	c.51C>T	c.(49-51)TTC>TTT	p.F17F		NM_013398	NP_037530	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	17	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				CTGTGGTCTTCACTGAGGAAG	0.522													44	126					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45322740	45322740	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:45322740C>T	uc002ozu.2	+	12	1655	c.1611C>T	c.(1609-1611)TTC>TTT	p.F537F	BCAM_uc002ozt.1_Silent_p.F537F	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	537	Extracellular (Potential).|Ig-like C2-type 3.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				TCTTCCACTTCGGCACCGGTG	0.642													355	47					0	0	1	0	0
APOC1	341	broad.mit.edu	37	19	45419533	45419533	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:45419533C>T	uc002pac.1	+	4	397	c.145C>T	c.(145-147)CGG>TGG	p.R49W	APOC1_uc002pad.1_Missense_Mutation_p.R49W|APOC1_uc002pae.1_Missense_Mutation_p.R49W|APOC1_uc002paf.1_RNA	NM_001645	NP_001636	P02654	APOC1_HUMAN	apolipoprotein C-I precursor	49					cholesterol efflux|chylomicron remnant clearance|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol transport|negative regulation of fatty acid biosynthetic process|negative regulation of lipoprotein lipase activity|negative regulation of phosphatidylcholine catabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of very-low-density lipoprotein particle clearance|phospholipid efflux|positive regulation of cholesterol esterification|very-low-density lipoprotein particle assembly|very-low-density lipoprotein particle clearance	chylomicron|endoplasmic reticulum|high-density lipoprotein particle|very-low-density lipoprotein particle	fatty acid binding|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipase inhibitor activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)		GGACAAGGCTCGGGAACTCAT	0.577													218	33					0	0	1	0	0
CLPTM1	1209	broad.mit.edu	37	19	45489794	45489794	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:45489794C>T	uc002pai.2	+	7	769	c.754C>T	c.(754-756)CCG>TCG	p.P252S	CLPTM1_uc010ejv.1_Missense_Mutation_p.P150S|CLPTM1_uc010xxf.1_Missense_Mutation_p.P150S|CLPTM1_uc010xxg.1_Missense_Mutation_p.P238S	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	252	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		CGACCACACGCCGTGGGTGAA	0.622													470	73					0	0	1	0	0
DMPK	1760	broad.mit.edu	37	19	46275981	46275981	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:46275981A>T	uc002pdd.1	-	9	1836	c.1292T>A	c.(1291-1293)ATG>AAG	p.M431K	DMPK_uc010xxs.1_Missense_Mutation_p.M332K|DMPK_uc002pde.1_Missense_Mutation_p.M426K|DMPK_uc002pdf.1_Missense_Mutation_p.M421K|DMPK_uc002pdg.1_Missense_Mutation_p.M416K|DMPK_uc002pdh.1_Missense_Mutation_p.M416K|DMPK_uc002pdi.1_Missense_Mutation_p.M447K|DMPK_uc010xxt.1_Missense_Mutation_p.M416K	NM_001081563	NP_001075032	Q09013	DMPK_HUMAN	myotonic dystrophy protein kinase isoform 1	431					regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)	3		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		CTCCAGTTCCATGGGTGTGGG	0.617													21	41					0	0	1	0	0
DMPK	1760	broad.mit.edu	37	19	46280657	46280657	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:46280657G>A	uc002pdd.1	-	7	1648	c.1104C>T	c.(1102-1104)TTC>TTT	p.F368F	DMPK_uc010xxs.1_Silent_p.F269F|DMPK_uc002pde.1_Silent_p.F368F|DMPK_uc002pdf.1_Silent_p.F358F|DMPK_uc002pdg.1_Silent_p.F358F|DMPK_uc002pdh.1_Silent_p.F358F|DMPK_uc002pdi.1_Silent_p.F384F|DMPK_uc010xxt.1_Silent_p.F358F	NM_001081563	NP_001075032	Q09013	DMPK_HUMAN	myotonic dystrophy protein kinase isoform 1	368	AGC-kinase C-terminal.				regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)	3		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		TGGCACCTTCGAAATCCGGTG	0.647													63	7					0	0	1	0	0
NOVA2	4858	broad.mit.edu	37	19	46443358	46443358	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:46443358A>G	uc002pdv.2	-	4	1290	c.1242T>C	c.(1240-1242)CCT>CCC	p.P414P		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	414	KH 3.					nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		CCAGGTTCTCAGGCACCGCAA	0.512													4	124					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46825094	46825094	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:46825094G>A	uc002peh.2	+	10	1235	c.1206G>A	c.(1204-1206)CTG>CTA	p.L402L	HIF3A_uc002peg.3_Silent_p.L402L|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Silent_p.L346L|HIF3A_uc002pej.1_Silent_p.L333L|HIF3A_uc002pek.2_Silent_p.L346L|HIF3A_uc010xxy.1_Silent_p.L333L|HIF3A_uc002pel.2_Silent_p.L400L|HIF3A_uc010xxz.1_Silent_p.L351L	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		AGGCTGCCCTGGCCGCTGACC	0.692													69	4					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49132047	49132047	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:49132047C>T	uc002pjr.2	+	7	1348	c.982C>T	c.(982-984)CGC>TGC	p.R328C	SPHK2_uc010xzt.1_Missense_Mutation_p.R269C|SPHK2_uc002pjs.2_Missense_Mutation_p.R328C|SPHK2_uc002pjt.2_Missense_Mutation_p.R122C|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Missense_Mutation_p.R292C|SPHK2_uc002pjw.2_Missense_Mutation_p.R390C	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	328					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CTCGGGCTCCCGCTGTTTCTC	0.647													133	13					0	0	1	0	0
BAX	581	broad.mit.edu	37	19	49464068	49464068	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:49464068C>T	uc002plk.2	+	5	440	c.371C>T	c.(370-372)GCC>GTC	p.A124V	BAX_uc002plf.1_Missense_Mutation_p.A124V|BAX_uc002plg.1_Missense_Mutation_p.A87V|BAX_uc002plh.1_Missense_Mutation_p.A46V|BAX_uc010xzx.1_RNA|BAX_uc002plj.2_Missense_Mutation_p.A124V|BAX_uc002pll.2_Missense_Mutation_p.A75V|BAX_uc002plm.2_Missense_Mutation_p.A46V	NM_138761	NP_620116	Q07812	BAX_HUMAN	BCL2-associated X protein isoform alpha	124					activation of caspase activity by cytochrome c|activation of pro-apoptotic gene products|B cell apoptosis|cleavage of lamin|DNA fragmentation involved in apoptotic nuclear change|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|induction of retinal programmed cell death|mitochondrial fragmentation involved in apoptosis|mitochondrial fusion|negative regulation of protein binding|negative regulation of survival gene product expression|nuclear fragmentation involved in apoptotic nuclear change|positive regulation of neuron apoptosis|protein homooligomerization|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria|release of matrix enzymes from mitochondria|response to toxin|transformed cell apoptosis	cytosol|endoplasmic reticulum membrane|mitochondrial outer membrane|mitochondrial permeability transition pore complex|nucleus	BH3 domain binding|channel activity|lipid binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000159)|all cancers(93;0.00047)|GBM - Glioblastoma multiforme(486;0.018)|Epithelial(262;0.0279)		TCCCCACAGGCCCTGTGCACC	0.587													68	9					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50209290	50209290	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:50209290G>A	uc002ppj.2	+	10	1294	c.1089G>A	c.(1087-1089)CAG>CAA	p.Q363Q	CPT1C_uc002ppl.3_Silent_p.Q329Q|CPT1C_uc002ppi.2_Silent_p.Q280Q|CPT1C_uc002ppk.2_Silent_p.Q352Q|CPT1C_uc010eng.2_Silent_p.Q363Q|CPT1C_uc010enh.2_Silent_p.Q363Q|CPT1C_uc010ybc.1_Silent_p.Q234Q|CPT1C_uc010eni.1_Silent_p.Q20Q	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	363	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		AGCAGTTTCAGAGAATCCTGG	0.637													57	6					0	0	1	0	0
PNKP	11284	broad.mit.edu	37	19	50370408	50370408	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:50370408T>C	uc002pqh.2	-	1	106	c.54A>G	c.(52-54)GGA>GGG	p.G18G	PNKP_uc002pqg.2_5'Flank|PNKP_uc002pqi.2_5'UTR|PNKP_uc002pqj.2_Silent_p.G18G|PNKP_uc010enm.2_Silent_p.G18G|PNKP_uc002pqk.2_Silent_p.G18G	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	18				G -> E (in Ref. 1; AAD51135).	DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		TGGGGGGCGCTCCCCCAGGGG	0.711								Other_BER_factors					7	32					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51645698	51645699	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:51645698_51645699GG>AA	uc002pvv.1	+	1	141_142	c.72_73GG>AA	c.(70-75)AAGGAT>AAAAAT	p.D25N	SIGLEC7_uc002pvw.1_Missense_Mutation_p.D25N|SIGLEC7_uc010eoq.1_RNA|SIGLEC7_uc010eor.1_Missense_Mutation_p.D25N	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	25	Extracellular (Potential).				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		GTAACCGGAAGGATTACTCGCT	0.515													5	40					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249272	52249272	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:52249272C>T	uc002pxq.2	-	2	1071	c.976G>A	c.(976-978)GAG>AAG	p.E326K		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	326	Cytoplasmic (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GTTGAGTCCTCGGTCAGGGCC	0.572													127	15					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53669202	53669202	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:53669202C>T	uc010eqm.1	-	4	641	c.541G>A	c.(541-543)GAT>AAT	p.D181N		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	116	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		CCACATTCATCACATTTATAA	0.378													46	117					0	0	1	0	0
MIR517C	574492	broad.mit.edu	37	19	54244631	54244631	+	RNA	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:54244631T>A	hsa-mir-517c|MI0003174	+			c.65T>A			MIR520H_hsa-mir-520h|MI0003175_5'Flank|uc010yeb.1_5'Flank																	0						AGATCGTGCATCCTTTTAGAG	0.403													14	34					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54392969	54392969	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:54392969C>T	uc002qcq.1	+	4	645	c.363C>T	c.(361-363)CTC>CTT	p.L121L	PRKCG_uc010eqz.1_Silent_p.L121L|PRKCG_uc010yef.1_Silent_p.L121L|PRKCG_uc010yeg.1_Silent_p.L121L|PRKCG_uc010yeh.1_Intron	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	121	Phorbol-ester/DAG-type 2.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		GCTCCCTCCTCTACGGGCTTG	0.627													22	2					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54849322	54849322	+	Silent	SNP	G	A	A	rs146578434		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:54849322G>A	uc002qfj.2	-	4	597	c.540C>T	c.(538-540)TTC>TTT	p.F180F	LILRA4_uc002qfi.2_Silent_p.F114F	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	180	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GGCCCATGGGGAACAGGGCCT	0.567													30	44					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55144654	55144654	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:55144654C>T	uc002qgj.2	+	8	1486	c.1146C>T	c.(1144-1146)TTC>TTT	p.F382F	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Silent_p.F382F|LILRB1_uc002qgk.2_Silent_p.F382F|LILRB1_uc002qgm.2_Silent_p.F382F|LILRB1_uc010erq.2_Silent_p.F382F|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	382	Ig-like C2-type 4.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		AGGCTGAATTCCCCATGGGTC	0.562										HNSCC(37;0.09)			44	120					0	0	1	0	0
KIR3DP1	768329	broad.mit.edu	37	19	55297959	55297959	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:55297959G>A	uc010yfi.1	+	3	116	c.115G>A	c.(115-117)GTG>ATG	p.V39M	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_Intron	NM_001015070	NP_001015070			killer-cell Ig-like receptor												0				GBM - Glioblastoma multiforme(193;0.0192)		CAGCCCTGTGGTGTCTGAAGG	0.572													47	2					0	0	1	0	0
KIR2DS4	3809	broad.mit.edu	37	19	55349152	55349152	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:55349152G>A	uc002qhm.1	+	3	238	c.192G>A	c.(190-192)GGG>GGA	p.G64G	KIR2DS4_uc010yfj.1_Silent_p.G57G|KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Silent_p.G64G|KIR2DS4_uc002qhn.1_Silent_p.G11G	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	64	Extracellular (Potential).|Ig-like C2-type 1.					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		ACAGAGAGGGGAAGTTTAACA	0.512													224	23					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56473545	56473545	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:56473545T>G	uc002qmh.2	+	4	2226	c.2155T>G	c.(2155-2157)TTT>GTT	p.F719V	NLRP8_uc010etg.2_Missense_Mutation_p.F719V	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	719						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GGGGCCTCCTTTTTTGAAGGC	0.488													42	66					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640197	57640197	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:57640197C>T	uc002qny.2	+	4	510	c.154C>T	c.(154-156)CAG>TAG	p.Q52*		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	52					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAGAATTTTTCAGCTGAGCAA	0.338													30	3					0	0	1	0	0
ZNF749	388567	broad.mit.edu	37	19	57955885	57955885	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:57955885C>G	uc002qoq.2	+	3	1623	c.1369C>G	c.(1369-1371)CAG>GAG	p.Q457E	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	457	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		AGTTCAGCACCAGAAAATCCA	0.423													3	87					0	0	1	0	0
ZNF606	80095	broad.mit.edu	37	19	58490579	58490579	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:58490579C>T	uc002qqw.2	-	7	2087	c.1469G>A	c.(1468-1470)GGG>GAG	p.G490E	ZNF606_uc010yhp.1_Missense_Mutation_p.G400E	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	490	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		GAAAGATTTCCCACACTCATT	0.368													8	28					0	0	1	0	0
ZNF606	80095	broad.mit.edu	37	19	58491146	58491146	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:58491146A>G	uc002qqw.2	-	7	1520	c.902T>C	c.(901-903)ATA>ACA	p.I301T	ZNF606_uc010yhp.1_Missense_Mutation_p.I211T	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	301	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		AAAATGTATTATATGATTGAA	0.313													74	5					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565085	58565085	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:58565085G>A	uc002qrc.1	+	6	1140	c.893G>A	c.(892-894)GGG>GAG	p.G298E		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	298	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCCGACTGTGGGATGGTCTTC	0.632													67	7					0	0	1	0	0
MZF1	7593	broad.mit.edu	37	19	59080695	59080695	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:59080695C>A	uc002qto.2	-	5	1282	c.721G>T	c.(721-723)GAG>TAG	p.E241*	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Nonsense_Mutation_p.E241*|MZF1_uc010euu.1_Nonsense_Mutation_p.E282*	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	241					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		CTGGGGTGCTCCCTCCATGAG	0.607													18	36					3.32936e-07	3.34797e-07	1	1	0
PXDN	7837	broad.mit.edu	37	2	1647274	1647275	+	Missense_Mutation	DNP	AT	CC	CC			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:1647274_1647275AT>CC	uc002qxa.2	-	19	3881_3882	c.3817_3818AT>GG	c.(3817-3819)ATC>GGC	p.I1273G		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1273					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GTCGCATAGGATCCTGGCCAGC	0.604													3	29					0	0	1	0	0
MYCN	4613	broad.mit.edu	37	2	16085827	16085827	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:16085827C>T	uc002rci.2	+	3	1303	c.1003C>T	c.(1003-1005)CCC>TCC	p.P335S	MYCN_uc010yjr.1_Missense_Mutation_p.P327S	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	335					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CTATGCCGCCCCCTCTCCCTA	0.612			A		neuroblastoma								11	16					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16745268	16745268	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:16745268G>A	uc010exm.1	-	4	435	c.287C>T	c.(286-288)TCC>TTC	p.S96F	FAM49A_uc002rck.1_Missense_Mutation_p.S96F	NM_030797	NP_110424	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	96						intracellular					0	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			TAGTCTAATGGAAAACTCGTA	0.418													10	18					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25972870	25972870	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:25972870C>T	uc002rgs.2	-	11	1776	c.1555G>A	c.(1555-1557)GAA>AAA	p.E519K	ASXL2_uc002rgt.1_Missense_Mutation_p.E259K	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	519					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACTAAAGATTCTTGGCTTTCA	0.458													28	59					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26700092	26700092	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:26700092T>C	uc002rhk.2	-	21	2598	c.2471A>G	c.(2470-2472)AAG>AGG	p.K824R	OTOF_uc002rhh.2_Missense_Mutation_p.K77R|OTOF_uc002rhi.2_Missense_Mutation_p.K134R|OTOF_uc002rhj.2_Missense_Mutation_p.K77R	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	824	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCCTCAGCTTGTCCCGCAC	0.652													10	11					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26781399	26781399	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:26781399C>T	uc002rhk.2	-	1	168	c.41G>A	c.(40-42)CGG>CAG	p.R14Q		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	14	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCCCTGCCCCGCAGCTCCGA	0.652													20	41					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27455060	27455060	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:27455060C>T	uc002rji.2	+	17	2775	c.2613C>T	c.(2611-2613)TTC>TTT	p.F871F	CAD_uc010eyw.2_Silent_p.F808F	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	871	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GTCTTGGCTTCTCAGACAAAC	0.547													31	37					0	0	1	0	0
SRD5A2	6716	broad.mit.edu	37	2	31751289	31751290	+	Missense_Mutation	DNP	CT	TC	TC			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:31751289_31751290CT>TC	uc002rnw.1	-	6	812_813	c.741_742AG>GA	c.(739-744)AAAGCC>AAGACC	p.A248T		NM_000348	NP_000339	P31213	S5A2_HUMAN	3-oxo-5 alpha-steroid 4-dehydrogenase 2	248					androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity				0	Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	GGAATAAGGGCTTTCCGAGATT	0.391													5	4					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32733298	32733298	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:32733298C>T	uc010ezu.2	+	51	10086	c.9952C>T	c.(9952-9954)CCA>TCA	p.P3318S		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3318					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TCCATTCCTTCCATCTGAAGA	0.373													10	9					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33413645	33413645	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:33413645G>A	uc002ros.2	+	7	1428	c.1428G>A	c.(1426-1428)GTG>GTA	p.V476V	LTBP1_uc002rot.2_Silent_p.V150V|LTBP1_uc002rou.2_Silent_p.V150V|LTBP1_uc002rov.2_Silent_p.V150V|LTBP1_uc010ymz.1_Silent_p.V150V|LTBP1_uc010yna.1_Silent_p.V150V	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	476					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CTGTTGTAGTGAAATTTCCTC	0.368													25	32					0	0	1	0	0
KCNG3	170850	broad.mit.edu	37	2	42671467	42671467	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:42671467G>A	uc002rsn.2	-	2	1514	c.918C>T	c.(916-918)TTC>TTT	p.F306F	KCNG3_uc002rsm.2_Silent_p.F295F	NM_133329	NP_579875	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G,	306	Helical; Voltage-sensor; Name=Segment S4; (Potential).					endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)	1						GAAGACCAATGAAGTGACGGG	0.453													13	12					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48921420	48921420	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:48921420G>A	uc002rwu.3	-	10	960	c.890C>T	c.(889-891)TCT>TTT	p.S297F	GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_RNA	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	297	Extracellular (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AAAGTTTTCAGAAATGGAATG	0.353									Familial_Male-Limited_Precocious_Puberty				6	8					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688615	60688615	+	Silent	SNP	G	A	A	rs113369532		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:60688615G>A	uc002sae.1	-	4	1660	c.1432C>T	c.(1432-1434)CTG>TTG	p.L478L	BCL11A_uc002sab.2_Silent_p.L478L|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Silent_p.L147L|BCL11A_uc010ypj.1_Silent_p.L444L|BCL11A_uc002sad.1_Silent_p.L326L|BCL11A_uc002saf.1_Silent_p.L444L	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	478					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			tccGGGATCAGGTTGGGGTCG	0.428			T	IGH@	B-CLL								71	101					0	0	1	0	0
EHBP1	23301	broad.mit.edu	37	2	63086369	63086369	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:63086369C>T	uc002sby.2	+	9	1287	c.805C>T	c.(805-807)CCA>TCA	p.P269S	EHBP1_uc010fcp.2_Missense_Mutation_p.P234S|EHBP1_uc002sbx.2_Missense_Mutation_p.P234S|EHBP1_uc002sbz.2_Missense_Mutation_p.P234S|EHBP1_uc002scb.2_Missense_Mutation_p.P234S	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	269						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			GAATTCAAATCCATTTGATGA	0.353									Hereditary_Prostate_Cancer				25	29					0	0	1	0	0
GFPT1	2673	broad.mit.edu	37	2	69555565	69555565	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:69555565G>A	uc002sfh.2	-	17	1856	c.1677C>T	c.(1675-1677)ATC>ATT	p.I559I		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	577	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						TAATTTCTTTGATTTTCTAAT	0.353													13	19					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74274262	74274262	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:74274262G>A	uc002skb.3	+	1	813	c.813G>A	c.(811-813)TGG>TGA	p.W271*	TET3_uc010fez.1_Nonsense_Mutation_p.W271*	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	271							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CTCCCTCATGGCCTGTGGTTC	0.582													25	32					0	0	1	0	0
LRRTM4	80059	broad.mit.edu	37	2	76975895	76975895	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:76975895G>A	uc002snr.2	-	4	2114	c.1699C>T	c.(1699-1701)CGA>TGA	p.R567*	LRRTM4_uc002snq.2_Nonsense_Mutation_p.R567*	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	567	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CTGTGGTCTCGGCCCAGCTCC	0.602													50	53					0	0	1	0	0
TCF7L1	83439	broad.mit.edu	37	2	85531398	85531398	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:85531398C>T	uc002soy.2	+	7	856	c.782C>T	c.(781-783)TCC>TTC	p.S261F		NM_031283	NP_112573	Q9HCS4	TF7L1_HUMAN	HMG-box transcription factor TCF-3	261	Pro-rich.				chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)|central_nervous_system(1)	3						CCCATGTACTCCCTTCCTCCC	0.612													20	31					0	0	1	0	0
FABP1	2168	broad.mit.edu	37	2	88425733	88425733	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:88425733C>T	uc002sst.1	-	2	244	c.202G>A	c.(202-204)GAA>AAA	p.E68K	FABP1_uc002ssu.2_Missense_Mutation_p.E68K	NM_001443	NP_001434	P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	68					organ morphogenesis						0						AGCTCACATTCCTCCCCCACC	0.527													79	123					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88472834	88472834	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:88472834G>A	uc002ssz.3	+	2	318	c.165G>A	c.(163-165)GTG>GTA	p.V55V	THNSL2_uc002ssv.2_Intron|THNSL2_uc002ssw.3_Silent_p.V55V|THNSL2_uc002ssx.3_Silent_p.V23V|THNSL2_uc002sta.3_Intron|THNSL2_uc002ssy.3_Silent_p.V55V	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	55					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						CTGGCCTGGTGAAGGAGCTGT	0.557													30	26					0	0	1	0	0
Unknown	0	broad.mit.edu	37	2	89544419	89544419	+	RNA	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:89544419G>A	uc010ytr.1	-	14		c.1766C>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		AGGCGCCTTGGAGATTGGCCT	0.517													45	72					0	0	1	0	0
ANKRD20B	729171	broad.mit.edu	37	2	95513772	95513772	+	RNA	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:95513772G>A	uc010fhp.2	-	5		c.633C>T				NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0						TTTGTCAAATGATGAGAAATA	0.348													25	350					0	0	1	0	0
SEMA4C	54910	broad.mit.edu	37	2	97526994	97526994	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:97526994G>A	uc002sxh.3	-	15	2031	c.1871C>T	c.(1870-1872)GCC>GTC	p.A624V	SEMA4C_uc002sxf.3_Missense_Mutation_p.A124V|SEMA4C_uc002sxe.2_Missense_Mutation_p.A165V|SEMA4C_uc002sxg.3_Missense_Mutation_p.A677V	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	624	Extracellular (Potential).|Ig-like C2-type.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						GCAGTGGTAGGCCCCGGCATG	0.711													16	19					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98828474	98828474	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:98828474G>A	uc002syo.2	+	13	2083	c.1819G>A	c.(1819-1821)GAT>AAT	p.D607N	VWA3B_uc010yvh.1_Missense_Mutation_p.D457N|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Missense_Mutation_p.D126N|VWA3B_uc002sym.2_Missense_Mutation_p.D607N|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.D264N|VWA3B_uc002syp.1_5'UTR|VWA3B_uc002syq.1_5'UTR|VWA3B_uc002syr.1_5'UTR	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	607	VWFA.									ovary(3)|large_intestine(2)|skin(1)	6						CCTTCTGACCGATGGGAGACC	0.483													23	33					0	0	1	0	0
LONRF2	164832	broad.mit.edu	37	2	100903441	100903441	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:100903441C>T	uc002tal.3	-	11	2645	c.2005G>A	c.(2005-2007)GAT>AAT	p.D669N	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	669	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						TTCATGCGATCCTGGAGAGAC	0.468													20	23					0	0	1	0	0
NMS	129521	broad.mit.edu	37	2	101099714	101099714	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:101099714G>A	uc002tan.1	+	10	457	c.450G>A	c.(448-450)CAG>CAA	p.Q150Q		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	150					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						CTTTTTTTAGGATTCAGTGGT	0.338													9	12					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101564795	101564795	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:101564795C>T	uc002tap.1	+	6	748	c.462C>T	c.(460-462)TCC>TCT	p.S154S	NPAS2_uc010yvt.1_Silent_p.S219S	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	154					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						TGACGGATTCCCCCTCCCCAG	0.338													10	30					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103142761	103142761	+	Missense_Mutation	SNP	A	C	C	rs115217520	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:103142761A>C	uc002tbz.3	+	11	2451	c.1994A>C	c.(1993-1995)AAT>ACT	p.N665T		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	665	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CCCTACGGGAATCCTCAGTCT	0.453													39	41					0	0	1	0	0
TMEM182	130827	broad.mit.edu	37	2	103431349	103431349	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:103431349C>T	uc010fjb.2	+	5	799	c.612C>T	c.(610-612)GCC>GCT	p.A204A	TMEM182_uc002tcc.3_Silent_p.A161A|TMEM182_uc002tcd.3_Silent_p.A108A|TMEM182_uc010ywe.1_RNA	NM_144632	NP_653233	Q6ZP80	TM182_HUMAN	transmembrane protein 182 precursor	204	Helical; (Potential).					integral to membrane					0						TTTTCCTGGCCCCAGCTGGGA	0.433													17	24					0	0	1	0	0
UXS1	80146	broad.mit.edu	37	2	106761704	106761704	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:106761704G>A	uc002tdm.2	-	6	497	c.399C>T	c.(397-399)ATC>ATT	p.I133I	UXS1_uc002tdn.2_Silent_p.I138I|UXS1_uc002tdo.2_Silent_p.I76I|UXS1_uc010ywh.1_Intron	NM_025076	NP_079352	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	133	NAD.|Lumenal (Potential).				cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2						TCTCATGTCCGATCCAGTGCT	0.517													9	30					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107040656	107040656	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:107040656T>A	uc010ywi.1	-	20	3824	c.3767A>T	c.(3766-3768)GAA>GTA	p.E1256V		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1256					intracellular transport		binding			ovary(1)	1						CAAAGCATCTTCCCTTAAATC	0.443													92	139					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108487691	108487691	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:108487691G>A	uc010ywk.1	+	20	3313	c.3231G>A	c.(3229-3231)TGG>TGA	p.W1077*	RGPD4_uc002tdu.2_Nonsense_Mutation_p.W264*|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1077	RanBD1 1.				intracellular transport		binding			skin(2)	2						TAAGGCAGTGGAAAGAAAGGG	0.393													133	177					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108487700	108487700	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:108487700G>A	uc010ywk.1	+	20	3322	c.3240G>A	c.(3238-3240)AGG>AGA	p.R1080R	RGPD4_uc002tdu.2_Silent_p.R267R|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1080	RanBD1 1.				intracellular transport		binding			skin(2)	2						GGAAAGAAAGGGGCTTGGGGA	0.388													127	190					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112786132	112786132	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:112786132C>T	uc002thk.1	+	19	2813	c.2691C>T	c.(2689-2691)ATC>ATT	p.I897I	MERTK_uc002thl.1_Silent_p.I721I	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	897	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						ACTTGAACATCGACCCTGACT	0.542													48	74					0	0	1	0	0
STEAP3	55240	broad.mit.edu	37	2	120003117	120003118	+	Missense_Mutation	DNP	GG	CA	CA			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:120003117_120003118GG>CA	uc002tlp.2	+	3	202_203	c.45_46GG>CA	c.(43-48)GTGGAC>GTCAAC	p.D16N	STEAP3_uc002tlq.2_Missense_Mutation_p.D26N|STEAP3_uc002tlr.2_Missense_Mutation_p.D16N|STEAP3_uc010fle.2_Missense_Mutation_p.D16N	NM_018234	NP_060704	Q658P3	STEA3_HUMAN	dudulin 2 isoform b	16	Cytoplasmic (Potential).				apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			central_nervous_system(2)|skin(1)	3						TCCACCTGGTGGACAGCGATAG	0.619													16	30					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128389895	128389895	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:128389895C>T	uc002top.2	+	38	5299	c.5246C>T	c.(5245-5247)CCC>CTC	p.P1749L	MYO7B_uc002tos.1_5'Flank|MYO7B_uc002tot.2_5'Flank	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1749	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GGGCTGCTGCCCCATGCCCAG	0.662													32	30					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133721423	133721423	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:133721423T>G	uc002ttp.2	-	8	823	c.449A>C	c.(448-450)GAG>GCG	p.E150A	NCKAP5_uc002ttq.2_Missense_Mutation_p.E150A|NCKAP5_uc002tts.1_Missense_Mutation_p.E125A	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	150	Potential.						protein binding				0						ATGTTTTCTCTCTTCCTCTGA	0.403													44	85					0	0	1	0	0
ACMSD	130013	broad.mit.edu	37	2	135621102	135621102	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:135621102G>T	uc002ttz.2	+	5	454	c.387G>T	c.(385-387)ATG>ATT	p.M129I	ACMSD_uc002tua.2_Missense_Mutation_p.M71I	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	129					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		TCAAGGAGATGGAGCGCTGTG	0.607													21	25					7.45023e-12	7.50761e-12	1	1	0
YSK4	80122	broad.mit.edu	37	2	135756462	135756462	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:135756462G>A	uc002tue.1	-	5	451	c.420C>T	c.(418-420)CCC>CCT	p.P140P	YSK4_uc010fne.1_Silent_p.P112P|YSK4_uc002tuf.1_Silent_p.P140P|YSK4_uc010fnc.1_Silent_p.P140P|YSK4_uc010fnd.1_Intron|YSK4_uc010zbg.1_Silent_p.P140P|YSK4_uc002tui.3_Silent_p.P157P	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	140							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GCAAAACTAAGGGCCGCATGG	0.433													18	25					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135890479	135890479	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:135890479T>A	uc002tuj.2	+	14	1276	c.1251T>A	c.(1249-1251)GAT>GAA	p.D417E	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.D417E|RAB3GAP1_uc010fng.2_Missense_Mutation_p.D242E|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	417						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		TATTCCCTGATGCTGTTTCTG	0.308													18	31					0	0	1	0	0
DARS	1615	broad.mit.edu	37	2	136691503	136691503	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:136691503G>A	uc002tux.1	-	6	665	c.481C>T	c.(481-483)CGG>TGG	p.R161W	DARS_uc010fnj.1_Missense_Mutation_p.R61W	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	161					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	GCCTCAGGCCGAACAGCATCA	0.388													14	19					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141110552	141110552	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:141110552G>A	uc002tvj.1	-	76	12592	c.11620C>T	c.(11620-11622)CAA>TAA	p.Q3874*		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3874	Extracellular (Potential).|EGF-like 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTCTTTCTTGAAAATTCTGG	0.313										TSP Lung(27;0.18)			29	43					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142012091	142012091	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:142012091C>T	uc002tvj.1	-	4	1435	c.463G>A	c.(463-465)GAT>AAT	p.D155N	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	155	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTTACTTACCTTTACAGCTT	0.363										TSP Lung(27;0.18)			11	27					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155158006	155158006	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:155158006C>T	uc002tyr.3	+	9	1627	c.1060C>T	c.(1060-1062)CCT>TCT	p.P354S	GALNT13_uc002tyt.3_Missense_Mutation_p.P354S|GALNT13_uc010foc.1_Missense_Mutation_p.P173S|GALNT13_uc010fod.2_Missense_Mutation_p.P107S	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	354	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						ATACACTTTTCCTGGTGGCAC	0.438													26	77					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155295205	155295205	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:155295205G>A	uc002tyr.3	+	12	2064	c.1497G>A	c.(1495-1497)ATG>ATA	p.M499I	GALNT13_uc002tyt.3_Missense_Mutation_p.M499I|GALNT13_uc010fod.2_Missense_Mutation_p.E232K|uc002tyu.1_Intron	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	499	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GCCACCATATGAGAGGAAATC	0.333													24	34					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160031580	160031580	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:160031580C>T	uc002uag.2	+	12	1894	c.1620C>T	c.(1618-1620)GAC>GAT	p.D540D	TANC1_uc010fol.1_Silent_p.D434D|TANC1_uc010zcm.1_Silent_p.D532D|TANC1_uc010fom.1_Silent_p.D346D|TANC1_uc002uai.1_5'Flank	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	540						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CCTACAGAGACCTTCTGATAA	0.592													49	75					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160294897	160294897	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:160294897G>A	uc002uao.2	-	8	1562	c.1210C>T	c.(1210-1212)CCT>TCT	p.P404S	BAZ2B_uc002uap.2_Missense_Mutation_p.P402S|BAZ2B_uc002uas.1_Missense_Mutation_p.P341S|BAZ2B_uc002uau.1_Missense_Mutation_p.P402S|BAZ2B_uc002uaq.1_Missense_Mutation_p.P332S|BAZ2B_uc002uat.3_3'UTR|BAZ2B_uc010fop.1_Missense_Mutation_p.P402S	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TCAGGAGAAGGAACTATGAGT	0.363													15	26					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163059615	163059615	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:163059615G>A	uc002ucd.2	-	13	1296	c.1088C>T	c.(1087-1089)TCG>TTG	p.S363L	FAP_uc010zct.1_Missense_Mutation_p.S338L|FAP_uc010fpd.2_Intron	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	363	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						TTTGTAGTACGAAATGGCATC	0.333													3	15					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163374645	163374645	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:163374645G>A	uc002uch.1	-	4	699	c.487C>T	c.(487-489)CCT>TCT	p.P163S	KCNH7_uc002uci.2_Missense_Mutation_p.P163S	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	163	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	CTCAGACCAGGGAATTTGAAC	0.393													31	47					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	167760034	167760034	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:167760034G>A	uc002udx.2	+	1	60	c.42G>A	c.(40-42)CAG>CAA	p.Q14Q	XIRP2_uc010fpn.2_Silent_p.Q14Q|XIRP2_uc010fpo.2_Silent_p.Q14Q|XIRP2_uc010fpp.2_Silent_p.Q14Q	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCCTGAGGCAGAAATGGGAAT	0.473													19	30					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168101452	168101452	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:168101452G>A	uc002udx.2	+	8	3568	c.3550G>A	c.(3550-3552)GAA>AAA	p.E1184K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E1009K|XIRP2_uc010fpq.2_Missense_Mutation_p.E962K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1009					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGAAGTGAAGGAAATCAAGCC	0.378													14	25					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102694	168102694	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:168102694G>A	uc002udx.2	+	8	4810	c.4792G>A	c.(4792-4794)GAA>AAA	p.E1598K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E1423K|XIRP2_uc010fpq.2_Missense_Mutation_p.E1376K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1423					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GATACAGAAAGAAGAAATTAT	0.393													15	16					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169939973	169939973	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:169939973C>T	uc002uep.2	+	6	1952	c.448C>T	c.(448-450)CCT>TCT	p.P150S	DHRS9_uc002ueq.2_Missense_Mutation_p.P150S|DHRS9_uc010zdc.1_Missense_Mutation_p.P210S|DHRS9_uc010zdd.1_Missense_Mutation_p.P150S|DHRS9_uc010zde.1_Missense_Mutation_p.P150S	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	150					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						AAATATGCTTCCTTTGGTCAA	0.483													22	37					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170002343	170002343	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:170002343C>T	uc002ues.2	-	70	13115	c.12902G>A	c.(12901-12903)GGG>GAG	p.G4301E		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4301	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTTTCCTTGCCCAAATTTATT	0.403													13	18					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170097679	170097679	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:170097679C>T	uc002ues.2	-	25	4077	c.3864G>A	c.(3862-3864)TGG>TGA	p.W1288*	LRP2_uc010zdf.1_Nonsense_Mutation_p.W1151*	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1288	LDL-receptor class A 14.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GATCACAGAGCCATGCCCTGT	0.527													30	62					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171243660	171243660	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:171243660C>T	uc002ufy.2	+	14	1562	c.1419C>T	c.(1417-1419)TCC>TCT	p.S473S	MYO3B_uc002ufv.2_Silent_p.S460S|MYO3B_uc010fqb.1_Silent_p.S460S|MYO3B_uc002ufz.2_Silent_p.S473S|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	473	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						AAGTCAACTCCCTGGTGGAAG	0.443													20	31					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171248040	171248040	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:171248040A>C	uc002ufy.2	+	15	1731	c.1588A>C	c.(1588-1590)AAT>CAT	p.N530H	MYO3B_uc002ufv.2_Missense_Mutation_p.N517H|MYO3B_uc010fqb.1_Missense_Mutation_p.N517H|MYO3B_uc002ufz.2_Missense_Mutation_p.N530H|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	530	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GAGAGAGAAAAATTTTCATAT	0.328													8	12					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173891334	173891334	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:173891334G>A	uc002uhv.3	+	24	2475	c.2288G>A	c.(2287-2289)GGA>GAA	p.G763E	RAPGEF4_uc002uhw.3_Missense_Mutation_p.G619E	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	763					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CCAACTGTTGGAACAGTGGGA	0.393													15	23					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179435844	179435844	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179435844G>A	uc010zfg.1	-	275	67535	c.67311C>T	c.(67309-67311)GAC>GAT	p.D22437D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.D16132D|TTN_uc010zfi.1_Silent_p.D16065D|TTN_uc010zfj.1_Silent_p.D15940D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23364							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATCACATGGGTCACGAGCCA	0.473													52	71					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179439686	179439686	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179439686C>T	uc010zfg.1	-	275	63693	c.63469G>A	c.(63469-63471)GAT>AAT	p.D21157N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D14852N|TTN_uc010zfi.1_Missense_Mutation_p.D14785N|TTN_uc010zfj.1_Missense_Mutation_p.D14660N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22084							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTGGGATATCATGGACTTGA	0.443													10	15					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179440965	179440965	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179440965G>A	uc010zfg.1	-	275	62414	c.62190C>T	c.(62188-62190)ATC>ATT	p.I20730I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.I14425I|TTN_uc010zfi.1_Silent_p.I14358I|TTN_uc010zfj.1_Silent_p.I14233I|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21657							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGAACTGAGTGATTCTGAGGG	0.463													14	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179446723	179446723	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179446723C>T	uc010zfg.1	-	264	58893	c.58669G>A	c.(58669-58671)GAA>AAA	p.E19557K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E13252K|TTN_uc010zfi.1_Missense_Mutation_p.E13185K|TTN_uc010zfj.1_Missense_Mutation_p.E13060K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20484							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTCATATTCGGTACCTTCT	0.453													36	67					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179455074	179455074	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179455074C>T	uc010zfg.1	-	253	53898	c.53674G>A	c.(53674-53676)GAA>AAA	p.E17892K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E11587K|TTN_uc010zfi.1_Missense_Mutation_p.E11520K|TTN_uc010zfj.1_Missense_Mutation_p.E11395K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18819							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGCTAGTTCTCTTGGCTCA	0.418													31	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179463874	179463874	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179463874G>A	uc010zfg.1	-	239	49166	c.48942C>T	c.(48940-48942)TTC>TTT	p.F16314F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.F10009F|TTN_uc010zfi.1_Silent_p.F9942F|TTN_uc010zfj.1_Silent_p.F9817F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17241							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTACTTACAGAAGAGGTTTC	0.368													93	132					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179500317	179500317	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179500317C>T	uc010zfg.1	-	176	34254	c.34030G>A	c.(34030-34032)GAA>AAA	p.E11344K	TTN_uc010zfh.1_Missense_Mutation_p.E5039K|TTN_uc010zfi.1_Missense_Mutation_p.E4972K|TTN_uc010zfj.1_Missense_Mutation_p.E4847K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12271							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAGGGATTTCATCATATCCT	0.388													4	7					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179531961	179531961	+	Splice_Site	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179531961A>G	uc010zfk.1	-	8	867	c.319_splice	c.e8+1	p.E107_splice	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGAATTATACCTTCAGTTG	0.343													3	5					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179592079	179592079	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179592079C>T	uc010zfg.1	-	66	16505	c.16281G>A	c.(16279-16281)AAG>AAA	p.K5427K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.K2088K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6354							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTAATTTCTTTACAAACT	0.383													10	13					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179616027	179616027	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179616027C>T	uc002unb.2	-	46	11324	c.11100G>A	c.(11098-11100)GTG>GTA	p.V3700V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGCAACTTCACTTTGGTCT	0.333													16	51					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179622408	179622408	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:179622408G>A	uc010zfi.1	-	44	10625	c.10401C>T	c.(10399-10401)TTC>TTT	p.F3467F	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc002unb.2_Intron	NM_133432	NP_597676	Q8WZ42	TITIN_HUMAN	titin isoform novex-1	3551							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCAAAATGGAAAACTACAT	0.448													35	49					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182394310	182394310	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:182394310G>A	uc002unu.2	+	23	3236	c.2473G>A	c.(2473-2475)GAA>AAA	p.E825K	ITGA4_uc002unv.2_Missense_Mutation_p.E70K	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	825	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TGTTAGTGTGGAAATAATGGT	0.318													17	22					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183104880	183104880	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:183104880G>A	uc002uos.2	-	4	439	c.355C>T	c.(355-357)CGG>TGG	p.R119W	PDE1A_uc010zfp.1_Missense_Mutation_p.R15W|PDE1A_uc002uoq.1_Missense_Mutation_p.R119W|PDE1A_uc010zfq.1_Missense_Mutation_p.R119W|PDE1A_uc002uor.2_Missense_Mutation_p.R103W|PDE1A_uc002uou.2_Missense_Mutation_p.R85W	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	119					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			ACAATGCTCCGAAATTTTGGT	0.418													43	46					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802413	185802413	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:185802413G>A	uc002uph.2	+	4	2884	c.2290G>A	c.(2290-2292)GAA>AAA	p.E764K		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	764						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TGTCATGAATGAATCAGAAAG	0.333													21	39					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802718	185802718	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:185802718C>T	uc002uph.2	+	4	3189	c.2595C>T	c.(2593-2595)ATC>ATT	p.I865I		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	865						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TTGCAAAAATCGAAAGGAACT	0.358													21	23					0	0	1	0	0
TFPI	7035	broad.mit.edu	37	2	188332650	188332650	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:188332650C>T	uc002upx.2	-	7	671	c.638G>A	c.(637-639)GGT>GAT	p.G213D	TFPI_uc002upy.2_Missense_Mutation_p.G213D|TFPI_uc002upz.2_Missense_Mutation_p.G209D	NM_006287	NP_006278	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor isoform a	213					blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	CCATGAGGGACCGTGAAATTC	0.393													12	22					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189839238	189839238	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:189839238G>A	uc002uqj.1	+	1	140	c.23G>A	c.(22-24)GGG>GAG	p.G8E		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	8					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GTGCAAAAGGGGAGCTGGCTA	0.398													12	31					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189849651	189849651	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:189849651G>A	uc002uqj.1	+	2	362	c.245G>A	c.(244-246)GGA>GAA	p.G82E		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	82	VWFC.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	ATTCCATTTGGAGAATGTTGT	0.408													22	25					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189872648	189872648	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:189872648G>A	uc002uqj.1	+	46	3518	c.3401G>A	c.(3400-3402)GGA>GAA	p.G1134E		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1134	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGCAGTCCAGGACCTGCAGGC	0.473													37	65					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189873725	189873725	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:189873725G>A	uc002uqj.1	+	48	3718	c.3601G>A	c.(3601-3603)GGA>AGA	p.G1201R		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1201	Nonhelical region (C-terminal).				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGGTGGTGTTGGAGCCGCTGC	0.542													22	31					0	0	1	0	0
MSTN	2660	broad.mit.edu	37	2	190924968	190924968	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:190924968G>A	uc002urp.2	-	2	700	c.567C>T	c.(565-567)ATC>ATT	p.I189I		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	189					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TCAGAGATCGGATTCCAGTAT	0.428													27	39					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192701219	192701219	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:192701219C>T	uc002utb.2	-	2	1038	c.708G>A	c.(706-708)CTG>CTA	p.L236L		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	236	Potential.					caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CCACTTTCTTCAGGCTGGATC	0.468													76	89					0	0	1	0	0
TMEFF2	23671	broad.mit.edu	37	2	192863813	192863813	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:192863813C>T	uc002utc.2	-	6	1052	c.658G>A	c.(658-660)GAA>AAA	p.E220K		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	220	Kazal-like 2.|Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			GACATGACTTCAATTTTCTCC	0.358													28	49					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196682511	196682511	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:196682511C>T	uc002utj.3	-	50	9435	c.9334G>A	c.(9334-9336)GAT>AAT	p.D3112N		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3112	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGAAGCTGATCTTGCATTCCC	0.333													17	20					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196729357	196729357	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:196729357C>T	uc002utj.3	-	41	7123	c.7022G>A	c.(7021-7023)GGG>GAG	p.G2341E		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2341	ATP (Potential).|AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CCCTCCAACCCCTACTAGGAG	0.468													20	33					0	0	1	0	0
CASP8	841	broad.mit.edu	37	2	202149821	202149821	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:202149821G>A	uc002uxr.1	+	9	1294	c.1085G>A	c.(1084-1086)GGG>GAG	p.G362E	CASP8_uc002uxp.1_Missense_Mutation_p.G379E|CASP8_uc002uxq.1_Missense_Mutation_p.G347E|CASP8_uc002uxt.1_Missense_Mutation_p.G421E|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Missense_Mutation_p.G347E|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Missense_Mutation_p.G278E	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	362					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GCTTGTCAGGGGGATAACTAC	0.448										HNSCC(4;0.00038)			29	53					0	0	1	0	0
ALS2CR4	65062	broad.mit.edu	37	2	202492833	202492833	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:202492833A>T	uc002uyh.1	-	11	1010	c.909T>A	c.(907-909)TTT>TTA	p.F303L	ALS2CR4_uc002uyg.1_Missense_Mutation_p.F295L|ALS2CR4_uc010zho.1_Missense_Mutation_p.F98L	NM_001044385	NP_001037850	Q96Q45	TM237_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	327	Helical; (Potential).					integral to membrane	protein binding				0						CCAGGGCCAAAAAATTTCGGA	0.333													6	13					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202580434	202580434	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:202580434G>A	uc002uyo.2	-	25	4321	c.3965C>T	c.(3964-3966)GCT>GTT	p.A1322V	ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	1322					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						CAAGGCCACAGCAATATTGTC	0.532													56	62					0	0	1	0	0
WDR12	55759	broad.mit.edu	37	2	203759326	203759326	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:203759326C>T	uc002uzl.2	-	7	1383	c.633G>A	c.(631-633)AAG>AAA	p.K211K	WDR12_uc010ftt.2_Silent_p.K211K	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	211	WD 3.|Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						TCTTTAGCATCTTATCCCAGG	0.299													97	123					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	205990428	205990428	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:205990428C>T	uc002var.1	+	10	1608	c.1401C>T	c.(1399-1401)GCC>GCT	p.A467A	PARD3B_uc010fub.1_Silent_p.A467A|PARD3B_uc002vao.1_Silent_p.A467A|PARD3B_uc002vap.1_Silent_p.A467A|PARD3B_uc002vaq.1_Silent_p.A467A	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	467	PDZ 2.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TGGTCATTGCCCGCCAAGAAG	0.488													29	58					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206874380	206874380	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:206874380G>A	uc002vaz.3	-	9	2086	c.1681C>T	c.(1681-1683)CCC>TCC	p.P561S		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	561					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GGTGGAATGGGTTTTTGGGGT	0.577													26	43					0	0	1	0	0
ADAM23	8745	broad.mit.edu	37	2	207414845	207414845	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:207414845G>A	uc002vbq.2	+	9	1117	c.894G>A	c.(892-894)ATG>ATA	p.M298I	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	298	Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TTGAAGAAATGAAATATTTGG	0.303													11	22					0	0	1	0	0
ADAM23	8745	broad.mit.edu	37	2	207457427	207457427	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:207457427C>T	uc002vbq.2	+	22	2268	c.2045C>T	c.(2044-2046)TCC>TTC	p.S682F	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	682	Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		ATTCCAACTTCCTTCTACCAT	0.383													18	40					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210574799	210574799	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:210574799C>T	uc002vde.1	+	12	5142	c.4894C>T	c.(4894-4896)CCC>TCC	p.P1632S	MAP2_uc002vdd.1_Missense_Mutation_p.P333S|MAP2_uc002vdf.1_Missense_Mutation_p.P276S|MAP2_uc002vdg.1_Missense_Mutation_p.P276S|MAP2_uc002vdh.1_Missense_Mutation_p.P333S|MAP2_uc002vdi.1_Missense_Mutation_p.P1628S	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1632					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	ACCAGGAACCCCCAAGTCTGC	0.552													30	52					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212587164	212587164	+	Silent	SNP	G	A	A	rs151042332		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:212587164G>A	uc002veg.1	-	7	935	c.837C>T	c.(835-837)TTC>TTT	p.F279F	ERBB4_uc002veh.1_Silent_p.F279F|ERBB4_uc010zji.1_Silent_p.F279F|ERBB4_uc010zjj.1_Silent_p.F279F|ERBB4_uc010fut.1_Silent_p.F279F	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	279	Cys-rich.|Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ACTTTGCATTGAAATTGTGCT	0.378										TSP Lung(8;0.080)			12	15					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215279072	215279072	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:215279072G>A	uc002vet.2	+	2	285	c.155G>A	c.(154-156)GGG>GAG	p.G52E	VWC2L_uc010zjl.1_Missense_Mutation_p.G52E	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	52	VWFC 1.					extracellular region					0						CGAGGGAAAGGGTGTGTCGAT	0.473													9	18					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215279114	215279114	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:215279114G>A	uc002vet.2	+	2	327	c.197G>A	c.(196-198)CGA>CAA	p.R66Q	VWC2L_uc010zjl.1_Missense_Mutation_p.R66Q	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	66	VWFC 1.					extracellular region					0						TTGGGAGAACGATTTTTCCCT	0.458													6	20					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219247685	219247685	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:219247685G>A	uc002vhv.2	+	2	350	c.10G>A	c.(10-12)GAC>AAC	p.D4N	SLC11A1_uc010zkb.1_Missense_Mutation_p.D4N|SLC11A1_uc010fvp.1_Missense_Mutation_p.D4N|SLC11A1_uc010fvq.1_Intron|SLC11A1_uc010zkc.1_5'UTR|SLC11A1_uc002vhu.1_5'UTR|SLC11A1_uc002vhw.2_5'UTR	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	4	Pro/Ser-rich.|Cytoplasmic (Potential).				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCCACAGGTGACAAGGGTCC	0.517													34	52					0	0	1	0	0
RNF25	64320	broad.mit.edu	37	2	219528925	219528925	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:219528925G>A	uc002vit.2	-	10	1223	c.1135C>T	c.(1135-1137)CTC>TTC	p.L379F	RNF25_uc010fvw.2_Missense_Mutation_p.L267F	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	379					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCTCCTTGAGGGGCCCCTCA	0.657													60	105					0	0	1	0	0
PRKAG3	53632	broad.mit.edu	37	2	219694934	219694934	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:219694934C>T	uc002vjb.1	-	4	419	c.400G>A	c.(400-402)GAG>AAG	p.E134K	PRKAG3_uc010zkn.1_RNA|PRKAG3_uc010fvy.1_Missense_Mutation_p.E134K|PRKAG3_uc010zko.1_Missense_Mutation_p.E130K	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	134					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGGCCAGCTCCACATCATCT	0.642													17	22					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220472776	220472776	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:220472776C>T	uc002vml.2	+	14	1303	c.1260C>T	c.(1258-1260)TTC>TTT	p.F420F	STK11IP_uc010zll.1_Silent_p.F377F|STK11IP_uc002vmm.1_Silent_p.F409F	NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	420					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAGGATGGTTCGTGCAGCAGC	0.627													12	25					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220505162	220505162	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:220505162C>T	uc002vmp.3	+	21	3557	c.3288C>T	c.(3286-3288)ATC>ATT	p.I1096I	SLC4A3_uc002vmo.3_Silent_p.I1123I|SLC4A3_uc010fwm.2_Silent_p.I646I	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	1096	Helical; (Potential).|Membrane (anion exchange).			I -> M (in Ref. 2; AAB05850).	bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCTGTCCATCGTCATGGGGG	0.617													21	41					0	0	1	0	0
ACSL3	2181	broad.mit.edu	37	2	223786022	223786022	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:223786022T>C	uc002vni.2	+	8	1281	c.830T>C	c.(829-831)TTG>TCG	p.L277S	ACSL3_uc002vnj.2_Missense_Mutation_p.L277S	NM_004457	NP_004448	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	277	Cytoplasmic (Potential).				long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			ovary(2)	2		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	AGCAAACCATTGCCCTCAGAT	0.378			T	ETV1	prostate								33	34					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227922301	227922301	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:227922301G>A	uc010zlt.1	-	29	3053	c.2399C>T	c.(2398-2400)CCT>CTT	p.P800L		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	800	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TAGGAATCCAGGAATGCCAGC	0.478													8	23					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228109668	228109668	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:228109668G>A	uc002vom.1	+	5	443	c.281G>A	c.(280-282)GGA>GAA	p.G94E	COL4A3_uc002von.1_Missense_Mutation_p.G94E|COL4A3_uc002voo.1_Missense_Mutation_p.G94E|COL4A3_uc002vop.1_Missense_Mutation_p.G94E|uc002voq.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	94	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TGTCTTCAGGGAATAAGTGGA	0.313													48	56					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883106	228883106	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:228883106C>T	uc002vpq.2	-	7	2511	c.2464G>A	c.(2464-2466)GAT>AAT	p.D822N	SPHKAP_uc002vpp.2_Missense_Mutation_p.D822N|SPHKAP_uc010zlx.1_Missense_Mutation_p.D822N	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	822						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GTTGAAGAATCGGGCACTCTG	0.468													41	53					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230911095	230911095	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:230911095C>T	uc002vqd.1	-	4	1110	c.747G>A	c.(745-747)AAG>AAA	p.K249K	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Silent_p.K249K|SLC16A14_uc002vqf.2_Silent_p.K249K	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	249	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		GCCCACCATCCTTCTCTTCTG	0.587													41	74					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230923874	230923874	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:230923874G>A	uc002vqd.1	-	2	558	c.195C>T	c.(193-195)TTC>TTT	p.F65F	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Silent_p.F65F|SLC16A14_uc002vqf.2_Silent_p.F65F	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	65	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		GGCTCTGGTGGAATTCTTCCA	0.557													26	43					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231106164	231106164	+	Nonsense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:231106164T>G	uc002vql.2	+	4	567	c.452T>G	c.(451-453)TTA>TGA	p.L151*	SP140_uc010zma.1_RNA|SP140_uc002vqk.2_Nonsense_Mutation_p.L151*|SP140_uc002vqn.2_Nonsense_Mutation_p.L151*|SP140_uc002vqm.2_Nonsense_Mutation_p.L151*|SP140_uc010fxl.2_Nonsense_Mutation_p.L151*	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	151					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GTAAACGATTTAGAAGATAGA	0.383													9	15					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231222634	231222634	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:231222634C>T	uc010fxm.1	+	3	313	c.222C>T	c.(220-222)TTC>TTT	p.F74F	SP140_uc010zma.1_RNA|SP140L_uc010fxn.1_5'UTR	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	74	HSR.					nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1						CATTTCCATTCCTTGAGGGCC	0.373													61	76					0	0	1	0	0
DIS3L2	129563	broad.mit.edu	37	2	233028322	233028322	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:233028322C>T	uc010fxz.2	+	9	1380	c.1104C>T	c.(1102-1104)TTC>TTT	p.F368F	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	368							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CAGAGGAGTTCAGCAAGAGAA	0.433													12	18					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233272986	233272986	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:233272986G>A	uc002vss.3	+	6	711	c.658G>A	c.(658-660)GGT>AGT	p.G220S		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	220					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GGTGATCCTAGGTGGAGGCCG	0.622													33	59					0	0	1	0	0
CXCR7	57007	broad.mit.edu	37	2	237489211	237489211	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:237489211C>T	uc010fyq.2	+	3	333	c.103C>T	c.(103-105)CCC>TCC	p.P35S	CXCR7_uc002vwd.2_Missense_Mutation_p.P35S	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	35	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)		GGTGATGTGTCCCAACATGCC	0.532													16	19					0	0	1	0	0
MLPH	79083	broad.mit.edu	37	2	238449466	238449466	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:238449466A>T	uc002vwt.2	+	11	1539	c.1312A>T	c.(1312-1314)ACC>TCC	p.T438S	MLPH_uc002vws.2_Missense_Mutation_p.T295S|MLPH_uc010fyt.1_Missense_Mutation_p.T410S|MLPH_uc002vwu.2_Missense_Mutation_p.T410S|MLPH_uc002vwv.2_Intron|MLPH_uc002vww.2_Intron|MLPH_uc002vwx.2_Missense_Mutation_p.T294S|MLPH_uc010fyu.2_Missense_Mutation_p.T190S	NM_024101	NP_077006	Q9BV36	MELPH_HUMAN	melanophilin isoform 1	438	Potential.						metal ion binding			ovary(1)	1		Breast(86;0.000381)|Renal(207;0.000966)|Ovarian(221;0.0695)|all_hematologic(139;0.095)|all_lung(227;0.17)|Melanoma(123;0.203)		Epithelial(121;1.17e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.02e-10)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.15e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000439)|Lung(119;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0316)		TGCCCATCAAACCAACAGACA	0.592													8	18					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240029877	240029877	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:240029877G>A	uc002vyk.3	-	15	2758	c.1966C>T	c.(1966-1968)CTC>TTC	p.L656F	HDAC4_uc010fyz.1_Missense_Mutation_p.L651F|HDAC4_uc010zoa.1_Missense_Mutation_p.L656F|HDAC4_uc010fza.2_Missense_Mutation_p.L661F|HDAC4_uc010fyy.2_Missense_Mutation_p.L613F|HDAC4_uc010znz.1_Missense_Mutation_p.L539F	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	656	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		TCATACACGAGGCCTGGGGCG	0.687													4	6					0	0	1	0	0
NDUFA10	4705	broad.mit.edu	37	2	240929550	240929550	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:240929550G>A	uc002vyn.2	-	9	1020	c.940C>T	c.(940-942)CTC>TTC	p.L314F	NDUFA10_uc010fzc.1_Missense_Mutation_p.L344F	NM_004544	NP_004535	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	314					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)	1		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	ACTTCCGGGAGAAAGATAGGA	0.423													35	33					0	0	1	0	0
MYEOV2	150678	broad.mit.edu	37	2	241069367	241069367	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:241069367G>A	uc002vyu.1	-	4	342	c.342C>T	c.(340-342)GTC>GTT	p.V114V		NM_138336	NP_612209	Q8WXC6	MYOV2_HUMAN	hypothetical protein LOC150678 isoform 1	Error:Variant_position_missing_in_Q8WXC6_after_alignment											0		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		CCTTCCCACGGACCCCGTGCT	0.627													27	43					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242194856	242194856	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:242194856G>A	uc002waz.2	-	8	1241	c.1013C>T	c.(1012-1014)TCT>TTT	p.S338F	HDLBP_uc002wba.2_Missense_Mutation_p.S338F|HDLBP_uc002wbb.2_Intron|HDLBP_uc010fzn.1_Missense_Mutation_p.S67F	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	338	KH 3.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TACAGTCTCAGAGATGCTGTC	0.493													21	37					0	0	1	0	0
ING5	84289	broad.mit.edu	37	2	242648673	242648673	+	Missense_Mutation	SNP	C	T	T	rs148805882	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:242648673C>T	uc002wcd.2	+	3	177	c.152C>T	c.(151-153)TCC>TTC	p.S51F	ING5_uc002wcc.1_Missense_Mutation_p.S51F	NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	51					DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		GAGTACATCTCCACGGTGAAG	0.473													66	90					0	0	1	0	0
RBCK1	10616	broad.mit.edu	37	20	411013	411013	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:411013G>A	uc002wdp.3	+	12	2165	c.1472G>A	c.(1471-1473)GGG>GAG	p.G491E	RBCK1_uc002wdq.3_Missense_Mutation_p.G449E|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Missense_Mutation_p.G321E	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	491					interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				GACACCAGCGGGGGCTGCCGC	0.632													13	25					0	0	1	0	0
ANGPT4	51378	broad.mit.edu	37	20	896668	896668	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:896668C>T	uc002wei.2	-	1	293	c.190G>A	c.(190-192)GAC>AAC	p.D64N	ANGPT4_uc010zpn.1_Missense_Mutation_p.D58N	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	64					anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						GTGTTGGAGTCCCTGGAGACC	0.607													43	50					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1617024	1617024	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:1617024C>T	uc002wfm.1	-	3	623	c.558G>A	c.(556-558)GGG>GGA	p.G186G	SIRPG_uc002wfn.1_Silent_p.G186G|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	186	Extracellular (Potential).|Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						AGAGCTCATTCCCATTTTTGA	0.577													27	58					0	0	1	0	0
VPS16	64601	broad.mit.edu	37	20	2840755	2840755	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:2840755C>T	uc002whe.2	+	3	246	c.198C>T	c.(196-198)CTC>CTT	p.L66L	VPS16_uc002whh.2_5'Flank|VPS16_uc002whf.2_Silent_p.L66L|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	66					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						GGCCAGTGCTCGATATATACT	0.592													27	40					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3686517	3686517	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:3686517T>C	uc002wja.2	-	3	580	c.580A>G	c.(580-582)ACC>GCC	p.T194A	SIGLEC1_uc002wiz.3_Missense_Mutation_p.T194A|SIGLEC1_uc002wjc.2_Missense_Mutation_p.T105A	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	194	Ig-like C2-type 1.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CCGACGCCGGTGGGCTCAAAC	0.642													25	56					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5283051	5283051	+	Missense_Mutation	SNP	G	A	A	rs148868355	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:5283051G>A	uc010zqw.1	-	2	790	c.790C>T	c.(790-792)CGC>TGC	p.R264C	PROKR2_uc010zqx.1_Missense_Mutation_p.R264C|PROKR2_uc010zqy.1_Missense_Mutation_p.R264C	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	264	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						AGCCGCTTGCGAATCTGCTCC	0.612										HNSCC(71;0.22)			17	21					0	0	1	0	0
GPCPD1	56261	broad.mit.edu	37	20	5556488	5556488	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:5556488G>A	uc002wme.3	-	9	1055	c.842C>T	c.(841-843)TCC>TTC	p.S281F	GPCPD1_uc002wmd.3_Missense_Mutation_p.S100F	NM_019593	NP_062539	Q9NPB8	GPCP1_HUMAN	hypothetical protein LOC56261	281					glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0						TGTTTTCCGGGAATTTCTGCT	0.393													23	36					0	0	1	0	0
TRMT6	51605	broad.mit.edu	37	20	5927167	5927167	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:5927167G>A	uc002wmh.1	-	2	263	c.141C>T	c.(139-141)TTC>TTT	p.F47F	TRMT6_uc010zra.1_5'UTR|TRMT6_uc010gbn.1_5'UTR|TRMT6_uc010gbo.1_RNA	NM_015939	NP_057023	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6	47					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			pancreas(1)	1						ACTGTTTTTCGAAAGTTACTT	0.373													12	36					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8770910	8770910	+	Splice_Site	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:8770910T>A	uc002wnb.2	+	31	3426	c.3423_splice	c.e31+2	p.K1141_splice	PLCB1_uc002wna.2_Splice_Site_p.K1141_splice	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1						activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AAGCCCAAGGTAAACGGAACT	0.358													5	0					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9520219	9520219	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:9520219C>T	uc002wnl.2	-	11	2595	c.2050G>A	c.(2050-2052)GAG>AAG	p.E684K	PAK7_uc002wnk.2_Missense_Mutation_p.E684K|PAK7_uc002wnj.2_Missense_Mutation_p.E684K|PAK7_uc010gby.1_Missense_Mutation_p.E597K	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	684	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TGAGAGGGCTCCCTCACCAAC	0.507													64	92					0	0	1	0	0
SEL1L2	80343	broad.mit.edu	37	20	13850827	13850827	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:13850827C>T	uc010gcf.2	-	13	1209	c.1127G>A	c.(1126-1128)GGG>GAG	p.G376E	SEL1L2_uc002woq.3_Missense_Mutation_p.G237E|SEL1L2_uc010zrl.1_Missense_Mutation_p.G376E|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	376	Extracellular (Potential).|Sel1-like 7.					integral to membrane	binding			ovary(2)	2						AAGACCAAGCCCATGAAGGCC	0.328													18	40					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	15967437	15967437	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:15967437G>A	uc002wou.2	+	14	1315	c.1051G>A	c.(1051-1053)GAA>AAA	p.E351K	MACROD2_uc002wot.2_Missense_Mutation_p.E351K|MACROD2_uc002woz.2_Missense_Mutation_p.E116K|MACROD2_uc002wpb.2_Missense_Mutation_p.E116K|MACROD2_uc002wpd.2_Missense_Mutation_p.E2K	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1	351	Glu-rich.										0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				CTCATATATGGAAACAGAAGG	0.274													6	15					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20527471	20527471	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:20527471G>A	uc002wrz.2	-	24	3305	c.3162C>T	c.(3160-3162)ATC>ATT	p.I1054I	RALGAPA2_uc010gcx.2_Silent_p.I758I|RALGAPA2_uc010zsg.1_Silent_p.I502I	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1054					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						TCGTATTTAAGATATCCTAAA	0.428													12	14					0	0	1	0	0
SSTR4	6754	broad.mit.edu	37	20	23017262	23017262	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:23017262C>T	uc002wsr.2	+	1	1206	c.1142C>T	c.(1141-1143)CCC>CTC	p.P381L		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	381	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					AAGCGCATCCCCCTCACCAGG	0.667													21	28					0	0	1	0	0
CST9	128822	broad.mit.edu	37	20	23584308	23584308	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:23584308C>T	uc002wtl.2	-	2	428	c.319G>A	c.(319-321)GAA>AAA	p.E107K		NM_001008693	NP_001008693	Q5W186	CST9_HUMAN	cystatin 9 precursor	107						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Colorectal(13;0.0993)					ATGTCATCTTCAAATTTCCTA	0.473													55	82					0	0	1	0	0
C20orf191	149934	broad.mit.edu	37	20	26084304	26084304	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:26084304G>A	uc002wvj.3	-	2	167	c.112C>T	c.(112-114)CCA>TCA	p.P38S		NR_003678				SubName: Full=Putative uncharacterized protein ENSP00000323172;												0						CCAAATGCTGGATCCTTTAGA	0.393													6	32					0	0	1	0	0
REM1	28954	broad.mit.edu	37	20	30065650	30065650	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:30065650C>T	uc002wwa.2	+	3	644	c.360C>T	c.(358-360)ACC>ACT	p.T120T		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	120					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			ATGAGAGGACCCTCACGGTGG	0.582													11	12					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30585011	30585011	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:30585011C>T	uc002wxe.2	+	3	1665	c.1491C>T	c.(1489-1491)ACC>ACT	p.T497T		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	497						integral to membrane		p.T497T(1)		ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GGACCCCCACCCCACCTGTCT	0.682													17	28					0	0	1	0	0
PLAGL2	5326	broad.mit.edu	37	20	30784309	30784309	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:30784309G>A	uc002wxn.2	-	3	1654	c.1437C>T	c.(1435-1437)TTC>TTT	p.F479F		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	479						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGCCAGACGTGAAGACAGGAG	0.577													26	34					0	0	1	0	0
PLAGL2	5326	broad.mit.edu	37	20	30784649	30784649	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:30784649A>T	uc002wxn.2	-	3	1314	c.1097T>A	c.(1096-1098)CTT>CAT	p.L366H		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	366						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCTTCCAGGAAGCTCCGCCAG	0.582													16	26					0	0	1	0	0
SLA2	84174	broad.mit.edu	37	20	35262025	35262025	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:35262025C>T	uc002xfv.2	-	4	561	c.199G>A	c.(199-201)GAC>AAC	p.D67N	SLA2_uc002xfu.2_Missense_Mutation_p.D67N	NM_032214	NP_115590	Q9H6Q3	SLAP2_HUMAN	Src-like-adaptor 2 isoform a	67	SH3.				antigen receptor-mediated signaling pathway|B cell mediated immunity|intracellular receptor mediated signaling pathway|negative regulation of B cell activation|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|T cell activation	cytoplasmic membrane-bounded vesicle|endosome membrane|plasma membrane	protein N-terminus binding|SH3/SH2 adaptor activity				0	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				GTCCACCAGTCTCCATCCCTG	0.597													22	25					0	0	1	0	0
C20orf132	140699	broad.mit.edu	37	20	35783561	35783561	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:35783561G>A	uc010zvu.1	-	11	1100	c.1009C>T	c.(1009-1011)CCC>TCC	p.P337S	C20orf132_uc002xgk.2_Intron|C20orf132_uc002xgm.2_Missense_Mutation_p.P337S|C20orf132_uc002xgn.2_Intron	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Myeloproliferative disorder(115;0.00878)				TGTAACCAGGGGACCAAGTGC	0.463													47	60					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42331266	42331266	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:42331266C>T	uc002xlb.1	+	8	1303	c.1088C>T	c.(1087-1089)GCC>GTC	p.A363V	MYBL2_uc010zwj.1_Missense_Mutation_p.A339V|MYBL2_uc002xla.1_Missense_Mutation_p.A363V	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	363						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CAGCCTTCCGCCCTGGTGCCC	0.632													59	67					0	0	1	0	0
CD40	958	broad.mit.edu	37	20	44751838	44751838	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:44751838A>T	uc002xrg.1	+	5	554	c.477A>T	c.(475-477)GAA>GAT	p.E159D	CD40_uc002xrf.1_3'UTR|CD40_uc002xrh.1_Missense_Mutation_p.E159D|CD40_uc002xri.1_Missense_Mutation_p.E159D|CD40_uc002xrj.1_Intron|CD40_uc002xrk.1_Intron	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	159	TNFR-Cys 4.|Extracellular (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	CTGCTTTCGAAAAATGTCACC	0.537									Immune_Deficiency_with_Hyper-IgM				60	75					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47866189	47866189	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:47866189C>T	uc002xui.2	-	14	3619	c.3372G>A	c.(3370-3372)GAG>GAA	p.E1124E		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1124							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGCTTTTGCCCTCTTGGATTT	0.468													33	45					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	47990681	47990681	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:47990681C>T	uc002xur.1	-	2	1580	c.1416G>A	c.(1414-1416)ATG>ATA	p.M472I	KCNB1_uc002xus.1_Missense_Mutation_p.M472I	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	472	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTTTCTTACCCATATTCTCCC	0.423													43	62					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49212700	49212700	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:49212700G>A	uc002xvm.2	-	15	2197	c.1879C>T	c.(1879-1881)CAA>TAA	p.Q627*	FAM65C_uc010zyt.1_Nonsense_Mutation_p.Q631*|FAM65C_uc010zyu.1_RNA	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	627										ovary(2)	2						TTGCAGACTTGGAGGTGTACC	0.602													27	32					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56089711	56089711	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:56089711C>T	uc010gix.1	-	6	1929	c.1267G>A	c.(1267-1269)GAA>AAA	p.E423K	CTCFL_uc010giw.1_Missense_Mutation_p.E423K|CTCFL_uc002xym.2_Missense_Mutation_p.E423K|CTCFL_uc010giz.1_Missense_Mutation_p.E11K|CTCFL_uc010giy.1_Missense_Mutation_p.E93K|CTCFL_uc010gja.1_Intron|CTCFL_uc010gjb.1_Missense_Mutation_p.E423K|CTCFL_uc010gjc.1_Missense_Mutation_p.E423K|CTCFL_uc010gjd.1_Missense_Mutation_p.E423K|CTCFL_uc010gje.2_Missense_Mutation_p.E423K|CTCFL_uc010gjf.2_Missense_Mutation_p.E218K|CTCFL_uc010gjg.2_Missense_Mutation_p.E155K|CTCFL_uc010gjh.1_Intron|CTCFL_uc010gji.1_Missense_Mutation_p.E218K|CTCFL_uc010gjj.1_Missense_Mutation_p.E423K	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	423					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GGGACATTTTCGCCGTGTTTC	0.488											OREG0026065	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	62	91					0	0	1	0	0
ZBP1	81030	broad.mit.edu	37	20	56191374	56191374	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:56191374G>A	uc002xyo.2	-	2	466	c.185C>T	c.(184-186)TCC>TTC	p.S62F	ZBP1_uc010gjm.2_Missense_Mutation_p.S62F|ZBP1_uc002xyp.2_Intron|ZBP1_uc010zzn.1_Missense_Mutation_p.S62F	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	62	DRADA 1.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GGTGGCAGGGGATGTGAGGGA	0.597													22	47					0	0	1	0	0
C20orf151	140893	broad.mit.edu	37	20	60986024	60986024	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:60986024C>T	uc002ycw.1	-	14	2062	c.1905G>A	c.(1903-1905)AGG>AGA	p.R635R		NM_080833	NP_543023	Q8NC74	CT151_HUMAN	hypothetical protein LOC140893	635											0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;6.43e-06)			CTGTCAGTTTCCTTCTCCCTC	0.637													32	70					0	0	1	0	0
C20orf151	140893	broad.mit.edu	37	20	60989037	60989037	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:60989037T>G	uc002ycw.1	-	10	1527	c.1370A>C	c.(1369-1371)AAG>ACG	p.K457T		NM_080833	NP_543023	Q8NC74	CT151_HUMAN	hypothetical protein LOC140893	457											0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;6.43e-06)			GCCGGCCGGCTTGGGAGTGTC	0.726													4	8					0	0	1	0	0
C20orf151	140893	broad.mit.edu	37	20	60989205	60989205	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:60989205C>T	uc002ycw.1	-	10	1359	c.1202G>A	c.(1201-1203)GGG>GAG	p.G401E		NM_080833	NP_543023	Q8NC74	CT151_HUMAN	hypothetical protein LOC140893	401											0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;6.43e-06)			TGCCCTGGTCCCCTCATTCTC	0.711													11	12					0	0	1	0	0
YTHDF1	54915	broad.mit.edu	37	20	61834435	61834435	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:61834435G>A	uc002yeh.2	-	4	1151	c.857C>T	c.(856-858)CCC>CTC	p.P286L	YTHDF1_uc011aaq.1_Missense_Mutation_p.P236L	NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	286	Gln/Pro-rich.									ovary(2)	2						TGCCTGCTGGGGGACTGGGGC	0.652													44	48					0	0	1	0	0
PRIC285	85441	broad.mit.edu	37	20	62190680	62190680	+	Silent	SNP	G	A	A	rs141769251		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:62190680G>A	uc002yfm.2	-	20	8761	c.7869C>T	c.(7867-7869)CTC>CTT	p.L2623L	PRIC285_uc002yfl.1_Silent_p.L2054L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	2623					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			AGAAGTCCAGGAGGCTACGCC	0.632													9	15					0	0	1	0	0
PRIC285	85441	broad.mit.edu	37	20	62197147	62197147	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:62197147G>A	uc002yfm.2	-	9	3920	c.3028C>T	c.(3028-3030)CGT>TGT	p.R1010C	PRIC285_uc002yfl.1_Missense_Mutation_p.R441C	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1010	Ala-rich.				cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GTGATGTCACGGGATGCTGGG	0.682													4	12					0	0	1	0	0
MIR941-1	100126329	broad.mit.edu	37	20	62550813	62550813	+	RNA	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr20:62550813G>T	hsa-mir-941-1|MI0005763	+			c.20G>T			DNAJC5_uc002yhf.2_Intron|DNAJC5_uc002yhg.1_Intron|DNAJC5_uc002yhh.2_RNA|MIR941-2_hsa-mir-941-2|MI0005764_5'Flank|MIR941-3_hsa-mir-941-3|MI0005765_5'Flank																	0						GTGGACATGTGCCCAGGGCCC	0.711													20	28					5.26018e-13	5.31186e-13	1	1	0
TPTE	7179	broad.mit.edu	37	21	10916446	10916446	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:10916446C>T	uc002yip.1	-	20	1568	c.1200G>A	c.(1198-1200)GTG>GTA	p.V400V	TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Silent_p.V382V|TPTE_uc002yir.1_Silent_p.V362V|TPTE_uc010gkv.1_Silent_p.V262V	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	400	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGAGATGTTTCACTTGTGCAA	0.328													13	57					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10920116	10920116	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:10920116C>T	uc002yip.1	-	19	1506	c.1138G>A	c.(1138-1140)GAA>AAA	p.E380K	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.E362K|TPTE_uc002yir.1_Missense_Mutation_p.E342K|TPTE_uc010gkv.1_Missense_Mutation_p.E242K	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	380	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGAAATTTTTCGCTGTGGGTT	0.393													26	66					0	0	1	0	0
HSPA13	6782	broad.mit.edu	37	21	15746247	15746247	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:15746247G>A	uc002yjt.2	-	5	1176	c.1107C>T	c.(1105-1107)CTC>CTT	p.L369L	HSPA13_uc011abx.1_Silent_p.L161L	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	369						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						GGGTATCAAAGAGTTTCCGTG	0.418													44	63					0	0	1	0	0
MIR99A	407055	broad.mit.edu	37	21	17911434	17911434	+	RNA	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:17911434G>A	hsa-mir-99a|MI0000101	+			c.26G>A			C21orf34_uc002ykb.2_Intron|C21orf34_uc010glc.2_Intron|C21orf34_uc002ykc.2_Intron|uc002ykd.1_RNA|uc002yke.2_5'Flank|MIRLET7C_hsa-let-7c|MI0000064_5'Flank																	0						CCGTAGATCCGATCTTGTGGT	0.413													20	23					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37597932	37597932	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:37597932C>T	uc002yvg.2	+	12	1519	c.1440C>T	c.(1438-1440)GCC>GCT	p.A480A	DOPEY2_uc011aeb.1_Silent_p.A480A	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	480					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						AGCTCTGCGCCCTCCTGGTCT	0.522													16	19					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37617564	37617564	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:37617564C>T	uc002yvg.2	+	19	3365	c.3286C>T	c.(3286-3288)CCA>TCA	p.P1096S	DOPEY2_uc011aeb.1_Missense_Mutation_p.P1045S|DOPEY2_uc002yvh.2_5'UTR	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1096					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CGTGGAGCTTCCAGACAGGAC	0.637													27	21					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38568323	38568323	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:38568323C>T	uc002yvz.2	+	42	5670	c.5565C>T	c.(5563-5565)TTC>TTT	p.F1855F	TTC3_uc002ywa.2_Silent_p.F1855F|TTC3_uc002ywb.2_Silent_p.F1855F|TTC3_uc010gnf.2_Silent_p.F1620F|TTC3_uc002ywc.2_Silent_p.F1545F	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1855					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				CAGTGGTATTCCCATGTTACA	0.433													16	21					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	39086559	39086559	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:39086559C>T	uc011aej.1	-	3	954	c.901G>A	c.(901-903)GAA>AAA	p.E301K	KCNJ6_uc002ywo.2_Missense_Mutation_p.E301K	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	301	Cytoplasmic (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	ATTTCCAGTTCCTCTTTGGGC	0.478													40	57					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41539173	41539173	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:41539173G>A	uc002yyq.1	-	16	3442	c.2990C>T	c.(2989-2991)TCA>TTA	p.S997L	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	997	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCTCTGAGATGATATAGGCTC	0.517													27	30					0	0	1	0	0
SIK1	150094	broad.mit.edu	37	21	44837464	44837464	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:44837464C>T	uc002zdf.2	-	13	2062	c.1935G>A	c.(1933-1935)CGG>CGA	p.R645R		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	645					anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						TCCAGCCCTCCCGGCTGCCGG	0.751													8	7					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45535698	45535698	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:45535698G>A	uc002zeb.2	+	7	823	c.733G>A	c.(733-735)GAG>AAG	p.E245K		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	245	Poly-Glu.					cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		ggaagaggaggaggaggagga	0.527													7	18					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47847571	47847572	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:47847571_47847572CC>TT	uc002zji.3	+	34	7463_7464	c.7356_7357CC>TT	c.(7354-7359)GACCTT>GATTTT	p.L2453F	PCNT_uc002zjj.2_Missense_Mutation_p.L2335F	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2453					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GGAGAGGGGACCTTCTGCAGGT	0.545													30	40					0	0	1	0	0
PRMT2	3275	broad.mit.edu	37	21	48068504	48068504	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr21:48068504C>T	uc002zjx.2	+	6	776	c.462C>T	c.(460-462)TTC>TTT	p.F154F	PRMT2_uc002zjw.2_Silent_p.F154F|PRMT2_uc002zjy.2_Silent_p.F154F|PRMT2_uc010gqm.2_Silent_p.F154F|PRMT2_uc011aga.1_Silent_p.F154F|PRMT2_uc011agb.1_Silent_p.F154F|PRMT2_uc011agc.1_Silent_p.F154F|PRMT2_uc002zjz.1_Silent_p.F40F	NM_206962	NP_996845	P55345	ANM2_HUMAN	HMT1 hnRNP methyltransferase-like 1	154	Interaction with RB1 (By similarity).|Interaction with ESR1.				developmental cell growth|induction of apoptosis|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of androgen receptor signaling pathway	cytosol|nucleus	androgen receptor binding|estrogen receptor binding|histone-arginine N-methyltransferase activity|peroxisome proliferator activated receptor binding|progesterone receptor binding|protein homodimerization activity|retinoic acid receptor binding|signal transducer activity|thyroid hormone receptor binding|transcription coactivator activity			ovary(1)	1	Breast(49;0.247)	Lung NSC(3;0.245)		Epithelial(3;1.03e-07)|OV - Ovarian serous cystadenocarcinoma(3;4.68e-07)|all cancers(3;7.48e-07)|Colorectal(79;0.167)|Lung(125;0.203)|LUSC - Lung squamous cell carcinoma(216;0.23)|READ - Rectum adenocarcinoma(84;0.248)		TCAGTCTCTTCTGTGCACACT	0.562													37	51					0	0	1	0	0
DGCR2	9993	broad.mit.edu	37	22	19036064	19036064	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:19036064G>A	uc002zoq.1	-	7	1143	c.895C>T	c.(895-897)CAT>TAT	p.H299Y	DGCR2_uc002zor.1_Missense_Mutation_p.H75Y|DGCR2_uc011agr.1_Missense_Mutation_p.H255Y|DGCR11_uc002zos.2_5'Flank	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	299	Extracellular (Potential).|VWFC.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					TCCCCTCCATGGCAGGTGCAG	0.567													137	197					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19384447	19384447	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:19384447G>A	uc002zpf.1	-	7	737	c.517C>T	c.(517-519)CAT>TAT	p.H173Y	HIRA_uc011agx.1_Missense_Mutation_p.H39Y|HIRA_uc010grn.1_Missense_Mutation_p.H173Y|HIRA_uc010gro.1_Missense_Mutation_p.H129Y|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	173	WD 4.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					AAGCCAGAATGACCTCTCAGA	0.488													35	29					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19961759	19961759	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:19961759A>G	uc002zqz.2	-	12	2235	c.1964T>C	c.(1963-1965)TTT>TCT	p.F655S	ARVCF_uc002zqy.2_Missense_Mutation_p.F171S	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	655	ARM 7.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					CAGCAGCTCAAAGCCTAGGTG	0.642													3	9					0	0	1	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458247	20458247	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:20458247G>A	uc002zsd.3	-	1	3540	c.3055C>T	c.(3055-3057)CGC>TGC	p.R1019C		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			TGGGGGTGGCGGTGGCTGCTG	0.612													4	9					0	0	1	0	0
GNAZ	2781	broad.mit.edu	37	22	23438161	23438161	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:23438161C>T	uc002zwu.1	+	2	816	c.279C>T	c.(277-279)ATC>ATT	p.I93I	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	93						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		CCCTCAGGATCGACTTCCACA	0.642													56	96					0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24226883	24226883	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:24226883C>T	uc002zyn.3	+	12	1437	c.1338C>T	c.(1336-1338)GTC>GTT	p.V446V	SLC2A11_uc002zym.3_Silent_p.V453V|SLC2A11_uc002zyo.3_RNA|SLC2A11_uc011ajc.1_Missense_Mutation_p.S453F|SLC2A11_uc002zyp.3_Silent_p.V449V	NM_001024938	NP_001020109	Q9BYW1	GTR11_HUMAN	glucose transporter protein 10 isoform c	446	Helical; Name=12; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity			ovary(1)	1						GTGTCTGTGTCTGTGGGGCCA	0.527													63	83					0	0	1	0	0
CRYBB2	1415	broad.mit.edu	37	22	25625517	25625517	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:25625517G>A	uc003abp.1	+	5	469	c.421G>A	c.(421-423)GTG>ATG	p.V141M		NM_000496	NP_000487	P43320	CRBB2_HUMAN	crystallin, beta B2	141	Beta/gamma crystallin 'Greek key' 3.				response to stimulus|visual perception		structural constituent of eye lens				0						CCAGGAGAAGGTGTCATCTGT	0.448													12	28					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26399266	26399266	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:26399266G>A	uc003abz.1	+	41	6573	c.6323G>A	c.(6322-6324)CGA>CAA	p.R2108Q	MYO18B_uc003aca.1_Missense_Mutation_p.R1989Q|MYO18B_uc010guy.1_Missense_Mutation_p.R1990Q|MYO18B_uc010guz.1_Missense_Mutation_p.R1988Q|MYO18B_uc011aka.1_Missense_Mutation_p.R1262Q|MYO18B_uc011akb.1_Missense_Mutation_p.R1621Q|MYO18B_uc010gva.1_Intron	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2108						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AGCAGCGGCCGAAAAGAGATG	0.512													7	9					0	0	1	0	0
HORMAD2	150280	broad.mit.edu	37	22	30517760	30517760	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:30517760C>T	uc003agy.2	+	9	615	c.550C>T	c.(550-552)CTC>TTC	p.L184F		NM_152510	NP_689723	Q8N7B1	HORM2_HUMAN	HORMA domain containing 2	184	HORMA.				meiosis|mitosis	chromosome|nucleus					0			Epithelial(10;0.125)			TACTATGAAACTCCACTACTA	0.363													6	5					0	0	1	0	0
C22orf30	253143	broad.mit.edu	37	22	32108232	32108232	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:32108232A>C	uc003alp.3	-	4	5786	c.5593T>G	c.(5593-5595)TCT>GCT	p.S1865A	C22orf30_uc003alo.1_Missense_Mutation_p.S1664A|C22orf30_uc010gwj.1_Missense_Mutation_p.S1664A	NM_173566	NP_775837	Q5THK1	PR14L_HUMAN	hypothetical protein LOC253143	1865											0						GAGGCTGGAGACCGTAACCCT	0.527													40	67					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32445929	32445929	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:32445929G>A	uc003amc.2	+	2	368	c.136_splice	c.e2-1	p.A46_splice		NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose						carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						TTCCTCCTCAGGCTATGTTTT	0.473													75	127					0	0	1	0	0
BPIL2	254240	broad.mit.edu	37	22	32828468	32828468	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:32828468G>A	uc003amn.2	-	10	1041	c.1041C>T	c.(1039-1041)CCC>CCT	p.P347P	BPIL2_uc010gwo.2_Intron|BPIL2_uc011amb.1_Silent_p.P71P	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	347						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						GATTGATTATGGGAGGCTCTG	0.488													39	51					0	0	1	0	0
BPIL2	254240	broad.mit.edu	37	22	32831816	32831816	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:32831816G>A	uc003amn.2	-	8	799	c.799C>T	c.(799-801)CCT>TCT	p.P267S	BPIL2_uc010gwo.2_Missense_Mutation_p.P81S|BPIL2_uc011amb.1_5'UTR	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	267						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						AGCACAAAAGGAACTGGTGAG	0.473													30	43					0	0	1	0	0
LARGE	9215	broad.mit.edu	37	22	33670592	33670592	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:33670592G>A	uc003and.3	-	16	2671	c.2092C>T	c.(2092-2094)CTG>TTG	p.L698L	LARGE_uc011amd.1_Silent_p.L497L|LARGE_uc003ane.3_Silent_p.L698L|LARGE_uc010gwp.2_Silent_p.L646L|LARGE_uc011ame.1_Silent_p.L630L|LARGE_uc011amf.1_Silent_p.L649L	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	698	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				GCGTTGGGCAGCACAATGAAC	0.512											OREG0026497	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	29					0	0	1	0	0
ISX	91464	broad.mit.edu	37	22	35481508	35481508	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:35481508C>T	uc003anj.2	+	4	1511	c.560C>T	c.(559-561)TCG>TTG	p.S187L	ISX_uc011amg.1_Missense_Mutation_p.S175L	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	187						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S187S(1)		ovary(3)|skin(2)	5						TGTTGTCCATCGGCTCAAGAT	0.612													53	67					0	0	1	0	0
MFNG	4242	broad.mit.edu	37	22	37882171	37882171	+	Silent	SNP	G	A	A	rs77701703	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:37882171G>A	uc003ass.1	-	1	215	c.45C>T	c.(43-45)ACC>ACT	p.T15T	MFNG_uc011ani.1_5'UTR|MFNG_uc011anj.1_Silent_p.T15T|CARD10_uc003ast.1_Intron	NM_002405	NP_002396	O00587	MFNG_HUMAN	O-fucosylpeptide	15	Helical; Signal-anchor for type II membrane protein; (Potential).				pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			lung(1)	1	Melanoma(58;0.0574)					TGCACAGGAGGGTGAGGAGGG	0.692													11	19					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38035853	38035854	+	Splice_Site	DNP	GG	AA	AA			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:38035853_38035854GG>AA	uc003ati.2	+	1	170	c.59_splice	c.e1+1	p.R20_splice	SH3BP1_uc003atg.1_Splice_Site|SH3BP1_uc011anl.1_Splice_Site_p.R20_splice|SH3BP1_uc003ath.1_Splice_Site_p.R20_splice|SH3BP1_uc003atj.1_Splice_Site|SH3BP1_uc003atk.1_5'Flank	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1						signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					AGCTTGGGACGGTGAGTGTCAC	0.698													4	5					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121702	38121702	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:38121702C>T	uc003atr.2	+	7	3410	c.3139C>T	c.(3139-3141)CCT>TCT	p.P1047S	TRIOBP_uc003atu.2_Missense_Mutation_p.P875S|TRIOBP_uc003atq.1_Missense_Mutation_p.P1047S|TRIOBP_uc003ats.1_Missense_Mutation_p.P875S	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	1047					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GCCCCGCGCCCCTGAGAGTGA	0.667													34	61					0	0	1	0	0
SLC16A8	23539	broad.mit.edu	37	22	38478710	38478710	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:38478710C>T	uc003auu.2	-	2	301	c.171G>A	c.(169-171)ACG>ACA	p.T57T		NM_013356	NP_037488	O95907	MOT3_HUMAN	solute carrier family 16, member 8	57	Extracellular (Potential).				blood coagulation|leukocyte migration|pyruvate metabolic process	integral to plasma membrane|membrane fraction	lactate transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity				0	Melanoma(58;0.045)				Pyruvic acid(DB00119)	ACACCCAGGCCGTGTCGCTGT	0.682													5	4					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38516831	38516831	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:38516831G>A	uc003auy.1	-	12	1813	c.1677C>T	c.(1675-1677)CCC>CCT	p.P559P	PLA2G6_uc003auz.1_Silent_p.P505P|PLA2G6_uc003ava.1_Silent_p.P559P|PLA2G6_uc003avb.2_Silent_p.P505P|PLA2G6_uc010gxk.1_RNA	NM_003560	NP_003551	O60733	PA2G6_HUMAN	phospholipase A2, group VI isoform a	559					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				ovary(1)	1	Melanoma(58;0.045)				Quinacrine(DB01103)	ACTCCTCCAGGGGCCCCGACT	0.617													41	59					0	0	1	0	0
TMEM184B	25829	broad.mit.edu	37	22	38620935	38620935	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:38620935G>A	uc003avf.1	-	8	1063	c.839C>T	c.(838-840)TCG>TTG	p.S280L	TMEM184B_uc003avg.1_Missense_Mutation_p.S280L|TMEM184B_uc003avh.1_Missense_Mutation_p.S214L	NM_012264	NP_036396	Q9Y519	T184B_HUMAN	transmembrane protein 184B	280						integral to membrane					0	Melanoma(58;0.045)					CACGCGGGCCGAGTGGATTTT	0.637													6	7					0	0	1	0	0
TEF	7008	broad.mit.edu	37	22	41783516	41783516	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:41783516G>A	uc003azy.2	+	2	405	c.319G>A	c.(319-321)GAG>AAG	p.E107K	TEF_uc003azx.2_Missense_Mutation_p.E77K|TEF_uc011apa.1_Missense_Mutation_p.E112K	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	107					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTTCCTGCTGGAGAATGGCAT	0.582													45	43					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42174719	42174719	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:42174719G>A	uc003baz.1	+	22	2743	c.2718G>A	c.(2716-2718)GGG>GGA	p.G906G	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Silent_p.G292G|MEI1_uc003bbc.1_Silent_p.G274G|MEI1_uc010gym.1_Intron|MEI1_uc003bbd.1_Silent_p.G149G|MEI1_uc010gyn.1_RNA|MEI1_uc003bbe.1_RNA|MEI1_uc011apf.1_5'Flank|MEI1_uc010gyo.1_5'Flank|MEI1_uc003bbf.2_5'Flank|MEI1_uc003bbg.2_5'Flank	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	906							binding			central_nervous_system(1)|skin(1)	2						CAGCCTCGGGGAACCTACCAT	0.547													4	6					0	0	1	0	0
PARVB	29780	broad.mit.edu	37	22	44489833	44489833	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:44489833G>C	uc003ben.2	+	2	190	c.138G>C	c.(136-138)AAG>AAC	p.K46N	PARVB_uc003bem.2_Missense_Mutation_p.K79N|PARVB_uc010gzn.2_5'UTR|PARVB_uc003beo.2_Missense_Mutation_p.K9N	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	46					cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				AAGAAGGCAAGAATGCCATCA	0.562													25	45					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655701	46655701	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:46655701C>T	uc003bhh.2	-	1	3519	c.3519G>A	c.(3517-3519)CGG>CGA	p.R1173R		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1173	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TGATGTTTAACCGTAGATCCA	0.488													39	76					0	0	1	0	0
GTSE1	51512	broad.mit.edu	37	22	46712274	46712274	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:46712274C>T	uc011aqy.1	+	7	1609	c.1397C>T	c.(1396-1398)CCT>CTT	p.P466L	GTSE1_uc011aqz.1_Missense_Mutation_p.P313L|GTSE1_uc003bhl.1_Missense_Mutation_p.P91L|GTSE1_uc003bhm.1_Missense_Mutation_p.P91L	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	447					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		ATGCCTACTCCTACAAATCAA	0.318													50	84					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46795689	46795689	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:46795689G>A	uc003bhw.1	-	10	5337	c.5337C>T	c.(5335-5337)ATC>ATT	p.I1779I	CELSR1_uc011arc.1_Silent_p.I100I	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1779	Extracellular (Potential).|Laminin G-like 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCTTCAGCTCGATCAGCAGGT	0.592													23	25					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50552966	50552966	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr22:50552966T>C	uc003bjj.2	+	7	1124	c.1041T>C	c.(1039-1041)AAT>AAC	p.N347N	MOV10L1_uc003bjk.3_Silent_p.N347N|MOV10L1_uc011arp.1_Silent_p.N327N|MOV10L1_uc011arq.1_Silent_p.N108N|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	347					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CAGATGAAAATATTAATTCAT	0.393													10	27					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	430940	430940	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:430940G>A	uc003bou.2	+	19	2476	c.2205G>A	c.(2203-2205)TTG>TTA	p.L735L	CHL1_uc003bot.2_Silent_p.L751L|CHL1_uc003bow.1_Silent_p.L735L|CHL1_uc011asi.1_Silent_p.L751L	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	735	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		tttagcctttgaaatccatgg	0.264													12	9					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1444012	1444013	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:1444012_1444013GG>AA	uc003boz.2	+	22	3095_3096	c.2828_2829GG>AA	c.(2827-2829)CGG>CAA	p.R943Q	CNTN6_uc011asj.1_Missense_Mutation_p.R871Q|CNTN6_uc003bpa.2_Missense_Mutation_p.R943Q	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	943	Fibronectin type-III 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ATTCTGTACCGGCAAAACAGAC	0.351													12	23					0	0	1	0	0
BRPF1	7862	broad.mit.edu	37	3	9786133	9786134	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:9786133_9786134CC>TT	uc003bse.2	+	9	3242_3243	c.2843_2844CC>TT	c.(2842-2844)CCC>CTT	p.P948L	BRPF1_uc003bsf.2_Missense_Mutation_p.P954L|BRPF1_uc003bsg.2_Missense_Mutation_p.P947L|BRPF1_uc011ati.1_Intron	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	948	Required for RUNX1 and RUNX2 transcriptional activation.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					GGTAGGAGCCCCCGGCCCAGTT	0.644													12	9					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17109458	17109458	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:17109458C>T	uc011awc.1	+	8	3186	c.3081C>T	c.(3079-3081)TTC>TTT	p.F1027F	PLCL2_uc011awd.1_Silent_p.F909F	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	1035					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						CCATGGAATTCCATGAACACT	0.363													26	34					0	0	1	0	0
SGOL1	151648	broad.mit.edu	37	3	20215927	20215927	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:20215927C>T	uc003cbs.2	-	6	1283	c.1096G>A	c.(1096-1098)GTG>ATG	p.V366M	SGOL1_uc003cbr.2_Intron|SGOL1_uc010hfa.2_Intron|SGOL1_uc003cbt.2_Intron|SGOL1_uc003cbu.2_Missense_Mutation_p.V366M|SGOL1_uc003cbv.2_Intron|SGOL1_uc003cbw.2_Intron|SGOL1_uc003cbx.2_Intron|SGOL1_uc003cby.2_Intron|SGOL1_uc003cbz.2_Missense_Mutation_p.V366M|SGOL1_uc003cca.2_Missense_Mutation_p.V366M|SGOL1_uc003ccb.2_Intron|SGOL1_uc003ccc.2_Intron	NM_001012410	NP_001012410	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 isoform A2	366					attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0						CAGAGGCTCACTTCAGACTCG	0.413													28	45					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898195	36898195	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:36898195C>T	uc003cgj.2	-	3	1538	c.1236G>A	c.(1234-1236)AGG>AGA	p.R412R		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	962					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TGACATGCTCCCTGCCCTTCT	0.473													66	106					0	0	1	0	0
MYD88	4615	broad.mit.edu	37	3	38180251	38180252	+	Missense_Mutation	DNP	TC	CA	CA			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:38180251_38180252TC>CA	uc003chx.2	+	1	283_284	c.99_100TC>CA	c.(97-102)CTTCCC>CTCACC	p.P34T	ACAA1_uc003cht.2_5'Flank|ACAA1_uc003chu.2_5'Flank|ACAA1_uc010hgy.2_5'Flank|ACAA1_uc010hgz.2_5'Flank|ACAA1_uc003chv.2_5'Flank|MYD88_uc011ayh.1_Missense_Mutation_p.P34T|MYD88_uc011ayi.1_Missense_Mutation_p.P34T|MYD88_uc011ayj.1_Missense_Mutation_p.P34T|MYD88_uc011ayk.1_Missense_Mutation_p.P34T|MYD88_uc011ayl.1_Missense_Mutation_p.P34T	NM_002468	NP_002459	Q99836	MYD88_HUMAN	myeloid differentiation primary response gene	21					3'-UTR-mediated mRNA stabilization|anti-apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|regulation of inflammatory response|response to interleukin-1|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|intrinsic to membrane|plasma membrane	death receptor binding|TIR domain binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(93)|breast(1)	94				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CATCCTCCCTTCCCCTGGCTGC	0.703			Mis 		ABC-DLBCL								9	13					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38651405	38651405	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:38651405C>T	uc003cio.2	-	7	948	c.754G>A	c.(754-756)GAT>AAT	p.D252N	SCN5A_uc003cin.2_Missense_Mutation_p.D252N|SCN5A_uc003cil.3_Missense_Mutation_p.D252N|SCN5A_uc010hhi.2_Missense_Mutation_p.D252N|SCN5A_uc010hhk.2_Missense_Mutation_p.D252N|SCN5A_uc011ayr.1_Missense_Mutation_p.D252N|SCN5A_uc010hhl.1_Missense_Mutation_p.D75N	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	252					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACCATCACATCAGCCAGCTTC	0.597													24	34					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739587	38739587	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:38739587G>A	uc003ciq.2	-	27	5124	c.5124C>T	c.(5122-5124)ATC>ATT	p.I1708I		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1708	IV.|Helical; Name=S6 of repeat IV; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGAGGAAGGAGATGATGATGT	0.542													31	38					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38904762	38904762	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:38904762T>A	uc011ays.1	-	24	4179	c.3980A>T	c.(3979-3981)GAA>GTA	p.E1327V	SCN11A_uc003cis.1_5'UTR	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1327					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTCTGTTCTTCTGTCATAAA	0.328													14	26					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38908865	38908865	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:38908865G>A	uc011ays.1	-	23	4097	c.3898C>T	c.(3898-3900)CTG>TTG	p.L1300L		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1300	Helical; Name=S6 of repeat III; (By similarity).|III.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAGAGATTCAGAGTGAAGAAT	0.363													16	27					0	0	1	0	0
CSRNP1	64651	broad.mit.edu	37	3	39184611	39184611	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:39184611G>A	uc003cjg.2	-	5	1919	c.1705C>T	c.(1705-1707)CCC>TCC	p.P569S	CSRNP1_uc003cjh.2_Missense_Mutation_p.P569S	NM_033027	NP_149016	Q96S65	CSRN1_HUMAN	AXIN1 up-regulated 1	569					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(4)|skin(1)	5						TCAATAAAGGGATCTAGGGCT	0.592													34	49					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39229363	39229364	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:39229363_39229364CC>TT	uc003cjk.1	-	2	1794_1795	c.1573_1574GG>AA	c.(1573-1575)GGC>AAC	p.G525N	XIRP1_uc003cji.2_Missense_Mutation_p.G525N|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	525							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGGGCTTCGGCCGAGCTGGTCT	0.624													23	28					0	0	1	0	0
ZNF619	285267	broad.mit.edu	37	3	40529675	40529675	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:40529675C>T	uc011azb.1	+	6	2072	c.1794C>T	c.(1792-1794)CTC>CTT	p.L598L	ZNF619_uc010hhz.2_Silent_p.L549L|ZNF619_uc003ckj.2_Silent_p.L542L|ZNF619_uc011azc.1_Silent_p.L558L|ZNF619_uc011azd.1_Silent_p.L514L|ZNF619_uc011aza.1_Silent_p.L500L	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	598					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TTCAGGATCTCGCTTTTCCTG	0.498													38	55					0	0	1	0	0
ABHD5	51099	broad.mit.edu	37	3	43756547	43756547	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:43756547C>T	uc003cmx.2	+	5	880	c.770C>T	c.(769-771)CCA>CTA	p.P257L		NM_016006	NP_057090	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	257					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			ovary(1)	1		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		GTGCAGACTCCAAGGTGAGGG	0.289													20	12					0	0	1	0	0
ZNF197	10168	broad.mit.edu	37	3	44672663	44672663	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:44672663C>G	uc003cnm.2	+	3	706	c.500C>G	c.(499-501)CCG>CGG	p.P167R	ZNF197_uc003cnn.2_Missense_Mutation_p.P167R|ZNF197_uc003cno.2_RNA|ZNF197_uc003cnp.2_Missense_Mutation_p.P167R	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	167					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		GAAATTTGCCCGCATCCTCCT	0.527													34	42					0	0	1	0	0
CCR1	1230	broad.mit.edu	37	3	46244764	46244764	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:46244764C>T	uc003cph.1	-	2	1112	c.1041G>A	c.(1039-1041)GGG>GGA	p.G347G	CCR3_uc003cpg.1_Intron	NM_001295	NP_001286	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	347	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			skin(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GTTCATGCTCCCCTGTGGAGG	0.592													28	23					0	0	1	0	0
CCR2	729230	broad.mit.edu	37	3	46401237	46401237	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:46401237G>A	uc003cpn.3	+	3	1496	c.1011G>A	c.(1009-1011)GTG>GTA	p.V337V		NM_001123041	NP_001116513	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2 isoform A	337	Cytoplasmic (Potential).				astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			lung(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		GTCCAGGAGTGAGACCAGGAA	0.507													38	38					0	0	1	0	0
LTF	4057	broad.mit.edu	37	3	46488859	46488859	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:46488859C>T	uc003cpq.2	-	10	1281	c.1243G>A	c.(1243-1245)GGA>AGA	p.G415R	LTF_uc003fzr.2_Missense_Mutation_p.G371R|LTF_uc010hjh.2_Missense_Mutation_p.G413R|LTF_uc003cpr.2_Missense_Mutation_p.G402R	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	415	Transferrin-like 2.			G -> E (in Ref. 4; AAA59511).	cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	ACATATCCTCCATCCAAACTC	0.502													54	106					0	0	1	0	0
CCDC12	151903	broad.mit.edu	37	3	46964839	46964839	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:46964839G>A	uc011baq.1	-	4	612	c.603C>T	c.(601-603)CTC>CTT	p.L201L	CCDC12_uc003cqo.2_Silent_p.L120L	NM_144716	NP_653317	Q8WUD4	CCD12_HUMAN	coiled-coil domain containing 12	107											0		Prostate(884;0.0143)|Ovarian(412;0.0448)|Acute lymphoblastic leukemia(5;0.143)		OV - Ovarian serous cystadenocarcinoma(275;2.2e-56)|BRCA - Breast invasive adenocarcinoma(193;0.00136)|KIRC - Kidney renal clear cell carcinoma(197;0.00703)|Kidney(197;0.00809)		TCCGAGGAGCGAGGTTGGCCA	0.532											OREG0015545	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	12					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48627094	48627094	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:48627094G>A	uc003ctz.2	-	16	2109	c.2108C>T	c.(2107-2109)ACC>ATC	p.T703I		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	703	Nonhelical region (NC1).|Fibronectin type-III 6.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCAGGTAATGGTGACAGATGA	0.632													33	55					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49935521	49935521	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:49935521G>A	uc003cxy.3	-	5	2107	c.1843C>T	c.(1843-1845)CCC>TCC	p.P615S	MST1R_uc011bdd.1_Missense_Mutation_p.P615S|MST1R_uc011bde.1_Missense_Mutation_p.P615S|MST1R_uc011bdf.1_Missense_Mutation_p.P509S|MST1R_uc011bdc.1_5'Flank	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	615	IPT/TIG 1.|Extracellular (Potential).				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		GGCCGGCAGGGACTTTGGCCC	0.592													27	35					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52404140	52404140	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:52404140C>T	uc011bef.1	+	39	6414	c.6153C>T	c.(6151-6153)TTC>TTT	p.F2051F		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2051	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCATCTCCTTCGTTCGGTCCT	0.587													14	20					0	0	1	0	0
TNNC1	7134	broad.mit.edu	37	3	52486251	52486251	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:52486251C>T	uc003deb.2	-	3	99	c.73G>A	c.(73-75)GAC>AAC	p.D25N	NISCH_uc011beg.1_5'Flank	NM_003280	NP_003271	P63316	TNNC1_HUMAN	troponin C, slow	25	EF-hand 1.				cardiac muscle contraction|muscle filament sliding|regulation of ATPase activity|regulation of muscle filament sliding speed|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin filament binding|calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|troponin I binding|troponin T binding				0				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00175)|KIRC - Kidney renal clear cell carcinoma(197;0.00198)|OV - Ovarian serous cystadenocarcinoma(275;0.0525)	Bepridil(DB01244)|Dihydroxyaluminium(DB01375)|Levosimendan(DB00922)	ACGAAGATGTCGAAGGCTGCC	0.637													32	48					0	0	1	0	0
RFT1	91869	broad.mit.edu	37	3	53155763	53155763	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:53155763G>A	uc003dgj.2	-	5	564	c.510C>T	c.(508-510)CTC>CTT	p.L170L	RFT1_uc003dgk.2_Silent_p.L131L	NM_052859	NP_443091	Q96AA3	RFT1_HUMAN	RFT1 homolog	170	Helical; (Potential).				carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		ACCACAGCACGAGAAAAGCTG	0.413													9	10					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54958793	54958793	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:54958793C>T	uc003dhl.2	-	2	591	c.457G>A	c.(457-459)GTT>ATT	p.V153I	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	153	Extracellular (Potential).|LRR 5.					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		TTTTGTTGAACCGCAAGTATA	0.488													32	44					0	0	1	0	0
FRMD4B	23150	broad.mit.edu	37	3	69360499	69360499	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:69360499G>A	uc003dnv.2	-	3	528	c.238C>T	c.(238-240)CTA>TTA	p.L80L	FRMD4B_uc003dnw.2_Intron|FRMD4B_uc003dnx.1_Silent_p.L26L|FRMD4B_uc003dny.2_Silent_p.L80L	NM_015123	NP_055938	Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	80	FERM.					cytoplasm|cytoskeleton	binding			ovary(3)|central_nervous_system(1)	4		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		TCTCTTGCTAGAAGTTTGGGC	0.378													8	8					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	86996198	86996198	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:86996198C>T	uc003dqn.2	-	4	1321	c.957G>A	c.(955-957)AAG>AAA	p.K319K		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	319					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		ATTCCTTACTCTTGTCTTGAT	0.383													18	36					0	0	1	0	0
HTR1F	3355	broad.mit.edu	37	3	88040297	88040297	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:88040297G>A	uc003dqr.2	+	2	556	c.398G>A	c.(397-399)AGG>AAG	p.R133K		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	133	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	GAGTATGCCAGGAAAAGGACT	0.438													13	27					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89259262	89259262	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:89259262C>T	uc003dqy.2	+	3	631	c.406C>T	c.(406-408)CGA>TGA	p.R136*	EPHA3_uc003dqx.1_Nonsense_Mutation_p.R136*|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	136	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GGTGAAATTTCGAGAGCATCA	0.418										TSP Lung(6;0.00050)			42	57					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96706525	96706525	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:96706525C>T	uc010how.1	+	3	845	c.802C>T	c.(802-804)CGT>TGT	p.R268C	EPHA6_uc003drp.1_Missense_Mutation_p.R268C	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	173	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.R174C(1)		stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CACTGAAATTCGTGAGGTGGG	0.443													96	137					0	0	1	0	0
OR5K2	402135	broad.mit.edu	37	3	98216779	98216779	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:98216779C>T	uc011bgx.1	+	1	255	c.255C>T	c.(253-255)TTC>TTT	p.F85F		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TAGAGAACTTCTTTTCTGAGG	0.443													66	105					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108719493	108719493	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:108719493C>T	uc003dxl.2	-	21	2185	c.2098G>A	c.(2098-2100)GAA>AAA	p.E700K	MORC1_uc011bhn.1_Missense_Mutation_p.E679K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	700					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CTTTTCATTTCCCAAGAAGCG	0.373													35	35					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108751625	108751625	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:108751625C>T	uc003dxl.2	-	16	1594	c.1507G>A	c.(1507-1509)GAA>AAA	p.E503K	MORC1_uc011bhn.1_Missense_Mutation_p.E503K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	503	CW-type.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						AATTCTTTTTCCTGATAATTA	0.289													12	24					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113346517	113346517	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:113346517C>T	uc003eak.2	+	25	3097	c.2446C>T	c.(2446-2448)CTT>TTT	p.L816F	SIDT1_uc011big.1_Missense_Mutation_p.L569F|SIDT1_uc011bii.1_Missense_Mutation_p.L269F	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	816	Cytoplasmic (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						GGATGATGACCTTGATGTGGT	0.443													37	53					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113374479	113374479	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:113374479G>A	uc003eam.2	-	7	6461	c.6050C>T	c.(6049-6051)TCT>TTT	p.S2017F	KIAA2018_uc003eal.2_Missense_Mutation_p.S1961F	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	2017					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GCCACCAGTAGAGAGAGGAAG	0.458													11	28					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118866303	118866304	+	Missense_Mutation	DNP	CC	TT	TT	rs113445078		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:118866303_118866304CC>TT	uc003ecb.1	+	1	1307_1308	c.1267_1268CC>TT	c.(1267-1269)CCA>TTA	p.P423L	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Missense_Mutation_p.P423L	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	423										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		ACCCTACAACCCAGTTGATGCC	0.446													17	33					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	121100379	121100379	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:121100379G>A	uc003eec.3	+	23	2799	c.2659G>A	c.(2659-2661)GGT>AGT	p.G887S	STXBP5L_uc011bji.1_Missense_Mutation_p.G863S	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	887	WD 11.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		ATTGCCAAGTGGTAAGAGTTT	0.343													39	41					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121712501	121712501	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:121712501C>T	uc003ees.2	-	7	1201	c.1095G>A	c.(1093-1095)AGG>AGA	p.R365R	ILDR1_uc003eeq.2_Silent_p.R333R|ILDR1_uc003eer.2_Silent_p.R321R|ILDR1_uc010hrg.2_Silent_p.R276R	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	365	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		TTCTCCCCTCCCTCAGATCCC	0.597													19	34					0	0	1	0	0
PARP15	165631	broad.mit.edu	37	3	122354921	122354921	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:122354921G>A	uc003efm.2	+	12	2077	c.2011G>A	c.(2011-2013)GAA>AAA	p.E671K	PARP15_uc003efn.2_Missense_Mutation_p.E476K|PARP15_uc003efo.1_Missense_Mutation_p.E418K|PARP15_uc003efp.1_Missense_Mutation_p.E437K|PARP15_uc011bjt.1_Missense_Mutation_p.E368K	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	649	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		GGCTTACCCAGAATATCTCAT	0.353													9	21					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	124998089	124998089	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:124998089G>A	uc003ehx.3	-	6	948	c.462C>T	c.(460-462)ATC>ATT	p.I154I	SLC12A8_uc003ehw.3_5'UTR|ZNF148_uc003ehz.3_Silent_p.I154I|ZNF148_uc010hsa.2_Silent_p.I154I|ZNF148_uc003eia.3_Silent_p.I154I|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	154					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						TTATTGTAAGGATCTAGTTCA	0.299													21	30					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126219672	126219672	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:126219672C>T	uc003eiz.1	-	11	1043	c.1011G>A	c.(1009-1011)GTG>GTA	p.V337V	UROC1_uc010hsi.1_Silent_p.V397V	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	337					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		ACCCCAGGTCCACCAAGCACT	0.632													18	26					0	0	1	0	0
KIAA1257	57501	broad.mit.edu	37	3	128706597	128706597	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:128706597C>T	uc003elj.3	-	4	725	c.529G>A	c.(529-531)GAA>AAA	p.E177K	KIAA1257_uc003elg.1_Missense_Mutation_p.E177K|KIAA1257_uc003eli.3_Missense_Mutation_p.E65K	NM_020741	NP_065792	Q9ULG3	K1257_HUMAN	hypothetical protein LOC57501	177											0						TTTAATAATTCCTTTGTCACA	0.398													13	10					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129221700	129221700	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:129221700A>T	uc003emm.2	+	20	2728	c.2522A>T	c.(2521-2523)CAC>CTC	p.H841L	IFT122_uc003eml.2_Missense_Mutation_p.H892L|IFT122_uc003emn.2_Missense_Mutation_p.H782L|IFT122_uc003emo.2_Missense_Mutation_p.H730L|IFT122_uc003emp.2_Missense_Mutation_p.H691L|IFT122_uc010htc.2_Missense_Mutation_p.H833L|IFT122_uc011bky.1_Missense_Mutation_p.H632L|IFT122_uc003emq.2_Missense_Mutation_p.H681L|IFT122_uc003emr.2_Missense_Mutation_p.H593L|IFT122_uc011bla.1_Missense_Mutation_p.H614L|IFT122_uc010hte.2_Missense_Mutation_p.H167L|IFT122_uc003ems.2_Missense_Mutation_p.H222L|IFT122_uc011bkx.1_Missense_Mutation_p.H681L|IFT122_uc010htd.1_Missense_Mutation_p.H320L	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	841					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						GTGCAGCTGCACGTGGAGACC	0.647													19	28					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131306348	131306348	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:131306348C>T	uc003eok.2	-	8	1195	c.760G>A	c.(760-762)GGA>AGA	p.G254R	CPNE4_uc011blq.1_Missense_Mutation_p.G272R|CPNE4_uc003eol.2_Missense_Mutation_p.G272R|CPNE4_uc003eom.2_Missense_Mutation_p.G254R	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	254										upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCCATTGCTCCTCTCATCTCC	0.448													20	30					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132207199	132207199	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:132207199A>G	uc003eor.2	+	30	3390	c.3325A>G	c.(3325-3327)ATC>GTC	p.I1109V		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1109							heat shock protein binding			ovary(1)|breast(1)	2						GTTATACCATATCATGCAAGA	0.373													16	25					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133667501	133667501	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:133667501G>A	uc003eqa.3	-	8	1258	c.984C>T	c.(982-984)TTC>TTT	p.F328F	SLCO2A1_uc003eqb.3_Silent_p.F252F|SLCO2A1_uc011blv.1_Silent_p.F147F	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	328	Helical; Name=7; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						CCACCAGGACGAAGAGTGAGT	0.572													54	53					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	139894863	139894863	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:139894863T>G	uc003etn.2	+	2	370	c.180T>G	c.(178-180)ATT>ATG	p.I60M	CLSTN2_uc003etm.2_Missense_Mutation_p.I60M	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	60	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						ACACAGTCATTTTGGACCCAC	0.453										HNSCC(16;0.037)			16	24					0	0	1	0	0
PLSCR4	57088	broad.mit.edu	37	3	145914451	145914451	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:145914451T>C	uc010huy.2	-	7	1083	c.754A>G	c.(754-756)ACC>GCC	p.T252A	PLSCR4_uc010huz.2_Missense_Mutation_p.T252A|PLSCR4_uc003evt.3_Missense_Mutation_p.T252A|PLSCR4_uc010hva.2_Missense_Mutation_p.T162A|PLSCR4_uc003evu.3_Missense_Mutation_p.T147A	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	252	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						CAGCCATAGGTTGAGCATGGC	0.408													24	33					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151165643	151165643	+	Missense_Mutation	SNP	C	T	T	rs79636265	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:151165643C>T	uc011bod.1	-	4	2126	c.2126G>A	c.(2125-2127)GGA>GAA	p.G709E		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	709					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGTGTGTTTTCCAACCTCAGC	0.488													20	26					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154139227	154139227	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:154139227C>T	uc003faa.2	-	3	1324	c.1224G>A	c.(1222-1224)GGG>GGA	p.G408G		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	408	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTTTATAAATCCCATAACTTT	0.313													21	23					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167023654	167023654	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:167023654G>A	uc003fep.2	-	17	1825	c.1502C>T	c.(1501-1503)TCC>TTC	p.S501F	ZBBX_uc011bpc.1_Missense_Mutation_p.S501F|ZBBX_uc003feq.2_Missense_Mutation_p.S472F	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	501						intracellular	zinc ion binding			ovary(2)	2						TCTTTCAAAGGAGGTGCTTTC	0.343													8	14					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167185017	167185017	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:167185017C>T	uc003fer.1	-	2	362	c.304G>A	c.(304-306)GAA>AAA	p.E102K	SERPINI2_uc003fes.1_Missense_Mutation_p.E112K|SERPINI2_uc003fet.1_Missense_Mutation_p.E102K	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	102					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						AATGTAAATTCTTGTTTTTTC	0.328													11	23					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	169099230	169099230	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:169099230G>A	uc011bpj.1	-	2	523	c.120C>T	c.(118-120)TCC>TCT	p.S40S	MECOM_uc003ffl.2_Silent_p.S12S|MECOM_uc011bpk.1_Intron|MECOM_uc010hwn.2_Silent_p.S40S|MECOM_uc011bpl.1_Silent_p.S40S	NM_004991	NP_004982	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform c	Error:Variant_position_missing_in_Q03112_after_alignment					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GAATATTGAGGGAGGGAGTGC	0.453													23	28					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169664092	169664092	+	RNA	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:169664092G>A	uc011bpp.1	-	2		c.3711C>T				NR_027622				Homo sapiens cDNA FLJ41016 fis, clone UTERU2018784.												0						AAGTCACACAGTAGAAGTCCT	0.502													15	24					0	0	1	0	0
PLD1	5337	broad.mit.edu	37	3	171455441	171455441	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:171455441G>A	uc003fhs.2	-	3	285	c.169C>T	c.(169-171)CCT>TCT	p.P57S	PLD1_uc003fht.2_Missense_Mutation_p.P57S	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	57					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GCAGAGAAAGGGATATACACT	0.328													14	17					0	0	1	0	0
NAALADL2	254827	broad.mit.edu	37	3	175473144	175473144	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:175473144T>A	uc003fit.2	+	13	2214	c.2127T>A	c.(2125-2127)AAT>AAA	p.N709K		NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	709	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		GGATGCTGAATGACATTCTCC	0.468													11	12					0	0	1	0	0
PSMD2	5708	broad.mit.edu	37	3	184020522	184020522	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:184020522C>T	uc003fnn.1	+	7	952	c.919C>T	c.(919-921)CTG>TTG	p.L307L	PSMD2_uc011brj.1_Silent_p.L148L|PSMD2_uc011brk.1_Silent_p.L177L	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	307					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	GTTCCTGGAGCTGAGTGAAGA	0.532													42	55					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184573563	184573563	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:184573563C>T	uc003fpb.1	+	13	1265	c.1094C>T	c.(1093-1095)CCC>CTC	p.P365L	VPS8_uc010hyd.1_Missense_Mutation_p.P365L	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	367							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TACGTGAATCCCATGCTTGCC	0.393													59	107					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186460032	186460032	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:186460032G>A	uc011bsa.1	+	10	2059	c.1847G>A	c.(1846-1848)GGA>GAA	p.G616E	KNG1_uc003fqr.2_Intron	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	616					blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	AAATGTCCTGGACGCCCCTGG	0.408													41	56					0	0	1	0	0
RPL39L	116832	broad.mit.edu	37	3	186839019	186839019	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:186839019G>A	uc003fre.1	-	3	425	c.70C>T	c.(70-72)CCC>TCC	p.P24S	RPL39L_uc003frf.1_RNA	NM_052969	NP_443201	Q96EH5	RL39L_HUMAN	ribosomal protein L39-like protein	24					spermatogenesis|translation	cytosolic large ribosomal subunit	structural constituent of ribosome				0	all_cancers(143;2.61e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.87e-18)	GBM - Glioblastoma multiforme(93;0.0745)		ATCCACTGGGGGATGGGACGA	0.448													44	44					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189681855	189681855	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:189681855G>A	uc011bsk.1	-	14	2314	c.1926C>T	c.(1924-1926)ATC>ATT	p.I642I	LEPREL1_uc003fsg.2_Silent_p.I461I	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	642	Fe2OG dioxygenase.				collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ATGAGAAGCTGATCATGCGCC	0.448													32	34					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193002735	193002735	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:193002735C>T	uc011bsq.1	-	27	3194	c.3194G>A	c.(3193-3195)GGA>GAA	p.G1065E		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	1065					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		AAATGGCTTTCCCTTAGAAAA	0.368													16	17					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505223	195505223	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr3:195505223G>A	uc011bto.1	-	4	12970	c.12510C>T	c.(12508-12510)GCC>GCT	p.A4170A	MUC4_uc003fva.2_5'UTR|MUC4_uc003fvb.2_5'UTR|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_5'UTR|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_5'UTR|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_5'UTR|MUC4_uc011bti.1_5'UTR|MUC4_uc011btj.1_Silent_p.A39A|MUC4_uc011btk.1_5'UTR|MUC4_uc011btl.1_5'UTR|MUC4_uc011btm.1_Silent_p.A39A|MUC4_uc011btn.1_5'UTR|MUC4_uc003fvo.2_Silent_p.A62A|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Silent_p.A910A	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1055					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGGTGTGCATGGCAGTGCTGG	0.587													19	29					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3101041	3101041	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:3101041G>A	uc011bvq.1	+	4	539	c.394G>A	c.(394-396)GAA>AAA	p.E132K		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	130					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CATCGCTATGGAACTTTTTCT	0.313													30	33					0	0	1	0	0
EVC	2121	broad.mit.edu	37	4	5785332	5785332	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:5785332C>T	uc003gil.1	+	12	1801	c.1617C>T	c.(1615-1617)TTC>TTT	p.F539F	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	539					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				ATGCCCTGTTCCTTCAGACGC	0.592													40	49					0	0	1	0	0
LAP3	51056	broad.mit.edu	37	4	17609198	17609198	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:17609198C>T	uc003gph.1	+	13	1708	c.1546C>T	c.(1546-1548)CAA>TAA	p.Q516*		NM_015907	NP_056991	P28838	AMPL_HUMAN	leucine aminopeptidase 3	516					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding				0						TCGTTTCAGTCAAGACAATGC	0.388													20	24					0	0	1	0	0
LGI2	55203	broad.mit.edu	37	4	25005285	25005285	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:25005285G>A	uc003grf.2	-	8	1525	c.1426C>T	c.(1426-1428)CAC>TAC	p.H476Y		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	476	EAR 6.					extracellular region					0		Breast(46;0.173)				GCCAGGTAGTGATTATCTTTA	0.483													51	65					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25806357	25806357	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:25806357C>T	uc003gru.3	-	10	1734	c.1582G>A	c.(1582-1584)GAA>AAA	p.E528K	SEL1L3_uc003grv.2_5'UTR	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	528						integral to membrane	binding				0						GATACAGATTCATTTTGGTTC	0.388													9	18					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36115827	36115827	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:36115827C>T	uc003gsq.1	-	26	4459	c.4121G>A	c.(4120-4122)TGG>TAG	p.W1374*		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1374	Ras-associating.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AAATGTGGCCCAAATATCACC	0.294													36	67					0	0	1	0	0
KLF3	51274	broad.mit.edu	37	4	38690482	38690482	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:38690482C>T	uc003gth.3	+	3	666	c.334C>T	c.(334-336)CCA>TCA	p.P112S	KLF3_uc003gtg.2_Missense_Mutation_p.P112S	NM_016531	NP_057615	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	112	Pro-rich.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						ACCCCCTTCTCCAGGCGTGCA	0.627													29	39					0	0	1	0	0
N4BP2	55728	broad.mit.edu	37	4	40104609	40104609	+	Missense_Mutation	SNP	C	T	T	rs142570098	by1000genomes	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:40104609C>T	uc003guy.3	+	4	1482	c.1144C>T	c.(1144-1146)CCT>TCT	p.P382S	N4BP2_uc010ifq.2_Missense_Mutation_p.P302S|N4BP2_uc010ifr.2_Missense_Mutation_p.P302S	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	382						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						CTTTGTAGCTCCTGTTGTAAC	0.473													34	57					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40356374	40356374	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:40356374G>A	uc003gva.1	+	5	1293	c.1277G>A	c.(1276-1278)AGG>AAG	p.R426K		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	426	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	GTGCTGACGAGGAATATTGAG	0.498													17	13					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47556855	47556855	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:47556855A>T	uc003gxk.1	+	11	1912	c.1748A>T	c.(1747-1749)TAC>TTC	p.Y583F	ATP10D_uc003gxl.1_Intron	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	583	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GAAACTTTGTACATTATCGAC	0.413													26	28					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47593379	47593379	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:47593379C>T	uc003gxk.1	+	23	4426	c.4262C>T	c.(4261-4263)TCC>TTC	p.S1421F	ATP10D_uc003gxl.1_Missense_Mutation_p.S669F	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1421	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GCTGGACCCTCCAAAGGTAAA	0.433													36	55					0	0	1	0	0
TXK	7294	broad.mit.edu	37	4	48082087	48082087	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:48082087G>A	uc003gxx.3	-	11	1101	c.1015C>T	c.(1015-1017)CTT>TTT	p.L339F	TXK_uc010igj.2_RNA|TXK_uc011bzj.1_Missense_Mutation_p.L26F	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	339	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						ACAATGTAAAGGGGCTTCCGC	0.413													25	33					0	0	1	0	0
GSX2	170825	broad.mit.edu	37	4	54967854	54967854	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:54967854T>C	uc010igp.1	+	2	944	c.680T>C	c.(679-681)CTG>CCG	p.L227P	PDGFRA_uc003haa.2_Intron	NM_133267	NP_573574	Q9BZM3	GSX2_HUMAN	GS homeobox 2	227	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			AACATGTACCTGTCTCGACTC	0.532													3	104					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55153697	55153697	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:55153697T>A	uc003han.3	+	19	2994	c.2663T>A	c.(2662-2664)ATC>AAC	p.I888N	PDGFRA_uc003haa.2_Missense_Mutation_p.I648N	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	888	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTCTGGGAGATCTTTTCCCTT	0.488			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			44	49					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55955603	55955603	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:55955603T>G	uc003has.2	-	25	3644	c.3342A>C	c.(3340-3342)GAA>GAC	p.E1114D	KDR_uc003hat.1_Missense_Mutation_p.E1114D	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1114	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GCCTACAAAATTCTTCATCAA	0.378			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			16	20					0	0	1	0	0
AASDH	132949	broad.mit.edu	37	4	57216218	57216218	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:57216218G>A	uc003hbn.2	-	11	1852	c.1699C>T	c.(1699-1701)CTG>TTG	p.L567L	AASDH_uc010ihb.2_Silent_p.L82L|AASDH_uc011caa.1_Silent_p.L414L|AASDH_uc003hbo.2_Silent_p.L467L|AASDH_uc011cab.1_Silent_p.L82L|AASDH_uc010ihc.2_Silent_p.L567L|AASDH_uc003hbp.2_Silent_p.L567L	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	567	Acyl carrier.				fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				GGGAGATTCAGAGTAGACTAC	0.388													3	6					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68934466	68934466	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:68934466C>T	uc003hdt.1	-	7	674	c.625G>A	c.(625-627)GGA>AGA	p.G209R	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	209	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GTTTCCCTTCCTTGGACAATT	0.483													17	41					0	0	1	0	0
Unknown	0	broad.mit.edu	37	4	69343096	69343096	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:69343096C>T	uc003hdz.3	+	8	781	c.717C>T	c.(715-717)AAC>AAT	p.N239N		NM_014058	NP_054777			transmembrane protease, serine 11E																		GATATAAGAACCCTGCCAGAT	0.343													39	86					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69884075	69884075	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:69884075C>T	uc011cao.1	-	5	774	c.638G>A	c.(637-639)AGG>AAG	p.R213K	UGT2B10_uc011can.1_Missense_Mutation_p.R129K			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	250					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GTCAGCTTTTCCCATTGTCTC	0.358													39	52					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70078409	70078409	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:70078409C>T	uc003heh.2	-	2	761	c.752G>A	c.(751-753)GGA>GAA	p.G251E	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	251					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						GTCAGCTTTTCCCATTGTCTC	0.373													25	55					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156420	70156420	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:70156420G>A	uc003hej.2	+	5	1203	c.1201G>A	c.(1201-1203)GAT>AAT	p.D401N	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	401					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	GGATCAACCTGATAACATTGC	0.453													49	40					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70346374	70346374	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:70346374C>T	uc003hek.3	-	6	1612	c.1565G>A	c.(1564-1566)GGA>GAA	p.G522E	UGT2B4_uc011cap.1_Missense_Mutation_p.G386E|UGT2B4_uc003hel.3_3'UTR	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	522					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CCCCTTCTTTCCTGTTCTAAC	0.413													30	43					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361388	70361388	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:70361388G>A	uc003hek.3	-	1	239	c.192C>T	c.(190-192)TTC>TTT	p.F64F	UGT2B4_uc011cap.1_Intron|UGT2B4_uc003hel.3_Silent_p.F64F	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	64					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TGTTGGGATCGAAAGAAATGG	0.398													28	45					0	0	1	0	0
SMR3B	10879	broad.mit.edu	37	4	71255479	71255479	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:71255479C>T	uc011cas.1	+	3	235	c.154C>T	c.(154-156)CCA>TCA	p.P52S	SMR3B_uc003hfh.2_Missense_Mutation_p.P52S	NM_006685	NP_006676	P02814	SMR3B_HUMAN	submaxillary gland androgen regulated protein 3	52	Poly-Pro.|Pro-rich.					extracellular space				skin(1)	1		all_hematologic(202;0.196)				ACCTCCTCCTCCACCCTATGG	0.602													24	48					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74285287	74285287	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:74285287G>A	uc003hgs.3	+	13	1789	c.1716G>A	c.(1714-1716)ATG>ATA	p.M572I	ALB_uc003hgw.3_Missense_Mutation_p.M380I|ALB_uc011cbe.1_Missense_Mutation_p.M251I|ALB_uc003hgt.3_Missense_Mutation_p.M572I|ALB_uc010iii.2_Missense_Mutation_p.M457I|ALB_uc003hgu.3_Missense_Mutation_p.M422I|ALB_uc003hgv.3_Missense_Mutation_p.M251I|ALB_uc011cbf.1_Missense_Mutation_p.M462I|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Missense_Mutation_p.M251I	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	572	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AAGCTGTTATGGATGATTTCG	0.413													16	33					0	0	1	0	0
AFM	173	broad.mit.edu	37	4	74347574	74347574	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:74347574G>A	uc003hhb.2	+	1	113	c.82G>A	c.(82-84)GAT>AAT	p.D28N		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	28	Albumin 1.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ACAACCTCGGGATATAGGTAA	0.294													14	20					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77247155	77247155	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:77247155C>T	uc003hkb.3	-	22	3165	c.3012G>A	c.(3010-3012)GTG>GTA	p.V1004V		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	1004	Ser-rich.									skin(3)|ovary(2)|pancreas(1)	6						CTGAGTTTTTCACAGATGGAC	0.368													44	75					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328149	80328149	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:80328149G>A	uc003hlu.2	-	1	1224	c.1206C>T	c.(1204-1206)TTC>TTT	p.F402F		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	402					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						CTCGGGTTTGGAAACAAACAG	0.443													34	44					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328422	80328422	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:80328422C>T	uc003hlu.2	-	1	951	c.933G>A	c.(931-933)GAG>GAA	p.E311E		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	311					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						ATGCTGGCTTCTCTCTGCCTA	0.433													35	42					0	0	1	0	0
FGF5	2250	broad.mit.edu	37	4	81207778	81207778	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:81207778G>A	uc003hmd.2	+	3	996	c.759G>A	c.(757-759)CGG>CGA	p.R253R	FGF5_uc003hme.2_3'UTR	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	253					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						CTGCACCTCGGAAAAATACCA	0.438													21	27					0	0	1	0	0
C4orf22	255119	broad.mit.edu	37	4	81791175	81791175	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:81791175C>T	uc003hmf.2	+	4	411	c.362C>T	c.(361-363)TCT>TTT	p.S121F	C4orf22_uc010ijp.2_Missense_Mutation_p.S138F	NM_152770	NP_689983	Q6V702	CD022_HUMAN	hypothetical protein LOC255119	121										skin(2)	2						GACAGAAATTCTCATGGGCAA	0.373													40	34					0	0	1	0	0
RASGEF1B	153020	broad.mit.edu	37	4	82366918	82366918	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:82366918C>T	uc003hmi.1	-	7	948	c.804G>A	c.(802-804)TTG>TTA	p.L268L	RASGEF1B_uc003hmj.1_Silent_p.L267L|RASGEF1B_uc010ijq.1_Silent_p.L226L	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	268	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						CTGTAGCAACCAAGTAGCTGA	0.363													10	15					0	0	1	0	0
ENOPH1	58478	broad.mit.edu	37	4	83372251	83372251	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:83372251A>C	uc003hmv.2	+	3	499	c.242A>C	c.(241-243)AAT>ACT	p.N81T	ENOPH1_uc003hmw.2_5'UTR|ENOPH1_uc003hmx.2_Intron	NM_021204	NP_067027	Q9UHY7	ENOPH_HUMAN	enolase-phosphatase 1	81					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity				0						GCATCTGGGAATGGAGTGGAT	0.488													30	41					0	0	1	0	0
NKX6-1	4825	broad.mit.edu	37	4	85414682	85414682	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:85414682C>T	uc003hpa.1	-	3	870	c.864G>A	c.(862-864)CGG>CGA	p.R288R		NM_006168	NP_006159	P78426	NKX61_HUMAN	NK6 transcription factor related, locus 1	288	Homeobox.				detection of glucose|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|type B pancreatic cell maturation	nucleus					0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.0013)		TCCACTTGGTCCGGCGGTTCT	0.617													20	35					0	0	1	0	0
HSD17B13	345275	broad.mit.edu	37	4	88243985	88243985	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:88243985G>A	uc003hqo.2	-	1	72	c.9C>T	c.(7-9)ATC>ATT	p.I3I	HSD17B13_uc010ikk.2_Silent_p.I3I	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	3						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		TTTCTAGGATGATGTTCATGG	0.488													8	13					0	0	1	0	0
MEPE	56955	broad.mit.edu	37	4	88767428	88767428	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:88767428C>T	uc003hqy.2	+	4	1447	c.1408C>T	c.(1408-1410)CAT>TAT	p.H470Y	MEPE_uc010ikn.2_Missense_Mutation_p.H357Y	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	470					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		CAGAAAATATCATTATGTACC	0.418													21	33					0	0	1	0	0
ADH1B	125	broad.mit.edu	37	4	100235037	100235037	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:100235037C>T	uc003hus.3	-	6	853	c.769G>A	c.(769-771)GAA>AAA	p.E257K	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Missense_Mutation_p.E217K|ADH1B_uc011ceh.1_Missense_Mutation_p.E102K|ADH1B_uc011cei.1_Missense_Mutation_p.E217K	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	257					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	TCAGTCATTTCCTTTAGCACT	0.463													100	120					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100266220	100266220	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:100266220C>T	uc003huu.2	-	7	451	c.366G>A	c.(364-366)GGG>GGA	p.G122G		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	122					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	CCTGCAGGGTCCCCCGAGGAT	0.537									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				19	37					0	0	1	0	0
NFKB1	4790	broad.mit.edu	37	4	103516075	103516075	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:103516075C>T	uc011ceq.1	+	13	1701	c.1234C>T	c.(1234-1236)CCT>TCT	p.P412S	NFKB1_uc011cep.1_Missense_Mutation_p.P413S|NFKB1_uc011cer.1_Missense_Mutation_p.P232S	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	412	Gly-rich.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	CTATGGATTTCCTACTTATGG	0.373													14	16					0	0	1	0	0
CXXC4	80319	broad.mit.edu	37	4	105411974	105411974	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:105411974C>T	uc003hxg.2	-	1	494	c.479G>A	c.(478-480)CGC>CAC	p.R160H	uc003hxh.1_5'Flank|CXXC4_uc010ilo.2_Intron	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	CXXC finger 4	160	CXXC-type.				negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		TCCCGTTTTGCGGTTCCTGCA	0.507													4	69					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122853716	122853716	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:122853716C>T	uc003ieg.2	-	2	771	c.697G>A	c.(697-699)GAC>AAC	p.D233N	TRPC3_uc010inr.2_Missense_Mutation_p.D160N|TRPC3_uc003ief.2_Missense_Mutation_p.D160N|TRPC3_uc011cgl.1_5'UTR	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	148	Cytoplasmic (Potential).|ANK 4.				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						GGGGTGATGTCCGGCGAGAAG	0.617													24	27					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123160823	123160823	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:123160823A>T	uc003ieh.2	+	27	4031	c.3986A>T	c.(3985-3987)TAT>TTT	p.Y1329F	KIAA1109_uc003iei.1_Missense_Mutation_p.Y1082F|KIAA1109_uc010ins.1_Missense_Mutation_p.Y672F|KIAA1109_uc003iek.2_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1329					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GCTGCTTTCTATGGGGACAAG	0.453													23	34					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372792	126372792	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:126372792C>T	uc003ifj.3	+	9	10621	c.10621C>T	c.(10621-10623)CAA>TAA	p.Q3541*	FAT4_uc011cgp.1_Nonsense_Mutation_p.Q1839*|FAT4_uc003ifi.1_Nonsense_Mutation_p.Q1019*	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3541	Cadherin 34.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCCTCCAAATCAAGGTCCCTT	0.502													47	77					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126412372	126412372	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:126412372C>T	uc003ifj.3	+	17	14395	c.14395C>T	c.(14395-14397)CGC>TGC	p.R4799C	FAT4_uc011cgp.1_Missense_Mutation_p.R3040C|FAT4_uc003ifi.1_Missense_Mutation_p.R2276C	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4799	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CAACACACCTCGCCCTAGAAA	0.532													38	46					0	0	1	0	0
PHF17	79960	broad.mit.edu	37	4	129778548	129778548	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:129778548C>T	uc003igk.2	+	8	1200	c.920C>T	c.(919-921)CCC>CTC	p.P307L	PHF17_uc003igj.2_Missense_Mutation_p.P307L|PHF17_uc003igl.2_Missense_Mutation_p.P295L|PHF17_uc011cgy.1_Missense_Mutation_p.P307L|PHF17_uc003igm.2_Missense_Mutation_p.P307L	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	307					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						TCACACATTCCCAGCAGCCGG	0.517													67	120					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153864541	153864541	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:153864541G>A	uc003inf.2	+	1	407	c.332G>A	c.(331-333)CGA>CAA	p.R111Q		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	111	FH2.				actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					GAGCAAGTTCGAGGCAAAACC	0.493													62	98					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507651	155507651	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:155507651A>G	uc003iod.1	-	5	988	c.930T>C	c.(928-930)CCT>CCC	p.P310P	FGA_uc003ioe.1_Silent_p.P310P|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	310	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CAGAGCTCCCAGGGTTTCGGT	0.572													51	56					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156643259	156643259	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:156643259C>T	uc003iov.2	+	10	2322	c.1786C>T	c.(1786-1788)CTT>TTT	p.L596F	GUCY1A3_uc010iqc.2_Missense_Mutation_p.L596F|GUCY1A3_uc003iow.2_Missense_Mutation_p.L596F|GUCY1A3_uc010iqd.2_Missense_Mutation_p.L595F|GUCY1A3_uc003iox.2_Missense_Mutation_p.L596F|GUCY1A3_uc003ioz.2_Missense_Mutation_p.L361F|GUCY1A3_uc003ioy.2_Missense_Mutation_p.L596F|GUCY1A3_uc010iqe.2_Missense_Mutation_p.L361F|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.L596F	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	596	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CCGTTACTGTCTTTTTGGAAA	0.408													41	77					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160277080	160277080	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:160277080C>T	uc003iqg.3	+	23	4554	c.4244C>T	c.(4243-4245)CCA>CTA	p.P1415L		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	1415					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		ACTGACTTTCCAGAAGGGCAC	0.587													3	5					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162307269	162307269	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:162307269C>T	uc003iqh.2	-	16	2610	c.2174G>A	c.(2173-2175)GGA>GAA	p.G725E	FSTL5_uc003iqi.2_Missense_Mutation_p.G724E|FSTL5_uc010iqv.2_Missense_Mutation_p.G715E|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	725						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CTGTATTTCTCCTCTGATGGT	0.423													32	27					0	0	1	0	0
ANP32C	23520	broad.mit.edu	37	4	165118746	165118746	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:165118746C>T	uc011cjk.1	-	1	118	c.118G>A	c.(118-120)GAA>AAA	p.E40K	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	40											0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		TCTTCAAATTCATCTGTGAGG	0.453													57	65					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169172115	169172115	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:169172115C>T	uc003irp.2	-	28	4140	c.3848G>A	c.(3847-3849)GGA>GAA	p.G1283E		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1283	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CCTAAGATATCCTTTTCTAAA	0.333													16	15					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169176921	169176921	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:169176921G>A	uc003irp.2	-	26	3790	c.3498C>T	c.(3496-3498)GCC>GCT	p.A1166A		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1166							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CCATGACATGGGCTTCTTTAT	0.363													22	28					0	0	1	0	0
SH3RF1	57630	broad.mit.edu	37	4	170028325	170028325	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:170028325G>A	uc003isa.1	-	11	2506	c.2171C>T	c.(2170-2172)TCT>TTT	p.S724F		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	724						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		GGAGGCGCCAGAAAGCAACTT	0.502													20	17					0	0	1	0	0
VEGFC	7424	broad.mit.edu	37	4	177608657	177608657	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:177608657G>A	uc003ius.1	-	6	1259	c.829C>T	c.(829-831)CAT>TAT	p.H277Y		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	277					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		CAGATGTCATGGAATCCATCT	0.468													7	7					0	0	1	0	0
ODZ3	55714	broad.mit.edu	37	4	183717789	183717789	+	Splice_Site	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:183717789G>A	uc003ivd.1	+	26	7251	c.7214_splice	c.e26-1	p.D2405_splice		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3						signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TCTTCTCCTAGATGTTAACAG	0.343													10	24					0	0	1	0	0
ZDHHC11	79844	broad.mit.edu	37	5	840728	840728	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:840728G>A	uc011cma.1	-	5	1050	c.666C>T	c.(664-666)CCC>CCT	p.P222P	ZDHHC11_uc003jbj.2_RNA|ZDHHC11_uc010itd.1_RNA|ZDHHC11_uc003jbk.2_Silent_p.P9P	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	222						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			CCGGGAACAGGGGGAGGAACA	0.592													89	269					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1208996	1208996	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:1208996G>A	uc003jbw.3	+	2	394	c.338G>A	c.(337-339)GGC>GAC	p.G113D		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	113	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCCCTGAAGGGCCTAGGTGAG	0.716													20	16					0	0	1	0	0
FASTKD3	79072	broad.mit.edu	37	5	7868072	7868072	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:7868072C>T	uc003jeb.2	-	2	262	c.125G>A	c.(124-126)TGC>TAC	p.C42Y	FASTKD3_uc011cmp.1_5'UTR|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	42					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						CAACCAAGGGCACAGACGCTC	0.403													30	53					0	0	1	0	0
CMBL	134147	broad.mit.edu	37	5	10288574	10288574	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:10288574G>A	uc003jes.2	-	3	734	c.283C>T	c.(283-285)CCT>TCT	p.P95S		NM_138809	NP_620164	Q96DG6	CMBL_HUMAN	carboxymethylenebutenolidase	95						cytosol	hydrolase activity|protein binding			skin(1)	1						AGCCACTCAGGGAAGATAGAC	0.502													17	44					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13717505	13717505	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:13717505G>A	uc003jfd.2	-	73	12666	c.12624C>T	c.(12622-12624)ATC>ATT	p.I4208I	DNAH5_uc003jfc.2_Silent_p.I376I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4208	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATTCGTAGGGGATATTCCACC	0.542									Kartagener_syndrome				10	18					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13717507	13717507	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:13717507T>A	uc003jfd.2	-	73	12664	c.12622A>T	c.(12622-12624)ATC>TTC	p.I4208F	DNAH5_uc003jfc.2_Missense_Mutation_p.I376F	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4208	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCGTAGGGGATATTCCACCCC	0.542									Kartagener_syndrome				10	19					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13727622	13727622	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:13727622G>A	uc003jfd.2	-	70	12069	c.12027C>T	c.(12025-12027)ATC>ATT	p.I4009I	DNAH5_uc003jfc.2_Silent_p.I177I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4009					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTACCTGGGCGATGGTTCTGT	0.323									Kartagener_syndrome				15	19					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13776797	13776797	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:13776797G>A	uc003jfd.2	-	55	9166	c.9124C>T	c.(9124-9126)CGA>TGA	p.R3042*		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3042	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATTTCATCTCGAGCAAATAGG	0.383									Kartagener_syndrome				29	35					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13794139	13794139	+	Missense_Mutation	SNP	C	T	T	rs140968268		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:13794139C>T	uc003jfd.2	-	48	7958	c.7916G>A	c.(7915-7917)CGA>CAA	p.R2639Q		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2639	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.R2639Q(1)		ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGTACCCATTCGTTTATCCAC	0.368									Kartagener_syndrome				20	25					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21854849	21854849	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:21854849C>T	uc010iuc.2	-	4	1035	c.577G>A	c.(577-579)GGA>AGA	p.G193R	CDH12_uc011cno.1_Intron|CDH12_uc003jgk.2_Missense_Mutation_p.G193R	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	193	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GCACTGTTTCCATAGGTCGGG	0.393										HNSCC(59;0.17)			16	16					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24492992	24492992	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:24492992C>T	uc003jgr.1	-	10	1890	c.1558G>A	c.(1558-1560)GGT>AGT	p.G520S	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	520	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TTCTGTCCACCTAAAGGGTCA	0.328										HNSCC(23;0.051)			74	88					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31313487	31313487	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:31313487C>T	uc003jhe.1	+	8	1642	c.1316C>T	c.(1315-1317)TCG>TTG	p.S439L	CDH6_uc003jhd.1_Missense_Mutation_p.S439L	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	439	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						GGAAATGGTTCGATTTTTACA	0.393													30	44					0	0	1	0	0
RNASEN	29102	broad.mit.edu	37	5	31521270	31521270	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:31521270G>A	uc003jhg.2	-	5	1266	c.907C>T	c.(907-909)CTG>TTG	p.L303L	RNASEN_uc003jhh.2_Silent_p.L303L|RNASEN_uc003jhi.2_Silent_p.L303L|RNASEN_uc010iui.1_Intron	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	303	Arg-rich.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						GACCTTTCCAGAGATGGTGAT	0.403													76	94					0	0	1	0	0
C5orf23	79614	broad.mit.edu	37	5	32789636	32789636	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:32789636G>A	uc003jhw.1	+	1	692	c.129G>A	c.(127-129)GGG>GGA	p.G43G		NM_024563	NP_078839			hypothetical protein LOC79614												0						TTAATGGAGGGAAGAGAGAAA	0.408													28	23					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33546244	33546244	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:33546244C>T	uc003jia.1	-	22	4529	c.4366G>A	c.(4366-4368)GAT>AAT	p.D1456N	ADAMTS12_uc010iuq.1_Missense_Mutation_p.D1371N	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1456	TSP type-1 7.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TTTGTCCAATCACAGAGGCCT	0.507										HNSCC(64;0.19)			20	29					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35026574	35026574	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:35026574C>T	uc003jjf.2	-	8	890	c.811G>A	c.(811-813)GAT>AAT	p.D271N	AGXT2_uc003jje.1_5'Flank|AGXT2_uc011com.1_Missense_Mutation_p.D271N	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	271					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	CTCAGCGTATCTTTGAATTGC	0.393													7	26					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35086390	35086390	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:35086390C>T	uc003jjm.2	-	4	653	c.123G>A	c.(121-123)AAG>AAA	p.K41K	PRLR_uc003jjg.1_Silent_p.K41K|PRLR_uc003jjh.1_Silent_p.K41K|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Silent_p.K41K|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Intron|PRLR_uc010iuw.1_5'UTR	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	41	Fibronectin type-III 1.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGAATGTTTCCTTATTGGGAG	0.458													22	33					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38418213	38418213	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:38418213G>A	uc003jlc.1	+	12	1864	c.1540G>A	c.(1540-1542)GGC>AGC	p.G514S	EGFLAM_uc003jlb.1_Missense_Mutation_p.G514S|EGFLAM_uc003jle.1_Missense_Mutation_p.G280S|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	514	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					CTATCTTGGTGGCGCTCCCAG	0.463													20	44					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40854128	40854128	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:40854128C>T	uc003jmg.2	+	3	2769	c.2694C>T	c.(2692-2694)TCC>TCT	p.S898S		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	898					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						ACCCTCAGTCCTTTCAACCAG	0.483													34	53					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40959559	40959559	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:40959559G>A	uc003jmh.2	+	12	1612	c.1498G>A	c.(1498-1500)GAT>AAT	p.D500N	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	500	TSP type-1 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				AGGAGGGGTTGATGGAGGTTG	0.488													11	5					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41181522	41181522	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:41181522C>T	uc003jmk.2	-	7	1076	c.866G>A	c.(865-867)AGA>AAA	p.R289K	C6_uc003jml.1_Missense_Mutation_p.R289K	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	289	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ATTTTCACTTCTCTTTGAGGA	0.363													23	47					0	0	1	0	0
FBXO4	26272	broad.mit.edu	37	5	41934071	41934071	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:41934071C>T	uc003jmq.2	+	4	726	c.670C>T	c.(670-672)CAG>TAG	p.Q224*	FBXO4_uc003jmp.2_Nonsense_Mutation_p.Q224*|FBXO4_uc003jmr.2_Nonsense_Mutation_p.Q224*	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	224					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				AGTCAATTTTCAGTTGAACAA	0.323													15	26					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49706744	49706744	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:49706744C>T	uc003jom.2	-	4	688	c.439G>A	c.(439-441)GAA>AAA	p.E147K	EMB_uc003jol.2_Missense_Mutation_p.E78K|EMB_uc011cpy.1_Missense_Mutation_p.E97K|EMB_uc010ivr.2_Missense_Mutation_p.E93K	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	147	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TGTTCCTTTTCCTCTCGAAAG	0.308													11	16					0	0	1	0	0
GPBP1	65056	broad.mit.edu	37	5	56526749	56526749	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:56526749A>T	uc003jrh.3	+	4	1414	c.140A>T	c.(139-141)CAC>CTC	p.H47L	GPBP1_uc010iwg.2_Missense_Mutation_p.H47L|GPBP1_uc003jri.3_5'UTR|GPBP1_uc003jrj.3_Missense_Mutation_p.H54L|GPBP1_uc003jrk.3_Missense_Mutation_p.H54L|GPBP1_uc003jrl.3_RNA	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		CGTCGACGACACAACTCTTCA	0.348													37	44					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75993836	75993836	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:75993836C>T	uc003kek.2	+	33	4453	c.4231C>T	c.(4231-4233)CGT>TGT	p.R1411C	IQGAP2_uc011csv.1_Missense_Mutation_p.R907C|IQGAP2_uc003kel.2_Missense_Mutation_p.R907C|IQGAP2_uc010izw.1_Missense_Mutation_p.R112C	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1411					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AAGAATCTATCGTAAGCTTCG	0.353													6	12					0	0	1	0	0
F2R	2149	broad.mit.edu	37	5	76028361	76028361	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:76028361T>A	uc003ken.3	+	2	576	c.311T>A	c.(310-312)TTT>TAT	p.F104Y		NM_001992	NP_001983	P25116	PAR1_HUMAN	coagulation factor II receptor precursor	104	Helical; Name=1; (Potential).				activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			ovary(3)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	CTGACACTCTTTGTCCCATCT	0.468													35	71					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031294	79031294	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:79031294C>T	uc003kgc.2	+	2	6778	c.6706C>T	c.(6706-6708)CAT>TAT	p.H2236Y		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2236						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ACCAGCTGATCATTCATTATC	0.378													34	74					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95757591	95757591	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:95757591C>T	uc003kls.1	-	5	819	c.613G>A	c.(613-615)GAG>AAG	p.E205K		NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	205	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CACTTGTTCTCGTTTGTGGGA	0.338													56	69					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834246	101834246	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:101834246A>G	uc003knn.2	-	1	475	c.303T>C	c.(301-303)TGT>TGC	p.C101C	SLCO6A1_uc003kno.2_Silent_p.C101C|SLCO6A1_uc003knp.2_Silent_p.C101C|SLCO6A1_uc003knq.2_Silent_p.C101C	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	101	Cytoplasmic (Potential).|Cys-rich.					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TGTTATTGCAACACTCACAGC	0.522													23	39					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834439	101834439	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:101834439C>T	uc003knn.2	-	1	282	c.110G>A	c.(109-111)GGA>GAA	p.G37E	SLCO6A1_uc003kno.2_Missense_Mutation_p.G37E|SLCO6A1_uc003knp.2_Missense_Mutation_p.G37E|SLCO6A1_uc003knq.2_Missense_Mutation_p.G37E	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	37	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CTTCGGGGTTCCCTTGGCCCT	0.607													52	92					0	0	1	0	0
TRIM36	55521	broad.mit.edu	37	5	114472711	114472711	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:114472711G>A	uc003kqs.2	-	7	1741	c.1232C>T	c.(1231-1233)TCC>TTC	p.S411F	TRIM36_uc011cwc.1_Missense_Mutation_p.S399F|TRIM36_uc003kqt.2_Missense_Mutation_p.S256F	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	411	COS.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		AGAGAAAAAGGATAATTCTCC	0.348													12	16					0	0	1	0	0
AQPEP	206338	broad.mit.edu	37	5	115336332	115336332	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:115336332G>A	uc003kro.2	+	9	1788	c.1624G>A	c.(1624-1626)GAT>AAT	p.D542N	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	542	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TGAGCAAGATGATCTATGGAG	0.353													14	23					0	0	1	0	0
DTWD2	285605	broad.mit.edu	37	5	118264253	118264253	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:118264253G>A	uc003ksa.2	-	4	610	c.576C>T	c.(574-576)TCC>TCT	p.S192S		NM_173666	NP_775937	Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	192											0		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)		GTCGGAACAAGGAGTTCTTAT	0.254													26	25					0	0	1	0	0
HSD17B4	3295	broad.mit.edu	37	5	118835027	118835027	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:118835027C>T	uc003ksj.2	+	13	1111	c.988C>T	c.(988-990)CAG>TAG	p.Q330*	HSD17B4_uc011cwg.1_Nonsense_Mutation_p.Q306*|HSD17B4_uc011cwh.1_Nonsense_Mutation_p.Q312*|HSD17B4_uc011cwi.1_Nonsense_Mutation_p.Q355*|HSD17B4_uc003ksk.3_Nonsense_Mutation_p.Q183*|HSD17B4_uc011cwj.1_Nonsense_Mutation_p.Q183*|HSD17B4_uc010jcn.1_Nonsense_Mutation_p.Q68*	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	330	Enoyl-CoA hydratase 2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	AGCTATTGGCCAGAAACTCCC	0.338													15	27					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121758805	121758805	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:121758805G>A	uc003ksw.1	+	4	579	c.373G>A	c.(373-375)GGA>AGA	p.G125R	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.G125R|SNCAIP_uc003ksx.1_Missense_Mutation_p.G172R|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Missense_Mutation_p.G125R	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	125					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CCCTGGAGATGGAGTGGGCGG	0.562													17	21					0	0	1	0	0
PPIC	5480	broad.mit.edu	37	5	122365030	122365030	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:122365030C>T	uc003kth.2	-	2	306	c.201G>A	c.(199-201)GTG>GTA	p.V67V	PPIC_uc011cwp.1_Silent_p.V67V	NM_000943	NP_000934	P45877	PPIC_HUMAN	peptidylprolyl isomerase C	67	PPIase cyclophilin-type.				protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			ovary(1)	1		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	CAAAATTTTCCACTGTCTTGG	0.388													16	49					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126754902	126754903	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:126754902_126754903CC>TT	uc003kuh.3	+	12	1758_1759	c.1396_1397CC>TT	c.(1396-1398)CCT>TTT	p.P466F	MEGF10_uc010jdc.1_Missense_Mutation_p.P466F|MEGF10_uc010jdd.1_Missense_Mutation_p.P466F|MEGF10_uc003kui.3_Missense_Mutation_p.P466F	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	466	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EGF-like 8.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGTCTGCTCTCCTGTGGACGGG	0.45													39	57					0	0	1	0	0
CHSY3	337876	broad.mit.edu	37	5	129521409	129521409	+	Silent	SNP	C	T	T	rs148231534		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:129521409C>T	uc003kvd.2	+	3	2574	c.2574C>T	c.(2572-2574)TTC>TTT	p.F858F		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	858	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		CAAGTACTTTCGCCTCAACCA	0.443													23	34					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132585262	132585262	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:132585262A>G	uc003kyn.1	-	7	952	c.734T>C	c.(733-735)GTT>GCT	p.V245A		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	245						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCTGAGCTGAACCACTTCTGC	0.597											OREG0005128	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	6	18					0	0	1	0	0
EGR1	1958	broad.mit.edu	37	5	137803563	137803563	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:137803563C>T	uc003ldb.1	+	2	1695	c.1425C>T	c.(1423-1425)TCC>TCT	p.S475S	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	475					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			cctccttctcctctcccggct	0.239													50	43					0	0	1	0	0
CXXC5	51523	broad.mit.edu	37	5	139060348	139060348	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:139060348C>T	uc010jfg.1	+	2	530	c.240C>T	c.(238-240)TCC>TCT	p.S80S	CXXC5_uc003let.2_Silent_p.S80S	NM_016463	NP_057547	Q7LFL8	CXXC5_HUMAN	CXXC finger 5	80					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCGCTCTCCCACTACTCTT	0.642													33	74					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187629	140187629	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140187629C>T	uc003lhi.2	+	1	958	c.857C>T	c.(856-858)TCG>TTG	p.S286L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.S286L|PCDHA4_uc011daa.1_Missense_Mutation_p.S286L	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	286	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding	p.S286L(1)		ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGATATTTCGCCAAATGTG	0.313													20	33					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140223213	140223213	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140223213C>T	uc003lhs.2	+	1	2307	c.2307C>T	c.(2305-2307)CTC>CTT	p.L769L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.L769L	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	769	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACGGACCTCATGGCCTTCA	0.552													19	23					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307121	140307121	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140307121G>A	uc003lih.2	+	1	820	c.644G>A	c.(643-645)GGA>GAA	p.G215E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.G215E	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	215	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCGCTCAGGAGACGCACAA	0.587													16	31					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140308647	140308647	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140308647G>A	uc003lih.2	+	1	2346	c.2170G>A	c.(2170-2172)GAT>AAT	p.D724N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.D724N	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	724	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTACAGAGGATCTGAGGTA	0.453													22	40					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347843	140347843	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140347843G>A	uc003lii.2	+	1	1732	c.1492G>A	c.(1492-1494)GAA>AAA	p.E498K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.E498K	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	498	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACCCAGATGAAAAGGAGAA	0.512													40	62					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432758	140432758	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140432758A>G	uc003lik.1	+	1	1780	c.1703A>G	c.(1702-1704)AAC>AGC	p.N568S		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	568	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCACTGCAGAACGGCACCTTG	0.522													27	31					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475643	140475643	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140475643C>T	uc003lil.2	+	1	1407	c.1269C>T	c.(1267-1269)ATC>ATT	p.I423I	PCDHB2_uc003lim.1_Silent_p.I84I	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	423	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACATCACCATCACCGTCACCG	0.522													27	40					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516537	140516537	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140516537G>A	uc003liq.2	+	1	1738	c.1521G>A	c.(1519-1521)GCG>GCA	p.A507A		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	507	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCATCAACGCGGACAACGGCC	0.677													49	49					0	0	1	0	0
PCDHB9	56127	broad.mit.edu	37	5	140568987	140568987	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140568987C>T	uc003liw.1	+	3	2096	c.2096C>T	c.(2095-2097)TCG>TTG	p.S699L	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	699	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGTGTCTTCGCTCTTCCTC	0.697													38	91					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626760	140626760	+	Silent	SNP	C	T	T	rs17844628		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140626760C>T	uc003lje.2	+	1	1614	c.1614C>T	c.(1612-1614)TTC>TTT	p.F538F		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	538	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCGCGGCTTCCCGGCGCTGA	0.672													32	32					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140740708	140740708	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140740708G>A	uc003ljs.1	+	1	1006	c.1006G>A	c.(1006-1008)GAA>AAA	p.E336K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Missense_Mutation_p.E336K	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	336	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATCCAAGTTGAAATTCTTGA	0.443													13	13					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140740843	140740843	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140740843G>A	uc003ljs.1	+	1	1141	c.1141G>A	c.(1141-1143)GAA>AAA	p.E381K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Missense_Mutation_p.E381K	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	381	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAAATGGAGAAGTTTACTG	0.453													35	38					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751047	140751047	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140751047G>A	uc003ljw.1	+	1	1086	c.1086G>A	c.(1084-1086)CTG>CTA	p.L362L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Silent_p.L362L|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	362	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCTGAGCTGGGGACTGCCG	0.403													13	16					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773223	140773223	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140773223C>T	uc003lkd.1	+	1	1741	c.843C>T	c.(841-843)TTC>TTT	p.F281F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Silent_p.F281F	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	281	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATACAAATTCCGGAAAATTA	0.413													30	59					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140795001	140795001	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:140795001C>T	uc003lkl.1	+	1	2259	c.2259C>T	c.(2257-2259)TTC>TTT	p.F753F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.F753F|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	753	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGGGCTTTCCTGCAGACCT	0.627													29	47					0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141335629	141335629	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:141335629A>G	uc003llx.2	-	1	2999	c.1788T>C	c.(1786-1788)AAT>AAC	p.N596N		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	596	Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCCAAGCCATTGGGAGTCT	0.612													27	26					0	0	1	0	0
SLC26A2	1836	broad.mit.edu	37	5	149357297	149357297	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:149357297C>T	uc003lrh.2	+	2	350	c.82C>T	c.(82-84)CAT>TAT	p.H28Y		NM_000112	NP_000103	P50443	S26A2_HUMAN	solute carrier family 26 member 2	28	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ATCTGGGATCCATCTGGAACT	0.408													19	29					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154394530	154394530	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:154394530G>A	uc010jih.1	+	1	1271	c.1111G>A	c.(1111-1113)GGT>AGT	p.G371S		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	371	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGCCCATGGAGGTACCCTGCC	0.418													58	60					0	0	1	0	0
RNF145	153830	broad.mit.edu	37	5	158585695	158585695	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:158585695G>A	uc003lxp.2	-	11	2288	c.1975C>T	c.(1975-1977)CCT>TCT	p.P659S	RNF145_uc011ddy.1_Missense_Mutation_p.P673S|RNF145_uc003lxo.1_Missense_Mutation_p.P687S|RNF145_uc011ddz.1_Missense_Mutation_p.P676S|RNF145_uc010jiq.1_Missense_Mutation_p.P689S	NM_144726	NP_653327	Q96MT1	RN145_HUMAN	ring finger protein 145	659						integral to membrane	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GATTCAACAGGATGTGCTTCA	0.443													46	81					0	0	1	0	0
C1QTNF2	114898	broad.mit.edu	37	5	159776559	159776559	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:159776559C>A	uc003lyd.2	-	3	613	c.609G>T	c.(607-609)AAG>AAT	p.K203N		NM_031908	NP_114114	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	158	C1q.					collagen				skin(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTGGGTAGCTCTTGGTCACTG	0.612													44	86					1.83081e-24	1.86186e-24	1	1	0
ATP10B	23120	broad.mit.edu	37	5	160030988	160030988	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:160030988C>T	uc003lym.1	-	20	4068	c.3221G>A	c.(3220-3222)GGA>GAA	p.G1074E	ATP10B_uc010jit.1_Missense_Mutation_p.G391E	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1074	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCCTTCCTGTCCAGATATTCC	0.398													12	39					0	0	1	0	0
MIR218-2	407001	broad.mit.edu	37	5	168195207	168195207	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:168195207C>T	hsa-mir-218-2|MI0000295	-			c.54C>T			SLIT3_uc003mab.2_Intron|SLIT3_uc010jjg.2_Intron|uc010jjh.2_RNA																	0						CCGTTTCCATCGTTCCACCAC	0.602													6	5					0	0	1	0	0
TLX3	30012	broad.mit.edu	37	5	170736421	170736421	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:170736421T>C	uc003mbf.2	+	1	134	c.52T>C	c.(52-54)TTC>CTC	p.F18L	uc003mbe.1_5'Flank	NM_021025	NP_066305	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	18						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCCCATCAGCTTCGGCATCGA	0.781			T	BCL11B	T-ALL								6	7					0	0	1	0	0
DRD1	1812	broad.mit.edu	37	5	174869086	174869086	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:174869086C>T	uc003mcz.2	-	2	1962	c.1017G>A	c.(1015-1017)AAG>AAA	p.K339K		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	339	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	TTGAAAATGCCTTCCGAAAAT	0.448													32	51					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176638265	176638265	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:176638265T>C	uc003mfr.3	+	5	3003	c.2865T>C	c.(2863-2865)GTT>GTC	p.V955V	NSD1_uc003mft.3_Silent_p.V686V|NSD1_uc003mfs.1_Silent_p.V852V|NSD1_uc011dfx.1_Silent_p.V603V	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	955					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCTCTAAGGTTTTGGTTTCAG	0.512			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			11	21					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177697355	177697355	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:177697355C>T	uc003mje.2	-	6	809	c.451G>A	c.(451-453)GGT>AGT	p.G151S	COL23A1_uc010jkt.2_5'UTR	NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	151	Extracellular (Potential).|Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CCATCCAAACCCAGGGGTCCC	0.577													4	15					0	0	1	0	0
AACSL	729522	broad.mit.edu	37	5	178199539	178199539	+	RNA	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:178199539G>A	uc011dgk.1	-	4		c.350C>T			AACSL_uc011dgl.1_RNA|AACSL_uc003mjk.2_RNA	NR_024035				Homo sapiens acetoacetyl-CoA synthetase-like, mRNA (cDNA clone IMAGE:3945810), partial cds.												0						GGCGTGCCCAGAGGCTGTCTT	0.577													13	14					0	0	1	0	0
OR2Y1	134083	broad.mit.edu	37	5	180167054	180167054	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr5:180167054C>T	uc003mmf.1	-	1	5	c.5G>A	c.(4-6)GGA>GAA	p.G2E		NM_001001657	NP_001001657	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTGAAACTTCCCATGGCCTT	0.428													8	11					0	0	1	0	0
CDYL	9425	broad.mit.edu	37	6	4892079	4892079	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:4892079C>T	uc003mwi.2	+	4	450	c.319C>T	c.(319-321)CAC>TAC	p.H107Y	CDYL_uc003mwj.2_Missense_Mutation_p.H53Y|CDYL_uc003mwk.2_Intron|CDYL_uc011dhx.1_5'UTR|CDYL_uc011dhy.1_5'UTR	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	107	Chromo.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		GGAATACATCCACGACTTCAA	0.502													17	42					0	0	1	0	0
FARS2	10667	broad.mit.edu	37	6	5545488	5545488	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:5545488C>T	uc010jnv.1	+	5	1316	c.980C>T	c.(979-981)CCT>CTT	p.P327L	FARS2_uc003mwr.2_Missense_Mutation_p.P327L	NM_006567	NP_006558	O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2 precursor	327					phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	TACGACATCCCTGATATCCGT	0.468													48	126					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584130	7584130	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:7584130G>A	uc003mxp.1	+	24	6914	c.6635G>A	c.(6634-6636)GGA>GAA	p.G2212E	DSP_uc003mxq.1_Missense_Mutation_p.G1613E	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2212	Plectin 6.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TCCTTCCAAGGAATCAGACAA	0.463													22	61					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10928651	10928651	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:10928651C>T	uc003mzo.2	+	18	1752	c.1456C>T	c.(1456-1458)CCG>TCG	p.P486S	SYCP2L_uc011din.1_Intron|SYCP2L_uc010jow.2_Missense_Mutation_p.P106S	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	486						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			gccggtccctccgttcggggt	0.194													12	44					0	0	1	0	0
DCDC2	51473	broad.mit.edu	37	6	24278290	24278290	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:24278290G>A	uc003ndx.2	-	7	1211	c.909C>T	c.(907-909)ACC>ACT	p.T303T	DCDC2_uc003ndy.2_Silent_p.T303T	NM_016356	NP_057440	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	303					cellular defense response|intracellular signal transduction|neuron migration					ovary(1)	1		Ovarian(999;0.101)				TATTTGGAATGGTTTCTTGTG	0.333													4	26					0	0	1	0	0
SCGN	10590	broad.mit.edu	37	6	25689443	25689443	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:25689443G>A	uc003nfb.2	+	8	774	c.571G>A	c.(571-573)GAT>AAT	p.D191N	SCGN_uc010jpz.2_Missense_Mutation_p.D82N	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	191						extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						ATTTAAAATGGATGTAAGTAG	0.368													22	50					0	0	1	0	0
HIST1H4G	8369	broad.mit.edu	37	6	26247008	26247008	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:26247008C>T	uc003nhf.2	-	1	198	c.198G>A	c.(196-198)GTG>GTA	p.V66V		NM_003547	NP_003538	Q99525	H4G_HUMAN	histone cluster 1, H4g	66					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				CGTACCAGATCACATTTTCCA	0.602													16	32					0	0	1	0	0
HIST1H2BI	8346	broad.mit.edu	37	6	26273498	26273498	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:26273498G>C	uc003nhk.2	+	1	295	c.295G>C	c.(295-297)GTG>CTG	p.V99L	HIST1H3G_uc003nhi.2_5'Flank	NM_003525	NP_003516	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	99					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CCAAACGGCTGTGCGCCTGCT	0.592													34	69					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27222581	27222581	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:27222581G>A	uc003nja.2	+	10	1272	c.1260G>A	c.(1258-1260)CAG>CAA	p.Q420Q	PRSS16_uc011dkt.1_RNA|PRSS16_uc003njb.2_Silent_p.Q163Q|PRSS16_uc003njd.2_Intron	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	420					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						CAGTAGCCCAGGCTGTGGCTC	0.547													61	99					0	0	1	0	0
GPX6	257202	broad.mit.edu	37	6	28474150	28474150	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:28474150G>A	uc011dlj.1	-	4	348	c.298C>T	c.(298-300)CCC>TCC	p.P100S	GPX6_uc010jrg.1_RNA	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	100					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	TGGTTGCAGGGAAAGGCCAAC	0.498													22	68					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28540300	28540300	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:28540300C>T	uc003nlo.2	-	4	3984	c.3366G>A	c.(3364-3366)AAG>AAA	p.K1122K		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1122					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						aagttgcattcttcccttgca	0													21	71					0	0	1	0	0
OR2B3	442184	broad.mit.edu	37	6	29054102	29054102	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:29054102G>A	uc003nlx.2	-	1	989	c.924C>T	c.(922-924)ATC>ATT	p.I308I		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						TACAGAAAAAGATTCTTGGCA	0.373													13	35					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141418	29141418	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:29141418G>A	uc011dlm.1	+	1	108	c.6G>A	c.(4-6)ATG>ATA	p.M2I		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GATGAATGATGATTAAAAAAA	0.348													22	87					0	0	1	0	0
OR11A1	26531	broad.mit.edu	37	6	29395394	29395394	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:29395394C>T	uc003nmg.2	-	1	116	c.25G>A	c.(25-27)GAA>AAA	p.E9K		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GTAATAGTTTCGTTTCCTGTG	0.393													9	20					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30131648	30131648	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:30131648G>A	uc010jrx.2	+	1	666	c.187G>A	c.(187-189)GAG>AAG	p.E63K	TRIM10_uc003npn.2_5'Flank|TRIM10_uc003npo.3_5'Flank	NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15	63					mesodermal cell fate determination	intracellular	zinc ion binding				0						CTGCCAAGAGGAGGAGCAGGC	0.642													23	49					0	0	1	0	0
CYP21A2	1589	broad.mit.edu	37	6	32006998	32006998	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:32006998G>A	uc003nze.1	+	3	538	c.420G>A	c.(418-420)GTG>GTA	p.V140V	CYP21A2_uc003nzf.1_Silent_p.V110V	NM_000500	NP_000491	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A,	139					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						AGCCAGTGGTGGAGCAGCTGA	0.647													61	144					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32025933	32025933	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:32025933G>A	uc003nzl.2	-	22	7929	c.7727C>T	c.(7726-7728)ACT>ATT	p.T2576I		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2636	Fibronectin type-III 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GCCCCTCACAGTGACCTTGCT	0.692													106	297					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32035732	32035732	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:32035732C>T	uc003nzl.2	-	18	6452	c.6250G>A	c.(6250-6252)GAA>AAA	p.E2084K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2156					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ATGCTGGGTTCTGTGGGGCTG	0.632													134	339					0	0	1	0	0
PBX2	5089	broad.mit.edu	37	6	32155500	32155500	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:32155500G>A	uc003oav.1	-	5	1065	c.794C>T	c.(793-795)TCC>TTC	p.S265F	PBX2_uc003oaw.2_Missense_Mutation_p.S265F	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	265	Homeobox; TALE-type.						transcription factor binding			ovary(1)	1						ACTCAGGTGGGAGTAGAAATA	0.517													8	438					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32170079	32170080	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:32170079_32170080CC>TT	uc003obb.2	-	21	3667_3668	c.3528_3529GG>AA	c.(3526-3531)AAGGGG>AAAAGG	p.G1177R	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_Intron|NOTCH4_uc011dpv.1_Intron	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1177	LNR 1.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CCCTCACACCCCTTGGCTCCGG	0.663													76	230					0	0	1	0	0
PSMB9	5698	broad.mit.edu	37	6	32827225	32827225	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:32827225C>T	uc003sga.2	+	7	615	c.540C>T	c.(538-540)GTC>GTT	p.V180V		NM_148954	NP_683756	P28065	PSB9_HUMAN	proteasome beta 9 subunit isoform 2 proprotein	192					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0						GCGGGGGTGTCATCTACCTGG	0.512													189	135					0	0	1	0	0
DAXX	1616	broad.mit.edu	37	6	33288188	33288188	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:33288188T>A	uc003oec.2	-	4	1424	c.1220A>T	c.(1219-1221)GAC>GTC	p.D407V	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Missense_Mutation_p.D332V|DAXX_uc011dre.1_Missense_Mutation_p.D419V|DAXX_uc003oed.2_Missense_Mutation_p.D407V|DAXX_uc010juw.2_Missense_Mutation_p.D332V	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	407	Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding	p.D407fs*121(1)		pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						TTCGGGGGTGTCTGCAGAGTG	0.547			Mis|F|N		Pancreatic neuroendocrine tumors								31	92					0	0	1	0	0
DAXX	1616	broad.mit.edu	37	6	33288714	33288714	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:33288714G>A	uc003oec.2	-	3	1042	c.838C>T	c.(838-840)CCT>TCT	p.P280S	ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Missense_Mutation_p.P205S|DAXX_uc011dre.1_Missense_Mutation_p.P292S|DAXX_uc003oed.2_Missense_Mutation_p.P280S|DAXX_uc010juw.2_Missense_Mutation_p.P205S	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	280					activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						AAGGTATCAGGCCCTGGCTTG	0.617			Mis|F|N		Pancreatic neuroendocrine tumors								33	75					0	0	1	0	0
IP6K3	117283	broad.mit.edu	37	6	33693363	33693363	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:33693363T>G	uc010jvf.2	-	6	1156	c.620A>C	c.(619-621)CAG>CCG	p.Q207P	IP6K3_uc003ofb.2_Missense_Mutation_p.Q207P	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	207					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						ATGCGTGTACTGTGACACTAC	0.547													21	46					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34101037	34101037	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:34101037C>T	uc003oir.3	-	1	407	c.237G>A	c.(235-237)CTG>CTA	p.L79L	GRM4_uc011dsn.1_Silent_p.L79L|GRM4_uc010jvh.2_Silent_p.L79L|GRM4_uc010jvi.2_5'UTR|GRM4_uc010jvk.1_5'UTR	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	79	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	GCATGGCCTCCAGCCGGTGGA	0.622													13	36					0	0	1	0	0
TCP11	6954	broad.mit.edu	37	6	35086152	35086152	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:35086152T>C	uc003okd.2	-	10	1626	c.1445A>G	c.(1444-1446)AAC>AGC	p.N482S	TCP11_uc003ojz.1_Missense_Mutation_p.N407S|TCP11_uc003oka.2_Missense_Mutation_p.N407S|TCP11_uc003okb.2_Missense_Mutation_p.N406S|TCP11_uc003okc.2_Missense_Mutation_p.N406S|TCP11_uc011dsu.1_Missense_Mutation_p.N464S|TCP11_uc011dsv.1_Missense_Mutation_p.N431S|TCP11_uc011dsw.1_Missense_Mutation_p.N436S	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	469					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						ATGTGTCAAGTTGACAAACTT	0.483													53	116					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35604866	35604866	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:35604866C>T	uc011dte.1	-	3	378	c.175G>A	c.(175-177)GGA>AGA	p.G59R	FKBP5_uc003okx.2_Missense_Mutation_p.G59R|FKBP5_uc011dtf.1_Intron|FKBP5_uc003oky.2_Missense_Mutation_p.G59R|FKBP5_uc003okz.2_Missense_Mutation_p.G59R	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	59	PPIase FKBP-type 1.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						GACAATTTTCCTTTGTAATGG	0.358													7	38					0	0	1	0	0
C6orf81	221481	broad.mit.edu	37	6	35706282	35706282	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:35706282G>A	uc003ola.2	+	3	539	c.512G>A	c.(511-513)AGG>AAG	p.R171K	LOC285847_uc010jvy.1_5'Flank|C6orf81_uc003olb.1_Missense_Mutation_p.R144K	NM_145028	NP_659465	Q5T9G4	CF081_HUMAN	hypothetical protein LOC221481	144							binding			ovary(1)	1						AGAAAATTCAGGCTCAAAATC	0.463													28	79					0	0	1	0	0
FTSJD2	23070	broad.mit.edu	37	6	37403511	37403511	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:37403511C>T	uc003ons.2	+	2	359	c.106C>T	c.(106-108)CCC>TCC	p.P36S	FTSJD2_uc010jwu.2_Missense_Mutation_p.P36S	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	36					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TGATGAACCTCCCTCCTCTGT	0.512													15	45					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38877314	38877314	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:38877314C>T	uc003ooe.1	+	63	9483	c.8883C>T	c.(8881-8883)GCC>GCT	p.A2961A	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8									p.A2961G(1)		skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGTTCCGTGCCCGTTCTTTGA	0.348													15	75					0	0	1	0	0
GLP1R	2740	broad.mit.edu	37	6	39040784	39040784	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:39040784C>T	uc003ooj.3	+	6	716	c.656C>T	c.(655-657)TCC>TTC	p.S219F	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	219	Extracellular (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	GGGCTCCTCTCCTACCAGGTG	0.617													21	64					0	0	1	0	0
KCNK16	83795	broad.mit.edu	37	6	39284183	39284183	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:39284183G>A	uc003ooq.2	-	5	711	c.697C>T	c.(697-699)CGG>TGG	p.R233W	KCNK17_uc003ooo.2_5'Flank|KCNK17_uc003oop.2_5'Flank|KCNK16_uc003oor.3_Intron|KCNK16_uc010jwy.2_Intron|KCNK16_uc011dtz.1_Missense_Mutation_p.R233W	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	233						integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						GCCAGGCTCCGATACACTGAG	0.607													9	22					0	0	1	0	0
DAAM2	23500	broad.mit.edu	37	6	39856456	39856456	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:39856456T>C	uc003oow.2	+	17	2218	c.2062T>C	c.(2062-2064)TTG>CTG	p.L688L	DAAM2_uc003oox.2_Silent_p.L688L|uc003ooz.1_5'Flank	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	688	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					TTGCCTTAGGTTGAAGCTTTC	0.542													18	36					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40360360	40360360	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:40360360G>A	uc003oph.1	-	3	2157	c.1692C>T	c.(1690-1692)GCC>GCT	p.A564A		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	564	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TCTTGCTGGGGGCCTCGTGGT	0.667													16	34					0	0	1	0	0
FOXP4	116113	broad.mit.edu	37	6	41566642	41566642	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:41566642G>A	uc003oql.2	+	17	2469	c.2011G>A	c.(2011-2013)GAG>AAG	p.E671K	FOXP4_uc003oqm.2_Missense_Mutation_p.E669K|FOXP4_uc003oqn.2_Missense_Mutation_p.E658K	NM_001012426	NP_001012426	Q8IVH2	FOXP4_HUMAN	forkhead box P4 isoform 1	671					embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CAGGGACCTGGAGGAGGAGCT	0.687													11	24					0	0	1	0	0
KIAA0240	23506	broad.mit.edu	37	6	42833144	42833144	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:42833144C>T	uc003osn.1	+	13	3351	c.3200C>T	c.(3199-3201)TCC>TTC	p.S1067F	KIAA0240_uc011duw.1_Missense_Mutation_p.S1067F|KIAA0240_uc003osp.1_Missense_Mutation_p.S1067F	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	1067										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			GAAACTGACTCCATTTTAGAA	0.517													42	116					0	0	1	0	0
RPL7L1	285855	broad.mit.edu	37	6	42852397	42852397	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:42852397C>T	uc003osq.1	+	4	336	c.331C>T	c.(331-333)CGC>TGC	p.R111C	RPL7L1_uc011dux.1_Missense_Mutation_p.R111C|RPL7L1_uc010jxw.1_5'UTR|RPL7L1_uc003osr.1_5'UTR|RPL7L1_uc011duy.1_Missense_Mutation_p.R111C|RPL7L1_uc003oss.1_5'UTR|RPL7L1_uc003ost.2_Missense_Mutation_p.R111C|RPL7L1_uc003osu.2_RNA	NM_198486	NP_940888	Q6DKI1	RL7L_HUMAN	ribosomal protein L7-like 1	111					translation	large ribosomal subunit	protein binding|structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00237)|all cancers(41;0.00288)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.088)			TGCAAGACTTCGCCTAAAGAA	0.443													22	67					0	0	1	0	0
MRPL2	51069	broad.mit.edu	37	6	43023662	43023662	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:43023662G>A	uc003ots.1	-	5	727	c.604C>T	c.(604-606)CGG>TGG	p.R202W	CUL7_uc011dvb.1_5'Flank|CUL7_uc003otq.2_5'Flank|CUL7_uc010jyh.2_5'Flank|KLC4_uc003otr.1_Intron|MRPL2_uc011dvc.1_3'UTR	NM_015950	NP_057034	Q5T653	RM02_HUMAN	mitochondrial ribosomal protein L2 precursor	202					translation	mitochondrion|ribosome	structural constituent of ribosome				0		Ovarian(999;0.0014)	Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00708)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)	BRCA - Breast invasive adenocarcinoma(397;0.0026)		TGGGCACCCCGGCCTGGCTCA	0.552													11	21					0	0	1	0	0
SRF	6722	broad.mit.edu	37	6	43146564	43146564	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:43146564C>T	uc003oui.2	+	6	1850	c.1375C>T	c.(1375-1377)CTG>TTG	p.L459L	SRF_uc011dvf.1_Silent_p.L255L	NM_003131	NP_003122	P11831	SRF_HUMAN	serum response factor (c-fos serum response	459					angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|transcription from RNA polymerase II promoter|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			ovary(1)|breast(1)|central_nervous_system(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CCAGGTGTTCCTGACAGCATC	0.483													120	84					0	0	1	0	0
DLK2	65989	broad.mit.edu	37	6	43418634	43418634	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:43418634C>T	uc003ova.2	-	6	1004	c.795G>A	c.(793-795)GGG>GGA	p.G265G	DLK2_uc003ovb.2_Silent_p.G265G	NM_023932	NP_076421	Q6UY11	DLK2_HUMAN	EGF-like-domain, multiple 9 precursor	265	Extracellular (Potential).					integral to membrane	calcium ion binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CTGAGGTGGGCCCTAGAGGGG	0.642													39	76					0	0	1	0	0
XPO5	57510	broad.mit.edu	37	6	43516013	43516013	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:43516013G>A	uc003ovp.2	-	18	2256	c.2045C>T	c.(2044-2046)TCT>TTT	p.S682F		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	682					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			CATGTCTTGAGAAAGCCAGAT	0.502													60	118					0	0	1	0	0
GTPBP2	54676	broad.mit.edu	37	6	43592649	43592649	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:43592649G>A	uc003ovs.2	-	6	893	c.856C>T	c.(856-858)CTC>TTC	p.L286F	GTPBP2_uc010jyv.2_Missense_Mutation_p.L198F|GTPBP2_uc003ovt.1_Missense_Mutation_p.L286F	NM_019096	NP_061969	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	286							GTP binding|GTPase activity			liver(1)|skin(1)	2	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			GCACTGACGAGGAGCAGGGCG	0.577													27	81					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46656706	46656706	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:46656706G>A	uc003oyj.2	+	1	841	c.841G>A	c.(841-843)GAG>AAG	p.E281K	TDRD6_uc010jze.2_Missense_Mutation_p.E275K	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	281					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CCGCCTCTCCGAGAGCATGGC	0.647													9	17					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46660692	46660692	+	Silent	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:46660692A>G	uc003oyj.2	+	1	4827	c.4827A>G	c.(4825-4827)GAA>GAG	p.E1609E	TDRD6_uc010jze.2_Silent_p.E1603E	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1609	Tudor 7.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GAAACATTGAAGACTGTGTGG	0.418													40	48					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46826469	46826469	+	Silent	SNP	G	A	A	rs151037028		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:46826469G>A	uc003oyo.3	-	17	3460	c.3171C>T	c.(3169-3171)ATC>ATT	p.I1057I	GPR116_uc011dwj.1_Silent_p.I612I|GPR116_uc011dwk.1_Silent_p.I486I|GPR116_uc003oyp.3_Silent_p.I915I|GPR116_uc003oyq.3_Silent_p.I1057I|GPR116_uc010jzi.1_Silent_p.I729I	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	1057	Helical; Name=2; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.I1057I(1)		central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			GGGAGGCAGCGATATTCACTA	0.537													18	35					0	0	1	0	0
GSTA2	2939	broad.mit.edu	37	6	52616499	52616499	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:52616499T>C	uc003pay.2	-	6	572	c.422A>G	c.(421-423)AAG>AGG	p.K141R		NM_000846	NP_000837	P09210	GSTA2_HUMAN	glutathione S-transferase alpha 2	141	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Aminophenazone(DB01424)|Amsacrine(DB00276)|Busulfan(DB01008)|Chlorambucil(DB00291)|Chloroquine(DB00608)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Ethacrynic acid(DB00903)|Glutathione(DB00143)|Mechlorethamine(DB00888)|Praziquantel(DB01058)|Vitamin E(DB00163)	TCCGTGGCTCTTTAAGACCTG	0.542													41	41					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54804701	54804701	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:54804701C>T	uc003pck.2	+	5	1048	c.932C>T	c.(931-933)TCT>TTT	p.S311F		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	311										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					CATTCGGTGTCTTCATTAGCA	0.428													26	32					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55198719	55198719	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:55198719G>A	uc003pcm.1	+	3	379	c.293G>A	c.(292-294)GGA>GAA	p.G98E		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	98	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAACTGCTTGGAAAAAAATGT	0.294													40	57					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62604664	62604664	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:62604664G>A	uc003peg.2	-	6	933	c.686C>T	c.(685-687)ACC>ATC	p.T229I		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	229	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding	p.T229T(1)		skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		CGCTCCACGGGTTACAGTGCT	0.617													19	25					0	0	1	0	0
C6orf221	154288	broad.mit.edu	37	6	74073403	74073403	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:74073403T>C	uc003pgt.3	+	3	527	c.474T>C	c.(472-474)CGT>CGC	p.R158R		NM_001017361	NP_001017361	Q587J8	ECAT1_HUMAN	hypothetical protein LOC154288	158										skin(2)	2						GGACCCAGCGTTCGGTGGAAG	0.672													16	27					0	0	1	0	0
HTR1E	3354	broad.mit.edu	37	6	87725215	87725215	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:87725215C>T	uc003pli.2	+	2	866	c.163C>T	c.(163-165)CAG>TAG	p.Q55*		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	55	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	GAAGCTCCACCAGCCTGCCAA	0.542													32	37					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87971086	87971086	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:87971086C>T	uc003plm.3	+	8	7780	c.7739C>T	c.(7738-7740)TCT>TTT	p.S2580F		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2580					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CATCCTGCATCTTTTGACTGG	0.418													12	19					0	0	1	0	0
MAP3K7	6885	broad.mit.edu	37	6	91228254	91228254	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:91228254C>T	uc003pnz.1	-	16	1714	c.1552G>A	c.(1552-1554)GAA>AAA	p.E518K	MAP3K7_uc003pny.1_Missense_Mutation_p.E55K|MAP3K7_uc003poa.1_Intron|MAP3K7_uc003pob.1_Missense_Mutation_p.E491K|MAP3K7_uc003poc.1_Intron	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	518					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		GCCATAGATTCTTTGGAGTTT	0.318													12	15					0	0	1	0	0
MCHR2	84539	broad.mit.edu	37	6	100395743	100395743	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:100395743C>T	uc003pqh.1	-	3	602	c.287G>A	c.(286-288)GGG>GAG	p.G96E	MCHR2_uc003pqi.1_Missense_Mutation_p.G96E	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	96	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		CCACTCTCCCCCTCGGGCCCA	0.488													45	58					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	100957947	100957947	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:100957947G>A	uc003pqk.2	-	41	6651	c.6322C>T	c.(6322-6324)CCC>TCC	p.P2108S		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	2108	SEC63 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TTTGATTTGGGAAATCGAGGA	0.358													92	93					0	0	1	0	0
QRSL1	55278	broad.mit.edu	37	6	107102704	107102704	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:107102704C>T	uc003prm.2	+	8	1065	c.949C>T	c.(949-951)CTT>TTT	p.L317F		NM_018292	NP_060762	Q9H0R6	QRSL1_HUMAN	glutaminyl-tRNA synthase	317					translation		ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;0.00768)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.248)	Epithelial(6;0.000334)|all cancers(7;0.00157)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0152)	BRCA - Breast invasive adenocarcinoma(108;0.118)|all cancers(137;0.167)|Epithelial(106;0.176)		TGAAGTATCCCTTCCTCACAC	0.423													35	38					0	0	1	0	0
CD164	8763	broad.mit.edu	37	6	109690059	109690059	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:109690059G>A	uc003pte.2	-	6	770	c.589C>T	c.(589-591)CTG>TTG	p.L197L	CD164_uc003ptd.2_Intron|CD164_uc003ptf.2_Silent_p.L178L|CD164_uc011eap.1_Intron|CD164_uc010kdn.2_Silent_p.L184L	NM_006016	NP_006007	Q04900	MUC24_HUMAN	CD164 molecule, sialomucin isoform 1	197	Required for endosomal and lysosomal localization (By similarity).|Cytoplasmic (Potential).				hemopoiesis|heterophilic cell-cell adhesion|immune response|muscle organ development|negative regulation of cell adhesion|negative regulation of cell proliferation|signal transduction	endosome membrane|extracellular region|integral to plasma membrane|lysosomal membrane	protein binding				0		all_cancers(87;4.65e-22)|all_epithelial(87;2.54e-20)|all_lung(197;1.6e-05)|Lung NSC(302;2.92e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.0175)		Epithelial(106;7.83e-46)|all cancers(137;1.15e-45)|OV - Ovarian serous cystadenocarcinoma(136;2.89e-26)|BRCA - Breast invasive adenocarcinoma(108;0.00128)|GBM - Glioblastoma multiforme(226;0.16)		TCTGTTTACAGAGTGTGGTAA	0.378													4	17					0	0	1	0	0
FAM26F	441168	broad.mit.edu	37	6	116784702	116784702	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:116784702C>T	uc003pwv.2	+	3	877	c.782C>T	c.(781-783)TCA>TTA	p.S261L		NM_001010919	NP_001010919	Q5R3K3	FA26F_HUMAN	hypothetical protein LOC441168	261						integral to membrane					0				GBM - Glioblastoma multiforme(226;0.0402)|all cancers(137;0.0627)|OV - Ovarian serous cystadenocarcinoma(136;0.0655)|Epithelial(106;0.231)		CAGCAAATTTCATCACTGTAT	0.393													53	79					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119345394	119345394	+	Nonsense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:119345394A>T	uc003pyj.2	-	2	1092	c.744T>A	c.(742-744)TAT>TAA	p.Y248*	FAM184A_uc003pyk.3_Nonsense_Mutation_p.Y128*|FAM184A_uc003pyl.3_Nonsense_Mutation_p.Y128*	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	248	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						ACTTGCCTTCATAATCCTCAA	0.428													13	21					0	0	1	0	0
GJA1	2697	broad.mit.edu	37	6	121768321	121768321	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:121768321G>A	uc003pyr.2	+	2	578	c.328G>A	c.(328-330)GAG>AAG	p.E110K	GJA1_uc011ebo.1_Missense_Mutation_p.E11K|GJA1_uc011ebp.1_Intron	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	110	Cytoplasmic (Potential).		E -> D (in ODDD).		cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	GAACAAGAAAGAGGAAGAACT	0.438													21	35					0	0	1	0	0
CLVS2	134829	broad.mit.edu	37	6	123369871	123369871	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:123369871G>A	uc003pzi.1	+	4	1538	c.669G>A	c.(667-669)CGG>CGA	p.R223R		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	223	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						AGAAAACTCGGAAAAGGGTAT	0.378													38	61					0	0	1	0	0
NCOA7	135112	broad.mit.edu	37	6	126210952	126210952	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:126210952A>T	uc010kes.2	+	11	2201	c.1752A>T	c.(1750-1752)AAA>AAT	p.K584N	NCOA7_uc003qae.3_Missense_Mutation_p.K584N|NCOA7_uc003qah.2_Missense_Mutation_p.K573N|NCOA7_uc003qai.2_Missense_Mutation_p.K584N|NCOA7_uc010ket.2_Missense_Mutation_p.K469N	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	584					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		CCTGGGTGAAAAAGGGAGAGC	0.468													34	25					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128135060	128135060	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:128135060G>A	uc003qbi.2	-	5	1045	c.726C>T	c.(724-726)ATC>ATT	p.I242I	THEMIS_uc010kfa.2_Silent_p.I145I|THEMIS_uc011ebt.1_Silent_p.I242I|THEMIS_uc010kfb.2_Silent_p.I207I	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	242	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						GGAGGATGCGGATTATATCTT	0.338													27	39					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128326280	128326280	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:128326280C>T	uc003qbk.2	-	15	2807	c.2440G>A	c.(2440-2442)GAA>AAA	p.E814K	PTPRK_uc003qbj.2_Missense_Mutation_p.E815K|PTPRK_uc010kfc.2_Missense_Mutation_p.E815K|PTPRK_uc011ebu.1_Missense_Mutation_p.E815K|PTPRK_uc003qbl.1_Missense_Mutation_p.E709K|PTPRK_uc011ebv.1_Missense_Mutation_p.E825K|PTPRK_uc010kfd.1_Missense_Mutation_p.E28K	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	814	Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		AGAGGATCTTCTGCATGCAGA	0.388													12	17					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128505847	128505847	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:128505847G>A	uc003qbk.2	-	7	1259	c.892C>T	c.(892-894)CCT>TCT	p.P298S	PTPRK_uc003qbj.2_Missense_Mutation_p.P298S|PTPRK_uc010kfc.2_Missense_Mutation_p.P298S|PTPRK_uc011ebu.1_Missense_Mutation_p.P298S|PTPRK_uc003qbl.1_Missense_Mutation_p.P168S|PTPRK_uc011ebv.1_Missense_Mutation_p.P298S	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	298	Fibronectin type-III 1.|Extracellular (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		AGAAGCTGAGGAGGAGCAATG	0.413													25	41					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128540177	128540177	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:128540177G>A	uc003qbk.2	-	6	1125	c.758C>T	c.(757-759)GCT>GTT	p.A253V	PTPRK_uc003qbj.2_Missense_Mutation_p.A253V|PTPRK_uc010kfc.2_Missense_Mutation_p.A253V|PTPRK_uc011ebu.1_Missense_Mutation_p.A253V|PTPRK_uc003qbl.1_Missense_Mutation_p.A123V|PTPRK_uc011ebv.1_Missense_Mutation_p.A253V	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	253	Extracellular (Potential).|Ig-like C2-type.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCTGAAGGAAGCGGCAAACCT	0.413													27	37					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129674431	129674431	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:129674431G>A	uc003qbn.2	+	32	4751	c.4646G>A	c.(4645-4647)CGA>CAA	p.R1549Q	LAMA2_uc003qbo.2_Missense_Mutation_p.R1549Q	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1549	Laminin EGF-like 17.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGCACGTGCCGACCTGGAGCC	0.562													23	40					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131216181	131216181	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:131216181G>A	uc003qch.2	-	9	1497	c.1315C>T	c.(1315-1317)CGT>TGT	p.R439C	EPB41L2_uc003qcg.1_Missense_Mutation_p.R439C|EPB41L2_uc011eby.1_Missense_Mutation_p.R439C|EPB41L2_uc003qci.2_Missense_Mutation_p.R439C|EPB41L2_uc010kfk.2_Missense_Mutation_p.R439C|EPB41L2_uc010kfl.1_Missense_Mutation_p.R439C	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	439	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CAAGCAAAACGATTGATTCGC	0.413													32	39					0	0	1	0	0
VNN2	8875	broad.mit.edu	37	6	133078617	133078617	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:133078617G>A	uc003qdt.2	-	2	293	c.282C>T	c.(280-282)TTC>TTT	p.F94F	VNN2_uc003qds.2_5'UTR|VNN2_uc010kgb.2_Silent_p.F94F|VNN2_uc003qdv.2_Silent_p.F41F	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	94	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CCAGATAAGGGAAAACAGTTT	0.398													19	31					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	137026271	137026271	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:137026271C>T	uc003qhc.2	-	3	950	c.589G>A	c.(589-591)GAA>AAA	p.E197K	MAP3K5_uc011edk.1_Missense_Mutation_p.E42K|MAP3K5_uc010kgw.1_Missense_Mutation_p.E197K	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	197					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		CAAATTATTTCCTGAAAAACA	0.234													9	9					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138192553	138192553	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:138192553C>T	uc003qhr.2	+	2	255	c.189C>T	c.(187-189)ATC>ATT	p.I63I	TNFAIP3_uc003qhs.2_Silent_p.I63I	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	63	TRAF-binding.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		TTCGGGAGATCATCCACAAAG	0.458			D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								23	43					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138584581	138584581	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:138584581G>A	uc003qhu.2	+	12	1961	c.1961G>A	c.(1960-1962)CGA>CAA	p.R654Q		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	654	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CGGTCCCTGCGAACTGCCGCC	0.617													36	56					0	0	1	0	0
FBXO30	84085	broad.mit.edu	37	6	146127185	146127185	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:146127185T>C	uc003qla.2	-	2	556	c.357A>G	c.(355-357)CAA>CAG	p.Q119Q	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	119							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		CCATATCCAATTGTGCCACTT	0.428													38	53					0	0	1	0	0
PPIL4	85313	broad.mit.edu	37	6	149855853	149855853	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:149855853G>A	uc003qmo.1	-	6	552	c.522C>T	c.(520-522)ATC>ATT	p.I174I	PPIL4_uc010kic.2_Intron|PPIL4_uc003qmp.1_Silent_p.I174I	NM_139126	NP_624311	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase-like 4	174					protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		ATCGATCAGGGATTAATAAAT	0.303													26	36					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152646328	152646328	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:152646328C>T	uc010kiw.2	-	81	16150	c.15548G>A	c.(15547-15549)AGG>AAG	p.R5183K	SYNE1_uc003qot.3_Missense_Mutation_p.R5112K|SYNE1_uc003qou.3_Missense_Mutation_p.R5183K|SYNE1_uc010kiz.2_Missense_Mutation_p.R938K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5183	Spectrin 16.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGTCATTGACCTGCTCAGGGT	0.532										HNSCC(10;0.0054)			54	96					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157528033	157528033	+	Nonsense_Mutation	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:157528033G>T	uc003qqn.2	+	20	5856	c.5704G>T	c.(5704-5706)GAG>TAG	p.E1902*	ARID1B_uc003qqo.2_Nonsense_Mutation_p.E1862*|ARID1B_uc003qqp.2_Nonsense_Mutation_p.E1849*	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1907					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CAAGCTGCTGGAGGACGAGCC	0.567													31	54					1.55811e-20	1.58119e-20	1	1	0
ZDHHC14	79683	broad.mit.edu	37	6	158066793	158066793	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:158066793C>T	uc003qqt.2	+	6	1274	c.777C>T	c.(775-777)TTC>TTT	p.F259F	ZDHHC14_uc003qqs.2_Silent_p.F259F|ZDHHC14_uc010kjn.2_5'UTR	NM_024630	NP_078906	Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14 isoform 1	259	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|skin(1)	2		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		TGGTGTGCTTCTTCTCTGTCT	0.552													10	19					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158923027	158923027	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:158923027C>T	uc003qrf.2	+	13	3689	c.2332C>T	c.(2332-2334)CCG>TCG	p.P778S	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	778					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CCTGCCTCCCCCGCCGCAGGG	0.637													42	41					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159166549	159166549	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:159166549T>G	uc003qrp.2	+	11	1137	c.893T>G	c.(892-894)ATG>AGG	p.M298R	SYTL3_uc011efp.1_Missense_Mutation_p.M298R|SYTL3_uc003qro.2_Missense_Mutation_p.M230R|SYTL3_uc003qrq.2_Missense_Mutation_p.M230R|SYTL3_uc003qrr.2_Missense_Mutation_p.M298R|SYTL3_uc003qrs.2_Missense_Mutation_p.M230R|SYTL3_uc011efq.1_Missense_Mutation_p.M24R	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	298					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TGTACAGAGATGGGCAATTTT	0.338													11	13					0	0	1	0	0
EZR	7430	broad.mit.edu	37	6	159206568	159206568	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:159206568G>A	uc003qrt.3	-	4	455	c.240C>T	c.(238-240)TTC>TTT	p.F80F	EZR_uc011efs.1_Silent_p.F48F|EZR_uc003qru.3_Silent_p.F80F	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	80	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		ACTTGGCCCGGAACTTGAACT	0.532													20	29					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160484639	160484639	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:160484639C>T	uc003qta.2	+	27	4011	c.3863C>T	c.(3862-3864)CCG>CTG	p.P1288L		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1288	9.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		AAGCGGGAACCGCAGGGATTT	0.428													20	29					0	0	1	0	0
SLC22A2	6582	broad.mit.edu	37	6	160679627	160679627	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:160679627C>T	uc003qtf.2	-	1	333	c.163G>A	c.(163-165)GGA>AGA	p.G55R	SLC22A2_uc003qte.1_Missense_Mutation_p.G55R|SLC22A2_uc003qth.1_Missense_Mutation_p.G55R	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	55	Extracellular (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		TCGGCCACTCCGGGGCTCCGG	0.647													29	31					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161006150	161006150	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:161006150C>T	uc003qtl.2	-	27	4337	c.4217G>A	c.(4216-4218)GGA>GAA	p.G1406E		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3914	Kringle 35.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ACATGTTCTTCCTGTGATAGT	0.463													51	72					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161021955	161021955	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:161021955C>T	uc003qtl.2	-	20	3241	c.3121G>A	c.(3121-3123)GAA>AAA	p.E1041K		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3549	Kringle 31.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TTACCTTGTTCAAAAAAAGCC	0.507													15	24					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161027681	161027681	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:161027681G>A	uc003qtl.2	-	18	2733	c.2613C>T	c.(2611-2613)ATC>ATT	p.I871I		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3379	Kringle 30.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AGTAGTTCATGATCAAGCCAC	0.507													53	90					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161071470	161071470	+	Nonsense_Mutation	SNP	G	A	A	rs121912503		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:161071470G>A	uc003qtl.2	-	3	229	c.109C>T	c.(109-111)CGA>TGA	p.R37*		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	2545	Kringle 23.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TACGTGCCTCGATAACTCTGT	0.453													63	84					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161174018	161174018	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:161174018C>T	uc003qtm.3	+	19	2421	c.2358C>T	c.(2356-2358)CGC>CGT	p.R786R		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	786	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GCTGTGCACGCCCCAATAAGC	0.473													10	18					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162394441	162394441	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:162394441G>A	uc003qtx.3	-	6	761	c.627C>T	c.(625-627)TTC>TTT	p.F209F	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Silent_p.F18F|PARK2_uc003qtw.3_Silent_p.F18F|PARK2_uc003qty.3_Silent_p.F181F|PARK2_uc003qtz.3_Silent_p.F60F|PARK2_uc010kke.1_Silent_p.F209F	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	209	SYT11 binding 1.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CACATTTAAAGAAAAATTCCT	0.413													13	19					0	0	1	0	0
KIF25	3834	broad.mit.edu	37	6	168434624	168434624	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr6:168434624G>A	uc003qwk.1	+	4	492	c.230G>A	c.(229-231)GGA>GAA	p.G77E	KIF25_uc003qwl.1_Missense_Mutation_p.G77E	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	77	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		ACCATGCTGGGACGCCATTCG	0.522													18	29					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	803543	803543	+	Missense_Mutation	SNP	C	T	T	rs147690117		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:803543C>T	uc010krz.1	+	8	1735	c.1715C>T	c.(1714-1716)GCG>GTG	p.A572V	HEATR2_uc003siz.2_Missense_Mutation_p.A440V|HEATR2_uc003sja.2_Missense_Mutation_p.A30V	NM_017802	NP_060272	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	572							protein binding			skin(1)	1		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		CGGGTGACCGCGTCGCACCTT	0.652													23	768					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	943807	943807	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:943807C>T	uc003sjo.3	-	6	780	c.604G>A	c.(604-606)GAC>AAC	p.D202N	ADAP1_uc003sjm.3_Missense_Mutation_p.D28N|ADAP1_uc011jvs.1_Missense_Mutation_p.D107N|ADAP1_uc003sjn.3_Missense_Mutation_p.D130N|ADAP1_uc010ksc.2_Missense_Mutation_p.D130N	NM_006869	NP_006860	O75689	ADAP1_HUMAN	centaurin, alpha 1	202	PH 1.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			upper_aerodigestive_tract(1)	1						GTGCTGTTGTCCTTCAGGTAG	0.647													523	37					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2740300	2740300	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:2740300A>G	uc003smr.1	+	2	576	c.215A>G	c.(214-216)GAG>GGG	p.E72G	AMZ1_uc003sms.1_Missense_Mutation_p.E72G|AMZ1_uc011jwa.1_5'Flank	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	72							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		AGCCGACCCGAGGCTCCCGAG	0.672													26	319					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11676579	11676579	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:11676579C>T	uc003ssf.3	-	2	452	c.200G>A	c.(199-201)GGC>GAC	p.G67D		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	67	TSP type-1 1.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CATACATCGGCCCCATGGACC	0.448										HNSCC(18;0.044)			22	69					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28547243	28547243	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:28547243C>T	uc003szq.2	+	4	569	c.179C>T	c.(178-180)CCG>CTG	p.P60L	CREB5_uc003szo.2_Missense_Mutation_p.P27L|CREB5_uc003szr.2_Missense_Mutation_p.P53L	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	60					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GATCAAACTCCGACCCCAACG	0.522													270	182					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31614327	31614327	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:31614327G>A	uc003tcj.1	+	7	1562	c.569G>A	c.(568-570)CGA>CAA	p.R190Q	CCDC129_uc011kad.1_Missense_Mutation_p.R200Q|CCDC129_uc003tci.1_Missense_Mutation_p.R189Q|CCDC129_uc011kae.1_Missense_Mutation_p.R216Q|CCDC129_uc003tck.1_Missense_Mutation_p.R98Q	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	190											0						CAAAAGCAGCGAATGGACATT	0.498													13	30					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	32091189	32091189	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:32091189C>T	uc003tcm.1	-	2	574	c.105G>A	c.(103-105)AGG>AGA	p.R35R	PDE1C_uc003tcn.1_Silent_p.R35R|PDE1C_uc003tco.1_Intron|PDE1C_uc003tcr.2_Silent_p.R35R|PDE1C_uc003tcs.2_Silent_p.R35R	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	35					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TCTTATATTTCCTCCTGTAAG	0.468													7	18					0	0	1	0	0
FKBP9	11328	broad.mit.edu	37	7	33014864	33014864	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:33014864C>T	uc003tdh.2	+	3	619	c.438C>T	c.(436-438)GAC>GAT	p.D146D	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Silent_p.D199D|FKBP9_uc003tdg.2_Silent_p.D146D|FKBP9_uc010kwm.2_Silent_p.D53D	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	146					protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			ATTCTGAAGACCAGGTTCAGA	0.463													25	33					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34192749	34192749	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:34192749G>A	uc011kap.1	+	15	2036	c.1922G>A	c.(1921-1923)GGA>GAA	p.G641E		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	641	TIL.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						TGTGGTCCGGGATGTATCAAG	0.498													53	71					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34724175	34724175	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:34724175G>A	uc003teg.1	+	2	287	c.159G>A	c.(157-159)TTG>TTA	p.L53L	AAA1_uc010kwo.1_Intron|AAA1_uc010kwp.1_Intron|AAA1_uc003tdz.2_Intron|AAA1_uc010kwq.1_Intron|AAA1_uc003teb.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Silent_p.L53L|NPSR1_uc010kwt.1_5'UTR|NPSR1_uc010kwu.1_5'UTR|NPSR1_uc010kwv.1_Silent_p.L53L|NPSR1_uc003tei.1_Silent_p.L53L|NPSR1_uc010kww.1_Silent_p.L53L|NPSR1_uc011kar.1_Silent_p.L53L	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	53	Helical; Name=1; (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	CTGAGCAATTGATAACTCTGT	0.423													28	45					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35130022	35130022	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:35130022C>T	uc003teq.1	-	21	2270	c.1163G>A	c.(1162-1164)CGA>CAA	p.R388Q	DPY19L2P1_uc003tep.1_RNA|DPY19L2P1_uc010kwz.1_RNA					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						GGCAGATTTTCGACTATATGT	0.274													23	47					0	0	1	0	0
EEPD1	80820	broad.mit.edu	37	7	36324392	36324392	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:36324392A>C	uc003tfa.2	+	5	1779	c.1139A>C	c.(1138-1140)AAG>ACG	p.K380T		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	380					DNA repair		DNA binding				0						GGGCACGGGAAGCTGGCGGGC	0.612													39	43					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36570032	36570032	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:36570032A>C	uc003tfh.3	-	19	1915	c.1514T>G	c.(1513-1515)TTC>TGC	p.F505C	AOAH_uc010kxf.2_Missense_Mutation_p.F505C|AOAH_uc011kba.1_Missense_Mutation_p.F473C	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	505					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						ACTTTCATGGAAGGCAAAATC	0.403													12	24					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43484277	43484277	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:43484277G>A	uc003tid.1	+	11	2111	c.1506G>A	c.(1504-1506)GAG>GAA	p.E502E	HECW1_uc011kbi.1_Silent_p.E502E	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	502	Glu-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						Gggaagaagaggagaaggagc	0.537													6	6					0	0	1	0	0
CAMK2B	816	broad.mit.edu	37	7	44259723	44259723	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:44259723C>T	uc003tkq.2	-	23	2149	c.1939G>A	c.(1939-1941)GAC>AAC	p.D647N	CAMK2B_uc003tkp.2_Missense_Mutation_p.D523N|CAMK2B_uc003tkx.2_Missense_Mutation_p.D483N|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.D499N|CAMK2B_uc003tks.2_Missense_Mutation_p.D498N|CAMK2B_uc003tku.2_Missense_Mutation_p.D484N|CAMK2B_uc003tkv.2_Missense_Mutation_p.D460N|CAMK2B_uc003tkt.2_Missense_Mutation_p.D473N|CAMK2B_uc003tkw.2_Missense_Mutation_p.D430N|CAMK2B_uc010kyc.2_Missense_Mutation_p.D523N|CAMK2B_uc003tkn.2_Missense_Mutation_p.D280N	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	647					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						CACTTGCCGTCGCGGCGGTGC	0.667													6	8					0	0	1	0	0
TMED4	222068	broad.mit.edu	37	7	44619144	44619144	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:44619144G>A	uc003tli.2	-	5	640	c.618C>T	c.(616-618)CTC>CTT	p.L206L	uc003tll.2_5'Flank	NM_182547	NP_872353	Q7Z7H5	TMED4_HUMAN	transmembrane emp24 protein transport domain	206	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade|transport	endoplasmic reticulum membrane|integral to membrane	signal transducer activity				0						CAGTGAGGATGAGGATGACAG	0.532													29	40					0	0	1	0	0
IGFBP3	3486	broad.mit.edu	37	7	45957021	45957021	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:45957021C>T	uc003tns.2	-	2	553	c.421G>A	c.(421-423)GAG>AAG	p.E141K	IGFBP3_uc003tnq.2_RNA|IGFBP3_uc003tnr.2_Missense_Mutation_p.E147K|IGFBP3_uc003tnt.2_Missense_Mutation_p.E44K	NM_000598	NP_000589	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	141	Ser/Thr-rich.				negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(2)|lung(1)	3					Mecasermin(DB01277)	CGGTCTTCCTCCGACTCACTA	0.498											OREG0018049	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	20					0	0	1	0	0
SUN3	256979	broad.mit.edu	37	7	48068433	48068433	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:48068433C>T	uc003tof.2	-	2	200	c.103G>A	c.(103-105)GAA>AAA	p.E35K	SUN3_uc003tog.2_Missense_Mutation_p.E35K|SUN3_uc011kcf.1_5'UTR	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	35						integral to membrane				central_nervous_system(1)	1						TCAGGATTTTCGTCCTCTGAT	0.458													21	43					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50605574	50605574	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:50605574C>T	uc003tpf.3	-	4	505	c.419G>A	c.(418-420)GGG>GAG	p.G140E	DDC_uc010kza.2_Intron|DDC_uc003tpg.3_Missense_Mutation_p.G140E	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	140	2.|2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CACTCCTCCCCCTTCTCCAGC	0.557													26	44					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57528441	57528441	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:57528441C>T	uc011kdi.1	+	4	386	c.274C>T	c.(274-276)CAT>TAT	p.H92Y		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						TACATGTTCTCATTTCACCCA	0.323													16	25					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	70800611	70800611	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:70800611C>T	uc003tvy.2	+	2	314	c.314C>T	c.(313-315)CCG>CTG	p.P105L	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	105	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				ACTCTTTCCCCGGCTGAAGAA	0.473													30	42					0	0	1	0	0
LAT2	7462	broad.mit.edu	37	7	73634321	73634321	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:73634321G>A	uc003uag.2	+	6	760	c.210G>A	c.(208-210)GCG>GCA	p.A70A	RFC2_uc011kfa.1_Intron|LAT2_uc003uah.2_Silent_p.A70A|LAT2_uc003uai.2_Silent_p.A70A|LAT2_uc010lbo.2_RNA	NM_032464	NP_115853	Q9GZY6	NTAL_HUMAN	linker for activation of T cells family member	70	Cytoplasmic (Potential).				B cell activation|B cell receptor signaling pathway|calcium-mediated signaling|mast cell degranulation	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding				0						GACCCCTGGCGGACATGGCAC	0.632													20	17					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90896122	90896122	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:90896122G>A	uc003ula.2	+	1	2340	c.1927G>A	c.(1927-1929)GGG>AGG	p.G643R		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	643	Cytoplasmic (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CAGCAAACAAGGGGAGACTAC	0.637													16	34					0	0	1	0	0
PEG10	23089	broad.mit.edu	37	7	94293127	94293127	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:94293127G>A	uc011kie.1	+	2	704	c.487G>A	c.(487-489)GAT>AAT	p.D163N		NM_001040152	NP_001035242	Q86TG7	PEG10_HUMAN	paternally expressed 10 isoform RF1	87	Necessary for interaction with ALK1.				apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AGAGAAGTTCGATGGCAACCC	0.562													18	17					0	0	1	0	0
CYP3A4	1576	broad.mit.edu	37	7	99364064	99364064	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:99364064G>A	uc003urv.1	-	9	905	c.801C>T	c.(799-801)CAC>CAT	p.H267H	CYP3A4_uc003urw.1_Silent_p.H266H|CYP3A4_uc011kiz.1_Silent_p.H226H|CYP3A4_uc011kja.1_Silent_p.H218H|CYP3A4_uc011kjb.1_Silent_p.H117H	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	267					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	AATCCACTCGGTGCTAGAAGC	0.448													20	26					0	0	1	0	0
GPC2	221914	broad.mit.edu	37	7	99771509	99771509	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:99771509G>A	uc003utv.2	-	5	1009	c.841C>T	c.(841-843)CGT>TGT	p.R281C	GPC2_uc010lgr.2_Intron|GPC2_uc003utw.1_3'UTR	NM_152742	NP_689955	Q8N158	GPC2_HUMAN	glypican 2 precursor	281						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|pancreas(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGACAGCCACGAACCACGTTG	0.547													90	128					0	0	1	0	0
STAG3	10734	broad.mit.edu	37	7	99798497	99798497	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:99798497G>A	uc003utx.1	+	19	2121	c.1966G>A	c.(1966-1968)GAA>AAA	p.E656K	STAG3_uc010lgs.1_Missense_Mutation_p.E444K|STAG3_uc011kjk.1_Missense_Mutation_p.E598K|GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc003uua.3_3'UTR|GATS_uc010lgt.2_RNA|STAG3_uc003uub.1_5'UTR	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	656					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGTAATCCCGAATTCACTTT	0.582													31	42					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100373159	100373159	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:100373159G>A	uc003uwj.2	+	33	6154	c.5989G>A	c.(5989-5991)GAT>AAT	p.D1997N	ZAN_uc003uwk.2_Missense_Mutation_p.D1997N|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Missense_Mutation_p.D84N	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1997	Extracellular (Potential).|VWFD 3.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGACATCTACGATGCCCAGGT	0.597													14	14					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100403258	100403258	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:100403258G>T	uc003uwn.1	-	15	3034	c.2543C>A	c.(2542-2544)TCC>TAC	p.S848Y	EPHB4_uc003uwm.1_Missense_Mutation_p.S755Y|EPHB4_uc010lhj.1_Missense_Mutation_p.S848Y	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	848	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					CTGGTGGAGGGAGGTGGGACA	0.627													56	70					9.04393e-38	9.21687e-38	1	1	0
EPHB4	2050	broad.mit.edu	37	7	100405170	100405170	+	Silent	SNP	G	A	A	rs112613465		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:100405170G>A	uc003uwn.1	-	13	2642	c.2151C>T	c.(2149-2151)CTC>CTT	p.L717L	EPHB4_uc003uwm.1_Silent_p.L624L|EPHB4_uc010lhj.1_Silent_p.L717L	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	717	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GCATGCCCACGAGCTGGATGA	0.612													22	29					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678637	100678637	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:100678637G>A	uc003uxp.1	+	3	3993	c.3940G>A	c.(3940-3942)GAA>AAA	p.E1314K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1314	Extracellular (Potential).|20.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACTTCTAATGAAGTCAGTTC	0.463													69	119					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100684128	100684128	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:100684128C>T	uc003uxp.1	+	3	9484	c.9431C>T	c.(9430-9432)TCA>TTA	p.S3144L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3144	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|51.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGCCCATTCATCTCCTACA	0.498													115	181					0	0	1	0	0
DPY19L2P2	349152	broad.mit.edu	37	7	102878237	102878237	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:102878237G>A	uc003vbh.3	-	12	2640	c.449C>T	c.(448-450)CCC>CTC	p.P150L	DPY19L2P2_uc003vbg.3_RNA|DPY19L2P2_uc010lit.2_RNA	NR_003561				RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						AAATTGCCAGGGAAGCATAAA	0.279													13	19					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103629630	103629630	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:103629630G>A	uc003vca.2	-	1	334	c.174C>T	c.(172-174)TCC>TCT	p.S58S	RELN_uc010liz.2_Silent_p.S58S	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	58	Reelin.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAATATGCAGGGAAATGAGCA	0.652													17	43					0	0	1	0	0
MDFIC	29969	broad.mit.edu	37	7	114619749	114619749	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:114619749C>T	uc003vhf.2	+	4	996	c.733C>T	c.(733-735)CAG>TAG	p.Q245*		NM_199072	NP_951038	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing protein	136					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleolus|nucleolus|nucleus	cyclin binding|Tat protein binding			ovary(1)	1						TAGAAAAATTCAGTCCAGCTT	0.418													18	39					0	0	1	0	0
ANKRD7	56311	broad.mit.edu	37	7	117864914	117864914	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:117864914G>A	uc003vji.2	+	1	203	c.30G>A	c.(28-30)AGG>AGA	p.R10R		NM_019644	NP_062618	Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	10					male gonad development						0						TCTGGAAGAGGAAGAATGAGA	0.512													19	35					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	120387737	120387737	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:120387737G>A	uc003vjj.1	+	6	2683	c.1718G>A	c.(1717-1719)CGA>CAA	p.R573Q		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	573	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					TCTATCAGCCGATCCAGTTTA	0.303													12	14					0	0	1	0	0
ING3	54556	broad.mit.edu	37	7	120590960	120590960	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:120590960C>T	uc003vjn.2	+	1	144	c.10C>T	c.(10-12)CTA>TTA	p.L4L	ING3_uc011knr.1_Silent_p.L4L|ING3_uc003vjl.2_Silent_p.L4L|ING3_uc003vjm.1_Silent_p.L4L|ING3_uc003vjo.2_5'UTR|ING3_uc003vjp.2_Silent_p.L4L|ING3_uc011kns.1_5'Flank	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	4					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					GATGTTGTACCTAGAAGACTA	0.453													28	47					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122033335	122033335	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:122033335G>A	uc010lkp.2	-	21	3086	c.2923C>T	c.(2923-2925)CCA>TCA	p.P975S	CADPS2_uc011knx.1_Missense_Mutation_p.P350S|CADPS2_uc003vkg.3_Intron|CADPS2_uc010lkq.2_Intron	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	975	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						GGAACTTTTGGAAGAGCTACA	0.438													23	24					0	0	1	0	0
ASB15	142685	broad.mit.edu	37	7	123264794	123264794	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:123264794G>A	uc003vku.1	+	8	915	c.623G>A	c.(622-624)GGA>GAA	p.G208E	ASB15_uc003vkv.1_Missense_Mutation_p.G208E|ASB15_uc003vkw.1_Missense_Mutation_p.G208E	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	208	ANK 3.				intracellular signal transduction					skin(2)|lung(1)	3						CTGAGAGATGGATTTGGAGTC	0.488											OREG0018282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	21					0	0	1	0	0
WASL	8976	broad.mit.edu	37	7	123346839	123346839	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:123346839A>C	uc003vkz.2	-	3	622	c.294T>G	c.(292-294)TTT>TTG	p.F98L		NM_003941	NP_003932	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome gene-like protein	98	WH1.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity				0						TATTATATACAAAGTTATTGT	0.289													17	28					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129962508	129962508	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:129962508C>T	uc003vpr.2	+	11	1305	c.1258C>T	c.(1258-1260)CTC>TTC	p.L420F	CPA4_uc011kpd.1_Missense_Mutation_p.L387F|CPA4_uc011kpe.1_Missense_Mutation_p.L316F	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	420					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					GCGGGACAACCTCTACTAGGC	0.547													36	50					0	0	1	0	0
FAM180A	389558	broad.mit.edu	37	7	135418800	135418800	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:135418800C>T	uc003vtd.2	-	3	711	c.445G>A	c.(445-447)GCG>ACG	p.A149T	FAM180A_uc010lmt.2_RNA|FAM180A_uc010lmu.2_Missense_Mutation_p.A149T	NM_205855	NP_995327	Q6UWF9	F180A_HUMAN	hypothetical protein LOC389558 precursor	149						extracellular region				ovary(2)	2						AGGGACTGCGCCCAGATGTCC	0.602													23	19					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138764314	138764314	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:138764314G>A	uc003vun.2	-	4	1761	c.1373C>T	c.(1372-1374)TCA>TTA	p.S458L	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Missense_Mutation_p.S458L	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	458					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						CCTAGGTGATGATATTTCTCT	0.463													25	44					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139724587	139724587	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:139724587A>G	uc003vvl.1	-	12	2753	c.1879T>C	c.(1879-1881)TTC>CTC	p.F627L	PARP12_uc003vvk.1_Missense_Mutation_p.F413L|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	627	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					CCCCTGACGAACTCGCCCACC	0.602													16	39					0	0	1	0	0
JHDM1D	80853	broad.mit.edu	37	7	139818971	139818971	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:139818971G>A	uc003vvm.2	-	9	1192	c.1188C>T	c.(1186-1188)TTC>TTT	p.F396F	JHDM1D_uc010lng.2_RNA	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	396					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					CAAAGAAAGGGAATTTGAAAA	0.294													43	65					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140301428	140301428	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:140301428G>A	uc010lnj.2	-	1	915	c.770C>T	c.(769-771)TCC>TTC	p.S257F	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.S257F|DENND2A_uc003vvw.2_Missense_Mutation_p.S257F|DENND2A_uc003vvx.2_Missense_Mutation_p.S257F	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	257										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					CTTTGTGGGGGAACCCTCCGA	0.597													68	112					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141752674	141752674	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:141752674G>A	uc003vwy.2	+	26	3103	c.3049G>A	c.(3049-3051)GCT>ACT	p.A1017T		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1017	Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TGGGGCCACAGCTGACATCTC	0.458													53	56					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144097322	144097322	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:144097322C>A	uc011kue.1	-	5	928	c.928G>T	c.(928-930)GGG>TGG	p.G310W		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	310	Homeobox.				cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					GGGGTCACCCCCACCGTCTGG	0.552													27	38					9.80776e-20	9.94599e-20	1	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146741005	146741005	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:146741005C>T	uc003weu.1	+	4	925	c.409C>T	c.(409-411)CCC>TCC	p.P137S		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	137	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCAGGCATTTCCCGGAAACAT	0.408										HNSCC(39;0.1)			24	34					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269450	150269450	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:150269450G>A	uc003whl.2	+	3	374	c.292G>A	c.(292-294)GAA>AAA	p.E98K	GIMAP4_uc011kuu.1_Intron|GIMAP4_uc011kuv.1_Missense_Mutation_p.E112K	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	98							GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCCAATGCTGAAACGTCCAA	0.512													23	31					0	0	1	0	0
PRKAG2	51422	broad.mit.edu	37	7	151265878	151265878	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:151265878G>A	uc003wkk.2	-	11	1768	c.1157C>T	c.(1156-1158)CCC>CTC	p.P386L	PRKAG2_uc003wki.2_Missense_Mutation_p.P145L|PRKAG2_uc011kvl.1_Missense_Mutation_p.P261L|PRKAG2_uc003wkj.2_Missense_Mutation_p.P342L|PRKAG2_uc003wkl.2_Intron|PRKAG2_uc010lqe.1_RNA	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	386	CBS 2.				ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		GTCAATAACGGGCAATCTGTG	0.383													4	20					0	0	1	0	0
MLL3	58508	broad.mit.edu	37	7	151970799	151970799	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:151970799G>A	uc003wla.2	-	7	1222	c.1003C>T	c.(1003-1005)CCT>TCT	p.P335S		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	335					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CATCTTTCAGGAGCTTGGTCA	0.383			N		medulloblastoma								6	191					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154876071	154876071	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:154876071C>T	uc003wlu.1	+	2	1012	c.948C>T	c.(946-948)CCC>CCT	p.P316P		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	316	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GTGACATCCCCGCCATCTGGA	0.542													52	70					0	0	1	0	0
LMBR1	64327	broad.mit.edu	37	7	156589167	156589168	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:156589167_156589168GG>AA	uc003wmw.3	-	5	553_554	c.338_339CC>TT	c.(337-339)TCC>TTT	p.S113F	LMBR1_uc003wmv.3_5'UTR|LMBR1_uc003wmx.3_5'UTR|LMBR1_uc010lqn.2_Missense_Mutation_p.S113F|LMBR1_uc011kvx.1_Missense_Mutation_p.S92F	NM_022458	NP_071903	Q8WVP7	LMBR1_HUMAN	limb region 1 protein	113	Helical; (Potential).					integral to membrane	receptor activity				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		TGGAAAAAAGGGAAGCAAGATT	0.327													5	9					0	0	1	0	0
NCAPG2	54892	broad.mit.edu	37	7	158456922	158456922	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr7:158456922G>A	uc003wnv.1	-	15	1914	c.1769C>T	c.(1768-1770)CCA>CTA	p.P590L	NCAPG2_uc010lqu.1_Missense_Mutation_p.P382L|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Missense_Mutation_p.P590L|NCAPG2_uc011kwe.1_Missense_Mutation_p.P590L|NCAPG2_uc011kwc.1_Missense_Mutation_p.P91L|NCAPG2_uc011kwd.1_Missense_Mutation_p.P91L	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	590					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		CTCGTCCTCTGGAGGCTCTCT	0.493													43	48					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3000172	3000172	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:3000172A>T	uc011kwk.1	-	41	6449	c.6059T>A	c.(6058-6060)TTT>TAT	p.F2020Y	CSMD1_uc011kwj.1_Missense_Mutation_p.F1412Y|CSMD1_uc010lrg.2_Missense_Mutation_p.F88Y	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2020	Extracellular (Potential).|CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTCGGTAGAAAAATTCAGAAA	0.393													52	64					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3205548	3205548	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:3205548C>T	uc011kwk.1	-	22	3833	c.3443G>A	c.(3442-3444)CGA>CAA	p.R1148Q	CSMD1_uc011kwj.1_Missense_Mutation_p.R540Q|CSMD1_uc003wqe.2_Missense_Mutation_p.R304Q	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1148	Extracellular (Potential).|CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTGGAAGCTTCGTGTTCTAAG	0.353													7	5					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3216833	3216833	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:3216833C>T	uc011kwk.1	-	21	3538	c.3148G>A	c.(3148-3150)GGA>AGA	p.G1050R	CSMD1_uc011kwj.1_Missense_Mutation_p.G442R|CSMD1_uc003wqe.2_Missense_Mutation_p.G206R	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1050	Sushi 6.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCAGGGACTCCAGGATCATCA	0.448													16	21					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3253834	3253834	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:3253834G>A	uc011kwk.1	-	17	2868	c.2478C>T	c.(2476-2478)ATC>ATT	p.I826I	CSMD1_uc011kwj.1_Silent_p.I218I|CSMD1_uc003wqe.2_5'UTR	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	826	Extracellular (Potential).|CUB 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGTACTCGCCGATCAGTGGGG	0.537													3	7					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10466767	10466767	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:10466767C>T	uc003wtc.2	-	4	5070	c.4841G>A	c.(4840-4842)CGA>CAA	p.R1614Q		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1614					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CGAGAGGTTTCGCAGGCCCCG	0.711													9	16					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14412356	14412356	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:14412356C>T	uc003wwq.2	-	2	779	c.119G>A	c.(118-120)GGA>GAA	p.G40E	SGCZ_uc010lss.2_Missense_Mutation_p.G27E	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	27	Cytoplasmic (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		TCCATAAATTCCCACTGGGTA	0.368													49	67					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16025993	16025993	+	Nonsense_Mutation	SNP	G	A	A	rs148631001		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:16025993G>A	uc003wwz.2	-	4	802	c.604C>T	c.(604-606)CAA>TAA	p.Q202*	MSR1_uc010lsu.2_Nonsense_Mutation_p.Q220*|MSR1_uc003wxa.2_Nonsense_Mutation_p.Q202*|MSR1_uc003wxb.2_Nonsense_Mutation_p.Q202*|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	202	Potential.|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		GTATTCTCTTGGATTTTGCCA	0.403													11	31					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16026286	16026286	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:16026286C>T	uc003wwz.2	-	4	509	c.311G>A	c.(310-312)AGC>AAC	p.S104N	MSR1_uc010lsu.2_Missense_Mutation_p.S122N|MSR1_uc003wxa.2_Missense_Mutation_p.S104N|MSR1_uc003wxb.2_Missense_Mutation_p.S104N|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	104	Spacer (Probable).|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TTCCTCTTCGCTGTCATTTCC	0.398													42	56					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16035485	16035485	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:16035485C>T	uc003wwz.2	-	2	211	c.13G>A	c.(13-15)GAT>AAT	p.D5N	MSR1_uc010lsu.2_Missense_Mutation_p.D23N|MSR1_uc003wxa.2_Missense_Mutation_p.D5N|MSR1_uc003wxb.2_Missense_Mutation_p.D5N|MSR1_uc011kxz.1_5'UTR	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	5	Cytoplasmic (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TGAAAGTGATCCCACTGCTCC	0.388													10	20					0	0	1	0	0
PDGFRL	5157	broad.mit.edu	37	8	17491611	17491611	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:17491611C>T	uc003wxr.2	+	5	889	c.828C>T	c.(826-828)ATC>ATT	p.I276I		NM_006207	NP_006198	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	276	Ig-like C2-type 2.					extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity				0				Colorectal(111;0.0752)		CAACAACCATCTTGGCTTCTT	0.527													86	102					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18413814	18413814	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:18413814C>T	uc003wza.2	-	15	2936	c.2833G>A	c.(2833-2835)GAG>AAG	p.E945K	PSD3_uc003wyx.3_Missense_Mutation_p.E274K|PSD3_uc003wyy.2_Missense_Mutation_p.E411K|PSD3_uc003wyz.2_Missense_Mutation_p.E246K	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	946	Potential.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TCGGCCAGCTCGGTGGTGATC	0.468													39	55					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18730175	18730175	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:18730175C>T	uc003wza.2	-	3	302	c.199G>A	c.(199-201)GAG>AAG	p.E67K		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	67					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CCACCTTCCTCCATGGTCCCA	0.498													26	42					0	0	1	0	0
Unknown	0	broad.mit.edu	37	8	22938818	22938818	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:22938818C>T	uc003xcw.1	+	3		c.322C>T								Homo sapiens cDNA FLJ14233 fis, clone NT2RP4000049.																		GGAAATAATTCAGGACCAACT	0.473													6	3					0	0	1	0	0
ADRA1A	148	broad.mit.edu	37	8	26627906	26627906	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:26627906C>T	uc003xfh.1	-	2	1597	c.1161G>A	c.(1159-1161)AGG>AGA	p.R387R	ADRA1A_uc003xfc.1_Silent_p.R387R|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Silent_p.R387R|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron|ADRA1A_uc003xfg.1_Silent_p.R387R	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	387	Cytoplasmic (By similarity).			R -> G (in Ref. 9; AAK77197).	activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	TCTTGGAGATCCTGTAGAAGG	0.557													43	79					0	0	1	0	0
PNOC	5368	broad.mit.edu	37	8	28196745	28196745	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:28196745C>T	uc010lva.2	+	3	523	c.315C>T	c.(313-315)TTC>TTT	p.F105F	PNOC_uc003xgp.2_Silent_p.F105F|PNOC_uc011lau.1_Silent_p.F41F	NM_006228	NP_006219	Q13519	PNOC_HUMAN	prepronociceptin precursor	105					neuropeptide signaling pathway|sensory perception|synaptic transmission	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(1)	1		Ovarian(32;0.000953)		KIRC - Kidney renal clear cell carcinoma(542;0.104)|Kidney(114;0.125)|Colorectal(74;0.145)|BRCA - Breast invasive adenocarcinoma(99;0.245)		GGAGCTTGTTCCAGGAGCAGG	0.642													15	17					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37720489	37720489	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:37720489A>G	uc003xkm.1	-	6	3820	c.3776T>C	c.(3775-3777)CTT>CCT	p.L1259P	RAB11FIP1_uc010lvz.1_Missense_Mutation_p.L473P|RAB11FIP1_uc003xkn.1_Missense_Mutation_p.L625P|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.L588P	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	1259	Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recycling.|FIP-RBD.				protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			GACCCTGACAAGCAGGTTGTC	0.483													51	73					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39442148	39442148	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:39442148C>T	uc003xni.2	+	1	7	c.7C>T	c.(7-9)CTT>TTT	p.L3F	ADAM18_uc003xnh.2_Missense_Mutation_p.L3F|ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.L3F	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	3					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			AGCCATGTTCCTTCTCCTCGC	0.627													24	30					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537394	55537394	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:55537394G>A	uc003xsd.1	+	4	1100	c.952G>A	c.(952-954)GAT>AAT	p.D318N	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	318					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCTGAAGATGATATTGAGAA	0.308													11	22					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537775	55537775	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:55537775C>T	uc003xsd.1	+	4	1481	c.1333C>T	c.(1333-1335)CGT>TGT	p.R445C	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	445					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AGCAAAGCATCGTTTTTATAG	0.438													18	37					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354406	57354406	+	Missense_Mutation	SNP	G	A	A	rs148519224		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:57354406G>A	uc003xsz.2	-	2	310	c.229C>T	c.(229-231)CCT>TCT	p.P77S	PENK_uc003xta.3_Missense_Mutation_p.P77S	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	77					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity	p.P77S(1)		ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CCATCTTGAGGAAGCTCTGGT	0.483													44	68					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69380963	69380963	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:69380963G>A	uc010lyz.2	+	4	435	c.386G>A	c.(385-387)AGG>AAG	p.R129K	C8orf34_uc010lyy.1_Missense_Mutation_p.R129K|C8orf34_uc003xyb.2_Missense_Mutation_p.R104K	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	129					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			TGGAACTGGAGGACTAAACCA	0.398													15	10					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69633613	69633613	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:69633613G>A	uc010lyz.2	+	10	1136	c.1087G>A	c.(1087-1089)GAA>AAA	p.E363K	C8orf34_uc003xyb.2_Missense_Mutation_p.E338K	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	363					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			GCCTGGGACTGAAGAAGCACT	0.294													4	14					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70981488	70981488	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:70981488T>G	uc003xym.2	-	2	810	c.608A>C	c.(607-609)CAC>CCC	p.H203P		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CAGAACGAAGTGCAGGTCCTC	0.602													25	39					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480350	73480350	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:73480350G>A	uc003xzb.2	+	2	969	c.381G>A	c.(379-381)GGG>GGA	p.G127G		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	127	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			ATTACTGGGGGATTGATGAGA	0.448													42	55					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848829	73848829	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:73848829C>T	uc003xzb.2	+	3	1827	c.1239C>T	c.(1237-1239)ATC>ATT	p.I413I		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	413	Helical; Name=Segment S6; (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CCCTTCCTATCCCAATTATTG	0.443													36	37					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765586	77765586	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:77765586C>T	uc003yav.2	+	10	6681	c.6294C>T	c.(6292-6294)ATC>ATT	p.I2098I	ZFHX4_uc003yau.1_Silent_p.I2143I|ZFHX4_uc003yaw.1_Silent_p.I2098I	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2098	Homeobox 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGCTAAAAATCCTGAGGGCTT	0.423										HNSCC(33;0.089)			11	20					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86050686	86050686	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:86050686G>A	uc003ycw.2	+	17	2970	c.2816G>A	c.(2815-2817)AGA>AAA	p.R939K	LRRCC1_uc003ycx.2_Missense_Mutation_p.R846K|LRRCC1_uc003ycy.2_Missense_Mutation_p.R919K	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	939					cell division|mitosis	centriole|nucleus					0						AAAGCGGAAAGAGACAAAAGT	0.323													21	48					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87242234	87242234	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:87242234C>T	uc003ydq.1	-	1	371	c.273G>A	c.(271-273)ACG>ACA	p.T91T	SLC7A13_uc003ydr.1_Silent_p.T91T	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	91	Helical; Name=3; (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						AAAAAGCAACCGTGGAGCCAA	0.463													12	23					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885109	88885109	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:88885109G>A	uc003ydz.2	-	1	1188	c.1091C>T	c.(1090-1092)CCC>CTC	p.P364L		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	364										ovary(1)	1						GGCCACACTGGGAATGTCGTT	0.602													21	26					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88886163	88886163	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:88886163C>T	uc003ydz.2	-	1	134	c.37G>A	c.(37-39)GAC>AAC	p.D13N		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	13										ovary(1)	1						TTCTGCTTGTCTGCTTCCTCG	0.522													20	28					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	92983035	92983035	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:92983035G>A	uc003yfd.2	-	10	1474	c.1390C>T	c.(1390-1392)CTG>TTG	p.L464L	RUNX1T1_uc003yfc.1_Silent_p.L437L|RUNX1T1_uc003yfe.1_Silent_p.L427L|RUNX1T1_uc010mao.2_Silent_p.L437L|RUNX1T1_uc011lgi.1_Silent_p.L475L|RUNX1T1_uc010man.1_Silent_p.L89L|RUNX1T1_uc003yfb.1_Silent_p.L427L	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	464					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A464S(1)		lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GCCTTCTGCAGCTCCGTCATC	0.597													16	18					0	0	1	0	0
INTS8	55656	broad.mit.edu	37	8	95869074	95869074	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:95869074C>T	uc003yhb.2	+	15	1948	c.1822C>T	c.(1822-1824)CGT>TGT	p.R608C	INTS8_uc003yha.1_Missense_Mutation_p.R608C|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.R435C	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	608					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					ACCGAAGCTTCGTCAGGTCAT	0.468													225	332					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100108602	100108602	+	Silent	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:100108602A>T	uc003yiv.2	+	4	465	c.354A>T	c.(352-354)TCA>TCT	p.S118S	VPS13B_uc003yiw.2_Silent_p.S118S|VPS13B_uc003yit.2_Silent_p.S118S|VPS13B_uc003yiu.1_Silent_p.S118S|VPS13B_uc003yis.2_Silent_p.S118S|VPS13B_uc011lgy.1_5'UTR	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	118					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GCACAAAATCATCAATCAAAC	0.378													22	25					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104898359	104898359	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:104898359C>T	uc003yls.2	+	2	1107	c.866C>T	c.(865-867)TCG>TTG	p.S289L	RIMS2_uc003ylp.2_Missense_Mutation_p.S511L|RIMS2_uc003ylw.2_Missense_Mutation_p.S319L|RIMS2_uc003ylq.2_Missense_Mutation_p.S319L|RIMS2_uc003ylr.2_Missense_Mutation_p.S319L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	542					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CGCCAGATTTCGTTGAGCAGT	0.428										HNSCC(12;0.0054)			14	19					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105010432	105010432	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:105010432C>T	uc003yls.2	+	16	2639	c.2398C>T	c.(2398-2400)CGC>TGC	p.R800C	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.R814C|RIMS2_uc003ylq.2_Missense_Mutation_p.R814C|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1084					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TACTCTACCTCGCTCCAGATA	0.353										HNSCC(12;0.0054)			18	35					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814408	106814408	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:106814408G>A	uc003ymd.2	+	8	2121	c.2098G>A	c.(2098-2100)GAA>AAA	p.E700K	ZFPM2_uc011lhs.1_Missense_Mutation_p.E431K	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	700	C2HC-type 3.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CAGCCGGCACGAAACATACAT	0.488													9	24					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814615	106814615	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:106814615C>T	uc003ymd.2	+	8	2328	c.2305C>T	c.(2305-2307)CCT>TCT	p.P769S	ZFPM2_uc011lhs.1_Missense_Mutation_p.P500S	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	769					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CCTCAATAATCCTTGTACCTC	0.473													9	26					0	0	1	0	0
OXR1	55074	broad.mit.edu	37	8	107704968	107704968	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:107704968C>T	uc011lht.1	+	6	640	c.541C>T	c.(541-543)CAT>TAT	p.H181Y	OXR1_uc003ymf.2_Missense_Mutation_p.H180Y|OXR1_uc011lhu.1_Missense_Mutation_p.H173Y|OXR1_uc010mcg.2_Intron|OXR1_uc003ymg.1_Missense_Mutation_p.H113Y|OXR1_uc003ymi.1_Missense_Mutation_p.H92Y	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	181					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			TCCTGATGTCCATCCAACAGA	0.333													12	19					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110454331	110454331	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:110454331G>A	uc003yne.2	+	35	4404	c.4300G>A	c.(4300-4302)GGG>AGG	p.G1434R		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1434	Extracellular (Potential).|IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTTTCTTAGAGGGATAGGATA	0.438										HNSCC(38;0.096)			16	24					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110984678	110984678	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:110984678C>T	uc003ynr.3	-	2	1142	c.800G>A	c.(799-801)AGG>AAG	p.R267K	KCNV1_uc010mcw.2_Missense_Mutation_p.R267K	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	267	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GAAGCGACACCTGTCCCGCAC	0.537													24	24					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118159343	118159343	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:118159343C>T	uc003yoh.2	+	2	452	c.222C>T	c.(220-222)CTC>CTT	p.L74L	SLC30A8_uc010mcz.2_Silent_p.L25L|SLC30A8_uc011lia.1_Silent_p.L25L|SLC30A8_uc003yog.2_Silent_p.L25L	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	74	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			AGTGGAAACTCTGTTCTGCTT	0.483													123	152					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118159376	118159376	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:118159376G>A	uc003yoh.2	+	2	485	c.255G>A	c.(253-255)ATG>ATA	p.M85I	SLC30A8_uc010mcz.2_Missense_Mutation_p.M36I|SLC30A8_uc011lia.1_Missense_Mutation_p.M36I|SLC30A8_uc003yog.2_Missense_Mutation_p.M36I	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	85	Helical; (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TCATTTTCATGATTGCAGAGG	0.438													70	107					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121457755	121457755	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:121457755C>T	uc003ypc.1	+	1	90	c.45C>T	c.(43-45)TTC>TTT	p.F15F	MRPL13_uc003ypa.2_5'Flank|MRPL13_uc010mdf.2_5'Flank|MTBP_uc003ypb.1_Silent_p.F15F|MTBP_uc011lie.1_RNA	NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	15					cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AAGGAAAATTCCCGTCGGCGG	0.592													26	33					0	0	1	0	0
ZHX1	11244	broad.mit.edu	37	8	124267422	124267422	+	Silent	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:124267422T>A	uc003yqe.2	-	3	1195	c.765A>T	c.(763-765)GCA>GCT	p.A255A	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Silent_p.A255A|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Silent_p.A255A	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	255					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			CAGGAAGAACTGCTGCTGGTG	0.413													34	44					0	0	1	0	0
ZHX1	11244	broad.mit.edu	37	8	124267425	124267425	+	Silent	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:124267425T>A	uc003yqe.2	-	3	1192	c.762A>T	c.(760-762)GCA>GCT	p.A254A	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Silent_p.A254A|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Silent_p.A254A	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	254					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			GAAGAACTGCTGCTGGTGTCA	0.408													34	43					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125072502	125072502	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:125072502C>T	uc003yqw.2	+	23	3162	c.2956C>T	c.(2956-2958)CGG>TGG	p.R986W	uc003yqy.1_RNA	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	986	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TGCCAACATTCGGCCGGTGCT	0.587													35	31					0	0	1	0	0
TMEM71	137835	broad.mit.edu	37	8	133769527	133769527	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:133769527C>T	uc003ytp.2	-	3	283	c.54G>A	c.(52-54)TTG>TTA	p.L18L	TMEM71_uc003ytn.2_Silent_p.L18L|TMEM71_uc003yto.2_Silent_p.L18L	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	18						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			ATTCTCTTTCCAACCTGGAAG	0.328													4	11					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139158293	139158293	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:139158293C>T	uc003yuy.2	-	15	3620	c.3449G>A	c.(3448-3450)GGG>GAG	p.G1150E	FAM135B_uc003yux.2_Missense_Mutation_p.G1051E|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.G712E|FAM135B_uc003yvb.2_Nonsense_Mutation_p.W677*	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1150										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGCACTGTTCCCTAAAAATGA	0.448										HNSCC(54;0.14)			21	33					0	0	1	0	0
KCNK9	51305	broad.mit.edu	37	8	140630866	140630866	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:140630866C>T	uc003yvf.1	-	2	824	c.760G>A	c.(760-762)GAG>AAG	p.E254K	KCNK9_uc003yvg.1_Missense_Mutation_p.E254K|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	254	Cytoplasmic (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			TCCCGCCGCTCATCCTCACTG	0.597													22	22					0	0	1	0	0
GML	2765	broad.mit.edu	37	8	143928018	143928018	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:143928018A>T	uc003yxg.2	+	4	479	c.389A>T	c.(388-390)GAG>GTG	p.E130V		NM_002066	NP_002057	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule	130	UPAR/Ly6.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane				central_nervous_system(2)	2	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GTAACTGAGGAGGAGCTTCCA	0.448													13	31					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144946560	144946560	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:144946560C>T	uc003zaa.1	-	1	875	c.862G>A	c.(862-864)GCC>ACC	p.A288T		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	288	Plectin 6.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACAACCCCGGCCACGCTGCCG	0.687													18	28					0	0	1	0	0
HEATR7A	727957	broad.mit.edu	37	8	145278091	145278091	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:145278091C>T	uc003zbk.3	+	14	1533	c.1296C>T	c.(1294-1296)ATC>ATT	p.I432I	HEATR7A_uc011lla.1_Silent_p.I432I|HEATR7A_uc010mft.2_Silent_p.I432I	NM_032450	NP_115826	Q8NDA8	HTR7A_HUMAN	HEAT repeat containing 7A isoform 1	432							binding				0						AGGCGATGATCGAGTACATCG	0.652													7	7					0	0	1	0	0
VPS28	51160	broad.mit.edu	37	8	145649477	145649477	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr8:145649477G>A	uc003zcr.1	-	8	548	c.495C>T	c.(493-495)CAC>CAT	p.H165H	VPS28_uc003zcs.1_Silent_p.H165H|VPS28_uc003zct.1_Silent_p.H165H	NM_016208	NP_057292	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 isoform 1	165	VPS28 C-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GGCTCATGCGGTGCATGGTCT	0.697													25	48					0	0	1	0	0
TYRP1	7306	broad.mit.edu	37	9	12698628	12698628	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:12698628T>G	uc003zkv.3	+	4	1064	c.886T>G	c.(886-888)TAT>GAT	p.Y296D		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	296	Lumenal, melanosome (Potential).				melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		CTTGGAAGATTATGATACCCT	0.398									Oculocutaneous_Albinism				13	8					0	0	1	0	0
TTC39B	158219	broad.mit.edu	37	9	15189610	15189610	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:15189610G>A	uc003zlr.1	-	13	1118	c.997C>T	c.(997-999)CAT>TAT	p.H333Y	TTC39B_uc003zlq.1_Missense_Mutation_p.H302Y|TTC39B_uc011lmp.1_Missense_Mutation_p.H234Y|TTC39B_uc010mie.1_Missense_Mutation_p.H331Y|TTC39B_uc011lmq.1_Intron|TTC39B_uc011lmr.1_Missense_Mutation_p.H264Y|TTC39B_uc010mif.1_Missense_Mutation_p.H333Y|TTC39B_uc003zls.1_Missense_Mutation_p.H234Y|TTC39B_uc010mig.1_Missense_Mutation_p.H302Y|TTC39B_uc003zlp.1_5'Flank	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	333	TPR 1.						binding			ovary(1)	1						ATTCGGGCATGATAAAACAAC	0.418													12	5					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17795676	17795676	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:17795676C>A	uc003zna.2	+	9	1282	c.994C>A	c.(994-996)CTG>ATG	p.L332M	SH3GL2_uc011lmy.1_Missense_Mutation_p.L285M	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	332	SH3.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		TGAGGGGATGCTGCATGGCCA	0.483													3	12					1	1	1	1	0
NFX1	4799	broad.mit.edu	37	9	33364754	33364754	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:33364754C>T	uc003zsq.2	+	21	3082	c.3021C>T	c.(3019-3021)CTC>CTT	p.L1007L	SUGT1P1_uc010mjq.1_Intron|NFX1_uc003zsp.1_Silent_p.L1007L|NFX1_uc010mjr.1_Silent_p.L1008L|NFX1_uc003zsr.2_Silent_p.L1008L	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	1007	R3H.				inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		TGGAAACCCTCGTGGAGGCCG	0.428													18	2					0	0	1	0	0
CCL27	10850	broad.mit.edu	37	9	34662354	34662354	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:34662354C>A	uc003zvm.1	-	2	189	c.130G>T	c.(130-132)GAC>TAC	p.D44Y		NM_006664	NP_006655	Q9Y4X3	CCL27_HUMAN	small inducible cytokine A27 precursor	44					cell-cell signaling|chemotaxis|immune response	extracellular space	chemokine activity				0	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		AGTAGCTTGTCTGAGAGTGGC	0.562													21	2					6.21321e-17	6.29635e-17	1	1	0
UNC13B	10497	broad.mit.edu	37	9	35370328	35370328	+	Missense_Mutation	SNP	C	T	T	rs143686793		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:35370328C>T	uc003zwq.2	+	12	1520	c.1228C>T	c.(1228-1230)CTC>TTC	p.L410F	UNC13B_uc010mkl.1_Silent_p.G417G|UNC13B_uc003zwr.2_Missense_Mutation_p.L410F	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	410					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			AGCCGGAGGGCTCTATGGCAT	0.512													20	8					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36171103	36171103	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:36171103C>T	uc003zzb.3	+	1	1715	c.1604C>T	c.(1603-1605)ACT>ATT	p.T535I		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	535	Kelch 6.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			GGTGTCACCACTGCCAGCGAT	0.537													32	8					0	0	1	0	0
RNF38	152006	broad.mit.edu	37	9	36390574	36390574	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:36390574G>A	uc003zzh.2	-	2	243	c.52C>T	c.(52-54)CCT>TCT	p.P18S	RNF38_uc003zzi.2_Intron|RNF38_uc003zzj.2_5'UTR|RNF38_uc003zzk.2_Intron|RNF38_uc003zzl.2_Intron|RNF38_uc003zzm.2_5'UTR	NM_022781	NP_073618	Q9H0F5	RNF38_HUMAN	ring finger protein 38 isoform 1	18							zinc ion binding			central_nervous_system(1)	1			STAD - Stomach adenocarcinoma(86;0.228)			ACCTTGTTAGGATGGCCAGGT	0.488													33	9					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39103850	39103850	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:39103850G>A	uc004abi.2	-	16	2666	c.2427C>T	c.(2425-2427)TTC>TTT	p.F809F	CNTNAP3_uc004abj.2_Silent_p.F808F|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Silent_p.F809F	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	809	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GTTCTCCGTGGAAAGCAGGGA	0.428													8	9					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77277428	77277428	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:77277428C>T	uc004aji.2	+	6	880	c.831C>T	c.(829-831)ATC>ATT	p.I277I	RORB_uc004ajh.2_Silent_p.I266I	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	277	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						CCATCCAGATCACTCACGCCA	0.463													42	10					0	0	1	0	0
FLJ46321	389763	broad.mit.edu	37	9	84605856	84605856	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:84605856C>T	uc004amn.2	+	4	518	c.471C>T	c.(469-471)TCC>TCT	p.S157S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	157						integral to membrane					0						CCTCTGTGTCCCCTTTGGCTT	0.562													16	8					0	0	1	0	0
C9orf79	286234	broad.mit.edu	37	9	90501213	90501213	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:90501213C>T	uc004app.3	+	4	1846	c.1811C>T	c.(1810-1812)CCG>CTG	p.P604L	C9orf79_uc004apo.1_Missense_Mutation_p.P416L	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	604						integral to membrane				ovary(3)	3						CAAGAGAGGCCGGCCTCCTGG	0.602													31	12					0	0	1	0	0
CENPP	401541	broad.mit.edu	37	9	95094460	95094460	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:95094460T>C	uc004arz.2	+	2	656	c.116T>C	c.(115-117)TTT>TCT	p.F39S	CENPP_uc010mqx.2_Intron|CENPP_uc004ary.1_Missense_Mutation_p.F39S	NM_001012267	NP_001012267	Q6IPU0	CENPP_HUMAN	centromere protein P	39	Potential.				CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				ovary(2)	2						AGAAAATCTTTTCAAGCCATA	0.333													7	1					0	0	1	0	0
ECM2	1842	broad.mit.edu	37	9	95277286	95277286	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:95277286C>T	uc004ash.2	-	4	746	c.681G>A	c.(679-681)AAG>AAA	p.K227K	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Silent_p.K205K|ECM2_uc011lty.1_Silent_p.K227K|ECM2_uc004asg.2_Silent_p.K205K	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	227					cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						GGGTCTCTCTCTTTTGCTCTG	0.498													84	26					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104499664	104499664	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:104499664G>A	uc004bbp.1	-	1	1199	c.598C>T	c.(598-600)CCC>TCC	p.P200S	GRIN3A_uc004bbq.1_Missense_Mutation_p.P200S	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	200	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TGGCTCTGGGGGAAGGCGAGC	0.592													13	5					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767024	105767024	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:105767024G>A	uc004bbs.2	+	4	298	c.228G>A	c.(226-228)TGG>TGA	p.W76*		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	76	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				AACCATTATGGATGTACCGTT	0.383													13	8					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361665	107361665	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:107361665C>T	uc011lvp.1	-	1	30	c.30G>A	c.(28-30)GTG>GTA	p.V10V		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GAAAAAATTCCACCAGAATGG	0.378													14	5					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113275228	113275228	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:113275228G>A	uc010mtz.2	-	5	1618	c.1281C>T	c.(1279-1281)TCC>TCT	p.S427S	SVEP1_uc010mua.1_Silent_p.S427S|SVEP1_uc004beu.2_Silent_p.S427S|SVEP1_uc004bev.2_Silent_p.S171S	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	427	Sushi 1.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TCTCTGAACCGGACCACAAAC	0.443													27	5					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119188178	119188178	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:119188178C>T	uc004bjs.1	-	23	4073	c.3972G>A	c.(3970-3972)AAG>AAA	p.K1324K	ASTN2_uc004bjr.1_Silent_p.K1320K|ASTN2_uc004bjt.1_Silent_p.K1273K|ASTN2_uc004bjp.1_Silent_p.K417K|ASTN2_uc004bjq.1_Silent_p.K376K|ASTN2_uc011lxr.1_Silent_p.K376K|ASTN2_uc011lxs.1_Intron|ASTN2_uc011lxt.1_Silent_p.K376K|ASTN2_uc004bjo.1_Silent_p.K105K	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1324	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TTGACACCATCTTCTCCTCAC	0.582													17	3					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119770425	119770425	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:119770425G>A	uc004bjs.1	-	7	1638	c.1537C>T	c.(1537-1539)CTC>TTC	p.L513F	ASTN2_uc004bjr.1_Missense_Mutation_p.L513F|ASTN2_uc004bjt.1_Missense_Mutation_p.L462F	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	513	Extracellular (Potential).|EGF-like 1.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TGTCCACAGAGGTCCCTCACC	0.587													20	8					0	0	1	0	0
OR1J1	347168	broad.mit.edu	37	9	125240122	125240122	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:125240122G>A	uc011lyu.1	-	1	84	c.84C>T	c.(82-84)TTC>TTT	p.F28F	OR1J2_uc004bmj.1_Intron	NM_001004451	NP_001004451	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GGAACAGGGCGAAGAACACGG	0.587													34	14					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486805	125486805	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:125486805C>T	uc004bmu.1	+	1	537	c.537C>T	c.(535-537)TTC>TTT	p.F179F		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCACTTTTTCTGTGACACCC	0.507													50	62					0	0	1	0	0
PBX3	5090	broad.mit.edu	37	9	128692114	128692114	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:128692114C>T	uc004bqb.2	+	4	813	c.697C>T	c.(697-699)CTT>TTT	p.L233F	PBX3_uc004bqc.2_Missense_Mutation_p.L52F|PBX3_uc004bqd.2_Missense_Mutation_p.L52F|PBX3_uc011lzw.1_Missense_Mutation_p.L158F|PBX3_uc011lzx.1_Missense_Mutation_p.L144F|PBX3_uc004bqe.2_Missense_Mutation_p.L120F	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	233					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						ATCAAGGTTCCTTGATGCCAG	0.403													19	9					0	0	1	0	0
QRFP	347148	broad.mit.edu	37	9	133769000	133769000	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:133769000T>C	uc011mcb.1	-	1	226	c.226A>G	c.(226-228)ACA>GCA	p.T76A		NM_198180	NP_937823	P83859	OX26_HUMAN	RF(Arg-Phe)amide family 26 amino acid peptide	76					locomotory behavior|neuropeptide signaling pathway|positive regulation of blood pressure|regulation of feeding behavior	extracellular region	neuropeptide hormone activity|orexigenic neuropeptide QRFP receptor binding				0	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.17e-05)|Epithelial(140;0.000267)		CTGCCCGATGTCTGCAGCCCC	0.667													30	13					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133948193	133948193	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:133948193C>T	uc004caa.1	+	19	3486	c.3388C>T	c.(3388-3390)CTG>TTG	p.L1130L		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1130	Domain II and I.|Potential.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		AGAGGAGATTCTGCATGCAGC	0.512													7	1					0	0	1	0	0
DBH	1621	broad.mit.edu	37	9	136501635	136501635	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:136501635C>T	uc004cel.2	+	1	151	c.142C>T	c.(142-144)CCC>TCC	p.P48S		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	48	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	GAGCCCCCTCCCCTATCACAT	0.642													22	3					0	0	1	0	0
C9orf163	158055	broad.mit.edu	37	9	139379478	139379479	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:139379478_139379479CC>TT	uc004chy.2	+	1	1532_1533	c.578_579CC>TT	c.(577-579)TCC>TTT	p.S193F	SEC16A_uc004chx.2_5'Flank|SEC16A_uc010nbo.1_5'Flank	NM_152571	NP_689784	Q8N9P6	CI163_HUMAN	hypothetical protein LOC158055	193							protein binding				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.36e-06)|Epithelial(140;5.65e-06)		CTAGGGTCCTCCGAAACCCTGT	0.604											OREG0019617	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	4					0	0	1	0	0
LCN10	414332	broad.mit.edu	37	9	139635432	139635432	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:139635432G>C	uc010nbq.2	-	3	351	c.292C>G	c.(292-294)CCG>GCG	p.P98A	LCN10_uc004civ.2_Intron|LCN10_uc011med.1_Intron|LCN10_uc011mee.1_Intron|LCN10_uc011mef.1_Intron|LCN10_uc004ciw.2_Intron			Q6JVE6	LCN10_HUMAN	SubName: Full=LCN10 protein;	98					transport	extracellular region	binding			large_intestine(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.32e-06)|Epithelial(140;7.83e-05)		CTGGTTCCCGGATGGCGTGGC	0.657													2	0					0	0	1	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071154	141071154	+	Missense_Mutation	SNP	T	C	C	rs150819761	by1000genomes	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:141071154T>C	uc004com.2	+	4	818	c.557T>C	c.(556-558)GTC>GCC	p.V186A	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						GTGAACATGGTCCCGTTTCCC	0.632													4	29					0	0	1	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071195	141071195	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr9:141071195C>T	uc004com.2	+	4	859	c.598C>T	c.(598-600)CCA>TCA	p.P200S	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TGGCTTTGCCCCACTGACCAG	0.622													7	38					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2947360	2947361	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:2947360_2947361CC>TT	uc011mhj.1	+	8	1272_1273	c.1272_1273CC>TT	c.(1270-1275)TTCCAC>TTTTAC	p.H425Y		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	425						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AGTTCCTCTTCCACTACTGTGG	0.569													47	8					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3002495	3002495	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:3002495G>A	uc004cre.1	+	6	839	c.618G>A	c.(616-618)GGG>GGA	p.G206G	ARSF_uc004crf.1_Silent_p.G206G	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	206						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TAACCTTTGGGAAGCTGAGCG	0.547													38	10					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3228960	3228960	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:3228960C>T	uc004crg.3	-	7	7441	c.7284G>A	c.(7282-7284)AGG>AGA	p.R2428R		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2428	Ig-like C2-type 8.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACACCGTCTTCCTATCCTCTC	0.562													25	10					0	0	1	0	0
GRPR	2925	broad.mit.edu	37	X	16170504	16170504	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:16170504C>T	uc004cxj.2	+	3	1544	c.891C>T	c.(889-891)TCC>TCT	p.S297S		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	297	Extracellular (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					TGGACACCTCCATGCTCCACT	0.567													86	19					0	0	1	0	0
SCML2	10389	broad.mit.edu	37	X	18278362	18278362	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:18278362G>A	uc004cyl.2	-	9	1155	c.998C>T	c.(997-999)TCG>TTG	p.S333L	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.S333L|SCML2_uc011miz.1_Missense_Mutation_p.S267L|SCML2_uc010nfc.2_Missense_Mutation_p.S69L	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	333					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					TCTGGTCAGCGATTTTAGAGA	0.338													19	6					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23929948	23929948	+	Missense_Mutation	SNP	T	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:23929948T>A	uc004daz.1	+	3	535	c.191T>A	c.(190-192)CTC>CAC	p.L64H	CXorf58_uc011mju.1_Missense_Mutation_p.L64H	NM_152761	NP_689974	Q96LI9	CX058_HUMAN	hypothetical protein LOC254158	64											0						ATATTTCGACTCCTAAAACAC	0.303													44	36					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27840366	27840366	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:27840366G>A	uc004dbw.2	+	3	1170	c.943G>A	c.(943-945)GAA>AAA	p.E315K		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	315										lung(1)|breast(1)|central_nervous_system(1)	3						ACAAGATGAGGAAGAGAGAGC	0.488													15	2					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31462650	31462650	+	Missense_Mutation	SNP	G	A	A	rs143925896	byFrequency	TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:31462650G>A	uc004dda.1	-	60	9276	c.9032C>T	c.(9031-9033)CCG>CTG	p.P3011L	DMD_uc004dcq.1_Missense_Mutation_p.P282L|DMD_uc004dcr.1_Missense_Mutation_p.P551L|DMD_uc004dcs.1_Missense_Mutation_p.P551L|DMD_uc004dct.1_Missense_Mutation_p.P551L|DMD_uc004dcu.1_Missense_Mutation_p.P551L|DMD_uc004dcv.1_Missense_Mutation_p.P551L|DMD_uc004dcw.2_Missense_Mutation_p.P1667L|DMD_uc004dcx.2_Missense_Mutation_p.P1670L|DMD_uc004dcz.2_Missense_Mutation_p.P2888L|DMD_uc004dcy.1_Missense_Mutation_p.P3007L|DMD_uc004ddb.1_Missense_Mutation_p.P3003L	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3011	Spectrin 22.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GAGGTTATACGGTGAGAGCTG	0.463													25	14					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34150245	34150245	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:34150245C>T	uc004ddg.2	-	1	184	c.151G>A	c.(151-153)GTG>ATG	p.V51M		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	51										ovary(4)|central_nervous_system(1)	5						CCCTCCTTCACAAATACCCAG	0.547													34	13					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35974140	35974140	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:35974140T>C	uc004ddj.2	+	8	1296	c.1237T>C	c.(1237-1239)TTT>CTT	p.F413L	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	413										large_intestine(1)|lung(1)|ovary(1)	3						TTTACTACAGTTTGATCCAGG	0.368													32	12					0	0	1	0	0
DDX3X	1654	broad.mit.edu	37	X	41205854	41205854	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:41205854A>G	uc004dfe.2	+	14	2449	c.1594A>G	c.(1594-1596)ACG>GCG	p.T532A	DDX3X_uc004dff.2_Missense_Mutation_p.T532A|DDX3X_uc011mkq.1_Missense_Mutation_p.T516A|DDX3X_uc011mkr.1_Intron|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	532	Helicase C-terminal.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						TATTGGTCGTACGGGACGTGT	0.378										HNSCC(61;0.18)			39	11					0	0	1	0	0
ZNF630	57232	broad.mit.edu	37	X	47918844	47918844	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:47918844G>A	uc004div.3	-	5	1239	c.987C>T	c.(985-987)TCC>TCT	p.S329S	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Silent_p.S205S	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	329	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						GTGACTTCCGGGAGAATGCTC	0.438													19	9					0	0	1	0	0
SSX7	280658	broad.mit.edu	37	X	52682454	52682454	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:52682454C>T	uc004dqx.1	-	2	228	c.69G>A	c.(67-69)AAG>AAA	p.K23K		NM_173358	NP_775494	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7	23	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			skin(1)	1	Ovarian(276;0.236)					GTCACCTCACCTTTTGGATCT	0.562													71	27					0	0	1	0	0
FGD1	2245	broad.mit.edu	37	X	54497798	54497798	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:54497798G>A	uc004dtg.2	-	2	1164	c.430C>T	c.(430-432)CCT>TCT	p.P144S	FGD1_uc011moi.1_5'Flank	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	144	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CGCTGGCTAGGGGTTTCAGTC	0.612													23	10					0	0	1	0	0
IGBP1	3476	broad.mit.edu	37	X	69385761	69385761	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:69385761G>A	uc004dxv.2	+	6	1449	c.950G>A	c.(949-951)AGA>AAA	p.R317K	IGBP1_uc004dxw.2_Missense_Mutation_p.R317K	NM_001551	NP_001542	P78318	IGBP1_HUMAN	immunoglobulin binding protein 1	317					B cell activation|negative regulation of caspase activity|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|regulation of microtubule-based movement|response to interleukin-1|response to tumor necrosis factor|signal transduction	cytoplasm	protein phosphatase type 2A regulator activity			kidney(1)|pancreas(1)	2						ACACTCCACAGAGCCCGGGAG	0.493													10	1					0	0	1	0	0
AWAT1	158833	broad.mit.edu	37	X	69459767	69459767	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:69459767G>A	uc004dxy.2	+	6	856	c.815G>A	c.(814-816)AGG>AAG	p.R272K		NM_001013579	NP_001013597	Q58HT5	AWAT1_HUMAN	wax synthase 1	272					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			ovary(3)	3						CCATACTCCAGGCCTATTGTC	0.547													23	3					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72433704	72433704	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:72433704C>T	uc004ebi.2	-	1	981	c.625G>A	c.(625-627)GAT>AAT	p.D209N	NAP1L2_uc011mqj.1_Missense_Mutation_p.D67N	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	209	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					ACAGCATAATCATAATAATAG	0.343													20	3					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046766	73046766	+	RNA	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:73046766C>T	uc004ebn.2	+	1		c.34727C>T			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						CTTGAGACTTCCATCCAACTC	0.483													36	14					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84362528	84362528	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:84362528C>T	uc011mqx.1	-	1	1447	c.1447G>A	c.(1447-1449)GAA>AAA	p.E483K	SATL1_uc004een.2_Missense_Mutation_p.E483K	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	296	Gln-rich.						N-acetyltransferase activity			breast(2)	2						GGCCCCGGTTCCCATATGCCT	0.572													35	12					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99662304	99662304	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:99662304G>A	uc010nmz.2	-	1	2968	c.1292C>T	c.(1291-1293)CCC>CTC	p.P431L	PCDH19_uc004efw.3_Missense_Mutation_p.P431L|PCDH19_uc004efx.3_Missense_Mutation_p.P431L	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	431	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CTGCAGCATGGGCACGCCGCC	0.557													46	14					0	0	1	0	0
BTK	695	broad.mit.edu	37	X	100625006	100625006	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:100625006C>T	uc004ehg.2	-	5	564	c.371G>A	c.(370-372)TGG>TAG	p.W124*	BTK_uc010nnn.2_Nonsense_Mutation_p.W124*|BTK_uc010nno.2_Nonsense_Mutation_p.W158*|BTK_uc004ehi.2_Nonsense_Mutation_p.W124*	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	124	PH.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						CTGGTGAATCCACCGCTTCCT	0.343									Agammaglobulinemia_X-linked				43	8					0	0	1	0	0
RNF128	79589	broad.mit.edu	37	X	105970251	105970251	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:105970251C>T	uc004eml.2	+	1	358	c.108C>T	c.(106-108)TCC>TCT	p.S36S	RNF128_uc004emk.2_Intron	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	36						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						CACCCGGTTCCCGGGGGGCTG	0.697													4	3					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107431128	107431128	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:107431128C>T	uc004enw.3	-	22	1823	c.1720G>A	c.(1720-1722)GAA>AAA	p.E574K	COL4A6_uc004env.3_Missense_Mutation_p.E573K|COL4A6_uc011msn.1_Missense_Mutation_p.E573K|COL4A6_uc010npk.2_Missense_Mutation_p.E573K	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	574	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						TTGCCTGGTTCTCCTATTACA	0.522									Alport_syndrome_with_Diffuse_Leiomyomatosis				56	19					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107814658	107814658	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:107814658C>T	uc004enz.1	+	7	602	c.400C>T	c.(400-402)CCA>TCA	p.P134S	COL4A5_uc011mso.1_Missense_Mutation_p.P134S	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	134	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						ACGTGGATTTCCAGGCAGTCC	0.368									Alport_syndrome_with_Diffuse_Leiomyomatosis				80	31					0	0	1	0	0
LRCH2	57631	broad.mit.edu	37	X	114357710	114357710	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:114357710C>T	uc010nqe.2	-	18	1926	c.1895G>A	c.(1894-1896)GGA>GAA	p.G632E	LRCH2_uc004epz.2_Missense_Mutation_p.G615E	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)	632										ovary(1)	1						CATTGTAAATCCTGGATCTGC	0.408													11	1					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117079508	117079508	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:117079508C>T	uc004eql.2	-	2	191	c.129G>A	c.(127-129)ATG>ATA	p.M43I	KLHL13_uc004eqk.2_5'UTR|KLHL13_uc011mtn.1_5'UTR|KLHL13_uc011mto.1_Missense_Mutation_p.M37I|KLHL13_uc011mtp.1_Missense_Mutation_p.M45I|KLHL13_uc004eqm.2_5'UTR|KLHL13_uc011mtq.1_Missense_Mutation_p.M27I	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	43					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						GGGACAATTTCATGTGTTGGT	0.413													15	9					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117744354	117744354	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:117744354G>A	uc004eqp.2	+	28	3132	c.3069G>A	c.(3067-3069)GTG>GTA	p.V1023V	DOCK11_uc004eqq.2_Silent_p.V789V	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1023					blood coagulation	cytosol	GTP binding			ovary(3)	3						CCAGAAATGTGAACTATAGTT	0.423													34	7					0	0	1	0	0
LONRF3	79836	broad.mit.edu	37	X	118123394	118123394	+	Silent	SNP	T	C	C			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:118123394T>C	uc004eqw.2	+	4	1114	c.1083T>C	c.(1081-1083)TGT>TGC	p.C361C	LONRF3_uc004eqx.2_Silent_p.C320C|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_Silent_p.C105C	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	361					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						TCCCACATTGTTCTAGTCAGG	0.502													30	9					0	0	1	0	0
ODZ1	10178	broad.mit.edu	37	X	123518570	123518570	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:123518570G>A	uc004euj.2	-	29	6254	c.6190C>T	c.(6190-6192)CTT>TTT	p.L2064F	ODZ1_uc011muj.1_Missense_Mutation_p.L2070F|ODZ1_uc010nqy.2_Missense_Mutation_p.L2071F	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2064	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TATCGGTAAAGATCTATAGGC	0.393													43	11					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685552	125685552	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:125685552C>T	uc004eul.2	-	1	1291	c.1040G>A	c.(1039-1041)CGA>CAA	p.R347Q		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	347										skin(3)|ovary(1)	4						GCCACCCTCTCGAGAACACAG	0.612													25	4					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125686156	125686156	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:125686156C>T	uc004eul.2	-	1	687	c.436G>A	c.(436-438)GAC>AAC	p.D146N		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	146										skin(3)|ovary(1)	4						CCCTGTTGGTCCTGGGCCAGC	0.632													16	6					0	0	1	0	0
HS6ST2	90161	broad.mit.edu	37	X	131762479	131762479	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:131762479G>A	uc011mve.1	-	4	2006	c.1590C>T	c.(1588-1590)TTC>TTT	p.F530F	HS6ST2_uc011mvb.1_Silent_p.F424F|HS6ST2_uc011mvc.1_Silent_p.F384F|HS6ST2_uc011mvd.1_Silent_p.F570F|HS6ST2_uc011mva.1_Silent_p.F256F	NM_147175	NP_671704	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2 isoform	530	Lumenal (Potential).					integral to membrane	sulfotransferase activity				0	Acute lymphoblastic leukemia(192;0.000127)					CCTGGCTCTGGAAATGGGTCT	0.308													22	9					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134990307	134990307	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:134990307G>A	uc004ezh.2	+	11	1386	c.1219G>A	c.(1219-1221)GAT>AAT	p.D407N	SAGE1_uc010nry.1_Missense_Mutation_p.D376N|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	407										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					ACCAACCCCTGATAACGTCTT	0.443													40	11					0	0	1	0	0
ATP11C	286410	broad.mit.edu	37	X	138828016	138828016	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:138828016C>T	uc004faz.2	-	25	2937	c.2838G>A	c.(2836-2838)ATG>ATA	p.M946I	ATP11C_uc004fax.2_Missense_Mutation_p.M154I|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.M946I	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	946	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					CAGAAATTTTCCTATTGAGAA	0.403													34	8					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994128	140994128	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:140994128C>T	uc004fbt.2	+	4	1224	c.938C>T	c.(937-939)TCC>TTC	p.S313F	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	313							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCCTCCTCCACTTTATTG	0.483										HNSCC(15;0.026)			96	38					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795344	142795344	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:142795344C>T	uc004fbz.2	-	2	1088	c.334G>A	c.(334-336)GAC>AAC	p.D112N		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	112										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTCTTCGTCCTCCTGTGAA	0.527													14	204					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795383	142795383	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:142795383C>T	uc004fbz.2	-	2	1049	c.295G>A	c.(295-297)GAC>AAC	p.D99N		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	99										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTCTTCGTCCTCCTGTGAA	0.522													158	67					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151123209	151123209	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:151123209G>A	uc004ffi.2	-	9	1539	c.1485C>T	c.(1483-1485)TTC>TTT	p.F495F	GABRE_uc011myd.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	495	Helical; (Potential).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGCACATTGAAGAAGAAGA	0.537													10	6					0	0	1	0	0
GABRQ	55879	broad.mit.edu	37	X	151820083	151820083	+	Silent	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:151820083C>T	uc004ffp.1	+	8	1016	c.996C>T	c.(994-996)ATC>ATT	p.I332I		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	332	Helical; (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATATCTATATCCTCGTGTGCT	0.478													57	19					0	0	1	0	0
GABRQ	55879	broad.mit.edu	37	X	151821280	151821280	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:151821280C>T	uc004ffp.1	+	9	1455	c.1435C>T	c.(1435-1437)CCT>TCT	p.P479S		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	479						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAGTATTTTTCCTACCGAAAT	0.542													57	18					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900189	151900189	+	Silent	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:151900189G>A	uc010ntp.2	-	3	966	c.612C>T	c.(610-612)ATC>ATT	p.I204I	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Silent_p.I204I	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	204	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TGGCCAGGACGATTATCAGGA	0.577													77	18					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900710	151900710	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:151900710G>A	uc010ntp.2	-	3	445	c.91C>T	c.(91-93)CCT>TCT	p.P31S	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.P31S|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	31										skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGTAGCAGGAGCCTGCGCA	0.622													25	9					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153689549	153689549	+	Silent	SNP	C	T	T	rs148620908		TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chrX:153689549C>T	uc004flm.2	+	3	878	c.705C>T	c.(703-705)TTC>TTT	p.F235F		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	235	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCGCCTCCTTCGTGTACTTCC	0.557													36	13					0	0	1	0	0
ZNF124	7678	broad.mit.edu	37	1	247319908	247319909	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr1:247319908_247319909insT	uc001ick.2	-	4	1154_1155	c.1015_1016insA	c.(1015-1017)ACTfs	p.T339fs	ZNF124_uc001ici.2_Intron|ZNF124_uc001icj.1_Frame_Shift_Ins_p.T277fs	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	339	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			TCCAGTATGAGTTTTTTTATGC	0.366													35	34	---	---	---	---					
DHCR7	1717	broad.mit.edu	37	11	71152336	71152339	+	Frame_Shift_Del	DEL	CCAA	-	-			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr11:71152336_71152339delCCAA	uc001oqk.2	-	6	810_813	c.560_563delTTGG	c.(559-564)CTTGGCfs	p.L187fs	DHCR7_uc001oql.2_Frame_Shift_Del_p.L187fs	NM_001163817	NP_001157289	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	187_188	Helical; (Potential).				cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			ovary(1)|liver(1)	2					NADH(DB00157)	GACGGCATAGCCAAGGATGTTGGC	0.564									Smith-Lemli-Opitz_syndrome				25	40	---	---	---	---					
RECQL	5965	broad.mit.edu	37	12	21639515	21639515	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr12:21639515delA	uc001rex.2	-	6	747	c.399delT	c.(397-399)TTTfs	p.F133fs	RECQL_uc001rey.2_Frame_Shift_Del_p.F133fs	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	133	Helicase ATP-binding.				DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						TGACGAGTGTAAAACCTAAAA	0.294								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					9	28	---	---	---	---					
CCNF	899	broad.mit.edu	37	16	2493679	2493680	+	In_Frame_Ins	INS	-	AAC	AAC			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr16:2493679_2493680insAAC	uc002cqd.1	+	9	895_896	c.807_808insAAC	c.(805-810)insAAC	p.270_271insN	CCNF_uc002cqe.1_5'UTR	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	270_271					cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				GTGCAAATGCAAACCAGCTTGG	0.485													32	64	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9064536	9064536	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:9064536delT	uc002mkp.2	-	3	23114	c.22910delA	c.(22909-22911)AATfs	p.N7637fs		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7639	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTGTTCAAATTAAGGGTACT	0.483													58	7	---	---	---	---					
FCGBP	8857	broad.mit.edu	37	19	40376854	40376856	+	In_Frame_Del	DEL	CTT	-	-			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr19:40376854_40376856delCTT	uc002omp.3	-	24	11574_11576	c.11566_11568delAAG	c.(11566-11568)AAGdel	p.K3856del		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	3856	VWFD 9.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCTTCTGATACTTCTTCTCCAGC	0.655													11	14	---	---	---	---					
DNAH7	56171	broad.mit.edu	37	2	196922781	196922781	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr2:196922781delA	uc002utj.3	-	2	176	c.75delT	c.(73-75)TCTfs	p.S25fs		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	25	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AAATTACCATAGACAGCTGTG	0.308													22	58	---	---	---	---					
DDIT4L	115265	broad.mit.edu	37	4	101109270	101109271	+	In_Frame_Ins	INS	-	ATATTACCT	ATATTACCT			TCGA-FS-A1Z3-06A-11D-A197-08	TCGA-FS-A1Z3-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	7bdec899-4455-4bfc-8d68-2a30c123f6eb	0e60cc76-c521-43f9-ab13-4e63e7b72919	g.chr4:101109270_101109271insATATTACCT	uc003hvq.2	-	3	348_349	c.145_146insAGGTAATAT	c.(145-147)TTT>TAGGTAATATTT	p.48_49ins*VI		NM_145244	NP_660287	Q96D03	DDT4L_HUMAN	DNA-damage-inducible transcript 4-like	48_49					negative regulation of signal transduction	cytoplasm				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;5.75e-09)		TGATTCCTCAAATATTACCTCG	0.366													12	61	---	---	---	---					
