Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PHACTR4	65979	broad.mit.edu	37	1	28800112	28800112	+	Silent	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr1:28800112G>A	uc001bpw.2	+	7	1152	c.870G>A	c.(868-870)CCG>CCA	p.P290P	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Silent_p.P274P|PHACTR4_uc001bpy.2_Silent_p.P300P	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	290	Pro-rich.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TATCAAAACCGTCCCCACCCT	0.463												
C1orf141	400757	broad.mit.edu	37	1	67561965	67561965	+	Missense_Mutation	SNP	A	G	G			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr1:67561965A>G	uc001ddl.1	-	5	497	c.386T>C	c.(385-387)GTT>GCT	p.V129A	C1orf141_uc001ddm.1_Missense_Mutation_p.V129A|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	129										ovary(1)	1						TAAGAGACCAACAGAATCCAA	0.259												
WDR63	126820	broad.mit.edu	37	1	85551548	85551548	+	Missense_Mutation	SNP	T	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr1:85551548T>A	uc001dkt.2	+	7	766	c.575T>A	c.(574-576)TTT>TAT	p.F192Y	WDR63_uc009wcl.2_Missense_Mutation_p.F192Y	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	192										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		CGAAGTGAATTTGGTGCACCA	0.313												
PGLYRP4	57115	broad.mit.edu	37	1	153313050	153313050	+	Missense_Mutation	SNP	G	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr1:153313050G>C	uc001fbo.2	-	7	696	c.631C>G	c.(631-633)CCC>GCC	p.P211A	PGLYRP4_uc001fbp.2_Missense_Mutation_p.P207A	NM_020393	NP_065126	Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein-I-beta	211					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)|skin(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACAACGCCGGGGCAAGCTGAG	0.587												
KIFAP3	22920	broad.mit.edu	37	1	169951166	169951166	+	Missense_Mutation	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr1:169951166G>A	uc001ggv.2	-	15	2016	c.1745C>T	c.(1744-1746)GCT>GTT	p.A582V	KIFAP3_uc010plx.1_Missense_Mutation_p.A284V	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	582	ARM 4.				blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TAGCAATGCAGCACAAGAGTC	0.343												
ANKRD26	22852	broad.mit.edu	37	10	27350076	27350076	+	Missense_Mutation	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr10:27350076T>C	uc001ith.2	-	13	1631	c.1459A>G	c.(1459-1461)ATG>GTG	p.M487V	ANKRD26_uc001itg.2_Intron|ANKRD26_uc009xku.1_Missense_Mutation_p.M487V	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	487						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TCCATACCCATGTGGGCTACT	0.348												
MPP7	143098	broad.mit.edu	37	10	28409253	28409254	+	Missense_Mutation	DNP	CA	AG	AG			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr10:28409253_28409254CA>AG	uc001iua.1	-	12	1160_1161	c.756_757TG>CT	c.(754-759)GCTGGG>GCCTGG	p.G253W	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Missense_Mutation_p.G253W|MPP7_uc009xla.2_Missense_Mutation_p.G253W|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	253	SH3.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						AAAGAAAGCCCAGCTTCCTTAC	0.406												
BMS1	9790	broad.mit.edu	37	10	43316067	43316067	+	Missense_Mutation	SNP	G	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr10:43316067G>C	uc001jaj.2	+	17	3239	c.2881G>C	c.(2881-2883)GAC>CAC	p.D961H		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	961					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						TTATATCGAAGACCACAATGG	0.428												
BICC1	80114	broad.mit.edu	37	10	60553292	60553292	+	Missense_Mutation	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr10:60553292G>A	uc001jki.1	+	9	1096	c.1096G>A	c.(1096-1098)GTA>ATA	p.V366I	BICC1_uc001jkj.1_Missense_Mutation_p.V7I	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	366					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						AGAAATTGAAGTAGATCCACA	0.368												
OR5L1	219437	broad.mit.edu	37	11	55579759	55579759	+	Missense_Mutation	SNP	G	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr11:55579759G>T	uc001nhw.1	+	1	817	c.817G>T	c.(817-819)GTG>TTG	p.V273L		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TGCTGACAAAGTGGCCACCGT	0.473												
OR5B12	390191	broad.mit.edu	37	11	58207194	58207194	+	Missense_Mutation	SNP	A	G	G			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr11:58207194A>G	uc010rkh.1	-	1	431	c.431T>C	c.(430-432)ATA>ACA	p.I144T		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GTAGGAGCCTATGGCCAGGCA	0.463												
IGHMBP2	3508	broad.mit.edu	37	11	68704092	68704092	+	Missense_Mutation	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr11:68704092G>A	uc001ook.1	+	13	2246	c.2144G>A	c.(2143-2145)GGC>GAC	p.G715D	IGHMBP2_uc001ool.1_Missense_Mutation_p.G339D|IGHMBP2_uc001oom.1_Missense_Mutation_p.G293D	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	715	SS DNA-binding (By similarity).				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTCAACGGAGGCAGCCCAGAG	0.617												
TMEM133	83935	broad.mit.edu	37	11	100863381	100863381	+	Silent	SNP	G	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr11:100863381G>T	uc001pgf.2	+	1	571	c.342G>T	c.(340-342)GTG>GTT	p.V114V		NM_032021	NP_114410	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	114	Helical; (Potential).					integral to membrane					0		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		TTCAAAATGTGCCAGTTCCAC	0.373												
TAS2R9	50835	broad.mit.edu	37	12	10962585	10962585	+	Silent	SNP	A	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr12:10962585A>T	uc001qyx.2	-	1	183	c.90T>A	c.(88-90)GTT>GTA	p.V30V		NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	30	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						CAATGCAGTTAACTAGTACAA	0.388												
BIN2	51411	broad.mit.edu	37	12	51685543	51685543	+	Silent	SNP	C	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr12:51685543C>T	uc001ryg.2	-	10	1399	c.1347G>A	c.(1345-1347)AGG>AGA	p.R449R	BIN2_uc009zlz.2_Silent_p.R417R|BIN2_uc001ryh.2_Silent_p.R325R|BIN2_uc010sng.1_Silent_p.R423R	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	449	Pro-rich.					cytoplasm	protein binding			ovary(1)	1						CCAAGGAGGCCCTAGGGCTGG	0.612												
R3HDM2	22864	broad.mit.edu	37	12	57648757	57648757	+	Silent	SNP	A	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr12:57648757A>C	uc009zpm.1	-	22	2765	c.2730T>G	c.(2728-2730)GGT>GGG	p.G910G	R3HDM2_uc010srn.1_Intron|R3HDM2_uc001snu.2_Silent_p.G605G|R3HDM2_uc001snr.2_Silent_p.G637G|R3HDM2_uc001sns.2_Silent_p.G910G|R3HDM2_uc001snt.2_Silent_p.G924G|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	910	Poly-Gly.					nucleus	nucleic acid binding			ovary(2)	2						TGTCCCCCCCACCCCCTCCAG	0.632												
IRAK3	11213	broad.mit.edu	37	12	66638935	66638935	+	Missense_Mutation	SNP	C	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr12:66638935C>A	uc001sth.2	+	11	1309	c.1207C>A	c.(1207-1209)CTA>ATA	p.L403I	IRAK3_uc010ssy.1_Missense_Mutation_p.L342I	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	403	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		TCTCTCATTTCTAGATAAGAA	0.478												
ATP11A	23250	broad.mit.edu	37	13	113510350	113510350	+	Missense_Mutation	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr13:113510350G>A	uc001vsi.3	+	20	2457	c.2369G>A	c.(2368-2370)AGC>AAC	p.S790N	ATP11A_uc001vsj.3_Missense_Mutation_p.S790N|ATP11A_uc001vsm.1_Missense_Mutation_p.S666N|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	790	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				ATCTGCCGGAGCTGCAGCGCG	0.597												
DCAF11	80344	broad.mit.edu	37	14	24588926	24588926	+	Missense_Mutation	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr14:24588926T>C	uc001wlv.2	+	11	1193	c.913T>C	c.(913-915)TCC>CCC	p.S305P	DCAF11_uc001wlw.2_Missense_Mutation_p.S305P|DCAF11_uc001wlz.2_Missense_Mutation_p.S205P|DCAF11_uc001wly.2_Missense_Mutation_p.S261P|DCAF11_uc001wme.2_Missense_Mutation_p.S265P|DCAF11_uc010tny.1_Missense_Mutation_p.S172P|DCAF11_uc001wmd.2_Missense_Mutation_p.S305P|DCAF11_uc001wmc.2_Missense_Mutation_p.S205P|DCAF11_uc001wmb.3_Missense_Mutation_p.S279P|DCAF11_uc001wma.3_Missense_Mutation_p.S305P	NM_001163484	NP_001156956	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11 isoform 1	305	WD 4.					CUL4 RING ubiquitin ligase complex	protein binding				0						CTAGATTGAGTCCCATGAGGA	0.483												
GRAMD2	196996	broad.mit.edu	37	15	72460907	72460907	+	Missense_Mutation	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr15:72460907T>C	uc002atq.2	-	4	217	c.193A>G	c.(193-195)ATA>GTA	p.I65V	GRAMD2_uc010bis.2_Missense_Mutation_p.I65V	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	65						integral to membrane					0						TTCAGTGTTATCTGCAAACAC	0.542												
IDH3A	3419	broad.mit.edu	37	15	78454015	78454015	+	Missense_Mutation	SNP	G	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr15:78454015G>T	uc002bdd.2	+	5	409	c.382G>T	c.(382-384)GTC>TTC	p.V128F	IDH3A_uc010umt.1_Intron|IDH3A_uc010umu.1_Missense_Mutation_p.V19F|IDH3A_uc002bde.2_Missense_Mutation_p.V78F|IDH3A_uc010umv.1_Missense_Mutation_p.V78F|IDH3A_uc002bdf.2_5'UTR|IDH3A_uc002bdg.2_Missense_Mutation_p.V41F	NM_005530	NP_005521	P50213	IDH3A_HUMAN	isocitrate dehydrogenase 3 (NAD+) alpha	128					carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	CCGACCATGTGTCTCTATCGA	0.443												
GOLGA6L10	647042	broad.mit.edu	37	15	83014106	83014106	+	Silent	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr15:83014106T>C	uc010uny.1	-	6	539	c.441A>G	c.(439-441)GTA>GTG	p.V147V	GOLGA6L10_uc010unt.1_RNA|uc002bhl.2_Intron|uc002bhm.2_Intron|GOLGA6L10_uc002bia.1_5'Flank	NM_198181	NP_937824	A6NI86	GG6LA_HUMAN	golgi autoantigen, golgin subfamily a, 6D-like	159	Potential.										0						GTAGCTGCTCTACCTTAGATG	0.498												
PARN	5073	broad.mit.edu	37	16	14704541	14704541	+	Missense_Mutation	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr16:14704541T>C	uc010uzd.1	-	7	656	c.514A>G	c.(514-516)ACG>GCG	p.T172A	PARN_uc010uzc.1_Missense_Mutation_p.T111A|PARN_uc010uze.1_Missense_Mutation_p.T126A|PARN_uc010uzf.1_Intron|PARN_uc010uzg.1_RNA	NM_002582	NP_002573	O95453	PARN_HUMAN	poly(A)-specific ribonuclease (deadenylation	172					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2						TCAGGAATCGTGACAGGACAT	0.408												
ZNF646	9726	broad.mit.edu	37	16	31087887	31087887	+	Missense_Mutation	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr16:31087887G>A	uc002eap.2	+	2	531	c.242G>A	c.(241-243)GGC>GAC	p.G81D	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	81	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						ACCACCTGTGGCAAGGACTTC	0.627												
NXN	64359	broad.mit.edu	37	17	722696	722696	+	Missense_Mutation	SNP	C	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr17:722696C>T	uc002fsa.2	-	5	895	c.803G>A	c.(802-804)CGG>CAG	p.R268Q	NXN_uc002fsb.1_Missense_Mutation_p.R155Q|NXN_uc010vqd.1_Missense_Mutation_p.R19Q|NXN_uc002frz.2_Missense_Mutation_p.R19Q|NXN_uc010vqe.1_Missense_Mutation_p.R160Q	NM_022463	NP_071908	Q6DKJ4	NXN_HUMAN	nucleoredoxin	268	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			ovary(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		TCCGTACAGCCGGTTGAGGCG	0.607												
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	rs28934576	by1000genomes	TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
KRT9	3857	broad.mit.edu	37	17	39727935	39727935	+	Missense_Mutation	SNP	C	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr17:39727935C>T	uc002hxe.3	-	1	376	c.310G>A	c.(310-312)GGC>AGC	p.G104S	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	104	Head.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				ctactatagcctcctccagaa	0.129												
ABCA9	10350	broad.mit.edu	37	17	67012462	67012462	+	Missense_Mutation	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr17:67012462T>C	uc002jhu.2	-	22	3114	c.2971A>G	c.(2971-2973)AGC>GGC	p.S991G	ABCA9_uc010dez.2_Missense_Mutation_p.S991G	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	991					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					AGTCCATTGCTAATGACATCC	0.348												
RECQL5	9400	broad.mit.edu	37	17	73627684	73627684	+	Missense_Mutation	SNP	C	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr17:73627684C>T	uc010dgl.2	-	9	1450	c.1294G>A	c.(1294-1296)GAC>AAC	p.D432N	RECQL5_uc010dgk.2_Missense_Mutation_p.D405N|RECQL5_uc002jot.3_5'Flank|LOC643008_uc002jow.2_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	432					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TGGCAGTGGTCGCAGCCTTTG	0.701								Other_identified_genes_with_known_or_suspected_DNA_repair_function				
NDUFV2	4729	broad.mit.edu	37	18	9124948	9124948	+	Silent	SNP	C	T	T	rs143576401	byFrequency	TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr18:9124948C>T	uc002knu.2	+	6	613	c.546C>T	c.(544-546)AAC>AAT	p.N182N		NM_021074	NP_066552	P19404	NDUV2_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 2	182					cardiac muscle tissue development|mitochondrial electron transport, NADH to ubiquinone|nervous system development|transport	mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			ovary(1)	1					NADH(DB00157)	CCTGTGTGAACGCACCAATGG	0.313												
GRIN3B	116444	broad.mit.edu	37	19	1004870	1004870	+	Missense_Mutation	SNP	A	G	G			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:1004870A>G	uc002lqo.1	+	3	1370	c.1370A>G	c.(1369-1371)GAC>GGC	p.D457G		NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	457	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GCCACCCTGGACGCACTGTTC	0.672												
PTPRS	5802	broad.mit.edu	37	19	5211663	5211663	+	Silent	SNP	C	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:5211663C>T	uc002mbv.2	-	33	5406	c.5172G>A	c.(5170-5172)CTG>CTA	p.L1724L	PTPRS_uc002mbu.1_Silent_p.L1293L|PTPRS_uc010xin.1_Silent_p.L1266L|PTPRS_uc002mbw.2_Silent_p.L1686L|PTPRS_uc002mbx.2_Silent_p.L1281L|PTPRS_uc002mby.2_Silent_p.L1277L	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1724	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGATGGGTTGCAGACAGACCC	0.552												
C3	718	broad.mit.edu	37	19	6711035	6711035	+	Missense_Mutation	SNP	C	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:6711035C>T	uc002mfm.2	-	12	1504	c.1442G>A	c.(1441-1443)CGC>CAC	p.R481H		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	481					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTCGTGGGCGCGGTCCATTCG	0.607												
PDE4C	5143	broad.mit.edu	37	19	18331288	18331288	+	Silent	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:18331288G>A	uc010xqc.1	-	6	1113	c.633C>T	c.(631-633)GAC>GAT	p.D211D	PDE4C_uc002nik.3_Silent_p.D211D|PDE4C_uc002nil.3_Silent_p.D211D|PDE4C_uc002nif.3_Translation_Start_Site|PDE4C_uc002nig.3_Intron|PDE4C_uc002nih.3_Intron|PDE4C_uc010ebk.2_Silent_p.D105D|PDE4C_uc002nii.3_Silent_p.D179D|PDE4C_uc010ebl.2_Translation_Start_Site|PDE4C_uc010xqd.1_Translation_Start_Site|PDE4C_uc010ebm.1_RNA|PDE4C_uc002nim.1_Nonsense_Mutation_p.R195*	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	211				D -> Y (in Ref. 2; AAD47053/AAD47054).	signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	AGTCCAGCTCGTCTAGCGTCT	0.672												
SBSN	374897	broad.mit.edu	37	19	36017633	36017633	+	Missense_Mutation	SNP	G	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:36017633G>T	uc002oae.1	-	2	592	c.522C>A	c.(520-522)CAC>CAA	p.H174Q	SBSN_uc002oad.1_Missense_Mutation_p.H517Q	NM_198538	NP_940940	Q6UWP8	SBSN_HUMAN	suprabasin isoform 2 precursor	174	Ala/Gly/His-rich.					extracellular region				ovary(1)	1	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CAGCAGCATGGTGGGCACCTT	0.582												
ZNF569	148266	broad.mit.edu	37	19	37904719	37904719	+	Missense_Mutation	SNP	G	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:37904719G>T	uc002ogi.2	-	6	1399	c.841C>A	c.(841-843)CAG>AAG	p.Q281K	ZNF569_uc002ogh.2_Missense_Mutation_p.Q122K|ZNF569_uc002ogj.2_Missense_Mutation_p.Q305K	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	281	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTGATTTCTGGCTGAAGGAC	0.358												
ZNF155	7711	broad.mit.edu	37	19	44500816	44500816	+	Missense_Mutation	SNP	C	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:44500816C>A	uc002oxy.1	+	5	1012	c.807C>A	c.(805-807)TTC>TTA	p.F269L	ZNF155_uc002oxz.1_Missense_Mutation_p.F269L|ZNF155_uc010xwt.1_Missense_Mutation_p.F280L	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	269	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				GGAAGGCCTTCATTCATGATT	0.398												
PNMAL1	55228	broad.mit.edu	37	19	46973358	46973359	+	Missense_Mutation	DNP	CA	AT	AT			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:46973358_46973359CA>AT	uc002peq.3	-	2	1240_1241	c.934_935TG>AT	c.(934-936)TGG>ATG	p.W312M	PNMAL1_uc002per.3_Missense_Mutation_p.W312M	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	312											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GGGACCCTTCCAGGCACATTTC	0.584												
APOB	338	broad.mit.edu	37	2	21230155	21230155	+	Missense_Mutation	SNP	C	G	G	rs141840973		TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr2:21230155C>G	uc002red.2	-	26	9713	c.9585G>C	c.(9583-9585)GAG>GAC	p.E3195D		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3195	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GACTGATAAACTCACAAAGCA	0.323												
APOB	338	broad.mit.edu	37	2	21246441	21246441	+	Missense_Mutation	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr2:21246441T>C	uc002red.2	-	17	2688	c.2560A>G	c.(2560-2562)ATT>GTT	p.I854V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	854					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCGGGAGCAATGACTCCAGAT	0.423												
SPTBN1	6711	broad.mit.edu	37	2	54857158	54857158	+	Silent	SNP	C	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr2:54857158C>A	uc002rxu.2	+	15	3048	c.2799C>A	c.(2797-2799)CTC>CTA	p.L933L	SPTBN1_uc002rxx.2_Silent_p.L920L	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	933	Spectrin 7.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGGACAAACTCAACACAAGGT	0.582												
WDR33	55339	broad.mit.edu	37	2	128471476	128471476	+	Missense_Mutation	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr2:128471476T>C	uc002tpg.1	-	18	3172	c.2989A>G	c.(2989-2991)AGG>GGG	p.R997G		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	997					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GGGGGACCCCTGCAGTCCTGG	0.647												
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	rs121913500		TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 							
COL18A1	80781	broad.mit.edu	37	21	46925140	46925141	+	In_Frame_Ins	INS	-	GGCCCCCCA	GGCCCCCCA			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr21:46925140_46925141insGGCCCCCCA	uc011afs.1	+	35	4218_4219	c.4197_4198insGGCCCCCCA	c.(4195-4200)insGGCCCCCCA	p.1408_1409insGPP	COL18A1_uc002zhg.2_In_Frame_Ins_p.993_994insGPP|COL18A1_uc002zhi.2_In_Frame_Ins_p.1173_1174insGPP|SLC19A1_uc010gpy.1_Intron|COL18A1_uc002zhj.2_5'UTR|COL18A1_uc002zhk.2_5'Flank	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1411_1412	Nonhelical region 10 (NC10).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		AGGGCCCTCCCGGCCCCCCAGG	0.733												
GAS2L1	10634	broad.mit.edu	37	22	29707873	29707873	+	Missense_Mutation	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr22:29707873G>A	uc003afa.1	+	7	1632	c.1433G>A	c.(1432-1434)CGC>CAC	p.R478H	GAS2L1_uc010gvm.1_Intron|GAS2L1_uc003afb.1_3'UTR|GAS2L1_uc003afc.1_Missense_Mutation_p.R478H|GAS2L1_uc003afd.1_Missense_Mutation_p.A478T|GAS2L1_uc003afe.1_Missense_Mutation_p.A478T	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	478					cell cycle arrest	cytoplasm|cytoskeleton					0						CCCCGTGCCCGCAGCCCTGCA	0.711												
EP300	2033	broad.mit.edu	37	22	41564740	41564740	+	Silent	SNP	A	G	G			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr22:41564740A>G	uc003azl.3	+	25	4436	c.4041A>G	c.(4039-4041)GGA>GGG	p.G1347G		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1347					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGGACAGTGGAGAGATGGCAG	0.433			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome			
CHL1	10752	broad.mit.edu	37	3	367748	367748	+	Splice_Site	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:367748G>A	uc003bou.2	+	4	468	c.197_splice	c.e4+1	p.T66_splice	CHL1_uc003bot.2_Splice_Site_p.T66_splice|CHL1_uc003bow.1_Splice_Site_p.T66_splice|CHL1_uc011asi.1_Splice_Site_p.T66_splice	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM						axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAGAACCAACGTGAGTATTGT	0.393												
ATP2B2	491	broad.mit.edu	37	3	10491052	10491052	+	Missense_Mutation	SNP	C	T	T	rs149328739		TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:10491052C>T	uc003bvt.2	-	2	615	c.176G>A	c.(175-177)CGC>CAC	p.R59H	ATP2B2_uc003bvv.2_Missense_Mutation_p.R59H|ATP2B2_uc003bvw.2_Missense_Mutation_p.R59H|ATP2B2_uc010hdp.2_Missense_Mutation_p.R59H	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	59	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding	p.R59C(1)		ovary(3)|skin(2)|central_nervous_system(1)	6						GGTTTTGAGGCGCCGGCAGAT	0.562												
ZNF385D	79750	broad.mit.edu	37	3	21706493	21706493	+	Missense_Mutation	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:21706493G>A	uc003cce.2	-	2	458	c.50C>T	c.(49-51)CCG>CTG	p.P17L	ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	17						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GACAAGGGCCGGGAGAGCAGG	0.517												
TOMM70A	9868	broad.mit.edu	37	3	100105109	100105109	+	Missense_Mutation	SNP	C	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:100105109C>T	uc003dtw.2	-	3	1010	c.578G>A	c.(577-579)CGT>CAT	p.R193H		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	193	Cytoplasmic (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						GGCTTTTGCACGTCTAAAGAG	0.323												
LRRC31	79782	broad.mit.edu	37	3	169572742	169572742	+	Missense_Mutation	SNP	G	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:169572742G>T	uc003fgc.1	-	6	927	c.850C>A	c.(850-852)CTG>ATG	p.L284M	LRRC31_uc010hwp.1_Missense_Mutation_p.L228M	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	284	LRR 3.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			AATTTCCTCAGCTCACCCAAA	0.338												
PLD1	5337	broad.mit.edu	37	3	171426553	171426553	+	Silent	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:171426553T>C	uc003fhs.2	-	11	1253	c.1137A>G	c.(1135-1137)ACA>ACG	p.T379T	PLD1_uc003fht.2_Silent_p.T379T	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	379					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ACCACCAGTCTGTGATAAAAA	0.348												
KCTD8	386617	broad.mit.edu	37	4	44176993	44176993	+	Silent	SNP	G	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr4:44176993G>T	uc003gwu.2	-	2	1520	c.1236C>A	c.(1234-1236)CTC>CTA	p.L412L		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	412						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						GGGTCTGAAAGAGTTCACTGT	0.438										HNSCC(17;0.042)		
ADAMTS3	9508	broad.mit.edu	37	4	73175150	73175150	+	Missense_Mutation	SNP	C	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr4:73175150C>T	uc003hgk.1	-	15	2180	c.2143G>A	c.(2143-2145)GTG>ATG	p.V715M	ADAMTS3_uc003hgl.2_Missense_Mutation_p.V56M	NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	715	Spacer.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTCCCCTTCACGGTTCGGCAG	0.433												
UGT3A2	167127	broad.mit.edu	37	5	36048994	36048994	+	Silent	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr5:36048994T>C	uc003jjz.1	-	4	933	c.840A>G	c.(838-840)CCA>CCG	p.P280P	UGT3A2_uc011cos.1_Silent_p.P246P|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	280	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CACTTACTTGTGGTACTGGTT	0.463												
NNT	23530	broad.mit.edu	37	5	43653189	43653189	+	Missense_Mutation	SNP	C	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr5:43653189C>A	uc003joe.2	+	14	2188	c.1933C>A	c.(1933-1935)CGT>AGT	p.R645S	NNT_uc003jof.2_Missense_Mutation_p.R645S	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	645					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	GGGAACAGCACGTCTTGGCAA	0.542												
GFRAL	389400	broad.mit.edu	37	6	55223736	55223736	+	Missense_Mutation	SNP	A	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr6:55223736A>T	uc003pcm.1	+	6	838	c.752A>T	c.(751-753)AAG>ATG	p.K251M		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	251	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GTGACTAGAAAGTGCCATGAA	0.393												
CCDC146	57639	broad.mit.edu	37	7	76883866	76883866	+	Missense_Mutation	SNP	A	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:76883866A>T	uc003uga.2	+	5	620	c.493A>T	c.(493-495)ATA>TTA	p.I165L		NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	165										ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				ATTTGAGAAGATAACAAAGCC	0.279												
SEMA3C	10512	broad.mit.edu	37	7	80387714	80387714	+	Missense_Mutation	SNP	G	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:80387714G>C	uc003uhj.2	-	15	2138	c.1576C>G	c.(1576-1578)CTG>GTG	p.L526V	SEMA3C_uc011kgw.1_Missense_Mutation_p.L544V	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	526					immune response|response to drug	membrane	receptor activity			ovary(1)	1						TCCCGCGCCAGGCAGCAGTCA	0.522												
PCLO	27445	broad.mit.edu	37	7	82532013	82532013	+	Silent	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:82532013G>A	uc003uhx.2	-	9	13771	c.13482C>T	c.(13480-13482)CAC>CAT	p.H4494H	PCLO_uc003uhv.2_Silent_p.H4494H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4425					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTATCCTTGCGTGAGGAAAGA	0.284												
FIS1	51024	broad.mit.edu	37	7	100884131	100884131	+	Missense_Mutation	SNP	C	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:100884131C>T	uc003uyj.3	-	3	321	c.235G>A	c.(235-237)GTG>ATG	p.V79M	CLDN15_uc003uyh.1_5'Flank|FIS1_uc010lht.2_RNA|FIS1_uc010lhu.2_RNA	NM_016068	NP_057152	Q9Y3D6	FIS1_HUMAN	tetratricopeptide repeat domain 11	79	TPR.|Cytoplasmic (Potential).				apoptosis|mitochondrial fission|peroxisome fission	integral to mitochondrial outer membrane|integral to peroxisomal membrane	protein binding				0	Lung NSC(181;0.168)|all_lung(186;0.215)					TAGTTCCCCACGGCCAGGTAG	0.602												
HIPK2	28996	broad.mit.edu	37	7	139281490	139281490	+	Missense_Mutation	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:139281490T>C	uc003vvf.3	-	12	2864	c.2690A>G	c.(2689-2691)GAG>GGG	p.E897G	HIPK2_uc003vvd.3_Missense_Mutation_p.E870G	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	897	Interaction with TP53 and TP73.|Required for localization to nuclear speckles (By similarity).|Interaction with UBE2I (By similarity).|SUMO interaction motifs (SIM); required for nuclear localization and kinase activity.|Interaction with HMGA1 (By similarity).|Interaction with POU4F1 (By similarity).			DTDEEEE->NFNQQQQ: Loss of SUMO and CBX4 interaction, and impaired nuclear and PML-nuclear bodies localization.	apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					CTGTTCCTCCTCCTCGTCCGT	0.602												
TRPV6	55503	broad.mit.edu	37	7	142571454	142571454	+	Missense_Mutation	SNP	A	G	G			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:142571454A>G	uc003wbx.1	-	13	1751	c.1535T>C	c.(1534-1536)TTC>TCC	p.F512S	TRPV6_uc003wbw.1_Missense_Mutation_p.F298S|TRPV6_uc010lou.1_Missense_Mutation_p.F383S	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	512	Helical; (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CTCTGTCTGGAAGATGATATA	0.597												
SLCO5A1	81796	broad.mit.edu	37	8	70594552	70594552	+	Missense_Mutation	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr8:70594552T>C	uc003xyl.2	-	7	2356	c.1649A>G	c.(1648-1650)AAT>AGT	p.N550S	SLCO5A1_uc010lzb.2_Missense_Mutation_p.N495S|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.N550S	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	550	Extracellular (Potential).|Kazal-like.					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TCCTGTCAGATTCCTATGGGG	0.403												
FBXO43	286151	broad.mit.edu	37	8	101153144	101153144	+	Silent	SNP	T	G	G			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr8:101153144T>G	uc003yjd.2	-	2	2051	c.1338A>C	c.(1336-1338)GTA>GTC	p.V446V	FBXO43_uc003yje.2_Silent_p.V412V|FBXO43_uc010mbp.1_Silent_p.V446V	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	446					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			ACAGCTCATGTACCAATTGCA	0.433												
FZD6	8323	broad.mit.edu	37	8	104337555	104337555	+	Silent	SNP	A	G	G			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr8:104337555A>G	uc003ylh.2	+	4	1505	c.1221A>G	c.(1219-1221)CAA>CAG	p.Q407Q	FZD6_uc003yli.2_Silent_p.Q407Q|FZD6_uc003ylj.2_Silent_p.Q407Q|FZD6_uc011lhn.1_Silent_p.Q373Q|FZD6_uc011lho.1_Silent_p.Q102Q|FZD6_uc011lhp.1_Silent_p.Q352Q	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	407	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			GCCGGAACCAAGAAAAACTAA	0.408												
TTC35	9694	broad.mit.edu	37	8	109468130	109468130	+	Missense_Mutation	SNP	A	G	G			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr8:109468130A>G	uc003ymw.1	+	5	369	c.334A>G	c.(334-336)AGG>GGG	p.R112G		NM_014673	NP_055488	Q15006	TTC35_HUMAN	tetratricopeptide repeat domain 35	112	TPR 1.					endoplasmic reticulum|nucleus	binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.34e-10)			GCTATATGATAGGATTTTACA	0.234												
TAF2	6873	broad.mit.edu	37	8	120744252	120744252	+	Missense_Mutation	SNP	T	C	C			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr8:120744252T>C	uc003you.2	-	26	3782	c.3512A>G	c.(3511-3513)CAT>CGT	p.H1171R		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	1171	Lys-rich.|His-rich.				G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTTACTGTCATGCTTATGCTT	0.458												
SLC35D2	11046	broad.mit.edu	37	9	99084300	99084300	+	Silent	SNP	G	A	A			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr9:99084300G>A	uc004awc.2	-	11	970	c.894C>T	c.(892-894)AAC>AAT	p.N298N	SLC35D2_uc010msd.2_RNA|SLC35D2_uc010mse.2_Silent_p.N251N|SLC35D2_uc010msf.2_Silent_p.N210N|SLC35D2_uc004awd.2_Missense_Mutation_p.L141F	NM_007001	NP_008932	Q76EJ3	S35D2_HUMAN	solute carrier family 35, member D2	298	Helical; (Potential).					Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity				0		Acute lymphoblastic leukemia(62;0.0167)				ACCCTACAAAGTTTAACAAAG	0.343												
RALGDS	5900	broad.mit.edu	37	9	135983521	135983521	+	Missense_Mutation	SNP	G	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr9:135983521G>T	uc004cco.2	-	6	1071	c.1051C>A	c.(1051-1053)CTG>ATG	p.L351M	RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Missense_Mutation_p.L339M|RALGDS_uc004ccr.2_Missense_Mutation_p.L350M|RALGDS_uc011mcv.1_Missense_Mutation_p.L322M|RALGDS_uc004ccs.2_Missense_Mutation_p.L296M|RALGDS_uc011mcw.1_Missense_Mutation_p.L422M|RALGDS_uc004ccv.1_Missense_Mutation_p.L120M|RALGDS_uc004ccu.1_Missense_Mutation_p.L120M	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	351					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		GCTGGCTCCAGCTCTAGAGTT	0.582			T	CIITA	PMBL|Hodgkin Lymphona|							
ATRX	546	broad.mit.edu	37	X	76849273	76849273	+	Frame_Shift_Del	DEL	C	-	-			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chrX:76849273delC	uc004ecp.3	-	26	6235	c.6003delG	c.(6001-6003)TGGfs	p.W2001fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.W1963fs|ATRX_uc004eco.3_Frame_Shift_Del_p.W1786fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2001					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AATCTTTGTACCAGTCTGGAG	0.383			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome					
AFF2	2334	broad.mit.edu	37	X	147733555	147733555	+	Missense_Mutation	SNP	G	T	T			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chrX:147733555G>T	uc004fcp.2	+	2	562	c.83G>T	c.(82-84)AGG>ATG	p.R28M	AFF2_uc004fco.2_Missense_Mutation_p.R28M|AFF2_uc004fcq.2_Missense_Mutation_p.R28M|AFF2_uc004fcr.2_Missense_Mutation_p.R28M|AFF2_uc011mxb.1_Missense_Mutation_p.R28M|AFF2_uc004fcs.2_Missense_Mutation_p.R28M	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	28					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CTTAAAAAAAGGGAATGGGAG	0.363												
