Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
C1orf187	374946	broad.mit.edu	37	1	11779671	11779671	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:11779671A>G	uc001asr.1	+	7	1108	c.968A>G	c.(967-969)AAC>AGC	p.N323S	uc001ass.1_5'Flank	NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor	323					axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		TTCCACCGGAACCGCAGGGTT	0.682000											OREG0013102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	22					0	0	0	0
SLFNL1	200172	broad.mit.edu	37	1	41486124	41486124	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:41486124G>A	uc001cgm.1	-	2	429	c.209C>T	c.(208-210)ACC>ATC	p.T70I	SLFNL1_uc009vwf.1_Missense_Mutation_p.T70I|SLFNL1_uc001cgn.1_Missense_Mutation_p.T70I|SLFNL1_uc009vwg.1_Missense_Mutation_p.T70I	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	70							ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				CCGCTCCAGGGTGTCTCGCAG	0.647000													57	121					0	0	0	0
ZNF687	57592	broad.mit.edu	37	1	151261985	151261985	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:151261985C>T	uc001exq.2	+	5	2701	c.2603C>T	c.(2602-2604)GCC>GTC	p.A868V	ZNF687_uc009wmo.2_Missense_Mutation_p.A868V|ZNF687_uc009wmp.2_Missense_Mutation_p.A868V	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	868	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTGCTCTTTGCCCAAAAAAGG	0.547000													25	47					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237754082	237754082	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:237754082C>T	uc001hyl.1	+	31	4070	c.3950C>T	c.(3949-3951)ACG>ATG	p.T1317M		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1317	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCTCCAAGACGGTGGCTGGA	0.502000													38	67					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237947222	237947222	+	Silent	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:237947222G>A	uc001hyl.1	+	90	12330	c.12210G>A	c.(12208-12210)GCG>GCA	p.A4070A	RYR2_uc010pya.1_Silent_p.A485A	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4070					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTCTTGTGCGGAGACGGATG	0.512000													3	12					0	0	0	0
LOC494141	494141	broad.mit.edu	37	11	18231270	18231270	+	RNA	SNP	C	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr11:18231270C>A	uc009yhh.2	+	2		c.294C>A			LOC494141_uc001mnx.3_RNA|LOC494141_uc009yhi.1_RNA	NR_026541				Homo sapiens cDNA FLJ29025 fis, clone PRS03236.												0						TGGAAAGAGACCACCAATACT	0.318000													5	9					0.000602214	0.000602214	1	0
NAT10	55226	broad.mit.edu	37	11	34139988	34139988	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr11:34139988G>A	uc001mvk.2	+	8	962	c.718G>A	c.(718-720)GAG>AAG	p.E240K	NAT10_uc010ren.1_Missense_Mutation_p.E168K	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	240						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				GGAGTTGAAGGAGAGCTTGCA	0.532000													8	29					0	0	0	0
ACRBP	84519	broad.mit.edu	37	12	6753392	6753392	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr12:6753392G>C	uc001qpu.1	-	5	903	c.855C>G	c.(853-855)ATC>ATG	p.I285M	ACRBP_uc010sfg.1_Missense_Mutation_p.I252M	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	285						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						TGAGCTCCTGGATGTTCTCCA	0.438000													19	82					0	0	0	0
LST-3TM12	338821	broad.mit.edu	37	12	21196320	21196320	+	Silent	SNP	T	C	C			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr12:21196320T>C	uc010sin.1	+	6	639	c.639T>C	c.(637-639)CTT>CTC	p.L213L	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Silent_p.L260L	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	213						membrane	transporter activity				0						CTTGGTGGCTTGGTTTCCTTG	0.363000													23	72					0	0	0	0
MYO16	23026	broad.mit.edu	37	13	109550386	109550386	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr13:109550386T>A	uc001vqt.1	+	15	1742	c.1616T>A	c.(1615-1617)TTT>TAT	p.F539Y	MYO16_uc010agk.1_Missense_Mutation_p.F561Y|MYO16_uc001vqu.1_Missense_Mutation_p.F339Y|MYO16_uc010tjh.1_Missense_Mutation_p.F51Y	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	539	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTAGAAGCCTTTGGACATGCC	0.408000													28	45					0	0	0	0
NF1P1	440225	broad.mit.edu	37	15	21134222	21134222	+	RNA	SNP	G	A	A	rs78711786	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr15:21134222G>A	uc001ytv.1	-	2		c.284C>T								Human NF1-related locus DNA in A9 mouse DNA background.												0						GAACCACACTGGCCAGAGCCA	0.373000													13	60					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	33955106	33955106	+	Missense_Mutation	SNP	A	C	C			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr15:33955106A>C	uc001zhi.2	+	35	5445	c.5375A>C	c.(5374-5376)AAA>ACA	p.K1792T	RYR3_uc010bar.2_Missense_Mutation_p.K1792T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1792	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCTCCTGTCAAAGGCTTGTTG	0.547000													74	105					0	0	0	0
C15orf29	79768	broad.mit.edu	37	15	34434542	34434542	+	Nonstop_Mutation	SNP	A	C	C			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr15:34434542A>C	uc001zhp.2	-	10	1073	c.913T>G	c.(913-915)TGA>GGA	p.*305G		NM_024713	NP_078989	Q9H079	CO029_HUMAN	hypothetical protein LOC79768	305						nucleolus				ovary(1)	1		all_lung(180;1.86e-06)		all cancers(64;5.49e-18)|GBM - Glioblastoma multiforme(113;8.91e-07)|BRCA - Breast invasive adenocarcinoma(123;0.026)|Lung(196;0.229)		GAAATCTCTCAATGTAACTGT	0.284000													6	6					0	0	0	0
SEMA6D	80031	broad.mit.edu	37	15	48056383	48056383	+	Silent	SNP	T	C	C			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr15:48056383T>C	uc010bek.2	+	11	1338	c.978T>C	c.(976-978)TCT>TCC	p.S326S	SEMA6D_uc001zvw.2_Silent_p.S326S|SEMA6D_uc001zvx.1_Silent_p.S326S|SEMA6D_uc001zvy.2_Silent_p.S326S|SEMA6D_uc001zvz.2_Silent_p.S326S|SEMA6D_uc001zwa.2_Silent_p.S326S|SEMA6D_uc001zwb.2_Silent_p.S326S|SEMA6D_uc001zwc.2_Silent_p.S326S	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	326	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TCCCTGGTTCTGCTGTCTGTG	0.448000													27	39					0	0	0	0
Unknown	0	broad.mit.edu	37	16	16468294	16468294	+	Missense_Mutation	SNP	C	T	T	rs147064245	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr16:16468294C>T	uc002dey.2	+	5	1212	c.925C>T	c.(925-927)CGC>TGC	p.R309C						SubName: Full=cDNA FLJ42525 fis, clone BRACE3001391, highly similar to Polycystin;																		AGCCTTCCACCGCAACAGTCT	0.642000													9	31					0	0	0	0
ITPRIPL2	162073	broad.mit.edu	37	16	19126861	19126861	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr16:19126861A>G	uc002dfu.3	+	1	1608	c.1078A>G	c.(1078-1080)AGT>GGT	p.S360G	ITPRIPL2_uc002dft.2_Missense_Mutation_p.S56G	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	360	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						GAAGCTGCTGAGTTGGCTGCA	0.667000													20	56					0	0	0	0
FUS	2521	broad.mit.edu	37	16	31193979	31193979	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr16:31193979C>T	uc002ebf.2	+	3	267	c.184C>T	c.(184-186)CAG>TAG	p.Q62*	FUS_uc002ebe.1_Nonsense_Mutation_p.Q62*|FUS_uc002ebh.2_Nonsense_Mutation_p.Q62*|FUS_uc002ebg.2_5'UTR|FUS_uc002ebi.2_Nonsense_Mutation_p.Q62*|FUS_uc002ebj.2_5'UTR|FUS_uc010vfi.1_Nonsense_Mutation_p.Q62*	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	62	Gln/Gly/Ser/Tyr-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		TGGCCAGAGCCAGAACAGTGA	0.398000			T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								23	74					0	0	0	0
FANCA	2175	broad.mit.edu	37	16	89842188	89842188	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr16:89842188T>C	uc002fou.1	-	21	1904	c.1862A>G	c.(1861-1863)TAC>TGC	p.Y621C	FANCA_uc010vpn.1_Missense_Mutation_p.Y621C	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	621					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GGCCTGGCAGTAGGTGGAGTA	0.458000			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				6	19					0	0	0	0
USP6	9098	broad.mit.edu	37	17	5041493	5041493	+	Missense_Mutation	SNP	G	A	A	rs145087393	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:5041493G>A	uc002gau.1	+	21	3233	c.1003G>A	c.(1003-1005)GAT>AAT	p.D335N	USP6_uc002gav.1_Missense_Mutation_p.D335N|USP6_uc010ckz.1_5'UTR|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	335					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						GGCCATGAACGATGACACCGT	0.577000			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								21	80					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7576852	7576852	+	Splice_Site	SNP	C	T	T	rs11575997		TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:7576852C>T	uc002gim.2	-	9	1187	c.993_splice	c.e9+1	p.Q331_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.Q331_splice|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_Splice_Site_p.Q199_splice|TP53_uc010cng.1_Splice_Site_p.Q199_splice|TP53_uc002gii.1_Splice_Site_p.Q199_splice|TP53_uc010cnh.1_Splice_Site_p.Q331_splice|TP53_uc010cni.1_Splice_Site_p.Q331_splice|TP53_uc002gij.2_Splice_Site_p.Q331_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(16)|p.0?(7)|p.I332fs*49(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGACTTAGTACCTGAAGGGTG	0.458000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	43					0	0	0	0
CDRT15	146822	broad.mit.edu	37	17	14140168	14140168	+	5'Flank	SNP	C	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:14140168C>A	uc010vvu.1	-						CDRT15_uc010coq.2_RNA	NM_001007530	NP_001007531	Q96T59	CDRTF_HUMAN	CMT1A duplicated region transcript 15												0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		TCTTGAGCGACTCCCACCAAG	0.527000													11	24					0.000151284	0.000155319	1	0
NF1	4763	broad.mit.edu	37	17	29685568	29685568	+	Missense_Mutation	SNP	A	G	G	rs146315101		TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:29685568A>G	uc002hgg.2	+	55	8374	c.8041A>G	c.(8041-8043)ATC>GTC	p.I2681V	NF1_uc002hgh.2_Missense_Mutation_p.I2660V|NF1_uc010cso.2_Missense_Mutation_p.I869V|NF1_uc010wbt.1_Missense_Mutation_p.I159V|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2681					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GTTAAATCCAATCCATGGAAT	0.378000			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			9	41					0	0	0	0
SLFN12L	342615	broad.mit.edu	37	17	33806812	33806812	+	Silent	SNP	C	T	T	rs12451876	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:33806812C>T	uc002hjn.2	-	3	1383	c.504G>A	c.(502-504)ACG>ACA	p.T168T		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						TGGAGCTCAACGTGGCAATCT	0.433000													4	8					0	0	0	0
HNF1B	6928	broad.mit.edu	37	17	36104708	36104708	+	Silent	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:36104708G>A	uc002hok.3	-	1	389	c.168C>T	c.(166-168)CCC>CCT	p.P56P	HNF1B_uc010wdi.1_Silent_p.P56P	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	56					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GCTTGGTGTCGGGCTCGGCCC	0.667000									Hereditary_Prostate_Cancer				25	35					0	0	0	0
STARD3	10948	broad.mit.edu	37	17	37814249	37814249	+	Silent	SNP	A	G	G			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr17:37814249A>G	uc002hsd.2	+	5	523	c.399A>G	c.(397-399)GCA>GCG	p.A133A	STARD3_uc010weg.1_Missense_Mutation_p.H129R|STARD3_uc010weh.1_Intron|STARD3_uc002hse.2_Intron|STARD3_uc010wei.1_Missense_Mutation_p.H129R|STARD3_uc002hsf.2_5'UTR|STARD3_uc002hsg.2_5'UTR	NM_006804	NP_006795	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain	133	Helical; (Potential).|MENTAL.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TGTCCAGTGCATTCCTCATTG	0.592000													4	9					0	0	0	0
ALPK2	115701	broad.mit.edu	37	18	56203682	56203682	+	Missense_Mutation	SNP	G	T	T	rs151102442	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr18:56203682G>T	uc002lhj.3	-	5	3951	c.3737C>A	c.(3736-3738)TCT>TAT	p.S1246Y	ALPK2_uc002lhk.1_Missense_Mutation_p.S577Y	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1246							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CCAGATTTCAGAAGCGGAAGC	0.453000													9	42					1.58986e-06	1.65432e-06	1	0
MUC16	94025	broad.mit.edu	37	19	9065802	9065802	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:9065802G>T	uc002mkp.2	-	3	21848	c.21644C>A	c.(21643-21645)ACC>AAC	p.T7215N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7217	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGGGTGGAGGTAATAAACAT	0.483000													40	129					4.65455e-14	4.97778e-14	1	0
ZNF91	7644	broad.mit.edu	37	19	23543330	23543330	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:23543330C>G	uc002nre.2	-	4	2564	c.2451G>C	c.(2449-2451)AAG>AAC	p.K817N	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.K785N	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	817	C2H2-type 24.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TATGAATTGTCTTATGCTTAG	0.408000													9	23					0	0	0	0
DMKN	93099	broad.mit.edu	37	19	36003975	36003975	+	Missense_Mutation	SNP	C	A	A	rs78344601	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:36003975C>A	uc002nzm.3	-	1	586	c.403G>T	c.(403-405)GTG>TTG	p.V135L	DMKN_uc002nzj.2_5'Flank|DMKN_uc002nzk.3_5'Flank|DMKN_uc002nzl.3_5'Flank|DMKN_uc002nzo.3_Missense_Mutation_p.V135L|DMKN_uc002nzn.3_Missense_Mutation_p.V135L|DMKN_uc002nzw.2_5'Flank|DMKN_uc002nzr.2_5'Flank|DMKN_uc002nzp.2_5'Flank|DMKN_uc002nzq.2_5'Flank|DMKN_uc002nzt.2_5'Flank|DMKN_uc002nzs.2_5'Flank|DMKN_uc002nzu.2_5'Flank|DMKN_uc002nzv.2_5'Flank|DMKN_uc010xsv.1_5'Flank|DMKN_uc010xsw.1_5'Flank|DMKN_uc002nzx.3_5'Flank|DMKN_uc002nzy.3_5'Flank|DMKN_uc002nzz.2_5'Flank|DMKN_uc002oac.3_Missense_Mutation_p.V135L|DMKN_uc010eeb.2_Missense_Mutation_p.V135L|DMKN_uc002oaa.3_Missense_Mutation_p.V135L|DMKN_uc002oab.3_Missense_Mutation_p.V135L	NM_033317	NP_201574	Q6E0U4	DMKN_HUMAN	dermokine isoform 2 precursor	135	Gly-rich.					extracellular region				large_intestine(1)|ovary(1)|skin(1)	3	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TGGCCAGGCACCCCCTGCCAG	0.597000													13	67					1.90627e-21	2.09689e-21	1	0
GPR77	27202	broad.mit.edu	37	19	47844786	47844786	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:47844786G>A	uc010ela.1	+	2	948	c.730G>A	c.(730-732)GTC>ATC	p.V244I	GPR77_uc002pgk.1_Missense_Mutation_p.V244I	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	244	Helical; Name=6; (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		GGGGTTTTTTGTCTGCTGGGC	0.706000													14	30					0	0	0	0
ZNF551	90233	broad.mit.edu	37	19	58199337	58199337	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:58199337G>A	uc002qpw.3	+	3	1869	c.1646G>A	c.(1645-1647)GGA>GAA	p.G549E	ZNF551_uc002qpv.3_Missense_Mutation_p.G492E|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	565	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AGTGAATGTGGAAAGTCTTTT	0.453000													9	45					0	0	0	0
SLC5A7	60482	broad.mit.edu	37	2	108622601	108622601	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr2:108622601G>A	uc002tdv.2	+	7	1114	c.838G>A	c.(838-840)GGG>AGG	p.G280R	SLC5A7_uc010ywm.1_Missense_Mutation_p.G33R|SLC5A7_uc010fjj.2_Missense_Mutation_p.G280R|SLC5A7_uc010ywn.1_Missense_Mutation_p.G167R	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	280	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GGCAGCTTTCGGGTGCCTGGT	0.522000													13	77					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	165987867	165987867	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr2:165987867A>G	uc002ucx.2	-	16	2944	c.2452T>C	c.(2452-2454)TAC>CAC	p.Y818H	SCN3A_uc002ucy.2_Missense_Mutation_p.Y769H|SCN3A_uc002ucz.2_Missense_Mutation_p.Y769H|SCN3A_uc002uda.1_Missense_Mutation_p.Y638H|SCN3A_uc002udb.1_Missense_Mutation_p.Y638H	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	818						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TGGAAATAGTAATAAGGATCC	0.398000													22	59					0	0	0	0
SCN1A	6323	broad.mit.edu	37	2	166900348	166900348	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr2:166900348G>A	uc010zcz.1	-	11	1892	c.1874C>T	c.(1873-1875)ACC>ATC	p.T625I	SCN1A_uc002udo.3_Missense_Mutation_p.T494I|SCN1A_uc010fpk.2_Missense_Mutation_p.T494I	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	625						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGACCTACTGGTCTGACTCAG	0.532000													10	33					0	0	0	0
SCN1A	6323	broad.mit.edu	37	2	166911191	166911191	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr2:166911191G>A	uc010zcz.1	-	4	577	c.559C>T	c.(559-561)CGG>TGG	p.R187W	SCN1A_uc002udo.3_Missense_Mutation_p.R56W|SCN1A_uc010fpk.2_Missense_Mutation_p.R56W	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	187	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CATGGATCCCGAAGGAAAGTA	0.353000													7	33					0	0	0	0
PAK7	57144	broad.mit.edu	37	20	9561228	9561228	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr20:9561228A>G	uc002wnl.2	-	5	1099	c.554T>C	c.(553-555)GTG>GCG	p.V185A	PAK7_uc002wnk.2_Missense_Mutation_p.V185A|PAK7_uc002wnj.2_Missense_Mutation_p.V185A|PAK7_uc010gby.1_Missense_Mutation_p.V185A	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	185	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			CAAAGGCTTCACCTCAGAATA	0.463000													15	87					0	0	0	0
IL10RB	3588	broad.mit.edu	37	21	34655489	34655489	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr21:34655489G>T	uc002yrk.1	+	5	688	c.589G>T	c.(589-591)GAT>TAT	p.D197Y	IL10RB_uc002yrh.1_Missense_Mutation_p.D267Y|IL10RB_uc002yri.1_Missense_Mutation_p.D150Y|IL10RB_uc002yrl.1_Missense_Mutation_p.D199Y	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	197	Fibronectin type-III.|Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						GTTTCTTCCTGATCGGAACAA	0.478000													21	40					1.28384e-07	1.35419e-07	1	0
MYH9	4627	broad.mit.edu	37	22	36708210	36708210	+	Missense_Mutation	SNP	T	G	G			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr22:36708210T>G	uc003apg.2	-	14	1843	c.1612A>C	c.(1612-1614)ACC>CCC	p.T538P	MYH9_uc003aph.1_Missense_Mutation_p.T402P	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	538	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CTCTTGTCGGTGGCTTTGGGG	0.602000			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				15	56					0	0	0	0
FAM86D	692099	broad.mit.edu	37	3	75477013	75477013	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr3:75477013G>A	uc003dpp.3	-	5	493	c.134C>T	c.(133-135)TCC>TTC	p.S45F	FAM86D_uc003dpo.3_Intron|FAM86D_uc003dps.3_Intron|FAM86D_uc003dpq.3_5'UTR|FAM86D_uc003dpr.3_Intron	NR_024241				RecName: Full=Protein FAM86B1;												0						GGTACCATGGGAGATGATGGC	0.582000													8	21					0	0	0	0
PPEF2	5470	broad.mit.edu	37	4	76813080	76813080	+	Missense_Mutation	SNP	C	T	T	rs61757739	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr4:76813080C>T	uc003hix.2	-	3	464	c.107G>A	c.(106-108)CGC>CAC	p.R36H	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.R36H	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	36	IQ.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CATCTCCAGGCGGGCCACGTA	0.587000													23	50					0	0	0	0
PTPN13	5783	broad.mit.edu	37	4	87731008	87731008	+	Silent	SNP	T	C	C	rs140778130	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr4:87731008T>C	uc003hpz.2	+	46	7650	c.7170T>C	c.(7168-7170)ACT>ACC	p.T2390T	PTPN13_uc003hpy.2_Silent_p.T2395T|PTPN13_uc003hqa.2_Silent_p.T2371T|PTPN13_uc003hqb.2_Silent_p.T2199T	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2390	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		ATCTGCTTACTTTTATCTCCT	0.463000													9	54					0	0	0	0
EEF1A1P9	441032	broad.mit.edu	37	4	106406417	106406417	+	Missense_Mutation	SNP	T	A	A	rs112715201	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr4:106406417T>A	uc003hxt.1	+	1	555	c.425T>A	c.(424-426)TTT>TAT	p.F142Y		NR_003586				SubName: Full=Eukaryotic translation elongation factor 1 alpha; Flags: Fragment;												0						ACAGTAGCATTTGTGCCAGTT	0.473000													8	36					0	0	0	0
IRX2	153572	broad.mit.edu	37	5	2748946	2748946	+	Silent	SNP	C	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr5:2748946C>T	uc003jda.2	-	3	1118	c.876G>A	c.(874-876)GAG>GAA	p.E292E	IRX2_uc003jdb.2_Silent_p.E292E	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	292						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		GCAGCGGCGCCTCCAAGCCGG	0.537000													3	13					0	0	0	0
HOMER1	9456	broad.mit.edu	37	5	78742906	78742906	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr5:78742906C>G	uc003kfy.2	-	4	1460	c.357G>C	c.(355-357)GAG>GAC	p.E119D	HOMER1_uc010jab.2_Missense_Mutation_p.E119D|HOMER1_uc010jac.2_Intron|HOMER1_uc010jad.2_Intron	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	119					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		GTTCCATCTTCTCTTGTGATT	0.333000													13	27					0	0	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715480	99715480	+	RNA	SNP	C	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr5:99715480C>T	uc011cuw.1	-	4		c.430G>A				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						AAGGTGTTGGCGCCAAGCCAG	0.582000													5	16					0	0	0	0
GEMIN5	25929	broad.mit.edu	37	5	154270961	154270961	+	Missense_Mutation	SNP	G	C	C	rs145603479	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr5:154270961G>C	uc003lvx.3	-	26	4185	c.4102C>G	c.(4102-4104)CAA>GAA	p.Q1368E	GEMIN5_uc011ddk.1_Missense_Mutation_p.Q1367E	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	1368	Potential.				ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGTGAGTTTTGGAGACTGGCA	0.453000													13	72					0	0	0	0
C6orf168	84553	broad.mit.edu	37	6	99729296	99729296	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr6:99729296C>G	uc003ppj.3	-	6	1257	c.974G>C	c.(973-975)AGG>ACG	p.R325T	C6orf168_uc003ppi.3_Missense_Mutation_p.R45T	NM_032511	NP_115900	Q5TGI0	CF168_HUMAN	hypothetical protein LOC84553	325										ovary(2)|central_nervous_system(1)	3		all_cancers(76;1.63e-06)|Acute lymphoblastic leukemia(125;5.12e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00898)|Colorectal(196;0.0699)|Lung NSC(302;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.073)		CCTCCTTATCCTCTCACAGTA	0.483000													61	66					0	0	0	0
KIAA1244	57221	broad.mit.edu	37	6	138584716	138584716	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr6:138584716C>T	uc003qhu.2	+	12	2096	c.2096C>T	c.(2095-2097)GCT>GTT	p.A699V		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	699	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GTGGACACCGCTCTGCAGAAC	0.507000													15	73					0	0	0	0
KBTBD2	25948	broad.mit.edu	37	7	32909544	32909544	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr7:32909544C>T	uc003tdb.2	-	4	1944	c.1285G>A	c.(1285-1287)GAC>AAC	p.D429N	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	429	Kelch 2.										0			GBM - Glioblastoma multiforme(11;0.0499)			TAAATGCAGTCATGAACCACA	0.463000													26	81					0	0	0	0
GPR141	353345	broad.mit.edu	37	7	37780629	37780629	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr7:37780629C>T	uc003tfm.1	+	1	634	c.634C>T	c.(634-636)CGC>TGC	p.R212C	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	212	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						GCAGAAGCTACGCCACTCTTT	0.413000													29	90					0	0	0	0
GLI3	2737	broad.mit.edu	37	7	42262781	42262781	+	Silent	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr7:42262781G>A	uc011kbh.1	-	2	163	c.72C>T	c.(70-72)TCC>TCT	p.S24S		NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	24					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTGTTCGAGTGGAGCACTTCA	0.502000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				35	108					0	0	0	0
ABCB4	5244	broad.mit.edu	37	7	87051439	87051439	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr7:87051439G>A	uc003uiv.1	-	18	2390	c.2314C>T	c.(2314-2316)CAG>TAG	p.Q772*	ABCB4_uc003uiw.1_Nonsense_Mutation_p.Q772*|ABCB4_uc003uix.1_Nonsense_Mutation_p.Q772*	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	772	Helical; (By similarity).|ABC transmembrane type-1 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GTACCTACCTGAAGGAAGAAA	0.323000													7	13					0	0	0	0
SPAM1	6677	broad.mit.edu	37	7	123594394	123594394	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr7:123594394C>T	uc003vld.2	+	4	1172	c.770C>T	c.(769-771)ACT>ATT	p.T257I	SPAM1_uc003vle.2_Missense_Mutation_p.T257I|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.T257I|SPAM1_uc010lku.2_Missense_Mutation_p.T257I	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	257					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	AATGAAAGCACTGCTCTTTAC	0.413000													37	90					0	0	0	0
DLC1	10395	broad.mit.edu	37	8	12952314	12952314	+	Silent	SNP	T	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr8:12952314T>A	uc003wwm.2	-	12	3924	c.3480A>T	c.(3478-3480)CCA>CCT	p.P1160P	DLC1_uc003wwk.1_Silent_p.P723P|DLC1_uc003wwl.1_Silent_p.P757P|DLC1_uc011kxx.1_Silent_p.P649P	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1160	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TCGTCATTAGTGGCTCAGGAA	0.438000													11	38					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110445406	110445406	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr8:110445406T>A	uc003yne.2	+	28	3405	c.3301T>A	c.(3301-3303)TCA>ACA	p.S1101T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1101	Extracellular (Potential).|IPT/TIG 4.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGTAACAGTCTCAGTTGGACC	0.348000										HNSCC(38;0.096)			79	134					0	0	0	0
MTSS1	9788	broad.mit.edu	37	8	125565241	125565241	+	Missense_Mutation	SNP	A	C	C			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr8:125565241A>C	uc003yrk.2	-	14	2794	c.2260T>G	c.(2260-2262)TTT>GTT	p.F754V	NDUFB9_uc011lim.1_Intron|MTSS1_uc003yrh.2_Missense_Mutation_p.F403V|MTSS1_uc011lin.1_Missense_Mutation_p.F528V|MTSS1_uc011lio.1_Missense_Mutation_p.F644V|MTSS1_uc003yri.2_Missense_Mutation_p.F472V|MTSS1_uc003yrj.2_Missense_Mutation_p.F729V|MTSS1_uc003yrl.2_Missense_Mutation_p.F758V	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	754					actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			ACCTAAGAAAAGCGAGGGGCT	0.453000													13	64					0	0	0	0
RASEF	158158	broad.mit.edu	37	9	85615351	85615351	+	Silent	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr9:85615351G>A	uc004amo.1	-	11	1833	c.1572C>T	c.(1570-1572)CCC>CCT	p.P524P		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	524					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						CACCTACCTGGGGCGAGAGTG	0.458000													15	55					0	0	0	0
C9orf47	286223	broad.mit.edu	37	9	91605923	91605923	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr9:91605923T>C	uc004aqd.2	+	1	146	c.13T>C	c.(13-15)TGG>CGG	p.W5R	S1PR3_uc004aqe.2_5'Flank|C9orf47_uc004aqc.1_Missense_Mutation_p.W5R	NM_001001938	NP_001001938	Q6ZRZ4	CI047_HUMAN	hypothetical protein LOC286223 isoform 1	5						extracellular region					0						GGTCAGGATCTGGACAACGAT	0.552000													4	14					0	0	0	0
DBH	1621	broad.mit.edu	37	9	136518097	136518097	+	Silent	SNP	A	G	G	rs77905	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr9:136518097A>G	uc004cel.2	+	9	1419	c.1410A>G	c.(1408-1410)ACA>ACG	p.T470T		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	470	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding	p.T470T(1)		ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CGTACAACACAGAAGACCGGG	0.612000													11	61					0	0	0	0
CDKL5	6792	broad.mit.edu	37	X	18622375	18622375	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:18622375G>A	uc004cym.2	+	12	1584	c.1331G>A	c.(1330-1332)CGC>CAC	p.R444H	CDKL5_uc004cyn.2_Missense_Mutation_p.R444H	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	444			R -> C.		neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					CAGCAGAACCGCCACTCATTC	0.463000													66	112					0	0	0	0
HDAC6	10013	broad.mit.edu	37	X	48672857	48672857	+	Missense_Mutation	SNP	T	G	G			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:48672857T>G	uc011mmi.1	+	11	912	c.817T>G	c.(817-819)TTC>GTC	p.F273V	HDAC6_uc004dks.1_Missense_Mutation_p.F273V|HDAC6_uc010nig.1_Missense_Mutation_p.F121V|HDAC6_uc004dkt.1_Missense_Mutation_p.F273V|HDAC6_uc011mmj.1_Missense_Mutation_p.F218V|HDAC6_uc011mmk.1_Missense_Mutation_p.F254V|HDAC6_uc004dkv.1_Translation_Start_Site|HDAC6_uc004dkw.1_Translation_Start_Site	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	273	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	TGTCCTCTATTTCTCCATCCA	0.532000													74	91					0	0	0	0
GPR173	54328	broad.mit.edu	37	X	53105971	53105971	+	Silent	SNP	T	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:53105971T>A	uc004dru.2	+	2	426	c.168T>A	c.(166-168)GCT>GCA	p.A56A		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	56	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						TGCACAAGGCTCCTTACTACT	0.592000													27	32					0	0	0	0
FAAH2	158584	broad.mit.edu	37	X	57337038	57337038	+	Silent	SNP	G	A	A	rs56161888	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:57337038G>A	uc004dvc.2	+	3	437	c.288G>A	c.(286-288)GCG>GCA	p.A96A		NM_174912	NP_777572	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	96						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3						TTGAGGAAGCGATGAAGGAGG	0.388000										HNSCC(52;0.14)			10	11					0	0	0	0
ZXDB	158586	broad.mit.edu	37	X	57620204	57620204	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:57620204G>T	uc004dvd.2	+	1	1936	c.1723G>T	c.(1723-1725)GGC>TGC	p.G575C		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	575	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						GCATAAGGTGGGCCAGGATCT	0.473000													17	98					2.32416e-17	2.52057e-17	1	0
FAM123B	139285	broad.mit.edu	37	X	63411090	63411090	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:63411090G>A	uc004dvo.2	-	2	2350	c.2077C>T	c.(2077-2079)CCA>TCA	p.P693S		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	693					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CTCCAGTCTGGCTCGCTGCTT	0.562000													5	15					0	0	0	0
CXorf57	55086	broad.mit.edu	37	X	105882883	105882883	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:105882883C>T	uc004emi.3	+	9	1851	c.1700C>T	c.(1699-1701)GCG>GTG	p.A567V	CXorf57_uc004emj.3_Intron	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	567										ovary(1)|lung(1)|breast(1)	3						CATAGCAGTGCGACTGAAAGT	0.418000													37	100					0	0	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507481	74507481	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr1:74507481delA	uc001dfy.3	-	7	1326	c.1134delT	c.(1132-1134)TTTfs	p.F378fs	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	378										ovary(2)	2						GATATGCAGGAAAAAAATGTT	0.348													---	---	---							
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	-	-	rs3812754	byFrequency	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr11:12316384_12316389delCTCCTA	uc001mkg.1	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)CCTCCTACA>CCA	p.PT470del		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	470_471					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		cctcctcctcctcctACAGCGGGAGG	0.432													---	---	---							
GCN1L1	10985	broad.mit.edu	37	12	120595737	120595739	+	In_Frame_Del	DEL	CTC	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr12:120595737_120595739delCTC	uc001txo.2	-	26	3014_3016	c.3001_3003delGAG	c.(3001-3003)GAGdel	p.E1001del		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1001					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGCCATCCACTCCTCCTCCTCC	0.631													---	---	---							
SERPINA12	145264	broad.mit.edu	37	14	94986237	94986245	+	5'Flank	DEL	GGTGGTGAC	-	-	rs147168993	by1000genomes	TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr14:94986237_94986245delGGTGGTGAC	uc001ydj.2	-							NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade						regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		aggtggtgatggtggtgacggaggtggtg	0.072													---	---	---							
Unknown	0	broad.mit.edu	37	14	97602804	97602804	+	IGR	DEL	A	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr14:97602804delA								VRK1 (254854 upstream) : C14orf64 (789143 downstream)																							caccatcaccaccaccaccac	0.010													---	---	---							
Unknown	0	broad.mit.edu	37	15	34781960	34781960	+	IGR	DEL	G	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr15:34781960delG								GOLGA8A (99959 upstream) : GOLGA8B (35525 downstream)																							TAGTGAGGTCGGGGGGGCCCG	0.677													---	---	---							
ARHGEF1	9138	broad.mit.edu	37	19	42400458	42400459	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr19:42400458_42400459insC	uc002orx.2	+	13	1133_1134	c.1024_1025insC	c.(1024-1026)GCCfs	p.A342fs	ARHGEF1_uc002orw.1_Frame_Shift_Ins_p.A342fs|ARHGEF1_uc002ory.2_Frame_Shift_Ins_p.A309fs|ARHGEF1_uc002orz.2_Frame_Shift_Ins_p.A180fs|ARHGEF1_uc002osa.2_Frame_Shift_Ins_p.A357fs|ARHGEF1_uc002osb.2_Frame_Shift_Ins_p.A324fs|ARHGEF1_uc002osc.2_Frame_Shift_Ins_p.A36fs|ARHGEF1_uc002osd.2_5'Flank	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	342					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		AGGTGCTGACGCCCCCCTGGAG	0.688													---	---	---							
C2orf71	388939	broad.mit.edu	37	2	29295647	29295649	+	In_Frame_Del	DEL	TCC	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr2:29295647_29295649delTCC	uc002rmt.1	-	1	1479_1481	c.1479_1481delGGA	c.(1477-1482)GAGGAA>GAA	p.493_494EE>E		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	493_494					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						CATTTTGTCTTCCTCCTCCTCCT	0.542													---	---	---							
Unknown	0	broad.mit.edu	37	20	5261162	5261163	+	IGR	DEL	CT	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr20:5261162_5261163delCT								CDS2 (89175 upstream) : PROKR2 (21524 downstream)																							ttgaatgaaacttatctaacac	0.000													---	---	---							
ZNF217	7764	broad.mit.edu	37	20	52198810	52198810	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr20:52198810delT	uc002xwq.3	-	1	827	c.556delA	c.(556-558)AGCfs	p.S186fs	ZNF217_uc010gij.1_Frame_Shift_Del_p.S178fs	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	186					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			TGCAGTTTGCTTCTGGCCCCC	0.498													---	---	---							
SLC25A1	6576	broad.mit.edu	37	22	19164358	19164358	+	Splice_Site	DEL	C	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr22:19164358delC	uc002zoz.2	-	6	746	c.631_splice	c.e6+1	p.G211_splice	SLC25A1_uc002zoy.2_Splice_Site_p.G108_splice|SLC25A1_uc002zpa.2_Splice_Site_p.G159_splice	NM_005984	NP_005975	P53007	TXTP_HUMAN	solute carrier family 25 (mitochondrial carrier;						gluconeogenesis|long-chain fatty-acyl-CoA biosynthetic process|mitochondrial citrate transport|triglyceride biosynthetic process	integral to membrane|mitochondrial inner membrane	citrate transmembrane transporter activity|protein binding				0	Colorectal(54;0.0993)	all_lung(157;9.94e-09)		Lung(27;0.124)		TGCAGACACACCTCGGTACCA	0.627													---	---	---							
EXOSC7	23016	broad.mit.edu	37	3	45017687	45017688	+	5'Flank	INS	-	GG	GG			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr3:45017687_45017688insGG	uc003coi.2	+						ZDHHC3_uc003cod.2_5'Flank|ZDHHC3_uc003cog.2_5'Flank|ZDHHC3_uc011bad.1_5'Flank|EXOSC7_uc003coh.1_Intron|EXOSC7_uc011bae.1_5'Flank|EXOSC7_uc010his.1_5'Flank|EXOSC7_uc003coj.2_5'Flank	NM_015004	NP_055819	Q15024	EXOS7_HUMAN	exosome component 7						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		TGACGCGGGGCGGGGGGGGGTG	0.767													---	---	---							
FAM194A	131831	broad.mit.edu	37	3	150387211	150387211	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr3:150387211delA	uc003eyg.2	-	12	1428	c.1371delT	c.(1369-1371)ATTfs	p.I457fs	FAM194A_uc003eyh.2_Frame_Shift_Del_p.I311fs	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	457										skin(2)|ovary(1)	3						TGGGCACTCGAATGATGGCTA	0.408													---	---	---							
LOC645323	645323	broad.mit.edu	37	5	87980814	87980816	+	5'Flank	DEL	GAG	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chr5:87980814_87980816delGAG	uc011cua.1	-						LOC645323_uc003kjh.3_5'Flank	NR_015436				Homo sapiens cDNA FLJ34037 fis, clone FCBBF2005439.												0						ggaggaggaagaggaggaggagg	0.409													---	---	---							
MED12	9968	broad.mit.edu	37	X	70348273	70348275	+	In_Frame_Del	DEL	CTC	-	-			TCGA-CQ-7067-01A-11D-2229-08	TCGA-CQ-7067-10A-01D-2229-08									Somatic	Phase_I	Capture				Illumina GAIIx	01f46aa2-e15b-4544-add5-c783868b6c26	e7f351e2-843e-4cb0-9f5e-50aaae26394c	g.chrX:70348273_70348275delCTC	uc004dyy.2	+	23	3536_3538	c.3337_3339delCTC	c.(3337-3339)CTCdel	p.L1114del	MED12_uc011mpq.1_In_Frame_Del_p.L1114del|MED12_uc004dyz.2_In_Frame_Del_p.L1114del|MED12_uc004dza.2_In_Frame_Del_p.L961del|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1114					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TTTCAACGATCTCCTCTGCAATG	0.542													---	---	---							
