Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
AADACL4	343066	broad.mit.edu	37	1	12726525	12726525	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:12726525C>G	uc001auf.2	+	4	1003	c.1003C>G	c.(1003-1005)CAG>GAG	p.Q335E		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	335	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GGTCATCGCTCAGCTTCCTGA	0.517000													10	106					0	0	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12837210	12837210	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:12837210C>G	uc001aui.2	+	3	947	c.920C>G	c.(919-921)TCG>TGG	p.S307W		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	307										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGTCAGAGTCGGACCTGAAG	0.557000													45	127					0	0	0	0
PDPN	10630	broad.mit.edu	37	1	13936917	13936917	+	Silent	SNP	C	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:13936917C>A	uc001avd.2	+	3	514	c.465C>A	c.(463-465)CGC>CGA	p.R155R	PDPN_uc001avc.2_Silent_p.R155R|PDPN_uc009vob.2_Silent_p.R37R|PDPN_uc009voc.2_Silent_p.R37R|PDPN_uc001ave.2_Silent_p.R37R|PDPN_uc001avf.2_Silent_p.R37R	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	79	Extracellular (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		CAGGCATTCGCATCGAGGATC	0.473000													4	66					0.00909568	0.00986433	1	0
PEF1	553115	broad.mit.edu	37	1	32098207	32098207	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:32098207C>T	uc001bth.1	-	4	526	c.514G>A	c.(514-516)GAT>AAT	p.D172N	PEF1_uc001bte.1_Missense_Mutation_p.D11N|PEF1_uc001btf.1_Missense_Mutation_p.D11N|PEF1_uc001btg.1_Missense_Mutation_p.D102N	NM_012392	NP_036524	Q9UBV8	PEF1_HUMAN	penta-EF-hand domain containing 1	172	EF-hand 2.				response to calcium ion	cytoplasm|membrane	calcium ion binding|protein heterodimerization activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)|all_neural(195;0.186)		STAD - Stomach adenocarcinoma(196;0.0546)		CCGTAGACATCGATGCGGCCT	0.557000													14	32					0	0	0	0
SYDE2	84144	broad.mit.edu	37	1	85666170	85666170	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:85666170G>A	uc009wcm.2	-	1	559	c.510C>T	c.(508-510)GGC>GGT	p.G170G	SYDE2_uc001dku.3_Silent_p.G170G	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	170					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		GGTCTCCTTTGCCACTGCGTA	0.642000													31	51					0	0	0	0
DENND2D	79961	broad.mit.edu	37	1	111730992	111730992	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:111730992G>C	uc001eak.1	-	11	1300	c.1100C>G	c.(1099-1101)ACT>AGT	p.T367S	DENND2D_uc001eal.1_Missense_Mutation_p.T364S	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	367										ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		TTGTTCTGCAGCTGCAGGAGA	0.483000													20	44					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	A	A	rs77484671		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:145367767G>A	uc001end.3	+	85	10623	c.10588G>A	c.(10588-10590)GAA>AAA	p.E3530K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3455											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.254000													5	77					0	0	0	0
LINGO4	339398	broad.mit.edu	37	1	151774300	151774300	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:151774300C>T	uc001ezf.1	-	2	1071	c.881G>A	c.(880-882)CGA>CAA	p.R294Q		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	294	Extracellular (Potential).|LRR 9.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCTGAGCCTTCGGGCTGGGAT	0.622000													22	56					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152285104	152285104	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:152285104T>A	uc001ezu.1	-	3	2294	c.2258A>T	c.(2257-2259)CAT>CTT	p.H753L	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	753	Filaggrin 4.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCTTCTGAATGTCCCTCACT	0.582000									Ichthyosis				15	785					0	0	0	0
IQGAP3	128239	broad.mit.edu	37	1	156532415	156532415	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:156532415G>C	uc001fpf.2	-	9	916	c.841C>G	c.(841-843)CAG>GAG	p.Q281E	IQGAP3_uc009wsb.1_Missense_Mutation_p.Q238E	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	281					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATTTCAGCCTGAGTTAGGTAG	0.507000													49	135					0	0	0	0
ATP2B4	493	broad.mit.edu	37	1	203678644	203678644	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:203678644G>C	uc001gzw.2	+	11	2657	c.1773G>C	c.(1771-1773)AAG>AAC	p.K591N	ATP2B4_uc001gzv.2_Missense_Mutation_p.K591N|ATP2B4_uc009xaq.2_Missense_Mutation_p.K591N	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	591	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGTACAGCAAGGGCGCCTCTG	0.557000													7	74					0	0	0	0
OR2L2	26246	broad.mit.edu	37	1	248201955	248201955	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:248201955T>C	uc001idw.2	+	1	482	c.386T>C	c.(385-387)CTC>CCC	p.L129P	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGCTTTCCTCTCCACTATCCC	0.408000													6	179					0	0	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr10:51093329C>T	uc001jif.2	-	8	2011	c.1750G>A	c.(1750-1752)GCA>ACA	p.A584T	PARG_uc001jih.2_Missense_Mutation_p.A584T|PARG_uc001jig.2_Missense_Mutation_p.A170T|PARG_uc010qgv.1_Intron|PARG_uc009xoi.2_Intron|PARG_uc010qgw.1_Missense_Mutation_p.A475T|PARG_uc009xoj.2_Missense_Mutation_p.A135T|PARG_uc010qgx.1_Missense_Mutation_p.A502T	NM_003631	NP_003622	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity			ovary(2)	2				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													4	47					0	0	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687181	68687181	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr10:68687181G>A	uc001jmz.1	+	2	1057	c.507G>A	c.(505-507)CTG>CTA	p.L169L	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Silent_p.L169L	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	169	Extracellular (Potential).|LRR 5.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTAACTCCCTGAGAACCATCC	0.488000													27	90					0	0	0	0
PSAP	5660	broad.mit.edu	37	10	73590951	73590951	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr10:73590951A>C	uc001jsm.2	-	4	411	c.307T>G	c.(307-309)TCT>GCT	p.S103A		NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	103	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						CATGAAGCAGACATGTTCGGT	0.483000													30	62					0	0	0	0
COMTD1	118881	broad.mit.edu	37	10	76993922	76993922	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr10:76993922C>T	uc001jxb.2	-	7	782	c.698G>A	c.(697-699)CGA>CAA	p.R233Q	COMTD1_uc001jxc.1_Silent_p.A324A	NM_144589	NP_653190	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing	233						integral to membrane	O-methyltransferase activity				0	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					GTTTAGGTTTCGCACACACTC	0.682000													23	58					0	0	0	0
LDB3	11155	broad.mit.edu	37	10	88451696	88451696	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr10:88451696G>A	uc001kdv.2	+	5	756	c.733G>A	c.(733-735)GTC>ATC	p.V245I	LDB3_uc010qml.1_Missense_Mutation_p.V245I|LDB3_uc010qmm.1_Missense_Mutation_p.V313I|LDB3_uc001kdu.2_Missense_Mutation_p.V198I|LDB3_uc009xsz.2_Intron|LDB3_uc001kdr.2_Missense_Mutation_p.V198I|LDB3_uc009xsy.2_Missense_Mutation_p.V313I|LDB3_uc001kds.2_Missense_Mutation_p.V245I|LDB3_uc001kdt.2_RNA	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1	245						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						CGCCTCTCCCGTCTACCAGGC	0.602000													6	107					0	0	0	0
MUC6	4588	broad.mit.edu	37	11	1026050	1026050	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:1026050C>G	uc001lsw.2	-	21	2689	c.2638G>C	c.(2638-2640)GAC>CAC	p.D880H		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	880	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGCTGGCCGTCGAAGGTGATG	0.677000													3	7					0	0	0	0
INSC	387755	broad.mit.edu	37	11	15222416	15222416	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:15222416T>G	uc001mly.2	+	7	927	c.881T>G	c.(880-882)TTC>TGC	p.F294C	INSC_uc001mlz.2_Missense_Mutation_p.F247C|INSC_uc001mma.2_Missense_Mutation_p.F247C|INSC_uc010rcs.1_Missense_Mutation_p.F282C|INSC_uc001mmb.2_Missense_Mutation_p.F247C|INSC_uc001mmc.2_Intron	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	294					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CAGGACAGTTTCCGGTGCTTG	0.587000													3	45					0	0	0	0
KCNA4	3739	broad.mit.edu	37	11	30033979	30033979	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:30033979G>C	uc001msk.2	-	2	1399	c.247C>G	c.(247-249)CGG>GGG	p.R83G		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	83						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTCCTCCTCCGACTACCCCGG	0.632000													4	81					0	0	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137416	40137416	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:40137416C>T	uc001mxa.1	-	2	2391	c.427G>A	c.(427-429)GCT>ACT	p.A143T	LRRC4C_uc001mxc.1_Missense_Mutation_p.A139T|LRRC4C_uc001mxd.1_Missense_Mutation_p.A139T|LRRC4C_uc001mxb.1_Missense_Mutation_p.A139T	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	143	LRR 3.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TATACAAAAGCTCCATTCGGG	0.438000													23	53					0	0	0	0
SLC22A12	116085	broad.mit.edu	37	11	64359366	64359366	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:64359366C>T	uc001oam.1	+	1	1085	c.338C>T	c.(337-339)ACG>ATG	p.T113M	SLC22A12_uc009ypr.1_Missense_Mutation_p.T113M|SLC22A12_uc001oal.1_Translation_Start_Site|SLC22A12_uc009yps.1_Missense_Mutation_p.T113M|SLC22A12_uc001oan.1_Missense_Mutation_p.T113M|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	113					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						GAGGCCGACACGGAGCCGTGT	0.672000													18	27					0	0	0	0
ZNF202	7753	broad.mit.edu	37	11	123597653	123597653	+	Silent	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:123597653C>G	uc001pzd.1	-	9	1399	c.999G>C	c.(997-999)CTG>CTC	p.L333L	ZNF202_uc001pzc.1_Silent_p.L109L|ZNF202_uc001pze.1_Silent_p.L333L|ZNF202_uc001pzf.1_Silent_p.L333L	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	333					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CCTCCAAACTCAGATCTTCCT	0.463000													9	226					0	0	0	0
HSN2	378465	broad.mit.edu	37	12	978050	978050	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:978050C>T	uc001qiq.2	+	1	1181	c.1055C>T	c.(1054-1056)TCC>TTC	p.S352F	WNK1_uc001qio.3_Intron|WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_213655	NP_998820			hereditary sensory neuropathy, type II												0	all_cancers(10;0.0107)|all_epithelial(11;0.0151)|Ovarian(42;0.0512)|all_lung(10;0.0521)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.000967)|BRCA - Breast invasive adenocarcinoma(9;0.0178)			TCCAGTGATTCCTCACAAATC	0.488000													6	244					0	0	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20885884	20885884	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:20885884G>T	uc001rej.3	+	11	1583	c.1228G>T	c.(1228-1230)GGG>TGG	p.G410W	SLCO1C1_uc010sii.1_Missense_Mutation_p.G410W|SLCO1C1_uc010sij.1_Missense_Mutation_p.G361W|SLCO1C1_uc009zip.2_Missense_Mutation_p.G244W|SLCO1C1_uc001rei.2_Missense_Mutation_p.G410W|SLCO1C1_uc010sik.1_Missense_Mutation_p.G292W	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	410	Helical; Name=8; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					AATATTCTCTGGGGGGATAGT	0.383000													16	74					3.52763e-06	4.24418e-06	1	0
PPFIBP1	8496	broad.mit.edu	37	12	27824450	27824450	+	Silent	SNP	T	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:27824450T>G	uc001ric.1	+	14	1661	c.1284T>G	c.(1282-1284)ACT>ACG	p.T428T	PPFIBP1_uc010sjr.1_Silent_p.T259T|PPFIBP1_uc001rib.1_Silent_p.T411T|PPFIBP1_uc001ria.2_Silent_p.T397T|PPFIBP1_uc001rid.1_Silent_p.T275T	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	428					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					CAAAGTTGACTCCTAAGCCAG	0.343000													7	71					0	0	0	0
KIF5A	3798	broad.mit.edu	37	12	57975223	57975223	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:57975223C>T	uc001sor.1	+	25	2989	c.2781C>T	c.(2779-2781)TAC>TAT	p.Y927Y	KIF5A_uc010srr.1_Silent_p.Y838Y	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	927	Globular.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						CTGGCCACTACCCAGCATCCT	0.547000													9	72					0	0	0	0
BEST3	144453	broad.mit.edu	37	12	70048856	70048856	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:70048856G>C	uc001svg.2	-	10	2065	c.1838C>G	c.(1837-1839)TCT>TGT	p.S613C	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.S400C|BEST3_uc010stm.1_Missense_Mutation_p.S507C	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	613	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			AGCTGGCTGAGAGCTCATGGG	0.488000													18	32					0	0	0	0
BTBD11	121551	broad.mit.edu	37	12	108006645	108006645	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:108006645A>G	uc001tmk.1	+	6	2419	c.1898A>G	c.(1897-1899)GAG>GGG	p.E633G	BTBD11_uc009zut.1_Missense_Mutation_p.E633G|BTBD11_uc001tmj.2_Missense_Mutation_p.E633G|BTBD11_uc001tml.1_Missense_Mutation_p.E170G	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	633						integral to membrane	DNA binding			skin(2)|ovary(1)	3						CTGAATGTGGAGGTGAGGGTG	0.632000													6	5					0	0	0	0
JPH4	84502	broad.mit.edu	37	14	24040391	24040391	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr14:24040391C>G	uc001wkq.2	-	6	2467	c.1549G>C	c.(1549-1551)GAG>CAG	p.E517Q	JPH4_uc010tnr.1_Missense_Mutation_p.E182Q|JPH4_uc001wkr.2_Missense_Mutation_p.E517Q	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	517	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		ATCCCAGCCTCATCCTCAGCC	0.647000													18	164					0	0	0	0
SERPINA9	327657	broad.mit.edu	37	14	94931144	94931144	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr14:94931144T>C	uc001ydf.2	-	4	1165	c.1004A>G	c.(1003-1005)AAT>AGT	p.N335S	SERPINA9_uc001yde.2_Missense_Mutation_p.N235S|SERPINA9_uc010avc.2_Missense_Mutation_p.N186S|SERPINA9_uc001ydg.2_Missense_Mutation_p.N299S|SERPINA9_uc001ydh.1_Missense_Mutation_p.N335S|SERPINA9_uc001ydi.1_Missense_Mutation_p.N299S	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	317					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GGTTTCCAGATTGTAGGAGGC	0.448000													24	45					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105408273	105408273	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr14:105408273G>T	uc010axc.1	-	7	13635	c.13515C>A	c.(13513-13515)GAC>GAA	p.D4505E	AHNAK2_uc001ypx.2_Missense_Mutation_p.D4405E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4505						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGGTCTTGAGGTCCCCCTGCA	0.612000													7	264					8.12818e-05	9.20397e-05	1	0
JAG2	3714	broad.mit.edu	37	14	105609208	105609208	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr14:105609208C>T	uc001yqg.2	-	26	3945	c.3541G>A	c.(3541-3543)GAG>AAG	p.E1181K	JAG2_uc010axf.2_Silent_p.T4T|JAG2_uc001yqf.2_Missense_Mutation_p.E585K|JAG2_uc001yqh.2_Missense_Mutation_p.E1143K	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	1181	Cytoplasmic (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CCCAGATCCTCGTCCTCCTCA	0.443000													19	13					0	0	0	0
TJP1	7082	broad.mit.edu	37	15	30011211	30011211	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr15:30011211G>A	uc001zcr.2	-	21	3610	c.3135C>T	c.(3133-3135)TAC>TAT	p.Y1045Y	TJP1_uc010azl.2_Silent_p.Y1033Y|TJP1_uc001zcq.2_Silent_p.Y969Y|TJP1_uc001zcs.2_Silent_p.Y965Y	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1045					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GTTTCTCTACGTATGGGAGTT	0.502000													73	172					0	0	0	0
TRPM1	4308	broad.mit.edu	37	15	31294599	31294599	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr15:31294599T>C	uc001zfm.2	-	27	4366	c.4238A>G	c.(4237-4239)TAT>TGT	p.Y1413C	TRPM1_uc010azy.2_Missense_Mutation_p.Y1320C|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1413	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTCCAGGGGATAGGAAATAGT	0.393000													37	74					0	0	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85164140	85164140	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr15:85164140C>T	uc002bkr.2	+	3	940	c.714C>T	c.(712-714)ATC>ATT	p.I238I	ZSCAN2_uc010bmz.1_Silent_p.I236I|ZSCAN2_uc010bna.2_Silent_p.I88I|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	238	C2H2-type 1.				cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		CCCACCTCATCACACACGAGA	0.493000													10	74					0	0	0	0
VPS33B	26276	broad.mit.edu	37	15	91544674	91544674	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr15:91544674A>C	uc002bqp.1	-	19	1778	c.1424T>G	c.(1423-1425)TTC>TGC	p.F475C	VPS33B_uc002bqq.1_Missense_Mutation_p.F384C|VPS33B_uc010uqu.1_Missense_Mutation_p.F448C	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	475					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					CAGAGAACTGAAGGCATCAGT	0.463000													7	65					0	0	0	0
NSMCE1	197370	broad.mit.edu	37	16	27237111	27237111	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:27237111G>A	uc002doi.1	-	7	755	c.657C>T	c.(655-657)TAC>TAT	p.Y219Y	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	219	NSE1-type.				DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0						TCGACTGGAAGTACTTGGCCA	0.612000													20	48					0	0	0	0
MMP2	4313	broad.mit.edu	37	16	55539340	55539340	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:55539340T>C	uc002ehz.3	+	13	2280	c.1969T>C	c.(1969-1971)TGG>CGG	p.W657R	MMP2_uc010vhd.1_Missense_Mutation_p.W581R|MMP2_uc010ccc.2_Missense_Mutation_p.W607R|MMP2_uc002eia.3_Missense_Mutation_p.W154R	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	657	Required for inhibitor TIMP2 binding.|Hemopexin-like 4.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CAAATCCGACTGGCTAGGCTG	0.567000													8	175					0	0	0	0
NOB1	28987	broad.mit.edu	37	16	69782153	69782153	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:69782153C>T	uc002exs.2	-	7	822	c.806G>A	c.(805-807)CGC>CAC	p.R269H		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	269						nucleus	metal ion binding|protein binding				0						GCCATGGCAGCGCAAGATGTA	0.473000													5	41					0	0	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76572217	76572217	+	Missense_Mutation	SNP	C	G	G	rs35153994		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:76572217C>G	uc002feu.1	+	21	3585	c.3200C>G	c.(3199-3201)TCT>TGT	p.S1067C	CNTNAP4_uc002fev.1_Missense_Mutation_p.S931C|CNTNAP4_uc010chb.1_Missense_Mutation_p.S994C|CNTNAP4_uc002fex.1_Missense_Mutation_p.S1070C	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1067	Extracellular (Potential).|Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GAATACCTTTCTGTGATCATT	0.358000													17	125					0	0	0	0
JPH3	57338	broad.mit.edu	37	16	87724057	87724057	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:87724057C>T	uc002fkd.2	+	4	2345	c.2091C>T	c.(2089-2091)TTC>TTT	p.F697F	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	697	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		ACTTGACCTTCTCCCCGCCCC	0.672000													8	6					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578478	7578478	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:7578478G>T	uc002gim.2	-	5	646	c.452C>A	c.(451-453)CCC>CAC	p.P151H	TP53_uc002gig.1_Missense_Mutation_p.P151H|TP53_uc002gih.2_Missense_Mutation_p.P151H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P19H|TP53_uc010cng.1_Missense_Mutation_p.P19H|TP53_uc002gii.1_Missense_Mutation_p.P19H|TP53_uc010cnh.1_Missense_Mutation_p.P151H|TP53_uc010cni.1_Missense_Mutation_p.P151H|TP53_uc002gij.2_Missense_Mutation_p.P151H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P58H|TP53_uc002gio.2_Missense_Mutation_p.P19H|TP53_uc010vug.1_Missense_Mutation_p.P112H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	151	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.P151H(25)|p.P151T(13)|p.P151P(12)|p.P151A(8)|p.0?(7)|p.P151fs*30(7)|p.P151L(6)|p.P151R(6)|p.T150fs*16(3)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P153fs*28(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P152fs*14(1)|p.T150_P151delTP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGGGCGGGGGTGTGGAATC	0.607000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			39	24					4.07013e-28	5.13771e-28	1	0
MYH8	4626	broad.mit.edu	37	17	10298660	10298660	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:10298660C>G	uc002gmm.2	-	34	4847	c.4752G>C	c.(4750-4752)GAG>GAC	p.E1584D	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1584	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GGTCAATTTCCTCATCCTTTT	0.433000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				10	58					0	0	0	0
CCL23	6368	broad.mit.edu	37	17	34340342	34340342	+	Silent	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:34340342G>T	uc002hkt.1	-	4	329	c.258C>A	c.(256-258)CTC>CTA	p.L86L	CCL23_uc002hks.1_Silent_p.L103L	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	86					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	CCTTCTTGGTGAGGAAGCTAG	0.542000													9	15					7.48243e-07	9.07318e-07	1	0
TTC25	83538	broad.mit.edu	37	17	40093075	40093075	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:40093075G>A	uc002hyj.3	+	5	609	c.520G>A	c.(520-522)GAG>AAG	p.E174K	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Missense_Mutation_p.E174K	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	174						cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				CACCAAGGGAGAGCCCAAGTG	0.522000													26	68					0	0	0	0
TBX21	30009	broad.mit.edu	37	17	45820480	45820480	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:45820480G>A	uc002ilv.1	+	3	901	c.690G>A	c.(688-690)GCG>GCA	p.A230A		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	230	T-box.				lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						ACACAGGAGCGCACTGGATGC	0.552000													34	56					0	0	0	0
TUBD1	51174	broad.mit.edu	37	17	57958324	57958324	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:57958324C>T	uc002ixw.1	-	4	746	c.468G>A	c.(466-468)CAG>CAA	p.Q156Q	TUBD1_uc010ddf.1_Silent_p.Q156Q|TUBD1_uc010ddg.1_Silent_p.Q121Q|TUBD1_uc010ddh.1_Silent_p.Q37Q|TUBD1_uc010wok.1_Silent_p.Q156Q|TUBD1_uc002ixx.1_Silent_p.Q156Q|TUBD1_uc010wol.1_Intron|TUBD1_uc010ddi.1_Intron	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	156					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			CTTCTAAATTCTGTGTAACGA	0.383000													21	93					0	0	0	0
CASKIN2	57513	broad.mit.edu	37	17	73498721	73498721	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:73498721C>T	uc002joc.2	-	18	2984	c.2434G>A	c.(2434-2436)GAG>AAG	p.E812K	CASKIN2_uc010wsc.1_Missense_Mutation_p.E730K	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	812	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCTCCCCCTCAGCATCCCCC	0.692000													10	3					0	0	0	0
TMC8	147138	broad.mit.edu	37	17	76134756	76134756	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:76134756G>C	uc002jup.2	+	14	2148	c.1766G>C	c.(1765-1767)CGT>CCT	p.R589P	TMC8_uc002juq.2_Missense_Mutation_p.R366P|TMC8_uc002jur.1_Missense_Mutation_p.V39L	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	589	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			ATTGGCCAGCGTGCCCTCCAC	0.667000									Epidermodysplasia_Verruciformis_Familial_Clustering_of				7	65					0	0	0	0
CBX2	84733	broad.mit.edu	37	17	77753183	77753183	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:77753183G>T	uc002jxc.2	+	3	181	c.139G>T	c.(139-141)GAG>TAG	p.E47*	CBX2_uc002jxb.1_Nonsense_Mutation_p.E47*	NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	47	Chromo.				cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGAGCCGGAGGAGAACATCCT	0.632000													19	12					8.00594e-06	9.55748e-06	1	0
RNF213	57674	broad.mit.edu	37	17	78348328	78348328	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr17:78348328G>A	uc002jyh.1	+	25	7455	c.7232G>A	c.(7231-7233)CGT>CAT	p.R2411H	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.R793H	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AAGGCTCTCCGTGATGCTGTG	0.577000													41	28					0	0	0	0
DSG4	147409	broad.mit.edu	37	18	28968849	28968849	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr18:28968849G>A	uc002kwq.2	+	5	520	c.385G>A	c.(385-387)GCT>ACT	p.A129T	DSG4_uc002kwr.2_Missense_Mutation_p.A129T	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	129	Cadherin 1.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTATTGCCGGGCTCTGAATTC	0.368000													32	71					0	0	0	0
ANGPTL4	51129	broad.mit.edu	37	19	8436124	8436124	+	Splice_Site	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:8436124G>A	uc002mjq.1	+	6	953	c.758_splice	c.e6-1	p.G253_splice	ANGPTL4_uc002mjr.1_Splice_Site_p.G215_splice|ANGPTL4_uc010xkc.1_Splice_Site_p.G86_splice	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor						angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						TCCCACTCCAGGCGAGTTCTG	0.647000													17	39					0	0	0	0
NOTCH3	4854	broad.mit.edu	37	19	15272483	15272483	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:15272483C>A	uc002nan.2	-	33	6032	c.5956G>T	c.(5956-5958)GAG>TAG	p.E1986*		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1986	ANK 5.|Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TTGGCAGCCTCATAGCTGCCC	0.627000													3	13					0.004672	0.00510275	1	0
ZNF626	199777	broad.mit.edu	37	19	20807482	20807482	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:20807482C>A	uc002npb.1	-	4	1351	c.1201G>T	c.(1201-1203)GAA>TAA	p.E401*	ZNF626_uc002npc.1_Nonsense_Mutation_p.E325*	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	401	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTGCCACATTCTTCACATTTG	0.398000													22	70					2.27731e-05	2.67714e-05	1	0
ZNF208	7757	broad.mit.edu	37	19	22154781	22154781	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:22154781G>T	uc002nqp.2	-	6	2820	c.2671C>A	c.(2671-2673)CAT>AAT	p.H891N	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATTTTCTTATGTTCCATAAGG	0.408000													20	62					5.35267e-07	6.54215e-07	1	0
EID2	163126	broad.mit.edu	37	19	40030624	40030624	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:40030624C>T	uc002oma.2	-	1	215	c.96G>A	c.(94-96)CGG>CGA	p.R32R		NM_153232	NP_694964	Q8N6I1	EID2_HUMAN	CREBBP/EP300 inhibitor 2	32					cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding				0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			GGGCCGGCTCCCGCCTCCCGC	0.502000													15	23					0	0	0	0
ZNF574	64763	broad.mit.edu	37	19	42584413	42584413	+	Missense_Mutation	SNP	G	A	A	rs147085110		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:42584413G>A	uc002osm.3	+	2	1824	c.1655G>A	c.(1654-1656)CGG>CAG	p.R552Q	ZNF574_uc002osk.3_Missense_Mutation_p.R642Q	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	552	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CGGCCCTACCGGTGTGGGGAC	0.657000													51	87					0	0	0	0
TMEM145	284339	broad.mit.edu	37	19	42819348	42819348	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:42819348G>A	uc002otk.1	+	7	566	c.514G>A	c.(514-516)GAG>AAG	p.E172K		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	172						integral to membrane					0		Prostate(69;0.00682)				AGGGATCCTGGAGACAGATGT	0.448000													18	40					0	0	0	0
ZNF845	91664	broad.mit.edu	37	19	53855637	53855637	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:53855637A>G	uc010ydv.1	+	4	1826	c.1709A>G	c.(1708-1710)CAA>CGA	p.Q570R	ZNF845_uc010ydw.1_Missense_Mutation_p.Q570R	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	570	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTACCATCAAGCAATCCAT	0.398000													4	41					0	0	0	0
MBOAT7	79143	broad.mit.edu	37	19	54678113	54678113	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:54678113G>A	uc002qdq.2	-	9	1310	c.1044C>T	c.(1042-1044)ACC>ACT	p.T348T	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Silent_p.T32T|MBOAT7_uc010yem.1_Silent_p.T330T|MBOAT7_uc002qdr.2_Silent_p.T348T|MBOAT7_uc002qds.2_Silent_p.T275T|MBOAT7_uc010yen.1_Silent_p.T275T	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	348					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCAGCAGCATGGTCCAGGCGC	0.488000													11	25					0	0	0	0
NLRP13	126204	broad.mit.edu	37	19	56424476	56424476	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:56424476C>T	uc010ygg.1	-	5	732	c.707G>A	c.(706-708)AGG>AAG	p.R236K		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	236	NACHT.|ATP (Potential).						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		AACCCCTGCCCTCCCCACCAA	0.507000													4	130					0	0	0	0
EPAS1	2034	broad.mit.edu	37	2	46605175	46605175	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:46605175C>T	uc002ruv.2	+	10	1880	c.1392C>T	c.(1390-1392)GCC>GCT	p.A464A	EPAS1_uc002ruw.2_5'Flank	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	464					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			AGGCAGCTGCCCCGGGCAGCA	0.682000													3	11					0	0	0	0
CCDC88A	55704	broad.mit.edu	37	2	55528370	55528370	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:55528370A>T	uc002ryv.2	-	28	5555	c.4713T>A	c.(4711-4713)GAT>GAA	p.D1571E	CCDC88A_uc010yoz.1_Missense_Mutation_p.D1544E|CCDC88A_uc010ypa.1_Missense_Mutation_p.D1571E|CCDC88A_uc010fbw.2_Missense_Mutation_p.D100E|CCDC88A_uc002ryu.2_Missense_Mutation_p.D826E|CCDC88A_uc002rys.2_Missense_Mutation_p.D529E|CCDC88A_uc002ryw.2_Missense_Mutation_p.D855E|CCDC88A_uc010fby.1_Missense_Mutation_p.D423E	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1572					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TACTAGAATCATCACTAACAC	0.308000													7	24					0	0	0	0
INPP4A	3631	broad.mit.edu	37	2	99156130	99156130	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:99156130T>A	uc002syy.2	+	10	1203	c.810T>A	c.(808-810)GAT>GAA	p.D270E	INPP4A_uc010yvj.1_Missense_Mutation_p.D270E|INPP4A_uc010yvk.1_Missense_Mutation_p.D270E|INPP4A_uc002syx.2_Missense_Mutation_p.D270E|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	270					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						TAGAGGAAGATGCAGCCAGGT	0.483000													3	46					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	166032739	166032739	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:166032739C>G	uc002ucx.2	-	3	658	c.166G>C	c.(166-168)GAA>CAA	p.E56Q	SCN3A_uc002ucy.2_Missense_Mutation_p.E56Q|SCN3A_uc002ucz.2_Missense_Mutation_p.E56Q	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	56						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTTCCAGCTTCCAAGTCACTA	0.428000													4	119					0	0	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098810	178098810	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:178098810C>G	uc002ulh.3	-	2	790	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63Q|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63Q|NFE2L2_uc002uli.3_Missense_Mutation_p.E63Q|NFE2L2_uc010fra.2_Missense_Mutation_p.E63Q|NFE2L2_uc010frb.2_Missense_Mutation_p.E63Q	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443000			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			20	43					0	0	0	0
ATRN	8455	broad.mit.edu	37	20	3575209	3575209	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:3575209G>A	uc002wim.2	+	20	3496	c.3406G>A	c.(3406-3408)GAG>AAG	p.E1136K	ATRN_uc002wil.2_Missense_Mutation_p.E1136K	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1136	Extracellular (Potential).|Laminin EGF-like 2.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						CAAGGGGGACGAGTGCCAGCT	0.597000													14	57					0	0	0	0
ATRN	8455	broad.mit.edu	37	20	3605205	3605205	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:3605205C>T	uc002wim.2	+	25	3939	c.3849C>T	c.(3847-3849)TTC>TTT	p.F1283F		NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1283	Helical; (Potential).				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						TACAGTTCTTCGTGACTTTCT	0.388000													34	197					0	0	0	0
ASXL1	171023	broad.mit.edu	37	20	31023531	31023531	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:31023531G>T	uc002wxs.2	+	12	3442	c.3016G>T	c.(3016-3018)GAA>TAA	p.E1006*	ASXL1_uc010geb.2_Nonsense_Mutation_p.E897*	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1006					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CTCTGACTTTGAAGGTCACCT	0.502000			F|N|Mis		MDS|CMML								32	53					8.16721e-17	1.02256e-16	1	0
MYH7B	57644	broad.mit.edu	37	20	33589835	33589835	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:33589835G>A	uc002xbi.1	+	42	5979	c.5887G>A	c.(5887-5889)GAA>AAA	p.E1963K		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1921	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGACATGGCGGAAACCCAGGC	0.672000													14	62					0	0	0	0
RALGAPB	57148	broad.mit.edu	37	20	37202933	37202933	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:37202933G>A	uc002xiw.2	+	29	4540	c.4283G>A	c.(4282-4284)CGA>CAA	p.R1428Q	RALGAPB_uc002xix.2_Missense_Mutation_p.R1425Q|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Missense_Mutation_p.R1207Q	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1428					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						GTCAGCAGGCGAGCTCTTGGT	0.358000													9	154					0	0	0	0
OSBPL2	9885	broad.mit.edu	37	20	60835171	60835171	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:60835171C>G	uc002yck.1	+	3	374	c.172C>G	c.(172-174)CAG>GAG	p.Q58E	OSBPL2_uc002ycl.1_Missense_Mutation_p.Q46E|OSBPL2_uc011aah.1_Intron	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	58					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GAACGGAATTCAGAAACACAG	0.453000													18	58					0	0	0	0
SLC17A9	63910	broad.mit.edu	37	20	61594660	61594660	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr20:61594660C>T	uc002yea.3	+	6	848	c.664C>T	c.(664-666)CGG>TGG	p.R222W	SLC17A9_uc002ydz.3_Missense_Mutation_p.R216W|SLC17A9_uc011aap.1_Missense_Mutation_p.R242W	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	222					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						GGCCCAAAGCCGGCCGGTGTC	0.637000													19	42					0	0	0	0
C21orf99	149992	broad.mit.edu	37	21	14414914	14414914	+	RNA	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr21:14414914G>A	uc002yiy.3	+	2		c.351G>A			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						CCTTGATGGCGAAAACAGGAC	0.428000													6	24					0	0	0	0
WDR4	10785	broad.mit.edu	37	21	44299570	44299570	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr21:44299570C>G	uc002zci.2	-	1	109	c.36G>C	c.(34-36)CAG>CAC	p.Q12H	WDR4_uc002zck.1_Missense_Mutation_p.Q12H|WDR4_uc002zcl.1_Intron|WDR4_uc010gpg.1_Missense_Mutation_p.Q12H|WDR4_uc011aew.1_Intron|WDR4_uc010gph.1_5'UTR	NM_033661	NP_387510	P57081	WDR4_HUMAN	WD repeat domain 4 protein	12					tRNA modification	cytoplasm|nucleoplasm	protein binding			ovary(1)	1				Colorectal(79;0.0165)|Lung(125;0.0484)|STAD - Stomach adenocarcinoma(101;0.0624)|COAD - Colon adenocarcinoma(84;0.128)|LUSC - Lung squamous cell carcinoma(216;0.244)		CCACCAACGTCTGCCCGCACA	0.682000													37	60					0	0	0	0
TSSK2	23617	broad.mit.edu	37	22	19118994	19118994	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr22:19118994T>C	uc002zow.2	+	1	674	c.82T>C	c.(82-84)TCT>CCT	p.S28P	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	28	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					AAAAGTCAAATCTGCCTACTC	0.507000													14	34					0	0	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50671941	50671941	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr22:50671941C>T	uc003bkb.1	-	3	1432	c.920G>A	c.(919-921)AGA>AAA	p.R307K	TUBGCP6_uc010har.1_Missense_Mutation_p.R307K|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	307					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGGCTCCTCTCTGTGGCCAGG	0.637000													3	12					0	0	0	0
SBF1	6305	broad.mit.edu	37	22	50897810	50897810	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr22:50897810C>A	uc003blh.2	-	28	3895	c.3700G>T	c.(3700-3702)GCG>TCG	p.A1234S	SBF1_uc011arx.1_Missense_Mutation_p.A898S	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1234	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CTCGAGTCCGCCTGGGACTGG	0.512000													16	18					0.00316338	0.00347972	1	0
GRM7	2917	broad.mit.edu	37	3	6903352	6903352	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:6903352C>T	uc003bqm.2	+	1	551	c.277C>T	c.(277-279)CCC>TCC	p.P93S	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.P93S|GRM7_uc003bql.2_Missense_Mutation_p.P93S	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	93	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CAACAGTGATCCCAACCTACT	0.607000													11	7					0	0	0	0
USP19	10869	broad.mit.edu	37	3	49148936	49148936	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:49148936C>T	uc003cwd.1	-	20	3066	c.2905G>A	c.(2905-2907)GAA>AAA	p.E969K	USP19_uc003cwa.2_Missense_Mutation_p.E777K|USP19_uc003cvz.3_Missense_Mutation_p.E1072K|USP19_uc011bcg.1_Missense_Mutation_p.E1060K|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_Missense_Mutation_p.E727K|USP19_uc011bch.1_Missense_Mutation_p.E1070K	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	969	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATCTTACCTTCGGGTCGGGAC	0.607000													17	17					0	0	0	0
BBX	56987	broad.mit.edu	37	3	107497345	107497345	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:107497345G>T	uc010hpr.2	+	13	2509	c.2182G>T	c.(2182-2184)GAA>TAA	p.E728*	BBX_uc003dwk.3_Nonsense_Mutation_p.E728*|BBX_uc003dwl.3_Missense_Mutation_p.Q391H|BBX_uc003dwm.3_Nonsense_Mutation_p.E728*|BBX_uc003dwo.3_Missense_Mutation_p.Q77H	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	728	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			TGTGTCCTCAGAACCGACTAA	0.438000													5	71					3.59834e-05	4.10477e-05	1	0
PLXND1	23129	broad.mit.edu	37	3	129281955	129281955	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:129281955G>T	uc003emx.2	-	26	4750	c.4650C>A	c.(4648-4650)AAC>AAA	p.N1550K	PLXND1_uc011blb.1_Missense_Mutation_p.N218K	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1550	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGGCCTCGATGTTCTCCCGCA	0.637000													17	23					3.45872e-05	4.00483e-05	1	0
AADAC	13	broad.mit.edu	37	3	151545495	151545495	+	Silent	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:151545495C>G	uc003eze.2	+	5	825	c.735C>G	c.(733-735)CTC>CTG	p.L245L		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	245	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CCAAATCACTCATGGTCAGAT	0.363000													19	58					0	0	0	0
PLCH1	23007	broad.mit.edu	37	3	155200527	155200527	+	Silent	SNP	A	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:155200527A>G	uc011bok.1	-	23	3589	c.3312T>C	c.(3310-3312)GGT>GGC	p.G1104G	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.G1066G	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1104					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGATTTTCACACCATGCAGAT	0.473000													49	170					0	0	0	0
NLGN1	22871	broad.mit.edu	37	3	173997073	173997073	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:173997073G>C	uc003fio.1	+	6	1705	c.1282G>C	c.(1282-1284)GGC>CGC	p.G428R	NLGN1_uc010hww.1_Missense_Mutation_p.G468R|NLGN1_uc003fip.1_Missense_Mutation_p.G428R	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	445	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			ATATCCTGAAGGCAAAGATGT	0.343000													6	90					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	65					0	0	0	0
WDFY3	23001	broad.mit.edu	37	4	85752750	85752750	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr4:85752750C>T	uc003hpd.2	-	8	993	c.585G>A	c.(583-585)GTG>GTA	p.V195V	WDFY3_uc003hpf.2_Silent_p.V195V	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	195						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TGCACAGTTTCactaagatct	0.249000													18	41					0	0	0	0
SLC39A8	64116	broad.mit.edu	37	4	103226195	103226195	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr4:103226195A>T	uc003hwb.1	-	4	1155	c.626T>A	c.(625-627)CTT>CAT	p.L209H	SLC39A8_uc011ceo.1_Missense_Mutation_p.L209H|SLC39A8_uc003hwa.1_Missense_Mutation_p.L142H|SLC39A8_uc003hwc.2_Missense_Mutation_p.L209H	NM_022154	NP_071437	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter),	209	Helical; (Potential).					integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		AAAAAAGAAAAGTAGGTAAAA	0.348000													6	32					0	0	0	0
ARSJ	79642	broad.mit.edu	37	4	114823767	114823767	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr4:114823767G>C	uc003ibq.1	-	2	2351	c.1463C>G	c.(1462-1464)TCA>TGA	p.S488*	ARSJ_uc010imu.1_Nonsense_Mutation_p.S488*|ARSJ_uc010imv.1_Nonsense_Mutation_p.S316*	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	488						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		TTTGCCAGTTGACAAGGTGAT	0.512000													33	61					0	0	0	0
ADAM29	11086	broad.mit.edu	37	4	175897109	175897109	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr4:175897109T>A	uc003iuc.2	+	5	1103	c.433T>A	c.(433-435)TTT>ATT	p.F145I	ADAM29_uc003iud.2_Missense_Mutation_p.F145I|ADAM29_uc010irr.2_Missense_Mutation_p.F145I|ADAM29_uc011cki.1_Missense_Mutation_p.F145I	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	145					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TTCTACCACGTTTGAACATCT	0.383000													16	44					0	0	0	0
TTC23L	153657	broad.mit.edu	37	5	34845770	34845770	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr5:34845770G>A	uc003jiu.2	+	3	350	c.247G>A	c.(247-249)GAA>AAA	p.E83K		NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	83	Potential.						binding			central_nervous_system(1)	1						GCTGATTAAGGAAAAAATGGT	0.358000													3	28					0	0	0	0
PWWP2A	114825	broad.mit.edu	37	5	159520157	159520157	+	Silent	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr5:159520157G>C	uc011ded.1	-	2	1557	c.1500C>G	c.(1498-1500)GGC>GGG	p.G500G	PWWP2A_uc003lxv.3_Silent_p.G500G|PWWP2A_uc011dec.1_Silent_p.G500G	NM_001130864	NP_001124336	Q96N64	PWP2A_HUMAN	PWWP domain containing 2A isoform b	500											0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTGCCATCTTGCCACTCCGCA	0.537000													5	21					0	0	0	0
JARID2	3720	broad.mit.edu	37	6	15501599	15501599	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:15501599G>A	uc003nbj.2	+	8	2651	c.2407G>A	c.(2407-2409)GAC>AAC	p.D803N	JARID2_uc011div.1_Missense_Mutation_p.D631N|JARID2_uc011diw.1_Missense_Mutation_p.D765N	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	803					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGAGGAGGAGGACAAAGGCGT	0.587000													5	27					0	0	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032187	26032187	+	Silent	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:26032187G>T	uc003nfs.1	-	1	102	c.102C>A	c.(100-102)GGC>GGA	p.G34G		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	34					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						TTTTCACGCCGCCGGTAGCCG	0.627000													16	138					4.7546e-09	5.85767e-09	1	0
SCAND3	114821	broad.mit.edu	37	6	28554410	28554410	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:28554410C>T	uc003nlo.2	-	1	703	c.85G>A	c.(85-87)GAA>AAA	p.E29K	uc003nlp.1_5'Flank	NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	29					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGGTCTTCTTCTTTAACCTTT	0.502000													18	45					0	0	0	0
PAQR8	85315	broad.mit.edu	37	6	52268776	52268776	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:52268776C>T	uc003pao.3	+	2	939	c.765C>T	c.(763-765)TTC>TTT	p.F255F		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	255	Helical; Name=5; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					TCCTCTTCTTCCTGGTTAGCG	0.577000													23	52					0	0	0	0
FAM184A	79632	broad.mit.edu	37	6	119341142	119341142	+	Splice_Site	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:119341142C>T	uc003pyj.2	-	4	1680	c.1332_splice	c.e4+1	p.K444_splice	FAM184A_uc003pyk.3_Splice_Site_p.K324_splice|FAM184A_uc003pyl.3_Splice_Site_p.K324_splice	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1											ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TTACTTTTTACCTTCTCCAGT	0.398000													7	60					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129724979	129724979	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:129724979G>T	uc003qbn.2	+	40	5845	c.5740G>T	c.(5740-5742)GCT>TCT	p.A1914S	LAMA2_uc003qbo.2_Missense_Mutation_p.A1914S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1914	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CCTTGATGAGGCTAAAAACAT	0.398000													12	26					2.31682e-05	2.70296e-05	1	0
MAP3K4	4216	broad.mit.edu	37	6	161470492	161470492	+	Missense_Mutation	SNP	G	C	C	rs111941258		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:161470492G>C	uc003qtn.2	+	3	1330	c.1188G>C	c.(1186-1188)TGG>TGC	p.W396C	MAP3K4_uc010kkc.1_Missense_Mutation_p.W396C|MAP3K4_uc003qto.2_Missense_Mutation_p.W396C|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	396					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TCTGTTTGTGGTTAAACATCA	0.403000													10	54					0	0	0	0
MIOS	54468	broad.mit.edu	37	7	7613368	7613368	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:7613368C>T	uc003srf.2	+	4	1570	c.1262C>T	c.(1261-1263)CCA>CTA	p.P421L	MIOS_uc010ktp.1_Missense_Mutation_p.P421L	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	421	WD 6.										0						AATGAAGATCCACAGCTCAAG	0.408000													19	81					0	0	0	0
ADCY1	107	broad.mit.edu	37	7	45725669	45725669	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:45725669C>T	uc003tne.3	+	13	2200	c.2182C>T	c.(2182-2184)CAC>TAC	p.H728Y		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	728	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CGAGTCTACACACCATGCCCT	0.637000													16	61					0	0	0	0
DDC	1644	broad.mit.edu	37	7	50611693	50611693	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:50611693G>T	uc003tpf.3	-	2	177	c.91C>A	c.(91-93)CCT>ACT	p.P31T	DDC_uc010kza.2_Missense_Mutation_p.P31T|DDC_uc003tpg.3_Missense_Mutation_p.P31T	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	31					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	TCCACGTCAGGGTAGACCTGG	0.567000													28	253					1.61788e-16	2.0093e-16	1	0
TYW1B	441250	broad.mit.edu	37	7	72209576	72209576	+	Missense_Mutation	SNP	C	G	G	rs147711959	by1000genomes	TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:72209576C>G	uc011kej.1	-	8	1126	c.967G>C	c.(967-969)GAT>CAT	p.D323H	TYW1B_uc011keh.1_Missense_Mutation_p.D161H|TYW1B_uc011kei.1_5'UTR|TYW1B_uc011kek.1_RNA	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	323					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						CTCGGAGCATCGACTATGACA	0.413000													3	61					0	0	0	0
PDAP1	11333	broad.mit.edu	37	7	99002548	99002548	+	Silent	SNP	C	A	A	rs139029496		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:99002548C>A	uc003uqe.2	-	2	163	c.42G>T	c.(40-42)GCG>GCT	p.A14A		NM_014891	NP_055706	Q13442	HAP28_HUMAN	PDGFA associated protein 1	14					cell proliferation|signal transduction						0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)		Becaplermin(DB00102)	TATACTGCCTCGCCCGGCCTT	0.632000													16	56					0.000422831	0.000468461	1	0
OR2A2	442361	broad.mit.edu	37	7	143806750	143806750	+	Silent	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:143806750C>G	uc011ktz.1	+	1	75	c.75C>G	c.(73-75)CTC>CTG	p.L25L		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	25	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					TGGCGATTCTCCTCTGTGGAC	0.517000													8	168					0	0	0	0
BRF2	55290	broad.mit.edu	37	8	37702008	37702008	+	Nonstop_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr8:37702008T>C	uc003xkk.2	-	4	1370	c.1260A>G	c.(1258-1260)TGA>TGG	p.*420W		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	420					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			TGGATATCCATCAGGGAGGGT	0.488000													15	44					0	0	0	0
KHDRBS3	10656	broad.mit.edu	37	8	136554958	136554958	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr8:136554958A>T	uc003yuv.2	+	3	663	c.269A>T	c.(268-270)GAA>GTA	p.E90V	KHDRBS3_uc003yuw.2_Missense_Mutation_p.E90V	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	90	KH.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			TTACAAGAAGAAACCTTGACA	0.363000													6	63					0	0	0	0
APBA1	320	broad.mit.edu	37	9	72082878	72082878	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:72082878C>T	uc004ahh.2	-	5	1619	c.1343G>A	c.(1342-1344)GGA>GAA	p.G448E		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	448	Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GTCGCAGGGTCCCGGAACTGT	0.557000													65	154					0	0	0	0
Unknown	0	broad.mit.edu	37	9	90746248	90746248	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:90746248C>G	uc011lti.1	-	4	1733	c.1704G>C	c.(1702-1704)GAG>GAC	p.E568D						SubName: Full=cDNA FLJ59639;																		TATGATTCCTCTCTGTGCGTC	0.532000													60	168					0	0	0	0
TNC	3371	broad.mit.edu	37	9	117808854	117808854	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:117808854T>G	uc004bjj.3	-	17	5322	c.4960A>C	c.(4960-4962)ATC>CTC	p.I1654L	TNC_uc010mvf.2_Intron	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1654	Fibronectin type-III 12.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GTATCTCTGATTTTGAGAACA	0.493000													43	135					0	0	0	0
PHF19	26147	broad.mit.edu	37	9	123632758	123632758	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:123632758C>T	uc004bks.1	-	4	580	c.327G>A	c.(325-327)CCG>CCA	p.P109P	PHF19_uc011lyf.1_5'Flank|PHF19_uc004bkr.2_5'Flank|PHF19_uc004bkt.2_Silent_p.P109P|PHF19_uc010mvk.2_Silent_p.P109P	NM_015651	NP_056466	Q5T6S3	PHF19_HUMAN	PHD finger protein 19 isoform a	109	PHD-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|breast(1)	2						TCTCATTCAGCGGCCCTGATG	0.627000													24	183					0	0	0	0
LCN1	3933	broad.mit.edu	37	9	138415134	138415134	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:138415134G>A	uc004cfz.1	+	3	336	c.278G>A	c.(277-279)GGA>GAA	p.G93E	LCN1_uc004cga.1_Missense_Mutation_p.G93E	NM_002297	NP_002288	P31025	LCN1_HUMAN	lipocalin 1 precursor	93					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		GACGAGCCGGGAAAATACACG	0.632000													5	45					0	0	0	0
FRMPD4	9758	broad.mit.edu	37	X	12734834	12734834	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:12734834C>T	uc004cuz.1	+	15	2762	c.2256C>T	c.(2254-2256)GAC>GAT	p.D752D	FRMPD4_uc011mij.1_Silent_p.D744D	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	752					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGGACGAGGACGAGGTGAGCT	0.582000													6	142					0	0	0	0
KDM6A	7403	broad.mit.edu	37	X	44949094	44949094	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:44949094T>A	uc004dge.3	+	25	4030	c.3655T>A	c.(3655-3657)TGG>AGG	p.W1219R	KDM6A_uc011mkz.1_Missense_Mutation_p.W1271R|KDM6A_uc011mla.1_Missense_Mutation_p.W1174R|KDM6A_uc011mlb.1_Missense_Mutation_p.W1226R|KDM6A_uc011mlc.1_Missense_Mutation_p.W923R|KDM6A_uc011mld.1_Missense_Mutation_p.W858R	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1219	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AGATTTGGTCTGGATAAATGC	0.408000			D|N|F|S		renal|oesophageal SCC|MM								7	34					0	0	0	0
CLCN5	1184	broad.mit.edu	37	X	49854987	49854987	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:49854987G>A	uc004dos.1	+	10	1997	c.1749G>A	c.(1747-1749)ATG>ATA	p.M583I	CLCN5_uc004dor.1_Missense_Mutation_p.M653I|CLCN5_uc004doq.1_Missense_Mutation_p.M653I|CLCN5_uc004dot.1_Missense_Mutation_p.M583I	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	583	Cytoplasmic (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					CCCTGGCAATGGATGTGATGA	0.468000													4	65					0	0	0	0
CHIC1	53344	broad.mit.edu	37	X	72797282	72797282	+	Silent	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:72797282C>G	uc004ebk.3	+	2	473	c.336C>G	c.(334-336)TCC>TCG	p.S112S	CHIC1_uc010nlo.2_RNA|CHIC1_uc011mql.1_Silent_p.S112S|CHIC1_uc004ebl.3_Silent_p.S112S	NM_001039840	NP_001034929	Q5VXU3	CHIC1_HUMAN	cysteine-rich hydrophobic domain 1	112						cytoplasmic membrane-bounded vesicle|plasma membrane					0	Renal(35;0.156)					AATTTCCCTCCGTTCTAACAG	0.343000													18	138					0	0	0	0
KLHL4	56062	broad.mit.edu	37	X	86888820	86888820	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:86888820G>A	uc004efb.2	+	8	1803	c.1621G>A	c.(1621-1623)GAA>AAA	p.E541K	KLHL4_uc004efa.2_Missense_Mutation_p.E541K	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	541	Kelch 3.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AAATACTGTAGAAAGATGGGA	0.413000													4	59					0	0	0	0
GPRASP2	114928	broad.mit.edu	37	X	101971267	101971267	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:101971267C>T	uc004ejk.2	+	4	2804	c.1470C>T	c.(1468-1470)ACC>ACT	p.T490T	GPRASP2_uc004ejl.2_Silent_p.T490T|GPRASP2_uc004ejm.2_Silent_p.T490T|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	490						cytoplasm	protein binding			ovary(1)	1						GGCCCCAAACCTGGGACGAGG	0.507000													30	121					0	0	0	0
PRPS1	5631	broad.mit.edu	37	X	106888430	106888430	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:106888430T>C	uc004ene.3	+	5	759	c.554T>C	c.(553-555)CTG>CCG	p.L185P	PRPS1_uc010npg.2_Missense_Mutation_p.L152P|PRPS1_uc011msj.1_5'UTR	NM_002764	NP_002755	P60891	PRPS1_HUMAN	phosphoribosyl pyrophosphate synthetase 1	185					5-phosphoribose 1-diphosphate biosynthetic process|hypoxanthine biosynthetic process|nervous system development|nucleoside metabolic process|purine nucleotide biosynthetic process|pyrimidine nucleotide biosynthetic process|ribonucleoside monophosphate biosynthetic process|urate biosynthetic process	cytosol	ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(3)|large_intestine(1)	4						GCAGACAGGCTGAATGTGGAC	0.438000													9	286					0	0	0	0
IRS4	8471	broad.mit.edu	37	X	107978579	107978579	+	Silent	SNP	A	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:107978579A>G	uc004eoc.2	-	1	1029	c.996T>C	c.(994-996)TGT>TGC	p.C332C		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	332	IRS-type PTB.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						ATTCGTCTGCACACAAGGCTC	0.587000													100	199					0	0	0	0
DCX	1641	broad.mit.edu	37	X	110644290	110644290	+	Silent	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:110644290G>C	uc004epd.2	-	3	1048	c.876C>G	c.(874-876)CTC>CTG	p.L292L	DCX_uc011msv.1_Silent_p.L292L|DCX_uc004epe.2_Silent_p.L211L|DCX_uc004epf.2_Silent_p.L211L|DCX_uc004epg.2_Silent_p.L211L	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	292	Doublecortin 2.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						TGATATCAGTGAGGACTTGCT	0.493000													62	100					0	0	0	0
ALG13	79868	broad.mit.edu	37	X	110979971	110979971	+	Silent	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:110979971T>C	uc011msy.1	+	23	2593	c.2559T>C	c.(2557-2559)GCT>GCC	p.A853A	ALG13_uc011msx.1_Silent_p.A749A|ALG13_uc011msz.1_Silent_p.A775A|ALG13_uc011mta.1_Silent_p.A749A|ALG13_uc011mtb.1_Silent_p.A749A			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	853					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						CAGTTGCAGCTTCCTGTGCCA	0.403000													21	171					0	0	0	0
AKAP14	158798	broad.mit.edu	37	X	119054501	119054501	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:119054501G>T	uc004ese.2	+	7	663	c.525G>T	c.(523-525)TGG>TGT	p.W175C	AKAP14_uc004esf.2_Missense_Mutation_p.W115C	NM_178813	NP_848928	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14 isoform a	175						cytoplasm					0						GAGAAAACTGGCAGAAGAATC	0.338000													19	39					1.15919e-05	1.37319e-05	1	0
CUL4B	8450	broad.mit.edu	37	X	119666336	119666336	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:119666336C>G	uc004esw.2	-	20	2871	c.2434G>C	c.(2434-2436)GAT>CAT	p.D812H	CUL4B_uc010nqq.2_Missense_Mutation_p.D513H|CUL4B_uc004esv.2_Missense_Mutation_p.D794H	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	812					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						TTGAAATCATCATTACAAATG	0.368000													15	45					0	0	0	0
GRIA3	2892	broad.mit.edu	37	X	122459926	122459926	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:122459926G>T	uc004etq.3	+	5	851	c.558G>T	c.(556-558)TGG>TGT	p.W186C	GRIA3_uc004etr.3_Missense_Mutation_p.W186C|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.W170C	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	186	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	AAAACAACTGGCAAGTAACAG	0.418000													15	46					0.000308642	0.000344427	1	0
PLXNA3	55558	broad.mit.edu	37	X	153698126	153698126	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:153698126C>T	uc004flm.2	+	28	4967	c.4794C>T	c.(4792-4794)TAC>TAT	p.Y1598Y		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1598	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCAGCCGCTACGGTAGGTGTC	0.582000													17	49					0	0	0	0
AADACL4	343066	broad.mit.edu	37	1	12726525	12726525	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:12726525C>G	uc001auf.2	+	4	1003	c.1003C>G	c.(1003-1005)CAG>GAG	p.Q335E		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	335	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GGTCATCGCTCAGCTTCCTGA	0.517000													10	106					0	0	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12837210	12837210	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:12837210C>G	uc001aui.2	+	3	947	c.920C>G	c.(919-921)TCG>TGG	p.S307W		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	307										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGTCAGAGTCGGACCTGAAG	0.557000													45	127					0	0	0	0
PDPN	10630	broad.mit.edu	37	1	13936917	13936917	+	Silent	SNP	C	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:13936917C>A	uc001avd.2	+	3	514	c.465C>A	c.(463-465)CGC>CGA	p.R155R	PDPN_uc001avc.2_Silent_p.R155R|PDPN_uc009vob.2_Silent_p.R37R|PDPN_uc009voc.2_Silent_p.R37R|PDPN_uc001ave.2_Silent_p.R37R|PDPN_uc001avf.2_Silent_p.R37R	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	79	Extracellular (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		CAGGCATTCGCATCGAGGATC	0.473000													4	66					0.00909568	0.00980027	1	0
PEF1	553115	broad.mit.edu	37	1	32098207	32098207	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:32098207C>T	uc001bth.1	-	4	526	c.514G>A	c.(514-516)GAT>AAT	p.D172N	PEF1_uc001bte.1_Missense_Mutation_p.D11N|PEF1_uc001btf.1_Missense_Mutation_p.D11N|PEF1_uc001btg.1_Missense_Mutation_p.D102N	NM_012392	NP_036524	Q9UBV8	PEF1_HUMAN	penta-EF-hand domain containing 1	172	EF-hand 2.				response to calcium ion	cytoplasm|membrane	calcium ion binding|protein heterodimerization activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)|all_neural(195;0.186)		STAD - Stomach adenocarcinoma(196;0.0546)		CCGTAGACATCGATGCGGCCT	0.557000													14	32					0	0	0	0
SYDE2	84144	broad.mit.edu	37	1	85666170	85666170	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:85666170G>A	uc009wcm.2	-	1	559	c.510C>T	c.(508-510)GGC>GGT	p.G170G	SYDE2_uc001dku.3_Silent_p.G170G	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	170					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		GGTCTCCTTTGCCACTGCGTA	0.642000													31	51					0	0	0	0
DENND2D	79961	broad.mit.edu	37	1	111730992	111730992	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:111730992G>C	uc001eak.1	-	11	1300	c.1100C>G	c.(1099-1101)ACT>AGT	p.T367S	DENND2D_uc001eal.1_Missense_Mutation_p.T364S	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	367										ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		TTGTTCTGCAGCTGCAGGAGA	0.483000													20	44					0	0	0	0
LINGO4	339398	broad.mit.edu	37	1	151774300	151774300	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:151774300C>T	uc001ezf.1	-	2	1071	c.881G>A	c.(880-882)CGA>CAA	p.R294Q		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	294	Extracellular (Potential).|LRR 9.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCTGAGCCTTCGGGCTGGGAT	0.622000													22	56					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152285104	152285104	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:152285104T>A	uc001ezu.1	-	3	2294	c.2258A>T	c.(2257-2259)CAT>CTT	p.H753L	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	753	Filaggrin 4.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCTTCTGAATGTCCCTCACT	0.582000									Ichthyosis				15	785					0	0	0	0
IQGAP3	128239	broad.mit.edu	37	1	156532415	156532415	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:156532415G>C	uc001fpf.2	-	9	916	c.841C>G	c.(841-843)CAG>GAG	p.Q281E	IQGAP3_uc009wsb.1_Missense_Mutation_p.Q238E	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	281					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATTTCAGCCTGAGTTAGGTAG	0.507000													49	135					0	0	0	0
ATP2B4	493	broad.mit.edu	37	1	203678644	203678644	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:203678644G>C	uc001gzw.2	+	11	2657	c.1773G>C	c.(1771-1773)AAG>AAC	p.K591N	ATP2B4_uc001gzv.2_Missense_Mutation_p.K591N|ATP2B4_uc009xaq.2_Missense_Mutation_p.K591N	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	591	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGTACAGCAAGGGCGCCTCTG	0.557000													7	74					0	0	0	0
OR2L2	26246	broad.mit.edu	37	1	248201955	248201955	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:248201955T>C	uc001idw.2	+	1	482	c.386T>C	c.(385-387)CTC>CCC	p.L129P	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGCTTTCCTCTCCACTATCCC	0.408000													6	179					0	0	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687181	68687181	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr10:68687181G>A	uc001jmz.1	+	2	1057	c.507G>A	c.(505-507)CTG>CTA	p.L169L	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Silent_p.L169L	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	169	Extracellular (Potential).|LRR 5.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTAACTCCCTGAGAACCATCC	0.488000													27	90					0	0	0	0
PSAP	5660	broad.mit.edu	37	10	73590951	73590951	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr10:73590951A>C	uc001jsm.2	-	4	411	c.307T>G	c.(307-309)TCT>GCT	p.S103A		NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	103	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						CATGAAGCAGACATGTTCGGT	0.483000													30	62					0	0	0	0
COMTD1	118881	broad.mit.edu	37	10	76993922	76993922	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr10:76993922C>T	uc001jxb.2	-	7	782	c.698G>A	c.(697-699)CGA>CAA	p.R233Q	COMTD1_uc001jxc.1_Silent_p.A324A	NM_144589	NP_653190	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing	233						integral to membrane	O-methyltransferase activity				0	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					GTTTAGGTTTCGCACACACTC	0.682000													23	58					0	0	0	0
LDB3	11155	broad.mit.edu	37	10	88451696	88451696	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr10:88451696G>A	uc001kdv.2	+	5	756	c.733G>A	c.(733-735)GTC>ATC	p.V245I	LDB3_uc010qml.1_Missense_Mutation_p.V245I|LDB3_uc010qmm.1_Missense_Mutation_p.V313I|LDB3_uc001kdu.2_Missense_Mutation_p.V198I|LDB3_uc009xsz.2_Intron|LDB3_uc001kdr.2_Missense_Mutation_p.V198I|LDB3_uc009xsy.2_Missense_Mutation_p.V313I|LDB3_uc001kds.2_Missense_Mutation_p.V245I|LDB3_uc001kdt.2_RNA	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1	245						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						CGCCTCTCCCGTCTACCAGGC	0.602000													6	107					0	0	0	0
MUC6	4588	broad.mit.edu	37	11	1026050	1026050	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr11:1026050C>G	uc001lsw.2	-	21	2689	c.2638G>C	c.(2638-2640)GAC>CAC	p.D880H		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	880	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGCTGGCCGTCGAAGGTGATG	0.677000													3	7					0	0	0	0
INSC	387755	broad.mit.edu	37	11	15222416	15222416	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr11:15222416T>G	uc001mly.2	+	7	927	c.881T>G	c.(880-882)TTC>TGC	p.F294C	INSC_uc001mlz.2_Missense_Mutation_p.F247C|INSC_uc001mma.2_Missense_Mutation_p.F247C|INSC_uc010rcs.1_Missense_Mutation_p.F282C|INSC_uc001mmb.2_Missense_Mutation_p.F247C|INSC_uc001mmc.2_Intron	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	294					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CAGGACAGTTTCCGGTGCTTG	0.587000													3	45					0	0	0	0
KCNA4	3739	broad.mit.edu	37	11	30033979	30033979	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr11:30033979G>C	uc001msk.2	-	2	1399	c.247C>G	c.(247-249)CGG>GGG	p.R83G		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	83						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTCCTCCTCCGACTACCCCGG	0.632000													4	81					0	0	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137416	40137416	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr11:40137416C>T	uc001mxa.1	-	2	2391	c.427G>A	c.(427-429)GCT>ACT	p.A143T	LRRC4C_uc001mxc.1_Missense_Mutation_p.A139T|LRRC4C_uc001mxd.1_Missense_Mutation_p.A139T|LRRC4C_uc001mxb.1_Missense_Mutation_p.A139T	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	143	LRR 3.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TATACAAAAGCTCCATTCGGG	0.438000													23	53					0	0	0	0
SLC22A12	116085	broad.mit.edu	37	11	64359366	64359366	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr11:64359366C>T	uc001oam.1	+	1	1085	c.338C>T	c.(337-339)ACG>ATG	p.T113M	SLC22A12_uc009ypr.1_Missense_Mutation_p.T113M|SLC22A12_uc001oal.1_Translation_Start_Site|SLC22A12_uc009yps.1_Missense_Mutation_p.T113M|SLC22A12_uc001oan.1_Missense_Mutation_p.T113M|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	113					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						GAGGCCGACACGGAGCCGTGT	0.672000													18	27					0	0	0	0
ZNF202	7753	broad.mit.edu	37	11	123597653	123597653	+	Silent	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr11:123597653C>G	uc001pzd.1	-	9	1399	c.999G>C	c.(997-999)CTG>CTC	p.L333L	ZNF202_uc001pzc.1_Silent_p.L109L|ZNF202_uc001pze.1_Silent_p.L333L|ZNF202_uc001pzf.1_Silent_p.L333L	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	333					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CCTCCAAACTCAGATCTTCCT	0.463000													9	226					0	0	0	0
HSN2	378465	broad.mit.edu	37	12	978050	978050	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr12:978050C>T	uc001qiq.2	+	1	1181	c.1055C>T	c.(1054-1056)TCC>TTC	p.S352F	WNK1_uc001qio.3_Intron|WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_213655	NP_998820			hereditary sensory neuropathy, type II												0	all_cancers(10;0.0107)|all_epithelial(11;0.0151)|Ovarian(42;0.0512)|all_lung(10;0.0521)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.000967)|BRCA - Breast invasive adenocarcinoma(9;0.0178)			TCCAGTGATTCCTCACAAATC	0.488000													6	244					0	0	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20885884	20885884	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr12:20885884G>T	uc001rej.3	+	11	1583	c.1228G>T	c.(1228-1230)GGG>TGG	p.G410W	SLCO1C1_uc010sii.1_Missense_Mutation_p.G410W|SLCO1C1_uc010sij.1_Missense_Mutation_p.G361W|SLCO1C1_uc009zip.2_Missense_Mutation_p.G244W|SLCO1C1_uc001rei.2_Missense_Mutation_p.G410W|SLCO1C1_uc010sik.1_Missense_Mutation_p.G292W	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	410	Helical; Name=8; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					AATATTCTCTGGGGGGATAGT	0.383000													16	74					3.52763e-06	4.18394e-06	1	0
PPFIBP1	8496	broad.mit.edu	37	12	27824450	27824450	+	Silent	SNP	T	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr12:27824450T>G	uc001ric.1	+	14	1661	c.1284T>G	c.(1282-1284)ACT>ACG	p.T428T	PPFIBP1_uc010sjr.1_Silent_p.T259T|PPFIBP1_uc001rib.1_Silent_p.T411T|PPFIBP1_uc001ria.2_Silent_p.T397T|PPFIBP1_uc001rid.1_Silent_p.T275T	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	428					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					CAAAGTTGACTCCTAAGCCAG	0.343000													7	71					0	0	0	0
KIF5A	3798	broad.mit.edu	37	12	57975223	57975223	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr12:57975223C>T	uc001sor.1	+	25	2989	c.2781C>T	c.(2779-2781)TAC>TAT	p.Y927Y	KIF5A_uc010srr.1_Silent_p.Y838Y	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	927	Globular.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						CTGGCCACTACCCAGCATCCT	0.547000													9	72					0	0	0	0
BEST3	144453	broad.mit.edu	37	12	70048856	70048856	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr12:70048856G>C	uc001svg.2	-	10	2065	c.1838C>G	c.(1837-1839)TCT>TGT	p.S613C	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.S400C|BEST3_uc010stm.1_Missense_Mutation_p.S507C	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	613	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			AGCTGGCTGAGAGCTCATGGG	0.488000													18	32					0	0	0	0
BTBD11	121551	broad.mit.edu	37	12	108006645	108006645	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr12:108006645A>G	uc001tmk.1	+	6	2419	c.1898A>G	c.(1897-1899)GAG>GGG	p.E633G	BTBD11_uc009zut.1_Missense_Mutation_p.E633G|BTBD11_uc001tmj.2_Missense_Mutation_p.E633G|BTBD11_uc001tml.1_Missense_Mutation_p.E170G	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	633						integral to membrane	DNA binding			skin(2)|ovary(1)	3						CTGAATGTGGAGGTGAGGGTG	0.632000													6	5					0	0	0	0
JPH4	84502	broad.mit.edu	37	14	24040391	24040391	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr14:24040391C>G	uc001wkq.2	-	6	2467	c.1549G>C	c.(1549-1551)GAG>CAG	p.E517Q	JPH4_uc010tnr.1_Missense_Mutation_p.E182Q|JPH4_uc001wkr.2_Missense_Mutation_p.E517Q	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	517	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		ATCCCAGCCTCATCCTCAGCC	0.647000													18	164					0	0	0	0
SERPINA9	327657	broad.mit.edu	37	14	94931144	94931144	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr14:94931144T>C	uc001ydf.2	-	4	1165	c.1004A>G	c.(1003-1005)AAT>AGT	p.N335S	SERPINA9_uc001yde.2_Missense_Mutation_p.N235S|SERPINA9_uc010avc.2_Missense_Mutation_p.N186S|SERPINA9_uc001ydg.2_Missense_Mutation_p.N299S|SERPINA9_uc001ydh.1_Missense_Mutation_p.N335S|SERPINA9_uc001ydi.1_Missense_Mutation_p.N299S	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	317					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GGTTTCCAGATTGTAGGAGGC	0.448000													24	45					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105408273	105408273	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr14:105408273G>T	uc010axc.1	-	7	13635	c.13515C>A	c.(13513-13515)GAC>GAA	p.D4505E	AHNAK2_uc001ypx.2_Missense_Mutation_p.D4405E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4505						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGGTCTTGAGGTCCCCCTGCA	0.612000													7	264					8.12818e-05	9.07746e-05	1	0
TJP1	7082	broad.mit.edu	37	15	30011211	30011211	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr15:30011211G>A	uc001zcr.2	-	21	3610	c.3135C>T	c.(3133-3135)TAC>TAT	p.Y1045Y	TJP1_uc010azl.2_Silent_p.Y1033Y|TJP1_uc001zcq.2_Silent_p.Y969Y|TJP1_uc001zcs.2_Silent_p.Y965Y	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1045					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GTTTCTCTACGTATGGGAGTT	0.502000													73	172					0	0	0	0
TRPM1	4308	broad.mit.edu	37	15	31294599	31294599	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr15:31294599T>C	uc001zfm.2	-	27	4366	c.4238A>G	c.(4237-4239)TAT>TGT	p.Y1413C	TRPM1_uc010azy.2_Missense_Mutation_p.Y1320C|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1413	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTCCAGGGGATAGGAAATAGT	0.393000													37	74					0	0	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85164140	85164140	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr15:85164140C>T	uc002bkr.2	+	3	940	c.714C>T	c.(712-714)ATC>ATT	p.I238I	ZSCAN2_uc010bmz.1_Silent_p.I236I|ZSCAN2_uc010bna.2_Silent_p.I88I|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	238	C2H2-type 1.				cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		CCCACCTCATCACACACGAGA	0.493000													10	74					0	0	0	0
VPS33B	26276	broad.mit.edu	37	15	91544674	91544674	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr15:91544674A>C	uc002bqp.1	-	19	1778	c.1424T>G	c.(1423-1425)TTC>TGC	p.F475C	VPS33B_uc002bqq.1_Missense_Mutation_p.F384C|VPS33B_uc010uqu.1_Missense_Mutation_p.F448C	NM_018668	NP_061138	Q9H267	VP33B_HUMAN	vacuolar protein sorting 33B (yeast homolog))	475					cellular membrane fusion|lysosome localization|melanosome localization|platelet alpha granule organization|protein transport|vesicle docking involved in exocytosis	late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm|platelet alpha granule	protein binding			ovary(2)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					CAGAGAACTGAAGGCATCAGT	0.463000													7	65					0	0	0	0
NSMCE1	197370	broad.mit.edu	37	16	27237111	27237111	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr16:27237111G>A	uc002doi.1	-	7	755	c.657C>T	c.(655-657)TAC>TAT	p.Y219Y	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	219	NSE1-type.				DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0						TCGACTGGAAGTACTTGGCCA	0.612000													20	48					0	0	0	0
MMP2	4313	broad.mit.edu	37	16	55539340	55539340	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr16:55539340T>C	uc002ehz.3	+	13	2280	c.1969T>C	c.(1969-1971)TGG>CGG	p.W657R	MMP2_uc010vhd.1_Missense_Mutation_p.W581R|MMP2_uc010ccc.2_Missense_Mutation_p.W607R|MMP2_uc002eia.3_Missense_Mutation_p.W154R	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	657	Required for inhibitor TIMP2 binding.|Hemopexin-like 4.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CAAATCCGACTGGCTAGGCTG	0.567000													8	175					0	0	0	0
NOB1	28987	broad.mit.edu	37	16	69782153	69782153	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr16:69782153C>T	uc002exs.2	-	7	822	c.806G>A	c.(805-807)CGC>CAC	p.R269H		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	269						nucleus	metal ion binding|protein binding				0						GCCATGGCAGCGCAAGATGTA	0.473000													5	41					0	0	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76572217	76572217	+	Missense_Mutation	SNP	C	G	G	rs35153994		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr16:76572217C>G	uc002feu.1	+	21	3585	c.3200C>G	c.(3199-3201)TCT>TGT	p.S1067C	CNTNAP4_uc002fev.1_Missense_Mutation_p.S931C|CNTNAP4_uc010chb.1_Missense_Mutation_p.S994C|CNTNAP4_uc002fex.1_Missense_Mutation_p.S1070C	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1067	Extracellular (Potential).|Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GAATACCTTTCTGTGATCATT	0.358000													17	125					0	0	0	0
JPH3	57338	broad.mit.edu	37	16	87724057	87724057	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr16:87724057C>T	uc002fkd.2	+	4	2345	c.2091C>T	c.(2089-2091)TTC>TTT	p.F697F	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	697	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		ACTTGACCTTCTCCCCGCCCC	0.672000													8	6					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578478	7578478	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr17:7578478G>T	uc002gim.2	-	5	646	c.452C>A	c.(451-453)CCC>CAC	p.P151H	TP53_uc002gig.1_Missense_Mutation_p.P151H|TP53_uc002gih.2_Missense_Mutation_p.P151H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P19H|TP53_uc010cng.1_Missense_Mutation_p.P19H|TP53_uc002gii.1_Missense_Mutation_p.P19H|TP53_uc010cnh.1_Missense_Mutation_p.P151H|TP53_uc010cni.1_Missense_Mutation_p.P151H|TP53_uc002gij.2_Missense_Mutation_p.P151H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P58H|TP53_uc002gio.2_Missense_Mutation_p.P19H|TP53_uc010vug.1_Missense_Mutation_p.P112H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	151	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.P151H(25)|p.P151T(13)|p.P151P(12)|p.P151A(8)|p.0?(7)|p.P151fs*30(7)|p.P151L(6)|p.P151R(6)|p.T150fs*16(3)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P153fs*28(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P152fs*14(1)|p.T150_P151delTP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGGGCGGGGGTGTGGAATC	0.607000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			39	24					4.07013e-28	5.06284e-28	1	0
MYH8	4626	broad.mit.edu	37	17	10298660	10298660	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr17:10298660C>G	uc002gmm.2	-	34	4847	c.4752G>C	c.(4750-4752)GAG>GAC	p.E1584D	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1584	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GGTCAATTTCCTCATCCTTTT	0.433000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				10	58					0	0	0	0
CCL23	6368	broad.mit.edu	37	17	34340342	34340342	+	Silent	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr17:34340342G>T	uc002hkt.1	-	4	329	c.258C>A	c.(256-258)CTC>CTA	p.L86L	CCL23_uc002hks.1_Silent_p.L103L	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	86					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	CCTTCTTGGTGAGGAAGCTAG	0.542000													9	15					7.48243e-07	8.94384e-07	1	0
TTC25	83538	broad.mit.edu	37	17	40093075	40093075	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr17:40093075G>A	uc002hyj.3	+	5	609	c.520G>A	c.(520-522)GAG>AAG	p.E174K	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Missense_Mutation_p.E174K	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	174						cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				CACCAAGGGAGAGCCCAAGTG	0.522000													26	68					0	0	0	0
TBX21	30009	broad.mit.edu	37	17	45820480	45820480	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr17:45820480G>A	uc002ilv.1	+	3	901	c.690G>A	c.(688-690)GCG>GCA	p.A230A		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	230	T-box.				lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						ACACAGGAGCGCACTGGATGC	0.552000													34	56					0	0	0	0
TUBD1	51174	broad.mit.edu	37	17	57958324	57958324	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr17:57958324C>T	uc002ixw.1	-	4	746	c.468G>A	c.(466-468)CAG>CAA	p.Q156Q	TUBD1_uc010ddf.1_Silent_p.Q156Q|TUBD1_uc010ddg.1_Silent_p.Q121Q|TUBD1_uc010ddh.1_Silent_p.Q37Q|TUBD1_uc010wok.1_Silent_p.Q156Q|TUBD1_uc002ixx.1_Silent_p.Q156Q|TUBD1_uc010wol.1_Intron|TUBD1_uc010ddi.1_Intron	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	156					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			CTTCTAAATTCTGTGTAACGA	0.383000													21	93					0	0	0	0
CASKIN2	57513	broad.mit.edu	37	17	73498721	73498721	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr17:73498721C>T	uc002joc.2	-	18	2984	c.2434G>A	c.(2434-2436)GAG>AAG	p.E812K	CASKIN2_uc010wsc.1_Missense_Mutation_p.E730K	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	812	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCTCCCCCTCAGCATCCCCC	0.692000													10	3					0	0	0	0
TMC8	147138	broad.mit.edu	37	17	76134756	76134756	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr17:76134756G>C	uc002jup.2	+	14	2148	c.1766G>C	c.(1765-1767)CGT>CCT	p.R589P	TMC8_uc002juq.2_Missense_Mutation_p.R366P|TMC8_uc002jur.1_Missense_Mutation_p.V39L	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	589	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			ATTGGCCAGCGTGCCCTCCAC	0.667000									Epidermodysplasia_Verruciformis_Familial_Clustering_of				7	65					0	0	0	0
CBX2	84733	broad.mit.edu	37	17	77753183	77753183	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr17:77753183G>T	uc002jxc.2	+	3	181	c.139G>T	c.(139-141)GAG>TAG	p.E47*	CBX2_uc002jxb.1_Nonsense_Mutation_p.E47*	NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	47	Chromo.				cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGAGCCGGAGGAGAACATCCT	0.632000													19	12					8.00594e-06	9.42238e-06	1	0
RNF213	57674	broad.mit.edu	37	17	78348328	78348328	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr17:78348328G>A	uc002jyh.1	+	25	7455	c.7232G>A	c.(7231-7233)CGT>CAT	p.R2411H	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.R793H	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AAGGCTCTCCGTGATGCTGTG	0.577000													41	28					0	0	0	0
DSG4	147409	broad.mit.edu	37	18	28968849	28968849	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr18:28968849G>A	uc002kwq.2	+	5	520	c.385G>A	c.(385-387)GCT>ACT	p.A129T	DSG4_uc002kwr.2_Missense_Mutation_p.A129T	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	129	Cadherin 1.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTATTGCCGGGCTCTGAATTC	0.368000													32	71					0	0	0	0
ANGPTL4	51129	broad.mit.edu	37	19	8436124	8436124	+	Splice_Site	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:8436124G>A	uc002mjq.1	+	6	953	c.758_splice	c.e6-1	p.G253_splice	ANGPTL4_uc002mjr.1_Splice_Site_p.G215_splice|ANGPTL4_uc010xkc.1_Splice_Site_p.G86_splice	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor						angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						TCCCACTCCAGGCGAGTTCTG	0.647000													17	39					0	0	0	0
NOTCH3	4854	broad.mit.edu	37	19	15272483	15272483	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:15272483C>A	uc002nan.2	-	33	6032	c.5956G>T	c.(5956-5958)GAG>TAG	p.E1986*		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1986	ANK 5.|Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TTGGCAGCCTCATAGCTGCCC	0.627000													3	13					0.004672	0.00506962	1	0
ZNF626	199777	broad.mit.edu	37	19	20807482	20807482	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:20807482C>A	uc002npb.1	-	4	1351	c.1201G>T	c.(1201-1203)GAA>TAA	p.E401*	ZNF626_uc002npc.1_Nonsense_Mutation_p.E325*	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	401	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTGCCACATTCTTCACATTTG	0.398000													22	70					2.27731e-05	2.6396e-05	1	0
ZNF208	7757	broad.mit.edu	37	19	22154781	22154781	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:22154781G>T	uc002nqp.2	-	6	2820	c.2671C>A	c.(2671-2673)CAT>AAT	p.H891N	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATTTTCTTATGTTCCATAAGG	0.408000													20	62					5.35267e-07	6.44849e-07	1	0
EID2	163126	broad.mit.edu	37	19	40030624	40030624	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:40030624C>T	uc002oma.2	-	1	215	c.96G>A	c.(94-96)CGG>CGA	p.R32R		NM_153232	NP_694964	Q8N6I1	EID2_HUMAN	CREBBP/EP300 inhibitor 2	32					cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding				0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			GGGCCGGCTCCCGCCTCCCGC	0.502000													15	23					0	0	0	0
ZNF574	64763	broad.mit.edu	37	19	42584413	42584413	+	Missense_Mutation	SNP	G	A	A	rs147085110		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:42584413G>A	uc002osm.3	+	2	1824	c.1655G>A	c.(1654-1656)CGG>CAG	p.R552Q	ZNF574_uc002osk.3_Missense_Mutation_p.R642Q	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	552	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CGGCCCTACCGGTGTGGGGAC	0.657000													51	87					0	0	0	0
TMEM145	284339	broad.mit.edu	37	19	42819348	42819348	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:42819348G>A	uc002otk.1	+	7	566	c.514G>A	c.(514-516)GAG>AAG	p.E172K		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	172						integral to membrane					0		Prostate(69;0.00682)				AGGGATCCTGGAGACAGATGT	0.448000													18	40					0	0	0	0
ZNF845	91664	broad.mit.edu	37	19	53855637	53855637	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:53855637A>G	uc010ydv.1	+	4	1826	c.1709A>G	c.(1708-1710)CAA>CGA	p.Q570R	ZNF845_uc010ydw.1_Missense_Mutation_p.Q570R	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	570	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTACCATCAAGCAATCCAT	0.398000													4	41					0	0	0	0
MBOAT7	79143	broad.mit.edu	37	19	54678113	54678113	+	Silent	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:54678113G>A	uc002qdq.2	-	9	1310	c.1044C>T	c.(1042-1044)ACC>ACT	p.T348T	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Silent_p.T32T|MBOAT7_uc010yem.1_Silent_p.T330T|MBOAT7_uc002qdr.2_Silent_p.T348T|MBOAT7_uc002qds.2_Silent_p.T275T|MBOAT7_uc010yen.1_Silent_p.T275T	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	348					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCAGCAGCATGGTCCAGGCGC	0.488000													11	25					0	0	0	0
NLRP13	126204	broad.mit.edu	37	19	56424476	56424476	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:56424476C>T	uc010ygg.1	-	5	732	c.707G>A	c.(706-708)AGG>AAG	p.R236K		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	236	NACHT.|ATP (Potential).						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		AACCCCTGCCCTCCCCACCAA	0.507000													4	130					0	0	0	0
EPAS1	2034	broad.mit.edu	37	2	46605175	46605175	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr2:46605175C>T	uc002ruv.2	+	10	1880	c.1392C>T	c.(1390-1392)GCC>GCT	p.A464A	EPAS1_uc002ruw.2_5'Flank	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	464					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			AGGCAGCTGCCCCGGGCAGCA	0.682000													3	11					0	0	0	0
CCDC88A	55704	broad.mit.edu	37	2	55528370	55528370	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr2:55528370A>T	uc002ryv.2	-	28	5555	c.4713T>A	c.(4711-4713)GAT>GAA	p.D1571E	CCDC88A_uc010yoz.1_Missense_Mutation_p.D1544E|CCDC88A_uc010ypa.1_Missense_Mutation_p.D1571E|CCDC88A_uc010fbw.2_Missense_Mutation_p.D100E|CCDC88A_uc002ryu.2_Missense_Mutation_p.D826E|CCDC88A_uc002rys.2_Missense_Mutation_p.D529E|CCDC88A_uc002ryw.2_Missense_Mutation_p.D855E|CCDC88A_uc010fby.1_Missense_Mutation_p.D423E	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1572					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TACTAGAATCATCACTAACAC	0.308000													7	24					0	0	0	0
INPP4A	3631	broad.mit.edu	37	2	99156130	99156130	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr2:99156130T>A	uc002syy.2	+	10	1203	c.810T>A	c.(808-810)GAT>GAA	p.D270E	INPP4A_uc010yvj.1_Missense_Mutation_p.D270E|INPP4A_uc010yvk.1_Missense_Mutation_p.D270E|INPP4A_uc002syx.2_Missense_Mutation_p.D270E|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	270					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						TAGAGGAAGATGCAGCCAGGT	0.483000													3	46					0	0	0	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr2:114355998C>G	uc002tkh.2	+	5	674	c.616C>G	c.(616-618)CAC>GAC	p.H206D	WASH2P_uc002tka.2_RNA|WASH2P_uc002tkb.2_RNA|WASH2P_uc002tkd.2_RNA	NM_182905	NP_878908			WAS protein family homolog 1												0						CCAAGGTGGGCACTTGATGTC	0.612000													3	12					0	0	0	0
DDX11L2	84771	broad.mit.edu	37	2	114357557	114357557	+	Nonstop_Mutation	SNP	A	G	G	rs115341812	by1000genomes	TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr2:114357557A>G	uc010yxx.1	-	3	709	c.382T>C	c.(382-384)TAG>CAG	p.*128Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						GCCTACTTCTAGTGAAACTGG	0.567000													3	26					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	166032739	166032739	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr2:166032739C>G	uc002ucx.2	-	3	658	c.166G>C	c.(166-168)GAA>CAA	p.E56Q	SCN3A_uc002ucy.2_Missense_Mutation_p.E56Q|SCN3A_uc002ucz.2_Missense_Mutation_p.E56Q	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	56						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTTCCAGCTTCCAAGTCACTA	0.428000													4	119					0	0	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098810	178098810	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr2:178098810C>G	uc002ulh.3	-	2	790	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63Q|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63Q|NFE2L2_uc002uli.3_Missense_Mutation_p.E63Q|NFE2L2_uc010fra.2_Missense_Mutation_p.E63Q|NFE2L2_uc010frb.2_Missense_Mutation_p.E63Q	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443000			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			20	43					0	0	0	0
ATRN	8455	broad.mit.edu	37	20	3575209	3575209	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr20:3575209G>A	uc002wim.2	+	20	3496	c.3406G>A	c.(3406-3408)GAG>AAG	p.E1136K	ATRN_uc002wil.2_Missense_Mutation_p.E1136K	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1136	Extracellular (Potential).|Laminin EGF-like 2.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						CAAGGGGGACGAGTGCCAGCT	0.597000													14	57					0	0	0	0
ATRN	8455	broad.mit.edu	37	20	3605205	3605205	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr20:3605205C>T	uc002wim.2	+	25	3939	c.3849C>T	c.(3847-3849)TTC>TTT	p.F1283F		NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1283	Helical; (Potential).				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						TACAGTTCTTCGTGACTTTCT	0.388000													34	197					0	0	0	0
ASXL1	171023	broad.mit.edu	37	20	31023531	31023531	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr20:31023531G>T	uc002wxs.2	+	12	3442	c.3016G>T	c.(3016-3018)GAA>TAA	p.E1006*	ASXL1_uc010geb.2_Nonsense_Mutation_p.E897*	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1006					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CTCTGACTTTGAAGGTCACCT	0.502000			F|N|Mis		MDS|CMML								32	53					8.16721e-17	1.00773e-16	1	0
MYH7B	57644	broad.mit.edu	37	20	33589835	33589835	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr20:33589835G>A	uc002xbi.1	+	42	5979	c.5887G>A	c.(5887-5889)GAA>AAA	p.E1963K		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1921	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGACATGGCGGAAACCCAGGC	0.672000													14	62					0	0	0	0
RALGAPB	57148	broad.mit.edu	37	20	37202933	37202933	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr20:37202933G>A	uc002xiw.2	+	29	4540	c.4283G>A	c.(4282-4284)CGA>CAA	p.R1428Q	RALGAPB_uc002xix.2_Missense_Mutation_p.R1425Q|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Missense_Mutation_p.R1207Q	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1428					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						GTCAGCAGGCGAGCTCTTGGT	0.358000													9	154					0	0	0	0
OSBPL2	9885	broad.mit.edu	37	20	60835171	60835171	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr20:60835171C>G	uc002yck.1	+	3	374	c.172C>G	c.(172-174)CAG>GAG	p.Q58E	OSBPL2_uc002ycl.1_Missense_Mutation_p.Q46E|OSBPL2_uc011aah.1_Intron	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	58					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GAACGGAATTCAGAAACACAG	0.453000													18	58					0	0	0	0
SLC17A9	63910	broad.mit.edu	37	20	61594660	61594660	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr20:61594660C>T	uc002yea.3	+	6	848	c.664C>T	c.(664-666)CGG>TGG	p.R222W	SLC17A9_uc002ydz.3_Missense_Mutation_p.R216W|SLC17A9_uc011aap.1_Missense_Mutation_p.R242W	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	222					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						GGCCCAAAGCCGGCCGGTGTC	0.637000													19	42					0	0	0	0
C21orf99	149992	broad.mit.edu	37	21	14414914	14414914	+	RNA	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr21:14414914G>A	uc002yiy.3	+	2		c.351G>A			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						CCTTGATGGCGAAAACAGGAC	0.428000													6	24					0	0	0	0
WDR4	10785	broad.mit.edu	37	21	44299570	44299570	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr21:44299570C>G	uc002zci.2	-	1	109	c.36G>C	c.(34-36)CAG>CAC	p.Q12H	WDR4_uc002zck.1_Missense_Mutation_p.Q12H|WDR4_uc002zcl.1_Intron|WDR4_uc010gpg.1_Missense_Mutation_p.Q12H|WDR4_uc011aew.1_Intron|WDR4_uc010gph.1_5'UTR	NM_033661	NP_387510	P57081	WDR4_HUMAN	WD repeat domain 4 protein	12					tRNA modification	cytoplasm|nucleoplasm	protein binding			ovary(1)	1				Colorectal(79;0.0165)|Lung(125;0.0484)|STAD - Stomach adenocarcinoma(101;0.0624)|COAD - Colon adenocarcinoma(84;0.128)|LUSC - Lung squamous cell carcinoma(216;0.244)		CCACCAACGTCTGCCCGCACA	0.682000													37	60					0	0	0	0
TSSK2	23617	broad.mit.edu	37	22	19118994	19118994	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr22:19118994T>C	uc002zow.2	+	1	674	c.82T>C	c.(82-84)TCT>CCT	p.S28P	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	28	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					AAAAGTCAAATCTGCCTACTC	0.507000													14	34					0	0	0	0
RANGAP1	5905	broad.mit.edu	37	22	41652800	41652800	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr22:41652800A>C	uc003azs.2	-	7	2273	c.803T>G	c.(802-804)GTG>GGG	p.V268G	RANGAP1_uc003azt.2_Missense_Mutation_p.V268G|RANGAP1_uc003azu.2_Missense_Mutation_p.V268G|RANGAP1_uc011aoz.1_Missense_Mutation_p.V213G	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	268					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						AAAATTAATCACCTCCACCTG	0.637000													6	11					0	0	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50671941	50671941	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr22:50671941C>T	uc003bkb.1	-	3	1432	c.920G>A	c.(919-921)AGA>AAA	p.R307K	TUBGCP6_uc010har.1_Missense_Mutation_p.R307K|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	307					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGGCTCCTCTCTGTGGCCAGG	0.637000													3	12					0	0	0	0
SBF1	6305	broad.mit.edu	37	22	50897810	50897810	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr22:50897810C>A	uc003blh.2	-	28	3895	c.3700G>T	c.(3700-3702)GCG>TCG	p.A1234S	SBF1_uc011arx.1_Missense_Mutation_p.A898S	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1234	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CTCGAGTCCGCCTGGGACTGG	0.512000													16	18					0.00316338	0.00345712	1	0
GRM7	2917	broad.mit.edu	37	3	6903352	6903352	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr3:6903352C>T	uc003bqm.2	+	1	551	c.277C>T	c.(277-279)CCC>TCC	p.P93S	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.P93S|GRM7_uc003bql.2_Missense_Mutation_p.P93S	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	93	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CAACAGTGATCCCAACCTACT	0.607000													11	7					0	0	0	0
USP19	10869	broad.mit.edu	37	3	49148936	49148936	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr3:49148936C>T	uc003cwd.1	-	20	3066	c.2905G>A	c.(2905-2907)GAA>AAA	p.E969K	USP19_uc003cwa.2_Missense_Mutation_p.E777K|USP19_uc003cvz.3_Missense_Mutation_p.E1072K|USP19_uc011bcg.1_Missense_Mutation_p.E1060K|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_Missense_Mutation_p.E727K|USP19_uc011bch.1_Missense_Mutation_p.E1070K	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	969	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATCTTACCTTCGGGTCGGGAC	0.607000													17	17					0	0	0	0
BBX	56987	broad.mit.edu	37	3	107497345	107497345	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr3:107497345G>T	uc010hpr.2	+	13	2509	c.2182G>T	c.(2182-2184)GAA>TAA	p.E728*	BBX_uc003dwk.3_Nonsense_Mutation_p.E728*|BBX_uc003dwl.3_Missense_Mutation_p.Q391H|BBX_uc003dwm.3_Nonsense_Mutation_p.E728*|BBX_uc003dwo.3_Missense_Mutation_p.Q77H	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	728	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			TGTGTCCTCAGAACCGACTAA	0.438000													5	71					3.59834e-05	4.04813e-05	1	0
ADCY5	111	broad.mit.edu	37	3	123167254	123167254	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr3:123167254C>G	uc003egh.1	-	1	139	c.139G>C	c.(139-141)GGG>CGG	p.G47R		NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	47	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GCAGAGCCCCCGGGGGCATGG	0.632000													5	7					0	0	0	0
PLXND1	23129	broad.mit.edu	37	3	129281955	129281955	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr3:129281955G>T	uc003emx.2	-	26	4750	c.4650C>A	c.(4648-4650)AAC>AAA	p.N1550K	PLXND1_uc011blb.1_Missense_Mutation_p.N218K	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1550	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGGCCTCGATGTTCTCCCGCA	0.637000													17	23					3.45872e-05	3.94913e-05	1	0
AADAC	13	broad.mit.edu	37	3	151545495	151545495	+	Silent	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr3:151545495C>G	uc003eze.2	+	5	825	c.735C>G	c.(733-735)CTC>CTG	p.L245L		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	245	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CCAAATCACTCATGGTCAGAT	0.363000													19	58					0	0	0	0
PLCH1	23007	broad.mit.edu	37	3	155200527	155200527	+	Silent	SNP	A	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr3:155200527A>G	uc011bok.1	-	23	3589	c.3312T>C	c.(3310-3312)GGT>GGC	p.G1104G	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.G1066G	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1104					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGATTTTCACACCATGCAGAT	0.473000													49	170					0	0	0	0
NLGN1	22871	broad.mit.edu	37	3	173997073	173997073	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr3:173997073G>C	uc003fio.1	+	6	1705	c.1282G>C	c.(1282-1284)GGC>CGC	p.G428R	NLGN1_uc010hww.1_Missense_Mutation_p.G468R|NLGN1_uc003fip.1_Missense_Mutation_p.G428R	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	445	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			ATATCCTGAAGGCAAAGATGT	0.343000													6	90					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	65					0	0	0	0
WDFY3	23001	broad.mit.edu	37	4	85752750	85752750	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr4:85752750C>T	uc003hpd.2	-	8	993	c.585G>A	c.(583-585)GTG>GTA	p.V195V	WDFY3_uc003hpf.2_Silent_p.V195V	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	195						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TGCACAGTTTCactaagatct	0.249000													18	41					0	0	0	0
SLC39A8	64116	broad.mit.edu	37	4	103226195	103226195	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr4:103226195A>T	uc003hwb.1	-	4	1155	c.626T>A	c.(625-627)CTT>CAT	p.L209H	SLC39A8_uc011ceo.1_Missense_Mutation_p.L209H|SLC39A8_uc003hwa.1_Missense_Mutation_p.L142H|SLC39A8_uc003hwc.2_Missense_Mutation_p.L209H	NM_022154	NP_071437	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter),	209	Helical; (Potential).					integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		AAAAAAGAAAAGTAGGTAAAA	0.348000													6	32					0	0	0	0
ARSJ	79642	broad.mit.edu	37	4	114823767	114823767	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr4:114823767G>C	uc003ibq.1	-	2	2351	c.1463C>G	c.(1462-1464)TCA>TGA	p.S488*	ARSJ_uc010imu.1_Nonsense_Mutation_p.S488*|ARSJ_uc010imv.1_Nonsense_Mutation_p.S316*	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	488						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		TTTGCCAGTTGACAAGGTGAT	0.512000													33	61					0	0	0	0
ADAM29	11086	broad.mit.edu	37	4	175897109	175897109	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr4:175897109T>A	uc003iuc.2	+	5	1103	c.433T>A	c.(433-435)TTT>ATT	p.F145I	ADAM29_uc003iud.2_Missense_Mutation_p.F145I|ADAM29_uc010irr.2_Missense_Mutation_p.F145I|ADAM29_uc011cki.1_Missense_Mutation_p.F145I	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	145					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TTCTACCACGTTTGAACATCT	0.383000													16	44					0	0	0	0
TTC23L	153657	broad.mit.edu	37	5	34845770	34845770	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr5:34845770G>A	uc003jiu.2	+	3	350	c.247G>A	c.(247-249)GAA>AAA	p.E83K		NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	83	Potential.						binding			central_nervous_system(1)	1						GCTGATTAAGGAAAAAATGGT	0.358000													3	28					0	0	0	0
PWWP2A	114825	broad.mit.edu	37	5	159520157	159520157	+	Silent	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr5:159520157G>C	uc011ded.1	-	2	1557	c.1500C>G	c.(1498-1500)GGC>GGG	p.G500G	PWWP2A_uc003lxv.3_Silent_p.G500G|PWWP2A_uc011dec.1_Silent_p.G500G	NM_001130864	NP_001124336	Q96N64	PWP2A_HUMAN	PWWP domain containing 2A isoform b	500											0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTGCCATCTTGCCACTCCGCA	0.537000													5	21					0	0	0	0
JARID2	3720	broad.mit.edu	37	6	15501599	15501599	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr6:15501599G>A	uc003nbj.2	+	8	2651	c.2407G>A	c.(2407-2409)GAC>AAC	p.D803N	JARID2_uc011div.1_Missense_Mutation_p.D631N|JARID2_uc011diw.1_Missense_Mutation_p.D765N	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	803					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGAGGAGGAGGACAAAGGCGT	0.587000													5	27					0	0	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032187	26032187	+	Silent	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr6:26032187G>T	uc003nfs.1	-	1	102	c.102C>A	c.(100-102)GGC>GGA	p.G34G		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	34					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						TTTTCACGCCGCCGGTAGCCG	0.627000													16	138					4.7546e-09	5.77345e-09	1	0
SCAND3	114821	broad.mit.edu	37	6	28554410	28554410	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr6:28554410C>T	uc003nlo.2	-	1	703	c.85G>A	c.(85-87)GAA>AAA	p.E29K	uc003nlp.1_5'Flank	NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	29					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGGTCTTCTTCTTTAACCTTT	0.502000													18	45					0	0	0	0
PAQR8	85315	broad.mit.edu	37	6	52268776	52268776	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr6:52268776C>T	uc003pao.3	+	2	939	c.765C>T	c.(763-765)TTC>TTT	p.F255F		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	255	Helical; Name=5; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					TCCTCTTCTTCCTGGTTAGCG	0.577000													23	52					0	0	0	0
FAM184A	79632	broad.mit.edu	37	6	119341142	119341142	+	Splice_Site	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr6:119341142C>T	uc003pyj.2	-	4	1680	c.1332_splice	c.e4+1	p.K444_splice	FAM184A_uc003pyk.3_Splice_Site_p.K324_splice|FAM184A_uc003pyl.3_Splice_Site_p.K324_splice	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1											ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TTACTTTTTACCTTCTCCAGT	0.398000													7	60					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129724979	129724979	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr6:129724979G>T	uc003qbn.2	+	40	5845	c.5740G>T	c.(5740-5742)GCT>TCT	p.A1914S	LAMA2_uc003qbo.2_Missense_Mutation_p.A1914S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1914	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CCTTGATGAGGCTAAAAACAT	0.398000													12	26					2.31682e-05	2.66522e-05	1	0
MAP3K4	4216	broad.mit.edu	37	6	161470492	161470492	+	Missense_Mutation	SNP	G	C	C	rs111941258		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr6:161470492G>C	uc003qtn.2	+	3	1330	c.1188G>C	c.(1186-1188)TGG>TGC	p.W396C	MAP3K4_uc010kkc.1_Missense_Mutation_p.W396C|MAP3K4_uc003qto.2_Missense_Mutation_p.W396C|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	396					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TCTGTTTGTGGTTAAACATCA	0.403000													10	54					0	0	0	0
MIOS	54468	broad.mit.edu	37	7	7613368	7613368	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr7:7613368C>T	uc003srf.2	+	4	1570	c.1262C>T	c.(1261-1263)CCA>CTA	p.P421L	MIOS_uc010ktp.1_Missense_Mutation_p.P421L	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	421	WD 6.										0						AATGAAGATCCACAGCTCAAG	0.408000													19	81					0	0	0	0
ADCY1	107	broad.mit.edu	37	7	45725669	45725669	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr7:45725669C>T	uc003tne.3	+	13	2200	c.2182C>T	c.(2182-2184)CAC>TAC	p.H728Y		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	728	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CGAGTCTACACACCATGCCCT	0.637000													16	61					0	0	0	0
DDC	1644	broad.mit.edu	37	7	50611693	50611693	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr7:50611693G>T	uc003tpf.3	-	2	177	c.91C>A	c.(91-93)CCT>ACT	p.P31T	DDC_uc010kza.2_Missense_Mutation_p.P31T|DDC_uc003tpg.3_Missense_Mutation_p.P31T	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	31					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	TCCACGTCAGGGTAGACCTGG	0.567000													28	253					1.61788e-16	1.98028e-16	1	0
PDAP1	11333	broad.mit.edu	37	7	99002548	99002548	+	Silent	SNP	C	A	A	rs139029496		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr7:99002548C>A	uc003uqe.2	-	2	163	c.42G>T	c.(40-42)GCG>GCT	p.A14A		NM_014891	NP_055706	Q13442	HAP28_HUMAN	PDGFA associated protein 1	14					cell proliferation|signal transduction						0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)		Becaplermin(DB00102)	TATACTGCCTCGCCCGGCCTT	0.632000													16	56					0.000422831	0.000465419	1	0
OR2A2	442361	broad.mit.edu	37	7	143806750	143806750	+	Silent	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr7:143806750C>G	uc011ktz.1	+	1	75	c.75C>G	c.(73-75)CTC>CTG	p.L25L		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	25	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					TGGCGATTCTCCTCTGTGGAC	0.517000													8	168					0	0	0	0
BRF2	55290	broad.mit.edu	37	8	37702008	37702008	+	Nonstop_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr8:37702008T>C	uc003xkk.2	-	4	1370	c.1260A>G	c.(1258-1260)TGA>TGG	p.*420W		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	420					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			TGGATATCCATCAGGGAGGGT	0.488000													15	44					0	0	0	0
KHDRBS3	10656	broad.mit.edu	37	8	136554958	136554958	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr8:136554958A>T	uc003yuv.2	+	3	663	c.269A>T	c.(268-270)GAA>GTA	p.E90V	KHDRBS3_uc003yuw.2_Missense_Mutation_p.E90V	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	90	KH.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			TTACAAGAAGAAACCTTGACA	0.363000													6	63					0	0	0	0
APBA1	320	broad.mit.edu	37	9	72082878	72082878	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr9:72082878C>T	uc004ahh.2	-	5	1619	c.1343G>A	c.(1342-1344)GGA>GAA	p.G448E		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	448	Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GTCGCAGGGTCCCGGAACTGT	0.557000													65	154					0	0	0	0
Unknown	0	broad.mit.edu	37	9	90746248	90746248	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr9:90746248C>G	uc011lti.1	-	4	1733	c.1704G>C	c.(1702-1704)GAG>GAC	p.E568D						SubName: Full=cDNA FLJ59639;																		TATGATTCCTCTCTGTGCGTC	0.532000													60	168					0	0	0	0
TNC	3371	broad.mit.edu	37	9	117808854	117808854	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr9:117808854T>G	uc004bjj.3	-	17	5322	c.4960A>C	c.(4960-4962)ATC>CTC	p.I1654L	TNC_uc010mvf.2_Intron	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1654	Fibronectin type-III 12.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GTATCTCTGATTTTGAGAACA	0.493000													43	135					0	0	0	0
PHF19	26147	broad.mit.edu	37	9	123632758	123632758	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr9:123632758C>T	uc004bks.1	-	4	580	c.327G>A	c.(325-327)CCG>CCA	p.P109P	PHF19_uc011lyf.1_5'Flank|PHF19_uc004bkr.2_5'Flank|PHF19_uc004bkt.2_Silent_p.P109P|PHF19_uc010mvk.2_Silent_p.P109P	NM_015651	NP_056466	Q5T6S3	PHF19_HUMAN	PHD finger protein 19 isoform a	109	PHD-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|breast(1)	2						TCTCATTCAGCGGCCCTGATG	0.627000													24	183					0	0	0	0
LCN1	3933	broad.mit.edu	37	9	138415134	138415134	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr9:138415134G>A	uc004cfz.1	+	3	336	c.278G>A	c.(277-279)GGA>GAA	p.G93E	LCN1_uc004cga.1_Missense_Mutation_p.G93E	NM_002297	NP_002288	P31025	LCN1_HUMAN	lipocalin 1 precursor	93					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		GACGAGCCGGGAAAATACACG	0.632000													5	45					0	0	0	0
FRMPD4	9758	broad.mit.edu	37	X	12734834	12734834	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:12734834C>T	uc004cuz.1	+	15	2762	c.2256C>T	c.(2254-2256)GAC>GAT	p.D752D	FRMPD4_uc011mij.1_Silent_p.D744D	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	752					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGGACGAGGACGAGGTGAGCT	0.582000													6	142					0	0	0	0
KDM6A	7403	broad.mit.edu	37	X	44949094	44949094	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:44949094T>A	uc004dge.3	+	25	4030	c.3655T>A	c.(3655-3657)TGG>AGG	p.W1219R	KDM6A_uc011mkz.1_Missense_Mutation_p.W1271R|KDM6A_uc011mla.1_Missense_Mutation_p.W1174R|KDM6A_uc011mlb.1_Missense_Mutation_p.W1226R|KDM6A_uc011mlc.1_Missense_Mutation_p.W923R|KDM6A_uc011mld.1_Missense_Mutation_p.W858R	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1219	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AGATTTGGTCTGGATAAATGC	0.408000			D|N|F|S		renal|oesophageal SCC|MM								7	34					0	0	0	0
CCDC120	90060	broad.mit.edu	37	X	48921913	48921913	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:48921913G>A	uc010nik.2	+	6	844	c.337G>A	c.(337-339)GAG>AAG	p.E113K	CCDC120_uc011mmq.1_Missense_Mutation_p.E101K|CCDC120_uc004dmf.2_Missense_Mutation_p.E113K|CCDC120_uc010nil.2_Missense_Mutation_p.E113K|CCDC120_uc011mmr.1_Missense_Mutation_p.E113K|CCDC120_uc011mms.1_Missense_Mutation_p.E101K	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	113	Potential.						protein binding			pancreas(1)	1						GCTGGCTCTTGAGGCCCTGGA	0.677000													4	1					0	0	0	0
CLCN5	1184	broad.mit.edu	37	X	49854987	49854987	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:49854987G>A	uc004dos.1	+	10	1997	c.1749G>A	c.(1747-1749)ATG>ATA	p.M583I	CLCN5_uc004dor.1_Missense_Mutation_p.M653I|CLCN5_uc004doq.1_Missense_Mutation_p.M653I|CLCN5_uc004dot.1_Missense_Mutation_p.M583I	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	583	Cytoplasmic (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					CCCTGGCAATGGATGTGATGA	0.468000													4	65					0	0	0	0
CHIC1	53344	broad.mit.edu	37	X	72797282	72797282	+	Silent	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:72797282C>G	uc004ebk.3	+	2	473	c.336C>G	c.(334-336)TCC>TCG	p.S112S	CHIC1_uc010nlo.2_RNA|CHIC1_uc011mql.1_Silent_p.S112S|CHIC1_uc004ebl.3_Silent_p.S112S	NM_001039840	NP_001034929	Q5VXU3	CHIC1_HUMAN	cysteine-rich hydrophobic domain 1	112						cytoplasmic membrane-bounded vesicle|plasma membrane					0	Renal(35;0.156)					AATTTCCCTCCGTTCTAACAG	0.343000													18	138					0	0	0	0
KLHL4	56062	broad.mit.edu	37	X	86888820	86888820	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:86888820G>A	uc004efb.2	+	8	1803	c.1621G>A	c.(1621-1623)GAA>AAA	p.E541K	KLHL4_uc004efa.2_Missense_Mutation_p.E541K	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	541	Kelch 3.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						AAATACTGTAGAAAGATGGGA	0.413000													4	59					0	0	0	0
GPRASP2	114928	broad.mit.edu	37	X	101971267	101971267	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:101971267C>T	uc004ejk.2	+	4	2804	c.1470C>T	c.(1468-1470)ACC>ACT	p.T490T	GPRASP2_uc004ejl.2_Silent_p.T490T|GPRASP2_uc004ejm.2_Silent_p.T490T|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	490						cytoplasm	protein binding			ovary(1)	1						GGCCCCAAACCTGGGACGAGG	0.507000													30	121					0	0	0	0
PRPS1	5631	broad.mit.edu	37	X	106888430	106888430	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:106888430T>C	uc004ene.3	+	5	759	c.554T>C	c.(553-555)CTG>CCG	p.L185P	PRPS1_uc010npg.2_Missense_Mutation_p.L152P|PRPS1_uc011msj.1_5'UTR	NM_002764	NP_002755	P60891	PRPS1_HUMAN	phosphoribosyl pyrophosphate synthetase 1	185					5-phosphoribose 1-diphosphate biosynthetic process|hypoxanthine biosynthetic process|nervous system development|nucleoside metabolic process|purine nucleotide biosynthetic process|pyrimidine nucleotide biosynthetic process|ribonucleoside monophosphate biosynthetic process|urate biosynthetic process	cytosol	ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(3)|large_intestine(1)	4						GCAGACAGGCTGAATGTGGAC	0.438000													9	286					0	0	0	0
IRS4	8471	broad.mit.edu	37	X	107978579	107978579	+	Silent	SNP	A	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:107978579A>G	uc004eoc.2	-	1	1029	c.996T>C	c.(994-996)TGT>TGC	p.C332C		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	332	IRS-type PTB.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						ATTCGTCTGCACACAAGGCTC	0.587000													100	199					0	0	0	0
DCX	1641	broad.mit.edu	37	X	110644290	110644290	+	Silent	SNP	G	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:110644290G>C	uc004epd.2	-	3	1048	c.876C>G	c.(874-876)CTC>CTG	p.L292L	DCX_uc011msv.1_Silent_p.L292L|DCX_uc004epe.2_Silent_p.L211L|DCX_uc004epf.2_Silent_p.L211L|DCX_uc004epg.2_Silent_p.L211L	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	292	Doublecortin 2.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						TGATATCAGTGAGGACTTGCT	0.493000													62	100					0	0	0	0
ALG13	79868	broad.mit.edu	37	X	110979971	110979971	+	Silent	SNP	T	C	C			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:110979971T>C	uc011msy.1	+	23	2593	c.2559T>C	c.(2557-2559)GCT>GCC	p.A853A	ALG13_uc011msx.1_Silent_p.A749A|ALG13_uc011msz.1_Silent_p.A775A|ALG13_uc011mta.1_Silent_p.A749A|ALG13_uc011mtb.1_Silent_p.A749A			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	853					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						CAGTTGCAGCTTCCTGTGCCA	0.403000													21	171					0	0	0	0
AKAP14	158798	broad.mit.edu	37	X	119054501	119054501	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:119054501G>T	uc004ese.2	+	7	663	c.525G>T	c.(523-525)TGG>TGT	p.W175C	AKAP14_uc004esf.2_Missense_Mutation_p.W115C	NM_178813	NP_848928	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14 isoform a	175						cytoplasm					0						GAGAAAACTGGCAGAAGAATC	0.338000													19	39					1.15919e-05	1.35386e-05	1	0
CUL4B	8450	broad.mit.edu	37	X	119666336	119666336	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:119666336C>G	uc004esw.2	-	20	2871	c.2434G>C	c.(2434-2436)GAT>CAT	p.D812H	CUL4B_uc010nqq.2_Missense_Mutation_p.D513H|CUL4B_uc004esv.2_Missense_Mutation_p.D794H	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	812					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						TTGAAATCATCATTACAAATG	0.368000													15	45					0	0	0	0
GRIA3	2892	broad.mit.edu	37	X	122459926	122459926	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:122459926G>T	uc004etq.3	+	5	851	c.558G>T	c.(556-558)TGG>TGT	p.W186C	GRIA3_uc004etr.3_Missense_Mutation_p.W186C|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.W170C	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	186	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	AAAACAACTGGCAAGTAACAG	0.418000													15	46					0.000308642	0.00034219	1	0
PLXNA3	55558	broad.mit.edu	37	X	153698126	153698126	+	Silent	SNP	C	T	T			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:153698126C>T	uc004flm.2	+	28	4967	c.4794C>T	c.(4792-4794)TAC>TAT	p.Y1598Y		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1598	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCAGCCGCTACGGTAGGTGTC	0.582000													17	49					0	0	0	0
UTS2	10911	broad.mit.edu	37	1	7913185	7913185	+	5'Flank	DEL	A	-	-	rs34962249		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:7913185delA	uc001aor.2	-						UTS2_uc001aoq.2_Intron|UTS2_uc001aos.2_Intron	NM_006786	NP_006777	O95399	UTS2_HUMAN	urotensin 2 isoform b preproprotein						muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity				0	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		CATCCTCTCCAAAAAAAAAAA	0.338													---	---	---							
OR10X1	128367	broad.mit.edu	37	1	158548862	158548862	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:158548862delC	uc010pin.1	-	1	828	c.828delG	c.(826-828)TTGfs	p.L276fs		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	276	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CTTCTGGCTTCAAATAAACAA	0.493													---	---	---							
LYST	1130	broad.mit.edu	37	1	235972380	235972385	+	In_Frame_Del	DEL	TGTTAT	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr1:235972380_235972385delTGTTAT	uc001hxj.2	-	5	1908_1913	c.1733_1738delATAACA	c.(1732-1740)CATAACATT>CTT	p.578_580HNI>L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_In_Frame_Del_p.578_580HNI>L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	578_580					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CATATTCCAATGTTATGAACACCCGA	0.442									Chediak-Higashi_syndrome				---	---	---							
TRIM21	6737	broad.mit.edu	37	11	4406682	4406684	+	In_Frame_Del	DEL	AGA	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:4406682_4406684delAGA	uc001lyy.1	-	7	1372_1374	c.1259_1261delTCT	c.(1258-1263)TTCTAC>TAC	p.F420del		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	420	B30.2/SPRY.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		GTGATGTTGTAGAAGGAGACCAT	0.532													---	---	---							
OR5M11	219487	broad.mit.edu	37	11	56310877	56310878	+	5'Flank	INS	-	TT	TT	rs137998724	by1000genomes	TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:56310877_56310878insTT	uc010rjl.1	-							NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTACCATAAACTGGTTTTGGTA	0.287													---	---	---							
VPS37C	55048	broad.mit.edu	37	11	60899313	60899313	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr11:60899313delC	uc001nqv.1	-	5	1107	c.1047delG	c.(1045-1047)GGGfs	p.G349fs		NM_017966	NP_060436	A5D8V6	VP37C_HUMAN	vacuolar protein sorting 37C	349	Pro-rich.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0						GCCAGGCAGGCCCCGGCGGTG	0.697													---	---	---							
KRT73	319101	broad.mit.edu	37	12	53007615	53007616	+	Frame_Shift_Del	DEL	GG	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:53007615_53007616delGG	uc001sas.2	-	5	875_876	c.840_841delCC	c.(838-843)TCCCACfs	p.S280fs		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	280_281	Rod.|Linker 12.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCGCTGATGTGGGACTGGATCT	0.559													---	---	---							
STAC3	246329	broad.mit.edu	37	12	57640658	57640659	+	Frame_Shift_Del	DEL	AC	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:57640658_57640659delAC	uc001snp.2	-	6	726_727	c.531_532delGT	c.(529-534)GTGTTTfs	p.V177fs	STAC3_uc009zpl.2_5'UTR|STAC3_uc001snq.2_Frame_Shift_Del_p.V138fs|STAC3_uc010srm.1_5'UTR	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	177_178					intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						AGGGTTTCAAACACAGGATCAT	0.510													---	---	---							
Unknown	0	broad.mit.edu	37	12	79893822	79893823	+	IGR	DEL	TT	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr12:79893822_79893823delTT								SYT1 (48035 upstream) : PAWR (91924 downstream)																							TTGACCTGGCtttttttttttt	0.272													---	---	---							
JUB	84962	broad.mit.edu	37	14	23450563	23450563	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr14:23450563delC	uc001whz.2	-	1	1289	c.913delG	c.(913-915)GAGfs	p.E305fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	305	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CCCGACGGCTCAATCCCCGAG	0.697													---	---	---							
Unknown	0	broad.mit.edu	37	16	32126700	32126726	+	IGR	DEL	AATGTGAACATACAAAAAACAAATCAG	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr16:32126700_32126726delAATGTGAACATACAAAAAACAAATCAG								ZNF267 (198074 upstream) : HERC2P4 (35884 downstream)																							ATGCCTGCCAAATGTGAACATACAAAAAACAAATCAGAATGTGCCAT	0.352													---	---	---							
DOCK6	57572	broad.mit.edu	37	19	11313343	11313343	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr19:11313343delG	uc002mqs.3	-	42	5319	c.5278delC	c.(5278-5280)CACfs	p.H1760fs	DOCK6_uc002mqr.3_Frame_Shift_Del_p.H160fs|DOCK6_uc010xlq.1_Frame_Shift_Del_p.H1099fs	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1760	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TCACCGAAGTGGGCGCCGTAG	0.617													---	---	---							
FBXO48	554251	broad.mit.edu	37	2	68691399	68691400	+	Frame_Shift_Del	DEL	AT	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:68691399_68691400delAT	uc002seo.2	-	4	817_818	c.409_410delAT	c.(409-411)ATGfs	p.M137fs		NM_001024680	NP_001019851	Q5FWF7	FBX48_HUMAN	F-box protein 48	137											0						CATTGGGTACATGATTTTTTCT	0.391													---	---	---							
Unknown	0	broad.mit.edu	37	2	217475010	217475010	+	IGR	DEL	G	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr2:217475010delG								RPL37A (108824 upstream) : IGFBP2 (23117 downstream)																							ttttttttttGAAAGAAAGGC	0.368													---	---	---							
Unknown	0	broad.mit.edu	37	21	9865569	9865570	+	IGR	INS	-	A	A	rs77497487	by1000genomes	TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr21:9865569_9865570insA								None (None upstream) : None (None downstream)																							CTGCTGAGTTTAAATCTTCCTT	0.490													---	---	---							
TPD52L1	7164	broad.mit.edu	37	6	125541335	125541345	+	Splice_Site	DEL	TTCAGGTATGT	-	-	rs111553148		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr6:125541335_125541345delTTCAGGTATGT	uc003pzu.1	+	2	354	c.135_splice	c.e2+1	p.Q45_splice	TPD52L1_uc003pzv.1_Splice_Site_p.Q45_splice|TPD52L1_uc003pzw.1_Splice_Site_p.Q45_splice|TPD52L1_uc003pzx.1_Splice_Site_p.Q16_splice|TPD52L1_uc003pzy.1_Splice_Site_p.Q16_splice|TPD52L1_uc003pzz.1_Splice_Site_p.Q16_splice	NM_003287	NP_003278	Q16890	TPD53_HUMAN	tumor protein D52-like 1 isoform 1						DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		GCAGAGTTAGTTCAGGTATGTTTAGTAATCT	0.355													---	---	---							
Unknown	0	broad.mit.edu	37	7	57929445	57929445	+	IGR	DEL	A	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr7:57929445delA								ZNF716 (396180 upstream) : None (None downstream)																							ACAAGAGACTAGGGGGATAAG	0.403													---	---	---							
DEPDC6	64798	broad.mit.edu	37	8	120977486	120977486	+	Frame_Shift_Del	DEL	A	-	-	rs35198895		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr8:120977486delA	uc003yow.3	+	4	627	c.440delA	c.(439-441)GAAfs	p.E147fs	DEPDC6_uc011lid.1_Frame_Shift_Del_p.E46fs	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	147	DEP 2.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATGAGCCCTGAAAACACACTC	0.468													---	---	---							
OR13C5	138799	broad.mit.edu	37	9	107361898	107361899	+	5'Flank	INS	-	GAAT	GAAT	rs139149858	by1000genomes	TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chr9:107361898_107361899insGAAT	uc011lvp.1	-							NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						gagagggaagggaatgaatgaa	0.030													---	---	---							
Unknown	0	broad.mit.edu	37	X	844350	844351	+	IGR	DEL	GA	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:844350_844351delGA								SHOX (224205 upstream) : CRLF2 (470536 downstream)																							gagagagagggagagagagaga	0.069													---	---	---							
RPS6KA6	27330	broad.mit.edu	37	X	83442984	83442986	+	5'Flank	DEL	CCG	-	-	rs111507044		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:83442984_83442986delCCG	uc004eej.1	-						RPS6KA6_uc011mqt.1_5'Flank|RPS6KA6_uc011mqu.1_5'Flank	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6						axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TTGAACTGGCccgccgccgccgc	0.567													---	---	---							
Unknown	0	broad.mit.edu	37	X	101870740	101870740	+	IGR	DEL	T	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	cc2cb7ff-1c89-4a0b-b833-9d9a6848293d	g.chrX:101870740delT								ARMCX5 (11657 upstream) : GPRASP1 (35554 downstream)																							GGTGGCCAGattttttttttg	0.289													---	---	---							
OR10X1	128367	broad.mit.edu	37	1	158548862	158548862	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:158548862delC	uc010pin.1	-	1	828	c.828delG	c.(826-828)TTGfs	p.L276fs		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	276	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CTTCTGGCTTCAAATAAACAA	0.493													---	---	---							
LYST	1130	broad.mit.edu	37	1	235972380	235972385	+	In_Frame_Del	DEL	TGTTAT	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr1:235972380_235972385delTGTTAT	uc001hxj.2	-	5	1908_1913	c.1733_1738delATAACA	c.(1732-1740)CATAACATT>CTT	p.578_580HNI>L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_In_Frame_Del_p.578_580HNI>L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	578_580					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CATATTCCAATGTTATGAACACCCGA	0.442									Chediak-Higashi_syndrome				---	---	---							
TRIM21	6737	broad.mit.edu	37	11	4406682	4406684	+	In_Frame_Del	DEL	AGA	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr11:4406682_4406684delAGA	uc001lyy.1	-	7	1372_1374	c.1259_1261delTCT	c.(1258-1263)TTCTAC>TAC	p.F420del		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	420	B30.2/SPRY.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		GTGATGTTGTAGAAGGAGACCAT	0.532													---	---	---							
VPS37C	55048	broad.mit.edu	37	11	60899313	60899313	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr11:60899313delC	uc001nqv.1	-	5	1107	c.1047delG	c.(1045-1047)GGGfs	p.G349fs		NM_017966	NP_060436	A5D8V6	VP37C_HUMAN	vacuolar protein sorting 37C	349	Pro-rich.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0						GCCAGGCAGGCCCCGGCGGTG	0.697													---	---	---							
KRT73	319101	broad.mit.edu	37	12	53007615	53007616	+	Frame_Shift_Del	DEL	GG	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr12:53007615_53007616delGG	uc001sas.2	-	5	875_876	c.840_841delCC	c.(838-843)TCCCACfs	p.S280fs		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	280_281	Rod.|Linker 12.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCGCTGATGTGGGACTGGATCT	0.559													---	---	---							
STAC3	246329	broad.mit.edu	37	12	57640658	57640659	+	Frame_Shift_Del	DEL	AC	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr12:57640658_57640659delAC	uc001snp.2	-	6	726_727	c.531_532delGT	c.(529-534)GTGTTTfs	p.V177fs	STAC3_uc009zpl.2_5'UTR|STAC3_uc001snq.2_Frame_Shift_Del_p.V138fs|STAC3_uc010srm.1_5'UTR	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	177_178					intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						AGGGTTTCAAACACAGGATCAT	0.510													---	---	---							
JUB	84962	broad.mit.edu	37	14	23450563	23450563	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr14:23450563delC	uc001whz.2	-	1	1289	c.913delG	c.(913-915)GAGfs	p.E305fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	305	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CCCGACGGCTCAATCCCCGAG	0.697													---	---	---							
Unknown	0	broad.mit.edu	37	16	32126700	32126726	+	IGR	DEL	AATGTGAACATACAAAAAACAAATCAG	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr16:32126700_32126726delAATGTGAACATACAAAAAACAAATCAG								ZNF267 (198074 upstream) : HERC2P4 (35884 downstream)																							ATGCCTGCCAAATGTGAACATACAAAAAACAAATCAGAATGTGCCAT	0.352													---	---	---							
DOCK6	57572	broad.mit.edu	37	19	11313343	11313343	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr19:11313343delG	uc002mqs.3	-	42	5319	c.5278delC	c.(5278-5280)CACfs	p.H1760fs	DOCK6_uc002mqr.3_Frame_Shift_Del_p.H160fs|DOCK6_uc010xlq.1_Frame_Shift_Del_p.H1099fs	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1760	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TCACCGAAGTGGGCGCCGTAG	0.617													---	---	---							
FBXO48	554251	broad.mit.edu	37	2	68691399	68691400	+	Frame_Shift_Del	DEL	AT	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr2:68691399_68691400delAT	uc002seo.2	-	4	817_818	c.409_410delAT	c.(409-411)ATGfs	p.M137fs		NM_001024680	NP_001019851	Q5FWF7	FBX48_HUMAN	F-box protein 48	137											0						CATTGGGTACATGATTTTTTCT	0.391													---	---	---							
TPD52L1	7164	broad.mit.edu	37	6	125541335	125541345	+	Splice_Site	DEL	TTCAGGTATGT	-	-	rs111553148		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr6:125541335_125541345delTTCAGGTATGT	uc003pzu.1	+	2	354	c.135_splice	c.e2+1	p.Q45_splice	TPD52L1_uc003pzv.1_Splice_Site_p.Q45_splice|TPD52L1_uc003pzw.1_Splice_Site_p.Q45_splice|TPD52L1_uc003pzx.1_Splice_Site_p.Q16_splice|TPD52L1_uc003pzy.1_Splice_Site_p.Q16_splice|TPD52L1_uc003pzz.1_Splice_Site_p.Q16_splice	NM_003287	NP_003278	Q16890	TPD53_HUMAN	tumor protein D52-like 1 isoform 1						DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		GCAGAGTTAGTTCAGGTATGTTTAGTAATCT	0.355													---	---	---							
MAP3K4	4216	broad.mit.edu	37	6	161413044	161413045	+	In_Frame_Ins	INS	-	CCG	CCG			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr6:161413044_161413045insCCG	uc003qtn.2	+	1	223_224	c.81_82insCCG	c.(79-84)insCCG	p.36_37insP	MAP3K4_uc010kkc.1_In_Frame_Ins_p.36_37insP|MAP3K4_uc003qto.2_In_Frame_Ins_p.36_37insP|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	36_37	Poly-Pro.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		Agccgccgccaccgccgccgcc	0.574													---	---	---							
Unknown	0	broad.mit.edu	37	7	57929445	57929445	+	IGR	DEL	A	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr7:57929445delA								ZNF716 (396180 upstream) : None (None downstream)																							ACAAGAGACTAGGGGGATAAG	0.403													---	---	---							
DEPDC6	64798	broad.mit.edu	37	8	120977486	120977486	+	Frame_Shift_Del	DEL	A	-	-	rs35198895		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chr8:120977486delA	uc003yow.3	+	4	627	c.440delA	c.(439-441)GAAfs	p.E147fs	DEPDC6_uc011lid.1_Frame_Shift_Del_p.E46fs	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	147	DEP 2.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATGAGCCCTGAAAACACACTC	0.468													---	---	---							
Unknown	0	broad.mit.edu	37	X	844350	844351	+	IGR	DEL	GA	-	-			TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:844350_844351delGA								SHOX (224205 upstream) : CRLF2 (470536 downstream)																							gagagagagggagagagagaga	0.069													---	---	---							
RPS6KA6	27330	broad.mit.edu	37	X	83442984	83442986	+	5'Flank	DEL	CCG	-	-	rs111507044		TCGA-CV-7177-01A-11D-2012-08	TCGA-CV-7177-11A-01D-2012-08									Somatic	Phase_I	Capture				Illumina GAIIx	c984165c-88ea-4840-a980-be818db16820	77a82ab0-ef13-4632-aa37-ebe89f111306	g.chrX:83442984_83442986delCCG	uc004eej.1	-						RPS6KA6_uc011mqt.1_5'Flank|RPS6KA6_uc011mqu.1_5'Flank	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6						axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TTGAACTGGCccgccgccgccgc	0.567													---	---	---							
