Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
MST1P2	11209	broad.mit.edu	37	1	16974224	16974224	+	RNA	SNP	C	G	G	rs148702086	by1000genomes	TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:16974224C>G	uc009vow.2	+	5		c.1034C>G			MST1P2_uc010ocg.1_RNA|MST1P2_uc010och.1_Intron|MST1P2_uc010oci.1_RNA|MST1P2_uc001azk.2_Intron|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_Intron|MST1P2_uc001azm.3_Intron					Homo sapiens cDNA FLJ53774 complete cds, moderately similar to Hepatocyte growth factor-like protein precursor.												0						TTGGTCCCAGCCCCAGAGGGA	0.652													4	15					0	0	0	0
LUZP1	7798	broad.mit.edu	37	1	23419092	23419092	+	Missense_Mutation	SNP	C	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:23419092C>A	uc001bgk.2	-	4	2047	c.1663G>T	c.(1663-1665)GCT>TCT	p.A555S	LUZP1_uc010odv.1_Missense_Mutation_p.A555S|LUZP1_uc001bgl.2_Missense_Mutation_p.A555S|LUZP1_uc001bgm.1_Missense_Mutation_p.A555S	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	555						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		GAGTTTGCAGCCTGAGTTACT	0.537													4	97					0.000602214	0.000774276	1	0
EXTL1	2134	broad.mit.edu	37	1	26349468	26349468	+	Missense_Mutation	SNP	C	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:26349468C>G	uc001blf.2	+	1	1198	c.331C>G	c.(331-333)CAT>GAT	p.H111D		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	111	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTGAGACTCATCGCAGGAT	0.577													5	58					0	0	0	0
GBP4	115361	broad.mit.edu	37	1	89655859	89655859	+	Missense_Mutation	SNP	C	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:89655859C>G	uc001dnb.2	-	7	1175	c.1059G>C	c.(1057-1059)ATG>ATC	p.M353I		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	353						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		GTTGCTGGGCCATCTGCTGGC	0.602													4	57					0	0	0	0
DENND2D	79961	broad.mit.edu	37	1	111742266	111742266	+	Missense_Mutation	SNP	T	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:111742266T>C	uc001eak.1	-	2	422	c.222A>G	c.(220-222)ATA>ATG	p.I74M	DENND2D_uc001eal.1_Missense_Mutation_p.I71M	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	74	UDENN.									ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		GGTAGGTGATTATAGGCTCGT	0.522													11	156					0	0	0	0
SPTA1	6708	broad.mit.edu	37	1	158627412	158627412	+	Missense_Mutation	SNP	C	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:158627412C>A	uc001fst.1	-	19	2859	c.2660G>T	c.(2659-2661)CGA>CTA	p.R887L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	887	Spectrin 9.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCTAGCAGCTCGAGCACGGAG	0.473													6	140					0.00198382	0.00243469	1	0
ATF6	22926	broad.mit.edu	37	1	161928411	161928411	+	Missense_Mutation	SNP	C	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:161928411C>G	uc001gbr.2	+	16	2047	c.1980C>G	c.(1978-1980)CAC>CAG	p.H660Q	ATF6_uc001gbs.2_RNA	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	660	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			AGGCAACCCACGTTGTCAGCA	0.522													5	112					0	0	0	0
DNAH14	127602	broad.mit.edu	37	1	225155247	225155247	+	Missense_Mutation	SNP	A	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:225155247A>G	uc001how.2	+	6	828	c.613A>G	c.(613-615)AAA>GAA	p.K205E	DNAH14_uc001hou.3_Missense_Mutation_p.K205E|DNAH14_uc001hot.3_Intron|DNAH14_uc001hov.3_Missense_Mutation_p.K205E	NM_001373	NP_001364	Q0VDD8	DYH14_HUMAN	dynein, axonemal, heavy polypeptide 14 isoform	332					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1						TAAACATTGCAAAGAATTTTG	0.323													7	71					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237777923	237777923	+	Missense_Mutation	SNP	G	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:237777923G>C	uc001hyl.1	+	37	5615	c.5495G>C	c.(5494-5496)GGC>GCC	p.G1832A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1832	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGATCATGGGCATCTTTCAC	0.502													5	160					0	0	0	0
TRIM58	25893	broad.mit.edu	37	1	248023998	248023998	+	Missense_Mutation	SNP	A	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:248023998A>G	uc001ido.2	+	2	548	c.500A>G	c.(499-501)AAG>AGG	p.K167R		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	167						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GTGGGGAAAAAGACTGTCATT	0.478													5	72					0	0	0	0
OR2L8	391190	broad.mit.edu	37	1	248112599	248112599	+	Missense_Mutation	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr1:248112599C>T	uc001idt.1	+	1	440	c.440C>T	c.(439-441)TCT>TTT	p.S147F	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ATAACAGGGTCTTGGATCATA	0.438													8	167					0	0	0	0
PARD3	56288	broad.mit.edu	37	10	34673066	34673066	+	Missense_Mutation	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr10:34673066C>T	uc010qej.1	-	8	1007	c.1007G>A	c.(1006-1008)AGA>AAA	p.R336K	PARD3_uc010qek.1_Missense_Mutation_p.R336K|PARD3_uc010qel.1_Missense_Mutation_p.R336K|PARD3_uc010qem.1_Missense_Mutation_p.R336K|PARD3_uc010qen.1_Missense_Mutation_p.R336K|PARD3_uc010qeo.1_Missense_Mutation_p.R336K|PARD3_uc010qep.1_Missense_Mutation_p.R292K|PARD3_uc010qeq.1_Missense_Mutation_p.R292K|PARD3_uc001ixo.1_Missense_Mutation_p.R66K|PARD3_uc001ixp.1_Missense_Mutation_p.R201K|PARD3_uc001ixq.1_Missense_Mutation_p.R336K|PARD3_uc001ixr.1_Missense_Mutation_p.R336K|PARD3_uc001ixt.1_Missense_Mutation_p.R157K|PARD3_uc001ixu.1_Missense_Mutation_p.R292K|PARD3_uc001ixs.1_5'UTR	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	336	PDZ 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CTGTTCAAATCTTCTATTTCG	0.398													4	60					0	0	0	0
RUFY2	55680	broad.mit.edu	37	10	70141060	70141060	+	Missense_Mutation	SNP	T	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr10:70141060T>C	uc001job.2	-	11	1468	c.1141A>G	c.(1141-1143)ACT>GCT	p.T381A	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Missense_Mutation_p.T312A|RUFY2_uc010qiw.1_Missense_Mutation_p.T288A|RUFY2_uc001jod.1_Missense_Mutation_p.T346A	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	395	Potential.					nucleus	metal ion binding			ovary(1)	1						CCTATCAGAGTATCTTGTTTC	0.363													9	101					0	0	0	0
P2RY6	5031	broad.mit.edu	37	11	73008161	73008161	+	Missense_Mutation	SNP	G	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr11:73008161G>T	uc001otm.2	+	4	1003	c.598G>T	c.(598-600)GGC>TGC	p.G200C	P2RY6_uc001otn.2_Missense_Mutation_p.G200C|P2RY6_uc001oto.2_Missense_Mutation_p.G200C|P2RY6_uc001otp.2_Missense_Mutation_p.G200C|P2RY6_uc001otq.2_Missense_Mutation_p.G200C|P2RY6_uc001otr.2_Missense_Mutation_p.G200C|P2RY6_uc001ots.2_Missense_Mutation_p.G200C	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	200	Helical; Name=5; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						CACTGTCATCGGCTTCCTGCT	0.657													16	174					5.03518e-11	6.97179e-11	1	0
ARHGAP20	57569	broad.mit.edu	37	11	110450456	110450456	+	Missense_Mutation	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr11:110450456C>T	uc001pkz.1	-	16	3499	c.3214G>A	c.(3214-3216)GAG>AAG	p.E1072K	ARHGAP20_uc001pky.1_Missense_Mutation_p.E1049K|ARHGAP20_uc009yyb.1_Missense_Mutation_p.E1036K|ARHGAP20_uc001pla.1_Missense_Mutation_p.E1036K|ARHGAP20_uc001plb.2_Missense_Mutation_p.E615K	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1072					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GGGGGTGGCTCTAAGGGTCCT	0.498													7	159					0	0	0	0
PIWIL1	9271	broad.mit.edu	37	12	130831541	130831541	+	Missense_Mutation	SNP	C	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr12:130831541C>A	uc001uik.2	+	6	677	c.587C>A	c.(586-588)ACT>AAT	p.T196N	PIWIL1_uc001uij.1_Missense_Mutation_p.T196N	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	196					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATAACGATCACTTTAACAAAT	0.333													5	49					0.00116845	0.00146735	1	0
RFXAP	5994	broad.mit.edu	37	13	37399599	37399599	+	Missense_Mutation	SNP	A	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:37399599A>C	uc001uvu.1	+	2	791	c.635A>C	c.(634-636)CAA>CCA	p.Q212P		NM_000538	NP_000529	O00287	RFXAP_HUMAN	regulatory factor X-associated protein	212						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		ATTGTTAAACAAAGAACAGGA	0.318													4	81					0	0	0	0
FREM2	341640	broad.mit.edu	37	13	39358893	39358893	+	Silent	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:39358893C>T	uc001uwv.2	+	6	6276	c.5967C>T	c.(5965-5967)ATC>ATT	p.I1989I	FREM2_uc001uww.2_Silent_p.I75I	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1989	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGGGAAGAATCGGATCAGAGT	0.448													4	39					0	0	0	0
HNRNPA1L2	144983	broad.mit.edu	37	13	53217477	53217477	+	Nonsense_Mutation	SNP	A	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:53217477A>T	uc001vgx.1	+	7	1923	c.850A>T	c.(850-852)AGA>TGA	p.R284*	HNRNPA1L2_uc001vgy.1_Nonsense_Mutation_p.R284*|HNRNPA1L2_uc001vgz.1_Nonsense_Mutation_p.R284*	NM_001011724	NP_001011724	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like	284	Nuclear targeting sequence (By similarity).|Gly-rich.				mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding				0						TTTTGGAGGCAGAAGCTCTGG	0.418													5	101					0	0	0	0
PCDH8	5100	broad.mit.edu	37	13	53420356	53420356	+	Missense_Mutation	SNP	A	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:53420356A>C	uc001vhi.2	-	1	2419	c.2216T>G	c.(2215-2217)GTG>GGG	p.V739G	PCDH8_uc001vhj.2_Missense_Mutation_p.V739G	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	739	Extracellular (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CGACCCGGACACCCCGAGCCG	0.711													7	33					0	0	0	0
ZNF828	283489	broad.mit.edu	37	13	115090169	115090169	+	Silent	SNP	A	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr13:115090169A>T	uc010ahb.2	+	3	1181	c.852A>T	c.(850-852)TCA>TCT	p.S284S	ZNF828_uc001vuv.2_Silent_p.S284S|ZNF828_uc010tko.1_Silent_p.S284S	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	284	Mediates interaction with MAD2L2.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		CATCCCCTTCAGAGTCTCCTG	0.617													5	73					0	0	0	0
MYH6	4624	broad.mit.edu	37	14	23863348	23863348	+	Missense_Mutation	SNP	G	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr14:23863348G>T	uc001wjv.2	-	21	2681	c.2614C>A	c.(2614-2616)CGC>AGC	p.R872S		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	872	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		AGCTCCTTGCGGCGAGCCTCG	0.592													9	81					1.04858e-14	1.49008e-14	1	0
NID2	22795	broad.mit.edu	37	14	52508964	52508964	+	Missense_Mutation	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr14:52508964C>T	uc001wzo.2	-	7	1918	c.1684G>A	c.(1684-1686)GAT>AAT	p.D562N	NID2_uc010tqs.1_Missense_Mutation_p.D562N|NID2_uc010tqt.1_Missense_Mutation_p.D562N|NID2_uc001wzp.2_Missense_Mutation_p.D562N	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	562	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GCTCTGCCATCATTGCCCACG	0.597													16	198					0	0	0	0
FGF7	2252	broad.mit.edu	37	15	49776562	49776562	+	Missense_Mutation	SNP	A	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:49776562A>G	uc001zxn.2	+	4	975	c.446A>G	c.(445-447)AAC>AGC	p.N149S	C15orf33_uc001zxl.2_Intron|C15orf33_uc001zxm.2_Intron	NM_002009	NP_002000	P21781	FGF7_HUMAN	fibroblast growth factor 7 precursor	149					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity				0		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	AACCATTACAACACATATGCA	0.328													3	47					0	0	0	0
SLC24A1	9187	broad.mit.edu	37	15	65936825	65936825	+	Missense_Mutation	SNP	A	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:65936825A>G	uc010ujf.1	+	5	2401	c.2114A>G	c.(2113-2115)CAG>CGG	p.Q705R	SLC24A1_uc010ujd.1_Missense_Mutation_p.Q687R|SLC24A1_uc010uje.1_Missense_Mutation_p.Q687R|SLC24A1_uc010ujg.1_Missense_Mutation_p.Q705R|SLC24A1_uc010ujh.1_Missense_Mutation_p.Q687R|SLC24A1_uc010uji.1_Missense_Mutation_p.Q32R	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	705	Cytoplasmic (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						GCCCAACCCCAGGCCAAAGCA	0.547													2	6					0	0	0	0
LASS3	204219	broad.mit.edu	37	15	101016321	101016321	+	Missense_Mutation	SNP	T	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:101016321T>A	uc002bvz.2	-	9	1081	c.579A>T	c.(577-579)TTA>TTT	p.L193F	LASS3_uc002bwa.2_Missense_Mutation_p.L204F|LASS3_uc002bwb.2_Missense_Mutation_p.L193F	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	193	Helical; (Potential).|TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			CAAGTCTAAATAACAGAGACC	0.363													7	97					0	0	0	0
GPR139	124274	broad.mit.edu	37	16	20043921	20043921	+	Silent	SNP	G	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr16:20043921G>C	uc002dgu.1	-	2	360	c.198C>G	c.(196-198)CTC>CTG	p.L66L	GPR139_uc010vaw.1_5'UTR	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	66	Helical; Name=2; (Potential).					integral to membrane|plasma membrane				ovary(2)	2						CGAGTGCCAAGAGATAGTTGT	0.468													3	44					0	0	0	0
MT1A	4489	broad.mit.edu	37	16	56670369	56670369	+	5'Flank	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr16:56670369C>T	uc002ejq.2	+						MT1A_uc002eji.2_Intron|uc002ejo.1_RNA|uc002ejp.1_RNA	NM_005946	NP_005937	P04731	MT1A_HUMAN	metallothionein 1A							cytoplasm	cadmium ion binding|copper ion binding|zinc ion binding				0						TGCACGTGCGCCGGCTCCTGC	0.577													6	63					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578449	7578450	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:7578449_7578450CC>AA	uc002gim.2	-	5	674_675	c.480_481GG>TT	c.(478-483)ATGGCC>ATTTCC	p.160_161MA>IS	TP53_uc002gig.1_Missense_Mutation_p.160_161MA>IS|TP53_uc002gih.2_Missense_Mutation_p.160_161MA>IS|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.28_29MA>IS|TP53_uc010cng.1_Missense_Mutation_p.28_29MA>IS|TP53_uc002gii.1_Missense_Mutation_p.28_29MA>IS|TP53_uc010cnh.1_Missense_Mutation_p.160_161MA>IS|TP53_uc010cni.1_Missense_Mutation_p.160_161MA>IS|TP53_uc002gij.2_Missense_Mutation_p.160_161MA>IS|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.67_68MA>IS|TP53_uc002gio.2_Missense_Mutation_p.28_29MA>IS|TP53_uc010vug.1_Missense_Mutation_p.121_122MA>IS	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	160_161	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		MA -> IP (in a sporadic cancer; somatic mutation).|MA -> IS (in sporadic cancers; somatic mutation).|MA -> IT (in a sporadic cancer; somatic mutation).|A -> G (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A161T(44)|p.0?(7)|p.M160I(6)|p.M160K(4)|p.M160V(4)|p.M160L(3)|p.M160fs*10(3)|p.A161fs*9(3)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.V157_C176del20(1)|p.A161fs*19(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.M160T(1)|p.R156fs*18(1)|p.A161fs*10(1)|p.R156_A161del(1)|p.A161fs*20(1)|p.V157_M160delVRAM(1)|p.M160_A161>IS(1)|p.A161fs*8(1)|p.S149fs*72(1)|p.A161fs*7(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.A161S(1)|p.A161P(1)|p.V157_I162delVRAMAI(1)|p.A161F(1)|p.A159_Q167delAMAIYKQSQ(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGTAGATGGCCATGGCGCGGA	0.634		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	70					0	0	0	0
SLC47A1	55244	broad.mit.edu	37	17	19470127	19470127	+	Missense_Mutation	SNP	G	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:19470127G>T	uc002gvy.1	+	13	1217	c.1131G>T	c.(1129-1131)CAG>CAT	p.Q377H	SLC47A1_uc002gvx.2_Missense_Mutation_p.Q377H|SLC47A1_uc010vyz.1_Missense_Mutation_p.Q354H|SLC47A1_uc010cqp.1_Intron|SLC47A1_uc010cqq.1_Missense_Mutation_p.Q182H|SLC47A1_uc010vza.1_Missense_Mutation_p.Q89H|SLC47A1_uc010vzb.1_Missense_Mutation_p.Q111H|SLC47A1_uc010vzc.1_Missense_Mutation_p.Q49H	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	377	Helical; (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					TGGTGGCTCAGGTGGTTCCAA	0.378													5	57					0.00116845	0.00146735	1	0
FLJ36000	284124	broad.mit.edu	37	17	21904193	21904193	+	RNA	SNP	C	G	G	rs9904221	by1000genomes	TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:21904193C>G	uc002gza.2	+	1		c.132C>G				NR_027084				Homo sapiens cDNA FLJ36000 fis, clone TESTI2015180.												0						cagcctcaggcctgccaggac	0													6	71					0	0	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904197	21904197	+	RNA	SNP	C	T	T	rs9904223	by1000genomes	TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:21904197C>T	uc002gza.2	+	1		c.136C>T				NR_027084				Homo sapiens cDNA FLJ36000 fis, clone TESTI2015180.												0						ctcaggcctgccaggacggtg	0													6	71					0	0	0	0
SSH2	85464	broad.mit.edu	37	17	27958126	27958126	+	Silent	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:27958126C>T	uc002heo.1	-	15	4005	c.4005G>A	c.(4003-4005)CAG>CAA	p.Q1335Q	SSH2_uc010wbh.1_Silent_p.Q1362Q	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	1335					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						CTGGCTTGCTCTGCACAATAC	0.507													4	54					0	0	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43522926	43522926	+	Missense_Mutation	SNP	T	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:43522926T>G	uc002ija.2	-	9	2917	c.2747A>C	c.(2746-2748)CAC>CCC	p.H916P	PLEKHM1_uc010wjm.1_Missense_Mutation_p.H888P|PLEKHM1_uc002ijb.2_Missense_Mutation_p.H391P|PLEKHM1_uc010wjn.1_Missense_Mutation_p.H865P	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	916					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					CCCAATGAGGTGCATCCGCTC	0.617													6	73					0	0	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43522928	43522928	+	Missense_Mutation	SNP	C	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:43522928C>A	uc002ija.2	-	9	2915	c.2745G>T	c.(2743-2745)ATG>ATT	p.M915I	PLEKHM1_uc010wjm.1_Missense_Mutation_p.M887I|PLEKHM1_uc002ijb.2_Missense_Mutation_p.M390I|PLEKHM1_uc010wjn.1_Missense_Mutation_p.M864I	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	915					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					CAATGAGGTGCATCCGCTCCA	0.612													6	75					0.00448238	0.00537886	1	0
CASKIN2	57513	broad.mit.edu	37	17	73499583	73499583	+	Missense_Mutation	SNP	G	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr17:73499583G>T	uc002joc.2	-	17	2256	c.1706C>A	c.(1705-1707)GCA>GAA	p.A569E	CASKIN2_uc010wsc.1_Missense_Mutation_p.A487E	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	569	SAM 2.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGCCCCAGTGCACACAGCCA	0.642													4	41					1.024e-07	1.3999e-07	1	0
ALPK2	115701	broad.mit.edu	37	18	56203268	56203268	+	Missense_Mutation	SNP	T	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr18:56203268T>C	uc002lhj.3	-	5	4365	c.4151A>G	c.(4150-4152)GAT>GGT	p.D1384G	ALPK2_uc002lhk.1_Missense_Mutation_p.D715G	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1384							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GGCAGTGTGATCCATCTTGAG	0.428													4	118					0	0	0	0
THEG	51298	broad.mit.edu	37	19	371324	371324	+	Splice_Site	SNP	T	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:371324T>A	uc002lol.2	-	6	675	c.636_splice	c.e6-1	p.R212_splice	THEG_uc002lom.2_Splice_Site_p.R188_splice	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1						cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGTCGTCCTGGGGGAGGTC	0.463													6	163					0	0	0	0
STXBP2	6813	broad.mit.edu	37	19	7709561	7709561	+	Missense_Mutation	SNP	T	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:7709561T>C	uc002mha.3	+	14	1214	c.1169T>C	c.(1168-1170)GTT>GCT	p.V390A	STXBP2_uc002mhb.3_Missense_Mutation_p.V387A|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Missense_Mutation_p.V401A|STXBP2_uc010dvk.2_Missense_Mutation_p.V358A|STXBP2_uc002mhc.3_Missense_Mutation_p.V158A|STXBP2_uc002mhe.1_Missense_Mutation_p.V18A	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	390					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						AAGCTGATCGTTCCGGTGCTG	0.652													4	53					0	0	0	0
HRC	3270	broad.mit.edu	37	19	49657229	49657229	+	Silent	SNP	G	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:49657229G>C	uc002pmv.2	-	1	1453	c.1266C>G	c.(1264-1266)GTC>GTG	p.V422V		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	422					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CCTCCCTGGGGACTCTGTGGT	0.537													3	93					0	0	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55048220	55048220	+	Missense_Mutation	SNP	G	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:55048220G>C	uc010erm.2	+	1	100	c.88G>C	c.(88-90)GGA>CGA	p.G30R	KIR3DX1_uc010yfa.1_RNA|KIR3DX1_uc010yfb.1_RNA|KIR3DX1_uc010yfc.1_RNA|KIR3DX1_uc010yfd.1_RNA					Homo sapiens killer cell immunoglobulin-like receptor, three domains, X1, mRNA (cDNA clone IMAGE:4849085).											ovary(1)	1				GBM - Glioblastoma multiforme(193;0.099)		GGTTGCTCATGGACAGTGGCT	0.557													4	94					0	0	0	0
BOLA3	388962	broad.mit.edu	37	2	74362737	74362737	+	Missense_Mutation	SNP	A	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:74362737A>G	uc002skc.1	-	4	345	c.307T>C	c.(307-309)TCT>CCT	p.S103P	BOLA3_uc002skd.1_Missense_Mutation_p.L73P	NM_212552	NP_997717	Q53S33	BOLA3_HUMAN	bolA-like 3 isoform 1	103						extracellular region					0						TTGGGGACAGAGGTAAATATC	0.428													3	67					0	0	0	0
CD8A	925	broad.mit.edu	37	2	87013080	87013080	+	Nonsense_Mutation	SNP	G	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:87013080G>T	uc002srt.2	-	6	1560	c.671C>A	c.(670-672)TCG>TAG	p.S224*	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Nonsense_Mutation_p.S224*|CD8A_uc010ytn.1_Nonsense_Mutation_p.S265*|CD8A_uc002sru.2_Nonsense_Mutation_p.S187*	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	224	Cytoplasmic (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						CTTGTCTCCCGATTTGACCAC	0.547													7	163					5.18039e-06	6.99353e-06	1	0
THSD7B	80731	broad.mit.edu	37	2	137928343	137928343	+	Missense_Mutation	SNP	G	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:137928343G>A	uc002tva.1	+	6	1465	c.1465G>A	c.(1465-1467)GAA>AAA	p.E489K	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.E379K	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGTCCTCATGGAATCTACAGG	0.473													4	60					0	0	0	0
FAP	2191	broad.mit.edu	37	2	163039967	163039967	+	Missense_Mutation	SNP	T	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:163039967T>G	uc002ucd.2	-	21	2034	c.1826A>C	c.(1825-1827)GAA>GCA	p.E609A	FAP_uc010fpc.2_Missense_Mutation_p.E158A|FAP_uc010zct.1_Missense_Mutation_p.E584A|FAP_uc010fpd.2_Missense_Mutation_p.E88A	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	609	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						GAAACCCATTTCTATGAATTT	0.284													4	81					0	0	0	0
ATP5G3	518	broad.mit.edu	37	2	176043850	176043850	+	Silent	SNP	T	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:176043850T>C	uc002ujz.3	-	3	519	c.249A>G	c.(247-249)GTA>GTG	p.V83V	ATP5G3_uc002uka.3_Silent_p.V83V|ATP5G3_uc002ukb.1_Silent_p.V83V	NM_001002258	NP_001002258	P48201	AT5G3_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	83	Helical; (Potential).				ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.147)			CAGCCACTCCTACTGTTGCAG	0.443													3	67					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179399269	179399269	+	Missense_Mutation	SNP	C	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr2:179399269C>G	uc010zfg.1	-	307	94593	c.94369G>C	c.(94369-94371)GAG>CAG	p.E31457Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E25152Q|TTN_uc010zfi.1_Missense_Mutation_p.E25085Q|TTN_uc010zfj.1_Missense_Mutation_p.E24960Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32384							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGATATTCTCAATGATCTGT	0.413													3	103					0	0	0	0
POTEH	23784	broad.mit.edu	37	22	16279264	16279264	+	Missense_Mutation	SNP	T	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr22:16279264T>A	uc010gqp.2	-	4	1011	c.959A>T	c.(958-960)CAA>CTA	p.Q320L	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.Q39L|POTEH_uc002zlj.1_Missense_Mutation_p.Q155L	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	320	ANK 5.									skin(1)	1						TTGCTGTTTTTGCTCATGTAC	0.328													6	376					0	0	0	0
NDUFAF3	25915	broad.mit.edu	37	3	49060398	49060398	+	Missense_Mutation	SNP	G	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:49060398G>T	uc003cvq.2	+	4	931	c.427G>T	c.(427-429)GTG>TTG	p.V143L	DALRD3_uc003cvm.1_5'Flank|DALRD3_uc010hko.1_5'Flank|uc011bcb.1_5'Flank|MIR425_hsa-mir-425|MI0001448_5'Flank|NDUFAF3_uc003cvn.2_Missense_Mutation_p.V86L|uc003cvo.1_5'Flank|MIR191_hsa-mir-191|MI0000465_5'Flank|NDUFAF3_uc003cvp.2_Missense_Mutation_p.V86L|NDUFAF3_uc003cvr.2_Missense_Mutation_p.V86L|NDUFAF3_uc003cvs.2_Missense_Mutation_p.V86L	NM_199069	NP_951032	Q9BU61	NDUF3_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	143					mitochondrial respiratory chain complex I assembly	mitochondrial inner membrane|nucleus	protein binding				0						TGCTGTGGAAGTGCAGGACAC	0.637													4	95					0.00024832	0.000327056	1	0
CPOX	1371	broad.mit.edu	37	3	98304334	98304334	+	Missense_Mutation	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:98304334C>T	uc003dsx.2	-	5	1216	c.1123G>A	c.(1123-1125)GAC>AAC	p.D375N		NM_000097	NP_000088	P36551	HEM6_HUMAN	coproporphyrinogen oxidase precursor	375						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity				0						GTGAATGAGTCATCACAGTGC	0.517													7	234					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178947827	178947827	+	Missense_Mutation	SNP	G	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:178947827G>T	uc003fjk.2	+	19	2859	c.2702G>T	c.(2701-2703)TGT>TTT	p.C901F		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	901	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.C901F(3)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACACGTTCATGTGCTGGATAC	0.388		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			16	174					2.48551e-13	3.48616e-13	1	0
SDHAP2	727956	broad.mit.edu	37	3	195400728	195400728	+	Silent	SNP	A	G	G	rs12107841	by1000genomes	TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:195400728A>G	uc003fuw.2	+	9	1218	c.24A>G	c.(22-24)CCA>CCG	p.P8P	SDHAP2_uc011btb.1_Missense_Mutation_p.S156G|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GATTGTGCCCAGCCTGTACGC	0.587													4	38					0	0	0	0
SENP5	205564	broad.mit.edu	37	3	196612189	196612189	+	Missense_Mutation	SNP	G	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr3:196612189G>A	uc003fwz.3	+	2	386	c.137G>A	c.(136-138)AGG>AAG	p.R46K	SENP5_uc011bty.1_Missense_Mutation_p.R46K	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	46					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AAGCTGGGAAGGCCAGTTACT	0.413													4	46					0	0	0	0
USP53	54532	broad.mit.edu	37	4	120169908	120169908	+	Missense_Mutation	SNP	A	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr4:120169908A>G	uc003ics.3	+	6	1309	c.243A>G	c.(241-243)ATA>ATG	p.I81M	USP53_uc003icr.3_Missense_Mutation_p.I81M|USP53_uc003icu.3_Translation_Start_Site	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	81					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						CCCAGACGATATTTGCACAGT	0.378													4	49					0	0	0	0
RAB33B	83452	broad.mit.edu	37	4	140394046	140394046	+	Missense_Mutation	SNP	G	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr4:140394046G>C	uc003ihv.2	+	2	845	c.456G>C	c.(454-456)TTG>TTC	p.L152F		NM_031296	NP_112586	Q9H082	RB33B_HUMAN	RAB33B, member RAS oncogene family	152					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding				0	all_hematologic(180;0.162)					AATGTGACTTGAGAAGTGCCA	0.398													4	126					0	0	0	0
DCHS2	54798	broad.mit.edu	37	4	155278384	155278384	+	Missense_Mutation	SNP	G	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr4:155278384G>C	uc003inw.2	-	6	787	c.787C>G	c.(787-789)CTA>GTA	p.L263V	DCHS2_uc003inx.2_Intron	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	263	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		aagtgccttagcagaggtaaa	0													11	136					0	0	0	0
PCDHB2	56133	broad.mit.edu	37	5	140476001	140476001	+	Silent	SNP	T	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr5:140476001T>C	uc003lil.2	+	1	1765	c.1627T>C	c.(1627-1629)TTG>CTG	p.L543L	PCDHB2_uc003lim.1_Silent_p.L204L	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	543	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCCCGGCGTTGAGCAGCGA	0.706													6	89					0	0	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140734835	140734835	+	Missense_Mutation	SNP	T	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr5:140734835T>C	uc003ljq.1	+	1	68	c.68T>C	c.(67-69)CTG>CCG	p.L23P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.L23P	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	23					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGGGGTTCTGGTGGAAATC	0.637													6	73					0	0	0	0
ADAM19	8728	broad.mit.edu	37	5	156934137	156934137	+	Missense_Mutation	SNP	A	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr5:156934137A>G	uc003lwz.2	-	10	981	c.917T>C	c.(916-918)TTC>TCC	p.F306S	ADAM19_uc003lww.1_Missense_Mutation_p.F39S|ADAM19_uc011ddr.1_Missense_Mutation_p.F237S	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	306	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTGCCGTGGAAGGACATGCC	0.617													3	80					0	0	0	0
RIMS1	22999	broad.mit.edu	37	6	72968708	72968708	+	Missense_Mutation	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr6:72968708C>T	uc003pga.2	+	18	3024	c.2947C>T	c.(2947-2949)CCA>TCA	p.P983S	RIMS1_uc011dyb.1_Missense_Mutation_p.P608S|RIMS1_uc003pgc.2_Missense_Mutation_p.P609S|RIMS1_uc010kaq.2_Missense_Mutation_p.P456S|RIMS1_uc011dyc.1_Missense_Mutation_p.P457S|RIMS1_uc010kar.2_Missense_Mutation_p.P376S|RIMS1_uc011dyd.1_Missense_Mutation_p.P442S|RIMS1_uc003pgf.2_Missense_Mutation_p.P199S|RIMS1_uc003pgg.2_Missense_Mutation_p.P200S|RIMS1_uc003pgi.2_Missense_Mutation_p.P199S|RIMS1_uc003pgh.2_Missense_Mutation_p.P199S|RIMS1_uc003pgd.2_Missense_Mutation_p.P200S|RIMS1_uc003pge.2_Missense_Mutation_p.P200S|RIMS1_uc011dye.1_5'UTR|RIMS1_uc011dyf.1_5'Flank|RIMS1_uc003pgb.3_Missense_Mutation_p.P609S|RIMS1_uc010kas.1_Missense_Mutation_p.P442S	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	983					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TGAAATTCATCCAACAAGAAG	0.388													6	90					0	0	0	0
PDE1C	5137	broad.mit.edu	37	7	31862847	31862847	+	Silent	SNP	G	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:31862847G>A	uc003tcm.1	-	14	1891	c.1422C>T	c.(1420-1422)AGC>AGT	p.S474S	PDE1C_uc003tcn.1_Silent_p.S474S|PDE1C_uc003tco.1_Silent_p.S534S|PDE1C_uc003tcr.2_Silent_p.S474S|PDE1C_uc003tcs.2_Silent_p.S474S	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	474	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CATCTGACGAGCTGATGCTAT	0.438													4	54					0	0	0	0
SEMA3C	10512	broad.mit.edu	37	7	80546045	80546045	+	Missense_Mutation	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:80546045C>T	uc003uhj.2	-	2	615	c.53G>A	c.(52-54)TGT>TAT	p.C18Y	SEMA3C_uc011kgw.1_Missense_Mutation_p.C36Y|SEMA3C_uc011kgx.1_Translation_Start_Site	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	18					immune response|response to drug	membrane	receptor activity			ovary(1)	1						TCCTTTCACACAGATAGAACA	0.348													9	54					0	0	0	0
NPTX2	4885	broad.mit.edu	37	7	98254269	98254269	+	Missense_Mutation	SNP	G	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:98254269G>C	uc003upl.2	+	3	856	c.679G>C	c.(679-681)GTG>CTG	p.V227L		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	227	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			TGCGTTCAAGGTGTCCCTCCC	0.607													19	226					0	0	0	0
OR9A4	130075	broad.mit.edu	37	7	141618783	141618783	+	Silent	SNP	G	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:141618783G>A	uc003vwu.1	+	1	108	c.108G>A	c.(106-108)GTG>GTA	p.V36V		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					TCTACTTGGTGACATTAATGG	0.428													6	157					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	4494966	4494966	+	Missense_Mutation	SNP	C	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:4494966C>G	uc011kwk.1	-	2	590	c.200G>C	c.(199-201)CGC>CCC	p.R67P		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	67	Extracellular (Potential).|CUB 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TATCCTATTGCGCTCGCCCGT	0.468													4	101					0	0	0	0
PXDNL	137902	broad.mit.edu	37	8	52320759	52320759	+	Missense_Mutation	SNP	A	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:52320759A>G	uc003xqu.3	-	17	3526	c.3425T>C	c.(3424-3426)ATT>ACT	p.I1142T	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1142					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ACCCCTTTGAATGATGGTGGC	0.493													5	122					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113249436	113249436	+	Missense_Mutation	SNP	A	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:113249436A>T	uc003ynu.2	-	67	10769	c.10610T>A	c.(10609-10611)ATG>AAG	p.M3537K	CSMD3_uc003yns.2_Missense_Mutation_p.M2739K|CSMD3_uc003ynt.2_Missense_Mutation_p.M3497K|CSMD3_uc011lhx.1_Missense_Mutation_p.M3368K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3537	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAGCAGCTCCATGTTGCTATT	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	94					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113662433	113662433	+	Nonsense_Mutation	SNP	G	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:113662433G>T	uc003ynu.2	-	19	3309	c.3150C>A	c.(3148-3150)TGC>TGA	p.C1050*	CSMD3_uc003yns.2_Nonsense_Mutation_p.C322*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.C1010*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.C946*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1050	Extracellular (Potential).|Sushi 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTTTTTTTCGCATAGAAGGG	0.393										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	90					0.000602214	0.000774276	1	0
SHARPIN	81858	broad.mit.edu	37	8	145154650	145154650	+	Silent	SNP	C	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr8:145154650C>G	uc003zba.2	-	4	1099	c.615G>C	c.(613-615)CTG>CTC	p.L205L	SHARPIN_uc003zbb.2_RNA	NM_030974	NP_112236	Q9H0F6	SHRPN_HUMAN	shank-interacting protein-like 1	205	Interaction with SHANK1 (By similarity).				negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			ovary(1)	1	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTGAACACTCAGGGCCACAC	0.652													3	74					0	0	0	0
ZNF658	26149	broad.mit.edu	37	9	40774387	40774387	+	Missense_Mutation	SNP	G	C	C			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:40774387G>C	uc004abs.2	-	5	1040	c.888C>G	c.(886-888)CAC>CAG	p.H296Q	ZNF658_uc010mmm.1_Missense_Mutation_p.H296Q|ZNF658_uc010mmn.1_Missense_Mutation_p.H296Q	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TACACTCATAGTGTGTCATAG	0.403													18	167					0	0	0	0
LPPR1	54886	broad.mit.edu	37	9	104075140	104075140	+	Missense_Mutation	SNP	C	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:104075140C>A	uc004bbb.2	+	6	1096	c.697C>A	c.(697-699)CTC>ATC	p.L233I	LPPR1_uc011lvi.1_Missense_Mutation_p.L209I|LPPR1_uc004bbc.2_Missense_Mutation_p.L233I|LPPR1_uc010mtc.2_Missense_Mutation_p.L217I	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	233	Helical; (Potential).					integral to membrane	catalytic activity				0						GGTGCTGTGCCTCGGAACTCT	0.567													10	94					0.00136819	0.00169845	1	0
GRIN3A	116443	broad.mit.edu	37	9	104448991	104448991	+	Silent	SNP	T	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:104448991T>G	uc004bbp.1	-	2	1792	c.1191A>C	c.(1189-1191)GCA>GCC	p.A397A	GRIN3A_uc004bbq.1_Silent_p.A397A	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	397	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CTACAGCTCTTGCGACCAGCT	0.498													14	69					0	0	0	0
FCN1	2219	broad.mit.edu	37	9	137801651	137801651	+	Missense_Mutation	SNP	G	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr9:137801651G>T	uc004cfi.2	-	9	1066	c.974C>A	c.(973-975)CCC>CAC	p.P325H		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	325	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CGTCTAGGCGGGCCGCACCTT	0.592													8	73					0.00307968	0.00373714	1	0
SSX6	280657	broad.mit.edu	37	X	47972589	47972589	+	Silent	SNP	G	A	A			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:47972589G>A	uc004dix.1	+	5	416	c.294G>A	c.(292-294)CAG>CAA	p.Q98Q	SSX6_uc011mlv.1_Silent_p.Q98Q	NM_173357	NP_775493			SubName: Full=Putative uncharacterized protein SSX1;												0						AACGTCCTCAGATGACTTTTG	0.448													9	101					0	0	0	0
HUWE1	10075	broad.mit.edu	37	X	53571698	53571698	+	Missense_Mutation	SNP	T	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:53571698T>G	uc004dsp.2	-	72	11476	c.11074A>C	c.(11074-11076)ATT>CTT	p.I3692L	HUWE1_uc004dsn.2_Missense_Mutation_p.I2500L|HUWE1_uc004dsq.1_Missense_Mutation_p.I7L	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3692					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GATGCCACAATTACCACATTC	0.483													4	39					0	0	0	0
ZMAT1	84460	broad.mit.edu	37	X	101138797	101138797	+	Silent	SNP	A	G	G			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:101138797A>G	uc004eim.2	-	2	4587	c.1089T>C	c.(1087-1089)CAT>CAC	p.H363H	ZMAT1_uc011mrl.1_Silent_p.H534H|ZMAT1_uc004ein.2_Silent_p.H363H|ZMAT1_uc011mrm.1_Silent_p.H363H	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	363						nucleus	zinc ion binding			ovary(1)	1						GTTTCTGTTTATGACCTGCTT	0.383													4	51					0	0	0	0
SERPINA7	6906	broad.mit.edu	37	X	105280605	105280605	+	Missense_Mutation	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:105280605C>T	uc004eme.1	-	1	461	c.445G>A	c.(445-447)GAT>AAT	p.D149N	SERPINA7_uc010npd.2_Missense_Mutation_p.D149N|SERPINA7_uc010npe.1_Missense_Mutation_p.D149N	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	149					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	GTCTTGACATCATTCAAGAAC	0.428													6	95					0	0	0	0
SLC6A14	11254	broad.mit.edu	37	X	115582641	115582641	+	Missense_Mutation	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:115582641C>T	uc004eqi.2	+	8	1069	c.965C>T	c.(964-966)TCC>TTC	p.S322F		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	322	Helical; Name=6; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	ATATTTTACTCCCTTTCAGTG	0.303													5	46					0	0	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994645	140994645	+	Silent	SNP	C	T	T			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:140994645C>T	uc004fbt.2	+	4	1741	c.1455C>T	c.(1453-1455)TCC>TCT	p.S485S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	485							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGCTCCTCCTCCTCCTCCT	0.478										HNSCC(15;0.026)			7	126					0	0	0	0
MAGEA6	4105	broad.mit.edu	37	X	151870027	151870027	+	Missense_Mutation	SNP	C	G	G	rs144083108		TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrX:151870027C>G	uc004ffq.1	+	3	911	c.717C>G	c.(715-717)TTC>TTG	p.F239L	MAGEA6_uc004ffr.1_Missense_Mutation_p.F239L|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	239	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGTATCTTCGGGGATCCCA	0.537													10	124					0	0	0	0
DRGX	644168	broad.mit.edu	37	10	50574313	50574313	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr10:50574313delG	uc010qgq.1	-	6	655	c.655delC	c.(655-657)CGCfs	p.R219fs		NM_001080520	NP_001073989	A6NNA5	DRGX_HUMAN	dorsal root ganglia homeobox	219					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GAGTGCTCGCGGGCCTTCATG	0.672													---	---	---							
Unknown	0	broad.mit.edu	37	12	113492284	113492285	+	IGR	INS	-	A	A	rs34462445		TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr12:113492284_113492285insA								OAS2 (42757 upstream) : DTX1 (3377 downstream)																							CTCAATGGACCAAAAAAAAAAA	0.381													---	---	---							
Unknown	0	broad.mit.edu	37	15	22567508	22567509	+	IGR	INS	-	T	T	rs142681987	by1000genomes	TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr15:22567508_22567509insT								MIR1268 (54228 upstream) : GOLGA8DP (134776 downstream)																							TCTGCTTAGTATTTTTTTGTCT	0.371													---	---	---							
NANOS3	342977	broad.mit.edu	37	19	13986003	13986003	+	5'Flank	DEL	T	-	-	rs77913995		TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:13986003delT	uc002mxj.3	+							NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3						anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			TAAAATCCCCttttttttttt	0.269													---	---	---							
LMTK3	114783	broad.mit.edu	37	19	49014769	49014769	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr19:49014769delG	uc002pjk.2	-	2	152	c.152delC	c.(151-153)CCGfs	p.P51fs		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGGGTGGGCCGGGGACGCCAG	0.741													---	---	---							
C6orf174	387104	broad.mit.edu	37	6	127796926	127796926	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr6:127796926delG	uc003qbd.2	-	6	3110	c.2245delC	c.(2245-2247)CGCfs	p.R749fs	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	749						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TCGCTGTCGCGGGGGCTGCCG	0.692													---	---	---							
SP8	221833	broad.mit.edu	37	7	20824941	20824943	+	In_Frame_Del	DEL	GCC	-	-			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chr7:20824941_20824943delGCC	uc003suy.2	-	3	680_682	c.439_441delGGC	c.(439-441)GGCdel	p.G147del	SP8_uc003suz.2_In_Frame_Del_p.G165del	NM_198956	NP_945194	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor isoform 2	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						GCGCGGAGGAgccgccgccgccg	0.493													---	---	---							
Unknown	0	broad.mit.edu	37	Y	28780698	28780699	+	IGR	INS	-	AG	AG			TCGA-D6-6824-01A-11D-1912-08	TCGA-D6-6824-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	b658aa3f-0812-4812-8254-816d9a4d7c04	99a009ec-e31a-4a1a-bce5-d8027db9eaaa	g.chrY:28780698_28780699insAG								None (None upstream) : None (None downstream)																							CCCACTGATGACCTTCAAAGCA	0.426													---	---	---							
